text:
Nate Lawson has an excellent post on his blog rightly identifying SRP as a superior solution to the Clench implementation. However, upon examination it appears that SRP is encumbered by a questionable patent situation. I would hope that Stanford would be able to release a BSD-licensed version of their SRP distribution sometime soon to enable its adoption everywhere.
Application layer authentication-inherent validation of public key integrity without the use of a trusted third party
Andrew Auernhemer and Jordan Borges.
This is the initial unveiling of the pre-alpha version of Clench, Goatse Security's new simple password-based authentication mechanism that rids most organizations of a need to rely upon an untrustable third party to ensure against man-in-the-middle attacks.
un-tl;dr abstract: SSL is broken. Certificate authorities only exist to let the US, Chinese, Turkish, Brazilian etc etc government or Russian mob spy on you (whichever is interested first). Well, I guess they also exist to line the pockets of assholes who want $10-50 for pushing a button. Luckily, we've remedied this! We've established a way that a client, using only standard password authentication, can validate a server's public key and ensure that no third party is listening (without the use of a trusted third party such as a certificate authority or manual fingerprint verification). Read on for a wonderfully simple hack and proof of concept code!
Biggest problem we solve: "Trusted" third parties can't be trusted and criminals or hostile governments are free to launch man in the middle attacks. Extensive research in this area has been done by by Marlinspike, Dan Kaminsky and Mike Zusman which you really should read.
- Exploiting web application and business logic vulnerabilities of certificate authorities allow the generation of valid certificates for arbitrary domains you do not own.
- The number of entities allowed to issue certificates is now massive and not being effectively tracked– criminal organizations outright buy certificate authorities and print certificates for arbitrary domains they do not own.
- Do you trust the Chinese government not to snoop on your traffic? What about the United States government? Your browser trusts both– either of them can snoop on your "secure" HTTPS sessions.
- EV SSL is a joke.
- Who watches the watchers?
The whole SSL architecture is broken and cannot be safely relied upon. Any system of authentication which relies on a "trusted" third party that you have no dominion over is flawed. DNSSEC is only an incremental improvement with the same underlying flaw– I may trust the ICANN, ISC, NIST, NTIA, the Department of Homeland Security, or VeriSign more than the combined ineptitude and maliciousness of every current SSL CA, but I still don't trust them. The whole idea of a trust anchor is fallacious.
We set out to solve this problem in a way that can reconcile three realities of security:
- Users cannot effectively comprehend anything but password authentication. They don't understand key management, and the task of getting hundreds of thousands or millions of users to install a client certificate or generate a keypair (and not accidentally reveal the private key) is a Herculean task that few IT departments want to try.
- Users cannot be trusted to manually verify fingerprints. Seriously, they just won't. Even the ones that perceive themselves as sophisticated and security-conscious.
- The network is now many times more hostile and open to attack than the server.
So we had to create an authentication mechanism in which a user inputs only a username and password, but ends up with a session immune from man-in-the-middle attacks without the use of a trusted third party.
We looked at various authentication schemes. Of note was Livejournal's. Being the most popular blogging site in Russia, they got user auth details jacked so many times by shady spammers jacking routes with "legitimate" certs that they stopped transmitting the hash plaintext over the wire. They give a nonce to the client and the client hashes locally and then sends the hash to the server. The other source of inspiration was the Socialist Millionaire protocol, which Off-the-Record Messaging utilizes with a shared secret to verify cryptographic fingerprints.
In almost every scenario where security is mission critical, you already have a shared secret from the outset. When an enterprise user is given their new account, or when someone sets up online banking at their bank branch they are given a temporary password. A temporary password is a shared secret, and shared secrets may be leveraged to verify fingerprint information.
Here's how Clench works:
- Client connects to server and sends hello.
- Server sends hello back, along with its cert.
- Standard Diffie-Helman key exchange happens in SSL/TLS/SSH fashion. Initial handshake is finished, cypher spec is changed, now here comes the magic:
- Server sends client the nonce value [ Ticks since unix epoch + 16 bytes of random data ]
- Client sends userid/username to server.
- Client types in password, but password is not sent to server. Both sides generate a hash.
Client generates y, a hash of [ client password + server's public key, as client sees it + nonce from step 4 ]
Server generates x, a hash of [ client password + server's own public key + nonce from step 4 ]
- Client and server use a symmetric and fair zero-knowledge proof to verify that we both have the same hash without revealing the value of the hash to one another. Imagine a two pan scale, and a secret of a given weight of marbles in a bag. If we both place our bag of marbles on the pans at the same time, if they come to an equilibrium we will have verified our shared secret without revealing it to one another.
- Server picks random exponents a2 and a3
,sends client g2a = g1a2 and g3a = g1a3
- Client picks random exponents b2 and b3
,computes g2b = g1b2, g3b = g1b3
,g2 = g2ab2 and g3 = g3ab3, picks random exponent r, computes Pb3r and Qb = g1r g2y, sends server g2b, g3b, Pb and Qb
- Server computes g2 = g2ba2 and g3 = g3ba3, picks random exponent s, computes Pa = g3s and Qa = g1s g2x and Ra = (Qa / Qb)a3, sends client Pa, Qa and Ra
- Client
- Server
For more information on this step please see the excellent paper "A Fair and Efficient Solution to the Socialist Millionaires' Problem".
- Server picks random exponents a2 and a3
- Upon successful completion of the proof, the server allows the session to proceed.
This method of authentication avoids nearly all of the current pitfalls for current authentication schemes. Things that cannot be done against our authentication mechanism:
- Cracking a hash from the wire: No hash is revealed!
- Man in the middle attacks. Impossible– compared shared secret is incorporating the server's public key. If there's an attacker in the middle, client's hash value y will be built with the wrong public key and thus will fail zero-knowledge proof comparison.
- Replay attacks. Underlying hash for proof is not revealed, and nonced anyways.
- Brute force of Socialist Millionaire protocol with a preloaded Rainbow Table: This is doubly impossible.
- Even if (x – y) could be extrapolated, the nonce is built with 16 bytes of random data. At least 2-3 bytes of the ticks value are hard to predict, ending up with (18 + password length) bytes of random data results in rainbow table size that is unfeasible to build.
- (x – y) cannot be extrapolated by brute force, as a new nonce is built for every authentication attempt, and potentially meaningful data from (x – y) cannot be generated without multiple attempts on the same shared secret value.
This can be accomplished in either the session layer or the application layer– the latter allowing easy implementation atop current infrastructure with trivial changes to clients.
The roadmap from here.
SSH can be implemented much faster, it'd just need a PAM module.
Hey, wait a second, doesn't the passphrase have to be stored in plaintext or as an unsalted hash on the server?
Well, possibly yes. The perception of this as being an insurmountable flaw is largely the result of fallacious decisions in SysV in 1988. They were good decisions at the time due to the fact that it was ludicrously easy to break the security of a server then. However, the network has become far more hostile than the server. There are two major ways of ensuring the safety of a plaintext password or unsalted hash data store:
- The authenticating server needn't actually have the password in plaintext, it merely needs access to a more device that has it. A secure hashing device can be implemented on a PIC/Atmel/Xilinx– it's job is to generate the nonce, give it to the server with a cookie, then when the server responds back with a userid and the cookie it hashes together the nonce, the client's password (which only the secure device has access to) and the server's known public key, taken from a whitelist. It then passes the hash to the server. It is trivially easy to build a device in hardware which can only provide nonces, cookies and hashes and write new passwords without ever giving stored passwords up in plaintext, and disallows reprogramming to do anything otherwise. Or if not a hardware device, perhaps a grsec-hardened machine running managed code with no network stack exposed, doing a similar transaction raw over serial port or Infiniband. If my sole goal of a machine is to hash things and keep a file secure, I can confidently make it bulletproof without risk of compromise.
The potential implementations highlighted above are in development, and will be aired at the first opportunity (provided I evade unjust imprisonment, lol).
- Make your users make two passphrases– the first of which will be stored in plaintext, to assure no MitM, the second of which will be stored shadowed as normal in case of server's compromise. Telling grandma she needs two different passwords to use her bank account is a lot easier than teaching her to install a client certificate.
Hey, there's no way to tell the difference between an attempt at man-in-the-middle and a mistyped password!
With a user-specified password, no. If your initial shared secret has a checksum or LUN check in it, however, the client can notify the user of a potentially mistyped password.
Okay, I'm tired of reading your shit. Where's the codes?
Here. Enjoy, and know that a meatier paper is on its way (provided I evade unjust imprisonment long enough to do the peer review process for a journal or conference) if you want to read this in academic tripe format.


