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Examination of Witnesses (Questions 40-51)
40. Out of the 12,500 how many had genuine grievances?
(Mrs France) Well, genuine grievances
41. Did you feel had genuine grievances.
(Mrs France) I do not think I can answer whether they had genuine grievances but I can say what proportion we decide on the papers rather than investigating. Now that does not mean they were not genuine grievances but sometimes we can simply explain to people what the situation is. Of the cases that we looked at we simply gave advice in about 60 per cent of the cases. We refused to look at just seven per cent but that will be because they really were not areas within our competence. Then we break down what we did in other ways in our annual report. The split is usually about that, advice given in two thirds of the cases.
42. Was there any one body that you felt compelled to go and talk to and say "Now there is obviously a fundamental problem ..." just pluck figures out of the air "... 600 people have come to us to complain about you"? Have you been in touch with an organisation to say "Look, come on, you have got to improve"?
(Mrs France) We are in touch with organisations all the time.
43. Is there one that you think
(Mrs France) My staff are in constant dialogue with a range of data controllers. The difficulty I suppose in picking companies is it depends on the nature of their business. Year after year since 1987 I have to tell you that credit reference agencies would come top of the list but that is because they are dealing with credit information coming from all lenders. There are only three credit reference agencies in the United Kingdom holding that information. I would want to say to you there that we have had a very, very constructive year in our discussions with the credit industry, with the credit reference agencies and lenders, in changing their approach to how they keep information. That has been something that I really think we should trumpet because it is an example of our working with industry and achieving a change in process which they have put in place and we have not had to go to the stage of full enforcement. This is an issue you will be aware of I am sure. It is an issue that takes us back a very long time when in my predecessor's day credit reference information was filed by name or address and where he took enforcement action. So since the early 1990s credit reference agencies have filed by same name, same address but not by address only. Even that was causing problems, it was not what my predecessor had looked for and the problems have got worse and worse because we get more and more complaints, particularly when you have adult children living at home, where there is an assumption of a financial connection but no financial connection exists. Now to get them to change their procedures was going to be a massive investment for them. They have had to change the way they approach the filing of information. But, taking it constructively with them, giving a reasonable amount of time for change, engaging parts of the industry and working with them, they have now agreed that filing will be, to put it at its simplest, it is more complicated than this, only bringing together names where there is evidence of a financial connection. They are working towards that. I think that is a very good example of where we have always had most of our complaints, if I can call it that, but where industry has now responded and responded positively to the need to recognise the environment in which they operate.
Mr Heyes
44. The data protection issue, you said in your annual report that a major project for you has been the Employment Practices, Data Protection Code. The Committee has been lobbied by the Chartered Institute of Personnel and Development, the CIPD, an authoritative and respected organisation. You say in your annual report that your purpose in putting the code of practice together was to seek to provide the clear practical advice for which there is clearly a need. The CIPD, if I try to capture their thoughts in a sentence, say "I wonder whether the Commissioner has considered whether or not the code is a proportionate response to the issue it is designed to address". That has a feel of another organisation which, in Mr Smith's words, think that you may have gone over the top. Why have you thought it necessary to go over the top?
(Mrs France) We have thought very carefully about whether it is a proportionate response. I have to say I am surprised the CIPD have come to you because I had understood that the CIPDI do not know when they lobbied you...?
45. I can tell you, 3 July.
(Mrs France) They had been constructively involved in our restructuring of the advice and I had hoped we had met any concerns that they had expressed. Indeed, we have been having very positive feedback from a number of lawyers and those involved within large corporations with compliance issues on those parts of the code we have now published on our website. Let me start from the beginning very briefly.
Chairman: It will have to be very brief. We are going to be interrupted shortly by some bells. We had hoped to finish before the bells but we may have to go through the bells. There will be two lots of bells.
46. Can I try to help Chairman. I am particularly interested really in how you make the decisions as an organisation between the need to be thorough and comprehensive and fall into a trap of being over-prescriptive, that is the purpose of my question.
(Mrs France) We had for the first time in the1998 Act the ability to create codes of practice ourselves rather than agree other people's codes of practice. The first one we issued was on CCTV. The reason we looked at the employment code next was because we were getting very, very many questions from human resources departments, human resources staff, managers of companies asking us what the Data Protection Act meant for them. Instead of dealing with those piecemeal we decided the easiest thing for them and for us was to set it all down in a code of practice.
47. Two hundred pages.
(Mrs France) It has been a mammoth task because employment law and data protection law and where they interface is a complex issue. Now it is, I think, somewhat shooting the messenger to accuse us of making things over-complex. What we are trying to do is explain what is a complex set of law. The number of pages you have just mentioned, I think you will find our approach now is rather different from when we started out. We have had a lot of people asking for more. We have had a lot of people write in and say "You have not covered this" or "You have not covered that" and "Why can you not say more about this" and we have others saying there is too much and it is too complex. What we have tried to do is set out some guidance with a set of checklists at the back. We have changed the structure completely. We have sent it out to technical writers to try and make it more accessible and we are inviting the Small Businesses Council to write for us a version for small businesses so it is simpler. This is not meant for small businesses, it is meant for organisations which have a human resources department and have in-house compliance advice. Clearly we have to get the balance right. I would like people to take time to look at how useful this turns out to be. The response we are getting currently from practitioners now that we have got several parts on our websitewe have actually got two parts out there, two parts of a four part code available on our website for them to look atthe feedback that we are getting is that the checklists are particularly helpful. Now although the checklist adds to the number of pages in terms of density of script they are meant to be easy to use. It is much easier to navigate than our initial drafts. We have been delighted with the response from people like CIPD and we have tried to take account of their comments. I hope they agree that it is a far better document than the document we set out with. All I can say is that as a regulator I will be obliged to look at allegations of breach of the data protection law in relation to employment issues. Employment issues are ones which are going to come up time and time again. Trades unions are very interested in employee rights. Is it not better for me as a regulator to set out, in anticipation of those, my interpretation of the Data Protection Act as it interfaces with employment law rather than to announce what my interpretation of the high principles set out in the Data Protection Act are at the point at which I am faced with a particular decision to take? My intention is to be a modern regulator and to be out there giving you my interpretation of high level law in advance of decisions. We will listen to criticism. This is not set in concrete because it is guidance. It is there on our website. It will clearly be amended in the light of individual cases. At the end of the day it is up to individuals to decide how far they want to use this guidance within their organisation. They have three choices. They can pay heed to the guidance. They can lobby for changes in the law. Thirdly they can decide that this is simply the Commissioner's guidance and interpretation and take a risk management approach to how much notice they want to take of it, but not then cry should I have to take enforcement action in the light for example, of an individual case.
48. There is not a lot of mileage in pursuing this specific case. The CIPD do say their ". . . employers will regard compliance with the code as necessary to follow the law . . . the Commissioner's aim is to promote good practice, rather than simply legal compliance . . . It would be of interest to know whether or not she has considered issuing a guide on employee data, rather than code of practice"?
(Mrs France) We have considered it. We have looked at the whole remit of our responsibilities. We are satisfied that we have not added any gold plating in the code. It is our view that indeed people need to comply with the code to comply with the law. If they want to lobby for a change in the law that is a different matter.
49. Is this then an example, which I recognise happens, of business organisations, employers, trying to squirm out of necessary controls by pleading they are over-prescriptive and lobbying about wishing to be free from regulations? Is there an example of that here?
(Mrs France) I repeat, I am confident, and unless anybody would like to show me examples where I am wrong, that I am not adding to the regulatory burden, I am not adding to the law, I am explaining it. It is not for me to make or change the law. I am, however, under a statutory duty to raise awareness of the legal issues in this area and to enforce if breaches are brought to my attention. If what is actually being said is that the regulatory framework is burdensome then the proper place for lobbying is Parliament and not my office.
50. Thank you for that. I think that brings us probably to the end. All I would ask you, we are not going to see you again, I wonder if you have any parting shot for Parliament as you finish this period?
(Mrs France) I think the interest of this Committee in our work has been helpful. Helpful to us and I hope helpful in making what we do more visible and transparent, and I welcome that. I am sure my successor would want to keep a relationship with this Committee which I would see as one which is developing at the moment. I think that this whole area of work is one that has become more centre stage and will become even more centre stage because information in the hands not just of Government but of businesses everywhere is one of the key assets and is increasingly one which will create difficult situations and will perhaps sometimes be one where we are bound to point out to people what their obligations are in a way which they might not feel is comfortable and where it is valuable to have the opportunity to explain why we have done it. So your continuing interest will be welcome.
51. Thank you for that. You have been a most distinguished Data Protection Commissioner and a most distinguished Information Commissioner. I think we are all in your debt for that. I think there is genuine regretas I said at the beginningthat you are not going to be seeing the new statutory information regime into operation. I think we would feel more confident and secure if you were going to be. We thank you for the past and we wish you well for the future.
(Mrs France) Thank you. I would just like to say that I am confident that there is a strong team in the office who will carry things forward. I am sure once we know who my successor is you will have confidence in that situation.
Mr Heyes: Probably called Smith.
Chairman: Thank you very much.


