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SOURCE: Persistent Systems
March 22, 2013 04:16 ET
R&D Program to Accelerate Mechanism-Based Drug Discovery, Help Eliminate Use of Animals in Contact Allergy Testing
R&D Program to Accelerate Mechanism-Based Drug Discovery, Help Eliminate Use of Animals in Contact Allergy Testing
PARIS and PUNE, INDIA--(Marketwire - Mar 22, 2013) - Bio-Modeling Systems (BMSystems), a leading integrative systems biology company and, Persistent Systems (BOMBAY: PERSISTENT) (NSE: PERSISTENT), the global leader in software product and technology services, today announced a joint systems biology research and development initiative. The strategic initiative is the world's first collaborative effort that marries non-mathematical heuristic modeling with mathematical modeling designed to increase the success rates of drug discovery and formulation development by pharmaceutical and cosmetic industries. A key deliverable of this joint initiative is the development of a predictive in silico or computer simulated skin model that will help eliminate the need to use animals in contact allergy testing. Today's announcement follows on the heels of the European Union's ban on the import and sale of cosmetics containing ingredients tested on animals, offering the industry a highly effective and essential alternative.
Bio-Modeling Systems' team of highly skilled biologists will combine the outputs of its CADI*™ proprietary heuristic modeling platform with a powerful new software platform, Cell-in-Silico, developed by Persistent, resulting in the first heuristic model of skin cell interplay mechanisms to be enhanced through mathematical modeling. This strategic collaboration harnesses the scientific and bioinformatics capabilities of Bio-Modeling Systems and the information technology and scientific capabilities of Persistent Systems to provide the first ever truly holistic systems-based drug discovery solutions.
"Bio-Modeling Systems and Persistent Systems have come together to develop a much needed solution that will address the pharma and cosmetic industries' need for predictive modeling of skin in silico," said Dr. Anand Deshpande, Managing Director and CEO, Persistent Systems. "Bio-Modeling Systems scientists have pioneered heuristic biological modeling with their CADI™* platform. By coupling this with Persistent Systems' strength in mathematical modeling and IT, we will develop a viable in silico alternative to animal testing."
"We are delighted to partner with Persistent Systems' life sciences experts, as together we can bridge the gap and powerfully link complementary heuristic and mathematical modeling," said Manuel Gea, CEO, Bio-Modeling Systems.
"For the first time ever, mechanistic modeling and dynamics engineering will be merged, bringing a whole new level of understanding to the multi-scale biological space, enabling us to develop a fully integrated, outstanding set of solutions to previously intractable biotechnological problems," said Dr. François Iris, CSO, Bio-Modeling Systems. We look forward to addressing the industry's challenges head-on with this powerful offering."
About Bio-Modeling Systems (BMSystems):
Bio-Modeling Systems, an innovative company founded in 2004, is the first and, to date, only company to successfully create in-silico heuristic models validated in-vivo. BMSystems' heuristic models, built by its biologists using an integrated IT solution called CADI ™ (Computer Assisted Deductive Integration) have led to discoveries, patents, and operational businesses in the fields of infectious diseases, immunology, neurology, psychiatry, oncology, dermatology and innovative bioprocesses for industrial biotech. BMSystems' models describe the biological phenomena involved in pathological states and provide new mechanisms to explain the cause of certain diseases, identify and select predictive biomarkers, offer new combinations of molecules and new therapeutic strategies contributing to the development of Mechanism-Based Medicine.
For more information, please visit http://www.bmsystems.net.
About Persistent Systems:
Established in 1990, Persistent Systems (BOMBAY: PERSISTENT) (NSE: PERSISTENT) is a global company specializing in software products and technology services. For more than two decades, Persistent has been an innovation partner for the world's largest technology brands, leading enterprises and pioneering start-ups. With a global team of more than 6,000 employees, Persistent has 300 customers spread across North America, Europe, and Asia. Today, Persistent focuses on developing best-in-class solutions in four key next-generation technology areas: Cloud Computing, Mobility, Analytics and Collaboration, for telecommunications, life sciences, consumer packaged goods, banking & financial services and healthcare verticals. For more information, please visit: http://www.persistentsys.com.
Forward-looking and Cautionary Statements: For risks and uncertainties relating to forward-looking statements, please visit:
All trademarks, trade names, service marks, and logos referenced herein belong to their respective companies.
Media Contacts:Rashmi Joshi
Persistent Systems, Ltd.
+91 83083 39400Email Contact
Ilona Mohacsi
PenVine for Persistent Systems, Inc.
+1 631 764 3729Email Contact
Manuel Gea
+33 683061272Email Contact
Media Contacts:Rashmi Joshi
Persistent Systems, Ltd.
+91 83083 39400Email Contact
Ilona Mohacsi
PenVine for Persistent Systems, Inc.
+1 631 764 3729Email Contact
Manuel Gea
+33 683061272Email Contact
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The University of Western Ontario - Western provides the best student experience among Canada's leading research-intensive universities.
University-age students today are sometimes referred to as 'digital natives' – a group of people who have grown up with the Internet. But many young people are unsure of how to use computers and the Internet beyond social media or web-browsing purposes. Librarians are now helping students fill this digital void.
Libraries are looking to teach students how to optimize research and many now offer workshops on how to make sense of the information they find. Librarians provide instruction on how to search efficiently within academic databases, using simple tricks such as adding brackets and asterisks to narrow down searches.
Nowadays, it's important to recognize not all students are tech-savvy and for libraries to have support services for students through liaison librarians. These librarians spend time in research-intensive classes introducing students to the library resources available to them.
Read more here: http://communications.uwo.ca/western_news/stories/2012/November/librarians_move_to_fill_void_for_digital_natives.html
Via Fe Angela M. Verzosa

subset: commoncrawl


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What's New: Residential Technology
What's New: Residential Technology
Mar 1, 2008 12:00 PM, By Laura Dixon and Eric Melin
High-end sound technology is proving to be a key element in the design of leading hotels, so the presence of an Artcoustic AV system at the Radisson Edwardian Leicester Square Hotel in Copenhagen, Denmark, perfectly complements the hotel's luxurious standards.The Diablo monitors, together with Dfs 100-75 loudspeakers and Dfs 75-55 subwoofers, have been beautifully integrated into the hotel's lobby, restaurants, and bars. The unobtrusive systems allow guests to dine or enjoy drinks in an elegant acoustic environment aligned with the aesthetic experience of the entire hotel.
▪Artcoustic | www.artcoustic.com
Soundations has expanded its Designs Unlimited product offerings, including numerous flatpanel-TV and corresponding audio-and-video component furniture from the South African designer/manufacturer. The products are an extension of an interior design's aesthetic requirements. According to Soundations, the new pieces provide high-quality choices for consumers to house their home theater system components. The multiple available flatpanel-mount stands and corresponding AV and media furniture are created with real wood veneers available in seven finishes, including maple, redwood, cherry, wengé, black, silver, and glass.
The new Elite Screens VMax2 in-ceiling screen-installation kit makes it easier to install the electric-projection screen for any conference or media-room project. The slotted-plate attachment protects an Elite VMax2 screen from beneath while cradling it securely in specialized fittings designed to accommodate screen sizes from 84in. to 150in. in either 4:3 or 16:9 aspect ratios, with custom-sized options available. The framework is adjustable to standard spacing requirements, and it secures easily to internal studding. The enameled sheet-metal design is durable for long-term use, and it provides easy access to the screen itself from the ceiling space.
▪Elite Screens


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Still looking for a summer camp for your children? Interested in a free workshop to improve your gardening skills? It's not too late to sign up for these summer programs hosted by the University of Rhode Island at the Roger Williams Park Botanical Center and Community Garden.
The Eco-Exploration Camp runs for three weeks on Tuesdays and Wednesdays from 9:30 a.m. to 1 p.m. beginning on Aug. 7. Open to children ages 8 through 12, the camp teaches children about urban wildlife and how to study them, including learning techniques for collecting insects, tracking mammals and cataloging the birds that use the garden as habitat. Participants will also play nature-themed games, make arts and crafts projects, and draw in a natural journal.
"The children's garden at the new Roger Williams Park Community Garden is the perfect setting for kids to learn about growing healthy food and discover the diversity of nature found in urban green spaces," said Vanessa Venturini, the coordinator of the URI Learning Landscape Program.
Each weekly camp session costs $50 and includes lunch. The free gardening workshops take place on Saturdays in July, August and September beginning at 10 a.m. Sessions include composting that was held on July 7, attracting beneficial insects (July 14), maintaining your gardening tools (July 21), extending the gardening season (Aug. 4), tree and shrub care (Aug. 11), taming your tomatoes (Aug. 18), cooking with herbs (Sept. 8) and putting your garden to bed (Sept. 22).
Registration for the gardening workshops is not required.
For more information about the camp or gardening programs, visit www.uri.edu/cels/ceoc/ or call Vanessa Venturini at 874-7142 or email email@example.com.