text:
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subset: commoncrawl


text:
|Biosequences .. Software .. Molbio soft .. Network News .. FTP
In article <487k1d$qdc at biovax.biobase.dk>, kjaer at biobase.dk (Svend Kjaer) writes: >Currently, I'm doing western blots using a phage displayed pool of scFv's >as the primary antibody. I test against the protein, that the phage were >selected against in the first place and to check specificity, also against >a bacterial cytosolic extract from the E.coli strain, TG-1. >What I see after development is a pattern of 11 proteins in the extract > recognized by the phage added. They are from 14 kDa to 40 kDa in size. > They are not a result of crossreactivity from the scFv's as they also appear > when I use helper phage as a negative control. It must then be a specific >interaction between the phage-body and some bacterial proteins. > >I know that thioredoxin is known to interact with the phage particle during >the assembly process, but I was wondering if anyone could help me with >other possible candidates for such interactions. > >References would be appreciated > >Thanks > >Svend


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New York, March 27, 2014--The Committee to Protect Journalists welcomes the release this week of at least eight imprisoned journalists in Turkey, but calls on Turkish authorities to scrap the charges against them and release all of the journalists jailed in the country.
"While we welcome Turkey's move to release journalists from prison, we reiterate that they should never have been jailed in the first place," said CPJ Executive Director Joel Simon. "As long as the charges are pending, and the threat of jail persists, the Turkish media will be deterred from independent and critical reporting."
The charges against the journalists have not been dropped, their lawyers told CPJ. The journalists were freed as their cases were transferred to criminal courts following the shutdown of Turkish Courts of Special Authority, courts that were established in 2005 to fight serious crimes like terrorism.
In a special session on Wednesday, the 3rd Court of Serious Crimes in Istanbul ordered six journalists to be freed, according to news reports. The journalists were being held on charges including membership in the banned Union of Communities in Kurdistan, or KCK, which the government has designated a terrorist group. The journalists include Nevin Erdemir, reporter and editor for the daily Özgür Gündem; Semiha Alankuş, translator and editor for Dicle News Agency/DİHA; Kenan Kırkaya, Ankara representative for DİHA; Mazlum Özdemir, a DİHA reporter; Hüseyin Deniz, reporter for the socialist daily Evrensel; and Mehmet Emin Yıldırım, editor-in-chief of the Kurdish daily Azadiya Welat. All of the journalists have been in prison since December 2011.
Sinan Zincir, a lawyer for a few of the journalists, told CPJ the journalists have been banned from foreign travel. Their next court date is scheduled for July 10. He said five other journalists remained in prison in connection with the case and it is not clear why.
In a separate case today, the 20th Court of Serious Crimes in Istanbul ordered the release pending trial of Veysel Şahin, editor for the bimonthly Tavır, and Yeliz Kılıç, reporter for the biweekly Yürüyüş, who have been imprisoned since January 2013. The journalists are accused of involvement in the outlawed Revolutionary People's Salvation Party/Front (DHKP/C).
Their lawyer, Evrim Deniz Karatana, told CPJ that the journalists had been freed but that the details surrounding the releases were not available. The charges have not been dropped.
Earlier this month, three other journalists held in connection with the KCK case were released. Dilek Demiral, former editor for Özgür Gündem, Sibel Güler, former editor for Özgür Gündem, and Ayşe Oyman, a reporter for DİHA, were freed on March 3, according to news reports.
Several journalists held in connection with the separate Ergenekon case were also released this month. Turhan Özlü, chief editor for the ultranationalist-leftist TV station Ulusal Kanal, was released from jail. Three others--Yalçın Küçük, opinion writer for Odatv; Deniz Yıldırım, chief editor of Aydınlık, and Merdan Yanardağ, chief editor of Yurt--were freed. Two other journalists--Tuncay Özkan, former owner of Kanal Biz and Kanaltürk TV stations, and Hikmet Çiçek, Ankara representative for Aydınlık--were also released, though CPJ has not been able to establish that their imprisonment was related to their work.
Turkey has been the world's leading jailer of journalists for the past two years, according to CPJ's annual prison census. Turkish authorities conflate the coverage of banned groups and the investigation of sensitive topics with outright terrorism or other anti-state activity, and make alarming use of detention prior to trial or verdict, CPJ research has found.
Separately today, Turkish authorities blocked YouTube. The Turkish Telecommunications authority TIB said it had taken "administrative measures" against the video-sharing website, according to news reports. The move came after a leaked voice recording was posted on the website in which Turkish officials were allegedly heard discussing possible intervention into neighboring Syria, the reports said. The measure follows the government's shutdown of Twitter on March 21.


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COLUMBUS, Ohio -- Ohio State University engineers are helping satellites form a clearer picture of water quality in the Great Lakes.
The study -- the first ever to rate the effectiveness of various computer models for monitoring the Great Lakes -- might also aid studies of global climate change.
As algae flourishes in the five freshwater lakes every summer, satellite images show the water changing color from blue to green, explained Carolyn Merry, professor of civil and environmental engineering and geodetic science.
When algae levels are too high, water takes on a foul taste and odor that isnt easily removed by traditional treatment methods. Some forms of algae, such as one called microcystis, are toxic when consumed in large quantities. Though it can be filtered out of drinking water, microcystis can kill fish and birds, and coastal communities often have to ban swimming and water skiing in the summer when the algae blooms.
Computer models enable scientists to measure the color of light reflected from the water to gauge how much algae is present in a lake, and where. The problem: all the available models of this type were originally designed for sea water, not lake water.
Theyve got it down pat for the ocean, Merry said of the various models developed by NASA and other agencies over the years. But lakes are shallower and have different water conditions that affect the wavelengths of light collected by the satellites, so we can get erroneous measurements.
Merry and masters degree student Raghavendra Mupparthy reported the results of an initial study of Lake Erie May 25 in Denver at the meeting of the American Society for Photogrammetry & Remote Sensing. They determined which four of the top ocean models may perform well for studies of the Great Lakes.
Most scientists look for evidence of climate change in the oceans rather than in lakes, but that may change in the future, the engineers said.
Lakes are important because they respond much faster to climate change than oceans do, Mupparthy said.
Erie is the warmest of the Great Lakes, the shallowest and richest in life, and has changed much in recent years. For instance, the lake has experienced a microcystis outbreak every summer since 1995. The warmer the temperature, the bigger the outbreak, Merry said.
Though lakeside towns routinely measure algae levels firsthand, satellite images give scientists a broader view of trends in the lakes.
If we want to really understand whats happening in Lake Erie, we can take these computer models and marry them to other data to get a more complete picture, Merry said.
The models could also apply to other large lakes and seas, such as the Mediterranean.
The key to proving the models valid, she said, is to compare them to actual measurements of algae in the water. Thats what she and Mupparthy did for Lake Erie, by collecting water samples from four sites in October 2000.
They compared the actual algae levels to the levels suggested by 17 different models, each using images of the lake taken by NASAs SeaStar spacecraft.
Model performance varied widely; one demonstrated an error of more than 250 percent, while several were off by less than one percent.
What set the top-performing models apart was how well they enabled the engineers to remove the interference of atmospheric molecules. Over the ocean, carbon dioxide, ozone, and humidity are fairly constant, but amounts of these molecules fluctuate dramatically over lakes depending on the weather and human activity.
The National Oceanic and Atmospheric Administrations Cooperative Institute for Limnology and Ecosystems Research funded this study. Merry and Mupparthy have applied for funding to collect water samples from more sites, with the hope of customizing a model for Lake Erie.
Contact: Carolyn Merry, 614-292-6889; firstname.lastname@example.com
Raghavendra Mupparthy, 614-688-4753; email@example.com
Written by Pam Frost Gorder, 614-292-9475; firstname.lastname@example.com


text:
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The right to the highest attainable standard of health is the internationally agreed objective of national health systems. The right covers universal access to health care and social factors governing the health of populations, such as access to safe and adequate drinking water, sanitation, food, and housing.
Prof Allyson Pollock and her colleagues undertake research and teaching intended to assist the realisation of these principles of social justice and public health, looking in particular at health systems research, trade, and pharmaceuticals. A strong emphasis is on developing critical analysis through education and research and through translating research findings into policy at the national and international level. The work is interdisciplinary, including epidemiology, law, statistics, economics, accounting, sociology, and anthropology.
Universal access to health care is the primary focus and in particular the means by which local and national systems redistribute resources across society by sharing the risks and costs of ill-health. The work includes the study of public private partnerships in health and long term care, pharmaceuticals, and medical research, and how public health interfaces with trade law and intellectual property agreements.
Local and global issues converge around, for instance, the social and economic aspects of clinical trials, how medicines are accessed, the estimation of the global burden of disease, and evidence underpinning access to medicines policies; the setting of health care priorities through the creation and use of clinical evidence; and the export of managed health care systems.


