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Communities Net Premier community living featuring affordable to upscale living in planned active developments. Worldwide resource for active planned new home communities, rv/resort homes, golf course homes, vacation homes and luxury country club lifestyles. Communities Net is the most comprehensive resource of premier master planned communities throughout the world featuring site built homes, manufactured homes, waterfront living, gated communities, golf course home and more. See also: New Homes, Golf Course Homes, Mortgage Information, Pre-Owned Homes, Resales, Second Homes, New Home Buyers, For Sale By Owner, Country Club Living, Resort Living.
South Alabama is a term used to describe various parts of southern Alabama. Its usage does not however reflect a strictly defined geographic region. The most general description of the area would be all Alabama counties south of the Black Belt.
However, the largest population center of Mobile, Alabama, often makes the argument that South Alabama refers only to the extreme southernmost parts of Alabama. This is reflected in the name of the University of South Alabama, located in Mobile.
Following that usage, South Alabama is properly applied only to the two counties which border the Gulf of Mexico and Mobile Bay: Baldwin County and Mobile County. The area is characterized by extensive wetlands, but also by long, sandy beaches which are very conducive to tourism. Many deluxe golf courses have been developed in the area in recent decades.
News from the Mobile Press-Register
Saraland officials say afternoon thunderstorms ripped through a portion of city
Aug 9, 2014 7:56 pm
SARALAND, Alabama -- An afternoon of storms tore through a portion of Saraland Saturday leaving behind an unknown number of damaged buildings, an official with the ...
Saraland Police: Woman charged with pilfering antique coins, pellet rifle, tools and electronics while homeowner away
Aug 9, 2014 3:08 pm
SARALAND, Alabama -- One time wasn't enough for Linda K. Hamilton. The 43-year-old woman was arrested for burglarizing a tool shed last month, returning again to br...
Merrill 'upside down' over allegations in Alabama secretary of state race, McKinney argues
Jul 7, 2014 10:12 pm
Reese McKinney said he had nothing to do with his pay or budget during his tenure as Montgomery County probate judge. Insinuations to the contrary are wrong...
'I plan on blowing the aggregate limits out,' says Hoover man who challenged McCain-Feingold
Jul 7, 2014 6:44 pm
Shaun McCutcheon, an electrical engineer and contractor from Hoover who will address the Mobile County Republican Party this evening, said his message is si...
Congressman Byrne to meet with constituents this afternoon in Perdido Beach
Jul 7, 2014 11:13 am
It is the only constituent event Rep. Bradley Byrne plans this week. Congress will be in session the rest of the week, beginning Tuesday. ...
Thursday night Mobile-area weather: Partly cloudy tonight with plenty of sun over the weekend
Jun 19, 2014 9:45 pm
The National Weather Service forecasts a mostly sunny Friday with a high near 90 and a 30 percent chance of showers and thunderstorms, mainly after 1 p.m. ...
Convicted of sexually abusing young cousin and then fleeing the state, man gets 50 years
Jun 9, 2014 2:45 pm
Right before being sentenced for sexually abusing his 11-year-old cousin, Cedric Byrd continued to maintain his innocence. Vie...
Mobile's Wednesday night weather forecast: Calm low of 71
Jun 4, 2014 9:55 pm
MOBILE, Alabama-- The forecast for Wednesday night will be refreshingly calm without storms according to the forecast as it stands. The low looks to be around 71 wi...
Meet three bathing beauties and two other stars of 'The Greatest Show on Earth'
Jun 4, 2014 7:23 pm
Patty, Carol and Duchess weigh nearly 8,000 pounds apiece, making the elephants, literally, the biggest stars of the Ringling Bros. and Barnum & Bailey ...
Military blows up phosphorus flare found on beach in Gulf Shores
Jun 4, 2014 7:12 pm
Military personnel added some extra heat to the beach late Wednesday morning with the explosion of a phosphorus flare. View fu...
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subset: commoncrawl


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text:
Peyronie Disease
Some researchers believe Peyronie disease develops after an injury that causes bleeding inside the penis. This could explain cases of Peyronie that develop quickly. But it does not explain why most cases develop slowly, or what causes the disease after no clear injury.
Most researchers believe that genetics or the environment may play a role. Men with certain connective tissue disorders and men who have a close family member with Peyronie disease are at greater risk. And certain health conditions such as diabetes or tobacco use may also contribute to its development.
If the disease heals within a year or so, the plaque usually does not get worse. But when the disease lasts for years, the plaque often becomes a tough, fibrous tissue, and calcium deposits may form.
The plaque in Peyronie disease is not cancer.
The following are the most common symptoms of Peyronie disease:
- Changes in the way an erection looks:
- Plaque on the top of the shaft causes the penis to bend upward when erect. This is the most common condition.
- Plaques on the side causes the penis to bend to the side of the plaque.
- Plaque on the underside causes the penis to bend downward during erection.
- Plaque on both top and bottom or wraps around the penis, deformity, indentation, and shortening of the penis may occur.
- Painful erections
- Trouble with penetration
Pain, bending, and emotional distress can greatly affect the man's sex life.
The symptoms of Peyronie disease may look like other conditions or medical problems. Always talk with a healthcare provider for a diagnosis.
Your healthcare provider will review your medical and sexual history and do a physical exam, during which the plaque can usually be felt. Other tests may include:
- Ultrasound of the penis. An imaging technique that uses high-frequency sound waves to create pictures of the inside of the penis and check blood flow.
- X-ray of the penis. This may be done to get a better look at the plaque and check for tiny calcium deposits.
To check how the penis looks during an erection, medication may be injected into the penis to cause an erection in the clinic.
The goal of treatment is to reduce pain and keep you sexually active. There is no cure. Education about the disease and its usual course is often included in the treatment plan. In some cases, treatment is not needed. Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months. Treatment may include:
- Vitamin E. Small studies have reported improvements with oral vitamin E, but larger studies have not been done to prove that this treatment works. Still, this is an easy, low cost treatment choice.
- Various medicines. Many medicines taken by mouth have been tried, but none are proven to work in all men. If your healthcare provider wants to try medicine, be sure you understand what it is, what's known about it, and what side effects you should watch for.
- Injections of various medicines into the plaques. Injections of various medicines into the plaques have been tried in a small number of men, but none have been proven to work in large numbers of men.
- Surgery may be used to correct the plaque in severe cases, such as when the man has pain during an erection or can't keep an erection long enough to have sex.
Please talk with your healthcare provider with any questions or concerns you may have regarding this condition.
Peyronie disease affects each man differently. It can be very frustrating and affect your self-confidence in sexual relationships. It is not uncommon for men with Peyronie disease to have depression or relationship difficulties.
You and your partner should learn as much as you can about the disease
- Peyronie disease causes hard, flat plaque to form beneath the skin on the tissue of the penis. It causes pain and a sharp curve in the penis during erections.
- Some researchers believe Peyronie disease develops after injury that causes bleeding inside the penis, but most cases develop slowly, after no clear injury.
- Peyronie disease causes changes in the way an erection looks, pain when the penis is erect, and trouble with penetration.
- A physical exam (during which the plaque can usually be felt) may be all that's needed to diagnose Peyronie disease.
- The goal of treatment is to reduce pain and maintain sexual activity. In some cases, treatment is not needed. Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months.
- There is no cure for Peyronie disease. A wide variety of medicines may be tried. Most are taken by mouth, but some are injected into the plaque. In severe cases, surgery may be used to remove the plaque.
- Know the reason for your visit and what you want to happen.
- Before your visit, write down questions you want answered.
- Bring someone with you to help you ask questions and remember what your provider tells you.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
- Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
- Ask if your condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if you do not take the medicine or have the test or procedure.
- If you have a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your provider if you have questions.
January 16, 2018
Peyronie's disease: Diagnosis and medical management. UpToDate, Peyronie's Disease or Curved Penis: What You Should Know. Urology Care Foundation of The American Urological Association, AUA Guidelines Peyronie's Disease. American Urological Association
Reviewed By:
Greenstein, Marc, DO,Finke, Amy, RN, BSN


text:
Hey everyone, I have been a very delinquent blogger but you know how it is at times…. you just don't have the time!
I have been busy with exams, I have finals and I have been at school trying to tie up loose ends, prepare for exams as well as show my face at work and spend time with my daughter.. so my plate has been full.
I must pass these exams, they are essential to my career as well as my ability to provide for my daughter and myself. My next step is a Masters Degree.. but one thing at a time. First I must complete this Bachelors.
Tara is growing beautifully, she is saying new words like :'ish' for fish, 'buh' for bug, 'ba' for bike, and she calls trucks .. copter, and helicopters.. copter too. Just amazing, the terrible twos have started and man she can be terrible, she has started hitting, throwing things and screaming loudly and grabbing my clothes and hair when she is upset.
I tell her no, but she seems to continue…. how did you guys deal with this?
I am currently fighting the stigma that people have about single moms… why is it that people assume that single moms are trashy, careless women, who are uneducated and poor? That is not true, while there are some like that a lot of single moms like myself.. are classy, educated and ambitious women who are focused on raising our children to be happy, educated, healthy, well rounded individuals. Again, I encourage all single moms, to keep your head up! Be proud that you have not deserted your responsibility! Be proud that you work so hard for your kids, and be proud that while it hasn't worked out the way you wanted, you are doing the BEST YOU CAN and God will do the rest.
If you know of a single mom or single moms, don't treat her or her kid (s) like lesser beings, she is a mother too… …let us support each other, we are all in this thing called life together! Let us all strive to be kind and uplift each other and our kids… remember that:' being civil is the only thing that separates us from animals, well some of us'


