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Before the father-and-son team behind BR Racing started tuning cars they raced. And, even now, when they're not tuning cars, they're either racing or instructing. For them, going to the karting track was an ideal way for father and son to spend quality time together. But it soon turned into an obsession when Robb Todd, the son, showed above average skills and the motivation to get better. Before long, the father, Bruce Todd, and son were spending their weekends towing their karts to races throughout the country.
Robb would end up being ranked in the top five in the nation as a 16-year-old in 1998, competing against the likes of Scott Speed and A.J. Allmendinger. Bruce, no slouch either, would go on to win or take poles in the Senior Sportsman, KT100 and 80cc Shifter class series. This is before the duo started racing an E36 and winning most of their class events.
They didn't plan on going into the business of tuning cars; rather, the business came to them. Fellow racers started asking the Todds to set up their cars because word had spread about their prowess with spring and damper rates and camber and caster settings. It got to the point where the neighbors started to complain about all the cars in front of the Todd house, forcing them to rent out a proper garage space.
In just a few short years, BR Racing has built a loyal clientele of both street and track enthusiasts in the San Jose/NorCal region, working on all kinds of European marques. We spotted their 135i at the Global Tuner Grand Prix at Laguna Seca last October (Global Tuner Grand Prix, Mar. '11). It was one of the most complete 1 Series we'd seen and it deserved a closer look.
The smaller, lighter 1 Series, especially the 135i, was supposed to be the second coming of the tii or the E30 M3. Although sales figures haven't shown that to be the case, they are nonetheless being raced and performing quite well. EAS (European Auto Source) and Evolution Racewerks, both based in SoCal, field competitive 135i's, with Evolution's 135i setting the lap record for its class at Willow Springs during the Redline Time Attack in 2010.
The Todds chose the 135i because it fit within the framework of what they were trying to do: build a daily driven street car that you could take to the track where it could hold its own against, if not beat, cars that cost much more. This, they like to point out, is different from making a track car suitable for the street.
BR Racing used the Global Tuner Grand Prix as a measuring stick, and they were quite satisfied with the results. Robb took the car to Fifth place in the Tuner class, behind the winning Dodge Viper ACR, a 997 GT3, a 996 GT2 and a lightweight 997 C2S, with his fastest lap less than a second off the Viper ACR's time, 1:37.604 versus Robb's 1:38.492. It handily outran a Novitec Rosso supercharged F430 Scuderia, a 997 GT3 RS, an EVO X and a Corvette Z06. You could say mission accomplished.
To accomplish said mission, they started by addressing some of the car's weak points. For extra power they gave it a Powerchips ECU tune and installed an ASR closed intake. They chose ASR's system because it offered the increased airflow and a true closed intake airstream. They also used an ASR-Tial blow-off valve and charge pipe. An Evolution Racewerks intercooler helps cooler air prevail while a BR Racing custom oil cooler, which sits behind the left front fender, helps keep the oil from boiling over. The exhaust system consists of AR Design catted downpipes, a custom center pipe and a Meisterschaft race exhaust. BR Racing said the mods are good for 420 hp to the crank.
One row through the gears is enough to convince you that 420 hp is about right. Like those model rockets you used to build and launch as a kid, this 135i will squirm and wiggle on takeoff before disappearing in the distance. Coupled with a shorter 3.46 rear diff and lighter-than-stock "flow formed" Apex Arc-8 wheels, the throttle response was more immediate than other modded N54 engines I've driven. It revved freely and didn't feel out of breath near redline. The turbo's torque was always within reach, and it only took a light nudge of the gas pedal to get into a lot of trouble.
Understeer was the other area the Todds felt needed to be corrected before the car would be competitive. They started by stuffing the widest front tires that would fit without rubbing the fenders. For the street they use Yokohoma S Drives, (245/40 front, 255/35 rear). And on the track they use two different sets, Dunlop Direzzas (225/40 front, 265/35 rear) and Hoosier R6 (225/40 front, 255/35 rear). When I drove it, the car was still on its Dunlops and the shocks were set for the track. In addition to wider tires, they installed front lower control arms and rear control arms from the M3, and also used M3 rear subframe bushings. The M3 front lower control arms gave it some needed negative camber but it still wasn't enough so they installed Vorshlag adjustable camber plates.
For the rest of the suspension, they chose AST's inverted-strut, coilovers up front and conventional coilovers in back. Three-way adjustable (two for compression, one for rebound) with external reservoirs, Bruce likes the AST system because it allows for a wider range of damping force through varying the amount of pressure in the external canisters. The car sat on Swift springs when I drove it but the Todds also use Hypercoil springs for other setups. UUC sway bars are connected to Ground Control adjustable endlinks. Although the shocks were set at 9 out of a scale of 12, the ride didn't rattle your teeth. It was undeniably firm but still daily drivable.
On the outside, the car uses a Vorsteiner vented carbon-fiber hood and a prototype Vorsteiner carbon-fiber front lip spoiler. That hood is kept tight by a pair of Aerocatch hood latches. BMW Performance carbon front grilles and trunk lip spoiler round out the subtle mods.
This 135i's combination of being small, light, firm and fast made it ideal for the B-roads outside of San Jose. It was quick to turn in, held its line tenaciously and never lacked for power out of the corners or down the straights, and it only felt like I was scratching the surface. If you were over-enthusiastic, the StopTech ST60 six-piston calipers and 355mm rotors in front and factory brakes in back easily got you out of trouble. Tightened up with a bolt-in rollcage, all of its movements were slack-free and instantaneous. Without question, BR Racing's objective of building a road car that can compete on the track was met. With the right changes, they managed to unleash the potential and slay some giants along the way. Their 135i straddles that fine line between road and race, and for many, that's exactly where they want to be.
BMW 135i
3.0-liter I6, dohc, 24-valve, turbocharged. ASR closed intake and BOV, Evolution Racewerks intercooler, BR Racing oil cooler, AR Design downpipe/catalysts, custom center pipe, Meisterschaft race exhaust, Powerchips ECU software
Six-speed manual, 3.46 rear differential
E92 M3 front lower control arms and rear control arms, Vorshlag camber plates, E92 M3 rear subframe bushings, AST coilovers, UUC antiroll bars, Ground Control adjustable endlinks
Wheels and Tires
Apex Arc-8, 18-inch, Dunlop Direzza, 225/40 (f), 265/35 (r)
Vorsteiner vented carbon-hood and carbon front lip spoiler, BMW Performance carbon grilles and trunk spoiler
Peak Power: 420 hp (BR Racing est.)


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The Lehman College Music Department is proud to present its 2011-12 Concert Series, including solo and chamber music recitals, and small and large ensemble concerts, featuring Lehman students, faculty, alumni, staff, and members of the surrounding communities. All performances are FREE and open to the public.
Please see below for a month-by-month concert listing, or click here for the full schedule. Click here for directions to Lehman.