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Darlene Hickey
Darlene Hickey, 59, of Killeen, Texas, formerly of Big Spring died Sunday, Nov. 27, 2011, at her residence. Graveside funeral services will be held at 2 p.m. Saturday, Dec. 3, 2011, at Mt. Olive Memorial Park Chapel with the Rev. Randy Hardman, pastor of First Baptist Church of Gail, officiating.The family will receive friends from 6 p.m. until 8 p.m. Friday, Dec. 2, 2011, at the funeral home.Darlene was born March 21, 1952, in Big Spring, Texas, and married Dean Hickey on Nov. 25, 2006, in Killeen. She graduated from the University of Mary Hardin-Baylor in 1989 and worked for many years as a dialysis nurse. She is survived by her husband, Dean; one son, Matthew Douglass; one daughter, Tracy Sibole and son-in-law, James; one sister, Deniese Warner; and two granddaughters.She was preceded in death by her son, Warren Swett, and her parents, Raphael "R.W." and Nora (Davis) Buchanan.Arrangements are under the direction of Nalley-Pickle & Welch Funeral Home & Crematory of Big Spring. Online condolences can be made at: www.npwelch.com


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Message Board
Penny Mickelbury Message Board
Talk about the novels, new and used books that Mickelbury has written!
Author Mickelbury's Book Reviews
Paradise Interrupted
Simon & Schuster, Feb 2001, 23.00, 288 pp. ISBN: 0684859912 As a defense lawyer with her own security firm, co-owned with Jake Graham, African-American Carol Ann Gibson lives the American dream. Carol and Jake have offices on both coasts and are so popular they have a large international clientele. Their latest customer is the Caribbean nation Isle de Paix, who recently had a bloodless coup that replaced its Communist leader with an i...


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Write some Articles
Presupuesto $750-1500 USD
Looking for someone to write 3-4 weekly blog posts regarding natural skincare and beauty products.
40 freelancers están ofertando el promedio de $898 para este trabajo
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Find 35% Upside with Baidu
Baidu, "the Google of China," looks cheap just as growth is poised to accelerate, Barron's Jack Hough says on MoneyBeat.
This transcript has been automatically generated and may not be 100% accurate.
... ay ay mm mm ... Chinese teas is full of foreboding ... for investors they may still be opportunities ... worth taking a risk on Jack Allen joins us now when Chinese name you might wanna take a look at Jack ... all its own Canadians ... you and all related China today for one I did I'm ... feeling a bit of jet lag know I I ... the the the Chinese stock markets got pounded some thirteen percent this year was the U S market is up thirteen percent ... Barron's had a cover story a couple weeks ago talking about the credit crisis in China ... and how this this unreal Proms Humira saw its by no means time to go in and buy with both hands by a good thing it's time to identify some quality assets ... look for the right price is among those that might be ... at the right price now is because Baidu that's the commonly ... called the Google's China it's the search leader over their seventy percent share of paid search ... aam ... it's about it in the same prices and valuations goal right now around nineteen times earnings ... but the key for this company is ... is not earning any were near its potential ... I'm not talking just about the good growth potential for the Chinese in any market ... or ... visit the Wall Street expects earnings to grow by a ninety percent in in total over the next three years ... while the keys here is a company makes just about all of its money from paid search ... and if you look at Google Google makes nearly a third of its ad revenue from these that you have this ad marketplace work and put ads on third party sites ... Baidu is just getting and that now that it hasn't started ... to really a lot of growth potential as it goes into ... can you have is I think the stock is cheap ... free cash for rain out about six percent of stock price that suspected climbed to about ten percent a stock price over the next few years ... ALM ... so I you know it looks cheap enough now if the economy did the Chinese stock market the devil nor ... do they operate anywhere outside of China or the chances of them operating ... in China I don't know but merely to sense eye to the euro the overwhelming majority is in China right now ... but there's plenty of potential there you know ... the Internet ... penetration China is wrong does around forty percent of persons ... seventy five to eighty percent of most of all markets ... new growth opportunity and rather aggressively building broadband infrastructure ... ad dollars are for her income and the American that same thing that has happened here ... no parallel with Google because we saw on Google ... Gets are being down during the financial crisis to be had here ... it's been a tremendous performer cents on the stock has doubled in price over the past four years ... I think if that is ... a similar opportunity booming in Baidu I'm not sure the stock is as ... at the bottom yet to come from ... one fifty a couple years ago to the lower nineties right now last weekend ... on risk factors and China's Sentinel peak market this is so much that goes on there ... and especially from Jia ... you can really get a feel for you can get a sense of ... how much we keep upon the risk of investing in China this is the play a stock with elevated risk in the now and that the malaise which is that that the former scarily have ... ownership of one of these Internet properties this is some ... sort of elaborate set of contract allows us to trade overseas for foreign investors sodas ... sort of on chart and regulatory territory ... I think the valuation is compelling enough to take a look at it ... like I said you know this is not the time to to avoid a retirement money into China ... it is time to identify a couple of high quality assets over there and look for the right price I think this was are you weed out the right price now you might even see a better deal if you have some sort of a down year for the downturn in the Chinese stock market ... Jack Lew Aksland stuff as always thank very much


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truth5678 wrote:I presume this limit is "nearby" to the function "BIOS_AddKeyToBuffer", but I've yet to find the exact cause of the 15 character limit.
Maybe because the BIOS keyboard buffer can hold a maximum of 16 keystrokes? However, it's possible to install a relatively simple device driver or TSR with a larger buffer that feeds into the BIOS buffer as entries become available, which could be useful when "stuffing" many keystrokes.


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I'm currently wrestling with exactly how to load London addresses into my genealogy file. This isn't such a problem for non-London addresses as the parish and village are generally the same and the street name is often non-existent.
In the source attached to any event I've been quite specific in listing full parish name (eg St David West Holloway), then the broad suburb (eg Islington), then county (eg Middlesex). However in terms of actually filling in the address field of the event the lines get blurred.
Part of the problem I think stems from the fact that PAF only has a certain amount of space to print addresses, so I know it will abbreviate parts of it to initials only when I print out the individual's summary page - understandable, but useless in practice. This means I have a tendency to try and abbreviate things myself - no point putting "24 Alfred Street, St David West Holloway, Islington, Middlesex" when I know on printouts it will just show "24 Alfred Street, SDWH, I, Middlesex". I'm thinking I might change my self-imposed rule and just put the Chapman code for the county instead of spelling out the county in full but this won't get me back that many characters.
Another part of the problem is the fact that I'm not a Londoner myself so my geographical grasp of suburbs is probably pretty shaky - it bugs me that I don't know if I'm using the name it would actually be known as in practice! I've just printed out most of the sections of this excellent 1877 parish map, and I think I could standardise this by using the poor law union name as the suburb name.
My brain also wants to use "London" rather than "Middlesex", even though London should only really be used for the City of London area.
And don't even get me started on the frequent parish boundary changes and name changes for those London parishes!
Does anyone have any suggestions as to how they approach this? Do I really need to include the parish name as part of the address so long as I've got it in the source? Am I overthinking the whole thing?
Tuesday, April 13, 2010
London addresses
I'm currently wrestling with exactly how to load London addresses into my genealogy file. This isn't such a problem for non-London addresses as the parish and village are generally the same and the street name is often non-existent.
Posted by Unknown at 6:44 pm
1 comments:
- Anonymous said...
When you say suburb, you probably mean the borough, I use the list on the LMA website http://www.cityoflondon.gov.uk/londonGenerations/download/Places%20in%20London%20Boroughs.pdf to find which borough the parish is in.
Having said that I don't usually use the borough in my address records, I just stick to parish, county, country. I know I should use it, but I wanted to try and keep the format the same for rural and urban addresses. I think it might be time for me to revisit my places and add in the borough.
- 13/4/10 7:54 pm


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Gigabyte GA-78LMT-USB3 features humidity protection, humidity can play havoc on a motherboard's circuitry. Gigabyte's glass fabric PCB design helps protect against electrical shorts due to humidity by reducing the gaps in spacing between PCB filaments.
Permanent damage from power surge or failure during BIOS update can be avoided with Gigabyte DaulBIOS, which automatically enables a secondary, back up BIOS. Gigabyte also uses Anti-Surge ICs to protect the motherboard against power surges.


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My wife and I are both beginner kiters. She's about to work on her waterstart and I can ride about 50 to a 100 meters before crashing. We currently own a 2010 Ocean Rodeo Rise 11m kite.
We're looking to buy a second kite and next year probably a third. I weigh 195 lbs and her weight is 160 lbs.
Would a 9m kite be right for us now and later a 7 meter? Or should we get an 8m kite and later a 6m? We're looking to kite around Vancouver and for vacations in Maui, Mexico and the Caribbean.
Your comments are greatly appreciated! Thanks.


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After a party on Wednesday night, I found myself walking down part of the Hollywood Walk of Fame. Take a look at what I found:
(Give it up for John Ford.)
(This star has been trashed and a little defaced. What is the name under all that muck? "Michael Jackson." It appears to be the star for the radio personality of the same name and not the King of Pop. Looks like people are directing their vandalizing on the wrong star.)
(Give it up one more time for Harold Lloyd.)
(Roy Rogers got screwed here. Not only is the top of his star missing, but there's this city construction sign hovering above it.)
Sign Up: Stay on top of the latest breaking film and TV news! Sign up for our Email Newsletters here.