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dearest is a valid word in this word list. For a definition, see the external dictionary links below.
The word "dearest" uses 7 letters: A D E E R S T.
Direct anagrams of dearest:
derates redates sedater
Words formed by adding one letter before or after dearest (in bold), or to adeerst in any order:
b - breasted debaters e - reseated f - draftees g - restaged h - headrest i - readiest seriated steadier k - streaked l - desalter reslated treadles m - mastered streamed p - pederast predates repasted trapesed r - arrested retreads serrated treaders s - asserted t - restated retasted w - dewaters tarweeds y - estrayed
Shorter words found within dearest:
ad ads ae aedes ar are ares arete aretes ars arse art arts as aster at ate ates dare dares dart darts date dater daters dates de dear dears dee deer deers dees deet deets derat derate derats dere desert deter deters drat drats dree drees drest ear eared ears ease eased east easter eat eater eaters eats ed eds er era eras erase erased ere ers erst es ester et eta etas rad rads ras rase rased rat rate rated rates rats re read reads red redate rede redes reds ree reed reeds rees reest res reseat reseda reset rest rested ret rete rets sad sade sae sard saree sat sate sated sea sear seared seat seated seater sedate seder see seed seer ser sera sere sered set seta setae stade star stare stared stead steed steer stere ta tad tads tae tar tare tared tares tars tas tea tear teared tears teas tease teased teaser ted teds tee teed tees terse trad trade trades tread treads tree treed trees tsade tsar
List shorter words within dearest, sorted by length
Words formed from any letters in dearest, plus an optional blank or existing letter
Try a search for dearest in these online resources (some words may not be found):
Wiktionary - OneLook Dictionaries - Merriam-Webster - Google Search
Each search will normally open in a new window.
List all words starting with dearest, words containing dearest or words ending with dearest
All words formed from dearest by changing one letter
Other words with the same letter pairs: de ea ar re es st
Browse words starting with dearest by next letter
Previous word in list: dearer
Next word in list: dearie
Some random words: tux jiao on eke wed eclair etoile
This is not a dictionary, it's a word game wordfinder.
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What was once meant to be a simple diversion while waiting in line, or something to keep the kiddies quiet, has now gained relevance in the tech/gaming world.
Tons of money and creativity have gone into the production of some fantastic mobile apps, which, to be honest, rival pretty much any game console on the market. In fact, heavyweights such as EA Games and others are developing experiences specifically for the mobile user. Plenty of homes have Xbox 360s, Playstation 3s, and Nintendo Wiis, but even more people carry cell phones in their pockets, and the number of tablet owners is growing, as the masses abandon their beloved PCs for portability.
A game can be as complex as the popular "Infinity Blade" series, or as simple as "Angry Birds." Priced at $.99 a pop, the series has become a favorite (spanning generations), and has even sprung up at retail stores in the guise of plush colorful stuffed toys and more.
Not content to just settle with an already massively successful brand, Rovio Entertainment is cooking up a whole new way to play "Angry Birds." First, there was "Angry Birds Space." Now, there's the highly anticipated "Angry Birds Star Wars," which is scheduled for release on Nov. 8. It's almost a given that the title (like its predecessors) is going to be a major hit. I'd wager that it'll do double the expected business given the "Star Wars" connection, and George Lucas wouldn't have lent his precious "Star Wars" universe if this game wasn't going to bring the awesome.
Obviously, there's more to come. This past summer saw mobile game versions of the movies "The Amazing Spider-Man," "The Avengers," and "The Dark Knight Rises." The graphics were top-notch and the price ($6.99) is a lot cheaper than the average $50 for a new game purchased from your local Best Buy or Game Stop.
Also, the ways we experience mobile games are changing.
The MOGA game controller is taking the idea further by giving the user a full-featured controller with dual analog sticks, shoulder triggers, and action buttons to get the job done. Touch screen gaming can be awkward, if not sometimes inaccurate, particularly for games with multiple control gestures, which can be frustrating to execute.
There's plenty to improve upon, but mobile gaming is moving past its infancy and into a larger world populated by grownups.
What's clear is that mobile games are here to stay. More importantly, they're constantly evolving into more than time-wasters, nostalgia trips, or remakes – it's an art form with a wide landscape ready to be populated.
Click here to watch "Angry Birds Star Wars" trailer


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The 2008 Catalyst Awards Dinner, sponsored by Shell Oil Company, was held on Wednesday, April 9, 2008, at The Waldorf Astoria in New York.
2008 Catalyst Awards Dinner
Catalyst Event
9 April 2008
Price: Free
More than 90 CEOs joined Catalyst to honor Award-winning initiatives to advance women from ING U.S. Financial Services (USFS) and Nissan Motor Co., Ltd. Serving as Dinner Chair was Kenneth I. Chenault, Chairman & CEO, American Express Company.
ING U.S. Financial Services
ING USFS' initiative, Beyond Diversity: Building One ING Culture, has created a unifying culture that identifies diversity and inclusion as a business imperative, increased women managers at the top-most level, and has become a model for the global organization. In 2001, recognizing the need for change, the company used a transition period of rapid acquisitions and subsequent consolidation to identify the necessary levers for culture change. ING USFS then capitalized on different talents, perspectives, and ideas to increase diversity and inclusion across all of its business locations. The resulting "One ING" culture benefits all employees, with a strategic focus to include women and other diverse groups.
Since the initiative's inception in 2003, ING USFS has increased women's representation on the senior management team from 25 percent to 50 percent, and currently, two executive women in profit-and-loss roles manage 80 percent of ING USFS business. Two out of three people in the succession pipeline to CEO are women, and the percentage of women in people-manager positions has increased from 45.7 percent in 2003 to 47.9 percent in 2007.
Nissan Motor Co., Ltd.
Nissan Motor's Japan-only initiative, Women in the Driver's Seat: Gender Diversity as a Lever in Japan, uses diversity to secure business success by increasing women's participation and contribution in all areas of the business. The business case for having women as decision-makers and in positions of influence within the company was developed in response to research identifying women as influencers of two-thirds of all car purchases. With the support of many senior leaders and champions, the resulting diversity strategy focuses on three areas: engagement, education, and advancement of women.
The initiative showcases solid increases for women in positions of influence in Japan. Since 2004, representation of women in management positions has increased from 2 percent (36 women) to 4 percent (101 women). The percentage of women managers in the design, planning, and product planning function has doubled from 4 percent to 8 percent. In the pipeline to management, women assistant managers have increased from 2 percent to 4 percent and women team leaders from 4 percent to 7 percent. The percentage of salespeople (Car Life Advisors) at Nissan-owned dealerships who are women has increased from 4 percent to 6 percent, while the percentage of women in manufacturing plants more than doubled.
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IBM Corporation
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ITT Corporation
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Microsoft Corporation
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Pricewaterhouse- Coopers LLP
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Sara Lee Corporation
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Wal-Mart Stores, Inc.
Weil, Gotshal & Manges LLP
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Xerox Corporation
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BDO Seidman, LLP
Bechtel Corporation
Bell Canada
Squibb Company
Cablevision Systems Corporation
Colgate-Palmolive Company
Continental Airlines
Davis Polk & Wardwell
Debevoise & Plimpton LLP
Electronic Data Systems Corporation
Enterprise Rent-A-Car Company
Fluor Corporation
Gannett Co., Inc.
Genworth Financial, Inc.
Georgia-Pacific LLC
Goodwin Procter LLP
Grant Thornton LLP
Interpublic Group
J. C. Penney Company, Inc.
Johnson & Johnson
Chase & Co.
Kaye Scholer LLP
International, Inc.
McKinsey & Company
Merck & Co., Inc.
Morrison & Foerster LLP
Northwestern Mutual Foundation
NYSE Euronext, Inc.
Ogilvy & Mather Worldwide
Paul, Hastings, Janofsky & Walker LLP
Pillsbury Winthrop Shaw Pittman LLP
Prudential Financial, Inc.
RR Donnelley
Society for Human Resource Management
Staples, Inc.
Sunoco, Inc.
TD Bank Financial Group
Terex Corporation
Unisys Corporation
U.S. Bancorp Vinson & Elkins L.L.P.
ABM Industries Incorporated
American Institute of Certified Public Accountants
Angela V. Shaw
Arvin Meritor
Beth Horowitz
Delta Air Lines, Inc.
Eastman Chemical Company
Eastman Kodak Company
EMC Corporation
Enbridge Inc.
FPL Group, Inc.
The Hertz Corporation
Lend Lease Corporation Limited
Lockheed Martin Corporation
McCarter & English, LLP
McKinsey & Company (Canada)
MENTTIUM ® Corporation
Nissan Motor Co., Ltd.
Principal Financial Group, Inc.
RSM McGladrey, Inc.
SBLI USA Mutual
Life Insurance Company, Inc.
Sears Holdings Corporation
Simpson Thacher & Bartlett LLP
Sprint Nextel Corporation
Starcom MediaVest
Weyerhaeuser Company
The Williams Capital Group, L.P.


