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Dec 09 2007
EcoView: Six Metres and Rising: a play in one act
Six Metres and Rising
A play in one act
(Generously submitted to Currents by friend and creative genius Mr. Earnest Canuck)
DAVID SUZUKI, an environmentalist.
STEPHEN HARPER, a politician.
WEN JIABAO, another politician.
KING CANUTE, another.
GLOBAL CLIMATE, an entity, played by a hot woman.
KYOTO, a dog.
CURTAIN. A Vancouver beach in winter. DAVID SUZUKI, wearing only a thong, performs labourious Tai Chi exercises, puffing out his cheeks. Enter STEPHEN HARPER, carrying a laptop.
HARPER: What kind of activity are you carrying out there, David Suzuki?
SUZUKI: Capping, pant, my emissions of greenhouse, pant, gasses, Prime, pant, Minister.
HARPER: Really? And this capping, is it the manner of thing done by cool people, statistically?
SUZUKI (angrily): Yes…!
HARPER (thoughtfully): I should have capped my emissions when I was a schoolboy. Statistically, I might have reduced the percentile of days spent with my underwear around my neck. Statistically. (Sits, opens laptop.) Hey, Suzuki…? What's 450 million years old and two miles thick?
SUZUKI: Your government's heartless indifference, maybe, to future generations? Ha, ha!
HARPER: Ha, ha! Ha. Um, no, though. Let me refer to the punchline here. It was the ice sheet in Ordovician times, when atmospheric carbon dioxide was ten times higher than –
(Enter GLOBAL CLIMATE, pursued by KING CANUTE. WEN JIABAO reluctantly trails in after them.)
GLOBAL CLIMATE: Micronations! Crop failure! SUVs! Sustainable! Carbon trading! Sustainability! Fossil fuels! Flossing!
KING CANUTE (imploringly): Why were you so hot for me, Global Climate, and now you're so cold? Please! Baby! Can't we go through the highs and lows together? Don't go changing, just to please me –
WEN JIABAO: All right, King Canute, that's enough. You'll never lower her tube top's see level. It's futile! Now get the hell out of here.
CANUTE: I'll turn her back someday. You'll see. (Slinks offstage.)
CLIMATE (sadly): King Canute consensus oilsands inconvenient truthiness? (Suddenly enraged) Mean temperature! Ice calves! Sequester! Monbiot! Monbiot!
SUZUKI: So, Chinese Premier Wen Jiabao. How are you?
JIABAO: Harper, Suzuki, hello. Frankly, I'm a little tired of dealing with this Global Climate bi —
HARPER: Bit of a policy challenge, with a range of costs and opportunities, you're saying, Wen? I feel you. That is, I empathize with you. I'm feeling you.
JIABAO: I was saying, she's not my problem. Also, she's a skank.
SUZUKI: Whoa!
HARPER: Easy!
CLIMATE: Protocol! Sweet light crude! Protocol!
JIABAO: Whatever. She's quite aware what she's going through. You all stay away from my house, all right? (Exit. He shouts from offstage.) Climate changes! It's what she does!
HARPER: So. Um. Ms. Climate. Would you care for a light massage? Several studies have shown it might be medicinally beneficial. Within a margin of error. Statistically.
CLIMATE: Recycling incentive biosphere solar panel?
SUZUKI: Damn you, Harper! Just because this country has one per cent of the world's weather, doesn't mean you can fiddle with Global Climate, you, you… pollutant…
HARPER: David, I would ask you to reduce your face-punching anger by a few degrees, now. Over the next predictive time period, I mean… voluntarily…
SUZUKI: Despoiler! Climate flirter!
(HARPER and SUZUKI begin to wrestle and stagger offstage, pursued by the agitated CLIMATE.)
CLIMATE: Community gardens organic bicycle. Healing spiritual dialogue circle! Dialogue! Deniers! Exxon! Monbiot!
(Exit. Enter KYOTO.)
KYOTO: As we have seen tonight, friends, climate is a thing that affects us all. In these troubled times, we can no longer deny that each of us has some emissions. Globular warmening is no longer just a recipe, but a scientishly-acknowledged truism. Our duty to the planet and to future generations is clear: we must fossilize our remaining fuel resources. And wherever sea-level communities are threatened by changing climaxes, kibble must be provided, friends, as much kibble as the developed world can spare, lest overheated dogs lead us straight into environmental catastrophe. I may be just a small dog in a big atmosphere, my fellow citizens, but believe me: I was named for a treaty, and I know.


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Now that you have stopped drinking, your main problem is not to start again. Here are a few practical tips, based on the experience of others, that should help make this easier for you.
- Eat as much as you can. You will feel less likely to want a drink on a full stomach.
- If you do get a craving for a drink, this may simply be due to the body's demand for liquid, which is often very strong. So drink plenty — provided it's not alcoholic. Fruit juices with glucose, tea or coffee with plenty of sugar will best satisfy your body's need for plenty of liquid.
- Alcohol destroyed your limited supply of Vitamin B. Take plenty of vitamin tablets, especially those containing Vitamin B compound. They can be obtained without prescription, are not habit-forming and are quite harmless.
- A feeling of depression can be the result of being physically out of sorts. Keep your system regular.
- Never sit gazing into space with your mind a complete blank. Do something, anything positive. (a) Go for a walk. (b) Take a bath. (c) Have a shave. (d) Do a bit of gardening. (e) Clean your shoes.
(f) Make a phone call, etc. etc. Any of these will break the moody period.
- The phone is your surest link with AA help. Use it at any time.The person you contact may need your call as much as you do. So never hesitate to ring.
- Have a plan for your day. Don't just muddle through. You may not be able to carry it out but do your best.
- Easy does it. Alcoholics tend to try and do too much too quickly.
- First things first. Get your priorities sorted out, remembering always that sobriety takes precedence over everything else.
- Losing your temper is a luxury you can't afford. Remember it's even possible the other person could be right, so be tolerant and avoid emotional disturbance.
- There is no problem which a drink will not make bigger, so keep all yours down to their true size by staying sober.
- In times of difficulty when you can't get the help, the Serenity Prayer said to your God as you understand Him will bring you sufficient confidence to cope. He is always available.
Taken From "Now That You've Stopped", approved Alcoholics Anonymous literature.

subset: commoncrawl


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New Delhi: When Indian Army displayed its surgical capabilities by penetrating into Myanmar last year and killing militants, people were sceptical if such a strike could be carried out against Pakistan. After all, Myanmar is a friendly territory.
However, in the early morning hours of Thursday, 29th September 2016, the Indian Army put to rest all doubts by conducting a surgical strike at the LoC.
Amidst all this excitement and hysteria, have you ever thought what exactly a surgical strike is and how it is executed?
Let us understand:
• Experts describe surgical strike as 'a calculated manoeuvre to ensure you deliver maximum damage which gives a big surprise to your adversary'.
• A surgical strike requires intense preparation by the side planning such a strike. There is the risk of an all out war as the other country may take it as an 'act of war'.
• There has to be tremendous co-ordination among the government, intelligence agencies and the security forces for the strike to be successful.
• Such strikes are carried out by teams of specially trained commandos, also called Special Forces. These are generally executed in early morning hours as an 'element of surprise'.
• Special Forces are informed well in advance so that they could prepare accordingly for it.
• These strikes are generally quick and effective. Also, additional commandos are kept on standby for any eventuality.
• Once the operation is over, the side that has carried out the strike has to inform the other country about it.
Hence, a surgical strike is not something that can be carried out at the drop of a hat and requires meticulous preparations. But now that the Indian Army has carried out an attack like this, Pakistan has been warned that no terror attack in future will be tolerated.


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Feb 28 2006
|Printable version | Email to a friend
|Google to Step Up Efforts
A piece that appeared in the WSJ today (sub. req'd) cites Google CFO George Reyes' remark that Google's growth "is slowing due to the 'law of large numbers' and it will need to find new ways to boost revenue." As one might expect, the stock took another hit.
I think this means several obvious things for Google:
|Local Media Blog
|posted by Greg Sterling at 11:44 | comments [1] | trackbacks [0]


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Quick Details
- Place of Origin: China (Mainland)
- Brand Name: TOPWILL
- Model Number: TP7000 underwater fishing camera
- Type: underwater fishing camera
- Special Features: Waterproof / Weatherproof
- Waterproof: IP68
- Screen monitor Size: 7'' TFT Color LCD Monitor
- Monitor Depth: 15m
- Camera Angle: 92 degree
- Charger input: AC110V-240V
- High Definition: 720P
- Packaging material: Aluminum case
- Camera lights: 6 LEDs lights
Packaging & Delivery
|Packaging Details
|Carton Box
underwater fishing camera
|Delivery Time
|within 3-7days underwater fishing camera
- 7 inch TFT color monitor with sun-visor for bright environment outside
- Color CCD and of the camera, much more clear image than 420TV lines cameraHD 600 TV lines
- Waterproof, and durable material on the camera bodyfish model design
- Cold-resistant, waterproof and pull-resistant cables
- The : available camera extension cable length15m
- 6 high-power white lights for camera light source
- The continuous using time of the battery is up to 7 hours
Packing list:
(1) 1x Luxury aluminum case
(2) 1x 7 inch LCD monitor
(3) 1x Fish shape Camera
(4) 1x 15M cable
(5) 1x Aluminum battery
(6) 1x Battry charger
Our company is committed to the development of this field for many years, with advanced technology and talents. To provide customers with the most satisfactory product quality and thoughtful service. We hope to develop together with you hand in hand. All customers both at home and abroad are warmly welcome to visit our company, your satisfaction.
Our Service:
1. Your inquiry related to our products or prices will be replied in 24hrs.
2. Well-trained and experienced staffs to answer all your enquires in fluent English.
3. We can design and print packing box according to your requirements.
4. We can put your logo & model No. & series No. on the products and packing Box.
Based on the customer's demands to choose the most economical shipping terms Suggest, For sample order ship by Express, for mass order shipping by Air Cargo or By Sea We have strong cooperation with DHL,UPS,TNT,FEDEX,EMS.


