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anti-Human p300 Anticorps:
anti-Mouse (Murine) p300 Anticorps:
anti-Rat (Rattus) p300 Anticorps:
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Human Monoclonal p300 Primary Antibody pour ChIP, EM - ABIN152047
Eckner, Ludlow, Lill, Oldread, Arany, Modjtahedi, DeCaprio, Livingston, Morgan: Association of p300 and CBP with simian virus 40 large T antigen. dans Molecular and cellular biology 1996
Show all 9 Pubmed References
Human Monoclonal p300 Primary Antibody pour FACS, ICC - ABIN151948
Eckner, Yao, Oldread, Livingston: Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. dans Genes & development 1996
Show all 6 Pubmed References
Human Polyclonal p300 Primary Antibody pour ChIP, ICC - ABIN152981
Julien, Carriere, Moreau, Roux: mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. dans Molecular and cellular biology 2010
Show all 5 Pubmed References
Human Monoclonal p300 Primary Antibody pour ChIP, ICC - ABIN152048
Eckner, Ewen, Newsome, Gerdes, DeCaprio, Lawrence, Livingston: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. dans Genes & development 1994
Show all 4 Pubmed References
Human Polyclonal p300 Primary Antibody pour DB, IHC (p) - ABIN537611
Jin, Jeon, Li, Lee, Choi, Kim, Lee, Bae: Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. dans The Journal of biological chemistry 2004
Show all 3 Pubmed References
Human Monoclonal p300 Primary Antibody pour ChIP-seq, ChIP - ABIN2668569
Dallas, Yaciuk, Moran: Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. dans Journal of virology 1997
Show all 3 Pubmed References
Human Polyclonal p300 Primary Antibody pour IHC - ABIN6712156
Wu, Li, Li, Ti, Zhao, Si, Mei, Zhao, Fu, Han: LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation. dans PLoS ONE 2011
Show all 2 Pubmed References
Human Polyclonal p300 Primary Antibody pour IHC - ABIN6712098
Zhang, Shen, Liu, Wang, Zhao, Zhang: Hypoxia-inducible factor 1-mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions. dans Journal of cellular and molecular medicine 2012
Show all 2 Pubmed References
Human Monoclonal p300 Primary Antibody pour ELISA, WB - ABIN966068
Stauffer, Chang, Huang, Dunn, Thayer: p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. dans The Journal of biological chemistry 2007
Show all 2 Pubmed References
Human Monoclonal p300 Primary Antibody pour ELISA, WB - ABIN969098
Geiger, Sharma, Kim, Nyborg: The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB. dans Molecular and cellular biology 2008
Show all 2 Pubmed References
Augmenting histone acetylation by Brd4-P300 interaction recruits the chromatin remodeler Brg1 altering chromatin structure.
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis
results were related to endogenous p63-p300 complex formation and Wnt/beta-catenin-responsive gene regulation by p63 in squamous cell carcinoma lines
Data highlight an unforeseen link between CBP/P300 activity and the emergence of dystrophic phenotypes. They thereby identify CBP and P300 as mediators of adult muscle integrity and suggest a new lead for intervention in muscular dystrophy.
Data indicate that activation of beta-catenin-dependent signaling in chronic lung disease leads to changes in mucus and ciliated cell frequency and that P300 and CBP tune the beta-catenin signal to favor mucus cell differentiation.
In which higher levels of P300, but not its homolog CBP.
these data imply an important role for p300 in the pathophysiology of diabetes.
An analysis in B cells confirms the strong dependency on NAP1-mediated H1 eviction for induction of the silent CD40 gene and further demonstrates that H1 eviction, seeded by activator-p300-NAP1-H1 interactions, is propagated over a CCCTC-binding factor (CTCF)-demarcated region through a distinct mechanism that also involves NAP1
SP1 and P300 play an important role during decidualization.
The results represent a conserved mechanism, by which CtBP2 serves as a NADH-dependent repressor of the p300-Runx2 transcriptional complex and thus affects bone formation.
The variant of the CREBBP gene is known to be causative of RSTS Type 1. The variant in the EP300 gene is benign since the father carried the same variant and exhibited no abnormalities. However, functional studies are required to investigate if this benign EP300 variant influences the phenotype in the presence of disease-causing CREBBP gene mutations.
P300 may play a key role in ARDS by positively regulating RORgammat transcription.
Data suggest that dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) functions in enhancer regulation by interacting with histone acetyltransferase p300 (p300)/CREB binding protein CREB (CBP) and modulating their activity.
p300 induces a dynamic hyper-acetylated chromatin state and promotes the formation of active enhancer elements in the non-coding genome, leading to a senescence-specific gene expression program.
Study shows that reduced levels of miRNA lethal 7d in idiopathic pulmonary fibrosis (IPF) compromise epigenetic gene silencing mediated by the ribonucleoprotein complex MiCEE. Hyperactive EP300 reduces nuclear HDAC1 and interferes with MiCEE function in IPF.
A better overview of the incidence of EP300-ZNF384 patients that shows that they have a distinct gene signature with concurrent up-regulation of JAK-STAT pathway, reduced expression of B-cell regulators and reduced DNA repair capacity.
he molecular dynamics (MD) simulation also performed, it reveals the conformational stability and the intermolecular interactions of C646 molecule in the active site of p300.
Data show the critical pathways regulating the expression of ADAMDEC1 and the roles of enhancer RNAs and mechanistically links E1A binding protein p300 (p300) and enhancer RNAs, which is dependent on NF-kappa B (NFkappaB).
Studies demonstrate that miR-500a-5p functions as a tumour suppressor in CRC by targeting the p300/YY1/HDAC2 axis, which contributes to the development of and provides new potential candidates for CRC therapy.
data explain how cellular signalling and the activation and dimerization of transcription factors control the activation of p300, and therefore explain why gene transcription is associated with chromatin acetylation
Muscle-specific loss of either p300 or CBP, be it germline or in adulthood, does not impact energy expenditure, glucose tolerance, or skeletal muscle insulin action.
Combined loss of Crebbp and Ep300 completely abrogated GC formation.
our results indicate that high-dose GluOC triggers necroptosis through upregulation of FasL at the plasma membrane in a manner dependent of activation of CREB-p300, followed by the activation of Fas signaling in neighboring adipocytes
Study in a phosphorylation-competent p300 (G442S) knock-in mouse model that ectopically expresses p300 phosphorylation in a homologous site to CREB binding protein Ser436 suggest that a single phosphorylation change in p300 has the capability to modulate hippocampal neurogenesis, Creb binding, and associative fear memory.
The data indicate that brachyury mediates acetylated H3K27 recruitment through a physical interaction with p300 during the mouse mesoderm development.
Data suggest a role for CBP/p300 in testis determination mediated by control of histone acetylation at the Sry locus and reveal a novel element in the epigenetic control of Sry and mammalian sex determination.
Study in mouse model found that liver stiffness activates hepatic stellate cells differentiation into myofibroblasts, which required nuclear accumulation of p300.
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 and Crebbp are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 = E1A binding protein p300; Crebbp = CREB binding protein)
Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP is required for the recruitment of p300. Increased expression of TonEBP enhances the NFkappaB activity and reduced TonEBP expression lowers it.
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 sequentially shape dynamic enhancer landscapes during cell differentiation
Data show that LPS induces endoplasmic reticulum (ER) stress and P300 activity via the XBP1/IRE1 pathway.
Loss of p300 expression is associated with leukemogenesis.
UTX-MLL4-p300 transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 and HDAC1-HDAC2 has been described.
Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc binding to acetyltransferase p300 in myeloid cells; Prmt1 inhibition decreases p300 recruitment to c-Myc target promoters and increased Hdac1 recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc = Proto-Oncogene Proteins c-myc; Hdac1 = histone deacetylase 1]
In line with the acetyltransferase activity of p300, H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC activity maintains PTGES1 expression by recruiting p300 to its gene
ARX positively regulates Wnt/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo repeats in beta-catenin to promote Wnt/beta-catenin signaling. In addition, we found BCL9 and P300 also interact with ARX to modulate Wnt/beta-catenin signaling.
2-O, 3-O desulfated heparin inhibited HMGB1 release, at least in part, by direct molecular inhibition of p300 HAT activity.
work shows that helenalin acetate inhibits C/EBPbeta by binding to the N-terminal part of C/EBPbeta, thereby disrupting the cooperation of C/EBPbeta with the co-activator p300.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
histone acetyltransferase p300
, histone acetyltransferase
, E1A binding protein p300
, histone acetyltransferase p300-like
, E1A-associated protein p300
, E1A-binding protein, 300kD
, p300 HAT


