text:
To order our 2019-nCoV products with priority shipping, click here.
Research profile: Learn how scientists at Adaptive Biotechnologies developed a high-throughput method for sequencing and quantification of rearranged antigen receptors on T- and B-cells. They used gBlocks Gene Fragments to create a "gold standard synthetic immune system" where the binding sites for every possible forward and reverse primer combination for a given receptor type were represented.
The Seattle-based company, Adaptive Biotechnologies, grew out of research collaborations at the Fred Hutchinson Cancer Research Center. The core technology offered by Adaptive is a high-throughput method for sequencing and quantification of rearranged antigen receptors on T- and B-cells.
Coauthors Dr Anna Sherwood and Dr Ryan Emerson talked to us, along with Dr Mark Rieder, VP of Operations at Adaptive Biotechnologies, about their recently published paper, Using synthetic templates to design an unbiased multiplex PCR assay [1], and their advancements in massively parallel sequencing for profiling of the diversity of an individual's T-cell receptor (TCR) repertoire. This immunosequencing assay is a new approach to quantifying unknown T- and B-cell input templates and has many potential diagnostic applications, including tracking the presence of cancer cells in leukemia patients.
The diversity of T- and B-cell populations is vast and until recently it has not been possible to know the quantitative composition of the many receptor types in a given sample. For example, just for TCR-β receptors there are potentially trillions of possible rearrangements that can be produced from the germ-line receptor gene, meaning that the TCR-β gene acts as a unique sequence tag for each T cell. A single T-cell can be identified by the TCR that it displays, as well as any cells that came from the same parent cell. Cells displaying the same TCR due to common descent are known as clones, and they are central to the adaptive immune response. In total, at any one point in time profiling the antigen receptor of circulating T- and B-cells represents a sequencing space nearly 30x greater than the human genome (3 Gb).
Identifying a high-copy clonal population of cells that is expanded due to some pathological process is relatively easy to do by sequencing of a small sampling of T- or B-cells (e.g., in acute lymphocytic leukemia), and looking for an abnormally high proportion of cells sharing a single receptor sequence. The problem arises when investigators are interested in low-copy, or single-copy, clonal cell populations (e.g., in tracking the residual burden of a leukemic T cell clone after most of the cells have been killed off by therapy).
Until the development of next generation sequencing, only low-copy clonal populations that had been previously identified, and that could be amplified for sequence analysis, could be tracked. The resolution for other low level clones of potential interest, or the overall sequence representation of all the receptor types in a sample could not easily be determined.
The adaptive immune system is a very dynamic system that is time-varying and constantly responding to environmental interactions. Understanding in detail these dynamic changes in immune cell diversity, even for very low copy clones, will significantly increase our knowledge regarding the adaptive immune response.
In their publication [1], researchers at Adaptive Biotechnologies examine the makeup of T-cell receptor gamma (TCRG) V- and J-gene sequences, as a representative example of their approach. The first step in sequencing using the Illumina platform involves isolating the DNA of interest. The V- and J-gene combinations are isolated from samples using multiplex PCR to amplify rearranged receptor genes, using primers that recognize all of the possible combinations of these randomly mixed gene regions.
Using multiplex PCR to isolate TCRG sequences is a powerful method, but requires careful optimization in order to avoid changing the quantitative representation of the receptor genes in the pool, and to prevent low-level or under-amplifying sequences from being left out of the final data set.
When performing multiplex PCR, the primers need to have similar amplification efficiencies in order to make comparisons of data quantitative; this can only be done experimentally by conducting a multiplex PCR on a sample with known concentrations of input target sequences and quantitatively comparing the results to output values. Learn more about multiplex qPCR in the DECODED article, Multiplex qPCR—how to get started.
Adaptive has developed a very powerful tool, taking advantage of recent advances in synthetic biology which allow them to use multiplex PCR and sequencing to quantitatively look at the adaptive immune response with high accuracy and throughput. According to Dr Rieder, "if other companies do not have the same type of definitive standards, where they can identify their amplification bias and adjust for it, they cannot make the same claims about their assay being comprehensive and quantitative."
In order to use multiplex PCR to quantify TCRG receptors in clinical samples, Drs Sherwood and Emerson explained how they address the amplification bias of the multiplex primers. The key to quantifying the amplification bias of all of these potentially interacting primers is to have an input in which the exact quantitative composition of the pool is known. From there they can experimentally quantify the output from that pool, and see how it differs from the expected results. For most genes, obtaining a sample with known input quantity is trivial (each gene amplified in the multiplex PCR is generally present at the same copy number, two per genome). When considering multiplex PCR for rearranged immune receptor genes, however, finding a precisely-measured pool of input templates has proven elusive.
Depending on the receptor type in question, the authors designed amplification primers, and corresponding synthetic receptor sequences, using gBlocks® Gene Fragments. The gBlocks Gene Fragments allowed them to create a "gold standard synthetic immune system" where the binding sites for every possible forward and reverse primer combination for a given receptor type were represented. In order to represent the human TCRG locus with 14 V domains and 5 J domains, the authors used 56 gBlocks Gene Fragments—J1 and J2 domains were amplified with the same primer sequence [1]. Figure 1A illustrates the V and J sequence locations in the TCRG locus in the human genome [2].
The synthetic templates, shown in Figure 1, were designed with terminal, universal adaptors A and B, and therefore, would amplify with the same primers. The universal adaptors were important because they served as an anchor for adaptors needed to quantify each template using a simplex PCR approach. After the templates were pooled and amplified from the universal adaptors, a quantitative representation of each template was determined by Illumina NGS sequencing analysis.
Internal to the universal adaptor sequences were combinations of forward and reverse priming sites for the antigen receptor V- and J-gene combinations, recognized by the multiplex primers. Using the multiplex primers recognizing these sequences, the researchers could determine whether the primers over- or under-amplified any of the TCRG receptor sequences.
Figure 1. Design of synthetic TCRG templates. (A) Shows the organization of the human TCRG locus on chromosome 7, and the relative positions of the 14, V and 5, J motifs [2]. (B) gBlocks Gene Fragments are used to create synthetic templates for an artificial immune receptor pool. A template is created for every possible V- and J- gene combination that is found in T-cell receptor gamma (TCRG) sequences. Universal adaptor sequences (UA and UB) are included for quantification of the synthetic template pool. A unique barcode (BC) is also included in each template for each V-gene/J-gene pair to provide additional verification beyond the gene sequence, as well as to make it possible to sequence the artificial template alongside the experimental sample. IM1 and IM2 are artificial sequences that further identify the gBlocks Gene Fragments as artificial templates during sequence analysis [1].
Adaptive used this data to iteratively adjust every single primer in their mix. Even if a particular primer combination was only off of the average amplification efficiency by a small amount, it still would be adjusted. Dr Emerson explained, "Since we know what the exact right answer is, we can adjust that primer concentration in the mix to get it as close to the correct answer as possible. If a primer is severely outcompeted in the multiplex, then we redesign it. We included a large segment of the V- and J-gene segments in the synthetic templates so that we can adjust priming sites as necessary without changing the gBlocks Fragments."
After the final adjustments were made, one more round of quantification was performed with the same reagents and methods. At this point, remaining bias was reduced towards the mean using computational methods (Figure 2).
Figure 2. Example of multiplex primer optimization for human IGHV (hsIGHV) sequences. Similar to the published TCRG example, a synthetic pool of IGHV targets was created with gBlocks Gene Fragments. The data shows the experimentally-observed amplification bias for the multiplex primers, using the synthetic receptor sequences (black bars). Following this initial multiplex experiment, the amplification bias of each primer is determined as the difference from an average amplification efficiency, or normalized value of 1. The concentration or design of the multiplex primers is then adjusted and the experiment repeated (red bars). Finally, much of the residual bias is removed by computation methods (blue bars). The adjusted multiplex primer pool is then ready to quantify even low level clones in unknown, complex biological samples. Unpublished data (source: Adaptive Biotechnologies).
The remaining features of the template that were not gene or adaptor related were: unique barcodes for each primer-pair combination, and two short sequences labeled IM1 and IM2 that contained sequences that identified these as synthetic templates (Figure 1). These sequence features helped with quantification of the pool, and elimination of any contaminating sequences. Such sequence features could also be useful in experiments where investigators want to have inline, positive controls.
Adaptive Biotechnologies initially tried to make all of their synthetic templates themselves. They did this using overlapping primer and PCR assembly, but these templates lacked a lot of the features used in the gBlocks Gene Fragments templates described here. Following the initial prototyping, the researchers realized that they had spent a lot of time and resources, without achieving their desired result.
Adaptive Biotechnologies was an early adopter of gBlocks Gene Fragments, because they knew that gBlocks fragments would be a "game-changer" for their assays. gBlocks Gene Fragments allow them to benchmark their assays, and reduce amplification bias; and these successes have really set the Adaptive technology apart from its competition. Adaptive Biotechnologies knew they could make a better assay faster, and the sequence verification that IDT performs on gBlocks Gene Fragments meant that the Adaptive Biotechnologies scientists didn't have to worry about assembly errors.
After optimization, Adaptive Biotechnologies has a multiplex PCR and sequencing assay that is able to give a very accurate picture of the quantity of clonal lymphatic cells, in this case T-cells that are circulating in the bloodstream. In their paper [1], the authors focused specifically on leukemia samples. In leukemia, there is typically one malignant clone circulating in the blood from which all other cancer cells descend. Using their assay, the Adaptive Biotechnologies scientists can get an idea of the number of those clones before, during, and after treatment.
Rigorous multiplex optimization ensures that even low level clones do not drop out because of experimental error. The necessary amount of multiplex PCR and sequencing varies depending on where an individual is in the progression of their disease. Before treatment, only a minimal amount of material is required to detect a highly expanded clone or set of clones, in the initial sample where the expanded clone will often consist of >50% of the identified sequences.
Following treatment, these clones may be as infrequent as 1:100,000, and analyzing 500,000–1,000,000 blood cells would be required to detect them. Even a single malignant cell left circulating can be a source for a new pool of cancer cells. In their paper, the scientists at Adaptive Biotechnologies showed that they were able to detect and quantify clones against "a complex biological background," that were present at a level of only 1 T-cell per 100,000 total input cells [1]. This level of quantification opens up a whole new level of sensitivity when trying to monitor long-term minimum residual disease (MRD) of hematological cancers.
In addition to gBlocks Gene Fragments, Adaptive Biotechnologies uses several other IDT products. Adaptive purchases their custom oligos from IDT, and takes advantage of the available custom formulation and mixing services to get their primers delivered in a ready-to-use format, which saves them a lot of time. Overall, the researchers' experience with IDT has been positive, and their early use of gBlocks Gene Fragments has been beneficial to Adaptive Biotechnologies.
Adaptive Biotechnologies Corporation ("Adaptive" or the "Company") is a pioneer in immunosequencing diagnostics, with a focus in oncology. The Company leverages advances in next generation sequencing ("NGS") to profile T-Cell and B-Cell Receptors ("TCRs" and "BCRs"). This enables in-depth characterization of the immune system, which is the primary defense against cancer. By incorporating immunosequencing into clinical care, Adaptive can enhance the diagnosis, prognosis, and monitoring of cancer patients. Adaptive incubates and validates potential clinical products by offering fee-for-service access to its proprietary immune profiling sequencing technology under the brand name immunoSEQ™.
Dr Anna Sherwood started at Adaptive Biotechnologies in a postdoctoral position after her PhD studies. As Director of Research and Development, her primary duties at Adaptive include the design, implementation and optimization of new immune receptor sequencing assays.
Dr Ryan Emerson is a recent PhD graduate with a background in genomics and molecular evolution. He is Director of the Computational Biology department at Adaptive and oversees the analysis and interpretation of the high-throughput sequencing data generated by Adaptive assays.
Hans Packer, PhD, former Scientific Writer, IDT.
Published Jan 10, 2014
Revised/updated Nov 17, 2016
Review other DECODED Online newsletter articles on synthetic biology and cloning applications.
Sequence-verified, double-stranded DNA fragments to simplify cloning or genome editing.
Gene fragments from 200 to 3000 bp shipped plated, or in suspension and ready for use.
© 2020 Integrated DNA Technologies. All rights reserved. Trademarks contained herein are the property of Integrated DNA Technologies, Inc. or their respective owners. For specific trademark and licensing information, see www.idtdna.com/trademarks.


