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Prometheus Announces New Chief Medical Officer
Nov 14, 2011, 11:19 ET
SAN DIEGO, Nov. 14, 2011 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, today announced the appointment of Dr. Peter Heseltine as Senior Vice President and Chief Medical Officer.
Dr. Heseltine joins Prometheus with almost 35 years of experience in the medical field. He comes most recently from Beckman Coulter where he served as Vice President and Medical Director of Global Businesses since 2005. In this role he had corporate responsibility for medical input and oversight of in vitro diagnostics product design, development and life cycle management, including new cancer diagnostics, using immunoassay, flow cytometry and molecular technologies.
Prior to joining Beckman Coulter, Dr. Heseltine was Medical Director of Infectious Diseases at Nichols Institute Quest Diagnostics supervising high-volume, Molecular, Microbiology, Virology and Serology clinical laboratories. He formed a team of research scientists to develop new esoteric tests for infectious diseases under ISO 9001 standards and led a Six Sigma quality improvement program that introduced more than 50 new tests in four years. Prior to joining Quest Diagnostics, Dr. Heseltine was a Chief Physician at Los Angeles County USC Hospital and Professor of Medicine at the University of Southern California. Dr. Heseltine received his medical training at Trinity College, Dublin University and postgraduate training at Yale University, the University of California, Los Angeles and the U. S. Centers for Disease Control. He is Board certified in Internal Medicine and Infectious Diseases. Dr. Heseltine is a Fellow of the American College of Physicians, Fellow of the National Academy of Clinical Biochemistry and a Fellow of the Infectious Diseases Society of America. He maintains a position as Clinical Professor of Medicine at the University of California, Irvine.
"Peter brings a wealth of medical, clinical and product development experience which will be very valuable during this important stage of our company's growth," said Joseph M. Limber, President and Chief Executive Officer of Prometheus. "He is a welcome addition to our senior management team and will play a key role in planning and executing our core strategy as we continue to build on our success."
About Prometheus
Prometheus Laboratories Inc. is committed to improving lives through the development and commercialization of novel pharmaceutical and diagnostic products that enable physicians to provide greater individualized patient care. Prometheus is a leader in applying the principles of personalized medicine to the diagnosis and treatment of gastrointestinal diseases and is applying these principles to oncology. Its strategy includes the marketing and delivery of pharmaceutical products complemented by proprietary diagnostic testing services. By integrating therapeutics and diagnostics, Prometheus believes it can provide physicians with more targeted solutions to optimize care for their patients. Prometheus became part of Nestle Health Science in July 2011. Prometheus' corporate offices are located in San Diego, California. For more information about Prometheus, please visit www.prometheuslabs.com.
About Nestle Health Science
Nestle Health Science, a fully-owned subsidiary of Nestle S.A., is operational since January 1, 2011 and has worldwide headquarters in Lutry, Switzerland. Nestle Health Science offers nutritional solutions for people with specific dietary needs related to illnesses, disease states or the special challenges of different life stages. For more information about Nestle Health Science, please visit www.nestlehealthscience.com.
SOURCE Prometheus Laboratories Inc.


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Most domain names for your Shopify store now cost just $9. If you're using the free yourstore.myshopify.com address for your online store, now is the time to register your store a professional domain name. The benefits of owning your own domain are plenty, and using Shopify to register a domain is fast and easy.
Does your online store already have a custom domain name? It's a good idea to protect your brand name and register all other possible domain extensions for your online store.
Here are the benefits of registering a .com, .net or other domain name with Shopify:
- It's the easiest, fastest way to register and activate a domain for your store.
- You receive 1 year of use, automatically renewed until you cancel your Shopify store or domain.
- We handle all the technical stuff like DNS settings and CNAMEs.
- Automatic setup of http://yourstore.com, http://www.yourstore.com and http://shop.yourstore.com.
- Optional access to full DNS configuration and WHOIS details, in case you need to make manual changes.
Already have a custom domain name?Even if you already have a domain name for your online store, you should protect your brand by registering other domain extensions. For example, if you own yourstore.com you should consider getting yourstore.net, yourstore.info, etc. as well. If you plan on selling in international markets, you may also want to consider getting country specific domain names like yourstore.ca, yourstore.co.uk, yourstore.com.au, etc. Shopify supports registering and allowing your store to be accessed by multiple domain names.
Owning multiple domain names is especially important for established businesses that plan on growing and expanding operations. If you delay and someone else picks them up, you may be unable to obtain them or be forced to spend a lot of money to register them at a later date.
Check our latest post for a list of business name generator tools to help you find the perfect domain name.
Join 446,005 entrepreneurs who already have a head start.
Get free online marketing tips and resources delivered directly to your inbox.
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You'll start receiving free tips and resources soon. In the meantime, start building your store with a free 14-day trial of Shopify.
10 comments
January 07 2013, 11:27AM
That's good news Mark! One quick query – on the two free email addresses that redirect, last I heard this was no longer in place. I removed it from the book. Is it back?
January 07 2013, 02:16PM
How can I get the domain I currently own to show up in the title? I have it forwarded to My Shopify, but i don't like how it breaks my brand, and then shows the shopify address. Please help
January 07 2013, 03:32PM
Hey James,
Give support.shopify.com a shout and they will be able to walk you through it. Blog comments aren't the best for troubleshooting these kind of issues.
January 07 2013, 07:36PM
I just love shopify. They are soooo kind and always get things I need done. KEEP UP THE GREAT WORK!!!!!
January 08 2013, 03:01PM
This is great and to answer my own question I was going to ask, you can tie email addresses to your domain with gmail – http://wiki.shopify.com/Google_Apps_Email_Setup
January 11 2013, 07:45AM
Where can i search to see if my ideal domain name is available?
January 17 2013, 12:37PM
I want to use hiphopfoods.net or .com how do i go threw this process
January 17 2013, 08:24PM
Can people checkout on https://newcustomdomain.com yet?
April 09 2013, 07:01AM
Today i came across this amazing new website named nupinch.com…i really think you guys should check it out..
Link: http://bit.ly/XczfI3
August 28 2014, 03:46AMIt's very useful blog your site thanks provide blog commentshttp://www.myindiatourism.com All visitor use to check domain

subset: commoncrawl


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When it comes to education, there are a countless number of students who are determined to study hard, get an outstanding grade, and use the knowledge they have learned in order to apply it to real life scenarios. No matter how great you are at playing the role of a student, there are still times when you will have to tend to other aspects of your life. Perhaps you have to go to the doctor for a check-up, get together with family that you haven't seen for a while, or finally buy that dream house you have always wanted.
Trying to juggle so many aspects of your life unfortunately means you will someday have to miss a critical lecture. Even if you attend all your classes, you still have the potential to have your mind wander during that three hour lecture, which for whatever reason starts at seven in the morning. You could stress out and desperately try to get notes from your classmates or make an appointment with your Course Director to review the material. Could there be another way of dealing with this situation?
To help relieve some of the anxiety of missing a class or just simply missing a crucial piece of information during a lecture, many schools started to look to lecture capture systems as a solution. A lecture capture system is designed to have a camera record the audio and video of the instructor, and the displayed content of the lecture. All of this is then uploaded to the Learning Management System (Blackboard), allowing the students to watch the lecture on demand.
The Icahn School of Medicine at Mount Sinai has lecture capture (Echo360) system cameras installed in various rooms in the Annenberg and Hess buildings.
Davis Auditorium
Seminar Room A (Floor 2)
Seminar Room B (Floor 2)
If you ever find yourself in the Levy Library, take a look around and observe some of the students. You might spot some of them watching a recorded lecture. The popularity and the demand for these recorded sessions are growing and the vision to utilize the system is expanding. For the past four months the Instructional Technology Group (ITG) has been working on upgrades that will substantially enhance the usability of the system. Some of the upgrades you will notice are:
- The branding at the top of the lecture capture player;
- A capture will now be available as fast as two hours after the lecture has concluded;
- A software version of the lecture capture system is now available for your laptop. As an instructor, this means you can create recorded lectures in your office on your laptop and distribute them as lecture captures through Blackboard;
- The ability to view lecture captures from a laptop or mobile device.
Medical Education and Graduate School lectures are not the only materials being recorded. Currently, we have over 60 courses and programs using the lecture capture system. There have been various events and programs that have benefited from having their sessions saved and displayed to the students and faculty. These include:
- Bench to Bedside
- EHHOP Grand Rounds
- The Fellowship Core Conference
- speaker panels and trainings
- the Summer Enrichment Program
- and the USMLE Program
During 2014, our lecture capture system has recorded and produced 596 videos between the months of January and May. In 2013, we obtained 456 videos during the same 5 month span. We can see that the numbers have increased and I predict the number of captures will continue to increase, further helping the students and course directors that use it. In this regard, we should grow along with lecture capture and utilize it as best we can.
"In a Fall 2010 another lecture capture company, Tegrity, Surveyed 6,883 college age and adult higher education students, a total of 85% stated that having access to recorded lectures made study somewhat or much more effective than normal." Greenberg, A. D., & Nilssen, A. (2011). Lecture Capture Deployment Models
"Wainhouse Research has stated elsewhere that lecture capture is today – and will remain for the foreseeable future – one of the hottest campus technologies for higher education. We have identified certain trends through conversations with colleges and universities – many of whom are clients wrestling with how to scale – which involve the need to address mobility, data, customized learning, and scalability." Greenberg, A. D., & Nilssen, A. (2011). Lecture Capture Deployment Models


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|This article is written from a
Real World perspective.
|Light Cycle: CLU Zero Gravity R/C
|Spin Master
|Release Year
|Based On
|Light Cycle
The CLU Zero Gravity Light Cycle is a toy manufactured by Spin Master. It is remote-controlled and has the capability to move up walls or slanted surfaces and must be recharged frequently.