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An overview of the Sahel Humanitarian Response Plan 2014-1016
Sahel Hunger Crisis
20 Million People in Need
Erratic weather, failed crops, soaring food prices and violence complicate relief efforts for the 20 million people who are at risk of food insecurity.
"My Daughter Returns From Far Away, a True Miracle"
Read how a family in Niger overcame food insecurity.
Blogs From The Sahel
Visit our "Notes From The Field" blog for first-hand accounts of the Sahel hunger crisis and learn about the immediate and long-term relief CARE is providing.
What's happening in the Sahel?
June, 2014: According to the United Nations Food and Agriculture Organization, 18.7 million people in the Sahel region faced an extreme food crisis in 2012. The worst of the crisis was averted, but the risk of its return remains. Today, 20 million people in the region are at risk of food insecurity and 2.5 million of them need immediate lifesaving food assistance. An estimated 5 million children younger than 5 will suffer from malnutrion in 2014.
The ongoing food crisis in the Sahel region has been complicated by violence in Mali, which in turn has sent refugees fleeing the conflict into neighboring countries. More than 1 million people have fled from their homes in the Sahel and are now refugees or displaced within their own countries.
Compounding existing food insecurity, the recent combination of erratic rains, failed crops, soaring food prices and regional instability has left millions of people hungry. The recurrence of this food crisis has eroded the region's resilience and coping abilities and has devastated residents of the Sahel region who already suffered from chronic poverty before. Many never recovered from the 2012 food crisis and are unable to withstand another blow to their livelihoods.
The situation is most dire and continues to deteriorate in Mali due to conflict. In Mali alone, estimates report that about 4 million people need humanitarian assistance, and 496,000 children under 5 are at risk of malnutrition. Neighboring countries such as Niger and Chad are now faced with an influx of refugees from Mali and little resources to support them. In addition to food insecurity, diseases such as cholera and measles remain a constant risk. Floods and locust infestations continue to hinder successful food production.
The late arrival of rains, the low availability of cereal stocks in households, poor harvests and the failure of markets to function properly mean that people have not been able to recover since last year's hungry season. As a result, this year's food stocks are predicted to run out early. CARE is continuing to respond in Chad, Mali and Niger with both immediate relief and long-term solutions.
Keep learning:
How CARE works in emergencies
In 2011 alone, CARE reached 12 million people affected by natural disasters, conflict situations and other crises.
In emergencies, CARE is among the first to arrive and the last to leave. When it comes to responding to an emergency, timing is crucial.


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The UK's tabloids went into a major lather last year when comedienne, writer and actor Dawn French was snapped at the Galaxy Book Awards ceremony having obviously lost weight. "Dawn looks hot", said one red top. "It's a new dawn", another in Punsville quipped. "Her ex-husband Lenny Henry must be kicking himself now", said one television presenter – I cringed especially at that one. "Some people look drained when they lose a lot of weight, but she doesn't does she?" beamed another.
Let's get something straight here. Dawn French has always been generously proportioned and embraced her size; after all her autobiography is called Dear Fatty, so it's not as if the woman suffered from self-denial when she was heavier.
People – and the press – have always made a bigger deal (I do apologise – I seem to be going down the pun route myself here) of it than she has, despite her well-publicised adoration of chocolate and flying the flag in many ways for full figured women out there. She always said plus size women can be just as sexy as thinner ones. And she's right.
Dawn, from what I can make out, hasn't been on a diet as such, just started to eat more healthily and take exercise. Both are rational sensible things to do. She's lost a few stone by this method and good on her, I say. I understand her weight loss being the focus of attention – she looks wonderful, but then she always did. What I can't comprehend is why fingers are being pointed gleefully and nastily at her.
"No one can be that happy being so fat", said one commentator. Another paper pointed out the 'downside' of losing weight – loose skin. When I read that, I imagined some paparazzo desperately shimmying up the drainpipe outside her bathroom trying to get a shot of her in the all together just to prove the point. Some have even offered the view that Dawn French has let curvier women down, that she has failed us in some way. No she hasn't.
And neither have Nigella Lawson and Ruth Jones (who played Nessa in the sitcom Gavin & Stacey). Both have lost weight over the last year, the latter in particular will always be a full figured woman – and looks fabulous with it. The woman gets it in the neck when she's bigger and when she's slimmer as well. She can't seem to win. It's judgemental and makes all women feel bad about themselves.
Dawn French is still her beautiful curvaceous self. Hardly a size zero and even if she was she'd still be gorgeous. I've got news for people having a pop at her – women come in all shapes and sizes, it's nothing new. Hardly a revelation, you'd think. Dawn looks healthy and happy, which is the best way to be.


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VATICAN CITY (Reuters) - Pope Francis is to set up a special committee to help protect children against sexual abuse within the Catholic Church, the archbishop of Boston, Cardinal Sean Patrick O'Malley, said on Thursday.
The move is Francis' first major step to address the crisis that has discredited the church, in the face of charges the Vatican has not done enough to protect children or make amends.
"The Holy Father has decided to establish a specific commission for the protection of children," O'Malley told reporters.
"The commission will be able to advise the Holy Father about the protection of children and pastoral care of victims of abuse."
Cases of abuse by clergy have forced the church to pay hundreds of millions of dollars in compensation worldwide, bankrupting a string of dioceses in the United States.
The precise mission and make-up of the committee is not yet decided but its role is likely to involve forming guidelines for child protection, improving screening of priests, examining ways to help victims and coordinating cooperation with civil authorities over abuse cases, O'Malley said.
It is also expected to examine ways to help communities affected by abuse and provide mental health care to victims.
The proposal of a child protection committee was first discussed on Wednesday and Francis immediately approved the suggestion when told of it on Thursday, meaning it could be immediately announced, O'Malley said.
The Vatican was criticised for refusing to share details of its internal investigations into abuse cases earlier this week and some commentators have faulted the first Latin American pope for not addressing the inherited abuse scandal.
O'Malley pioneered a pro-active response to the issue by publishing a database of Boston clergy accused of sexual abuse of minors online in 2011.
His announcement came on the third and final day of a series of closed-door meetings between Pope Francis and a special commission of eight cardinals who are discussing the Vatican's troubled administration.
The group, named a month after the pope's election, aims to push through reforms of the top-heavy administration and tackle festering scandals like child sex abuse by priests. It will next meet from February 17-19, O'Malley said.
In January the Holy See will be questioned by the United Nations Committee on the Rights of the Child on its response to the abuse crisis in relation to the 1990 U.N. Convention on the Rights of the Child, which the Holy See has signed.
Reporting by Naomi O'Leary; Editing by Andrew Roche


text: Parts & Supplies view other parts Carpet Tool for Hard Floor Expert Canister Vacuums | 1602089 $12.86 Add to cart Notify me when this item is in stock! This item is currently unavailable. Enter your email address and we'll notify you when it's available for purchase. submit Change Whoops! Something went wrong while saving your changes. Please try again later! Incorrect email format. Please make sure that there are no blank spaces at the beginning or end of your email address, and that you haven't included any invalid characters such as +. Part #: 1602089 Description: Carpet Tool for Hard Floor Expert Canister Vacuums - Series 1161 & 1547. This part works with: View Products This part works with the following products: Hard Floor Expert® Deluxe Canister Vacuum | 1161 Model Shown: 1161 Hard Floor Expert® Cordless Canister Vacuum | 2001 Model Shown: 2001 Similar Models: 2001A Hard Floor Expert® Canister Vacuum | 1547 Model Shown: 1547 Rewards Points: what's this? What is the Rewards Program? Collect rewards points to earn discounts and free shipping on future purchases. Learn more Read rules and regulations 13 Video And Image Gallery


