text:
Opinion: MH17: Sanctions on Russia Sufficient?
Business World Columnist Holman Jenkins Jr. on how the downed Malaysian Airlines plane will effect Russian sanctions. Photo: Getty Images
This transcript has been automatically generated and may not be 100% accurate.
... the ... market implications of the Downing of Malaysia Airlines flight seventy know bringing in ... business World columnist Holman Jenkins Junior up home in ... UiTM has anything changed immediately after the president's comments this morning ... no the changes immediately ... the market has been surprises and surprisingly ... muted in its response ... to be in ExxonMobil Ltd under pressure because ... as the rationale is that his campaign if they do ... the the the old companies they all met mother lode of the ones who are ... so low technology and management still the key to Russia's oil flowing and will increase ... Russia's oil output in the future ... can you can integrate that how or why it is to ... wander Putin's regime him he has been unbelievably lucky since he took power in nineteen ninety nine benefited from a ... literally tenfold increase in the price of oil that's the whole basis of his regime and he needs Western technology he has gone offline ... he also needs the oligarchs I know that's as some of the U S sanctions have targeted ... by the CEO Ron snap ... could we see more of that kind of targeting ... by the U S and possibly Europe targeting specific oligarchs ... yet this minute has so far is the message to ... whom we know who who won the really needy in Russia and we have ways to reach out and and it hurt my ... ego is that you ... respect and trust that this is the giant Russian I'll be that produces so much of Vladimir Putin's revenue ... is also his most important factor the guy really has me is that ... if ... push comes to shove in Russian and into ... the missionaries are probably more precarious than most Westerners proceed ... so yeah it's important to focus on a study two questions are ... how ... powerful is their influence over ... who knew the question is how much is true ... here are a revolt from his other people ... mass protests ... that the economy really fares to turn so which is the to do ... we don't know the bank is can you ... do that that's the approach so far ... this year an investor you're looking in all sorts of risk area you're looking at market risk you're looking in interest rate risk of what the Fed ECB might do ... you're looking at all of this political risk omen ... II your raising questions about couldn't ... find his ability to effectively to stay in office ... you know how to price that is that investors may be very difficult isn't it ... he now ask yourself why you're there yet Eugene change feel the goal of the Obama sanctions ... the Europeans are by far not ... on board Noah ... does he told the German news magazine recently posted a story that basically as ... his Germany a nation of Russia on this for long ... term business people and the old East German establishment ... or more favorable to Russian into the US in this ... present situation ... but you know ... if they turn on to ... something like this to shoot down at ... undermines their goods the season for improved ... his ... condition in Russia is not as certain as the money ... a surprise that we don't see more volatility in the market ... given everything that's going on in the world ... absolutely no rat Russia or the fact that we had the war in Europe that the fact that the former cold War antagonists loggerheads over Ukraine in the market has been surprisingly yes ... I'm concerned about this not just the market the stock market and ... made it into something we know maybe this is all this to ... the store ... but ... the term Allah ... Archer before it didn't fall before we


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Installing and Configuring Apache Hadoop for Windows
As has been mentioned in previous posts, I've been spending a lot of time recently working with "Big Data" technologies and have been working more recently with Apache Hadoop and associated distributed computing and analytics mechanisms.
What Exactly Is Hadoop?
If you haven't been exposed to it, Apache Hadoop is an open-source framework that enables distributed processing of very large scale data sets. In a nutshell, Hadoop is comprised of a distributed filesystem, and a framework that allows you to execute distributed MapReduce jobs.
Hadoop has been developed for various flavors of Linux, but is created in such a manner that it can actually run on Windows as long as you have a shell that can support running Linux commands and scripts. While I don't think anyone would argue that you'd want to do this for a large-scale production environment, running Hadoop on Windows allows folks like me who are very comfortable with installing, using and maintaining Windows servers to also work with exciting technologies such as Hadoop.
The purpose of this post is to demonstrate how you can install and configure a Hadoop cluster using Windows Server 2008 R2. In future posts I'll demonstrate using Hadoop and the Hadoop Filesystem (HDFS) to perform large-scale analytics on unstructured data (which is what it excels at!)
Preparing to Install Hadoop
The first thing you'll need to do in order to install Hadoop is to prepare a "virgin" Windows Server. While I suppose it's not really necessary, from my perspective the fewer things that are installed on the server the better. In my case, I'm using Windows Server 2008 R2 with SP1 installed and nothing else. No roles are enabled and no extra software has been installed.
Once you have a server ready (multiple servers if you want to install an actual Hadoop cluster) you'll want to install Cygwin. If you aren't familiar, Cygwin is basically a Linux bash shell for Windows. Cygwin is open source and is available as a free download from: http://cygwin.com/install.html Keep in mind that this is just a web installer. To support Hadoop, we will need to ensure that we install the openssh package and it's associated pre-requisites. In order to do this, start the setup.exe program, select c:\cygwin as the root folder, and then click next. When you get to the screen that asks you to select a package, search for openssl and then click the "skip" (Not exactly intuitive, but it works) text to enable the checkbox for install as shown below:
Once you have selected the openssh library, click next and then answer "Yes" when asked if you want to install the package pre-requisites. Click next and then finish the wizard for install. This will take some time, so be patient.
Once the install is complete, you'll want to start the Cygwin terminal as administrator (right-click on the icon and select "run as administrator") This will then setup your shell environment as follows:
Once Cygwin is installed and running properly, you'll need to configure the ssh components in order for the hadoop scripts to execute properly.
Configuring Openssh
The first step in configuring the ssh server is to run the configuration wizard. Do this by executing ssh-host-config from the cygwin terminal window, which will start the wizard. Answer the questions as follows:
(No to Privilege separation, Yes to install as a service, and CYGWIN as the value)
(yes to different name, and sshd for the name, yes to new privileged user, and a password you can remember)
Once the configuration is complete, open the Services control panel (start/administrative tools/services) and right-click on the Cygwin sshd Service and select start. It should start.
If the service doesn't start, the most likely cause is that the ssh user was not created properly. You can manually create the user and then add it to the service startup and it should work just fine.
Once the service is started, you can test it by entering the following command in the Cygwin terminal:
ssh localhost
Answer "yes" when prompted about the fingerprint, and you should be ready to go.
The next step in configuring ssh for use with Hadoop is to configure the authentication mechanisms (otherwise you'll be typing your password a lot when running Hadoop commands).
Since the Hadoop processes are all invoked via shell scripts and make use of ssh for all operations on the machine (including local operations), you'll want to generate key-based authentication that can be used so that ssh doesn't require the use of a password every time it's invoked. In order to do this, execute the following command in the Cygwin terminal:
ssh-keygen –t dsa –P '' –f ~/.ssh/id_dsa
Once you have the key generated and saved, we'll need to copy it with the following command:
cat ~/.ssh/id_dsa.pub >> ~/.ssh/authorized_keys
This will take the key you just generated and save it to the list of authorized keys for ssh.
Now that ssh is properly configured, you can move on to installing and configuring Hadoop.
Downloading and installing Hadoop
Apache Hadoop is available for download from one of many mirror sites linked from the following page: http://www.apache.org/dyn/closer.cgi/hadoop/common/
Basically just choose one of the sites, and it should bring you to a page that looks similar to the following figure. Note that I am going to use version 1.0.0 which as of this writing is the latest, but the release train for hadoop sometimes moves pretty fast, so there will likely be more releases available very soon.
Click on the version you want to install (again, I am going to be using 1.0.0 for this post) and then download the appropriate file. In my case, that will be hadoop-1.0.0-bin.tar.gz as shown in the following figure:
Once you have the file downloaded, you'll want to use a program such as Winrar which can understand the .tar.gz file format.
The actual install process is very simple. You simply open the downloaded file in Winrar (or other program that can understand the format) and extract all files to c:\cygwin\usr\local as shown below:
Once you are done, you'll want to rename the c:\cygwin\usr\local\hadoop-1.0.0 folder to hadoop. (This just makes things easier as you'll see once we start configuring and testing hadoop)
You will also need the latest version of the Java SDK installed, which can be downloaded from http://www.java.com (make sure you download and install the SDK and not the runtime, you'll need the server JVM) . To make things easier, you can change the target folder for the java install to c:\java (although this is not a requirement – I find it easier to use than the default path, as you'll have to escape all of the spaces and parens when adding this folder to the configuration files)
Configuring Hadoop
For the purposes of this post, I'm just going to configure a single node Hadoop cluster. This may seem counter-intuitive, but the point here is that we get a single node up and running properly and then we can add additional nodes later.
One of the key configuration needs for Hadoop is the location where it can find the Java Runtime. Note that the configuration files we're going to work with are Unix/Linux files and thus don't look very good (or work very well) when you use a standard Windows text editor like Notepad. To keep things simple, use a text editor that supports Unix formats such as MetaPad. Assuming that you extracted the Hadoop files as described above and renamed the root folder to Hadoop, open the C:\cygwin\usr\local\hadoop\etc\hadoop\hadoop-env.sh file. Locate the line that contains JAVA_HOME, remove the # in front of it, and replace the folder with the location you installed the Java sdk (in my example, C:\java\jre. (Note that this is a Unix file, so special characters must be escaped with a "\", so in my case the path is c:\\java\\jre).
This is really all that is required to change in this file, but if you want to know more about the contents you can check out the Hadoop documentation here: http://hadoop.apache.org/common/docs/r0.20.2/quickstart.html (Note that this guide is based on the 0.20.2 release and *not* the 1.0.0 release I detailing here. The docs haven't quite caught up with the release at the time of this posting)
Once you save and close that file, you can verify that Hadoop is properly running by executing the following command inside of Cygwin. (Make sure you change to the /usr/local/hadoop directory first)
bin/hadoop version
You should see a Cygwin warning about MSDOS file paths, and then a version of Hadoop and Subversion located as shown in the figure above. If you do not see a similar output, you likely do not have the path to your Java home set correctly. If you installed Java in the default path, remember that all spaces, slashes and parens must be escaped first. The default path would look like: C:\\Program\ Files\ \(x86\)\\Javaxxxx (you get the idea and probably understand now why I said it would be better to put it in a simple folder)
Once you have the basic Hadoop configuration working, the next step is to configure the site environment settings. This is done via the C:\cygwin\usr\local\hadoop\etc\hadoop\hdfs-site.xml file. Again open this file with MetaPad or a similar editor, and add the following configuration items to the file. Of course replace "hadoop2" with your host name as appropriate:
<?xml version="1.0" encoding="utf-8"?>
<?xml-stylesheet type="text/xsl" href="configuration.xsl"?>
<!-- Put site-specific property overrides in this file. -->
This basically configures the local host (in my case it's named hadoop2) filesystem and job tracker, and sets the dfs replication to 2 blocks. You can read about this file and it's values here: http://wiki.apache.org/hadoop/HowToConfigure (again remember that the docs are outdated for my particular installation, but they still work)
We will also need to configure the mapred-site.xml file to specify the configuration for the mapreduce service:
<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="configuration.xsl"?>
<!-- Put site-specific property overrides in this file. -->
This basically configures the mapreduce job tracker to use port 8021 on the local host. There is a LOT more to both of these configuration files, I'm only presenting the basics to get things up and running here.
Now that we have the basic environment setup, we need to format the HDFS filesystem that Hadoop will use. In the configuration file above, I did not specify a location for the DFS files. This means that they will be stored in /tmp. This is OK for our testing and for a small cluster, but for production systems you'll want to make sure that you specify the location by using the dfs.name.dir and dfs.data.dir configuration items (which you can read about in the link I provided above).
To format the filesystem, enter the following command in cygwin:
bin\hadoop namenode –format
If you have properly configured the hdfs-site xml file, you should see output that is similar to the above. Note in my case that the default folder location is /tmp/hadoop-tmalone/dfs/name. Remember this directory name as you will need it later.
Now that we have the configuration in place and the filesystem formatted, we can start the Hadoop subsystems. The first thing we'll want to do is start the DFS subsystem. Do this with the following command in the Cygwin terminal:
This should take a few moments, and you should see output as shown in the figure above. Note that the logs are stored in /usr/local/hadoop/logs. You can verify that DFS is running by examining the namenode log:
You can also verify that the DFS service is running by checking the monitor (assuming you used the ports as I described them in the hdfs-site xml configuration above). To check the monitor, open a web browser and navigate to the following site:
If the DFS service is properly running, you will see a status screen like the above. If you get an error when attempting to open that page, it is likely that DFS is not running and you will need to check the log file to determine what has gone wrong. Most common problem is a misconfiguration of the site-xml file, so double check that the file is correct.
Once DFS is up and running, you can start the mapreduce process as follows:
You can test that the Mapreduce process is running by checking the monitor. Open a web browser and navigate to:
Now we have success! We've installed and configured Hadoop, formatted the DFS filesystem, and started the basic processes necessary to use the power of Hadoop for processing!
Testing the installation
Each Hadoop distribution comes with a set of samples that can be used to very that the system is functional. The samples are stored in Java "jar" files and are located in the hadoop/share/hadoop directory. One simplistic test would be to copy some text files into DFS and then use the sample mapreduce job to enumerate them. First though, you will likely want to setup an alias to make entering the commands a little easier. In my case, I will alias the hadoop dfs command to simply "hdfs". Do accomplish this, type the following command in the Cygwin terminal window:
alias hdfs="bin/hadoop dfs"
For the first part of our test, we will copy the configuration files from the hadoop directory into DFS. In order to do this, we will use the dfs –put command (for more information on the put command, see the docs here: http://hadoop.apache.org/common/docs/r0.20.0/hdfs_shell.html (again remember that the docs are a little behind)
In the Cygwin terminal window (still in the /usr/local/hadoop directory) execute the following command:
hdfs –put etc/hadoop conf
This will load all of the files in the /usr/local/hadoop/etc/hadoop directory into HDFS in the conf folder. Since the conf folder doesn't exist, the –put command will create it. Note that you receive a warning about the platform, but that is OK the files will still copy.
You can verify that the files were copied by using the dfs –ls command as follows:
hdfs –ls conf
Now that we are sure the files are stored in HDFS, we can use one of the examples that is shipped with Hadoop to analyze the text in the files for a certain pattern. The samples are located in the /usr/local/hadoop/share/hadoop folder, and it's easiest to change to that folder and execute the sample there. In the Cygwin terminal, execute the following command:
cd /usr/local/hadoop/share/hadoop
Once we're in the folder, we can run a simple IO test to determine how well our cluster DFS IO will perform. In my case, since I'm running this on a VM with a slow disk, I don't expect much out of the cluster, but it's a very nice way to test to see that DFS is indeed functioning as it should. Execute the following command to test DFS IO:
../../bin/hadoop jar hadoop-test-1.0.0.jar testDFSIO –write –nrFiles 10 –filesize 1000
If you don't see any exceptions in the output, you have successfully configured Hadoop and the DFS cluster is operational.
While it isn't exactly a simple process, you can indeed get Apache Hadoop up and running on a Windows platform. I've taken the path of configuring Hadoop with Cgwin as the shell, but there are those who claim to have installed and configured Hadoop on windows without the use of Cygwin. Either way, I'm just glad it works and folks who don't want to invest in building a Linux environment have the ability to play around with and use Hadoop.

