text:
As The Vampire Diaries draws closer to its finale on May 13, the skeletons in Stefan's closet are finally creeping out.
In "Blood Brothers," Stefan has a flashback to almost a century and a half ago when the town of Mystic Falls went into a frantic search to round up all of the vampires. You see Stefan and Damon working together to distract the townspeople, and we have good reason to suspect Katherine's involved with the brothers fooling and betraying their family members and neighbors.
Jumping back to 2010 in another clip, Damon asks Elena about her uncle's whereabouts while tinkering with a mysterious antique. He tells Elena that Pearl "thought she was stealing his vampire compass but it was a pocket watch. That Johnathan Gilbert was a crazy scientist."
Check out the two clips from this week's episode, and tell us if you think Stefan should go back to a human blood diet like Damon.


text:
The Honker Hammer, the long barrel Buck Gardner Goose call, is slightly easier to blow and has a little deeper and raspier sound. The Honker Hammer is built for resident giant Canada geese, or for competition calling contests. The new aluminum insert, means your calls will sound clearer and crisper than ever!
Technical Information:
Technical Information:
- Call Material: Acrylic/Aluminum
- Reed: Short Reed
- Color: Blue Pearl/Polished Aluminum

subset: commoncrawl


text:
MRN Weekend Preview
By: Pete Pistone - @PPistone | MRN.com on May 2, 2013 | 1:50 P.M. EST
This weekend's NASCAR doubleheader at Talladega tops the racing calendar that also includes the K&N Pro Series West and World of Outlaws Sprint Car Series. (Photo: Getty Images)
This weekend's NASCAR doubleheader at Talladega Superspeedway tops the racing calendar that also includes the K&N Pro Series West and World of Outlaws Sprint Car Series.
The mammoth 2.66-mile Talladega Superspeedway plays host to both the Sprint Cup and Nationwide Series. For Cup teams, it marks the Talladega debut of the new Gen-6 racecar and the second restrictor-plate race of 2013 after the Daytona 500.
Defending series champion Brad Keselowski won last year's Aaron's 499 at Talladega while Matt Kenseth was victorious when the series returned in October. Sprint Cup qualifying is set for Saturday at 12:10 p.m (ET) with live coverage at MotorRacingNetwork.com.
Later that afternoon, the Nationwide Series will take center stage for the Aaron's 312. Motor Racing Network goes on the air at 2:30 p.m. On Sunday, MRN's live flag-to-flag coverage of the Aaron's 499 will begin at 12 p.m.
You can listen to all the weekend's live Motor Racing Network broadcasts on your local radio affiliate or its website. In addition, MotorRacingNetwork.com will have live streams of all Talladega coverage - and is also trackside for breaking news, results, stats, photos, audio, video and post-race analysis.
Elsewhere in the racing world, the K&N Pro Series West visits historic Stockton 99 Speedway on Saturday night. And the World of Outlaws Sprint Car Series has a two-day show at Ohio's Eldora Speedway, on Friday and Saturday nights.
Stay with MotorRacingNetwork.com for all the latest racing news 24/7!
Next MRN Broadcast
Race Center
Upcoming Cup Broadcasts
Tuesday - Jan. 23, 20187:00 PM ET
Tuesday - Jan. 30, 20187:00 PM ET


text:
June 28, 2016
Helen Mirren slams BDS during visit to Jerusalem – Rachel Shukert – Tablet Magazine 24.06.16
Mirren, in Israel to present Yitzhak Perlman with a lifetime achievement award, made clear her feelings about the BDS movement.
Read article here
And see:
Against abnormalization: BDS targets a major Lebanese-born writer – Todd Gitlin – The Tablet 23.06.16
An interview with Israeli television lands French citizen, novelist, and essayist Amin Maalouf in a bizarre and ignorant thought-crime hell.
Itzhak Perlman – the violinist-optimist June 21, 2016


text:
DreamWorks/Paramount Pictures
DreamWorks/Paramount Pictures
What he really wants to do is direct. Apparently.
You don't work with Steven Spielberg without picking up a tip or two, and Shia LaBeouf showed off his directorial skills in Kid Cudi's new music video, "Marijuana."
How'd Shia do? Check out the video after the jump...
More grainy travelogue and home video mashup than actual themed video (well, unless you count smoking up as a theme), the vid follows Cudi and his friends while lighting up and otherwise creatively partaking of the substance with friends in Amsterdam's Red Light District (never mind that he publicly declared his sobriety earlier this year).
Thanks to a couple Hitchcockian cameos, we know that Shia was among the pals rolling with the rapper, and not only shot, but directed and edited the video himself.
While it seems an unusual pairing at first, the duo has long formed a mutual admiration society, with Cudi once declaring that Shia was "killing s--t, I feel like I'm doing the Shia LaBeouf in music."
So, did Shia kill it this time?