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These dainty little tarts are as easy to make as they are beautiful.
These dainty little tarts are as easy to make as they are beautiful.
These diminutive desserts are perfect vessels for sliced fresh fruit, a guilty shot of ganache, pastry cream or canned pie filling.
They�ll easily accommodate instant pudding (just use a little less milk when making it) or a dollop of ice cream.
They�re so easy to make and fill, you can whip up several shapes and sizes in no time at all.
1/4 cup chocolate, white chocolate or butterscotch chips per 3-inch tart Instructions:
These are easiest made with silicone baking cups. Alternately, chocolate can be melted and pressed into a plastic wrap-lined cup.
Heat an inch or less of water in a saucepan. Bring to a boil and then reduce heat to a simmer. Place chips into silicone cups and float the cups into the water. As the chips begin to glisten and reach melting point, press chocolate down and up the sides to -inch or more thickness. Cool and unmold.
4 egg whites
1/2 teaspoon cream of tartar
1 cup sugar
2 teaspoons vanilla
Beat egg whites with cream of tartar until foamy. Very gradually beat in sugar and continue to beat at high speed until stiff peaks form.
Beat in vanilla. Line a baking sheet with foil (grease lightly) or parchment paper. Pipe into shapes with a pastry bag or outline a shape on parchment paper. Fill in shape with meringue and then build up a rim around the edge of base from 1 to 2 inches thick.
Bake at 250 degrees for about 30 minutes, or up to 40 minutes. Outside should be crisp and the inside still a little moist. Take out of oven and let air dry or turn off oven and leave in oven for 1 hour.
Note: For chocolate meringues, gradually fold in 2 tablespoons cocoa after soft peaks form.
1/2 cup heavy whipping cream
2 tablespoons ( stick) unsalted butter
1 tablespoon light corn syrup
8 ounces bittersweet chocolate
Combine cream, butter and corn syrup in a pan over low heat. Bring to a boil. Meanwhile, chop chocolate into smaller pieces. Remove milk from heat, submerge chocolate. Let rest 5 minutes and then combine. Add to tarts while still at a spreading consistency. If desired, allow to reach a puddinglike consistency and then whip briefly for a lighter filling.
Enough to fill 6 (4-inch) tarts
6 prebaked pie shells
2 tablespoon all-purpose flour
2 tablespoons light brown sugar
1/2 cup unsweetened coconut
2 tablespoons butter
2 or 3 bananas, not too ripe
1/4 cup Nutella
Combine flour, sugar, coconut and butter into a crumbly mixture. Peel and slice bananas and create a single layer on the bottom of a prebaked crust. Spread Nutella over the banana to cover. Divide crumbly mixture among the tarts and loosely spread. Bake for 15 minutes, until the crumble starts to brown. Serve warm or at room temperature.
3 cups milk
1 teaspoon vanilla
6 egg yolks
2/3 cup sugar
1/4 cup cornstarch
1 tablespoon cold butter
In a saucepan, heat milk and vanilla to a boil over moderate heat. Immediately turn off heat and let sit for 15minutes. In a separate bowl, whisk egg yolks. Mix cornstarch and sugar and whisk into egg yolks until fluffy. Take one quarter of the warm milk and add to the egg mixture to temper it. Continue this process until the eggs and milk are mixed together.
Pour milk and egg mixture back into saucepan. Cook over medium heat, whisking constantly until thick.
Remove from heat, add butter, stir until mixed. Pour half of mixture into a bowl. Cover with plastic and chill before using. Pour 1/4 cup chocolate chips into remaining mixture. Stir until chips are incorporated. Cover with plastic and chill.
This recipe, made without the chocolate chips, tops a tropical chocolate eclair cheesecake pie in �Pie-ography: Where Pie Meets Biography, 42 Fabulous Recipes Inspired by 39 Extraordinary Women,� by Joe Packham (Fair Winds Press, $24.99). It�s perfect for filling tart shells.


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3.1 Phillip Lim
Jason Wu
Proenza Schouler
The Row
Theyskens' Theory
that mustard coat in the phillip lim collection is AMAZING!
also love the last dress on jason wu and the rodarte collection is so dreamy.
my favourites too. the row was a particular highlight, such simple and sophisticated clothing.ReplyDelete
The Jason Wu stuff is great.ReplyDelete
I now want a Proenza Schouler jumper in my wardrobe! They look so big and comfy yet very stylish!
I found the Phillip Lim collection very stylish, and Proenza Schouler has got such awesome patterns. Oh, and the Rodarte collection seems like fashion made for goddesses!
became a phillip lim fall'11 rtw collection fan after your post. love the green everywhere in it. And the coats. did an own selection on my blog.
like the second "rodarto" robe as well as the first of "Theyskens' Theory".
I've always loved Jason Wu & Phillip Lim's fashion sense...probably biased since I like the effortlessly chic look :)ReplyDelete
I haven't been able to follow up with NYFW for the past 2 days, but so far I'm really in love with Erin Fetherston and Jason Wu's collections!
I see that 3.1 Philip Lim has amazing stuff this season too (:
♥ ♥ ♥
definitely rodarte! and jason wu.
but i love the mustard coat at 3.1 phillip lim is beautiful as well
oh Jason Wu definitely! perfect balance of minimalism, sophistication, and feminism.ReplyDelete
I love the Jason Wu!!!!!
I love your blog, I follow you!
Rodarte, The Row and Jason Wu really did a good show!ReplyDelete
The 3.1 Phillip Lim trousers are to die for, and I also fancy Proenza Schouler's.
Luuve ur blog! <3
Very inspiring! There is always something special about Proenza Schouler. Can't tell what it is, but they always seems to nail it! haha. The Row looks pretty amazing too.ReplyDelete
proenza schouler!ReplyDelete
Nice pictures ! 3.1 Philipp Lim <3 btw i love your blog!
Visit mine ;) http://toffeeandapples.blogspot.com/
philip lim is always my ultimate fave! proenza is always amazing too.


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Our Fitness Blog
The Impact of Cardio and Fitness on Heart Health
People who engage in regular physical activity derive many important benefits. Not only is it easier to maintain a healthy weight with regular cardio exercise, but many people also find that they have more energy for completing daily tasks when they live an active lifestyle. Getting daily exercise often helps with overall mood, helping people feel more positive and happy. Exercise can help people sleep better at night also. And exercise is an effective way to maintain good health, helping people avoid specific diseases such as heart disease and diabetes.
Lifestyle can have a major impact on whether somebody develops heart disease. Eating a healthy diet, avoiding obesity, and exercising regularly are three components of a healthy lifestyle. The surgeon general has made formal recommendations regarding physical activity for adults. For optimal health, adults should engage in cardio exercise of moderate intensity for at least 2.5 hours every week. "Moderate intensity" will vary for everyone depending on their individual fitness level. To determine whether you are exercising at moderate intensity, use the "talk test." When exercising at this level, you should be able to carry on a conversation, but you would not be able to sing.
Abundant options exist for exercising at a moderate intensity level. Choose different types of exercise to keep yourself engaged. You might take a bike ride at a speed of at least 5 miles per hour, take a brisk walk, jog moderately, play golf while carrying or wheeling your own clubs, play tennis, engage in water or traditional aerobics, dance, or push a lawn mower. Exercise at the moderate intensity level will burn between 3.5 and 7 calories each minute.
Exercise performed at the moderate intensity level or higher helps make the heart stronger. As the heart gets stronger, it pumps blood more effectively. This enhances blood oxygen levels, which helps improve overall cardiovascular health. Cardiovascular heart disease involves the buildup of plaque in arteries. As plaque builds, less blood can pass through arteries. This situation results in less oxygen being carried throughout the body. Eventually, as plaque accumulates, it may rupture. Blood clots can also form on the plaque. These issues can lead to blockages in arteries, which could lead to a heart attack. As someone exercises, their blood pressure lowers. Exercise also helps increase one's HDL cholesterol level, which is beneficial for overall health.
Exercise that strengthens muscles is also beneficial for cardiovascular health. This type of exercise generally involves lifting weights or performing resistance training to force the muscles to hold weight. It's also possible to perform resistance training using body weight. Examples of this type of exercise include push-ups and chin-ups. Elastic bands can produce effective resistance when used to perform specific exercises. With regular strength-building exercise, muscles will become stronger. Resistance training can help lower blood pressure, which will have a positive impact on overall cardiovascular health. Engaging in resistance training for at least 30 minutes three times per week can be an effective way to improve heart health.
A sedentary lifestyle is associated with health problems. Sedentary activities involve anything that requires only a low level of energy to complete, such as watching television, working at a desk, or driving. People who spend a significant portion of their day sitting have an elevated risk for cardiovascular problems. Even some physical activity is better than doing nothing. People will derive more health benefits as they increase their physical activity level. For the most benefit, people should perform cardio exercise at the highest intensity they can safely and comfortably achieve. Performing this activity should also occur as often as possible and for as long as possible. Children and teenagers should also get regular exercise to maintain good health. In general, the benefits of exercise are far greater than any negative results that might occur.
Educate yourself on the many benefits of cardio exercise for maintaining cardiovascular health with these resources:
- Benefits of Physical Activity
- Heart Disease Prevention: What You Can Do
- Physical Activity Has Many Health Benefits
- Aerobic Exercise Intensity and Target Heart Rate
- Heart Health (PDF)
- Cardiovascular Health
- What Can I Do to Prevent Heart Disease?
- 10 Minutes to a Healthier Heart (PDF)
- Heart Disease and Stroke Prevention (PDF)
- What You Should Know About Cardiovascular Disease (PDF)
- Take the Plunge for Your Heart
- Sitting Too Much, Not Just Lack of Exercise, Is Detrimental to Cardiovascular Health
- Benefits of Exercise
- Study Shows Resistance Training Benefits Cardiovascular Health
- 10 Tips to Prevent Heart Disease and Stroke
- Preventing Heart Disease
- Cardiorespiratory Endurance (PDF)
- What's Moderate-Intensity Exercise?