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This isn't a thread to bash the guy, for better or worse I think he's done a great job. Its just that for the last two expansions the game has been bleeding subs by the millions. Now I know that WoW is aging and people are just not that interested in it anymore but in the world of business all that matters is how much profit you can make for the company. So way I see it, those last two expansions are like poor performance reviews for GC. He seems to be out of touch with the game as of late. The stuff he said about hunter utility I found to be kind of ridiculous and the inclusion of Flex Raiding seems like a cop out for lack of catch-up content. I don't think they would or should flat out fire the guy but I do think its time for someone else to take the lead. Let GC work below this person advising them. I would argue the same thing about Chris Metzen. Seems the guy can't be reasoned with and everything he says goes, lore-wise.
EDIT: I never wrote that he has the sole responsibility of the game therefore sub losses are all his fault. Apparently I wasn't clear enough, what I am trying to say is that he has a leadership position therefore if the game performs badly he is partly to blame. Of course he isn't in charge of everything but the truth is that companies always look at who's in charge whenever they are losing money. Of course this can be applied to Tom Chilton or anybody else in Blizzard. Also he isn't infallible he's adapted a lot of poorly developed ideas into the game over the years which have eventually been either completely removed or broken other aspects of the game.

subset: commoncrawl


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There's nothing in this world quite so delicious as cheese. And while I knew there was all sorts of bacteria and fermentation involved in delivering me unto cheddar, I never imagined it would be quite so graphic.
Microbiologist Rachel Dutton has gotten up close and personal with the bacterial ecology of your favourite types, which look as wildly different as they taste. From left to right, you're looking at Jasper Hill Farm's Bayley Hazen Blue, Cabot's Cloth-bound Cheddar, and Cowgirl Creamery's Mt. Tam. I'm not saying that these slides have turned me off from dairy... but please keep your electron microscopes away from my Reeses Pieces. [Good, thanks Mark!]