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Rooms for Hire
The rooms within the Church are available for hire for public and private events. Prices quoted are for private use; commercial rates on application. An electric piano is available - please ask for details. Click on the small pictures for a larger version.
Size 10m x 25m approx., small stage, direct access to toilets, up to 150 folding chairs and folding tables available. A sound system (including loop system) and separate lighting system (spotlights and disco lights) are available on request. Ideal for children's parties and sports/fitness activities.
Price £25 per hour for hall / £25 for use of sound system with any booking / £10 for use of lighting system with any booking
Size 5m x 10m approx., projection screen, blackboard, flexible layout of tables and chairs. Ideal for meetings of up to 20 people.
Price £10 per hour
Size 5m x 4m approx. Includes a range of appliances - gas cooker with oven, dishwasher, fridge/freezer, microwave, kettle, water boiler.
Price £7.50 per booking for "party access" (no gas or electric appliances to be used) / £10 per hour for use of all appliances
Size 3m x 3m approx. Ideal for meetings of up to 10 people.
Price £8 per hour
To make an enquiry about room availability and to make a provisional booking, please contact the Room Letting Convener - Jacqui Stirton on (01382) 505566 / firstname.lastname@example.com To confirm a booking, please complete an Accommodation Form and pass it to the Room Letting Convener.

subset: commoncrawl


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Weight Loss and Slow Carb IV
Jan 19
Well, the graph today is looking great! Probably mostly due to water loss during my "Esther Fast" which ended at midnight. Over the next 18 days I will continue to fast on an intermittent basis (fasting Sunday, Monday, Wednesday, Friday) to complete the prayer challenge. The polyphasic sleep pattern isn't really working for me yet, but I'm still pushing through to get to a place of comfort. I need to sit down today and work out the actual sleep rhythm for optimum rest. Currently I'm in bed at 9:00, I sleep until 11:30 or so, get up for 2 hours of prayer, back to bed by 2:30, and up around 6:30-7:00. Feel a little "thick headed" but I'm coping. I think I need to re-adjust my times for optimal results. I'll keep you posted! 🙂
Anyway, here's the graph:
Get your own graph at skinnyr
Regarding the slow carb – the weight has come off more slowly than anticipated, but as I re-researched I realized that I'm not getting enough protein, early enough, in the morning. I'm up early but don't usually get to breakfast until about 7:30. According to Tim Ferriss, I need to eat 25g of protein within the first 30 minutes of getting up, so today I started with a protein shake. Once I'm finished posting this blog, I'll have my usual breakfast. It will be interesting to see how this changes my results.
Well, that's all for today!
Happy Walking!
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'Pines' premiere makes for busy night in Schenectady
Movie premiere excitement in Schenectady wasn't limited to the short stretch of red carpet laid down in Bow Tie Cinemas on Thursday night
Just a few doors down, Aperitivo Bistro was debuting its own "The Place Beyond the Pines" excitement with a specialty drink, according to co-owner Peter Blackman. People were drinking "Beyond the Pines," a cocktail that features gin.
"We thought we would make a big deal of it," Blackman said of rolling out the summer cocktail to coincide with the movie premiere.
More 'Pines'
To follow tweets from Gazette staff, including reports, photos and videos, click here.
You can share your own tweets by mentioning us or using the #PinesPremiere in your tweets, which we will retweet. Feel free to post your photos on our Facebook page, too, and we'll highlight them.
And remember, The Gazette is planning to give away 10 copies of the mock printed edition of The Daily Gazette that was featured in the movie to readers who share the best pictures with The Daily Gazette's Facebook page or via Twitter at #PinesPremiere.
Whether it's a shot from the filming in 2011 or a picture grabbed from the post-premiere party at Johnny's, share it with us.
The restaurant's connection with the movie goes beyond the drink, though, as he noted that stars from the film, like Ryan Gosling, Eva Mendes and Bradley Cooper, ate there during filming. They and the crew apparently liked it, too, Blackman said.
"We would see them a couple times a week," he said.
Aperitivo was open late to handle the hundreds of people who rolled out of the theater after the movie.
For an exclusive group of 200 people, the after-movie event was a special party across the street at Johnny's. Restaurant co-owner Bob Mallozzi wasn't saying much about the private party, which was scheduled to begin right after the movie ended and run until 1 a.m. This was a high-profile exposure for the new restaurant, which has been operating for less than a month.
"We're extremely honored that [Focus Features and Bow Tie Cinema] chose Johnny's, and we're extremely honored to be part of this Schenectady experience," Mallozzi said.
Aperitivo's Blackman said the premiere was a big night for Schenectady since it would likely attract people from all over the Capital Region and expose the city's downtown to a whole new crowd. He added that Schenectady businesses were putting their best foot forward for the special night.
"It's not usual for the Capital Region to have a movie premiere," he said.
Immediately after the movie premiere started, there was a crowd coming into Bombers on State Street. There was a lot of talk about returning to the theater later that night for the rumored appearance of Bradley Cooper, who was suspected to be driving to the city from Boston.
The night was also special because it featured two performance of Cathy Rigby's "Peter Pan" at Proctors. The matinee and late showing at Proctors, plus the Pines premiere, said Blackman, meant a steady flow of customers with all different plans on Thursday night.


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Leverstock Green 1 St Margetsbury 5
Leverstock Green finished their season with a disappointing defeat at home to St Margaretsbury.
The visitors started the game in lively fashion and had already had a couple of chances before taking the lead in the third minute through Lee Roberts.
Leverstock's first effort at goal came in the 17th minute when Tobi Akin struck a good effort from the edge of the box which hit the post.
And Levy pulled the scores level in the 28th minute from the penalty spot.
Marvin Tabi's fierce effort at goal struck the hand of defender Steve Barker, and the referee had no hesitation in pointing to the spot. Top scorer Akin made no mistake to notch his 20th goal of the season.
However, the referee was pointing to the spot again at the other end 13 minutes later as Chris Cutler was penalised, allowing Anthony Anstead to tuck away the penalty and put St Margaretsbury back in front at 2-1.
The game was still well-poised at half time, but Levy lost midfield fulcrum Adrian Colorado to injury just before the break and his side made a slow start to the second half.
Just three minutes after the interval, Josh Lillis netted from close range to score his side's 100th league goal of the season.
That was the end of the Levy resistance, and two further goals from Davy Edmee wrapped up the win for the visitors.


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This salad dressing, along with the toasted walnuts and Ramen noodles, rocks! My mom makes a dressing like this for our Holiday get-togethers and I tend to forget about it over the year. I won't forget about this baby again!
For the dressing:1/2 cup vegetable oil
1/4 cup sugar
3 tablespoons white wine vinegar
4 1/2 teaspoons soy sauce
Salt and pepper to taste
For the crunch:
2 tablespoons butter
1/2-1 cup walnuts
1 package oriental Ramen noodles (I must mention these things only cost 22 cents)
In a medium size skillet, melt half the butter and toast the Ramen noodles. Once they turn a darker brown (don't burn them) add the seasoning packet. Once golden in color, rest them on a paper towel. Add the rest of the butter and toast the walnuts for a few minutes or until dark gold in color.
For the salad:
Romaine lettuce
Fresh broccoli
Red bell pepper
Red onion
Cherry tomatoes
Strawberry slices
Add the lettuce and the veggies, then the walnuts and Ramen noodles. Last but not least, give the dressing a big shake and then pour it on. Give it a good toss and dig in!


