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Timms Hill Climber's Log
highlandvillager - Jul 30, 2008 2:19 am Date Climbed: Jul 5, 2008Relaxing hike
Following the short hike to the highpoint, we enjoyed the view from the tower, then hiked past a Christmas tree farm to the "Prayer Cabin". From there, we hiked around "Swan Lake" before returning to the parking lot. HP13
Redwic - Jul 7, 2008 12:48 pm Date Climbed: Jul 4, 2008Nice Park and Highpoint
A nice, short woodland walk made this highpoint very enjoyable. I liked the summit towers. After taking several photos and getting repeatedly bit by mosquitoes, it was time to go.
This was the first of seven HPs attained on my most ambitious weekend HP road trip to date.
starship_jen - Jul 7, 2008 8:08 am Date Climbed: Jul 2, 2008HP #37
2nd of a 5 HP string road trip. Lovely day. Nice view from the tower.
Tbacon251 - Apr 7, 2008 10:22 am Date Climbed: Apr 5, 2008Snow!
Made the trip from Indiana with my daughter. Got to the park and vehicle traffic was prohibited due to the large amount of snow. We walked from the road to the observation tower (summit). Took several pictures including on of the USGS parker. We had a great trip. Tried Mt Avron in Michigan but there was too much snow to get close to the trail head.
jimegan - Feb 7, 2008 1:47 pm Date Climbed: Oct 18, 2007TIMMS HILL
wildfam - Jan 26, 2008 8:34 pm Date Climbed: Jan 3, 2008Snowshoe Hike
HP #11. Cold & sunny - perfect day for a snowshoe expedition (my first time on snowshoes). Plenty of snow. Base was right across the lake at Highpoint Village resort: stayed 2 nights (loved the Bear's Den cabin). Highpoint Village was a great place with wonderful hosts.
eric-griz - Nov 9, 2007 9:51 pm Date Climbed: Oct 12, 2002Cheese, Beer, Packers
Not successful on first attempt at Timm's Hill on account of our vehicle breaking down somewhere in Northern Wisconsin. Second time was a charm.
Holsti97 - Jul 29, 2007 6:43 am Date Climbed: Jul 28, 2007Top of the Badger State
Hiked about a mile to this HP from Highpoint Village with about 300 other HPers in conjunction with the Highpointers Konvention. Climbed the steel fire tower for a nice view of the area. Also climbed Pearson Hill, and Rib Mountain that day....the 2nd and 4th highest points in Wisconsin. We also climbed the two highpoints of Jackson County (Saddle Mound and a woods near Fairchild), the Clark County Highpoint (Dorchester hay field), and Taylor County Highpoint (old ski hill near Rib Lake) that week. HP #24.
The edge - Mar 14, 2007 3:14 pm Date Climbed: Jun 25, 2002HP #13
Lucky 13...
Nice tower...
My friend was too dizzy getting all the way up!!
The edge - Mar 14, 2007 3:13 pm Date Climbed: Jun 25, 2002HP #13
Lucky 13...
Nice tower...
My friend was too dizzy getting all the way up!!
weeds19 - Feb 27, 2007 6:35 pm Date Climbed: Sep 11, 2005Northern HP swing
I convinced my wife that while we were living in OH we "needed" to climb the HPs of WI, MN, and MI. This was the first of the three. There's a little taste of the desert SW here as well... we found "Hayduke Lives" carved into the wooden fire tower!
Aeldrin - Jan 20, 2007 9:33 pmWhee!
Performed a detour on the way to a convention with some friends to climb this peak. It was a lovely day to be out there, but we felt the trip was a little anti-climactic.
TLP - Aug 28, 2006 6:05 pm Date Climbed: Aug 25, 2006Problem with Timm's Hill
Okay I have a problem with Timm's Hill. I hate the place. Took a long drive down from Mt. Arvon the same day. The whole time the sky is getting darker. There was going to be a thunderstorm. Looks like I would make it in time till the road construction nonsense starts. Then the slow truck drivers. Still I make it into onto the road that leads to the park. And it's blocked off. It's going to rain any minute now. A guy tells me that he can't let me in, cause a track meet is going on now! I can hike up the road a little further down he says. I go down the road, and there's cars everywhere. It's like the damn Packers were playing there or something. He sends me up the wrong road, and I just about finally realize that while I'm walking when two damn dogs charge me! I had nothing on me either! I yell at them to go back, and amazingly they stop like 10 feet away from me. By this tme it is raining slightly. I go back to my car, figure the right way to go, and I hear thunder. I'm like f&^% this, and go to Tomahawk, WI to spend the night. The next morning I go back, and work my way around all the fallen trees on the road, and go to stupid Timm's Hill in a dense fog. I hope a forest fire burns the area. ...Well at least that is how I felt at the time.
royswkr - Aug 8, 2006 10:42 pm Date Climbed: May 31, 1989Short trail from county park
Also did short bushwhack to Pearson Hill, which has same elevation on map
Ilafan - Apr 14, 2006 2:55 amUgly Man-butt :(
I, for some reason, have done this one twice. The best part of this highpoint is the view of the trees, both on top of the tower and on the short hike from the parking lot. This, of course, is truest in the fall when I did it. HOWEVER, a "loving" couple decided to use the tower as their personal love nest the second time I went there, and because they were so, ahem, involved in what they were doing, they did not hear me climb the steps to the top. There is nothing that will ruin a highpoint more than an unexpected view of ugly, white, flabby man-ass. Must have been Packer fans.
Tie-Dye Mike - Apr 8, 2006 10:24 pm Date Climbed: Mar 15, 2006Closed road
The .8 mile long last road was closed, and had to snow shoe about 1 mile, (pretty flat mile, not strenous at all). Did this without a flashlight, but a full moon.
Drifter - Dec 29, 2005 9:20 pmDate Climbed: September 8, 2000
I climbed this and 3 other highpoints in a couple days. None of them significant, but they had to be done.
climbmn - Oct 11, 2005 3:28 pmRoute Climbed: Standard Date Climbed: September 5, 2005
Nice day to look at the trees from the stand.
Steve Gruhn - Aug 10, 2005 8:03 pmRoute Climbed: Standard Date Climbed: August 4, 2005
Climbed in the dark with a small light on my key chain. Had problems returning to the parking lot, so I wound up climbing it again twice in the wee hours of the following morning.
Climbed again on November 16, 2007, with Tami Tomski, this time in the daylight. A nice little walk.


