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Thailand is the travel hub of Southeast Asia. Most visitors coming into the region fly into Bangkok and make that their base for doing the circuit as they backpack around Southeast Asia.
It's the most visited country in the region – and with good reason!
Thailand speaks for itself.
When you hear its name, you already think about beaches, beauty, jungles, and food. And your thoughts are spot on.
With its lush jungles, famed beaches, world-class diving, amazing food, friendly and cheap prices, Thailand is by far my favorite country in the world! I've been coming to the country since 2005, lived there for 2 years, and always seem pulled back to it. It's an easy country to travel and you can meet a lot of other people there.
Thailand has a lot to offer travelers – no matter your budget. You can backpack Thailand here on a limited budget or you can live the luxurious travel life in fancy resorts on the beach.
Or just travel on a modest budget and get a lot of bang for your buck.
The country has something for everyone.
Backpacking Thailand is often the way most people travel around but that doesn't mean really roughing it. You can travel Thailand well without spending a lot of money. I consider myself a backpacker but that doesn't mean I'm in dorm rooms all the time. You can get private rooms and nice meals for cheap.
The country is a well-worn destination on the backpacking trail and everything is convenient and easy. However, there are still many off the beaten path destinations away from the crowds and the prices they bring.
This Thailand travel guide will tell you how to travel the country like a pro, what to do avoid, how much things cost, the best things to see, and everything in between! You should use this guide if you're looking to a) backpack Thailand, b) looking for ideas on thing to do, or c) trying to travel on a budget.
Other Things to See and Do in Thailand
1. Visit the Grand Palace and Wat Pho
Thailand's royal palace was built at the end of the 18th century by King Rama I and is the official residence of the current monarch (though he doesn't live there anymore; now it's just used for ceremonies). It's a striking place filled with numerous temples, including Wat Pra Kaeo, which houses the 15th-century Emerald Buddha. Nearby Wat Pho is famous for two things: a larger-than-life golden reclining Buddha statue and a very relaxing massage school.
2. Visit Khao Sok National Park
Located in the south of Thailand, Khao Sok National Park is constantly rated as one of the best in Thailand, with incredible trekking, camping, limestone karsts, cooling rivers, and a glistening lake. You'll find semi-challenging hikes, tons of wildlife, walking paths, and incredible sunsets. Park entrance costs 200 THB (6 USD).
3. Hop around the ancient capitals
Between Chiang Mai and Bangkok are Thailand's three ancient capitals – Sukhothai, Lopburi, and Ayutthaya. Visiting them on your way north is a unique way to head from Bangkok to Chiang Mai. You'll get to learn about ancient Thailand and see rural life at its best. My favorite is Ayutthaya.
4. Relax on tropical islands
Thailand has a million and one beautiful tropical islands. Some are overdeveloped, while others only have a single bungalow on them. You'll find everything here. Some of the best islands here are – Ko Samet, Ko Taruato, Ko Lanta, Ko Chang, Ko Tao, Ko Jum, Ko Lipe, Ko Phi Phi, Phuket, the Similan Islands, and Ko Samui.
5. Partake in the Full Moon Party
If you like partying, there's no better party in the world than the famous Full Moon Party. The Full Moon Party is a giant festival-like party with a lot of drinking, dancing, and drugs. Each bar has its own sound system, so you'll hear different music loudly blasting onto the beach every few feet. The beach itself is lined with people selling alcohol, fire dancers putting on shows, and little booths selling glow-in-the-dark face paint. Sure, it is super touristy but that doesn't mean it's not a lot of fun and it's as much a part of Thailand as anything else.
6. Go jungle trekking
There are some great jungle trekking opportunities in northern Thailand. Be sure to go on a multi-day hike. The shorter hikes aren't as good and the hill tribes you visit are like visiting a rural impoverished Disney World. The biggest departure points are Chiang Mai and Chiang Rai. Don't book any tours ahead of time, you can book these sorts of outings through the hostel or hostel you're staying in closeby. If you book online ahead of time, you will pay more.
7. Go scuba diving in the Similan Islands
Scuba diving here is a popular activity because of the crystal clear waters and majestic sea life. The cheapest place to learn is on the island of Ko Tao, which caters specifically for dive trips. Most people don't go unless they're planning on diving. While you can dive all over the country, the Similan Islands offer the best diving. If you dive the Similan Islands, be sure to see Elephant Head Rock, and the reef houses plenty of fish, snappers, rays, and turtles. Day trips start at 3,700 THB (110 USD).
8. Learn to cook
Thai food is delicious and it's relatively easy to cook. All over the country, you'll find places to teach you, though the best are in Chiang Mai and Bangkok. Even if you don't plan to cook back home, at least you get to spend a day making and eating scrumptious food. Try the Chiang Mai Kitchen Cooking School, with courses starting at 800 THB (24 USD). There's also Ko Chang Thai Cooking with courses starting from 1,200 THB (36 USD).
9. Explore the Khmer temples in Isaan
There are many temples built throughout the region, all along the ancient roads connecting Angkor to the other villages. The largest of these is Phimai, located at the end of the ancient highway. In the Buriram province are two other magnificent Khmer temples only a few kilometers apart. Phanom Rung built on top of a hill and Muang Tum which is at the base of the hill.
10. Get off the trail in Isaan
One of the most under visited areas of the country, Isaan is mostly a land of farms and villages. This is a great place to escape the frantic tourist atmosphere of the rest of the country. It is not overrun by tourists, and you get a chance to experience Thai culture in a different, more personal way. I think it's one of the most interesting places in the country.
11. Take the day train
Taking the day train from Bangkok to Chiang Mai is not only cheaper but a much better way to see the countryside than the night train. Sure, you waste a day but you see the countryside, you experience how Thais take the train, and you're treated to vendors coming off and on every stop selling meals for 15 THB (0.45 USD). The day trip remains one of my favorite experiences in Thailand. Just make sure you have a good book!
12. The Elephant Nature Park
Sure you can come to Thailand and ride an elephant, but so many of them in this country suffer from abuse. An even better way to get up-close-and-personal to the animals is to volunteer at the Elephant Conservation Center near Chiang Mai. It's a phenomenal place, allows you to give back to the community, and lets you help and play with these magnificent animals all a once. After coming here, you will know why you should NEVER ride an elephant in Thailand. A one-day visit costs 2,500 THB (75 USD) for adults.
13. Admire Wat Doi Suthep
This stunning Buddhist temples lies in Doi Suthep-Pui National Park, 10 miles out of Chiang Mai. A tram or a trek up 300 steps will take you to the summit of Doi Suthep, where the glittering gold temple spire awaits you. The temple dates back to the 14th century and holds rare relics of Buddha. It's really is too beautiful of a view to miss, so don't leave Chiang Mai without visiting Wat Doi Suthep. Admission is 30 THB (0.90 USD). It's open from 6am-6pm.
14. Visit the Golden Triangle
The point where the Mekong River meets the Ruak River is known as the Golden Triangle. You can take a boat and head to the Golden Triangle Park, or check out some of the many Buddha statues and markets.
15. Ko Phi Phi
This is one of the most popular tourist islands in Thailand. From the famous of Maya Bay (made famous in The Beach) to the monkeys on the aptly named Monkey Beach to the diving and nightlife, there are reasons people flock here. Destroyed by the tsunami in 2004, the island has been rebuilt and developed to an even greater extent than before.
16. Ko Lipe
Located in southern Thailand, this semi-off the map island is one of my favorite places in the world. Here on Ko Lipe, the super friendly locals bring in the daily catch for amazing seafood. The beaches are beautiful, the water warm, and the island cheap. I came for three days and then lived here for a month. In the last few years, it has become very developed and it's not the sleepy little island it used to be but it's still way less developed than many other destinations in Thailand. Moreover, you're near a pristine and undeveloped national marine park where you can snorkel and enjoy some beaches to yourself!
17. Shop at the floating markets
Thailand is full of markets. Perhaps the most whimsical of these are the floating markets, which can be found throughout the country. Some of the best are Damnoen Saduak, in Ratchaburi, and the Taling Chan Weekend Floating Market in Bangkok. You'll find rickety boats piled high with colorful goods and eats. You'll get plenty of great photos! (Although it's become majorly touristy to go to the floating markets, you'll not want to miss a morning shopping from boat to boat.)
18. Backpack in Kanchanaburi Province
Here you'll find a lush forest perfect for trekking, though the history of this area is rather dark. The infamous Death Railway is located here, linking Burma and Myanmar, which were constructed during WWII by prisoners of war. This is also where you will find the Bridge on the River Kwai, built using POW labor and the subject of a both a film and a book. While it is a haunting reminder, it is an essential part of Thailand's history.
19. Motorbike through Northern Thailand
Around the Chiang Mai and Chiang Rai areas, there are lots of great routes. Many people rent bikes and tour the scenery. You can take a day trip, or you can take a couple of days – whatever suits your schedule. The Mai Hong Son Province offers a great loop that you can do starting in Chiang Mai and ending in Pai. Note: Make sure if you're renting a motorbike, you're comfortable with driving it and never (ever) drink and drive.
20. Relax in Pai
Pai has grown as a tourist destination in more recent years, but it is still a great place to escape some of the craziness of your larger cities. It is a true backpackers town, located in Northern Thailand. It is nestled in rolling green mountains and surrounded by waterfalls and incredible hiking trails. Be sure to take a day trip to the Tham Lot Caves, where you can take a stop off to swim in waterfalls and hot springs on your way there. Stay on the outskirts town in a lovely little bungalow, rent a bike, traverse the hills, and bathe in the cool waterfalls.
21. Go to Phuket
This island is the biggest destination for tourism in Thailand. You'll find great beaches and amazing activities this island, and if you stay away from Patong Beach, you can avoid most of the over-development and crowds. Phuket draws a lot of tourists, and if you really want to enjoy the area, get out of the main spots.