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By Innes McCartney
The expedition, led by 'submarine-hunter' Innes McCartney, will be the first attempt by technical divers to survey and identify the wrecks of German U-Boats scuttled by the Allies after WWII in the waters north of Ireland.
There are 54 submarines which lie within the depth reachable using today's technical diving equipment and methods, and it is believed that the wrecks of these vessels, sunk during Operation Deadlight, could in future be seen as one of the world's greatest naval heritage sites and compared to such locations as Bikini Atoll, Scapa Flow and Truk Lagoon.
Part 1
A Bit Of History
At the end of 1945 Britain had in its possession 110 German U-boats, based at Loch Ryan, Scotland and Lisahally, Northern Ireland. The British Government made a decision that all these boats were to be sunk by various means in deep water. Some say this was meant to be a terrible retribution for the damage that U-boats had done to the Allies. Orders issued on 14th November 1945 outlined the fate of these vessels and "Operation Deadlight" began.
Those vessels that were to be scuttled had explosive charges placed in the forward and aft torpedo tubes and various hatches. These were to be detonated by use of a physically set fuse, or in the event that men were unable to board, an electrical fuse, detonated by the towing ship. The other U-boats where to be sunk by aircraft, gunfire, torpedoes and the then top-secret "Squid" ship-to-ship missile.
Operation Deadlight's D-Day was to be 25th November 1945 and would continue until 12th February 1946. The U-boats were to be towed to an area approximately 120 miles northwest of Ireland known as Position ZZ. Due to the onset of winter gales and unsuitable towing vessels, 57 U-boats never made it to Position ZZ.
U3514 (Type VIIc) was the last U-boat to be sunk in Operation Deadlight. On the morning of Tuesday 12th February HMS Loch Arkaig sent five 4'' shells towards U-514. Only one shell hit the casting forward of the conning tower. She then strafed the U-3514 with close range weapons, but the U-3514 was still afloat. HMS Loch Arkaig then fired six "Shark projectiles". Two hit amidships and one ricocheted off the conning tower without exploding. The commander of HMS Arkaig ordered the ship to break away and prepare for another run using "Squid" missiles. Whist the Arkaig was getting into a reasonable attacking position, the bows of U-3514 began to sink. She hung there vertically for a moment, then slid underwater. HMS Arkaig finally loss contact with the U-boat at 600 feet. U-3514 had, in her last action, demonstrated many of the reasons why the Allies had found it so difficult to deal with the U-boat menace during WWII.
About The Expedition
Among the U-boats sunk during Operation Deadlight are some of the most famous U-boats of the Second World War which were captained by some of the greatest commanders. The 2001 Expedition, which will take place in the last two weeks of July based aboard MV Salutay, aims to capture for posterity these historic wrecks using underwater photography and video.
The expedition is focusing on filming two of the revolutionary Type XXI 'electro' U-boats. This class has been called the world's first true submarine because it was designed to operate entirely underwater. Earlier U-boat designs should perhaps be more correctly described as 'submersibles', as they were reliant on frequent returns to the surface for battery charging and ventilation. The Type XXI was introduced into service in 1945, but many unresolved technical problems prevented it from reaching its true potential.
U-2511, captained by Adelbert Schnee, was the only Type XXI U-boat to sail against the Allies. This and Horst von Schroter's U-2506, another Type XXI, will be key targets for the expedition.
The successful U-155, a Type IXC which was captained between 1941 and 1944 by Adolf Piening, is another target. Piening was responsible for the sinking of 26 ships including the British carrier 'Avenger'. Jurgen Oesten's cargo U-boat U-861, and Heinrich Schroteler's U-1023 are also to be filmed. U-1023 was the last German U-boat to sink an Allied warship: Schroteler torpedoed the British minesweeper NYMS 382, before surrendering at Portland six days later.
These vessels represent the wide ranging activities of U-boats in World War Two and each has an interesting service history.
The expedition boat MV Salutay is a 59 foot motor yacht, well equipped for technical diving. She carries two compressors, a Haskel booster pump and the necessary supplies of oxygen and helium, and is fitted with Vosper stabilisers to help cope with choppy conditions.
The diving depths will be in the 75m range and diving will be done using both open-circuit and closed-circuit trimix.
Based aboard the Salutay, the team hope to be able to range widely across the Operation Deadlight area. The seas north of Malin Head have little or no tide so the dive team will be able to use a ROV to look at three or four submarines each day, before they deciding on which one they wish to dive.
The Ministry of Defense and the UK Hydrographics Office have been fully informed of the expedition's plans and objectives.
Part 2Expedition Diary
This is the personal diary of Innes McCartney which recounts the day to day events of the expedition.
Day One: 14th July 2001
Target: Unidentified submarine wreck.
Depth: 60 metres
Weather and sea conditions: Sunny, wind 3-4 NW
Underwater visibility: 20-30m
Diving report:
This wreck lies 1.5 miles from the reported sinking position of U218, which foundered under tow on 4/12/45 while on her way to be expended as an aircraft target. We therefore expected that this wreck would turn out to be this rare VIID U-boat.
At a depth of 60 metres in huge visibility and much ambient light, the wreck of U218 was found. The superb conditions made for high quality video and stills images of the wreck. She was an absolutely incredible sight.
U218 lies over on a 45-degree list to port. Apart from minor damage to bow and stern, this wreck is completely intact. The 5-chute mine section behind the conning tower made this wreck easily indefinable. She is the only VIID in the world that has been dived so far, making her a rare treat for the diving team, and a fantastic way to begin the expedition.
The underwater conditions at the moment mean that we are expecting several other first-class submarine dives in the next few days.
Underwater images of all the wrecks will be made available at the end of the expedition.
On the way from Portpatrick to the wreck, MV Salutay passed over the wreck of U1014, which was sunk in February 1945. As a war-grave, she is a salutary reminder of the realities of the U-boat war. The diving team took time to reflect upon the huge sacrifices made by the Ubootwaffe in WW2.
Day Two: 15th July 2001
Target: U2511 - Type XXI
Depth: 69 metres
Weather and sea conditions: Sunny, wind 3 NW
Underwater visibility: 20-30m
Diving report:
The wreck of U2511 was located and dived by our skipper Al Wright (see Meet the Team) in 1999. Since then, it had not been re-visited until this month. Today the Operation Deadlight Expedition dived the wreck and photographed and videoed it extensively.
Diving at midday in bright sunshine, the wreck was visible from 45 metres on descent!! It was possible to see the entire submarine lying on a white sand bottom, clearly recognisable as Adalbert Schnee's U2511.
A tour of this wreck reveals that it lies on its port side and is essentially completely intact. The point section of the bows has gone and the divers could see all six of the torpedo tubes pointing forward. Continuing along the hull, the torpedo-loading hatch was open. Passing that, the massive conning tower, which dominates the wreck, came into view. The forward flak turret is still in place, looking absolutely spectacular, as did the slightly raised sky periscope. The conning tower hatch was open, as was the hatch that led to the stern flak turret. This has fallen off the tower and lies upside down on the seabed. Aft of the tower, the wreck is complete, all the way to the stern, where the hydroplanes and single rudder are still in position.
U2511 was sunk by gunfire, after her towing cable broke. There is a sizable blast hole in her starboard side, alongside the tower. Swimming into this hole reveals a mass of cabling and many batteries all along the keel section of the wreck. Looking forward, the divers could see the open bulkhead door leading to the forward compartment.
This was one of the most spectacular U-boat dives I have ever done (I have dived more than 40). It is a rare sight indeed to have the visibility to see an entire submarine in view at 69 metres. This was made all the more significant by the fact that the wreck was U2511, the only Type XXI to approach an allied navy convoy.
U2511 is perhaps the most historically important U-boat wreck of the Deadlight fleet. She has now been photographed and filmed for posterity. A spectacular, if salutary reminder of the massive jump in submarine design and technology made during World War Two.
Tomorrow we hope to be able to locate U2506, the other diveable Type XXI in these waters…. We'll keep you all posted.
When one looks at photos of U2511 in Norway, or at Deadlight, she appears to be a light grey, even white, when the other Type XXIs around her seem to be painted in the standard navy-issue grey. My friend, Jak Mallman-Showell explained that, Adi Schnee had taken a ride in an aircraft over his base in Norway and seen the way that the XXIs stood out from above. He then decided to re-paint U2511 with a brighter colour to afford it a higher degree of camouflage.
As with any of the U-boats that I have dived, I welcome correspondence with crewmembers and their families.
Day Three: 16th July 2001
Target: Unknown submarine wreck. Never dived previously.
Depth: 69 metres
Weather and sea conditions: Sunny, wind 2 SE
Underwater visibility: 20m
Diving report:
Today we had hoped that the position we were to dive would turn out to be U2506. However, what we found has turned out to be a bit of a mystery. The diving team were looking at a position slightly to the north of a cluster of submarines sunk during Operation Deadlight.
At 69 metres depth, the diving team located the wreck of a Type VIIC U-boat. It is certain that this submarine is NOT one of the Deadlight fleet. According to Dr Niestle, two U-boats were lost in these waters at the end of World War Two. It seems we have found one of them, but which one?
The evidence pointing to this being a war loss is as follows:
a) The attack periscope and schnorchel have been bent/broken off at about the height of the conning tower. The base of the schnorchel stands upright, still located in its collar on the conning tower. The attack periscope is bend right over, so that the lens is buried in the seabed.
b) There are closed ready-use ammunition lockers around the collapsed wintergarden area. Deadlight U-boats were stripped of all ammunition.
c) All the hatches on the wreck are closed - suggesting it was schnorcheling at the time of sinking.
d) There are no signs of damage to the pressure hull - from gunfire/squid/air etc, as could be expected if this had been sunk during Deadlight.
e) The position does not tally with any Type VIICs sunk during Operation Deadlight.
From the damage to the wreck, it seems likely that this submarine was in a collision whist schnorchelling, which resulted in the boat flooding. It is possible that we will never know how this happened.
Other observations made on the wreck included the fact that it had not been fitted with life raft canisters on the bows and that it seemed to have been constructed to carry a deck-gun, as the mounting could be seen forward of the conning tower. There was no evidence of an air radar search receiver on the head of the schnorchel.
Dr. Niestle's reappraisal of World War Two U-boat losses places both U482 and U296 tentatively in these waters. Both of these U-boats were schnorchel-equipped VIICs (U296 was a VIIC/41), launched on the same day in 1943. It is quite likely that we have found one of these two U-boats. However, as with all unidentified U-boat wrecks, the above can only be considered speculation. Two other U-boats were sunk around this area: U1014 (which has been found - see report for day one) and U1003. The sinking circumstances for U1003 don't seem to fit the condition of the wreck we have located, because. there were survivors from U1003, meaning that the hatches could be expected to be open. Moreover the sinking of U1003 occurred several miles to the east of this wreck.
For researchers and others interested in looking into this mystery, the wreck in question was situated at approximately 55 38N 07 26W.
Diving on a wreck that seems to be a war-grave was a sombre surprise for the expedition divers. Today we remember the lost from both sides of the Battle of the Atlantic.
Planning ahead, we are hoping to look for U155 (Adolph Peining's boat) and continue our search for U2506.
Part 3Day Four: 17th July 2001
Target: U861 - Type IXD2. Unable to dive due to bad weather.
Depth: 43 metres
Weather and sea conditions: Sunny, wind 7 E
Underwater visibility: unknown
Diving report:
Easterly gales prevented us from attempting to reach our planned targets for today. Instead, we planned to dive the well-known wreck of U861, which was sunk during Operation Deadlight. Even though this site is protected by Inishtrahull island, the sea conditions were too dangerous for diving.
Instead we satisfied ourselves by locating the wreck on sounder and planning to dive this wreck at some time later in the expedition.
We will be running into Portrush tonight. In the event that the weather does not blow through overnight, allowing us to get back on track, we will be well placed to attempt either U861 or the war-grave U1014 tomorrow.
We have reviewed the video footage from the dives conducted so far and can confirm that it includes some of the finest footage of sunken submarines we have ever seen!!!
Media interest in Ireland and Scotland has been increasing steadily. Innes is conducting radio and newspaper interviews daily as the expedition continues to grab the attention of the public.
Plans are now afoot to find the best possible means of presenting a film of the expedition, showing the spectacular images so far attained.
Day Five: 18th July 2001
Target: No target due to gales.
Weather and sea conditions: Sunny, wind 7 E
Diving report:
Gales prevented us leaving Portrush harbour for most of the day.