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Airlines That Offer Free Baggage to Military & Dependents
Updated as of 11/5/2018:
With the rising cost of flights it's no secret that military members and their families are looking for ways to minimize the cost of travel. One of the ways to save on the total cost of flight travel is utilizing the free baggage policy for military that many airlines offer. While some of these baggage free baggage deals are only offered to the military member, there are a few open to dependents too.
There always seems to be confusion on which offer airlines offers what so our team did the research for you and compiled it here all in one place. Click on the Airline Titles for the official details from the airline.
Spirit Airlines
"Spirit, we will provide two free checked bags and a free carry-on, in addition to the already free personal item. The U.S. military member should arrive early enough to have their bags checked at the counter, and present their U.S. military ID." This deal only applies to the Active Duty member. Active duty U.S. Military can now save time at the airport by validating their active duty affiliation online during their Spirit.com booking using ID.ME, a third party verification service. Simply click on the "verify" button at checkout via Spirit.com to validate your active duty status and claim your free checked and carry-on bags."
SouthWest Airlines
"Military Passengers traveling on active duty or permanent change of station orders will be exempt from the two-piece Baggage limit and will not be subject to excess, oversize, or overweight Baggage charges, provided that none of the pieces of Baggage exceeds 100 pounds in weight and 80 inches in size (L+W+H)". Also keep in mind that SouthWest does offer military fares.
Not only does Delta have a military and government desk and offer a military baggage policy they even offer special military flight discounts and special military offers through Delta vacations.
Military members on orders are allowed:
(5) free 100 pound bags at 80 inches and if orders ( remember if your traveling with the military members dependents bags can be included in this)
(2) free 50 pounds bags at 62 inches if on personal travel in economy and (3) 70 pounds bags if in first class. (if dependents are traveling with service member then your bags can be included in this).
Bags can be checked for no fee under the following circumstances:
Active duty traveling for duty (and dependents)
5 bags each for you and dependents traveling with you on the same itinerary
You will be required to show travel orders and DOD Common Access Card
Active duty traveling for leisure (and dependents)
2 bags each for you and dependents traveling with you on the same itinerary
You will be required to show DoD Common Access Card
Additionally military personnel and dependents who are members of Veteran's Advantage can get a 5% military discount of their flights. Details here.
American Airlines
- Active U.S. military and/or dependents with ID traveling on orders (1st – 5th bags free of charge)
- Active U.S. military with ID on personal travel
You can call 1-800-433-7300 to see if there is a military or government discount for the city you'll be traveling to.
United Airlines
- Active U.S. military personnel and their accompanying dependents, not traveling on official business, receive waived service charges for up to three checked bags at 70 pounds (32 kg) each.
- Active U.S. military personnel and their dependents traveling on official business receive waived service charges for up to five checked bags at 100 pounds (45 kg) each.
- Dependents traveling with active U.S. military personnel are also exempt as long as they are traveling in the same reservation.
Alaska Airlines
Military personnel and dependents traveling on orders get up to 5 bags each free up to 75 pounds and 115 inches or less.
Allegiant Airlines
Under the Allegiant Honors program U.S. active duty military, retired military veterans, members of the National Guard, military reserve and their dependents are eligible for free services when they fly Allegiant. These include up to three pieces of checked baggage, one carry-on bag, one pet in cabin, courtesy boarding pass printing at the airport and free seat assignments, pending availability. In addition, active duty military may board flights with priority boarding at no charge, and will not be charged a change or cancellation fee due to a change in orders.
Frontier Airlines
Via ThePointsGuy.com "Frontier Airlines offers free checked baggage to Active Duty Military.*** They require an active duty ID and/or that you are in uniform at the airport. You can not add your baggage online. You must check your baggage at the airport in order for the fees to be waived."
Bonus Military Offer from Expedia
Don't forget that Expedia offers a military promotion where you can earn free points, receive upgrades and so much more. I've personally received some of the best rates from them. Click here to sign up (it's free) for this offer.
Up to $40 off Military Travel At CheapOAir + CashBack From Ebates