text:
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Difference between revisions of "Kernel"
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[[Wikipedia:Kernel (computing)|Wikipedia]]:
:kernel is the of computeroperating it is and the data processing the . The kernel 's system.
There are various alternative kernels available for Arch Linux in addition to the mainline Linux kernel. This article lists some of the options available in the repositories with a brief description of each. There is also a description of patches that can be applied to the system's kernel. The article ends with an overview of custom kernel compilation with links to various methods.
There are various alternative kernels available for Arch Linux in addition to the mainline Linux kernel. This article lists some of the options available in the repositories with a brief description of each. There is also a description of patches that can be applied to the system's kernel. The article ends with an overview of custom kernel compilation with links to various methods.
Revision as of 16:29, 29 March 2016
According to Wikipedia:
- The kernel is a computer program that constitutes the central core of a computer's operating system. It has complete control over everything that occurs in the system. As such, it is the first program loaded on startup, and then manages the remainder of the startup, as well as input/output requests from software, translating them into data processing instructions for the central processing unit. It is also responsible for managing memory, and for managing and communicating with computing peripherals, like printers, speakers, etc. The kernel is a fundamental part of a modern computer's operating system.
There are various alternative kernels available for Arch Linux in addition to the mainline Linux kernel. This article lists some of the options available in the repositories with a brief description of each. There is also a description of patches that can be applied to the system's kernel. The article ends with an overview of custom kernel compilation with links to various methods.
- 1 Precompiled kernels
- 2 Patches and Patchsets
- 3 Compilation
- 4 See also
Precompiled kernels
Official packages
- linux
- The Linux kernel and modules from the [core] repository. Vanilla kernel with a few patches applied.
- linux-lts
- Long term support (LTS) Linux kernel and modules from the [core] repository.
- linux-grsec
- The Linux Kernel and modules with Grsecurity Patchset and PaX patches for increased security.
- linux-zen
- The ZEN Kernel is the result of a collaborative effort of kernel hackers to provide the best Linux kernel possible for every day systems.
AUR packages
- linux-aufs_friendlyAUR
- The aufs-compatible linux kernel and modules, useful when using docker.
- linux-apparmorAUR[broken link: archived in aur-mirror]
- Linux kernel with AppArmor capabilities enabled.
- linux-bfsAUR[broken link: archived in aur-mirror]
- Linux kernel and modules with the Brain Fuck Scheduler (BFS) - created by Con Kolivas for desktop computers with fewer than 4096 cores, with BFQ I/O scheduler as optional.
- linux-chromebookAUR[broken link: archived in aur-mirror]
- The Linux kernel with patches added to support chromebook hardware.
- linux-ckAUR
- Linux Kernel built with Con Kolivas' ck1 patchset.
- Additional options which can be toggled on/off in the PKGBUILD include: BFQ scheduler, nconfig, localmodconfig and use running kernel's config.
- These are patches designed to improve system responsiveness with specific emphasis on the desktop, but suitable to any workload. The ck patches include BFS.
- For further information and installation instructions, please read the linux-ck main article.
- linux-eee-ckAUR[broken link: archived in aur-mirror]
- The Linux Kernel and modules for the Asus Eee PC 701, built with Con Kolivas' ck1 patchset.
- linux-fbcondecorAUR
- The Linux Kernel and modules with fbcondecor support.
- linux-gitAUR
- Linux kernel and modules built using sources from Linus Torvalds' Git repository.
- linux-libreAUR, linux-libre-ltsAUR, linux-libre-grsecAUR, linux-libre-rtAUR, linux-libre-xenAUR
- The Linux Kernels without "binary blobs".
- linux-lqxAUR
- Liquorix is a distro kernel replacement built using a Debian-targeted configuration and the ZEN kernel sources. Designed for desktop, multimedia, and gaming workloads, it is often used as a Debian Linux performance replacement kernel. Damentz, the maintainer of the Liquorix patchset, is a developer for the ZEN patchset as well.
- linux-lts34AUR[broken link: archived in aur-mirror]
- The Linux 3.4 Long-Term Support Kernel and modules.
- linux-lts310AUR
- The Linux 3.10 Long-Term Support Kernel and modules.
- linux-lts312AUR
- The Linux 3.12 Long-Term Support Kernel and modules.
- linux-mainlineAUR
- The Mainline Linux Kernel and modules.
- linux-mptcpAUR
- The Linux Kernel and modules with Multipath TCP support.
- kernel-netbookAUR[broken link: archived in aur-mirror]
- Static kernel for netbooks with Intel Atom N270/N280/N450/N550 such as the Eee PC with the add-on of external firmware (broadcom-wlAUR) and patchset (BFS + TuxOnIce + BFQ optional) - Only Intel GPU
- linux-pfAUR
- Linux kernel and modules with the pf-kernel patch [-ck patchset (BFS included), TuxOnIce, BFQ] and aufs3.
- linux-tresorAUR/linux-lts-tresorAUR
- The current/LTS Linux Kernel and modules with integrated TRESOR
- linux-vfioAUR/linux-vfio-ltsAUR
- The Linux kernel and a few patches written by Alex Williamson (acs override and i915) to enable the ability to do PCI Passthrough with KVM on some machines.
Patches and Patchsets
There are lots of reasons to patch your kernel, the major ones are for performance or support for non-mainline features such as reiser4 file system support. Other reasons might include fun and to see how it is done and what the improvements are.
However, it is important to note that the best way to increase the speed of your system is to first tailor your kernel to your system, especially the architecture and processor type. For this reason using pre-packaged versions of custom kernels with generic architecture settings is not recommended or really worth it. A further benefit is that you can reduce the size of your kernel (and therefore build time) by not including support for things you do not have or use. For example, you might start with the stock kernel config when a new kernel version is released and remove support for things like bluetooth, video4linux, 1000Mbit ethernet, etc.; functionality you know you will not require for your specific machine. Although this page is not about customizing your kernel config, it is recommended as a first step--before moving on to using a patchset once you have grasped the fundamentals involved.
The config files for the Arch kernel packages can be used as a starting point. They are in the Arch package source files, for example [1] linked from linux. The config file of your currently running kernel may also be available in your file system at
/proc/config.gz if the
CONFIG_IKCONFIG_PROC kernel option is enabled.
How to install
The installation process of custom kernel packages relies on the Arch Build System (ABS). If you have not built any custom packages yet you may consult the following articles: Arch Build System and Creating packages.
If you have not actually patched or customized a kernel before it is not that hard and there are many PKGBUILDs on the forum for individual patchsets. However, you are advised to start from scratch with a bit of research on the benefits of each patchset, rather than just arbitrarily picking one. This way you will learn much more about what you are doing rather than just choosing a kernel at startup and then be left wondering what it actually does.
See #Compilation.
Major patchsets
First of all it is important to note that patchsets are developed by a variety of people. Some of these people are actually involved in the production of the linux kernel and others are hobbyists, which may reflect its level of reliability and stability.
It is also worth noting that some patchsets are built on the back of other patchsets (which may or may not be reflected in the title of the patch). Patchsets (and kernel updates) can be released very frequently and often it is not worth keeping up with ALL of them; so, do not go crazy, unless you make it your hobby!
You can search Google for more sets, but remember to use quotes (
"-nitro", for example); otherwise, Google will deliberately NOT show the results you want!
Linux-ck contains patches designed to improve system responsiveness with specific emphasis on the desktop, but suitable to any workload. The patches are created and maintained by Con Kolivas, his site is at http://users.on.net/~ckolivas/kernel/. Con maintains a full set but also provides the patches broken down so you can add only those you prefer.
The -ck patches can be found at http://ck.kolivas.org/patches/4.0/
This patchset is maintained by a small group of core developers, led by Ingo Molnar. This patch allows nearly all of the kernel to be preempted, with the exception of a few very small regions of code ("raw_spinlock critical regions"). This is done by replacing most kernel spinlocks with mutexes that support priority inheritance, as well as moving all interrupt and software interrupts to kernel threads.
It further incorporates high resolution timers - a patch set, which is independently maintained.
[as said from the Real-Time Linux Wiki]
patch at https://www.kernel.org/pub/linux/kernel/projects/rt/
BLD is best described as a O(1) CPU picking technique. Which is done by reordering CPU runqueues based on runqueue loads. In other words, it keeps the scheduler aware of the load changes, which helps scheduler to keep runqueues in an order. This technique does not depend on scheduler ticks. The two most simple things in this technique are: load tracking and runqueue ordering; these are relatively simpler operations. Load tracking will be done whenever a load change happens on the system and based on this load change runqueue will be ordered. So, if we have an ordered runqueue from lowest to highest, then picking the less (or even busiest) runqueue is easy. Scheduler can pick the lowest runqueue without calculation and comparison at the time of placing a task in a runqueue. And while trying to distribute load at sched_exec and sched_fork our best choice is to pick the lowest busiest runqueue of the system. And in this way, system remains balanced without doing any load balancing. At the time of try_to_wake_up picking the idlest runqueue is topmost priority but it has been done as per domain basis to utilize CPU cache properly and it's an area where more concentration is requires.
Google Code web page: https://code.google.com/p/bld/
Grsecurity is a security focused patchset. It adds numerous security related features such as Role-Based Access Control and utilizes features of the PaX project. It can be used on a desktop but a public server would receive the greatest benefit. Some applications are incompatible with the additional security measures implemented by this patchset. If this occurs, consider using a lower security level.
The -grsecurity patches can be found at https://grsecurity.net
The goal of Linux Tiny is to reduce its memory and disk footprint, as well as to add features to aid working on small systems. Target users are developers of embedded system and users of small or legacy machines such as 386s.
Patch releases against the mainstream Linux kernel have been discontinued. The developers chose to focus on a few patches and spend their time trying to get them merged into the mainline kernel.
linux-pfAUR is yet another Linux kernel fork which provides you with a handful of awesome features not merged into mainline. It is based on neither existing Linux fork nor patchset, although some unofficial ports may be used if required patches have not been released officially. The most prominent patches of linux-pf are TuxOnIce, the CK patchset (most notably BFS), AUFS3, LinuxIMQ, l7 filter and BFQ.
See linux-pf for more information.
Individual patches
These are patches which can be simply included in any build of a vanilla kernel or incorporated (probably with some major tweaking) into another patchset.
Arch Linux provides for several methods of kernel compilation.
Using the Arch Build System
Using the Arch Build System takes advantage of the high quality of the existing linux PKGBUILD and the benefits of package management. The PKGBUILD is structured so that you can stop the build after the source is downloaded and configure the kernel.
See Kernels/Arch Build System.
This involves manually downloading a source tarball, and compiling in your home directory as a normal user. Once configured, two installation methods are available; the traditional manual method, or with Makepkg + Pacman.
See Kernels/Compilation/Traditional.
See also
- O'Reilly - Linux Kernel in a Nutshell (free ebook)


text:
Last Updated: 2 days ago
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Actual schools may vary. Contact the builder for more information.