text:
Forgot your password? Enter the email address you signed up with and we will send you a link to create a new password.
Your password reset has been submitted to the address provided.
Not specified
Medical/surgical goods, namely, portable and fixed electric lighting fixtures for use by medical/surgical personnel for medical applications; lasers for medical applications; and replacement parts for all the above
Business in Kalamazoo, MI


text:
A SOCIAL networking website exclusively for people in Sheffield is up and running.
Sheffield MAX enables individuals, businesses and organisations to create their own interactive pages, post event listings, connect with family, friends and colleagues with information, videos and images, and to blog and chat.
But doesn't Facebook do the job already?
"This is intimate, it's you and me, it's our community," says the man behind Sheffield MAX, Paul Beck.
"One thing is the level of privacy. People have shied away from Facebook because it is a global entity and they are not sure where the information goes to," he claims.
"Currently we have Sheffield Forum which is a great resource but with all due respect to it I feel Sheffield should have something a bit more sophisticated with the ability to do more than just posting texts.
"We have photographs and videos, polls and quizzes, lists of events and buying and selling."
Paul Beck is a business adviser and internet consultant and says one of the benefits will be the exchange of information and ideas in the business community. "It will promote Sheffield, its people and businesses, entertainment, education, events, sport, and research activity within the city," he says.
"Or you can just use it to order a pizza or sell a goldfish bowl like someone did the other day."
To find out how to sign up for Sheffield MAX – it's all free – go to www.sheffieldmax.co.uk, email email@example.com or phone 07877609550.


text:
From Fit to Fabric
Our Bespoke Advisors draw from decades of expertise and an extensive cloth selection to meet your exact specifications.
Trust Our Expertise
Measurements are raw materials, they are nothing without artistry. At Wingtip, the combination results in garments that are expertly fitted to your form and lifestyle.
Superior Materials
Our collection of cloths consists of the finest swatches from the most reputable names in menswear.
Hand Finished
The devil is in the details, or in this case, the functional sleeve button holes.
Step Into History
In the vault of the original Bank of Italy building, Wingtip's bespoke department occupies an unprecedented space. This provenance makes its way into every piece of custom clothing.


text:
This is the first thing i get when i get a soar throat. They taste delicious (not just this flavour, all of them are delicous!) and are made of natural ingredients.
J'aime les losanges Ricola qui sont doux mais efficaces. Ils aident à adoucir la gorge et à enlever la douleur et la sécheresse. De plus, cette saveur est délicieuse.
Just like Fishermans friends are my husband's go to, Ricola is one of mine. They work great, and help sooth. They come in a variety of different flavour, and the bags hold a lot, which is great for the price. I would definitely recommend this product
Ricola lozenges are great, they work so good when you have a cough or a sore throught, and blackcurrant is my favorite flavour
I love the Ricola brand of products. This flavor is unique and I actually liked it. I love to use their throat drops because they are loaded with so many herbs that are good for your body.
The product met my expectations. I heard a lot of great reviews about this lozenges and it really made my sore throat gone. Taste great, its a tad price but really worth it than other brands.
These reviews are the subjective opinions of ChickAdvisor members and not of ChickAdvisor Inc.


text:
After 5 amazing weeks in Australia with Britz Campervans on our epic #GoByCamper road trip we finally found ourselves waving goodbye to the land of Kangeroos and a big hello to the land of Kiwis! We flew from Cairns to Queenstown via Sydney and we're spoilt twice on the way, once by an amazing view of the Sydney CBD then again as we flew between the soaring mountains of Queenstown as we approached New Zealand and the next stage of our road trip adventure. I highly advise getting a window seat!
Even disembarking the plane is an event with grand mountains all around. Queenstown is a small airport so our bags soon appeared and we were ready to pick up our latest campervan! This time the adventure continues with Maui Motorhomes and one of their fabulous 6 berth campervans. First we needed to get from the airport to their office, made super easy by their free pick-up service. Just grab the white phone in the arrivals and dial 5 to speak to Maui. They were with us in 5 minutes and whisking us off to the Maui Centre just around the corner. Getting our new set of wheels was quick and painless, they made sure we had everything we needed for the next 3 weeks on the road travelling all the way up to Auckland. But first we had 2 nights in Queenstown to enjoy!
Exploring the Queenstown region
The great thing about having our van was we could get right to it and start exploring. Rather than just being stuck in the town centre we had a chance to be spontaneous and take a few random roads to map out the town and its grand Lake Wakatipu. The views here are just overwhelmingly spectacular from every angle and we delighted in driving along the edge of the lake and stopping numerous times to enjoy the view. It feels so quiet and serene here with nothing but the birds tweeting and the occasional boat on the water. There's plenty of little stops along most roads with car parks wide enough for campervans. We spent a couple of hours just cruising around and admiring the panoramic views.
While Lake Wakatipu is a beautiful sight its the remarkable "Remarkables" mountain range in the background that are the real draw for the eye. So called for completely obvious reasons, the vista really is remarkable and the region offers some fantastic skiing in winter with plenty of "tramping" (treks to you and me) in the warmer months. Our Top 10 holiday park was situated just a 10 minute drive from the centre of town just past the Shotover river where we witnessed some daredevil jet boat action. The boats zip up and down the river beneath the road bridge, skimming against the rocks and overhanging branches of trees, scaring the daylights out of the passengers and offering views along the gorge they wont soon forget.
Skyline Gondola
One of the best ways to get truly breathtaking views of the entire town, the mountains and the lake all in one go is by ascending to a higher vantage point with the Skyline Gondola. The trip up in a cable car gondola takes just 5 minutes and costs are rather expensive $32 per adult but you really wont get a better view than this.
Once you're at the top head over to the viewing platform where you can spend as long as you like taking photos of the spectacular scene before you. I recommend grabbing a warming hot chocolate at the cafe and sitting outside to take in some of the freshest of fresh air. There's a couple of extra activities up here too, one of which is definitely my kind of thing! The Luge covers nearly half a kilometre in length and gives you even bigger views from a high point than the viewing platform. You can get a combination gondola and luge ticket too.
While our 1 year old daughter may not have truly grasped the magnitude of what she could see up here, the photos we have of her are something quite special, well worth taking a couple of hours out of your day to enjoy the best views in town, of town!
Lunch in Queenstown
For us there really was only one area of Queenstown we wanted to have lunch, after watching boats enter the port area of Lake Wakatipu we discovered a number of cafes with tables out in the spring sunshine at "Steamer Wharf". Perfect for watching the world go by and soaking up some of the relaxed tourist atmosphere in Queenstown. The entire place seems filled with tourists and people on working holiday visas. In fact it was a couple of days before we were served by a New Zealander at any shop or cafe, such is the appeal of this town that tourists become locals. There's plenty of other eateries in the town centre as the entire place is really geared up to serve tourists with bars, restaurants and outdoor clothing stores.
Shotover Top 10 holiday park
While our holiday park wasn't right in Queenstown it was situated somewhere equally spectacular with some of the best views you're likely to ever have when looking out the window of a Maui Motorhome. The powered sites were easy to park our big beast in and the kitchen area was particularly good with a huge space to cook in and a warmly lit lounge area with an inviting fireplace and sofas too. Whenever you step outside you're surrounded by mountains again, a view that never grows old and I found myself making excuses to go outside and see it all over again. Check out qtowntop10.co.nz for more info .
Follow our New Zealand adventure
You can follow us as we travel through New Zealand with Maui Motorhomes with the hashtags #GoByCamper and #MauiMotorhomes you can also follow us on twitter at @travelwithamate and check out @MauiRentals while you're at it. We'll have plenty more blog posts, photos and videos soon!