subset: commoncrawl


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text:
Is Warren Buffett really losing his mojo? That\'s the assertion behind a weekend New York Times column by Jeff Sommer keying off a statistical analysis by statistician Salil Mehta that finds Buffett, while having enjoyed a stellar run over the past nearly half-century, isn\'t doing so hot recently.
The study finds that while Buffett has produced an impressive dose of alpha — the ability to outperform the market without adding risk — over several decades, his more recent performance \"isn\'t impressive at all,\" Sommer writes. Read a related blog post by Mehta here.
For four of the past five years, Sommer recounts, citing the analysis, Buffett has underperformed the typical, no-frills S&P 500 stock-index fund. In fact, he\'s done \"so much worse that it\'s unlikely to be a matter of a string of bad luck. Mr. Buffett has begun to behave like an investor with no alpha at all,\" Sommer writes.
Sommer and Mehta both take pains to emphasize how impressive and, perhaps more importantly, how rare Buffett\'s long-term track record has been. Buffett from 1965 through the end of 2013 outperformed the S&P 500, including dividends, by 9.9 percentage points, annualized. According to Mehta, that puts Buffett in a group amounting to less than 1% of the total investor population statistically likely to have been able to beat the market over a period of 45 to 50 years.
At the same time, Sommer notes, the analysis finds that there\'s only a 3% chance that Buffett\'s recent underperformance is the result of bad luck.
Buffett\'s defenders argue that while there are many useful observations in Mehta\'s analysis, it doesn\'t mean Buffett has lost his edge.
Michael Ide at value-investing blog ValueWalk argues that Buffett\'s long-term strategy historically earns less when the market soars and loses less when it falls, leaving it to come out ahead on an annualized basis over nearly 50 years. (A point made by Buffett in his last shareholder letter and acknowledged by Sommer and Mehta).
Eamonn Fingleton, writing at Forbes, argues that Mehta is missing an important point. While the share price of Berkshire Hathaway rose 84% from end-2008 to end-2013 versus a 104% rise by the S&P 500, the more important measure is Berkshire\'s profit performance, which has risen 268% on a per-share basis.
–William Watts
Follow William on Twitter @wlwatts
Follow The Tell @thetellblog
More from MarketWatch
How sector funds can make your portfolio whole
The rise of the iPhone stock trader


