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Dr. Paget: It is a pleasure today to introduce today Dr. Sergio Schwartzman, a Clinical Associate Professor of Medicine at the Weill Medical College of Cornell University. Dr. Schwartzman is a superb rheumatologist, but also has a an interest in inflammatory diseases of the eye, an important focus for our patients who develop these types of problems.
Dr. Schwartzman, why is the eye important to a rheumatologist and to a primary care physician?
Dr. Schwartzman: Although autoimmune diseases of the eye are relatively uncommon, when they occur they clearly have a very important impact on morbidity and, at times, mortality. Further, effects secondary to some of the medications that are used to treat them can at times be very important. Various types of autoimmune disease affect the eye. By far and away, the most common is uveitis. Uveitis is a disease that has many clinical features and is separated into three types:
There can be an overlap, and there are conditions in which there is involvement of all of the chambers - what we call pan-uveitis. The symptoms of these different manifestations differ somewhat, but again, they can overlap.
In anterior uveitis, photophobia, eye tearing and occasional eye pain occur. Vision is not dramatically impaired, but can be impaired if this condition becomes chronic. In intermediate uveitis, patients complain of floaters or occasional decreased visual acuity. In posterior uveitis, you have similar symptoms with a decrease in visual acuity.
We also know that uveitis can exist as an independent disease or as an illness that is associated with other autoimmune diseases which the rheumatologist frequently sees.
Dr. Paget: Could you give some examples of disorders that the rheumatologist deals with that are most characteristically associated with uveitis?
Dr. Schwartzman: Sure. About half of the time, uveitis occurs as an independent disease. The remaining 50% of cases of uveitis can be associated with other illnesses. It is very important, however, before we consider rheumatic diseases, to exclude infectious illnesses such as CMV, herpes, toxo, TB, and syphilis, and to exclude malignant diseases. Lymphoma can effect the eye in a way that may mimic uveitis.
The most common diseases that a rheumatologist sees that result in uveitis are ankylosing spondylitis, juvenile rheumatoid arthritis, Behcet's disease, and all of the HLA B-27 associated seronegative spondyloarthropathies.
Dr. Paget: What about the vasculitides that we deal with, such as granulomatosis with polyangiitis and polyarteritis nodosa?
Dr. Schwartzman: Those don't tend to result in uveitis. They can, however, affect the eye, as can lupus and antiphospholipid antibody syndrome. These tend to predominate to a somewhat greater extent in the retina, but can affect the eye as well in other areas.
Dr. Paget: Is it absolutely mandatory to have an ophthalmologist involved in the care of somebody with these types of problems?
Dr. Schwartzman: It is not only critical to have an ophthalmologist involved, but I think it's critical to have an ophthalmologist who is familiar with autoimmune diseases and involved in the care of these types of patients. The rationale for this is that when one determines therapy, the barometer for deciding how aggressive to be is clearly the ophthalmological examination. One can actually quantify uveitis by counting cells through the slit lamp (high magnification eye microscope). The numbers of cells present reflect the activity of the disease.
Dr. Paget: So there are probably two different types of people: those who are sent to you by an ophthalmologist, and those whom you are already treating who develop a problem and may be sent to an ophthalmologist. Is there a different algorithm of care and evaluation in each one of those?
Dr. Schwartzman: I think the algorithm is relatively similar. However, there is an important difference. Most of the patients that we detect as having autoimmune disease affecting the eye tend to have relatively mild eye disease and established systemic autoimmune disease. The most common condition is ankylosing spondylitis, where as many as 20-40% of patients who have that disease will at some point in their lives experience anterior uveitis; in that circumstance, the uveitis is relatively mild. It is short-lived. It's unilateral, and it is treated with topical agents.
The patient that the ophthalmologist refers to us for care, however, is usually a patient that can have one of many diseases affecting the eye, but one that has been resistant to therapies that the ophthalmologist is comfortable with.
The ophthalmologist does not have the experience that we as rheumatologists have treating with these very aggressive immunosuppressive agents. So I would say that the clinical experience is different. The algorithm, which is not really developed - although it is something that potentially would be helpful on this group of diseases - is relatively the same.
Dr. Paget: For the primary care physician and the rheumatologist out there, what does the evaluation consist of? Obviously, you do a complete history and physical, because you need to rule out the systemic diseases and comorbidities. Are there specific tests that you do on people with "unknown" causes of uveitis?
Dr. Schwartzman: I think that the preliminary evaluation, in addition to the careful history and physical exam, would require the following: a PPD (purified protein derivative skin test), syphilis serologies, chest x-ray, and routine laboratory tests. I think that at times we need a little bit more of an extensive type of diagnostic work-up. In certain circumstances, dictated by the careful history and physical exam, a more extensive work up needs to be undertaken. For example, if a patient has a history of bloody diarrhea, an evaluation for colitis needs to be done.
Dr. Paget: Two disorders that you haven't mentioned as yet, Lyme disease and sarcoidosis, are often discussed with regard to the differential diagnosis of uveitis. How common are those, and do you evaluate those patients for the presence of those disorders?
Dr. Schwartzman: I think Lyme disease can clearly cause uveitis. It is one of the infectious etiologies, and there are probably at least 10 diseases that we can name that are infectious and can cause uveitis, but it is very uncommon. Sarcoidosis is somewhat more common. The pattern is relatively pathognomonic. These patients develop bilateral pan-uveitis. It can have a nodular type of pattern that is sometimes noted. If the history is suggestive, clearly a diagnostic evaluation for these conditions needs to be carried out.
Dr. Paget: So, once you have made the diagnosis, whether you've seen them initially or they've been referred by an ophthalmologist, what are the parts of the armamentarium that you have available, from the mildest to the most significant, with regard to controlling this potentially blinding problem?
Dr. Schwartzman: I think your point about the blinding issue is important to recognize. Although I've mentioned that uveitis is a relatively uncommon disease, even for the ophthalmologist to see, it accounts for 10% of significant visual loss in the United States. So it has a very high degree of morbidity. In addition, some of the agents that we use to treat this, which we will discuss, can result in further morbidity. Cataracts and glaucoma are not infrequent in patients with uveitis secondary to steroids.
In terms of our armamentarium, cycloplegic agents and topical steroids are really the first line and, in most patients with uveitis, that will usually be successful in treating the disease, particularly anterior uveitis. Posterior uveitis, chronic uveitis, and intermediate uveitis generally require a more aggressive approach. The current recommendations are that systemic steroids be utilized first -- prednisone at a dose of 1 mg per kilogram, which is then adjusted based on what the ophthalmologist sees. If the ophthalmologist sees rapid improvement, one is relatively safe in tapering the steroid slowly.
In patients who don't respond to corticosteroids, there isn't an established, agreed-upon paradigm. However, there are certain medications that we utilize commonly. These include Methotrexate, Mycophenolate, Azathioprine, and Cyclosporin. Cyclophosphamide (Cytoxan) has been used to treat uveitis both orally and systemically, and pulse steroids - that is, 1 gram of methylprednisolone (Medrol) a day for three days in a row - has also been used. These two therapies are less frequently used today.
Although gammaglobulin and several biological therapies have been used experimentally for the treatment of chronic "resistant" uveitis, the greatest emphasis over the last 8 years has been on the use of anti-TNF agents.
Dr. Paget: What are the anti-TNF agents you are talking about?
Dr. Schwartzman: Although all three of the anti TNF agents - etanercept, infliximab and adalimumab - have been used to treat resistant uveitis, it is now clear that only the monoclonal antibodies - infliximab and adalimumab - are efficacious. Clearly, etanercept should not be used to treat this group of diseases. Further, surprisingly and disturbingly there has been a recent paper published in Ocular Immunology and Inflammation on etanercept-associated inflammatory eye disease where several cases of inflammatory eye disease may have been precipitated paradoxically by etanercept.
Dr. Paget: Now, would these be for everyone with uveitis, so as to improve the overall outcome in that 10% of patients with blindness caused by uveitis, or is that just a subset of people who are refractory to the prior medications you are talking about?
Dr. Schwartzman: I think that is a very good question. The answer is, we don't yet know. Infliximab and adalimumab are not currently first line therapies for resistant uveitis. I can tell you that the way the studies are being organized is similar to the studies that were done for biological agents in rheumatoid arthritis. The first group of patients who are being subjected to these agents are patients who have been resistant to all other therapies for uveitis. My sense is that if biologics work in uveitis in the same way that we have seen in rheumatoid arthritis, we will likely see the same pattern of treatment as in rheumatoid arthritis; and that pattern, as you know, is that biologics are beginning to be used much earlier in treating patients with rheumatoid arthritis. I think that the same pattern will occur in uveitis. Interestingly, infliximab was recently approved in Japan for Behcet's-associated uveitis.
Dr. Paget: So we will try to profile people, and if they have certain characteristics that make it seem as though they are moving towards the blindness potential, we might very well act earlier, just like in rheumatoid arthritis with a person with aggressive disease that may eventuate a joint replacement.
Dr. Schwartzman: That's correct. I think we will have similar types of problems in terms of prognosticating which patients are more likely to develop blindness and visual impairment. For example, we know that patients with pan-uveitis or posterior uveitis are more difficult to treat. And I think that those factors, whether they be clinical or ultimately genetic, will be defined as we move forward.
Dr. Paget: And what do you see for the future -- more biologics, using them in combinations?
Dr. Schwartzman: I think that the current approach is to use them in combination with an immunosuppressive agent such as methotrexate or mycophenolate. As this field expands, my hope is that we will have more specific agents. There are animal models of uveitis in which cytokines have been identified which can probably promulgate uveitis, and in those studies there have been high levels of TNF, but there have been other cytokines as well.
I suspect that in some patients with uveitis there will be one or two cytokines that drive the disease, whereas in other patients, the cytokine profile may be completely different. It is going to be difficult to sample that from the eye, but I think there may be a better approach from a genetic perspective.
Dr. Paget: Thank you very much, Dr. Schwartzman.
Updated: 6/7/2007
Dr. Schwartzman was interviewed by Dr. Stephen A. Paget, Physician-in-Chief Hospital for Special Surgery