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Earlier this week I was at the Digital Nations 2030 conference in Auckland. There was lots of talk about the inevitability of artificial intelligence (AI), which got me thinking about how it relates to history as a subject. Here are a few bald statements and equally bald (and unanswered) questions about it.
Vincent O'Malley used and may have coined the term at a talk last year 'Fake history' when questioned by someone in the audience about the New Zealand Wars.
We know from fake news that the Right knows how to mobilise online, much better than the Left, and can flood social media feeds to the detriment of society.
Here in New Zealand, Hobson's Pledge is a perfect combination of the two, flooding both mainstream and social media with interpretations of colonial and Treaty history that are both wrong and harmful.
Artificial intelligence, like it or not, is a thing. It's happening (search results, image recognition, social media algorithms, Amazon suggestions are a few examples that most will recognise) and will only become more central to our lives (medical imaging and diagnosis, legal interpretation, internet of things).
As with many new technologies, the cultural sector will probably be slow to adopt it. Equally, the technology industry will probably be slow to see the potential of the cultural sector for AI applications.
How will the documentary heritage sector respond to this challenge? In a future where people will ask increasingly complex questions of their devices, what responses will they receive to questions like "when was New Zealand settled?", "what caused the New Zealand Wars?", "why did Māori sign the Treaty of Waitangi?"?
They're significant and contested questions, central to how New Zealanders understand their country and place in it. But who will be providing the answers? And if (as I hope) it's the history community and documentary heritage sector, what systems do we need to start thinking about now to meet it sooner rather than later?

subset: commoncrawl


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Very exciting things have been happening behind the scenes at Provenance Barossa lately!
Ember Pizza and Grill will be a family friendly restaurant with a relaxed atmosphere and exceptional food. They'll focus on local and sustainable goods and a desire to highlight the wonderful produce and producers of our region, and state.
An authentic Italian Wood fired oven will take pride of place in the restaurant and will be the workhorse of the menu, whilst also indulging their chef's passion for grilling, smoking and charring a variety of local produce.
Keep an eye on our page for more updates.


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RIP Macho Man Randy Savage 1952-2011
by admin
TMZ sadly reported today Macho Man Randy Savage suffered a heart attack while driving and died. TMZ spoke with Randy's brother, Lanny Poffo, who tells us the wrestling legend suffered a heart attack while he was behind the wheel around 9:25 AM … and lost control of his vehicle.
Rest In Peace
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Spring 2020 Tryouts for AA and above on Jan 11, Jan 18
by Cambrian Park Little League, 2020-01-07T05:47:56.000-08:00January 07 2020, at 05:47 AM PST
There are two tryout sessions on January 11th and Saturday January 18th for players in Double AA, Triple AAA and Majors. Please check in 30 minutes prior to the start time.
Tryouts take place at Steindorf with Majors and Triple AAA tryouts on the Majors field and Double AA tryouts on the Farm field.
Majors: 9am – 10:30am
Triple AAA: 10:30am – 12pm (10's trying up for Majors will go first at 10:30)
Double AA: 12pm – 1:30pm
There will be doc verification available at the snack shack if you are unable to make Wednesday's (1/8) doc verification at the steindorf cafeteria at 6pm.


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4 Best Compression Gear
The world of compression gear changes all of the time. Companies are constantly working on innovations that offer better muscle support, more comfort and sufficient compression to enhance circulation.
There are many options to choose among but some products are simply superior. Here's the best 2016 compression gear according to our experts.
RecoFit Compression Tights
When it comes to innovative products, this one is a definite winner. The Reco Fit Compression Tights are available solely for women and while costly, they deliver in a couple of ways.
The tights are crafted from a carbon-based fabric. This material is especially chosen due to the circulation enhancements it brings to the table. As a result, athletes and exercisers wearing the tights are capable of getting more oxygen and nutrients to their muscles. Apart from enhancing circulation, the specialized fabric offers ribbed massage while the tights are being worn.
The design is comprised of individual panels, each one designed to offer support to a specific muscle. Gradient compression is available, meaning that it's strongest in the bottom part of the tights and decreases upwards.
Several other features are worth mentioning and these include moisture wicking properties, heat dissipation, a supporting waistband, breathable mesh behind the knees
According to the manufacturer's official website, the company is currently working on a similar product for men.
Sugoi Men's Piston 200
As the name suggests, the compression tights are especially created for the needs of male athletes.
Sugoi Men's Piston 200 is a piece of therapeutic graduated compression gear. The tights are crafted from 72 percent nylon and 28 percent spandex – a lightweight and very durable combination. The compression is mild and while some athletes would definitely opt for more support, the tights still deliver in terms of reducing muscle fatigue/enhancing circulation.
As the name indicates, the tights feature the company's Piston 200 fabric. The range also features Piston 230 and Piston 140. Piston 230 is the fabric best suited for use during extreme workouts. Piston 200 will be perfect for people who exercise a lot but aren't pushing themselves too hard.
Flat seams are incorporated in the design to maximize comfort by reducing chaffing. The tights also feature a laser cut hem and a comfortable elastic waistband. The breathable fabric is also moisture wicking, which enhances comfort during intense workout.
Apart from tights, the Piston 200 range by Sugoi features shorts, socks and calf sleeves.
SureSport Arm Compression Sleeves
Upper body compression garments are often ignored because the legs have to deal with the strongest impact during exercise. Nevertheless, upper body compression garments can be equally beneficial.
SureSport Arm Compression Sleeves feature graduated compression, once again enhancing the circulation of blood and the oxygenation of muscle tissue. Support is provided to the forearm, the biceps and the triceps.
These sleeves are perfect for weight lifters, basketball players, softball, triathlon practitioners and other athletes that want to reduce the risk of muscle soreness in the arms. A latex-free design ensures comfort and sufficient compression without irritation.
Apart from being great in terms of supporting the muscles, the arm sleeves can also be used to warm up the muscles. This characteristic is particularly beneficial for the individuals that like to exercise outdoors and the ones that have their workout regime undisturbed in the winter.
Enerskin Unisex Calf Sleeve Set
While being somewhat costly, the Enerskin Unisex Calf Sleeve Set has many great characteristics that justify the expenditure.
The calf sleeves feature 75 percent polyester/rayon fabric and 25 percent Xtra Life Lycra. Medical-grade silicone taping is also available, which combines with the compression to deliver even more pronounced therapeutic benefits.
Because the compression calf sleeves feature Enerskin's Gastex trio of materials. As a result, the sleeves offer compression when needed, after which they can deliver sufficient elasticity. The trio ensures effective pressure distribution for ultimate muscle support.
These calf sleeves can be used to enhance performance, protect the calves against injury and treat issues like foot cramping, swelling, plantar fasciitis, varicose veins, heel pain and general leg pain. The graduated compression is sufficient enough to address all of these issues.
Apart from this wonderful item, the Enerskin range features an array of other compression products. These include knee sleeves, elbow sleeves, compression shorts, compression t-shirts and tank tops.


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From late November, 200 golden tickets will be concealed in 20g price-marked pack (PMP) outers of Amber Leaf Signature Blend, which enables retailers to enter a prize draw.
Fifteen of the 200 retailer entries will be selected at random to win £500 worth of Amber Leaf stock, with the remaining 185 retailer entries receiving £5 Love 2 Shop vouchers. Wholesalers who sold the 15 outers to retailers receiving the £500 prize will also receive a £500 cash prize to spend on a team night out. The competition will be supported in the wholesale trade with bespoke POS including A2 posters and wobblers.
Jeremy Blackburn, JTI's head of communications, said: "This competition aims to reward retailers and wholesalers for their support in helping to maintain Amber Leaf's position as the biggest tobacco house in the UK.
"As existing adult smokers look for greater value for money, PMPs can help retailers demonstrate to existing adult smokers that they are getting the best possible choice and value when making their tobacco purchase.
"There's never been a better time to stock up on Amber Leaf Signature Blend PMPs and we wish everyone the best of luck."
0800 163503


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Event detail
Hoarding: How to Help a Loved One (BEUHS183)
Workshop | April 10 | 12:10-1:30 p.m. | Tang Center, University Health Services, Class of '42
Kathleen Crombie, M.A. M.Ed, In Order to…Organize; Diana Gleghorn, MFT, In Order to…Organize
Therapists and Professional Organizers from In Order To...Organize based in Oakland, CA and Chicago, IL will share techniques, resources and ways to care for yourself when faced with trying to help a loved one struggling with hoarding issues. Learn how to focus on the person and less on the stuff while supporting the loved one to accept help in the face of a complex challenge; understand ways to support the emotional and physical challenges when faced with extreme clutter; creative ways to help when finances are tight or someone refuses help.
CA, email@example.com, 510-643-7754


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HOLLAND, Mich. – Albion College was represented in three of the four knockout round finals during the Michigan Intercollegiate Athletic Association Relays.
Rileigh Eding swam past Calvin College senior Anna Serino in the finals of the 50-yard freestyle. Eding, who was second to Serino coming out of the semifinal heats, lowered her time to 25.91 in the finals.
Alexandra Horman (50 butterfly) and Kaitlind Hooper (50 breaststroke) were the runners up in their respective events.
In relay events
- Eding and Hannah Erickson joined men Mac Robertson and Evan Wonner for first place in the mixed 200 freestyle relay (1:32.80)
- Anna Moore and Nicole McCann joined Jake Huttenlocher and Nate Kozycki in a runner-up finish in the mixed 200 medley relay (1:41.66)
- McCann, Horman, Erickson and Eding matched Calvin stroke for stroke in the 500 progressive relay. Ultimately, the Britons finished second. Their time of 4:45.46 was .14 seconds off the pace set by the Knights.
- First-year swimmer Courtney Swingewood was joined by Henning, Hooper and Horman for third place in the 400 medley relay (4:21.15)
"The team swam well with the tough week of training we had," Albion Head Coach Nick Stone said. "This meet is made to get a lot of swims done in a short period of time, which can be very taxing, but the Britons maintained energy and raced well against the conference competition."
The Albion swimmers and divers return to the pool tomorrow for a MIAA dual meet against Kalamazoo College.
Follow Albion swimming and diving on Twitter (@AlbionSwimming) and Instagram (albion_acsd) to keep up to date with everything about the Briton swimming and diving teams


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(Note: This was originally written on the 5th of February, 2017.)
What makes something worth our attention? A lot of money is invested in answering this question, in all of its various guises… a lot of money. As such the assumption is that the question has value and whilst that is likely true the fact is that it is much more interesting to consider a different, albeit similar question: what makes something interesting?
As is often the case, the quality of interesting being subjective makes it difficult to explore and therefore less popular in our world of interconnected musing and opining; there is no doubt about it, we vote with our eyeballs and the numbers on vague notions such as interesting are not good. Instead, let's have a list of The 7 Most Fascinating Things For 2017!
And that's okay. I mean, who has the time, right? Well, the fact is that the modern world of internet-centred living is simply too large for anybody to keep on top of; the idea of being up to date in the year 2017 is altogether ridiculous. Instead, the gems of the internet can be found if we instead choose to focus on whatever thing we care about in the moment and invest time in that above all others.
This isn't easy and never has been, however, now in the age of data perhaps we can find it that much easier to see both approaches to living and thus gaining the perspective that is crucial to discovering exactly what it is that we care about… what it is that we find interesting.


