text:
Women who have survived breast cancer may have to fight another killer down the road -- heart failure, researchers report.
They found a much higher rate of heart failure among breast cancer survivors than has previously been reported, and said their findings likely reflect the real-world risks that women have. The 12,000 women studied for the report had a 20 percent risk of developing heart failure over just five years if they got a common chemotherapy regimen, compared to just 3.5 percent of breast cancer patients who did not get chemo.
"I think these drugs are critical to improving breast cancer survival," said Erin Aiello Bowles of the Seattle-based Group Health Research Institute, who led the study published in the Journal of the National Cancer Institute. "But these drugs are toxic. They are meant to target disease but they can often damage other parts of the body."
Clinical trials of breast cancer patients -- designed to discover whether drugs fight disease and to show how safe they are -- have shown that the drugs can damage the heart and cause higher rates of heart failure. They generally demonstrate about a 4 percent increase in heart failure over three to five years for women getting chemo. But clinical trials usually involve a select group of patients who are healthy in other ways.
Bowles said her team set out to look at real-world patients of all ages and with a range of health conditions on top of their breast cancer. They went through the medical records of women at eight health systems who were treated between 1999 and 2007 with two very common cancer drugs: a group of drugs called anthracyclines, such as adriamycin, and a targeted antibody drug called Herceptin or trastuzumab.
Each drug raised the risk on its own, but the combination greatly raised heart failure rates.
"It is important to note that these rates do vary by age," Bowles said in a telephone interview. "They are much lower in the younger women." More than 40 percent of the women over the age of 75 who got a combination of an anthracycline and Herceptin also developed heart failure within five years. Just 13.7 percent of the breast cancer patients that age who did not get chemo developed heart failure.
The study highlights a growing problem. The American Cancer Society estimates there are 12 million cancer survivors alive in the United States now. As many cancer patients survive their disease and lead ever-longer lives, they find they must fight second battles against the long-term effects of the treatments that saved their lives. Even so-called targeted therapies, which were designed to better target tumor cells while leaving healthy tissue alone, have been shown to cause long-lasting damage.
And as they leave the care of a specialized oncologist and return to day-to-day care, they may not know they're at special risk of other conditions – and their primary care doctors may not be aware, either. The American Society of Clinical Oncology has been warning about the problem for years, and released research at its annual meeting last June showing that 94 percent of primary care doctors didn't know about the potential long-term effects of drugs commonly used to treat breast and prostate cancer.
Breast cancer is the leading cancer killer of U.S. women, after lung cancer. It is diagnosed in more than 220,000 women a year, according to the American Cancer Society, and will kill nearly 40,000 this year. About 20 percent of cases are a kind called HER-2 positive, and Herceptin was formulated to especially target this kind. It's very effective and has saved thousands of lives, but it was known to also damage the heart, although doctors don't understand just how.
Heart failure is also very common. The National Heart, Lung and Blood Institute estimates 4.8 million Americans have congestive heart failure, which is a chronic condition in which the heart doesn't pump blood effectively. Half of patients with heart failure die within five years, and 400,000 people get newly diagnosed every year.
So what can women do if they've had chemo for breast cancer and want to watch their hearts?
Cardiologist Dr. Larry Allen of the University of Colorado in Denver, who also worked on the study, said they first of all need to be educated about what drugs they have taken and what the side-effects are.
"Second, patients should ask about what heart tests may be indicated before, during, and after treatment," Allen said in a statement. These may include tests of how well the heart is pumping blood – tests that most women won't get during a routine physical or well-woman visit.
"Third, in addition to allowing doctors to monitor for heart problems, patients can monitor themselves for worsening heart function by understanding how heart problems may present -- including shortness of breath especially when lying flat, leg swelling, palpitations/heart fluttering, and exercise intolerance (these symptoms can represent non-heart disease too, but generally warrant additional evaluation)," Allen added.
"Unfortunately, it is unknown if medications that are typically used to treat heart failure (such as beta-blockers and ACE inhibitors) might protect against heart damage from certain chemotherapy."


text:
About Me
- Rose Rock Photography
- Please visit our new website at www.roserockphotography.com We offer unique photography services where the focus is on a photojournalistic approach to our subjects. We like to capture moments as they happen so that our clients can treasure them for a lifetime! We take pride in offering a variety of photography services at INCREDIBLY competetive prices! We look forward to capturing those unforgetable moments with you! If you have any questions, please contact us at email@example.com or
Sunday, December 16, 2012
A Little Bridal Fun...
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subset: commoncrawl


text:
Strange dreams of no particular significance
I rarely remember my dreams more than a few seconds after I wake.
However, last night I had a long dream (or so it seemed), and I clearly remember its theme. I was engaged to marry Dave, whom I had a crush on through most of my grade school and high school years.
Where was my real-life husband of 29 years, Dave's wife of 35+ years, and the children of our two marriages? Apparently they didn't exist! Dave was young, tall, and handsome, and I was young again, too.
Here is a curious detail I remember. I told Dave, "I knew your mother." I offered that to him because I knew he would value it. In real life, his mother passed away about 15 years ago.
I don't attach any meaning to this dream, except that my subconscious still remembers my emotions of forty-some years ago. It was entertaining -- especially the part where our engagement was announced in the front page headlines of my hometown newspaper. Wow!
This dream about an old infatuation brought to mind another oddly vivid dream I had a few years ago. It was about a nice guy whom I dated for a few months, many years ago.
In my dream, I chanced to meet him, and he was genuinely glad to see me. He put his arm around my shoulder and gave me a squeeze. That made me happy, and I thought, "We're still friends after all these years."
By pure chance a few days later, I read on the internet that he had passed away. It was a great shock to me. I don't think he was even 50 years old. He died several months before my dream about him. I suppose it was all just a coincidence.