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I am into Maxi dresses this season...I think they are easy to wear, and could be flattering to any shape and size as long as we can find or choose the prints and structure. I think the bolder the print or color the less accesories should be worn. You dont wanna overwhelm the look and stay focus on the dress;)
I love that maxi dresses are versatile can be worn al year round, spring summer and fall! Its bold and easy !

subset: commoncrawl


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A stroller-friendly race is a running race that allows parents to walk, jog or race with a stroller – preferably a jog stroller.
As a parent, you go from school pickups to play dates to sports practices at lightning speed. In the non-stop race that is parenting, it's nice to be rewarded with a finish line. That's why we started to identify family-friendly races as well to balance sane parenthood with competition.
A kid-friendly race is a race designed specifically for children, from ages 6 mos. old through 12 years old. To include, but not exclusive to, diaper dashes, kids' dashes, and mile runs. We are seeing more and more races adding kids' dashes to their race weekends.
We scour the internet everyday looking for stroller-friendly and family-friendly races, results, and clubs to add to our directory. If your race or club should not be listed here for any reason, please let us know, and we will remove it. And if your race is not listed here, please let us know and we will add it.
Copyright © 2013 Run Stroller Run.
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Given the overwhelming success of the HauteGREEN show this year, and the increasingly large numbers of designers participating, we felt it was time to apply our 'editors-choice-awards' model to HauteGREEN and give a shout-out to the designs that really stood out as shining examples of good green design. Given how many designers participated in this year's HauteGREEN, it's hard to narrow down all the awesome green designs to just a few worthy of a Best In Show award, but a few do stick out in our mind as truly exceptional.
Here are our Inhabitat-editor-chosen awards for HauteGREEN 2007 Best In Show…
MOST GROUNDBREAKING DESIGN PROCESS: Cohda's RD4 Chair
Codha's brilliant RD4 Chair is made by melting and crushing recycled plastic bottles down into a thin plastic ribbon, which is then wrapped around a mold, roughly "sketching" the shape of a traditional chair. This gives the RD4 Chair its name: RD stands for "roughly drawn". These surprisingly comfortable chairs are made from 100% recycled waste plastic and bring an interesting new concept to the idea of recycling. Definitely one of the stand outs of the Haute GREEN show, we applaud COHDA's Richard Liddle and Sarah Blood for their truly future-forward design concept.
MOST USEFUL DESIGN INNOVATION: XDesign's 'Green Light' Plant Lamp/Air Purification System
We had our eye on xDesign's ingenious 'Green Light' Plant Lamp ever since we got a sneak peek of the work back in April. We were totally taken with the brilliant idea of combining indoor illumination with plant growing and air filtration, and think that xDesigns have done a fabulous job at turning what could be a somewhat complicated idea into a simple and elegant design solution. The 'Green Light' plant lamps on display at Haute GREEN were more varied and more beautiful than the early press photos indicated, and we were thoroughly impressed by how well the conceptual idea translated into a beautiful and useful design object. We can't wait until these puppies come to market.
MOST BEAUTIFUL RECLAIMED DESIGN: Michelle Brand's Cascade Lamp
Michelle Brand's gorgeous Cascade Chandelier was one of the highlights of Haute GREEN for us – in part because it totally caught us off guard. We never imagined that something so simple, cheap and ordinary such as reused plastic drinks bottles could be so easily turned into a such a stunning and elegant piece of interior design. More than any other piece in the Haute GREEN show, Michelle's Cascade Chandelier fully embodies the DIY spirit of Reclaimed Design, as well as eco-chic ethos of the Haute GREEN show. Well done Michelle! We can't wait to see more from you.
CRAFTIEST CRAFT: Unblossom Doily Bowl by The Home Project
We love the intersection of nostalgia and modern-day design, and these salt-crystallized doily bowls are a perfect example. We're seeing more and more references to traditional craft in design these days, and The Home Project does a great job of making your grandmother's doilies into something truly stunning.
BEAUTY IN SIMPLICITY Paul Loebach's Mirror Mirror
Who's the fairest of them all? As far as mirrors go, Paul Loebach's Mirror Mirror may very well take the cake. Its intricate design is secondary to its clever and uber efficient use of wood, which produces two mirror frames in a single cut (one is the removed piece of the other).