text:
This is promition of my online spelling dictionary.
Input = abstract easy symbols of American pronunciation.
Output = corresponding spelling.
URL is below.-- open new page( right click & new-open?).
Please check it out once, if you have a time.
(How to use is given in above LINK-page. "Try & Learn" on your real PC.)
--- perhaps, it may be interesting.
--- if so, I'm happy.
How does it work?


text:
The new NVIDIA Quadro P400 combines the latest Pascal GPU architecture with 2GB of ultra-fast on-board memory to deliver great performance for a range of professional applications. A single-slot, low-profile form factor makes it compatible with even the most space and power-constrained chassis. Support for three 4K displays (4096 x 2160 at 60Hz) with HDR color gives you a wide visual workspace to view your work in extremely high resolution.
Professionals are increasingly looking to lower the total cost of their computing solutions. Today's modern multi-application workflows require users to evaluate the impact of workstation functionality and performance against cost to ensure that any savings achieved by lower cost computing solutions will not result in schedule impacts and business loss.
With support for DisplayPort 1.4, the P400 can drive resolutions of up to 5K (5120 x 2880) at 60 Hz from a single cable. You can combine up to four Quadro GPUs in one system to simplify the deployment of display walls or other immersive display environments. DisplayPort 1.4 offers HDR color support, enabling brighter displays, more saturated colors and a greater than 10,000 to 1 contrast ratio.
Based on state-of-art 14nm FinFET process technology with 256 CUDA cores, the Quadro P400 provides performance and efficiency for CAD, DCC and visualization professionals in small and power efficient form factor.
2GB GDDR5 memory with up to 32 GB/s memory bandwidth delivers the performance boost and responsiveness demanded by entry level graphics applications.
Dynamically allocate GPU resources for graphics and compute tasks as needed to maximize resource utilization.
Deliver faster than realtime performance for transcoding, video editing, and other encoding applications with one dedicated H.264 and HEVC encode engines and a dedicated decode engine that are independent of 3D/compute pipeline.
Achieve higher application performance without exceeding the power and thermal envelope of the board. Pascal GPU technology maximizes the boost potential of the GPU.
Dramatically reduce visual aliasing artifacts or "jaggies" with up to 64X FSAA for unparalleled image quality and highly realistic scenes.
Texture from and render to 16K x 16K surfaces to support applications that demand the highest resolution and quality image processing.
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Support three 4K monitors at 60Hz, or one 5K at 60Hz, the P400 supports HDR color for 4K at 60Hz for 10/12b HEVC decode and up to 4K at 60Hz for 10b HEVC encode.
Built in compatibility with High Dynamic Range (HDR) TV's and Display devices (Windows only), whether it's a custom application or video, which will be accelerated by the on chip 4K at 60Hz 10bpp HEVC decode or up to 4K at 60Hz for 10bpp HEVC encode.
Gain unprecedented end-user control of the desktop experience for increased productivity in single large display or multi-display environments.
Provide a smooth and immersive 3D Stereo experience for professional applications.
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Maximize system uptime, seamlessly manage wide-scale deployments and remotely control graphics and display settings for efficient operations. Multi-GPU Technology.
Combine the visualization and interactive design capability of multiple GPUs by leveraging a mix of Quadro GPUs to dramatically improve the production workflow.
PNY provides unsurpassed service and commitment to its professional graphics customers offering: 3-year warranty, free pre- and post-sales support, dedicated Quadro Field Application engineers and direct tech support hot lines. In addition, PNY delivers a complete solution including the appropriate adapters, cables, brackets, software installation disc and documentation to ensure a quick and successful install.


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If you've got a little Erin in your go Bragh, you'll want to be able to show it off on March 17. And while the Irish Heraldry app has been around since December, 'tis finally the season to get your Irish up.
The app packs in 1200 Coats of Arms, full colour family crests, and a guide to what those symbols actually mean. Because you never know when you're going to need to back up that "Kiss me, I'm Irish" move. [iTunes]


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D-Backs; Alumni Comments
If the season ended today, the Diamondbacks and Phillies would meet in one of the NL Division Series, which is 47 days away.
With 19 wins since the All-Star Game break, the Diamondbacks have overtaken the Giants in the NL West. Last time they led this late in the season: 9/5/08.
Some Arizona facts:
**Lead the NL in extra base hits.
**Lead the NL with 33 comeback wins.
**Only NL team without a loss after 8 innings (65-0). Phillies are next, 65-1.
Phillies and Diamondbacks met toward the end of April in Phoenix. The D-Backs won 4-0 (Kennedy over Lee), 7-5 (Halladay's first loss) with the Phillies winning the finale, 8-4.
At Citizens Bank Park, the Phillies have a 15-7 edge, wining the last seven.
Comparing Numbers
Hitting: Phillies .252; AZ .250
Runs: AZ 556; Phils 528
ERA; Phils 3.09; SAZ 4.02
Runs allowed: Phils 391; AZ 529
Runs differential: Phils 137; AZ 27
Home record: Phils 42-19; AZ 334-16
Road record: Phils 36-22; AZ 32-27
Wednesday night's game will be on ESPN . . . On this date a year ago, Phillies were 66-51, second place, 2 games behind Atlanta. Braves play Giants now and D-Backs next.
Before Monday's midnight deadline, the Phillies signed the following draft picks from this summer: OF Larry Greene (pick 1A), SS Roman Quinn (2nd round), SS Mitch Walding (5th round), RHP Jesen Therrien (17th round), LHP Braden Shull (27th round), and OF Jonathan Knight (49th round). Phillies signed 30 of the 50 players they selected.
Taylor-Wise Puzzle
Appreciate all the comments from Monday's post. Will investigate the facts, something that I probably should have done in the first place. Hopefully, I will have some answers on Wednesday.
In response to one of the comments—why doesn't Bowa come to Alumni events? For years Larry was coaching and couldn't be here. He was planning on attending Friday's Wall of Fame induction but he works for the MLB Network and he was sent to an assignment in Chicago.
Congratulations Jim
Awesome that Jim Thome got to 600 home runs on Monday night, hitting a pair in Detroit. Only seven others have ever done that, which opens the question: is Jim a Hall of Famer?
Hard to believe it was eight years ago that we signed him. Time flies too quickly.
Of those 600, 96 came in a Phillies uniform, including #400 at Citizens Bank Park in 2004.
A class person is now in an elite class.


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Since our start as a blog called #PopHatesFags in 2012, PHF has consistently provided you with the latest pop culture news and hottest new releases. Join us as we analyse everything pop culture, build new friendships, and discuss the latest news and tracks exclusive to #PopHatesFlops!
Congratulations to coolaideonfire, our Member of the Month for the month of March! coolaideonfire is one of our longest running active members and has been with us for over five years, making almost 400 posts since they joined us in January of 2014. We've loved every second of having them around and we look forward to another five years together!


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I am a graduate of the National Midwifery Institute, which is a 3 year, Midwives Education Accreditation Counsel (MEAC) school, and also have taken trainings with Doulas of North America (DONA) and Birthing from Within. I'm certified with the North American Registry of Midwives (NARM) as a Certified Professional Midwife (CPM), and additionally I am Advanced Life Support in Obstetrics (ALSO)certified. I am current in CPR and Neonatal Resuscitation. And yes! I am a licensed midwife (LM) in the Commonwealth of Virginia.
I worked at the Doula Foundation of Mid America while going through midwifery school, which allowed me to support high risk women who had chosen the medical model with hospital-based care. I obtained my clinical training at a very high volume birth center, Casa de Nacimiento in El Paso, TX, as I wanted to gain as much hands-on experience as possible. I then moved to Springfield, Missouri where I apprenticed with an experienced and busy homebirth midwife. I have had the opportunity to train or work with 13 different midwives, and appreciate the depth that many perspectives and styles have brought to the care I provide for mothers and babies.
After completing my midwifery training in 2011 and becoming a CPM, I had a private homebirth practice in Southwest Missouri before I was offered a position as a staff midwife at Mamatoto Resource and Birth Centre in Port of Spain, Trinidad and Tobago. After careful consideration, I decided I wanted to be the woman who said yes, not no, to a grand adventure! I moved to the West Indies where I thoroughly enjoyed serving a diverse population and learning a whole new culture for 18 months. I have now assisted women from so many walks of life with their pregnancies and births… on the border of Mexico, I spent months serving Hispanic women who spoke no English; I've witnessed Amish women giving birth by lamplight; I've stayed with high-risk mothers birthing in the hospital; I've gently guided Rastafarian mamas to birth sweet island babies underwater; I've attended doctors' wives who chose home birth and placenta encapsulation and I've sat with hippie mothers singing to their unborn babies under the moon. The truth is all women birth in similar ways, and they all know how to do it. It's intuitive.
I am passionate about educating, supporting and empowering parents to find the path that is right for them and their baby. I believe strongly that all parents should have informed choice, not just informed consent. I believe my job as a midwife is to provide excellent, unbiased information and resources and trust that no one wants better for your baby than you!