text:
U.S. Equal Employment
Opportunity Commission
EEOC Sued After Superintendent Frequently Used Racially Derogatory Terms, Hanging Noose Found at Worksite; Order Follows Jury Verdict of $200,000
SAN ANTONIO -- A federal judge has ordered AA Foundries, Inc., a local San Antonio manufacturer of ferrous castings and producer of foundry mold machines, to implement extensive measures to prevent racial harassment, the U.S. Equal Employment Opportunity Commission (EEOC) announced today. The EEOC had charged in the underlying lawsuit that African-American employees at AA Foundries routinely experienced racially offensive treatment. The order follows a jury award of $200,000 in punitive damages to three former employees of AA Foundries.
The jury had found that AA Foundries subjected three African-American employees to a racially hostile work environment, and that the highest ranking official at AA Foundries' San Antonio plant, Superintendent Ronnie Hunt, acted with malice or reckless indifference to the rights of the workers not to be subjected to insults and intimidation. Subsequently, on October 9, 2012, the court granted the EEOC's post-trial request for a permanent injunction against future discrimination.
"We are very pleased with the court's decision, which will protect employees from future harassment or discrimination," said EEOC General Counsel David Lopez. "We hope this judgment serves as a wake-up call for employers who ignore or condone this kind of behavior in the workplace."
The judge and jury heard testimony at trial that Superintendent Hunt not only used the "N" word, but also called adult African-American male employees "mother-f---g boys," posted racially-tinged written material in the break room, and routinely slandered them referring to them as "you people" and accusing African-Americans of always stealing and wanting welfare. After several employees filed racial harassment charges with the EEOC, a noose was displayed at the AA Foundries workplace. In response to employee complaints about this noose, the superintendant described such reports as "BS" and stated the noose "was no big deal" and that the complainants were "too sensitive."
On the witness stand, Hunt denied that racial harassment occurred at AA Foundries, and maintained that AA Foundries had done nothing wrong. He also admitted that it did not bother him to hear racially derogatory language at the plant. At the time, there was no effective company policy to address racial harassment according to the EEOC. Hunt's testimony and the lack of procedures for complaints compelled the EEOC to petition the district court for an injunction to address these policy deficiencies.
Racial harassment violates Title VII of the Civil Rights Act of 1964. The EEOC filed suit after first attempting to reach a pre-litigation settlement through its conciliation process. The EEOC filed suit against AA Foundries in 2011 in U.S.
District Court for the District of Western District of Texas, San Antonio Division (EEOC v. AA Foundries, Inc., Civil Action Number 5:11-cv-792).
Stating that "the Court is convinced that injunctive relief is necessary in this case," U.S. District Judge Harry Lee Hudspeth granted the EEOC's request and issued an order permanently enjoining AA Foundries from engaging in any employment practice which facilitates, condones, or encourages a hostile work environment based on race, or from engaging in any other employment practice which discriminates on the basis of race. Adopting most of the EEOC's proposals, the court further ordered that AA Foundries must develop a policy and procedures for handling reports of racial harassment; develop an effective investigation process for all complaints of racial harassment; distribute a written policy and provide equal employment opportunity training to all employees, including managerial employees. The EEOC will monitor compliance with the judge's order.
"Today, the court has affirmed the importance for all employers to have effective policies and procedures in place to prevent discrimination in the workplace," said Judith G. Taylor, supervisory trial attorney for the EEOC's San Antonio Field Office. "A strong policy, meaningful training and a swift response to complaints are a company's most effective tools for addressing an existing hostile work environment or to prevent one from arising. The Judge's order will go a long way toward protecting AA Foundries' employees from harassment."
Eduardo Juarez, senior trial attorney in San Antonio, said, "While we are able to resolve most of our litigation through settlement, this case illustrates the EEOC's commitment to litigating cases when necessary to vindicate the public interest. The objective of every EEOC case, whether large or small, is the same: to make equal employment opportunity the reality in the workplace."
The EEOC enforces federal laws prohibiting employment discrimination. Further information about the EEOC is available on its web site at www.eeoc.gov.


text:
Holbrook Disc Jockeys (DJs) -
events for Weddings & more in Holbrook NY
Since 1996 DJ Joey B has been serving the hudson valley region. Each party is customized by DJ Joey B. Weddings,Sweet 16's,Birthdays,School dances,Class reunions,Out door events. Big screen video,lcd... more dj info
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Professional DJs specializing in Weddings, Bar Bat Mitzvahs, Sweet 16s and Corporate events. Your one stop shop for entertainment. Serving the Hudson Valley with a staff of entertainers with over 30... more dj info
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text:
Dr. Douglas Stewart reviews medical content for Healthwise, a
nonprofit organization with a mission to help people make better health
decisions. Dr. Stewart is a Professor in the departments of Medicine and
Oncology, Divisions of Medical Oncology, Hematology, and Hematological
Malignancies at the University of Calgary in Calgary, Alberta, Canada. He is also a Medical
Oncologist in the Department of Medicine at the Tom Baker Cancer Center and the
Calgary Health Region in Calgary, Alberta.
MD: University of Alberta,
Edmonton, AB, 1987
Fellowship in
Bone Marrow Transplantation and Lymphoma: University of Nebraska, Omaha, NE,
Internal Medicine, Royal College of Physicians of Canada
Medical Oncology, Royal College of Physicians of Canada
University of Calgary, Calgary, AL:
Dr. Stewart has received research funding and honoraria from Hoffmann-La Roche.
Healthwise Staff
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
WATCH: A Brief History of the Wrong Winners Being Crowned
The accidental crowning of La La Land as Best Picture instead of Moonlight was one of the most high-profile mess ups in decades. But it certainly wasn't the first.
Watch Now
- The 13 Most Withering Insults on 'Big Little Lies'
- Tom Kenny Explains Various SpongeBob Memes
- How Realistic Is Hollywood's Depiction of Women in Media?
- Christina Applegate Explains the Backstory of Jen's Mastectomy on Dead to Me
- How Timothy Simons Handles All the Insults on Veep
- Sutton Foster Gushes Over Younger Director Miriam Shor
- The Team Behind I Am the Night on Why It's So Universally Resonant
- The Cast of Miracle Workers Plays a Round of Catch Phrase
- DeWanda Wise on Preparing for Her Role in She's Gotta Have It
- The Women of One Day at a Time Ship Penelope and Schneider's Relationship
- Here's What Went Into Filming Camping Episode of Project Runway
- Linda Cardellini Is Good at Keeping Secrets
- Natasha Rothwell Channels Her Inner Nancy Meyers
- Anna Konkle and Maya Erskine on Why Pen15 Is So Relatable
- Niecy Nash Critiques Iconic Nails
- Eric McCormack on What Society Expects From Sitcoms
- Behind the Infamous Romper Scene in The Marvelous Mrs. Maisel
- Lily Collins on the Importance of Strong Female Story Lines
- Christina Hendricks and Retta Play the Newlywed Game
- Why Christopher Abbott Read Catch-22 Twice Before Filming


text:
Pogi0602 brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 52 Designs von 14 Designern wurde eine Gewinner gewählt.
Pogi's (sub title: "Fire-Grilled Pizzas")
Pogi's s a mobile food trailer servicing businesses and office complexes in the Salt Lake City area. We serve fire-grilled pizzas, salads, dessert and drinks.
I feel we are unique because we are able to make a fresh pizza, made to order in less than three minutes.
Pogi's is a fun environment, were people can hang out listen to music and socialize without the restrictions of an indoor restaurant.
Business Professionals both young and old looking for a quick fresh meal for a good price. Someone that may not want to get in their car and deal with traffic or the line at a restaurant.
Pogi's is looking for those people that are willing to try something new.
Pogi's also caters to those businesses that may not want there employees out on a long lunch break, which in-turn improves work output and wasted time.
1. A logo that would look good on an orang trailer.
2. A logo with the sub title "Fire-Grilled Pizzas"
3. The typeface should be clear, simple and bold. We want something that stands out.
4. Fancy is ok. We want people to feel comfortable ordering food from a trailer.
Logos I like: http://www.cpk.com/
Finden Sie heraus, wie ein Designwettbewerb funktioniert, oder lernen Sie mehr über unsere Logo-Design-Angebote.


