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Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01527045
Recruitment Status : Recruiting
First Posted : February 6, 2012
Last Update Posted : November 28, 2018
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Aggressive Non-Hodgkin Lymphoma Blasts Under 5 Percent of Bone Marrow Nucleated Cells Chronic Lymphocytic Leukemia Loss of Chromosome 17p Myelodysplastic/Myeloproliferative Neoplasm Non-Hodgkin Lymphoma Prolymphocytic Leukemia Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Recurrent Aggressive Adult Non-Hodgkin Lymphoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Recurrent Chronic Lymphocytic Leukemia Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive Recurrent Diffuse Large B-Cell Lymphoma Recurrent Hodgkin Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Non-Hodgkin Lymphoma Recurrent Plasma Cell Myeloma Recurrent Small Lymphocytic Lymphoma Waldenstrom Macroglobulinemia
|Drug: Atorvastatin Calcium Drug: Cyclosporine Drug: Fludarabine Phosphate Other: Laboratory Biomarker Analysis Drug: Mycophenolate Mofetil Procedure: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation Procedure: Peripheral Blood Stem Cell Transplantation Radiation: Total-Body Irradiation
|Phase 2
I. To assess whether 2 weeks of donor statin treatment reduces the risk of severe acute GVHD.
I. To assess whether 2 weeks of statin treatment of normal PBSC donors is feasible, tolerable and safe.
DONOR: Donors receive atorvastatin orally (PO) once daily (QD) beginning on day -14 and continuing until the last day of stem cell collection.
NONMYELOABLATIVE PREPARATIVE REGIMEN: If the patient is enrolled on an investigational nonmyeloablative hematopoietic cell transplant (HCT) protocol or a treatment plan that uses a nonmyeloablative preparative regimen with postgrafting cyclosporine (CSP) that does not use acute GVHD as its primary endpoint, the preparative regimen and immunosuppression after transplant will be according to respective protocol or treatment plan (Protocol 2546 serves as adjunct protocol).
If the patient is not enrolled on an investigational nonmyeloablative HCT protocol or a treatment plan that uses a nonmyeloablative preparative regimen, Protocol 2546 serves as an independent primary treatment protocol. The preparative regimen and immunosuppression after transplant is as follows:
Patients receive fludarabine phosphate intravenously (IV) on days -4 to -2 (except for patients who had prior autologous HCT or equivalent high-dose therapy without HCT) and undergo low-dose total body irradiation (TBI) on day 0.
TRANSPLANT: Patients undergo donor PBSC transplant on day 0.
POST-GRAFTING IMMUNOSUPPRESSION: Patients receive CSP PO twice daily (BID) on days -3 to 56 with taper to day 180. Patients also receive mycophenolate mofetil (MMF) PO BID or IV every 12 hours on days 0-27.
After completion of study treatment, patients are followed up at 1 year and then annually thereafter.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|100 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Donor Statin Treatment for Prevention of Severe Acute GVHD After Nonmyeloablative Hematopoietic Cell Transplantation
|Actual Study Start Date :
|September 25, 2012
|Actual Primary Completion Date :
|October 26, 2018
Experimental: Prevention (donor statin treatment)
See Detailed Description
Drug: Atorvastatin Calcium
Given PO
Other Names:
Drug: Cyclosporine
Given PO
Other Names:
Drug: Fludarabine Phosphate
Given IV
Other Names:
Other: Laboratory Biomarker Analysis
Correlative studies
Drug: Mycophenolate Mofetil
Given PO or IV
Other Names:
Procedure: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation
Undergo nonmyeloablative allogeneic PBSC transplant
Other Names:
Procedure: Peripheral Blood Stem Cell Transplantation
Undergo nonmyeloablative allogeneic PBSC transplant
Other Names:
Radiation: Total-Body Irradiation
Undergo TBI
Other Names:
- Proportion of patients who develop grade 3-4 acute graft-versus-host disease (GVHD) after transplant [ Time Frame: Up to day 100 ]The cumulative incidence of this endpoint in patients prepared with nonmyeloablative conditioning regimens after hematopoietic cell transplant (HCT) from human leukocyte antigen (HLA)-matched related donors, and with cyclosporine (CSP)-based immunosuppression is approximately 9%. A reduction in the cumulative incidence of acute GVHD from 9% to < 2% would represent a reasonable goal after nonmyeloablative HCT and constitute study success.
- Chronic extensive GVHD [ Time Frame: Up to day 100 ]Assessed with the use of cumulative incidence plots. Patients will be evaluated for chronic GVHD as described in the National Institutes of Health (NIH) consensus project guidelines. Graft failure, recurrent malignancy and death without GVHD are considered to be competing risks for GVHD.
- Disease-free survival [ Time Frame: At 1 year after transplant ]Evaluated as Kaplan-Meier estimates.
- Grades II-IV acute GVHD [ Time Frame: Up to day 100 ]Assessed with the use of cumulative incidence plots.
- Non-relapse mortality [ Time Frame: Up to 1 year ]Defined as death in the absence of recurrent or progressive malignancy after HCT. Assessed with the use of cumulative incidence plots.
- Overall survival [ Time Frame: At 1 year after transplant ]Evaluated as Kaplan-Meier estimates.
- Proportion of donors who have to discontinue atorvastatin because of toxicity [ Time Frame: Prior to stem cell collection ]The number of donors who prematurely discontinue atorvastatin therapy and the reasons for discontinuation will be described.
- Proportion of patients requiring secondary systemic immunosuppressive therapy [ Time Frame: Up to 4 years ]Assessed with the use of cumulative incidence plots. The need for primary and secondary systemic immunosuppressive treatment with agents other than those used for prophylaxis and initial therapy, the reason for their administration (acute GVHD, chronic GVHD, or other reasons) will be determined.
- Recurrent or progressive malignancy [ Time Frame: Up to 4 years ]Assessed with the use of cumulative incidence plots. Recurrent malignancy will be defined by hematologic criteria. Recurrent malignancy will also be defined as any unplanned medical intervention designed to prevent progression of malignant disease in patients who have molecular, cytogenetic or flow-cytometric evidence of malignant cells after transplantation.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|Child, Adult, Older Adult
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Availability of human leukocyte antigen (HLA)-identical sibling donor
- Transplantation with PBSC
- CSP-based postgrafting immunosuppression
- Willingness to give informed consent
- Patient is enrolled on an investigational nonmyeloablative HCT protocol or a nonmyeloablative treatment plan with postgrafting CSP that does not use acute GVHD as its primary endpoint (protocol 2546 serves as adjunct protocol); OR
- Patient is not enrolled on an investigational nonmyeloablative HCT protocol, in which case protocol 2546 serves as an independent primary treatment protocol and the patient must meet the following inclusion and exclusion criteria:
- Patients must have a hematologic malignancy treatable by nonmyeloablative HCT; the following diseases will be permitted although other diagnoses can be considered if approved by Patient Care Conference (PCC) and the principal investigator:
- Aggressive non-Hodgkin lymphomas (NHL) and other histologies such as diffuse large B-cell NHL - not eligible for autologous HCT, not eligible for high-dose allogeneic HCT, or after failed autologous HCT
- Mantle-cell NHL - may be treated in first complete remission (CR); (diagnostic lumbar puncture [LP] required pre-transplant)
- Low grade NHL - with < 6 month duration of CR between courses of conventional therapy
Chronic lymphocytic leukemia (CLL) - must have either:
- Failed to meet National Cancer Institute (NCI) Working Group criteria for complete or partial response after therapy with a regimen containing fludarabine phosphate (FLU) (or another nucleoside analog) or experience disease relapse within 12 months after completing therapy with a regimen containing FLU (or another nucleoside analog)
- Failed FLU-cyclophosphamide (CY)-Rituximab (FCR) combination chemotherapy at any time point; or
- Have "17p deletion" cytogenetic abnormality; patients should have received induction chemotherapy but could be transplanted in 1st CR
- Patients with a diagnosis of CLL (or small lymphocytic lymphoma) that progresses to prolymphocytic leukemia (PLL); or
- Patients with T-cell CLL or PLL
- Hodgkin lymphoma - must have received and failed frontline therapy
- Multiple myeloma - must have received prior chemotherapy; consolidation of chemotherapy by autografting prior to nonmyeloablative HCT is permitted
- Acute myeloid leukemia (AML) - must have < 5% marrow blasts at the time of transplant
- Acute lymphocytic leukemia (ALL) - must have < 5% marrow blasts at the time of transplant
- Chronic myeloid leukemia (CML) - Patients will be accepted if they have shown intolerance to tyrosine kinase inhibitors or are beyond first chronic phase (CP1) and if they have received previous myelosuppressive chemotherapy or HCT, and have < 5% marrow blasts at time of transplant
- Myelodysplasia (MDS)/myeloproliferative syndrome (MPS) - Patients must have < 5% marrow blasts at time of transplant
- Waldenstrom's macroglobulinemia - must have failed 2 courses of therapy
- Patients < 12 years of age must be approved by the principal investigator and by a relevant patient review committee, such as the Fred Hutchinson Cancer Research Center (FHCRC) Patient Care Conference (PCC)
- Patients must have either relapsed after previous high-dose chemotherapy and autologous or allogeneic HCT, or else be ineligible for such an approach due to age, failure to mobilize sufficient hematopoietic stem cells, medical comorbidities, or patient refusal
- Patients who refuse to be treated on a conventional autologous or allogeneic HCT protocol
- DONOR: Age >= 18 years
- DONOR: HLA genotypically identical sibling
- DONOR: Willingness to give informed consent
Exclusion Criteria:
- Myeloablative preparative regimen
- Participation in an investigational study that has acute GVHD as the primary endpoint
- The allogeneic PBSC donor has a contraindication to statin treatment
- Patients eligible for and willing to receive potentially curative high-dose chemotherapy and autologous HCT
- Cardiac ejection fraction < 30% on multi gated acquisition scan (MUGA) scan or cardiac echocardiogram (echo) or active symptomatic coronary artery disease; patients with cardiac disease should be evaluated with appropriate cardiac studies and/or cardiology consultation as clinically indicated
- Corrected diffusion capacity of the lung for carbon monoxide (DLCO) < 40% of predicted, total lung capacity (TLC) < 30% of predicted, forced expiratory volume in one second (FEV1) < 30% of predicted, or receiving continuous supplementary oxygen
- Patients with clinical or laboratory evidence of liver disease should be evaluated in conjunction with the gastrointestinal (GI) consult service for the cause of the liver disease, its clinical severity, and the degree of portal hypertension; patients will be excluded if they are found to have fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, bridging fibrosis, alcoholic hepatitis, esophageal varices, a history of bleeding esophageal varices, hepatic encephalopathy, refractory ascites related to portal hypertension, bacterial or fungal liver abscess, chronic viral hepatitis with total serum bilirubin > 3mg/dl, or actively symptomatic biliary disease
- Patients with renal failure are eligible; however, patients with pre-existing renal insufficiency will likely have further compromise in renal function and may require dialysis
- Patients who are seropositive for human immunodeficiency virus (HIV)
- Women who are pregnant or breast-feeding
- Fertile men or women unwilling to use contraception during HCT and for 12 months afterward
- Patients with active non-hematological malignancies (except non-melanoma skin cancers) or those with non-hematological malignancies (except non-melanoma skin cancers) who have been rendered with no evidence of disease, but have a greater than 20% chance of having disease recurrence within 5 years; this exclusion does not apply to patients with non-hematologic malignancies that do not require therapy
- Karnofsky score < 60 for adult patients
- Lansky-play performance score < 50 for pediatric patients
- Patients with fungal pneumonia with radiological progression after receipt of amphotericin formulation or mold-active azoles for greater than 1 month
- DONOR: Age < 18 years
- DONOR: History of liver disease; a donor with a history of liver disease would be eligible if the serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) are < 2 times upper limit of normal (ULN)
- DONOR: History of myopathy
- DONOR: Hypersensitivity to atorvastatin
- DONOR: Pregnancy
- DONOR: Nursing mother
- DONOR: Current serious systemic illness
- DONOR: Concurrent treatment with strong inhibitors of hepatic CYP 3A4 (i.e. clarithromycin, erythromycin, protease inhibitors, azole antifungals)
- DONOR: Failure to meet local criteria for stem cell donation
- DONOR: Total creatinine kinase > 2 times the ULN
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01527045
|United States, Colorado
|Presbyterian - Saint Lukes Medical Center - Health One
|Denver, Colorado, United States, 80218
|United States, Washington
|Fred Hutch/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Contact: Marco Mielcarek 206-667-2827 firstname.lastname@example.com
|Principal Investigator: Marco Mielcarek
|Principal Investigator:
|Marco Mielcarek
|Fred Hutch/University of Washington Cancer Consortium
|Responsible Party:
|Fred Hutchinson Cancer Research Center
|ClinicalTrials.gov Identifier:
|NCT01527045 History of Changes
|Other Study ID Numbers:
NCI-2011-03828 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
2546.00 ( Other Identifier: Fred Hutch/University of Washington Cancer Consortium )
P01CA018029 ( U.S. NIH Grant/Contract )
P30CA015704 ( U.S. NIH Grant/Contract )
|First Posted:
|February 6, 2012 Key Record Dates
|Last Update Posted:
|November 28, 2018
|Last Verified:
|November 2018
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Additional relevant MeSH terms:
Waldenstrom Macroglobulinemia
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Lymphoma, Non-Hodgkin
Leukemia, Lymphoid
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma, B-Cell
Hodgkin Disease
Lymphoma, Mantle-Cell
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoma, Large B-Cell, Diffuse
Myeloproliferative Disorders
Multiple Myeloma
Neoplasms, Plasma Cell
Myelodysplastic-Myeloproliferative Diseases
Leukemia, Prolymphocytic
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell
Bone Marrow Diseases
Hematologic Diseases
Behavioral Symptoms