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Clinical Trials
HIV Levels in Cerebrospinal Fluid and Brain Function in Patients Receiving Anti-HIV Drugs
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Neurological Disorders and Stroke (NINDS)
Neurologic AIDS Research Consortium (NARC)
Information provided by (Responsible Party)
National Institute of Allergy and Infectious Diseases (NIAID)
First received: November 2, 1999
Last updated: July 28, 2008
Last Verified: May 2006
History of Changes
The purpose of this study is to see whether anti-HIV drugs that reduce HIV in the blood also
reduce HIV in the cerebrospinal fluid (CSF). CSF is the fluid found around the brain and
spinal cord. This study also looks at whether reducing HIV in the CSF can help protect brain
HIV can be detected in the brain and CSF early in HIV disease. Anti-HIV drugs probably reduce HIV in the CSF. This may be important because other studies have suggested high CSF HIV levels may lead to some loss of brain function.
Cognitive Disorders
HIV Infections
|Study Type:
|Official Title:
|Cerebrospinal Fluid Human Immunodeficiency Virus-1 (HIV-1) and Cognitive Function in Individuals Receiving Potent Antiretroviral Therapy
Further study details as provided by National Institute of Allergy and Infectious Diseases (NIAID):
Detailed Description:
HIV-1 RNA emerges in CSF early in the course of HIV disease. Studies have shown that high
levels of HIV-1 RNA in CSF correlate with increased severity of dementia and worsened
performance on neuropsychological tests. While combination antiretroviral treatments are
potent suppressors of HIV-1 replication in plasma, the extent to which these treatments
suppress viral replication in CSF is unknown. A few studies suggest that antiretroviral
treatments can reduce HIV-1 RNA in CSF. However, since CSF is isolated from peripheral immune
responses to HIV and antiretroviral treatment may not readily penetrate the compartment,
researchers hypothesize the remaining virus will overcome the antiretroviral treatment to
achieve high levels of viral replication again. This virologic failure is likely accompanied
by decreased cognitive function. It is therefore critical to determine the ability of
antiretroviral treatments to control HIV-1 replication in the CSF and the durability of that
viral suppression.
Patients enrolling in one of several AACTG-sponsored potent antiretroviral therapy trials (a "parent" trial) may enter this study. [AS PER AMENDMENT 06/06/00: Patients already enrolled in an AACTG-sponsored study who are changing treatment due to virologic failure may also enter this study.] [AS PER AMENDMENT 11/15/01: Patients starting a new potent antiretroviral regimen as part of their clinical care, enrolling in a potent antiretroviral treatment trial, or changing potent antiretroviral therapy in clinical care or in an ongoing antiretroviral treatment trial because of virologic failure may enter this study.] Patients receive no treatment but undergo various procedures aimed at characterizing the effects of antiretroviral therapies on CSF viral load and cognitive function. Procedures include: 1) venipuncture to measure plasma HIV-1 RNA and DNA levels, CD4+ T cell count, and cytokine and immune activation markers associated with HIV-1 neurological disorders; 2) neuropsychological examinations to measure cognitive function; and 3) lumbar punctures to obtain CSF samples, which are used to determine the pharmacokinetics of antiretroviral agents in CSF and to determine levels of blood cells, cytokine and immune activation markers, and HIV-1 RNA and DNA. An entry visit must occur before initiating potent antiretroviral therapy in the parent trial [AS PER AMENDMENT 06/06/00: or before changing the antiretroviral regimen due to virologic failure in an ongoing trial]. [AS PER AMENDMENT 11/15/01: Patients are registered before initiating a new potent antiretroviral regimen.] Subsequent visits occur within 21 days prior to each lumbar puncture and at Weeks 24 and 52. If evaluations, procedures, or assays for a given patient's parent trial [AS PER AMENDMENT 11/15/01: for any coenrollment AACTG study] occur at the times specified in this study, they are not duplicated for this study. Other visits may occur when a patient changes antiretroviral treatment or discontinues a parent trial [AS PER AMENDMENT 11/15/01: discontinues a potent antiretroviral therapy].
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
- Are HIV-positive.
- Have levels of CD4 cells (immune cells that fight infection) less than 200 cells/mm3 and viral loads (level of HIV in the blood) greater than 2,000 copies/ml or viral loads greater than 50,000 copies/ml and any CD4 cell levels.
- Are either: 1) starting a new potent antiretroviral therapy for HIV; 2) enrolling in a potent antiretroviral trial; or 3) currently participating in an ongoing antiretroviral trial or in clinical care and will be changing treatment due to treatment failure. The entry visit for ACTG 736 must occur before starting the treatment or before changing to the new treatment. (This study has been changed to include patients who have changed treatment due to treatment failure and those who are starting a new anti-HIV regimen.)
- Have an infection or cancer in the brain or certain diseases of the brain or nervous system.
- Have a serious psychiatric illness (such as schizophrenia or severe depression).
- Have completed treatment for a significant infection within 4 weeks of beginning the study (but certain drugs that fight infection are allowed on this study).
- Are taking drugs to prevent or dissolve blood clots.
- Abuse drugs or alcohol.
Exclusion Criteria
Contacts and LocationsChoosing to participate in a study is an important personal decision.Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001103
Locations Show More
|United States, California
|Willow Clinic
|Menlo Park, California, United States, 94025
|Univ of California / San Diego Treatment Ctr
|San Diego, California, United States, 921036325
|San Francisco Gen Hosp
|San Francisco, California, United States, 941102859
|San Mateo AIDS Program / Stanford Univ
|Stanford, California, United States, 943055107
|Stanford Univ Med Ctr
|Stanford, California, United States, 943055107
|United States, Colorado
|Univ of Colorado Health Sciences Ctr
|Denver, Colorado, United States, 80262
|United States, Hawaii
|Univ of Hawaii
|HonolulU, Hawaii, United States, 96816-2396
|United States, Illinois
|Northwestern Univ Med School
|Chicago, Illinois, United States, 60611
|United States, Maryland
|Johns Hopkins Hosp
|Baltimore, Maryland, United States, 21287
|United States, New York
|Beth Israel Med Ctr
|New York, New York, United States, 10003
|Bellevue Hosp / New York Univ Med Ctr
|New York, New York, United States, 10016
|Mount Sinai Med Ctr
|New York, New York, United States, 10029
|Columbia Presbyterian Med Ctr
|New York, New York, United States, 10032
|Univ of Rochester Medical Center
|Rochester, New York, United States, 14642
|United States, Ohio
|Univ of Cincinnati
|Cincinnati, Ohio, United States, 452670405
|Case Western Reserve Univ
|Cleveland, Ohio, United States, 44106
|MetroHealth Med Ctr
|Cleveland, Ohio, United States, 441091998
|Ohio State Univ Hosp Clinic
|Columbus, Ohio, United States, 432101228
|United States, Pennsylvania
|Univ of Pennsylvania at Philadelphia
|Philadelphia, Pennsylvania, United States, 19104
|Univ of Pittsburgh
|Pittsburgh, Pennsylvania, United States, 15213
|United States, Rhode Island
|Miriam Hosp / Brown Univ
|Providence, Rhode Island, United States, 02906
|United States, South Carolina
|Julio Arroyo
|West Columbia, South Carolina, United States, 29169
|United States, Tennessee
|Comprehensive Care Clinic
|Nashville, Tennessee, United States, 37203
|United States, Texas
|Univ of Texas, Southwestern Med Ctr of Dallas
|Dallas, Texas, United States, 75390
|United States, Washington
|Univ of Washington
|Seattle, Washington, United States, 98104
|Puerto Rico
|Univ of Puerto Rico
|San Juan, Puerto Rico, 009365067
Sponsors and CollaboratorsNational Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Neurological Disorders and Stroke (NINDS)
Neurologic AIDS Research Consortium (NARC)
|Study Chair:
|Christina Marra, MD
|University of Washington
|Study Chair:
|Kevin Robertson, PhD
|University of North Carolina, Chapel Hill
More Information
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT00001103 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|July 28, 2008
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):Neuropsychological Tests
RNA, Viral
Anti-HIV Agents
Viral Load
Additional relevant MeSH terms:
Cognition Disorders
ClinicalTrials.gov processed this data on March 27, 2020
This information is provided by ClinicalTrials.gov.


text:
Headaches are a very common problem. People of all ages get headaches from time to time. They can cause unbearable pain along with nausea and, at times, vomiting.
Common causes of headaches include stress, tension, restlessness, sinus problems, migraines, lack of sleep and dehydration.
Many people reach for over-the-counter medicines to get rid of their headaches. However, you can get instant pain relief using some easy and natural home remedies.
For example, gently pressing the webbed area between your thumb and index finger for about a minute can help ease your headache. Repeat on your other hand as well.
Here are some natural ways to get rid of a headache fast.
If the cause of your headache is dehydration, you can easily get relief from the pain by rehydrating your body.
Simply drink a glass of water at the first sign of a headache and continue taking small sips throughout the day.
Along with water, you can have sports drinks. The electrolytes present in sports drinks can treat headaches caused by tension and dehydration.
When suffering from a headache, stay away from drinks like alcohol that can dehydrate your body.
Ice Pack
Placing a cold compress like an ice pack on your forehead will numb the pain, help shrink the blood vessels and improve circulation to the area. This particular remedy works well for headaches due to stress or sinus problems.
Wrap some ice cubes or crushed ice in a thin towel. Hold it against your forehead for a few minutes. A bag of frozen vegetables can also serve as an icepack. Never apply ice directly on your skin as it can damage the skin.
Alternatively, apply a cold cloth on your head and temples for 10 minutes and repeat the process for some time until you get relief.
Hot Water
Applying heat on the back of your neck can relieve headaches caused by stress. Heat relaxes tense muscles, thus alleviating the throbbing pain.
Simply apply a hot water bag to the back of your neck or take a hot shower directing the water onto the back of your neck.
Another option is to fill a tub with bearable hot water and put your hands in it for 10 to 15 minutes. This will improve blood circulation and thus give you relief from the headache.
If you suffer from chronic headaches, you can dip your legs in a bucket filled with hot water for 10 minutes before going to bed.
Lemon is a very effective and powerful ingredient to treat headache because it is refreshing and relaxing. Plus, it helps maintain the acid-alkaline balance in the body.
Drinking warm water mixed with juice squeezed from one-half of a lemon will reduce the intensity of a headache. This particular remedy is beneficial for headaches caused by gas in the stomach.
Another option is to apply lemon crusts, pounded into a paste, on your forehead to immediately relieve pain.
Both apples and apple cider vinegar can be used to fight off a headache. They help restore the acid-alkaline balance in the body. Furthermore, simply the smell of green apples can help reduce migraine headaches.
When you wake up in the morning with a headache, eat a piece of apple sprinkled with some salt. Then drink some warm water.
Alternatively, fill a large bowl with steaming hot water and add 3 to 4 tablespoons of apple cider vinegar to it. Hold a towel over your head and take in the steam for 10 to 15 minutes.
Another option is to add 2 teaspoons of some apple cider vinegar to a glass of water. You can also add a little honey and lemon juice. Drink it 2 or 3 times a day.
Peppermint has calming and soothing properties that can help treat headaches.
You can make an herbal tea by adding 1 teaspoon of dried peppermint to a cup of boiling water. Cover and let it steep for 10 minutes. Strain and add some honey to sweeten it. Sip the tea slowly.
You can also use peppermint oil to gently massage your temples, jaw and the back of your neck for instant pain relief.
In addition, inhaling the soothing aroma of peppermint steam can ease headache as well as accompanying symptoms, such as nausea and vomiting.
Ginger has anti-inflammatory properties that can help ease headache pain. It also helps relax the blood vessels in the head, reduces swelling in the brain and activates natural opiates in the brain that help lessen the pain.
Simply drink ginger tea up to 3 times a day to reduce inflammation in the body and alleviate headache pain. It is important to start at the onset of the headache so the ginger can act quickly.
Aches and Pain Gel
The Aches and Pain Gel in the Natural Balance range, applied to your forehead and side of the forehead can help to alleviate headaches in a jiffy. The gel contains essential oils which penetrate the skin for fast, effective relief of pain.