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Death toll hits 15 in California mudslides; 24 missing
MONTECITO, California (AP):
Anxious family members awaited word on loved ones yesterday as rescue crews searched for two dozen people missing after mudslides in Southern California destroyed an estimated 100 houses, swept away cars and left at least 15 victims dead.
"It's just waiting and not knowing, and the more I haven't heard from them we have to find them," said Kelly Weimer, whose elderly parents' home was wrecked by the torrent of mud, trees and boulders that flowed down a fire-scarred mountain and slammed into this coastal town in Santa Barbara County early Tuesday.
The drenching storm that triggered the disaster had cleared out, giving way to sunny skies, as searchers worked carefully in a landscape strewn with hazards.
"We've gotten multiple reports of rescuers falling through manholes that were covered with mud, swimming pools that were covered up with mud," said Anthony Buzzerio, a Los Angeles County fire battalion chief. "The mud is acting like a candy shell on ice cream. It's crusty on top but soft underneath, so we're having to be very careful."
Fifteen people were confirmed dead and two dozen people remained missing, said Amber Anderson, a Santa Barbara County spokeswoman.
"We have no idea where they're at. We think somewhere in the debris field," she said.
Buzzerio led a team of 14 firefighters and six dogs in the debris field, which was spread over 30 square miles. They used long-handled tools to search the muck. By lunchtime, they hadn't found anybody, dead or alive.
Twenty people remained hospitalised, four in critical condition.
The deluge destroyed 100 houses and damaged 300 others, Santa Barbara County authorities said. Eight commercial properties were destroyed and 20 damaged.


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In their first season in St. John's after relocating from Manitoba, the re-named IceCaps finished first place in the AHL's Atlantic Division and made a deep run for the Calder Cup. With a largely similar core group of players still in the fold this year, there was reason to expect the team to build on its past success. More than half a season in, after a lopsided December and January, the IceCaps find themselves on the outside looking in. What exactly is going on in St. Johns?
The Offense
While last year's team put up significant numbers, at this point of the season Jason Jaffray holds the team lead with 23 points. His place at the top of the scoring column for the team means that not a single IceCap can be found within the top 100 scorers in the AHL.
Last season, the team's top scorer was big winger Spencer Machachek who posted 18-32-50 in 61 games and was named to the Western AHL All-Star team. He continued his good work in the post-season, notching 7 assists in 11 games. After consistently hitting in and around 50 points in several AHL seasons, Machachek had his best stint in the NHL last season going 2-7-9 in thirteen games with the Jets. It looked like Big Mac had turned the corner and was ready for the big time. This season, however, the wheels have fallen off. Now in his 5th AHL season, he's only put up 20 points through 43 games and is sporting a nasty -22.
Machacek and three others ended last year in the top 100 AHL scorers. With his poor showing this year and few others stepping in to carry the load in a big way, the IceCaps aren't scoring enough. Until they start to score more, they can't be expected to be Calder Cup candidates. Especially without stellar goaltending.
The Goaltending
Eddie Pasquale is an organizational project. Drafted by the Atlanta Thrashers in the 4th round his numbers have steadily improved season by season in the AHL. With him now putting up stats lines similar to his time in the OHL, he should be considered a success story.
What might be hurting the IceCaps the most is the lack of goaltending depth in the AHL. Last season, four goaltenders suited up for the IceCaps, with the bulk of the starts going to Pasquale or journeyman Swiss goalie, David Aebischer. Aebischer is a quality depth goaltender with experience in the NHL, Swiss League, and the AHL and though his numbers were far from stellar last season, the IceCaps did manage 15 wins with him in net.
This season, there is no Aebischer and Pasquale has been left to carry most of the weight on his own. Pasquale has already started 32 games halfway through the season, 6 short of his total played last season. He's just out of the top-20 goalies stats wise with a goals against of 2.48 and save percentage of .918 but he's currently carrying a losing record. Mark Dekanich is filling the backup role this season and has posted the worst numbers of his career. While neither of this goaltenders are terrible, they're not posting the numbers that you need when your team isn't scoring.
Ironically, Peter Mannino, who played 10 games with the IceCaps last year and is now with the Manchester Monarchs, has posted better numbers than both Pasquale and Dekanich through 20 games this season.
Defence is Offence
A large part of the IceCaps offence came from the D-corps last year. Of the top 5 scorers for the Caps last season, 2 were defensemen: Paul Postma, and Jason DeSantis, potting 44 and 43 points respectively.
This year, both Postma and DeSantis are gone, the former to the Jets and the latter having signed a one-year two-way contract with the Florida Panthers. Seeing as Postma was drafted by the organization in the 7th round back in 2007, that he is now in the third pairing on the Jets is good news, despite what it means for the IceCaps. Seemingly, management wasn't particularly concerned with losing DeSantis to free agency, perhaps because he did struggle at times in his own end last season. Though there were reasons for the loss of both, the IceCaps are struggling today without their impact in the offensive zone.
One thing is certain, you can never be sure a team's success in one season will carry over to the next. The wrong additions or subtractions can lead to different dynamics and sometimes players land in ruts. Unfortunately for the IceCaps, there seems to be a bit of everything going wrong.


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Date / TimeJune 2, 2020 until September 29, 2020
Location / MapCrossroads Bellevue Farmers Market
Northeast corner of NE 8th St. & 156th Ave.
Bellevue, Washington 98004
Event Description
We'd love to see you at the Crossroads Farmers Market, every Tuesday from 12:00 pm – 6:00pm. Enjoy fresh Washington produce, flowers, food, and fun. Live music fills the air and a local nonprofit community organization is featured each market day. There are contests, recipes and more all season long.
Look for our distributor's booth. We'll be sampling our delicious barrel aged balsamics and oils. Ask for Caroline Van Staden. She can be reached at 425.433.6047 or firstname.lastname@example.com.
Learn more about this market.
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It's time for another installment of "Getting Lost," where John S takes you through all the salient questions from last night's episode of Lost:
So, do you think Jack "has what it takes"? Well, I've never been one of the many Lost fans who hates Jack. For the first two or three seasons, he was my favorite character on the show, since he often struck me as the only person on the Island who was rational, prudent, and not totally self-involved. Granted, he's given to frustrating fits of stubbornness, like when he shattered Jacob's mirror in last night's episode, as opposed to waiting patiently to see what exactly the mission he and Hurley had been sent on was all about. But more often, Jack has done what it takes to keep survivors alive. It was Jack, after all, who coined "Live Together, Die Alone," and it was Jack who found the drinking water, and it was Jack who saved Charlie, and it was Jack who helped spring Sawyer and Kate from the Others, etc. He fails just as often as he succeeds, and his failings are more memorable—like in his unyielding but doomed efforts to save Boone in Season One—but he always goes down swinging. This is what makes Jack both tragic and noble. Continue reading


