text:
IMS is an Independent estate agent with over ten years' experience in the property industry, we deliver exceptional services for clients in Charlbury. Our flexible and personal service ensures that you are supported through the entire sales process.
Your property is marketed on Rightmove, Zoopla and PrimeLocation, as well as on social media and over 20 other portals. We work with our professional photographers to produce a high-end brochure to ensure your property is shown at its best.
IMS offer a free, no-obligation market appraisal on residential and commercial property, as well as advice on property investment, We also advise you on your onward purchase free of charge.
We have a dedicated sales progression department to make sure that your sale goes through as fast and as smoothly as possible, customer service is paramount when dealing with property.
IMS also have award-winning independent mortgage brokers, so we can search the whole of the market for the most competitive mortgage deal.
IMS is registered with the National Association of Estate Agents (NAEA) having achieved the Level 3 Technical Award in the Sale of Residential Property.
So if you are looking to sell your property, in and around the Charlbury area, please contact us on 01869 248339 or email email@example.com


text:
When December arrives, I'll share some of the cool behind-the-scenes/ how-to's from the shoot.
If you'd like help creating a home you absolutely love, contact me about our design services.
Congratulations! That's so exciting. I am going to have to pick up a copy!
Congratulations! Love you blog!! Come visit my new lifestyle blog when you get a chance...www.lovinthat.blogspot.com
You go, girl!
That's terrific!! I'm planning on having you autography my copy. Very happy for you. Michele
How exciting!!!! I can't wait to see! Oh why is it not in my mailbox yet!
Soooo exciting for you! I can not wait to get my BHG in the mail now.
That is awesome! Must go stalk my postman to see if my copy has arrived=:)
Congratulations! I can't wait to see it...my issue hasn't arrived yet.
Karen at Garden, Home and Party
Congrats! Can't wait to see it! Hope you and your family do something fun to celebrate!! Very exciting!
YAY! I can't wait to see it! I think I am going to have to go check it out in the store as it has not arrived in the mail yet - why is that? Shouldn't you get it first when you are a loyal subscriber? Congratulations Lauren - you must be over the moon ;)
Congratulations Lauren! That is super exciting- can't wait to get my copy!!
* Gee, Ms. Movie Star... NO, make that "DESIGN STAR"(!)... pretty soon you'll have people standing in lines to get YOUR AUTOGRAPH on your LATEST BOOK!!!
SOOOOO happy for you and, even tho I'm not your Mom, I'm PROUD of you like a Mom is!
HAPPY DAY, Lauren!
Linda in AZ *
I'm THRILLED for you! I will definitely look for mag this week.
I actually have a photographer coming here on Austin for photos for my website....so, I'm looking forward to the fun on Friday!
Hope you're doing well....
Lauren, yay, congratulations!!! I am so excited for you!!!
Art by Karena
Oh, how exciting!! Cannot wait to get it and see your lovely house and imagine it has transformed since then but will be so amazing to see all the styling and flowers and such (which you also do beautifully!!!). Congrats!
xo Terri
That is a great dream come true! I can't wait to see it and again, congratulations. I don't even know you personally and yet I "know" you deserve it :)
That is a great dream come true! I can't wait to see it and again, congratulations. I don't even know you personally and yet I "know" you deserve it :)
Congratulations!! I'll definitely be picking up a copy of this--you're AMAZING!!!
Alicia B.
Yay!! On my way to get a copy. Can't wait.
Congratulations! Can't wait to see it!!
Fantastic! I can't wait to see, going out to pick up a copy today. I'm sure it's amazing. Congratulations!!
Congrat's Lauren...you know I am running out to get this issue now! Cannot wait to see our lovely home! All the best on this exciting day!
Congratulations, Lauren!
Can't wait to see this issue.
Have a great day.
I meant to say "your" lovely home. I guess I have wishfull thinking that I could decorate my home like yours...Hee! : )
Congratulations Lauren!! Can't wait to pick it up!!!
oh lauren
this is SO exciting! running off to the newstands pronto. looking forward to all the "behind the scenes" posts!
(your silent/too busy friend)
yay! I can't wait until the mailman brings my copy! Congrats and thanks for the inspiration
Congratulations again!!! This is so exciting and would be a total dream come true for me as well- I'm off to pick up a copy this afternoon and can't wait to see! xo
How completely fabulous of you! I can't wait to see it - I don't think we get it here, but I'll get my husband to pick it up when he's in the US next week...
I will run out today!
Can't wait for mine to arrive!
Yay! I feel like I've been waiting forever for this issue to come out.
I can't wait to see it!
Congratulations Lauren!!!
xo xo
Coming out of lurkdom to congratulate you on the spread! Mine arrived in the mailbox on Saturday and I was so excited to see it and feel like I knew you! Congrats!
Congratulations!! We're so excited for you! This is amazing!
Whoo hoo!! Can't wait to see it in print! Congrats on all your hard work and those at BHG as well, thanks for letting me pop in here and there. It was an amazing team of talent! XO *Amy
Awesome! Can't wait to see. Huge congrats!
Congratulations Lauren!! Will you post the article on your blog? Because I will not find the magazine here in Belgium! Can't wait to see!!!
Awesome Lauren...I am so happy for you!!!! I am going to B&N to get myself a copy today..can't wait!
can't wait to go get my copy!!!
I can't wait to pick up an issue, congratulations Lauren, how exciting for you!
You must be so thrilled! Congrats! Gonna run to get it!!!
Oh i'm so happy for you! I have been following you for awhile now and when you posted a few tidbits about getting ready to do the shot I was so excited to see the article! I had since forgotten but will rush right out and get it today! Can't wait...you have once of the loveliest homes i've seen ;p
i was at the store and looked at it today!!!
congrats you superstar!!
Wow! Congrats! I've been a huge fan of yours for a while now, and just started my own (super amateur) blog. Can't wait to check out your BHG spread!