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The annual Hay Days at the Humphrey History Park and Museum offered a little something for everyone on Saturday.
"The music has been the best part so far," Evergreen resident Leslie Scully said after sharing a dance with her husband, Steve.
The event, celebrating its third year, took attendees back to the early 1900s and showed what life in Evergreen was like then.
Buchanan Rec Center on Sunday morning was inundated with kids swimming, running and biking in a triathlon that was meant to simply be fun.
Nearly 130 children ages 5 to 13 swam laps in the pool, ran around one of the Bergen ponds, and biked through Bergen Park. No one timed the event, though lots of parents cheered, waved flags, rang cowbells and took pictures.
The workforce in Evergreen is made up of people who prepare food, repair worn shoes, develop social media skills for businesses and individuals, and manage nonprofit organizations that benefit the local and global community. They are among many people who help make Evergreen a thriving, viable place to live.
A restaurant family
Hla Win is a sushi chef with a fairly new restaurant in Bergen Park where he, his wife and son spend many hours preparing food and serving customers.
Several a-fungi-anados gathered at Flying J Ranch last Friday morning to learn about mushrooms in the mountain area of Jefferson County.
"We have between 2,000 and 3,000 mushroom species just in this area," said Mary Beth Carpenter, a volunteer with the Lookout Mountain Nature Center.
About a dozen people showed up for "Beyond Pizza: What Everyone Should Know About Mushrooms." Carpenter led the talk on families of fungus.
Rubber duckies quacked across the finish line in record time, buoyed by the fast-flowing waters of Bear Creek, in the fifth annual Dam Ducky Derby on Saturday.
The creek was flowing at 60 cubic feet per second, compared with its more sedate 20 cfs in previous Augusts, said John Ellis, an organizer and director of community relations at Evergreen National Bank. The first ducks crossed the finish line in less than half an hour.
Dogs and their owners in every shape and size participated in the fourth annual Wine, Washes & Wagging Tails event in downtown Evergreen on Sunday.
From tiny Chihuahuas to a 150-pound chocolate Lab, from young children to older adults, the benefit for the Evergreen Animal Protective League had something for everyone.
Bright and early on the Fourth of July, fine Americans from every walk, trot, gallop and dash of life put their feet to the street as Mount Evans Home Health Care & Hospice kicked off its 33rd annual Freedom Run 5K.
Evergreen resident Jack Holbrook had a typical work-from-home job — he talked with customers on the phone and worked on his computer for his job at the Electrical Construction Co. in Hawaii.
The problem was, Holbrook didn't really like working from his home. He went from working at a busy office in Hawaii to working at home in Evergreen, and he wanted to interact with co-workers. He also wanted to be able to meet with people and socialize after work.
Holbrook apparently is not alone.
"Gardens and flowers have a way of bringing people together."
— Clare Ansberry
No truer words could be written about the garden south of the Evergreen Metropolitan District on Highway 73.
Known as the dam garden, its blooms attract visitors from May to October while its maintenance brings Evergreen Garden Club members together every Friday morning.
Amateur astronomers were treated to views of Mars, Saturn and the International Space Station last Saturday at Staunton State Park.
Pam Little, astronomer and assistant director of the Evergreen Nature Center, led more than 20 attendees in a viewing of the night sky. Little handed out materials and showed everyone how to make a star clock.
The golf at Keys on the Green last Thursday was fairly normal — that is, if Santa Claus playing with a storm trooper could be considered par for the course.
More than 100 golfers decked out in crazy costumes used even crazier methods to compete in the Evergreen Rotary's 100 Holes of Golf fund-raising event.
Buffalo Bill was in Evergreen on June 11 to tell his story — dressed to the teeth in a light-tan buckskin jacket with fringe, knee-high black boots, a trimmed goatee and a cowboy hat.
Was it really THE Buffalo Bill Cody of Buffalo Bill's Wild West Show fame of the late 1800s?
Of course not.
It was truly the "Year of the Horse."
Saturday's Evergreen Rodeo Parade featured sawhorses on wheels made up to look like the real thing, and genuine equines that left behind plenty of all-too-real evidence of their attendance.
For John Steinle, director of the Hiwan Homestead Museum, the hobby horses presented their own challenges.
We'd like to know about interesting events or activities. E-mail items of 125 words or less to firstname.lastname@example.com. Items will appear on a space-available basis.
Chamber's Marketing Committee to meet
The Evergreen Area Chamber of Commerce's Marketing Committee will meet from 4 to 5 p.m. Wednesday, June 11, at the chamber office on Stagecoach Boulevard. If you are interested in joining, call 303-673-3412.
Bear Creek Dippers - Forest Hawks
Conifer High School senior Kooper Hackmann has been on a running kick lately.
Former Inter-Canyon fire chief David MacBean blames a lack of oversight and his own personal problems for stealing $647,000 from the district.
In an exclusive interview with the Courier, MacBean, who pleaded guilty in April to two counts of theft and one of embezzlement, also said the nominal stipend he received as chief led him to resent the job, and to use the district credit card "to surround myself with stuff."
He faces up to 27 years in prison at sentencing on June 24.
Kai Bianco is being called a "miracle baby" by Evergreen Fire/Rescue paramedics and Flight for Life personnel.
Kai, who turned 1 on Saturday, was bitten in the head by the family dog on March 4. Not only did he survive, but according to his parents, he's back to doing everything he was doing before the accident: pulling himself up to standing, babbling like babies do, and feeding himself.
Colorado Civil Air Patrol cadets in military uniforms and bright yellow vests were seen on Highway 73 on Saturday, searching for a hiker reported missing near Cub Creek Park in Evergreen.
Fortunately, the search-and-rescue effort was just a ground training exercise for some CAP members and cadets. The nonprofit group includes an Evergreen squadron and several teenage cadets.
The cloudy skies parted Saturday long enough for the first patriotic Field of Honor ceremony to take place at the Evergreen Elks Lodge.
Elks Lodge 2363, with the assistance of Evergreen's American Legion Post 2001, dedicated 60 flags honoring servicemen and women as a precursor to Memorial Day. The flags, which can be seen from Fireweed Drive, will be flown until June 8.
A few days after stocking ponds at Buchanan Park with 300 pounds of rainbow trout, members of Evergreen Trout Unlimited were teaching youngsters how to catch them.
From casting lines to tying flies, kids at the fishing camp were caught up in the learning curve on Saturday.
After reeling in a 17-inch trout earlier in the morning, 5-year-old Addison Kerper was among those watching Dr. Leonard Wheaton wind thread around a vise as he crafted a fly for trout.
Copyright © 2019
Canyon Courier is your source for local news, sports, events, and information in Evergreen, Colo, and the surrounding area.


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Border management
Fighting terrorism and transnational crime through effective border management.
Stolen and Lost Travel Documents database
INTERPOL's database of Stolen and Lost Travel Documents (SLTD) enables INTERPOL National Central Bureaus (NCBs) and other authorized law enforcement entities – such as immigration and border control officers – to ascertain the validity of a travel document (passports, identity documents, visas) in seconds.
The SLTD database was created in 2002, following the 11 September 2001 terrorist attacks in the USA, in order to help member countries secure their borders and protect their citizens from terrorists and other dangerous criminals using fraudulent travel documents.
How it works
Details of stolen and lost passports are submitted directly to the STLD database by INTERPOL NCBs and law enforcement agencies via INTERPOL's I-24/7 secure global police communication system. Only the country which issued a document can add it to the database.
Law enforcement officials at INTERPOL NCBs and other locations with access to INTERPOL's databases through the I-24/7 system – such as airports and border crossings – can query the passports of individuals travelling internationally against the SLTD, and immediately determine if the document has been reported as lost or stolen so they can take the necessary actions.
INTERPOL is not automatically notified of all passport thefts occurring worldwide, and the SLTD database is not connected to national lists of stolen or lost passports. As such, information on national statistics must be requested directly from the country in question.
Starting with a few thousand records from just 10 countries, the SLTD database has grown exponentially.
- 174 countries contribute to the database which contains more than 68 million records;
- From January to September 2016 it was searched more than 1,243,000,000 times, resulting in more than 115,000 positive responses, or 'hits'.
Extending access to SLTD
Despite the potential availability of the STLD database, not all countries systematically search the database to determine whether an individual is using a fraudulent passport.
In order to increase the use of the SLTD database worldwide, INTERPOL encourages each member country to extend access to the I-24/7 network – and through it access to its criminal databases including the STLD – to major airports, border crossings and other strategic locations. This requires the installation of technical equipment or specialized software.
To help identify and stop criminals from using lost or stolen travel documents long before they get to the airport or the border, INTERPOL has developed I-Checkit. This initiative allows trusted partners in the airline industry to submit travel documents for screening against the SLTD database when customers book a plane ticket.
A positive 'hit' will be relayed to law enforcement, to take any necessary actions.
Advice for travellers
Do not attempt to travel with a document that you have reported as lost or stolen.
Once you have declared your travel document as lost or stolen to your national authorities, it is cancelled and considered invalid. The details of the document are passed on to INTERPOL and entered into the SLTD database. Border officials in INTERPOL's member countries can screen passenger information directly against the SLTD database. Selected airlines can submit the document details through I-Checkit for screening.
If you try to travel with an invalid document, entry or boarding is denied. The travel document is seized to prevent its future use and you cannot travel.
View the travel safe infographic
Rwandan President meets with INTERPOL Chief as African Regional Conference concludes
Mauritania: Securing borders, building capacity
Fugitive investigations: enhancing interregional police cooperation
Counter-terrorism meeting addresses border security in East Africa
Japan funds project to boost transnational crime fighting in Laos
INTERPOL Chief accepts Peruvian award on behalf of Organization
An innovative tool to detect and prevent illicit transactions.
Advice for travellers
Do not attempt to travel using a document that you have reported as lost or stolen.


text: The Society of Folk, mystical Beings of Light from the 11th dimension, chose Aurial of Darluse Wood, a humble parchment maker in 7th century England, to visit their realm, pervaded with Pure Love. Aurial chronicles the wonders he experienced there and includes a message for Earth's future, our present day, about the potential for cataclysm and also Great Transformation. He warns that for mankind to survive, Love must survive in a world blind to its own suffering. Aurial sees the planet beset by the ignorance of her rude guests, flirting with killing our own environment. How will we respond? Will we outstay our welcome, push our planet too far? Will we enter into a feverish battle with Earth for survival, or experience a Great Shift in consciousness? The answers are within you.