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*Limited Edition* Regatta / Silk Twine
*Limited Edition* Regatta / Silk Twine
Our richest shade of dark navy.
Our ribbons are made of a light silk habotai and dyed in small batches from a unique blend of pigments to create subtle and complex shades. They're then hand torn, frayed and spooled for an organic, soft feel. The silk twine is our narrowest ribbon, approx. 1/8 - 1/4" at it's widest point. It hasn't been steamed and has a few loose threads here and there so it has a lovely organic feel to it and looks beautiful wrapped around stationery once or even twice. Each spool contains 12 yards.
Due to the handmade nature of our ribbons please allow 5 business days for production. For rush orders please email firstname.lastname@example.com

subset: commoncrawl


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Three Chucks selected for Lezzer Lumber Football Classic
PUNXSUTAWNEY — Most graduating seniors played their final football game as a representative of the Chucks last November, but three of those now-graduated seniors have been chosen to represent Punxsutawney in the 27th-annual Lezzer Lumber Football Classic, which will take place at 7 p.m. Friday at Bald Eagle Area Alumni Field in Wingate.
Punxsutawney offensive/defensive lineman Devon Luzell, who will play college football for Mercyhurst College in the fall, will be joined by wide receiver/defensive back Zak Dickey in the Classic. Ben Blazavich, who played a variety of positions for the Chucks last year on both sides of the ball, was also selected, but is unable to play due to another commitment.
Luzell and Dickey will join several other players, many of whom they were matched up against as rivals this past year, to form the North team, which is seeking its third straight victory in the Classic.
"I was able to talk to both of the young men yesterday, and they're really excited about the chance to put the pads back on," Punxsy head football coach Alan Nichol said Wednesday. "I know they're both leaders, and among a bunch of other guys who are All-Stars, it makes me feel a lot of pride for what they're accomplishing for our town, in representing Punxsy."
Luzell, an all-conference selection on both sides of the ball, will play guard in the Classic. He may see some time on the defensive side, as well.
"Devon is very aggressive, and he loves the game," Nichol said. "He'll show a great deal of concentration, which is what you need to do in an All-Star game, because you have such a short time to prepare."
Nichol also pointed out that Luzell would be eager to suit up for any football action, saying that, "Devon would be ready to play on Christmas morning if you called him."
Dickey will be playing cornerback in the All-Star game, a position where he has displayed great skill for the Chucks. He had three interceptions for Punxsy last year.
Dickey, who had impressive numbers both offensively and defensively, also shined in special teams by returning kickoffs and punts. Dickey averaged 16 yards per punt return and 32.75 yards per kick return during the 2010-11 season.
"We're hoping that he gets a chance to return some punts, because he did a fantastic job for us there this season, as well," Nichol said about Dickey. "Zak's looking forward to the game, and he'll do very well because of his quickness."
With the former Chucks participating in the Lezzer Lumber Classic, the community receives a bit of a reminder that football season is not as far away as it may seem. In just a few short months, the Chucks will be starting two-a-days, and for fans, the season will be starting before they know it.
"The community has shown great support for these guys," Nichol said referring to Luzell, Dickey and Blazavich. "I appreciate the members of the community being so supportive."
The Classic will be Dickey's last opportunity to suit up, as he does not plan to play college football, making this game the final opportunity for fans to see him play. Luzell will be back in the midst of two-a-days himself soon, when the Mercyhurst Lakers begin their football camp this summer.