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Welcome to the inaugural post of my very first blog. My name is Christine and I am a divorced mother (Divorce Class of 2004) in Austin, Texas, raising an eight-year old daughter. And I have to say, things are going shockingly well. Finally.
It has been a hell of a ride.
I don't like to reflect on the year right before my divorce, much less the year right afterwards. I have never felt or acted less like myself. I remember trying to explain to a girlfriend that I was being such a chicken, terrified of the very things I used to do without effort. Scared to write. To eat at a restaurant by myself. To go to PTA meetings. To speak to clients. To be alone for an entire weekend. And not just any chicken...I felt like a chicken being choked around the neck, while having my feathers plucked out one by one. Naked and exposed and certain that the stifling grip was ironically the only thing keeping me from sliding into a pot of boiling water.
I'm sure a trained therapist would say I was likely suffering from some social anxiety disorder and temporary paranoia brought on by the stress of my marriage ending. But I didn't give my therapist enough couch time to hear all the gory details. And I stopped sharing with friends too. If you've been through a divorce you know how that goes. As wonderful and supportive as they are, our friends can literally only hear so much. And my friends did not like seeing me as the scared little chicken. Not one bit. It just didn't compute. So each day I would either feign mental health or hide out in solitary confinement. I did most of my grocery shopping at 7-11 in those days.
At this time I actually had a kickass executive job at a consulting firm where former Texas Governor Ann Richards was a senior advisor. I had the good fortune to work on a few client projects with her which was a treasure in its own right. But one day, I got a gift I could have never expected.
Her assistant rang my office and said that Ann wanted to see me. Truthfully I was hoping to spend a meeting-free day behind closed doors doing some actual work. Ruffled by this unexpected call I madly grabbed the client folder I assumed she wanted to discuss and scurried down the hall to her office. Bluntly she said, "Rumor has it you're going through a divorce." Rattled, I barely maintained my executive polish a bit longer, politely confirming that 'yes', in fact, I was going through a divorce.
Well she stripped me of that lovely veneer as fast as she could talk. She'd been there and wanted to know exactly how I was doing. How many girlfriends did I have who had been through it. That wasn't many. She gave me a reading list of novels and told me to come back and talk with her about them for fun. Asked if I'd like to go to a movie sometime. What restaurants did I like. Not to worry about any friends that would ditch me. Find better, more interesting friends. Stay busy. She finished as bluntly as she began, "Listen Christine, you are in the fight of your life. Just remember how brave you are. And for heavens sake, don't hang out in your house alone. If you need something to do, call me."
Well I was blown away! Besides being a little bit scared of her directness, I was really very touched. Governor Ann Richards took the time to check in on me. Me? ME?? I mean, just the day before I had been eating Cheetos in bed while on a client conference call. Her tough words were inspiration enough to rise to the challenge. That was it. I was going to be FINE. Enough of being a depressing ninny. I wanted to be the courageous woman Ann Richards thought I could be. I was going to wake up the next day and toss out the Hostess Cupcake wrappers on my nightstand, eat whole grains, fruits and vegetables, host interesting dinner parties and be an all around fabulous divorcée.
Well, of course that didn't happen, at least not the next day. I wallowed for months to come. Quit my job. Got a little more lost before I was found. There were more Hostess Cupcakes. My countless trips around the Whataburger drive-through became like the scene in 'Alice in Wonderland' where the fantasy creatures race round and round an island in circles without a clear start or finish line.
And then a funny thing happened.
I was at my daughter's elementary school last year and another mom was telling me about the divorce she was going through. As if channeling Ann Richards, I went into caretaker action mode. I asked if she had plans for Mothers Day, and with a air of upperclassman confidence and experience I outlined her Mothers Day plans and explained how critical it was for her to be prepared for such a tough day post divorce.
And that's when it hit me. Life goes on. There is a whole a new freshman class of divorced moms coming up the ranks, and my pain is old news. Thank heavens. How liberating. And suddenly I realized I had long since graduated from being a scared little plucked chicken, into a bold, plucky chicken. Life is ok. My daughter cracks me up daily. I love being a homeroom mom. Dating life is no longer treacherous – now it's just hysterical and fun. I am so busy with friends that I relish time alone. And lo and behold here I am writing again.
Governor Richards died last year so we never made it to the movies. They have renamed a bridge in downtown Austin in her honor, and I can't think of a better metaphor for the role she served in my life. She was my bridge. Her advice helped me get to the other side of a really painful era, and I get farther from it each time I pass along her advice to someone else. So for me, the question isn't "Why did the chicken cross the road?" but "Why did the chicken cross the bridge?"
My answer is simple: "Because Governor Ann Richards Kicked My Butt To Get Over It."
Welcome to Chicken Fried Therapy. Be a brave chicken.
Friday, November 2, 2007
One Plucky Chicken
Welcome to the inaugural post of my very first blog. My name is Christine and I am a divorced mother (Divorce Class of 2004) in Austin, Texas, raising an eight-year old daughter. And I have to say, things are going shockingly well. Finally.
Posted by Chick at 10:01 AM
Labels: divorce, governor ann richards, mother, survive divorce
19 comments:
- bhandler said...
Yes, Christine, you are "one plucky chicken" and one hell of a writer. I am thrilled to read you again and look forward to saying "I knew her when"... Thanks for the treat! Betsy
- November 2, 2007 at 12:26 PM
Tine - Thanks for the great read! Betsy is right - you are one hell of a writer, and I can see this blog turning into a book one day. Looking forward to more, my friend. Anne
- November 2, 2007 at 4:15 PM
- Mary said...
It has been one hell of a ride and I am so proud of you! Your wit and insight will surely help women going through divorce (and their friends).
- November 3, 2007 at 8:56 AM
Glad you are back Tine! We need another Vegas trip with the rediscovered you. Miss you tons. Keep on writing! love you lots
- November 5, 2007 at 8:56 AM
- Mark S. said...
This is exactly what I needed to read today! Great work.
I could really use some oral chicken fried therapy....please call soon!!
Much love, Mark
- November 5, 2007 at 11:52 AM
Well, as a divorced daddy (class of 2006), it rings pretty familiar. Great writing Christine. Come back out of your shell and get out to see some music!
- November 5, 2007 at 12:25 PM
- Donna Campbell said...
LOVE IT....felt as though I was reading the intro to a spicy new novel! I always say to call Christine when you need to be entertained and I'm thrilled to know you are just a click away!!! Love you, my friend ~ D.
- November 5, 2007 at 3:29 PM
How fun to meet you this past weekend, try to remember everything we talked about post-post cocktail hour, and then read your blog. Your sense of humor came flooding back to me.......we have to talk! BTW: favorite part - the boiling water bit
Loved it,
- November 8, 2007 at 3:41 PM
- Rick said...
Spot on, Tine. Even talking about your pain you crack me up. Love that after all these years and growing up together we are now in the same town. We definitely need to kick it more.
ditto to what BH said...
- November 12, 2007 at 6:43 AM
- Diana said...
Being newly divorced (a month) I can totally relate to this story! Your description is right on the money!
- December 1, 2007 at 2:17 PM
What a great story and post to kick off your blog with. I look forward to catching up with all your other posts and following you along your journey!
-- BusyDad (busydadblog.com)
- December 1, 2007 at 3:39 PM
- BethGo said...
Wow. I can't wait to hear more.
You and Ann Richards are both an inspiration.
This is the line that sticks with me:
"Not to worry about any friends that would ditch me. Find better, more interesting friends."
I may have to quote you both on that one!
- December 2, 2007 at 10:58 PM
Welcome to blogland....Plain Jane Mom sent me...and now you must be added to my reader....
- December 3, 2007 at 8:24 AM
- Country Mouse said...
This is a hell of a first post. (I've also read all of your other posts to date. They stand up to the expectations this one sets — well done!)
I love your Ann Richards story. What a wonderful thing to do for someone at an awful time in anyone's life.
—Lou of Whatever Works
- December 3, 2007 at 11:04 AM
- canape said...
I found that the friends I lost during my divorce hurt worse than the husband that I lost. Probably because it was so unexpected.
But you are right, there are new, more interesting friends now.
Glad Plain Jane Mom linked you up!
- December 4, 2007 at 8:15 AM
- Andria and Co. said...
I just read your blog from beginning to end, or rather, end to beginning. I too, live in Austin, and am potentially facing a divorce soon. What's great is... I just had a baby 5 weeks ago. So yeah, life is GREAT right now. I've noticed that the few friends that I have confided in, seem to twitter condolences, while acting as if I have the plague. Divorce isn't contagious... is it? All I know is, I am scared. Scared of potentially going at this alone. Finances, parenting, all that jazz.
I always knew Ann Richards was a kick-ass woman, this just solidified it! Great post!!!
- December 16, 2007 at 9:49 PM
- josey said...
hey chica :) i've been making it a point to read a lot of the archives of ppl's blogs i'm into. it's awesome to see where you've come from and what your blog (and life!) are all about. you're an inspiration. and (DUH!) you're superdooper hilarious :D (two of my most important pre-requisites for a bloggin bud. LOL!)
hope your Christmas was so very special and that your new years is SAFE and FUN!!!
- December 28, 2007 at 12:09 PM
- Rod said...
Good stuff!
- September 6, 2009 at 8:59 AM
That's exactly what I needed to hear right now.
Thank You
- March 10, 2012 at 10:45 AM


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ipernity needed a new logo design and created a contest on 99designs.
A winner was selected from 482 designs submitted by 108 freelance designers.
http://www.ipernity.com is a social media on the internet aiming to become people's home for digital life.
ipernity offers the ultimate place to host, organize and share all kind of content (photo, blog, video…) produced by everyone during his whole life.
-- ipernity = IP (internet) + eternity
-- home for digital life
-- social media
Brand values:
-- timelessness
-- simplicity
-- universality
-- sympathy
To learn more, browse http://www.ipernity.com and even, sign up for free ;-)
-- Worldwide: mainly western Europe and US.
-- Mature: aged 25+, both male and female
-- Both family and photographers
We are looking for both ICON + BRANDMARK for Web use (main) and printing.
-- the brandmark MUST WORK ALONE, without its icon
-- ideally, the brandmark graphically separates "iper" from "nity" for a better reading and memorization
-- the brandmark should be written using low case
-- the brandmark must work horizontally, at the top left of ipernity pages, inside a 25 pixels high banner
-- the icon must work inside a 16x16 pixels square
-- the icon must be a piece of the brandmark, or something reminding the brandmark
-- icon and brandmark must work on light / dark / colour background
-- icon and brandmark must be viable in « white on black » and « black on white »
-- vector-based graphics
We recommend you to browse http://www.ipernity.com to see how it should work.
Find out how a design contest works or learn more about our logo design services.


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Pancakes and Booze Art Show
Let's see: all-you-can-eat pancakes, cocktails, art, music ... um, yeah, think we're done here. The popular Los Angeles underground art showcase for emerging artists is coming to Chicago. The Pancakes and Booze Art Show will have a live art battle, body painting, a pancake bar, and audio and visual performances. Why go: Hello? What part of all-you-can-eat pancakes, cocktails, art and music didn't you understand? Reconsider: Wait, pancakes but no bacon and eggs? 8 p.m. Friday at Reggies, 2105 S. State St.; $5 (21+); reggieslive.com
Copyright © 2019, Chicago Tribune


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Everyone stay calm.
That's David Westcott's message to finance and insurance professionals, even though the chairman of the National Automobile Dealers Association admits he is very concerned.
Westcott and many dealership F&I managers worry about how the probes by the Consumer Financial Protection Bureau and the Department of Justice into potential patterns of discrimination in lending could impact car dealerships.
While most dealerships are exempt from the bureau's oversight, it has jurisdiction over buy-here, pay-here dealerships and auto lenders. Any restrictions it places on lenders could impact a dealer's third-party financing model.
The bureau's director, Richard Cordray, has said dealers deserve "fair compensation" for handling finance transactions, but has objected to the potential for discrimination, even if it's accidental, in the setting of the dealer reserve.
Eventually, the bureau's scrutiny could affect how much finance reserve a dealer can earn -- if any.
Still, Westcott isn't ready to hit the panic button.
"We'll keep having communications with the CFPB and talk about the topic and get some transparency from them as well," Westcott says. "In the last two weeks we've had a couple conversations and in the next two weeks we'll have some more meetings with them. They're receptive to that."
Westcott says NADA's discussions with the bureau won't center on the possible smaller finance reserve or how that would impact a dealer's business. Instead, NADA will emphasize how consumers benefit from dealer-assisted financing.
"It offers the consumer an opportunity to negotiate and get better rates," Westcott says. "Are we concerned about the CFPB's notifications to banks? Certainly. But we're most concerned about limiting the access to credit to consumers and their ability to get lower rates."
Westcott says dealers don't need more regulation because the Federal Trade Commission regulates their business, and the FTC has "determined our program is fine."


