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In the next few weeks I will be making a decision to purchase a MF system. I am looking into the the Aptus 65(not tested it yet) or a Phase P30 system(tested it).Are there any users of the Leaf Aptus 65 in the forum and can you share some of your experiences? Did you compare the A65 to the P30.I shoot lifetyle and people advertising work and although a full frame would be best, at this time I don't want to make that kind of investment.I currently use a Canon 1Ds MK2 & MK1 on the digital end. For film I mostly used RZ and Hassy 503 but no longer have an investment in them. I understand that both units require cables and adapters(RZ) so for this reason I will likely go with the Mamiya 645 option (not excited about).HiI rent the Aptus 22 for my mamiya 645 AFDII. This is an excellent back. What I have read and heard first hand is the DALSA chip in the 65 & 75 is a new generation DALSA chip. It has superior higher iso ratings 400 & 800. I have seen iso 400 files with the Aptus 75 and they were amazing!!! The Aptus 65 is the same chip only smaller in phyiscial size. As far as the Mamiya 645 AFD goes it is a great camera with excellent lens quality at a very good price. We have shot bill boards with this camera on the Aptus 22.Thanks Denis
Thank for your response Denis,What are you using to convert the Raw files the Leaf software or Adobe Camera Raw? Good to hear that the Mamiya is working out for you? The lack of WLF was a big turn off for me but so is cables hanging out of the camera on a Hassy 503. I don't care for the H1 and very expensive as well.Everyone seems to say that the A65 is a cropped A75 sensor and that the P30 is cropped from the P45, yet the at the same time they mention wide angle behavior on the smaller sensors is different because of the micro lenses in the sensor. It is very confusing and the only way is to try it for myself. I seek the opinions of the users in this forum since I have not been able to get a hold of an Aptus 65 and perhaps someone might have or is doing the same homework. I reached my limit of patience with the Canon 1DsMK2 and the countless hours of post processing is crazy.Thanks again,Oscarwww.oscarfalero.com[a href=\"index.php?act=findpost&pid=67442\"][{POST_SNAPBACK}][/a]
Thank for your response Denis,What are you using to convert the Raw files the Leaf software or Adobe Camera Raw? Hiwe use the Leaf software for processing. I am keen to try the RAW processor as it has been getting great reviews. It is a better proceesor for the ZD but it still needs a proper colour profile which is coming.the Leaf processor is excellent.thanks Denis
Everyone seems to say that the A65 is a cropped A75 sensor and that the P30 is cropped from the P45, yet the at the same time they mention wide angle behavior on the smaller sensors is different because of the micro lenses in the sensor. It is very confusing and the only way is to try it for myself. Thanks again,Oscarwww.oscarfalero.com[a href=\"index.php?act=findpost&pid=67442\"][{POST_SNAPBACK}][/a]
Oscar:The Aptus 65 is indeed a smaller version of the same chip in the Aptus 75. The P30, on the other hand, is a completely different chip than the P45, and different in a very significant way. You mentioned microlenses. The Aptus 75 and Aptus 65 do not have microlenses. Neither does the P45. The P30 does have microlenses. And if you intend to photograph with any type of camera movements, particularly at wide angle, youshould steer clear of the P30. The microlenses will present significant issues with color casts.To a lesser degree, you can also get color casts with P45's and the Leaf Aptus backs. However, Phase One uses Kodak sensors, Leaf uses Dalsa. Due to the sensor technology, specifically the depth of the photoreceptors, the Dalsa sensor is less prone to color casts when shooting wide angle or using camera movements.Steve HendrixPPR Digital[a href=\"index.php?act=findpost&pid=67494\"][{POST_SNAPBACK}][/a]
Steve I assume you have tested the aptus75 and 65. When using on a view camera, how much more limited are the movement capabilities with the 65. Mark[a href=\"index.php?act=findpost&pid=67643\"][{POST_SNAPBACK}][/a]
On the comment about color casts on BOTH chips the Kodak and Dalsa, I know that Phase One has a tool to take care of any cast if present and have also come up with new profiles 'easy gray' that take care of this , does Leaf have anything in thier software/hardware for correction of any casts?The best advice I can give is to test them both out yourself to see if you can live with any short comings from any back (there is not one magic bullet out there) . They are both good systems but what it comes down to is your preference of which file you like best and also workflow. A lot of these shoot-outs between competive products unless done by an independent third party are pretty much not worth anything except for scrap paper.M[a href=\"index.php?act=findpost&pid=67739\"][{POST_SNAPBACK}][/a]