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"DM Executive" for SIG 1911 Nitron w/Rails
KIRO's Vertical Closed-Muzzle Shoulder Holster is designed for a comfortable concealed carrying. Mostly suitable for people that spend a long time behind the wheel. The Adjustable leather harness allows an easy adaption of the straps to any chest up to 48″.
The belt tie down at the pistol's side keeps the gun in place and secures the hummer from undeliberate shooting.
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Standards have long been an integral component of education.
For decades, public, private and Catholic schools have relied on standards to craft curriculum and measure student achievement. In several instances, Catholic schools have taken the states' public school educational standards and adapted them to reflect their Catholic values.
"For our schools to not be aware of what the public school academic standards are, to not be familiar with where our students need to be, that would be irresponsible. In fact, I don't think parents would expect us to not be aware of those things," said Sister John Mary Fleming, executive director of the U.S. Conference of Catholic Bishops' Secretariat of Catholic Education.
Catholic school leaders across the country now are responding to the latest trend sweeping public education in the United States: the Common Core.
So far, 45 states have signed on to the Common Core, which is a set of educational standards in English language arts and mathematics for students in kindergarten through the 12th grade. The idea of the Common Core State Standards is to create a universal set of expectations for each grade level so that, for example, a sixth-grade student in South Carolina will be as well-educated as a sixth-grader in the Northeast.
"There has been great concern related to academic rigor in the country for quite some time," Sister Fleming said.
Supporters of the Common Core say the standards are challenging, built on a coherent philosophy of how students learn and retain information, and that they represent a shift from rote memorization and fill-in-the-bubble test-taking toward an educational system based on solid writing and reasoning skills also marked by an understanding of abstract mathematical and English language concepts.
"We feel the Common Core State Standards are rigorous, more clear and better aligned than previous standards," said Kevin Baxter, superintendent of elementary schools for the Archdiocese of Los Angeles, which this year is implementing the Common Core's English language arts standards.
But not everyone agrees.
In what is already a polarized political environment, some critics see the Common Core State Standards as a thinly-veiled national takeover of education that will erode local control from parents and teachers.
Meanwhile, several Catholic scholars and observers have criticized the Common Core for what they see as a pragmatic, bottom-line approach focused more on providing a baseline of basic knowledge and skills necessary for beginning college or entering the job market, rather than on educating the entire person, which is part of the unique mission of Catholic schools.
The dissenting Catholic scholars also say the Common Core's emphasis on reading "informational texts" — such as magazines, journals and newspaper articles — comes at the expense of studying great works of literature.
"With the Common Core, it's coming out of the public school system, and it has a very utilitarian twist on education. It's basically saying, 'Our mission is college and career readiness," said Dan Guernsey, the headmaster of the Rhodora J. Donahue Academy of Ave Maria, a private K-12 independent Catholic school near Naples, Fla., that espouses a classic Catholic education rooted in teaching the classics of Western Civilization.
Common Core's supporters counter that the new standards do not curtail literature, but Guernsey, who also serves on the board of trustees for the National Association of Private Catholic and Independent Schools, touched upon a key component of the Common Core opposition when he told Our Sunday Visitor that Catholic schools have a different nature and mission than their public counterparts.
"Our mission is much broader, much more focused on the human person," Guernsey said. "College and career-readiness is a natural byproduct of what we do, but it's not why we do what we do."
Concerned that students in the United States were lagging far behind their peers in other developed countries, the nation's governors and education commissioners — through the National Governors' Association and the Council of Chief State School Officers — encouraged the development of the Common Core State Standards in 2007.
Officials said teachers, researchers and leading education and childhood experts developed the Common Core's standards in English language arts and mathematics, which some states began adopting in 2010. The states that have adopted the Common Core will begin using assessment tests aligned to the standards in the 2014-15 school year.
Supporters say the Common Core builds on the highest standards that some states have already been using. The idea is that by the end of each grade level — in an "ascending staircase" of expectations — the students will have mastered the same basic skills and attained a common baseline of knowledge.
The National Catholic Educational Association has called the Common Core a set of "high-quality academic expectations" that represents a "fundamental shift" in the teaching and learning process.
"There is a new emphasis on reading non-fiction and improving reading skills across the curriculum, and that comes from colleges that have complained for years that [incoming freshmen] students are not prepared to read and use college texts," said Sister Dale McDonald, the director of public policy and educational research for the National Catholic Educational Association.
The Common Core's English language arts (ELA) standards contain at least six noticeable shifts in how students are taught reading and writing.
In what is perhaps the most controversial shift, the Common Core places a higher emphasis on reading informational, or nonfictional, texts. Based on the premise that 80 percent of what people read in college and their careers is informational, the Common Core says students, by the time they are in the 12th grade, should have 80 percent of their reading course-load as informational.
The Core's ELA standards also demand students engage a text on its own terms. Rather than using one's own value system, the student is now asked to analyze a text by the author's thinking.
For example, instead of trying to relate one's experiences to the Rev. Martin Luther King's "Letter from a Birmingham Jail," the student now might be asked to speculate on what prior correspondence informed King's letter.
That idea, critics say, is problematic because students might not be allowed to analyze a text in the light of universal truth or the Catholic intellectual tradition.
"We want our students' education to be based on transcendent truth, not the truth in the world of the text," Guernsey said.
Meanwhile, the new ELA standards also call for students to cultivate an "academic vocabulary" so they can understand words that they will read in articles but not encounter in everyday conversations.
Students are also expected to present arguments and points of view in writing, to read primary sources in social studies classes instead of textbook summaries, and to become fluent in the technical language terms in other academic disciplines.
For the Core's math standards, fewer concepts are introduced in the early grades, the idea being that students should master fewer basic concepts before advancing to more difficult topics. With that in mind, students would not learn multiplication and division until the third grade. Algebra would not be introduced until the ninth grade.
The new math standards also place a premium on understanding abstract mathematical principles, which some observers agree with, but they warn that younger students should still be taught the mechanics of adding and subtracting before they are asked to understand those principles intellectually.
Several media outlets have reported that at least 100 Catholic dioceses have adopted the Common Core State Standards or adapted some of their elements. The USCCB's Sister Fleming said she could not confirm that number, but added that several dioceses have been comparing and contrasting the Common Core to their previous standards.
"They've done what we would call picking and choosing the best and not using the parts that they don't think are going to be helpful with their academic rigor," Sister Fleming said. "Some dioceses have taken quite a bit of the Common Core. Other dioceses have used it as one of many resources they would normally use. I think the dioceses are looking at it in a larger framework of helping their students be academically prepared for college.
"Many superintendents are looking to see how the standards support the Catholic culture in their schools," Sister Fleming added.
Timothy J. McNiff, superintendent of schools for the Archdiocese of New York, told OSV in the fall that his school system was adopting the Common Core, adding, "To us, this is the right way to go."
Baxter, the superintendent of elementary schools for the Archdiocese of Los Angeles, told OSV that the schools in his archdiocese are incorporating the Common Core elements that best complement their Catholic mission.
"We are not mandated to implement everything," Baxter said. "We take what we feel is valuable. Anything that we feel aren't good standards, we dismiss those."
Before Common Core, Baxter said the archdiocese's schools used California's state public school standards.
"Those were secular standards, but we took them and incorporated our faith throughout them," Baxter said. "We've been using state standards for more than 15 years. This is not something new or different."
Several Catholic school superintendents have told parents they are currently examining the Common Core, while others have decided against implementing the Core. In November 2013, Bishop David Ricken, head of the Green Bay, Wis., diocese, wrote a column in the diocesan newspaper, The Compass, announcing he had instructed his diocesan Department of Education to neither "adopt or adapt" the Common Core, but instead to use the Core as a reference point to improve the schools' current standards.
"The verdict is still very much out on the Common Core Standards," Bishop Ricken wrote. "All of the subject area standards have not yet been developed, let alone proved to be successful over time."
In the Diocese of Pittsburgh, which has been reviewing the Common Core, a group of parents created a Facebook page — Pittsburgh Catholics Against Common Core — and have communicated with other parent groups across the country to lobby against the Core.
"We're asking 'why embrace a set of standards that are not superior to our own Catholic standards?'" said Coleen Carignan, a member of Pittsburgh Catholics Against Common Core. "We're concerned this is going to institutionalize mediocrity in the Catholic schools when we've always had a solid record and a solid history to guide us." Carignan said she has one child in a Catholic school, which she said is supposed to be different from the public school system.
"An authentic Catholic education is supposed to begin with Christ, not as an add-on to secular standards," Carignan said.
Bob Laird, the programs director for the Cardinal Newman Society, an organization that promotes faithful Catholic education and Catholic identity on Catholic college campuses, told OSV that Catholic schools should base their standards on their Catholic identity instead of taking secular standards and trying to infuse them with Catholic terminology.
"We need to start with the basis of our Catholic faith and then build our curriculum around that," Laird said. "The mission of the Common Core is dramatically different than the mission of Catholic education."
Guernsey, the headmaster of the Rhodora J. Donahue Academy of Ave Maria, also told OSV that standards are derived from a school's mission, and curriculum is based on standards.
"Catholic school, Catholic standards, Catholic curriculum," Guernsey said.
More than 130 other Catholic scholars wrote a letter last October to the nation's bishops to urge them to either ignore the Common Core or stop its implementation. Sent by Gerard V. Bradley, a law professor at the University of Notre Dame, the letter called the Core "deeply flawed" and a "recipe for standardized workforce preparation" that reduces reading "to a servile activity."
Anthony Esolen, a Providence College literature professor who signed the letter, testified before a South Carolina legislative committee that the Common Core has a "cavalier contempt for great works of human art and thought." Esolen told the committee, "We are not programming machines. We are teaching children."
Sandra Stotsky, a professor emerita at the University of Arkansas, resigned from the Common Core Validation Committee over concerns about how the standards were written and their efficacy. In an address to the Conference on Catholic Concerns about the Common Core in New Jersey last November, Stotsky said the Core's ELA standards stress writing more than reading at every grade level, to the detriment of every other subject in the curriculum.
Stotsky also said the ELA standards require no British literature, aside from Shakespeare, or other classical writings from ancient Greece and Rome, or even stories from the Bible that would ensure a cultural fluency of Western Civilization.
"It's good that students learn how to read briefings and memorandums, but not at the expense of reading literature," Laird said. "In Catholic schools, you're reading the source documents, whether it's poetry, whether it's math. You're reading the source documents so students get not just a cursory overview, but also understand what it's all about."
Guernsey said "non-educators" crafted the Common Core ELA standards, which he said are based on assumptions that were not research-driven. Other critics also make the point that the Common Core has not been not sufficiently "field-tested."
"They're untested, and they are flawed," said Laird, who also criticized the Core's ELA standards for instilling a "valueless curriculum" where first-graders are asked to peer-review their classmates' papers.
Laird also criticized the Core's math standards for pushing algebra back to high school. He said delaying algebra and other mathematical disciplines to the higher grades may prevent some students from pursuing engineering, accounting and other math-based careers.
"This is a good opportunity for school districts, superintendents and Catholic schools to step back and say, 'Why are we really here?' and maybe go back, look at the entire curriculum and implement a more classical curriculum,'" Laird said.
Kathy P. Mears, executive director of elementary education for the National Catholic Educational Association, told OSV that the Common Core does not prevent teachers in Catholic schools from introducing literature to their students. She noted the Core's often criticized "Appendix B" of suggested readings and lesson plans is optional.
"The integration of faith, the arts, literature — it's all still there," Mears said, adding that the Core does not eliminate literature, but rather encourages teachers to be more "purposeful" in introducing nonfictional texts.
"When we talk about a balance, it doesn't mean that we're doing away with fiction," Mears said.
"The first thing that needs to be said is that classic literature is not diminished in our curriculum. Literature is still celebrated," Baxter said, adding that the increased focus on informational texts deals with the reality of what students' needs are.
"It doesn't diminish the value of literature, the classics, and the reading of literature for literature's sake," Baxter added.
The Common Core Catholic Identity Initiative — a national collaboration of Catholic universities, the NCEA, corporate sponsors and educators — assists Catholic schools in integrating elements of Catholic identity into the Common Core State Standards.
The CCCII website says the Common Core standards are "more evidence-based" than most previous standards, and that they are "relevant to the real world, focusing on the knowledge and skills students will need to succeed in life after high school, in both post-secondary education and a globally competitive workforce."
The Core's ELA standards also "draw on extensive scholarly research and evidence" while the math standards draw on conclusions from several studies of high-performing countries and states, according to the CCCII.
While saying that a "significant majority" of the Core's standards are "quite generic and non-offensive," Guernsey challenged the CCCII's claims, adding that the Core's drafters relied on assertions not supported by research or data.
"A Catholic curriculum should be based on the conviction that all truths ultimately converge in their source: God," Guernsey said. "This standard, among others, is sorely lacking in the Common Core."
Mears, who sits on the CCCII's board of directors, said Catholic schools should use their own standards if they find those to be superior to the Common Core.
"I think it's about being reflective, thoughtful and discerning about what's best for your children," Mears said. "Every diocese and every school gets to make that decision, and that might be the Common Core or it might not be."
Brian Fraga writes from Massachusetts.
Copyright © 1996-2014, Our Sunday Visitor, Inc. All rights reserved.