text:
Japan PM Abe rides around Tokyo in self-driving vehicles
Japanese Prime Minister Shinzo Abe took a ride in several self-driving vehicles on the public roads in the capital on Saturday, showcasing the technology ahead of Tokyo Motor Show.
Japanese Prime Minister Shinzo Abe took a ride in several self-driving vehicles on the public roads in the capital on Saturday, showcasing the technology ahead of Tokyo Motor Show.
A piece of plastic padding which clogged up a drain is thought to have caused the breakdown of a decontamination system at Japan's crippled Fukushima nuclear plant, the operator said Sunday.
Japanese Prime Minister Shinzo Abe Thursday ordered the operator of the crippled Fukushima nuclear plant to work out a schedule for stemming radioactive water leaks as he toured the facility.
Japan's nuclear authority plans to conduct radiation contamination surveys at 600,000 points on the seabed off the crippled Fukushima nuclear plant, up from 200 places so far, a report said Saturday.
Vapour has begun rising again from a reactor at the Fukushima nuclear power plant, more than two-and-a-half years after its core melted down, the site's Japanese operator said Friday.
Japan pledged a renewed push to contain potentially hazardous leaks at Fukushima on Tuesday after the operator of the crippled plant reported spiking levels of radiation in groundwater.
New revelations of contaminated water leaking from storage tanks at the tsunami-ravaged Fukushima Dai-ichi nuclear power plant have raised alarm, coming just weeks after Japanese officials acknowledged that radioactive water ...
The Japanese government announced Tuesday that it will spend $470 million on a subterranean ice wall and other steps in a desperate bid to stop leaks of radioactive water from the crippled Fukushima nuclear plant after repeated ...
Workers will switch off one of Japan's two working reactors Monday, with the other set for shutdown later this month and no restarts in sight amid continued public hostility to nuclear power.
The operator of Japan's stricken Fukushima nuclear plant said Sunday it had found highly radioactive water dripping from a pipe used to connect two coolant tanks, patching it up using tape.


text:
VS-S15E SPY MICROPHONE is a spy in style with this spy surveillance gadget that has both video recording and digital camera functions.This spy gadget style digital video recorder brings you 1280 x 960 video.Built with the highest quality internal micro-chip components, the Digital Spy gadget allows for straight to AVI recording. It provides low illumination and HD camera,High-speed dynamic video offers instant response to dark-and-light environment.Its PC camera functions offer easy enjoyment of network life. Item:Parameters Video format:AVI Video encoding:M-JPEG Video resolution: 640*480 VGA The ratio of image:4:3 Supporting system:Windows me/2000/xp/2003/vista;Mac O/S;Linux;
We also have:
VVS-600s SPY MICROPHONE-295 pesos
IF you have any question regarding the product please contact us or send us a message here.
We GIVE Discounts to our DEALERS / INSTALLERS,
We accept payment thru Visa,Paypal,Credit card,Debit card,Online banking,E-WalletBank transfer,Direct debit,Cash and PIN payment.
For inquiries,brochures,packages please do visit our fb page at OfficialGXTECHphilippines
Tips for Online Transactions
- Avoid scams by acting locally or paying with PayPal, Bank Deposit, LBC, or Pera Padala without the item.
- Never pay with anonymous payment services
- Don't buy or sell outside of your country. Don't accept cheques
- This site is never involved in any transaction, and does not handle payments, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification"