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April 01, 2008
– Comments (0)
So, UBS writes down $19 billion worth of junk. Then, it announces it will be raising $15 billion in capital -- my guess via high-payout convertible debt of some kind, because, let's face it, who's gonna give them a pile of money like that without getting paid well, as well as being able to capture a piece of any equity-value increase.
In other words, current equity holders are likely to get a dilution firehose again. (Singapore's $11.5 billion rescue gave that outfit a 9% payout plus nearly 9% equity, IIRC).
But the stock's going up anyway? Welcome to Bizarro world.
View More


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Why we're just not ready to see those Bebo photos resurrected!
Bebo was pretty much every twenty-something's first experience of social networking (unless you were of the MySpace generation) and by God, did we make the most of it.
Whether it was going all Regina George and re-arranging our Top 16 friends on a whim, frantically checking to see if you had any Luvs left for the day, or spending hours thinking of hilarious in-jokes and poignant quotes to fill up your homepage, there was never a dull moment on Bebo.
The company was sold to AOL in 2008 for $850 million, but after it slowly faded into oblivion with the growth of Facebook, it was eventually shut down a few years ago. In a pretty impressive turn of events, Bebo's founder Michael Birch bought his company back for just $1 million last year and began the process of building the website into something newer and better.
Earlier this week the company announced their re-launch as a social network app for "people who don't take life too seriously."
And to be honest, it's pretty cool. It's got interactive hashtags, an amazing messaging service and some other epic features.
That's all well and good, except for the other little nugget of information that was revealed alongside that announcement. From January 31st, all photos uploaded to Bebo in its previous lifetime will be uploaded online.
Turns out things you put on the internet really do last forever. We sense some seriously embarrassing revelations coming next February…
Even though we knew that any photo we uploaded to Bebo could potentially have been seen by anyone at the time, there was a certain sense of relief when the site eventually shut down. All of those non-filtered pieces of evidence of our awkward teenage years, that extremely regretful night in Coppers or that two-month period where we decided to take up smoking at 15 to be super-cool… it's all going to be back online for the world to see.
At the very minimum we can all expect a hefty amount of cringing, some swift deleting and a LOT of slagging. But I reckon this Bebo resurrection could also lead to a few seriously awkward moments for a lot of people.
Whether it's your boss accidentally coming across those photos of you dressed like a Playboy bunny for Halloween 2006, or your current boyfriend asking why you never told him you scored his best friend years before you two started going out, once the photos go back online there's no stopping the tsunami of embarrassment from hitting you smack in the face.
So, thanks Bebo for offering us that chance to look back fondly at nostalgically at the past, but we'd rather not. Really. If you could just "accidentally" erase all of our pictures before January 31st, that'd be great, thanks…


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Why Choose RiseUpMD Downtown San Diego?
- 100% Online
- Only $39 / full year recommendation (not billed unless approved by the doctor)
- No appointment needed, Approved in 5-10mins.
- HIPAA-Compliant & Secure (your evaluation is confidential and all information is kept between you and the doctor only)
RiseUpMD.com Downtown San Diego is a leading online healthcare service that specializes in connecting patients in California with a licensed doctor over live video (Telehealth) to enable them to get their medical cannabis recommendation in minutes from the comfort of home.
Our doctors are passionate and knowledgeable about the benefits of medical marijuana and have helped thousands of patients become fully legal in accordance with California state law.
We founded RiseUpMD.com Downtown San Diego in 2016 with the belief that medical cannabis has the potential to provide relief to millions of people in California, yet the current cannabis industry has not given people a safe or reliable way to do so. Medical marijuana doctor's offices and cannabis clinics are often located in unsafe neighborhoods, have long wait times, and some even fail to follow California medical cannabis laws, putting their patients at risk.
The doctors and staff at RiseUpMD.com Downtown San Diego are unified by a single goal of improving the cannabis industry by providing patients with safe, convenient, and fully legal way to talk a doctor about getting a medical marijuana recommendation in California from their phone, computer, or tablet.
Our platform is HIPAA-compliant and ensures that your personal information is never shared with anyone but the doctor who evaluated you. Patients are only billed if approved by our doctor, so it's 100% risk-free.
Once approved, your recommendation will be available for immediate use (by printing it out) and a physical recommendation and card is mailed the same day.
Areas Serviced:
RiseUpMD.com Downtown San Diego is entirely online and therefore covers patients anywhere in the state of California.
Areas covered include North San Diego, South San Diego, Downtown San Diego, Orange County, and more!
Service Locations:
Patients with a computer and internet access across Downtown San Diego and all of Southern California can safely and compliantly access RiseUpMD.com's medical doctors with only a few clicks. RiseUpMD.com proudly serves patients throughout the Downtown San Diego, Golden Hill, South Park, BurlingGame, Middletown, Hillcrest, Mission Hills, University Heights, North Park, Old Town, Loma Portal, Liberty Station, La Playa, Ocean Beach, Point Loma, Coronado, National City, Mountain View and Encanto areas.
Location Information:
Also known as Center City, Downtown San Diego is the heart of San Diego proper, one of the largest cities in the country. It houses numerous cultural and historical draws that attract tourists from across the state. Petco Park, home of the MLB's Padres, lies within its borders and its Seaport Village hosts some boutique shops and eateries along the San Diego Pay. Famous Balboa Park is home to the San Diego Zoo, the San Diego Natural History Museum, the Fleet Science Center, the Old Globe and the San Diego Museum of Art, as well as the Japanese Friendship Garden and Botanical Building. The San Diego Civic Theatre hosts traveling plays and musical acts from across the country, and the San Diego Convention Center is home to the annual San Diego Comic-Con. Patients in Downtown San Diego and beyond are welcome on RiseUpMD.com's private and compassionate telemedicine server.
Please confirm your email before writing a review.
Took me about 10 minutes to get it done. After filling up the application I got a call from the "doc" just to verify (call lasted < 2 minutes). I didn't have to go anywhere, did it all straight from home in my boxers. I seriously couldn't believe it was that easy. HIGHLY RECOMMEND this place.
I was worried about going through a bunch of paperwork interviews driving everywhere but came across this wonderful service and it was the best experience thus far so friendly highly recommend .
Monica was more than helpful and sweet. Great hospitality, great staff. Top notch.
Minus the technical difficulties due to the dinosaur of a computer I have, getting my recommendation from RiseUpMD was one of the easiest process' I've gone through. The staff that I spoke with were so kind and understanding. They definitely made me feel comfortable!
Best experience ever.
I'm a creature of habit so I prefer to go back to places I've been to in the past, but it just so happens the the doctor I saw in the past is located in San Francisco. Decided to try RiseUpMD out mostly because I appreciated how easy and intuitive their website was. In less than 10 mins, I signed up, spoke with the doctor, and was issued my temporary card via email (hard copies come in the mail). Doctor visit done right. Thank you!
Didn't wait to long to talk to Doctor and got recommended in just a few minutes definitely worth it, especially if your like me and don't have time to physically go into a doctors office!
Was on phone with the doctor for about two minutes and answered all my questions. Highly Recommended for Insomniacs
Dr. Ross was genuinely interested in my medical condition(s). Our discussion lasted much longer than 10 minutes and he offered many suggestions, not all cannibas-related. Excellent listener and problem-solver. A+
1 person thought this review was helpful
They helped me out quickly and easily. As an insomniac, the last thing i wanted to deal with was a complicated process. But this went quickly and well. Definitely recommended.
NOTICE TO CONSUMERS: The Compassionate Use Act of 1996 ensures that seriously ill Californians have the right to obtain and use cannabis for medical purposes where medical use is deemed appropriate and has been recommended by a physician who has determined that the person's health would benefit from the use of medical cannabis. Recommendations must come from an attending physician as defined in Section 11362.7 of the Health and Safety Code. Cannabis is a Schedule I drug according to the federal Controlled Substances Act. Activity related to cannabis use is subject to federal prosecution, regardless of the protections provided by state law.


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Client profile:
Sinister Muse Records, an independent record label based in Chicago, Illinois whose stated goal is "to create an atmosphere of mutual respect between the artist and the record company."
The Muse
Some early logo concepts attempted to incorporate your typical Chicago skylines and what-not, but those ideas were discarded PDQ in favor of a character-driven motif – perhaps we could play off the 'sinister' and 'muse' theme of the label's name. After a few rounds of sketches, our designers came up with the featured figure that, despite the implied detail, is technically a fairly simple treatment using flat colors (as opposed to blends and gradients.) While certainly a little 'risque' for a traditional MOR brand, the sultry figure seemed perfect for a record company dealing with non-mainstream genres like the punk bands featured on the label. Here she is in all her glory:
The only point of contention through the project was the figure's tattoo – the 'dragon' version featured here was discarded for a 'spider web' for the finalized version. The color selection was designed to be almost 'halloweenish' and fits the 'sinister' theme as originally tasked. Designing a logo around a character usually requires a designer who is fairly savvy at illustration, as well as knowledgeable at incorporating typography into the artwork to make a complete mark. Such logos have certain advantages, as the central character can be used in various situations and environments, lending itself to a variety of marketing possibilities.
The punk scene
Oh yeah, almost forgot. Sinister Muse Records is the recording label for alternative punk bands Random 55 and Dead Town Revival and The Logo Factory designed their logos too (above.)
Sinister Muse
Type Of Project:
Logo design
Project Description:
Logo for Chicago-based independent record label. For this project, we ran with the label's name – Sinister Muse – and created a sexy, and quite sinister, muse..
Type Of Logo:
Graphic (linear.)
See types of logos for details.
Related & Similar Design Projects
© Copyright
All company logos and related artwork presented in our galleries are not for sale or license. Unless specifically noted, ALL logos & artwork are proprietary, subject to copyright/trademark and used here as logo design examples by permission from IP holder. See here for more on site copyright.


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Clinic Roundup
Thursday, May 12, 2011
NanoBio Corp., of Ann Arbor, Mich., began two Phase III trials of NB-001 for cold sores, as part of its 2009 licensing agreement with GlaxoSmithKline Consumer Healthcare, a division of GlaxoSmithKline plc, of London. The trials will enroll a total of 1,700 subjects at 72 clinical sites, and are expected to conclude in 2012.
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Tel: +1-215-278-8411
Outside of the US
Tel. +44-20-3811-5317
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Outside of the US
Tel. +44-20-3811-5317
Note: our contact information has changed
Customer Care: http://support.clarivate.com
© 2018 Clarivate Analytics.
Reproduction, reposting content is strictly prohibited.
Reproduction, reposting content is strictly prohibited.