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Hat: Urban Outfitters
Dress: Forever 21
Socks: Madwell
Shoes: Deena and Ozzy @ Urban Outiftters
Cute sketches, Victoria!
Ha! Such an adorable idea! I love it!
Cutest outfit eevvver! :)
cute idea you've picked up!! love the pattern on the dress and the facial expression ;)
Soooooooooo cute! I love the dress so much, and the socks make it 10 times cuter :)


text:
RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01217411
Recruitment Status : Terminated (Slow accrual coupled with discontinuation of study drug.)
First Posted : October 8, 2010
Results First Posted : February 6, 2015
Last Update Posted : February 6, 2015
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Estrogen Receptor-negative Breast Cancer Extensive Stage Small Cell Lung Cancer HER2-negative Breast Cancer HER2-positive Breast Cancer Male Breast Cancer Recurrent Breast Cancer Recurrent Melanoma Recurrent Non-small Cell Lung Cancer Recurrent Small Cell Lung Cancer Stage IV Breast Cancer Stage IV Melanoma Stage IV Non-small Cell Lung Cancer Tumors Metastatic to Brain Unspecified Adult Solid Tumor, Protocol Specific
|Drug: Gamma-secretase/Notch signalling pathway inhibitor RO4929097 Radiation: Whole-brain radiation therapy (WBRT) Radiation: Stereotactic radiosurgery (SRS) Procedure: Cognitive assessment Other: Laboratory biomarker analysis
|Phase 1 Phase 2
Show Detailed Description
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|5 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Two Phase I Studies in Patients With Brain Metastases From Any Primary Histology, Followed by a Randomized Phase 2 Study of RO4929097 Combined With CNS Radiotherapy in Patients With Brain Metastases From Breast Cancer Whose Tumors Are Estrogen Receptor Negative
|Study Start Date :
|October 2010
|Actual Primary Completion Date :
|November 2011
|Actual Study Completion Date :
|November 2011
Active Comparator: Arm I (WBRT or SRS)
Patients with >= 4 brain lesions undergo WBRT as in phase I and patients with =< 3 brain lesions undergo SRS as in phase I.
Radiation: Whole-brain radiation therapy (WBRT)
Undergo WBRT
Other Names:
Radiation: Stereotactic radiosurgery (SRS)
Undergo SRS
Procedure: Cognitive assessment
Ancillary studies
Other: Laboratory biomarker analysis
Correlative studies
Experimental: Arm II (WBRT or SRS and RO4929097)
Patients with >= 4 brain lesions receive RO4929097 and undergo WBRT as in phase I and patients with =< 3 brain lesions receive RO4929097 and undergo SRS as in phase I.
Drug: Gamma-secretase/Notch signalling pathway inhibitor RO4929097
Given PO
Other Names:
Radiation: Whole-brain radiation therapy (WBRT)
Undergo WBRT
Other Names:
Radiation: Stereotactic radiosurgery (SRS)
Undergo SRS
Procedure: Cognitive assessment
Ancillary studies
Other: Laboratory biomarker analysis
Correlative studies
- Maximum-tolerated Dose (MTD) of RO4929097 in Combination With Whole-brain Radiotherapy (WBRT) [ Time Frame: 4 weeks ]Maximum-tolerated dose (MTD) of RO4929097 in combination with WBRT, determined according to incidence of dose limiting toxicity (DLT) graded using the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 (Phase I)
- MTD of RO4929097 in Combination With Stereotactic Surgery (SRS) [ Time Frame: 4 weeks ]MTD of RO4929097 in combination with SRS, determined according to incidence of DLT graded using the NCI CTCAE version 4.0 (phase I)
- Response Rate (Complete or Partial Response) (Phase II) [ Time Frame: 12 weeks ]Only participants with measurable disease present at baseline, received at least 6 weeks of therapy, and had disease re-evaluated considered evaluable for response. Complete Response (CR): Disappearance all lesions; Partial Response (PR): =/>50% decrease in sum bidimensional products all lesions reference baseline sum of bidimensional products of all lesions; Progressive Disease (PD): >25% increase in sum bidimensional products of lesions, or progression of any treated lesion not target lesion, or appearance of 1 or > new lesions at least 6 mm in unidimensional size. Stable Disease (SD): Neither sufficient shrinkage for PR nor increase for PD, reference smallest sum of bidimensional products of all lesions.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients who have histologically or cytologically confirmed breast cancer or other cancers (such as lung cancer, melanoma, etc) with newly diagnosed metastatic disease to the brain will be eligible for the Phase 1 study only, however, those patients who have available systemic therapeutic options with a demonstrated survival benefit will not be eligible; for Phase 2, patients must have histologically or cytologically confirmed estrogen receptor negative breast cancer with newly diagnosed metastatic disease to the brain
- Patients must have measurable disease in the brain, defined as at least one lesion that can be accurately measured in at least two dimensions (longest diameter and its longest perpendicular diameter to be recorded)
- There is no limit on type or number of prior therapies, except that prior therapy with notch inhibitors is not allowed, and patients should not have received prior cranial radiation; therapy naïve patients are eligible; at least 14 days (2 weeks) must have elapsed from any prior experimental therapy, chemotherapy or radiotherapy; toxicities from prior chemotherapy or radiotherapy should have resolved to < grade 2; patients with newly diagnosed brain metastases who have received therapeutic regimens with well-characterized, delayed toxicity (e.g. hematologic toxicity observed following carmustine [BCNU] or mitomycin C) will not receive experimental therapy until the patient has adequately recovered from all drug related toxicities
- Karnofsky performance status (KPS) >= 70%; Recursive Partitioning Analysis (RPA) class I or II; a small feasibility cohort of 10 RPA class III (KPS < 70%) patients may be enrolled, however these patients, if enrolled will not be included in the efficacy analysis
- Hemoglobin >= 9g/dL
- Absolute neutrophil count >= 1,000/mcL
- Platelets >= 100,000/mcL
- Total bilirubin within normal institutional limits
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) =< 2.5 x institutional upper limit of normal
- Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional upper limits of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- Tumor HER2/neu status may be positive or negative
- Women of childbearing potential and men must use two forms of contraception (i.e., barrier contraception and one other method of contraception) for the duration of study participation, and for at least 12 months post-treatment; should a woman become pregnant or suspect she is pregnant while she or her partner are participating in this study and for 12 months after study participation, the patient should inform the treating physician immediately; prior to dispensing RO4929097, the investigator must confirm and document the patient's agreement to the use of two contraceptive methods, dates of negative pregnancy test, and confirm the patient's understanding of the teratogenic potential of RO4929097
- Ability to understand and the willingness to sign a written informed consent document
- A tumor site (outside the central nervous system) for needle biopsy for research purposes is preferable
- Ability to swallow pills
Exclusion Criteria:
- At least 14 days (2 weeks) must have elapsed from any prior experimental therapy, chemotherapy or radiotherapy; toxicities from prior chemotherapy or radiotherapy should have resolved to < grade 2
- Patients may not be receiving any other investigational agents
- Patients with leptomeningeal metastases should be excluded from this clinical trial
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to RO4929097
- Patients taking medications with narrow therapeutic indices that are metabolized by cytochrome P450 (CYP450), including warfarin sodium (Coumadin®) are ineligible
- Patients taking medications that are generally accepted by the QTdrugs.org Advisory Board to carry a risk of torsades de pointes, including antiemetics, are ineligible
- Preclinical studies indicate that RO4929097 is a substrate of CYP450 family 3, subfamily A, polypeptide 4 (CYP3A4) and inducer of CYP3A4 enzyme activity; caution should be exercised when dosing RO4929097 concurrently with CYP3A4 substrates, inducers, and/or inhibitors; furthermore, patients who are taking concurrent medications that are strong inducers/inhibitors or substrates of CYP3A4 should be switched to alternative medications to minimize any potential risk; if such patients cannot be switched to alternative medications, they will be ineligible to participate in this study
- Patients with malabsorption syndrome or other condition that would interfere with intestinal absorption; patients must be able to swallow tablets
- Patients who are known to be serologically positive for hepatitis A, B or C, or have a history of liver disease, other forms of hepatitis or cirrhosis are ineligible
- Patients with uncontrolled hypocalcemia, hypomagnesemia, hyponatremia, hypophosphatemia or hypokalemia defined as less than the lower limit of normal for the institution, despite adequate electrolyte supplementation are excluded from this study
- Uncontrolled electrolyte abnormalities including hypocalcemia, hypomagnesemia, and hypokalemia; uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association [NYHA] class III or IV), unstable angina pectoris, a history of torsades de pointes or other significant cardiac arrhythmias, stable atrial fibrillation, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with RO4929097
- Cardiovascular: baseline QTcF > 450 msec (male) or QTcF > 470 msec (female)
- Patients who have not recovered to < Common Terminology Criteria for Adverse Events (CTCAE) grade 2 toxicities related to prior therapy are not eligible to participate in this study
- A requirement for antiarrhythmics or other medications known to prolong QTc
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01217411
|United States, Massachusetts
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02115
|United States, Texas
|M D Anderson Cancer Center
|Houston, Texas, United States, 77030
|Principal Investigator:
|Morris Groves
|M.D. Anderson Cancer Center
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01217411 History of Changes
|Other Study ID Numbers:
NCI-2011-02533 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
2009-0582 ( Other Identifier: M D Anderson Cancer Center )
8543 ( Other Identifier: CTEP )
U01CA069852 ( U.S. NIH Grant/Contract )
U01CA062461 ( U.S. NIH Grant/Contract )
N01CM00039 ( U.S. NIH Grant/Contract )
U01CA076576 ( U.S. NIH Grant/Contract )
P30CA016672 ( U.S. NIH Grant/Contract )
|First Posted:
|October 8, 2010 Key Record Dates
|Results First Posted:
|February 6, 2015
|Last Update Posted:
|February 6, 2015
|Last Verified:
|October 2011
Additional relevant MeSH terms:
Breast Neoplasms
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Small Cell Lung Carcinoma
Breast Neoplasms, Male
Neoplasms by Site
Breast Diseases
Skin Diseases
Respiratory Tract Neoplasms
Thoracic Neoplasms
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Nevi and Melanomas