We intend to move to Ballycastle tonight. In the event that the winds continue as they are, we will be able to dive on the wreck of U33, which is in the entrance to the Clyde. Although not a Deadlight wreck, she has an interesting history in the tale of the cracking of Enigma. Also, she is a rare Type VIIA, equipped with the 88mm deck-gun.
If the winds drop, we will be able also to reach the site of U861.
Weather intervenes on all diving expeditions.
It is time to be philosophical and wait for the weather to change.
Day Five: 18th July 2001 - Supplemental
Due to bad weather, the Operation Deadlight Expedition is currently in port.
In order to give the viewer some information to read today, I would like to take this opportunity to list some of the U-boat wrecks I have located and filmed over the last few years. Links to where you can read more about the wrecks and see some underwater images are included.
UC65 - LaLa Lafrenz' U-boat sunk by a British submarine. Wreck in two halves.
UC51 - Minelayer lost of Start Point in a British minefield. Mine chutes still full of 'eggs'.
UB81 - Rhienhold Saltzwedel's submarine, lost in tragic circumstances off the Isle of Wight.
UB72 - Sunk by a British submarine in Mid-Channel - fantastic dive.
UB37 - Sunk by a British Q-ship - small UBII-Class in excellent condition.
UB74 - Sunk by Yacht 'Lorna' - one survivor killed by exploding depth charges.
UB130 - Sunk on way to breakers yard.
Unidentified U-cruiser - located off Brixham.
Underwater images of some of these wrecks can be seen at www.periscopepublishing.com/WW1_U-boats.htm
U33 - VIIA - Enigma rotors came into allied hands as a result of the sinking.
U480 - An Alberich U-boat identified 200 miles from its official sinking position.
U678 - Sunk by a Canadian escort group off Brighton.
U671 - Sunk off Brighton.
U1195 - Sunk off the Isle of Wight after sinking the liner 'Cuba'.
U772 - Sunk off Portland.
U1191 - Sunk in Mid-Channel.
U212 - Lost off the Sussex coast U269 - Macintyre's last kill - sunk Mid-Channel.
U413 - Gustav Poel's boat, lost off Brighton.
Unidentified VIIC - NE of Cherbourg - We believe that this could be U767, however this is still far from certain.
U741 - lost in the Baie de Seine.
Unidentified VIIC - Baie de Seine - NOT U390 or U741 - possibly U441 or U988.
U260 - Mined off southern Ireland - images available at www.uboat.net/gallery/diving/index.html.
Underwater images of many of these wrecks can be seen at www.periscopepublishing.com/WW2_U-boats.htm.
I hope you enjoy the images. I am always interested in corresponding with families who have an interest in any of the U-boats mentioned, or sunk around the British Isles.
Day Six: 19th July 2001
Target: U1014 VIIC/41
Depth: 69 metres
Weather and sea conditions: Sunny, wind 2-3 E
Underwater visibility: 20 metres
Diving report:
Gales prevented us leaving Portrush harbour for most of the day. However, the weather dramatically improved in the afternoon, so the team was able to make a dive on the wreck of U1014, which was sunk in 1945 by an escort group off Portrush.
This submarine wreck is extremely badly damaged. It was hit by depth charges in three places, reducing the submarine to a useless hulk. It is clear that the crew mercifully must have died quickly.
The blast holes are in the forward torpedo room, the area around the captains bunk/sound/radio rooms and aft of the winter garden. The damage amidships is so bad, that little of the conning tower remains. The hydraulic elevator for the schnorchel is now sitting where the captain would have slept. Only the 'Atlantic' bow and the stern remain undamaged.
This wreck is heavily populated with lobsters and conger eels.
Yesterday afternoon was spent in the company of BBC Television who interviewed the divers and prepared to release a news story for 5-6pm tonight. The story lasted 2.5 minutes and showed the footage of U2511 along with the background to the expedition.
Tomorrow and Saturday are changeover days when some divers leave the expedition and others join.
Hopefully, weather dependent, the next expedition diary will appear on Sunday. We intend to head back to the area where we expect to find U155 and possibly U2506.
Many thanks to my friend Axel Niestle for his analysis of the dive we conducted on Day 3. It is heartening to know that our discoveries can lead to the identification of an unknown submarine loss. This has happened several times over the years and is the greatest reward we as divers can have from our endeavours.
Part 4
Day Seven: 22nd July 2001
Target: U369 VIIC
Weather and sea conditions: Sunny, wind 2-3S/w
Depth: 67 metres
Underwater visibility: 20 metres
Diving report:
In excellent sunny conditions we travelled back to the Deadlight area and arrived in time to make a dive on an undived U-boat. We believed that this could be either U778 or U369.
The wreck itself is the most intact U-boat any of us have ever seen!! The conning tower retains its cladding, and all of its bridge equipment!! Really an incredible sight to see!! Again, the video images are stunning, even when considering that the divers encountered strong currents on this dive.
As for identity, the wreck has a mounting for a 88mm deck-gun, it is schnorchel-equipped, with the head having both 'bali' and the sorbothane coating. There were no life raft canisters on the bow. From this information, we deduce that this is probably the wreck of the school boat U369.
A school boat is a rare dive in British waters. It was especially pleasing to find it so intact.
It looks as if we are in for a few days good weather, so look out for some exciting reports in the next few days.
Day Eight: 23rd July 2001
Target: U637 VIIC
Weather and sea conditions: Overcast, wind 5-6 SW
Depth: 70 metres
Underwater visibility: 25 metres
Diving report:
The position we dived today was likely to be U637 or U155 (which we were hoping it would be).
The diving conditions were marginal, with wind and building seas. Only 3 divers made the choice to go in. However, as with the other submarine wrecks in these waters, they were treated to a spectacular dive.
The wreck was that of a VIIC lying on its port side. The visibility was so good, the divers could see the wreck from 45 metres while descending!! Again the video footage of the wreck is simply fantastic!
A brief description of the wreckage - The bow tubes have been dragged off to one side, with all four still held together in the bow bracket. The bow end of the pressure hull marked the beginning of the main wreck. Galley hatch has fallen open, she was fitted with a schnorchel with anti-radar covering and air radar warning dipole. The conning tower hatch was shut, while the bow torpedo-loading hatch has also fallen open, revealing a pile of Kriegsmarine china in the torpedo room, which was a surprise, since we believe that allied souvenir-hunters had stripped most of these before scuttling. The bow tube has also been torn away from the wreck.
Generally this wreck was in poor condition.
Interestingly, this is the first time I have seen the racking used to hold the ready-use ammunition for the 88mm deck -gun.
Our hunt for U155 continues..
We expect the weather to get better over the next couple of days, so we continue to explore the wrecks of Operation Deadlight - submarine diving heaven.
Day Nine: 24th July 2001
Target: U155 IXC
Weather and sea conditions: Sunny, wind 4-5W
Depth: 73 metres
Underwater visibility: 25 metres
Diving report:
The location of this most famous of U-boats was one of the key expedition targets, and today, we believe we achieved it. To be the first to dive on Adolf Piening's U-boat was a great treat for the team and a just reward for the efforts all of us have put in, especially to keep diving during this period of marginal weather.
In stunning visibility at 73 metres the unmistakable giant shape of the Type IXC U-boat was found sitting bolt upright on the seabed. Her forward hydroplanes and torpedo tubes have fallen off to one side, revealing the bow end of her pressure hull, apart from this damage, the wreck was entirely intact. This included all of the outer cladding attached to the pressure hull, which gave this wreck the 'beamy' shape of the Type IX.
Some observations about the wreck include the schnorchel on the starboard side of the foredeck (with round dipole), the heavily reinforced support for the wintergarden still in place (like the one on U869), conning tower hatch open (allowing the divers to see clear into the control room via the opened lower hatch), aft dingy recess on the deck was empty, both external torpedo doors were shut. All of the external torpedo containers have been removed.
There was no evidence of life raft canisters having been fitted to this U-boat.
This was undoubtedly one of the most impressive dives we have done during the course of the expedition. The video footage of this wreck is some of the most mind-blowing taken so far. Extensive stills photographs were also taken.
What of U2506? Well, we have dived every submarine wreck that has been found during admiralty surveys over the last 20 years, which lie within five miles of where she supposedly foundered. She will be here somewhere and the search continues. It is becoming apparent that the 1946 disposals have the least accurate sinking positions and that generally the Loch Ryan disposals are more accurate than the Lisahally ones, although in the long-run this may not turn out to be the case.
We may find U2506 tomorrow, when we examine a position, which like many others in these waters has no obvious identity.
Operation Deadlight Expedition Phase II will be running from 3rd to 18th May 2002. Any interested sponsors and divers should e-mail me as soon as possible. We are making history - the hard way - please support us.
Part 5
Day Ten: 25th July 2001
Target: U637 VIIC
Weather and sea conditions: Sunny, wind 2 SE
Depth: 70 metres
Underwater visibility: 25 metres
Diving report:
This wreck is definitely U637, NOT the one we dived on Day 8.
The wreck is a very intact VIIC, which under normal circumstances would be difficult to tell from any other VIICs sunk during Operation Deadlight. However, it had one feature, which makes it very special indeed - a ring-float schnorchel head. U637 was photographed with one prior to being disposed of.
All other features of this wreck, were as per normal late-war VIIC.
Life raft canisters on bows. As to the real identity of the one we dived on day 8 - we suggested it was U637, because of its proximity to the sinking position of this U-boat - we were wrong - Our Deadlight photo album proves this. So the nearest type VIIs are U281 and U 1010. The presence of the 88mm gun mounting suggests that U281 is a possibility. However, we are learning that the positional information from official reports of Operation Deadlight is far from accurate. In fact, much of it seems, by today's standards to be highly unreliable.
Much more work is required to guarantee the identities which we have tentatively given to some of the U-boats we have dived. The one we dived on Day 7 - is now thought to be U778, thanks to Axel Niestle's continued assistance.
An interesting day, with at least one mystery surrounding the identities of these submarine wrecks definitely cleared up. We will publish a final report on our findings when we have had a chance to confer in detail at the end of the expedition.
Operation Deadlight Expedition Phase II will be running from 3rd to 18th May 2002. Any interested sponsors and divers should e-mail me as soon as possible. We are making history - the hard way - please support us.
Day Eleven: 26th July 2001
Target: Unidentified VIIC
Weather and sea conditions: Overcast, wind 1 SE
Depth: 69 metres
Underwater visibility: 25 metres
Diving report:
Another submarine wreck in astonishing visibility!
This wreck is a late-war VIIC with schnorchel to fit with conning tower trunking, and life raft canisters on the bow. Otherwise, there was little to differentiate this wreck from several other Type VIIs lost in this area.
Possible identities include U778, U281 and U825. Certainly, until several other positions in this area have been filmed, categorical identification will be impossible. However, it is possible that by working with Dr Niestle, a solution may present itself.
Tomorrow is our last diving day. We will be looking at another submarine mark 2 miles west of where we were today. Hopefully this will help to sort out the riddle of which submarine wreck is which.
We will publish a final report on our findings when we have had a chance to confer in detail at the end of the expedition. This process will involve coming up with a list of targets for Phase II, which takes place in May 2002.
Operation Deadlight Expedition Phase II will be running from 3rd to 18th May 2002. Any interested sponsors and divers should e-mail me as soon as possible. We are making history - the hard way - please support us.
Day Twelve: 27th July 2001
Target: Unidentified VIIC
Weather and sea conditions: Sunny, wind 3-4 SW
Depth: 69 metres
Underwater visibility: 25 metres
Diving report:
Yet another submarine wreck in astonishing visibility!
This is another VIIC wreck. It clearly shows the signs of the gunfire that sunk her. There is a blast hole though the conning tower, but more impressively, the entire bows have been blasted away. The forward section of the wreck contains all four torpedo tubes intact and the forward hydroplanes. The break affords the opportunity for the divers to swim right into the wreck, and peer through the forward torpedo room doorway and see right into the control room.
The other fascinating feature about this wreck is that it is the second U-boat wreck we have located that has been fitted with the 'ring float' schnorchel head. It is great to have found two wrecks which have this very rare fitting.
The conning tower hatches were open, as was the galley hatch. There was no evidence of the wreck being fitted with life raft canisters. Again the visibility was superb and the video footage is of the finest quality.
This great dive concludes phase one of OPERATION DEADLIGHT EXPEDITIONS. A fuller report on our findings will be published in due course. We have learned much and still have much more to investigate. This includes making two extra-deep dives to film an example of the Type IID and the Type XXIII. Sadly U2506 and U541 have eluded us. We will need to employ side scanning sonar next year to locate these.
Operation Deadlight Expedition Phase II will be running from 3rd to 18th May 2002. Any interested sponsors and divers should e-mail me as soon as possible. We are making history - the hard way - please support us.