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Subject: Agricultural Sciences Author Name: Hari D. Upadhyaya Keyword Term: Single nucleotide polymorphism
1 to 2 of 2 Results
Oct 25, 2016
Pavana J Hiremath; Ashish Kumar; R. Varma Penmetsa; Andrew D Farmer; Jessica A. Schlueter; Siva K. Chamarthi; Adam M. Whaley; Noelia Carrasquilla-Garcia; Pooran M.Gaur; Hari D. Upadhyaya; P. B. Kavi Kishor; Trushar M. Shah; Douglas R. Cook; Rajeev K. Varshney, 2016, "Chickpea genetic map comprising 1328 marker loci", https://doi.org/10.21421/D2/YC6QWG, ICRISAT Dataverse, V1A second-generation genetic map comprising 1328 marker loci including novel 625 CKAMs, 314 TOG-SNPs and 389 published marker loci with an average inter-marker distance of 0.59 cM. CMap Visualization Links: 1328 loci map DOI: doi:10.1111/j.1467-7652.2012.00710.x
Oct 25, 2016
Neha Gujaria; Ashish Kumar; Preeti Dauthal; Anuja Dubey; Pavana J Hiremath; BhanuPrakash Amindala; Andrew D Farmer; Mangla Bhide; Trushar Shah; Pooran M.Gaur; Hari D. Upadhyaya; Sabhyata Bhatia; Douglas R. Cook; Gregory D May; Rajeev K. Varshney, 2016, "Transcript map of Chickpea (Cicer arietinum L.)", https://doi.org/10.21421/D2/TOYQD2, ICRISAT Dataverse, V1A transcript map has been constructed by the development and integration of genic molecular markers (GMMs) including single nucleotide polymorphism (SNP), genic microsatellite or simple sequence repeat (SSR) and intron spanning region (ISR)-based markers, on an inter-specific map...
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subset: commoncrawl


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The PHP development group has officially released the latest bugfix release in the PHP 5.3.x series - PHP 5.3.27:
The PHP development team announces the immediate availability of PHP 5.3.27. About 10 bugs were fixed, including a security fix in the XML parser (Bug #65236). Please Note: This will be the last regular release of the PHP 5.3 series. All users of PHP are encouraged to upgrade to PHP 5.4 or PHP 5.5. The PHP 5.3 series will receive only security fixes for the next year.
You can get this latest release from the downloads page (or here for Windows users). As the update fixes a security issue, it's recommended that you upgrade (see this bug).