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Just not as good as THE PENGUIN!
Because I'm an artist too....
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pretty nice looking mecha man.
keep it up.
keep it up.
original gundam series rule.
my site www.ericguoart.com
my site www.ericguoart.com
Not taking any orders, but the TR-7D is now available for viewing
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Roads, Highways and Bridges
Steel Structure
Web Designing
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Charter Yacht Agencies
Health Services
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Environmental Consultants
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Fresh Meat Retail
Shade Net Manufacturers
Networking Lan/ Wan
Computer Games
Risk Insurance
Pipeline Services
Digital Media & Art Center
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Commercial Vehicles On Rent
Defensive Driving Training
Installation Of Heating
Lighting Consultants
Water Fountain Contractors
Club Cars
Fitness Centre For Children
Contractor Cable Networking For Commercial
Retail and Maintenance of Devices Broadcasting
Motorcycles Repair
Wedding Organizing
Owner Representative
Migration Services
Trailer Dealers
Project Planning and Developme
Sell & Buy & Repair Desktops
Portable Steam Injection
Tempered Glass
Liability Insurance
Mattress Manufacturers
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Cooler Chambers
Gas Pipeline Engineers
Fitness Item
Satellite Transmission Reception Equipment
Smart Forms Typing
Corporate And Promotional Gifts
Banking Lawyers
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Activity Clubs
Cyber Cafes
OHL Projects
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JCB Hydraulic Hose
Auto Music System - Repair, Installation and Sale
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Digital Advertising
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Sailing School
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Attending Operation and Maintenance Period
Batten Fittings
Motorcycle Spare Parts
Glass Film Dealers
Automobile Battery Dealers
Printing and Designing
Animal Feed
Leather Sign
Piping and Flowline Projects
Extension of The Oil Pipeline
Window Films
Repair Bicycles
Project Identification and Feasibility Studies
Flood Lights
Welding Job Work Ultrasonic
Turnery Workshop
Media Production
Air & Sea Consolidation
Pathology Lab
Rubber Stamp Making
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Well Design & Construction
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Audio Cassettes
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Stationery Division
Aviation Course
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Retail - Wedding Accessories
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Value Engineering
Ladies Hostel
Fire Pumps
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Decorative Stone
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Research Services
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Specialist Mounting
Paint Spray Booths
Envelope Typing
Foundation Work
Electronic Spare Parts
Document Imaging
Administration Office
Coffee Pods
Screen Graphic
Spices Mill
Check Up Car By Computer
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Omani Foods
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Designer Fountain Dealers
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Manufacturing Tar
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Design and Brand Specialists
3D- Sign , Plastic Sign, Wood, Neon Sign
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Media Representatives
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Chemical Store
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HP Service Center
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Business Skill Course
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Money Changers & Exchange Dealers
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Fitness Center For Women
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Gold and Silver Smith
Carton Coding & Sealing Machines
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Restoration of Historic Buildings
Wood Product Exporters
PRO Services
Electrical Contracting & Mechanical
Services for Oil Andggas Extraction
Water Well Drilling
Aircraft Charter, Rental & Leasing Service
Bus Tours
Decorative Concrete Manufacturers
Conceptual Design / Pre-FEED
Pashmina Scarves
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Shoes - Repair
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Ceramic Tile Contractors
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Manufacturer of Wood Flooring
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Hitachi IJ Printers
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Power Network
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Design - Multidisciplinary
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Social Club
Shahtosh Scarves
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technical Support
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metal products
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Online Buy & Sell
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paint and decor services
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text:
Forge of Empires - More Details Emerge
- By: Rich
- Posted 30th Jan 2012
Forge of Empires
More information about the rare good, trading system and city construction has emerged for InnoGames' latest browser based strategy game, Forge of Empires.
InnoGames are currently accepting pre-registrations on it's official website for the game: http://www.forgeofempires.com.
Rare resources like glass, copper or iron are important to players progress and vital to a peaceful way of playing. Several production buildings and varying supplies of 22 different goods add to the challenge. Players must undertake various tasks including research, trade, warfare and tactical battles, all of which are necessary to lead a Stone Age village through various epochs and transform it into an impressive and prosperous city.
Rare Goods Screens
Aspiring architects and city-planners have to juggle several factors; residential and production buildings provide coins and supplies, as well as housing space to accommodate an ever-growing population. Military buildings allow players to recruit troops to defend their city and conquer neighbor provinces. Goods Buildings produce rare resources like marble or honey, which can be used for trading and diplomacy, in order to keep citizens happy, however, players must also consider community and cultural buildings, such as schools, theaters and, later in the game, much grander structures like Castles and Cathedrals.
City Building Screens
Players gain access to several supplies of raw goods, such as wool or trees, by conquering provinces on the world map. Resources can be refined to rare goods, like lumber or cloth, but as every resource needs its own production building, the outcome is largely dependent on the supplies at hand and trade with other players is important. Obtained resources can be used to unlock new technologies on the research tree and to negotiate with NPCs. By fulfilling their demand of resources, peacefully-minded players can endeavor to assimilate provinces without bloodshed.