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Despite advances, not all liver tumors can be removed completely by surgery. Some tumors are simply too large or widespread throughout the liver, or have recurred after prior surgery. Some patients have other health conditions that may preclude them from undergoing liver surgery. For inoperable tumors, ablation therapies can be a beneficial alternative, and provide a curative option, extend survival and improve quality of life.
With ablation therapies, a surgeon or an interventional radiologist inserts a probe directly into the tumor or tumors, using guidance from ultrasound or CT imaging. The probes generate heat above water's boiling point (100°C) which kills the cancer cells. The probes use various energy sources such as radio waves, microwaves, or electricity and may be directed to the tumor through the skin (percutaneous) or through tiny incisions (laparoscopic). Roswell Park offers these outpatient ablation therapies for liver tumors:
- Radiofrequency ablation (RFA): A probe inserted into the tumor springs to emit radio waves around the tumor, heating and destroying cancer cells.
- Microwave (MW) ablation: Uses microwaves to heat and destroy the cancer cells.
- NanoKnife irreversible electroporation, or NanoKnife IRE: This newest ablation technology destroys tumor cells using high-voltage electrical energy. With NanoKnife, multiple probes shoot electricity between them, poking microscopic holes in the cells, enhancing cancer cell death while protecting critical blood vessels.


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Traveller Tips
Can I smoke on board the Venice Simplon-Orient-Express train?
No. To comply with Italian and other European regulations, Venice Simplon-Orient-Express train operates a no smoking policy on board both the Belmond British Pullman and the continental train.
What do I wear on the Venice Simplon-Orient-Express train?
You can never be overdressed on the Venice Simplon-Orient-Express train. For dinner, we ask that men wear a suit and tie and women dress in smart attire, but many guests like to don black tie or evening dress for the occasion. During the day the dress code is smart-casual. At lunch, for example, a jacket and tie is suitable for men. Jeans are not acceptable at any time.
What languages do staff on board the train speak?
French, English and Italian are spoken by most stewards on board the continental train.
What to Wear
For daytime excursions and relaxing on board, we suggest casual, comfortable attire. In the evening, we recommend a jacket and tie for dinner.
What currency do I need on board the Venice Simplon-Orient-Express train?
Prices are quoted in Euros and it is recommended that passengers have a small number of Euros for onboard purchases. However, most major currencies are accepted, as well as travellers' cheques, Eurocheques and major credit cards (Visa, Mastercard, American Express, Diners Club and JCB). The exchange rate on board is displayed in the Bar Car.
How long does my journey take?
Journeys on the Venice Simplon-Orient-Express train can last from one to several days. The traditional and most popular route between London and Venice takes two days, with one night on board. See Journey Search for details of our other departures.
How do I cross the English Channel?
Passengers travelling from or to London will board the Belmond British Pullman carriages of the Venice Simplon-Orient-Express train between London and Folkestone. You are then escorted by our hostess to a luxury coach for the Channel crossing on the Eurotunnel shuttle.
Will I need insurance for my trip?
As with all holidays and trips abroad, it is advisable to have travel insurance. Your Belmond Reservations Office will be able to advise you.
Will there be room in my compartment for all my luggage?
Despite having luggage racks in our cabins, space constraints require that luggage is limited, per passenger, to: one suitable piece of hand luggage, one suit carrier or overnight bag (to be placed in your cabin), and one suitcase to be stored in the baggage car, where it will not be accessible until you reach your destination.
Will I need to tip the Venice Simplon-Orient-Express staff?
Any gratuities you wish to give are entirely at your discretion.Additional travel information


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Pluckley CofE Primary School Pluckley, Kent
Pluckley CofE Primary School
* marker is placed on the street of the school
Education News
- Will universities go bust if fees are cut?
- Labour pledges to prevent universities from going bust
- 'Lessons to be learnt' over older Stoke High School pupil
- Peterborough University delay 'a kick in the teeth'
- Climate strike: Schoolchildren protest over climate change
- Black pupils' schooling 'dumbed down over special needs'
- Half of universities have fewer than 5% poor white students
- The self-taught pianist drawing crowds
- Climate march students: 'We need change and we need it now'
- Perinatal OCD: 'I was worried I'd do something to my kids'
- The robot helping a seven-year-old boy go to school
- Glasses in school scheme to aid pupils' reading
- The mother who lost her daughter over an EpiPen
- Climate strike: Why are students striking and will it have an impact?
- Unconditional uni offers don't make us lazy, say teenagers
Sport News
- Chelsea 0-2 Man Utd: Ander Herrera and Paul Pogba give visitors victory
- Formula 1 testing 2019: Williams in turmoil as Sebastian Vettel fastest
- Laureus World Sports Awards: Simone Biles and Novak Djokovic win top honours
- Jurgen Klopp: Crowd can take Liverpool 'from 100% to 140%'
- FA Cup quarter-final draw: Man Utd face Wolves in last eight
- Tyson Fury signs ESPN fight deal worth reported Ł80m
- Caster Semenya: South African runner's appeal against IAAF rule begins
- Toto Wolff: Mercedes boss has concerns about impact of Brexit on F1
- Manchester United: Saudi Arabia prince Mohammed Bin Salman denies takeover bid
- Daytona 500: Crash damages 18 cars as Denny Hamlin wins Nascar showpiece
- NBA All-Star: Giannis scores game-high 38 points in defeat to Team LeBron
- Nasir Jamshed denies Pakistan cricket bribery
- Liverpool: Would Jurgen Klopp rather win Premier League or Champions League?
- Snow, mild panic attacks & tea: Why is this Burnley fan RUNNING to every away Premier League game?
- Tottenham 3-0 Dortmund: Mauricio Pochettino says his players are heroes


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As promised, we will continue to offer a running list of deals every weekend through Christmas. This list is prepared by the Daily Press Savvy Shopper and bargain hunters from crazytowndeals.com.
This list of deals is valid from Friday, Dec. 13 to Sunday, Dec. 15.
Here is some news to get you started:
Walmart will begin a price-drop event at 8 a.m. Friday, Dec. 13.
Deals include:


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Mayor Don Wesely will attend this evening's Hawley Area Neighborhood Association cookout, an event planned for the "National Night Out Against Crime." The cookout begins at 6 p.m. at McWilliams Park, 25th and "T" streets.
"One of the reasons we enjoy a safe city is neighborhood involvement and the willingness of citizens to support anti-crime efforts," said Wesely. "National Night Out has become the nation's largest crime prevention event, and I encourage all citizens to take part in this 18th annual observance. Together, we can send law breakers the message that we support our law enforcement officers, and we do take a strong stand against crime in our city."
From 6 to 10 p.m. tonight, citizens are asked to lock their doors, turn on outside lights and spend the evening outside with their neighbors. Police officers will also be visiting neighborhood events. National Night Out is sponsored by the National Association of Town Watch and co-sponsored by the local Neighborhood Watch Program.
Media Release


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Doggy UFO
Adventure Games Speldome 13 Apr , 2012 0
Adventure Games Speldome 13 Apr , 2012 0
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Finding the right drug and alcohol addiction treatment center can be difficult if you don't know what you're looking for. It's important to understand what services such treatment centers provide and if they will accommodate your needs. The best drug and alcohol addiction treatment centers provide treatment services that are implemented based specifically on the needs of the patient. Not many people know this, which is why we are here to help.
DrugRehabAdvisors will help you find the perfect treatment center to suit all of your needs so that you can effectively recover from your addiction. We will match your needs to the best drug and alcohol addiction treatment facilities in Bedford, Ohio. You deserve only the very best treatment for your addiction, and we firmly believe in finding the most innovative treatment centers for you.
Below is a list of top 10 drug and alcohol addiction rehab facilities in Bedford, Ohio that offers top-of-the-line compassionate care and support to their patients. These treatment centers have some of the most qualified, experienced, and dedicated staff of addiction specialists that will help to guide you towards lifelong sobriety. They create treatment plans that are customized to suit the specific needs of the patient to ensure that they receive the most effective treatment possible. There is the perfect addiction treatment center out there for you and we at DrugRehabAdvisors are here to help you find it.
Astara House is a Substance Abuse Center in Bedford, OH.