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Xclusive - Break It Down (She Got A Steamy Message For You Bow Wow) "Age Aint Nuttin But A Number Bow"
M reports "Xclusive aka 90's LIL KIM Break It Down (Bow Wow Response)"
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A while back I was considering the vast array of airguns that are available for purchase today, and it came to me that there was a hole in the marketplace. What was needed, I thought, was a "transitional" gun – one that filled the place between BB guns, like my beloved Daisy Model 25, and the more serious small guns like the HW25L or HW30.
The gun would have to be small, reasonably light, easy to cock with one stroke, affordably priced, and usable by the whole family. It wasn't long thereafter that a package arrived from UmarexUSA with a Ruger Explorer in it, and it seems to be just what I had in mind.
The Ruger Explorer is a "youth" airgun with a spring-piston powerplant. It's only an inch over a yard long; the length of pull is just 12 inches, and it tips the scales at just 4.5 lbs. When I pulled it from the box, my first thought was: "Wow, this is really light and easy to handle."
The most striking feature of the Explorer is the ambidextrous black composite all-weather thumbhole stock that is just loaded with swoopy styling. Starting at the rear, the butt pad is made of a polymer that is softer than the rest of the stock. Moving forward, the buttstock itself is so radically abbreviated as to almost not be there. The checkpiece is ventilated; the pistol grip is nearly vertical, and underneath it you'll find the Ruger logo.
Moving forward, the trigger guard is molded into the stock, and it encloses a metal trigger fashioned from sheet metal. Ahead of that is an indent (where I place the crook of my arm when shooting from a sitting position), following by a contoured had grip on the forestock.
Ahead of that is the barrel, which is clad in polymer and has a molded-in muzzle break that incorporates a mount for the front red fiber optic sight. Moving backwards, you'll find the breech block which mounts an adjustable rear sight with green optical fiber. To the rear of that is the rest of the receiver which has dovetails for mounting a scope, followed by a screw-and-tab gizmo that functions as a recoil stop for a scope. At the very tail end of the receiver is a black polymer receiver cap and a black polymer push-pull safety.
The specs on the Ruger Explorer claim 495 fps, and I got 483 average, launching 7.9 gr Crosman Premier pellets through my Oehler chronograph, which works out to about 4 foot-pound of energy.
To get the Explorer ready to shoot, grab the muzzle break and pull the barrel down and back until it latches. This take about 16 or 17 lbs of effort and open the breech for loading. Stuff a .177 pellet in the aft end of the breech and return the barrel to its original position. Take aim, push the safety off with your thumb, and squeeze the trigger. At about 1 lb 7 oz, the first stage comes out of the trigger. At 4 lbs, 13 oz, the shot goes down range. The report is a muted "doink," and recoil is almost non-existant.
I tried shooting the Explorer with Crosman Premier light pellets at 13 yards from a sitting position using the fiber optics sights and got 1.25" edge to edge groups. So I ran to the workshop, grabbed a 3-12x44mm scope and mounted it on the Explorer. (Now, I know what you're thinking: why in the world would anyone mount a $190 scope on a $60 air rifle? I have three really good reasons: (1) it was already sitting out on my work bench, (2) the mounts were already on it, and (3) it looks really cool.) I went back outside and tried again from a sitting position at 13 yards, but this time using Daystate FT pellets. This time, the five-shot groups shrank to just a hair over .5 inch CTC.
Would the Explorer do better with different pellets from a steadier rest? Maybe. Certainly it's plenty good enough for assassinating a bagful dollar store dinosaurs at 10-20 yards and nailing soup cans at much longer range.
I predict that if you slap a cheap scope on a Ruger Explorer, sight it in, and hand it to any kid who has even the slightest interest in shooting, you'll have them grinning in no time. I found this gun so much fun to shoot that I predict the kid will have a hard time getting the Explorer out of Dad's hands.
Til next time, aim true and shoot straight.
– Jock Elliott


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About DCP2
In April 2006, The Disease Control Priorities Project released the second edition of Disease Control Priorities in Developing Countries (DCP2) that highlights cost-effective interventions based on careful analysis of health systems, the costs of disease burden, treatment, and prevention for a comprehensive range of diseases and conditions. It also provides the results of in-depth research, offers insightful analyses, and proposes context-sensitive policy recommendations to significantly reduce the burden of disease in developing countries and to improve the quality of life for all people.The second edition of this seminal work was written by more than 350 specialists in diverse fields from around the world.
As part of its comprehensive global health examination, DCP2 asked:
- What progress has been made in defining and reducing the global burden of disease?
- How much have countries accomplished in developing and providing efficient, effective, and equitable health care?
- How can they set and achieve priorities in health services?
- Once these countries have identified the priorities, how can they deliver interventions to the targeted population in the most cost-effective manner?
- How can efforts in health and related sectors–such as nutrition, agriculture, water and sanitation, and education–be integrated to improve health?
- DCP2's answers contribute substantially to global initiatives to improve the health of all peoples by providing a multidisciplinary understanding of these fundamental issues and challenges, as well as effective interventions for the range of communicable and noncommunicable diseases and conditions and risk factors.


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AUSTIN, Texas – Erik Murphy had 18 points to lead four Florida players in double figures and the Gators shut down the NCAA's highest-scoring team Friday night, beating Northwestern State 79-47 in the second round of the South Regional.
No. 3 seed Florida turned this one into a rout with a 19-1 run in the second half and held the 14th-seeded Demons (23-9) to their fewest points this season – 34 below their average.
Patric Young had 16 points and nine rebounds for Florida (27-7). Kenny Boynton and Scottie Wilbekin both scored 11.
DeQuan Hicks had 12 points for the Demons, who upset Iowa as the No. 14 seed in their last NCAA tournament seven years ago.
They couldn't repeat that feat against the Gators, who lost in the regional finals each of the past two seasons.
Florida plays Minnesota or UCLA on Sunday.


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In the second film there was the 'tauntaun' on the ice planet Hoth, and as a hairy mammal-like animal with the body plan of a bipedal carnivorous dinosaur that was an intriguing invention. Otherwise, not many in the early stages came across as great exobiological inventions. In fact, quite a few some could not be taken seriously at all: just think of the gigantic snake-like animal living in an asteroid (in a vacuum!), large enough to have the Millennium Falcon fly between its teeth. Or take the 'Sarlacc', a carnivorous monster buried in the sand on Tatooine: all you see of it is a gigantic mouth in a pit in the sand, reminiscent of an antlion but scaled up to a gigantic level. Its very existence implies that there are lots of rather stupid animals ready to stumble into it maws. No-one would take such a creature seriously from a biological point of view, and no-one should; it's not what the films are about.
Still, there is a book about the animals in the Star wars universe, showing someone cared. It is called 'The Wildlife of Star Wars. A Field Guide', by Terryl Whitlatch and Bob Carrau. Terryl Whitlatch has been working as a 'creature designer' for several of the Star Wars films. Typing her name into Google results in so many hits that I do not need to provide many links. Still, here is one with a video interview, and here are two on character design (one and two).
The 'Wildlife' book first came out in 2001. I had somehow missed it completely until recently, when a reprint was issued. I found another book of hers showcasing other work, not related to Star Wars: 'Animals Real and Imagined'.
The Star Wars book seems to have many creatures in it that did not appear in the films as far as I know. I have to be careful here, as the three newest films (I, II and III) did not make much of an impact on me, aimed as they seemed to be at children. I suspect that most of the animals in the book were not in the films at all, which would imply that Ms Whitlatch had more or less free reign in designing them.
The sillier animals such as Giant Space Slugs of over 900 meters long, and the above-mentioned sarlacc occur in the book, should you wish to know more about them. The animals that I assume to be Ms Whitlatch's inventions were much more to my liking. In a way they conform to the general exobiological theme of Star Wars. In it, intelligent beings are almost always humanoid, with two legs, two arms and a sort of alien-looking head that is rather larger than the standard Earth issue human head. The films started when digital creature design did not exist, and alien design followed time-honoured principles, involving actors in rubber suits. Hence the big heads.
Ms Whitlatch's aliens more or less follow such principles. The book deals with life on several planets, but you will not be able to determine their planet of origin by looking at their body plan: an animal could come from one planet as well as from the next. Whereas nearly all intelligent beings are humanoid, animals also share many design principles with Earth animals. Quite a few are 'mammaloid', meaning they look a lot like mammals with odd heads. There are also plenty of aviforms and reptiloids, as well as combinations of designs. It is interesting to compare this design strategy with that of Mr Broadmore's Victorian Venusian life forms discussed recently: these were specifically designed to evoke a sense of displacement, i.e. of 'alienness'. Instead, Ms Whitlatch's life forms might be just around the corner. That makes them more believable, but inevitably less alien.
Regardless of the degree of their 'alienosity', the animals are all superbly well drawn, with an intimate knowledge of animal anatomy and behaviour. The 'Animals Real and imagined' book contains drawings of existing animals in addition to fantasy ones, proving once more that Ms Whitlatch is a very skilled artist. I will go through a few of her drawings, scanned from the two books. As I did not wish to damage the books, I had to crop some drawings a bit, for which I apologise (you could all get the books yourselves...).
These are Motts from the planet Naboo, revealing how mammalian their body plan is. The way the legs fold, the number of joints, the general shape of the head, all these things say 'earth mammal'; 'ungulate' in fact. But look at the ease with which their poses are captured, and the green thingy walking away from the motts is much more 'alien'!
Also from Naboo, these gullipuds are, as the text says, amphibians. They resemble puffer fish or indeed, some Earth amphibian in being able to inflate their bodies. I like the sense of humour in this and other drawings.
The tree-dwelling Shaupaut. This is another mammaloid. Its elongated fingers are apparently used to 'fish' for avians flying by.
These animals are apparently extinct. They are labelled as stalking birds from Alderaan, and are obviously modelled on large African ground living birds, called 'ground hornbills'. These walk in rows over open fields, hoping to disturb smaller animals so they can be caught and eaten. These birds are doing the exact same thing.
The text says that their span is about two meters, which means that they must be very heavy. Their bodies and thick tails look good, but do not appear to be designed to save weight. Light bones? A heavy atmosphere?
This one is not from the Star Wars book, but from the other one. It represents one of the few designs that I do not really like. The reason is that it reminds me too much of the six-legged forms in Avatar that I discussed earlier. Like the Avatar animals, this one does have six limbs, but not as three pairs with their own characteristics, but as one pair of hind legs and two pairs of identical front legs. In fact, their muscle anatomy shows the same problem as Avatar's thanator: the front limbs are, like those of Earth mammals, connected to the axial skeleton almost entirely by muscles. Note that the two sets of muscles seem to run through one another...
I would rather end with something I like better: the Nuna from Naboo, which is a very interesting and humorous drawing. The one on the left is a male, inflating his wattles and hissing to underline his dominance. You can see how well Ms Whitlatch combines animal anatomy with the expression of emotions. The emotions are very readable to us, which is probably not at all would you would expect from alien life forms. Then again, emotions help tell a story, and that is done very well here.