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Takes place the 3rd Saturday in June and the Saturday after Labor Day in September. A Wine Tasting Festival featuring 8 to 10 regional Pennsylvania Wineries, gourmet food purveyors and fine art and artisans with work chosen especially for the wine enthusiast. Live entertainment. Event takes place in the outdoor park beauty of the Penn's Colony event grounds.
More info: www.WineTimeattheColony.com
This is a comprehensive list with links to annual Wine, Food, Spirits and Beer Festivals around the world. View all worldwide festivals.
If you are involved in an annual festival that has a permanent home page available on the Internet, you are welcome to enter the information here.
Submit your festival here.
LocalWineEvents.com is the #1 ranked website for consumers who ARE ACTIVELY seeking local wine & food events to attend.
2020 © LocalWineEvents.com. All Rights Reserved. Privacy Policy | Copyright Statement | Accessibility Statement


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Search results
Ohio Native Plant Month APRIL!
to adopt a school or garden patch and individuals to plant native trees, flowers or grasses. ... a special seed blend, a garden club is making mud seed balls, a regional group is featuring a different ... natives. Parks, zoos, garden clubs, the nursery industry, etc. are all thinking of creative ways to ...
OSU Extension, Lucas County's 2020 Horticulture Hotline
Have questions about trees, lawn, garden? Want to know how to test your soil? Every found an ... appointment throughout the year. The Hotline is staffed by Master Gardenered Volunteers. email: ...
Sesquicentennial Scholars making waves
Leadership Program, thirteen are currently enrolled in the College of Food, Agricultural, and Environmental ... Meet the Sesquicentennial Scholars from CFAES below: Chris Baird- Agricultural Systems Management ... College of Food, Agricultural, and Environmental Sciences. I knew the university could provide me with ...
Alumni in the news
Agricultural, and Environmental Sciences: Ronald Beckham BS Horticulture 1955- Ronald C. Beckham Brad ... Bergefurd BS Horticulture 1990, MS Agricultural Education 2011- Attendees to go from bines to steins at Ohio ... Hop Conference Dr. Kris Boone MS Agricultural Education 1991, PhD Agricultural Education 1994- ...
Plant Empowerment Workshop
physiology, leading to a balanced growing method for high yields, quality, saving energy, and profitability in ... in Hilton Garden Inn Columbus-University Area, 3232 Olentangy River Road, Columbus, Ohio, 43202. ... plant physiology that leads to a balanced growth of protected crops and results in healthy resilient ...
Undergraduate Research
research with faculty located in Columbus and at the Ohio Agricultural Research and Development Center in ...
Animal Sciences Alumni In The News
Advancement: Gary Bauer BS Animal Science 1966, MS Agricultural Education 1973- Piney Paradise: A Family ... 2011, MPHM Plant Health Management 2014- Late Planting Leads to Wetter Harvested Grain Hannah Jarvis ... Agricultural Education 1997- Chow Line: Growing Giant Pumpkins Dr. William Fling BS Animal Science 1971- Dr. ...
2020 American Angus Association Internship
communications intern will truly gain valuable agricultural communications experience. Applicants should have ... Show (NJAS), Leaders Engaged in Angus Development (LEAD) Conference and other events is expected. AGI: ...
CFAES names its inaugural Distinguished Professors
The Ohio State University College of Food, Agricultural, and Environmental Sciences (CFAES) has ... announced four inaugural Distinguished Professors of Food, Agricultural, and Environmental Sciences. The ...
CFAES Buckeyes celebrate worldwide
We're celebrating 150 years of The Ohio State University, formerly the Ohio Agricultural and ... Mechanical College, and the College of Food, Agricultural, and Environmental Sciences (CFAES). We invite ...


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Ken Sleight was an old river runner/desert rat who was the inspiration for Ed Abbey's character "Seldom Seen Smith" in The Monkey Wrench Gang."
I like that he calls Lake Powell "Lake Foul."
"It was probably foolish and masochistic of me to have hung around and watched it happen. But I just had to. At first it would rise a foot overnight, and you saw things you loved go under. First it was Music Temple. Then it was Gregory Natural Bridge. Then Cathedral in the Desert. I'd think of those fools that said this was a good thing, that we needed this dam. Then I'd see Hidden Passage or some other lovely spot with no name go under…it was unbearable.
"And I'll always remember the sign at Rainbow Bridge. There was a Park Service sign along the trail and it read: 'God's Work. Tread Lightly.' The next week, the lake came up and buried the sign and the trail." By late 1964, the reservoir had reached Hite and Glen Canyon was gone…for now."
Here are historical data on the levels at "Lake Foul," among other things…U.S. Bureau of Reclamation
Martin Litton was an uncompromising conservationist of the West, and another legendary foe of the Glen Canyon dam.
He was the movement's Jeremiah — the crier in the wilderness who spotted the threats, condemned the desecraters and rallied the leadership to the defining preservation conflicts of the early 1950s through the '80s.
David Brower, who as the Sierra Club's seminal leader in the last half of the 20th century was compelled to make some of the compromises Mr. Litton fought, was known to call him "our conscience."
–New York Times
I discovered his obituaries in the regional media websites (Trans-Pecos Texas, Southern New Mexico) when I was looking for info for the NPS ranger I'd met way back in my earliest trip to Dog Canyon in Guadalupe Mountains National Park.
(I include the NPS page here, but I've also captured the page to a PDF if the park service changes the link in the future.)
I'll start from way back when. Continue reading Roger Reisch-GUMO NP
[Original date August 31, 1997]
Trip report from a hike to the summit of Wheeler Peak, the highest point in New Mexico (13,161′) undertaken August 31, 1997.
Wheeler Peak is the highest point in New Mexico at 13,161′. The hike to the summit via Bull of the Woods is about 15 miles round trip, and has an elevation gain from 9,000 to 13,161′. This climb is non-technical during most of the summer. But extreme care should be taken during the thunderstorm season-July and August-since much of the Wheeler Peak trail is above timberline and exposed. Getting to and off the summit before thunderstorms this time of year will entail a near-dawn departure.
This page has some good advice on and descriptions of ways to attach gear on the outside of your backpack. Sectionhiker.com
The "History of Gear Project" site is remarkable!
This guy has, crudely in some respects, patched together an interesting series of pages and links on the historical roots of most backcountry gear and gear companies today. A lot of this information is not easily found even with today's wide-reaching search algorithms.
From the origins of companies like Sierra Designs, legendary Berkeley-based Ski Hut, little-known Oregon outfits…if you have any interest at all in how what you carry on your back came to be you'll be engrossed in these pages.
Here are some of the tents I've used:
First tent I ever owned started out as a loaner from a friend of Dad's.Continue reading Tents
Big Bend Ranch State Park is a huge state park just west of Big Bend National Park.
I completed a North to South thru-hike of the John Muir Trail in 2002. Here is a trip report of my hike.
John Muir Trail day 1 – 3 Continue reading John Muir Trail Thru-hike 2002


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Effective Ways Of Choosing An Orthodontist For Beautiful Smiles
The market in general has a wide variety of orthodontists that one can choose from when in need. There are a lot of inventions in the field including invsalign and even though not all the orthodontists have incorporated all these into their practice, a lot of them are good at what they do. It is wise to consider a number of key factors when in the market for one because choosing the best one for your needs can be quite a tough call. Find below some key factors to consider when choosing an orthodontist.
Begin by doing some research to learn a lot more reading those found near you. Inquire about the services they offer. Find out if the orthodontist is conversant with invisalign and if he or she carries clear braces in their stock in line with that. Visit the websites and see what more you can learn about their services. This included the reading of the reviews from others that have used their services before.
The costs of the services is also another important thing to look at. Ask about the prices charged for the services you need. The best way would of course be to do an actual consult with the orthodontist so that he or she can advise the stages and costs. Find out if the orthodontist takes insurance cards so that you can have your insurance cover some of the costs.
Technology is very important when it comes to orthodontics, ensure that the doctor is up to date. They should be using digital records and also have digital x-rays. Many people avoid getting braces because of the look but there are invisaligns which get rid of the problem, make sure that this orthodontist has these. You will find that the best orthodontists will make sure that the care they give to their patients is the very best by doing research and making sure that they are updated all the time.
Don't forget to look into the reputation of this particular orthodontist. The best way to know how good the orthodontist's care is, is to consider the satisfaction of the patients. The result of the treatment should be beautiful smiles and if this doesn't happen for his patients, look for another orthodontist. The best part about choosing a reputable orthodontist is the fact that they cannot afford to lose their good name.
Find an orthodontist who has his own clinic. You will need to go for routine adjustments, you should know where to go and be assured to find the doctor there. How busy is the orthodontic clinic on a normal day? Having many patients might be a good sign showing that he has good services but it might also be a problem. On the negative side, this might mean long queues.
Orthodontic care is for more than just having a beautiful smile. Crooked teeth affect your gums which might cause issues.
Getting Creative With Dental Advice