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Take 2 Calcium & Call Me In The Morning
I like to read some of the different postings on various discussion boards regarding agriculture. One of my favorite sites recently referred to an article that I found quite interesting. Here is the link:
This article discusses the role that calcium, when bound to a protein, has by prompting plants to make salicylic acid when it is threatened by infection or other danger. Salicylic acid (SA), let's see, it has been a while since chemistry class. Oh yeah, it is related chemically to aspirin! According to the director of the study, B.W. Poovaiah, it has been known that plants make SA for quite a while (> than 100 years), but the role of calcium in telling a plant to make SA has been unknown up to now.
Wow! This is good stuff! I mean one of the biggest reasons that I chose agronomy over animal science was a remark that I remember from freshmen orientation. Animals give very specific, unmistakable indications when they are not feeling well or under stress. Plants, well let's just say that they are often more subtle about it. But this article helps us understand that they too are not passive about putting together a defense plan to ward off infection.
The downside? Plants that have high levels of SA will be very resistant to infection, but have slower growth. Plants with too little SA will grow very rapidly, but are susceptible to infection. Makes sense, many things in life & nature follow the rule that some is good but too much or too little causes problems.
Another great reason to make sure that you don't neglect calcium nutrition when finalizing your crop plans for 2009. SuperCal 98G & SO4 are both great sources of calcium, that's why they are called Super! Why not try some today & give your crop a head start (but not a headache).
The Blogronomist is maintained by Craig Dick, head blogronomist and VP of Sales and Marketing. Here you will find a wide array of blog articles from Craig and expert guests on topics related to soil and crop health, farming, and so much more. If it's not here, ask us!
Additional Info
- Article Reference:: Calcium Products, Inc.


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OpenOffice Password Recovery is a great tool for any user of OpenOffice software. With its friendly interface and a choice of advanced attack methods, it enables instant recovery of passwords and protection removal for any OpenOffice document.
This software is not reviewed yet.
Excel Password Recovery Wizard provides you with a friendly interface to recover Excel passwords in a flash. The built-in attack profiles enable rapid password recovery with only one key press. Recovery success is guaranteed.
An absolute essential for every Outlook user. Restore passwords and account information instantly. Outlook Password Recovery is for those who love choosing long passwords... and then forget them!
A reliable utility for recovering lost passwords, Access Password Recovery is a Must-Have tool for every user who has to deal with Access documents. A wide variety of security and administration services is provided by this easy-to-use program.
Have you ever forgotten a password for your MS Access database? Whether you have or haven't, you'll appreciate this solution to all lost password problems from restoring passwords to performing security audits and other administrative tasks.
Now it's no longer necessary to remember countless passwords for dozens of Outlook accounts and PST files. What is necessary for every user is PST Password Recovery. Install it, and forgotten passwords can be restored in a snap!


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Destiny Quest Library Catalog
Destiny Quest allows you to search for books, DVDs, audiobooks, ebooks, and even digital media that the district provides through all 8 of the Wilson libraries.
World Book Encylopedia Online
The World Book Online Encyclopedia is available with no login when your computer or mobile device is on school property. For home access, please ask your teacher-librarian or see the Wilson Libraries Passwords link.
This searchable database is useful for quick access to accurate, reliable information. A full MLA citation for each article is at the bottom of each web page
World Book Early World of Learning App
Reading Olympics Book List for 2017-2018
Below is a link to the list of NEW books for the 2017-2018 Reading Olympics.
This MAIN PAGE has resources for EVERYONE to explore. Spend some time looking around.
There is something for everyone to use both for education and research and just plain fun!!
Library Media Specialist
Rachel Schultz
Library Technology Assistant
Mrs. Kerry Vath
Kid's POWER Library
A POWER Library webpage dedicated to serving kids is now available. Kid-centered e-resources, Chat with a librarian, Books, movies, and more, and PA Photos and Documents, are now presented in a single, kid-friendly interface.
Access BOOK FLIX, Searchasaurus, eBooks and even chat with a librarian for help
POWER Library - WH
Click on Power Library symbol above for ALL of Power Library resources.
This link will take you to directly POWER Library from school.**
*****REMEMBER If you are at home, please go to your public librarywebsite and
login with your library card number to use
POWER Library's resources.
MackinVia Ebooks
MackinVIA is a complete digital resource system providing easy access to eBooks, audiobooks, databases and videos. With just one login, users can view, utilize, and manage all of their digital resources. Further, MackinVIA is mobile friendly.
The MackinVIA Reader app allows MackinVIA users to check out and download eBooks and includes features such as keyword search, bookmarking, and annotations. Users can highlight text in multiple colors. There are three levels of the popular Merriam-Webster dictionary as well as citations by EasyBib. Through the use of the app, users are able to download eBooks hosted by Mackin Educational Resources for offline reading.
Subject Guide
Contact Info
610-670-0180 x 1620
Send Email
Profile & Guides
Whitfield Elementary Librarian
Whitfield Library on Facebook
Capstone Interactive Books WH
eBooks Link
We have a wonderful new collection of eBooks in our library collection.
Click on the picture and explore. All books are able to be read aloud and have a follow along option.
Fiction and Non-Fiction titles are available. You can use your computer, tablet, eReader or Smart phone to read these books.
Starfall Audiobooks
Whitfield Passwords
Forgot your password?
Click below and sign-in to Google Apps to view the list of usernames/passwords for the Whitfield Library Resources.
In order to view the document, a student will need to sign in with their school username/password.
Print a copy to keep near your computer at home.
Whitfield Library Resource Username/Password List - for Students
Wilson Library Resources Handout for Teachers


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Today's backbench business debate was an opportunity for MPs to discuss the government's TB eradication programme, the NFU said today. A vote of 147 to 28 MPs saw the motion carried that the house "notes the e-petition on the planned badger cull, which has gathered more than 150,000 signatures; and calls on the Government to stop the cull and implement the more sustainable and humane solution" to problem of TB.Following growing public, scientific and political opposition to the badger cull, the government announced a halt to the programme which was to commence in Somerset and Gloucestershire this month.A record number of signatures were gathered against the cull in the Number 10 e-petition in just two weeks.The number grew to nearly 160,000 which prompted the debates in the Commons today."This debate offered a fresh opportunity for the serious issues of bovine TB to be re-examined" said NFU Deputy President Meurig Raymond who listened to the debate from the public gallery.Raymond, who listened the Commons debate from the public gallery, said the NFU remained committed to the badger cull programme for England."TB is one of the biggest single threats to our beef and dairy farms. To be successful, all of the most recent science shows that tackling TB needs a comprehensive programme of measures that attacks this terrible disease from all sides.""And the key conclusions in the 2011 report from the meeting of scientific experts says that reducing badger numbers will help to reduce TB in cattle by an average of 16 per cent" he said.The RSPCA, however, expressed their 'delight' over the English badger cull delay which was made on Tuesday."Hopefully it marks the beginning of the end for these unscientific, foolish and cruel plans to cull badgers. We welcome this postponement, but this must not be a temporary reprieve, but must mark an end to all cull plans" said RSPCA Chief Executive Gavin Grant."Science, the public and MPs from all parties had said very clearly that a cull is no answer to bovine TB" Grant concluded.The NFU accused the RSPCA of hypocrisy earlier in the month after farmers were warned that they could lose their valued Freedom Food status if they supported or allowed badger controls on their land.NFU Director of Policy Martin Haworth said: "It looks to us like the RSPCA trying to attack farmers' businesses financially to try to stop farmers from lawfully participating in what is a sadly necessary step to tackle a devastating animal disease, just as the RSPCA has tried to do by calling on shoppers to boycott milk produced on dairy farms in the cull areas."Meurig Raymond said tight cattle controls and increased bio-security on farms were already in place."Additional cattle testing will also be in place by January and we currently cull all cattle that test positive for TB.""This meant 34,000 cattle were slaughtered before the end of their productive life in Great Britain last year alone. Farmers are doing everything they can to protect their herds from TB but in the meantime the disease continues unchecked in the surrounding wildlife" Raymond said.The NFU wrote to Environment Secretary Owen Paterson to request that the pilot badger culls in West Somerset and West Gloucestershire go ahead in 2013.The request followed new survey results which revealed higher than anticipated badger numbers in the two pilot areas.Following a thorough assessment of their current capability, the NFU this informed Defra that in light of these new figures they could not be confident of removing the required minimum 70 per cent of the badgers in the two pilot areas this autumn."We know from the evidence that exists that no other country in the world has got on top of TB with cattle control measures alone when the disease has a stronghold in the wildlife as it does in England. So we do need to tackle the reservoir of TB in badgers, the proven source of TB infection in cattle" continued Meurig Raymond. "Let me be clear. We have to begin to control this disease now. TB is getting worse not better, cattle being slaughtered are doubling in number every nine years. While the vaccination of cattle and badgers will have a part to play, again we have heard today that we are years away from either making a significant contribution to reducing the prevalence and spread of TB. We do need to continue to invest in research for a workable cattle vaccine and an oral vaccine for badgers too but while we sit and wait we condemn tens of thousands of cattle to death every year and farmers and their families to untold misery. "Including badger controls, as part of the current TB policy, is regrettable but absolutely necessary if we are to start now to control TB and ultimately eradicate the disease from our beef and dairy herds once and for all."
1 FarmingUK Comments


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Californian gore metallers Autopsy burst onto the scene in 1987 with almost immediate infamy. Frontman Chris Reifert was already a well known force on the underground through his time as drummer with Florida's highly respected death metal combo Death. Released in the autumn of 1995, Autopsy's then fourth and final album 'Shitfun' was a glorious scatological gross out and a fitting end to one of the finest bands of a Doomed generation, before their return from the grave in 2009 to wreak havoc upon a new generation of gore-fiends.
Cat No: CDVILED49
Barcode: 801056704924
Packaging: CD Regular
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0entrue07/12/2006Jean-Pascal Tricoire invited to intervene during the Microsoft event

 	 Microsoft Vista Worldwide launch event: The biggest Microsoft launch of its history!