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Some days back, I was off to the Refuge to note how things have changed over the past several weeks. It is not yet dawn. I take loop road. Fields and uplands come awake. Little birds are in an impromptu chorus led by tiny wrens with uplifted tail feathers and loud crisp songs, notes grouped in two, three, four, and more, "Cedar, Cedar, Cedar Key," "Veeger, veeger, veeger, veeger, veeger."
Remember how simple it used to be to go on a vacation or any other trip? All you had to do was throw some clothes and toilet articles into a suitcase, throw the suitcase into the car and off you go. Now we have so many other necessities to take along, it is such a major undertaking that you have to start packing days ahead of time.
When I was a child I was curious about the mysteries of our planet. I still am to this day.
Soon I will be going to the Hawaiian Islands and have been doing a little research in preparation. This will be especially helpful when I fly above, but low over them in a small airplane. I have reserved a Cessna like mine for when I arrive.
The beginnings of the Hawaiian island chain are intriguing. They started in one of the most remote places on earth from the movement of tectonic plates deep below the Pacific Ocean over 70 million years ago.
"Fathers, do not exasperate your children; instead, bring them up in the training and instruction of the Lord." (Ephesians 6:4 NIV)
"Mommy, please don't come at me with bad words - because they will get in me!" The tender young child who uttered these words of wisdom could just as easily have said the same thing to a Daddy. One local school teacher has the indescribable joy of working as a teacher of our young children in the community. One of the parents told how her child had shamed her when she was using some bad language to make a strong point about the child's misbehavior.
The time has finally come. That great computer that you bought five years ago is starting to show its age. It seems sluggish and slow, won't run some of the newer programs because it doesn't have enough memory (RAM) and you have already added all you can. So you finally bite the bullet and buy a new replacement. You get your new computer home and transfer all of your data files from the old computer to the new one.
So, what do you do with the old computer now?
This Friday past, Peyote Pete confirmed that the blues are running. I've lived most of my life by saltwater. I can't tell you how many times I've heard that call, "...the blues are running." It's as exciting now as it has always been from the Northeast down through Florida and across the Miracle Strip. I have a wooden plaque endorsed by the Governor of Virginia for a citation blue, seventeen and a half pounds, hooked off the Eastern Shore.
I remember as a kid we used to say, "Wind from the west, fish bite the best; wind from the east, fish bite the least." I don't remember any sayings about the north or south winds. But, when the wind blows in that pristine clear water from down around Crystal River our inshore fishing gets much better.
Now I will grant that the fish will allow you fewer mistakes in clear water, especially redfish, but the clear water more than makes up for the disadvantages it brings.
Someone told me as a writer you are best to write about what you know best. If you adlib, the readers will know you're a phony. That kind of narrows things down for me, because as a writer what I know best is limited - limited, that is, to education and aviation. Most of my years have been spent in that area of expertise.
Oh, I have done a lot of things in my lifetime other than education and aviation. I guess you could say I'm somewhat experienced in raising children. I've had four children, but so has everyone else, so who wants to know about rearing children? Boring.
Mulberry trees grow hereabouts. Trimmed a certain way, you might even call them bushes. Right now, the mulberries are ripening. The fruit is dark colored, nearly black, clustered much as blackberries. The flavor is gentle and sweet unlike blackberries, which are strong and tart. As with most fruits, there are many ways to serve them, most generally mixed with other fruits, over cereal, over ice cream, or baked in pies and pastries.
One of the great things about writing this column, is I am not held to any one subject or theme. I can write about anything I want as long as it is tasteful and generally entertaining. And, I try to be entertaining but the words don't always come out that way. I do get some negative mail once in a while.
You know the "ole cliché, "You can please most of the people most of the time, but you can't please all the people all the time." This is usually the case with writing publicly.
Copyright © 2019
The Cedar Key Beacon is your source for local news, sports, events, and information in Levy County and Cedar Key Florida, and the surrounding area.


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I've come to be friends with Stephanie Lemoine because of my late sister Ruthie. Stephanie was one of Ruthie's "chemo buddies," by which I mean they were cancer sufferers who met and became close in the Baton Rouge General's chemotherapy room. Stephanie went into remission; Ruthie, of course, didn't make it. I've gotten to know Stephanie since I returned to south Louisiana, and she's a key part of The Little Way Of Ruthie Leming.
Stephanie's cancer returned, and she's been having a very, very hard time of it. The last time I visited her, she told me that she began noticing that during her lowest times, sometimes after she had been praying with particular intensity — especially asking for her late friend Ruthie's prayers — a cardinal would appear outside her window. She had come to see it as a sign of Ruthie's faithful presence at her side as she was on this painful and difficult journey through the land of cancer.
Today we went to Sunday dinner at my mother's house. She told me that Stephanie is about to go back to M.D. Anderson in Houston for another round of grueling cancer treatment. She — my mother, I mean — was sitting out on her front porch late last night, in the dark, praying for Stephanie, when she heard a loud rustling noise in the bush next to the porch. She shined her flashlight to see what was making the noise, and there she saw a cardinal.
Cardinals are diurnal birds. You never see them at night, and when you see them in the daytime, they are quiet, unfussy birds. But there was one in the bush next to my mother, making noise as she prayed for Stephanie. My mother took it as a sign of Ruthie's presence for and with her faithful friend, and it gladdened her heart. It gladdened Stephanie's heart too. And mine. I believe it.
Please pray for Stephanie Lemoine, if you pray.


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Peltzman Says Regulation Aided Failureby Greg Slisz '10 • April 7, 2010 Share:
In the aftermath of a financial crisis that left bank failures and stunned investors in its wake, people around the country have tried to explain what exactly caused the downturn. Dr. Samuel Peltzman addressed what he perceived to be one of the main causes of the crisis in his Rogge Memorial Lunchtime Talk titled "Regulation and the Financial Crisis." In the talk, Peltzman analyzed how increased regulation has actually led to more risky behavior from the banks.
Watch Peltzman's evening talk on Wabash YouTube page or at bottom of this page.
Peltzman, an economics professor at the University of Chicago and editor of the Journal of Law and Economics, began the lecture by explaining the two main types of regulation which the government imposes on the banks. While the first types of restrictions, those on the services offered by banks, have mainly been removed over the years, the second kind, regulations on financial safety, have steadily increased, Peltzman said.
Peltzman detailed the reasoning why this second type of regulation, which includes requirements for a bank's capital ratio as well as its portfolio risk, were actually not even necessary until after the invention of Federal Deposit Insurance in 1933. Until this time, Peltzman said, free market competition should have, in theory, caused institutions with higher levels of risk to also yield higher interest rates for their depositors.
However, with the advent of Federal Deposit Insurance, Peltzman explained, depositors no longer cared what kind of assets or capital ratio their bank possessed due to the fact that their assets were now insured against loss.
Likewise, banks themselves had little incentive not to take risks. In an example he dubbed "Bank 'A' Goes to Las Vegas," Peltzman showed the way in which a bank's stockholders are essentially given incentive to "gamble" on risky investments that yield an average positive return due to a high leverage ratio as well as the fact that the US government now protects them from losing their deposits.
Evidence of this risky behavior, Peltzman illustrated, could be witnessed in the years after the advent of deposit insurance, as leverage ratios fell from 18 to 8 percent. After the first big bank bailout, which occurred during the savings and loan crisis in the mid 1980s, the government responded again by creating FDICIA, a law that forced banks to hold higher capital to asset ratios but said nothing about risk. The problems, Peltzman said, persisted, as banks responded to this by investing in a high volume of risky assets, including the debt of developing countries.
Once again, the government reacted with more regulations and created a risk-weighted capital ratio requirement. This, Peltzman said, has helped lead us to the current financial crisis. Banks, faced with these regulations, either tried to convince the government that the assets, which included risky subprime mortgages, were safe, or they moved the assets off their balance sheet altogether and sold the assets to an investment bank or hedge fund. However, the banks failed to take into account that the risks of all these risky mortgages could have been correlated, and as housing prices declined, banks failed across the board.
Because many of these banks were deemed "too big to fail" due to their large quantity of assets held, the federal government felt that it had no choice but to bail them out in order to prevent a collapse of the financial system. Peltzman said that this concept, combined with the fact that the government now extends guarantees to even uninsured deposits, means that moral hazard will continue, likely leading to more financial crises in the future.
Peltzman, in contrast, proposed two alternative solutions, one in which risk was prohibited, and another in which banks, even those that were "too big to fail," could do what they wanted, but also pay the consequences. Ultimately, Peltzman concluded that the second of these two options would have to be the long-run solution for the US if it wished to avoid future financial crises.
The Rogge Memorial Lecture and Lunchtime Talk are dedicated to the memory of Benjamin Rogge, a former dean and economics professor of the college.