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COVER STORY: Two Melbourne academics want infanticide legalised
QUEENSLAND: Election outcome could derail same-sex marriage push
MEDIA: Journalists scandalised by family lobby's tactics
CANBERRA OBSERVED: Abbott's pre-election commitments come under scrutiny
EDITORIAL: Bob Carr's appointment will destabilise Labor
MEDIA INQUIRY: Finkelstein's Monster: a media horror story
POLITICS: Is GetUp! a democratic organisation?
POLITICS: Daniel Hannan: future prime minister of Britain?
IRAN: Iranian opposition pleas unheeded by Obama
INTERNATIONAL TRADE: The case against floating exchange rates
PARENTING: Caring for terminally-ill unborn babies
SCHOOLS: Gonski report penalises non-government schools
OPINION: Russia and the West reverse roles on Christianity
CINEMA: Marilyn's mystique mesmerises still: My Week with Marilyn (rated M)
BOOK REVIEW From Vinegar Hill to the mountains of Afghanistan
BOOK REVIEW Excommunicable heresies
by Bill Muehlenberg
News Weekly, March 17, 2012
Two Melbourne-based ethicists have recently called for the legalisation of infanticide.
Dr Alberto Giubilini, of Melbourne's Monash University, and Dr Francesca Minerva at the University of Melbourne's Centre for Applied Philosophy and Public Ethics, have asserted, in the latest edition of the Journal of Medical Ethics (February 23, 2012), that the newborn are not persons.
They argue that if the abortion of the unborn is allowable, so too should be the termination — that is, the killing — of the newborn.
They state that "when circumstances occur after birth such that they would have justified abortion, what we call after-birth abortion should be permissible" (Italics are the authors').
An introductory abstract of the article summarises the two authors' arguments as follows:
"Abortion is largely accepted even for reasons that do not have anything to do with the foetus's health. By showing that (1) both foetuses and newborns do not have the same moral status as actual persons, (2) the fact that both are potential persons is morally irrelevant and (3) adoption is not always in the best interest of actual people, the authors argue that what we call 'after-birth abortion' (killing a newborn) should be permissible in all the cases where abortion is, including cases where the newborn is not disabled."
When academics such as these call for baby-killing, you know we have reached the outer limits of the moral atmosphere. Our mighty intellectuals, who are supposed to be training the next generation, both mentally and morally, are often instead doing society a great disservice.
To be well educated is certainly no guarantee of general intelligence or wisdom. To have a string of letters after one's name is obviously not a sign of high moral acumen. Tragically, we often have some of the most morally deficient and intellectually lacklustre positions being argued for by our academics.
Not that Drs Giubilini and Minerva are the first Australian academics to make a case for infanticide.
Another well-known academic of this persuasion, who commenced his career many years ago at Monash University, is Peter Singer. He is now a professor at Princeton University in the United States.
He is a long-standing advocate not only of abortion and euthanasia, but of infanticide as well. He believes that the new-born must not automatically be considered to be persons, and they must be tested to see who should live and who should die. (See a profile I wrote, "Peter Singer and the gospel of death", CultureWatch, October 14, 1996).
Giubilini and Minerva state the following in their defence of infanticide: "Merely being human is not in itself a reason for ascribing someone a right to life. Indeed, many humans are not considered subjects of a right to life: spare embryos where research on embryo stem cells is permitted, foetuses where abortion is permitted, criminals where capital punishment is legal."
However, anyone exercising some intellectual and moral clarity would see just how slippery such weasel words are. The authors do not establish what they are seeking to argue for — namely, the non-personhood of certain humans — they simply assert it. That does not constitute an argument.
The case for the non-personhood of these classes of humans has not been made. They simply take a backward step in ethical reasoning: proceeding from what is to what ought to be. They assume description should lead to prescription. They think that if we are already killing some human beings, then it must be morally acceptable.
Of course they have things back to front here. We first should be examining the moral and ontological status of these groups. We should determine if they are in fact persons. And if they are, then of course killing them is quite wrong.
The fact that embryos are now being destroyed does not mean it is morally licit. That which is legal is not always moral. As can be seen in the blue panel on the left, it was quite legal in Nazi Germany to kill all sorts of classes of human beings. But that legality did not mean it was therefore morally right.
The same is true of the unborn child. Simply declaring that such a human is a non-person is not based on science: it is a philosophical pre-commitment. In Singer's case it is utilitarianism and pragmatism. He has simply assumed, ahead of time, that certain groups are non-persons, and can therefore be bumped off at will.
And the two Melbourne academics also have great misunderstandings about the nature of capital punishment. No one argues that those warranting the death penalty have somehow become non-persons. It is exactly because they are persons, and have committed heinous crimes against other persons (such as murder), that the state takes these issues so seriously.
So we have three cases appealed to by these ethicists, and not one of them stands up under scrutiny. We have the same old story of some intellectuals and academics telling us that certain people are not persons, and therefore must forfeit the right to life.
They have merely made a pronouncement based on their secular utilitarian worldview. They have not established their case, and they have not proved in any sense of the term that the unborn and others are in fact non-persons. But by their lending of more intellectual and professional credibility to the case for baby-killing, they make it seem all the more acceptable, and will undoubtedly sway the views of many.
This is a grave abuse of medical ethics and the academic community. Using the classroom and scholarly journals to make the case — coolly and calmly — for baby-killing is not an indication of professionalism and progress. It is a sign of barbarism and regress. And we have seen it happen all before.
Have we not yet learned the lessons of history? Apparently not.
A genuinely ethical person would be utterly thunderstruck and outraged by what these ethicists are saying. Those who shrug and show no concern about all this, and offer no vocal opposition, are scarcely any better than these ethicists.
Tragically, there was mainly silence from the German citizens living during the reign of Hitler's Nazis. I passionately hope there will not be this deadly silence again today, when similar pro-death ideologies are being allowed full sway in the public arena. Those who cannot or will not get incensed by the explicit call for the legalisation of infanticide are moral zombies who have long ago lost both head and heart.
Someone who understood the peril of compromising with evil, and who paid for his moral stand with his life, was the German pastor Dietrich Bonhoeffer. He warned: "Silence in the face of evil is itself evil: God will not hold us guiltless. Not to speak is to speak. Not to act is to act."
Or, as we read in Dante's Inferno, "The hottest places in hell are reserved for those who, in times of great moral crisis, maintain their neutrality."
Bill Muehlenberg is a commentator on contemporary issues, and lectures on ethics and philosophy. His website CultureWatch is at: www.billmuehlenberg.com
Bill Muehlenberg, "Peter Singer and the gospel of death", CultureWatch, October 14, 1996. URL: www.billmuehlenberg.com/1996/10/14/peter-singer-and-the-gospel-of-death/
Bill Muehlenberg, "Those unethical ethicists", CultureWatch, November 18, 1996. URL: www.billmuehlenberg.com/2008/11/18/those-unethical-ethicists/
Alberto Giubilini and Francesca Minerva, "After-birth abortion: why should the baby live?", Journal of Medical Ethics, February 23, 2012. URL: http://jme.bmj.com/content/early/2012/03/01/medethics-2011-100411.full
Liz Klimas, "Ethicists argue in favor of 'after-birth abortions' as newborns 'are not persons'", The Blaze (United States), February 27, 2012. URL: www.theblaze.com/stories/ethicists-argue-in-favor-of-after-birth-abortions-as-newborns-are-not-persons/
John Jalsevac, "Journal editor defends pro-infanticide piece: Killing newborns is already legal in Holland", LifeSiteNews.com, February 28, 2012. URL: www.lifesitenews.com/news/journal-editor-defends-pro-infanticide-piece-killing-newborns-is-already-le?utm_source=LifeSiteNews.com+Daily+Newsletter&utm_campaign=67f1dd4545-LifeSiteNews_com_Intl_Headlines_02_28_2012&utm_medium=email
Milestones to Hitler's Final Solution
A major element leading up to the "Final Solution" in Germany was the notion that some people — indeed, whole classes of people — were not persons.
Decades before the Holocaust there were many academic positions and pronouncements which prepared the way for what Hitler and the Nazis did. In 1895 the German legal scholar Alfred Jost wrote an influential volume, The Right to Die, and in 1904 the German Society for Racial Hygiene was formed.
Of special importance was the publication in 1920 of Alfred Hoche and Karl Binding's Die Freigabe der Vernichtung Lebensunwerten Lebens (The Authorisation of the Destruction of Life Unworthy of Life). This volume promoted the concept of "lives not worth living". It spoke of the "incurable feebleminded" who should be killed. It all led nicely to Hitler's political manifesto, Mein Kampf (1925-1926).
State-sponsored euthanasia was called for, with the idea that many humans had to be excluded from those deserving the right to life. Other writings appeared, with much discussion, especially in the German medical community. All this helped pave the way for the programs the Nazis enacted after they came to power in 1933.
As Henry Friedlander says in the opening of his important book, The Origins of Nazi Genocide: From Euthanasia to the Final Solution (1995), "Nazi genocide did not take place in a vacuum. Genocide was only the most radical method of excluding groups of human beings from the German national community. The policy of exclusion followed and drew upon more than fifty years of scientific opposition to the equality of man."
Extract from Bill Muehlenberg, "Infanticide again", CultureWatch, February 28, 2012. URL: www.billmuehlenberg.com/2012/02/28/infanticide-again/
Critics of infanticide accused of "hate speech"
The editor of an ethics journal that recently published an article advocating infanticide (what the authors call "post-birth abortion"), has responded to widespread criticism by pointing out that promoting the killing of newborns is nothing new: in fact, in the Netherlands infant euthanasia is already legal and practised.
Editor Julian Savulescu also criticises what he calls the "hate speech" directed at the authors of the article, arguing that the public's response to the piece shows that "proper academic discussion and freedom are under threat from fanatics opposed to the very values of a liberal society".
In the journal article Alberto Giubilin, a philosopher from the University of Milan, and Francesca Minerva, an ethicist from the University of Melbourne, made the case that "after-birth abortion" should be permissible in all the cases where abortion is, including cases where the newborn is perfectly healthy. They base their argument on the premise that the unborn baby and the newborn do not have the moral status of actual persons and are consequently "morally irrelevant".
In response to the backlash, Savulescu wrote that the arguments in the article "are largely not new and have been presented repeatedly in the academic literature and public forums by the most eminent philosophers and bioethicists in the world, including Peter Singer, Michael Tooley and John Harris".
He also observes that the paper "draws attention to the fact that infanticide is practised in the Netherlands".
Extract from John Jalsevac, "Journal editor defends pro-infanticide piece: Killing newborns is already legal in Holland", LifeSiteNews.com, February 28, 2012. URL: www.lifesitenews.com/news/journal-editor-defends-pro-infanticide-piece-killing-newborns-is-already-le?utm_source=LifeSiteNews.com+Daily+Newsletter&utm_campaign=67f1dd4545-LifeSiteNews_com_Intl_Headlines_02_28_2012&utm_medium=email
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Hewitt's only waiting on you for the Rumble game.
there you go.
When you reply to someone in a VM, you post your VM on their profile, so they get notified when you reply to them. If you post on your own profile, nobody will get notified except maybe you.
I'm staying I used to play stick empires but that has died down now. So yes I'm looking forward to posting on general and enjoying the many members their so as yourself. Thank you for messaging me.
I see you've decided to come into the General Section. Are you staying or just coming by?
Senior Member