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matkinson needed a new logo design and created a contest on 99designs.
A winner was selected from 107 designs submitted by 34 freelance designers.
The current brand name is Approvr. See http://www.approvr.com. The company is rebranding as proofHQ. We require a new logo for proofHQ.
ProofHQ or proofHQ
Proofing and approval made easy
Desired Color Scheme:
See existing logo
Accepted File Formats:
Standard Web Formats (.jpg, .gif or .png); Vector Formats (.eps, .pdf or .ai); Layered Formats (.psd or .tiff)
The new logo for proofHQ should use the same colour scheme as the old Approvr logo, although you can get creative and introduce some new colours if you want.
We want the new logo to be suitable for a creative client base (most of out clients are designers and marketing people), but also have a sense of purpose and process. The application is about managing the proofing process after all...."This is the place where you can manage your clients, get their feedback on your work and make sure that they give their feedback on time".
The logo needs to work well on a black background and a white background.
You can get the current logo here http://www.approvr.com/dashboard.ph…441894_134
Find out how a design contest works or learn more about our logo design services.


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Nominate Your Dock Mate for Houseboat Magazine's 2008 Houseboater of the Year
Know someone deserving of the coveted "Houseboater of the Year" title? Maybe you're thinking of that dock buddy-you know-the one that always has the right tool in a pinch and is always the first to offer a hand. Or, is it that lovely couple a few slips down who go out of their way to make sure everyone is invited to the dock parties? The Houseboater of the Year embodies the spirit of what we do, serves as an advocate for the community and knows how to have a little fun along the way.
Send your nomination in-they can't win if you don't nominate them.
Send the information requested below to us via email, fax or post at:
Houseboat Magazine
Attn: Houseboater of the Year
360 B Street
Idaho Falls, ID 83404
Fax: 208-522-5241
All nominations must be received by January 15th. All submitted material becomes the property of Harris Publishing and will not be returned unless prior arrangements have been made.
Note: Employees of houseboat manufacturers are not eligible to win.
A potential Houseboater of the Year must:
1. Serve the houseboating community through advocacy and example. (What specific contributions has this person made to his/her dock, marina or houseboat club? How has this person promoted houseboating to the non-houseboating crowd?)
2. Be a long-time houseboater.
3. Own his/her own houseboat.
Phone Number(s)
E-mail Address
Mailing Address
Name of Houseboat
Make and Year of Houseboat
Location Where Houseboat is Moored
No. of Years as a Houseboater
Relationship to Nominee
Describe in 500 words or less why this person meets the requirements listed above. Be descriptive and convincing, because the better you write, the better the chance the nominee will win! Please include photos of your nominee. If they are selected, their story will be featured in the 2008 "Luau in Louisville" Expo Program.
Submissions must be received by January 14th, 2008 for consideration
Like what you read?
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When I started working on genealogy, I had my grandparents' names and virtually nothing else. It took some work and a lot of luck, but I was very fortunate to soon find other researchers who had been working for years and had all purposefully put their data online or published it in society newsletters, etc., to make it easier for others to find. I think of their generosity whenever I meet genealogists who proudly proclaim they don't share their work. I understand, and have had those thoughts myself..., but I know my research wouldn't be as far along as it is now without the help of others before me.
Line of Descent
John Hughes = Lydia Cooper
Charles Causier = Catherine Hughes
John Henry Carr = Ann Matilda Causier
Grandma, Bertha Maud Carr
FHL film # 350,620: Pre-printed forms, film starts at p. 230, goes to 300, and then starts over at #1 in about April. Catherine's baptism is on the page numbered 64. Unfortunately, Catherine's is one of the many which have only a baptism and no birthdate.


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Finally Friday is here and December is just around the corner. Can't wait to get into the Christmas spirit!
The weather got a little better these couple of days, that doesn't mean it's not cold, but I am still able to get out and take outfit pictures without freezing! There are now officially only two weeks of tutorials and lectures left and then relaxation.. Well, not exactly, a lot of hand-ins are due in January, but at least I don't have to go to Uni.
I am wearing:
Blazer - H&M
Top - Primark
Skirt - Missguided
Tights - Primark
Boots - New Look (similar here)
Bag - Primark
Watch - D&G
Rings - Claire's and Warren James


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debiler wrote:Man, I'm so bummed out! I had an awesome game last night with Dallas against OKC. Westbrook was ripping through the defense all game long until he fouled out mid 4th quarter. With him out, I came back from a 14 point-deficit and cut their lead to 3 with about 12 seconds to go, but no timeouts. So naturally, I foul Maynor who surprisingly misses both free throws. Marion grabs the board, passes it to Kidd who paces down the court. I make a quick hesitation move and penetrate to the rim when I notice Dirk making a beautiful cut through the zone, using an off-ball screen by Marion and heading for the arc. Imagine the gleeful smile on my face. The clock is down to 2 seconds when i pass the ball to Dirk. AND WHAT DOES THE STUPID FUCKER DO??? While the pass is in the air, he stops running towards the three-point-line just a foot short. When he catches the ball, I desperately try to reach three point land, but it's about 0.5 seconds too late when he shoots ( and -to add to my frustration- makes ) the 3. Seriously, WHAT THE FUCK!? I thought that momentum was so important in 2K12. Then why in Jesus H. Christ's name does the guy awkwardly stop running when he doesn't even need to? My timing on the pass was spot on. If everything would have gone like it should have (I've been doing those in-and-outs a lot lately, works like a charm), I'd have been fine with just missing the shot and therefore losing the game. But this is bullshit. I swear, this game will never stop fucking with me.
Rant over. I still love 2K12 with growing passion, but it's moments like this that make me wonder why I don't just play the Sims 3 instead.
Haha, that sucks. One day 2k will fix this
I wonder though. Doesn't the Sims 3 have similar flaws?


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Retaliation Complaint - Whistleblower Law for State of Wisconsin Employees
Document Number: ERD-13859-E
Description: This form should be used to file a Complaint of Retaliation under the Whistleblower Law for state employees.
Comments: This form must be signed by Complainant or authorized representative.
Content Contact: Equal Rights Information
Document Attachments:
ERD-13859-E (Electronic Version - Word/86 KB)
ERD-13859 (Print Version - pdf/29 KB)
*** If you need to access this form in an alternate format, please send an email to the Content Contact listed above.
*** Should you require the necessary software to view the above attachment, please go to the DWD Viewers Download Page. Links to each specific vendor's site have been provided for you. Thank you.


text:
Two specialized membranes, both of which are phospholipid bilayers, encircle each mitochondrion present in a cell. These membranes effectively compartmentalize the organelle into a narrow intermembrane space and a much larger internal matrix, and each contains a distinctive array of proteins that are associated with their functions. The outer membrane of a mitochondrion, which acts similar to a sieve, includes numerous copies of the channel-forming protein porin and is impenetrable to molecules greater than 5000 Daltons in size. Most of the molecules that are small enough to pass through the outer membrane are impeded by the more-selective inner membrane that is typically highly convoluted so that a large number of infoldings called cristae are formed. The inner membrane contains an array of transport proteins that render it selectively permeable to molecules that need to move into and out of the matrix, and also possesses a large amount of the phospholipid cardiolipin, which makes the lipid bilayer particularly difficult for ions to penetrate. In addition, proteins embedded in the inner mitochondrial membrane are essential for oxidation reactions and the generation of adenosine triphosphate (ATP) in the internal matrix.
The log phase monolayer culture of African water mongoose cells depicted above was treated with MitoTracker Red CMXRos in growth medium for one hour, washed, and fixed with 3.7-percent paraformaldehyde in medium containing serum. After washing and permeabilization, the cells were blocked with bovine serum albumen in PBS and labeled with BODIPY FL conjugated to phallacidin. The nuclei were subsequently counterstained with Hoechst 33258. Images were recorded in grayscale with a QImaging Retiga Fast-EXi camera system coupled to an Olympus BX-51 microscope equipped with bandpass emission fluorescence filter optical blocks provided by Omega Optical. During the processing stage, individual image channels were pseudocolored with RGB values corresponding to each of the fluorophore emission spectral profiles.
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Poland backs away from EU software patents push
The European Union's bid to adopt a proposed directive on software patents has been dealt a blow with Poland refusing to back the proposal in its existing form, according to a statement issued jointly by the NoSoftwarePatents campaign, the non-profit Foundation for a Free Information Infrastructure and the Internet Society Poland.
In May, Poland voted with the Council of the European Union to approve the "Patentability of Computer-implemented Inventions" directive.
However, in a statement on Tuesday, the Polish cabinet said that after consultations with professional IT bodies and its patent office, it had concluded that the proposed directive would not achieve the stated goals of limiting patents on software and business methods in Europe.
It said it would "definitely" support "unambiguous regulations" but not a directive under which the functionality of computer programs could be patented.
The NoSoftwarePatents campaign was set up earlier this year by 1&1, part of the United Internet group and a publicly traded German company, Linux vendor Red Hat, and database vendor MySQL AB, Europe's largest open source company.
The statement said the EU Commission and governments of other EU member countries claimed that the legislative proposal would not allow the patenting of programs that run on the average PC.
However, NSP said, at a meeting hosted by the Polish government on November 5, representatives of the Polish Patent Office, SUN, Novell, Hewlett-Packard and Microsoft, as well as various patent lawyers confirmed that the present proposal did make all software potentially patentable.
Without Poland's support, countries which supported the proposal in May now fall short of a qualified majority by 16 votes. New voting weights took effect in the EU on November 1.
The directive was presented to the European parliament by the European Commission in February 2002. MPs then included amendments against software patenting in the directive.
The reintroduction of software patenting was done by the Council of Ministers and this version of the directive was passed.
A final vote on the directive will take place later this month or in December. Belgium has abstained from the process but even if it decides to vote for the directive, Poland's opposition would ensure the directive will stall. Under the new weightage system, Belgium has 12 votes.
The directive has come in for criticism from many quarters, with Deutsche Bank Research and PriceWaterhouseCoopers warning of the negative consequences to European IT companies, to innovation, and to the ability of the EU to achieve the goals set out in its Lisbon Agenda.
In July, the Dutch parliament passed a resolution that its government change the position of the Netherlands from support to an abstention. And last month, all four groups in the German parliament spoke out against software patents and the legislative proposal in question, and introduced different motions to that effect.