subset: commoncrawl


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Did you know there is a summer day camp for 7-12 year olds and a teen camp for 13-15 year olds at Cave of the Mounds?!
Here are some fun activities to do before or after your visit!
- PreK-Grade 2 Activity Sheets:
Polly the Parrot Maze (79KB)
- Elementary Activity Sheets:
Introductory Cave Word Search (77KB) – Intermediate Cave Word Search (98KB)
- Advanced Activity Sheets:
Advanced Cave Word Search (98KB) – Cave Word Scramble (78KB) – Cave Crossword Puzzle (79KB)


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I was perusing Instagram one day, and noticed a comment on one of my cigar pictures mentioning Hendrik Kelner Jr. The comment was from El Cedro cigars, so I did a little digging and found out this was another brand produced from Kelner Boutique Factory (KBF). ARZ are Phoenecian letters that stand for Cedar and bear the name of El Cedro's initial release. At the time, the owner contacted me for review after IPCPR, as his line had not yet been released. Fast forward a couple months, and a package arrived at my door with two robusto's for review. Given my previous experiences with KBF cigars, I was excited to review the El Cedro to say the least. Anwar Elboustani is the owner of El Cedro, and the blend specifics are not transparent, but we are working on getting him on Cigar Chat to discuss the future of El Cedro.
Wrapper: Dominican Republic
Binder: Dominican Republic
Filler: Dominican Republic, Nicaragua
Dry Draw: honey, cinnamon, hint of pepper
First Third: Honey immediately hit my palate, complimented by a mild cinnamon draw, and light finish mid-tongue. The retrohale was all cedar, and much stronger then the draw, providing a nice balance of mild-medium flavor interaction on my palate. The front of my mouth and lips had a rich long finish from a creamy draw; wonderful complexity that I related to custard. A note like that is really a conglomeration of notes, suggesting balance and depth between the flavor profile and texture of the draw. Just like the other KBF offerings, the ARZ had a noticeably long finish. As I neared the second third, the finish overwhelmed me as I sipped on my ice water, compelling me to continually note how long it was.
Second Third: I wish the El Cedro was a cream soda really. If someone packaged this finish in a carbonated beverage, I would buy it. That is the best way to describe the flavor profile at the beginning of this third, and I am a huge fan of small batch cane sugar sodas and root beers. Approaching the mid-point, the honey subsided a bit, and some of the creaminess went away. A green vegetal note entered, with no pepper really, almost like fresh pablano or grassy notes found in some Habanos. The grassy nots came from the retrohale, and combined with the cedar to add depth as the creamy custard profile was still there. Towards the end, medium coffee bean notes began to arrive, as the body and finish of the El Cedro moved toward a medium body, full flavor cigar.
Final Third: Bitter nuts entered the profile at this point, similar to a cashew at first, with the cedar, grass, and coffee bean notes. Another wonderful transition took place at this time. I remembered Rob speaking of almond liqueur in a cigar, and this really reminded me of that. The strength of the retrohale burn combined with the nut notes to remind me of a liqueur burn. I cannot wait to see if Rob detects this note as well in the El Cedro. The almond note became the most dominant of the final third, and the previous notes all lingered in the background, as the ARZ picked up steam nearing the nub.
Construction: Prefect
Final Thoughts: This is an immediate box buy for me. I could smoke this every day, and I think the old school Habanos fan will love the El Cedro. To me, this cigar was blended for that palate, and it speaks volumes to Kelner's ability, as each KBF cigar I have reviewed catered to different palates. I do not think the ARZ is so much about depth and complexity, as it is sharing a rich experience and a classic profile. I wanted to drink this cigar the finish was so damn good. Like a classic Habanos, it starts with an excellent mild-medium flavor profile, and consistently builds in body and flavor until the end. Of all the KBF cigars, this was my favorite, and I could smoke this every day. I have a feeling Anwar and I like the same stuff, and I am very glad he produced this. I recommend it to everyone really, although I would suggest it as a morning or first cigar of the day to the modern full body smoker. I would have no problem handing an El Cedro to anyone to share a special occasion, and I think Habanos fans will really enjoy El Cedro's offerings. As I have stated before, if you see the Havana Saver in my review, it is because I loved the cigar.
Final Final thoughts: Kelner Jr has hit three homeruns to me, regardless of what subjective opinion one might have about any of the blends. Cigars are about different tastes, different palates, and creating experiences for people to share. I see no reason why anyone could not find a cigar in the KBF catalog that would fit their palate. Furthermore, the distinction between the blends, tells me he is not blending for his tastes; rather, identifying what his customer wants, and delivering it. All too often, it is easy to tell which blender blended a boutique cigar, but that is not the case with KBF. I cannot say at this point that there is a common denominator between the three companies, other than fantastic finishes that seem to last forever.
*You can buy El Cedro 14k HERE!
**You can follow El Cedro @El_Cedro_Cigars
***You can follow me @CatfishBluezz
Views: 437
Excellent review, brotha! Sounds like a good palate tester for me. Glad to hear you enjoyed it so much!
This is definitely on my must try list. Going to have to get an order in as soon as i knock out a few remaining habanos boxes. Excellent review as always.
Nice review. I have one headed my way in the RobbyRas sampler. Can't wait to try it!