text:
Boss: Manning wasn't too mentally unstable to work
Army Pfc. Bradley Manning's violent outbursts and a photo of him dressed as a woman ideally should have blocked him from working with classified information in Iraq, but the Army needed his skills, the soldier's former boss testified Tuesday.
Retired Sgt. 1st Class Paul Adkins testified as a defense witness at the sentencing hearing for the former intelligence analyst. Adkins said that in April 2010, Manning emailed him a picture of himself in a blonde wig and lipstick attached to a letter titled, "My problem." Defense attorneys have characterized the email as a sign of the soldier's gender-identity crisis at a time when homosexual soldiers couldn't serve openly.
The emailed started: "This is my problem. I've had signs of it for a very long time. It's caused problems within my family. I thought a career in the military would get rid of it. It's not something I seek out for attention. And I'm trying very, very hard to get rid of it by placing myself in situations where it would be impossible. But it's not going away."
Manning was convicted of disclosing reams of classified information through WikiLeaks. He faces up to 90 years in prison.
Adkins, who handled administrative duties for Manning's workgroup, testified Manning's "mental instability" was "a constant source of concern." But instead of initiating disciplinary action that could have led to suspension of Manning's security clearance, Adkins urged psychiatrists to give him more treatment so he could keep working.
Adkins didn't' reveal the email to his commanders until June 2010, after Manning had punched a female soldier in the face and been arrested for leaking classified information.
Adkins and others have testified the unit deployed with a shortage of junior intelligence analysts, such as Manning, to help commanders understand the enemy's tactics.
"In a perfect world, I think, if I could have left him behind, to make sure that he was getting behavioral health care on a consistent basis, I would have," Adkins said.
He said "there was the indirect pressure of making sure everyone who could physically deploy was deploying." Adkins said another member of the unit was unable to deploy because of a recent heart attack, and he couldn't justify holding Manning back "especially with a non-physical health issue."
In a series of memos to mental health workers, Adkins described Manning's worrisome behaviors, starting with an angry outburst after he was scolded for missing a physical training formation in the summer of 2009, and another when he was disciplined for losing his room key.
In December 2009, about two months after deploying, Manning was scolded for tardiness and overturned a table and had to be restrained. Because someone suggested he had made a move toward a gun rack, Adkins removed the firing bolt from Manning's rifle but allowed him to keep working.
"I wasn't 100 percent sure of his stability and I wanted to send him a message that behavior like that, you know, was not acceptable," Adkins said.
Adkins testified he was reprimanded and demoted for failures involving Manning.
Under cross-examination, Adkins testified that the early outbursts were minor misconduct. He also said he took other measures aimed at reducing Manning's stress level, including switching him to a night shift with a lighter workload and suggesting he talk to a chaplain and keep a journal.
Manning, a 25-year-old native of Crescent, Okla., gave more than 700,000 documents and some battlefield video to WikiLeaks while working as an intelligence analyst in Iraq. He was convicted July 30 of 20 counts, including six federal Espionage Act violations, five theft counts, and a federal Computer Fraud and Abuse Act charge.
Manning says he leaked the material to expose wrongdoing and provoke discussion about U.S. military and diplomatic affairs.


text:
India vs South Africa 4th ODI 22nd October 2015 Match Schedule Live Score Board Team Squad: After long time, lots of match series between India vs South Africa will start from today .Now the 4th ODI match of series of One Day matches is being played today in India. The 4th ODI match between India vs South Africa is being played today i.e. October 22nd, 2015 at MA Chidambaram Stadium , Chennai at 01.30 pm (IST) onwards. Though India team had prepared well , and to win this series India will look for this match to win, for Indian team today's match is important and try to win series and on other side South Africa will try to win this series by winning today's match, already they have lead of 2-1 in ODI series. You can enjoy this one of the die interesting match between India vs South Africa , for more information scroll down.
Subuhi Joshi Unseen Leaked Photos
4th ODI 22nd October Match Details
|Match 4, ODI series
|Thurs, 22nd October, 2015
|India vs South Africa
|MA Chidambaram Stadium , Chennai
|01.30 pm IST
India vs South Africa 4th ODI Team Squad
South Africa (From): AB de Villiers, Quinton de Kock(w), Hashim Amla, Faf du Plessis(c), Jean-Paul Duminy, David Miller, Farhaan Behardien, Albie Morkel, Chris Morris, Kyle Abbott, Imran Tahir,Marchant de Lange, Eddie Leie, Kagiso Rabada, Khayelihle Zondo
India (From): Shikhar Dhawan, Rohit Sharma, Virat Kohli, MS Dhoni(w/c), Ajinkya Rahane, Suresh Raina, Stuart Binny, Ravichandran Ashwin, Harbhajan Singh, Bhuvneshwar Kumar, Mohit Sharma,Axar Patel, Sreenath Aravind, Ambati Rayudu, Amit Mishra
India vs South Africa Live Score Board 4th ODI Match 22nd Oct
All the fans of India and South Africa eagerly waiting to watch this interesting battle live telecast of 4th ODI match between India vs South Africa. Check out below for full information on live streaming of this match between India vs South Africa in India and other countries.
India vs South Africa live score
2) Ten Cricket
Now you can check live scores online by
Hope you enjoyed this post and gained information about India vs South Africa 4th ODI 22nd October 2015 Match Schedule Live Score Board Team Squad. For more details stay connected with us. Also, you can put your queries in Comment Box, we will respond quickly.