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Price range, per nightmin R max R
Ballito, Underberg, Durban, Bluff, Margate, St Lucia, Hluhluwe, Newcastle, Durban Beachfront, Amanzimtoti, Umdloti Beach, Umhlanga, Zinkwazi Beach, Port Edward, Umhlanga Rocks, Durban North, Pietermaritzburg, Shelly beach, Morningside, Richards Bay
The north-east province of KwaZulu Natal [KZN] in South Africa was once the scene of regular land disputes between Zulu tribes and British colonists. Today, all their descendants peacefully coexist in this desirable region of South Africa.
KZN encompasses much of the best South Africa has to offer; it has the highest mountain peaks, 2 UNESCO world heritage sites, unique marine reserves, idyllic swimming beaches, modern progressive cities, traditional lands, battlefields, diverse wildlife, adventure sports and strong cultural influences.
The province's climate contrasts between subtropical, warm temperatures along the coastline to cool, sub-alpine weather in the higher mountainous region in the west. So too is the contrast evident in living spaces where modern cities like Durban, actively participating in the world's economy, are a short drive away from tribal villages following ancient traditions.
South Africa's constitution, under the Traditional Leadership clause, allows for the country's only monarchy to exist in KZN and the Zulu nation is currently ruled over by King Zwelithini.
The entire region that makes up KwaZulu Natal is a place of beauty, hence Natal is known as the Garden Province of South Africa..
Things to do
The warm Indian Ocean along KZNs coastline is perfect for swimming, fishing and surfing. Many beaches deploy shark nets to ensure the safety of bathers and surfers. Durban is known as Surf City where there is no need for a wetsuit. Take a road trip along the vast coastline to enjoy the plethora of glorious beaches.
The Sardine Run along the KZN coastline occurs annually between June and July and is a spectacle comparable with any of nature's great mass migrations. Hordes of sardine shoals move up the coast while masses of predators feast on them, causing the sea to bubble with activity. Locals rush to the shoreline to scoop up the sardines while brave divers venture in amongst the shoals.
KZN hosts two world renowned sporting events; the 89km Comrades Marathon, the world's greatest ultra-marathon, and the popular Dusi Canoe Marathon, a 120km 3-day canoe endurance race along the Dusi River.
uShaka Marine World is an enormous theme park in Durban to keep the entire family enthralled. The park has 4 areas; uShaka Sea World, uShaka Wet 'n Wild, uShaka Beach, and uShaka Village Walk, all offering unique entertainment, dining and shopping experiences.
If you enjoy adventure sports, visit the Moses Mabhida Stadium in Durban to attempt the world's only stadium swing 100m above the turf. Another option is the Wild Gorge Swing at Oribi Gorge, the world's highest swing that plummets 165m down into the gorge.
If history and architecture interests you, then the KZN capital city of Pietermaritzburg should be your first stop. Known as the Last Outpost of the British Empire, it is one of the best preserved Victorian cities in the world. Tours of the historic battlefields surrounding the city are worthwhile.
Locals wanting to avoid crowded beaches head inland to the scenic Midmar Dam to enjoy activities such as boating, cycling, hiking, horse riding and rock climbing. Overnight stays are possible and the small game park has an abundance of non-threatening wildlife.
The dramatic Drakensberg Mountains, a world heritage site in the Royal Natal National Park, offers scenic splendour where ancient volcanic rocks, exposed by erosion over millennia, can be explored on foot or horseback. A popular hike up the gorge traverses The Tunnel where boulder-hopping brings you out to the magnificent Amphitheatre, an overwhelming majestic stone cliff rising over 3000m into the heavens.
Take a sojourn into the undeveloped wild areas of the Elephant Coast, incorporating Kosi Bay's lake district, the iSimangaliso Wetlands Park (world heritage site), Sodwana Bay reefs and the Hluhluwe iMfolozi Game Park. Expect to see the Big 7 – lion, leopard, elephant, rhino and buffalo on land and whales and great white sharks in the sea. Schools of dolphins abound.
Tp gain understanding of Zulu culture visit the authentic Dumazulu Cultural Village outside Hluhluwe. Activities include weapon and craft making, the opportunity to see a Zulu war dance and a reading from the resident Sangoma (witch doctor).
For an unusual cultural experience, visit some temples, mosques and churches surrounding the city of Durban and Pietermaritzburg. Worth a mention are the Sri Siva Soobramoniar Hindu Temple, the Mariannhill Monastery and the Hare Krishna Temple of Understanding.
Durban is a tourist hotspot, best known for its Golden Mile, a stretch of beautiful beaches overlooked by large hotels and resorts. It's a vibrant, fluid city run by innovative administrators and broadminded entrepreneurs. The harbour is the largest and busiest in South Africa.
Where to Eat
There are excellent restaurants spread throughout this region. The diverse KZN population of Nguni, Zulu, Xhosa, Ndebele and Swazi, Indian, British, Dutch and German descendants brings with it a melting pot of food flavours and techniques which, when combined, creates unique dishes. Here are 5 of the best:
The cuisine at The Gorge Fine Dining Restaurant at Oribi Gorge can best be described as divine. The venue is set alongside the stunning gorge and the interior is bright and welcoming.
Exquisite dishes on offer at The Grill Room at the Oyster Box Hotel Restaurant in Umhlanga are complemented by an old world interior and excellent wine choices available on the menu.
iSibaya Restaurant located at the Woodridge Country Hotel and Spa in the Natal Midlands offers top quality dishes around a boma and under thatch. Dishes are given the African treatment.
Gigi's in Ballito is a contemporary, vibrant restaurant serving delightful dishes inside or out on the terrace. The kitchen is open for diners to watch their meals being prepared from scratch. The venue has a private 12-seater area for business power meetings.
Café 1999 in the heart of Durban offers cosmopolitan dishes all flawlessly presented. The prawn and chorizo aglio olio dish is a favourite.
Night Life
All coastal towns have some form of night entertainment, be it a sports bar or club where locals and visitors can hang out. They are too many to single out. The big cities like Durban, Pietermaritzburg and Margate have a sophisticated and varied nightlife.
Where to Stay
The accommodation options dotted up and down the coast of KZN, some inland, are sure to complement a holiday to the area. The options vary from small well-equipped sea facing apartments to exclusive lodges, giving visitors amazing good value . Being a popular destination, KZN accommodation owners provide first-rate service to their guests.
Air The only international airport in KZN is Durban's King Shaka International Airport, however, there are many other smaller airports and landing strips throughout the province for private charters or inter-linking domestic flights.
Car Order a vehicle online or visit a rental agency at all major cities and airports.
Taxi Most towns and cities have taxi or shuttle services available .
Bus There are many bus services, including national carriers, for easy access in and between towns.
Did you know?
The small town of Howick, north-west of Pietermaritzburg, is where Nelson Mandela spent his last day of freedom before being arrested in 1962. The town is also known for its waterfall, a mystical place believed by some to be the home of the monster Inkhanyamba, a giant horse-like creature sparking thunder & lightning when angered.
Another small town, Dundee, was the centre of many a battle and over many years that involved the Boer, the Brit and the Zulu. Famous personalities such as Mahatma Ghandi, Winston Churchill and Prince Louis Napoleon have direct links to this town.
Guests truly make their accommodation and integral part of their holiday when they opt to stay in a houseboat. There is a wide variety of options when it comes to Houseboating. For guests with seafaring experience, and a skippers licence, there is the opportunity to commandeer your own boathouse, and enjoy the flexibility and freedom it offers. These smaller boathouses can sleep up-to five people and offer basic amenities for self-catering. For guests wanting or willing to let someone else do the boating there are both economy and luxury houseboating options to choose from. Economy is ideal for larger groups, and guest who want a more hands-on approach to their holiday. Guests preferring smaller groups, or wanting to simply take in the experience, luxury is the way to go. Extra's on a luxury houseboat include full ensuite cabins, all meals made by the boats chef, and full deluxe amenities.
Updating Results...