 On November 30, Microsoft officially launched a new bundle of technology of which its Windows Vista operating system and Office 2007. During this event, Microsoft has chosen Schneider Electric as a best practice to illustrate the use of Microsoft innovation. Jean-Pascal Tricoire, Chairman of the Management Board and CEO of Schneider Electric, was the first guest to intervene in front of an audience of 400 CEOs from France biggest companies. Until the end of this year and beginning of next year, Microsoft and Schneider Electric will also communicate together on a global scale, with case studies, presentations, videos and so on.
A long-term valuable partnership

 For more than 2 years now, the Customer Software entity of Schneider Electric and Microsoft are working closely together on software development and on innovation towards the same objective: Create more value for the users.

As Microsoft was about to launch a new bundle of technologies including Vista, they offered to Schneider Electric the possibility to jointly develop a proof-of-concept software based on future technologies.

A software was chosen as a test. This software is still in development. It will be a software for our OEM customers.


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From the June issue: The Brooklyn neighborhoods outside of the borough's Downtown business hub are having their own office party.
Many of those neighborhoods are seeing a quiet but significant uptick in small office properties available for rent, as Brooklyn continues to reap the benefits of higher rental rates, new ground-up construction and more conversions. [more]


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Bitter Halo
Drist's first full length effort. Released in 2003. A great blend of heavy and melody. Mixed by Ulrich Wild (Deftones, Static X, Rob Zombie, Incubus, Breaking Benjamin) Want to know more???? Check out the reviews. Chris Koenig - Drums Dave Pearl - Bass Brain DaMotta - Guitar Tyson Yen - Vocals Additional Guitars by Josh Stinson.


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Louis Cruises today unveiled summer savings of up to 30 percent off published rates on the line's new "Highlights of Greece and Turkey" itinerary.
With prices starting at $707 for sailings of July 01, 15 & 29, September 09 & October 21, $767 for the sailings of May 06 & 29, June 03 & 17 and August 12 & 26 and from $797 for the September 23 and October 07 departures, travelers can explore the treasures of the Aegean on this 8-day/7-night cruise onboard Louis Cristal that includes the newly added destination of Izmir (gateway to Pergamum), Turkey as well as extended visits in most ports-of-call, including full-days in Santorini and Crete.
The novel "Highlights of Greece and Turkey" is an 8-day, 7-night cruise program that commences and concludes in Athens and showcases intriguing destinations throughout the region. Travelers embark in Athens' Port of Piraeus then cruise to Istanbul and Izmir in Turkey – each for a full-day. Mykonos welcomes guests as the next leisurely stop on this exciting itinerary. The adventure continues with a morning in the Greek Island of Patmos and afternoon to discover Kusadasi (gateway to Ephesus) in Turkey. Sailing along, travelers enjoy full-day stays in Santorini and Heraklion (gateway to Knossos), Crete where they will experience the beauty and diversity of these distinctive Aegean isles before returning to Athens.
"Highlights of Greece and Turkey" Summer Sale rates are valid for new bookings (as of May 16, 2011), based on availability, and feature savings of $270-$690 per person based on the cabin category selected. Prices are per person, double occupancy. Children 16 years of age or younger staying in the same cabin with two paying adults sail for FREE, and pay only applicable port charges. Port charges, security and other service fees of approximately $222 and $24 fuel surcharge per person are not included in starting prices detailed above.


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"Protest Posters" Reviewed5.16.13
The New Haven/Hartford Advocate has reviewed "Artists Take Action," an exhibition at Wesleyan's Davison Art Center that showcases posters by Justseeds, Occuprint, and Meredith Stern's "This is an Emergency" project.
What happens when an explosion of creativity meets a passion for politics on the front lines and in the streets? Pretty much what you find at Wesleyan University's Davison Art Center, in a small but splendid exhibit of contemporary protest posters called Artists Take Action, on view until May 26 in Middletown. They are all a part of what cocurators Clare Rogan and Suzy Taraba call "a resurgence of protest posters today."
The left-leaning posters, created by more than 80 artists, mostly from the U.S., are taken from four portfolios published by artists' cooperatives around the country, including Booklyn Artists Alliance and Justseeds Artists' Cooperative.
Read more here.


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Vampire Costume Teeth
Vampire Costume Teeth Gender: Unisex Age: Adult Type: Prosthetics Theme: Prosthetics Size: One Size Color: As Shown
Where to buy
- $0.99
Find the best deal for Vampire Costume Teeth sorting the prices, lowest to higest and/or higest to lowest. Chose the store before you read the seller ratings. The merchants are responsible for providing GoShopping.com with correct and current prices. Although we make every effort to present accurate information, we are not responsible for inaccuracies.
Technical Details


text: Two weeks ago when I did my Haunt Jaunt of the Week segment on "Keeping the Spirits Alive!", I spoke about a great place to find the ghosts of Christmas Past: Jekyll Island. What I meant by "ghosts of Christmas past" was a historic place dedicated to bringing the Christmas


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Size of baby: 2.5-3lbs and 17 inches- About the size of a Chinese cabbage
Symptoms: The heartburn was pretty much nonexistent this week but after that 8 hour plane ride my back has been destroyed for the past 3 days.
Fetal Movement: lots and lots! love it!
Sleep: between the jet lag and sleeping in different beds, not so good.
Maternity Clothes: Shopping for maternity clothes was a bust. Maybe my belly isn't big enough for maternity clothes yet but it all looks terrible on me. I'll just stick to the same few outfits that still fit me for now I guess.
Cravings: Well I'm finally getting my fill of Mexican food!
Best Moment of This Week: Getting to Texas and spending time with family!


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Do I have to release my customized open source code?
If I use open source software and make changes to it, am I required to release the code?
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Europe › Netherlands › Aalden › Aalden Hotels
Landal Aelderholt
Aelderholt 4 7854 TZ Aalden, Aalden, Netherlands
www.landal.nl/nl-nl/bungalow… - +31-(0)591-371 919
Landal Aelderholt Aalden Reviews
17 reviews
Great scenery and very quiet Nov 13, 2009
Landal Aelderholt is located in the province of Drenthe. The scenery is beautiful and the park is very clean and tidy. The park is located near the village Aalden.
The region is a great place for cycling and walking. The famous "Hunebedden" are nearby. The nearest city is Emmen where you can visit the Zoo which is one of the best Zoo's in The Netherlands. The park has many facilities, there is a restaurant, snackbar, golf course, minigolf, playgrounds, laundry facilities and a nice swimming pool. There is also an entertainment team and there are activities every day for children and adults.
The bungalows are spatious and clean and give enough privacy. Every bungalow has internet access, television and a fully equipped kitchen.
2 / 2 TravBuddies found this review helpful/trustworthy
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Welcome to the ICL-GNSS event homesite!
ICL-GNSS is an annual conference, held, for its 3rd edition, in Turin, Italy, from the 25 to the 27 of June 2013.
The conference is focused on localization and Global Navigation Satellite Systems. It provides a high-quality publishing forum with peer review, and emphasizes at the same time quick turn-around time.
Driven by both market trends and legal regulations, there is a high demand for providing a robust localization solution, which will be available continuously, regardless the specific environment, i.e., outdoors and indoors, and on different platforms such as stand-alone navigators, PDAs and mobile devices. ICL-GNSS thus addresses both satellite-based and complementary technologies.
The event is based on contributed peer-reviewed papers and will include world-class invited keynote presentations.
Click here for the Call For Papers and submission instructions.
The local organizer for the event in 2013 is the NavSAS group of Politecnico di Torino and Istituto Superiore Mario Boella
For more information, please email Dr. Fabio Dovis (email@example.com)


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J Bridal Boutique is an "Ultra Chic" Bridal Boutique located in Plaza Colonial in the beautiful Foothills of Tucson, Arizona.
Founded by Emily and Katie, "Sisters On A Mission", to offer women in Tucson a bridal shopping experience like no other.
Emily and Katie, along with their best friend, Genna, had first dreamt of opening a bridal boutique while shopping around town for Emily's wedding gown in 2010. The search around Tucson was unsuccessful, so they decided that this called for a girls trip to Scottsdale. After an adventurous day, the last place on the agenda absolutely blew the girls' minds. Not only did Emily find "the ONE", the experience was amazing! On the drive home that evening the girls could not stop talking about how Tucson desperately needed a bridal boutique that offered this same unforgettable experience. They discussed all the details and how their boutique could be and the roles each of them would play.
Reality set in as the idea seemed too far-fetched.
On June 26, 2012, Emily and Katie received news that Genna's life had tragically and unexpectedly ended. The heartbreak was unbearable, but Emily and Katie were determined to honor their best friend in some special way. They came back to the idea of how amazing it would be to open a bridal boutique in her name and shared the idea with investors, mother Suzan and father Richard, and they loved the idea.
As an opportunity presented itself, there was no looking back! The Freibert family would finally be able to turn what was once a dream into reality.
J Bridal Boutique represents beautiful, Genna.
Although Genna's name does not begin with a "J", it was a nickname given to her by someone very near and dear to her heart. She would express how much she loved being called "J" and how special it made her feel.
J Bridal Boutique is conceptually designed by Emily, Katie, and their mother Suzan.
Suzan has a background in fine art and has explored watercolor, pastels, and writing poetry. She has always taught Emily and Katie to express themselves through imagination and creativity. The trio is incredibly thankful and excited to work together, bringing Tucson a unique bridal experience.