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Did you know that the skin is the bodies largest organ? Well you do now and you also have a nugget of information you may be able to use in a pub quiz or on Christmas day during post lunch family games…
As well as being a huge organ, it's also amazing at detecting vitamin deficiency. You can use vitamins to supplement these naturally, which would always be my first choice.
Here are some more "nuggets" you may find useful in determining what's actually causing some of these common problems and how to try and remedy them. Of course, you can get these vitamins from your food but it may not be quite the quantity you need to improve the conditions.
- Dandruff – try a zinc supplement
- Psoriasis – vitamin D
- Acne – zinc and vitamin C
- Eczema – probiotics and good fats
- Dry skin -vitamin A, C and try increasing your water intake
- Bumps on arms- vitamin A and zinc and often indicates an intolerance to gluten
- Dermatitis -vitamin B6 & B3
- Coldsores – Vitamin E, B6 & B3
- Ageing skin – COQ10, vitamin E & C


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Children of ankylosing spondylitis systemic symptom
อาการของเด็กที่เป็นโรคข้อสันหลังอักเสบยึดติด ankylosing spondylitis
high fever symptoms are phases.Chronic disease for low heat usually takes the symptoms, significant weight loss, the whole body is fatigue, muscle atrophy, many local with serious peripheral large joints, and joint axis, hip osteoarthritis symptoms in most see more.A few children have lymph node enlargement, mild or severe anemia.
happened only history of repeated episodes of iris inflammation, can last for years, early iris inflammation can be ankylosing spondylitis only performance, performance for unilateral jealous, pain, photophobia, and black Meng etc, can have eyes, involving heavy appear alternately, duration is commonly 4-6 weeks, iris inflammation usually without sequelae.
serious aortic valve closed not all were rare, individual ankylosing spondylitis have nonspecific block lesions.
spread the chest rib joint affect respiratory function.No serious patients with spinal involvement, the general effect of thoracic range of motion and breathe without change.
and onset form: the disease in older children, male more than female, men and women ratio is about 80%-90% of cases now, other than weeks joint, or as the main symptoms of infection attachment points and general with lower limb is given priority to, have lower back pain, morning stiffness, activities such as the limited symptoms or X-ray sacrocoxitis.Affected joint usually less than 10, few joint see more than many joints, often for one or not symmetrical.
peripheral arthritis: the performance for the single arthritis, few arthritis or attachment point inflammation, sustainable or repeated attacks months and years.More than 85% lower limb joints involved, upper limbs arthritis rare, few arthritis is usually unilateral or asymmetry, many joint general symmetry, for often misdiagnosed for rheumatoid arthritis. And the following disease identification:(1) children ankylosing spondylitis and children of rheumatoid arthritis identify: children of ankylosing spondylitis early clinical performance often meet children of rheumatoid arthritis diagnosis standard. But ankylosing spondylitis always have a positive family history, HLA-B27 positive, arthritis, joint hands with lower limbs as less involvement.We experience, and close examination double sacroiliac joints, such as tenderness, 4 words experiment and often the positive results; Attachment points for both the best identify disease, especially in full, knee weeks the place such as the involvement more meaningful.If three or five years appear joint axis performance, it is not difficult to diagnosis general.
the genetic differences: children of ankylosing spondylitis often SC42 single times type and G1o-1 b dialdehyd enzyme and adult-onset phenotype, a single times for SC31 type and G1o-2 b dialdehyd enzyme phenotype.2, clinical differences: children of ankylosing spondylitis, including sufficient with peripheral joints involved more;And the adult-onset including cervical, thoracic vertebra, square change, and vertebral bone bridge and bone into the joint axis involvement at more see. Children of ankylosing spondylitis sustained or repeated attacks of hip, knee, ankle and between toes arthritis is adult see more, need to do more also hip replacement. In addition, fever, anemia, such as interleukin increased is also see more children.
do not easily identify diagnostic rheumatoid arthritis.
This article from:Disease knowledge


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Of Enduring beyond the first time
The first time is always the hardest. And, if its not, then you are lucky. Or maybe, you are just not cursed. Maybe, its not your destiny to keep reeling with myriad doubts and an insufferable anxiety until the deed takes shape. Maybe, you get by just fine each time. Maybe, you are never consumed by the maddening throes of the madman syndrome where reality is jaded and jabbed by an ultimate kind of angst and restlessness. Maybe, the first time is never hard for you, and maybe, you are never overwhelmed or struck by a subtle frenzy that leads you to chew on your nails or bite on your lips or to hyperventilate. But if you are someone like me, you would know the mind is a strange river and the current of reality is turbulent and puzzling. And, that the first time is indeed the hardest and scariest.
Have you ever noticed the jarring discrepancy between how the mind perceives for the first time, and how it gradually shifts gear, and transforms the new into the old? How the mind confronts that which is unfamiliar, and that which is vastly known? Are you able to observe your mind as it constructs the elaborate labyrinth of feelings, emotions and thoughts? Are you able to grasp and marvel at the way the mind narrates the story of reality? Not until recently, did I gasp at the surreal yet very real disposition of the mind to alter continuously the landscape of reality. What do I mean? Here's what I mean.
Things look different and feel different the first time. There is no sense of attachment, but a ruthless analysis: an organism that has evolved over millions of years scopes out the territory, and sorts through the sensory inputs to get a perspective on the place. There is a certain sense of detachment, of disconnect: the mind hasn't yet warmed up, and opened up to that which it encounters. Simply put, the mind hasn't placed its trust, and hasn't lowered its guard. Like our earliest ancestors moving to a new Savannah and scanning the horizon for threats, our minds explore the realm of a new experience or a new place with skepticism and a sharp alertness. The mind is wound up in anticipations, and experiencing the present. There is a certain edge.
And, as you keep at the place and the experience, day in and day out, the mind begins the next phase: adaption. It assimilates and incorporates that which it deals with repeatedly into our nervous system. It builds associations and connections, references and memories, emotions and thoughts, experiences and ideals. It idolizes or demonizes, loves or abhors, and often idolizes and demonizes, loves and abhors at the same time. Soon, the thing that is new becomes a comfort zone. A thing that the mind has relegated as harmless, and soothing. The edge has worn off. Mostly.
As I drove down streets that were completely new to me, and stayed in hotels in cities that I hadn't been to before, and had experiences that I hadn't had before, I noticed how my mind sighed, and grappled with anxiety, uncertainty and skepticism, but after having persisted, the mind classified the same permutations and combinations of experiences into comforting, non-threatening and counter-productive categories.
Many times, that elusive knowledge and all consuming suspense of whether we can pull off what we are about to do leaves us mired in anxiety and discomfort. Like a child imagining monsters under the bed, the mind can leave you stranded in a minefield of imagined terrors. And, the only way to beat that is to take the very first step, and let it lead you to a new kind of reality, which the mind will get to if you persist and endure. Because that is the nature of mind: it adapts, it builds and it destroys, in short it animates the circle of life.
September 2017


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Illinois charter public schools are seeking to hire talented teachers, teacher leaders, social workers, counselors, nurses, administrators and many other roles.
Please click "Job Seeker Registration" to join the INCS Online Resume Bank and share your professional profile and resume with charter school hiring managers year-round.
Illinois charter public school hiring managers may click on "School Hiring Manager Registration" to join Resume Bank and search for candidates.
Job Seeker Tips and Resources:
Joining Resume Bank allows charter recruiters to find you. We strongly recommend that you also research current charter openings and apply directly with the schools.
Job Seeker Resources:
About Charter Schools:
Charter schools are free, independent neighborhood public schools open to all children, including students who are English language learners and students with special needs. Charter schools do not have special entrance requirements and have the freedom to be innovative, while being held accountable for advancing student achievement.
Each charter public school is unique – both inside and out. Some may focus on college preparation, math and science, and others integrate the arts into each subject. While the possibilities are endless, charter public schools aim to provide a range of options so that parents can choose the school that best fits their child's needs.
Likewise, educators can choose to work for charters with missions, educational approaches and professional cultures aligned to their own beliefs and work styles. Visit www.incschools.org to learn more about charter public schools.
The Illinois Network of Charter Schools (INCS) hosted its 14th annual Teacher & Administrator Job Fair Saturday, April 6. Representatives from charter public schools across the state attended to recruit high-quality talent to fill their job vacancies, including teaching, school leadership, social work, and administrative positions. Hundreds of job seekers attended the event.
Candidates and school leaders mingled during the meet and greet portion of the job fair. Dozens of candidates also interviewed with prospective employers on-site.
Valerie Butron said she was glad she attended the INCS job fair. "I had great conversations and am excited about the opportunities that I learned about today," she remarked. "I would recommend the fair to anyone looking to explore a career in charter schools in Illinois." "
Teresa Jarrett, another job seeker, gave the fair a "10 out of 10 rating," saying she would highly recommend it to others. "The school leaders were engaging, and I met with representatives who truly care about kids and their educational experiences."
INCS would like to thank ITW David Speer Academy, a campus of the Noble Network of Charter Schools, our sponsors, Charter Substitute Teacher Network, Hallagan Business Machines, Holberg Financial, our official recruitment partners, Bradley University Smith Career Center, DePaul University College of Education, Northwestern University Master of Science in Education, Saint Xavier University College of Art and Sciences: Education and Western Governors University Career and Professional Development Center, and the many other colleges and universities and partner organizations who assisted with outreach to job seekers for helping to make this event a success!
ABOUT INCS: The Illinois Network of Charter Schools (INCS) advocates for the improvement of public education by leveraging the charter school model as a catalyst to transform lives and communities. INCS works to ensure that charter public schools have adequate and equitable resources, the autonomy to find innovative approaches to meet student needs, and a fair and transparent policy landscape that allows high-quality options to thrive. As the voice of Illinois charter schools, INCS engages a diverse coalition of policymakers, school leaders, parents, and community members to create systemic change and secure high-quality schools for underserved communities. Learn more about us here.