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People with diabetes mellitus have increased infection risk. With diabetes, urinary tract infection (UTI) is more common and has worse outcomes. Here, we investigate how diabetes and insulin resistance impact the kidney's innate defenses and urine sterility. We report that type 2 diabetic mice have increased UTI risk. Moreover, insulin-resistant prediabetic mice have increased UTI susceptibility, independent of hyperglycemia or glucosuria. To identify how insulin resistance affects renal antimicrobial defenses, we genetically deleted the insulin receptor in the kidney's collecting tubules and intercalated cells. Intercalated cells, located within collecting tubules, contribute to epithelial defenses by acidifying the urine and secreting antimicrobial peptides (AMPs) into the urinary stream. Collecting duct and intercalated cell–specific insulin receptor deletion did not impact urine acidification, suppressed downstream insulin-mediated targets and AMP expression, and increased UTI susceptibility. Specifically, insulin receptor–mediated signaling regulates AMPs, including lipocalin 2 and ribonuclease 4, via phosphatidylinositol-3-kinase signaling. These data suggest that insulin signaling plays a critical role in renal antibacterial defenses.
Matthew J. Murtha, Tad Eichler, Kristin Bender, Jackie Metheny, Birong Li, Andrew L. Schwaderer, Claudia Mosquera, Cindy James, Laura Schwartz, Brian Becknell, John David Spencer
The pathogenesis of ischemic diseases remains unclear. Here we demonstrate the induction of microRNA-668 (mir-668) in ischemic acute kidney injury (AKI) in human patients, mice, and renal tubular cells. The induction was HIF-1dependant as HIF-1-deficiency in cells and kidney proximal tubules attenuated mir-668 expression. We further identified a functional HIF-1 binding site in mir-668 gene promoter. Anti-mir-668 increased apoptosis in renal tubular cells and enhanced ischemic AKI in mice, whereas mir-668 mimic was protective. Mechanistically, anti-mir-668 induced mitochondrial fragmentation, whereas mir-668 blocked mitochondrial fragmentation during hypoxia. We analyzed mir-668 target genes through immunoprecipitation of microRNA-induced silencing complexes followed by RNA deep sequencing and identified 124 protein-coding genes as likely targets of mir-668. Among these genes, only Mitochondrial Protein 18 KDa (MTP18) has been implicated in mitochondrial dynamics. In renal cells and mouse kidneys, mir-668 mimic suppressed MTP18, whereas anti-mir-668 increased MTP18 expression. Luciferase microRNA target reporter assay further verified MTP18 as a direct target of mir-668. In renal tubular cells, knockdown of MTP18 suppressed mitochondrial fragmentation and apoptosis. Together, the results suggest that mir-668 is induced via HIF-1 in ischemic AKI and, upon induction, mir-668 represses MTP18 to preserve mitochondrial dynamics for renal tubular cell survival and kidney protection.
Qingqing Wei, Haipeng Sun, Shuwei Song, Yong Liu, Pengyuan Liu, Man J. Livingston, Jianwen Wang, Mingyu Liang, Qing-Sheng Mi, Yuqing Huo, N. Stanley Nahman, Changlin Mei, Zheng Dong
Steroid-resistant nephrotic syndrome (SRNS) almost invariably progresses to end-stage renal disease. Although more than 50 monogenic causes of SRNS have been described, a large proportion of SRNS remains unexplained. Recently, it was discovered that mutations of NUP93 and NUP205, encoding 2 proteins of the inner ring subunit of the nuclear pore complex (NPC), cause SRNS. Here, we describe mutations in genes encoding 4 components of the outer rings of the NPC, namely NUP107, NUP85, NUP133, and NUP160, in 13 families with SRNS. Using coimmunoprecipitation experiments, we showed that certain pathogenic alleles weakened the interaction between neighboring NPC subunits. We demonstrated that morpholino knockdown of nup107, nup85, or nup133 in Xenopus disrupted glomerulogenesis. Re-expression of WT mRNA, but not of mRNA reflecting mutations from SRNS patients, mitigated this phenotype. We furthermore found that CRISPR/Cas9 knockout of NUP107, NUP85, or NUP133 in podocytes activated Cdc42, an important effector of SRNS pathogenesis. CRISPR/Cas9 knockout of nup107 or nup85 in zebrafish caused developmental anomalies and early lethality. In contrast, an in-frame mutation of nup107 did not affect survival, thus mimicking the allelic effects seen in humans. In conclusion, we discovered here that mutations in 4 genes encoding components of the outer ring subunits of the NPC cause SRNS and thereby provide further evidence that specific hypomorphic mutations in these essential genes cause a distinct, organ-specific phenotype.
Daniela A. Braun, Svjetlana Lovric, David Schapiro, Ronen Schneider, Jonathan Marquez, Maria Asif, Muhammad Sajid Hussain, Ankana Daga, Eugen Widmeier, Jia Rao, Shazia Ashraf, Weizhen Tan, C. Patrick Lusk, Amy Kolb, Tilman Jobst-Schwan, Johanna Magdalena Schmidt, Charlotte A. Hoogstraten, Kaitlyn Eddy, Thomas M. Kitzler, Shirlee Shril, Abubakar Moawia, Kathrin Schrage, Arwa Ishaq A. Khayyat, Jennifer A. Lawson, Heon Yung Gee, Jillian K. Warejko, Tobias Hermle, Amar J. Majmundar, Hannah Hugo, Birgit Budde, Susanne Motameny, Janine Altmüller, Angelika Anna Noegel, Hanan M. Fathy, Daniel P. Gale, Syeda Seema Waseem, Ayaz Khan, Larissa Kerecuk, Seema Hashmi, Nilufar Mohebbi, Robert Ettenger, Erkin Serdaroğlu, Khalid A. Alhasan, Mais Hashem, Sara Goncalves, Gema Ariceta, Mercedes Ubetagoyena, Wolfram Antonin, Shahid Mahmood Baig, Fowzan S. Alkuraya, Qian Shen, Hong Xu, Corinne Antignac, Richard P. Lifton, Shrikant Mane, Peter Nürnberg, Mustafa K. Khokha, Friedhelm Hildebrandt
Renin cells are crucial for survival: they control fluid-electrolyte and blood pressure homeostasis, vascular development, regeneration, and oxygen delivery to tissues. During embryonic development, renin cells are progenitors for multiple cell types which retain the memory of the renin phenotype. When there is a threat to survival, those descendants are transformed and reenact the renin phenotype to restore homeostasis. We tested the hypothesis that the molecular memory of the renin phenotype resides in unique regions and states of these cells' chromatin. Using renin cells at various stages of stimulation, we identified regions in the genome where the chromatin is open for transcription, mapped histone modifications characteristic of active enhancers such as H3K27ac and deposition of transcriptional activators such a Med1 whose deletion results in ablation of Renin expression and low blood pressure. Using the rank ordering of super-enhancers, epigenetic re-writing, and enhancer deletion analysis, we found that renin cells harbor a unique set of super-enhancers that determine their identity. The most prominent Renin super-enhancer may act as a chromatin sensor of signals that convey the physiologic status of the organism and is responsible for the transformation of renin cell descendants to the renin phenotype, a fundamental process to ensure homeostasis.
Maria Florencia Martinez, Silvia Medrano, Evan A. Brown, Turan Tufan, Stephen Shang, Nadia Bertoncello, Omar Guessoum, Mazhar Adli, Brian C. Belyea, Maria Luisa S. Sequeira Lopez, R. Ariel Gomez
Oxidative stress is an underlying component of acute and chronic kidney disease. Apoptosis signal-regulating kinase 1 (ASK1) is a widely expressed redox-sensitive serine threonine kinase that activates p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase kinases, and induces apoptotic, inflammatory, and fibrotic signaling in settings of oxidative stress. Herein, we describe the discovery and characterization of a potent and selective small molecule inhibitor of ASK1, GS-444217, and demonstrate the therapeutic potential of ASK1 inhibition to reduce kidney injury and fibrosis. Activation of the ASK1 pathway in glomerular and tubular compartments was confirmed in renal biopsies from patients with diabetic kidney disease (DKD) and was decreased by GS-444217 in several rodent models of kidney injury and fibrosis that collectively represented the hallmarks of DKD pathology. Treatment with GS-444217 reduced progressive inflammation and fibrosis in the kidney and halted decline of glomerular filtration rate. Combination of GS-444217 with enalapril, an angiotensin-converting enzyme inhibitor, led to a greater reduction in proteinuria and regression of glomerulosclerosis. These results identify ASK1 as an important target for renal disease and support the clinical development of an ASK1 inhibitor for the treatment of diabetic kidney disease.
John T. Liles, Britton K. Corkey, Gregory T. Notte, Grant Budas, Eric B. Lansdon, Ford Hinojosa-Kirschenbaum, Shawn S. Badal, Michael Lee, Brian E. Schultz, Sarah Wise, Swetha Pendem, Michael Graupe, Laurie Castonguay, Keith A. Koch, Melanie H. Wong, Giuseppe A. Papalia, Dorothy M. French, Theodore Sullivan, Erik G. Huntzicker, Frank Y. Ma, David J. Nikolic-Paterson, Tareq Altuhaifi, Haichun Yang, Agnes B. Fogo, David G. Breckenridge
Podocyte malfunction occurs in autoimmune and nonautoimmune kidney disease. Calcium signaling is essential for podocyte injury, but the role of Ca2+/calmodulin–dependent kinase (CaMK) signaling in podocytes has not been fully explored. We report that podocytes from patients with lupus nephritis and focal segmental glomerulosclerosis and lupus-prone and lipopolysaccharide- or adriamycin-treated mice display increased expression of CaMK IV (CaMK4), but not CaMK2. Mechanistically, CaMK4 modulated podocyte motility by altering the expression of the GTPases Rac1 and RhoA and suppressed the expression of nephrin, synaptopodin, and actin fibers in podocytes. In addition, it phosphorylated the scaffold protein 14-3-3β, which resulted in the release and degradation of synaptopodin. Targeted delivery of a CaMK4 inhibitor to podocytes preserved their ultrastructure, averted immune complex deposition and crescent formation, and suppressed proteinuria in lupus-prone mice and proteinuria in mice exposed to lipopolysaccharide-induced podocyte injury by preserving nephrin/synaptopodin expression. In animals exposed to adriamycin, podocyte-specific delivery of a CaMK4 inhibitor prevented and reversed podocyte injury and renal disease. We conclude that CaMK4 is pivotal in immune and nonimmune podocyte injury and that its targeted cell-specific inhibition preserves podocyte structure and function and should have therapeutic value in lupus nephritis and podocytopathies, including focal segmental glomerulosclerosis.
Kayaho Maeda, Kotaro Otomo, Nobuya Yoshida, Mones S. Abu-Asab, Kunihiro Ichinose, Tomoya Nishino, Michihito Kono, Andrew Ferretti, Rhea Bhargava, Shoichi Maruyama, Sean Bickerton, Tarek M. Fahmy, Maria G. Tsokos, George C. Tsokos
T cells play a key role in immune-mediated glomerulonephritis, but how cytotoxic T cells interact with podocytes remains unclear. To address this, we injected EGFP-specific CD8+ T cells from just EGFP death inducing (Jedi) mice into transgenic mice with podocyte-specific expression of EGFP. In healthy mice, Jedi T cells could not access EGFP+ podocytes. Conversely, when we induced nephrotoxic serum nephritis (NTSN) and injected Jedi T cells, EGFP+ podocyte transgenic mice showed enhanced proteinuria and higher blood urea levels. Morphometric analysis showed greater loss of EGFP+ podocytes, which was associated with severe crescentic and necrotizing glomerulonephritis. Notably, only glomeruli with disrupted Bowman's capsule displayed massive CD8+ T cell infiltrates that were in direct contact with EGFP+ podocytes, causing their apoptosis. Thus, under control conditions with intact Bowman's capsule, podocytes are not accessible to CD8+ T cells. However, breaches in Bowman's capsule, as also noted in human crescentic glomerulonephritis, allow access of CD8+ T cells to the glomerular tuft and podocytes, resulting in their destruction. Through these mechanisms, a potentially reversible glomerulonephritis undergoes an augmentation process to a rapidly progressive glomerulonephritis, leading to end-stage kidney disease. Translating these mechanistic insights to human crescentic nephritis should direct future therapeutic interventions at blocking CD8+ T cells, especially in progressive stages of rapidly progressive glomerulonephritis.
Anqun Chen, Kyung Lee, Vivette D. D'Agati, Chengguo Wei, Jia Fu, Tian-Jun Guan, John Cijiang He, Detlef Schlondorff, Judith Agudo
Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying pathogenesis is poorly understood. Nod-like receptor pyrin containing 3–deficient (Nlrp3-deficient) mice displayed reduced epithelial cell injury and inflammation in the kidney in a model of contrast-induced AKI (CI-AKI). Unexpectedly, contrast agents directly induced tubular epithelial cell death in vitro that was not dependent on Nlrp3. Rather, contrast agents activated the canonical Nlrp3 inflammasome in macrophages. Intravital microscopy revealed diatrizoate (DTA) uptake within minutes in perivascular CX3CR1+ resident phagocytes in the kidney. Following rapid filtration into the tubular luminal space, DTA was reabsorbed and concentrated in tubular epithelial cells via the brush border enzyme dipeptidase-1 in volume-depleted but not euvolemic mice. LysM-GFP+ macrophages recruited to the kidney interstitial space ingested contrast material transported from the urine via direct interactions with tubules. CI-AKI was dependent on resident renal phagocytes, IL-1, leukocyte recruitment, and dipeptidase-1. Levels of the inflammasome-related urinary biomarkers IL-18 and caspase-1 were increased immediately following contrast administration in patients undergoing coronary angiography, consistent with the acute renal effects observed in mice. Taken together, these data show that CI-AKI is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.
Arthur Lau, Hyunjae Chung, Takanori Komada, Jaye M. Platnich, Christina F. Sandall, Saurav Roy Choudhury, Justin Chun, Victor Naumenko, Bas G.J. Surewaard, Michelle C. Nelson, Annegret Ulke-Lemée, Paul L. Beck, Hallgrimur Benediktsson, Anthony M. Jevnikar, Sarah L. Snelgrove, Michael J. Hickey, Donna L. Senger, Matthew T. James, Justin A. Macdonald, Paul Kubes, Craig N. Jenne, Daniel A. Muruve
Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is still an unmet biomedical challenge, because once chronic lesions have manifested, no effective therapies are available as of yet for clinical use. Prompted by various studies across multiple organs demonstrating that preconditioning regimens to induce endogenous regenerative mechanisms protect various organs from later incurring acute injuries, we here aimed to gain insights into the molecular mechanisms underlying successful protection and to explore whether such pathways could be utilized to inhibit progression of chronic organ injury. We identified a protective mechanism that is controlled by the transcription factor ARNT, which effectively inhibits progression of chronic kidney injury by transcriptional induction of ALK3, the principal mediator of anti-fibrotic and pro-regenerative BMP signaling responses. We further report that ARNT expression itself is controlled by the FKBP12/YY1 transcriptional repressor complex, and that disruption of such FKBP12/YY1 complexes by picomolar FK506 at sub-immunosuppressive doses increases ARNT expression, subsequently leading to homodimeric ARNT-induced ALK3 transcription. Direct targeting of FKBP12/YY1 with in vivo-morpholino approaches or small molecule inhibitors including GPI-1046 were equally effective to induce ARNT expression with subsequent activation of ALK3-dependent canonical BMP signaling responses and attenuated chronic organ failure in models of chronic kidney, but also cardiac and liver injuries. In summary, we report an organ protective mechanism, which can be pharmacologically modulated by immunophilin ligands FK506, GPI-1046 or therapeutically targeted by in vivo-morpholino approaches.
Björn Tampe, Désirée Tampe, Gunsmaa Nyamsuren, Friederike Klöpper, Gregor Rapp, Anne Kauffels, Thomas Lorf, Elisabeth M. Zeisberg, Gerhard A. Müller, Raghu Kalluri, Samy Hakroush, Michael Zeisberg
Histone protein modifications control fate determination during normal development and dedifferentiation during disease. Here, we set out to determine the extent to which dynamic changes to histones affect the differentiated phenotype of ordinarily quiescent adult glomerular podocytes. To do this, we examined the consequences of shifting the balance of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark in podocytes. Adriamycin nephrotoxicity and subtotal nephrectomy (SNx) studies indicated that deletion of the histone methylating enzyme EZH2 from podocytes decreased H3K27me3 levels and sensitized mice to glomerular disease. H3K27me3 was enriched at the promoter region of the Notch ligand Jag1 in podocytes, and derepression of Jag1 by EZH2 inhibition or knockdown facilitated podocyte dedifferentiation. Conversely, inhibition of the Jumonji C domain–containing demethylases Jmjd3 and UTX increased the H3K27me3 content of podocytes and attenuated glomerular disease in adriamycin nephrotoxicity, SNx, and diabetes. Podocytes in glomeruli from humans with focal segmental glomerulosclerosis or diabetic nephropathy exhibited diminished H3K27me3 and heightened UTX content. Analogous to human disease, inhibition of Jmjd3 and UTX abated nephropathy progression in mice with established glomerular injury and reduced H3K27me3 levels. Together, these findings indicate that ostensibly stable chromatin modifications can be dynamically regulated in quiescent cells and that epigenetic reprogramming can improve outcomes in glomerular disease by repressing the reactivation of developmental pathways.
Syamantak Majumder, Karina Thieme, Sri N. Batchu, Tamadher A. Alghamdi, Bridgit B. Bowskill, M. Golam Kabir, Youan Liu, Suzanne L. Advani, Kathryn E. White, Laurette Geldenhuys, Karthik K. Tennankore, Penelope Poyah, Ferhan S. Siddiqi, Andrew Advani