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Tough Shit: Big Media Need To Do SEO Too.
Big Media "Wants" Top Organic Placement From Google? Get in Line.
Matt McGee's article on Search Engine Land on March 23rd was as enlightening as it was infuriating. Here's the gist:
…several big brand media companies who, according to an [AdAge], have told Google they deserve higher rankings in Google's search results. Not only that, but one executive has also labeled the rest of the content-producing web — including bloggers like us — as "parasites" who "benefit disproportionately" from Google's ranking algorithm.
Big Media/Big Publishing Banked Too Heavily On Branding
I'm sorry to hear that. This is no one but Big Media and Big Business's fault in the first place. For years they've resisted search engine optimization (SEO), banking heavily on brand recognition and brand management to garner the links and do the heavy lifting. As if people will naturally want to link to them, after all, they are the preeminent authority. And, from their point of view, I can see where that line of thought is, to certain extent, useful. But, as noted by nearly every search marketer in the past 5 years, Google controls search; ergo Google makes or breaks brands. And, apparently, with all the money Big Media/Big Publishing are kicking into the kitty, they'd like a little "more" assurance that they'll be "taken care of". Back to Matt McGee for the list of demands:
The big media companies' complaints include:
- Google's search algorithm in general, which they say "penalizes paid content"
- PageRank specifically, because it places too much of an emphasis on links
- The appearance of Google's search results, which hurts big brands because every result looks the same
How To Read The List of "Demands":
- We don't expect to penalized if we decided to keep our content under lock and key (read as password protected/subscription). We expect to be exempt from that rule. Accordingly, we expect that all other smaller publishers will have to abide by the rule: that is Google will not be able to fully index that content. Additionally we don't want to have to take into account any sort of architecture issues or usability issues with our websites (such as excessive use of javascript or flash), please just push us to the top of the list.
- We'd like for PageRank to matter, but specifically for our sites create an algorithmic change which will ignore inbound links. The only thing we expect PageRank to take into account for our sites is our content and keyword relevance/density and authority/trust. We can't be bothered with learning how to market our content and products effectively, or strategically.
- We don't like that all the results for a given query look nearly identical. Since we provide a greater share of the monies, we'd like to have our results highlighted in a day-glo orange with flashing lights around it. Alright? Great. And, of course, we'd like a larger font size and a unique font for only our news sources. We expect all other results to have exactly the same font size and format.
What Will Google Do?
Do I expect Google to give in to all these demands? No. Do I except some concessions to be made? Of course. If the "Fat Cats" (i.e. The New York Times, WSJ, Time Inc, Hearst, ESPN, etc.) are unhappy, then you lose profit. If you lose profit, your stock value decrease (even more than it already has), and no one is happy. As Matt mentioned, the Vince Algorithmic change, was pretty much instituted for the large brands to ensure they show up within the SERPs for more general queries, like "soda pop".
That's a pretty big concession already. Small/Medium sized businesses have been working for years with SEO firms to rank well for general and semi-general keywords. And, in one fell swoop, Google essentially erased that work without so much as the big companies having to do a lick of acutal optimization. Now, faced again with the same issues, the big companies are being a bit more brazen. I doubt there was an actual threat in the Google's Publishers Advisory Council meeting, but there were more than likely overtones and half-measures tossed around that indicated if Google didn't "right this wrong", dollars will be pulled.
How much more can small/medium businesses endure before Google ultimately kowtows to Big Media/Big Business? Big Business already got an algorithmic change to favor them for "general queries". Now they want the long-tail too. My answer to that: TOUGH SHIT. DO SOME SEO TOO.
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Event details
- 23 December, 2018
- 10:30
The worship service on Sundays start at 10:30, is a time of worship in song and teaching where you will find a variety of people who are rediscovering the contemporary relevance of the Christian faith and message for themselves and their families. Children's Sunday school takes place simultaneously. We look forward to meeting you and having you join in our vision of hope and service.
A children's programme is offered to coincide with the sermon for all children from age 2 to 5th grade. We use teaching material supplied by Scripture Union. Children are placed into age appropriate classes and all children study the same Bible lesson.There are also action songs and craft activities. A crèche is available for 0 – 2's from 10:30 – 12:00.


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Friday, May 11, 2012
Handspun Friday - Shipwreck & Longest Night
and Longest Night:
Both are superwash Cheviot, new to me fiber. As soon as I took it out of the bag, and handled it, I knew it would turn into something other than a garment or anything else near the skin. It was just too rough for my taste.
Spinning it was super easy, but there were a lot of coarse hairs to be picked out, which I did in the beginning, and eventually let some of them go.
I also knew, that I wanted them to be together. I spun a 2-ply yarn from each colorway, and plied them together to get a cabled yarn. 279yds total.
Now, what to do with it? I loved how it looked, but was pretty scratchy yarn. I decided to make some kind of container with it. I haven't done any crochet in a long time, and I'm happy to report, that my hands could handle the whole bag without too much pain. Well, yes, I made a drawstring bag.
Here it is! I love it! Open:
and closed:
I asked Denny to come with me to do a photo shoot!
Nudge, nudge!
His payment was in the bag. :o)
And here it is on my desk.
This was a fun, fast project. I started out with this pattern, but modified it. I really like the look of single crochet, it's almost like woven. The base is not really round
I could have made it round, but I was following the pattern. The base is 6 1/2 inches. Then I crochet up for 7 inches, did the eyelet to get the leather bands through, and after that crochet another inch or so using a 4mm hook. I'm quite happy with it.
Wishing you all a lovely weekend!
♥ ♥ ♥
24 comments:
- illusions said...
Denny is the best model ever. LOL! Love the bag, something I would really like to show off kind!
- May 11, 2012 2:04 a.m.
- kreativa said...
danke für die ausführliche Beschreibung und die tollen Bilder. Der Beutel ist wunderbar geworden. Das werde ich auch mal versuchen. Liebe Grüße von Ate
- May 11, 2012 2:29 a.m.
- Sometimes Unwilling Guru said...
You clever girl,that is so gorgeous,it gives a better idea what to do with some coarse fibre sIve had in my stash.I wan to rejoin SCF but theres a rather long waiting list!!
- May 11, 2012 3:52 a.m.
- Bea said...
Die Tasche würde mir auch gefallen :-)
Liebe Grüße, die Bea
- May 11, 2012 4:03 a.m.
- Knittynutter. said...
great spinning and i LOVE that bag....
- May 11, 2012 4:14 a.m.
- Freyalyn said...
Denny's coat looks so fabulously shiny and healthy here - I bet he sheds tremendously! And a lovely bad - the way the copper bits just pop out is very pretty.
- May 11, 2012 5:34 a.m.
- Wooly Knits n Bits said...
What a great idea! It's really beautiful. I never know what to do with the coarser yarns and now I do.
- May 11, 2012 7:32 a.m.
- monica said...
I love the bag! Denny is so cute!! :)
- May 11, 2012 8:49 a.m.
- Fluffykira said...
I saw this over in the SCF thread, but I think it's a great use of the yarn. So pretty!
- May 11, 2012 10:52 a.m.
- Ruth said...
Goofy doggie!
- May 11, 2012 10:59 a.m.
- Erica said...
Beautiful bag! I always have so much fun watching your spinning posts. It's so interesting to see how fiber transforms on spinning, and then again with knitting/crochet. =)
- May 11, 2012 11:19 a.m.
- Carrie#K said...
Have a good weekend! Denny is a very thorough model!
- May 11, 2012 2:05 p.m.
- Hélène said...
Simply gorgeous! And really inspiring...
- May 11, 2012 2:49 p.m.
- Susan said...
That was the perfect use for that yarn!
You know I'm not a fan of the color orange but you always manage to make it look beautiful!
- May 11, 2012 4:07 p.m.
- Wanderingcatstudio said...
LOVE, LOVE, LOVE the bag. I want one!
- May 11, 2012 5:11 p.m.
- Virginia said...
Lovely yarn and lovely bag. Georgia and I were cracking up at the pictures of Denny sticking his head into it.
- May 11, 2012 5:49 p.m.
- Spunkyarn said...
What a lovely bag! :) stunning colours
- May 11, 2012 7:41 p.m.
- Walden said...
I love the way you pair things together. I would have never looked at those two fibers and thought to join them, but I love how they look in that bag!
- May 12, 2012 10:12 a.m.
- Rhonda said...
Oh, that bag would be perfect for sock projects. I've saved it. Thanks for the link.
- May 12, 2012 10:48 p.m.
- Lynn One, Purl Two said...
- May 12, 2012 10:58 p.m.
- Sharon V said...
Wow, I love that bag! I never thought of making a bag with my scratchy yarn, but I will now. Great job
Happy Mother's Day to you.
- May 13, 2012 5:39 p.m.
- Stephanie said...
Seems like this would be a useful item and I really like the pewter sheep pin! (sjn821)
- May 17, 2012 11:23 a.m.
- 2paw said...
You did make a silk purse out of a sow's ear!! What a great bag and I love Denny's help He's so funny!! I hope there was a treat in the bag???
- May 22, 2012 3:22 a.m.
- Amina O. und ^^ Paul the Cat said...
Hi from the old world, Monika! Your great bag was part of my Hello Friday post of today and when I found your story just now about Bag And Benny I added a picture with him. Ein schönes Wochenende allen Tieren und Menschen, Amina.
- February 08, 2013 7:01 p.m.