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The revised and expanded paperback edition is now available!
Buy it: Amazon | Barnes & Noble | Powells
Bright Blue Music
- Watch More Musicophilia Videos
- More Video and Interviews on OliverSacks.com
Look Inside the Book
"Dr. Sacks writes not just as a doctor and a scientist but also as a humanist with a philosophical and literary bent. . . [his] book not only contributes to our understanding of the elusive magic of music but also illuminates the strange workings, and misfirings, of the human mind."
- Michiko Kakutani, The New York Times
"Oliver Sacks turns his formidable attention to music and the brain . . . He doesn't stint on the science . . . but the underlying authority of Musicophilia lies in the warmth and easy command of the author's voice."
- Mark Coleman, Los Angeles Times
"His work is luminous, original, and indispensable . . . Musicophilia is a Chopin mazurka recital of a book, fast, inventive and weirdly beautiful . . . Yet what is most awe-inspiring is his observational empathy."
- The American Scholar
"[Sacks] weaves neuroscience through a fascinating personal story, allowing us to think about brain functions and music in a bracing new light . . . Human context is what makes good journalism, medical and otherwise. That's the art of Sacks' best essays."
- Kevin Berger, Salon
"[Sacks's] lifelong love for music infuses the writing . . . Musicophilia shows music can be more powerful (even dangerous) than most of us realize, and that defining it may be crucial to defining who we are."
- Andrew Druckenbrod, Pittsburgh Post-Gazette
"Sacks spins one fascinating tale after another to show what happens when music and the brain mix it up."
- Newsweek
"Sacks is adept at turning neurological narratives into humanly affecting stories, by showing how precariously our worlds are poised on a little biochemistry."
- Anthony Gottlieb, The New York Times Book Review
Musicophilia, a New York Times bestseller, has been named one of the Best Books of 2007 by the Washington Post and the editors of Amazon.com
Music can move us to the heights or depths of emotion. It can persuade us to buy something, or remind us of our first date. It can lift us out of depression when nothing else can. It can get us dancing to its beat. But the power of music goes much, much further. Indeed, music occupies more areas of our brain than language does--humans are a musical species.
Oliver Sacks's compassionate, compelling tales of people struggling to adapt to different neurological conditions have fundamentally changed the way we think of our own brains, and of the human experience. In Musicophilia, he examines the powers of music through the individual experiences of patients, musicians, and everyday people--from a man who is struck by lightning and suddenly inspired to become a pianist at the age of forty-two, to an entire group of children with Williams syndrome who are hypermusical from birth; from people with "amusia," to whom a symphony sounds like the clattering of pots and pans, to a man whose memory spans only seven seconds--for everything but music.
Our exquisite sensitivity to music can sometimes go wrong: Sacks explores how catchy tunes can subject us to hours of mental replay, and how a surprising number of people acquire nonstop musical hallucinations that assault them night and day. Yet far more frequently, music goes right: Sacks describes how music can animate people with Parkinson's disease who cannot otherwise move, give words to stroke patients who cannot otherwise speak, and calm and organize people whose memories are ravaged by Alzheimer's or amnesia.
Music is irresistible, haunting, and unforgettable, and in Musicophilia, Oliver Sacks tells us why.
Listen to an audio excerpt from Musicophilia:


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I've been spending waaaaaayyyyy too much time playing games when I should be recording my next album. (Shame I know)
Skyrim is in a league of its own in terms of open-ended gameplay and sandbox world. I can't think of anything that comes close. Probably for the best. I don't have time for such extended adventures.Right now, I'm playing Final Fantasy 14 (MMORPG) on PC
This is sort of contradictory. You're playing an MMORPG, which are the most time consuming games out there, but don't have time for Skyrim.
[...] but the upcoming crowd funded "Star Citizen" and "Elite: Dangerous" are very, very interesting (and very good looking) projects.


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MLB.com sits down with Tommy Hutton
MIAMI -- Fox Sports Florida analyst Tommy Hutton is entering his 18th season broadcasting Marlins games.
Entertaining, informative and opinionated, Hutton has seen plenty of highs and lows over the years as a player and now an analyst. The 2014 season is a milestone for the veteran broadcaster, as it marks his 50th season in professional baseball.
MIAMI -- Fox Sports Florida analyst Tommy Hutton is entering his 18th season broadcasting Marlins games.
Entertaining, informative and opinionated, Hutton has seen plenty of highs and lows over the years as a player and now an analyst. The 2014 season is a milestone for the veteran broadcaster, as it marks his 50th season in professional baseball.
A year ago, the Marlins went through a frustrating 62-100 campaign, but Hutton now sees some encouraging signs for the organization. In anticipation of Opening Day on Monday against the Rockies at Marlins Park, Hutton sat down with MLB.com to share his insights on what to expect in 2014.
MLB.com: After watching the club in Spring Training, what stands out heading into Opening Day?
Hutton: One of the fun things about coming up to Spring Training and watching the games, and watching the workouts, and talking to the coaches, and talking to the manager, and the players, and some of the new players, is that you always get a feel of a little different attitude. You sense what's going to be in the clubhouse and what's going to be on the field. It's been a good spring, as far as the players who have been brought in. Some holes have been filled. I think they've done a good job, and it's a good group of guys to watch so far.
MLB.com: The strength of the team? I imagine you'll say pitching. As you look at pitching, what do you kind of see in this rotation?
Hutton: Strength of the team is pitching, and power in right field. How about that analysis? If the starting pitching does what everybody expects, it could be exciting. You wouldn't expect anything differently from Jose Fernandez. You see the way he works. You want to see improvement from Nate Eovaldi. You want to see improvement from Henderson Alvarez. Then you have guys vying for the numbers four and five spots, and you hope that works out.
MLB.com: There seems to be more pitching depth than in previous years, isn't there?
Hutton: Where you feel good about that if you're a Marlins' fan is that, if certain things don't work out, there is some good depth in the pitching. We've all seen that with some of the youngsters coming up. The pitching certainly is a strength, especially the starting pitching.
MLB.com: How about the bullpen?
Hutton: I think the bullpen is going to be a little better, too.
MLB.com: There seems to be a lot of guys who can throw 95, 96, 97 or higher. That's something we haven't really seen in the past with this organization.
Hutton: Well, you like that, and you like those power arms setting up Steve Cishek, who was tremendous last year. Steve's a guy who gives right-handed hitters such a crazy look.
MLB.com: Obviously, offense is going to be the big key. Are they going to be able to score enough runs? What are you seeing from the offense?
Hutton: After last year, they have to score more runs. I think with the improvement at third base, Casey McGehee, I've talked to him. He certainly learned a little bit in Japan. My feeling is, if you don't learn how to hit the fork ball, and all the off-speed stuff they see in Japan, you're not going to last there. He had a solid year there last year. He's going to give you some power.
MLB.com: How about some of the other moves?
Hutton: Garrett Jones has averaged 20 home runs a year for five years in a row. He should help at first base. [Jarrod] Saltalamacchia behind the plate should be an improvement as far as hitting. You hope Christian Yelich gets better, and Marcell Ozuna gets better. Then all those outfielders will fall into place.
MLB.com: Giancarlo Stanton, obviously, we all know what happened to him last year. He got hurt. It wasn't his finest season. He's had a very good spring. What do you expect from him?
Hutton: Just keep him on the field. Stay healthy. If he does, I'm a firm believer that with the way he hits, and the kind of power he has, if he's healthy for 145-150 games, he's going to hit 35 or 40 home runs. He has that ability.
MLB.com: Do you think this team has the capability to surprise some people? They make it clear: this is a process. They're not trying to do many shortcuts. Is this the type of team, with a second Wild Card, that might have a shot if all things fall right?
Hutton: I'm not going to go there yet. But I think it's the type of team that if you're the Braves, if you're the Nationals or you're the Phillies, you don't want to play them. You're looking at the rotation and you don't want to face Jose Fernandez. You might not want to face Eovaldi. So it's a team that's going to give those teams some trouble.
Joe Frisaro is a reporter for MLB.com. He writes a blog, called The Fish Pond. Follow him on Twitter @JoeFrisaro.


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Winter does a number on skin, from head to toe. But it's possible to resist letting the dry winter air wring every drop of moisture from your skin.
"It's an environmental problem," says Dr. Nicholas Perricone, dermatologist and author of "Forever Young: The Science of Nutrigenomics for Glowing, Wrinkle-Free Skin and Radiant Health at Every Age."
Much attention has been given to the summer skin problems that come from the sun's damaging rays. Winter brings other issues.
As the temperature drops in the winter, fewer water vapors circulate in the air. Then we crank up the furnace to warm our homes, further depleting available moisture. And our skin takes a beating, Perricone says.


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Todd Wilbur needed a new logo design and created a contest on 99designs.
A winner was selected from 243 designs submitted by 70 freelance designers.
For the last 18 years Todd Wilbur has been developing amazing home recipes that clone the taste of America's famous brand-name foods. His Top Secret Recipes books have sold over 4 million copies, and http://www.TopSecretRecipes.com is the world's most recognized website for original taste-alike recipes. Top Secret Recipes is developing a wide range of food products that will also use this new logo.
There are no specific requirements for this logo other than is should reflect the fun attitude of the books, website and videos Todd has created. Also, Todd prefers to think of himself more of a mad scientist rather than some sort of spy who is sneaking around to obtain these formulas. That is why the current logo features a beaker image.
Find out how a design contest works or learn more about our logo design services.


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Lincoln Road Farmers' Market
February 4, 2018 @ 9:00 am - 6:00 pm
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Weekly on Sundays
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On Sundays from 9 a.m. to 6:30 p.m., find such farmers market staples as fruit, vegetables, plants, honey and more. The market stretches along Lincoln Road from Meridian Avenue to Washington Avenue on Miami Beach.