text:
I've been fostering this guy for several months now, and I can't believe he hasn't gotten a single adoption application!! He is the perfect puppy - no issues: great with other dogs and cats, great with people, house trained, crate trained, extra adorable... someone adopt my foster dog! I'm willing to drive him pretty much anywhere. More info on his petfinder page: http://www.petfinder.com/petdetail/26428221/
Here's a video of him sitting: https://www.facebook.com/photo.php?v=10100120528856134&l=787105672258933803
Look, I'm only 37lb and full-grown; doesn't someone want a pocket pit?
How could you resist my EARS?
Adopt me!!
More photos available here: https://www.facebook.com/media/set/?set=a.992255015964.1073741835.13300878&type=1&l=15d9af7af9
Adorable Chocolate Bat-Eared Rescue Puppy Seeks Forever Home
Why buy from a breeder when there are plenty of homeless pups in shelters???
4 posts • Page 1 of 1
- Sierraraptor
- Newborn Bully
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Re: Adorable Chocolate Bat-Eared Rescue Puppy Seeks Forever
He's sure a cutie!
- ilovetyson
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Re: Adorable Chocolate Bat-Eared Rescue Puppy Seeks Forever
awwww He is a cutie for sure! We have had some AWESOME Dogs sit for MONTHS! But, just means there family hasnt met them yet <3 Good luck to him!
Re: Adorable Chocolate Bat-Eared Rescue Puppy Seeks Forever Home
He is such an adorable dog.
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iExplorer 188.8.131.52
iExplorer 188.8.131.52 | 12.1 Mb
iExplorer is the ultimate iPhone, iPad and iPod manager, it lets you easily transfer music from any iPhone, iPod or iPad to a Mac or PC computer and iTunes. You can search for and preview particular songs then copy them to iTunes with the touch of a button or with drag and drop.
Intelligently Transfer Music to iTunes
iExplorer lets you easily transfer music from any iPhone, iPod or iPad to a Mac or PC computer and iTunes. You can search for and preview particular songs then copy them to iTunes with the touch of a button or with drag and drop. Looking to transfer more than just a few tracks? With one click, iExplorer lets you instantly rebuild entire playlists or use the Auto Transfer feature and copy everything from your device to iTunes.
Export iPhone Text Messages
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John Muir Award
Our engagement initiative encourages people to connect with, enjoy, and care for wild places.
It's an environmental award scheme for people of all backgrounds – groups, families, individuals. It's non-competitive, inclusive and accessible.
- Read a brief introduction.
- Watch a 10-minute film.
- Download an Information Handbook for detailed guidance.
- View a wide range of resources and case studies.
- Find out more about John Muir.
If you have questions about your John Muir Award during this unprecedented time please click here to read our updated FAQs. If you would like to read how the John Muir Trust is responding to the pandemic please click here.
Four Challenges lie at the heart of the John Muir Award
Discover a wild place
This can be school/centre grounds, local park, beach, woods, river, mountain or national park.
Explore it
Do things to increase awareness and understanding. Experience, enjoy and find out more about your wild place(s).
Conserve it
Take some practical action and personal responsibility.
Share your experiences
Let others know about them, what's been achieved, what's been learned.
The John Muir Award is supported by
Thank you to all those individuals and organisations who have already supported the John Muir Award. Make a donation to our John Muir Award Fund today to help more people connect to wild places.


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Rich chocolate ganache, hazelnut, crisp wafer and vanilla ice cream, encased in a dark chocolate sphere, melted with hot white chocolate sauce. Excellente! (v)
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Rich chocolate ganache, hazelnut, crisp wafer and vanilla ice cream, encased in a dark chocolate sphere, melted with hot white chocolate sauce. Excellente! (v)
Rum-soaked sponge, black cherries in Kirsch and whipped cream (v)
Vanilla cheesecake mousse, Demerera crumb and Herefordshire blackcurrants, encased in white chocolate and raspberry bark (v)
with Belgian chocolate sauce and Bourbon vanilla ice cream (v)
served with home-baked sultana & oatmeal biscuits (v)
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Lemon mousse roulade rolled in raspberry sugar crunch, topped with vanilla ice cream and flamed meringue, served with fresh strawberries (v)
topped with a Demerara crumb, served with vanilla (v) or soya custard (ve)
with Bourbon vanilla ice cream (v)
with Herefordshire blackcurrants and vanilla custard or ice cream (v) Vegan alternatives available
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Shepherds Purse Yorkshire Blue, Lubborn Somerset Camembert, Belton Farm Red Leicester and Isle of Man vintage cheddar with a selection of Fudge's nut & mixed seed biscuits, grapes, celery and chutney (v)
Choose from home-baked chocolate brownie, white chocolate & blackcurrant cheesecake tower, apple, plum & damson crumble or Belgian chocolate & hazelnut mousse (v) Mini desserts are 350kcal or less