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results for "kid", only Similar
displaying 1-30 out of 90
Kid on drugs
What happens when your kid comes out of the dentist and he is high because of the anaesthetic? You film it and you have a hilarious memory for years to come. Fantastic video and the little guy is awesome!!
Kid gets kicked in the face
That must have hurt!
Pale Kid Raps Fast
"Pale Kid" or else George Watsky in an insirational rap song, rapping fast!
Soldier and kid
I don't think you can call it funny, but it made me smile and I loved it. So here it is.
Dr. Dre as a kid!
Dr. Dre was always cool!
A little kid walks into a city bus and sits right behind the driver and starts yelling, "If my dad ...read the joke
8. Kid's letter to north pole comes back stamped, "Dream ...read the joke
Bad Kid's Homework
Are you a bad kid? Do your homework in this puzzle game!
Poor kid
That's an early start in rejections...
A small boy is sent to bed by his father.Five minutes later.... "Da-d....read the joke
The boss of a big company needed to call one of his employees about an urgent problem with one of ...read the joke
read the joke
Little Bobby came into the kitchen where his mother was making dinner. His birthday was coming up and he thought this was a good time to tell his mother what he wanted.


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The Wölfel group comprises two companies (engineering service and technology) with more than 60 employees, providing demanding solutions in vibrations and acoustics.
Create a realistic 3D computer model of the human body in order to design more comfortable car seats and examine the potential health effects of a wide variety of vibrations and loads on drivers and passengers.
CASMIR (Calculated Sitting Man in Research), a 3D human-body model, uses finite-element-analysis to assess seat designs.
Virtual prototyping has helped zero in on features, compare different designs, and rapidly optimize for both static and dynamic comfort. In addition, simulation has minimized the need for expensive prototypes and shorten the time to set up the model from several weeks to less than a day.


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The Materials Division undertakes cutting-edge research for advanced processing and performance of materials, enabling improved materials selection, lifetime management and support of emerging technologies.
News & Events
It's the little things that make Christmas special, and with this in mind, NPL has created the world's smallest Christmas card.
Mark Gee, Fellow at the National Physical Laboratory (NPL), discusses new ways to assess and reduce erosion from water impact in an article for Adjacent Open Access.
New high-temperature solid particle erosion test facility at NPL and the benefits it offers the aircraft industry featured in Aerospace Testing International magazine.
New apprenticeship standard for Metrology Technicians approved by government.
NPL has been awarded a new contract by Sharing in Growth UK Ltd to continue supporting the aerospace industry through its Product Verification Programme.
NPL has worked with Tech21 in an industry-first collaboration to deliver quality assurance.
The NPL Product Verification team has recently completed a successful Nadcap Gap Analysis with Aeromet International Ltd
Memorandum of Understanding signed between NPL and Imperial College London
Emeritus NPL Fellow, Bryan Roebuck, talks about his work in powder metallurgy on a Materials Today podcast
NPL has performed its first off-site X-ray residual stress measurement service for engineering company, Siemens
After many years under the Lifetime Management of Materials name, the National Corrosion Service returns to its original and more recognisable identity
NGF EUROPE Limited wins the Queen's Award for Enterprise in Innovation 2014, for its Glass Cord technology
NPL and the Science & Technology Facilities Council have signed a Memorandum of Understanding to enhance our knowledge of advanced materials
Investment in product verification to help supply chain profit: NPL wins £4.4 million contract as part of ambitious Sharing in Growth programme
NPL supports new Centres for Doctoral Training
EMRP project selected to organise international symposium in E-MRS
The European Materials Research Society (EMRS) Spring Meeting attracts over 2,000 scientists and engineers every year with a combination of technical and plenary sections and a large industrial exhibition. In 2011 there were more than 3,000 participants from 62 countries. Members of EMRP Thin Films, with support from EMRP TreND, applied for and were accepted to organise a full symposium in the EMRS Spring Meeting 2014.
Further information about the symposium
Measuring active catalyst area in fuel cells
A novel in situ diagnostic technique has been developed at NPL that makes possible for the first time monitoring of the active area of platinum catalyst in each individual cell in a polymer electrolyte membrane (PEM) fuel cell stack. This provides a powerful new tool for the study of critical degradation mechanisms such as catalyst poisoning, carbon support corrosion and catalyst sintering.
A joint paper by NPL and Johnson Matthey on this work has recently been accepted for publication in the Journal of Power Sources.
MEMS technology for energy harvesting
An article in leading publication New Electronics describes recent research from NPL - applying a new MEMS device for the in situ rapid evaluation of the piezoelectric properties of thin films or micro structured components, to MEMS energy harvesting technology.
The full article can be read in New Electronics
Improving MEMS commercial applications
First precise MEMS output measurement technique unveiled
Case Studies
NPL helped develop a 4-point bend test tailored to the needs of the oil and gas industry. This will enable the reliable evaluation of materials used for extracting and transporting oil from wells.
Warmer wetsuits
NPL has performed laboratory and field-based tests for UK wetsuit manufacturer, Spartan, to help further their knowledge of how wetsuits keep people warm.
Materials technology is vital to industrial competitiveness, energy security, sustainability and innovation across all sectors, including healthcare and the environment.
Underpinning future requirements is the need to develop novel materials with tailored properties, to make radical advances in materials processing, to optimise manufacturing and engineering through knowledge-based design, and to establish innovative tools for predicting and characterising performance.
The underlying challenge is to characterise processes at an increasingly localised scale to enable prediction and manipulation of macroscopic behaviour and the production of materials and systems with managed properties.
Advanced measurement techniques are being established at NPL (including 3D-t imaging, in-situ and on-line characterisation, and novel nano-probes), coupled with modelling to support developments in:
- Multi-functional materials, nanomaterials, fuel cells, electronic interconnects, organic electronics, organic photovoltaics and catalysis
- Composites materials for aerospace and wind turbines
- Coatings and surface engineered materials
- Lifetime prediction of materials for power engineering and oil and gas extraction in increasingly harsh environments.
Recent Publications
Feasibility of moisture and humidity determination using optical fibre sensing in polymer matrix composites. Lodeiro, M J, Young, T, Gower (2013)
Gradient WC-Co hardmetals : theory and practice . Konyashin, I*, Ries, B*, Lachmann, F*, Fry, A T(2013)
Plasma treatment as a method for functionalising and improving dispersion of carbon nanotubes in epoxy resins. Williams, J*, Broughton, W R, Koukoulas, T, Rahatekar, S S* (2013)
Processing of an ultrafine-grained titanium by high-pressure torsion: an evaluation of the wear properties with and without a TiN coating. Wang, C T*, Gao, N*, Gee, M G, Wood, R J K*, Langdon, T G*(2013)
Neutral and charged oxygen vacancies induce two-dimensional electron gas near SiO2/BaTiO3 interfaces. Kimmel, A V*, Iniguez, J*, Cain, M G, Sushko, P V*(2013)
In situ observation of crack growth in a WC-Co hardmetal and characterisation of crack growth morphologies by EBSD. Mingard, K P, Jones, H G, Gee, M G, Roebuck, B, Nunn, J W(2013)
Vertical comb drive actuator for the measurement of piezoelectric coefficients in small-scale systems. Wooldridge, J, Muniz-Piniella, A, Stewart, M, Shean, T A V, Weaver, P M, Cain, M G(2013)
Imaging size effects on the electrocatalytic activity of gold nanoparticles using scanning electrochemical microscopy. Wain, A J (2013)
Tribology testing of ultrafine-grained Ti processed by high-pressure torsion with subsequent coating. Wang, C T*, Gao, N*, Gee, M G, Wood, R J K*, Langdon, T G*(2013)
Good Practice Guides
Materials good practice guides aim to improve measurement understanding and technical abilities across the UK and the rest of the world. They describe good current practice and are produced with technical input from specialists in the particular subject covered.
Revealing the hidden microstructure of materials
Cool multiferroic materials for solid-state cooling
Innovations in Fuel Cell Metrology
Mapping photocurrent generation in the nanoscale
Measuring the condition and durability of structures
Nanofluidics: a study in choreography
Emerging technologies based on multiferroic materials
Electron Backscattering Diffraction
Please note that the information will not be divulged to third parties, or used without your permission