Congratulations!!!! That would be so exciting!
congrats! so exciting
Congratulations! I've been following your blog for a few months and it is well deserved!
Congratulations, Lauren! How fun and exciting. Well deserved.
So exciting, congratulations! Look forward to seeing it!
Lauren I bought one yesterday and your spread is FABULOUS!! I am so excited and thrilled for you - darling family, gorgeous home...you go girl!
Lauren, I am so excited for you! What an honor!!! I can not wait to see it!
Have a pretty day!
I just received my copy in the mail and turned to your article first....lovely! Congratulations!
Pure Style Jealousy! so great -- congratulations. Will pick up a copy tonight.
pam h
Just got mine out of the mailbox- going to check it out now! Congrats again!!!!
A very big congrats to you and your fab house!!!
Can't wait to see it!
Wow! Wow! Wow! So exciting! I am buying a copy tomorrow since mine has not arrived yet.
xo, Anne
Congratulations Lauren!! I cant wait to see the article! So thrilled for you!!
I will be checking my mailbox everyday. I can't wait until it arrives so I can see your story. I might just have to take a sneak peak at the grocery store if it does not get here soon.
Super cool!!!
Congrats! You are so deserving of that spread, girl! So happy for you.
Congratulations, can't wait to see!
Angela Williams
You should have been on the cover!
Can't wait to get mine in the mail! Congratulations - well deserved recognition.
Found you in my mailbox today, Lauren! Gorgeous - your home, your family and you! Congrats
F A N T A S T I C ... i will run and buy it tomorrow!!!
congratulations sweetie... you so deserve this... all of it!
Congratulations! I live in the UK and unable to receive this edition. Will you be posting the pages in a post?
I'm dying to see :)
Can't wait to get this issue. Congrats! I'm sure it was really a thrill to have your home featured! So happy for you. :)
Congratulations! Well-deserved. Can't wait to get my copy! Thanks for stopping by online store launch yesterday. I know you are a busy, busy girl! Mona
While grocery shopping this morning I remembered to get BH&G---your feature is beautiful. I'm so happy for you that even more people will see your talent and lovely family.
How exciting! I got my issue in the mail last week but I haven't had a chance to look at it yet - after seeing this I'm running to grab it!
I'm in the process or pepping up my home. I loved your ideas in BH and G. Your house and family are adorable! I love the positive, cheery feeling on your blog.
i feel so proud of you! your home looks amazing. i just did a post about it and you, with a couple of my favoite images from your article. enjoy the spotlight! :) Tessa
I just saw it and realized that I had been to your blog! I definitely tore out the page with your brilliant orange door, that beautiful hefty wreath and those DaVinci prints. great shot.
I remembered & picked it up Sunday night. Your home looks gorgeous. Your kiddos couldn't be any more precious. Can't wait to see the portfolio pics.
Our issue arrived in the mail yesterday afternoon, I quickly ripped off the plastic cover to find the article. Every shot picture perfect! My favorite though is the precious family photo. Congratulations and hugs.
YEAH!! I cant WAIT to get my hands on a copy to see your beautiful home!!! WOOHOOO!!
I'm SO EXICTED for you Lauren!!!!! Running to the store to grab a copy!!!! YAY!!!
Hip, hip, hooray! Can't wait to see your home all decked out for the holidays.
If you're looking Ideas for:
*** Home Design ***
*** Home Designs ***
*** Home Decor ***
*** Home Decors ***
*** Fixtures ***
*** Interior Design ***
*** Garden Design ***
*** Lighting ***
*** Furniture ***
*** Home Accessories ***
*** Curtains ***
This is the right place to go: *** www.BestHomeDecors.com *** Enjoy. ; )
It's GOR-GE-OUS! I got my hot little hands on it today! Love it! Your place looks great. you must be over the moon! enjoy! -denise
Huge congrats Lauren!!!!! No one deserves it more. I can't wait to see the article!!! Brava!
Congratulations! I got my copy. Your home is beautiful and your little kiddos so cute.
just caught your article while at the ortho with my daughter ~ it was so cool ~ like seeing your friend's house in a magazine ~ even if we are not really "friends" ~ it feels that way when you regularly read someone's blog (even if I don't regularly comment)
Picked up my copy today!!! Soooo cool! You, the fam, the house look perfect! Congrats!
Congrats sweetie, I am going to go and get mine right now!!! Yippee!!
My copy just arrived in the mail! Can't wait to sit down somewhere cozy and read all about you. I love what they've done with this magazine. So hip. So inspirational.
My copy just arrived in the mail! Can't wait to sit down somewhere cozy and read all about you. I love what they've done with this magazine. So hip. So inspirational.
Congratulations Lauren!! What well deserved press.
i had to write you a comment after receiving my bh&g yesterday! now i know why everyone was saying such wonderful things...the article about your home was stunning! i loved every single detail--and the fact that i've been following along with your blog for the last year or so only made me love it more! i am saving every picture in my inspiration file for sure! congrats!! :)
just got my copy!!! Looks sooooooo BEAUTIFUL!!!! CONGRATULATIONS!!!!! we are so excited for you!! send our love! xoxoxo
Eddie + Jaithan
I've never commented on your blog before but I've been a follower for over a year now and just wanted to let you know that I really enjoyed reading the Christmas article about you in BHG this month. Also, congrats on being it in.
I love your work and thank you for sharing it us,
I just saw your home in BHG magazine and I LOVE your Christmas monogram stockings. Can you share who or where you purchased these stockings from or are they your beautiful creation!?!? :)
congratulations lauren!!! your home is a beautiful reflection of the love and hard work you put into it! the issue is one of my faves! xo
Got my copy yesterday. Such a nice article! Your talent shows.
That is how I found your blog.
As a decorator & a textile designer, this is my place to muse... perfection doesn't interest me; Reality and charm do. Fresh floppy flowers from the garden over long-stemmed roses any day, I love it when things are slightly off and tell a story.