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Hope you are enjoying all the Crafty Individuals inspiration so far this week. Linda is with us today with a beautiful card and some triple embossing techniques to make a stylish seal.
See you tomorrow
Nice work, I am really glad to be 1 of several visitants on this awful site : DReplyDelete
I've been in 2 minds about this set but you have definitely put it on my wish list.ReplyDelete
Love the deep colours of the background and the embossing looks great!ReplyDelete
That embossing looks fantastic !ReplyDelete
I love your pieces! I've resisted all 'national' type stamps but your work has convinced me that I do need some! I like the colours you've used because they are NOT red, white and blue! Not very pc of me! Glad I saw this - pity the stamps are already out of stock at my favourite shop!
We are very grateful for any comment you might leave.
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Hey Tater,
Jim Patton from The Haunted Enthusiasts here. We met you last year at Greg & Christina Allen's place, Fear Fest, in Columbia, MO. Was wondering where all you planned to act this year. We loved getting the chance to meet you and look forward to seeing you again! Take care and have a GREAT season!!!! The Haunted Enthusiasts
HAPPY BIRTHDAY TATER. And wishing you many more.
Wish I could of seen the granny.
Congrats on a wonderful job Granny, I too saw you the other night and you were the best! That's all we talked about the rest of the night and next day. Love ya Granny
It was great meeting Granny last night at Fear Fest!! Hilarious!!
Granny, we will be open the last weekend in September why not come and join us at the farm? Being the first weekend it will crazy but it should be fun.
hey you nut! That was the wrong hearse! We had Haunted Farm Pleasantville on the tail gate. When are you gonna come out and see me? Not like you are far away LOL
Senior Member
Junior Member