text:
Find out more about our new Mix 'n' Match Classic Flavours and Colours
A selection of our full Popup Corn Colour range and Classic Flavours range from the top bait flavourists, as used by many top anglers..... here for you to choose to mix to create your very individual custom color and flavour combination.
New for 2016 our Popup Sweetcorn
and 15mm Eternal Boilies available
in a 'Washed Out' colour range
Three great new confectionery
flavour additions to our
Classic Flavour Corn Range.
Find out more about our new ET13 Classic
CC Moore Flavour's Pop Up Sweetcorn.
A selection of Classic CC
Moore flavours .....Frankfurter, Salmon,Chocolate Malt,
Blackcurrant, Belachan, Plum and Green Lipped Mussel.
A favourite with continental
angler's, Lupin beans are now
gaining popularity in the UK
with carp and specialist angler's
looking to gain an edge!
Our Large Pop up corn offers greater buoyancy and
is ideal for tipping larger size boilies
Available in Yellow (Tutti Fruity) White (Pineapple)
Unflavoured Yellow and White.
ET72 Zig Beetles are now flying of the shelf
So get round to your local tackle dealers early
as they will be 'landing' in one near you shortly.....
Used by top specialists Ian Welch & Alan Stagg
Enterprise Pellet Skins will make fishing pellets
simpler and offer the chance to load them with paste...
Used by Frank Warwick
Enterprise 15mm Half Boilies help bridge the gap
between an imitation and a real food source bait...
Find out more about this new Soft buoyant imitation corn impregnated with attractors, plus integrated hair stop system. .....
Also available in a Sinking version
Find out more about our new Imitation Baits Selection Boxes, Carp Box, Popup Corn Box and Coarse Box.
A selection of our best Imitation Baits as used by many top anglers including Ian Welch, Joe Morgan, Frank Warwick, Alan Stagg, Julian Cundiff and Danny Fairbrass of Korda Developments.....all packaged in in dedicated clam shell pack.
Welcome to the new Enterprise Tackle website. We are the U.K's leading manufacturer of imitation baits and make all our baits here in the U.K. We were the first company to produce the now legendary Popup Sweetcorn, and our baits are now widely used by many of Britain's and Europe's top carp and specialist angler's. Over the years as our range has grown many thousands of specimen carp, bream and tench have fallen to our baits, including British record carp, grass carp and bream.
However as with most successful products there are those that choose to copy, and now many of the major companies produce copies of our products, most made in the far east. Don't be fooled into thinking that these baits will catch you more fish, just because they come from a big name brand, they won't. All our baits are impregnated with our special mix of attractants that leach out attracting fish. This combined with our vast knowledge of plastics and attention to detail, is the reason we believe we are arguably the market leader in imitation baits, with our baits consistently out fishing those of our competitors.
As well as our imitation baits we also produce an innovative range of terminal tackle and accessories. Items such as our nightlite adaptors for quiver and rod tips, adjuster stops, protect-a-beads and snag safe lead clips, are now standard kit for thousands of chub and barbel angler's. Unfortunately few shops choose to stock many of our products other than our most popular imitation baits, so we do offer you opportunity to purchase direct from us. We would however suggest you try your local stockist first, as many will order items in if asked.
Finally I would like to mention and thank our consultants who continue to help us test and develop new products, and promote us through their media and magazine work. On the carp side we have Frank Warwick, Myles Gascoyne, Julian Cundiff and Antony Ballard, and on the coarse/specialist side there's Alan Stagg.
Enterprise Tackle celebrates 20 years of imitation bait this year - having produced more than 25 million pieces of fake sweetcorn!
Whilst we are providing the opportunity for you to purchase our
products from the website, Enterprise Tackle would ask that you
support your local tackle shops and buy our goods from them.
If you are unable to purchase what you need then please do use
our online shop or ask the shop to stock the item!


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text:
28 best white bedroom ideas how to decorate a white bedroom 1
28 best white bedroom ideas how to decorate a white bedroom 1- comfortable bedrooms and beautiful is certainly a dream for everyone. Comfortable bedrooms will make your rest comfortable so that it becomes fresh in the morning. In addition, the comfortable bedrooms can also support activities in your room. As you know, when this room is not only used as a place to rest at night only. Many people have made it as a place to learn, work, and relax. Comfortable rooms don't have to with the room size. not everyone has the room size. The difficulty of finding a broad settlement land, certainly makes a lot of people use the concept of minimalist house home land with a size that is not too broad. Because the House didn't land too broad of course makes part of the room was also not too spacious including the bedroom. But that does not mean you can't get a room sleeping rooms though with a narrow size. Well here are some tips that you can use to design the bedroom with a size of 2 × 3 m which has a minimalist and modern look.
One of the most simple tips for minimalist bedroom interior design is to avoid the presence of crib mattress as a bed frame of your bed. These tips are very simple and effective way to make the room appear to be extensive. When you put the crib in his room, it will make the room becomes suffocating and disturb you. You can use the concept of minimalist rooms like Japanese style that do not use the crib in their bedroom. They directly use the floor as the base pedestal bed them. The savings in this room, you can do so you can put other more useful furniture in the bedroom. as in the picture 28 best white bedroom ideas how to decorate a white bedroom 1 the furniture arranged properly. The other thing that can be a minimalist room interior ideas is to use spring bed floor as the base of the bed. As mentioned earlier, using spring bed floor directly as a pedestal bed then you can save room bedroom area. The concept of this floor bed can you design with the best possible which can make the room look into minimalism with a modern design. The feel of the room like this concept often used in Japanese homes.
To make room, minimalist you become comfortable, you can use the cabinets paste that can save room. The closet is the furniture that is in the room. A closet is usually in use as a place of storage of clothes, books, and more. However, using a closet as a minimalist bedroom interior furniture is certainly going to make the room becomes narrow. to overcome this problem, you can use the cabinets models affixed on the walls of the room the bedroom as one of alternative solutions. But to be optimized again, you can use multi function furniture, for example, the cabinets are combined with tables so more save room your bedroom. It's been a lot of multi function furniture is sold over the counter. The idea is fairly simple but it can make the room look becomes more widespread. so tips on creating minimalist bed room to be comfortable.You can download 28 best white bedroom ideas how to decorate a white bedroom 1 in your computer by clicking resolution image in Download by size:. Don't forget to rate and comment if you interest with this wallpaper.