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Wednesday, December 26, 2012
Django Deconstructed
Good morning family. Last night, I saw Django Unchained. Check out my review below.
What did you think about Django Unchained? Please share your thoughts.
This article is cross-posted on Jack and Jill Politics.
11 comments:
- LadyglenDecember 26, 2012 at 12:16 AM
Awesome review. My thoughts exactly. Couldn't have said it better myself!ReplyDeleteReplies
Thank you, Ladyglen.Delete
I'll agree with the white savior comment but that's it. Had it been a black producer who made the film and the N word was used would you feel the same way? As far as the jokes used that's Classic Tarintino style he did it in Inglorious Basterds as well. I believe the topic of slavery is a difficult one and he exposed some facts about that time that we don't often see and no one has ever done. Did I cringe on some parts yes I did but I also know there was truth in those parts of the movie. The N word was used 103 times, I counted, it was first use about 45 min into the movie. Is the word offensive yes and that's history.Delete
Wonderful review, my brother! Thanks,and i love your video interaction. Makes your blog pop!Delete
When i saw a pic of Spike saying the film was disrespectful, that was enuf for me. For the life of me i don't get why we keep smelling the sour milk to see if it's sour. IJS
No enlightened black director would have used the N word as frequently as this movie. Even in Roots, they did not use the N word no where near as frequently Django. I found that to be replusive.Delete
Yes. I have seen Inglorious Basterds. I have seen many of Taratino's movies. Based on his past movies, I knew that he was the wrong person to direct a movie about slavery. Ain't a damn thing funny about slavery or the holocaust.
- AnonymousDecember 28, 2012 at 6:33 PM
I don't even agree with the white savior comment. Django saved himself and his wife. This is one movie where there was not a white savior.Delete
Did we see the same movie?ReplyDelete
I loved Django, and for once believe that this is a case where use of the N word is justified, because it's realistic. The jokes and the directors' fascination with mashing up genres (spaghetti westerns, blaxploitation, revenge fantasies, Blazing Saddles, etc) are what makes a movie about such an unpalatable subject accessible to the masses.
Good luck getting a critical mass of viewers to watch a *documentary* about slavery, much less a serious theatrical release. Like it or not, this kind of movie is what gets dialogue started across ages, races and points of view. And, it was done well, portrays noble black love in the face of the worst possible circumstances and features the title character as the true master of his destiny, as opposed to the fabled "white savior."Replies
- AnonymousDecember 28, 2012 at 6:35 PM
I agree with WritergrrlDelete
Thank you for your feedback. However, I disagree with some of your assertions. Django was not a master of his destiny. A white man freed him. A white man trained him. A white man helped him locate his wife. The so-called love story is just a backdrop. The love story took a back seat to the bloodbath and inappropriate humor.Delete
Furthermore, Roots was a serious TV series about slavery. It was a commercial success. Many movies about the Jewish holocaust have been successful. A quality film about slavery can be a financial success.
- AnonymousDecember 26, 2012 at 12:56 PM
Thanks for confirming why I won't giving one thin dime to support this mockery.ReplyDelete
Comedy and slavery in the same film? Seriously? Like, really???
Quentin Tarantino is a culture vulture who thinks he has a black card. He feels HE can tell our story better than we can, based on his comments about The Slave Narratives, which he feels do not address slavery as "truthfully" as his film does.
Really? Like, he feels he can tell the story better than the f_cking slaves themselves?
Yeahhhhh, he won't be getting MY money.