text:
Sausage And Eggs: Man Comes Home To Nekkid Stranger Cooking Breakfast In His Kitchen
Man Finds Clothless Stranger Cooking Breakfast In His Kitchen
A Canada man got an unwelcome surprise recently when he came home to a bare-bodied stranger cooking in his kitchen. While the two other roommates who live in the home were there at the time, they said they just assumed noise in the kitchen was one of the other roommates.
via Toronto Sun
Police are reminding residents to not leave open doors or windows unattended, unless they're looking to attract naked and hungry trespassers.
That's after an east Vancouver man found a disrobed stranger cooking eggs in his kitchen at suppertime on Monday.
"It's a humorous story because this guy didn't get violent or anything, and he was arrested and nothing was taken and nothing was damaged, but it's a great reminder for everyone," Vancouver police Const. Brian Montague said. "He even showered before making himself dinner."
Montague said two roommates were home at the time, but thought the household noises they heard were just the regular sounds of a shared house, until one of the men entered the kitchen to discover the stranger and called police.
The trespasser is a Burnaby, B.C., man of no fixed address who is well-known to police, Montague said, adding that drugs most likely played a role in the break-in. Investigators are recommending a charge of being unlawfully in a dwelling house.
Ohhhhh, Canadaaaaa.


text:
One of first questions most people ask as they start shopping for a home loan is how much money they can expect to get. No one wants to find a home that matches all their needs and desires only to find out that it's out of their price range. But the mortgage approval process can take some time and you don't want to wait until it's over to find out how much money you can get. That's why home loan pre-approval was invented.
What Pre-Approval Is
Home Loan Pre-approval can be used as both a noun and a verb. It's describes a process where potential lenders go over your financial information to determine how much they can lend you. Once this process is completed they will provide you with a form, also known as a pre-approval, that can be shown to home sellers as evidence that you can afford to make a particular offer.
These forms are generally only good for a limited period of time, just a few months, so once you get one you have to shop while you can before you have to go through the process again.
Home sales can be tricky because they don't just involve two parties exchanging money for goods, like most trades. In this case one party is offering their money and the money of a third party, the lender. As such, an unscrupulous buyer could offer just about any amount of money and the seller would have no clear idea whether or not they could really make good on the offer.
A home loan pre-approval helps to fix this problem by providing evidence that a buyer can present to prove that they can in fact offer the money they are promising, although the truth is a little more complicated than the concept.
What Lenders Look at During Pre-Approval
During this process, lenders will be looking at your finances to try and estimate how much money they can give you with minimum risk, so that means they'll need to find evidence of your cash flow and credit history. Some of the documents that a lender may ask for include:
- Tax returns
- Contact information for your place of work
- Printouts representing your bank accounts
- Credit score
- Records of outstanding debts
Whiles some lenders mays ask for only a few of these items, others may ask for even more. Keep in mind that the more documents they have the more accurate your number will be, so don't try and hide anything because it will come out during the approval process, even if it gets missed during pre-approval.
Lenders are looking for you to prove that you are the type of person who can be trusted with money. That means that you should do what you can to show that you have been faithful with the money you have been lent in the past, that you have a decent amount of money coming in as income and that you don't have too many outstanding debts that could get in the way of payments on a new loan.
The bottom line is that the better you look after the process is done the more money you will be offered.
What the Number You Get Means
An unfortunate misconception that some people have is that home loan pre-approval numbers are in some way binding or set in stone. The truth is that they are basically just estimates and lenders don't have to give you the money they pre-approve you for.
When some people find out the truth about home loan pre-approval they begin to wonder why you would want to go through the process if it doesn't produce anything solid. What's important to remember is that even if the number you are pre-approved for isn't the final amount you are offered it is still a better estimate then you will be able to come up with on your own.
What You Should Do After Pre-Approval
If you get pre-approved and you're happy with the number you get then it's time to start getting serious about shopping for homes and making offers. Before pre-approval you can really only guess what you can afford, once you get your estimate you can zero in on the homes that are within your budget and price range.
Always remember that home loan pre-approval is simply the step before approval. It is in no way binding and lenders can and will modify their offer. This can be a good or bad thing, but fortunately the outcome is within your hands to some extent.
If you work hard to improve your financial standing then your final approval will likely be higher than your pre-approval, but if you start letting your finances slip then you will get less than you'd hoped. No number is final until the deal is closed and you own your new home.
If you want to buy a home, you should seek out pre-approval. It really is as simple as that. You need to get an idea of how much money you can borrow and the best place to get an estimate from is the lenders who will hopefully give you the money when all is said and done.
Just stay realistic through the process and do what you can to improve your financial standing until you finally get approved and buy your new home.
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text:
|Jean-Loup Huret
|Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France. firstname.lastname@example.com
|Review on t(1;17)(p36;q21) SPOP/PRDM16 translocation in astrocytic tumor, with data on the genes involved.
|Nervous system: Central Nervous system::Astrocytic tumor
|Clinics and Pathology
|A t(1;17)(p36;q21) was found in a case of astrocytoma grade I-II, but no further data is available (Yoshihara et al 2015).
|Phenotype / cell stem origin
|Grade I astrocytomas are pilocytic astrocytoma and subependymal giant cell astrocytoma, the latter being the most common central nervous system neoplasm in tuberous sclerosis; they are slow growing tumors; they typically occur during the first two decades of life. Grade II astrocytomas are pilomyxoid astrocytoma occurring most often in infants and very young children, diffuse astrocytoma, seen at any age, but often between ages 30-40, and pleomorphic xanthoastrocytoma, typically developing in children and young adults.
|Genes involved and Proteins
|Gene Name
|PRDM16 (PR domain containing 16)
|Dna / Rna
|11 splice variants
|1276 amino acids and smaller proteins. Contains a N-term PR domain; 7 Zinc fingers, a proline-rich domain, and 3 Zinc fingers in the C-term. Binds DNA. Transcription activator; PRDM16 has an intrinsic histone methyltransferase activity. PRDM16 forms a transcriptional complex with CEBPB. PRDM16 plays a downstream regulatory role in mediating TGFB signaling (Bjork et al., 2010). PRDM16 induces brown fat determination and differentiation. PRDM16 is expressed selectively in the earliest stem and progenitor hematopoietic cells, and is required for the maintenance of the hematopoietic stem cell pool during development. PRDM16 is also required for survival, cell-cycle regulation and self-renewal in neural stem cells (Chuikov et al., 2010; Kajimura et al., 2010; Aguilo et al., 2011; Chi and Cohen, 2016).
|Gene Name
|SPOP (speckle type BTB/POZ protein)
|Dna / Rna
|24 splice variants
|374 amino acids SPOP comprises a N-term MATH domain (Meprin And TRAF Homology; substrate recognition and binding), a BTB/POZ domain (Bric-a-brac, Tramtrack and Broad complex/ Pox virus and Zinc finger; connects to the CUL3 - RBX1 (Cullin 3-RING box 1) scaffold protein), a 3-box domain (facilitating CUL3 binding and resembling to F-/SOCS-boxes) and a C-terminal nuclear localization sequence. SPOP is a E3 ubiquitin ligase adaptor protein that participates in the degradation of various substrates. AR (androgen receptor), DAXX, BMI1, BRMS1 and PDX1 are targets of SPOP. SPOP is critically involved in SETD2 (a tumor suppressor) stability. SPOP enables homology-directed DNA repair of double strand breaks, and mutant SPOP promotes genomic rearrangements within chromosomes. SPOP suppresses gastric tumorigenesis through inhibiting hedgehog/ GLI2 signaling pathway. SPOP is frequently mutated in prostate and endometrial cancers. TMPRSS2 - ERG fusions, frequently seen in prostate carcinoma, encode N-terminal-truncated ERG proteins that are resistant to the SPOP-mediated degradation. Decreased expression of SPOP is associated with poor prognosis in glioma. On the other hand, SPOP is highly expressed in clear cell renal cell carcinoma (Zhuang et al., 2009; Mani, 2014; Zeng et al., 2014; Karnes et al., 2015; Ding et al., 2015; Rider and Cramer, 2015).
|Prdm16 is a physiologic regulator of hematopoietic stem cells.
|Aguilo F, Avagyan S, Labar A, Sevilla A, Lee DF, Kumar P, Lemischka IR, Zhou BY, Snoeck HW.
|Blood. 2011 May 12;117(19):5057-66. doi: 10.1182/blood-2010-08-300145. Epub 2011 Feb 22.
|Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
|An J, Ren S, Murphy SJ, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling GC, Cheng L, Sukov WR, Karnes RJ, Vasmatzis G, Zhang Q, Zhang J, Cheville JC, Yan J, Sun Y, Huang H.
|Mol Cell. 2015 Sep 17;59(6):904-16. doi: 10.1016/j.molcel.2015.07.025. Epub 2015 Sep 3.
|Prdm16 is required for normal palatogenesis in mice.
|Bjork BC, Turbe-Doan A, Prysak M, Herron BJ, Beier DR.
|Hum Mol Genet. 2010 Mar 1;19(5):774-89. doi: 10.1093/hmg/ddp543. Epub 2009 Dec 11.
|The Multifaceted Roles of PRDM16: Adipose Biology and Beyond.
|Chi J, Cohen P.
|Trends Endocrinol Metab. 2016 Jan;27(1):11-23. doi: 10.1016/j.tem.2015.11.005. Epub 2015 Dec 11. Review.
|Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress.
|Chuikov S, Levi BP, Smith ML, Morrison SJ.
|Nat Cell Biol. 2010 Oct;12(10):999-1006. doi: 10.1038/ncb2101. Epub 2010 Sep 12.
|Decreased expression of the SPOP gene is associated with poor prognosis in glioma.
|Ding D, Song T, Jun W, Tan Z, Fang J.
|Int J Oncol. 2015 Jan;46(1):333-41. doi: 10.3892/ijo.2014.2729. Epub 2014 Oct 24.
|Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
|Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM.
|Nature. 2009 Aug 27;460(7259):1154-8. Epub 2009 Jul 29.
|The emerging role of speckle-type POZ protein (SPOP) in cancer development.
|Mani RS.
|Drug Discov Today. 2014 Sep;19(9):1498-502. doi: 10.1016/j.drudis.2014.07.009. Epub 2014 Jul 21. Review.
|SPOP the mutation.
|Rider L, Cramer SD.
|Elife. 2015 Oct 27;4. pii: e11760. doi: 10.7554/eLife.11760.
|The landscape and therapeutic relevance of cancer-associated transcript fusions.
|Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG.
|Oncogene. 2015 Sep 10;34(37):4845-54. doi: 10.1038/onc.2014.406. Epub 2014 Dec 15.
|SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer.
|Zeng C, Wang Y, Lu Q, Chen J, Zhang J, Liu T, Lv N, Luo S.
|J Exp Clin Cancer Res. 2014 Sep 11;33:75. doi: 10.1186/s13046-014-0075-8.
|Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
|Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, Miller DJ, Walden H, Duda DM, Seyedin SN, Hoggard T, Harper JW, White KP, Schulman BA.
|Mol Cell. 2009 Oct 9;36(1):39-50. doi: 10.1016/j.molcel.2009.09.022.
|This paper should be referenced as such :
|Huret JL
|Nervous system: Astrocytoma with t(1;17)(p36;q21) SPOP/PRDM1
|Atlas Genet Cytogenet Oncol Haematol. in press
|On line version : http://AtlasGeneticsOncology.org/Tumors/t0117p36q21ID5447.html
|Translocations implicated (Data extracted from papers in the Atlas)
|t(1;17)(p36;q21) SPOP/PRDM16
|External links
|Mitelman database
|t(1;17)(p36;q21) SPOP/PRDM16 [Case List] t(1;17)(p36;q21) SPOP/PRDM16 [Association List] Mitelman database (CGAP - NCBI)
|arrayMap ((UZH-SIB Zurich) [auto + random 100 samples .. if exist ] [tabulated segments]
|Disease database
|Nervous system: Astrocytoma with t(1;17)(p36;q21) SPOP/PRDM16
|REVIEW articles
|automatic search in PubMed
|Last year articles
|automatic search in PubMed
|© Atlas of Genetics and Cytogenetics in Oncology and Haematology
|indexed on : Thu Dec 28 15:02:16 CET 2017
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Kendall wows on coveted magazine cover
Kendall Jenner is on the cover of the latest issue of LOVE magazine, and she look simply stunning.
It's easy to forget that the 18-year-old made her name on a reality show, when you see the black and white shots inside the magazine by Mario Sorrenti.
Kendall says it was a dream of hers to work with Sorrenti: "I'd never worked with Mario Sorrenti, with whom I'd wanted to shoot nudes ever since that Kate Moss Calvin image of her nude on a sofa."
Well, we're sure she wasn't left disappointed with these shots! Who knew fishnet tights and a push up bra could be high-fashion? Wow.