text: CABE´LLIOCABE´LLIO (Καβαλλίων, Strab. p. 179: Eth.Καβελλιωνήσιος, Eth. Καβελλιωνίτης: Cavaillon), a town in Gaul, on the Druentia (Durance), and on a line of road between Vapincum (Gap) and Arelate (Ailes). Stephanus (s. v. Καβελλίων), on the authority of the geographer Artemidorus, makes it a Massaliot foundation. Walckenaer (Gëog. &c. vol. i. p. 187) says that M. Calvet has proved, in a learned dissertation, that there was a company of Utricularii (boatmen, ferrymen) at Cabellio, for the crossing of the river. Such a company or corpus existed at Arelate and elsewhere. Cabellio was a city of the Cavares, who were on the east bank of the Rhone. Pliny calls it an Oppidum Latinum (3.4), and Ptolemy a Colonia. It was a town of some note, and many architectural fragments have been found in the soil. The only thing that remains standing is a fragment of a triumphal arch, the lower part of which is buried in the earth. In the Notitia of the Gallic Provinces "civitas Cabellicorum" is included in Viennensis.


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Enterprise Resource Planning | News
Oklahoma State University is upgrading its enterprise resource planning (ERP) system in an effort to improve student experience and reduce operational support.
The university is adopting Ellucian's Banner to allow students "to personally manage their academic careers while remaining in close contact with their institutional advisors," according to a news release. "Banner will also present Oklahoma State University faculty with an opportunity to improve data collection, strengthening the institution's ability to make critical decisions."
Students will use Banner Student to apply for admission, enroll in classes and access financial aid information. The school will also implement Ellucian Mobile, Ellucian Portal, Banner Financial Aid and Banner Data Defense.
"For more than 120 years, Oklahoma State University has been guided by a specific principle – to facilitate student experiences that promote future achievement," said Oklahoma State University CIO Darlene Hightower, in a prepared statement. "We want to engage with students on a meaningful level — both academically and socially — through technology that mirrors their communications in everyday life. Partnering with Ellucian will help drive those experiences and connect us with our students more effectively."
More information is available at ellucian.com.
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Joshua Bolkan is contributing editor for Campus Technology, THE Journal and STEAM Universe. He can be reached at firstname.lastname@example.com.
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He was only in Hershey, Pa., for a quick visit in late August, but Scott Eatherton wanted to get some work in, so he called up his high school coach Tim Bean.
It wasn't unusual for Bean to see Eatherton's name on his phone.
They had been tight since Eatherton's days at Hershey High School.
When Eatherton went to St. Francis University about three hours away, they talked.
When Eatherton decided to transfer to Northeastern last year, Bean guided him through it.
Even when Eatherton sat out the mandatory season after making the switch, he made sure to shoot texts to Bean. When the Huskies reached the Colonial Athletic Association tournament last season, Eatherton shot Bean a text message to make sure he was watching the championship game.
Popping in for a late-summer workout might not be normal for some players, but it is for Eatherton, Bean said.
"I don't know how many kids come home for a week at the end of the summer and say, 'Hey, I'm going to get in the gym with my high school coach, just him and I, three, four times,' '' Bean said.
Before that, it had been a while since Bean had seen Eatherton. He could remember when Eatherton was still trying to grow into his body.
"For years, he would run and he would be kind of gangly and a little bit awkward and you could see the flashes where he had the nice hands and the nice touch," he said.
Bean was caught off guard when he saw the 6-foot-8-inch, 219-pounder walk in.
"I was like, 'Oh my god, look at those shoulders,' " Bean said. "I was just amazed at how big he was."
But as long as Bean has known Eatherton, improving has been at the core of everything the player has done.
"He's gotten better and better every year," Bean said. "He's grown into his body, now you see how well he runs and how well he moves.
"I think he'll be the first to tell you, he wasn't the most successful when he was younger, but he just continued to get better and better each year.''
In seven games this season, Eatherton has made an immediate impact, posting five double-doubles. He's gone for 20 and 12 twice (Stony Brook and Charlotte) and averaged 18.3 points and 12 rebounds in the Puerto Rico Tip-Off, earning CAA player of the week honors.
Looking back at their workouts this summer, Bean said it wasn't surprising. "I was so amazed at how be keeps progressing,'' he said.
Eatherton averaged 18 points and nine rebounds as a junior at Hershey, then the next season averaged 18.6 and 11 and led Hershey to a division title.
"He kind of blew up and it was like, 'Wow, he's a stud, '' said Bean.
Eatherton slowly noticed the changes himself.
"I was able to do things like jump higher, run quicker, get rebounds more often," Eatherton said. "You don't really expect it. Like, you'll be trying to do some sort of dunk and you won't be able to do it, then the next year comes around, after you've been lifting, running, doing agility drills, and you'll be able to do it. It's just surprising really."
During the recruiting period in July before his senior season, he suffered a broken finger. He had a list of events mapped out, from the Hoop Group camp that was supposed to be flooded with recruiters, to AAU tournaments, but he made only one.
He committed early to St. Francis. Bean remembers having another player drawing looks from different schools, and whenever their scouts would drop by practice, they would look at Eatherton and say, "Man, that's a good get for St. Francis.''
As a freshman, Eatherton played just under 10 minutes a game, averaging 3.9 points and 2.1 rebounds.
His sophomore season, injuries depleted St. Francis but put Eatherton in a position in which he became the team's go-to player. He went from being a role player to constantly looking to score.
"They needed someone to step into that role," Eatherton said. "That kind of helped me try new things shooting-wise, driving by people, stuff like that."
Putting up 14 points and seven rebounds a night, he earned the Northeastern Conference's most improved player award.
But when St. Francis fired coach Don Friday in 2012 after four seasons, Eatherton started thinking about his own future. "It was difficult," Eatherton said. "I was close friends with a lot of guys on the team, but I just thought I could have a better opportunity someplace else."
The way things work in the recruiting process, the degrees of separation are usually slim. Bean got in touch with Northeastern coach Bill Coen through a mutual friend. , Tilton school coach Marcus O'Neil, who went all the way back to youth basketball with Bean
"When you bring up Coach Coen's name, everybody talks about how great of a guy he is," Bean said.
Now, a Huskies team that was guard-centric a year ago when it came just a win away from an NCAA Tournament berth, plays through the post with Eatherton and 6-7 junior forward Reggie Spencer.
Eatherton commands attention on both ends. "He does such a great job of anchoring our defense, protecting the rim with either blocked shots or defensive rebounds," Coen said. "And then on the offensive end, he usually gets extra attention. , which allows more space on the perimeter for our guardsWhen you have a player like him, people recognize him and they game plan for him and I think that helps everybody."Julian Benbow can be reached at email@example.com.