text:
Frances Lay
- 0 years old
- Date of birth: August 21st, 2015
- Date of passing: November 21st, 2015
This memorial website was created in the memory of our loved one, Frances Lay, 0, born on August 21st, 2015 and passed away on November 21st, 2015. We will remember her forever.
Leave a Tribute:
Invite your family and friends to visit this memorial:
Subscribe to receive e-mail notifications when others contribute to this memorial.
Created in partnership with
Watson-Hunt Funeral Home
1208 Main St
Perry, GA 31069-3533
(478) 987-2423
56 views
Have a suggestion for us?


text: Attention to detail throughout in this spacious, newly renovated 4 bedroom Home with a finished basement. Enjoy home cooked meals in your custom kitchen with granite counters and stainless steel appliances. Start creating timeless memories for the coming years. Move in & start a new chapter in your life.Asking: $374,900


text:
we have a six car caravan heading from detroit to obx, nc this weekend and will be taking i-80 toward cleveland, splitting off onto i-76, then picking up i-70 toward maryland.
any suggestions for chow close to the freeway? a couple of us are huge fans of roadside bbq stands.


text:
Andy Whatley
COO/CFO, Europe
Andy is passionate about making people businesses successful and fervently believes that there is a virtuous circle between brilliant people and commercial success. Leading our Finance, Commercial and Technology teams, Andy impacts many aspects of ?What If! including: business strategy, client relationships, operations, our partner organisations, and commercials.
Before ?What If!, Andy worked with a variety of businesses from PwC, network Marketing Agencies and VC backed digital businesses. This range of experience gives Andy a broad perspective on the drivers of commercial success for both large and small business – and how to bring those into one place. He is a graduate of Durham University and qualified as a Chartered Accountant with PwC.
Outside of work, Andy is husband to Claire, Dad to Izzy and Edie, and walker of Molly (a boisterous Wheaten Terrier). He's a lover of good food, the great outdoors, and can occasionally be found on the golf course.
Back to people
The ?! moment I've felt the most Audacity:
At ?What If! the everyday standards that the team apply are incredible. Strictly speaking this isn't a "moment" so much as a permanent state. It has resulted in truly ground breaking projects and is extraordinarily inspirational.


text: I had my lazer wheel motor replaced because it was starting to leak out of the seal. It was running fine, so I'm thinking of replacing the front bearing and the seal on my old one. My question is how do I get the bearing out, do I take the whole pump apart? It's a ross pump about 11 yrs old . mb150208cccg, ccmb240, d/c239 976 d Thanks


text: Hey guys I just got an '04 Ferris DD 52". If I set the speed to full speed, then pull in on the pistols, it makes the lever come back to a slower setting. Does anyone know what causes this, or a fix for this. It's pretty annoying to have to reset your max speed after every turn. Thanks