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Just a heads up here.. Code can not be pasted or typed into the entry box when useing Google Chrome (Beta).
Hi Malley, thanks for the heads up. Lets hope that it will work in the final version :)
If it works in Safari, it should also work in Chrome, they use the same layout engine, WebKit.
It realy has a glitches on pasting the code into compressor. It is possible to pase only after trying to resize textarea ;). But initialy it is impossible to paste. Maybe we should make a report to google? :)))
that is wierd...
' '
Any way, this app is very good!
Works for me, I don't know who fixed the issue (be it JSC or Google) but it does work now.
It must have been Google that has fixed the issue :)


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Vailima Letters/Chapter XXXV
MY DEAR COLVIN, - One page out of my picture book I must give you. Fine burning day; half past two P.M. We four begin to rouse up from reparatory slumbers, yawn, and groan, get a cup of tea, and miserably dress: we have had a party the day before, X'mas Day, with all the boys absent but one, and latterly two; we had cooked all day long, a cold dinner, and lo! at two our guests began to arrive, though dinner was not till six; they were sixteen, and fifteen slept the night and breakfasted. Conceive, then, how unwillingly we climb on our horses and start off in the hottest part of the afternoon to ride 4 and a half miles, attend a native feast in the gaol, and ride four and a half miles back. But there is no help for it. I am a sort of father of the political prisoners, and have CHARGE D'AMES in that riotously absurd establishment, Apia Gaol. The twenty-three (I think it is) chiefs act as under gaolers. The other day they told the Captain of an attempt to escape. One of the lesser political prisoners the other day effected a swift capture, while the Captain was trailing about with the warrant; the man came to see what was wanted; came, too, flanked by the former gaoler; my prisoner offers to show him the dark cell, shoves him in, and locks the door. 'Why do you do that?' cries the former gaoler. 'A warrant,' says he. Finally, the chiefs actually feed the soldiery who watch them!
The gaol is a wretched little building, containing a little room, and three cells, on each side of a central passage; it is surrounded by a fence of corrugated iron, and shows, over the top of that, only a gable end with the inscription O LE FALE PUIPUI. It is on the edge of the mangrove swamp, and is reached by a sort of causeway of turf. When we drew near, we saw the gates standing open and a prodigious crowd outside - I mean prodigious for Apia, perhaps a hundred and fifty people. The two sentries at the gate stood to arms passively, and there seemed to be a continuous circulation inside and out. The captain came to meet us; our boy, who had been sent ahead was there to take the horses; and we passed inside the court which was full of food, and rang continuously to the voice of the caller of gifts; I had to blush a little later when my own present came, and I heard my one pig and eight miserable pine-apples being counted out like guineas. In the four corners of the yard and along one wall, there are make-shift, dwarfish, Samoan houses or huts, which have been run up since Captain Wurmbrand came to accommodate the chiefs. Before that they were all crammed into the six cells, and locked in for the night, some of them with dysentery. They are wretched constructions enough, but sanctified by the presence of chiefs. We heard a man corrected loudly to-day for saying 'FALE' of one of them; 'MAOTA,' roared the highest chief present - 'palace.' About eighteen chiefs, gorgeously arrayed, stood up to greet us, and led us into one of these MAOTAS, where you may be sure we had to crouch, almost to kneel, to enter, and where a row of pretty girls occupied one side to make the ava (kava). The highest chief present was a magnificent man, as high chiefs usually are; I find I cannot describe him; his face is full of shrewdness and authority; his figure like Ajax; his name Auilua. He took the head of the building and put Belle on his right hand. Fanny was called first for the ava (kava). Our names were called in English style, the high-chief wife of Mr. St- (an unpronounceable something); Mrs. Straw, and the like. And when we went into the other house to eat, we found we were seated alternately with chiefs about the - table, I was about to say, but rather floor. Everything was to be done European style with a vengeance! We were the only whites present, except Wurmbrand, and still I had no suspicion of the truth. They began to take off their ulas (necklaces of scarlet seeds) and hang them about our necks; we politely resisted, and were told that the King (who had stopped off their SIVA) had sent down to the prison a message to the effect that he was to give a dinner to-morrow, and wished their second-hand ulas for it. Some of them were content; others not. There was a ring of anger in the boy's voice, as he told us we were to wear them past the King's house. Dinner over, I must say they are moderate eaters at a feast, we returned to the ava house; and then the curtain drew suddenly up upon the set scene. We took our seats, and Auilua began to give me a present, recapitulating each article as he gave it out, with some appropriate comment. He called me several times 'their only friend,' said they were all in slavery, had no money, and these things were all made by the hands of their families - nothing bought; he had one phrase, in which I heard his voice rise up to a note of triumph: 'This is a present from the poor prisoners to the rich man.' Thirteen pieces of tapa, some of them surprisingly fine, one I think unique; thirty fans of every shape and colour; a kava cup, etc., etc. At first Auilua conducted the business with weighty gravity; but before the end of the thirty fans, his comments began to be humorous. When it came to a little basket, he said: 'Here was a little basket for Tusitala to put sixpence in, when he could get hold of one' - with a delicious grimace. I answered as best as I was able through a miserable interpreter; and all the while, as I went on, I heard the crier outside in the court calling my gift of food, which I perceived was to be Gargantuan. I had brought but three boys with me. It was plain that they were wholly overpowered. We proposed to send for our gifts on the morrow; but no, said the interpreter, that would never do; they must go away to-day, Mulinuu must see my porters taking away the gifts, - 'make 'em jella,' quoth the interpreter. And I began to see the reason of this really splendid gift; one half, gratitude to me - one half, a wipe at the King.
And now, to introduce darker colours, you must know this visit of mine to the gaol was just a little bit risky; we had several causes for anxiety; it MIGHT have been put up, to connect with a Tamasese rising. Tusitala and his family would be good hostages. On the other hand, there were the Mulinuu people all about. We could see the anxiety of Captain Wurmbrand, no less anxious to have us go, than he had been to see us come; he was deadly white and plainly had a bad headache, in the noisy scene. Presently, the noise grew uproarious; there was a rush at the gate - a rush in, not a rush out - where the two sentries still stood passive; Auilua leaped from his place (it was then that I got the name of Ajax for him) and the next moment we heard his voice roaring and saw his mighty figure swaying to and fro in the hurly- burly. As the deuce would have it, we could not understand a word of what was going on. It might be nothing more than the ordinary 'grab racket' with which a feast commonly concludes; it might be something worse. We made what arrangements we could for my tapa, fans, etc., as well as for my five pigs, my masses of fish, taro, etc., and with great dignity, and ourselves laden with ulas and other decorations, passed between the sentries among the howling mob to our horses. All's well that ends well. Owing to Fanny and Belle, we had to walk; and, as Lloyd said, 'he had at last ridden in a circus.' The whole length of Apia we paced our triumphal progress, past the King's palace, past the German firm at Sogi - you can follow it on the map - amidst admiring exclamations of 'MAWAIA' - beautiful - it may be rendered 'O my! ain't they dandy' - until we turned up at last into our road as the dusk deepened into night. It was really exciting. And there is one thing sure: no such feast was ever made for a single family, and no such present ever given to a single white man. It is something to have been the hero of it. And whatever other ingredients there were, undoubtedly gratitude was present. As money value I have actually gained on the transaction!
Your note arrived; little profit, I must say. Scott has already put his nose in, in ST. IVES, sir; but his appearance is not yet complete; nothing is in that romance, except the story. I have to announce that I am off work, probably for six months. I must own that I have overworked bitterly - overworked - there, that's legible. My hand is a thing that was, and in the meanwhile so are my brains. And here, in the very midst, comes a plausible scheme to make Vailima pay, which will perhaps let me into considerable expense just when I don't want it. You know the vast cynicism of my view of affairs, and how readily and (as some people say) with how much gusto I take the darker view?
Why do you not send me Jerome K. Jerome's paper, and let me see THE EBB TIDE as a serial? It is always very important to see a thing in different presentments. I want every number. Politically we begin the new year with every expectation of a bust in 2 or 3 days, a bust which may spell destruction to Samoa. I have written to Baxter about his proposal.