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Rick Alden Griffin Biography
Like so many comic artists, Rick Griffin showed his talent as a youngster. He attended the Los Angeles Chouinard Art Institute where an instructor told him: "You cannot make art with a Rapidograph!" His singular drawing style developed - still using the Rapidograph - with practical experience on publications such as Surfer Magazine, Car Toon Magazine, Hot Rod Cartoons and artwork for 'Big Daddy' Roth.
Settling in San Francisco in 1966, Rick Griffin's style reached maturity in the richly colored psychedelic dance posters he designed for Bill Graham's Fillmore and Chet Helm's Family Dog rock concerts. The famous 'Flying Eyeball' poster (Bill Graham #105) ranks as the most treasured of all his posters collected by fans and modern art museums alike. Rick drew comics for 'Zap', 'Snatch', 'Tales from the Tube' and the unforgettable designs for several Grateful Dead album covers. In August 1991, Rick was killed when a van he was passing while riding his motorcycle made a sudden left turn, driving him and his bike to the pavement.
Rick continued as official Surfer staff cartoonist until 1964 when his creative well began to suck sand. He took a leave of absence to clear his head. He was hitchhiking north to San Francisco to catch a freighter to Australia when the car he was in crashed outside of King City, flipped, dislocating an eye and nearly killing Griffin. The accident left facial scars that profoundly altered Rick's classic surfer good looks, his perception of himself, and finally, his art. After his recovery Rick grew a beard, wore an eyepatch and began to cultivate a darker, svengali-like look. Things changed.
On his return to Surfer, Murphy was indefinitely furloughed while Griffin himself, in cartoon persona, took centerstage with the escapades of the Griffin-Stoner adventures. In these preposterous surfaris, written by then-editor Pat McNulty, Rick Griffin and legendary surf-photographer Ron Stoner traveled the globe looking for waves, but invariably got sidetracked into outrageous capers at the local fleshpots. Invariably, the duo left behind a long trail of incensed authorities, ruinous expenses and wistful local girls.
But Rick's art had changed radically too. It became more sophisticated and worldly—dense, ornate imagery surrounded by loads of filigree and flowery mandalas. The lettering also took off in unexpected trajectories compressing, expanding, distorting and growing so intricate as to be almost illegible at times. And the new strips made sly references to Rick's newfound San Francisco influences The ZigZag man, hookahs, hippies, be-ins, music, bands, drugs a move that displeased many of Surfer's conservative advertisers. Over the course of a year the face of surfing began a subtle change from the clean-cut Jantzen boys into shaggy underground wave mystics.
Around this time he also began to play music with a proto-art band called the Jook Savages, a group of artists-musicians Rick had met in 1964 while attending Chouinard Art Institute (now Cal Arts). They made a trip to San Francisco to play in 1966 at the Psychedelic Shop, and although the band disbanded soonafter, the poster announcing their arrival was cosmic enough to attract attention to Rick. The next summer he was commissioned to produce a poster for a landmark non-event: the 1967 Human Be-In in Golden Gate Park. Rick's poster heralded the burgeoning counterculture that would soon engulf the world.
The tribes of surfing and the heads meshed easily from the start. The counterculture readily embraced surfers because surfing at its core is an earth ritual with an outlaw soul. Surfers didn't have to validate themselves to the enlightened they were already accepted by their nomadic outsider status.
"Rick, like the rest of us, was on a mission to turn on the world," says Jerry Garcia. "It was like, 'if you like that, you're gonna love this!' I dug Rick's stuff because it related so well to my own psychedelic experiences. Everything he ever submitted after to us always nailed it boom! like it grew out of the center of the earth."
After the success of the Be-In poster he did a series of now-classic concert posters commissioned by rock promoters Chet Helms of the Family Dog and Bill Graham of Fillmore fame. It was here that his fascination with heraldry the use of strong central images evoking war, regeneration and warning came into full bloom. His art went ballistic as mind-blowing renditions of skulls, eyeballs, Hopi masks, wings, snakes, beetles, embryos, wombs, flames and waves exploded across the canvas. Rick, along with other San Francisco "head artists"Alton Kelly, Stanley Mouse, Victor Moscoso and Wes Wilson were collectively known as "The Big Five" of psychedelia.


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Callahan lecturers say entitlement reform a must
Panel examines crises in Social security and Medicare funding
A panel of social policy experts at the first James Callahan Jr. Memorial Lecture said it is imperative that the United States reform the finances of its crisis-ridden entitlement programs.
Panelists were Stuart Altman, PhD, Sol C. Chaikin Professor of National Health Policy; Lisa Lynch, PhD, dean and Maurice B. Hexter Professor of Social and Economic Policy at the Heller School for Social Policy and Management; Lawrence Kotlikoff, PhD, professor of economics at Boston University, and Robert G. Romasco '69, president of the AARP, formerly the American Association of Retired Persons.
Lynch defined the crisis in Social Security, where growth in recipients without commensurate revenue growth leaves a fiscal gap that will deplete the trust fund by 2035. She also addressed the crisis in social security disability, where new applications have risen substantially in the recession, noting the program's disincentives to beneficiaries to reach their employment potential.
Altman criticized the political system for a failure to solve the even larger crisis in Medicare, noting that the government and private health care sectors are inextricably intertwined. He said the problem can be solved only through increased revenue and that cuts to provider payments will cause them to opt out of the system or leave beneficiaries with significant uncovered expenses.
Robert Romasco provided an overview of the AARP's mission of helping people live out their lives with dignity and purpose in an increasingly long-lived society. Medicare, he noted, covers only about two-thirds of costs for American retirees in a medical system that fails to deliver outcomes commensurate with costs. His organization has been engaged in broad discussions of policy options with stakeholders, including systematic reforms.
Kotlikoff characterized U.S. entitlement programs as "systematic fiscal child abuse," which places the burden of entitlements on future generations. Comparing the structure to a Ponzi scheme, he argued for a generationally fair policy solution including a clean-slate, individualized healthcare voucher program capped at ten percent of gross domestic product (GDP), freezing social security in its current form and adding a mandatory age-weighted investment and annuity program.
The newly-established lecture is supported by funds donated to the Heller School in Professor Callahan's memory. Callahan was a beloved mentor and friend who was acting dean of the Heller School 1990-92). He was the Commissioner of Mental Health for the Commonwealth of Massachusetts from 1983 to 1985, and Secretary of Elder Affairs from 1977-1979.
Categories: Humanities and Social Sciences


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Weekly Fraser Valley Sport fishing column; March 31 to April 7, 2014
I have an axiom, I coined when I started teaching
Fly Fishingclasses. Some of us are fortunate and learn the first around, but for the rest of us it takes a while.
I have long known about the great fishing in the State of Idaho and in recent years have been exploring the waters of Washington. My interest in fishing the Evergreen State was sparked when Kim suggested I read the book, Fly-Fishing Pioneers & Legends of the Northwest. My knowledge of our BC
Fly Fishingpatriarchs and their exploits is first class, thanks to the writings of Art Lingren; but to the waters below the 49th parallel, Im a novice.
On our first fishing trip south, I got to talking with a river guide, Dave Button; we met at Eatery Restaurant, (home of Tootsie world famous cinnamon rolls) of the Clarks Skagit River Resort. Dave wanted to pick my brain on our central interior rivers, while I pumped him for information on his stomping grounds. After a short period of time I laughed and said, Sounds to me like you boys let us BCers do all the bragging, while you guys keep your world class fisheries all to your selves.
Dave looked at me silently for a few moments and followed with, you know too much already. Our conversation was over and he walked away.
My second such experience was in the Bavarian town of Leavenworth. We walked into the town fly shop, to buy our fishing licenses and get some help in deciding where we would go fishing. Again I got to talking too much. In my spilling the beans about what I learned through my research I walked into another wall of silence. Little did I know that the Wenatchee River that runs beside the town is one of Washingtons premier steelhead streams.
Now what was that I said about getting it the first time around! Oh ya; kindly move to the back of the bus please, Jeff.
We will finish our story next week with; The Methow, Rufus Woods, and fry pan trout.
The Report
Our lower mainland lakes are fishing fair to good. For better success try working the north east sections of your favorite lake, from late morning through the afternoon. For wet (sinking)
Fly Fishingtry: Chironomid, Bloodworm, Pumpkinhead, Wooly Bugger, Big Black, Micro Leach, Zulu, Baggy Shrimp, Dragonfly Nymph, or Halfback Nymph. For dry (floating) fly action try: Lady McConnel, Griffith Gnat, Black Gnat, Renegade, Elk hair Caddis, Tom Thumb, or Irresistible.
The Fraser River back waters and sloughs are fishing well for cutthroat, rainbow, and Dolly Varden. For Cutthroat try: Alevin, Professor, Anderson Stone, American Coachman, Rolled Muddler, or Tied Down Minnow. For dolly varden try: Zonker, Flat Black, Big Black, Clouser's Deep Minnow, or Lefty's Deceiver.
The Vedder River is fair to good for rainbow, and steelhead. For rainbow try: Czech nymph, Kaufmann Stone, Hares Ear, Big Black, Zulu, Soubou, or Irresistible. For steelhead try: Steelhead Nightmare, Flat Black, GP, Kaufman Stone, Steelhead Spratley, Irresistible, or Stimulator.
The Harrison River is fair for cutthroat and rainbow.
Dont forget to renew your fishing license this week.
Keep your fly in the water
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|Some are incredibly delicate
I have over 200 memorial cards in that photo album. A treasure. I know that they were collected for a reason. Family members? Friends? Parishioners? Historical events? Most likely they are all of the above and I just need to figure out which ones are connected with my family. Regardless of which category they fall into, I'll eventually get each one posted.
There was some damage done by the magnetic album, but it didn't destroy any of the cards. It did ruin some of the beautiful artwork on the cards though. I love looking at the religious artwork on the cards. I love seeing the cards written in German and trying to see how much I can make out in that old script. And I love the cards with pictures of the departed on them.
|Damage done by the "glue" on magnetic photo albums
Is it odd to like memorial cards? Perhaps no more than roaming cemeteries and courthouses. We genealogists are an odd bunch!
Enjoy tending those roots!
|Gorgeous artwork. Who was he and why did he die in a military camp during WWI? The Great Flu?
|Gorgeous artwork