text:
The Synthetic Biology Laboratory for the Decipherment of Genomic Codes
Asst. Prof. Roee Amit http://roee-amit.technion.ac.il/Roee-Amit
Our research combines synthetic biology with advanced imaging techniques to study problems associated with information transfer at the molecular level in biology. Our research efforts are aimed at two major fields:
1. Synthetic enhancer circuits – Deciphering the regulatory code is one of the great challenges of our time. Our approach is to "hack" this algorithm using the tools of synthetic biology. We do this by designing novel DNA regulatory sequences using characterized components, and testing if our "program" displays the predicted regulatory response. At present, this translates to constructing synthetic enhancer elements from the ground up in bacteria, and coupling them to gene circuits to generate increasingly complex modules. In the future, we intend to expand this work to embryos with a long-term goal of developing therapeutic applications.
2. Live tracking of RNA – We approach this problem by utilizing synthetic biology and advanced microscopy methods in order to simultaneously develop a specialized system of genetically encoded fluorescent probes, whose output will be detected by a dedicated imaging system. Our probes will be designed to report interactions of RNA molecules at the single molecule level, and as a result enable quantitative intra-cellular dynamical tracking of RNA and its myriad of biological function and roles.
The Laboratory of Nanostructured Molecular Assemblies
Assoc. Prof. Dganit Danino
Self-organization is a fundamental process dictating the function and properties of many proteins, peptides and lipids. Our studies aim on uncovering the structure, dynamic and characteristics of nanometric complexes which form by this self-organization. Few studies have potential application in food and medicine, as, for example, the design and formation of Cubosomes, nanometric lipid carriers loaded with drugs and nutraceuticals. Other investigations explore mechanisms of action protein nano-machines. Examples include Dynamin, which mediates endocytosis, the main pathway for internalization of nutrients into cells, and MxA, an interferoninduced protein displaying antiviral activity against virus like influenza, hepatitis and Thogoto. Using advanced cryogenic electron microscopy techniques we characterize at high-resolution and in great detail the interaction of such proteins with lipids, viruses and other cell components. This information, combined with detailed biochemical analysis will possibly reveal new therapeutic approaches against life-threatening pathogens.
The laboratory of lipids and soft matter
Asst.Prof . Maya Davidovich-Pinhas
Over the past few decades, the deleterious effects of trans and saturated fatty acids on human health have been well established. However, it is also well known that trans and saturated fatty acids, which are part of the natural fat components, play a major role in the texture and mouth sensation experienced while consuming fat products due to their unique solid-like properties. Thus, direct replacement of trans and saturated fatty acids with unsaturated fatty acids, rising a considerable technical challenge due to their low melting temperature. The research in our laboratory combines material science and food engineering concepts toward the development of new lipid systems that can mimic natural fat, with improved nutritional profile. Our goal is studying the structure and properties of fats, and developing fat mimetic systems with an aspiration to understand the structure-function relation of these systems. Oil comprises high levels of unsaturated fatty acids which provide better nutritional profile but is liquid at room temperature. Thus, various oil structuring strategies will be used comprising self-assembly and crystallization processes in order to mimic fat structure. Our research aims to find the correlation between the nanoscale molecular structure, by using imaging and scattering techniques, to the meso-scale characteristics, by using rheological, mechanical, and thermal techniques. Such knowledge can potentially open a path for development of innovative healthier food products.
The Laboratory of Molecular and Applied Biocatalysis
Assoc. Prof. Ayelet Fishman http://afish.technion.ac.il
Biocatalysis is the use of enzymes or cells to carry out defined chemical reactions under controlled conditions, in order to convert raw materials into commercially more valuable products. The high selectivity of enzymatic transformations, combined with the mild reaction conditions and the use of inexpensive reagents, represent sound advantages for biocatalysis. Our interdisciplinary research is aimed at developing novel and efficient processes for synthesizing natural food additives and drug intermediates in aqueous and nonaqueous media. In order to render the enzymes more suitable for industrial conditions, we employ a technique called Directed Evolution. This is a novel approach based on the Darwinian algorithm of mutation and selection, which allows to explore and improve enzyme functions by iteratively altering the amino acid sequence and finding the mutant with the desired properties. Projects in the lab include the synthesis of a natural fragrance compound using yeast isolates, producing enantiopure sulfoxides using monooxygenases, and searching for novel enzymatic activities in genomes derived from soil and sea water.
The Laboratory of Applied Genomics & Food Microbiology
Prof. Yechezkel Kashi
Our research team in the Faculty of Biotechnology & Food Engineering at the Technion is focused in three major research fields:
1. Environmental microbiology – genomics, pathogenesis, and evolutionary studies of V. vulnificus and V. cholera.
2. Gut microbiome – understanding the role of host's genetics on microbial composition and host microbial interactions.
3. Biodiversity and genetics of yeasts, Saccharomyces cerevisiae.
These studies combine methodologies of molecular genetics, SSR genotyping, next generation sequencing, bioinformatics and classical microbiology in culture and in animal models.
The laboratory of chemistry of foods and bioactive compounds
Asst. Prof . Uri Lesmes http://lesmesu.net.technion.ac.il/
Improving human health and prevention of diseases through rational design of food and biotechnological formulations require comprehensive understanding and control over complex chemical reactions and interactions. Our group is involved in studies of complex reactions and interactions of bioactive ingredients using advanced analytical tools and metabolomic approaches. Using unique bioreactors designed to simulate the human digestive tract we also investigate the reactions and events occurring within the digestive tract of humans, throughout the lifespan and across a range of human conditions.
Our ongoing work seeks to harness naturally formed conjugates and molecular hybrids to fabricate novel food-grade ingredients, hydrocolloids, nano-laminated emulsions, modified interfaces, retard contaminant formation and degradation of beneficial components. Through our studies we seek to understand how one can modulate digestion reactions and luminal contents, e.g. reducing lipid digestion as well as personalize nutrition to specific human conditions. Overall, our efforts focus on understanding the potential beneficial and deleterious effects on human health and well-being that originate from man-made manipulations and changes in the structure and composition of foods and other formulations.
The Laboratory of Mammalian Cell Technology
Prof. Ben-Zion Levi http://levilab.net.technion.ac.il/
Bone marrow derived hematopoietic stem cells give rise to all blood cell types among which are myeloid cells that constitute an essential arm of innate immunity. This hierarchical cell fate decisions process is orchestrated by key transcription factors. These factors govern and modulate the expression of lineage specific genes. Aberrant expression of these key regulators results in block in the differentiation process and subsequently leads to leukemias. Lineage specific expression is the hallmark of this complex differentiation process, yet the molecular mechanisms that govern this lineage restricted expression are not elucidated. Our research is focused on the molecular mechanisms that govern transcriptional regulation of genes in general and during myeloid cell differentiation in particular. We study a transcription factor termed IRF-8, which is essential for the ability of progenitor cell differentiation toward the monocyte arm of the myeloid cells. We demonstrate that epigenetics modifications are essential for this lineage specific expression. Further, we study gene regulatory network governed by IRF-8 and its role in the differentiation process, the activity of the mature cells and the suppression of leukemias. Our research will allow future drug design to manipulate the immune system and to eliminate cancer cells and invading pathogens.
The Lab of Food Physical Chemistry & Biopolymeric Delivery Systems for Health
Assoc. Prof. Yoav D. Livney http://biopolymeric-nano-carriers-4-health.net.technion.ac.il/
Proteins and polysaccharides are essential components of food and other biological systems. To improve their stability and functionality during technological processes we study the mechanisms of protection conferred to them by low-molecular weight co-solutes like salts and saccharides in aqueous systems, using advanced instrumental techniques combined with modeling and computerized atomistic simulations.
We also harness the binding of small bioactive molecules (nutraceuticals and drugs) to biopolymers, and their co-assembly, to form nanodelivery systems for promoting human health. In designing these nanodelivery systems we draw inspiration from natural delivery systems, like the casein micelle in milk, which evolved to deliver calcium and protein from mother to the baby. The nano-delivery systems we design, for the enrichment of widely consumed staple foods and beverages with nutraceuticals, confer protection to these sensitive compounds against deterioration during processing and shelf-life, without sacrificing desirable sensorial properties, and promote their bioavailability to the body.
To combat cancer we rationally design targeted nanoscopic vehicles for either oral or systemic delivery, loaded with synergistic combinations of drugs, diagnostic-aids and chemosensitizers to overcome drug resistance. These nanoscopic vehicles employ the "Trojan-horse" approach: selective uptake by cancer cells, followed by release of drugs and chemosensitizers to eradicate the cellswhile labeling their location for complementary treatments.
The Laboratory for Cancer Drug Delivery & Tissue Engineering
Prof. Marcelle Machluf URL: http://drugcelltherapy.net.technion.ac.il
The research in our laboratory combines material engineering and life sciences towards the development of new delivery platform of cells, proteins and gene for cancer therapy and tissue engineering.
Gene Therapy: Developing non viral vectors for gene delivery such as ultrasound, nano- polymeric particles made of Chitosan and polylactic co-glycolic acid, alginate.