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The Hong Kong Stock Exchange named industry veteran Garry Jones as the CEO of the London Metal Exchange, selecting a former top executive at the NYSE Liffe to help drive its expansion into commodities and beyond.
Tethys Petroleum announced the appointment of Stephen Elliott to the position of vice president project development. Elliot has been with the company since April 2009. In his new corporate role, Steve will now have overall responsibility for Tethys' operated projects at the project stage in all countries of focus.
R.J. O'Brien & Associates announced that Matthew Ardizzone, a 20-year veteran of the foreign exchange (FX) industry, has joined the firm as Global Head of FX Sales. Ardizzone is charged with growing the firm's institutional FX presence, particularly among commodity trading advisors (CTAs), hedge funds and FX portfolio managers.
OCC announced that Chairman and Chief Executive Officer Wayne P. Luthringshausen will retire effective December 31, 2013. Pending regulatory approval, OCC will separate the roles of Chairman and CEO upon Luthringshausen's retirement. After an extensive national search OCC's Board of Directors has named Michael E. Cahill as CEO effective January 1, 2014.
Embium announced that Janice Robson has joined Embium as CEO. Her appointment brings critical strategy and sales expertise to facilitate Embium's rapid growth.
Lightyear Capital LLC recently appointed Richard Korhammer, co-founder and former Chairman and CEO of Lava Trading Inc., as Senior Advisor. Korhammer will draw upon his extensive background in financial technology to help identify and evaluate financial technology and capital markets investment opportunities for Lightyear
Orc announced that Troels Philip Jensen has been appointed Chief Operating Officer to support Orc's global strategic objectives and growth. He succeeds Matteo Carcano who is leaving the company in August 2013.
Horizon Cash Management LLC announced that it has hired Matthew Boice as vice president and credit analyst. Boice works closely with the portfolio management team and chief investment officer and is responsible for portfolio credit research.


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Selecting your vehicle's make, model, and year allows us to display only parts and items specific to your car's model and year.
Part# C240541
1 Review
OPGI Price: $29.99
Part Type: (R) = Authentic reproduction of the original GM product
Years: 1969-1971
Sold As: EACH
Reproduction covers are ideal for all deluxe seat belt buckles. Each stamped steel cover features an authentic brushed finish for a factory-correct appearance. Covers for 1966-68 are available in one size only, while covers for 1969-73 are available in either small (1-3/4" x 1-1/2") or large (2-9/16" x 2-1/8"). Sold per each.


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Warm, sunny weekend ahead
And on the 13th day -- Friday -- there will be sun and warmth.
Chalk that up also for the 14 and 15th post-Sandy, post-nor'easter days also, according to meteorologists.
"It's a good weekend forecast," said David Stark, a meteorologist with the National Weather Service in Upton, N.Y.
"We should have clear skies Friday with temperatures in the high 50s ... We got a warm front coming through Saturday that might give us some cloud cover but no precipitation. And Sunday should be sunny with temperatures in the low 60s."
But wait, there's a cold front coming through sometime Monday night or early Tuesday that will bring some showers.
"But it's nothing significant," Stark said.
That's good news for the local power companies.
Late Thursday afternoon, Connecticut Light and Power was dealing with an equipment problem at the New Canaan Avenue substation. Around 3 p.m. Thursday, 4,000 Norwalkers were without power. All were restored later in the evening.
United Illuminating crews were dealing with a downed wire in Fairfield that knocked out power for 453 customers around 5 p.m.
Michael West, UI's director of corporation communications, said as many as 14,000 customers in their service area were without power during the peak of the nor'easter Wednesday.
"We quickly restored 13,500 by morning," he said.
Both West and Mitch Gross, a CL&P spokesman, said the crews sent from out-of-state power companies to help with storm damage from Sandy and the nor'easter were on their way to New York and New Jersey to help with outages in those states.
"We're sending 60 CL&P crews to ConEd in New York to help out there," Gross said.
If wonderful weekend weather was not good enough news for the weary, Gov. Dannel P. Malloy announced the newly renovated service plaza on the northbound side of the Merritt Parkway in Fairfield will reopen at noon Friday, providing gas and food.
"It is important that we make as many fueling locations available as we can, especially in Southwestern Connecticut, which sustained back-to-back hits from these two storms," Malloy said. He said the service plaza also has full generator capabilities.
The southbound service plaza remains under reconstruction and will open within the next couple of months, the governor said. This week's plan to close the Merritt Parkway service plazas in Greenwich on both the northbound and southbound sides for renovations is being delayed until after Thanksgiving to minimize the impact on travelers looking for fuel and food, Malloy said.
An influx of motorists from New York and New Jersey have been driving to Connecticut to fill up.
New York City, Long Island and New Jersey have imposed odd-even day gasoline rationing to deal with fuel shortages and long lines at gas stations. Motorists whose license plate ends in an odd digit or a letter are allowed to buy gasoline only on odd-numbered calendar days.
As a result they are coming to Connecticut.
State Police Sgt. Mark Grasso, of the fire and explosion investigation unit, said last weekend he received calls from three different agencies dealing with this issue, some filling unapproved containers.
"Orange intercepted an individual who purchased 35 Home Depot `Homer' five-gallon pails, filled them with gasoline at a Valero gas station and loaded them into a Nissan Quest minivan," Grasso said. "Stratford intercepted a similar situation with individuals filling unapproved, plastic, 55 gallon containers, and Bethel intercepted an individual filling spring water bottles."
On Monday, Mohd Awawdeh, 35, the owner of the Shell gas station at 1139 Post Road in Fairfield, was charged with violating the state regulation regarding the transport of flammable liquids after two men were observed filling up 55-gallon drums of gas in the back of a pickup truck at his station. Police said the two men told them they worked for a New York trucking company and needed the gas so their trucks could run.
They were not charged, and the gas was poured back into the station's tank.
Justin Tyrell said he had stopped at the gas station to buy cigarettes when he saw the men pumping gas into the barrels and called police.
"It was definitely strange what they were doing, and I felt it wasn't safe," he said. "I was afraid they were going to put everyone else on the road in danger if they were allowed to leave. One small incident and it would have all been over."
Wednesday's nor'easter dropped anywhere from 11.5 inches of snow in Monroe to 5.5 inches in Ansonia. Seymour and Orange received 9 inches; Bridgeport 8 inches, Trumbull and Oxford 6 inches, according to the National Weather Service.
The snow was laden with water, making it heavy to shovel but easy to build snowmen.
That's exactly what the Pagliaro children in Trumbull did on their day off from school.
Their snowmen resembled an electric company lineman complete with hardhat, fluorescent gloves and blue jacket. Michael, 14, Kristen, 12 and Caroline, 8 added a sign that read: "Thanks UI and CL&P for all your hard work during these storms!!!" Their father, Jim, works for CL&P.
The heavy snow and slick roads caused superintendents in such places as Ansonia, Derby, Milford, Monroe and Seymour to cancel school Thursday, while Bridgeport, Danbury and Stamford officials imposed 90-minute delays.
State police said two drivers were killed in separate accidents in East Granby and Lebanon.