text:
Diversity in Franchising
The mission of the IFA Educational Foundation's Diversity Institute is to serve as a key catalyst for promoting and fostering diversity and inclusion within franchising, including franchisors, franchisees, suppliers and employees. The Diversity Institute realizes that the rapid pace of demographic changes and population growth combine to create unique opportunities for franchising. We believe that diversity and inclusion has the power to accelerate the mission of franchising.
Launched in February 2006, the MinorityFran program was developed to provide one convenient place where racial/ethnic minorities and women could explore franchise offerings of companies actively looking to recruit these emerging markets. This program was re-branded in July 2013 as DiversityFran.
DiversityFran is a franchisee education and recruitment program designed to assist IFA members in reaching emerging markets and increasing diversity while educating diverse prospective franchisees about opportunities in franchising.
DiversityFran builds on relationships forged with leading organizations such as the National Urban League, Minority Business Development Agency, U.S. Hispanic Chamber of Commerce, National Black MBA Association, Association of Small Business Development Centers, U.S. Conference of Mayors and various ethnic Chambers of Commerce across the country. We want to send a message that franchising is a model that works and is an affordable way to realize the American Dream of business ownership.
A study by the IFA Educational Foundation identified basic obstacles faced by minorities seeking to own a franchise and some challenges faced by franchisors seeking to recruit minorities as franchise owners. The three main obstacles were categorized as: (1) an informational gap, (2) a relational gap and (3) a capital gap. As a result of that study, in 2007 the Diversity Institute launched "One-Day Opportunities in Franchising for Women and Minorities" educational seminars across the country. These one-day seminars address all three gaps and include sessions on:
Franchising: A Business Model that Works (Fundamentals of Franchising): In this Franchising 101, participants receive an overview of franchising, have myths dispelled, learn how to evaluate a franchise and hear about special programs such as DiversityFran.
Experiences in Franchising: Panel of the Pros
Attendees hear from a panel of pros who have "been there and done that" or are looking to expand their franchise systems. Franchisees share their experiences and offer advice. Franchisors discuss what is expected from the franchisee and elaborate on the interview and selection process.
Legal Aspects of Franchising
Prospective franchisees learn about the Franchise Disclosure Document and what questions they need to ask before signing on the dotted line. They can also hear what steps they need to take to franchise a current business?
Finance and Technical Assistance
The ins and outs of franchising can be daunting. Once you have decided to move forward, where do you go for assistance? This session seeks to answer questions in layman's terms.
The DiversityFran program is open to all IFA member companies that are committed to expanding opportunities in franchising at all levels – in employment, in franchise recruitment and supplier relations.
When organizations embrace diversity and inclusion, it generates a positive return on their bottom lines. It is simply good business and an excellent growth strategy.
DiversityFran Participating Companies


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TOKYO -- Did the U.S. taxpayer save General Motors? Or was it really saved by the missteps and misfortunes of Japan's automakers?
An interesting line caught my attention in a recent article in the Nikkei newspaper, Japan's version of The Wall Street Journal and the official chronicle of Japan Inc.
It came from a story about how Japan's brands are turning on the heat in the United States to boost sales and market share.
The underlying implication was that for years Japan's brands had been fighting with one arm tied behind their backs. And the Nikkei pulled no punches when it came to GM:
"GM went bankrupt in June 2009 and went through a revival restructuring after that, but Toyota's recalls, Japan's earthquake, the strong yen and the Chinese boycott of Japanese products are mistakes and handicaps that also helped rescue it."
In other words, it wasn't just a pared brand lineup, plant closings, slashed labor costs and the cleansing benefit of bankruptcy that aided GM's turnaround.
Granted, this is just a sentence in a news analysis, not a quote from a Japanese auto executive or trade official. But the statement speaks to an underlying sense in Japan that GM got a free pass -- first by being bailed out and then by rebuilding itself while its Japanese rivals lay wounded on the sidelines.
The Nikkei article goes on to talk about how Japan is squaring off against stronger U.S. brands in North America and China.
But another main focus of the report is Detroit's opposition to a free-trade agreement with Japan. Japan's automakers are desperate for Japan to join the Trans-Pacific Partnership pact now under discussion.
Not surprisingly, the Detroit 3 say Japan should be held at bay until Tokyo eases market barriers to foreign brands in Japan.
And lately, they have denounced what they call currency manipulation by the Japanese government meant to spur exports.
The Nikkei's take on the Detroit 3's opposition: "They aim to protect tariff against Japanese cars."
What do you think about the newspaper's theories?