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Tuesdays at 1 PM Pacific Time on VoiceAmerica Kids Channel
KIDS FIRST! Coming Attractions is a weekly radio show hosted by the KIDS FIRST! Film Critics - 24 youth, ages 7 to 16 from across the country. These reporters review the latest films and DVDs, interview celebrities and chat about media related events. They attend premieres and press screenings of just about every new film rated PG-13 or younger and bring you the scoop so you can make informed decisions about what you wish to see. At KIDS FIRST! we believe that "Smart Kids Make Smart Consumers."
KIDS FIRST! Film Critics, a program of the 23-year-old Coalition for Quality Children's Media, is the country's most valued source for reviews of children's media. As a national, nonprofit organization, KIDS FIRST! teaches children critical viewing skills and kids as reporters to help you make informed decisions about what films you select for yourself.
Listen to KIDS FIRST! Coming Attractions every Tuesday at 1PM Pacific Time on the Voice America Kids Channel.
KIDS FIRST! Coming Attractions is a weekly radio show hosted by the KIDS FIRST! Film Critics - 24 youth, ages 7 to 16 from across the country. These reporters review the latest films and DVDs, interview celebrities and chat about media related events. They attend premieres and press screenings of just about every new film rated PG-13 or younger and bring you the scoop so you can make informed decisions about what you wish to see. At KIDS FIRST! we believe that "Smart Kids Make Smart Consumers."
KIDS FIRST! Film Critics, a program of the 23-year-old Coalition for Quality Children's Media, is the country's most valued source for reviews of children's media. As a national, nonprofit organization, KIDS FIRST! teaches children critical viewing skills and kids as reporters to help you make informed decisions about what films you select for yourself.
Listen to KIDS FIRST! Coming Attractions every Tuesday at 1PM Pacific Time on the Voice America Kids Channel.
Podcast Information
About the Host
Eleven-year-old Samantha Alexander lives in New York City with her family. Sammie, as her friends call her, has two older sisters (Lisa, 29 and Maylene, 25). Samantha says that her family enjoys gathering together for dinners, playing board games and going to movies. When she is alone or with friends, she likes to play the WII or go to the park and, of course, face-time on the phone. Like many kids, her favorite foods are pizza, mac 'n cheese and chicken nuggets. The Boy in the Striped Pajamas is a favorite movie of hers because it was a true story that she finds quite interesting. When she grows up, she would like to become a journalist or police officer. She is most proud of the fact that she was asked to write a speech for the opening of her new school. At the ribbon cutting ceremony, Fox 5 and NY 1 interviewed her and all her friends and family were able to see her on TV that evening. As a KIDS FIRST! Film Critic, she looks forward to getting early views of new movies and sharing her opinions with others. Twelve-year-old Anthony Aranda comes from San Diego, CA where he lives with his parents and two siblings, ages 9 and 7. He has a dog named Patches and, when he's not going to movies, likes to visit Chuck E Cheese and play baseball. He aspires to be a professional baseball player when he grows up. His favorite movies are Ironman 2 and Nanny McPhee. In his free time, Anthony likes to read books and play games such as Four Square. Diary of a Wimpy Kid is his favorite book and Selena Gomez is his favorite actor. Anthony's most proud of getting all As in school and getting into the accelerated classes. The thing he enjoys most about his job as a KIDS FIRST! Film Critic: "Interviewing celebrities on the Red Carpet!" He has interviewed Pixar / Disney's Chief Creative Officer, John Lasseter, American Idol finalists, Danny Gokey and Brooke White, and appeared on the red carpet at the Newport Beach Film Festival and at MCAS Miramar. Jailene Aries, age 14, lives in Burbank, CA with her parents and three brothers who are 7, 22 and 24 years old. Her nickname is Welches. She enjoys going to the mall with her mom and talking about life. "We spend a lot of time in the car together going to auditions, guitar lessons, gymnastics and other activities." She also enjoys watching films on DVD at home with a bowl of popcorn or ice cream. She loves going out to dinner at a nice restaurant. Her favorite food is spaghetti and meatballs. When she's alone, Jailene might be found playing the guitar, reading books on her Kindle, listening to music or watching her favorite TV shows. Her favorite thing to do with friends is to go to the movies. Jailene's favorite film is Monte Carlo because her favorite actress, Selena Gomez is in it. She also enjoys the love story and the humor. Selena Gomez wins her vote for favorite actress because of her talent and the great work she has done since she was very young. "I also admire her dedication to her career. She is a great actress and an inspiration for other young Latina girls who want to pursue an acting career." The thing that Jailene is most proud of is how she and her family moved from Maryland to California in order for her to pursue a career as an actress. Jailene's favorite film critic is KIDS FIRST! Film Critic Cheyenne Nguyen, one of her best friends, because "she is very energetic and brings so much personality to her reviews." As a KIDS FIRST! Film Critic, Jailene looks forward to watching amazing films and informing people about them. "I want to educate parents and let them know if the films are appropriate, funny, sad or serious. I want to have fun and go to red carpet events and develop interview techniques that are useful skills no matter what I end up doing in my life." Fourteen-year-old Brianna Beaton lives in Clermont, FL with her parents. She has a 23-year-old sister who lives in Philadelphia, Pennsylvania. Her favorite things to do with her parents are play board games, watch TV, and cook. Brianna also likes to read and write stories. You can find Brianna playing tag, swimming and just goofing off with her friends who call her BB. Brianna's favorite movie is I am Sam. Brianna looks up to actress Drew Barrymore because she started acting young and is the kind of person who doesn't care what anyone says about her. Brianna wants to be a successful actress and a restaurant owner when she grows up. She also wants to write a fictional novel. She is most proud that she has been performing in theatre plays and won Best Actress, Most Dramatic, and Most Reliable awards in her theatre school. Brianna enjoys sharing and expressing her feelings about films through video and written reviews. KIDS FIRST! gives her many opportunities to write. Valdi Belizaire, age 12, lives in Los Angeles, CA and has two sisters, Stacy (12) and Bella (5). During family time, she loves to play games, go to the mall and visit the park. When with her friends, Val, as they call her, enjoys playing games, doing projects and says, "We read each other's stories." Valdi's favorite film is Brave because it shows a lot of bravery and to fight for what you believe in. Her favorite actress is Anne Hathaway since she, "has a lot of passion in the movies that she does." One of Valdi's greatest accomplishments is that she read 40 books in just a few months. Twenty of the books were in English and twenty were in French. When Valdi grows up she wants to be a actress or a lawyer. As a KIDS FIRST! Film Critic she looks forward to having people watch me and be interested in what I have to say. Stacy Belizaire, age 11, lives in Los Angeles, CA and has two sisters, Valdi and Bella. During family time, she says that, "We play games, we enjoy each other's company and we love watching movies." When with her friends "We usually do gymnastics (like mini games), make short movies or commercials." Her favorite food is pasta (Italian) and salad. Stacy's number one film is Hotel Transylvania because the movie is fun and cool. What grabs me are the voices of Selena Gomez and Ceelo Green. Her favorite actress is Meaghan Martin from Camp Rock. "She is a great actress," Stacy says, "She has that diva, sass and powder style." When Stacy grows up, she wants to be a scientist or doctor.. As a KIDS FIRST! Film Critic Stacy wants to be able to watch movies, look at the characters and to see different kinds of creations and actions. Morgan Bertsch, age 9, lives in North Hills, California with her parents. Her parents help her with homework, play ball and go to the movies. Morgan enjoys playing Nintendo DS, films on her DVD player and playing with her dolls. Morgan's favorite movie is Tangled because of her long hair. Her greatest accomplishment is graduating kindergarten. She is most looking forward to interviewing people and watching the new movies. Keefer Blakeslee, age 13, lives in the greater Los Angeles area, part time. He has three older siblings who are all married. His dad passed away six years ago so he and his Mom are enjoying their life together. They play chess, swim, skate, and watch and critique movies together. Keefer likes riding his bike, cooking, watching Nostalgia Critic on the Internet and reading his favorite book "Life Itself: by Roger Ebert." Keefer loves so many films it's difficult to pick one. If he had to, it would be The King's Speech because he could watch it again and again. It has amazing acting and an incredible story. It's also difficult for him to name a favorite actor but Mel Brooks and Jim Carrey would have to be at the top of the list. "They are both funny and great actors that really know how to capture their audience and make them laugh." When he grows up, Keefer wants to be an actor, comedian, critic, director, producer and screen-writer. He is most proud of proving to his mom that he deserved moving to California so he could pursue his career. His favorite film critics were Gene Siskel and Roger Ebert. "They were so entertaining. I loved listening to their reasoning and watching them bicker. I read Roger Ebert's film reviews to the day he died." As a KIDS FIRST! Film Critic Keefer enjoys being able to speak his own opinion to people who love movies because, "if you're going to pay to watch a movie, it had best be a good one!" He also found out how much he enjoys writing. Fifteen-year-old Victoria Burns lives in Atlanta, Georgia with her parents and two siblings, ages twenty-two and twenty. They enjoy going to the movies, trips to Barnes and Noble, reading and going out to eat. Victoria enjoys reading, going to the mall and going to movies with her friends. Her favorite movies are The Bourne Trilogy because each movie is as good as the first and leaves you wanting more. Her favorite actor is Denzel Washington because he can convincingly portray different types of characters. When she grows up Victoria wants to be a psychologist. Her greatest accomplishment is learning how to draw still life art. As a KIDS FIRST! Film Critic she enjoys going to movie screenings, interviewing actors and getting to give her opinion on the movies. Adam Chernick, age 8, hails from Tarzana, CA in the greater LA area. He has two older siblings, Mirabelle and Michael. He enjoys going to the aquarium, the science museum, visiting police and fire stations and going out to eat with his family. With his friends, he plays various games including baseball and soccer. Adam's favorite film is The Artist because he loves how cute and loyal the dog is. George Clooney wins his affection as his favorite actor and ice cream as his favorite food! Adam aspires to be a politician or work in law enforcement when he grows up. Adam is most proud of himself for how he handled changing schools this last year. He was very nervous and scared to go to a brand new school but, it worked out just fine. He also enjoyed appearing on Critics' Choice in 2012 as a mini Paul Scheer where he wore a bald cap. His best friend is KIDS FIRST! Film Critic Morgan Bertsch. Trivia about Adam: He has been stung by a bee four times! Ouch. What he enjoys most as a KIDS FIRST! Film Critic is seeing lots of new movies and interviewing people on the red carpet. Sixteen-year-old Raven Sky Devanney hails from Boulder, CO where she lives with her mom and 9-year-old brother. She has a slight menagerie of pets (3 cats, 2 dogs, 3 birds, and 3 fish: Luna, Mister, Playdough, Lady, Bo, Pickle Pie, Dave, and Peddie Jeffrey Longbottom.) Her favorite movies are Titanic and The Imagination of Doctor Parnassus. In her free time, Raven enjoys watching movies with her family, ice skating, playing basketball or dining on Ethiopian food. You might run into her shopping at the mall with her friends or find her writing, drawing or reading. Among her favorite books are Emily the Strange, The Giver and Skeleton Creek. Johnny Depp wins her heart as her favorite actor. She aspires to become an actress or model. The thing she likes most about her job as a KIDS FIRST! Film Critic: "Getting to share my opinions about the films I watch and interviewing people in the entertainment business. It's all very exciting!" Ten-year-old Cheyenne Nguyen lives in Fountain Valley, California with her mother and two brothers, ages sixteen and nineteen. Cheyenne and her family enjoy going to church, going to movies and going to parties. In her free time, Cheyenne enjoys watching new movie releases with her friends, playing "Dance Central" and singing. Her favorite movie is Despicable Me, because it is very funny. Cheyenne's favorite actress is Zendaya Coleman from Shake It Up, because she can relate to the character Rocky. When she grows up Cheyenne wants to be a news reporter, actor or singer. Her greatest accomplishment is keeping straight As in school. As a KIDS FIRST! Film Critic, Cheyenne enjoys meeting all the talent and being able to ask questions. Patrick Nguyen, age 15, is from Westminster, CA where he enjoys watching movies with his family, traveling, eating new foods and partying with his extended family who get together and sing karaoke and play board games. Patrick's favorite foods are tempura sushi, BBQ chicken pizza and tomato pasta. He loves shopping, going to the theater, go-carting and miniature golf. One of Patrick's favorite movies is Hairspray because there are so many known stars, great singing and history. "I enjoy the combination of Zac Efron, Queen Latifah and James Masden. They all have unique voices and the finale song is incredible." One of his favorite actors is Johnny Depp because of his versatility. "From Willy Wonka to Captain Jack Sparrow, all of his characters are well thought out and full of personality." Hugh Jackson is another favorite because of his proficiency in singing, dancing and acting. Patrick aspires to be an actor when he grows up although he realizes there are not a lot of Asian-American actors in this industry. His backup plan is to become a radiologist. One of Patrick's greatest achievements is to have been on Nickelodeon for a commercial called, "The Big Help." "When I was on set, I met so many friends with the same interests. We had a blast and it made me want to work my way up in the industry." Patrick enjoys the funny relationship between Billy and Kit on Access Hollywood. They are full of energy, have great chemistry and interview some of his favorite stars. What Patrick enjoys most as a KIDS FIRST! Film Critic is how he's learned to speak on camera, knowing what questions to ask and how to position yourself. He enjoys watching new movies and writing his own reviews and interviewing stars. Gerry Orz, age 12, comes from Rancho Palos Verdes, CA and has one older sibling, Dennis. He enjoys watching movies and football, cooking and traveling with his family, playing video games and is an avid filmmaker who writes and makes movies with his friends. Gerry's favorite film is Jack and Jill. His favorite actors are Ellen DeGeneres and Adam Sandler. Ellen because she is amazing, funny, smart and so kind. She inspired Gerry to believe in himself and try to make a difference in the world. As a result, he has produced a number of educational movies and created a non-profit organization called Kids Resource. Adam Sandler is his other favorite actor because "he is an amazing actor and comedian, always stays true to himself." Gerry is a huge fan of directors Steven Spielberg and George Lucas and he aspires to become a film director, producer and writer. "I want to make movies that will have a positive impact on today's youth and will inspire them to follow my footsteps to a better tomorrow." He is already off to a great start, having produced several films including a short, Day of Silence, that inspired a new bill in CA to proclaim 12/12/12 Bullying Prevention Day. Gerry received many emails thanking him for making that film. "We heard stories where parents believed that my movie saved their child's life." On 12/12/12 at 12 p.m., Gerry had followers in six states and four countries joining in a moment of silence. "I plan to expand in coming years and get more people on board to honor 12/12 and work towards making the world a better place." As a KIDS FIRST! Film Critic, Gerry enjoys learning more about movies and film making and improving his own movies so they can be included in the KIDS FIRST! Film Festival." Haley Powell, age 11, lives in Burbank, California with her family. She has an older sister (Christin, 25) and an older brother (Jordan, 13). Haley and her entire family enjoy movie nights together and she gets to spend special time with her mom to cook or play games. Haley's Daddy often takes her out to eat for Daddy date night. Her passion is dancing and she loves to make up dance routines with her cousins or friends. She uses her free time to write stories in her journal and play video games with her brother. Haley's favorite food is noodles, all kinds of noodles, give her oodles and she is happy. One of her favorite films is Akeelah and the Bee because it has to do with spelling bees and Haley loves to spell, write and speak. One of her favorite actresses is Leigh Allyn Baker who plays Amy Duncan on Good Luck Charlie. Haley appreciates her humor and how she is down to earth with her TV family. Haley says the silly things they do in the show remind her of her own family. When she grows up, Haley is interested in pursuing journalism, broadcasting and/or film directing. She eventually would like to write her own films and still find time to become a professional dancer. She is most proud of becoming a voice-over series regular in Fisher Price's Imaginext Adventures webisode and being a part of a voice-over team for the movies 12 Years a Slave and Best Man Holiday as well as doing voice over in the video game Final Fantasy XIII. In addition, she has a re-occurring role in a webisode called First currently airing on Isa Rae Network. Haley is also a FTS Kids News Reporter and a student council member at her school. As a new KIDS FIRST! Film Critic, she looks forward to meeting and interviewing celebrities, reporting from the red carpet at movie premiers, and watching, reviewing and reporting on the films she has seen. Kayla Powell, age 12, lives in Burbank, CA with her parents, her brother KJ and her twin sister Kendyl. When Kayla is with her parents, she likes to play games, watch movies, ride her bikes and practice acting. Her friends call her by her given name Kayla or the shortened version, Kay. When she is with her friends or alone, she likes to create dance routines, play games and style hair. Kayla's favorite movie is Frozen. In her opinion, it is hilarious and has a great message. She enjoys watching movies with a good message. Kayla's favorite actress is Zendaya Coleman because she is "an amazing actress and also a triple threat." Kayla enjoys eating different types of food but, her favorites are cheeseburgers and sushi. (Hopefully not together.) When Kayla grows up she would like to be an actress, orthodontist or both. She is very proud of the fact that by the age of 11 she was in Debbie Allen's, Hot Chocolate Nutcracker; has been in 2 movies; booked a national commercial, as well as a pilot; and is working with her brother KJ and sister Kendyl. Kendyl Powell, age 12, lives in Burbank, CA with her parents, brother KJ and sister Kayla. When Kendyl is with her parents she likes to watch movies, play board games, ride her bike and talk. Her friends call her Kendi. When she is with her friends, she likes to tell jokes, swim, act and be creative by creating crazy loom bracelets. Kendyl's favorite movie is Rise of the Guardians because "it has a lot of funny parts in it, while still being full of action." Kendyl's favorite actress is Raven-Simone. She enjoys watching the diverse emotions that Raven-Simone emanates while she is acting, especially when she is being comical. Kendyl is inspired by Raven-Simone's passion for acting. Kendyl loves eating different types of food, but her absolute favorite is lasagna. As a new KIDS FIRST! Film Critic Kendyl looks forward to watching new films, sharing her thoughts/opinions with others, and is excited to meet new people. When Kendyl grows up she would like to be an actress or dancer. She is very proud of the fact that by the age of 11 she was in Debbie Allen's, Hot Chocolate Nutcracker; has booked a pilot; and is able to play the French horn. Shelby Ronea, age 15, lives happily as an only child in Tampa Bay, Florida. It is clear that Shelby has a strong interest in films as shown by the many nicknames her friends have given her - Ms. Star, Film Queen, Ms. Drama. With her family, she enjoys doing aerobics, shopping, traveling and - surprise - watching films. She works with her friends to improvise games and skits or takes walks on the beach. When alone, Shelby enjoys knitting. Her favorite foods are Italian and seafood. Shelby's favorite film is Diary of a Wimpy Kid because the humor of the main character keeps her laughing throughout the film. Her favorite actress is Meryl Streep. In each performance, Shelby has noticed how Streep transforms herself into the character she is playing. Shelby says she would love to interview her. When she grows up, Shelby hopes to become an Oscar-winning actress. She is on her way as she has visited Paramount Pictures in LA and held an actual Oscar trophy and has completed her first support role in a movie starring Haley Joel Osment in September 2013. Shelby hopes that as a KIDS FIRST! Film Critic she will be able to assist her readers to understand the intentions of the director and the motivations of the actors. Simone Sharrieff, age 13, lives in Clermont, FL with an older brother, Kerry, age 28 and a younger sister, Layla, age 10. Family time is spent going to the movies, bowling and going to church. With her friends, Simone also enjoys going to the movies, making silly videos and playing in her school's symphonic and jazz bands. Alone, she loves to write in her journal and edit videos - as evidenced in her video reviews. Simone's favorite film is Princess Diaries because it stars two of her favorite actresses - Anne Hathaway and Julie Andrews. "It makes me believe that I could grow up and become a real princess. It's such a feel good flick!" When she grows up, Simone plans to attend film school and become a film director. Her greatest accomplishment so far is her academic performance. "I've made the all A or A/B honor roll every year since kindergarten. Being successful in academics is very important to me." She admires Leonard Maltin as a film critic and, as a KIDS FIRST! Film Critic, she looks forward to meeting and learning about all kinds of people. Justin Storey, age 16, lives in Orlando, Florida. Ever since he was a young boy he loved being the center of attention. Justin enjoyed sitting in front of the TV with his mom watching the news. He would hold his brush and mimic the reporter he saw on TV. When Justin got older he became interested in reporting and also acting. He got his first acting experience in school and church plays. Today, Justin has been appeared in commercials for brands such a Nissan, Carnival Cruise line, Disney World and many others. Along with commercials, Justin has recently appeared in television shows and films. Justin has a big future ahead and hopes to continue pursuing his passion of acting. When he's not in front of a camera he is busy writing his own films. He enjoys film-making and video-editing. Recently, Justin joined the KIDS FIRST! Film Critic team and hopes to gain more exposure and experience in reporting and journalism.
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Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01480050
Recruitment Status : Completed
First Posted : November 28, 2011
Last Update Posted : June 26, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Mibefradil dihydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This phase I trial is studying the best dose of mibefradil dihydrochloride when given together with temozolomide in treating patients with glioma.
|Condition or disease
|Brain and Central Nervous System Tumors
|Drug: temozolomide Other: 3'-deoxy-3'-[18F]fluorothymidine Other: pharmacological study Drug: Mibefradil
|Phase 1
- Determine the maximum-tolerated dose (MTD) of mibefradil dihydrochloride administered prior to five days of temozolomide (TMZ) at 150-200 mg/m² in subjects with progressive or recurrent high-grade glioma.
- Assess the safety of mibefradil dihydrochloride administered prior to five days of TMZ at 150-200 mg/m² when the mibefradil dihydrochloride dose is escalated from a starting dose of 100 mg/day, given four times a day for seven consecutive days.
- Determine the pharmacokinetic profile of mibefradil.
- Determine the steady state levels of mibefradil dihydrochloride on the last day of dosing.
- Assess the severity and frequency of adverse events for tested mibefradil dihydrochloride dose levels including cumulative toxicity and/or tolerance to adverse effects.
- Estimate the number and type of radiographic responses to treatment with mibefradil dihydrochloride and temozolomide.
- Assess the potential effect of mibefradil dihydrochloride on tumor metabolism as determined by Fluorothymidine Positron Emission Tomography (FLT PET) scans with the radiotracer [18F]-3'-fluoro-3'-deoxy-L-thymidine (dose-expansion cohort only).
OUTLINE: This is a dose-escalation study of mibefradil dihydrochloride followed by a dose-expansion study.
Patients receive mibefradil dihydrochloride orally (PO) 4 times a day on days 1-7 (days 1-8 on first course) and temozolomide PO on days 8-12 (days 9-13 on first course). Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Blood samples are collected during the first course for pharmacokinetic studies.
Patients in the dose-expansion cohort undergo [18F]-3'-fluoro-3'-deoxy-L-thymidine (FLT)-positron emission tomography (PET) at baseline and on day 7 of the first course of therapy.
After completion of study therapy, patients are followed up every 2 months.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|28 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Open Label Safety Study to Evaluate the Pharmacokinetic Profile and Tolerance of Mibefradil Dose Finding in Subjects With Recurrent High-Grade Glioma Undergoing Standard, Repeated Temozolomide Treatment
|Actual Study Start Date :
|April 2012
|Actual Primary Completion Date :
|August 2015
|Actual Study Completion Date :
|June 1, 2017
Experimental: Dose Finding
Dose Escalation of Mibefradil for 7 days followed by TMZ (150-200mg/m2) every 28 days. At MTD 10 additional pts treated with an addition FLT PET-CT scan.
Mibefradil Temozolomide (TMZ) FLT PET CT '3'-deoxy-3'-[18F]fluorothymidine' Pharmacology Studies
Drug: temozolomide
Other: 3'-deoxy-3'-[18F]fluorothymidine
tracer used for FLT PET CT
Other: pharmacological study
Drug: Mibefradil
- Maximum-tolerated dose of mibefradil dihydrochloride [ Time Frame: 2 years ]
- Dose-limiting toxicity [ Time Frame: 2 years ]
- Toxicity and adverse events according to CTCAE v. 4.0 [ Time Frame: 2 years ]
- Biological activity of treatment determined by radiographic response [ Time Frame: 3 years ]
- Pharmacokinetics of mibefradil dihydrochloride [ Time Frame: 2 years ]
- Potential effect of mibefradil dihydrochloride on tumor metabolism as determined by [F-18]FLT PET scans in the dose-expansion cohort [ Time Frame: 6 months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 120 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Histologically proven high-grade glioma (glioblastoma, anaplastic astrocytoma, anaplastic oligodendroglioma, mixed anaplastic oligoastrocytoma, anaplastic ependymoma) that is progressive or recurrent following standard upfront radiation therapy + temozolomide
- Measurable contrast-enhancing progressive or recurrent high-grade glioma (single or multiple lesions) by MRI imaging within 30 days of starting treatment
Must have a plan for retreatment with temozolomide at 150-200 mg/m² for 5 days per cycle; each cycle = 28 days
- Must have previously tolerated at least one cycle of adjuvant temozolomide therapy in the prior treatment of the glioma
- Karnofsky performance status ≥ 60%
- Hemoglobin ≥ 9 g/dL
- Absolute neutrophil count ≥ 1,500/µL
- Platelets ≥ 100,000/µL
- Total bilirubin < or equal to 3 times institutional upper limit of normal (ULN)
- AST(SGOT)/ALT(SGPT) < or equal to 3 times ULN
- Creatinine normal OR creatinine clearance ≥ 50 mL/min
- Serum potassium, magnesium, and calcium levels normal (may be corrected to those levels by supplementation during screening period)
- Not pregnant or nursing
- Negative pregnancy test
- Women of childbearing potential and men must agree to use adequate contraception
Able to tolerate MRIs
- CT scans cannot be substituted for MRIs in this study
No concurrent malignancy except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix, breast, or bladder
- Subjects with prior malignancies must be disease-free for ≥ five years
- Mini-Mental State Exam score of ≥ 15
- Patients must identify a caregiver/support person who will agree to assist with the remote cardiac monitor and taking/recording blood pressure at home
- No serious concurrent infection or medical illness, which would jeopardize the ability of the subject to receive the treatment outlined in this protocol with reasonable safety
- No uncontrolled intercurrent illness including, but not limited to, hypertension, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- No history of known, active hepatitis
- No screening QTc interval ≥ 450 mSec for males or 470 mSec for females
- No PR interval > 250 mSec
- No systolic blood pressure < or equal 100 mm Hg at baseline
- No history (within six months) of myocardial infarction, unstable angina, uncontrolled hypertension, or congestive heart failure
- No high-grade (second degree or above) AV block or persistent sinus bradycardia of less than 50 BPM
- No known HIV-positivity
- See Disease Characteristics
- Recovered to CTCAE grade < or equal 2 from toxicities related to prior therapy
An interval of at least 3 months must have elapsed since the completion of the most recent course of radiation therapy, the last dose of temozolomide (TMZ), or placement of Gliadel wafers
- No prior cytotoxic therapies other than temozolomide and Gliadel wafers
- Prior anti-VEGF therapies are allowed if more than four months have elapsed from the end of prior treatment
- 30 days must have elapsed since previous treatment of the brain tumor with any other agents
- Must be maintained on a stable or decreasing corticosteroid regimen (no increase for 7 days) prior to the start of treatment
- Patients may not be receiving any other investigational agents or chemotherapeutic agents other than temozolomide
- No anti-arrhythmia medication other than beta-blockers or digoxin
No requirement for a calcium channel blocker for blood pressure control that cannot be switched to an antihypertensive with an alternative mechanism of action
- Permitted anti-hypertensive medications include: chlorothiazide, hydrochlorothiazide, atenolol, nadolol, enalapril, lisinopril, eprosartan, and irbesartan
- Patients cannot receive any statin while on trial except pravastatin
No treatment with an H2 blocker, other than famotidine
- If the patient requires a proton pump inhibitor (PPI), then esomeprazole, pantoprazole, or rabeprazole may be given
No concurrent enzyme-inducing anti-epileptic drugs (EIAEDs)
- Patients previously treated with EIAEDs may be enrolled if they have been off the EIAED for 10 days or more prior to the first dose of mibefradil
Patients taking an anticoagulant must use warfarin or a low molecular weight heparin
- Unfractionated heparin is not permitted
- No drugs that are substrates of CYP3A4, CYP2D6, and CYP1A2 except for the ones that are explicitly permitted
- No drugs that have potential to interfere with metabolism or excretion of mibefradil
Patients who are taking and cannot discontinue over-the-counter (OTC) medications and nutritional supplements, including herbal or "Chinese" medications, are not eligible, except for the following:
- OTC medications that are allowed at labeled doses during dosing with mibefradil are acetaminophen, aspirin, diphenhydramine, calcium carbonate antacids, branded multiple vitamin supplements and pseudoephedrine
- Topical preparations and decongestant nasal sprays are allowed
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01480050
|United States, Alabama
|UAB Comprehensive Cancer Center
|Birmingham, Alabama, United States, 35294-3410
|United States, Georgia
|Winship Cancer Institute of Emory University
|Atlanta, Georgia, United States, 30322
|United States, Maryland
|Johns Hopkins University
|Baltimore, Maryland, United States, 21205
|United States, Michigan
|Henry Ford Hospital
|Detroit, Michigan, United States, 48202
|United States, North Carolina
|Wake Forest University Comprehensive Cancer Center
|Winston-Salem, North Carolina, United States, 27157-1096
|United States, Pennsylvania
|Abramson Cancer Center of the University of Pennsylvania
|Philadelphia, Pennsylvania, United States, 19104-4283
|Hillman Cancer Center at University of Pittsburgh Cancer Institute
|Pittsburgh, Pennsylvania, United States, 15232
|Principal Investigator:
|Matthias Holdhoff, MD
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
|Responsible Party:
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
|ClinicalTrials.gov Identifier:
|NCT01480050 History of Changes
|Other Study ID Numbers:
|First Posted:
|November 28, 2011 Key Record Dates
|Last Update Posted:
|June 26, 2018
|Last Verified:
|June 2018
Keywords provided by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins:
adult giant cell glioblastoma
adult glioblastoma
adult anaplastic astrocytoma
adult anaplastic ependymoma
adult anaplastic oligodendroglioma
adult mixed glioma
recurrent adult brain tumor
Additional relevant MeSH terms:
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms by Site
Nervous System Diseases
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Antiviral Agents
Anti-Infective Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Anti-Retroviral Agents
Antihypertensive Agents
Calcium Channel Blockers