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But it also takes a lot of work like any other business.
You will be starting out from scratch.
Starting a business online does not cost as much to start up as a physical business would.
You do not have to buy or rent a building for starters.
You can work from the comfort of your home.
Now I am not saying it won't cost you anything.
You will certainly have some costs.
Web site hosting, software tools, it depends on what you will be doing.
The costs are minimal though.
First of all do not fall into the trap of thinking you are going to get rich over night.
That will not happen.
Like any other business, you have to grow.
It takes time,and patience.
You will want to research the area you want to get in to make sure it will be profitable.
When you find that niche you want, then do all the research on it that you can.
Make yourself an authority on that niche.
Work it.
Own it.
Make it yours.
If you are not sure what you want to do yet, look inside yourself.
What do you like to do? What are you good at? What jobs or training have you had? Maybe you have a hobby that could lead to a business idea.
The possibilities are endless.
Give it some thought and do your research.
There are software tools for that too.
When you find that something, then set yourself up a plan.
Something that will help you focus on one thing at a time.
Do it step by step.
Start a task, finish it completely and move on to the next one.
There is a vast amount of information available on the Internet to help you.
Do a Google search.
Go to the different forums.
The Warrior Forum is a good one to start with.
If you want to get into Internet Marketing, then you can learn a lot from this Forum.
There are many membership sites that are free to join or have a small fee to join.
Look around at the different options you have.
You could build your own website, or if you are not experienced enough for that then try setting up a blog.
A blog is pretty easy to set up and you can find one for free.
Again, just do a Google search.
Pretty much all of them have tutorials to help guide you along the way.
You can also earn money from your blog by selling affiliate products.
If you want to do this, make sure you find a blog that will allow this as some will not.
If you find yourself getting frustrated about something, and you probably will from time to time, then just step away from it and clear your head.
When you come back to it you will be ready to dive right in again.
If you find yourself surrounded by too much information, remember to Focus on one thing at a time.
Read it.
Learn it.
Use it.
And do not be afraid to purchase a software program or two to help you.
There are a lot of programs made to help you in just about anything you want to do.
A good software program can save you valuable time and energy.
Consider these as tools of the trade.
Don't be afraid to ask for help.
There are a lot of people out there who will be glad to help.
Sign up for some free memberships.
Sign up for some newsletters, they often have mini courses that they send out.
Sign up for some giveaways.
This can all be quite valuable to your success.
The more you learn the farther you will go.
The information is out there waiting.
Go get it! Remember:
- Do your research.
- Make a Plan
- Focus on one task at a time
- Take a break and clear your head.
Once you start learning you will find it becoming easier to do.
Before long you will become the next Internet Guru.
At the very least you will feel like a Guru! Good Luck in whatever you choose to do!


text: 4 out of 5 star Rating Great product for the price By NSWW on February 23, 2014 This chain works great for me with delicate gold filled charms. I always wish items have the lobster clasp instead of the spring ring, but I do like the little link they put on the opposite side of the clasp to make it easier to close. As for the previous reviewer- gold filled can react different on various people and I have used thousands of these and other similar art beads chains along with charms I sell to customers, and in my experience, I have only had 2 customers ever report reactions- which can be caused by so many other factors- not just the chain itself: someones body chemistry, lotions, perfumes�. I will continue to buy:) Was this review helpful to you? Yes or No Flag as inappropriate 1 person found this review helpful


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From Motorboards
A community wiki dedicated to the Go Motorboard's 1500X, 2000X and 2000XR motorboards. This wiki is supported by a volunteer community and is not in any way affiliated with Roth Motors or Go Sporting Goods, etc. It is a non-commercial site, and everything here is available under the terms of the GNU Free Documentation License. Why in the world would anyone want to support a product from a company that went bankrupt? Click here.