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Several techniques exist to create computer generated musical melodies. One of those techniques is genetic algorithms. Because the diversity of melodies over a specific range of notes is so large, genetic algorithms are a good candidate to help in composing melodies. This article describes how genetic algorithms can be used to compose musical melodies. this is explained following the steps needed to apply a genetic algorithm. These steps are:
- Define the genetical representation of the problem
- Determine the fitness function
- Determine the parameters used for the run
- Determine the termination criteria
For more information about using genetic algorithms in Java please see my previous article which can be found here: introduction to genetic algorithms. For more information about music theory which is applied in this article please refer to the excellent site http://www.musictheory.net.
Define the genetical representation
Before the genetic algorithm can do it's work, the genetical representation of the problem must be defined. To make things slightly less complicated the following constraints are introduced:
- Only harmonic melodies are supported. This means that only one note is played at ones at any given time in the melody.
- The generated melodies do not adhere to a specific measure. It is just a sequence of notes.
A Melody can be seen as a composition of individual notes and rests. Those individual notes have properties which define how a certain note must be played. The following properties are used which are modified by the genetic algorithm:
- Pitch
The pitch determines which notes on the grand staff is played. Possible values are C,D,E,F,G,A and B and all possible variants using sharps (#) and flats (b).
- Octave
The octave determines in which octave a certain note is played. A piano has seven full octaves.
- Duration
The length determines how long a certain note is played. Possible values are, whole notes, half notes, quarter notes, eight notes, sixteenth notes.
A solution in the search space of melody generation is a melody consisting of individual notes. A solution is represented as a chromosome with a fixed number of genes. The genes in the chromosome represent the individual notes and rests, each with it's own characteristics. A note can be represented by using a composite gene with three integer gene's. The three integer gene's represent pitch, octave and duration. Integer gene's are chosen in favor of a custom gene implementation to make mutation easy and simple across the individual gene's. Each gene is described in detail here:
Pitch: The pitch can be represented as a number from 1 to 12. Since there are twelve semitones in an octave, each semitone can be represented by a number from 1 to 12. Every following number is equal to one semitone. The mapping of the notes is:
C# or Db
D# or Eb
F# or Gb
G# or Ab
A# or Bb
Because all gene's are treated the same, a special case for the a rest in a melody is introduced. A rest has the value of 0 for the pitch. Since a rest is not associated with an octave, the octave property is ignored.
Octave: an octave can be represented by a number, the octave in which a certain note is played. The octave is indicated by a number from 1 to 7 where 1 represents the lowest octave on a piano keyboard and 7 the highest.
Duration: the duration can be represented by a number between 1 and 5. The mapping of the numbers are:
Whole note
Half note
Quarter note
Eighth note
Sixteenth note
The duration applies to both notes and rests. See the following code for the creation of the initial population of chromosomes:
Determine the fitness function
Configuration gaConf = new DefaultConfiguration();
gaConf.setFitnessEvaluator(new DeltaFitnessEvaluator());
CompositeGene gene = new CompositeGene(gaConf);
// Add the pitch gene
gene.addGene(new IntegerGene(gaConf, 0, 12), false);
// Add the octave gene
gene.addGene(new IntegerGene(gaConf, 1, 7), false);
// Add the length (from 3 - 5 is from quarter to sixteenth)
gene.addGene(new IntegerGene(gaConf, 1, 5), false);
// A size of 16 represent 16 notes
IChromosome sampleChromosome = new Chromosome(gaConf, gene, 16);
return Genotype.randomInitialGenotype(gaConf);
The fitness function determines how good a specific melody is, relative to other melodies. The fitness function is the most complicated part of this problem since the fitness of a melody is subjective. Because of this nature, two approaches for fitness determination are presented.
Computer generated fitness
The computer generated fitness is purely based on certain algorithms to measure the fitness of a melody. Since there are a lot of different parameters, the fitness function combines the fitness value of several different strategies which can be easily added to the fitness function. Some of these parameters, but not limited to, are:
- 80% of the notes in a melody may not have more than than 7 semitones difference.
- A melody may not span more than 2 octaves
- A melody must be in C-major (or minor scale)
- Only 10% of a melody may consist of rests
- Two consecutive notes may not lie more than 5 semitones from each other
- ...
- ScaleStrategy
Calculates if a given melody adheres to a specific scale, for example C major. The scale can be set as a parameter on this class.
- IntervalStrategy
Calculates if a given melody has one or more major and/or perfect intervals. The number of major and perfect intervals can be set as parameters on this class.
- GlobalPitchDistributionStrategy
Calculates if the lowest and highest pitch of a given melody fall within the margins specified by this class. The margin is indicated as the number of semitones and a percentage about how much of the notes must fall between the given semitones. These values can be set as parameters on this class.
- RepeatingNotesStrategy
Calculates if a given melody has repeating notes or rests. The maximum number of repeating notes and/or rests can be set as parameters on this class.
- PropertionRestAndNotesStrategy
Calculates the proportion between the notes and rests in a given melody. The propertion of notes/rests can be set as parameter on this class.
- ParallelIntervalStrategy
Calculates the number of parallel intervals in this melody. Some parallel intervals are supposed to sound good, like thirds and sixths. The number of good sounding parallel intervals can be set as a parameter on this class.
Please note that all rules calculate the deviation between the generated melody and the specified rules. A lower fitness value means less deviation which means a better melody. In the future it is planned to add more strategies to calculate the fitness of a given melody. For example:
- ContourStrategy. Strategy which calculates if a given melody has a specific contour in the pitch of the individual notes.
A different approach
public final class ScaleStrategy extends AbstractMelodyFitnessStrategy {
private static final int ERROR_COUNT_WHEN_NOTE_NOT_ON_SCALE = 1;
// The more difference between current note and note in scale the higher the error count
public double calculateErrors(IChromosome melody) {
double errors = 0.0D;
for (Gene gene : melody.getGenes()) {
Note note = GeneNoteFactory.fromGene((CompositeGene) gene);
if (Pitch.REST != note.getPitch() && !super.scale.contains(note.getPitch())) {
errors += ERROR_COUNT_WHEN_NOTE_NOT_ON_SCALE;
// Adhering to a given scale is quite important so square the result
return (errors * errors) * 10;
public String toString() {
return "[ScaleStrategy[scale: " + this.scale + "]]";
The above paragraph describes how the fitness of a melody can be computed based on the knowledge of music theory. Instead of using music theory to compute the fitness of a melody, a different approach can be used. This approach looks at the melody as audio data, an array of bytes, instead as a sequence of notes. From this audio data, different information can be extracted. For example, by using a Fast Fourier Transform (FFT), the audio data can be viewed in the frequency domain. By analyzing existing melodies using FFT, an algorithm can be constructed which measures the fitness of generated melodies based on this knowledge. A future version of the application may use the technique described here.
Human intervention based fitness
Since melodies are very subjective it is hard to come up with a computer based mechanism to measure how good a specific melody is. Another approach which can be used is a human based intervention fitness function. In this approach the user is represented with a fixed set of melodies generated by the genetic algorithm. The user selects two or three melodies which participate in the next evolution. Although this approach is not implemented in the current version, expect a future release to use this approach.
Determine the run parameters
When using a computer based fitness function, several parameters which affect the generated melody can be provided by the user. See the section about the computer generated fitness function which parameters can be supplied. Based on some sample runs, the number of evolutions to execute is 250. 250 evolutions seems like a good trade off between quality of the generated melody and computation time. The quality is measured in terms of the fitness value of the melody. With 250 evolutions, the fitness value of a 24-note melody almost always approaches zero.
Determine the termination criteria
The run ends when 250 evolutions are executed.
Some sample runs
The program can be executed in two different ways:
- By executing the MelodyGeneratorMain class file from the command line. Modify and recompile this class to alter the parameters of the run, for example the fitness function.
- Via the Swing UI. This is a very simple Swing UI build with Groovy's SwingBuilder. All of the parameters of the fitness function can be modified with this UI. Please note that this is a very simple UI implementation and not an example of how to write production quality Swing code.
This article explains how genetic algorithms can be used to compose melodies. Genetic algorithms seem like a viable alternative for melody generation since they are very well suited to search for specific solutions in very large search spaces. In this case the search space are all possible combination of notes. The difficulty in generating melodies with genetic algorithms is the specification of the fitness function since this is very subjective.
Although the melodies generated by this program are nowhere near hit melodies, they can be used as inspiration when composing melodies. The performance of the algorithm can be improved by writing additional (and more complex) strategies to measure the fitness of a melody.
Let me know what ideas you have to measure the fitness of the generated melodies to improve the quality of the melodies.
The full source code of this application can be found on Google code, see the resources.