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Definition of dev
n. - Alt. of Deva 2
The word "dev" uses 3 letters: D E V.
No direct anagrams for dev found in this word list.
Words formed by adding one letter before or after dev (in bold), or to dev in any order:
a - deva i - dive vide vied l - veld n - vend o - dove s - devs
Shorter words found within dev:
de ed
Words formed from any letters in dev, plus an optional blank or existing letter
List all words starting with dev, words containing dev or words ending with dev
All words formed from dev by changing one letter
Other words with the same letter pairs: de ev
Browse words starting with dev by next letter
Previous word in list: deutzias
Next word in list: deva
Some random words: dhak jnana luau nth irk rhabdocoele owing
This is not a dictionary, it's a word game wordfinder.
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The price of the humble Irish potato has rocketed by 85 per cent – thanks to a dreadful winter.
As the summer finally threatens to arrive, Irish consumers are paying a hefty price for the unseasonal cold.
The Irish Independent reports that families have been hit with a 10pc hike in the cost of locally produced food because of the cold winter and delayed spring.
And the potato has suffered the most with Central Statistic Office figures showing that a 10kg bag of spuds has risen in price from €5.06 to €9.34 – or by 85 percent.
The paper says further hikes are likely to follow thanks to the bitterly cold start to the year and the subsequent late spring.
Home-grown crops are taking longer to ripen and come to market which will lead to higher prices.
The report adds that beekeepers have also warned there is a real threat to honey supplies this year due to a combination of disease and bad weather.
One beekeeper in Westmeath has even warned he does not expect to produce any honey this year as his bees have been unable to mate, resulting in hives being decimated and less honey being produced.
The Federation of Irish Beekeepers' Associations, which has 2,500 members, told the paper that the problem was weather related.
Midlands branch secretary Jim Donohoe said: "We've had bad summers before, but because of the wind, rain and lack of sunshine, we've had serious problems with colonies wanting to swarm, but the queens being unable to mate with drones which refused to fly because there wasn't calm conditions.
"This year, we had a delayed winter where bees couldn't fly. The flowers were delayed coming out, and that crucial period meant bees died from old age. All of this combines to about 50pc of colonies being lost. If we don't get milder weather, the losses will be closer to 75pc.
"The possibility for re-building is almost zero for this year."
The report states that the losses have had knock-on implications for the wider agricultural sector, as bees play a critical role in pollinating many crops.
Last year's poor summer, coupled with a long winter in which temperatures plummeted to the lowest on record in March, have delayed the growing seasons.
CSO figures show the highest increases have been in potatoes (up 85 percent), broccoli (20 percent), brown flour (17 percent), topside or rib roast beef (14 percent) and a kilogramme of pork sausages (13 percent).
Rises have also been recorded for white flour, chicken, tomatoes, carrots, pork, ham, eggs and mushrooms.
A spokesman for the Irish Farmers' Association warned: "There's price volatility, and there will be into the future. The big story for us this year is going to be the extra cost of producing food because of the extraordinary weather and the poor harvest last year.
"There is a very severe cost pressure on producers because they have to buy feed in the middle of May and the repercussions will be felt for some time to come."