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Engineers can find themselves working in many different disciplines and environments, from overseeing maintenance operations to designing and building engineered solutions, the range of career options is vast, varied and challenging.
The Diploma of Engineering offers students an industry-connected experience, uniquely placed to provide solutions to the challenges faced by the global community. Curtin College will provide you with the skills and knowledge to enable you to commence the academic studies you will need for your career in engineering.
Leading to:
Bachelor of Engineering (Honours)
Available Majors include:
- Chemical Engineering (Chemical stream OR Oil and Gas stream)
- Civil and Construction Engineering
- Electrical and Electronic Engineering
- Industrial and Systems Engineering
- Mechanical Engineering
- Mechatronic Engineering
- Mining Engineering
- Metallurgical Engineering
- Petroleum Engineering
Careers include:
- Aircraft Engineer
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- Chemical Engineer
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- Mechanical Engineer
- Mechatronics Engineer
- Metallurgical Engineer
- Minerals and Mineral Process Engineer
- Mining Engineer
- Petroleum Engineer
- Product Quality Controllers
- Production Engineer
- Quality Controller
- Renewable Energy Engineer
- Telecommunications Engineer
Your Engineering Pathway
If you have…
✓ Completed Year 12 with an ATAR (or the equivalent in your country).
Diploma of Engineering (Stage 2)
9 university-level units studied over 2-3 trimesters. Equivalent to Year 1 of the corresponding Curtin degree.
Direct Entry into Year 2 at Curtin University.
Bachelor of Engineering (Honours).
Or if you have…
✓ Completed Year 11 (or the equivalent in your country).
Diploma of Engineering (Stage 1)
8 pre-university level units are studied over 2 or 3 trimesters.
Diploma of Engineering (Stage 2)
Equivalent to year 1 of the corresponding Curtin Bachelor Degree.
Diploma of Engineering Units (Stage 1)
CRICOS Code 087941B
Students must complete the following seven core units and one elective unit:
Core Units
- Academic Communication Skills
- Academic Research & Writing
- Chemistry
- Essential Mathematics
- Technical Mathematics
- Physics
- Programming
Elective Units (Select one)
- Accounting
- Design Skills
- Economics
- Human Biology
- Introduction to Design Skills
- Information Media Technologies
- Media Culture & Communications
- Management
- Marketing
- Project Management
Diploma of Engineering Units (Stage 2)
CRICOS Code 087941B
Students must complete the following core units:
Core Units
- Academic Communication
- Electrical Systems
- Engineering Foundations: Design & Processes
- Engineering Foundations: Principals Communication
- Engineering Materials
- Calculus for Engineers
- Linear Algebra and Statistics for Engineers
- Engineering Mechanics
- Engineering Programming
Engineering Diploma of Engineering (Stage 2 Units)
Stage 2 Units – 25 Credit Points Each (unless stated)
Academic Communication (12.5 credit points)
This unit is specifically designed to develop key communication skills. The aims of this unit are to develop students' understanding of, and skills in: critical reading, including note-taking, summarising and evaluating arguments; team-building and team-work skills; academic writing skills including paraphrasing, quoting and referencing; report writing; delivering oral presentations; academic writing style.
Calculus for Engineers
This unit builds on students' knowledge of functions and calculus, further extending to a range of techniques used in solving problems arising in engineering and related fields. Students will extend their differentiation techniques to optimisation problems and the approximation of functions. This unit will cover a range of integration techniques to optimisation problems and the approximation of functions. Students will apply integration techniques to find volume, length and surface area and will be introduces to the concept of complex numbers, together with their applications and use in solutions to polynomial equations. This unit is designed for those students who have passed WACE Mathematics Methods or equivalent.
Engineering Foundations: Design and Processes
Design horizons. Effective teams. Requirements specifications; identifying features. Systems design; creative thinking methods for innovative solutions. Conceptual design. Design specifications; setting priorities. Ethics and design. Operational design; reliability, sustainability, ergonomics. maintainability. Economics of design. Social and professional responsibilities. The concept of concurrent engineering. The future; computer-aided design. Report writing within engineering academic and professional contexts. Developing reflective learning and oral communication skills.
Engineering Foundations: Principles and Communication
Structure of the engineering industry. How engineering works. Working as an engineer. Engineer's responsibilities and duties. The engineer and the environment. Working in a team. Academic writing and ethical scholarship. Report writing within engineering academic and professional contexts. Developing reflective learning and oral communication skills.Compliance with procedures.
Engineering Materials
Structure of atoms, quantum numbers Interatomic bonding Atomic coordination, Interatomic distances, Atomic and ionic radii, Coordination number Crystal structure, Non-crystolline structures. Gases. Liquids, Glosses Imperfections and atom movement. Solid solutions in metals andionic, compounds, Point defects. Line defects. Boundaries. Atomic diffusion Electronic structures. conductivity, insulators. semiconductors. electronic resistivity vs temperature. Electronic energies. Energy bands Magnetic behaviour. Ferromagnetism. Superconductivity Introduction to Organic Chemistry, Alkanes, Alkenes and alkynes, Benzene and aromaticity, Functional groups and reactivity, Electrochemistry, Electron transfer reactions. Electrochemical cells. Reduction potentials. Corrosion processes and theory, Corrosion testing. data interpretation, mechanical testing Elastic and Plastic Deformation, Slip Systems and Dislocation Theory, Fatigue and Fracture, Tensile, Hardness, and Impact Tests, Corrosion Prevention and Control Metals and Alloys, Microstructures, Equilibrium diagram construction. Phose Equilibria, Microstructure and Heat Treatment. Metallography and Heat Treatment. Polymers. Ceramics and Glasses. Materials Selection, Case Studies, Composite Materials, Semiconductor.
Engineering Mechanics
Newton's Laws; Forces as vectors. equilibrium of concurrent and non- concurrent forces; Couples and distributed forces. Equilibrium of statistically equivalent systems; Free bodies and free- body diagrams; Analysis of simple frameworks, trusses; Internal actions within a beam using free-body diagrams; Variations in resisting forces along a beam; Relationship between load and response; Axial stress and strain, elasticity; Axial deformation; Shear stress and strain, shear modulus; Deformations in shear; Thermal effects and resulting stress and strain; Principles of compatibility; Concept of stiffness and properties of area and material that influence response; Superposition; Kinematic equations; Linear motion; Projectile motion. Curvilinear and relative motion; Plane kinetics, Newton's second law in n-t coordinates; Linear momentum; Elastic and inelastic collisions. Work, forces and power; Potential and kinetic energy; Elastic energy; Energy conservation; Plane kinematics and kinetics of rigid bodies; Rotation about a fixed axis. Hydrostatic pressure; Static fluid forces on simple structures; Analysis of fluid; Momentum flux of all fluid flows. Bernoulli's equation.
Engineering Programming (12.5 credit points)
The need for and importance of writing computer programs, sequencing the solution of a problem of sub-activities/instructions. Designing an algorithm. Practical programming in 'C' (the vocabulary, the grammar and the structure)- input-output. storage and assignment, single-path programs, logic statements. loops and arrays. Scientific and engineering libraries of routines, compilation and de-bugging; validation.
Electrical Systems
Fundamentals of DC Circuits; Fundamentals of AC Circuits; Electro-mechanics and Energy Conversion; Electronics; Instrumentations and Control.
Linear Algebra & Statistics for Engineers
This unit will consider the problems arising from engineering-related fields. Students will learn the necessary skills to model and solve such problems through the introduction of mathematical techniques of linear algebra, data analysis and statistical inference. This unit will cover vectors, lines and planes and their extension into n-dimension space. The unit also covers matrices and their use for solving systems of linear equations through a study of a number of different types and solution methods. Students will be introduced to the world of statistics by looking at the concepts of descriptive statistics and inferential statistics.
Engineering Evening Tours
Gain an insight into how Curtin are producing better engineering for the future with nationally award-winning, multimillion dollar facilities and excellent teaching capabilities. Ask Curtin College.
2020 Fees
Australian Students
|Per Unit
|Total Fees ($AUD)
|Diploma (Stage 1)
|Diploma (Stage 2)
International Students
|Per Unit
|Total Fees ($AUD)
|Diploma (Stage 1)
|Diploma (Stage 2)
Entry Requirements
Australian Students
|Entry Requirements
|Diploma (Stage 1)
|Year 11 with 50%
|Diploma (Stage 2)
|Minimum ATAR 60 OR equivalent Foundation Year grades
International Students
|Diploma (Stage 1)
|Diploma (Stage 2)
|General Certificate of Education (GCE)
|GCE O-Level with 4 passes
|Minimum of 4 points from 3 GCE A-Level
|International Baccalaureate (IB)
|Completion of Year 1 Diploma with at least 18 points (minimum of 4 subjects)
|Minimum of 22 points over 6 IB units in one sitting
|Global Assessment Certificate (GAC)
|Enquire at Curtin College
|Enquire at Curtin College
For more information about entry requirements and pre-requisites for Australian and International applications:
We accept students from a variety of academic backgrounds, as well as students who have completed alternative training. We also accept students with work and/or life experience:Entry Options Student & ATAR Profiles
Diploma of Engineering (Stage 2)
February | June*
Diploma of Engineering (Stage 1)
February | June | October
* This excludes the majors 'Chemical Engineering (Oil & Gas)', 'Metallurgical Engineering' and 'Civil & Construction Engineering' which only have a February intake for the Diploma (Stage 2)
Diploma of Engineering (Stage 1)
2 or 3 Trimesters (8 – 12 months)
Diploma of Engineering (Stage 2)
2 or 3 Trimesters (12 months)
This is a full-time course at Curtin's Bentley Campus
Next Intake February 2020
Apply now for Diploma of Engineering and you could be on your way to year 2 of the Bachelor of Engineering (Honours) at Curtin within 12 months.Apply Today
What Our Students Say
Engineering student Merlene Widjaja talks about how she has succeeded at Engineering.
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Curtin Engineering offers you an industry connected education experience that is uniquely placed to help provide solutions to the challenges faced by the global community.
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For creative people with an interest in improving living conditions, urban developments, construction and environmentally friendly design.
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The Faculty of Humanities is comprised of four schools. Each school has multiple departments which specialise in a wide array of degrees.
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Get the skills and knowledge you need for a successful career in the rapidly evolving information and communications technology industry.
Postgraduate Preparation Program
Completion of the PPP will result in direct entry into the Curtin College Graduate Certificate program.
Graduate Certificate
If your Bachelor Degree does not qualify for direct entry into a Curtin University Master Degree, the Graduate Certificate is your alternative pathway.