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Rowand Set to Return
"I'm not much of a climber, more of a bulldozer," said Aaron Rowand when he met the Philadelphia media last November following the trade with the White Sox.
Making a catch, running into a metal fence, breaking your nose and other facial bones and getting stitches I suppose can be called the work of a bulldozer.
On Friday afternoon, he and Mike Lieberthal will hit in a simulated game at Citizens Bank Park. Barring a setback, Rowand will be back in the lineup for the first time since May 11 on Saturday night at Citizens Bank Park. Lieby may also be activated this weekend.
While on the DL, Rowand met with the media and did numerous radio and TV shows. He became a folk hero. His response to a media conference question about sacrificing his body for a catch got huge play: "For who? My teammates. For what? To win."
If merchandise sales are any indication, it will be buzzing on Saturday night. The Phillies were home last weekend for the first time since "The Catch" for three games with the Red Sox. Through the first 24 games of the season, Rowand's name and number t-shirts sold on average 12 per game.
Last weekend, sales averaged 76 per game, an increase of over 500%.
Shane Victorino has certainly done an outstanding job filling in for Rowand. Shane gives the Phillies four quality outfielders. Getting Aaron and Lieby back will be a big boost.
What kind of reception will Rowand receive?
2 Comments
Sox, of the Chicago kind, just wants to welcome Aaron back. My daughter and I have been watching for his return and even though we don't catch many Phils games, we do looks for highlights of them to see if we can find Aaron. Hope you guys enjoy him as much as we did/do. She still wears her Rowand tee shirt purchased just last year!
So glad to see him back – he's so important to the team. He is a born outfielder. Just watching him judge fly balls is fun.