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– Mick Foley, Sheamus, Rosa Mendes, Natalya and Stephanie McMahon were representing WWE at a USO event at the home of Vice Chairman of the Joint Chiefs of Staff Admiral Winnefeld yesterday. Here is a photo of them:
– Shawn Michaels noted on Twitter that he will be in attendance for NASCAR's NRA 500 race on April 13th from Texas Motor Speedway.
– Santino Marella is currently in Italy doing promotional work for WWE. He tweeted on Wednesday:
"What a great day in Roma! met with local students with the Be A Star program, had a signing, and heard the bells ring for the new pope!"


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Description:HP Proliant 8500 Quad Xeon 700MHz 2GB RAM MemoryPart Number(s)
Hewlett-Packard Part# 159378-001
Overview:Designed for maximum in-chassis flexibility that ensures lasting value and future growth Compaq ProLiant offers a full line of servers maximized for internal system expansion. Ideal for remote and branch office environments these servers offer headroom and scalability to easily accommodate new demands and growing environments. Today's mission-critical applications demand ever-increasing scalability and availability from data center servers. The new ProLiant 8500 the latest addition to Compaq's ultra-density data server product line delivers the performance and uptime required to meet the current and future demands of Enterprise server consolidation e-business ERP thin-client and data mining applications. Based on the Profusion architecture jointly developed by Compaq Corollary and Intel the ProLiant 8500 offers excellent scalability driven by its balanced system architecture.


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Of course, it could be that you always spend time looking for matching earrings for that particular dress, which is why you run late or you love wearing a particular dress for lazy lunches - and if you're anything like me that's a guaranteed recipe for splotches and stains!. And of course we took more road trips as a cozy couple and handed over the car to a driver when the kid came along!!
Inspite of all the rational explanations, these things seem to stick in our mind. The same thing happened with a lovely loaf tin my friend picked up for me when she saw a dealon while shopping. This was in June and immediately after that I somehow simply stopped baking! It had everything to do with the fact that I went back to full time work in July, but of course I blamed it on the poor loaf tin.
The best way to break that jinx? - bake something in it! So, I brought out my Sara Lewis book and saw this lovely Carrot & Mustard bread. I started quite late (around 7.30pm) and realised later it would only become colder as time wore on - definitely not ideal bread baking time. But I just can't seem to give up an idea once it takes hold, so I soldiered on. The yeast was fine and bubbled over, but when I kneaded the bread and left in a warm oven, it really didn't rise as much as it normally does. So I left it for almost an hour and 45 minutes before the second proofing. Kneaded it again and shaped the dough into three small buns and one oblong loaf.
30 minutes later it had not risen much at all and I was really sleepy and didn't think it was going to rise much anyway, so popped it into the oven to bake after glazing it. It baked quite beautifully and the glaze made it a nice golden top. But the inside of the bread, though cooked, was not the lovely spongy texture I look forward to....I guess, now that it's winter, I should stick to baking in the day when its a bit warmer. Or maybe it was the fact that I had used whole wheat flour instead of "granary flour" and plain flour instead of "strong white flour" and did not change the proportions. The flavours of the carrot and mustard were excellent though - definitely worth a second attempt.
Ah, well, atleast now the jinx has been broken and I can stop blaming the loaf tin........on the other hand, maybe I can blame the loaf tin for the bread!*evil grin*
This loaf of carrot bread specially to dear Cooker who is hosting this month's edition of JFI - where the ingredient is the Carrot. Jihva for Ingredients (JFI) is the brainchild of Indira and is probably one of the longest running Indian food blog events. Thank you Cooker for extending the last date!
Recipe adapted from Sara Lewis's The Bread Book
Wheat flour (atta) - 200gm (approx 2 1/4 cups)
Refined flour (maida) - 150gm (approx 1 3/4 cups)
Water - 200ml (1 cup)
Dried active yeast - 3 tsp
Sugar - 1 tsp
Honey - 1 tsp
Mustard - 2 tbsp
Carrots - grated, 1 cup
Salt - 1 tsp
Butter - 2 tbsp
Egg yolk - 1
1. Warm up the water, dissolve the sugar in it and when lukewarm add the yeast to it. Keep aside for about 15 minutes till it bubbles and froths.
2. In a large mixing bowl, mix the flours with the butter, rubbing till it resembles breadcrumbs.
3. Add the salt, honey, mustard, grated carrot and the yeast mixture and knead for 10 minutes to a smooth dough.
4. Cover with an oiled clingwrap and set aside in a warm place for about an hour or till it doubles in size.
5. Knead again and shape into an oblong loaf or form into a thick rope and twist from one side like a corkscrew.
6. Put into a greased loaf tin (I used a 1 litre loaf tin for the loaf and made the rest of the dough into three small rolls) and set aside for another 30 minutes till it rises to the top (depending on the height of the tin).
7. Pre heat the oven to 200C, brush the egg yolk mixed with 1 tbsp water on to the top of the loaf and then bake for about 30-35 minutes. If the top is browning too much after the first 15 minutes, cover with foil and continue baking.
8. Remove from oven, the bread should sound hollow when tapped. Remove from tin carefully and keep on wire rack to cool.


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Mark99 needed a new logo design and created a contest on 99designs.
A winner was selected from 179 designs submitted by 59 freelance designers.
Groupola / Groupola.com
we are launching a new group buying website, similar to groupon.com, buywithme.com The website will feature a different deal every day customized to the users location e.g city. We want to have a theme of family, friends and work colleagues as the basis of the website is getting people involved to spread the word about the daily deals, referring friends and family to the website using online social sites, email and twitter etc. The more people that buy, the cheaper the deal. We want to have characters featured on the website – friendly, warm and smooth edged. We were also thinking about utilizing a bug theme (groups) – for instance ants (like letsbuyit.com) or aliens etc. We are totally open to any ideas you may have. We essentially want to portray happy users saving money and being social through using our service. We also need to capture the image of friends bringing on friends – spreading the word!
Men and women aged 22 – 45 that are looking for local deals and discounts. They are excited about using the deals.
Should show social, that people are spreading the word about the deals listed and getting their friends to buy the deal also.
Descriptive words: funky style, modern, fun, trustworthy
The brand must appeal to both men and women.
It should not be over the top, it needs a good balance between being fun and professional.
Keep the same colour for the font throughout - want to keep 'Groupola' as one word, rather than people reading it as two.
Find out how a design contest works or learn more about our logo design services.