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DELAND, Fla. (Feb. 5, 2010) - Coming off its most lopsided loss since joining the Atlantic Sun Conference in 2005-06, the ETSU women's basketball team looks to bounce back into the win column when the Lady Bucs face Stetson on Saturday afternoon. Tip is set for 3 p.m. inside the Edmunds Center.
ETSU (13-8, 11-2 in A-Sun) had its program-best nine-game winning streak snapped with its 92-55 loss at Florida Gulf Coast on Thursday night inside Alico Arena. With the loss, the Lady Bucs sit a game and a half back from the Eagles for first-place in the conference standings and now need some help from within the league in order to win at least a share of the A-Sun regular season crown.
The Lady Bucs allowed FGCU to shoot a program-best 63 percent from the floor, including 71 percent in a first half that saw the Eagles outscore the Lady Bucs 54-27. Senior Siarre Evans (Griffin, Ga.) recorded her 13th double-double of the season (12pts/12rebs); while TaRonda Wiles (Danville, Va.) scored a team-high 14 points.
Stetson is coming off a 70-61 loss against Campbell on Thursday night in DeLand. Ashli Jackson scored a team-high 18 points, including 4-of-7 from beyond the arc; however, the Hatters couldn't overcome 22 turnovers and being out-rebounded 42 to 31.
The Hatters were picked seventh by the coaches and sixth in the media poll, and Stetson currently sits 5-18, 5-9 on the season. Stetson has lost six of its last eight games; however, the Hatters have been without the services of three of their top four scorers over the last two games.
Fans unable to make the trip to DeLand can listen to all the action live, as "Voice of the Bucs" Jay Sandos will handle the play-by-play duties. Fans in Johnson City should tune into WKPT-AM (1590), WOPI-AM (1490) in Bristol, WKPT-AM (1400) in Kingsport. In addition, 94.3-FM in Kingsport, 97.9-FM in Bristol, and 97.7-FM in Johnson City will carry the game. Live video streaming is also available through ASun.TV and live stats will be offered through www.GoHatters.com.
For more information on Lady Buccaneer basketball, visit www.ETSUBucs.com.


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Former Arizona Congresswoman Gabrielle Giffords received some not so kind words from Connecticut state Rep. DebraLee Hovey.
According to Gawker, Giffords was told to "stay out of my towns", via a now-deleted Facebook post from Hovey.
Giffords was in Newtown, Conn. last Friday to meet with the families who lost loved ones in the tragic mass shooting that killed 26 people at Sandy Hook Elementary School. Her visit came just days before the two-year anniversary of the Tucson shooting that left her severely injured.
Hovey deemed Giffords' visit to be a political stunt. Amid criticism for her very public remarks, Hovey later apologized for her offensive comments towards Giffords.
She said she had hoped to regain a sense of privacy for the grieving families in her town and did not mean to attack the former Arizona congresswoman on a personal level.


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Chi's New Address Info:
Plot Summary: Chi is still living with the Yamada family, but they decide it isn't fair to force her to hide indoors in their "no pets allowed" apartment. So they decide there is only one thing is to be done, Chi must move away for her own happiness.
Genre: Comedy, slice of life


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Trevorbryant needed a new print or packaging design and created a contest on 99designs.
A winner was selected from 38 designs submitted by 9 freelance designers.
bb Productions
Exhibit and event designer for theme parks, museums, retail and restaurants
Young children attending a museum where the focus is on social responsibity and ethics.
The museum has in place a real ambulance that is less than inspiring in its use of graphics. The ambulance is an interactive exhibit, kids go inside and play roles of driver or paramedic. The ages of the children skew younger, toddler through age 8.
I am in search of a graphic design to be produced as a vinyl adhesive print, then applied to the existing ambulance, as in car advertising. The graphic must convey some sense of excitement but not danger. The following design elements are required:
1. The museum logo (see attached)
2. The word "ambulance"
Using the profile shot of the ambulance as a template, I'd like some suggestions for a fun and compelling design.


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Staff Monkeys
A Stockbrokers journey
Through the Global war on Terror
Staff Monkeys kept me chuckling at myself and all those that take themselves so seriously. What we do is serious business, but it has a humorous side. It took me down a hilariously accurate trip on Memory Lane and paid tribute to the grease that keeps the military machine sliding along. Peter Clark cleverly unlocks and exposes the secret weapon of the U.S. military: the indispensable Staff Monkey.
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In 2005, Peter Clark had been out the Army for 8 years and was making a good living working as a stockbroker. Clark kept his former co-workers at Smith-Barney posted with a constant stream of witty emails describing the human side of his adventures. Whether it's a roommate with an obsession to kill a rat that had moved into an attic, high maintenance General Officers or corrupt minor officials no one is safe from Peter's sense of humor.
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text:
dlmarta necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 72 diseños de 21 diseñadores freelance.
M33 Advisory
We are a new school business strategies and marketing firm. Basically, we go to various businesses and do a few things: re-brand them, create a plan for launching a product, clean up their books, find a merger partner, etc.
Our clients range from the Mom and Pop, to the Fortune 500. Most service firms like ours are very clean cut, Brooks Brothers, Wall Street type as it attracts the people who think they're the "elite". We are more humble, more fun, more creative, and all about our clients. Forget the elites! But we are elite, too.
M33 is a galaxy far, far away. Thus, perhaps I would like to convey a tommorrow, futuristic theme (stars, space, robots, etc.). I had dream the other night where "M 3 3" letters/numbers were in different, dark balloons n a 3-D type of picture, and in various shapes and sizes. And "Advisory" was written plainly below so it read M33 in balloons, and Advisory in normal font. Not saying you have to do this or I want this,, but thought it was kinda cool. ANyway, future is the theme.
Please be as creative as you can. I'm looking for fresh and unique, not today, but tomorrow. So please go for it, and you will win!
This is where the challenge really is. As stated, our target audience will vary from your typical Brick and Mortar restaurant, to the high tech software company ,to the conservative financial investment company. So the logo does have to be somewhat professional. However, I would still like it to differentiate us from the herd. I hate the herd! We are a startup and need to be different. Voodoo Donuts (http://voodoodoughnut.com) different. That brand, that kind of different.
3 different logos. Don't worry, the main logo should be really the hard work:
1. The Basic Logo alone
2. The Basic Logo (smaller) with our name spelled out: M33 Advisory
3. The Basic Logo (small) with our Name and Slogan spelled out
Slogan = The Next Era of Business
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Evan Zachary Stilts, a fifth grade student at Spencer County Elementary, served as a Page for Senator David Givens on Tuesday, Feb. 14. While in Frankfort he and his Pa, Harold Stilts, visited with Senator Givens in his office and toured the Capitol and the Capitol Annex. Evan is the son of Tabitha Tuck of Taylorsville, and Chris Stilts of Louisville, KY. He is the grandson of Harold and Patricia Stilts of Summer Shade, and Rocky and Dorcas Comito of Shepherdsville; and the great grandson of Mary Crumpton of Summer Shade and Marilyn Dickenson of Louisville.
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How do we manage revisions to GDP?
Gross Domestic Product (GDP) estimates are some of the most heavily requested and used data published on data.worldbank.org. And as many users notice, the estimates are sometimes revised, occasionally resulting in large changes from previously published values. Why do revisions happen, what information do we publish about those revisions, and where do you find it?


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|BareAll wheels of a passenger vehicle are on a bare road surface, some patches of snow, ice may be present.
|Partly CoveredTwo wheels of a passenger vehicle are on bare surface and the other two wheels are likely to be on loose snow, snow pack, or ice.
|CoveredAll wheels of a passenger vehicle are on loose snow, snow pack, or ice.
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ALBI, France (Reuters) - Team Sky locked up the mountain stages last year to help Bradley Wiggins win his maiden Tour de France title yet all the signs point to a different strategy this year with Chris Froome in charge.
This year's first mountain test comes on Saturday when the eighth stage takes the peloton from Castres to an uphill finish at Ax-3-Domaines with an out-of-category ascent to the Col de Pailheres in between.
Images of the men in black-and-blue setting a lung-burning pace in the climbs to prevent attacks in 2012 are still fresh, but things have changed since then.
Froome is a naturally aggressive rider and in Alberto Contador, Joaquim Rodriguez and Alejandro Valverde he will face a bunch of rival climbers who were not on the race last year.
Team Sky have anticipated that.
"When we were at the Vuelta last year, we thought with Chris that we would use the race to learn a lot of things," sports director Nicolas Portal said on Friday.
"It was not the same kind of route but we knew we'd see the same riders - Rodriguez, (Colombian Nairo) Quintana, Valverde - and we thought we'd have to be punchy, which is Chris and Richie's style.
"You always need to adjust your strategy in the final climbs. It depends on the route but also on your rivals. So it will not be like last year."
First, double Tour champion Contador of Spain is back after a one-year hiatus because of a doping suspension.
He suffered a crash in the opening week but seems to be fully fit as the Pyrenees loom.
"You don't know how the others are right now because there has been no tough finish yet," said Contador.
"We will see tomorrow. Tomorrow is the day when there could be some changes in the overall standings."
With all the climbers likely to lose ground on Froome in the time trials, aggression on the climbs is the only option for his rivals.
Froome, however, showed in the second stage that he was unlikely to stay on the wheels of his team mates when he briefly attacked the field in awe-inspiring fashion.
"I'm quite sure everyone's going to be attacking but I'm quite confident in the team I have. I feel in really good form at the moment," said Froome, runner-up behind Wiggins last year.
"It's going to be a fight being the first mountain-top finish, it's something."
Team Sky principal Dave Brailsford added: "I would imagine that for the first mountain-top finish, everyone's going to see where everyone else is.
"It will be aggressive, some of the racing this year has been much more aggressive than other seasons, and we've got some plans this year and I'm sure we'll be as aggressive as most," the Welshman warned.
"I think the time difference are more likely to be up Ax-3 Domaines, whereas there will be a downhill finish to Bagneres de Bigorre (on Sunday)," said Australian Cadel Evans, possibly the least attacking rider of all the top contenders.
There is a small question mark hanging over Andy Schleck's form in this Tour after the Luxembourg rider struggled for a year with a hip problem.
"Tomorrow I will know if I can aim at the GC (general classification). If I can't follow the best riders, I'll concentrate on a stage win or two," the 2010 Tour winner said.
Garmin-Sharp will see who fares best between American Andrew Talansky, Canadian Ryder Hesjedal and Irishman Dan Martin as they enter the mountains with an "open strategy", according to team manager Jonathan Vaughters.
Editing by Clare Fallon