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Created By: Pulaski County Tourism Bureau & Visitors Center
The Roubidoux is known as the "hidden gem" for trophy trout fishing, offering up red and white ribbon areas and regularly stocked by the Missouri Conversvation Department. Take you fresh catch to local restaurants to be prepared and served while enjoying a glass of Missouri wine.
Photo courtesy of Sam Potter, Roubidoux Fly Fishers Association
This point of interest is part of the tour: Must Stop's In Waynesville
Please send change requests to firstname.lastname@example.com.


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Are Your Clients Eternally Under Your Control?
Do Your Clients Become Your "Hypno-Slaves"?
Learn How Your Clients Are Always Either Choosing To Opt In or Opt Out
Hypno-slaves? Really? Some folks out there think that if their hypnotist hypnotizes them, even once, then they must do everything that is suggested by that hypnotist forever!
Of course that is far from true. Your clients are either choosing to work with you and follow your suggestions or they are opting out of the process. Any hypnotist who has seen almost any number of clients knows that clients can become non-compliant, uncooperative or even reject certain suggestions.
- Click to be Notified of New Hypnosis Training Videos Like this One.
- Click to Play Audio-Only Version
- Click to See Upcoming Course Schedule
In this hypnosis training video we reveal how you can help clients to opt into the hypnotherapy process while at the same time understanding that they have the ability to stop the session at any time. Most adults realize this and others seem to need to have this idea reinforced.
Of course we are going to the NGH convention! We recognize that you, the viewers of these videos are some of the most motivated and professional hypnotists in our profession. With that in mind, we want to strongly encourage you to start making plans to go to this convention, it is the 65th Anniversary of the National Guild of Hypnotists so you know that it is going to be great. Not convinced yet? Watch this video and you will find out why going is a "no brainer".
One more thing – Remember to check our course schedule for our Hypnosis & Hypnotherapy Certification Super Course and special upcoming NLP Basic Certification taught by Dr. William Horton. Check for early registration discounts.
Like our videos? Then remember to get instant access to all my free videos by becoming a VIP member of the site. It's free.
Let's do GREAT things together!
Cal Banyan
PS… More Important Links & Info:
July, 2015 my NGH Approved Banyan Hypnosis / Hypnotherapy Certification Super Course is filling up! Remember to check out my upcoming class schedule here on this site to see when my next classes are and see if you can get in on the early registration discounts. Then I'll see you in class. Check later courses for early registration discounts.
SAVE $575 on NLP with early registration. Dr. William Horton is coming to the Banyan Hypnosis Center to teach the "Ultimate" Basic NLP Course, and I'm taking the course! Let's get certified in NLP together! Get in on the early registration discount! The date for the course is June 19 – 22, 2015. Get all the info. and get your seat! Be a more effective and successful hypnotist!
I want to see you in class! Make sure you check out our upcoming courses and get in on any early registration discounts that apply! Early registration discounts don't last forever. Get world class training onsite in our classroom or participate live online from your home or office!
FREE INSTANT ACCESS TO ALL OUR HYPNOSIS, ETC. VIDEOS Get a super easy linked list of all Hypnosis, Etc. training videos! VIP Membership is free – Click Now!
Become a member of www.OurHypnoSpace.com! It's free and fun professional networking! Use the "Ask Cal" Group on www.OurHypnospace.com to ask questions and suggest topic ideas for the Hypnosis, Etc. show!
Do you "like" our videos? "Fan" us on our Facebook page at www.Facebook.com/hypnosisetcGet in on the conversation and we place more "hypno-gold" there on a regular basis. Share us with your hypno-friends! Thanks!


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The Florence Residences Developer
Founded in 1996, Logan Property Holdings Company Limited ("Logan Property" or "the Group", stock code:3380.HK) is an integrated property developer focusing on residential property development in the PRC, mainly the Guangdong-Hong Kong-Macao Greater Bay Area, with its products primarily target first-time homebuyers and upgraders. It was listed on the main board of the Stock Exchange of Hong Kong in 2013.
The Group has Grade-A qualifications in property development, general contracting of construction as well as engineering design, and is one of the best property developers in the PRC in terms of overall strength. In 2017, the group jumped to 295th in Fortune China's Top 500 Enterprises. In 2018, the Group was ranked 26th in the China Top 100 Real Estate Developers and 4th in the Top 10 Most Profitable Companies, with its brand and overall strength being highly recognized by the market.
Adhering to the business concept of "Building a Better Life", Logan Property has so far developed over 150 residential projects and provided quality life services to over 600,000 people. The Group has been focusing its business in the Pearl River Delta, Guangdong and Guangxi in China, and has had the foresight to build a footprint in the world-class agglomeration Guangdong-Hong Kong-Macao Greater Bay Area, which is part of the national strategy. Over 80% of Logan Property's land bank is situated in the Guangdong-Hong Kong-Macao Greater Bay Area, such provides a solid basis for realizing future growth. The Group started to expand its business to overseas markets in 2017. It commences its international journey of expansion by acquiring quality projects in Hong Kong and Singapore.
On the back of an excellent performance and outstanding comprehensive strength, the shares of Logan Property are constituent stocks of Hang Seng Composite Large Cap & Medium Cap Index, MSCI China All Shares Index and FTSE Shariah Global Equity Index and are included in the list of eligible stocks for Southbound trading under Shenzhen-Hong Kong Stock Connect and Shanghai-Hong Kong Stock Connect. In addition, the Group is rated Ba3, BB- and BB- by Moody's, Standard & Poor's and Fitch, respectively, with a stable outlook.
Looking forward, Logan Property will continue to focus its business in the Guangdong-Hong Kong-Macao Greater Bay Area and will push forward with its steady business expansion, so as to create greater value for its shareholders and customers.
Act Now To Secure Your Future
With so much going for it, The Florence Residences will be in high demand. Initial indications already show extremely strong public interest for the units available. Contact us today for more details and to stay up to date with the latest news, pricing and developments.


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Du-Ha Tote
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Du Ha Parts
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Du-Ha FAQ's
Contact Us
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Who We Are
We love restaurants as
much as you do. Restaurant.com has arrangements with
thousands of restaurants across the USA and we've been
helping them fill tables since 1999. Whether you're
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experience. Your new favorite restaurant is out there –
go ahead, dig in!
What we do
The first step
to redeeming the gift card code is to go online to
http://Dine.Restaurant.com, enter your Gift
Certificate number along with the verification text from
the image on the screen and click "Redeem Certificate".
(A mobile app is available from
Enter your ZIP Code and a handy list of restaurants'
near you can be found. Restaurant.com's Verified Diner
Ratings and Reviews will help you along the way with
reviews of diners who have eaten at the restaurant, so
you know that pizza passed the test and the tiramisu was
truly terrific.
Once you've discovered the perfect restaurant, it's time
to redeem your certificate. From the restaurant of your
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What happens if I lose my certificate number?
Please treat the Gift Code as cash. It can't be replaced
if lost.


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Below I wrote about my love of turquoise and my love of mid-century modern design. Here is a home that is just too good to pass up. Beautiful mid-century design, beautiful wood pieces and great use of turquoise pops.
For the rest of this beautiful home see Kristen and Mike's Mid-Century Oasis via Apartment Therapy.


text: Home / New Nile Backpack Cote & Ciel New Nile Backpack in Obsidian €305.00 (€252.07 For non-EU shipping destinations) Sold Out Availability: Out of stock Get notified when this product is back in stock. Description Sizing Delivery & Returns Brand The Nile Rucksack Obsidian by Côte & Ciel is based on the brand's iconic Isar Rucksack. It's design is a complex interplay between form, space and practicality. It features a back compartment with mesh pockets, two top compression straps and a padded laptop pocket that protects 15" devices. The rucksack has two padded and adjustable carrying straps and a concealed hood to protect the wearer from severe weather conditions. It comes in Obsidian Black. Côte & Ciel Nile Rucksack in Obsidian Black Modern Design Made out of Polyester Two padded and adjustable shoulder straps Two top compression straps Back compartment with padded laptop pocket and mesh pockets Concealed Hood There is no sizeguide available for this product. Delivery All our orders are shipped including tracking by our partner PostNL, the national shipping company. Orders placed Monday through Friday before 16:00 GMT+1 are shipped out the same day. View all shipping information and rates Returns & Exchanges If for any reason you are not happy with your purchase, you may return the item(s) within 90 calendar days starting the moment that you received your order. Orders returned within 14 days after you've received your order are eligible for a full refund. Orders returned after this period are refunded as a store credit. Items on sale can only be returned within the 14 day period and do not apply for a store credit. View all exchange information Chat with us!