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This healthcare market continues to grow as healthcare shifts from the hospital to the home. Like many healthcare professionals, these workers need to speed up patient encounters, while providing better care.
Providers also face the added challenge of being constantly on the move. Fortunately, home health agency software is designed to automate many of the day-to-day activities professionals encounter, including:
We've created this guide to help buyers better understand this software market and how to identify which systems will best meet their needs.
Here's what we'll cover:
Reviewers' Choice
What Is Home Health Software?
Common Features of Home Health Software
What Type of Buyer Are You?
Market Trends To Understand
Deployment Strategies
Recent Events You Should Know About
Reviewers' Choice Products
|Alora Home Health
|Brightree Home Health
Our Reviewers' Choice list shows the five highest user-rated software solutions for Home Health when adjusted for total number of reviews and recency of reviews.
If a software solution has more reviews, and more recent reviews, we value those ratings more highly than a product with fewer, older reviews. This is because is it much harder to get 100 five-star reviews than it is to get 10.
We also know that software vendors continually tweak and update their product, so we believe that more recent reviews tend to be more accurate.
To determine which products made the final cut, we looked at how users rated each solution's:
A solution can make the Reviewers' Choice top five in all three categories, or just one or two. All software solutions in the Reviewers' Choice have at least 10 reviews from real software users. The final products are listed in alphabetical order from left to right.
For more details on how we selected our Reviewers' Choice, read the full methodology.
It generally includes features typical of most electronic health records (EHRs) to streamline the day-to-day clinical operations of providers. More specifically, these systems have been designed to automate nearly every process needed in home care—ranging from clinicals, or point-of-care records, to billing, scheduling and accounting.
Most systems are designed to take you through the Home Health Care Outcome & Assessment Information Set (OASIS) while keeping patient data secure and HIPAA-compliant.
Some systems offer unique features designed to meet the needs of specialty areas, such as physical therapy, occupational therapy, speech-language therapy or others. (For more information about software designed for other post-acute care settings, check out our long-term care and nursing home software guide and our assisted living software guide.)
|Point of care
|Assists in conducting and capturing information from OASIS assessments and in determining a Plan of Care. Helps with completing HCFA-485 forms, OBQI reports and HHRG scoring. Stores notes from home aides, hospice, therapists and information on patients' vitals. Functions include internal messaging, medication interaction checks, mobile device and telephony support and infusion therapy support. Also features signature capture, physician portal, ICD-9 database and HL-7 interface.
|Home health billing software manages eligibility verification, claim scrubbing and CMS-1500s. Includes case mix calculator and non-LUPA case adjustment. Functions include ERN posting and electronic remittances, secondary payer support, request for anticipated payment (RAP) support, collections management, billing services and UB-04 support.
|Home health scheduling software manages the process of scheduling patients to ensure accuracy of daily calendars. Features include conflict alerts and wait lists.
|Automates accounting procedures for agencies. Functions include payroll, general ledger, purchase orders, accounts payable and inventory control. Also handles bank reconciliation, accounts receivable, fixed asset management and budgeting/forecasting.
|Human resources (HR)
|Assists in routine activities including healthcare provider background and security checks, tracking time and attendance and payroll. Handles I-9 forms, certification tracking and review management.
|Customer relationship management (CRM)
|Helps coordinate care of patients across specialties, departments and locations, improving the impact of your referral program. Aids with correspondence related to wait lists for hospices with limited space and to donor management for organizations receiving charitable contributions.
Aide plan of care in Alora Home Health
Before evaluating software and lining up a formal comparison of systems, you'll want to make sure you know what type of buyer you are, and which home health software vendors meet your needs. We've found almost all buyers fall into one of the four categories listed below:
Home care. These agencies provide care by licensed health workers—including registered nurses, licensed practical nurses and licensed therapists—to treat patients for illness or injury. The most important features of home care management software for these agencies will likely be the clinicals (also called point-of-care records) and scheduling features to help you monitor your patient census. Most agencies will also require applications such as human resources, accounting, billing and customer relationship management. Therefore, integrated suites are ideal for these buyers.
Hospice care. These organizations will often look for human resources and customer relationship management systems. These features help support communications with volunteers and philanthropic donors that help the organization either financially or with in-kind contributions. Human resources features are important for conducting tasks, such as background checks of workers, payroll and performance reviews. Some organizations may prefer software tailor-made for hospices; see our hospice software buyer's guide for those options.
Private duty. These buyers typically provide non-medical care and require software that can support billing to organizations other than Medicare. They oftentimes also require human resources, scheduling and accounting solutions.
Therapy/rehabilitation. Therapeutic care providers, such as speech therapists and physical therapists, often look to systems to help manage patient data and track therapy progress. Other common needs include ensuring compliance, scheduling, therapist productivity and managing accounts receivable.
Buyers should keep the following trends in mind when researching software. How a vendor fits within these trends can affect its viability.
Software as a Service (SaaS). The growth of cloud, or Web-based, computing practices has touched many industries and healthcare is definitely among them. Within healthcare, home care-centered agencies can appreciate the lower upfront costs of home healthcare software, monthly pricing model, lack of IT infrastructure and remote accessibility that Web-based applications can deliver.
Accessibility from mobile devices. Web-based home care solutions provide convenient access to patient data from mobile devices, such as an iPad, iPhone or Android. This improves your efficiency and reduces paperwork by helping you complete assessments directly at the point of care.
Quality assurance features. Given the prevalence of mobile devices, it can be increasingly important that a point-of-care system automatically generate a Health Care Financing Administration (HCFA) form following completion of an OASIS so that payment from Medicare is assured.
When selecting a solution, buyers can choose to implement applications for specific tasks—known as standalone, best-of-breed home healthcare solutions. Or, they can go with an integrated system that has a full suite of tools to address all of their needs—such as accounting, billing, human resources and more.
Agencies also need to determine how they would like to access the system. For example, some systems are offered completely over the Internet as Web-based home health software systems. This is also referred to as a software-as-a-service (SaaS).
These SaaS systems are typically offered in a pay-as-you-go monthly or annual subscription and are hosted and maintained by the vendor. Other vendors offer on-premise solutions where users install and run the system from a server at your agency. It's important to note that many vendors today offer both SaaS and on-site systems.
Home health market predicted to grow to $11 billion. A 2016 study by Stratistics MRC predicts the global home healthcare software and services market will be worth $11.2 billion by 2022. Factors contributing to this growth include the rising geriatric population and the number of products and services being developed to address their needs.
Homecare Homebase and Samsung team up. In December 2016, home health software vendor Homecare Homebase (HCHB) announced a collaboration with Samsung. HCHB's platform will be available on more than 140,000 Samsung Galaxy Tab E tablets to help mobile users manage workflows, revenue and resources.
Home health market gets its own voice assistant tool. In December 2016, vendor Orbita released its Voice Experience Designer tool. Similar to the Amazon Echo voice platform, this tool leverages artificial intelligence and relies on voice commands to perform tasks. It is specifically designed to help home health patients by offering applications to monitor medication/treatment adherence, caregiver coordination, pain management and more.
Our service is simple and 100% free to customers like you because software vendors pay us when we connect them with quality leads. You save time and get great advice. Vendors get great referrals. It's a win for everyone!


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Uncle Sam and Road Construction Man
Happy 4th from Uncle Sam and Road Construction Man. These two were spotted earlier this year when our rouleur ride with a climb ended at the start of a parade. Also see another Uncle Sam on a Tall Bike and why 'merica is great!


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- Inside Athletics
- Tickets
- Fan Zone
- Media Zone
- Social
- Shop
- Donate Now
As a student at East Tennessee State University, Mark Newland remembers waking up on Saturday mornings during the fall semester with only one thought.
"What letter will I paint on my chest today? That was really the first thing I would think about, and then it would be the anticipation of getting ready for the football game and heading to the Dome," Newland said.
Having attended ETSU from 2001 to 2005 and graduating with a degree in broadcasting, Newland was fortunate enough to enjoy three years of ETSU football before the program was disbanded following the 2003 season. During those years, he was a member of a student spirit organization called the SCUBS (Bucs spelled backwards), a group known for their ardent support of the Bucs and their propensity to "paint up" before games.
As the Buccaneers prepare to reboot the program in the fall of 2015, Newland counts himself as one of those who will be emotionally moved on the day the Blue and Gold once again run onto the gridiron.
"I will probably lose it to be honest with you," said Newland, who today is a disc jockey for WXBQ-FM, the area's highest-rated radio station. "I'm sure it will be a sellout crowd and the atmosphere will be unbelievable."
Newland is not alone in his excitement for the sport's return. Football alumni Bill Linebarger graduated from ETSU in 1972, and he and his wife, Kathy, have been supporters of the Buccaneers ever since. Even after the program was disbanded in 2003, the Linebargers remained members of the Buccaneer Athletic Scholarship Association, supported the Bucs remaining athletic programs, and quietly anticipated football's return.
"Whether playing or watching football, I've always felt that adrenaline rush right before kickoff," said Bill, whose brother Doug also played at ETSU as part of the famous 1969 Grantland Rice Bowl team. "I'm looking forward to feeling that again at an ETSU game, and just hearing the band play our fight song. There was always something about the echo of the drums that I liked."
As for Kathy, there is no doubt what she will be doing when the blue and gold take the field again.
"I plan to cry," she said.
But the fun will not be limited to those that remember ETSU football's past. There are also new fans that will be seeing the program for the first time.
Landon Owen and his wife Jennifer moved to Johnson City two years ago, and having lived in various college towns and even worked in college athletics, they noticed that something was missing on the ETSU campus.
"We chose Johnson City because – after having lived in a variety of college towns for our entire adult lives – it seemed familiar to us," Landon said. "The biggest difference though between Johnson City and E TSU and those other communities was the noticeable absence of college football."
However, when the decision to reinstitute the football program was made in early 2013, Landon and Jennifer were quickly on board, attending the press conference that announced Carl Torbush as the program's new head coach, becoming Kickoff Fund members, and making a deposit toward season tickets in 2015.
For the Owens family, it's about building community spirit and pride.
"A campus and a community just feel more vibrant, more alive when football is present," Landon said. "When ETSU announced that the program was being revived, we both jumped on board immediately. Jennifer and I could not be more excited to be part of the program and look forward to spreading a new version of Buc Pride throughout town, the region and the country."