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What Is Fifth Disease?
Fifth disease, or erythema infectiosum, is a mildly to moderately contagious viral infection common among school-age children, particularly in the winter and spring.
Though it can resemble other childhood rashes, such as rubella or scarlet fever, fifth disease usually begins with the distinctive, sudden appearance of bright red cheeks that look as though the child has been slapped. The disease is rare in infants and adults.
Fifth disease got its name many years ago when it was the fifth on a list of the six recognized childhood rash-forming illnesses; the others include rubella, measles, scarlet fever, chickenpox, and roseola infantum. It also is called slapped-cheek disease because of the characteristic initial appearance in children.
Fifth disease is usually mild. It is spread by respiratory droplets that enter the air when an infected person coughs or sneezes, or through blood. It poses little risk to healthy children and adults, with a couple of exceptions: pregnant women and people with certain types of chronic anemia. If a pregnant woman is infected in the first half of her pregnancy, there is a small risk of severe anemia in the fetus and a 10% risk of miscarriage.
What Causes Fifth Disease?
Fifth disease is caused by parvovirus B19 and is spread by respiratory secretions from an infected person. By the time the rash appears, children are no longer contagious and may attend school or day care. The incubation period (the period between infection and signs or symptoms of illness) is usually four to 14 days, but can be as long as 21 days.
Adults who work with young children -- such as child-care providers, teachers, and those in health care fields -- are most likely to be exposed.