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March 26, 2018 –
"So Stormy says she and Trump had sex only once.
I guess if you want the guy to screw you repeatedly,
you have to be one of his voters."
What do you think? Is "Ann Coulter on Stormy Daniels and Donald Trump" Funny or Offensive? VOTE and COMMENT now…
Share this article


text: TV / Video Donald Trump and Hillary Clinton Have Been Spending the Most Money on These Ads His late surge of daily national spend tops $1 million By Jason Lynch|November 2, 2016 Share By Jason Lynch|November 2, 2016 Share As the presidential race enters its final week, Hillary Clinton has been dominating the national ad spend, but Donald Trump is making up for lost time with a late, pricey surge, topping $1 million a day. According to data from iSpot.tv, which tracked national campaign spending from Oct. 18 to Oct. 30, Clinton outspent Trump nationally by $2.1 million, and her national spots aired almost two and a half times as often as Trump's did. In that two week period, Trump spent $7.8 million on national TV advertising, running 10 ads a total of 926 times. Clinton spent $9.9 million during that span, running 12 ads a total of 2,397 times. iSpot.tv's data does not include local ad spending, where both candidates are flooding markets in battleground states like Florida and Ohio. During those two weeks, Trump's ads appeared on TV screens 491 million times nationally, and had an average view rate of 91.8 percent (meaning 91.8 percent of each ad was actually watched, on average). Clinton's ads appeared on TV screens 620.6 million times nationally with an average view rate of 85.8 percent. It's not surprising that Clinton's view rate is lower, given that she is running more national ads than Trump and audiences have had more exposure to her spots, and are therefore paying less attention to them. Trump is focusing on bigger audiences, with 20 percent of his spending coming during prime-time hours. Clinton has dedicated 16 percent of her national ad budget to prime time, but she has spread her ads across more networks and dayparts, especially daytime and early fringe. The iSpot.tv data shows that Trump has been making a late surge in national buys, spending more than $1 million per day beginning Oct. 26. According to iSpot.tv, Trump's national ads aired most frequently on Fox, CBS, NBC, ESPN and CNN. He's targeting major broadcasts like the NFL, the World Series, college football, The Voice and The Late Show with Stephen Colbert. Clinton, meanwhile, has been focusing on CBS, TNT, NBC, FX and A&E. Like Trump, she also has run national ads during The Late Show with Stephen Colbert, but she's also targeted NBA basketball, Today, Jimmy Kimmel Live and American Horror Story: Roanoke. Trump's biggest spend day is Sunday (NFL day), with $2.1 million spent on the last two Sundays, while Clinton peaks with Wednesday—when American Horror Story airs—with $2.0 million spent over those two Wednesdays. During that time, Trump's most aired, and most watched, national ad was "Change," which launched on Oct. 18 and focuses on Clinton's inability to enact meaningful change during her many decades in D.C. It aired 411 times and received 232 million national impressions. It had an estimated national spend of $4.9 million and a 85.3 percent view rate. The Trump ad with the highest national view rate is "Laura," which also came out on Oct. 18 and focuses on a mother whose sons was murdered by an "illegal alien." That spot had 44 million impressions and an average view rate of 98.3 percent. Clinton's campaign spent the most on its "Silo" ad, in which a former missile launch officer talked about his fear of Trump controlling the launch codes. That spot, which came out on Oct. 1, had 110 million national linear impressions on a $2.1 million spend. It had a 82.6 percent view rate. But Clinton's most viewed ad during that time period was "Measure," which focused on improving the lives of American children. It launched on Oct. 6 and had 121 million impressions on a $1.7 million spend. She had the highest average view rate for "Barbershop," which came out on Oct. 24, and featured African-Americans at a barbershop talking about Clinton, tying her to President Obama. The spot earned a 99.3 percent view rate with 3.8 million national impressions. Clinton's national ads are reaching more women (53 percent of the audience for her ads is female), while the gender split from Trump's ads is an even 50-50. Trump's national ads have been reaching an older audience than Clinton's spots. The demo breakdown of the audience for Trump's ads is 26.8 percent adults 18-34, 35.8 percent people 35-54 and 37.4 percent people over 55 years old. Clinton is reaching 28.0 percent adults 18-34, 36.2 percent people 35-54 and 35.8 percent people over 55. Share http://adweek.it/2fvK9dt copy Adweek Adweek


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This event has passed.
SwimShowJuly 16 to 19, 2016 - Miami Beach, Florida, USA
SwimShow is the the largest and most significant swimwear tradeshow in the world.
The annual SwimShow is an essential show for the industry—a platform for building relationships, enjoying the latest trends in swimwear, and connecting buyers and suppliers. Recognized as the launching pad for many of the industry's leading lines, SwimShow is hosted in Miami Beach, the swim fashion capital of the world!
SwimShow welcomes exhibitors and buyers from all around the world to join in this one-of-a-kind tradeshow that showcases more than 2,500 of the very best curated lines.
The show draws more than 3,000 buyers from 60 different countries spanning the globe. It is the largest swimwear tradeshow in the world and the first opportunity for buyers to see the latest designs for the upcoming cruise season.
With more than three decades of the SwimShow expertise, The Swimwear Association of Florida is recognized as the leader in swimwear exhibitions worldwide. As the industry's most celebrated and established exhibition, the SwimShow is the premier global tradeshow where the best of the best gather to network, exhibit and purchase next year's trends.
Held every July, the SwimShow is the largest of its kind in the world and attracts more than 7,500 brands and buyers from 60 countries across the world. This year's show offers more women's swimwear than ever, including expanded men's and children's swimwear collections, resort & lifestyle and accessories for all occasions. Collections cater to designer boutiques, resort shops, specialty stores, surf shops, department stores, mass merchants and more.


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Posted in Indiana April 24, 2018
You'll Have Loads Of Fun At This Pirate-Themed Restaurant In Indiana
Indiana has no shortage of restaurants offering tasty fare, and you can never go wrong with the tangy, sweet goodness of bbq. Here's a restaurant that not only serves up delicious bbq meals, but it also has a quirky, fun pirate theme.
Have you dined at Big Hoffa's BBQ? Tell us about your meal!
If you're looking for more unique dining in Indiana, give this lakeside cabin restaurant a try!


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Woodpecker is the premium cottage at Yare View Holiday Cottages, boasting fantastic, panoramic views of the river, marina and surrounding landscape, its own private river front garden and spacious hot tub terrace.
Fully refurbished for 2017, Woodpecker has undergone a 5-Star makeover with a stylish, contemporary new kitchen and a stunning, elegant bathroom suite. Woodpecker has been attractively furnished with an open plan, modern feel, to provide ultimate comfort and convenience, for the perfect Broads holiday experience.
This cottage offers an exquisite open plan kitchen, dining and lounge areas, very comfortable for up to 5 people.
The kitchen comes equipped with a hob, oven, microwave/oven, large fridge/freezer, dishwasher and washer/dryer. Smaller appliances include a toaster, kettle, coffee maker and a great range of cookware, utensils as well as cutlery and crockery.
The dining and living rooms have been handsomely furnished and enjoy stunning, southern and western views. The living room has a 42" Smart TV, with Netflix, Bluetooth Radio/Speaker and with dimmable lighting throughout to really set the mood.
The magnificent, spacious bathroom has been designed with a luxurious walk-in shower and 'his and hers' wash basins. Woodpecker is a 3-bedroom cottage. The master bedroom is on the ground floor with a double and single room upstairs.
The downstairs master bedroom includes an impressive, upholstered king size bed (150 x 198 cm), wardrobe, flat screen TV and French doors leading out to the hot tub terrace overlooking the river.
At the top of the stairs, there is a small balcony to enjoy an elevated view of the river.
The double room includes an upholstered double bed (137 x 190 cm), chest of drawers, clothing rail and another small balcony supplying picturesque views of the whole river.
The single room also includes an upholstered single bed (90 x 190 cm), clothes rail and chest drawers.
The spacious terrace includes a large hot tub and an alfresco dining area. The terrace is neatly screened to provide privacy but also allows views of the river and Broads landscape. The small, enclosed garden area is located next to the river on the southern side of the cottage, enjoying the sunshine all day long…a great place to watch the boats and wildlife float by.


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The So Then Collection - Jazz
I Love This CD! ...You make the Call.
Hear it and Buy now at: http://www.cdbaby.com
This wonderful CD features: My brother Melton Mustafa on trumpet Silvano Monasterious on piano, Paul Shewchuk on bass, James Cotmon on drums, and Johnny "O" Onderlinde on congas (It's Better Than Cool.)


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We loved Sydney native (currently Berlin-based) singer songwriter James Chatburn's track 'Holiday Love' so much that it went straight into the 'Best Of 2015' file on its release back in February.
But one listen to his new single 'Creator' (below) and you'll soon discover this young man is no one-trick-pony.
'Creator' is the third in a series of four tracks to be released across the course of 2015, with 'Cracks And Breaks' the final song of the series to follow in November.
It's gorgeous, neo-soul. James' vocals are rich and caramely, oozing with warmth and style. The production too is smooth, sexy and utterly swoonsome.
Mark our words… James Chatburn is on track for superstar status.


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Save Me, Season 1
- $14.99
- $14.99
Emmy nominee Anne Heche ("Hung") stars as Beth Harper in NBC's new comedy about a not so ordinary Midwestern family. After choking on a hero sandwich in her kitchen and suffering a dramatic near-death experience, Beth, an absentee wife & mother, is revived and claims she can now talk to God. Her teenage daughter Emily (Madison Davenport, "Shameless") is horrified and her husband Tom (Michael Landes, "Final Destination 2") is skeptical. To make matters worse, Tom's ex-mistress Carly McKenna (Alexandra Breckenridge, "American Horror Story") is in a coma after a close encounter with lightening in the Harper's front yard. As Beth warms up to her new life, she strives to make amends to the people she has alienated over the years, including her friends and neighbors Jenna Dennings (Heather Burns, "Bored to Death") and Maggie Tompkins (Joy Osmanski, "It's Always Sunny in Philadelphia). Despite everyone's initial hesitancy, Beth begins to win people over with her new positive attitude, cheerful optimism and unbridled love.