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CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00925756
Recruitment Status : Completed
First Posted : June 22, 2009
Last Update Posted : April 2, 2014
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
CCTG 590 is a open-label study to evaluate the impact of therapy intensification with Maraviroc (MVC) (a CCR5 inhibitor) to a stable suppressive HIV antiretroviral regimen on the rate of CD4+ T-cell recovery and gene expression profiles. Patients on a stable first-line HIV regimen with continued viral suppression and sub-optimal CD4+ T-cell counts will be eligible for this study. Those who are found to be eligible will have MVC (dose-adjusted to background HIV regimen) added to their current HIV regimen for 24 weeks. After the 24 week intensification, the MVC will be discontinued, the original antiretroviral regimen will be continued and the subjects will be followed for an additional 12 weeks.
The investigators hypothesize that MVC will improve the rate of CD4 recovery. This improved CD4 recovery will be associated with favorable changes in gene expression profiles of genes involved with CD4 maintenance and circulation.
|Condition or disease
|HIV Infections
|Drug: Maraviroc
|Phase 4
Blunted CD4+ T-cell responses during viral control may be a consequence of on-going T-cell destruction in the regenerative phase of CD4 recovery from activation-induced apoptosis and/or reduced production from decreased thymic output. Maraviroc, a CCR5 inhibitor, may improve the clinical status of HIV-infected by two distinct mechanisms. First, by blocking HIV entry into CD4+ T-cells, CCR5 inhibitors have direct antiviral activity. Second, as the pro-inflammatory state of HIV infection up-regulates CCR5 ligands and receptors, this CCR5 receptor antagonist may abrogate immune activation and resultant T-cell apoptosis. Importantly, MVC binds CCR5 receptors without inducing intracellular signaling or altering cell-surface expression. Potentially, MVC intensification during viral suppression with ART may further decrease persistent activation-induced apoptosis and improve repair and remodeling of lymphoid tissue leading to increased CD4+ T-cell recovery and function.
The aim of this study is to evaluate a potentially therapeutic immunomodulatory effect of MVC. Several measures of immune homeostasis will be determined in this study, including functional genomic analysis and extended T-cell phenotyping. Genes responsive to MVC therapy will be identified and categorized into functional groups. Based upon existing literature of the identified genes and observed immune responses (change in CD4/CD8 subsets) during MVC therapy, a model of CCR5 responsive-genes and potential impact on immune recovery will be outlined. Potentially, individuals experiencing immune discordance during suppressive ART may be better treated by MVC antiretroviral intensification.
1. We hypothesize that expression will decrease among genes involved in immune activation (NF-kB, MAPK, nuclear factor of activated T-cells, MYD88 and STAT1), apoptosis (Fas ligand and TRAIL) and trafficking/repopulation of T-cells (CCR5, MIP-1α, MIP-1β and RANTES) and increase among genes involved in tissue repair (platelet-derived growth factor, insulin-like growth proteins and osteoblast-specific transcription factor).
- The gene expression profiles induced by MVC will be associated with a favorable increase in the rate of CD4+ T-cell recovery.
- The rate of CD4 recovery (cells/month) will be greater during MVC compared to before.
- The proportion of cells expressing activation/ apoptosis markers will decrease from baseline and this decrease will be associated with improved CD4 recovery.
- The proportion of naïve cells will increase from baseline and this increase will be associated with improved CD4 recovery.
- The rate of CD4 recovery will be greater among those subjects receiving PI-containing treatment regimens compared to those receiving NNRTI-containing treatment regimen.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|28 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|The Impact of CCR5 Inhibitor Treatment Intensification on CD4+ T-cell Recovery and Gene Expression Profiles in HIV-Infected Patients With Viral Suppression
|Study Start Date :
|June 2009
|Actual Primary Completion Date :
|November 2011
|Actual Study Completion Date :
|November 2011
Experimental: maraviroc
Maraviroc will be added to patient's existing HIV treatment regimen dose-adjusted to background HIV medications
Drug: Maraviroc
Maraviroc will be given dose-adjusted to background HIV treatment
- Differences in gene expression profiles obtained at baseline and weeks 4 and 24. [ Time Frame: baseline and week 4 ]
- CD4+ T-cell absolute count and percentage at baseline, weeks 4 and 24. [ Time Frame: baseline, week 4 and 24 ]
- The proportion of CD4+/CD8+ T-cell immune activation, maturation, regulatory and apoptosis markers at baseline and weeks 4 and 24. [ Time Frame: baseline, weeks 4 and 24 ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infection
- All available CD4+ T cell counts within the last 12 months of screening below 350 cells/mm3 (minimum of 3 values obtained > 30 days apart).
- HIV treatment with a stable (for at least 6 months) antiretroviral regimen consisting of at least 2 NRTIs and either a protease inhibitor boosted with low dose ritonavir or an NNRTI. A stable regimen is defined as no additions or deletions for more than 14 cumulative days.
- Patient considered to be receiving initial HIV regimen (history of medication substitution for toxicity is allowed).
- All available plasma HIV RNA levels within the last 12 months are below the level of detection. Isolated values that are detectable but < 1000 copies will be allowed as long as the plasma HIV RNA levels before and after this detectable time point are undetectable - The subject should have a minimum of 3 values obtained > 30 days apart.
- Females of childbearing potential must have a negative serum pregnancy test at screening and agree to use a double-barrier method of contraception throughout the study period.
- Men and women age ≥ 18 years.
Exclusion Criteria:
- Current antiretroviral regimen contains tenofovir disoproxil fumarate AND didanosine in combination.
- History of chronic hepatitis C (defined as HCV antibody positive and HCV RNA detectable).
- History of chronic active hepatitis B (defined as surface antibody negative, surface antigen positive and HBV DNA detectable).
- Concurrent use of G-CSF or GM-CSF.
- Prior or concurrent use of IL-2.
- Prior or concurrent use of a CCR5 inhibitor.
- Active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements.
- Use of any immunomodulator, HIV vaccine, or investigational therapy within 30 days of study entry.
- Use of human growth hormone within 30 days prior to study entry.
- Initiation of testosterone or anabolic steroids within 30 days prior to study entry. (Exception: Chronic replacement dosages in patient's with diagnosed hypogonadism is allowed).
Evidence of splenic sequestration or suppressed bone marrow function:
- Clinical or radiographic evidence of significant splenomegaly.
- History of leukemia or lymphoma.
- History of myelosuppressive chemotherapy or irradiation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00925756
|United States, California
|University Southern California
|Los Angeles, California, United States, 90033
|University California San Diego
|San Diego, California, United States, 92103
|Torrance, California, United States, 90502
|Study Chair:
|Miguel Goicoechea, MD
|California Collaborative Treatment Group
|Responsible Party:
|California Collaborative Treatment Group
|ClinicalTrials.gov Identifier:
|NCT00925756 History of Changes
|Other Study ID Numbers:
|First Posted:
|June 22, 2009 Key Record Dates
|Last Update Posted:
|April 2, 2014
|Last Verified:
|March 2014
Keywords provided by California Collaborative Treatment Group:
low CD4 recovery
Low CD4 recovery despite HIV control
Treatment experienced
Additional relevant MeSH terms:
HIV Infections
Anti-HIV Agents
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
CCR5 Receptor Antagonists
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents


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With Alex Rodriguez's decision to drop his Triple Play lawsuits against Major League Baseball, Commissioner Bud Selig and the Players Association, it is extremely possible we have seen the last of the player who one time seemed destined to hold all the records.
In doing so, Rodriguez will accept the 162-game suspension that will cost him the 2014 season and $25 million.
While the reaction of Rodriguez's decision has been positive, speculation is the suit was dropped because he was throwing good money after bad. He would stand to lose $10 million in legal fees.
While I have no doubt Rodriguez did something, nobody has said to what extent. I still call into question Major League Baseball's tactics in the Biogenesis case, which could cost Rodriguez his career.
Rodriguez can return for 2015, and indicates he wants a post-playing career in baseball. Good luck with that … it definitely wouldn't have happened had he followed through with the suit.
Rodriguez will be 40 in 2015, and after being away from the game for a year, one has to wonder how much he'll lose. He could spend the time rehabbing and getting his surgically-repaired hips stronger.
Still, I don't know if it will do any good for his career. The Yankees are obligated to pay him $62 million, but in what capacity?
Will they bring him back and deal with that distraction for two more years, or will they simply buy him out?
I'm betting the latter, thinking we'll never see Rodriguez play another major league game again.