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By MIRANDA G. BAILEY
Staff Writer
Retired PHS Chemistry teacher Elaine Ledbetter is a hidden jewel no more.
Thanks to the hard work and gracious
appreciation of one of her former students, Mrs.
Ledbetter's life is now chronicled on the information superhighway.
Elaine, 81, has her own web page.
PHS graduate R. Malcolm Brown Jr.,
a prominent University of Texas botany professor, set
up the web page in his favorite teacher's honor this year because he said he feels the rest of
the world deserves the opportunity to get to know Elaine Ledbetter.
"Elaine is a hidden jewel. I had
her poetry journals for years," Brown explained. "I thought
what a resource she would be if the world could see her work."
He continued, "I decided to make
a web page because I wanted people to appreciate Elaine.
She's kind of like Shakespeare up here in the middle of nowhere."
Months in the making, Brown complied
her poetry volumes, a book about her life, and
artistic photographs the teacher has taken. He designed the web page himself and has placed
it on a computer server from his University of Texas office. He said this server gets at least
50,000 "hits" or inquiries a month.
As an added bonus, readers will
get the chance to enter the world of Elaine Ledbetter with
the sweet sounds of background piano music played by Brown. With only the click of a
button, many of her poem's can be read with accompaniment pieces composed by Brown. He
wrote the songs specifically, he said, with Elaine's words in mind.
"Of all the honors I've received, this tops them all," Elaine said.
Brown looked a little taken aback by her comment.
"Do you know how many honors she has received?"
Ledbetter's work on teaching chemistry
in Pampa and her involvement as president of a
national science teacher's organization has brought her many honors in her lifetime.
At one point, she received a year-long
scholarship that allowed her to observe 2000 science
classrooms all over the country. She wrote a book, "Keys to Chemistry," that sold 100,000
Mrs. Ledbetter was responsible for
promoting some of the first student science fairs in
Pampa more than 40 years ago, when science fairs were first becoming a trend. She went on
to accompany many of her students to regional fairs, and some of them to national level
R. Malcolm Brown Jr. was the first student she went with to a national fair in California.
It was this event that changed the course of her life, she says in her book, "Called to Teach."
Malcolm won the regional competition
and qualified for the national science fair at a time
when her teaching had become what she described as "stale."
I was seriously thinking about giving up on teaching, said Ledbetter in her book.
When Malcolm qualified for the competition,
they were both flown to L.A., and it was during
her time in California that her eyes were opened to the new ways science could be taught
through science fairs, and more hands-on experiments. She said the fair inspired her, and
gave her a new perspective on both science, and teaching.
"Now you're going to inspire more people," Brown said.
He and his wife Ann drove to Pampa
over the weekend to show Elaine the web site in
"I predict you'll get 1,000 responses a month," he said.
Brown presented Elaine with a copy
of a letter he's already received from a reader in
Pennsylvania who happened upon the web site.
"Thank you for allowing me to enter a site of sheer enjoyment," the letter read.
Brown has sent a link to Elaine's web site to Pampa ISD Superintendent Dawson Orr.
"I hope school kids can identify
that teachers can be so important. And Elaine has had such a
tremendous impact on so many people," said Brown.
Brown said he has been talking with
Doug Locke of Pampa Cybernet, also a former student
of Mrs. Ledbetter, and he hopes to get her computer set up with Internet access shortly.
The web page can be accessed by going to www.botany.utexas.edu.
Computer surfers will find Malcolm
Brown's name with a box beside it. Click there, he said,
it will take you to his personal web page, and it is there you will find the world of Pampa's
Elaine Ledbetter.
Back to Elaine Ledbetter Main Page- Click HERE
Go Directly to the Pampa News Online- Click HERE


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Integrazione Strutturale è una forma di terapia fisica dei tessuti molli e rieducazione del corpo attraverso il movimento e il tatto. Sistematicamente dissolve i tracciati di stress e tensione che inibiscono il corpo dal muoversi liberamente
Le persone cercano Structural Integration come un modo di ridurre il dolore e lo stress cronico e aumentare le prestazioni nelle loro attività professionali e quotidiane.
La Fascia è il Tessuto Connettivo che ricopre ogni muscolo, organo, tendine e legamento.
(English) The Positive Impacts of Structural Integration On Children's Health at an early age gives them ease with their own bodies and develops confidence in their self image.
(English) Many scientific studies have been performed to confirm the effectiveness of the Structural Integration.
(English) Here are some videos of Dr Rolf and working with clients and talking about Structural Integration.
(English) Here you will find before and after pictures of people who have gone through the 10 sessions of Dr Rolf's Structural Integration. Among the benefits, people report feeling taller, moving easier, having more energy and at ease with their bodies.
Costo ?
In che modo Osteopatia, Chiropratica e massaggi sono differenti da S.I.?
Dr. Ida P Rolf la fondatrice di Structural Integration ha conseguito il suo PHD in Biochimica presso l'Università della Columbia negli anni '20.
(English) Larry Dossey, MD, best-selling author
"There is one major reason to take Rolfing seriously: it works. Not only can it dramatically change people's bodies, it can transform their lives as well. Rolfing is powerful stuff."
Dr. Jacob Teitelbaum, a board-certified Internist and head of a fibromyalgia research clinic in Annapolis, MD, says "rolfing is a very powerful tool, and a very important tool for me to have for my patients. People who have suffered from chronic pain for 20 years will be amazed at how their pain goes away."
"I send my patients to Chris to receive Structural Integration sessions as it is a whole body approach rather than treating symptoms".
Dr. Blumberg GP, Auckland N.Z
"Having lived with back chronic pain for a long time I had tried lots of therapies. Then I found Chris. Only after a few sessions of Structural Integration, I had more flexibility and range of motion and I could move easier. I now live without chronic back pain after completing the 10 series. I feel like I have been given a new lease on life !"
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"He is a great therapist in the method he works on Rolfing – Structural Integration. He worked on me and helped me so much to deal with the pains in my body. A big Thank you!"
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Star Wars : Kylo Ren - S.H.Figuarts
Prices are automatically linked to market prices in Japan, some rare items are more expensive than regular price.
In Stock
Inventory information is updated once each day. All products are new, however, the condition of the box is not guaranteed.
Product Shipping Estimate: [How to Calculate Shipping Cost (?)]
- Asia (Registered Air): US$8.76
- Oceania,North America,Central America,Middle East (Registered SAL): US$10.86
- Europe (Registered SAL): US$10.86
- South America,Africa (Registered SAL): US$12.13
You may be subject to import duties and taxes. [... more info (?)]
- Code: 117031
- Japanese: S.H.フィギュアーツ スター・ウォーズ カイロ・レン 約160mm ABS&PVC製 塗装済み可動フィギュア
- Weight: 0.178kgs
- Package Size: 4cm x 18cm x 14cm
- Manufactured by: Bandai
- Release Date: Friday 18 December, 2015
by Salvador
SH Figuarts kyloren is an amazing figures. Really nicely detailed with great articulation. Highly recommend this figure which is so much fun to pose. A great addition to the SH Figuarts Star Wars line


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SVGAMP GEF Progamme Launch Today
The St. Vincent and the Grenadines Association of Music Professionals will launch its Global Environmental Facility Small Grants Program project today. The project is entitled "Education Entertainment to influence behavior towards climate change adaptation in vulnerable communities in St. Vincent". The launch takes place at the NEMO Conference Room at ten this morning. There will… Continue Reading →