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As requested, some pictures:
Before... (old bolster upholstery.)
The lower motherboard in the master section looks like it had some bad dental work done by the previous owner(s) but it beeped out fine!
in progress...
Some of the mic pres have this type of mod. Jim Williams, is this similar to what you've described?
Family portrait :-) JH 110 C from 1984 in decent shape! It will be the next project...
I re-capped re-socketed and re-chipped the Master and Monitor Module- with the exception of the tantalums. The distortion is still in the 2Mix output, but not when patched from Stereo Out to Aux in. Could it be the tantalum caps? The master fader? Or perhaps one of the J111s?
Jim, I'm moments away from sending my other Master module to you to work your magic, and then I might have both flavors available...
Thanks to all for your interest, advice and encouragement!


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Since Ben Folds' ego apparently decided that his already indulgent band name was precisely one word too long after 1999's underrated ...Reinhold Messner, he's since softened into a yawning blandness, swiftly shedding relevance until a leak of his most recent solo LP was so poorly received that fans were convinced it simply had to be a joke. (As it turned out, they were right, but the real punch line was yet to come: the real thing turned out to be even weaker than the 'joke'). The more quasi-mature Folds became, the further away from his artistic or commercial zenith he wandered, and with erstwhile Ben Folds Five members Jessee and Sledge doing whatever the hell they've been doing since, a cynic would hardly wonder why the trio felt like it was a good idea to get the band back together, man.
It'd be wrong of me to pretend that the prospect of the Five getting back together didn't get me excited – and there's undoubtedly a real twinge to be felt the first time you hear Jessee and Sledge swoop in behind Folds with their unmistakable harmonies: it just feels right. And yes, to answer your only question, there's material on here which stands shoulder to shoulder with the chemistry of old – the chorus of 'Draw A Crowd' is as irresistibly carefree as it is melodically robust, while the talky 'Do It Anyway' finally sees Folds integrate himself into an ensemble of equally weighted players for the first time in many self-centred years – Sledge's fuzzy bass wandering under the keys with Jesse's loose stomp; Folds providing the sort of restless one-off flourishes that he used to deliver so well (just listen to how he wanders off to some sassy jazz trills for just one line of the second verse – responding to the jam, sounding, at long last, again part of a band).
But sadly, the album at large is plagued by many of the things which have seeped into Folds' sound over the last ten years: the seriousness, the restraint, and the descent into middle age. Put bluntly, the Five sound old here, a little out of touch and, more damagingly, far too restful. One of BFF's greatest legacies was to have excavated the piano as the rock instrument that it both can be and should be. Folds has since spent a decade abandoning that repositioning of the ivories, dragging his sound towards a Radio 2 flavoured conventionality, and unfortunately even the reunion of the trio does far too little to rekindle the old energy. While his snotty punkrock snarl often led to uncomfortably juvenile bitterness ("give me my money back, you bitch") it's nevertheless easy to romanticise and justify all that when faced with the the nothing-is-happening balladry of tracks like 'Sky High'). You can almost see Sledge's eyelids drooping.
But for all his misguided mellowing of both sound and outlook, Folds has never been accused of being unable to turn a hook, and Sound Of The Life Of The Mind isn't going to begin that particular backlash, nor is it going to wholeheartedly disappoint those who wanted their Five nostalgia itch scratched. But sadly, perhaps even inevitably, it's a reunion which is ultimately infected by everything there is to lament about Folds' ten year solo career, and – despite bringing Sledge and Jessee back into the groove – continues Folds' particularly unwelcome insistence on putting himself more and more squarely in the centre of the arrangements, even as his song writing and piano playing becomes more and more pedestrian.
6Russell Warfield's Score


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All News Releases By Date
EPA Finalizes Greenhouse Gas Permit for West Texas Power Plant; $104 million in economic development and increased jobs
Release Date: 08/06/2014
Contact Information: Jennah Durant or Joe Hubbard, email@example.com or 214 665-2200.
DALLAS – (Aug. 6, 2014) The U.S. Environmental Protection Agency (EPA) has issued a final greenhouse gas (GHG) Prevention of Significant Deterioration (PSD) construction permit to the Invenergy Thermal Development LLC, Ector County Energy Center, Ector County, Texas. The company plans to construct a new simple-cycle power generation facility.
"Facilities like Invenergy's show Texas can provide power while cutting greenhouse gas emissions," said Regional Administrator Ron Curry. "Taking advantage of clean-burning natural gas is a win for business and the environment."
The company will construct two natural gas-fired simple-cycle combustion turbines at a new facility in Goldsmith, TX, near Odessa. The facility will house a natural gas-fired dew point heater, a fire water pump engine, and circuit breakers. Once completed, the turbines will provide 165 megawatts of electricity. The expansion will bring $104 million in economic development to the local area.
In June 2010, EPA finalized national GHG regulations, which specify that beginning on Jan. 2, 2011, projects that increase GHG emissions substantially will require an air permit.
EPA believes states are best equipped to run GHG air permitting programs. Texas is working to replace the federal implementation plan with its own State program, which will eliminate the need for businesses to seek air permits from EPA. This action will increase efficiency and allow industry to continue to grow in Texas.
EPA has finalized 51 GHG permits in Texas, proposed an additional four permits, and currently has 11 additional GHG permit applications under development in Texas.
For all of the latest information on GHG permits in Texas please visit: https://yosemite.epa.gov/r6/Apermit.nsf/AirP
EPA is taking a variety of actions to cut Greenhouse Gas emissions and address the impacts of climate change. Most recently, EPA released a Clean Power Plan for existing power plants to cut carbon pollution by 30 percent below 2005 levels. Learn more about EPA's actions at https://www.epa.gov/climatechange/.
Connect with EPA Region 6:
On Facebook: https://www.facebook.com/eparegion6
On Twitter: https://twitter.com/EPAregion6
Activities in EPA Region 6: https://www.epa.gov/aboutepa/region6.htm
# # #
Search this collection of releases | or search all news releases
View selected historical press releases from 1970 to 1998 in the EPA History website.