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RWD v Meridian Dan & Bloodline v SBTV v GRM Daily v Link Up v Rio Ferdinand's #5 Magazine
As they compete to win the Court Vs Console NBA 2K15 Playoff on Thursday 9 October.
Following the huge success of last year's NBA 2K14 Playoff and game launch, at which guests were given the opportunity to not only play the amazing game before it's official release, but also to take in some live basketball action from a selection of celebrity teams, while enjoying free food and drink and live DJ performances from some the UK's biggest names.
To celebrate the release of NBA 2K15, the most extensive and engaging game in the history of the NBA 2K franchise, a secret London location will play host to the likes of RWD, Meridian Dan's Bloodline Records, SBTV, GRM Daily, Link Up TV and Rio Ferdinand's #5 Magazine as they compete to win the Court Vs Console NBA 2K15 Playoff on Thursday 9 October.
This year's launch offers a fantastic opportunity to test out the most hotly anticipated NBA game in years and even get the chance win your own copy of the hugely anticipated game, a brand new next generation console to play it on and tickets to see Pharrell at the O2 on Friday 10 October!
With NBA 2K15 due for release internationally on Xbox One, PlayStation 4 and all major consoles the next day, registration is now open to get tickets to the exclusive event to be held at a London location Thursday 9 October.
For our chance to be there click here…
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text:
Fran Lebowitz
Frances Ann Lebowitz (born 1951-10-27) is an American journalist.
- I never met anyone who didn't have a very smart child. What happens to these children, you wonder, when they reach adulthood?
- "Words Are Easy, Books Are Not," interview with Bob Morris, The New York Times (1994-08-10), Late Edition, Section C, page 1, column 1
- There's no such thing as advice to the lovelorn. If they took advice, they wouldn't be lovelorn. You see, advice and lovelorn don't go together. Because advice makes love sound like some sort of cognitive activity, but we know that it isn't. We all know that it's some sort of horrible chemical reaction over which we have absolutely no control. And that's why advice doesn't work.
- Index Magazine interview with David Savage (1997)
- Should novels generally be 600 pages? No, they should not. Half of writing, maybe 3/4 of writing, is editing. This seems to be a thing that has not gotten through to them. It's my impression that you could get rid of half of most of these books. These people are not good enough to be this long, but they're apparently also not good enough to be shorter.
- Ruminator Magazine interview with Susannah McNeely (August/September 2005)
- I doubt there's ever been a true thing said on Fox. Maybe the weather report, maybe not.
- Ruminator Magazine interview with Susannah McNeely (August/September 2005)
- Most of my news, I get from the radio news stations. One of the stations' advertising lines is "Give us 22 minutes, we'll give you the world." In 22 minutes, they just have time for the headlines, so they can only really tell you what happened — which, by the way, is the news. They tell you how many people were killed in Iraq today, but they don't then bring on some Republican senator to explain to you how that's good. Or, on the contrary, they don't bring in a bunch of Democrats to tell you why it's bad. They just tell you what happened. That's the news. I am capable of analyzing my own news. What makes these people qualified to analyze my news for me? No matter what side they're on, I never agree with them.
- Ruminator Magazine interview with Susannah McNeely (August/September 2005)
- Take away a man's actual sense of manhood — which is conventionally based on the ability to work, to earn money, to be self-sufficient, to provide for children — and you've got to give them something else. And they did.
This hideous religion that's all over the country — these huge church-malls — that's what substitutes for these lost towns. But that's not a town. That's a cult. A town is diverse, in a real way, not in this fake way we have now. A community is a butcher and a doctor, a minister, a town troublemaker. A "community" is not a bunch of people united by some grievance. That's just self-righteousness — incredibly dangerous and antidemocratic. People have become so rigid; their opinions seem to them like themselves. When that happens (and it has happened) people can't change their minds. If you are identified by your opinions — if that is the very basis of yourself — how can you change your mind?
- Ruminator Magazine interview with Susannah McNeely (August/September 2005)
- The terrible state of public education has paid huge dividends in ignorance. Huge. We now have a country that can be told blatant lies — easily checkable, blatant lies — and I'm not talking about the covert workings of the CIA. When we have a terrorist attack, on September 11, 2001 with 19 men — 15 of them are Saudis — and five minutes later the whole country thinks they're from Iraq — how can you have faith in the public? This is an easily checkable fact. The whole country is like the O.J. Simpson jurors.
- Ruminator Magazine interview with Susannah McNeely (August/September 2005)
Metropolitan Life (1974)
E.P. Dutton, 1978, ISBN 0-525-15562-7
- All God's children are not beautiful. Most of God's children are, in fact, barely presentable. The most common error made in matters of appearance is the belief that one should disdain the superficial and let the true beauty of one's soul shine through. If there are places on your body where this is a possibility, you are not attractive — you are leaking.
- "Manners" (p. 6)
- Rome is a very loony city in every respect. One needs but spend an hour or two there to realize that Fellini makes documentaries.
- "A World View" (p. 64)
- Any child who cannot do long division by himself does not deserve to smoke.
- "Digital Clocks and Pocket Calculators: Spoilers of Youth" (p. 84)
- I love sleep because it is both pleasant and safe to use. Pleasant because one is in the best possible company and safe because sleep is the consummate protection against the unseemliness that is the invariable consequence of being awake. What you don't know won't hurt you. Sleep is death without the responsibility.
- "Why I Love Sleep" (p. 91)
- Life is something to do when you can't get to sleep.
- "Mars: Living in a Small Way" (p. 101)
- Bread that must be sliced with an ax is bread that is too nourishing.
- "Food for Thought and Vice Versa" (p. 109)
- Women who insist on having the same options as men would do well to consider the option of being the strong, silent type.
- "Letters" (p. 143)
- Having been unpopular in high school is not just cause for book publication.
- "Letters" (p. 143)
- If your sexual fantasies were truly of interest to others, they would no longer be fantasies.
- "Letters" (p. 143)
Social Studies (1981)
- Original thought is like original sin: both happened before you were born to people you could not have possibly met.
- "People"
- The conversational overachiever is someone whose grasp exceeds his reach. This is possible but not attractive.
- "People"
- The opposite of talking isn't listening. The opposite of talking is waiting.
- "People"
- Do not elicit your child's political opinions. He doesn't know any more than you do.
- "Parental Guidance"
- Children do not really need money. After all, they don't have to pay rent or send mailgrams.
- "Parental Guidance"
- Ask your child what he wants for dinner only if he's buying.
- "Parental Guidance"
- Educational television should be absolutely forbidden. It can only lead to unreasonable expectations and eventual disappointment when your child discovers that the letters of the alphabet do not leap up out of books and dance around the room with royal-blue chickens.
- "Parental Guidance"
- No animal should ever jump up on the dining room furniture unless absolutely certain that he can hold his own in the conversation.
- "Pointers for Pets"
- Remember that as a teenager you are in the last stage of your life when you will be happy to hear the phone is for you.
- "Tips for Teens"
- Stand firm in your refusal to remain conscious during algebra. In real life, I assure you, there is no such thing as algebra.
- "Tips for Teens"
- I understand, of course, that many people find smoking objectionable. That is their right. I would, I assure you, be the very last to criticize the annoyed. I myself find many-- even most-- things objectionable. Being offended is the natural consequence of leaving one's home. I do not like aftershave lotion, adults who roller-skate, children who speak French, or anyone who is unduly tan. I do not, however, go around enacting legislation and putting up signs. In private I avoid such people; in public they have the run of the place. I stay at home as much as possible, and so should they. When it is necessary, however, to go out of the house, they must be prepared, as I am, to deal with the unpleasant personal habits of others. That is what "public" means.
- "When Smoke Gets in Your Eyes...Shut Them"


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Wednesday, September 23, 2015
The Most Essential Spiritual Question - Matt Kahn/TrueDivineNature.com
We'd love to stay in touch with you! Please sign up for our free newsletter at: http://www.TrueDivineNature.com (and receive a free Energy Activation from Matt) and join us for an upcoming Soul Gathering, retreat, or Angel Academy:
Thank you to bansuri maestros Steve Gorn and Manose, and tabla maestro Ty Burhoe for their beautiful music. This is excerpted from the "Illumination" CD available at http://www.SteveGorn.com
Matt Kahn is a spiritual teacher, mystic, and highly-attuned empath who, along with meditation guide and yoga teacher and sound healer, Julie Dittmar, travel the world inviting seekers of all faiths to discover their true divine nature.
Matt's spontaneous awakening arose out of an out-of-body experience at the age of 8, and his direct experiences with ascended masters and archangels throughout his life. Many spiritual seekers have experienced amazing, unexplainable healings, and have awakened to their true nature through his profound and loving teachings and his transmission of sacred heart wisdom.
Matt and Julie offer their clear intuitive guidance and loving presence to remove all perceptions of obstacles in your life, and to energetically support you through every aspect of the spiritual journey and experience of awakening.
Whether you directly receive this healing transmission at their Soul Gatherings, or at an upcoming retreat, Matt and Julie joyfully serve the evolution of your soul's wisdom with grace, love, and compassion.
These offerings act as an invitation to directly experience the joy of easing the mind and opening the doorway of your heart - where you will discover an endless depth of effortless freedom, and realize in yourself a love that has no end.
For more information about these teachings, Soul Gatherings, Angel Academies, upcoming retreats, and to sign up for ourTrue Divine Nature free newsletter, please visit: http://www.TrueDivineNature.com
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1 comment:
Pretty good post. I just came across your site and wanted to say that I've really enjoyed reading your posts. In any case I'll be subscribing to your feed and I hope you will keep a good work!Cheer!Spiritual Healer in india|Pranic Healing in BangaloreReplyDelete
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Weather Blog: Cold here for an extended stay
Thank you for stopping by the Weather Watch 12 blog! Howling winds and wind-whipped snow Friday morning gave us a quick reminder that winter has a firm hold on our area. In today's blog we discuss the strong winds, and look ahead to another extended cold snap.
Let's start with the gusty winds that gave many a restless nights sleep, knocked power out for hundreds, and sent temperatures tumbling. Peak wind gusts from Thursday evening into Friday are shown below. The top gust as of this writing in Milwaukee is 51mph!
The intense area of low pressure responsible for the wind, rain, and snow lifts north toward Hudson bay tonight. Expect winds to drop back to 15-25mph, and dry weather to return.
For the first time since the weekend of November 30-December 1 much if not all of southeastern Wisconsin should see a dry weekend! The WPC surface forecast map below is valid at 6pm Saturday. A couple areas of snow will dot the map, one over eastern areas of the Midwest and another over the central Plains.
While southern Wisconsin stays dry, temperatures will remain below average.
The average high temperature in our area is now into the middle 30s. High temperatures Saturday should sneak into the upper 20s in Milwaukee, with teens in central and northern Wisconsin. The GFS forecast temperature map below is valid at 3pm Saturday.
Even colder weather will enter the forecast by Sunday and Monday. The coldest punch of air looks to arrive by the middle or end of next week. The GFS 850mb temperature forecast below is valid next Wednesday. This shows a large chunk of arctic air descending on the Midwest and Great Lakes. This may result in high temperatures in the single digits or teens, or 15-30 degrees below average!
The arctic air looks like it would mean March coming in like a lion. Don't put away your winter coats just yet, there's still lots of winter ahead.
For the latest weather information watch WISN 12 News, and for updates throughout the day follow me on Twitter @jnelsonweather
Have a great day!
Jeremy Nelson