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Oil jumped this morning, with Brent rising 1%, trading above $56 after the International Energy Agency said OPEC had achieved record initial compliance of 90% with planned production cuts - it is unclear how much of this was self-reported and questionable - while demand grew faster than expected.
In the first month of OPEC's supply cut agreement, key member Saudi Arabia reduced production by 116%, or even more than it had committed, despite Venezuela's struggles to reduce output (it had achieved only 18% of planned cuts) while higher demand is aiding the group's bid to re-balance world markets, the IEA said.
The following Bloomberg chart shows alleged deal compliance by nation...
... and the detailed breakdown is shown below:
The IEA, which advises industrial nations on energy policy, said that if current compliance levels are maintained, the global oil stocks overhang that has weighed on prices should fall by about 600,000 barrels per day (bpd) in the next six months. The IEA also estimated that 11 producers including Russia, Kazakhstan pumped 269k b/d less crude in January versus October-November levels, citing preliminary data.
The IEA also increased its 2016 estimates for world oil demand growth for a third month, and boosted its outlook for 2017, anticipating an increase of 1.4 million barrels a day this year. World oil inventories will fall by 600,000 barrels a day during the first half of the year if OPEC sticks to its agreement, the IEA said.
Oil has fluctuated above $50 a barrel since a deal to trim output between OPEC and 11 other nations took effect on Jan. 1. U.S. producers are taking advantage of higher prices by increasing drilling activity and boosting daily output to the highest level since April, a dynamic the IEA said is capping prices in the mid-$50s.
"There is a demand element to this price rise as well as OPEC compliance," says Michael Hewson, market analyst at CMC Markets. "We're still short of the highs of the month"
"The key question for the oil market is how long OPEC can sustain this deal," Spencer Welch, a director at IHS Energy, said by e-mail. "Historic analysis of similar production limits suggests that 100 percent compliance is unlikely."
While the oil market welcomed the data, which may or may not be accurate as verification remains problematic and recent surges in inventory suggest quite the opposite of what the IEA reports, increasingly more attention has recently fallen on US crude production, especially in light of a recent surge in Permian drilling rigs...
... which threatens to disrupt the much desired supply/demand equilibrium.


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Ashley & Tyler | VA Wedding Photographer
When I first met Ashley and Tyler, we really hit it off and had so much fun together! They are super sweet and I loved spending time with them during their engagement session and wedding. You can see the love between them and they are so adorable together. Their VA wedding took place at a new beautiful venue called Kalero Vineyard in Purcellville. The owners are so nice and have put some much into creating this venue and are still adding things which is exciting!
Ashley and Tyler's wedding day was beautiful with amazing mountain views and perfect weather. Because they live in Loudoun County, they made their wedding have a "home" feeling using local vendors and a map for their guests to sign. My favorite part was watching them read the letters they wrote to each other and seeing them tear up which was so sweet. Ashley was stunning in her Maggie Sottero dress and I loved the colors she picked for her wedding with pink, white and gold which came together so nicely.
Ashley and Tyler went to the same highschool in Loudoun County but never met there! They ended up going to the same university, George Mason and meeting because her sorority sister (a bridesmaid) introduced them. Talk about fate!! He proposed to her in the OBX, (my favorite beach!) in 2017 and here they are married! They couldn't have asked for a better day and I I'm so happy I was a part of it! Congratulations to Ashley and Tyler!
This backdrop! These views!! Perfect spot for a VA Wedding!I love these bridesmaid dresses!!
These girls are stunning together!!
My favorite photo is with the veil creating a soft and dreamy look!
I still can't believe Wegman's made this bouquet. Such a beautiful combination of whites with some flowing greens hanging out.During the reception, we went outside to capture these gorgeous sunset photos. It's my favorite time to photograph!
Florist: Wegmans
Cake: Wegmans
Hair: Stefani Cerula (Styles by Stefani)
Makeup: Priscilla Molina (PriscillaM Beauty)
Caterer: Monk's BBQ
Wedding Gown: Maggie Sottero
Suits: Men's Wearhouse
Coordinator: Leanna Vespar
Invitation Designer: Jennifer Postorino
Wedding Signs: Ashleigh Bramhall, AshleighSignature