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Julie Milanowski
Director of Business Development
Phone – 616-233-2580
Office Location: Grand Rapids Peter C. Cook Center
Prior to working at Davenport University, Julie worked for a corporate training organization for 15 years, where she provided training solutions to the insurance, manufacturing, paper and petro-chemical industries. In addition, she implemented new hire training, motivational training, and sales training to internal staff. She also has extensive experience implementing and utilizing DISC as a training tool.
Before joining IPEx at Davenport University, Julie worked as a successful admissions recruiter at DU. In her current role, Julie has helped numerous industries implement their corporate leadership, management, and development training for their employees in all facets of their jobs.
- 20 years experience providing training solutions to the Insurance, Government, Health Care, Manufacturing, Paper and Petro-Chemical industry
- Conducted new hire training for sales professionals including developing motivational training programs
- Extensive DISC training experience
Leadership Experience
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I think most of us have accepted the fact that one day robots will become so advanced that they'll take over the planet and enslave mankind. But until that day comes, we've still got a good five or six years when we can mock their feeble attempts to imitate humans. "Haha! Way to climb the stairs like you've got chronic back pain jerk-bot!" (High-fives another awesome human.)
In reality, though, this humanoid robot named Nao is demonstrating some fairly sophisticated image analysis and processing while it uses a laser scanner and built-in camera to carefully climb a spiral staircase all by itself. So watching ED-209 fall down the stairs in Robocop might have given us a false sense of security that robot attackers can be easily foiled by a staircase. Because they're obviously learning to slowly and painfully master that obstacle already. [Robots Dreams via Ubergizmo]


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glossy needed a new logo design and created a contest on 99designs.
A winner was selected from 69 designs submitted by 17 freelance designers.
We need to design a logo and the whole sticker (with the logo on it) for the bottle of olive oil.
See below
Cretan Olive Oil
Desired Color Scheme:
Desired Style:
stylish, modern
Accepted File Formats:
Vector Formats (.eps, .pdf or .ai); Layered Formats (.psd or .tiff)
I attach sample bottles scanned from another brand. The stickers should be same shape.
We need to design front and back stickers. The contents should be similar to the sample proviced.
There should be an emblem (like the trees in the sample) which will remind of the Cretan Sun, or the greek sky/sea etc. whichever you feel fits.
below that should say "Extra Virgin Cretan Olive Oil" or "Cretan Olive Oil" and below that "Extra Virgin".
The logo should be clean.
We think of using the orange color (because everyone uses the green). But we should show that it is olive oil (maybe use the olive oil leaves etc.).
Also, the crete map should stay (not the same with the sample's).
the rest should stay as in the sample. You can see the samples here:
Find out how a design contest works or learn more about our logo design services.


text:
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HCS combines rich and structured academics with extensive social/emotional programming to help all our students succeed in school and in life. We strive to develop scholars who seek knowledge, embrace effort, act thoughtfully, and commit to the common good.


text: American suffragist Alice Paul (1885-1977) was born into a prominent Quaker family in New Jersey. While attending a training school in England, she became active with the country's radical suffragists. After two years with the National American Woman Suffrage Association (NAWSA), she cofounded the Congressional Union and then formed the National Woman's party in 1916. Drawing on her experience, Paul led demonstrations and was subjected to imprisonment as she sought a voting amendment, but her actions helped bring about the passage of the 19th Amendment in 1920. Paul continued to push for equal rights and worked from National Woman's party headquarters in Washington, D.C., until her later years.


text:
We spent 2 days in Big Bend National Park - as we tailed the first day, we ventured on a short hike up Lost Mine trail, and since it was drizzling with huge storms a couple miles away, there was hardly anyone. It's so awesome to be able to not be in a rush, stop whenever you want to, read a brochure on the tree or a plant, learn something, touch something, smell everything...As we left the park for the day to our motel, we were treated to a full rainbow! It was going to be a great run-cation...
Thanksgiving Day came with big plans - to see everything (or as much as possible) in Big Bend proper in one big circle. We started at 8 am for a 21 mile journey and were amazed at how beautiful it is in the midst of a Texas desert. We hiked, walked, ran some, scaled an Emory peak (getting down that class 5 scramble is surely its own adventure, and when I climbed it up the wall, I heard Larry saying to some other hikers "I hate my wife" - what I took as a greatest compliment). The people were not too many, and those were friendly and thankful, as the day called for. We ended up running last downhill and making it sharp on 6 hrs, with enough time for a long drive through hell (where God threw up and spewed lava rocks around Earth) to St Elena canyon for a mile walk.
And so we walked, often slowly, stopping to admire the sudden Escarpment drops, talking, being silent and simply still. And thinking how my season of hard racing is behind me, and this is ok with me - this is finally, completely ok with me. How I love now so much more to be alone on the trails, and to be at my own will - and at my own pace. And yet how being trained for those very trail races allows me (us) to have these long back-country explorations, because who else could make 17 miles of rugged terrain in a daylight? I didn't want that day to end...but it did, 7 hrs later.
And so we were left with last morning before embarking on a long arduous drive home. Guadalupe Peak seemed to be fitting perfectly, and since we had scaled it years before (Larry - numerous times), and because our legs felt fresh and spring-y (a by-product of being an endurance runner who wakes up after many miles, or a side effect of a slow "recovery" day before?), we busted up and down with lots of pep for a quick turn-around (and before dozens of hikers began their journey up and a trail was crowded beyond pleasurable).
Full photoalbum of the trip
p.s. On a more boring and numbered side, I had run every day straight last week (after previous 2 weeks as well with only 2 days off) and managed 67 miles for the log! (which I should throw away by now). Must be my longest week this year (not accounting for the races). Who knows, may be it will help me crawl in Tennessee next month!