text: Basket Tree Skirt $14.50 Style No. 25633488 Qty: Size: * One Size One Size Sorry, this item is currently unavailable Pick up In-Store » Add to Favorites » Share on Facebook Pin on Pinterest Email a Friend » Details Reviews Complete your tree with this distinctive basket skirt, hand-woven from natural fibers for a folk-inspired alternative to traditional fabric skirts. - A terrain exclusive - Handmade - Natural materials - Imported 10"H, 20" diameter at top, 24" at base


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Style Standoff: Kate Middleton Vs. Cressida Bonas. Whose Side Are You On?
To determine how she'll measure up, style-wise, to her (potential) sister-in-law, we're analyzing how the two wear the same trends —body-con, plaid, monochrome, and more—in very different ways. Decide whose fashion you prefer and shop their looks, here.
Of course, the obvious joke here is that Middleton doesn't do body-con. This slinky purple dress by her favorite label, Issa, is perhaps the most form-fitting thing we've seen her in. (And trust us, we've logged in plenty of research hours).
Issa London Silk Wrap Dress ($901) in Petrol
Photo:Tony Clark / Splash News
The 24-year-old Bonas earns major style points for this sexy-but-chic long-sleeved dress, which she paired with strappy black sandals and a minimalist shoulder bag. We approve one thousand percent.
Topshop Diamond Quilt Body-con Dress ($70) in White
Photo:Indigo/Getty Images
We don't see Middleton in denim very often, and when she does wear it, she tends to pick dressier pieces like this white Zara jean skirt. Here, she looks like a quintessential Sloane Ranger (London's version of a preppy) with an eggplant-hue cable knit sweater and suede knee boots.
A.P.C. Wool Cashmere Crewneck Sweater ($350) in Marine
Photo:Danny Martindale/WireImage
Bonas stays on trend without looking like she tried too hard in baggy overalls, round sunglasses, and old-school sneakers. And we give her kudos for her attempt to single-handedly bring back the scrunchie.
ASOS Denim Overalls ($80) in Mid Stone Wash
Photo:Chris Jackson/Getty Images
Although monochrome can often come across as edgy, Middleton looks anything but in this dainty lace Zara frock and fitted jacket, which she accessorized with high-but-not-too-high heels and the perfect blowout.
Emporio Armani Suede Pump with V-Cut ($395) in Black
Photo:REX USA/Rex Features/Rex
Bonas could easily be mistaken for her catwalker doppelgänger, Cara Delevingne, in this tough lux ensemble consisting of a leather moto jacket, scuffed up ankle boots, studded shortie shorts, and a black knit cap.
Yosi Samra Two Tone Zip Booties ($189) in Black
Photo:Indigo/Getty Images
Middleton's looks every bit the lady in a fit-and-flair Moloh tartan coat, opaque tights, and understated boots.
Betsey Johnson Plaid and Solid Wool Blend Peplum Coat ($240) in Black
Photo:Splash News and Pictures
Trailed by a press-shy Harry, Bonas' dons a sporty plaid jacket. The rest of her ensemble — skinny jeans, combat boots— speaks to a tomboy vibe that's only slightly offset by a navy blouse and statement necklace.
Equipment Ghost Plaid Abbot Bomber ($468) in Black
Photo:Arthur Edwards - WPA/Getty Images
Middleton looks wow-worthy in this blush-hued Jenny Packham dress that's truly fit for a princess. It's glamorous without being glitzy and flatters her slender frame.
Biyan Isobel Embellished Tulle and Satin Gown ($875) in Gray
Photo:Mark Cuthbert/UK Press via Getty Images)
Bonas' blue velvet jacket and floral headwear speaks to a playful boho vibe that's in keeping with her supposedly fun and laid-back personality.
Dagmar Magdalena Marbled Draped Dress ($358) in Cream


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Would like to sell my MTS2000 UHF 403-470 48 channel top display. Radio functions without any problems and has a basic conventional flashcode. I used this radio regularly at a former job, but now I do not have a need for this radio. I would really like to move this, so feel free to make me offers. Radio will come with an OEM battery, antenna, and an Uncle Mike's nylon swivel holster.
Model # H01RDD9PW1BN
Flashcode: 001008-000000-0


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An isolation door was a special reinforced door designed to separate a hazardous area from the rest of a starship or space station. Isolation doors were often employed in main engineering, specifically to seal off the warp core and dangerous antimatter reactants in the event of a warp core breach or loss of antimatter containment.
In 2285, an isolation door automatically activated in engineering aboard the original USS Enterprise following an attack by the USS Reliant. (Star Trek II: The Wrath of Khan)
While the USS Excelsior was under attack by General Chang's Klingon Bird-of-Prey, the isolation door in engineering rolled down. (Star Trek VI: The Undiscovered Country)
Main engineering aboard the Galaxy-class USS Enterprise-D was equipped with at least two isolation doors. The outer isolation door served to separate the warp core and engineer's office from the rest of engineering, the inner door only separated the warp core from the rest of engineering, in an emergency, the engineer's office would still be accessible.
In 2366, the outer door was brought down after a Borg attack caused a hull breach in engineering. (TNG: "The Best of Both Worlds")
The inner door was closed after a faulty dilithium chamber hatch ruptured causing an explosion in the dilithium chamber in late 2367. (TNG: "The Drumhead").
The outer door was used again, sometime between 2366 and 2368, during an accident in engineering which claimed the life of Ensign Keller. (TNG: "Violations")
The outer door also came down when the Enterprise hit a quantum filament in early 2368. It was opened by Commander Riker and Data, whose head had been detached for that purpose. (TNG: "Disaster")
In mid-2369, Captain Jean-Luc Picard sabotaged the warp core in order to escape a group of terrorists who used the evacuation of the Enterprise for routine maintenance as an opportunity to steal highly valuable, and highly dangerous, trilithium resin from the core. Picard triggered a coolant leak which caused the outer door to close automatically. (TNG: "Starship Mine")
Isolation doors were also used in the nacelle tube control rooms aboard Galaxy-class starships. The isolation doors could be opened with the protection of a one-way force field. The doors, however, could only remain open for ninety seconds in order prevent force field degradation and the release of drive plasma. (TNG: "Eye of the Beholder")
In an alternate timeline created when the USS Enterprise-C disappeared from the Battle of Narendra III, the isolation door was used in a vain attempt to contain a coolant leak during a Klingon assault. (TNG: "Yesterday's Enterprise")
In 2371, the door was used in a last-ditch effort to contain the warp core breach which eventually destroyed the stardrive section. (Star Trek Generations)
The isolation door on the Defiant-class USS Defiant was used to seal the engine room when the protective force fields around the ship's warp core were disabled in 2371. (DS9: "The Adversary")
The isolation door on the Sovereign-class USS Enterprise-E was seen when two Son'a battle cruisers fired a subspace weapon at the ship. (Star Trek: Insurrection)
Some starships, like the Intrepid-class lacked isolation doors, as their engineering sections were extremely open and were separate from the rest of the ship with no open corridors leading to the area. (VOY: "Day of Honor", "Waking Moments")
In Star Trek: Elite Force II, the isolation door can be seen closing as the player character approaches the engineering section during the Idryll attack.


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About This Hairstyle: Kherington Payne, from So you think you can Dance Season 4, with a short blonde, wedge hairstyle.
Ask your stylist for this wedge cut, with short short layers in the back, and choppy chunky layers on the front in the ends. You can also ask for textured layers on top, and this will give your crown some lift and volume that you can either sleek straight, or muss up with some product for this funky tousled look.
If you are considering the short look, ensure your stylist spends a healthy amount of time in the layering and texturizing, and you won't have to worry about spending too much time with it after that, you'll look great every day almost as is.
Great hair means a great deal of work and usually that work consists of damaging chemicals and heat usage. There are many great...
This fall the fashion trend is totally turn of the century, with masculine overtones and tweeds.
But that's not all, London...
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