I have had one on order since May 2nd. I was told a nother couple of weeks or so. SOrry i cannot help you yet. mark[a href=\"index.php?act=findpost&pid=67485\"][{POST_SNAPBACK}][/a]
When I started planning to upgrade from my 1Ds I rented Leaf 22 and P25 on Mamiya.I found the transition from Canon to Mamiya/Phase one fairly painless and ended up buying Mamiya/P30 ... there was a special offer on at the time. Another thing that helped me settle on Phase One was the Phase One local dealership seemed to offer a much better purchasing experience, giving me confidence that if there was a problem in the future they would get me working again quickly.I would say that after working with the Mamiya/P30 for a couple of months I am more that happy with the results and glad that I saved £8000 buying the P30 instead of the more expensive P45[a href=\"index.php?act=findpost&pid=68298\"][{POST_SNAPBACK}][/a]
Leaf shipped my back yesterday but unfortunately they goofed and sent it ground instead of 2 day air... so by next weekend...[a href=\"index.php?act=findpost&pid=67796\"][{POST_SNAPBACK}][/a]


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PDesign necesitaba un nuevo diseño de página web y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 11 diseños de 5 diseñadores freelance.
COA Network, developer of iTeleCenter
Established in 1992, iTeleCenter has become the industry standard for providing Advanced 800 Numbers at an affordable price. Our Award Winning Service has been featured in CNN, Microsoft Small Business, Yahoo! and Smart Biz. iTeleCenter has served over 50,000 small businesses, transforming the way they do business and helping thousands of clients portray a 'Big Business image while enjoying a Small Business Price.'
Our target audience is small to mid-sized businesses. We have a niche in providing service to many home based business as well as direct sales organizations. However, our product is designed for any company, large or small, looking for a streamlined phone image to present to their clientelle.
We are looking to establish ourselves with a bolder look and feel. Mainly, we feel our look right now is very cookie cutter and not very professional looking. This is the main improvement we are seeking. We would like to also see some different options on ways to layout the user experience on the page. It doesn't have to be in the order we currently have on our layout. We tend to stay in the blue family of colors to match our branding. However, we are open to trying other colors as long as it gives us a bold look. Below is a link to the landing page as it is now so you can get a feel for what content should be featured on it, but remember we really want to make this look more professional:
The only thing we would like is for the typeface to be clear, simple and bold. We want something that stands out. I would also suggest taking a look a the page below for some inspiration:
This is a competitor of our's.

subset: commoncrawl


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Clonidine and the Antidepressant Effexor Both Reduce Hot Flashes
October 9, 2011 by Robert Wascher
Filed under Antidepressant, Breast Cancer, breast cancer prevention, breast cancer risk, Cancer, Cancer Prevention, Clonidine, Effexor, estrogen, Hormonal Therapy, Hot Flashes, Menopausal Symptoms, Menopause, sex hormones, SNRI, SSRI, tamoxifen, Venlafaxine, Weekly Health Update
Welcome to Weekly Health Update
The blood pressure medication clonidine and the antidepressant venlafaxine (Effexor) both reduce hot flashes caused by breast cancer treatment and by menopause.
The modern management of breast cancer often includes "hormonal therapy," in which medications that block the effects of estrogen, or decrease the amount of estrogen manufactured by the body, are used to reduce the risk of breast cancer recurrence. Despite significantly lowering the risk of breast cancer recurrence in patients with estrogen-sensitive breast tumors, recent clinical research studies have shown that fewer than one-half of all breast cancer patients actually go on to complete the recommended 5-year course of hormonal therapy. (This very poor level of compliance with a medical therapy proven to lower recurrence and death rates associated with breast cancer is particularly an issue among younger women.)
While there are several reasons why more than half of all breast cancer patients do not complete their recommended course of hormonal therapy, one of the major causes, and especially among younger patients, is that these medications are commonly associated with significant side effects, including the same hot flashes that frequently accompany menopause.