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I stifled a groan and rubbed my face wearily as an exasperated sigh escaped me. What, I wondered, had I done to deserve this? What could I have possibly done that was so horrible, so wicked, so terrible, that as punishment I currently had all eight of the Cullen children sitting in my office, waiting for their parents to arrive and deal with them?
The Cullen children had been sent to my office, their parents called, and I was dreading this, dreading the meeting with parents we had never seen, never met. Dreaded discussing not only the things the children had done today to be sent here, but also the other odd things that needed mentioned. Like Rosalie's attitude, or Emmett's grades. Or the amount of school they tended to miss. Or the fact that the parents had never seemed even slightly involved or interested in how their children were doing in school.
I looked over at where they all sat in a row, on the bench outside the principal's office, my office, against the wall across from the door. It was like looking at some sort of television show, with stars who seemed perfect on the outside, but in reality hid some deep, dark secret from the world.
To the far right, first to be dealt with when the elusive parents arrived, was Edward Cullen. He sat staring out the window, watching for his parents, I guessed, a slight smirk on his face, although he still had that worried, tense aura about him that students tended to have when sitting in the seat he was currently in.
His arm was around Bella Swan, who was both his age and in his year. She too was nervous, worried, but kept shooting glances at one of the others further down the line. She was a good student, quiet, never any trouble, and kept to herself. Most of the Cullen children kept to themselves.
On her other side was Jacob Black, tall and dark. One of the two out of the bunch who didn't seem deathly pale or completely exhausted. He was probably the most normal out of the group, once you got over his size. Your average high school student, getting into trouble now and then, but nothing serious, and nothing that wasn't in good fun or good spirits.
Paler than Jacob, yet darker than the others, Reneesme Cullen sat to his left, nose buried in one of her textbooks. She was less outgoing than Jacob, though more so than the rest of her siblings. She seemed to enjoy reading, and learning. She seemed to be one of those kids that actually liked school.
Beside her was Rosalie Hale, one of the twins. She was arrogant, haughty, and had an attitude that had put most of the staff off of her from day one. She was unfriendly and unkind to those who crossed her path, often with hateful words even for her siblings. She sat brooding, clearly resenting her current situation.
Emmett Cullen, on the other hand, didn't seem to mind, but then again, he didn't seem to mind much of anything. He was probably not the brightest out of the bunch, and in fact his grades were barely acceptable. He seemed to have a real problem with schoolwork, getting it done or, when he did complete it, getting it right. He was barely passing, and, in fact, very close to failing. He sat beside Rosalie, staring idly into space, a twinkle in his eye.
Next to him was the smallest of the Cullens, Alice. She was quiet, unless with her siblings, when she became immensely talkative. She was friendly, and did well in her classes, but there was something about her that just seemed off, and it worried me. On occasion she had been caught in class, eyes unfocused, unseeing, her mind completely elsewhere. It had not happened often, but it had frightened both of the teachers involved considerably. Her attention was focused on the last of the gang, her hands holding one of his as she murmured softly.
Jasper Hale, the other twin, was quiet, intense, and withdrawn. He did his work, but rarely spoke, and often seemed troubled or distressed by something. He sat now with his head leaning against the wall, his eyes closed, his jaw clenched. He held a book tightly in his other hand.
Edward shifted ever so slightly, and suddenly the parents were here. Carlisle Cullen entered first, the doctor who spent a large portion of his time at work, and so had never actually made it to the school before for anything. The doctor who let his children skip school whenever they pleased. He didn't seem particularly concerned to see all eight of his adopted children parked outside of the principal's office, either.
His wife followed close behind, her expression annoyed, as she and her husband approached me. They were both very young, and I doubted they were actually responsible enough to handle eight children, even if they were rich, and wondered what had made the Cullens adopt them all.
He spoke softly, calmly, as if he were merely here to make a social call. "Good morning." He greeted me cordially. "You must be Mr. Richards." He was dressed for work, and I wondered if he had been on his way out the door when I called. "I'm Carlisle Cullen, and this, of course, would be Esme, my wife." She moved closer to him as he introduced her, and his arm slipped around her waist.
I nodded. "Doctor Cullen." I replied formally. "I spoke with your wife over the phone. I imagine you know why I asked you here?"
"I understand it has something to do with my children's behavior." He admitted, still as pleasantly as if we were sitting around drinking coffee. I cleared my throat. "Yes, well, we seem to be having some problems with them today, problems that need to be addressed."
Cullen nodded easily. "Of course." He said.
We stepped into my office, and I called for Edward to join us. Bella followed him in, and the two of them stood before the three of us, she nervous, he unconcerned, as Cullen completely ignored me to speak directly to his son.
"What happened, Edward?" He asked.
Edward shrugged. "Mrs. Acres caught Bella and me passing notes." He said easily. "Since he made it very clear at the beginning of the semester that it was not allowed, and since there has been a large increase in note passing lately, he decided to make an example of us."
Cullen didn't seem fazed. "I do expect you to abide by the rules your teachers have set forth, Edward." He said easily. "I don't want to hear you've been caught breaking the rules again.
Been caught. The words echoed in my mind. Cullen didn't care if his children broke the rules, as long as they didn't get caught. Great. But then, I don't know why I was expecting him to actually worry about his children.
Edward frowned slightly as he nodded. "Yes, sir."
"I expect you to apologize." Cullen added, much to my surprise.
Edward nodded again. "Of course." Bella quickly nodded as well.
"Yes, Carlisle." She said softly.
They were out the door before I could say another word, and the only choice I had was to call in Jacob Black.
He rolled his eyes as he came in. "Dr. Fang." He greeted Cullen brightly.
"Jacob." He replied, apparently used to the irreverent and rather odd greeting.
"I know, I know." He said quickly, before any of us could speak again. "But here's what happened. So I was sitting in class, minding my own business, when these two guys were sitting behind me, and they were talking, and I happened to overhear." Cullen was waiting patiently, as if he were unaware of Jacob's stalling techniques. "And they were talking about Nessie. You know, like boys do." As if he weren't a mere boy himself. "And I didn't think any of it was appropriate. So I turned around, and-" He broke off, looking towards Mrs. Cullen, "hey, I didn't hit them or anything. I just knocked their table over. Sent their stuff everywhere. Made this loud noise that about made everyone jump out of their seats." He shot a defiant look at Cullen. "They didn't need to be talking that way."
Cullen didn't look too upset. "Violence isn't the answer, Jacob."
"Sometimes it is." Jacob replied. "And besides, that wasn't actually violence. It was a warning, to prevent violence." Because next time it happens, there will be violence. The thought was left unspoken, but was plainly understood.
"They're teenagers, Jacob." Carlisle reminded him mildly. "You know what teenagers are like."
For a minute I thought he looked embarrassed, but his expression cleared. "So what, you want me to apologize for disrupting class, promise not to get into any fights at school, that kind of thing?" He asked. "Consider it done. Can I go now?"
He was out the door in a flash, and my head was starting to spin as Reneesme swiftly took his place. I was also starting to get irritated with Cullen's method of 'dealing' with his children, and the fact that his wife seemed content to let him continue in this way.
She closed the book carefully. Then she smiled brightly. "I'm not in trouble Gr- Carlisle. I just asked to go the bathroom and wanted to make sure everything was okay." She turned to look at me. "May I go back to class now?"
Feeling rather confused, as if I were missing something, I nodded, and she slipped out the door. Rosalie and Emmett came in next, Rosalie still in a temper.
This was going to be fun.
Rosalie glared at Cullen. "This is stupid." She complained. "Nothing happened."
Emmett grinned at Cullen mischievously. "The teacher said we needed to let our overactive hormones calm down. So she sent us to here together." He snorted.
Cullen sighed so softly I almost didn't catch it. "I believe we've already talked about this before."
"We aren't related." Rosalie snapped. "Nobody cares if Johnson and that girl hang off each other. Just because-"
Cullen interrupted her, much to my surprise, though it was with the air of one carefully choosing his next step. "School isn't the time or the place for it." He said gently.
She shrugged. "Fine." She turned to glare at Emmett. "He started it."
"Sorry." Said Emmett, not sorry at all. "Sometimes I have trouble controlling all those overactive teenage hormones, Carlisle. You know how it is."
I was absolutely appalled at how things were going so far, and at how easily Cullen seemed to take these things in stride. He didn't seem the least bit concerned with the behavior of those two. I wondered what sort of things went on at home, but then, he probably wasn't home much either. He struck me as the typed of person who spent most of his time at work. It made me feel sorry for his wife.
She hadn't spoken a word during all this time, but had merely stood beside him, watching. I wondered how much say she had in the raising of these children, if there were any raising going on at all. It was entirely possible that the Cullen gang merely did as they pleased when at home.
Alice danced in next, looking, unlike the rest of her siblings, properly ashamed of herself. She slumped her shoulders and hung her head. "I'm sorry, Carlisle." She said quickly. "I shouldn't have said it, she didn't deserve it. It wasn't nice, or appropriate, and completely unacceptable. I'll apologize as soon as possible, and it will never, ever happen again." She said quickly. Then she hung her head even lower, if that were possible, as she confessed her crime. "I called Mrs. Matthews a-"
The words that next came out of Alice Cullen's mouth were enough to make Cullen and his wife's eyes widen and their mouths drop open, never mind the shock I was experiencing. I was appalled, and amazed, and well, surprised to think she even knew such words.
"Where did you learn that?" Mrs. Cullen demanded, speaking for the first time. "Did you hear that from Emmett?" She asked.
"Esme." Cullen said quietly, as Alice shook her head.
"No, Carlisle." His wife insisted grimly. "I want to know where she heard such filth. I wasn't aware some of those words existed."
Alice sighed. "I am sorry." She said. "And it doesn't really matter-"
"It does matter." Esme insisted. "Does Jasper know you know such language?"
Alice looked extremely embarrassed, and I had the strangest feeling I had been forgotten for the moment. Under Mrs. Cullen's angry gaze, she finally broke. "Jasper was the one I heard it from." She whispered miserably.
Both parents stared at her for a moment. "I'm sorry. You can ground me from shopping; make me wear old rags for a month. I deserve it." She ducked out, leaving them standing there, staring after her.
When Jasper Hale did not immediately make an appearance, I stepped out into the hall to call him in. He and Alice stood facing each other, Alice on tiptoe, her arms wrapped around him, whispering into his ear. The two seemed oblivious to all else.
She kissed him lightly on the cheek and sat down on the bench. I cleared my throat. "Get to class, Miss Cullen." I told her.
She looked up at me with wide eyes. "Would it be alright if I waited until Jasper was done?" She asked. "I wanted to talk Carlisle something."
Jasper darted into the office as she spoke, and so I nodded quickly, not eager to be left out of another discussion, and followed him.
He actually made use of the chair sitting before my desk, eyes on Mr. and Mrs. Cullen until they too sat down. I sat down as well, on the other side of the desk. This was the way things were supposed to be done.
Mrs. Cullen broke the silence. "First things first, young man." She said firmly. "Alice said she learned those awful words from you. Where did you ever hear such language?"
He sighed, but looked more angry than ashamed. "It slipped out. Once, in a very tense situation. It was a long time ago" He admitted. "I don't usually hold with making use of such filth." He paused, shooting a glance at me. "Maria used to talk like that when people made her angry." He shrugged. "I hardly expected Alice would make use of it, especially not in a school."
I cleared my throat. This was all well and good, but it wasn't the point. We were supposed to be dealing with Jasper's behavior now, not Alice's.
Doctor Cullen nearly sighed. I'm sure of it. "Jasper?" He asked.
Jasper shrugged. "I refused to work on the given assignment. We're reading a book in literature class, and I haven't done anything since he assigned it. It's just, today we were supposed to take turns reading some of it aloud, and I refused to participate. So he said I could stay and do my work or go to the office. I didn't wanna be there anyway." Maybe it was my imagination, but there seemed to be some sort of accent on his words, as if he were drawing them out.
Doctor Cullen seemed puzzled. "I assume there is a reason behind this decision?" He asked.
Jasper shrugged, and tossed the book he had been holding. Doctor Cullen caught it neatly, and examined it. "Kiss of Darkness." He read the title, then flipped it over to read the back. "Vampires?" He asked with a small frown as he read. Jasper nodded. "You've read Dracula, Interview with a Vampire…" He trailed off. "What makes this one different?"
"The first page." Jasper replied shortly. Doctor Cullen opened the book and began reading.
"I watched in silence, both horrified and fascinated, as the scene before me unfolded." Jasper went tense, his jaw clenched, his eyes closed, as he sank back into his chair. Doctor Cullen continued reading. "The man, tall and pale, had drawn the woman closer and closer to him, luring her in with promises of romance, of love, of pleasure. He had spoken softly, sweetly, and she had ignored those instincts that should have warned her to keep away, that he was anything but safe. She stood mere inches away from him now. He leaned forward, closing the gap, to kiss her tenderly upon the lips, his kisses trailing along her jaw and down her throat, until at last, as I had known he would, he bit.
"He drank greedily, drawing from her the blood, warm and sweet-" Doctor Cullen broke off, looking completely horrified. He blinked, and swallowed rapidly, then cleared his throat. "Forgive me. I can see why you would be averse to reading it." His voice sounded slightly strained. "I don't expect you to." He turned to me. "I don't want him reading this. Or any of them, should it come up." He told me matter-of-factly.
I was a bit surprised by some of the content myself, but after all, this was a senior class, and while the lit teacher did have a tendency to introduce some interesting literature, he always had a reason behind his choices, and usually had parents sign off their approval of the year's reading list with the beginning of the school year.
I opened my mouth to tell him this, but stopped as I realized I was again being ignored. "Why didn't you say anything?" Doctor Cullen was asking Jasper, who merely looked at the floor, his body tense. The Doctor sighed, then turned to me. Perhaps I had not been forgotten after all. "I don't want him reading this." He repeated.
I sighed. Doctor Cullen was starting to annoy me. "Every other student in his class is reading it, and no one else has a problem with it. He can read it too."
"I would hardly consider this appropriate material for children-" I cut him off.
"They are seniors." I snapped. "They are hardly children any more. They are preparing to go out into the real world, and they have to learn to deal with things. Your son is no exception. He can read the book like everyone else." I was tired of letting Doctor Cullen and his wife push me around. It wouldn't kill Jasper to read the book.
Cullen's eyes flashed, and for less than a second I was afraid. Very afraid. Visions of him leaping across the desk to rip my throat out with his bare hands played briefly through my mind. Then it was as if it had never happened, except that Cullen's easy manner had been replaced, he sat tense, and determined, leaning forward in his seat. Jasper leaned forward to lightly touch his father's arm.
"I have already said he will not be reading it." Cullen said, his voice low and even. "Nor will any of my other children. If there is a problem with that, I will pull all eight of my children out today and home school them myself." His golden eyes held mine. "Your call."
He was serious. Dead serious. He wasn't joking, and he wasn't bluffing. I had no idea what the big deal was, but I wasn't willing to have the Cullens pulled out of the school over it. I sighed.
"I will talk to the literature teacher," I said at last, "and we will see if we can work something out for him to read instead." Cullen relaxed, and I found myself breathing a sigh of relief. He was his, well, normal easygoing self again, if the man could be considered normal.
"Very well, then." He said, as if nothing weird had ever happened between the two of us. "That would be satisfactory." He stood, as did his wife, and Jasper as well. "Would it be alright if we took Jasper home?" He asked politely. "He seems a bit shaken up over this."
Jasper swallowed, but otherwise did not respond. Why not? "Certainly." I said. That would be one less to worry about for the rest of the day.
"Thank you." Cullen nodded briskly. "Sorry for all the trouble. I expect the children will be on their best behavior from here out."
"I hope so." I said earnestly. I really did.
"Good day to you." He said, excusing himself, and his wife, and his son. Alice met them in the hall with Jasper's school things; I wondered how she had known he would be leaving. Their eyes met, hers and his, and lingered for several seconds, then she was skipping off to class, and he was leaving with their parents.
I shook my head as they left. I had wondered why the children had seemed so odd. Now I knew.
I hoped fervently that I would never be faced with such a situation again.
Disclaimer: Say it with me, 'Twilight does not belong to me.' Now you know, and I know, and you know that I know, and I know that you know, and they know that we know, and we know that they know...