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BOSTON, Mass. – Five unanswered goals in the first half helped propel the MIT women's lacrosse team to a 15-11 victory over NEWMAC foe Emerson College on Tuesday night. Freshman Hannah Levy (Yardley, Pa.) amassed a game-high seven points on four goals and three assists for the Engineers who improved to 10-5 on the year and 3-3 in conference action.
Sophomore Isabella DiDio (Jenkintown, Pa.) tallied four goals, two assists, six draw controls, four groundballs, and one caused turnover in the win. Sophomore Kira Schott (New Canaan, Conn.) registered three goals and five draw controls while freshman Keeley Erhardt (Ann Arbor, Mich.) scored twice. Sophomore Kristyn Berretta (San Diego, Calif.) and freshman Tate DeWeese (Towson, Md.) both tacked on a goal as junior goalie Candice Kaplan (Arlington, Va.) made six saves. As a team, the Cardinal and Gray converted seven of its 12 free-position attempts.
Emerson got on the board less than two minutes into the game but MIT countered with back-to-back free-position shots by Levy and DiDio. An exchange of goals ensued as the Lions evened the score at four at the 19:04 mark. During the next 10 minutes, the Engineers responded with three straight goals from DiDio, a Levy free-position marker, and a solo effort by Schott to go ahead for good. Emerson ended its scoring drought as both sides traded goals with Erhardt's blast giving MIT an 11-6 lead with 2:28 remaining before halftime.
Berretta increased the Engineers' advantage early in the second stanza; however, Emerson put together a 3-1 spurt to narrow the gap to four (13-9) with 20:07 on the clock. MIT controlled the action but could not break through until Levy found the back of the net with 7:30 left to play. The Lions ended their scoring drought a minute later and registered their last goal with 2:25 to go. DeWeese provided the final marker when she connected on a pass from Levy right before the horn sounded.
MIT wraps up regular-season play on Saturday, April 19 when it hosts NEWMAC rival Mount Holyoke College.


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A new smartphone game developed by two Britons, one an award-winning novelist, with funds raised by crowd-sourcing and no budget for marketing, has become the world's highest-grossing health and fitness app during its first fortnight of release, beating even such giants as Nike.
Released just weeks ago, Zombies, Run! describes itself as "an ultra-immersive running game for the iPhone, iPod Touch, and Android" with a narrative edge.
Instead of focusing on fitness, it casts the user as the struggling survivor of a zombie apocalypse. Players undertake sorties to gather supplies, with the drama playing out in fully scripted audio; success is measured in further segments of the unfolding story.
Sales are expected to top £100,000 ($194,000) soon, despite the full version costing more than £5, and media specialists say the game's success has many lessons for the industry.
The game is the brainchild of Adrian Hon, founder and head of London games studio Six to Start; and Naomi Alderman, Orange prize-winning novelist and game writer.
Alderman says their inspiration was a "learning how to run" course she took last year. "At the start of the course the instructors asked us why we wanted to learn to run. Most people talked about getting fitter, but one woman answered 'to escape the zombie horde'!"
The idea stuck and, when Hon told her about his ambition to develop a fitness app that "made the actual act of running itself fun", Zombies was born.
Crucially, the pair decided that rather than truing to raise funds from a conventional investor or games company, they would use the website Kickstarter to crowd source their budget. A three-minute video pitching the game was uploaded to the site last September and swiftly captured the internet's imagination. Pledged funding of US$73,000 ($89,000) from 3464 donors poured in - more than five times the initial target - as well as more than 30,000 "likes" on Facebook. They raised their money and ensured the project's viability.
The lesson seems to be: give people something fresh, gripping and alive to play to its audience's interests, and they'll not only pay a premium price, they'll pay up front for you to make it.
- Observer


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The Seattle Japanese Garden's 2014 season opens on Saturday, March 1 with a celebration from 11 a.m. to 3 p.m. To ensure a wonderful season, Reverend Koichi Barrish of the Tsubaki Grand Shrine will honor the Japanese Garden with the traditional Shinto blessing at noon.
This 3 ½ acre formal garden evokes another time and place, a unique and artistic representation of nature influenced by Shinto, Buddhist, and Tao philosophies. Designed and built under the supervision of world-renowned Japanese garden designer Juki Iida in 1960, the garden is a quiet place, allowing reflection and meditation through the careful placement of water, garden plants, stones, waterfalls, trees and bridges.
Admission fees for First Viewing are: $10 for adults 18-64, $5 for youths 6–17, senior adults 65+, college students with ID, and people with disabilities, and free for kids younger than 6.
For free, the community is invited to enjoy the opening of a beautiful new photography exhibit "A Celebration of Spring" from 11 a.m. to 3 p.m. in the Tateuchi Community Room. The juried show also on March 1 celebrates nine photographers and their fantastic views of the Garden from a spring workshop in 2013.
The Japanese Garden offers monthly tea presentations and demonstration at the Tea House and other great community events during the March -November season when it is open to the public
Seattle Japanese Garden 2014 Schedule
March 1 – March 30 Tuesday – Sunday 10 a.m. – 5 p.m.
March 31 – Sept. 21 Monday – Sunday 10 a.m. – 7 p.m.
September 22 – Sept. 30 Monday – Sunday 10 a.m. – 5 p.m.
October 1 – Nov. 2 Tuesday – Sunday 10 a.m. – 5 p.m.
November 3 – Nov. 30 Tuesday – Sunday 10 a.m. – 4 p.m.
The Japanese Garden is located at the south end of the Washington Park Arboretum at 1075 Lake Washington Blvd. E. For more information please visit http://www.seattle.gov/parks/parkspaces/japanesegarden.htm or call 206-684-4725.


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Brisco Responds To Yung Berg (Defending Flo Rida) "You Talkin Too Much, I'ma Beat Yo Lil Red Ass"!
Brisco responding to Yung Berg's comments about Flo Rida from WhatsPoppin.Net interview. Shout out to Davian
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Views: 164
Dan, agreed. in my relatively short time here on AN, i've seen more than a few crackpots. however, it's amazing how few real disagreements i come across on this site. i'd say that 90% of the members share near identical worldviews on multiple topics.
anyway, welcome Vincent. hope to see you in some discussions.
Hello there! Nice to have you on the site!
I have a delusion: it has to do with my finding a Playboy centerfold type.
Hell, I deserve a delusion; I'm eighty one.
I have no delusions about my pond scum ancestors.
Ok, blue-green algae if you insist.
Welcome, Vincent, to uncertainty.
I have plenty of delusions, just not religious ones.
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The oSIP library - News
posted by aymeric, Mon 16 Jul 2012 10:48:44 PM UTC - 0 replies
The new git branch "osip4" has been under development for the last few months. The branch has been renamed to become the official "master" and default branch for osip2.
osip2-4.0.0 will be released very soon! You can already use this new stable git which contains all latest patch.
[Read more]
posted by aymeric, Tue 01 Mar 2005 11:42:09 PM UTC - 0 replies
My last news was posted around 2 years ago. Despite this, osip has now evolve to a really stable and mature sip stack.
I'm pleased to announce that I'm now able to provide support (and much more like external developpement or just my valuable sip experience) through my own company.
Come and visit me at http://www.antisip.com
Sometime, you can call me at sip:firstname.lastname@example.com
posted by aymeric, Mon 27 May 2002 11:39:38 AM UTC - 0 replies
Thix release correct a few minor bugs and improve the compliance with the rfc2543bis-09 draft.
posted by aymeric, Mon 06 May 2002 11:11:50 AM UTC - 0 replies
This release is compliant to the latest SIP draft. You can test it with http://osip.atosc.org/download/jousa-0.5.5.tar.gz
posted by aymeric, Tue 12 Feb 2002 04:48:06 PM UTC - 0 replies
This is the first release of the development branch 0.8.X.
You can download it at:


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What is my role in the grievance process?
After you file a complaint, you are called the Complainant. You can provide useful information to the
grievance panel investigating the complaint. If probable cause is found, you can help disciplinary counsel establish the case against the attorney. Disciplinary counsel does not have to call you as a witness at the public hearing, but
if probable cause of misconduct was found you are entitled to make a statement to the Statewide Grievance Committee.
7. Who can I complain about?
This office accepts grievance complaints against individual attorneys. We do not accept grievance complaints against judges, probate judges, or state employees. We do not accept complaints against state employees, who are also attorneys, if the complaint involves their official duties or decisions they made.
8. Can you find me a new attorney?
No. Because this office investigates and disciplines attorney, it would be a conflict for us to provide you with the name of an attorney that can help you with your legal problems. You can contact a
private bar association for a referral.
11. What is the discipline process?
See Discipline Process Frequently
Asked Questions.
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For many families, between school, extracurricular activities, their social lives – not to mention parents' busy schedules – it can be hard to fit supplementary Jewish studies into their lives.
Starting this year, two Canadian synagogues are hoping to offer a more flexible option with the introduction of a program that partners with ShalomLearning, an American company that provides a system of online education.
Although the program has existed in the United States for two years, this is the first time the company has targeted a Canadian audience.
"We're reaching out globally," said Sarah Steinberg, CEO of ShalomLearning. The former executive vice-provost of Johns Hopkins University said she spent years focusing on online education, examining the differences between online and in-person studies.
The learning outcomes have proven to be identical, if not better in secular studies, she said.
"In some cases [the results are] better when you're learning online, because you have the advantage of being able to slow down a recording or take an extra time to look at something again," she said.
She said although she isn't aware of any studies focusing on faith-based education, "I have no reason to doubt that the findings are exactly the same."
Beth Tzedec Congregation in Toronto added the program this year for congregational school students learning Hebrew in grades 4 and up.
Daniel Silverman, the shul's director of education and family programming, said the school is hoping it will make it easier for students to take the class, despite their busy schedules.
For a number of years, the school has offered an option of having teachers come to students' homes if they couldn't make it to class, but this meant the teachers were driving to several houses a week.
Now with the online option, the teachers can teach two online classes, cutting down on the number of in-home tutorials.
"It's really amazing that basically you're running the same sort of class," Silverman said. "It may even be a little more interesting to the students, to students who are tech-savvy and like to have that relationship through the computer."
In Montreal, Temple Emanu-El-Beth Sholom also began using the program this year for its Grade 7 bar and bat mitzvah class. Like Beth Tzedec, the online lessons at the temple are only one component of the class.
Ali Maislin teaches both in class and online at that synagogue, and she said that so far, the two are not so different.
"We're all online together. We can all see each other. In that sense it's like sitting together," she said.
The biggest hurdle for her was learning the system and finding ways to help students who might have technical difficulties while trying not to let it affect the other students. But she noted that multitasking is a big part of teaching in the classroom, too.
Theoretically, if synagogues were to expand their online course offerings, it could offer the opportunity for Torah study to people who don't have a synagogue in their city, Steinberg said.
But there's still a while to go before the shuls are ready to tackle that audience.
Rabbi Lisa Grushcow, the temple's spiritual leader, said that although the classes enrich the program, she's adamant that the online classes could never replace in-class instruction.
"It's all a balancing act. You want to have an open door, and sometimes that means flexibility and accommodating where you can, but you want there to be substance, and part of the substance is community," she said.
Even ShalomLearning's first partner, Congregation Beth El in Bethesda, Md., which has seen the positive results of online faith-based learning first hand, wouldn't consider using it as a total replacement.
"It's harder to really create community online," said Geryl Baer, the shul's director of community engagement. "It's a great platform for some of the education, but they miss out on the social aspect. There's something positive about being comfortable in the synagogue."


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Beefeater to March Out a Summer Edition
- May 14, 2010 |
- By Jack Bettridge
Coming on the heels of last year's superpremium debut, 24, Beefeater Gin is set to introduce a lighter, brighter seasonal gin in June, called Beefeater Summer Edition. The new vehicle, which will only be available until fall, is aimed toward refreshment, with its three new botanicals and lighter proof.
Inspiration for the added botanicals—elderflower, black currant and hibiscus—comes from the summers of the English countryside, says Beefeater. The company, which is the only gin still made in London, stayed closer to home than it did with the grapefruit-and-Asian-tea-inspired 24.
Unsurprisingly, flowery is the thrust of this gin, even as it includes the standard Beefeater botanical lineup: juniper, Seville oranges, lemon peel, licorice, coriander, angelica root, angelica seeds, almonds and orris root. The flagship gin is notoriously anchored to a dry, junipery profile. The Summer Edition is a traipse through a meadow of fruits, flowers and candy, with a very soft mouth feel for cushioning.
Meant for warm weather consumption, Summer Edition drops in alcohol from the 94 proof of Beefeater London Dry to 80 proof, a change which contributes to its lighter, softer character. Beefeater 24, at 90 proof, is the most expensive of the trio at $30. London Dry is $20 and Summer Edition $22.
The company suggests a spectrum of seasonal cocktails, including a Martini garnished with the fruits of summer:
Beefeater Summer & Cranberry
1 part gin
3 parts cranberry juice
Squeeze of fresh lime juice
Combine ingredients in a tall glass with ice. Garnish with lime wheel.
Summer Martini
3 parts gin
1 part dry vermouth
Stir together in a glass with ice until well chilled. Garnish with a blackberry and raspberry on a cocktail stick.
Summer Gin Fizz
2 parts gin
3 parts fresh ruby grapefruit juice
splash of club soda
Stir together in a tall glass with ice until chilled. Garnish with a wedge of ruby grapefruit.
Summer Lemonade
2 parts gin
3 parts homemade lemonade
Stir together in a tall glass with ice until chilled. Garnish with a lemon wheel.


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I've been riding the Fat Lady V1 and V2 for the last year and half. I originally replaced my 2010 16m Rebel with the Fat lady V1 after trying the Turbine, Dyno 16 & 18, Infinity V1 prototype(all 2011 models). I did not choose the Fat Lady V1 based solely on it's lowend. In fact, the Turbine, Dyno 18, and my Rebel had a touch more lowend than the Fal lady V1. I choose the Fat lady V1 because it was the most fun to fly out of the bunch. The Fat Lady felt more like a 13-14m kite with the lowend of a 16-17m kite. Just for the record, I weigh 200 lbs and ride the Fat lady with high volume surfboards(>34 lit.) in San Diego coastal conditions. For me, I don't bother riding unless it's over 9 knots since you can't really do anything with a surfboard in under 9, even 10 is a challenge with a descent size swell. Also, in light onshore wind, it's mainly upwind wave riding with some hacks and airs as you are riding out. When it jumps to 12-13 knots with more side-shore conditions, down-the-line wave riding is do-able on the Fat Lady. It turns faster than all the big kites I've tried and has good drifting abilties for such a large sail, maybe a combo of the low-aspect ratio of the kite coupled with the actual weight of the kite.
The new Fat Lady has more lowend the the V1. The turning seems a tad bit slower(still faster than your usual big kite) and a little less pivoty. . Also, the v1 had a little fluttering in the turn when you cranked it hard, where the V2 I haven't noticed. The kite also seems a little bigger than the first version and and a touch more of a higher aspect ratio. Hard to tell, but I will lay them on top of each other a snap a pic soon. All in all, I like the V2 better for overall performance. The V2 also looks a bit more durable than the v1 as evidenced in the bumbers on the leading edge and the neoprene covers over the strut clips.
I have been using a 23 inch Slingshot bar with 27m lines, the same bar that comes with the Turbine. Seems to work just fine.


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John Terry has escaped a lengthy injury lay-off after Chelsea confirmed he had suffered "no significant damage" to his knee ligaments in their Barclays Premier League draw with Liverpool.
The European champions announced captain Terry would be sidelined for "weeks rather than months" following an MRI scan on the injury that forced him off during Sunday's game at Stamford Bridge.
Chelsea posted on their official Twitter feed: "MRI Scans reveal no significant damage to John Terry's cruciate ligaments. He will be out weeks rather than months."
Copyright (c) PA Sport 2012, All Rights Reserved.


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Have a loved one affected with dementia? Get resources, recommendations, charts and advice for the support you need.
Download the eBook
Visit our newly remodeled Memory Care! Contact the Community at (301) 805-8422 to schedule a tour!
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text: Shields Challenge Achieves Double the Impact News Home 04.01.13 By: Buff Lindau In December of 2012, Saint Michael's announced The Thomas F. Shields '52 Challenge for Student Scholarships. Mr. Shields promised to match each of the first 100 gifts made of $1,000 or more for financial aid with his own gift of $1,000, for a total personal commitment of $100,000. Just three short months later, thanks to the vigorous and generous response of alumni, parents, faculty, staff, and other friends of Saint Michael's, we have met the challenge! Together, these donors have contributed a total of $202,400 in student scholarship aid. When you factor in Tom's launching commitment of $100,000 in, it brings the total to more than $300,000! "Saint Michael's must go the extra mile to help students get the education they desire and the scholarship aid they need," commented Jerry Flanagan, Vice President for Admission and Enrollment Management. "Thanks to Tom's generous matching challenge and a strong and swift response from St. Mike's supporters, we can do more, student by student." Saint Michael's extends its deep and sincere gratitude to Tom Shields and each and every contributor who helped to make the Shields Challenge a success!