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Last night was a perfect reminder as to why I decided to cut back on shows this year. There I was at the Marquis Theater, spitting distance from Norwegian metal-gods Enslaved, before the clock struck midnight, and I was yawning. "As Fire (and a sparse, violent circle pit) Swept Clean the Earth", my mind was losing a battle with my body. As much as Grutle Kjellson and crew were singeing the short hairs off my face with their arena ready black metal sounds, I just found myself at odds with the patched denim posse surrounding me. Having a job where I actually have to get up every morning is killing my ability to partake in these weeknight showcases, no matter how stacked with talent they may be — as last night's Winter Rite Tour surely was.
Occultist rock from the Lone Star State in the form of Ancient VVisdom, bluesy slabs of stoner doom by the female-fronted Royal Thunder, Profound Lore's latest gift to the world, Pallbearer, and of course the progressive-black-metal-done-right masters, Enslaved. The lineup was just too good to miss anything. So it was that by the time we were witnessing the destruction of Led Zeppelin's "Immigrant Song", we were over four hours in, and about an hour past my beer buzz.
New job, having to drive home, getting older…these all played a part in my eventual exhaustion, but that does not mean that my first metal show of 2013 wasn't a great fuckin' time. Coming in hot from Star Bar, where we enjoyed a hefty sampling of some great local brews (I think my tab read something like Deviant Dale's, Double Dry Hopped New World Porter, Lugene, La Folie…), we were able to catch the last few songs from Ancient VVisdom, including the excellent ode to Lucifer, "The Opposition". They reminded my buddy of a (left-hand) Alice in Chains. I really enjoyed their set.
After another Dale's (my last drink of the night), Royal Thunder provided the perfect soundtrack to our Amendment 64. This band reminded me of Witch Mountain quite a bit, but they lacked the charisma found in Uta Plotkin's stage presence. I was definitely feeling the more blues oriented stuff from last year's CVI, but the slower stuff was a bit of a downer.
Pallbearer are a doom metal band from Little Rock, Arkansas and I have been witness to their soul crushing live performance no less than five times in the twelve months since their debut album kick started another banner year for Profound Lore. These guys managed to literally move the audience before the set even started. The bass during a quick soundcheck could have measured on the Richter scale. These guys don't fuck around. Turn it up to 11, rip off the knob, and pour sadness and sorrow over the crowd like molten lava. Pallbearer's songs move at a snail's pace, but Brett Campbell's clean vocals invite you in with the promise of redemption. Expecting something beautiful behind the curtain, somehow you arn't disappointed when you find out there was nothing but a cliff — falling into the abyss has never been so liberating.
Even though I was losing my buzz by the time "The Sleeping Gods" intro came over the PA, Enslaved took no time at all proving why they are one of the best bands making metal today. They manage to combine that early Norwegian black metal sound with something so modern, so progressive and HUGE in sound, that sometimes it blows me away that they are still playing venues like Marquis Theater. I am glad they are, but one listen through RIITTIIR and you know these guys could play the Pepsi Center and make it sound good.
When it comes to Enslaved (unlike many black metal bands), I do prefer the new material. I feel like they've found their sound and really differentiated themselves over the past few years, so some highlights for me were "Thoughts Like Hammers", "Roots of the Mountain", "Ethica Odini" and "The Watcher". But those who were in it for the old school were not to be disappointed — I believe I counted 5 pre-Isa tracks. They even pulled out the 21-year-old "Allfaðr Oðinn".
Besides a few assholes in the pit who were swinging and throwing smaller dudes to the ground, the crowd was great last night and the band seemed to appreciate the energy coming back at them. They gave it their all for over an hour and a half, and although I assume they came back for more after "Immigrant Song", I left the night to those who could handle it better than I.
The Watcher
Thoughts Like Hammers
Ethica Odini
Roots of the Mountain
Convoys to Nothingness
As Fire Swept Clean the Earth
Allfaðr Oðinn
Immigrant Song
Devoid of Redemption
An Offering of Grief
New Song
Given to the Grave


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We're constantly being told about extra steps and products to add to our beauty regimes. Some turn out to be important, and find themselves firmly planted in our daily routines, while others we dabble in, maybe even incorporate and run with. But are all these steps actually necessary?
Primer is one of these products. Hailed as a vital step in your make-up prep, Benefit Make-up Artist Lisa Potter-Dixon strongly believes a primer can transform your make-up. "It's one of those products that, once you start using it, you'll wonder how you lived without it" she says. But what does a primer actually do? Lisa tell us, "primers are great for many things, including giving you an even base ready for foundation, minimising pores and fine lines, taking away excess oil, and brightening." If you have visible pores or fine lines, primer can be a perfect way to smooth them over, meaning your make-up is less likely to settle into them. Lisa adds that "one of the biggest dilemmas out there is open pores", and recommends a silicone-based primer such as Benefit's The Porefessional, which is specifically created to stop your make-up showing or settling into your pores.
It's one of those products that, once you start using it, you'll wonder how you lived without it.
Primer also helps your make-up stay put for longer. Amy Conway, Bobbi Brown Make-up Artist, says it "ensures you are creating that perfect barrier between skin and make-up". After all, if you apply make-up directly on top of moisturiser, it's more likely to slide off your face and not go on evenly. And, primer helps it stay on evenly, no matter what your skin type.
Those with oily and dry complexions will know, your skin can really impact on your make-up throughout the day. Amy agrees that primers can problem solve for all skin types: "for oily skins it stops the oil seeping through your make-up, and making the make-up slide. And for dry complexions, it stops your skin from almost acting like a sponge and soaking up the make-up, causing it to look patchy."
Oily skin types find that excess sebum means their make-up doesn't sit well on their skin, or stay put for long and needs constant re-application. Amy recommends silicon-based formulas: "it absorbs oil and reduces the appearance of pores and refreshes and smooths skin." Tarte's Timeless Smoothing Primer also has a mattifying finish – perfect for oilier complexions. Or if you have oily skin but still want that hydrated feeling, Laura Geller Original Spackle Make-up Primer gives the best of both worlds, keeping oil at bay while feeling light and refreshing on your skin.
If dry skin is your issue, primer can be your best friend. Amy says "dry skins should opt for a hydrating primer, these ensure you are locking the water into the skin". These offer relief to parched complexions and help to even out any super-dry, flaky patches. Look for lightweight, moisturising formulas with skincare-specific ingredients like vitamins A, C and E, and hyaluronic acid – we love Nude by Nature Perfecting Primer (it has all those hydrating vitamins), while the Bareminerals Good Hydrations Primer has both coconut extract and hyaluronic acid, perfect for locking in moisture.
A primer can also correct unwanted tones in the skin, such as dullness, sallowness and redness. Bareminerals Vio-Lit Glow Primer is a universally lifting violet hue, illuminating any skin tone, while Laura Geller Soothing Spackle Make-up Primer features green pigments to help disguise redness. Amy adds that any complexion can benefit from a colour-correcting primer: "colour-correcting primers are not only great to even out skin tone, but a perfect way to give the skin a 'pick me up' in the winter months." So if you're missing your sun-kissed summer complexion, Amy advises: "opt for a pink tone to brighten and lift the skin" (try Pixi Glowtion Day Dew with its illuminating pink pearl pigments, or oily skin types should go for Benefit Porefessional Pearl Primer), or for red or uneven skin tones "a warm yellow undertone will cut out any redness and give a gorgeous winter glow with it." We love Illamasqua Beyond Veil Primer, which adds a subtle radiance to skin.
So, the answer to our question is – a big, resounding yes. If you want your make-up to apply smoothly and evenly, not settle into pores or lines, and stay put evenly for longer – and let's face it, we all want that – then a primer is a core prep step. Plus with additional benefits of colour-correcting, illuminating and troubleshooting oily or dry skin issues, they do so much more. It's official, primers are an absolute make-up bag must-have.