Drug Delivery Systems: Developing nano and micro size particles for the delivery of anti-inflammatory and anti-cancer drugs particularly anti-angiogenic drugs.
Cell Bioencapsulation: Developing cell encapsulation procedure for cell based therapy. These systems are used to immune protect cells that are genetically modified, primary cells and stem cells.
Tissue Engineering: Engineering organ in the laboratory particularly heart, blood vessels and nerve. Developing scaffolds which are based on 3D accellular collagen matrices isolated from large animals. Developing bioreactors for the long term culturing of tissue engineered organs.
HIV/AIDS: Developing complex proteo-polymeric drug delivery systems for targeting and killing HIV infected cells and for the entrapment of free roaming virions in the blood and lymph fluids.
The laboratory of Molecular Nutrition
Asst. Prof . Esther Meyron Holtz
Iron is an essential nutrient for most organisms. Iron deficiency leads to anemia with its many pathologic implications and iron overload leads to complications such as liver cirrhosis, liver cancer and diabetes. Therefore iron uptake and distribution needs to be carefully regulated and this regulation is the focus of our research. The two Iron Regulatory Proteins are responsible for the regulation of cellular iron uptake. In a mouse model lacking the Iron Regulatory Protein 2 iron distribution throughout the body and especially the brain is miss-regulated which leads to anemia and a neurodegenerative disorder that resembles Parkinson disease. We study the role of the iron storage protein ferritin in the pathophysiology of this neuro-degeneration.
Systemic iron distribution is also depending on macrophages, a cell type that plays many roles including in the immune system. These cells eliminate senescent red blood cells and recycle their iron for new hemoglobin synthesis. Characterization of the macrophage response to red blood cell ingestion may lead to strategies to strengthen the immune system in the many disorders where red blood cell half-life is shortened.
The laboratory of Antimicrobial Peptides Investigations (LAPI)
Prof. Amram Mor
The development of new, safe/efficient and economically viable tools for fighting multidrug resistant (MDR) pathogens is of prevalent need. The Mor group has recently reported a novel design of chemical mimics that is founded on lipopeptide-like oligomeric arrangements of acylated cationic building blocks. Initial characterization of lysine-based representatives (termed oligo-acyl-lysyls, OAKs) led to several intriguing findings: (i) The OAK platform can generate small molecules that selectively exert antimicrobial (and anticancer) properties using distinct sequence-specific mechanisms; (ii) Some OAKs can potentiate certain drugs (eg, antibiotics), restoring sensitivity of MDR cells, in some cases) ; (iii) OAKs interaction with phospholipids induce cochleates formation, which can be exploited for efficient co-encapsulation of the synergistic drugs and for co-delivery in systemic treatment of infection. Collectively, these findings argue for the potential of OAKs in providing a comprehensive system for fighting MDR bacteria.
The group's current efforts attempt to extend these studies and exploit accumulated knowledge for further developing the OAK approach while focusing on particularly short antibacterial sequences. Thus, design principles that emerged from previous studies are used to inspire the design of new improved derivatives towards defining essential chemo-physical properties that impact extra- and intra-cellular targets, in presence and absence of antibiotics, in-vitro and in-vivo. Knowledge gained over the course of this project will aid in the rational design of optimal antimicrobial agents for mono- and/or combination-therapy.
The Laboratory of Biomaterials
Asst. Prof. Boaz Mizrahi http://boazmizrahi.net.technion.ac.il
Biomaterials science is the next frontier in biotechnology and in medical therapeutics. Innovations in material design have created interventions and composite devices previously unimaginable with materials whose structure and function evolve with time. Our lab develops a research program in the area of dynamic, functional bio-inspired materials. Research involves the synthesis and characterization of functional polymers with medical applications. This is naturally proceeding to an effort to the development of novel biotechnological innovations based on these materials. We also attempt to gain a critical level of understanding of structure-activity relationship and tissue-biomaterial interactions in the general context of materials science. Current research includes the synthesis of injectable and of stimuli responsive materials, delivery of nutritious for treating gastro and mucosal disorders, self-assembly of polymeric systems and nano-scale particulate systems.
The Laboratory of Functional Nanomaterials, Biosensors, and Sensors
Assoc. Prof. Ester Segal http://segallab.technion.ac.il
Our multidisciplinary research group combines materials science and engineering, biotechnology, and applied physics and chemistry toward the development of novel functional nanomaterials. We design, synthesize and study new nanomaterials for various advanced technologies, including intelligent packaging, sensors, and biosensors. Current and future needs for food quality assurance, food safety and bio-security strongly require new and improved diagnostics to screen for chemicals, toxins and bacterial pathogens in complex food matrices. Introduction of these diagnostic functionalities into food packaging represents the emerging concept of intelligent packaging. Thus, our aim is to develop rapid, accurate, cost effective, reliable, non-invasive and non-destructive sensing platforms that could in future power intelligent forms of food packaging. These materials will be designed to perform different tasks, including detecting, sensing, biosensing, and tagging. We study the interrelation between structure, properties and functionality of our nanomaterials. The potential of these technologies is far reaching, and is expected to have an impact on numerous disciplines including, packaging science, biotechnology, polymer science, nanotechnology, biodefence and sensor science.
The laboratory for Novel food and bioprocessing
Asst. Prof. Avi Shpigelman
There is a growing awareness that a healthy diet improves well-being, extends life expectancy and reduces the risk of certain illnesses (like the metabolic syndrome, cancer and neurodegenerative diseases). It is clear that processing and storage (both industrial, commercial and domestic) can alter the concentration, structure, bio-accessibility, bioavailability and the eventual biological effect of many of the health promoting food compounds. The goal of our research group is to maximize health-promoting attributes of foods by a more rational utilization of novel and traditional food processing and storage techniques. This is achieved by in-depth studies (combining experimental and modeling approaches) of the effects of various processing techniques on food bio-actives, macromolecules (polysaccharides, proteins, and enzymes), micro and nano-structures, and how interactions between them upon processing affect the bioactive compounds. The basic nature of our studies towards a better understanding of the effects of processing and storage also allows us to seek opportunities in the development of foods from novel sources and the development of processing that will allow the age of personalized and group based nutrition.
The Protein and Enzyme Engineering Laboratory
Prof. Yuval Shoham
The natural degradation of plant cell wall matter in Nature is a key element in the Carbon cycle on Earth. Moreover, lignocellulose is considered the most viable option as a renewable energy source that contributes zero net emission of carbon dioxide. The main difficulty in using cellulose as an energy source is its crystalline nature which is highly resistance to hydrolysis. Our laboratory is trying to reveal and understand how enzymes and microbial systems breakdown the plant cell wall material in Nature, and how can we utilize these systems for biotechnological applications. For example, developing an economic process for generating biofuel from cellulose. Our main research systems include the cellulosome complex from C. thermocellum and the hemicellulolytic system of G. stearothermophilus. We utilize an integrated research approach combining biochemistry, X-ray crystallography, genetic engineering, gene-regulation, microbial physiology and fermentation technology. Studies from our laboratory provided an industrial process for the bio-bleaching of paper pulp, and revealed new crystal structures and new catalytic mechanisms of several glycoside hydrolases.
The Laboratory of Molecular Biology of Pathogens
Assoc.Prof. Sima Yaron
Extensive use of antimicrobials for medical reasons and in farms and households has led to the rapid development of resistance in disease-causing microorganisms. Our research efforts are aimed at two major fields: (i) to investigate mechanisms of resistance to antibacterial agents and (ii) to design and develop new antimicrobials to combat resistant pathogens. We particularly study food borne pathogens associated with highly protected states of existence. The research has made advances in each of the following points, and thus has important implications for both combating infections and for food safety.
Microbial resistance: characterization of emerging multiple antibiotic resistant food borne pathogens, understanding the mechanisms of cross resistance to antibiotics, food preservatives and sanitizing agents, and development of new antimicrobial agents to combat resistant pathogens.
Microbial biofilms: biofilm development on different surfaces, resistance of biofilm cells to antimicrobials, and development of new technologies for removal of bacterial biofilms.
Food safety: molecular study of the behavior of food-borne pathogens in water and fresh ready to eat foods.
The laboratory of Nano-Bio-hybrid Systems for nanotechnological applications
Dr. Omer Yehezkeli http://yehezkeli.net.technion.ac.il/
The research in our group is multidisciplinary, shifting from biochemistry and bioengineering to bioelectrochemistry and nanotechnology. Generally, we use the unique properties of nanomaterials (electrical, optical) with enzymes to gain synergetic effect in catalysis and sensing. Our goal is to construct novel biohybrid systems with unnatural triggers for enzyme activation. To gain that, we use electrodes or nanomaterials which allow directed or mediated electron transfer into the enzymes active sites. As a multi-disciplinary lab, our tools vary from electrochemical setups and glove box to electrophoresis and separation columns. Major research direction aims to form biohybrids which activates nitrogenase by light stimuli. Furthermore, the nitrogenase will be further coupled to electrodes for the construction of biofuel or photobioelectrochemical cells.
The work in the lab is focused on several topics:
- Enzymes extraction, purification and testing
- NPs and NRs synthesis
- Biohybrid assembly for variety of applications
- Electrode modification
- Enzyme based amperometric biosensors
- Bioelectrochemistry applications