Numerous treatment interventions have been tried in an effort prevent hot flashes associated with breast cancer therapy (as well as hot flashes in postmenopausal women without breast cancer), but very few of these therapies have been shown to have any clinically significant benefit. However, several previous clinical studies have suggested that certain types of antidepressant medications, as well as the blood pressure medication clonidine, may reduce the severity and frequency of hot flashes. Unfortunately, much of the research in this area has been of rather low quality, and so the findings of these lower level studies have not radically changed the way that most physicians have managed their patients' hot flashes. Now, a newly published prospective, randomized, placebo-controlled, blinded clinical research study, which appears in the current issue of the Journal of Clinical Oncology, strongly suggests that venlafaxine (also known by its trade name, Effexor®), a medication that is part of the new "serotonin–norepinephrine reuptake inhibitors" (SNRIs) class of antidepressants, and clonidine may both be effective in decreasing the severity and frequency of hot flashes in women with a history of breast cancer.
In this study, 102 women with a history of both breast cancer and severe hot flashes were secretly and randomly assigned to take either venlafaxine (75 mg per day), clonidine (0.1 mg per day), or an identical-appearing placebo (sugar) pill. Following 12 weeks of observation, 80 patients remained in this clinical study. At the end of this 12-week clinical study, both clonidine and venlafaxine were found to significantly decrease the severity and frequency of hot flashes, when compared to placebo pills. Although both medications were clinically effective in reducing hot flashes, and although venlafaxine resulted in a more rapid reduction in hot flashes than clonidine, clonidine was associated with a greater overall improvement in hot flashes, when compared to venlafaxine, after 12 weeks of treatment. (Venlafaxine was also associated with a greater incidence of nausea, constipation, and appetite loss, compared to clonidine.)
The findings of this study add to those of prior studies that have shown a 15 to 25% reduction in the severity and frequency of hot flashes with antidepressants such as venlafaxine, and with clonidine. Moreover, prior studies have shown that these two medications reduce the severity and frequency of hot flashes in women with a history of breast cancer as well as in postmenopausal women without a prior history of breast cancer.
One important limitation of this study is its small size, and its high patient drop-out rate, which resulted in small numbers of patient volunteers in each of the three "arms" of this prospective, randomized, blinded, placebo-controlled study. However, the findings of this small clinical research study, nonetheless, are still consistent with those of previously published studies; and taken together, these studies suggest that venlafaxine (and other modern antidepressant medications) and clonidine may be effective in reducing the severity and frequency of hot flashes in both breast cancer patients who are undergoing hormonal therapy for their cancer and in postmenopausal women with menopause-associated hot flashes.
For a comprehensive guide to living an evidence-based cancer prevention lifestyle, order your copy of my new book, A Cancer Prevention Guide for the Human Race. For the price of a cheeseburger, fries, and a shake, you can purchase this landmark new book, in both paperback and e-book formats, and begin living an evidence-based cancer prevention lifestyle today!
For a groundbreaking overview of cancer risks, and evidence-based strategies to reduce your risk of developing cancer, order your copy of my new book, "A Cancer Prevention Guide for the Human Race," from Amazon, Barnes & Noble, Books-A-Million,Vroman's Bookstore, and other fine bookstores!
On Thanksgiving Day, 2010, A Cancer Prevention Guide for the Human Race was ranked #6 among all cancer-related books on the Amazon.com "Top 100 Bestseller's List" for Kindle e-books! On Christmas Day, 2010, A Cancer Prevention Guide for the Human Race was the #1 book on the Amazon.com "Top 100 New Book Releases in Cancer" list!
Disclaimer: As always, my advice to readers is to seek the advice of your physician before making any significant changes in medications, diet, or level of physical activity
Dr. Wascher is an oncologic surgeon, professor of surgery, cancer researcher, oncology consultant, and a widely published author
For a different perspective on Dr. Wascher, please click on the following YouTube link:
I and the staff of Weekly Health Update would again like to take this opportunity to thank the more than 100,000 health-conscious people, from around the world, who visit this premier global health information website every month. (More than 1.2 million health-conscious people visited Weekly Health Update in 2010!) As always, we enjoy receiving your stimulating feedback and questions, and I will continue to try and personally answer as many of your inquiries as I possibly can.