subset: commoncrawl


text:
You are here, Viewing: Musixmatch - Lyrics for your music Premium 7.0.1 Final APK
App Name: Musixmatch - Lyrics for your music
Version: 7.0.1 Premium
Package Name: com.musixmatch.android.lyrify
Requirements: Android 4.0 and up
File Size: 13.7 MB
www.underclassblog.com — Musixmatch is the world's largest collection of song lyrics used by millions of people to get instant synchronised lyrics for Youtube, Spotify, Pandora and more.
You can also now use it to get song translations on the go.
Musixmatch lets you:
• Enjoy song lyrics with music from Spotify, Youtube, Pandora, Apple Music, SoundCloud, Google Play Music and all your other favourite streaming services
• Tap on the real- time notification to display the Floating Lyrics widget and get the current track's lyrics
• Easily learn new languages by displaying the translation of the lyrics, in time with music.
• Identify and get the lyrics to any song that's playing around you with one tap
• Search for your favourite song by title, artist and even just using a single line of the lyrics
With Musixmatch you can also:
• Use the smart seek to find your favourite lyrics by easily skipping through a song using the the progress bar
• Share your favourite song lyrics on amazing backgrounds with the LyricsCard feature
• Play Youtube videos in full screen, on landscape mode, to enjoy the FloatingLyrics fully integrated with the video
• Play, pause, skip track from your lock screen
• Get notified instantly when new lyrics from your favourite artists are available
• Quickly and easily find all your favorites on your profile
• Preview songs or watch their Youtube videos
• Collect your identified songs in a Spotify playlist
• Join our Community so you can submit all your favourite lyrics, put them in time with music and even have fun translating them
• Fetch song info and cover art for your songs.
For listeners on the go, you can fire up a song from your favorite music app and automatically get the lyrics on the Lock Screen.
Try the Musixmatch Lock Screen with Spotify, Play Music or any other music app.
By enabling it, you can even control the music and have the identifying lyrics button just one tap away.
• Musixmatch is available on your Android Wear devices
• Enjoy Musixmatch at home casting local music and lyrics to your TV with Chromecast
Offline lyrics - enjoy all the lyrics you have viewed without a connection.
No ads - get all the lyrics with no ads.
No commitment - cancel any time you like.
Not sure where to start?
Be sure to have enabled the FloatingLyrics and let Musixmatch find lyrics for your songs on Spotify, Pandora, Play music, Youtube, SoundCloud and more.
Love Musixmatch? Don't miss our updates:
The best Music Player as for AndroidPolice, Android Authority and The Next Web.
"Best Apps 2014 and 2015" selection on Google Play Store.
+50,000,000 people enjoying their Music with the power of Lyrics
Google Play Editor Choice with +1,2 mln 5 stars reviews
*We only ask for the permissions we need for the app to be at its best.
Musixmatch requests the "Notification access" permission only to listen for music.
We're excited to announce the release of version 7.0 of Musixmatch, which offers a new look and feel, enhanced functionality, a more seamless lyrics discovery experience, and some dramatic improvements.
Here are the new features you'll love:
New Home for your recommended content
Beautifully redesigned FloatingLyrics™
NOTE: If you experience difficulties with downloading Musixmatch - Lyrics for your music Premium 7.0.1 Final APK from given links below, please try to login first to those file hosting before download (it's free to create an account), make sure to uncheck "Use our download manager and get recommended downloads" or similar, if any.
Musixmatch Lyrics Premium 7.0.1 Final APK Posted on: http://www.underclassblog.com/2017/12/musixmatch-lyrics-premium-7-0-1-apk.html