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Program Mission
The mission of the Honors Program is to bring Bethany's best students together in an interdisciplinary class setting where they can push themselves and one another in an academic community of equally prepared, motivated, focused, curious learners.
Program description & guidelines
Why You Should Apply
You will sharpen your critical thinking skills and be a member of an active and stimulating community. You will be challenged to perform your very best. You will be invited to engage with important ideas in a world that needs you.
Additionally, members of the Honors Program will enjoy the following privileges:
An annual Honors scholarship of at least $1000, subject to merit increases as the annual budget allows.
Funds available on a competitive basis to subsidize participation in academic conferences.
Priority in enrollment – you'll register for courses before all other students.
An overload fee waiver during the semesters you are taking Honors courses.
Faculty-length borrowing privileges at the library (that is, longer lending time).
Your Honors status will be included on your diploma. This communicates your customized, challenging coursework to future employers, graduate programs, and professional schools. Your Honors coursework will also mean you'll work closely with faculty across the disciplines – faculty who will not only help you explore diverse, integrated professional options but also direct you to unusual academic and research opportunities and provide you with crucial support and recommendations in the graduate school and job application process.
Application Criteria & Program Courses
See the Academic Catalog for application criteria and program courses.
Chair of Department of English Chair of Honors Program Associate Professor of English
Presser Hall 9
Department of English
(785) 227-3380, ext. 8129


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Brian Archibald necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 185 diseños de 59 diseñadores freelance.
Provida Life Sciences
We are committed to being the leading provider of products and services that offer practical solutions for improving health, longevity and quality of life. That is, we seek to transform lives. Our tagline is: Practical Solutions For Better Living. Our products primarily focus on educating our consumer in the areas we specialize. We sell educational products as well as nutritional supplements. But all of our products are backed by leading industry experts. For example, in our weight loss category, we utilize decades of nutrition and fitness science. We use medical science to ensure the efficiacy of all of our products whether they be in weight loss or other health enhancing categories such as sleep management. All of products are geared towards creating life change and results rather than silver bullets or miracle elixirs.
Thus, we have science behind everything we do, but the solutions are practical.
We advertise through television (DRTV) and through the web, but wish to have a corporate identity that demonstrates strength and scientific integrity but the compassion we have in seeking practical solutions to those in need of improving their health and well-being.
The target market is females and males, primarly 35-59 who seek to improve their health (perhaps they have a weight issue) or overall well-being (taking control of their life).
Our goal is to have a corporate logo associated with Provida Life Sciences that we can associate with each of the brands that we sell. For example, we sell Six-Week Body Makeover. Currently, we brand it as that. We would like to start to advertise that our products are "brought to you by Provida Life Sciences." Thus, our corporate logo should reflect all of our brands (as reflected in our mission) and be able to work well in television media as well as print, web, etc. We would also use this logo on all of our products. We wish to have the corporate logo be the "substance" and the "compassion" behind all of the brands that we sell.
We wish to have people use their creative energies to create something that is unique, but symbolic of the imagry we wish to convey. It cannot speak specifically to weight-loss, although that is our primary product category as of know. It should speak to other types of well-being aids.
Our different brands have their own style guides and there is no pre-determined style guide for this logo, but should be able to work in the aforementioned contexts. We would also this logo on our corporate website and for attracting quality employees and potential future investors.
Note: Provida (or ProVida) is pronounced "proveeda." It means "for life."
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Faded grey stripe & tabasco heart organic cotton baby blanket.
This product is currently sold out.
The Blanket
Organic cotton baby blanket, faded grey stripe on one side and a tabasco heart print on the other. Light and breathable with no nasty chemicals used on the fabric or in the dyes, perfect for your baby's delicate skin. Use to wrap, cuddle and nuzzle baby, also great for tummy time and playtime.
Our best selling blanket, featured in Baby London magazine and My Baba's 'On the Sofa Product Reviews'.
What's inside? (The brains behind the blanket)
The blankets are filled with our clever 3 layers of organic, unbleached herringbone weave muslin, nothing synthetic, reducing the risk of overheating. This unique filler design also means that the blankets will always retain their structure and stay light, snuggly soft and breathable. (Find out more about our muslin here.)
80 x 100cm / 32" x 40" (give or take the tiniest bit to allow for the movement of the natural muslin filler).
The Box
Wrapped in tissue and delivered in our beautiful signature keepsake box to remind you of those precious early times. When the day comes, the blanket can be neatly stored in it's box until the time it can be handed down to future babies and their babies too.
Laundry love
Our Laundry Love sachets are sold out and we're having trouble re-stocking. In the meantime this has been reflected in the price.
Inside the box you'll find some very special non-toxic, allergen free baby laundry sachets for the first wash. The blanket will come out cloudy soft and a little wrinkly just like your baby. It will get softer each time, can be tumbled or line dried and can be washed as often as you like.
Wash at 30 degrees, tumble or line dry, no need to iron (it's designed to be cloudy soft and a little wrinkly, just like your baby). It will get softer each time you wash it and can be washed as often as you like.GOTS and OEKO Tex 100 Class 1 certified organic cotton and muslin, so that means no nasty chemical residues for your baby's skin to absorb. It also means you've helped the people who grew and worked with the cotton as they were not exposed to any harmful chemicals either.
Azo-free dyes were used for the prints which is not only good for your baby but also for our rivers and oceans.
The box is made from recycled stock with a FSC liner and it is covered with acid free, Ecf and heavy metal free paper.
Always follow current official guidelines about infant sleep safety.
Giving back is a key part of what drives us.
As a company we are passionate about child protection and ending the exploitation of all children. When you buy a blanket, 5% of every sale goes to charities and projects that focus on protecting women, children and tackling exploitation. Follow us on our blog and Instagram to see who we are currently supporting. We are working towards a one-for-one business model and we'll keep you updated as we evolve. Thank you so much for your support.