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My grades are slipping in school. My dad told me I should consider just not going to college at all and going straight into the work force. Whenever he says that I get short bursts of motivation that last maybe a month if the kick in the pants is really really strong.
Don't just tell me that I'm going to be a loser for the rest of my life because I want to get somewhere but just reminding myself of my future being in jeopardy isn't enough to put a fire in my gut. I need new sources of spark.
Most Helpful Girl
I got it from myself, one day I decided to stop slacking off and start working harder in school so I can get into college and stuff. I just study hard and I don't wait till the last minute. I always get things done beforehand so I don't have to worry about it the next day. When I do good in school and bring home good grades it makes my dad so proud of me. He just wants you to succeed that's all.00|00|0


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Hello fellow Gamers, this is Cody AKA SirRoachMan bringing you a clip called Sir Roach Man Plays: Apotheon on Steam featuring the game by the same name. Apotheon which is a free game on the PlayStation 4 for those who have a PlayStation Plus membership. At first I had my doubts about this game but the more I played it the more I got hooked on it. If you haven't played it yet I'd recommend downloading it, after all, it is free.
Subscribe to SirRoachMan for more and keep an eye out for Cody on RealGamerNewz.com as well!
RealGamerNewz.com 's Full In-Depth Review of Apotheon for Steam Coming Soon, Stay Tuned!!