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Question: The Catholic Bible contains the Books of Maccabees, but the King James version does not. Why?
Answer: The original 1611 version of the King James Bible did have these, plus other disputed Old Testament books in it. Later, they were removed.
In addition to the issue related to the Books of Maccabees, there are a number of other omissions that make Protestant Bibles shorter. The following Old Testament books were deleted from Protestant Bibles: Tobit, Judith, Baruch, Wisdom, Sirach, 1 Maccabees and 2 Maccabees. There are also sections of the Book of Esther and Daniel that are omitted.
Why these differences exist is complex, but the central facts focus on ancient Christian tradition and the departure from this by Martin Luther.
The Fathers of the Church often referred to disputed books, and the Book of Sirach was widely used in the early Church as a first book of instruction for catechumens and converts to the Faith.
By the mid-fourth century, the Church settled on the definitive list of Sacred Scripture, which now included the New Testament books. Three Synods (or Councils) of Bishops at Carthage, Hippo and Rome largely settled debates about the New Testament books and also included the Old Testament list from the Septuagint, which contained the disputed books and passages the Protestant Bibles later removed. And thus, we see that the Bible emerging from antiquity is the Bible that Catholics still have today.
In the 16th century, Martin Luther removed a number of books from the Bible. He also wanted to remove New Testament books such as James and 1 Timothy and 2 Timothy, but they were left untouched.
But he did remove the books listed above largely because they supported a number of Catholic teachings that he rejected, such as praying for the dead, etc. He claimed that the Jewish bibles of his day did not contain most of these passages. And that is largely true. However, it is a serious matter that set aside 1,500 years of Christian tradition, rooted in apostolic authority, in favor of the opinions of Jewish rabbis of his time.
From this perspective, therefore, Protestant Bibles are deficient by failing to include significant sections of the Old Testament that nourished the Jewish people of Jesus' time and have been part of the Christian Bible for 2,000 years now.
Question: I overheard a Baptist coworker explaining to his wife that the pastor was requiring him to submit his W-2 form so that his tithe could be properly monitored. Is this right?
Answer: Tithing — that is, giving 10 percent of one's income to the church — is commendable and rooted in Scripture. But for a pastor to insist on tax documents seems far too intrusive. It is not something that would be tolerated in the Catholic Church.
Not only is the pastor intruding into private matters of a congregant, but it also manifests a lack of trust wherein a pastor ought to assume that a parishioner has discerned their proper level of giving with God. Accountability has its place, but intrusive investigations rooted in suspicion rather than trust seemed wholly out of place in any Christian denomination.
Msgr. Charles Pope is the pastor of Holy Comforter-St. Cyprian in Washington, D.C., and writes for the Archdiocese of Washington, D.C., blog at blog.adw.org. Send questions to Pastoral Answers, Our Sunday Visitor, 200 Noll Plaza, Huntington, IN 46750 or to firstname.lastname@example.com. Letters must be signed, but anonymity may be requested.
Copyright © 1996-2019 Our Sunday Visitor, Inc.


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Selecting your vehicle's make, model, and year allows us to display only parts and items specific to your car's model and year.
Part# G240155
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These Grade 8 bolts have the authentic center indent with the slots and come in the correct-length for both applications. This bolt head design prevents the fasteners from loosening due to vibration. 1963-68 water pumps have eight bolts, while 1969-77 have eleven bolts. Sold per each.


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Faster horses wrote:We always pick the female runt if possible. I don't know why.....they had to fight to get what they wanted, I guess, so would GRIT be the answer? We have had some fine dogs in the past. In the aggressive breeds like heelers, hanging tree dogs, etc. the females seem to be not-so-hard-headed. Anyway, that is what we have found. We have had only one male in the past 40-45 years and he was a nice dog, but that was about all. Didn't have much tough to him, and being blue-heeler Aussie cross, he was a bit hard headed. Mr. FH has a great way with dogs, so that helps a lot. He could control 3 working dogs and never raise his voice.
Good luck with your Hanging Tree pup! Lets see a picture when you get her/him.
Big Muddy rancher wrote:You can slow a dog down but a slow /lazy dog is hard to speed up
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- "No post on Sundays, no damn letters today —"
- —Vernon Dursley hopes for a reprieve from Harry Potter's Hogwarts acceptance letters due to the normal progression of the Muggle post system[src]
Muggle Mail was the general Wizarding term for the post system used by Muggles to send letters. Letters sent by this system generally required the presence of at least one stamp, a pre-paid form of postage. When Mrs Weasley sent a letter to the Dursleys, she was unfamiliar with the requirements regarding this and posted her letter with stamps covering every area on the envelope not used to write the addresses. A letter also needs an address to whom it is going to. While it is successful for Muggles, it isn't quite as convenient as its wizarding counterpart, owl post, which is able find an addressee regardless of their current location and only requires payment if the possessor does not own their own owl, barring special arrangements such as the owlery at Hogwarts School of Witchcraft and Wizardry. Post across international lines is also regulated by Customs.
In 1991, Harry Potter received his initial Hogwarts acceptance letter via Muggle Mail, but when the letter was taken from him by Vernon Dursley, the remainder were sent via owl post.
During Harry Potter's visit to The Burrow in the summer holidays of 1992, Arthur Weasley bombarded him with questions about aspects of Muggle life, such as plugs and the postal service (Muggle Mail).[1]
In 1995, Nymphadora Tonks sent a letter to the Dursleys informing them that they had been short-listed for the All-England Best-Kept Lawn competition. The fictitious competition was actually a ruse to get Harry out of the house so that the Advance Guard could spirit him away to 12 Grimmauld Place.
There is no post on Sundays, to the delight of Vernon Dursley, who incorrectly believed that this restriction would prevent the arrival of any more Hogwarts acceptance letters for Harry Potter on Sunday.
- Harry Potter and the Philosopher's Stone (First appearance)
- Harry Potter and the Philosopher's Stone (film)
- Harry Potter and the Chamber of Secrets (Mentioned only)
- Harry Potter and the Goblet of Fire
- Harry Potter and the Order of the Phoenix
Notes and references
- ↑ Harry Potter and the Chamber of Secrets, Chapter 4 (At Flourish and Blotts)


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Fluorophores targeted at specific intracellular organelles, such as the mitochondria, lysosomes, Golgi apparatus, and endoplasmic reticulum, are useful for monitoring a variety of biological processes in living cells using confocal and fluorescence microscopy. In general, organelle probes consist of a fluorochrome nucleus attached to a target-specific moiety that assists in localizing the fluorophore through covalent, electrostatic, hydrophobic or similar types of bonds. Many of the fluorescent probes designed for selecting organelles are able to permeate or sequester within the cell membrane (and therefore, are useful in living cells), while others must be installed using monoclonal antibodies with traditional immunocytochemistry techniques. In living cells, organelle probes are useful for investigating transport, respiration, mitosis, apoptosis, protein degradation, acidic compartments, and membrane phenomena. Cell impermeant fluorophore applications include nuclear functions, cytoskeletal structure, organelle detection, and probes for membrane integrity. In many cases, living cells that have been labeled with permeant probes can subsequently be fixed and counterstained with additional fluorophores in multicolor labeling experiments.
The culture of Indian Muntjac deer skin cells presented in the digital image above was labeled with MitoTracker Red CMXRos, Alexa Fluor 488 conjugated to phalloidin, and DAPI, targeting mitochondria, F-actin, and nuclear DNA, respectively. Often used in combination, these fluorophores are very popular for multi-labeling experiments to ascertain distribution of subcellular components in fixed and permeabilized cell cultures. Images were recorded in grayscale with a QImaging Retiga Fast-EXi camera system coupled to an Olympus BX-51 microscope equipped with bandpass emission fluorescence filter optical blocks provided by Omega Optical. During the processing stage, individual image channels were pseudocolored with RGB values corresponding to each of the fluorophore emission spectral profiles.
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EXCLUSIVE: HanWay boards RT Features thriller about 2010 favela siege.
HanWay Select has boarded sales on RT Features thriller Rio Siege, which is currently in post-production.
Based on true events, the film charts the story of five policemen who are caught deep undercover when the Brazilian military storm favela Alemao to flush out drug barons.
Jose Eduardo Belmonte directs a cast that includes Antonio Fagundes, Caua Reymond, Caio Blat, Gabriel Braga Nunes and Otavio Muller. The film is produced by Frances Ha and Night Moves producer Rodrigo Teixeira and is based on his original idea.
Teixeira, who took the project to HanWay with RT partner Lourenço Sant' Anna, said: "We're thrilled to be working with such a respected sales company as HanWay. It confirms our belief in the type of film we're making and evidences Brazil's new hotspot on the market. We're positive audiences will respond incredibly well to Rio Siege.
HanWay Select director of sales and distribution Fabien Westerhoff added: "HanWay teaming up with RT Features illustrates our push into foreign language genre films. This is the story of a few unknown heroes who participated in one of the greatest episodes in the fight against the drug trade and violence in Brazil's recent history."
HanWay is in Cannes with festival entries Only Lovers Left Alive, Seduced and Abandoned, A Story of Children and Film and Bernardo Bertolucci's The Last Emperor 3D.