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Police in Alabama say a missing teenager and her abductors may be hiding in Western Louisiana or East Texas.
According to a press release from the Dothan Police Department, Ailene Lander, 15, was abducted from a medical facility on Sept. 17. Police believe her abductor is Charles "Dean" Partin, 36, a truck driver, who was later joined by Julie Bethke.
Police believe Lander and the abductors are most likely located in East Texas or West Louisiana.
At the time of the abduction, Lander was wearing a white short and white and pink shorts. Her hair may now be blonde and police believe she is in physical and medical danger.
Partin was wearing a baseball cap, a dark-colored shirt and dark jeans. He is believed to have fled in a two-tone light blue over dark blue 1994 Mercury Villager but may have changed to a blue or green Toyota minivan.
Partin is most likely seeking assistance at various charitable organizations.
Anyone with information on this case should call 1-800-CALLFBI (225-5324) and choose option one.


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Online Students
Earn your degree online.
Why do motivated students choose Central Penn College?
They get a real world career education. They learn from professors who are experienced experts in their disciplines. And they earn a degree that helps them advance their careers and improve their lives.
Everything that makes Central Penn the right choice for onsite students applies to online learning.
Sure, the schedule is flexible and convenient. You can log on and learn on your schedule. But the courses are every bit as challenging and real. Online learning is more than an Internet connection. You get a personal connection to your professors, your college and your peers. And if you choose you can take advantage of all the educational, career and community resources Central Penn offers onsite, in person.
It takes self discipline, self management and unusual drive to be an online student at Central Penn. But if you have a busy life and are up to the challenge of pursuing more education, you probably already have those qualities. And if you want a more challenging career, there's no better way to make it happen than with online courses at Central Penn.


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Jailbreaking iPhone 4S 5.0/5.0.1 With Absinthe On Windows
There are two methods of jailbreaking iPhone 4S on 5.0 or 5.0.1 firmware for windows. The first one is the command line method released by the iPhone Dev-Team and the second one is the Absinthe jailbreak tool that was released by Chronic Dev-Team. We will discuss the second, Absinthe method as command line method is not suggestible for users new to jailbreaking.
Please take a back up of your iPhone data as you might lose your photos. So just to be on the safe side, you can restore from the back up in case you lose your photos. You can follow this post to back up your iPhone data. Otherwise proceed with the instructions below to jailbreak your iPhone 4S.
Step 1: Download the latest version of Absinthe
Step 2: Connect your iPhone 4S to the computer and launch Absinthe. Please make sure to remove any password lock if you have along with the vpn settings if you had configured them at all.
Step 3: Click on the jailbreak button in Absinthe and the jailbreak process will begin. Do you interrupt the jailbreak progress and wait for it to complete.
Step 4: After a while Absinthe will inform you that jailbreak is almost done.
Step 5: From the springboard, launch Absinthe to complete the jailbreak process. Once done, your device will reboot and you should now see Cydia on your springboard which means your iPhone 4S jailbreak was successful.
Guide to help you back up your iPhone data
Guide to update iPhone without upgrading the baseband
Recent Articles
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GraffixPro Studio® T-Shirt Design Software is an easy-to-use software application that lets you quickly create beautiful designs for your Direct-to-Garment Printer
GraffixPro Studio® software now available!Check out our videos for a visual tour of GraffixPro Studio® software and how it can be an asset to your business.
Intuitive and powerful, this software comes with over 40 fonts and over 300+ images and elements and a library of garment templates, so you can quickly create a personalized design, view it on a garment template and send it to the printer in 3 easy steps.
No need to learn complicated graphics software or photo editing programs - GraffixPro Studio® software includes artwork manipulation, distressed effects, shadows, gradients, and more, so you can take basic artwork and quickly turn it into an artistic design. Complex, artistic designs cannot easily be screen printed. With GraffixPro Studio® Software combined with the digital direct to garment printing process, you can get an edge over screen printing, with designs showcasing intricate gradation, drop shadows and other effects. See how easy it is to achieve higher quality, intricate designs, without putting in hours of effort.
Key Features Of GraffixPro Studio® Software
1. Intuitive Software, Easy-To-Use Features:
If you love being creative but don't have the time to learn a complicated software program-then this software is for you! Simply select a garment, pick a design, add text, make adjustments if you'd like to, and you're ready to print! The design effects you can create with GraffixPro Studio® software are truly amazing and easy to accomplish. Easily rotate, resize text or images, add distressed mask or an outline, or change colors... create complex, artistic, personalized images in a matter of minutes! Learn more...
5. Artwork Manipulation:
There is real magic in how quickly and easily GraffixPro Studio® software lets you transform a regular image to a complex, fancy design.
2. Artwork/Image Library:
This software includes over 300 images/elements from two Action Illustrated Catalogs.† The designs are high resolution images in png format and are displayed in a book format that you can easily browse through and select. Or, if you prefer, find your design instantly with the Search Tool—without browsing through hundreds of designs. More designs will be made available for users to purchase online*†. Learn more...
6. Color Adjustment Features:
Change the colors in any artwork, add transparency, etc. like in any advanced graphics program, but without the complexity!
3. Font Collection:
With over 40 beautiful fonts already categorized, you can create impressive text instantly. And, it is super easy to add effects like arc text, outlines, gradients, distress or change colors. Quickly select a color from the design to use as the font color. Learn more...
7. Customize Your Software:
You also have the ability to customize the software: how it appears, what is shown in terms of garments, designs, fonts. This can be done through the GraffixPro Studio® Software Administrator. Learn more...
You can:
4. Garment Template Library:
GraffixPro Studio® software comes with some pre-loaded garment templates, and the user will be able to import in their own garment templates or other substrates as well. The user picks a garment template, and then can choose which part of the garment template to print on. The placement of the design on the garment template is helped by the platen border that shows the area that can be imprinted. Learn more...
8. Barcode Scanning:
A key new feature in version 2.0 (available only in the Premium level) is the ability to scan designs using a barcode.
Another new feature of version 2.0 is the ability to import EPS catalogs into the design gallery for use in GraffixPro Studio®. The file can be imported along with keywords that help retrieve/search designs later.
That's not all! There are other features like Quote Generator, WaterMark, Save as Template, etc that make the software even more powerful.


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Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on Amazon at the time of purchase will apply to the purchase of this product.
Orders fullfilled by Amazon.com
US Pride Furniture introduces a sofa, loveseat and chair bonded leather set with a splayed chrome leg finish. Designed with incredible dimensions of 35" x 74.5" x 30" loveseat measurements of 35" x 56.5" x 30" and chair measurements of 35" x 40.5" x 30" a total weight of only 236 lbs., this set will easily fit in your home without taking up too much space. Crafted from quality bonded leather, plush foam filling and a chrome leg finish, it is clear that this is a set that will be durable and long lasting in your home for years to come. Enjoy the tufted design finish and the low armrests. This is a great addition to your living room decor. US Pride Furniture has been dedicated to creating quality furniture at an affordable rate for several years. As a growing company, US Pride Furniture continues to offer customers the latest array of quality-consistent, fashionable furniture styles and designs just for you.