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"Genius is the ability to renew one's emotions in daily experience," said French painter Paul Cezanne. What do you think he meant by that? Here's one interpretation: Many of us replay the same old emotions over and over again — even in response to experiences that are nothing like the past events when we felt those exact feelings. So a genius might be someone who generates a fresh emotion for each new adventure. Here's another possible interpretation of Cezanne's remark: It can be hard to get excited about continually repeating the basic tasks of our regular routines day after day. But a genius might be someone who is good at doing just that. I think that by both of these definitions, 2013 could be a genius year for you Aquarians.
Related articles
- Cézanne: A Life by Alex Danchev: review (telegraph.co.uk)
- Genius vs. Talent (danpink.com)
- Elizabeth Gilbert: Your elusive creative genius (popalx.wordpress.com)


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More and more Republicans are saying they will violate Grover Norquist's anti-tax pledge, and it's about time, I write in my latest column for CNN:
"This post-election outbreak of pragmatism is welcome and needed. These senators and congressmen are profiles in courage for speaking out against the stranglehold that one self-appointed activist and lobbyist has had on bipartisan governing."
Norquist, a conservative activist and leader of Americans for Tax Reform, has long had a stranglehold on legislators in the GOP who might otherwise be willing to compromise on ways to increase revenue. Now, with the fiscal cliff looming, it looks as though the party might be able to break his grip. That could go a long way toward breaking partisan gridlock:
"The biggest stumbling block for tea party conservatives has been Norquist, who says any new revenue violates the pledge and promises to invite a primary challenge to any member of Congress who puts revenues on the table. Given the number of safe seats carved up in the rigged system of redistricting, a primary challenge from the wings is what most members of Congress fear most. The result is gridlock: an inability to reason together and make a long-term deal for the good of the country.
"It is an ironic problem in some ways: Tea party congressmen rose to power on a promise to deal with deficits and debt. Putting anti-tax absolutism ahead of that goal may play well with special interests, but it undercuts the ability to govern in the national interest. That's what is at stake."
Read the rest at CNN.


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09 November, 2017
Syllable ChaseDoes anyone else remember a Bono inviting a guy on stage to play guitar, and the guy giving Bono a tape? Bono asked him the name of his band and the guy said "Syllable Chase."
26 November, 2012
DALTON BROSbodeans--pretenders-dalton bros. what a show 'whats with all the balloons"? 12th row. snuck my lil bro up from the nose bleeds. to bad they booed the dalton's. the other 90,000 couldn't see. that's L.A. for you.
10 May, 2010
first U2 showI was 15 years old and was lucky enough to be invited by older H.S. friends who had an extra ticket to this amazing show. I have not missed a tour since. Thank you for all the memories and wonderful music!
16 April, 2010
First U2 ConcertLets see if years of smoking weed screwd my memory: Steve Jones and the Pretenders were the warm up bands. Rainy... But it stoped right after the Pretenders set... I remeber the Pretenders song dont get me wrong , When Krissy Hines said who can explain the thunder and rain. Sudently it started comming down.... It was really a moment I will not forget. I drove my old 69 Toyota Corona.... I miss that peice of shit car....


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Basic Linear Algebra Subprograms (BLAS)," (an update), submitted to ACM TOMS, February 2001. (228.33 KB)"
Batched BLAS (Basic Linear Algebra Subprograms) 2018 Specification , July 2018. (483.05 KB)
An Updated Set of Basic Linear Algebra Subprograms (BLAS)," ACM Transactions on Mathematical Software, vol. 28, no. 2, pp. 135-151, December 2002. DOI: 10.1145/567806.567807 (228.33 KB)"


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House lawmakers soundly defeated a bill aimed at preventing property-tax increases in years that property values are depressed.
The House voted Friday, 43-65, against House Bill 89, sponsored by state Rep. Jack Franks, D-Marengo. The bill sought to forbid governments subject to the tax cap from collecting inflationary increases in years their overall assessed value decreased, except by voter referendum.
Local taxing bodies are entitled on this year's property-tax bills to a 3 percent increase over what they collected last year. While some local governments voluntarily held their levies flat, many raised their levies to capture the increase.
"I'm going to keep trying – I look at this as a temporary setback," Franks said. "This is something worth fighting for for the taxpayers."
About 60 percent of House Democrats and half of House Republicans voted against the bill, which was strongly fought by local government lobbying groups. House Minority Leader Tom Cross, R-Oswego, voted "present."
All four of McHenry County's GOP representatives – Mike Tryon, Barbara Wheeler, David McSweeney and Tim Schmitz – voted in favor of the bill.
The tax cap, or the Property Tax Extension Limitation Law, limits the annual increase that taxing bodies can receive to either the rate of inflation or 5 percent, whichever is less. State lawmakers imposed the cap on the collar counties in 1991 to rein in double-digit property taxes as home values started to soar, and five years later allowed voters in other counties to enact tax caps by referendum.
But when home values decrease – a scenario lawmakers never considered – the tax cap works for government and against the taxpayer by guaranteeing that taxing bodies can collect the inflationary increase.
Franks first filed the bill in June 2011 during the previous General Assembly, citing taxpayer outrage that their property-tax bills were increasing despite the fact their values had plummeted with the bursting of the housing bubble.
It cleared the House on the second try, but stalled in the Senate. Twenty-five of Friday's no votes – 19 Democrats and six Republicans – came from lawmakers who had voted in favor last time.
At least four other bills – three in the House and one in the Senate – aim to freeze what local taxing bodies can levy for the next three to five years. But all four of them, one of which was filed by McSweeney, are languishing in committee and are considered dead.
Government lobbying groups that fought Franks' bill include the Illinois Municipal League, the Illinois Association of School Boards and its related agencies, and Metro Counties of Illinois, to which the McHenry County Board belongs. Local governments pay their dues to these lobbying groups with taxpayer dollars.
The County Board is one of several governments that voluntarily held their levy flat to reject the 3 percent increase.
The groups argued that the legislation would hinder governments' ability to keep up with rising costs of supplies, as well as unfunded state mandates and other expenses. Government lobbying groups typically oppose legislation that would lower members' revenues, increase their expenses or take away local control.
The McHenry County Assessor's Office fielded more than 10,000 assessment appeals for property-tax bills due this year. The number of appeals each year has set successive records since the housing bubble burst. By comparison, the assessor fielded only 677 appeals a decade ago.