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Since its first release, Ghost - an open source publishing platform - has come a long way. It has immediately gained popularity because it's easy of use and simplicity. Since then, lot of new features have been added to it, and the platform became a lot more robust: it's very easy to manage it via it's CLI, it's easy to create customisations using its amazing API, and there's a myriad of new features that are added in each release and that are being actively worked on.
Being one of the earlier adopters of Ghost I have immediately fallen in love with it and have used it to launch a few blogs of my own - including this very blog that you're reading at the moment.
There's one feature of this otherwise great platform missing in my honest opinion. Image management. Don't get me wrong, Ghost can handle images but it's rather basic, and it's not feasible if we want to keep a blog that performs well (i.e., loads fast). And if you don't take my word for it, you can see a lot of discussion on this topic on the Ghost Forum.
Image management in Ghost
So what does Ghost do at the moment regarding image management? Using the new Koenig editor (before it was only Markdown) we can add images as well as image galleries to blog posts (plus a great number of other things, please refer to the link before) and the upload of the image assets are also handled by Ghost. The images get uploaded to the server and served directly from the filesystem. The code behind the displaying implementation looks like this:

Some caption

figure element is used in conjunction with the
img element to display the image, and by default, the upload folder is the root of the Ghost blog followed by
/content/images/ and a year and month folder.
As mentioned before using such image management is easy, and very straightforward and at least using this new editor some basic operations on images like uploading is handled.
Concerns regarding the current solution
However, there are a few concerns regarding this approach, and there's a lot more that could be done. There are a lot of companies that have started to use Ghost as their publishing platform and some heavily use media such as images - engineering blogs, including Mozilla's VR Blog, Tinder and DuckGoGo all use Ghost. (You can take a look at some of Ghost's Customers.)
Let's walk through an example and see an interesting issue with Ghost's current image management solution. The basic premise here is that we'd like to avoid having to edit an image before uploading it to Ghost and using it in a blog post - some people may not have the necessary skills (Photoshop) anyway to do exhaustive image manipulation.
The test setup
To run a few tests, I had setup Ghost locally and added two articles with the same content. Each article has a cover image, two large photos displayed in the manner discussed earlier plus an image gallery was also added to the article.
A typical use case
Let's consider a travel blogger or even a travel magazine wishing to use Ghost. Such a blog is by default going to be very visual, sharing a lot of images were snapped during the travel and therefore creating a visual experience that would, in turn, get more people visiting the site. A very simple idea which should be created using Ghost very easily.
Now, of course, this is only a sample blog article, and there's not much text, but there are nine images displayed on the page. We have to assume that our blogger in question does what the majority of people would do: take photos on a mobile device and use the Ghost editor to add them to the article. This has quite a few bad repercussions:
- when displayed, the image will be scaled down using CSS only
- the picture is not going to consider the browser and always be presented in a given format (e.g. JPG)
Even before running any tests we can use the Chrome DevTools to check that the images are scaled down either via CSS or by the browser itself:
What happens is that we load an image that's 2000 x 2667 pixels into a space that can hold only 840 x 1120 pixels. This also means that we are downloading the entire image which is about 615 KB in size. That again is not the best thing to do. In fact, the size of the image served is the same size on the filesystem after the upload:
Note that the Koenig editor in Ghost can display the image in its original size or resize it as we saw it in the example. The raw image is 2.5 MB in size. We are using a scaled version, but that's still not optimal.
Please also note that if, on the same day the same image is uploaded Ghost will keep a copy of both pictures taking up disk space in the same folder. (Ghost appends the filename with -[x] where [x] is an integer). In fact, the same image could be uploaded every day and be placed in the appropriate folder creating massive redundancy.
Let's run the site through a Website Speed Test tool that will take a look at all the media on the site and offer some recommendations.
We can see from the above that we got a "Mediocre" C score, which is not great. 11 images got analysed on our page, and just these 11 images contribute to 6MB of the site. That's quite a lot considering we "only" have 11 images.
Let's take a look at an optimised version of the site as well as discuss how the was optimisation done.
Each image has been uploaded in its raw format to Cloudinary, and it's being served from there via URLs that also make the following changes:
- reduce the quality of the image without impacting the visuals to the human eye
- serve the right type of file per each browser (e.g. WebP for Chrome)
- apply the right width to the images
These optimisations performed are available from Cloudinary out of the box, and we only need to manipulate the image URL. So this is what we had before:

And we merely turned this into:

- f_auto delivers the right image format to the browser (WebP for Chrome, JPEG2000 for Edge etc.)
- q_auto reduced the quality of the image without a visual impact
- w_840 and h_1120 resize the image to be 840 x 1120 pixels
All these options above help us reduce the size of the image.
And the result?
The same number of images that now only contribute to 1MB of the weight of the blog.
Please note that the optimised page was created entirely manually.
Clearly there's a need to handle images online - especially in blogs which could display a lot of visual content. Having a third party solution integrated would help achieve this goal. Cloudinary has a plugin for WordPress to manage image galleries - such a plugin would make a great addition for Ghost as well.
DPR, Responsive Breakpoints
We could go fancier and change the DPR of the image as well as add responsive breakpoints. To do this, we can use the dpr_auto flag, and Cloudinary has a Responsive Breakpoint Generator to further aid us in adding such breakpoints.
To read more about DPR and Responsive Breakpoints, please read Responsive Images with 'srcset' and 'sizes'
Watermarks, because, we can
While creating this article, I knew I wanted to concentrate on performance comparison between the Ghost "native" image solution vs Cloudinary, but it occurred to me that a lot of bloggers like to place a copyright message or a logo as a watermark to images. This couldn't be easier by using Cloudinary:

- After
/upload/we find the previously mentioned options
- After these options we get another set of content between
//- think of this as a layer
- l_logo is a layer referencing an asset called 'logo' (already uploaded in a Cloudinary account
- w_80 is the width of the logo
- g_south_east is the location of the layer
- x_5, y_5 indicates the location of the logo: 5 pixels away from the south east corner of the main image
And the result looks like this:
Here's the image that we have seen previously and notice that now in the bottom right corner the Cloudinary logo appears (any logo can be used as an overlay watermark) - all this achieved again just by manipulating the URL.
Feature request
There's an open feature request for Ghost to have an improved Media Library added to the project - take a look at it, upvote it and add your thoughts.
There are a bunch of plugins that integrate Ghost with Cloudinary already, and you can find them in the official Ghost Documentation.
Ghost, as a blogging engine has been my favourite for the past many years and it's packed with great features however as noted in this article there's a lack for image management and there's a lot more that could be done regarding image delivery and manipulation. Such addition(s) - should those be created by the Core team or as an open-source contribution - would not only be convenient but it could help immensely with site performance and using a tool such as Cloudinary would come with extra benefits on top of image management - such as adding watermarks to images.


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Jannis Geronymakis (b. 1988 in Rotterdam, the Netherlands) lives and works in Rotterdam, the Netherlands and Istanbul, Turkey.
In my artistic practice I use photography as a medium to understand, observe and discover my surroundings, but also to explore the emotions within me and the memories I have from my childhood.
As a child, I had to travel a lot between both families since my father is Greek an my mother Dutch. Many of the scenes that I witnessed there are always with me. After many years when I started to discover photography, I started to use this medium as a way of expression and channelize these emotions within. Traveling started to become an important part of my projects, making a journey is something implemented in my blood since my youth.
Personally, I see my photographs as visual diary notes. My projects can be read, to a certain extend as a journal. They form a poetic embodiment where I translate my visual encounters to a tangible object. I take these pictures with the knowledge that they are always part of bigger whole, but as a photograph they should be able to stand by themselves.
2010 – 2015 Bachelor of Fine Arts, Photography department, AKI Artez Academy for Art & Design, Enschede, NL – graduated 2015
2007 – 2010 Desktoppublishing, Grafisch Lyceum Rotterdam, NL – graduated 2010
Past Exhibitions
2018, Leitmotif - NUN kunstruimte, Arnhem, NL - Group show with Hannelotte van Elst and Aalt van de Glind
2016, This Art Fair, Amsterdam, NL - Fair/Group show
2016, STROOP, Rotterdam, NL - Group show
2016, ARTzaanstad, Zaandam, NL - Fair/Group show
2016 Darmstädter Tage der Fotografie, Darmstadt, DE - Group show
2015 ArtEZ Academy for Art & Design, Enschede, NL - Graduation show
2013 B93, Enschede, NL - Duo show with Aalt van de Glind
2012 Am Hawerkamp, Munster, DE - Group show
Given Workshops - Lectures
2019 Reading Balat through photography - Altinbas University, Istanbul, TR - Workshop
2019 Photography as a tool for observation - Altinbas University, Istanbul, TR - Workshop
2018 Understanding photography by
making a pinhole camera - MEF University, Istanbul, TR - Workshop
2018 On photography, time and urban space - Urban Dreams workshop, Chamber of Architecture Istanbul, TR - Lecture
2018 Photography as an idea, act, and tool - Arel university Istanbul, TR - Lecture
2017 Understanding photography with the pinhole principle - MEF University, Istanbul, TR - Workshop
2016 Crowdfunding through VDK for the publication of Caucasian Encounters
2016 Caucasian Encounters - Self published
Publications & Other
2018 Mister Motley, 'Voorbij het lijfelijke' - online publication
2017 Kiosk of Democracy - Online Publication
2017 Rencontres d'Arles - Book expo
2017 FotoFestival Naarden - Book expo
2016 Darmstädter Tage der Fotografie - Catalog
2015 Synoros - online publication