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Nationals ready to resume rivalry with Cards
WASHINGTON -- If you include Game 5 of the 2012 National League Division Series and last year's regular season, the Nationals have now lost eight straight games to the Cardinals following Thursday's 8-0 defeat in the opener of a four-game series.
Is it safe to a say the Cardinals have their number? The answer is no, according to Nats first baseman Adam LaRoche.
"My question is, how many games have we lost to St. Louis this year? It's a new year, we turn the page. We are 0-0 against St. Louis. We have haven't played them yet," LaRoche said prior to Thursday's contest at Nationals Park. "We have experienced some things with St. Louis that don't sit well with us."
The worst loss to St. Louis was arguably Game 5 of the NLDS on Oct. 12, 2012. The Nationals had a 6-0 lead and lost, 9-7. The game ended Washington's postseason run.
"I look back at a lot of those games and we beat ourselves," LaRoche said. "I think comparatively, we are right there with them and I would think they would say the same thing. If you want to look back, they have our number a little bit, but we are 0-0 [this year]."
Nationals manager Matt Williams gave the Cardinals credit for playing the game the right way. Entering Thursday's action, the Cardinals were 9-6 -- two games behind the Brewers in the National League Central standings.
"It starts with their rotation," Williams said about the Cardinals. "They have one of the best catchers [Yadier Molina] in the league and he runs a great game -- both offensively and defensively. They have power, they have some speed, they play exceptional defense. All of that combined is the reason they are at where they are at. Do we measure ourselves? I guess, yes, but ultimately we have to worry about ourselves and play the game the way we want to play it in order to have a chance to beat them."


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Abenhall,, Forest of Dean, Gloucestershire
Abercraf, Brecknockshire, South Wales
Aberdare, Rhondda Cynon Taff, South Wales
Abergavenny, Monmouthshire, South Wales
Abersychan, Torfaen, Gwent
Abertillery, Blynau Gwent, The Ebbw Fach Valley
Aberystwyth, Ceredigion, South Wales
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Awre,, Forest of Dean, Gloucestershire
Aylburton,, Forest of Dean, Gloucestershire
Bargoed, Caerphilly, Rhymney Valley
Barry, Vale of Glamorgan, South Wales
Beaufort, , South Wales
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Birchgrove, , South Wales
Bishopton, , South Wales
Blackwood, Caerphilly, South Wales
Blaenau Ffestiniog, Monmouthshire, Gwynedd
Blaenavon, Monmouthshire, Gwent
Blaisdon,, Forest of Dean, Gloucestershire
Blakeney,, Forest of Dean, Gloucestershire
Brecon, Brecnockshire, Powys
Bridgend, Bridgend County Borough, South Wales
Brithdir, , South Wales
Briton Ferry, , South Wales
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Cadoxton, , South Wales
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Cardiff Airport, , South Wales
Cardiff, Vale of Glamorgan, South Wales
Chepstow, Monmoutshire, South Wales
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Cockett, , South Wales
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Cowbridge, , South Wales
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Crickhowell, , South Wales
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Cwmbran, Torfaen, South Wales
Cwmcarn, , South Wales
Cwmdu, , South Wales
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Dingestow, , South Wales
Dyffryn Cellwen, , South Wales
East Aberthaw, , South Wales
Ebbw Vale, Blaenau Gwent, South Wales
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Port Talbot, , South Wales
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Raglan, Monmoutshire, South Wales
Rassau, , South Wales
Redbrook,, Forest of Dean, Gloucestershire
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Rhandirmwyn, , South Wales
Rhoose, , South Wales
Rhossili, , South Wales
Rhymney, , South Wales
Rogerstone, , South Wales
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Shirenewton, Monmouthshire, South Wales
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Skewen, , South Wales
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Soft, luminous finish.
Oil free.
Fragrance free.
(from Revlon)
oh yes, it's another HD foundation but this time...from a well-known drugstore brand, REVLON.
I've been using HD foundations eversince they came out in the market two years ago. My first hd foundation was that of Smashbox, and then I got MUFE next. From then on, everybody just seem to get addicted to achieving that flawless, airbrushed skin in front or behind cameras...of course, including me.
when this one from Revlon came out, it promises to be an alternative to those high end brands...this means achieving the same effect, if not better, at a cheaper price.
- consistency is like that of MUFE's and just like MUFE, it is easy to spread and blend
- light on the skin, not cakey
- offers medium to heavy coverage
- the pump dispenser! much, much hygienic as compared to some of their foundations
- a little goes a long way
- gives that poreless, airbrushed look! and i mean...really poreless!
- covers those nasty red marks
- gives you a bit of shimmery look, more like glowing
- no breakouts or any allergic reactions
- did not oxidize on me
- it has SPF but does not give off a white cast
- no smell
- cheaper than other well known brands that offer HD makeup line. it costs Php925 a bottle
(used concealer on the undereye area and sides of the nose and set with Photoready Powder in Fair/Light)
- didn't last that long on my skin. take note that I have super duper oily skin. so i guess this would work best on dry to normal skins.
- if you have oily skin, the "shimmer" can emphasize the oiliness
- i've found out that (for my skin) it is best to apply it with fingers then use a stippling brush after. of course, using your fingers on your clients is a no-no. i've tried applying it with a brush and it works just as fine. (but i still prefer using my fingers...LOL!)
- to make it longer lasting, i tried mixing it with their Colorstay liquid foundation and voila! not only did it minimized those shimmers, it also helped in making my makeup last the whole day.
- for those with drier skins, make sure to moisturize well
- for those with oily skins, use a good primer before applying this
- start with a thin layer and build the coverage if needed...in makeup, less is more :)