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And EWE Missy missykins, are the biggest Missy Prissy, sooooooo it's Bubbles or, or, or, what was that other hideous nickname u tried to saddle me with Puperoni? Aaaaaanyways, Beckykins......so glad to see you weren't mia too. And Pup, yep...that was exactly what I was alluding too with Shannikins' s brown snow. As for the cute, precious and adorable critters....here's one more!Rebecky wrote:hi peoples!
whose the stranger posting animals? holly? who?
Oh, wait...about the testimony book....AWESOME, can't wait to read it!


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Weddings Request For Information
Congratulations and thank you for considering The Lodge Resort & Spa for your wedding day!
We want you to relax, renew and enjoy your special day. Providing as much detail as possible will allow us to better understand how we may assist you.
A Landmark Choice Among New Mexico Resorts
Seasoned by a rich and cultured past, The Lodge Resort beckons you with alluring promises of intrigue. But more than that, this magnificent Cloudcroft New Mexico hotel and resort possesses a quality unlike any other retreat. From the turn-of-the-century fire that destroyed the original structure to its ghostly inhabitants to its storied past, our resort offers a haunting presence that can be felt to your very core. Inside its halls, magic moments live again and again – making this a place that never completely leaves your heart. Towering 9.000 feet above sea level, this prestigious New Mexico resort offers leisure and business travelers an entrancing location.
Specials & Packages
From a romantic rendezvous to an adventurous vacation, The Lodge offers a variety of seasonal packages designed to accommodate your every wish.
Sweetheart Special- One night's lodging in a King or Queen room (Standard-Platinum), your choice of two entrees off dinner menu in Rebecca's on lodging night (excludes table side items), Breakfast for two at Rebecca's the following morning and a complimentary bottle of Sparkling Wine. $295 inclusive. Offer valid for the month of February.
Rebecca's Retreat – One night stay in a King or Queen room (Standard-Platinum), your choice of two entrees off dinner menu in Rebecca's (excludes table side items) and a welcoming 1/2 dozen chocolate covered strawberries await you in your room. $260 inclusive Additional night available at a discount.
Rest and Relaxation – Two nights in a Queen or King room, a one hour couples massage in the Spirit of the Mountain Spa, and Chateaubriand dinner for two. $565 inclusive
Saturday Night Special – One night (Saturday) in a Queen or King room and Sunday brunch for two the next day. $208 inclusive. No Holiday Sunday brunches please
Gift certificates are available for purchase and may be used for Packages, Golf, Spa Treatments, Dining and more…Remember, the perfect gift awaits that special someone in Seasons. Gift certificates may be purchased for any amount and are redeemable for all Lodge purchases.
*Package pricing is based upon double occupancy (single occupancy rates are available) plus applicable taxes and gratuities. Packages are subject to availability. Some restrictions may apply.
Contact The Lodge:
601 Corona Place


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Best Buy has a 1 year Playstation Plus membership for $35, which is $15 off retail, and the second cheapest the subscription has been. Playstation Plus is, in our opinion, the best value in gaming. It was the most popular Black Friday deal we posted, and was the fifth most taken advantage of deal of 2013. [Best Buy]
If you're on a Microsoft console, Amazon will be taking $10 off a year of LIVE, and throwing in digital copies of The Maw, Wreckateer, Ms. Splosionman, and $5 instant video credit. That deal will be live at 3am ET, give or take 30 minutes. [Amazon]
This post is brought to you by the Commerce Team, a dedicated group of deal hunters and product enthusiasts. We operate independently of Editorial to bring you the best bargains every day, share our favorite products with you, and ask you about yours. When you buy something we recommend, we may also get a small share of the sale. We welcome your questions and want your feedback.


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At Tuskegee University Cosby Urges African Americans To Seize The Day
Cosby keynote address. He stripped off his regalia during his speech and revealed a Tuskegee University sweat suit underneath.
Calling James Brown one of the greatest songwriters, comedian and philanthropist, Bill Cosby, used soulful lyrics to inspire Black people to be more proactive and empowered.
Singing parts of Brown's funk classic "Get Up, I Feel Like Being a Sex Machine," Cosby said many Blacks have become complacent in determining their own destinies. He gave the keynote address for Tuskegee University's 2013 Homecoming/Charter Day Convocation. "Get up. Stay on the scene," Cosby sang to the audience.
Cosby said many Black people have fallen into the trap of perpetual victimhood, blaming a "mythical White man" for their inaction. He said Black American culture is under attack by people who wish to make money off of it.
Cosby said the culture has become riddled with negative images and activities, which are in opposition to its foundation of hard work, pride and determination. He encouraged having respect for Black women and rejecting obscenity.
"We're not vulgar people. We're not people who say to our daughters, 'Go ahead out there with as little clothing as possible,'" Cosby said. "Our daughters have to have strength about who they are."
Later in his remarks, Cosby turned his attention to Tuskegee's faculty and students. He said professors are the last Civil Rights fighters in America and that students should take advantage of the guidance and opportunities that are offered to them. He also said students should not be afraid or embarrassed about seeking help if they are slipping in their studies.
"All around you is faculty," Cosby said to the students. "They want you to know so you can go out there and succeed."
After his address, Cosby was given the Booker T. Washington Legacy Award by Acting Tuskegee University President, Dr. Matthew Jenkins. Later, Cosby helped raise funds for the university by appearing at a special event for donations held in the Legacy Museum.
Cosby, who is an honorary co-chair of the " Programmed for Excellence Capital Campaign for Advancing Tuskegee University," spoke to guests and posed for photos with donors.
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- Ann GarrisonFebruary 22,2018 @ 08:03 PM
I think you have "Filtered HTML" turned on here. If you switch to "Full HTML," it will probably...
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