text:
Katie Yip
Coming from an athletic background, Katie is driven to find a potent balance between health and performance. She began her training with Chris Robinson at S6 Fitness in San Diego, and then completed her apprenticeship under Brooke Siler and Cary Regan at re:AB Pilates in NYC. Katie's passion, ambition, and everyday discipline to her training and education have helped her cultivate an understanding of what it means to have strength with flexibility and control. She combines her science-based education and intuition to transform the way her client's move, look, and perform.
Katie is a graduate of the University of California, San Diego where she earned her B.S. in Physiology & Neuroscience. She is currently a Master's Candidate in Kinesiology and Exercise Physiology at Columbia University. She continues to study the Pilates method and is grateful for the knowledge her teachers' Chris Robinson, Brooke Siler, Cary Regan, Victoria Torrie-Capan, and Kathi Ross-Nash have shared with her.
My training philosophy focuses on establishing and consistently improving fundamental fitness skills. Before beginning any skill intensive sports or activities, athletes, weekend-warriors, and anyone in pursuit of optimal health should understand how to move efficiently through basic movement patterns. This requires strength, joint stability, full physiological range of motion, motor control, balance, endurance, and importantly, movement without pain.
In an attempt to counteract the ubiquity of the modern day sedentary lifestyle, we engage in highly technical activities without a fundamental foundation of basic fitness. Poor fitness cannot be solved with aggressive physical training, and building a set of intricate skills on dysfunction compromises performance and increases risk of injury. I have found that Pilates, when taught correctly, is one of the best platforms to create a solid foundation with which athletics and other modalities of exercise can be built upon.