text:
Coral Chev
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text:
Non-profit corporation working to build a grass roots secular community in Texas and beyond. The TFC holds a state wide convention once a year featuring national and local speakers, music, family activities, debates, disucssion and networking.
Website: http://wwwtexasfreethoughtconvention.com
Location: Texas
Members: 19
Latest Activity: Feb 4
Started by Steph S.. Last reply by Steph S. Oct 21, 2011. 1 Reply 0 Likes
This was incredible! Im going to write about my experience soon! Way too impactful not to...
I'm really ticked off now…..BIG TIME!
Last night I expected all the "rapture" yahoo's to be gone. All I expected to find was a bunch
of clothes, empty house, apartments, mobile homes and the like. Cars just left on the street with the keys in them.
I had planned to go out looting. I was gonna clean up with the cash they left behind, their valuables, jewels, precious metals, silverware, electronics and the such.
I even had a SHOPPING LIST!
And I had a list of things my friends wanted….. Of course, there were some prescription meds certain friends wanted me to get for them…. And some things that weren't prescription as well….
It only goes to show you, you can't trust these "rapture" clowns….
Sigh……..back to clipping coupons….
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The authors are research scientists and engineers for Intel Labs. They can be contacted at [email protected], [email protected], [email protected], and [email protected], respectively. Copyright (c) 2009 Intel Corporation. All rights reserved.
As of January 2009, it is estimated that the Internet connects 625 million hosts. Every second, vast amounts of information are exchanged amongst these millions of computers. These data contain public and private information, which is often confidential and needs to be protected. Security protocols for safeguarding information are routinely used in banking and e-commerce. Private information, however, has not been protected on the Internet in general. Examples of private information (beyond banking and e-commerce data) include personal e-mail, instant messages, presence, location, streamed video, search queries, and interactions on a wide variety of on-line social networks. The reason for this neglect is primarily economic. Security protocols rely on cryptography, and as such are compute-resource-intensive. As a result, securing private information requires that an on-line service provider invest heavily in computation resources. In this article we present new technologies that can reduce the cost of on-line secure communications, thus making it a viable option for a large number of services.
A lot of private information is transmitted over the HTTP in an insecure manner. HTTP exists in the application layer of the TCP/IP protocol stack. The Secure Sockets Layer (SSL) and its successor, Transport Layer Security (TLS) are security technologies applied to the same layer. In this article, we specifically refer to SSL/TLS over the HTTP application layer, known as HTTPS. The introduction of HTTPS significantly increases the cost of processing traffic for web-service providers, due to the fact that it is not possible for previous-generation, web-server hardware to process high-volume HTTPS traffic with all the added cryptographic overhead. In order to process this high-volume traffic, a web-service provider has to invest in expensive end-point SSL/TLS acceleration devices. This added cost makes HTTPS a selective or premium choice among web-service providers. Consequently, a large amount of private information is transmitted over the web in an insecure manner and can, therefore, be intercepted or modified en route. In this article we provide a solution to this problem by presenting new technologies and results that show that it is now possible to use general-purpose hardware for high-volume HTTPS traffic.
The motivation behind our research is primarily to enable widespread use of, and access to, HTTPS. It is important for service providers and users to be able to trust each other for their mutual benefit. An important aspect of the trust comes from knowing that private communications are kept confidential and adhere to the policies established between providers and users. Users need to be educated and informed about the benefits of HTTPS for privacy in on-line communications. Providers need to adopt ubiquitous HTTPS offerings to ensure that they hold up their end of the deal. Enabling HTTPS without expensive investment is important in creating such a partnership.
HTTPS provides an end-to-end solution to data privacy and authenticity. This end-to-end solution ensures that when users transmit information from their device to a provider, the information cannot be seen by man-in-the-middle spyware. This is important due to the fact that packets travel over untrusted networks all the time in the Internet. Although most routing devices are hidden from direct observation, they are not impervious to motivated eavesdroppers. Even more observable are the publicly accessible wireless access points that are in use all over the world. These access points broadcast information to all devices managed by them. If there is not an end-to-end solution for security, these communications can be easily observed by network neighbors. There are other solutions to the security problem, such as Layer 3 Virtual Private Networks (VPNs), but VPNs are typically limited to networks where users communicate with other users within a centrally managed network; that is, having multiple users but a single provider. In such cases, the network provider already has strict policies about data privacy and security that are communicated to users via training. For example, e-mails within an enterprise are often allowed only over the enterprise-managed VPN. For the larger Internet, users connect across the networks of multiple providers. In addition, in recent years we have seen a reduction in the use of a wide variety of communication protocols (for example, FTP) in favor of the HTTP protocol. In this environment, HTTPS is the most viable solution to enabling private and secure communications amongst the large and growing numbers of users and providers.
Future applications of HTTPS may include widespread e-mail encryption, secure video streaming, secure instant messaging and encrypted web searching. These are a few of the many applications of HTTPS that are not widely used today. Moreover, with each passing year, users are putting more of their personal and private information on-line. Cloud computing enables them to access their information across all their devices everywhere. We believe that it is inevitable that users will demand HTTPS support from their providers for all their communications. Being prepared for that day led us to research and develop the technologies described in this article. We envision that with these advancements, every HTTP-based communication made by every device today will be HTTPS-based in the near future. We refer to this as "https://everywhere!".
Anatomy of a Secure Sockets Layer Session
Secure sockets layer (SSL) (later versions known as "Transport Layer Security", TLS) includes a handshake phase and a cryptographic data exchange phase. The overall SSL handshake is shown in Figure 1. In our diagram, in phase 1, the handshake begins when a client sends a server a list of algorithms the client is willing to support as well as a random number used as input to the key generation process.
In phase 2, the server chooses a cipher and sends it back, along with a certificate containing the server's public key. The certificate proves the server's identity. We note that the domain name of the server is also verified via the certificate (which helps eliminate phishing sites) and demonstrates to the user they are talking with the correct server/service. In addition, the server provides a second random number that is used as part of the key generation process. In phase 3, the client verifies the server's certificate and extracts the server's public key. The client then generates a random secret string called a pre-master secret and encrypts it by using the server's public key. The pre-master secret is sent to the server. In phase 4, the server decrypts the pre-master secret by using RSA. This is one of the most compute-intensive parts of the SSL transaction on the server. The client and server then independently compute their session keys by using the pre-master secret to apply a procedure called a key derivation function (KDF) twice. In phases 5 and 6, the SSL handshake phase ends with the communicating parties sending authentication codes to each other, computed on all original handshake messages.
In SSL, the data are transferred by using a record protocol. The record protocol breaks a data stream into a series of fragments, each of which is independently protected and transmitted. In other words, in IPsec, protection is supported on an IP-packet-by-IP-packet basis, whereas in SSL, protection is supported on a fragment-by-fragment basis. Before a fragment is transmitted, it is protected against attacks by the calculation of a message authentication code on the fragment. The fragment's authentication code is appended to the fragment, thereby forming a payload that is encrypted by using the cipher selected by the server. Finally, a record header is added to the payload. The concatenated header and encrypted payload are referred to as a "record".
A secure web server is clearly a memory-intensive application. For an SSL connection, the most significant type of overhead is the one related to cryptography. This includes the operations of encrypting packets with a symmetric key, providing message authentication support, and setting up the session by using RSA, as mentioned previously. In the section that follows, we describe in more detail two encryption algorithms that we accelerate with technologies described in this article: the Advanced Encryption Standard (AES) and Rivest Shamir Adleman (RSA).


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The City Club Forum
The City Club of Cleveland firmly believes in the free expression of all ideas and the benefits of an open exchange. It is non-partisan and does not take positions on issues. All speakers must answer unfiltered, unrehearsed questions directly from the audience.
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It is all about the topping.
I love crumb cake. I am pretty sure it has to do with the fact that my mom would make it when I was little. It also fits quite nicely with my love of cinnamon. This crumb cake is not just an ordinary crumb cake, because it is a New York Style Crumb Cake. Anybody of you from New York or the northeast will know, that to be a a New York crumb cake there needs to be significant crumb topping. In fact, this cake may be a little shy on the topping for some real New Yorkers. I am sure if you tasted it though, you would forgive the fact that the crumb topping should probably have been a little thickener because this cake is delicious!
New York Crumb Cake
recipe from Baked Explorations by Matt Lewis & Renalto Poliafito
Crumb Topping
1 cup packed dark brown sugar
1/2 cup granulated sugar
1/2 teaspoon salt
1 1/2 tablespoons cinnamon
1 cup (2 sticks) unsalted butter, melted (and still warm)
2 1/2 cups all-purpose flour
2 1/2 cups all-purpose flour
3/4 teaspoon baking powder
1 teaspoon baking soda
1/2 teaspoon salt
12 tablespoons (1 1/2 sticks) unsalted butter, at room temperature
1 1/2 cups sugar
2 large eggs, at room temperature
1 1/4 cups sour cream, at room temperature
1 teaspoon vanilla extract
Preheat oven to 350 degrees Fahrenheit. Spray a 9x13 baking pan with cooking spray.
To make the crumb topping: Whisk the flour, brown sugar, granulated sugar, salt and cinnamon together in a large bowl. Add the melted butter and whisk to combine. Use a rubber spatula to fold in the flour.
To make the cake: In a medium bowl, whisk together the flour, baking powder, baking soda, and salt. In the bowl of a stand mixer fitted with the paddle attachment, cream the butter and sugar together on medium speed until light and fluffy, about 2-3 minutes. Beat in the eggs, one at a time, letting the first incorporate fully before adding the second. Scrape down the sides of the bowl and beat for an additional 30 seconds. Add the sour cream and vanilla to the mixer and beat until just incorporated. Finally, add the flour mixture in thirds, beating just until combined.
Transfer the batter to the prepared baking pan. The batter will be thick, use a spatula to spread it evenly. Pick up the crumb topping by handfuls, and break off chunks, scattering them over the top of the batter. Use all of the topping.
Bake for 45-55 minutes (rotating the pan at 15 minute intervals), or until a toothpick inserted in the center of the cake comes out clean. Let the cake cool in the pan for at least 30 minutes before serving.
p.s. Happy Father's Day Dad and Happy Father to-be Day Zack. I love you guys!