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Parents of missing Lauren Spierer mark daughter's birthday, make plea for help
The parents of an Indiana University student missing for more than 18 months are marking their daughter's 22nd birthday with a nationwide plea for information that might help them find her.
Lauren Spierer went missing about 4:30 a.m. June 3 after a night of partying with friends in downtown Bloomington.
WRTV-TV reports Robert and Charlene Spierer of Greenburgh, N.Y., said on their website Thursday that they understand their daughter is likely dead even though no remains have been found and no arrests have been made. But they stressed that they are determined to find out what happened to her.
Anyone with information about Spierer's case is asked to call the Bloomington Police Department.


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So Proud of My Dad
CGA Ontario published in May's "Statement Magazine" the list of those that qualified as LPA's this year. This is a new thing for CGA Ontario (2nd year) and my dad studied his face off to get it.
It was a massive accomplishment for our firm, and a huge accomplishment for him personally!
Way to go Dad!


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A fire in a nightclub killed at least 245 people in southern Brazil, yesterday, when a band's pyrotechnics show set the building ablaze and fleeing patrons were unable to find the emergency exits in the ensuing panic, officials said.
According to the Associated Press (AP) news, the blaze in the southern city of Santa Maria was started when a band member or someone from its production team ignited a flare, which then set fire to the ceiling, said Luiza Sousa, a civil police official. The fire spread "in seconds," she said.
An estimated 500 people were in the Boate Kiss nightclub when the fire broke out early on Sunday, and many were unable to find the exits as dark smoke quickly filled the room. At least one exit was locked, trapping hundreds inside to die, many from asphyxiation as they inhaled smoke, police said.
"When I looked around, all I saw were dead bodies lying on the floor. It was macabre," survivor Taynne Vendrusculo told GloboNews TV. "It all happened so fast. Both the panic and the fire spread rapidly in seconds."
Television footage showed people sobbing outside the club, while shirtless firefighters used sledge hammers and axes to knock down an exterior wall to open up an exit. By noon (1400 GMT), the death toll had risen to 245 and 48 people were being treated in local hospitals, said Major Cleberson Bastianello, head of the military police unit leading the rescue efforts. He said all of the bodies of the victims had been removed from the nightclub.
President Dilma Rousseff, who started her political career in the same state where the fire happened, cut short a visit to Chile to return to Brazil to visit the scene. Before departing, Rousseff gave a televised statement in which she broke down in tears as she pledged government help for the victims and their families.
"We are trying to mobilise all possible resources to help in the rescue efforts," she said. "All I can say at the moment is that my feelings are of deep sorrow." The disaster recalls other incidents including a 2003 fire at a nightclub in West Warwick, Rhode Island, that killed 100, and a Buenos Aires nightclub blaze in 2004 that killed nearly 200. In both incidents, a band or members of the audience ignited fires that set the establishment ablaze.
Brazil's safety standards and emergency response capabilities are under particular scrutiny as it prepares to host the 2014 World Cup soccer tournament and the 2016 Olympics. The Boate Kiss nightclub was a popular venue in Santa Maria, a university town of more than 275,000 people. The massive nightclub sometimes attracts up to 2,000 people on a given night, according to reviews on the Internet.
One of the club's owners had already surrendered to police in Santa Maria for questioning, GloboNews reported. Rio Grande do Sul state Health Secretary Ciro Simoni said emergency medical supplies from all over the state were being sent to the scene.
Santa Maria is some 186 miles west of the state capital of Porto Alegre. "A sad Sunday!" tweeted Rio Grande do Sul Governor Tarso Genro. He said "all possible measures" were being taken in response.
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Surj needed a new logo design and created a contest on 99designs.
A winner was selected from 196 designs submitted by 76 freelance designers.
We are looking for a logo for our product's website.
Our product is called Click eClock, it is an online timesheet application.
Our Customers are small to medium businesses and individuals
Click eClock
The competition is to design a logo forClick eClock. It would be good if the logo has reference to a clock or to time - the prototype website features a real-time clock.
The name "Click eClock" should also feature.
The logo should work in print and in black &white, as it will be used for letterheads and businesscards, as well as the website.
The final files need to be supplied in vector format, ideally SVG, but any modern vector format will do.
Lastly, we welcome bold, original entries that are eye-catching and memorable.
- Innovative, modern and memorable design
- A reference to time or a clock
- Our company name "Click eClock"
- We welcome bold, original entries that are eye-catching and memorable.
- No mice (computer mice)
- No actions of mice clicking a clock :-)
Find out how a design contest works or learn more about our logo design services.


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Dani coaches, consults, and mentors people from all walks of life, from multi-millionaire executives to people struggling to just get by, in personal achievement, career advancement, conflict resolution, business growth, leadership development, teamwork, confidence building, overcoming fear, spiritual issues, parenting and grooming kids for success, marketing solutions, executive decision making, profit strategies , relationship marketing, time management, debt elimination, and wealth attainment. All that matters is that the person is teachable, hungry with desire, and willing to learn As Dani says, "I'll equip you to succeed beyond your wildest dreams… if you let me." Dani's proven strategies equip her clients with the skill sets that land them the best jobs, get the biggest raises, grow companies in a down economy, raise success minded children, and so much more. Thousands have traveled from all parts of the world to attend her live training seminars. Men and women from ages 7 to 101, every race, religion, economical status, educated, uneducated, experts beginners and everything in between gather to learn from this dynamic, thought provoking speaker who produces results with her clients. Dani has been seen on TV by millions of viewers the world over through her numerous appearances onworldwide television netwrks including CNBC, TBN, Daystar and PAX.Dani is passionately dedicated to her husband Hans, 5 kids and 2 grandchildren. She and her husband Hans are the founders of King's Ransom Foundation, a non-profit charity dedicated to serving people in need, especially families and children, worldwide.
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text: "The war between the States," which a good many Southerners prefer, is both bookish and inexact. "Civil war" is an utter misnomer. It was used and is still used by courteous people, the same people who are careful to say "Federal" and "Confederate." "War of the rebellion," which begs the very question at issue, has become the official designation of the struggle, but has found no acceptance with the vanquished. To this day no Southerner uses it except by way of quotation .... "The war of secession" is still used a good deal in foreign books, but it has no popular hold. "The war," without any further qualification, served the turn of Thucydides and Aristophanes for the Peloponnesian war. It will serve ours, let it be hoped, for some time to come. [Basil L. Gildersleeve, "The Creed of the Old South," 1915]