text:
Download ALUCID PEIG apk 2.51.1 free for Android smartphone
Posted by ANECT a.s. in Personalization | Oct. 6, 2014 | 0 Comments
Apk file size: 4.8 MB
PEIG (Personal Electronic Identity Guardian) is the client part of the authentication technology ADUCID.
The underlying technology is based on the revolutionary DII concept (Distributed Identity Infrastructure) and delivers a unique combination of user-convenience, highest level of security and efficiency in one innovative and highly robust solution. Other than authentication the main features of the technology are procurement of user's approval for a number of different types of server operations (i.e. money transfers, changing authorization settings and more) along with protection against misuse by unauthorized personnel.
IMPORTANT NOTICE! PEIG can only be used with providers/services supporting the authentication with ADUCID technology.
Whats new
- Minor bug fixes
ANECT a.s. part of our Personalization and have average installs from 100 to 500. Last Update Oct. 6, 2014. Google play rating is 92.0. Current verison is 2.51.1. Actual size 4.8 MB.


text:
Bow Down (Barone Crime Family #5) by B.B. Hamel
I want to take on the world, but that arrogant bastard just wants to take me.
I'm no mob princess. But I should've been.
When my father, the head of the Barone Crime Family, refused to let me join his organization, I left and started my own gang. Now we're at war, and I'm trying destroy everyone in my way.
But I need help from someone powerful if I'm going to win.
Young, tall, and handsome, Wyatt Carter is no normal politician. He's a well-known former bad boy turned State Attorney General.
His perfectly tailored suits cover the tattoos that snake up his sexy muscular arms. I hate that I want to let those arms pin me up against a wall.
It's supposed to be just business between us, except Wyatt wants more than I'm willing to give.
I have to let my guard down if he's going to help me. But Wyatt doesn't know where the line is — and even if he did, he'd cross it.
I'll bow down to him, but first he has to lay the world at my feet.
Download Links
(Note: Use Userscloud to download in Mobi and PDF Format)


text:
Ultra-exclusive and private west coast villa, ideal for larger families or groups with additional villa options, oceanfront with direct access to 2 beaches, close to west coast attractions, Sandy Lane and Royal Westmoreland golf courses, home theatre.
Greensleeves is enviably situated on the 'platinum' west coast of Barbados, approx. 35 minutes from the airport and less than 10- drive from the historic town of Holetown where you will find bars, restaurants and designer shopping at Lime Grove mall.
Enquire nowGreensleeves