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Physios in fear for patients over plans to move unit to old facility on far side of city
Physiotherapists working in a state-of-the-art department at Galway hospital have hit out at plans to move them to out-of-date facilities on the far side of the city.
Staff in the physiotherapy and social work departments at University Hospital Galway were informed of plans to move their departments in order to free up space for the overcrowded Emergency Department.
While social workers are facing a move to a prefab on hospital grounds, the physiotherapy department, which was purpose-built in the hospital, could be moved across the city to Merlin Park. Staff at the unit, which caters for 750 acute patients and 1,400 out-patients every month and has a specialist gym to help recovery, say the move will have a detrimental impact on patients and will cause a delay in discharging hospital patients.
While the acute patients would be treated in a smaller section in the hospital, out-patients would have to travel across the city to Merlin Park for treatment.
Padraig Mulligan of trade union Impact said physiotherapists and social workers are very concerned about the possible move and the effect it could have on patients.
"We intend to ballot our members on this. It's very serious and if this goes ahead, it's a move back 25 years," he warned.
The move will affect patients recovering from heart attacks, cancer, strokes, and also adults with cystic fibrosis.
Patients who have appointments with consultants in the hospital will now have to get a bus across the city to Merlin Park for their physiotherapy appointment.
"These patients are already travelling from as far away as Donegal for maybe chemotherapy or radiotherapy," said Mr Mulligan.
"They have already had a very long journey and now we expect them to get back on the road and travel across the city.
"We have an isolation room for cystic fibrosis adults which is vital but we're now talking about moving them out to an old building in Merlin Park as well. Physiotherapists are very concerned about this, they are worried about the impact on patients."
Physiotherapists also fear the move will cause a backlog in discharging patients.
"Most physios have both out-patients and in-patients and they are going to be travelling back and forth. The referral time right now is excellent," said Mr Mulligan. "In-patients are seen on the day of referral or the day after, but with this move, staff won't just be on hand to see in patients as needed. They fear that this will result in delays in treating in-patients and that will have a massive impact on recovery."
Concerns have also been raised about the possible move of the social work department to a prefab on the grounds of University Hospital Galway.
"They are basically being moved out to the middle of the carpark.
"These moves are short-sighted and staff fear they will cause serious problems," added Mr Mulligan.
Irish Independent