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Mark Byrnes
Mark Byrnes is a former senior associate editor at CityLab who writes about design and architecture.
London introduced its new architectural symbol today, a 115-meter (377-foot) observation tower known as the ArcelorMittal Orbit, or "Orbit" for short.
Like many of its predecessors around the world, its aim is to serve as a symbol of civic pride for the city and for the urban regeneration of its neighborhood.
The era of observation towers as civic symbols probably started in Paris during the 1889 World's Fair. The brand new Eiffel Tower, equipped with a state-of-the-art elevator, was able to quickly and safely move visitors up to the top and back down. Originally planned to stand for 20 years, its popularity allowed it to become a permanent fixture and Paris' most famous architectural symbol.
Influenced by the Eiffel Tower, Russian artist Vladimir Tatlin proposed a constructivist-styled communications tower, titled The Monument to the Third International, in 1917. In true revolutionary fashion, it was planned to issue manifestos and news via loudspeaker and radio. It would also have, had it ever been completed, a projector capable of penetrating messages through overcast skies.
But despite its similarities to the Eiffel Tower, Tatlin's Tower had no plans for an observation deck. The completion of London's "Orbit" can be seen as a tourist-friendly, 21st century interpretation of its French and Russian predecessors. Unlike Tatlin's concept, its primary use will be as an observation deck and unlike the Eiffel Tower, it will not serve a dual purpose as a communications tower. Created by sculptor Anish Kapoor and designer Cecil Balmond, it will be Europe's tallest piece of public art.
Observation towers of the mid 20th century were less focused on the wonders of sculptural steel and instead were best identified by more rational-looking structural bases, a cylindrical form toward the top, and finished off with a spire.
Seattle's 1961 completion of the Space Needle served as an inspiration to its neighbors 100 miles north; a Canadian observation tower boom ensued for the following 15 years. Vancouver, Calgary, Niagara Falls, and Toronto all built similar styled towers up through the late 1970s (Montreal built one in 1976, but in keeping with Quebec separatist tradition, it bares little resemblance to its Canadian counterparts).
Canada's fixation peaked with the 1976 debut of Toronto's CN Tower, at the time the world's largest free-standing structure. Local intellectual circles saw it as a symbol of Toronto's inferiority complex, a rapidly changing city eager to prove its new worth. That theory was eloquently framed by Canadian pianist Glenn Gould, shortly after the tower's opening, in a video he narrated for the CBC.
Subconscious statements of inferiority aside, some cities just find their towers ugly. Prague's was largely seen as an outdated, communist-style attempt at futurism. The city's solution was to temporarily add bronze sculptures of crawling babies throughout. The babies were so well-received that they're now a permanent fixture.
Besides London's "Orbit," the sculptural steel aesthetic for these types of towers has returned. The Canton Tower in Guangzhou, completed three years ago, gives the appearance of a steel-constructed Chinese finger trap. Surpassing the Canton Tower in height, Tokyo will be introducing "Skytree" later this month. In what appears to be a mix of all its predecessors, it has the basic principles of the mid century observation tower while adding a sculptural steel curtain around its base.
Below, a sampling of some of the world's most unique observation towers:
Top image: The ArcelorMittal Orbit next to London's Olympic Stadium. REUTERS/Ki Price
Some renters and homeowners are getting financial assistance during the economic disruption from the coronavirus pandemic. What about landlords?
To help flatten the curve in the Covid-19 outbreak, officials at all levels of government are asking people to stay home. Here's what's worked, and what hasn't.
The latest U.S. coronavirus aid package promises a partial and uneven economic recovery that leaves behind the African American community.
Former HUD secretary and presidential candidate Julián Castro has ideas for state and federal leaders on protecting vulnerable renters from a housing disaster.
Will COVID-19 change how cities are designed? Michele Acuto of the Connected Cities Lab talks about density, urbanization and pandemic preparation.


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The Avocado Sisters are at it again! Rachael of La Fujimama and I got together for another avocado adventure yesterday. It was completely unplanned, but we had an excellent time! It began with a few tweets on Twitter. Rachael and … Continue reading
March 30, 2012
by Mimi Holtz
3 Comments


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Nicki Minaj Fights AIDS and HIV — In Barbie Form [PHOTO]
Attention Nicki Minaj fans — your idol has now been recreated in the form of a one-of-a-kind Barbie. You can even take her home, too… for the right price, of course.
Mattel's likeness of the quirky rapper, singer and songwriter — depicted as she's shown on her 'Pink Friday' album cover — is currently being auctioned off on CharityBuzz.com, with all proceeds benefiting Project Angel Food, a nonprofit that provides food for people with HIV and AIDS.
"For me, this is a very major moment," she told Billboard. "It just shows that you can come from nothing and still be a force in the main world, a business woman, and hopefully a mogul one day."


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Klaus Nomi would have been 69 today
Klaus Nomi's work isn't an acquired taste. You hear it and you either love it or you don't. I do. Nomi was a German countertenor with an astonishingly wide vocal range and an out-of-this-world persona. In one of my favorite music docs, The Nomi Song, he is described as the love child of Tristan Tzara and Maria Callas. That's pretty spot-on. Nomi died of AIDS-related complications in 1983. Check out Klaus Nomi A/V below.


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At Greenwich breakfast, talk of playing defense against the IRS
At the Delamar Greenwich Harbor hotel on Thursday, the breakfast buffet was a spread of fresh pastries, bagels, coffee and orange juice.
But the biggest thing to digest was the tale of Bob and Linda, a highly wealthy -- and hypothetical -- couple facing a world of trouble.
"It's a Saturday, and you're getting a call at every possible point of location -- your cell, your home, your office," tax attorney Seth Cohen was telling the crowd of about 30 accountants. "Every communication has essentially said: `I need to get in and speak to you. I need to get in on Monday.' "
Come Monday, Bob is a total wreck. "He's sweating, he's literally shaking in his boots," Cohen said. "He tells you that he got an exam notice. And he starts off by saying, `Don't tell Linda, but ...' "
`Eggshell' examination
How should you, the accountant, react?
That question was the point of Thursday morning's panel, one of a series of breakfasts covering legal issues put on by international law firm Withers Bergman, which has a Greenwich office at 660 Steamboat Road.
The topic Thursday was "eggshell" tax examinations, which were described as a civil audit of a taxpayer who in previous years has filed one or more false returns. At some point, as the Internal Revenue Service probes, Bob's accountant might discover signs of potential civil fraud or criminal violations.
"What we're trying to avoid is, quite frankly, a criminal tax violation, or a criminal referral to the criminal investigation division of the IRS during a civil examination," David Moise, another Withers Bergman partner on the panel, explained.
The panel consisted of four Withers Bergman attorneys -- three seated before the crowd and a fourth, Maurice Martin, visible a flat-screen TV as he participated by video from his office in London.
Bob, as the plot thickened, had also received a British exam notice concerning an entity of his across the Atlantic.
For Bob's accountant here, the first thing to do is to instruct him to stop talking and get an attorney, the panel said. That invokes the attorney-client privilege, which sets the stage for his defense.
From there, one option is to employ a "Kovel agreement," in which Bob's attorney hires an accountant who gets "cloaked" with the attorney's privilege to help with the case, Cohen explained. Because the agreement can not be retroactive, it helps to introduce a new accountant here.
Meanwhile, Bob's attorney should conduct an investigation of his or her own, reconstructing old returns properly as best as possible. That can help the defense answer questions the IRS is likely to pose.
The defense also needs to decide who will chiefly interact with the IRS. Skilled tax lawyers, for example, can probably sense from IRS agents' posturing and questions where the case might be headed.
"The game is to keep this civil," Cohen repeated. "Our clients are not incredibly pleased with having to pay a civil remedy. But they would be much more less-pleased to go to jail."
Knock, knock
Should the case turn criminal, Bob's accountant will likely get another phone call. Bob will have been visited at his front door by two IRS agents, either early in the morning or sometime around dinner.
"They generally have guns. They have shields," Cohen said, his tone leaving no question about his distaste for the practice.
"We do things very differently over here," Martin piped in from London. "We don't use guns, and we don't use shields."
In Britain, at this point, the government will simply write a letter inviting the taxpayer and his or her attorney in for an interview. "It's a very civilized procedure," Martin said.
Cohen spoke up again.
"I just wanted to say," he said, "that we hope to evolve to a point where we are equally as civilized as you folks are."
email@example.com; twitter.com/timloh


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Harry Mussatto Golf Course
The first course at Western Illinois State Teachers College was built on the lawn of Sherman Hall. It consisted of three rather short holes.
During the 1940s, the Western Illinois Teacher College expanded, and a 56-acre tract of land was purchased for the development of a new 9-hole golf course. The course was built on the northwest edge of campus. This course, commonly referred to as "Doc. Beu's Course," served the college for more then two decades. The need for land to further develop and expand the campus of Western Illinois University in the late 1960's created a necessity to move the course once again.
In 1970, the current 9-hole course was designed and constructed on University farmland just north of the Lamoine River. The course officially opened in 1972, and in 1973, the course was named in honor of Oscar L. Champion who coached the golf team from 1934-1943.
The Harry Mussatto Golf Course at Western Illinois University has been serving the campus community and the city of Macomb for over 25 years. It stands as one of the finest 18-hole golf facilities in the state of Illinois. The golf course was designed by Ken Killian and Dick Nugent, two of the finest golf course designers in the business. The facility features teaching stations which include a driving range, putting green, practice bunker, and two practice holes.
The Harry Mussatto Golf Course currently serves a variety of clientele, providing instructional recreation services for the students at Western Illinois University along with the campus faculty and staff. In addition, the Harry Mussatto Golf Course is host to the WIU Men's and Women's Golf Team as well as several Intercollegiate Athletic Department events. The golf course is the primary public golf facility in the city of Macomb.


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