text:
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text:
SU5416 in Treating Patients With AIDS-Related Kaposi's Sarcoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00005042
Recruitment Status : Completed
First Posted : July 19, 2004
Last Update Posted : August 29, 2014
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: SU5416 may stop the growth of Kaposi's sarcoma by stopping blood flow to the tumor.
PURPOSE: Phase II trial to study the effectiveness of SU5416 in treating patients who have AIDS-related Kaposi's sarcoma.
|Condition or disease
|Drug: semaxanib
|Phase 2
OBJECTIVES: I. Determine the antitumor effects of SU5416 in patients with chemotherapy refractory cutaneous AIDS-related Kaposi's sarcoma. II. Determine the safety and tolerability of this regimen in these patients. III. Determine the pharmacokinetics of this regimen in these patients. IV. Determine the safety of this regimen on HIV replication and immune parameters in these patients. V. Determine the effects of this regimen on overall quality of life and tumor specific symptoms in these patients.
OUTLINE: This is a multicenter study. Patients receive SU5416 IV twice weekly for 4 weeks. Treatment continues for up to 1 year in the absence of disease progression or unacceptable toxicity. Quality of life is assessed. Patients are followed at 30 days after the last treatment, and every 3 months thereafter.
PROJECTED ACCRUAL: A total of 29 patients will be accrued for this study within 12 months.
|Study Type :
|Interventional (Clinical Trial)
|Primary Purpose:
|Official Title:
|A Multicenter, Open-Label, Phase II Study of SU5416 in Patients With Cutaneous AIDS-Related Kaposi's Sarcoma
|Study Start Date :
|January 2000
|Actual Primary Completion Date :
|November 2000
|Actual Study Completion Date :
|November 2000
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
DISEASE CHARACTERISTICS: Histologically proven, cutaneous AIDS-related Kaposi's sarcoma (KS) Must have failed at least 1 standard chemotherapy regimen for KS Chemotherapy refractory (progressed during anthracycline-based or paclitaxel therapy) OR Chemotherapy intolerant (hypersensitivity to drug or unacceptable toxicity) HIV positive At least 5 measurable cutaneous lesions No prior radiotherapy or intradermal therapy to indicator lesions OR KS-related generalized edema or edema of the extremities without evidence of active cutaneous lesions
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 50-100% Life expectancy: At least 3 months Hematopoietic: Absolute neutrophil count at least 500/mm3 Platelet count at least 50,000/mm3 Hepatic: AST no greater than 5.0 times upper limit of normal Bilirubin no greater than 2.0 mg/dL (no greater than 3.0 mg/dL if concurrent indinavir therapy) Renal: No history of renal failure Creatinine no greater than 1.8 mg/dL OR Creatinine clearance at least 60 mL/min Cardiovascular: No myocardial infarction within the past year No severe or unstable angina No history of unstable atherosclerotic coronary artery disease requiring coronary or peripheral artery bypass surgery within the past 2 years Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No known hypersensitivity to Cremophor or Cremophor based drug product No uncontrolled serious infection such as: Pneumocystis carinii pneumonia Toxoplasmic brain abscess CMV retinitis or colitis Cryptococcal meningitis Symptomatic Mycobacterium avium-intracellulare No other active malignancy, except: Basal cell skin cancer Carcinoma in situ of the cervix No cerebral bleed No diabetes mellitus with clinical evidence of severe peripheral vascular disease or diabetic ulcers No other acute or chronic medical or psychiatric condition that would preclude compliance No history of metabolic acidosis from nucleoside analogues Anion gap no greater than 11 (Na - Cl, HCO3)
PRIOR CONCURRENT THERAPY: Biologic therapy: At least 2 weeks since prior immunotherapy for AIDS-related KS and recovered At least 2 weeks since prior biologic therapy for AIDS-related KS No concurrent immunotherapy Chemotherapy: See Disease Characteristics At least 2 weeks since prior chemotherapy for AIDS-related KS and recovered No other concurrent systemic chemotherapy Endocrine therapy: At least 2 weeks since prior hormonal therapy for AIDS-related KS No concurrent hormonal therapy (including beta-HCG) Radiotherapy: See Disease Characteristics At least 2 weeks since prior radiotherapy and recovered No concurrent radiotherapy Surgery: At least 4 weeks since prior surgery No prior stereotactic surgery Other: Stable antiretroviral therapy for at least 4 weeks prior to and at least 29 days during the study Concurrent FDA approved antiretroviral agents or expanded access antiretroviral agents allowed At least 3 weeks since other prior investigational agents No concurrent local or topical therapy for AIDS-related KS No other concurrent investigational agents
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005042
|United States, California
|UCLA Clinical AIDS Research and Education (CARE) Center
|Los Angeles, California, United States, 90024
|United States, New York
|Memorial Sloan-Kettering Cancer Center
|New York, New York, United States, 10021
|Study Chair:
|Steven A. Miles, MD
|UCLA Clinical AIDS Research and Education (CARE) Center
|Responsible Party:
|AIDS Malignancy Consortium
|ClinicalTrials.gov Identifier:
|NCT00005042 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
CDR0000067633 ( Other Identifier: NCI )
|First Posted:
|July 19, 2004 Key Record Dates
|Last Update Posted:
|August 29, 2014
|Last Verified:
|August 2014
Keywords provided by AIDS Malignancy Consortium:
AIDS-related Kaposi sarcoma
recurrent Kaposi sarcoma
Additional relevant MeSH terms:
Sarcoma, Kaposi
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Neoplasms, Vascular Tissue
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


text:
4:00 pm
Curiosity Quest "Bakery" Join Joel as he visits Zingerman's Bakery in Michigan to learn how different types of bread are made. Watch as he helps create black cherry, chocolate bread and brownies at this world famous bakery. D
4:30 pm
Biz Kid$ "Understanding Your Paycheck" What's on your stub, bub? The Biz Kids use a modern American pay stub to explore various social movements of the last century. From unions to social security and from workman's compensation to the 401(k) plans of today-it's all there on the stub. Plus, you'll meet entrepreneurs and explore how they started their businesses. D
5:00 pm
Wishbone "Hercules Unleashed" This live-action program follows the exploits of Wishbone the dog and his human friends, Joe, David and Samantha through their adventures intheir hometown of Oakdale. Wishbone's everyday experiences trigger hi s imagination and he finds himself in scenes from classic works of literature. In this episode, as her dad reaches his 40th birthday, Samantha searches everywhere for the perfect present. D
5:30 pm
Cyberchase "Inside Hacker" It's the CyberSquad's most ingenious plan ever - and most dangerous! If they can insert a new memory chip into Hacker's H-Drive, they can turn him from evil to good. Once he's been shrunk and is inside Hacker, Matt's mission goes like clockwork until a force field is activated and envelops the H-Drive. All seems lost until Digit remembers a robot that Dr Marbles made that can break through any force field. D
6:00 pm
Martha's Sewing Room "Baby Puffing" Round yoke daygown embellished with baby puffing; Sew Quick, Sew Easy credit card case, Sew Easy Stabilizing segment on tips and tricks for stress-free embroidery; Heirloom Quilting with free-motion stitching. Guests: Connie Palmer, Kay Brooks, Nina McVeigh. D
6:30 pm
Best of the Joy of Painting "Pathway to Autumn" The excitement and splendor of fall is produced by Bob Ross' effective use of red, orange and brown tones. D
7:00 pm
Martha Stewart's Cooking School "Soups" Nothing comforts like a bowl of homemade soup; once you master a few basic techniques, you can make a host of variations. Watch as Martha makes a nourishing chicken soup that's as easy as poaching a chicken. Then learn the "flavor-boosting" techniques that go into making minestrone. D
7:30 pm
Chef John Besh's Family Table Sugar Snap Pea Salad with Pecans; Poached Eggs & Satsuma; Hollandaise over Crab Cakes; Fruit Salad with Champagne and Mint. D
8:00 pm
Hometime "Creekside Home Foundation" Dean, Miriam and the HOMETIME crew place and pour energy- saving insulated concrete forms for the new home foundation. D
8:30 pm
Rick Steves' Europe Classics "West Turkey" Rick visits the ancient sites of Ephesus and Aphrodisias, meanders up the Meander River, eats Turkish pizza and discovers a blend of ancient and modern cultures.G
9:00 pm
Burt Wolf: Travels & Traditions "Burt Wolf's Family Vacation" NULL
9:30 pm
Essential Pepin "Eggs-Quisite" Quiche With Bacon; Eggs Jeannette; Flan With Green Herbs; Spinach, Ham And Parmesan Souffle. D
10:00 pm
America's Test Kitchen from Cook's Illustrated "Ultimate Grilled Turkey Burgers" Test cook Becky Hays shows host Christopher Kimball how to make the best Juicy Grilled Turkey Burgers. Then, tasting expert Jack Bishop challenges Chris to a tasting of cheddar cheese. Next, gadget guru Lisa McManus reviews Oil Misters. D
10:30 pm
Moveable Feast with Fine Cooking "San Francisco, CA: Chefs Jeffrey Saad and Cortney Burns" Pete Evans travels south to San Francisco to cook a delightful international, spice-themed meal, as the chefs visit Tcho Chocolate Factory and Spice Ace to pick up fresh just-made chocolate and exotic spices such as galangal root. D
11:00 pm
Taste This! "Best Deli Sandwiches" When looking for the best kosher and non-kosher delis, remember to not only look in New York City, but also on Long Island. Keep an eye out because some establishments have placed a spin on original deli dishes. Chef Joe visits a famous kosher deli in NYC that is known for its homemade pastrami sandwiches with Cole slaw on the side. D
11:30 pm
Rick Steves' Europe Classics "West Turkey" Rick visits the ancient sites of Ephesus and Aphrodisias, meanders up the Meander River, eats Turkish pizza and discovers a blend of ancient and modern cultures.G