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Without efficient, easily running drains in the house, it would be tough to perform a variety of everyday jobs consisting of bathing, cleaning, dishes and numerous other typical tasks. Since of how crucial drains are, Drain Cleaning Renton recommends that there are numerous efficient factors to arrange a routine drain cleaning services.
It is simple to consider given the plumbing systems in our house. Sadly there are times when sinks and tubs establish persistent blockages that only an expert pipe cleaning can eliminate. Stopped up and sluggish moving drains can trigger discolorations on your sinks or tubs and will certainly even make your existing issue even worse, by additional obstructing your plumbing system to the point of failure.
We focus on pipe cleaning for all residential and commercial plumbing systems. We make certain that our drain specialists are completely trained to manage your pipe cleaning requirements. Our business has the experience needed to not just carry out pipe cleaning services in your house; we likewise can deal with other complicated plumbing and drain issues. Our plumbing services extend far past the conventional pipe cleaning.
We are a complete service plumbing and drain cleaning contractor that is prepared to assist you with even your most complex pipe and plumbing issues. We can offer services for everything from a small pipe cleaning to a significant plumbing system replacement.
Drain Repair Renton WA
Plumbing and pipes are an important part of our daily living. The system includes pipes, valves, assemblies and drain fittings, bringing clean drinking water into our houses and companies and getting rid of waste water. The water needs adequate pressure to transfer water throughout your home, consisting of washrooms, the cooking area, utility rooms, around corners, upstairs and to the outdoors yard hose. A pinhole leak in simply among these pipes can trigger countless dollars in damages and lost water.
Pointer For Healthy Drains and Water Pipes
Avoid putting food, grease or things down the drain. Water ought to run gradually down the drain. Bubbling noise or a sluggish drain is typically indicators of clog.
If you think a leak, guarantee they are right away repaired. Routine check your house, under sinks, outside landscaping, appearance for warm locations on the floor, listen for water running when there's absolutely nothing switched on. Little leaks can swiftly develop into huge troubles.
Look for deterioration, not just does it damage joints, fittings and plumbing pipes, it can likewise infect the water. Try to find green or orange spots around the fitting and shutoff valves.
Factors for Routine Renton Drain Cleaning
Less blockages – Normally, blockages in a plumbing system do not occur over night. Rather, they occur gradually gradually. Among the finest methods to make certain that those slowly-developing obstructions do not become real blockages is to arrange routine drain cleaning company. This will certainly enable us to see your house, clear out your drains and eliminate any issues prior to they really form.
Much better efficiency – Even if your drains are not totally obstructed, they might be beginning to slow down. If you see that your shower beginnings to fill a bit when you're in it or if your drains are not rather as quickly as they used to be, you might have some blockages establishing. By getting your drains cleaned you might be able to keep your drains working quick.
Much healthier pipes – Your plumbing system is even more than simply a random system of pipes and drains. It is really an extremely intricate system that has a fragile balance of pressure. As water flows in the pipes it will press air ahead of it and produce a vacuum of pressure behind it. There has to be vent pipes to enable this air movement. Blockages can trigger this system to get out of balance which will certainly minimize the efficiency of your drains. Cleaning your drains routinely will guarantee that this pressure balance remains undamaged.
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zzbird necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 137 diseños de 46 diseñadores freelance.
Ambassador Escrow
I am an experienced business builder launching a service product into a very competitive market with a goal of creating exposure and recognition of a brand. I want a company that is respected for it's character, professionalism, and customer care. We want to be memorable, but not in a cartoon-like way. We want to communicate trust, friendly, experience, respected, and reliable.
The target audience is 80% business to business. And 20% direct consumer target. The specific groups are industry vendor servicers, large financial institutions, and real estate professionals, as well as direct to consumer. The current market has plenty of competition, I am targeting contacts and relationships I have worked with for over 20 years, but not selling this particular service. The emphasis for our customers will be knowledge of their market and a professional, capable team.
Logo should be distinguished, clean, professional, memorable, and fresh.
You can be creative, avoid cartoons, and scroll like type face. I prefer simple, bold
Colors: like pure rich colors, blue, red, black, with white, yellow for contrast. Will certainly consider other combinations, this is where I look to your design abilities.
The uses will be Logo, Web site, branding, cards, stationery, marketing materials, and media
I will be checking submissions daily and providing feedback. Thank you!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Pacific Northwest's leading fly fishing blog with the latest information and fishing reports from various destinations around Oregon. Whether you like fly fishing for trout, steelhead, salmon, smallmouth bass, rockfish, carp, or various panfish; you have found the most informative blog to read up on for your fly fishing. Techniques, equipment, tips on fly fishing and many more topics will be on this blog, and most importantly there will be FISHING REPORTS.
Tuesday, May 17, 2011
Video - Summer Run Steelhead on the McKenzie or Middle Fork Willamette Rivers
Posted by Brian Marz at 5:49 PM
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brookfield, VT
There are no stowed away accuses of Pre-settlementfundingcom. Gave that you decide to ask for and are authorize for case sponsoring, going before truly submitting to financing you'll be given a clear and clear charge timetable indigent upon your solitary case, so you'll know accurately what sum you'll owe should just your case settles inside a specified time period. Everything is ahead of time and in plain, clear, tongue.
At Pre-settlementfunding.com, we grasp that honest to goodness development obliges a few speculation and money, and paying negligible respect to the likelihood that you win your case, you may not get the puts something aside for distinctive months or even years. The fact is that diverse individuals can't work after a harm, and can't resolve how to pay all their coherently requested living liabilities while merged in amplified arraignment. Puts off in court invigorate expanding cash recognized enthusiasm can recognize commitment or dispossession, and continually hassled get-togethers are constrained to acknowledge a settlement that is much lower than they shield. Presettlementfunding.com is around the nation's top settlement financing collaborations, and a trusted pioneer in regards to helping affronted social events who are obliging settlement of pending claims, allowing them to progression without money related burdens.
Settlement credits and case financing are wonderful tracks for bothered social events in need of cash distinguished help to get such move down without peril. Despite overheads realized with presettlement headways, the no-danger contemplate give satisfying decisions for disturbed social undertakings in need of cash. Constantly do your examination into the substance financing your settlement credits and case supporting. All fees/costs will be acquainted with you before confirming if the financing is the thing that you require. Furthermore, you will have no not precisely 72 hours to deny your agree to the financing offered, on the most fundamental level after you sign the appreciation. Naturally, your authentic guide will in like way be obliged to guarantee the financing extended.
Available mailing locations by zipcodes - brookfield
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First off, this is the best pancake recipe ever...it's Daddy's. Secondly, pancakes really ended up being a good toddler sous chef dish...until it came time to cook them on the hot griddle...had a few squeals until Miss Sous Chef was distracted enough not to care!
I put raspberries in mine and D had chocolate chips in his. So, confession time...I've never really eaten chocolate chip pancakes! Strawberry, blueberry...yes.
And I've MADE chocolate chip pancakes but never eaten them. Per D, no syrup needed. So, I tried! He's right! No syrup needed. It was pretty good. Not saying I'm going to convert my fruit to chocolate...but still good. As to Miss K, she was a fan of the chocolate chips and the syrup...with a few bites on pancake thrown in. :-) Now, heat up your griddle, grab your favorite sous chef, and cook something yummy! Here's the recipe if you're in the mood for pancakes!
1+ cups flour
1 T baking powder
Pinch of salt
1 T sugar
1 egg
2 T oil
½ cup buttermilk
½ cup milk - I added more...probably about 2-3 tablespoons
splash of vanilla, I don't know how much, just put some in
Add ins - fruit, chocolate chips, etc.
Sift together flour, baking powder, sugar, salt. In a separate bowl, whisk together the egg, oil and milks. Pour the wet ingredients into the dry and stir with a fork.