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Many people find themselves in situations where they can't afford their bills. Whether it's a result of a medical condition or your school loans, you have every right to get out of debt and to balance your financial future. As a young adult, you've just finished college and are starting a good job. Now focus on paying down your debt with these tips.
Don't let the shame of debt keep you from making a fresh start
For far too many middle-class Americans, personal debt is a shameful secret that they carry with them every day. Their indebtedness covertly impacts many of their decisions, their interactions with others and even their concepts of self-worth.
Monitoring credit reports for inaccuracies
As many Pennsylvania residents may know, making payments on time and using credit judiciously influences its availability in the future. It may determine whether purchasing a motor vehicle or a new home with credit is possible. Before extending credit, lenders examine credit reports, and an uncomplimentary entry may make the difference between receiving a loan or not.
Understanding the consequences of a spouse's bankruptcy
Pennsylvania residents who are worried about interest rates and applying for a loan debt management may be interested in some information on how bankruptcy can affect a couple. Marrying someone with debt issues can present some unforeseen problems that may need to be discussed prior to marriage.
Rebuilding credit after being denied a secured credit card
Pennsylvania readers who have been turned down for a secured credit card may be wondering what they can do to rebuild their credit. A secured credit card is a great way to re-establish a person's credit rating following a bankruptcy or other financial setback. However, it is possible for someone to be turned down for a secured credit card, according to some credit management writers.
Ramifications of medical and credit card debt in Pennsylvania
The subject of whether credit card debt or medical debt is worse can come up often among consumers. Approximately 43 million consumers in the U.S. are dealing with some medical debt on their credit reports. Both types of debt have their own particular implications. Credit card debt, however, has more of an impact on a consumer's overall credit score than medical debt.
Identifying the best ways to settle debt
Pennsylvania residents may not be aware about the difference between credit counselors and debt settlement companies. While there are some similarities between the two, there are many differences as well. Understanding which option is the best to utilize when settling debt can be extremely important.
Ways to rebuild credit
Pennsylvania residents who have filed for bankruptcy in the past may know that it is important to begin rebuilding credit. Obtaining credit may be the first step in proving that handling debt is once again possible. While bankruptcy remains on one's credit report for up to 10 years after it was filed, creditors often look at how both current and prior debts are being handled. If current bills are paid on time, past delinquencies may be overshadowed. Being proactive and applying for a credit card may be another way of showing creditworthiness.
Debt management strategy involves prioritizing
Pennsylvania residents might be interested to learn about some debt management strategies that can be used for long-term financial health. After gaining extra funds that could be used to pay off debts, many households would be eager to pay down their mortgage. According to some financial experts, however, a mortgage normally falls into the category of 'good debts" and should be paid off last.
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Accumulating a large amount in debt can make it challenging to pay it all off. Losing a job or other unforeseen circumstances can cause people to be overwhelmed with debt. Pennsylvania consumers may wish to better manage their debt by hiring a debt management company. The promises some of these companies make can seem too good to pass up, but those promises may be over-inflated or dishonest.


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Preparing Kingdom people,
for Kingdom Purpose,
Possessing the Kingdom.
Exodus 19:6
And you shall be to me a kingdom of priest, and a holy nation:
These are the words that you shall speak to the sons of Israel.
Experiencing DELIVERANCE in teaching, DEVELOPMENT through preaching,
and DISCIPLING destiny through fellowship.
Daniel 7:18
But the saints of the Highest One will receive the kingdom
and possess the kingdom forever, for all ages to come.
Service Times: Sunday* 9:45 AM - 10:45 AM - 6:00 PM


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Intriguing top 5 QB recruit Dorian Thompson-Robinson commits to UCLA
Dorian Thompson-Robinson, the No. 3 dual-threat quarterback of the Class of 2018, committed to UCLA on Sunday via a Twitter post that included pictures of past Bruins greats at the position.
Now it gets interesting.
University of California, Los Angeles.— DTR (@DoriansTweets) April 24, 2017
I'm your Quarterback.
S 1 R O M 8 R I U N. 110% 🐻🏴 pic.twitter.com/8ryfX7oesz
Thompson-Robinson's commitment is interesting from a couple of viewpoints: First, UCLA could be looking for a starting quarterback in 2018 if incumbent Josh Rosen, a rising junior, has a big year in 2017 and opts to leave for the NFL. Second, and even more intriguing, as ESPN noted, "it's slightly premature to discuss Thompson-Robinson as a starting quarterback at UCLA, considering he hasn't yet started a game at Las Vegas Bishop Gorman," his high school.
In fact, Thompson-Robinson — who caught more passes (22) than he completed (21) in his junior season — has attempted only 48 passes while stuck the past couple of seasons behind Ohio State early enrollee Tate Martell and will become the starter only this fall as a senior.
Still, Thompson-Robinson has shown enough to impress the top Power 5 programs and earn a composite four-star rating by 247Sports. He reportedly chose UCLA over Michigan but holds offers from, among others, Alabama, Florida State, Georgia, LSU, Miami, Oregon, Tennessee and Texas.


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Our School Aims are:
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2.To prepare all pupils to embark on a happy and successful life.
To achieve this we believe they need:
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♦ To develop a moral understanding of their actions and choices.
♦ To have a good standard of manners, presentation and personal hygiene.