text:
Last time I related the results of the weekend's successful TomTom field test, and promised to post one of my historic site reviews for the destination. It was one of those Tennessee frontier museums that I'd intended to visit for a long time and had just never gotten around to seeing. I'm pleased to report that it exceeded my expectations.
Rocky Mount Museum is a historic house and farm in Piney Flats, up in Tennessee's history-saturated northeastern corner. The really surprising thing about the house is the fact that it's still there at all. William Cobb built it for his family in the early 1770's, when permanent settlement in what became Tennessee was still in its infancy. It's got to be one of the oldest homes in the entire state. It's also quite a substantial structure. If you're expecting a tiny frontier cabin, you're in for a surprise. The main house has a good-sized parlor, two upstairs bedrooms, a dining room across a covered dogtrot-style passageway, and an additional room converted into an office.
This office is one of the things that makes Rocky Mount so significant. After the State of Franklin dissolved in the late 1780's, North Carolina finally and permanently ceded its western lands to the Federal government. The area that's now Tennessee was organized into the Southwest Territory, with North Carolina's William Blount appointed governor. From his arrival in 1790 until 1792 (when he moved to a new frame house in Knoxville that's also become a nifty museum), Blount stayed with the Cobb family and conducted the territory's business out of the downstairs office. Rocky Mount was therefore the first capitol of the Southwest Territory, and Blount's time here figures significantly in the tours and programming.
There are several other buildings to see besides the main house. A detached kitchen, a smaller building that functions as a smokehouse and cloth-making area, and a slave cabin are also located on the grounds, along with a barn and livestock fields. It's a beautiful site with a gorgeous view; "Rocky Mount" wasn't just Cobb's creative nickname, because the house actually does sit on a high hill topped with rocky outcroppings.
The interpretive scheme relies heavily on first-person techniques and hands-on demonstration. Teams of costumed interpreters conduct groups through the buildings. All the guides working on the day we visited were extremely knowledgeable, not just about the site but about the Tennessee frontier and early American history in general.
In fact, the quality of the interpretation is one of Rocky Mount's greatest strengths. All too often I've found myself visiting a historic building and being led from room to room by a bored intern with the weary delivery style of a telemarketer. You won't find that here. Rocky Mount's guides are very engaging, and they know their stuff. Ask a question about the most minor object tucked away in a corner, and they'll not only identify it but also weave it into the larger story of life on the eighteenth-century frontier. Is it homemade? Yes, we make it out of such-and-such. Where do you get the materials? Well, this part comes from Mr. So-and-so's store in Jonesborough, and then we get that part in monthly shipments from Virginia.
And Mr. So-and-so's store, and all the rest of it, is actually documented. It's not so much a tour as it is a step into a fully realized, fully recreated world, all based on painstaking research. You get a sense of the household's place within a genuine, living frontier community.
This is living history in its fullest sense—not just clothes and personas, but actually doing the kinds of things necessary to keep a 1790's farm going. After seeing the house, we headed over to the kitchen, where a guide showed us how to bank the cooking fire to keep the coals smouldering while she explained techniques for preparing practically every food and medical remedy you'd find on an eighteenth-century plantation. Later, she took us past the garden, where we held the herbs up to our noses and smelled them, and then into an outbuilding to watch different kinds of fabrics being prepared, running them through our fingers to feel the difference. I've toured a lot of historic home sites, and I've seen a lot of first-person interpretation, but rarely have I seen any of this done so well.
I've also got to say that the way the buildings are stocked and furnished is incredibly convincing. Rocky Mount looks like a place where people live; if the Cobb family happened to show up, I imagine they could find everything they'd need to get by here. Because the tours are guided, there aren't barriers and cases all over the rooms to remind you that you're in an artificial environment.
A museum and orientation film offer an introduction to the history of the Tennessee frontier, from the French and Indian War to the early statehood period. Some of the exhibits are pretty dated, but they're in the process of being updated, and they're still worth a look, despite the wear and tear. As You'll be able to get an overview of the major events and personalities in early Tennessee history. (Seeing the powder kettle Mary Patton used to supply the King's Mountain expedition was a real treat for me, and one I wasn't expecting.)
There is one thing I found a little odd, and that's the selection of books for sale in the gift shop. There are quite a few hard-to-find titles on local and nineteenth-century Tennessee history, but many of the works on the frontier that you usually see in Tennessee museums aren't there. I was particularly surprised not to find a copy of Walter Durham's history of the Southwest Territory, which seems like such a natural fit. But this is a minor point, and I don't intend it as a criticism of the site's overall quality.
I'd enthusiastically recommend a visit to Rocky Mount Museum to anybody who's planning a trip through northeastern Tennessee. And if you're a Tennessean within driving distance of the Tri-Cities, you owe it to yourself to go. My only regret is that I didn't make it there sooner.


text:
Build an online store with the help of our team of mentors, and you could win one of four $50,000 seed investments.
Today we're excited to kick off our Shopify Build-A-Business Competition! To participate, all you have to do is open an online store and start selling products using Shopify. By February 28th 2013, the four stores that have sold the most over any two month period will win a grand prize package – including a $50,000 investment to help make your business an even bigger success.
We've brought on some of the industry's biggest names to act as mentors and help guide you through the process:
- Tim Ferriss, The 4-Hour Workweek
- Daymond John, Founder of FUBU & star of The Shark Tank
- Eric Ries, Author of The Lean Startup
- Tina Roth Eisenberg, swissmiss & Tattly
These world-renowned entrepreneurs have made it big through hard work, dedication, and savvy marketing skills. Now they're here to help you launch a successful online store. As a competitor, you'll get full access to advice from these incredible mentors through a competition 'dashboard' which will include exclusive videos, articles, and more.
Grand Prize Packages
- $50,000 investment from a mentor in exchange for 5%, valuing your company at $1 million
- Trip to New York City to meet with all the mentors
- $20,000 Google AdWords credit
- Feature article on Fast Company's website
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18 comments
July 10 2012, 10:05AM
This is awesome! I just signed up for Shopify, so I'm really excited about this competition.
July 10 2012, 10:29AM
Woah you guys rock!
July 10 2012, 10:51AM
So excited that this is launching today! This BuildaBiz buildup has actually been making me giddy. Can't wait to work with shop owners on this!!
July 10 2012, 12:10PM
great motivation and I like that you are focusing more on the mentorship aspect. Im tempted to start a second online store to compete.
July 10 2012, 12:32PM
July 10 2012, 05:09PM
Wow, definitely a generous offer!! Good luck to all the applicants..
July 10 2012, 07:33PM
This is exactly why I love Shopify and will never go back to Wordpress. Things like this just make you care and motivate you to do the best you can. I am so excited about this competition! Can't wait to work alongside with my mentor.
Thank you Shopify!
July 11 2012, 05:03AM
I love these competitions!
Its cool that Daymon John is in on this also! Daymon is also a Jay Abraham Student Fan!
Check out our store www.PortableSolarPower.Biz
July 11 2012, 05:14AM
Any reason why is it not open globally?
July 11 2012, 09:29AM
Does anybody know why these states are excluded… Total bummer.
"The competition is open to residents of the United States of America (excluding residents of Arizona, Maryland, Vermont, Delaware, Louisiana and Montana)"
July 11 2012, 09:43AM
Not open globally because every country, state, province has their own strict contest laws. It would be possible to open the contest around the world but it would cost literally tens of millions in legal and administration fees.
Same answer for States that are not allowed to participate.
Not sure I have an idea worth building a store around, but either way, great contest Shopiofy.
July 12 2012, 04:57PM
I'd love to participate in this but it says I'm not qualified. We started our store before March 1st because we were working on the back-end but we didn't go live or sell products until mid-end of April.
July 13 2012, 12:27AM
Why Dominican Republic and Its Currency (DOP) Its not available for Stores on Shopify?
If there is not problems with it, can you ask the Shopify Team to add this?
I want to enter the competition and meet Tim Ferris, but with this limitations I can't, Please Help!
July 18 2012, 10:04AM
Love this contest Shopify! Great job encouraging the entrepreneurial spirit and fostering it through a competition like this one.
Looking forward to seeing the progress of new stores.
By the way, for anyone who wants a quick and easy way to monitor your Shopify store analytics… check out this post (http://www.trendslide.com/blog/shopify-build-a-business-and-how-trendslide-can-help-you-win/), I think it could really help anyone participating in the competition.
July 18 2012, 05:42PM
Shopify's Dylan and others have already helped me w/ my new website www.fashionflexy.com. Ironically, I recently auditioned for & made it to 2nd round of "Shark Tank" auditions. The casting crew said Daymond will LOVE my charm slider invention for hair accessories w/ matching jewelry. Thanks for offering this contest, Shopify & Mentors!
December 02 2012, 08:08PM
Your system has been recommended to us………however,
I need to know what your cost/pricing structure is before we commit.
December 14 2012, 05:01PM
When does this contest end?
April 09 2013, 08:41AM
Today i came across this amazing new website named nupinch.com…i really think you guys should check it out..
Link: http://bit.ly/XczfI3