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From Proteopedia
Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0
Structural highlights
[INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].[1] [2] [3] [4] Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.[5] Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.[6] [7] Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.[8] [9] [10]
[INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Insulin is a key protein hormone that regulates blood glucose levels and, thus, has widespread impact on lipid and protein metabolism. Insulin action is manifested through binding of its monomeric form to the Insulin Receptor (IR). At present, however, our knowledge about the structural behavior of insulin is based upon inactive, multimeric, and storage-like states. The active monomeric structure, when in complex with the receptor, must be different as the residues crucial for the interactions are buried within the multimeric forms. Although the exact nature of the insulin's induced-fit is unknown, there is strong evidence that the C-terminal part of the B-chain is a dynamic element in insulin activation and receptor binding. Here, we present the design and analysis of highly active (200-500%) insulin analogues that are truncated at residue 26 of the B-chain (B(26)). They show a structural convergence in the form of a new beta-turn at B(24)-B(26). We propose that the key element in insulin's transition, from an inactive to an active state, may be the formation of the beta-turn at B(24)-B(26) associated with a trans to cis isomerisation at the B(25)-B(26) peptide bond. Here, this turn is achieved with N-methylated L-amino acids adjacent to the trans to cis switch at the B(25)-B(26) peptide bond or by the insertion of certain D-amino acids at B(26). The resultant conformational changes unmask previously buried amino acids that are implicated in IR binding and provide structural details for new approaches in rational design of ligands effective in combating diabetes.
Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues.,Jiracek J, Zakova L, Antolikova E, Watson CJ, Turkenburg JP, Dodson GG, Brzozowski AM Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1966-70. Epub 2010 Jan 25. PMID:20133841[11]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also


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The Stellar Story
Stellar Pizza, Ale, & Cocktails was established in 2001 when Stella Steadmon set out to create the kind of place she would like to frequent in her beloved Georgetown neighborhood. After searching for the perfect location for over 3 years, she found the Bertoldi building, which once housed Beannies Tavern and the original Georgetown Liquor. Along with several other buildings throughout Georgetown it is still owned by the Bertoldi Family today. The history and ambience of the building makes it the perfect place for an old-school pizzeria.
We are committed to using as many fine local ingredients and outstanding family-owned craft brews as we possibly can. We buy our sausage from the Cascioppo family in Ballard, and our bread from La Panzanella. We make our own dough & pizza sauce daily. All our food is made to order, and well worth the wait!
I hope that you, your friends, and your family will enjoy our food, beers & cocktails. ~~Thank you, and CHEERS!
- S.M Chriqui, Owner & General Manager
206 763 1660
Monday 11AM-10PM
Tues, Wednesday 11AM-10PM
Thursday 11AM-10PM
Friday 11AM-11PM
Saturday 11AM-11PM
Sunday 11AM-10PM


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Updated: Exposing SJP As a Terrorist Front at UC-BerkeleyBy Sara DoganSeptember 23, 2017UC-Berkeley: Promoting Jew-hatred and TerrorismBy Sara DoganMay 3, 2017Getting What You Wish for at Berkeley By George Will January 10, 2010 The Terror Legacy of the Left By Gary DeMar June 3, 2009 Stifling Pro-Israel Views at UC Berkeley By Reut R. Cohen May 1, 2009 A Tangled Web at Berkeley By John Ellis April 8, 2009 Berkeley's Idea of Tolerance By Ethel C. Fenig November 16, 2008 Am I Diverse Enough Now? By Andrew Quinio August 4, 2008 UC Berkeley's Friend of Bill Center Fronts for Islamic Terrorists By David Horowitz May 19, 2008 Palestinian Checkpoint on the U.C. Berkeley Campus By Zombietime May 7, 2008 Berkeley Schools Guilty of Race Discrimination? By Pacific Legal Foundation March 17, 2008 With Their Heads in the Trees By Debra J. Saunders December 4, 2007 My Call to the Left at UC Berkeley By Nonie Darwish October 25, 2007 Nonie Darwish vs. Berkeley Left on "Islamo-Fascism" (And Immigration) By Brenda Walker October 24, 2007 Carter Comes to Berkeley By Lee Kaplan May 8, 2007 Teaching Law-Breaking at UC-Berkeley By Lee Kaplan March 19, 2007 Affirmative Action Showdown By Heather MacDonald January 30, 2007 Hezbollah Groupie By James Taranto July 27, 2006 Back Down Memory Lane At Berkeley By Mark D. Tooley October 18, 2005 Mark Danner: Blaming America for the Global Jihad By Robert Spencer October 10, 2005 Berkeley's War Against Israel By Steven Plaut March 7, 2005
California's Betrayal of Academic Freedom By David Horowitz September 14, 2004 Coddling Campus Fascists By Sara Dogan June 30, 2004
UC Discriminates Against Asians By John Moores March 24, 2004
Time to Take a Stand Against Campus Terror By FrontPageMagazine.com February 17, 2004
Fascism at Berkeley By Cinnamon Stillwell February 16, 2004
Berkeley Anti-Semitism 101 By Dafka.org August 7, 2003 Race Still Divides Berkeley By Carrie Sturrock June 4, 2003 The Unpatriotic University: Berkeley By Erick Stakelbeck February 28, 2003 Robert Berdahl, Berkeley, and the Free Speech Movement By David Horowitz 2002
University of California, Berkeley
Berkeley, CA
Since Feb 14, 2005 --Hits: 61,630,061 --Visitors: 7,024,052
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Colchester 14°c
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Arnold stumbles toward regent finish line
Matt Arnold needs to drop out of politics for a few years, work hard and keep his nose clean, and maybe then he'll be ready for prime time. As it is, he just keeps embarrassing himself with his oddball antics while running for University of Colorado regent in the Republican primary.
His latest gaffe – posting on his web site the home addresses and contact information of several supporters of his opponent – is explained in this article by The Denver Post's Lynn Bartels, and a painful saga it is too. Every time Arnold steps into troubled waters, he offers an implausible explanation that only compounds the problem and further undermines his credibility.
On the other hand, what was Arapahoe County Sheriff Grayson Robinson doing calling Arnold about posting those addresses? It was perfectly legal to do so, whatever worries about possible harassment the individuals involved may have had. Robinson should stick to enforcing the law and let others enforce proper campaign etiquette.