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Generally, type 1 diabetes is managed with insulin therapy, diet, and exercise. However, in some cases, transplant of the pancreas or islet cells might be an option.
Pancreas Transplant
A pancreas transplant may be done if you:
- Have developed severe renal disease especially if you may need a kidney transplant
- Have tried insulin treatment, but it has failed to prevent acute complications, like diabetic ketoacidosis
- Have severe emotional problems due to insulin treatment
- Have frequent, potentially life-threatening complications, particularly hypoglycemia
Kidney damage is a common complication of type 1 diabetes. Many people with diabetes end up with kidney failure that requires regular dialysis . In most cases, a pancreas transplant is done along with a kidney transplant. There is good evidence that quality of life significantly improves if these 2 transplants are done together.
Some doctors, though, do transplant only the pancreas. This is done in cases where the patient does not have kidney failure. Compared to pancreas-kidney transplant, the benefits of just a pancreas transplant are not as clear.
If you receive 1 or more transplanted organs, you will need to take immunosuppressive drugs for the rest of your life. These drugs prevent the immune system from attacking your new organ. However, these drugs have many severe side effects, including high blood pressure , hyperglycemia, hearing loss, nausea, gastric ulcers , and bacterial and viral infections. Some of these drugs may increase your blood sugar level.
Islet Cell Transplant
Islets are cells located in the pancreas. Only a small percentage of the pancreas is made of these islet cells, which include alpha cells that produce glucagon and beta cells that produce insulin. During the procedure , islet cells are taken from a donor and, using a catheter (small plastic tube), are transplanted to the blood of a person with type 1 diabetes.
This procedure is still being studied. Researchers have found that the beta cells are very fragile. Many of these cells may not survive long-term. In addition, the immunosuppressive drugs seem to impair the insulin-producing ability of the new cells and cause side effects.
There has been some promising research, though. For example, people who have had an islet cell transplant may have better blood sugar control, and some may even be able to stop their daily insulin injections.
Revision Information
- Reviewer: EBSCO Medical Review Board James P. Cornell, MD
- Review Date: 09/2018 -
- Update Date: 09/17/2014 -


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Michigan State's Payne honored at Wooden gala
LOS ANGELES (AP) Adreian Payne of Michigan State was honored at the John R. Wooden Award gala on Friday night for his friendship with a cancer-stricken 8-year-old girl.
Payne received the first Outreach Award at the Los Angeles Athletic Club. He attended the gala three days after the death of Lacey Holsworth of St. Johns, Mich., who was stricken with neuroblastoma in 2011.
"She wouldn't want me to be sad," Payne said. "It's hard."
The crowd stood to applaud Payne, who spoke softly in accepting the award, saying he nearly didn't travel to Los Angeles after the girl's death but was encouraged to by her father.
"He told me Lacey would want me to come out," Payne said. "It's not just for me, it's for her. That's the main reason why I came."
Payne met Holsworth during one of her hospital stays just months after the death of the grandmother who raised him. Payne brought the girl to Michigan State games over the last two years, texted with her daily, and brought her on the court during Senior Day and the Big Ten tournament in Indianapolis.
"It was a great moment, especially for our team," he said. "To be able to share with Lacy just made it even better. I feel like a part of her family."
Michigan State lost to Connecticut in the East Regional final of the NCAA tournament on March 30.
"I just wanted to keep winning games because I knew she looked forward to it," said Payne, a senior headed to the NBA draft. "Once it was over it just seemed like she had nothing else to look forward to."
Holsworth joined Payne at the team's season-ending banquet and at a slam dunk contest during the Final Four last week.
"I learned so much, just seeing her fight every day," he said. "It's really been hard. She taught me to preserve through anything and just be strong."
A memorial service for Holsworth is set for Thursday at Michigan State's Breslin Center, the Spartans' home court.

subset: commoncrawl


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Extra roomy drawers. Smooth running drawers with pull-out stop.
It took a full day of hard work to assemble, and Ikea did not provide even one extra dowel or screw. Since then, this badly designed product has been nothing but trouble. The center piece on top that divides the 2 top drawers is way too heavy, and the holes were not put in correctly. It doesn't hold together in a number of places, and I have had to do major repair work on it, adding braces, nails, and screws, but the chipboard crumbles easily, drawers still don't fit right and connections keep working open. Apparently Ikea has dumped the whole line - a good move, but I'm still stuck with one of these things. If the company wants to offer me a refund, I'm very interested.
IKEA decided to discontinue the medium brown MALM line. So much for IKEA reliability.
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