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Word mark
Logo design: Bottles or flasks, squat ; Bottles or flasks without neck ; Bottles or flasks with vertical, horizontal or other ribs ; Other bottles or flasks
The European Union Trademark for this logo was filed on 25.03.1999 for goods and services in class(es) 29, 30 and 32 at the European Union Intellectual Property Office (EUIPO). The current status of the trademark No. 001119122 is 'application withdrawn'.


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(Folks, We were certainly wrong about Petrus Romanus! please see essay and some new discoveries here. Yet we doubled down on the Geo-Earth Anomalies and found even more! Statistically impossible measurements all stretching forth from a location on the coast of Ghana. (see the very bottom for new illustrations) This Research is still very valid… […]
Georgia Guidestones book author completely rips SRI's research?
Whats up? For the authors of the latest "The Georgia Guidestones" book to completely rip SRI's documented research simply pointing out the many coincidences tying in possible commemorative Cover Art being issued 360 days prior to its building date simply because of "Biblical correlations" may give you a clue to this books true nature. As well […]
Deeper into the rabbit hole: The Harlot of Rev. 17, She builds monuments as well (part 2)
The Great Harlot of Revelation 17, She's a Super Tramp!
Supertramps Breakfast in America Cover Art & 9/11:
Presents New York City & The Statue of Liberty (in the guise of an all american 1950's waitress wearing a chilling nervous smile) along with the words Super Tramp above the great city. The waitress is holding up a "golden" cup on a serving plate right up to the twin towers whose mirror image show a clear 9-11 just above the buildings (The "Harlot" symbolizes the City, not the Statue/Waitress)
In the words from Rush's previous album 2112 based on Ayn Rand's science fiction novella "Anthem".
We have assumed control. We have assumed control. We have assumed control.
Supertramp 911, super tramp 9-11


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Visit us at the top of Market St. in Kettering Pop in for a cup of tea to discuss your mortgage at 2 Church Walk, Kettering, Northants NN16 ODJ
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Interest is usually calculated on a daily or monthly, rather than yearly, basis, so any overpayment you make immediately reduces your mortgage balance. By regularly overpaying your mortgage it is therefore possible to repay it early, saving you thousands of pounds in interest.
In order to underpay your mortgage, or take a payment holiday, lenders will require you to have built up an equivalent level of credit through overpayment first. You should also be able to borrow back the amount you have overpaid at any time. During in the term of a special rate you may be restricted to 10% overpayments per annum without penalty, terms differ from lender to lender.