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AuburnCurrent coach: Tony BarbeeI'm a little upset they didn't think Pearl would work here. And Howland definitely recruited Georgia well, but he flat out screwed up his home base recruiting. Still, I'd be ecstatic over that kind of hire, if it came down to that.
Replacement: Bruce Pearl
Skinny: This could be a make or break year for Barbee. He's gone just 35-59 in three seasons at Auburn – and Pearl's show-cause penalty from the NCAA ends soon. In Pearl's 19 seasons as a college head coach, he never had a losing season – including six straight NCAA tournament appearances with Tennessee. He could jump at the opportunity.
GeorgiaCurrent coach: Mark Fox
Replacement: Ben Howland
Skinny: This one could be interesting. Fox reached the NCAA tournament back in 2011, but is now coming off back-to-back 15-17 campaigns with the Bulldogs. They're not supposed to do much this season, either. Would Howland be a good fit in Athens? He recruited Georgia well while he was at UCLA and could be looking to get back in the mix.


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|International Space Station Imagery
high res (0.5 M) low res (57 K)
|ISS007-E-13829 (30 August 2003) --- Backdropped by a blue and white Earth, an unpiloted Progress supply vehicle approaches the International Space Station (ISS). The Progress 12 resupply craft, which launched from the Baikonur Cosmodrome in Kazakhstan at 8:48 p.m. (CDT) on August 28, 2003, carried nearly three tons of food, fuel, water, supplies and scientific gear for the Expedition 7 crew aboard the Station. The Progress linked up with the Station at 10:40 p.m. (CDT) on August 30, 2003 as the two spacecraft were flying over Central Asia at an altitude of 240 statute miles.
Curator: JSC PAO Web Team | Responsible NASA Official: Amiko Kauderer | Updated: 10/30/2012


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Hello Daily Celebrity Crossword Fans!
Today is 3 February 2018 and we have given the solutions for Daily Celebrity crossword puzzle! Check our best answer below..
CROSSWORD CLUE: Square footage
Solution: Area
Part Of: Daily Celebrity ,3 February 2018
We have tried to include a lot of puzzles & clues but if you feel that we have missed out with the given clue "Square footage", then send us an email or leave a comment and we will do the necessary changes at the earliest.