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Dear visitor, welcome to SPRINKLER TALK FORUM - You Got Questions, We've Got Answers. If this is your first visit here, please read the Help. It explains how this page works. You must be registered before you can use all the page's features. Please use the registration form, to register here or read more information about the registration process. If you are already registered, please login here.
Monday, September 26th 2005, 2:54pm
Supreme Member
Location: Metro NYC
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Selecting your vehicle's make, model, and year allows us to display only parts and items specific to your car's model and year.
Part# CH20314
Be the First to Review
OPGI Price: $129.99
Part Type: (P) High Performance, designed to improve performance
Years: 1978-1987
Sold As: KIT
These are some of the highest flowing air filters available today. They have a proprietary, reusable cotton gauze element that traps harmful airborne particles, yet allows more air to flow through than almost all other elements. The air filter kit comes with a drop base, element and a chrome lid with an embossed K&N logo.
INCLUDES: Drop base, 14" diameter element and chrome lid with K&N embossed logo.


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A friend sent me a link to a riding-buddy's pictures from the Giro – instant gratification. When I first started following cycling, you had to wait for Cycle Sport magazine to show up to see the first shots of the race. CyclingNews (then Bill's CyclingNews with the teal background) usually had the results posted within a couple of days.
Now we get live, streaming video, photos as they happen, and detailed same-day coverage. Add to the standard media sources all the user-driven sites like Flickr, Blogspot, and Twitter and you are surrounded by our sport. Gotta love those interwebs.
Big thanks to the folks at Glacier Bikes for keeping me in their loop.


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A blog about working with clay and selling pots
Monday, 29 November 2010
Christmas Sale preparations
Tea-light holders lined up...
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About Me
Holte, Sjælland, Denmark
Priscilla Mouritzen, South African-born ceramist, resident in Denmark since 1979
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The Summer Pots: Summer Rain, 2017, currently showing at Gallery 286, 286 Earl's Court Road, London SW5 9AS June 8th - 30th 2017
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Delgado can't set tone as D-backs fall in Cincinnati
CINCINNATI -- Randall Delgado didn't turn in the type of start the D-backs were hoping for, and their four-game series with the Reds didn't begin the way they wanted.
Other than that, it was a fine summer evening in the Queen City.View Full Game Coverage
CINCINNATI -- Randall Delgado didn't turn in the type of start the D-backs were hoping for, and their four-game series with the Reds didn't begin the way they wanted.
Other than that, it was a fine summer evening in the Queen City.View Full Game Coverage
Delgado allowed five runs over six innings as the Reds beat the D-backs, 5-3, on Monday night at Great American Ball Park.
With the loss, the D-backs fell six games behind the Reds in the battle for the final National League Wild Card spot. They did not lose any ground to the first-place Dodgers in the NL West, as they remain 7 1/2 games back.
"We've got to leave it behind and come tomorrow and even it up and try to win as many games as we can in this series," D-backs third baseman Martin Prado said.
With their bullpen taxed following a 16-inning game against the Pirates one day before, the D-backs were hoping Delgado (4-4) would pitch deep into the game.
That didn't happen.
"I feel like they had pretty good at-bats and they just scored when they needed to," Prado said. "We tried to come back, and actually it was a pretty close game. I feel like we had a couple opportunities where we could have put some more runs up, but unfortunately we couldn't."
The Reds scored a run in the second when Zack Cozart's sacrifice fly scored Brandon Phillips, who had led off the inning with a triple.
Phillips got the triple when center fielder Adam Eaton attempted to make the catch, and as the ball bounced off the wall, it got by him.
"He just got too close to the wall," D-backs manager Kirk Gibson said. "Early on, with nobody out, it's probably a ball you lay off and try to play it off the wall and get a guy on second with nobody out. That's just part of learning things. He thought he could catch it. He got too close, the ball got by him and they got a triple instead of a double and got an easy run out of it."
The D-backs tied the game in the fourth when Aaron Hill hit a two-out solo homer to left.
In the fourth, the Reds really taxed Delgado, forcing him to throw 25 pitches as they sent eight men to the plate, collecting three runs on four hits. Jay Bruce, Ryan Ludwick and Cozart each drove in runs during the inning, as the Reds went up, 4-1.
"If you can get consecutive hits, that's kind of what's missing around baseball," Reds manager Dusty Baker said. "When you get consecutive hits, you keep the pitcher in the stretch and you really can't get anybody loose on the other side quickly enough to stop it. That's great when you're getting those consecutive hits."
Looking back at the inning -- and his whole outing for that matter -- Delgado said he might have simply been throwing too many strikes and catching too much of the plate on a consistent basis.
"I felt good with the strike zone and everything," Delgado said. "But I should mix a little bit more. I was so over the plate, that every time they swung, they thought something was going to happen. I think I need to mix a little more and that's it."
Cincinnati added a run in the fifth when Todd Frazier led off with a home run.
The D-backs, who are second in the NL in comeback wins, made things interesting when they scored a pair of runs in the sixth on Prado's two-out bases-loaded single to close the gap to 5-3.
Bronson Arroyo (12-9) picked up the win for the Reds, as he allowed three runs on seven hits over six innings.
"It's a huge win for us," Arroyo said. "To get off to this series good, especially with me not feeling like I had my best stuff, it was nice."
Steve Gilbert is a reporter for MLB.com. Read his blog, Inside the D-backs, and follow him on Twitter @SteveGilbertMLB.


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encoreguy necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 184 diseños de 40 diseñadores freelance.
EncoreConnect is a start-up non-profit agency based in San Francisco that places dedicated, experienced adults in meaningful part-time jobs in social purpose work in education, healthcare, social service and environmental arenas throughout California.
There is increasing evidence that millions of Americans from the baby boomer generation are seeking ways to find more meaning in their lives and make a difference in their communities. If retired, they don't just want to play golf and bridge all day; if still working or looking for work, there is great interest in switching from private sector jobs to "encore careers" in social purpose work. (See http://www.encore.org for more context on the encore careers movement.) There is huge media interest in the "encore" movement and EncoreConnect is on the leading edge of this phenomenon.
The winning design will appear broadly online and in print, first throughout California and later across the country. We will provide attribution for the designer on our website and could likely have future work as the business expands.
Adults 50+ seeking to improve their communities and be involved through part-time social purpose work (many will be transitioning from private sector jobs), and hiring managers in non-profit agencies. Probably skews 65/45, female/male, highly educated.
We are looking for a clean, elegant logo, and are interested in considering either an all type logo and/or one with a graphic element. It should be no more than two color and also have black & white and knockout (all white) versions that work. We also want to see how the tagline - Experience. Passion. Purpose. - would be incorporated in terms of type and color. Because we are targeting multiple industries, including education, healthcare, social services and environment – green could be problematic as it may be seen as environmental.
In surveys and focus groups, some thought EncoreConnect conjured up a dating service or online ticketing service for theatre or music events, so it's important to avoid designs that indicate technology or music/performance, or dating. Our assumption is that the tagline (Experience. Passion. Purpose.) will help avoid some confusion.
Required File Formats
Please submit in .eps and .pdf
Lastly, as part of the final commissioned agreement the copyright will be sold to us as part of the contractual arrangement.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Arsenal midfielder Santi Cazorla doesn't believe managerial changes will have any effect on the title race next season and he's adamant that the race will be tighter than ever before.
Last year's campaign was won comfortably by Manchester United, as rivals Manchester City and Chelsea fell well off the pace behind the Old Trafford side.
However, ahead of the new season, a lot of people are wondering if United can continue their success under David Moyes, after he was appointed as the new manager, after Sir Alex Ferguson announced his retirement.
Moyes is now at Old Trafford and will not be going up against Roberto Mancini or Rafael Benitez for City and Chelsea, but instead will battle Manuel Pelligrini and Jose Mourinho.
Despite the three new managers at the top-three Premier League sides, the Arsenal midfielder doesn't believe that will change anything for next season.
Cazorla, who was impressive in his debut season in England, believes next year's race will be tighter than ever before.
"The most radical change is at Manchester United because Ferguson has been there for so long," the Spaniard told the official Arsenal Magazine.
"It will be a little difficult at the start for a new manager but I don't think it influences too much in terms of being an advantage for other teams. There are great managers at those clubs and I'm sure [the title race] will be just as difficult."
Cazorla was also asked about Pellegrini, as he worked with him during his time at Malaga and Villarreal and the Spaniard believes he will take City to the next level.
"I find it strange that some people don't know about him," he said. "He's done spectacular things with Malaga and Villarreal in the Champions League. Clubs like City obviously want him for a reason and, ultimately, it's for the job he's done.
"He's demonstrated he is top class. At whatever team he's been at - Malaga, Villarreal, Real Madrid - he's done well. He's had those teams playing spectacular football and I'm sure City will be a better team. I'm sure City's football will change and will be more offensive.
"I'm very happy for him because he deserves to be at a club of that level. He's getting his reward. He's been so important to my career."
Write for GiveMeSport! Sign-up to the GMS Writing Academy here: https://bit.ly/12evFlH
DISCLAIMER: This article has been written by a member of the GiveMeSport Writing Academy and does not represent the views of GiveMeSport.com or SportsNewMedia. The views and opinions expressed are solely that of the author credited at the top of this article. GiveMeSport.com and SportsNewMedia do not take any responsibility for the content of its contributors.