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Price: $22.99


text:
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Dose-dense chemotherapy has become a mainstay regimen in the adjuvant setting for women with high-risk breast cancer. We performed a systematic review and meta-analysis of the existing data from randomized controlled trials regarding the efficacy and toxicity of the dose-dense chemotherapy approach in nonmetastatic breast cancer.
Randomized controlled trials that compared a dose-dense chemotherapy protocol with a standard chemotherapy schedule in the neoadjuvant or adjuvant setting in adult women older than 18 years with breast cancer were identified by searching The Cochrane Cancer Network register of trials, The Cochrane Library, and LILACS and MEDLINE databases (from January 1966 to January 2010). Hazard ratios (HRs) of death and recurrence and relative risks of adverse events were estimated and pooled. All statistical tests were two-sided.
Ten trials met the inclusion criteria and were classified into two categories based on trial methodology. Three trials enrolling 3337 patients compared dose-dense chemotherapy with a conventional chemotherapy schedule (similar agents). Patients who received dose-dense chemotherapy had better overall survival (HR of death = 0.84, 95% confidence interval [CI] = 0.72 to 0.98, P = .03) and better disease-free survival (HR of recurrence or death = 0.83, 95% CI = 0.73 to 0.94, P = .005) than those on the conventional schedule. No benefit was observed in patients with hormone receptor–positive tumors. Seven trials enrolling 8652 patients compared dose-dense chemotherapy with regimens that use standard intervals but with different agents and/or dosages in the treatment arms. Similar results were obtained for these trials with respect to overall survival (HR of death = 0.85, 95% CI = 0.75 to 0.96, P = .01) and disease-free survival (HR of recurrence or death = 0.81, 95% CI = 0.73 to 0.88, P < .001). The rate of nonhematological adverse events was higher in the dose-dense chemotherapy arms than in the conventional chemotherapy arms.
Dose-dense chemotherapy results in better overall and disease-free survival, particularly in women with hormone receptor–negative breast cancer. However, additional data from randomized controlled trials are needed before dose-dense chemotherapy can be considered as the standard of care.
Dose-dense chemotherapy has become a mainstay regimen in the adjuvant setting for women with high-risk breast cancer.
Systematic review and meta-analysis of 10 randomized controlled trials that compared dose-dense chemotherapy with a standard chemotherapy schedule in women with nonmetastatic breast cancer.
Dose-dense chemotherapy results in better overall and disease-free survival, particularly in women with hormone receptor–negative breast cancer. The rate of nonhematological adverse events was higher in the dose-dense chemotherapy arms than in the conventional chemotherapy arms.
The lack of obvious benefit in patients with hormone receptor–positive breast cancer indicates the need for further prospective randomized trials of the classical conserved design in this patient population.
There was substantial statistical heterogeneity among the trials. The small number of included trials makes the outcomes more likely to have been influenced by a potential publication bias.
From the Editors
The implementation of adjuvant therapy, hormonal therapy, and chemotherapy has made a major impact on disease-free survival and overall survival in premenopausal and postmenopausal women with early-stage breast cancer (1). Unfortunately, many breast cancer patients who are diagnosed and treated properly will suffer from recurrence and ultimately die of this disease. Since the introduction of anthracycline-based regimens for the treatment of breast cancer and the demonstration of their superiority to other combination chemotherapy (1), a variety of approaches have evolved regarding adjuvant polychemotherapy, including the addition of novel drugs such as taxanes and targeted agents and the establishment of dose-intensive (2) and dose-dense chemotherapy regimens (3,4) that were based on mathematical models of human breast cancer growth (5).
Administration of dose-dense chemotherapy became possible with the introduction of granulocyte colony-stimulating factor, which allowed the chemotherapy courses to be condensed without causing unacceptable toxicity. A dose-dense chemotherapy approach using concurrent doxorubicin and cyclophosphamide followed by paclitaxel was assessed in the pivotal Cancer and Leukemia Group B 9741 trial, a phase III prospective randomized trial of adjuvant treatment of women with node-positive early-stage breast cancer (6). This trial showed a statistically significant improvement in disease-free survival and overall survival for the dose-dense chemotherapy arm and has become the cornerstone for the current therapeutic treatment of early-stage breast cancer in many centers.
The Italian Gruppo Oncologico Nord Ovest-Mammella InterGruppo trial used a similar approach to test a non-taxane–based regimen (7). Although the point estimates for event-free survival and overall survival favored the dose-dense regimen, they were not statistically significant (7). A third trial in the neoadjuvant setting failed to show statistically significant improvement in pathological response rates, disease-free survival, or overall survival for the dose-dense regimen (8). Several other randomized trials have examined the concept of dose-dense chemotherapy (9–18); however, these studies are difficult to interpret because the treatment groups differed in terms of dose density, drug regimens, number of cycles, and the application of sequential strategies.
Given this paucity of data, we performed a systematic review and meta-analysis of the evidence from randomized trials for the efficacy and toxicity of the dose-dense chemotherapy approach in the treatment of early-stage and locally advanced breast cancer.
Relevant randomized clinical trials were identified by searching the most recent update of The Cochrane Central Register of Controlled Trials (January 2010), The Cochrane Library (January 2010 issue), and LILACS (Latin American and Caribbean Health Sciences) and MEDLINE databases (January 1, 1966, to January 1, 2010). The terms "adjuvant," "neoadjuvant," and "dose-dense chemotherapy" (and similar terms) and "breast cancer" and similar terms were cross-searched by using the following search algorithm: ((dose-dense chemotherapy OR dense OR acceler* OR weekly OR bi-weekly OR biweekly) AND (Breast neoplasm MeSH OR ((breast OR mammary OR mamario OR seno) AND (carcinoma OR malignan* OR neoplasm OR tumor)))) AND (randomized controlled trial [pt]OR controlled clinical trial [pt]OR randomized controlled trial [mh]OR double-blind method [mh] OR single-blind method [mh] OR clinical trial [pt] OR clinical trials [mh] OR ("clinical trial") [tw] OR singl* [tw] OR doubl* [tw] OR trebl* [tw] OR tripl* [tw] AND (mask* [tw] OR blind* [tw]))) OR (placebos [mh] OR placebo* [tw] or random* [tw] PR research design [mh:noexp] OR comparative study [mh] OR evaluation studies [mh] OR follow up studies [mh] OR prospective studies [mh] OR control* [tw] OR prospective* [tw] OR volunteer* [tw] NOT (animals [mh] NOT humans [mh]). We also searched for relevant abstracts in the annual conference proceedings up to December 2009 for the American Society of Clinical Oncology, European Society for Medical Oncology, and the San Antonio Breast Cancer Symposium. References of selected articles were scanned for any other relevant trials, and the original trialists were contacted about possible unpublished trials.
We included in the systematic review all randomized controlled trials that compared a dose-dense chemotherapy protocol with a standard schedule of chemotherapy in the neoadjuvant or adjuvant setting in adult women older than 18 years with breast cancer. Trials were included regardless of publication status and language. Two trials in a foreign language were assessed by a native speaker (neither was included in the meta-analysis). We defined two types of trials: Trials that evaluated similar doses of agents in both treatment arms but with condensed schedule in one arm, which we designated conserved dose-dense chemotherapy trials, and trials that compared a condensed schedule with a standard one but used different agents or doses in the two arms were designated modified dose-dense chemotherapy trials. Trials in which overall survival was the primary outcome measure but was not reported were included if all other inclusion criteria were met. Authors of these trials were contacted and asked to provide data for the primary outcome measure if those data have been collected.
We excluded trials that assessed dose-dense chemotherapy in malignancies other than breast cancer or that evaluated dose-dense chemotherapy combined with radiotherapy, trials in which the definition of dose-dense chemotherapy differed from the original definition (4), trials that included high-dose chemotherapy arms with peripheral stem cell support, and randomized controlled phase II trials that evaluated toxicity only.
Two authors (LB and IBA) independently inspected each reference title identified by the search and applied the inclusion criteria. For possibly relevant articles and in cases of disagreement between the two reviewers, the full article was obtained and inspected independently by the two reviewers.
Trials that fulfilled the systematic review inclusion criteria were assessed for methodological quality by two authors (LB and IBA). Information about randomization and allocation concealment, sample size, exclusions after randomization, and the length of follow-up were recorded as is considered acceptable for Cochrane reviews (19). The same two authors independently extracted the data from publications of included trials. The data extraction was discussed, decisions were documented, and, if necessary, the authors of the trials were contacted for clarification. Authors of included trials were contacted for all data relevant to the primary and secondary outcomes of this study and quality variables.
The primary outcome was overall survival, which was defined as time from randomization to death. Secondary outcomes were disease-free survival (defined as the time from randomization to earliest occurrence of relapse or death from any cause), event-free survival (defined as the length of time from the end of treatment to the earliest occurrence of a severe side effect of treatment, cancer recurrence or progression, or death from treatment side effects or from the cancer itself) (www.nature.com/nrc/journal/v3/n7/glossary/nrc1125_glossary.html), and toxicity (defined as grade 3 or 4 hematological and nonhematological adverse events). For the analysis of toxicity, we calculated the mean number of events per chemotherapy cycle by summing all events reported and dividing by the number of cycles delivered in each trial.
Hazard ratios (HRs) and variances for time to event outcomes were estimated as described by Parmar et al. (20) and pooled according to the inverse of variance method with the use of Review Manager software (version 4.2 for Windows; The Cochrane Collaboration, Oxford, UK). A hazard ratio less than 1 favored dose-dense chemotherapy. Pooled relative risks (RRs) and 95% confidence intervals (CIs) for dichotomous data were estimated using the Mantel–Haenszel method (21). We assessed heterogeneity of the trials' results by inspecting graphical presentations and by calculating a χ2 test of heterogeneity and the I2 statistic of inconsistency. We also report the Z statistic for the overall effect (Review Manager). Statistically significant heterogeneity was defined as a χ2 P value less than .1 or an I2 statistic greater than 50% (www.nature.com/nrc/journal/v3/n7/glossary/nrc1125_glossary.html). We used a fixed-effect model to pool relative risks for toxicity except in the event of statistically significant heterogeneity, in which case a random-effects model was used (ie, the inverse of variance method and the DerSimonian and Laird method) (17).
Subgroup analyses were performed to assess potential contributions to the main outcomes. A funnel plot estimating the precision of trials (plots of logarithm of the hazard ratio for efficacy against the sample size) was examined for asymmetry to estimate publication bias. Publication bias was also estimated by the formal Begg–Mazumdar rank correlation test and the Egger test (18,22).
Sensitivity analyses were performed to assess the robustness of the findings to different aspects of the trials methodology, including allocation concealment (adequate or unclear), exclusions after randomization (reported or not reported), sample size (≤100 vs >100 patients; cutoff was adopted from routine studies in which fewer than 100 patients is considered a "small" study), and length of follow-up. All statistical tests were two-sided. P values less than 0.5 were considered statistically significant.
We identified 4869 potentially relevant articles in the primary literature search (Figure 1), of which 11 were randomized phase III trials that met the inclusion criteria and were divided into two groups based on the trial methodology. The first group—the conserved dose-dense chemotherapy trials—included three trials (Table 1), and the second group—the modified dose-dense chemotherapy trials—included seven trials (Table 2). The PREPARE trial (24) was included in the systematic review but not in the meta-analysis because no survival outcomes were provided. Chemotherapy protocols of the included trials are listed in Table 3.
A total of 3337 patients were randomly assigned in the three trials that we classified as conserved dose-dense chemotherapy trials (6–8). In a meta-analysis of these three trials, patients in the dose-dense chemotherapy arms had better overall survival than patients in the conventional chemotherapy arms (HR of death = 0.84; 95% CI = 0.72 to 0.98, P = .03), and there was no heterogeneity among these trials with respect to overall survival (I2 = 0%) (Figure 2). Dose-dense chemotherapy had a similar benefit with respect to disease-free survival (HR of relapse or death = 0.83; 95% CI = 0.73 to 0.94, P = .005), with no heterogeneity (I2 = 0%) (Figure 3). In a sensitivity analysis based on estrogen and progesterone receptor status using data from the two trials that examined disease-free survival (6,7), dose-dense chemotherapy had a statistically significant benefit with respect to disease-free survival only in receptor-negative patients (HR of relapse or death = 0.71; 95% CI = 0.56 to 0.89; I2 = 0%) (Figure 4, A and B).
A total of 8652 patients were randomly assigned to seven trials classified as modified dose-dense chemotherapy trials (11–16,23) that evaluated efficacy and toxicity of dose-dense chemotherapy in the adjuvant and neoadjuvant settings. In a meta-analysis of six of these trials (11–16), patients in the dose-dense chemotherapy arms had statistically significantly better overall survival than patients in the conventional chemotherapy arms (HR of death = 0.85; 95% CI = 0.75 to 0.96); heterogeneity in overall survival among the trials was low (I2 = 15.5%) (Figure 2). Dose-dense chemotherapy had a similar benefit with respect to disease-free survival in these six trials (HR of relapse or death = 0.81; 95% CI = 0.73 to 0.88) although the heterogeneity was high (I2 = 53.9%) (Figure 3). An analysis by receptor status was not performed because of the lack of these data. In the MA21 trial (23), relapse-free survival did not differ between the treatment arms in the estrogen receptor–positive population.
A meta-analysis of all dose-dense chemotherapy trials (6–8,11–16,23) revealed that patients who received dose-dense chemotherapy had statistically significantly better overall survival (HR of death = 0.85; 95% CI = 0.77 to 0.93) (Figure 2) and disease-free survival (HR of relapse or death = 0.81; 95% CI = 0.75 to 0.88) (Figure 3) compared with patients who received conventional chemotherapy. No heterogeneity was observed among the trials for overall survival (I2 = 0%), and low heterogeneity was observed for disease-free survival (I2 = 37%).
A funnel plot of the primary outcome revealed slight asymmetry, which may indicate a small study effect (ie, publication bias) (Figure 5). However, neither the Egger linear regression test (P = .066) nor the Begg–Mazumdar rank correlation test (P = .14) showed a statistically significant association between the study effects and the study size.
In the three conserved dose-dense chemotherapy trials, there was no difference in the number of grade 3 or 4 adverse events between the dose-dense and conventional chemotherapy arms (RR = 1.13; 95% CI = 0.91 to 1.39, I2 = 0%) (Figure 6, A). Delivery of dose-dense chemotherapy requires the use of growth factor support, which may prevent grade 3 and 4 neutropenia. We therefore performed an analysis that excluded bone marrow–related toxicity. The number of grade 3 or 4 nonhematological adverse events was higher in the dose-dense chemotherapy arm than in the conventional chemotherapy arm (RR = 1.32; 95% CI = 1.04 to 1.66, I2 = 0%) (Figure 6, B). We obtained nonconclusive results regarding adverse events in the modified dose-dense chemotherapy trials because of high heterogeneity (I2 = 95.8%). Thus, we used a random-effect model, which showed non-statistically significant higher toxicity in the dose-dense chemotherapy arm compared with the conventional chemotherapy arm (RR = 1.36; 95% CI = 0.87 to 2.13; P = .18).
This systematic review and meta-analysis shows that dose-dense chemotherapy for the treatment of women with high-risk breast cancer improves both disease-free and overall survival compared with conventional chemotherapy. The dose-dense chemotherapy approach resulted in better overall survival and better disease-free survival in trials that evaluated similar doses of agents in both treatment arms but with a condensed schedule in one arm as well as in trials that compared a condensed schedule with standard one but used different agents or doses in the two arms. The results for all trials combined were statistically significant, with no statistical heterogeneity among the trials.
The other important finding of this systematic review is the paucity of randomized controlled trials with an adequate study design, that is, trials that evaluate the same agents and doses in the conventional arm as in the investigational arm. Most of the trials included in the meta-analysis did not preserve this last characteristic, which is why we classified the trials according to their design.
Two recent trials have addressed the dose-dense chemotherapy approach. The recently published Canadian MA21 trial (23), which included three treatment arms that were anthracycline based, may provide key answers about the efficacy of the dose-dense approach with and without the use of taxane therapy. The PREPARE trial (24), which evaluated the effect of preoperative dose-dense and dose-intensified chemotherapy with anthracycline and taxane with or without darbepoetin alfa in breast cancer patients, was not included in the meta-analysis due to lack of outcome data.
Our meta-analysis of the efficacy of dose-dense chemotherapy according to hormone receptor status revealed that hormone receptor–positive patients did not benefit from dose-dense chemotherapy. This result was based on data from the conserved dose-dense chemotherapy trials; data from the modified dose-dense chemotherapy trials were not available. Nevertheless, data from the MA21 trial further support this finding. In the MA21 trial, relapse-free survival did not differ between the treatment arms in estrogen receptor–positive patients. Restricting the use of dose-dense chemotherapy to hormone receptor–negative patients may be justified, both in terms of the costs and the potential adverse events (25).
We also found that there was no increase in overall treatment-related adverse events associated with the dose-dense approach. Because a dose-dense chemotherapy schedule requires granulocyte colony-stimulating factor support, we performed an analysis of adverse events that excluded bone marrow–related events. In the conserved dose-dense chemotherapy trials, the number of nonhematological adverse events for the dose-dense chemotherapy arms was higher compared with that in the conventional chemotherapy arm. However, because of high heterogeneity among the modified dose-dense chemotherapy trials, the increase in adverse events for dose-dense vs conventional chemotherapy was not statistically significant.
The dose-dense chemotherapy approach uses prophylactic growth factor support to facilitate the safe delivery of dose-dense chemotherapy (26,27). The economic burden of this issue, as well as possible unrecognized growth factor–related toxicities, such as pulmonary toxicity, should be considered (28).
Several limitations of this analysis must be acknowledged. First, only three randomized controlled trials used the same agents and doses in the conventional chemotherapy arm as in the investigational (ie, dose-dense chemotherapy) arm. The fact that most of the included trials did not evaluate the same agents and dose in both arms resulted in major statistical heterogeneity among the trials. Second, the slight asymmetry of the funnel plot of the primary outcome suggests small study effects. Although results of the Egger and Begg–Mazumdar tests did not support the possibility of publication bias, the small number of included trials makes it difficult to distinguish a chance finding from true asymmetry. Also, the small number of included trials makes the outcomes more likely to have been influenced by a potential publication bias. We attempted to avoid such bias by searching for and including in our meta-analysis conference proceedings, databases of ongoing trials, and unpublished data.
Studies are needed to better define the patient population that will benefit the most from dose-dense chemotherapy. The concept of metronomic chemotherapy as evaluated, for example, by the Southwest Oncology Group (29) is a variation of the dose-dense strategy whereby chemotherapy is administered as relatively low and minimally toxic doses at frequent and regular intervals (30). Assessing the efficacy and feasibility of this milder chemotherapeutic approach might identify ways to integrate biological performance with the best treatment. This analysis indicates that dose-dense chemotherapy has a clear benefit for patients with hormone receptor–negative breast cancer. The lack of obvious benefit in patients with hormone receptor–positive breast cancer shown by this analysis indicates the need for further prospective randomized trials of the classical conserved design in this patient population.
The authors received no external funding for this study.
L. Bonilla, I. Ben-Aharon, L. Leibovici, and S. M. Stemmer contributed equally to this study. The authors take full responsibility for the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; and the decision to submit the manuscript for publication.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text: × Israel Chemicals ICL, a global manufacturer of products based on unique minerals, fulfills humanity's essential needs, primarily in three markets: agriculture, food and engineered materials. ICL produces approximately a third of the world's bromine, and is the sixth largest potash producer, as well as the leading provider of pure phosphoric acid. It is a major manufacturer of specialty fertilizers, specialty phosphates and flame retardants. ICL's mining and manufacturing activities are located in Israel, Europe, the Americas and China, and are supported by global distribution and supply networks.