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Howard Husock wrote a book review in the latest issue of City Journal discussing Wrestling with Moses: How Jane Jacobs Took on New York's Master Builder and Transformed the American City, by Anthony Flint, and Genius of Common Sense: Jane Jacobs and the Story of The Death and Life of Great American Cities, by Glenna Lang and Marjory Wunsch.
Jane Jacobs was the great self-taught urban philosopher and activist who wrote the Death and Life of Great American Cities, in which she took the lessons she learned from Greenwich Village to expound upon the value of organic urban life, where planning and government have a limited but instrumental role. This stood in direct contrast to the most powerful man in New York, the unelected Robert Moses, who built many of New York City's highways and housing projects.
Husock makes many notable points, including this one:
But good cases can make bad law, and the successful defense of Washington Square Park and the West Village can lead too easily to the conclusion that neighborhood preservation, by whatever means necessary, is always correct—and that opponents of development, by definition, occupy the moral high ground. Thanks partly to their efforts, New York City has not opened a new subway line since 1942, has no easy transit link to its airports, and enforces a system of legally dictated rents that allow affluent tenants to stay forever in cheap apartments and insulate themselves from neighborhood change. Some would even extend such rent controls to commercial properties, thus interrupting the cycle of decline and rebirth that marks dynamic cities.
Neither Moses nor Jacobs had a perfect philosophy. Any transportation advocate recognizes the need for eminent domain at some minimal level and that good transit can help organic growth. Think about how commercial and residential centers grow around particular subway stops or how other areas decay when city planners choose to move a bus line or close a light rail stop. In this day and age there is no such thing as truly organic transit. The days of paving over old walking and cow paths are over and transit now is a matter of government and the community working to make transit systems and routes that work with and for the community.
Moreover, Moses and Jacobs stand as historic examples of the long-lasting effects of making (or not making decisions in planning). Moses radically changed the city and Jacobs prevented some of his other attempts and set the tone to make sure that other Moses-like projects would never occur. In this day and age of 24-hour media we forget that our policy decisions have a longer lasting effect than the day or week they are put into place. A policy decision, especially one as large as where or whether to build a highway or subway can have ramifications for decades if not centuries.
As we finally begin to give transportation infrastructure its due in the 21st century, we are best served to remember that any decision on transit–whether it is high speed rail, improving our highways, investing in more subways, efficient cars or something else we are bound to imagine–those decisions do not solve only current problems. Those decisions will have ramifications today and for centuries to come. Transportation grants should not be handed out for efficiecy's sake or for mere stimulus effect, but to establish and preserve productive, creative, economically thriving centers of American life.


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My four-year-old and I spent a few happy hours last week designing, cutting out, and sewing up a monster for him. We had such a great time that I created a free mix-n-match felt monster PDF sewing pattern, which includes five different monster bodies, five different sets of eyes, five mouths, and five different accessories. (Keep reading to download the free pattern!)
Note: Find 20 beginner sewing projects here
It's a pretty cute line-up, right? But this is even cuter:
James is in love with his very own little monster, created using pieces he chose from the mix-n-match pattern as well as a little extra personalization. Younger kids, like James, can help trace their monsters, pick out eyes/mouth/accessories, hang out with you while you sew it up (and maybe even sit under the table and push the sewing machine pedal for you), and then help stuff the little guy.
Older kids could trace and cut their own monsters and pieces and maybe even glue the pieces on. It's a great interactive project.
The 8 page PDF pattern can be downloaded by clicking here. Just print it out and then cut out the monster and other pieces you'd like to use. Trace the pieces on felt, and you're ready to put your monster together.
Construction is so easy you probably don't need instructions, but here are some step-by-step photos, and I've added a few tips below.
Things to note: I used different colors of acrylic felt cut from a bolt at Joann's. I purchased 1/4 yard of each color, which came to $1.25 each at regular price, and I could have easily made three monsters from each 1/4 yard piece. Acrylic felt is cheap and comes in lots of colors, so it works well for this project, but it will pill as the monsters are played with and snuggled. Wool felt would hold up better, but it's much more expensive, so you can decide what works best for you.
This turquoise guy above is the easiest monster, so if you're new at sewing this might be where you'd want to start.
I sewed my monsters together so the seam allowance is visible on the outside – I think it gives a little sharper look and more definition to the small pieces (like horns and spiky hair). But if you don't like that look, just sew the front and back of the monster with right sides together, then turn it right side out before stuffing.
When sewing on eyes/mouth, etc., you can use either a straight stitch or a zig zag stitch. On the pink monster above I used a straight stitch, but on the yellow monster below I used a zig zig. I found that the zig zag was a little easier on circular objects, but a bit harder on objects with points (like the teeth). I think it looks fine either way.
I sewed everything on in matching thread, meaning I switched thread four or five times for each monster. However, I used a white bobbin on everyting but the grey/black pieces and it worked just fine. In fact, when I sewed the front and back pieces together I also used a white bobbin thread, and the back looks just fine – so I think you could probably get away with sewing all the pieces (except grey/black ones) with white thread – just use a straight stitch, not a zig zag, if you try this.
My apologies that this red guy looks so much like a little devil. I really didn't intend it – but when I cut him out in red and added the fangs and guitar he just got a little, well, devilish. My nine-year-old thought it was pretty darn cool, though…so maybe this monster will appear to older kids.
A few more things:
When you're sewing these up and you get to a point or a corner, leave your needle down through the fabric then lift your presser foot and turn the material to make a nice crisp corner. You'll probably need to do this a few times around some of the tighter curves as well. I sewed them all up with about a 1/4 inch or 3/8 inch seam allowance.
(That grey one is my favorite!)
Lastly, when stuffing you want to remember to stuff in a little at a time, and start by stuffing the small areas like arms and legs and use a pencil to poke the stuffing in nice and tight. You want to stuff these really firm, so use a lot of stuffing. When it's all stuffed up, squish the stuffing that's near your opening in very tight so you can pin the opening closed far enough away from the cut edge of the felt that it will fit under your presser foot. Be sure to backstitch at the beginning and end when you sew the opening closed.
When it's all sewn up, check the edges for any areas where the seam allowance looks a little sloppy and trim if needed to make it even.
I had a great time making all these monsters and my boys had fun helping – so I hope you enjoy the pattern. Please let me know if you try it out!


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Every year I say I'm not going to fuss with making Easter dresses, but every year one week before Easter I give in and make them anyway. I've been wanting new curtains in my bedroom, so I pulled a Scarlett O'hara, and used my old curtains to make my girls' dresses. So now anyone who wants a free peep show, come to my bedroom window. Kidding... no creepers please :)
Thursday, April 5, 2012
Easter Dresses 2012
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Labels: Easter Dresses, flower dress, handmade girls dress, sewing
3 comments:
- Janna said...
Miss Jodell...you've outdone yourself. The girls are beautiful and the dresses are amazing! Nice work. And get some new curtains soon...for the neighbors sake. ha ha
- April 5, 2012 at 3:06 PM
- Shivangi Sharma said...
Amazing stuff! The girls look so pretty & perfect in their dresses! Great DIY! And Happy Easter!
- April 6, 2012 at 1:27 AM
- Mens Suits said...
Amazing kids! I like their dress, perfect for Easter.
- April 10, 2012 at 11:29 PM
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Are you ready for Sethji???? What a fabulous book launch. I'd say, one of the best! That's my hottie editor, Chiki Sarkar, and our man in Mumbai, the dependable trouper Harish, with newbie Fiero at the back. We are wearing '' Í am NOT Sethji' caps .... you go figure the reference!
Pity Karnad rained on the parade, and dampened spirits. I was not aware of what Karnad had said during his session. All I heard hours later was that Karnad had converted his slot into a Naipaul bashing slugfest.Aah well.... every Lit Fest has its moments. The Karnad salvo marked this one.
More selfishly speaking.... I thoroughly enjoyed my session. Take a bow Anil Dharker! As for Jayant Kripalani.... what do I say? At short notice, Jayant read out chapter 33 from Sethji. It was a flawless , dramatised reading that gave the audience a rich flavour of the book.
I was still recovering from the amazing surprise party organised by my family the night before... more on that tomorrow....