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A medical marijuana dispensary in San Francisco is offering patients free joints every time a Giant hits a home run in the World Series. Commendably, Tim Lincecum was still in the dugout immediately following Juan Uribe's fifth-inning blast.
ReLeaf Herbal Center in San Francisco is promoting the local sports scene with free joints for fans present in the shop during each Giants home run in the World Series, and with a special discounted bright-orange strain and a THC-infused orange drink called "Giant Punch."
ReLeaf has been hyping the promotion ("We are burning up with Giants fever!") on their Facebook page. The Giant Punch post came immediately after a special "ReLeaf Field Poll," which asked, "Thinking about carrying medicated pizza pockets...would you try them? They are called pot pockets!"
Four people liked the pot pockets, and a thoughtful man named Mike wrote, "I'm pretty sure I would try just about anything with pot in it."
In related sports-n-substances promotion news, Hollywood's Whiskey Tango All-American Bar & Grill in Miami ("Redneck cool. Trailer-park fabulous. White-trash chic. Blue-collar vogue.") is extending its offer to pay customer's bar tabs for every Heat loss this season.
It's true. In 2010 there's nothing more American than sports, marijuana pizza pockets, and free booze.
San Francisco Pot Dispensary Offering Free Weed for Giants Homers [The Last Angry Fan]
After Heat Loss, Hollywood Bar Pays $4000 in Bar Tabs, Extends Promotion for Entire Season [Miami New-Times]
[H/T Jeff]


text:
Eastern Zing 8x11 Alb 3
By Caroline B
Related Products
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Product Information
- Type: Album Template
- Designer: Caroline B
- Software Category: Music
- Download Size: 60.1 MB (approximate)
Design Elements
- Digital Papers: 2
- Page Elements: 6
Designer Notes
Warm palette and generic kit on a MUSIC theme, this is Eastern Zing ! A 4 page Album made with my "Eastern Zing" Kits. NOTE : With album, you have not only perfect templates, but also the papers and embellishments used in it, that you could re-use separately in other projects. The price of each album depends on the number or papers and embellishments used.


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Ozone Rock and Shooter Mousepads
Ozone Mousepads
Published: 15th January 2013 | Source: Ozone |
Ozone Rock and Shooter
Soft mousepads are especially prone to spills and general daily grime, so we always like to keep an eye out for new models, knowing that it's an item that gets replaced a lot. Especially in the OC3D offices. Ozone have been providing cost-effective gaming gear for a while, so when a selection of their Rock and Shooter mousepads arrived we had to share.
All come rolled in a tube, and protected from the elements and fingers of curious children with a sturdy plastic packaging within the cardboard outer shell. You could carry this home in a storm without a bag and it would remain in mint condition.
The Rock is a giant of a mousepad, measuring 400x320mm. Available in green, blue and white it suits any desk, if you can fit its behemoth proportions on of course.
If you prefer red, then the Shooter is the one for you. Available in two sizes, the 420x320mm as with the Rock, alongside a much more manageable 320x270mm version.
3mm thick it's just the right depth to give the soft cushioning we enjoy, without sacrificing accuracy through sponginess. The coating sits nicely in the middle ground between speed and control, and with a very grippy rubber backing either model is a well-rounded offering. Affordable, comfortable and eye-catching. We like them a lot.
Thanks to Ozone for providing the Mousepads. Discuss your thoughts in the OC3D Forums.
Most Recent Comments
|The Rock is a giant of a mousepad, measuring 400x320mm.
My mousepad measure 1200mm x 600mm x 4mm Quote


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Brand Name: Peaceable Kingdom
Item#/SKU: 143339
Bubblegum Scratch-and-Sniff Stickers
Includes 45 permanent, acid-free stickers on 2 9"x4" sheets. Kids can never have too many stickers! Make sure to have lots on hand for fun little projects decorate, embellish, give them as gifts! With more than 75 designs to choose from, Peaceable Kingdom has got you covered in stickers! Ages 3 & up.
Orders of 24 or less stickers will be shipped for $7.50 in the United States. The shipping costs for larger quantities of stickers will also be adjusted. This offer cannot be combined with any other merchandise. This shipping charge will not be seen on your order, but will be adjusted manually and reflected on your receipt.
Our Price: $2.00


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9:00 pm
America ReFramed "90 Miles" Probing and thoughtful, Juan Carlos Zaldvar's 90 Miles is a personal memoir that offers a rare glimpse into Cuba, a country as mythologized to Americans as the United States is to the rest of the world. The Cuban-born filmmaker recounts the strange fate that brought him as a teenage communist to exile in Miami in 1980 during the dramatic Mariel boatlift. Zaldvar uses news clips, family photos and home movies to depict the emotional journey of an immigrant father and son struggling to understand the historical and individual forces shaping their relationships and identities in a new country. D
10:30 pm
Images of Tony Gleaton The cultural photographer's black-and-white portraits focus on the social construction of race and capture people separated from the dominant cultural group. These include photographs of black and American Indian cowboys, the African diaspora in Latin American, and the assimilation of Asians, Africans and Europeans with indigenous Americans. The documentary also explores how Gleaton connects with his subjects.G
11:00 pm
Global Voices "Putin's Kiss" Nashi is an increasingly popular political youth organization with direct ties to The Kremlin. Officially, its goal is to support the current political system by creating a future elite among the brightest and most loyal Russian teenagers. But their agenda is also to keep the political opposition from spreading their views among the Russians. D


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Yesterday's big hoopla from the NHL-NHLPA marathon stare down was the suggestion that each team in the league will now be permitted to buy out two contracts with amnesty against the usual buyout conditions.
Sure, there are lots of questions, and we know not of the strings attached, but let's ignore that for a second and assume this will be as easy as it could be. Which player(s) would/should/could the Canadiens use this privilege to strike from the books in 2013 and beyond?
I begin with the case of Scott Gomez. With the Canadiens in tight with the salary cap, the chunk of salary his buyout would free up under the cap makes him the first very obvious candidate for consideration in cap compliance land.
Advantages of a Gomez buyout
1. Salary cap room
Obviously. $7.3 odd million stricken from the records make it possible for the Canadiens to comply with the cap and explore other options
2. Replacing a player on the downswing with one on the upswing
Gomez is not on the upswing of his career. In fact, it appears to the casual observer that he is very much on the downswing. When he came to Montreal, he was producing less points, but there were many things in his game that were of great value to his team. The 2010 playoff run benefited greatly from his play. Two years removed from that time, however, and two seasons of even more dramatic decline leave Habs fans looking at a player that is more and more difficult to defend. His benefits have now become almost obscure. He is NHL level, but the relative benefit of icing this player vs. another have closed to almost nil.
The Habs have a fair number of players they should investigate at the highest level as they move forward in a rebuild. David Desharnais, foremost, would benefit from another season (part season) in a scoring role. Beneath him on the chart, Eller, Leblanc and even Galchenyuk are more important to the future Habs than is Gomez at this point.
3. Wingers for Plekanec
It is to Plekanec's eternal credit that he can play well with anyone and make almost everyone better. But for much of the past few years, this trait has hurt Plekanec's own freedom and production, and has hurt the team. Plekanec is probably the best offensive centre on the Canadiens club, yet with Gomez, Eller and Desharnais, he was not always given the wingers to show it. With Gomez out of the picture, it would seem that Plekanec's place with Gionta (at least) could be made permanent and his claim to the next best winger of the day would be solid.
Possible advantages of retaining Gomez
1. The value of a back-diving contract
It may be a foreign thought to most Canadiens fans, and a forgotten reality to others, but back-diving contracts like Gomez's were structured the way they were to a) compensate the player to the level he was asking up front, and b) make the contract tradeable in its latter stages.
The most compelling reason I can think of not to buy out Scott Gomez is that he is finally entering a stage in his contract where he is paid less than his cap hit suggests. This is of no value or interest to teams that make a profit and wish to maximize the use of their free cap space. But for teams that are not currently so interested in winning and would prefer to mitigate the damage of playing a season with no support for the loser team, then players like Gomez are of great help to get to a mandated salary floor.
This current season, Gomez was slated to be paid $.5.5 million, with $4.5 million next year. His cap hit endures at the magical $7.357 level. To a team in a US-middle-market rebuild, his contract represents $2m the $3m of money that never has to be paid.
For the Canadiens to use this as an asset would require finding a trade partner. I 'd suggest this could be possible, and should, of course, be explored.
2. If strings are attached...
I know I said we'd assume no strings attached on amnesty buyouts. But it's worth mentioning that if strings are to be attached it could very much influence this Gomez decision.
The Habs are a relatively weak team, and look to be that way until some long-term assets come through. I believe that Gomez's contract should expire before the team has to worry about playing a Western conference team in a playoff series.
If there is residual salary left over in the same way it is left over under the previous CBA, a Gomez buyout could do more harm than good, as it would extend part of his significant cap hit into years well beyond its expiry date. A 2015-16 team on the rise would be better off with full, clean salary options than to be burdened with the ghost hit of Scott Gomez.
Note: I did not mention a turnaround in Gomez's play, because frankly I believe that for a team in cap trouble like the Canadiens are, with few prospects of grand success this year or the next, a good year or two for Gomez would be irrelevant and certainly would not be worth the alternative measures it would require to become cap compliant.
The case for Gomez is actually pretty cut and dry really. As a player who is paid so much more than his play can possibly justify on a team with too little room to even pay their most important (and unsigned) player, he wears a permanent buyout sign on his back.
But as always, I would hate for the team and its management to take this decision too quickly without first considering the possible opportunities that could exist on the other side of the decision. We have seen too many times how decisions like that can take a team in its upswing to one dwelling in a basement.
In sum, I'd buy him out if nothing comes back from my enquiries to salary-floor sweepers.