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Az álláshirdetés lejárt.Aktuális állást talál az aktív állásajánlatok között: új keresés indítása itt
Client Service Delivery Manager, GFS - London
Requisition Number: 048599 Job Description: Responsible for overall client service and delivery across all applicable disciplines (Custody, Fund Accounting, Transfer Agency or Middle Office Outsourcing) for one or multiple clients. As a senior point of contact, facilitates and leads efforts of the service team and other internal stakeholders, coordinating resources to ensure timely delivery and issue resolution, and effectively communicating client concerns and needs to partners. Knowledge/Skills:
- The new post holder will benefit from having; · Technical knowledge of Fund Accounting service delivery · Complex client service delivery experience · Delivering on SLA through cross functional teams The competencies we seek include: · Effective verbal and written communication · Relationship management · Effective prioritisation · Organisational adaptability · Personal Accountability
- The successful candidate will be responsible for: · Being the senior client contact representing all applicable product disciplines, and provides for escalation on client queries and issue resolution. · Identifying and addressing service issues as and when they arise, including complex issue resolution. · Client service reviews and due diligence visits within each of the key product areas (Custody, Fund Accounting, Transfer Agency or Middle Office Outsourcing). · Monitoring performance against Service Level Agreements (SLAs) · Partnering with Relationship Manager, ensuring issues are communicated and escalated in a timely manner both internally and directly with the client(s) · Overseeing projects for clients, inclusive of ensuring all relevant internal and external parties are aware of ongoing projects and are held responsible for meeting their respective deliverables. · Reviewing, approving and ensuring timely publication of monthly reporting to consultants/clients · Providing support for Relationship Manager tasks such as call reporting, profitability, KYC requirements, at risk reporting, issues reporting, relationship plans, client survey administration and oversight · Carrying complex initiatives involving multiple disciplines and/or ambiguous issues · Improving efficiency, effectiveness and productivity · Demonstrating to both the business and client the value of the Client Service Delivery Manage and service model.
Külföldi munka


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As a young driver, you can expect to pay more for your car insurance to a driver that is older, more experienced. But this does not mean that you must shell out to pay for Sky high premium. Get tons of quotes is the best way to find a great deal when it comes to insurance. The insurance companies have formulas and different criteria in the calculation of rates, so that each quotation you get will be a little different. Request a lot of quotes guarantees that you will find a wide range of prices and cover options to choose from. When you compare the quotes of car insurance, make sure that you are being quoted the same coverage levels and deductibles. Always compare apples to apples.
How are the rates of the pilots in the first industrial city of the nation? The average rates for drivers married to halve from 3569 $ for the middle-aged couples for $ 1810 for the elderly. driver single male in their 20 years they may see rates of $ 3118, while single, age 35, males can view the rates of $ 2,319. However, through the three companies with the most affordable Paterson, rates of car insurance has made a dent in the 40% smaller in the financial statements of a single male in his 30s, and 51% less for a middle-aged couple married.
If you have any questions about insurance for any of your property, be sure to ask your representative or agent of the company when you are shopping around for a policy. For example, if you run a business out of your home, be sure to discuss coverage for that business. Most of the policies of the home owners cover company equipment in the home, but only up to $ 2,500 and provide no liability insurance business. Also if you want to lower the cost of homeowners insurance, you also want to be certain that you have all the coverage you need.
Before you go shopping for cheap car insurance, you should be aware that there are different factors that can influence the premiums. Insurance companies calculate the rates of Car insurance, on the basis of age, sex, marital status, location, driving experience and credit score. The number of miles driven each year, as well as the type of car that you the owner can affect rates.
The main airport can provide on-site assistance to and from flights, including wheelchairs; call the airline in advance for details. Some rental car companies offer specially equipped vehicle with hand controls, wheelchair accessibility, and other assistive devices. rail service Amtrak provides services added to passengers with disabilities, as well as a 15% discount on rates for regular travel.


text: An iPhone case has never "felt" this good (#rimshot). OK, I'll stop with the puns already. This case for the iPhone 4 from Studio Credence is fashioned from merino wool felt with a leather pocket (and strap, depending on the model). It comes in a variety of tasteful colors, and looks both tough and useful enough to be a permanent iPhone case, even for the committed bareback user.