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techxetra.org was registered 7 years 4 months ago. It has a alexa rank of #7,212,806 in the world. It is a domain having .org extension. This site has a Google PageRank of 3/10. It is estimated worth of $ 8.95 and have a daily income of around $ 0.15. As no active threats were reported recently, techxetra.org is SAFE to browse.
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Just another WordPress site
R.A. Heating offers fast and reliable air conditioning repair service including HVAC maintenance in Evansville, Madison and Janesville WI. Your local HVAC solution!
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Teen girl knew that girlfriend's bf is crazy, but poor teen couldn't imagine that maniac will ruin her life!
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This was judgment day for her.


text:
Recent Posts
Monthly Archives: October 2012
Move over quinoa, Freekeh's the new superfood to eat
Freekeh is the new quinoa! Not only is it fun to say but it packs a nutritious punch, too Carolyn Pioro Wed Jul 11 2012 Click here for the original article Photo credit: Getty Images There's a new grain in town … Continue reading
Posted in Uncategorized Tagged Canada, Cook, Freekeh, Jamie Oliver, Middle East, Quinoa, Superfood Leave a comment
Last weekend, St. Sarkis Armenian Church hosted the 17th Annual ArmeniaFest, a food and cultural celebration of the colorful Eastern European republic. People from all over the area came to help the church members honor their heritage by eating traditional … Continue reading
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Opa! Greek Festival Recap
Sara's Market and Bakery joined the community last weekend at the 56th Annual Greek Food Festival of Dallas. Despite the rain, everyone danced, shopped and ate their hearts out! Sara's pita accompanied Chicken Oreganato, Keftethes (Greek Meatballs), Spanakopita (Spinach … Continue reading
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Duty To Defend Suit Over Bratz Case To Continue
On Wednesday, Judge David O. Carter of the U.S. District Court for the Central District of California denied the insurance company's motion for summary judgment and partially granted MGA's motion.
The court granted MGA's motion to the...
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Colonial Medical Assisted Devices specializes in assisted living devices, medical supplies, wheelchairs, crutches, canes, senior living aids, assisted living aids, exercise equipment (...more)
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« Indonesia May Set Mandatory Use for Biofuel At 2-2.5% | Main | Traction Technology Opts for Enova Hybrid Drive in Bus Project with Supercaps »
Paradigm Sensors Launches Handheld Biodiesel Analyzer
4 February 2008
Paradigm Sensors launched its proprietary handheld biodiesel analyzer, which tests in the field for total glycerin, acid number, blend percent, and methanol, at the 2008 National Biodiesel Conference & Expo in Orlando, FL.
The Paradigm i-Spec Q-100 handheld analyzer tests the quality as well as the blend percent of the biodiesel to help assure that the biodiesel blend being used is in spec.
Our research indicates that our handheld analyzer will be the only field instrument to be able to measure methanol and blend percent in minutes and it is the only handheld analyzer that can test for total glycerin, acid number, blend percent, and methanol within minutes with readings that are consistent and reliable.—Dr. Charles Koehler, Paradigm Sensors
February 4, 2008 in Brief | Permalink | Comments (3) | TrackBack (0)
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Template >> Logo - Shield Logo 205697 by Krukowski @ CreativeMarket
File Size: 6.54 MB; Vector: Yes.
Shield Logo Template is premade logo perfect for security companies, antivirus software and similar. You can use it in both personal and commercial projects for yourself, your company or your customer. Text is editable so you can easily change company name, only free fonts were use.
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Keywords: vector, insignia, illustration, shield, symbol, premium, sign, round, quality, design, emblem, badge, classic, style, graphic, label, sticker, business, retro, stamp.


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Stagecoach West of Scotland League Central District First Division
Gasworks Park, Larkhall
Larkhall Thistle v Lanark
Larkhall Thistle got their home league campaign underway today with a win and the bonus of a rare clean sheet. A goal in each half from prolific striker Graham Gracie was enough to see off Lanark but in truth the scoreline could have been much more in favour of the home side and manager Dunky Sinclair must be pleased with the number of goalscoring chances created.
Goalkeeper Davie McEwan, defender Andy Brown and midfielder Mark Canning all recovered from injuries and started, in-form Jordan Marshall however was banned and the returning JP Grant could only make the bench.
Thistle got off to the perfect start and took the lead in the second minute when Gracie sprung the Lanark offshide trap and burst forward onto the ball, lifting it over the keeper into the net. After the early excitement however, the game settled down into a spell where neither side created any real clear-cut chances but Lanark were pressing well and probably had the majority of the ball.
The Jags should have added to their lead in the 32nd minute when Gracie chased down a ball that looked to be heading out for a throw in on the left wing. He managed to keep it in then burst past the Lanark defender, hit the byeline, looked up and picked out Ross McGeachie unmarked on the penalty spot and although the big man got his shot on target it was cleared off the line.
This was to be the turning point in the game as from then on almost every meaningful attack and chance created was by Larkhall. Mark Canning hit a tremendous dipping effort from 35 yards that the keeper just managed to get his hands to and five minutes later the midfielder repeated the feat, this time from a Gracie throw-in.
Lanark had a chance to level the game right on half time when a quick break caught the Jags defence on the hop but their striker fluffed his lines and Thistle went into the interval ahead.
Half Time: Larkhall Thistle 1 Lanark 0
The second half started with Thistle on the attack and Gracie setting the pattern for the rest of the game. He made a great run up the left side of the park and cut inside his defender, squaring the ball across the box but unfortunately nobody was on the end of the chance and it was cleared. Adam Cassidy then hooked a shot that was saved when he was first to a long Gracie throw, and Gracie again got involved when he outpaced the Lanark defence for the umpteenth time before being brought down just outside the box – but Canning gambled on the wall jumping and his low free kick was easily dealt with.
The chances were coming in waves now for the home side and Lanark hardly had time to draw breath before Ross McGeachie did well onthe right touchline and slipped the ball to Gracie who curled a fine effort just past the top left postage stamp. Canning then burst into the clear after a knock down right into his path sent him clear, but lobbed over when in all honesty he could have picked his spot.
The second goal however did finally arrive midway through the second half and was no more than Thistle deserved. The ball was played out wide on the right and the Lanark No15 in trying to deal with the ball only succeeded in heading into the path of Gracie who took a stride, looked up and smashed the ball high into the middle of the goal from just outside the box.
The Jags were in full flight now and two minutes later, as Lanark pushed in search of a goal, a long ball was nodded down perfectly by McGeachie into Gracie's path and he hit a fierce shot just past the post.
With twenty minutes left Andy Brown was replaced by Hugh Kelly with Niall Reynolds swapping to right back and Kelly going to left back.
Ten minutes from the end Gracie almost capped his outstanding performance with a hat-trick goal – and it would have been an early candidate for goal of the season. He picked up the ball in the middle of the park and set off on a run, evading tackles and hurdling lunging attempts to stop him and showing tremendous quick feet and control to take it all the way into the box before finally shooting wide.
So an excellent second half performance by Thistle, and Gracie in particular, and if this is what is in store for the rest of the season there won't be too many complaints from the home fans.
Full Time: Larkhall Thistle 2 Lanark 0
Thistle Scorers: Gracie 2
Larkhall Thistle Team:
McEwan; Brown, McMinn, Cassidy, Reynolds; McLachlan, Innes, Canning, McKeever; Gracie, McGeachie Subs: Kelly, Russell, Moss, Grant, Trialist
Best for Thistle on the day was Gracie who looks back to top form but there were good performances all through the side.


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Covering the military, politics, terrorism, fitness, guns and anything else that catches my eye...
Saturday, January 09, 2016
Are you watching this game?
I like football but this Pittsburgh/Cincinnati matchup is just a terrible watch. I have never seen a group of more undisciplined, selfish, childish, moronic athletes before in my life (yeah I'm talking about the CIncinnati Bengals).
The NFL needs to fix this shit or they're gonna lose viewers. Oh and playing in the league is a privilege, not a right. If you don't know how to behave then you don't belong in it.
Just plain terrible.
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The Impact of Legalized Abortion on Crime
We offer evidence that legalized abortion has contributed significantly to recent crime reductions. Crime began to fall roughly eighteen years after abortion legalization. The five states that allowed abortion in 1970 experienced declines earlier than the rest of the nation, which legalized in 1973 with Roe v. Wade. States with high abortion rates in the 1970s and 1980s experienced greater crime reductions in the 1990s. In high abortion states, only arrests of those born after abortion legalization fall relative to low abortion states. Legalized abortion appears to account for as much as 50 percent of the recent drop in crime.
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
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Volume (Year): 116 (2001)
Issue (Month): 2 ()
Pages: 379-420
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We live up to our motto, "Any Seal, Any Time." For all your o-rings (available in Viton®, neoprene, silicone and NBR), inch and metric size shaft seals, fluid power and stem seals, and o-ring service kits. We work hard to provide you with the highest quality products and service. O-Ring Seals in Minnesota.
Minnesota Rubber & Plastics, a division of Quadion, is an o-rings manufacturer of rubber o-rings, silicone o-rings, buna o-rings and EPDM o-rings. Minnesota Rubber & Plastics offers many services and secondary operations for our full line of high-quality rubber products. We offer standard products or those manufactured to your specifications. O-Ring Seals in Minnesota.
Precision Associates is a manufacturer of close tolerance, precision molded rubber seals and custom rubber products. We have over 2600 sizes of O-Ring molds and many other types of seals, such as, U-Cups, X-rings, rubber to metal bonded seals & much more- find what you need with the custom service you want!O-Ring Seals in Minnesota.
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