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Dose Defining Study For MK-2206 Combined With Gefitinib In Non Small Cell Lung Cancer (NSCLC)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01147211
Recruitment Status : Unknown
Verified April 2013 by National Taiwan University Hospital.
Recruitment status was: Active, not recruiting
First Posted : June 22, 2010
Last Update Posted : May 3, 2013
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
This is a phase I study of MK2206 (an AKT inhibitor)and gefitinib in nonsmall cell lung cancer patients who failed prior chemotherapy and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI). The patient population is enriched for EGFR mutations.
The purpose of this study is to determine whether it is safe to administered MK-2206 in combination with gefitinib in adult patients with locally advanced or metastatic non-small cell lung cancer. The second purpose of this study is to define the MTD (Maximum Tolerated Dose) of MK-2206 when combined with gefitinib.
A standard 3-3 dose escalation scheme of MK-2206 with fix dose gefitinib is used in this study.
|Condition or disease
|Non Small Cell Lung Cancer
|Drug: MK2206
|Phase 1
Preclinical data from communication with Merck clinical and pre-clinical group support the application of MK2206 and an EGFR-TKI, and the synergistic effect of this combination. This proposed study is a phase I dose defining study to define the MTD (Maximum Tolerated Dose) of MK-2206 when combined with gefitinib.
MK-2206 is a potent, orally active, allosteric inhibitor of human AKT1, AKT2, and AKT3 with preclinical anti-tumor activity.
This is a Phase I, single-center, open-label, non-randomized, dose-escalation study in patients with locally advanced or metastatic NSCLC. Patients who previously failed and progressed through EGFR inhibitor such as erlotinib or gefitinib and up to one line of chemotherapy will be enrolled into the study. Patients will be administered with oral MK-2206 and a standard dose of EGFR inhibitor gefitinib.
This study will be conducted in three cohorts to identify a recommended Phase II dose (RP2D) of MK-2206 in combination with standard dose of gefitinib (250 mg QD). Cohorts of 3 patients will be enrolled sequentially on escalating doses of MK-2206 administered in combination with a standard dose of gefitinib. Patients will advance doses of MK2206 if 0/3 patients or 0-1/6 develop DLT (Dose-Limiting Toxicity). If 1/3 patient develops DLT, the cohort will be expanded to 6. If 2/6 patients developed DLT, the dose will be de-escalate to 90 mg Qwk. The highest dose cohort with 0-1/6 with DLT will be deemed as MTD and used as cohort expansion for a total of 15 patients.
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|21 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Dose Defining Study For MK-2206 Combined With Gefitinib In NSCLC Population Enriched With EGFR Mutation
|Study Start Date :
|September 2010
|Estimated Primary Completion Date :
|July 2013
|Estimated Study Completion Date :
|December 2013
Experimental: MK2206 in combination with Gefitinib
MK-2206 will be administered orally in a starting dose level of 135 mg on a schedule of Qwk in repeating 3-week treatment cycles in combination with gefitinib in continuous 21-day cycles for the duration of the study
Drug: MK2206
MK-2206 will be administered orally in a starting dose level of 135 mg on a schedule of Qwk in repeating 3-week treatment cycles in combination with gefitinib in continuous 21-day cycles for the duration of the study
- to provide safety assessment and define dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of MK-2206 in combination with gefitinib in NSCLC [ Time Frame: 21 days ]
- To explore the anti-tumor activity and to assess the pharmacokinetic profile of MK-2206 in combination with gefitinib. [ Time Frame: 21 days ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|20 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must have histologically or cytologically-confirmed locally advanced or metastatic NSCLC who have received EGFR inhibitors (such as gefitinib, erlotinib) for at least 3 months and progressed and also received at least one line of platinum-based chemotherapy. In the MTD expansion cohort, patients must have documented progression on gefitinib, erlotinib, afatinib(BIBW2992) or PF299804 within 4 weeks of starting gefitinib and MK2206 treatment. There should be no anticancer treatment between above mentioned treatment and protocol treatment.
- Patient is male or female and ≥ 20 years of age on the day of signing informed consent.
- Patient must have performance status ≤ 2 on the ECOG Performance Scale.
- Patient must have adequate organ function
- Female patient of childbearing potential has a negative serum or urine pregnancy test β-hCG within 72 hours prior to receiving the first dose of study medication.
- Patient have completed any targeted therapy (excluding gefitinib, erlotinib or any small molecule EGFR tyrosine kinase inhibitors ), any chemotherapy regimens and therapeutic radiation for a minimum of 30 days prior to starting of treatment, and palliative radiotherapy covering less than 30% bone marrow for a minimum 14 days prior to starting of treatment.
- Prior usage of BIBW2992 are allowed if patient failed on BIBW2992 over 3-month therapy.
- Patient, or the patient's legal representative, has voluntarily agreed to participate by giving written informed consent.
- Patient is able to swallow capsules and has no surgical or anatomical condition that will preclude the patient from swallowing and absorbing oral medications on an ongoing basis.
Exclusion Criteria:
- Patient who has had chemotherapy, radiotherapy, biological therapy, or BIBW2992 (except gefitinib, erlotinib) within 30 days (6 weeks for nitrosoureas, mitomycin C or bevacizumab), or 5x half-life, whichever is longer, prior to starting of treatment, or who has not recovered from the adverse events due to previous agents administered more than 30 days prior to Study Day 1. If the patient has residual toxicity from prior treatment, toxicity must be ≤ Grade 1.
- Patients who has had major surgery within 4 weeks prior to starting of treatment or expect major surgery in the study duration.
- Patient is currently participating or has participated in a study with an investigational compound or device within 30 days, or 5x half-life from prior agents, whichever is longer, of Day 1 of this study.
- Patient has known active CNS metastases and/or carcinomatous meningitis. However, patients with CNS metastases who have completed a course of therapy would be eligible for the study provided they are clinically stable for 1 month prior to entry as defined as: (1) no evidence of new or enlarging CNS metastasis (2) off steroids or on a stable dose of steroids.
- Patient with a primary central nervous system tumor.
- Patient has known hypersensitivity to the components of study drug or its analogs.
- Patient has a history or current evidence of heart disease.
- Patient with evidence of clinically significant bradycardia (HR < 50), or a history of clinically significant bradyarrhythmias such as sick sinus syndrome, 2nd degree AV block (Mobitz Type 2), or patients taking non-dihydropyridine calcium channel blockers, or digoxin.
- Patient with uncontrolled hypertension (i.e. ≥160/90 mHg). Patients who are controlled on antihypertensive medication will be allowed to enter the study.
- Patient at significant risk for hypokalemia (eg. patients on high dose diuretics, or with recurrent diarrhea)
- Patient is a known diabetic patient
- Patient has a history or current evidence of any condition, therapy, or lab abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the treating investigator.
- Patient has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial.
- Patient is, at the time of signing informed consent, a regular user (including "recreational use") of any illicit drugs or had a recent history (within the last year) of drug or alcohol abuse.
- Patient is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study.
- Patient is known to be Human Immunodeficiency Virus (HIV)-positive
- Patient currently has active Hepatitis.
- Patient has symptomatic ascites or pleural effusion. A patient who is clinically stable following treatment for these conditions is eligible.
- Patient is receiving treatment with oral corticosteroids (note: inhaled corticosteroids or premedication for chemotherapy are permitted).
- Patient is using a potent CYP3A4 inhibitor or inducer (See Appendix 6.2) for a list of potent CYP3A4 inhibitors or inducers). Patients who have discontinued any of these medications must have a wash-out period of at least 5 days or at least 5 half-lives of the drug (whichever is longer) prior to the first dose MK-2206.
- Patient who has received gefitinib and discontinued due to gefitinib-related toxicity.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01147211
|National Taiwan University Hospital
|Taipei, Taiwan, 100
|Principal Investigator:
|Chih-Hsin Yang, MD, Ph.D
|National Taiwan University Hospital
|Responsible Party:
|National Taiwan University Hospital
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|June 22, 2010 Key Record Dates
|Last Update Posted:
|May 3, 2013
|Last Verified:
|April 2013
dose defining
NSCLC With EGFR Mutation
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


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Part found near WTC from type of jet hijacked 9/11
NEW YORK The New York Police Department said Saturday that what appears to be a part of plane's landing gear wedged behind a building in Lower Manhattan belongs to a Boeing 767, the type of plane that crashed into the Twin Tower of the World Trade Center on September 11, 2001.
But Boeing has not determined from which plane the part originated, whether American Flight 11, which struck the North Tower, or United Flight 175, which struck the South Tower, Deputy Commissioner Paul Browne told CBS News.
Responding to a question why, in one NYPD photo, is there a rope around the plane part, if it just blew off the plane or out of the collapsed towers? Browne said, the NYPD has not determined the significance of the rope entwined in the gear or how that happened.
"It raises the possibility that it may have been in the process of being removed from the roof when it ended up in its current location, but that's just speculation at this point," Browne said.
Since 2002, the New York State Museum in Albany has had in its collection a large landing gear piece that went through the roof to the basement at the same location.
Boeing, while assisting the investigation, is directing queries to NYPD or the National Transportation Safety Board, and declined to identify the part based on the serial number stamped on it.
The NYPD plans to have the area taped off at least until mid-week to allow the city medical examiner to check for any human remains.
"Once all health and safety protocols are complete, we will start moving in equipment and setting up for the sifting operation," the ME's office said in a statement Saturday. "The sifting will begin Tuesday morning. On Monday, we will be finishing testing, setting equipment."
The airplane part was found behind 51 Park Place in Lower Manhattan, two blocks north and one block east of the World Trade Center site, 11 years and eight months after Islamic extremists affiliated with al Qaeda crashed two hijacked Boeing 767 passenger jets into the 110-story Twin Towers that stood there, resulting in the deaths of 2,753 people.
The building and one adjoining it became a magnet of public protest in 2010 when its owner, Sharif El-Gamal, announced a plan for an Islamic Cultural Center on the block, but the original plan to raze the two buildings at 45-51 Park Place and erect a 12 to 13 floor center is not going forward right now, according to someone familiar with the evolving plans.
"It's unclear right now what the size and scope of Park 51 might be," the person told CBS NEWS.
The building has included an Islamic prayer space since 2009, and about 600 people attend Friday prayers there.
Gamal's company, Soho Properties, obtained a third adjacent building, 43 Park Place, in December, for $8 million. It was surveyors working for the owner who discovered the plane part wedged between buildings and called 911.
The owner, who recently obtained his federal designation as a nonprofit and retains unlimited air rights over the properties, is also considering commercial development opportunities, such as condominiums.
An attorney for the owner, Adam Leitman Bailey, told CBS News, "No plans have been decided yet. Not condos or anything else."