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The Art of War
The Elves have had a long, and often bloody history of war and violence. Their conflicts with the greedy dwarves, bloodthirsty orcs, and ever expanding tides of humanity have been the fodder for thousands of Elvin epics. Yet in these tales, no great armies of elves take to the field to slaughter their foes. Being so long of life, the Elves reproduce slowly, and the thought of sending blocks of elvien conscripts to their death is anathema to them. Instead, the elves use a two-pronged method of warfare.
Vlos Mzil Abbanen
Not so much an artform so much as it is a political form. Literally 'the blood of many allies' this is the practice of employing mercenaries and faster breeding races as troops. Many times, human armies have marched against the foes of the elves as a common enemy. This can be by open alliance, with secrets and items exchanged, or it can be by deceit, manipulating the foes of the Elves into battling each other. Dwarves are simply hired from the elves caches of precious jewels and hoarded magic items. Even less populous races such as the giants, ogres, and even the rare tribe of goblins or orcs have found themselves the allies of the elves…willing or otherwise.
The radical group Via Humanitae has an expression, 'There is no more dangerous place than the side of the Elves'. This is a simple mix of anit-elven sentiment and a loose understanding of Vlos Mzil Abbanen, the Elven willingness to sacrifice their allies. Of course, the Elves will immortalize the fallen as footnotes in their thousand page epic poems.
Athiyk Lisse Killian
Athiyk is an ancient art, one that the elves have practiced since the begining. Literally the 'Harmonious Spirit of the Sword' this art is considered the core of elven fighting technique. Unlike their faster breeding, and shorter lived fellow races, the elves have lifetimes to hone their skills to supernatural levels.
Zotreth Drewst
The disarming strike, this is a basic attack that allows an elven swordmaster or speardancer to remove an opponent's weapon. The Drewst is only used when the foe is required to be captured alive, or when facing a more dangerous than usual foe who cannot be dispatched with ease. Elven archers use a variation of this, the Takrome Drewst where they use an arrow to disable a foe by shooting them in the weaponhand.
Zotreth Nizzre
The lunging strike, this is a penetrating attack delivered with the point of a sword, or with a spear. This attack was honed to defeat the non-armor defences of a foe, bypassing attempted blocks and parries with a lightning fast strike of the weapon. The Nizzre is often used in combination, following a block or parry with the weapon, flowing into the Lightning Strike.
Zotreth Khaliizi
The Khaliizi is one of the most devastating of Elven sword arts, a punishing attack that can sever limbs, remove heads and split shields with the force of the attack. Drawing upon the elemental strength of the trees and earth, the Elf anchors himself to the earth and strikes with all of his passion. This attack leaves the elf open for a counterattack, but only if his foe is still able to attack. Masters of the Khaliizi attack are the most brutal of elven warriors, willing to slip into the midsts of foes to hew them down like the farmer scything wheat. The spear variation of this attack doesnt sever limbs, but is often a killing strike that pierces the heart, or penetrates the brain through the throat.
Zotreth Zuddar
A basic strike, the Zuddar is a probing, testing strike that an elven master uses to test the ability of his foe. some elves will use this attack to slowly cut their foe to ribbons, weakening them with dozens of small wounds. most swordmaster instructors are masters of the Zuddar, and are best able to fight larger more powerful foes rather than large numbers of weaker foes.
Zotreth Rath
The Rath is a blocking attack, one used to literally attack a foes weapon. The Rath is used as an advanced form of blocking, often paired with the Nizzre counterstrike to deflect an attack and return it against their foe. Rath style masters often adopt positions as wardens or protectors of sacred places.
Zotreth Harventh
Masters of the cutting blade, Harventh style utilizes the slashing edge of the blade. Basic mastery of the Harventh style is mandatory for swordmasters, while masters of the Harventh style are able to give demonstrations of sword control and 'sword dancing' that leaves foes in awe of the elf's skill. Those who wish to fight are literally slashied to pieces by consistent, strong, and difficult to predict edge on attacks.
Zotreth Nacta
The Nacta is more often practiced by Elven Speardancers than the swordmasters. This art is centered around the weapon as a piercer of defences. The style is straight foreward, and almost utilitarian in its quick thurst method of killing. Nacta masters will use the basics of the Zuddar style to feel out a foe before delivering a coup de grace with a variety of Nacta wounding or killing strikes.
Unarmed combat
The Elves have long used unarmed martial arts in their competitions and in warfare. This comes from the most basic premise that no weapons other than hands and feet are required, and even unarmed, an elven warrior can be deadly.
Orbb Rah Laur
The basic skills of Orbb Rah Laur include a variety of submission holds, joint locks, joint breaks, as well as deflecting kicks and hand strikes. The heart of Orbb Rah Laur is emulation of the spider, who defeats the foe with a constricting and entangling web. Those who grapple with Orbb masters often end up literally in contorted knots.
Maelthra Rah Laur
Some consider Mealthra to be the most punishing of the elven martial arts, as it is centered around a variety of crippling punches and kicks. Facing a Maelthra master can quickly end in broken limbs, shattered joints, and death from a broken neck. To further emulate the rage filled Dragon, some Maelthra masters will learn fire magics and spells that allow them to inspire fear, or to fly.
Szeous Rah Laur
Also known as the Secret Art, a master of Szeous must first master Orbb and Maelthra as well as at least two of the Zotreth weapon styles. The Szeous masters are able to flow from one style to another with speed and grace that belies their incredible ability to deal out death and suffering. A Szeous master can also deliver supernatural strikes, such as blows that cause paralyzation, violent illness, and even death with the correct pressure points. A master can also deliver unarmed attacks as ranged attacks, striking at the air, but the foe feeling the full force of the hit, even a dozen feet away.
Other Arts
The Elves have had a long time to come up with other styles that have few if any contemporaries in the martial arsenals of the humans and other races. These are as unique as the masters who know and use them.
Luth Vinult
Luth masters are known for their thrown weapons, the most common being leaves from trees that have been hardened to steel strength for a few moments. some in more cold climes have adapted this art to throw similarly hardened pine needles like steel needles. Many of the Elven rangers and forestals are versed in the basics of this art, allowing them to turn leaves and needles into throwing weapons. Masters can turn a handful of oak leaves into shredding storm of death, and a pine branch into a weapon capable of blinding and maiming dozens of soldiers. A common weapon of the Luth master is the Roesor, a seed pod or bird egg that has been filled with smoking powder, poison dust, blinding dust, or a variety of other alchemical mixtures.
Draa Tyn Velve
This is one of the most physically demanding of the sword arts, as it uses the two bladed sword, a weapon that mounts two sword blades one a long handle. Using it requires both a good deal of physical strength as well as manual dexterity. Proper mastery of the Draa Tyn Velve is a blend of the Harventh slashing techniques, Rath blocking and weapon strike techniques and Nizzre counterattack techniques, yet does not fully embrace any of those styles completely.
Takrome Nautkyn
This is the storied art of elven archery, the martial skill of shooting arrows blind, trick shooting, as well as the ability to perform astounding called shots like the Takrome Drewst. Nautkyn is the basis of all other archery specialties and styles.
Takrome Mzil
THe art of the storm of arrows, Mzil masters specialize in very fast shooting, launching a veritable storm of feathered shafts when they attack. A master can fire over a dozen arrows in the time a human archer can fire three. Other specialties include shooting more than one arrow at a time, and firing multiple arrows that all hit at the same time.
Takrome Wlalth
The so called Arcane Archers, these bowmasters are able to lauch spells imbued into their arrows. Wlalth masters can decimate entire legions of soldiers with a barrage of ensorceled arrows, though even among the elves such masters are few and far between.
Velkyn Menvis
While it would be easy to lump the Velkyn Menvis in with the other minor arts, it would be wrong. Velkyn Menvis, or the Hidden Path, is the Elven art of Stealth and survival. This skill is taught almost from birth, the moving silently, and passing unseen. Elven nobles move with an innate grace that springs from this art, elven assassins slide from shadow to shadow, and rangers can move from dry branch to dry branch by using this skill. This art is seen in its highest form when combined with Szeous Rah Laur and Luth Vinult.
The Elves have been fighting for a long time, and their arts reflect a patient people capable of adaptation and facing foes who are consistantly numerically superior. While the term master has been bandied about many times in this sub, elven swordmasters, bowmasters, and speardancers are rare, as it takes decades to lifetimes to master the forms and positions and moves that compose a single style. The average elven warrior type will have comprehension of several styles, and basic mastery of one. There might be one master for every 2000 or 5000 regular elven warriors.
Much of this was heavily influenced by the real world martial art of Ninpo. Translations of the elven forms came from the House Maerdyn Drow translator.
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On Thursday afternoon, The Queen hosted her third garden party of the summer.
This time it was the turn of Hollywood to meet royalty, as actor Benedict Cumberbatch mingled with the royal family.
The Star Trek: Into Darkness actor was spotted chatting to Sophie, Countess of Wessex.
The stylish royal was attending the third party of the season, as the crowds took to the beautiful lawns of Buckingham Palace, which are only open to the public at these events.
Sophie, married to the Queen's son Prince Edward, has most recently increased her royal duties, and this was her second event in two days.
The Countess visited the Guildford Flower Festival on Wednesday as she spent a day in Surrey. Sophie arrived in a summery white dress where she was greeted by excited children.
Sophie, who has recently been announced as the first ever patron of London College of Fashion, has been praised for her warm nature, and in recent years has represented The Queen on many trips abroad. Last year, the Earl and Countess visited Gibraltar as part of the Diamond Jubilee celebrations where they were met with crowds of well-wishers.
The Countess enjoys a close relationship with her mother-in-law The Queen and the 86-year-monarch often pops into Edward and Sophie's home for a cup of tea.
The Queen will host a fourth garden party as the summer season continues.
Earlier this week, the Queen attended a coronation service with her family, which was attended by more than 20 members of the royal family, including the pregnant Duchess of Cambridge.


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I am 16 and know two people who have done self harm. Many people have misconceptions about self-harm and don't know the full truth. Many think they know.
Here are some common misconceptions about self-harm:
• Self harm is attention-seeking. In most cases this isn't true. Many keep their shameful secret to themselves to avoid judgment.
• Self-harm is an "emo" thing — emos are sensitive, artistic teens who share qualities with the goth culture and are prone to cutting. There is no typical self-harmer. They may look happy but inside they are suffering.
There are many more misconceptions surrounding this issue. The people who do this are no different from you. They are human beings who deserve love and support. This is an issue that affects many and is something from which they can recover.
Remember that words hurt more than punches.