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The Ferrari 365 GTB/4 Daytona is one of the most iconic cars to ever leave the fabled gates of Maranello. From the long hood to the short rear, everything about the design just screams sex.
That's why it always sucks to see one in a tree. Especially the ulta-rare convertible version worth more than $600,000.
Apparently, the driver of this one says that the brakes failed on his car. This is the second Ferrari brake failure in a week, except this one resulted in slightly more expensive damage.
The 39-year-old driver and his 42-year-old car suffered very different fates. The driver walked away. The car definitely did not. There was also a passenger who was hospitalized with minor injuries.
Ferrari's Daytona Spyder is one of the white whales of the auto world. Since there were only 122 built, an original Spyder is basically a unicorn.
This car has to be saved, no matter the cost. They have the technology.
(Hat Tip to Alexander!)


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Winsupply is now offering a company-wide, commercial charge card that may be used at any of the Winsupply Company's across the country. For example, it can be used at Winnelson, Winwater, Winlectric, etc. Though this is a credit card, it is considered a month-to-month charge account. This means that the balance is to be paid off at the end of each month. A bonus of the card is that it is not needed to make a purchase at one of our stores. Once you sign up, your information is saved in our computers, so all you need to make a purchase is your name. To fill out an application, please click on the resources tab and then the credit page tab.
Apply today for our commercial charge program and you'll receive:


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Designer Spotlight: Meg Myers
9 comments:
- AnonymousFebruary 28, 2012 at 12:04 PM
Must ask---where in So. Colorado? Wet Mountain Valley or so? Those mtns look AWFULLY familiar. I'm in Alamosa & think yours are the other side.ReplyDelete
I'm ready to seeeeeee the lace design.
Our towns are football rivals! I grew up in Monte Vista, back when there was only one drive-in and Muddpuppy's was the cool place to be (except on weekends, when we ended up in Almosa anyway). The photo is of Crestone from the west side of Monte.ReplyDelete
Very nice interview and great inspirations!! Keep up the good work.ReplyDelete
- AllisonMarch 1, 2012 at 4:12 PM
I'm pretty sure you used to work at my LYS! I have been recognizing you in these web-letters, and I am so happy for your success!ReplyDelete
Enjoyed reading your 'bio', Meg.ReplyDelete
I'm in awe of your creative talent.
Have you completed (& posted, somewhere) the lacey design (above)? I have been looking all over for it. You indicated it was complete for the "Web Letter," but which Web Letter? Either I'm not looking in the right place or???ReplyDelete
Am new (VERY) to all this computer stuff, but LOVE your designs.
Please, can you help me find it.
Also, what Family of San Luis Valley Myers' do you belong to????
Thanks for the comments everyone! This has been one of our most popular designer interviews yet. Look out for some great free patterns from Meg coming up in our Web-Letter, sign up on the website!ReplyDelete
Hi Aileen,ReplyDelete
Thanks for the kind comment! The red lacy pattern isn't quite ready – your hunt was probably fine, but there was nothing to find yet! It is going to be a free Web-Letter pattern in April. The best way to make sure you don't miss it is to make sure you are a Web-Letter subscriber (sign up at the top of this page: http://www.classiceliteyarns.com/newsletter.php).
As far as the Myers' in the SLV, I'm part of the potato farming clan in the Center/Hooper area. You must a valley person yourself to know to ask the question!
My mother and I are interested in creating our own cottage industry of knitted items. Your Eyelet Swirl Hat is such a good pattern and we're asking for permission to knit and sell them. We would gladly add your name as the designer to our labels! What do you think? JennyReplyDelete


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Washington Collection
Lemon Squeezy
We believe that buying a new Kitchen or Bathroom need not be a complex nor expensive experience.
So from your visit to our showroom, right through to the completion of your project we aim to help you understand the whole concept, from product pricing up to installation. Read more..
Quick links
Director: P.Sherry Registered in England 05770706, Reg Office: 25a Aire Valley Business Centre Lawkholme Lane Keighley West Yorkshire BD21 3BB
All images shown are not owned by Lemon Squeezy Kitchens & Bathrooms ltd
© Lemon Squeezy Kitchens & Bathrooms Ltd 2016 All Rights Reserved - Yuuzuu


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For information about Redstone American Grill and its locations, Click Here.
Each gift card in the Redstone American Grill gift card program is redeemable only up to the available balance of the card. Therefore, it is important that each card owner track the balance of his or her gift card. To inquire about the balance of a gift card, a gift card owner should:
For more information about gift card balances, see Tips on Use.


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We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Kashgai Kilim - 2.1m x 1.52m
(Includes taxes)
A one-to-one personal service with our in-house design team, who are on hand to help find the best rug for your space.
- Home Approval Service
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Stock Id: A33481
Measurements: Length 2.1m x Width 1.52m
Trade and Contract
Sign up for exclusive trade benefits including access to our TRC LAB: Handtufted Collection for our trade partners


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Shirley Agudo Photography
As an American documentary or 'street' photographer and photojournalist living in the Netherlands, I specialize in capturing the drama on the streets of Europe, i.e. the behavior of people and their relationship with their surroundings. To date, my photography has been exhibited in Amsterdam, Berlin, Brussels, New York City and Tunis (Africa), and I am represented by Eduard Planting Fine Art Photographs (Amsterdam).
As founder of the Amsterdam Street Photographers' collective, I also conduct street photography workshops. In addition, I am the author/photographer of 6 books: The Dutch and Their Bikes, Bicycle Mania Holland, Fodor's Holland, Hot Pink,Here's Holland and Network Your Way to Success.
Most of my photos are available for purchase, including a music 'video' based on my book, Bicycle Mania Holland.
Contact: Shirley Agudo
Note: This website is being updated at the moment. Stay tuned.


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Lonny Balbi pedals by example.
Year-round, snow or shine, the eco-minded lawyer rides his mountain bike seven kilometres to his office in central Calgary, his suits and ties neatly folded in his backpack.
Balbi could no doubt afford some two-wheeled bling, but he's not into fancy, high-end rides. His purple Rocky Mountain Fusion doesn't even have shocks. Balbi gets a good dose of ribbing at the bike shop when he goes in for tune-ups.
"It's not a great bike, believe me," Balbi says. "There's nothing magic about it. Every time I take it in to get it fixed, they say, 'You know, Lonny, we do have new technology.' They always make fun of me."
Seven years ago, Balbi created Bike to Work Calgary in the hope of inspiring others to release their grip on steering wheels and latch onto handlebars for a day. "How can you go wrong when you're taking a car off the road, not polluting the air, you're getting exercise and doing something that's quite fun?" he says. "And in many cases you can get to work faster on your bicycle than in your car."
It may only be one day, but the theory is, if people try it and see how easy and enjoyable it is to commute by bike, they might get hooked.
"If we can get people to think about trying it once — if you realize this is fun and it kind works — you might do it more often, you might do it all summer," Balbi says.
Bike to Work Day, now endorsed by the City of Calgary, has grown from 700 participants in the first year to approximately 3,000 in 2012. It always happens in spring, in the hope participants will get the bike bug early in the season. This year, Calgary's Bike to Work Day happens the morning of May 3 and culminates with a free pancake breakfast at Eau Claire Market. The event includes all sorts of freebies and bike prizes.
Creating the awareness-raising event has landed Balbi on the list of finalists for a 2013 Emerald Award. He is one of four people shortlisted in the individual commitment category. The awards, administered by the Alberta Emerald Foundation, recognize outstanding commitment to environmental initiatives in this province.
"It sure is a nice thing to be recognized for a pure community event that I love doing," Balbi says. But winning the award isn't important. "I'm just doing it because it's my idea and I love it. I love the fact we can keep another car off the road."
Many people are nervous or skeptical about riding to work, he explains, especially in car-oriented cities like Calgary and Edmonton. What many don't realize, he says, is that Calgary is blessed with an intricate network of bike paths that make a bike commute enjoyable and safe.
Promoting an environmentally friendly, healthy and inexpensive alternative to car commuting with an annual "day" isn't cheap. Every year, Balbi puts about $20,000 of his own resources into making Bike to Work Day happen for Calgarians.
It's worth every dollar, every billable hour.
"I want it to be bigger and bigger and bigger," he says. "It's going to be a big social event, that's what I'm trying to do. I'm not happy even with 3,000 cyclists; I would want to see 50,000 cyclists, I would love to see that."