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October 11, 2008
ST. LOUIS, Mo. – The Little Giants used a balanced attack, featuring three Kody LeMond touchdown catches, to overpower Washington University, 37-12, here Saturday.
Wabash passed the 200-yard rushing mark for the third consecutive week and LeMond added to his spectacular sophomore season raising his touchdown total to 12 with three more against the Bears. (View photos from the game here and here.)
For the first time this season, Wabash couldn't score in the first quarter but put up 17 points in the second period. LeMond got things started when he broke free from a defender for a 30-yard score. Bobby Kimp then scored on a 17-yard run just five minutes later, 14-0.
Buck Smith scored from a yard out to get the Bears on the board. The score followed a beautiful short pass and 73-yard run by Greg Lachaud, who was aided by textbook downfield blocking. Washington scored again on a Kyle Gray 19-yard catch from Smith, 14-12.
Wabash closed out the half with Drew Oehler hitting a 34-yard field goal just before half.
Wabash (5-0) now prepares for its chief NCAC rival Wittenberg, in Springfield Saturday. Coach Erik Raeburn thought Washington, which defeated Wittenberg earlier this year, made for a good tuneup with its physical style of play.
"I felt like Washington University is a good football team," Raeburn said. "They're extremely well coached. Playing on the road, it was huge for us to play well and come and get a victory. Hopefully that will give us some confidence because we have to go on the road again this week .
"For the second week in a row our defensive line and linebackers really dominated up front and stopped the run themselves. We didn't have to bring any help from a safety that would make us vulnerable in the passing game. I'm really happy with how we played up front, being really physical again. And I thought we ran the ball really well again with Derrick Yoder , who I thought had his best game so far. Because of our running game we were able to hit Kody with some big pass plays."
The Bears could only must 7 rushing yards in the first half and only 4 first downs to Wabash's 13. Bobby Kimp paced the rushing effort with 93 yards for the game. Yoder added a career-best 82 yards on 14 carries. Evan Sobecki played in his second straight game, rushing for 28 yards in seven attempts.
"We have a three-headed animal now that Sobecki's back and getting healthy," Yoder said, referring to the Little Giants' running game. "We have a full stable back there. We all can run the ball. If one of us is down, we know there are two other guys who can come in and get things done.
"A lot of our success is due to confidence. We're seeing the holes faster and we're getting through the holes faster. We know our assignments. We're confident in the offense and we know how to execute now."
Wabash didn't let up in the third period and took over the game. The Little Giants scored midway through the period on a three-yard Matt Hudson pass to freshman Brady Young, 23-12. Hudson then found LeMond again wide open streaking down the sideline for a 47-yard score, 30-12.
The defense proved relentless allowing the Bears just nine yards rushing and 28 passing in the third period.
Wabash's final score was more than LeMond's speed. He caught the ball in traffic and then outmaneuvered three defenders to race more than 20 yards into the endzone. His three Saturday touchdowns and 165 yards puts him just five touchdowns behind Wabash record holder Ryan Short, who caught 17 TD passes in 2002.
"We've expected teams to roll their coverage to Kody, and they have the last two weeks, " Raeburn said. "Because we've run the ball well, they've had to bring that safety down and once we get one-on-one coverage we feel like Kody's going to win that matchup more times than not. "
The defense was dominating for the second straight week.
"One of our goals is to play physical," junior defensive lineman Matt Whyde said. "One indicator of that is rushing yards. The past few weeks we've really been able to shut teams down in the running game, and that gets them into being one dimensional. Then you have a much easier time defending them because you know they can't run the ball on you.
"We have freedom to play this season. We're allowed to be aggressive and to get after other teams. We started a little slow, but everyone is really getting comfortable with the new scheme. This is just the result."
Photos - (top right) Kody LeMond broke this tackle and scored the first of his three touchdowns.
(Bottom left) Wes Chamblee caught three passes for 34 yards and had two kickoff returns for 73 yards in the Little Giants' win in St. Louis.


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Two-car and bus accident leaves two injured
STANDISH — A three-vehicle accident the afternoon of Monday, Feb. 20 left two people hospitalized, as a van was crushed between another van and a school bus.
According to Arenac County Undersheriff Don McIntyre, the drivers of the two vans were taken to St. Mary's of Michigan Standish Hospital with non-life threatening injuries. He said there were high school students on the bus at the time of the incident, but there were no injuries.
McIntyre said the accident occurred as the three vehicles were heading northbound on US-23 in Standish, as the bus was slowing down to cross railroad tracks. The rear van rear-ended the middle van, pushing it into the school bus, he said, and the middle van caught fire after the collision.
"The bus is raised up, so the van slid underneath, which caused all the damage," McIntyre said. "Basically it looks worse than it really is."
The Standish Area Fire Authority was on hand in minutes to put out the vehicle fire, and McIntyre praised the firefighters' speedy response time.
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Arcade Sushi Quick Tips – Fixing the Xbox One Black Screen Error
Xbox One users are reporting an unfortunate error after a recent update. The error causes their Xbox One to go completely black after the startup screen. The console suddenly does not respond in any way to a controller. The only thing you can do is turn your Xbox One off and on again. Unfortunately, this doesn't really fix the problem. Users afflicted with the error find that they boot right up again, past the startup screen, right back into a gaping black void. So, how do you avoid this Xbox One black screen of perpetual nothingness?
The answer, as is the answer for most electronics problems, is "turning it off and on again." Yes, most users have tried that, but they haven't really turned their Xbox One off. They have merely put it to "sleep." The Xbox One is still retaining data in its RAM in this state, and that seems to be influencing the occurrence of the error.
So to "fix" the error, you actually have to cut all power to your Xbox One completely, which actually involves more than simply hitting the power button. To "power cycle" your Xbox One, simply hold down the power button for 10 seconds. The console should fully power off. At this point, the black screen error should go away, but to be extra careful, unplug your console and leave it unplugged for a few minutes. This should basically cut all power to the unit, and flush all of its memory. After that just plug it in, turn it on, and get back to your Titanfall Beta.
Note, that this doesn't actually fix the error completely. It's really just a workaround. It's possible that you will encounter the black screen again, but to clear it up all you have to do is power cycle your machine again. Microsoft has said that another major Xbox One patch will be coming In early March, and this will likely fix the issue.
Aside from patching in this error, the latest Xbox One patch also introduced a new battery life indicator and added USB keyboard support, so it's not all bad. The error also isn't dangerous; it's just annoying. Power cycling seems to get past the black screen basically 100% of the time, and your data, save games and accounts aren't affected by the black screen in any way. We will bring you more information on this strange error as it becomes available.


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Chiefs' Siler starts in place of deceased friend Belcher
Brandon Siler was hoping he'd get his chance with the Chiefs, but not like this. The tragic news of Jovan Belcher's murder-suicide hit Siler harder than most. Belcher, the team's starting middle linebacker, and Siler, his backup, were friends and sat next to each other during daily meetings. Siler spent this past Saturday mourning the death of his teammate after it became public that Belcher shot Kasandra Perkins, his girlfriend and the mother of their three-month old daughter, and then… Read More »