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Unfortunately nothing is free in this world.
We just trying to be fair with the customer and we letting them see Full picture of the product price until proceeding to checkout.
However Free is only our Standard delivery option which is available for major Canadian cities only between 9am and 7pm.
If you would like to specify the delivery time range then you will need to pay small additional fee.


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4-27-2013 USMS National 5K OW Champs Miromar Lakes
by, April 28th, 2013 at 08:36 PM (4261 Views)
It was a beautiful day, and the lake was just awesome to swim in. In the 2012 version of this 5K OW swim there were about 50 masters swimmers, and for the 2013 USMS National 5K OW Championhips the participation list was over 120. While not a large OW event compared to major metro areas, it was a very good interstate draw for this area. My family and I took a trip to see my uncle in the Keys afterwards, so I was not able to make the event report until now.
I placed 2nd in masters men 55-59 and 20/65 overall of masters men. While the head wind on the longest length of the course was a factor for all of us, I somehow just did not have the same kind of energetic swim I had last year, as my arms ached during the most of the first two laps. Several spectators said I made a strong effort on the third lap passing 8 swimmers in the last half of the final lap. One of my occasional training partners who is in the 40-44 age group that I tend to be slightly faster in LCM 100/200 repeats in our workouts together at FGCU, swam this 5K about 6-7 minutes faster.
(left-right) Jim Stewart was the winner, followed by myself, Wayne Hannum, Carlos Lloreda, R Walker
Honestly, I was slightly disappointed, but I am in participating in Masters Swimming for the long term and it is just one swim. It will all balance out by participating in more kinds of swimming events, enjoying what Masters Swimming has to offer in terms of training, friendships, and competitive opportunities. On reflection, there are some variables to consider that may have some minor significance between last year and this year's performance, but I am really not going to over analyze, rather just keep going forward from this point.
I really want to thank all you USMS forumites for such great encouragement and support, and who have helped me to become a better swimmer in the short time I have started training, blogging and participating in the USMS forums.


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Perfect at home, the Seattle Seahawks managed a win on the road for a change.
They needed overtime to do it, and the extra time spent might help them make the playoffs.
Russell Wilson connected with Sidney Rice for a 13-yard touchdown with 7:33 left in overtime to lift the Seahawks to a wild 23-17 victory over the Chicago Bears on Sunday.
Unbeaten in five home games, the Seahawks finally figured a way to win on the road after dropping five of their first six, and knocked off the NFC North leaders in the process.
Seattle (7-5) leads the NFC wild-card chase and, despite its frequent struggles on the road has won three in a row in the regular season at Soldier Field
This one sure was dramatic.
Seattle took a short-lived lead late in regulation on rookie Wilson's 14-yard pass to Golden Tate, only to watch the Bears' Robbie Gould boot a 46-yard field goal as time expired to send it into OT.
The Seahawks (7-5) started with the ball on their 20, and it ended with one final flourish.
Rice hauled in a pass from Wilson and took a shoulder-to-helmet hit from Major Wright that appeared to knock him out as he lunged into the end zone. He stayed down for several minutes but eventually walked off the field.
That gave the Seahawks their only road win other than a victory at Carolina.
They pulled it out even though Marshawn Lynch was held in check with 87 yards rushing. He had a touchdown in the second quarter, but also fumbled on the game's opening possession, leading to a score for Chicago.
Wilson threw for 293 yards and two touchdowns and was particularly cool down the stretch, sending Chicago (8-4) to its third loss in four games. Making matters worse for the Bears, the injuries mounted.
Linebacker Brian Urlacher (hamstring) and cornerback Tim Jennings (shoulder) were hurt on the winning drive. Receiver Earl Bennett (concussion) and safety Chris Conte (illness) left earlier in the game. The Bears had already ruled out return specialist Devin Hester (concussion) and guard Chris Spencer (knee) after they were injured against Minnesota. Throw in the torn ACL guard Lance Louis suffered against the Vikings, and the Bears were a short-handed bunch.
Even so, they had their chances.
Jay Cutler threw for 233 yards and two touchdowns. Brandon Marshall added 165 yards receiving, but the Bears came up short late in the game and in OT.
They were leading 14-10 when Adam Podlesh pinned Seattle on the 3 with 3:40 remaining. Wilson orchestrated a dramatic drive, capping it with a 14-yard pass to Tate that gave the Seahawks a 17-14 lead with 24 seconds left in regulation.
The Bears weren't finished, though.
Cutler hit a leaping Marshall with the Seahawks' Richard Sherman and Earl Thomas on him for a 56-yarder that put the ball on the Seattle 30. Gould then nailed a 46-yard field goal to send the game into overtime.
Read up on the recaps and analysis from our sports team in the live blog below.
[View the story "Chicago Bears vs. Seattle Seahawks" on Storify]


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ICMR and NIH are jointly proposing to conduct the Joint Indo-US Grantsmanship and peer review workshop under the aegis of the Indo-US Joint statement on 'Prevention of Sexually Transmitted Diseases and HIV/AIDS' on 6th-7th February, 2013 at India International Center, New Delhi.
The objective of the workshop is to provide opportunities for young investigators and postdoctoral fellows/trainees to develop grant-writing skills, network with leading HIV/AIDS researchers, and promote collaborations for HIV/AIDS research projects. The workshop will include presentations by ICMR and NIH Secretariat on the ICMR and NIH research programme, tips for writing a successful ICMR/NIH grant application, ICMR/NIH funding mechanisms, and potential sources of funding.
Experts in the field of HIV/AIDS prevention science from India and US as well as representatives from Indian/US funding agencies will participate. The workshop will also include experts in the various fields of HIV/AIDS research.
In the workshop it is proposed to have panel discussion and identify scientific priorities. The participants will be informed regarding essential elements to be included for writing grants for NIH/ICMR, common vision and areas of differences.
There will be a breakout session after the discussion of priority areas of both the countries. The breakout sessions for investigators will be mentored by eminent experts for development of the draft proposal. The involvement of investigators may provide opportunities for future collaborations that would allow national and international investigators to explore and collaborate with potential collaborators/consultants.
The scientists, who have an interest in collaborating with junior level investigators in India/US, are expected to participate in breakout sessions to explore possible collaborations and to develop joint draft proposal. The draft proposals would then be discussed after the presentations.
Deadline for submission of applications to participate in the Grantsmanship Workshop is 31st December 2012.
Kindly send the completed application form via email to
Dr. Manjula Singh at email@example.com or at firstname.lastname@example.com
Shortlisted candidates will be duly informed.
Read more on http://www.icmr.nic.in/icmrnews/workshop/indo_Us.htm


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05/22/16 Student Recognition Day @ History Park SJ
"Thank you so much for taking the time to speak to our class about the rich Chinese American history present here in San Jose. Many of the students did not know that these buildings were here, much less the history, and it was very eye-opening to learn."- Asian Pacific American Leadership Institute (APALI)


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SKF powering the wheels of Koenigseggs new Regera
2015 April 09, 14:00 CEST
Gothenburg, 09 April, 2015: SKF is supplying Koenigseggs with front and rear wheel hub bearing units equipping their new car model Regera, launched at the Geneva Autoshow early March.
Jean-Sylvain Migliore, Manager Racing, Automotive Market says, "Our development of components to fit the needs of motorsport and performance cars is really pushing SKF to the extremes. Designing the bearings to fit the ultimate driving experience with mega performance providing high customer satisfaction is a pure pleasure. We take great pride in our work and we are happy to be contributing to Koenigseggs power and responsiveness."
The Regera offers a combination of power, responsiveness and luxury. In spite of all its advanced technology and high comfort level, the Regera is comparatively light. This allows it to still perform competitively around a race circuit. However, on the highway, the Regera will reign as "King of the road", as the fastest accelerating, most powerful production car ever, according to Koenigsegg.
The Regera will be handcrafted in only 80 examples.
SKF has been a partner to Koenigsegg since its beginning, and also supplies the Agera RS and ONE:1 with wheel bearings.
Aktiebolaget SKF
For further information, please contact:
Press Relations: Monique Turner, +1 267 436 6836; +1 215 801 8722; firstname.lastname@example.com
SKF is a leading global supplier of bearings, seals, mechatronics, lubrication systems, and services which include technical support, maintenance and reliability services, engineering consulting and training. SKF is represented in more than 130 countries and has around 15,000 distributor locations worldwide.
Annual sales in 2014 were SEK 70 975 million and the number of employees was 48 593. www.skf.com
® SKF is a registered trademark of the SKF Group.
Pressimaterjalide allalaadimine
- Regera (1.4 MB) eelvaade