text:
Liberty News
Liberty increases support for Operation Christmas Child
"Around the world," said Sherry McFaden, Operation Christmas Child's (OCC) coordinator for Central Virginia, "children's lives will be changed by the gifts they receive because Liberty University students chose to give."
This year alone, individuals from the Liberty community have donated more than 1,100 shoebox gifts full of toys, clothes and many other items for children in impoverished areas around the world. According to McFaden, this is a 250-box increase from last year.
Almost 18,000 shoeboxes have been collected in the Lynchburg area alone, which is 17 percent more than 2009. As of Dec. 3, OCC has processed more than 2.6 million gifts this season alone. The goal for 2010 is 8.5 million gifts to children in more than 130 countries.
OCC is operated by Samaritan's Purse, which was founded in 1970 by evangelist and journalist Bob Pierce. After his death in 1978, the Rev. Franklin Graham took over as chairman and president of the organization and began OCC in 1993.
In nearly 20 years, OCC has collected more than 77 million gifts for children in need around the world.
National Collection week is over, but you can still pack a shoebox online and customize the gift based on gender, age gift type.


text:
Mishawaka Packing and Moving Services
Need a Mishawaka moving company for your next move or relocation? Let us make the transition an easy one.
My Movers offers a wide variety of relocation services:
-Loading the truck
-Moving your entire home
We are your residential movers. My Movers can take care of all of your residential moving needs. Whether you are moving across town or across the country we ease the stress of long distance moves.
My Movers are South Bend and Indianapolis natives, and serve a wide range of areas:
Let My Movers be your professional service for home moves.
At My Movers, full service moving is our specialty. We handle every aspect of your household or commercial move. Our residential and commercial movers pack, load, and transport your entire home for one low price. Call My Movers to get a free moving quote. As one of the premier movers in Indiana, we commit to giving you the best service possible. We provide efficient, professional, and affordable residential moving services.
Our professional movers understand the potential complications and headaches that go along with moving. Let us assist your residential move and make it as stress free as possible.
Worried about location? Our central locations in Mishawaka and Carmel allows us to serve the South Bend and Indianapolis areas.
Looking for a few helping hands or a large truck and boxes? My Movers can be your professional movers and packers. Contact us today to get a free moving quote or consult with a moving expert about your upcoming move.


text:
The diverse product portfolio from ZIEHL-ABEGG offers the best and most energy efficient solutions for almost any requirement and application in the field of renewable energy. From wind-driven power stations to bio-heating systems and photovoltaic systems, the modern, highly efficient fans developed using bionic insights and with precisely coordinated control engineering can be used in various application areas.
Renewable energies
The pioneering energy sources from ZIEHL-ABEGG create the best conditions for sustainable and efficient energy supply.


text:
Knight black and white cliparts
You can get acquainted with the presented collection of Knight black and white cliparts to choose suitable ideas for your business or design interface.
Today we have 23 cliparts and vectors for this category.
Advice on how to make a good presentation
Use no more than 3 fonts on one slide
People don't like to see more than 3 types of fonts on one slide but let's emphasise that using more than one particular type of font is likely to be already out of line. There are so many other ways of differentiation which you can use instead of varying fonts.
The drawbacks of varying fonts include:
- It disrupts the harmony of your presentation and will make it look bad
- Each different font has its respective sizing which would make them look silly when featured together
- Find alternate ways to emphasise your content: with size or with color or a simply underlining or bracketing is more than enough.


text:
Efficacy and Safety Study of Clozapine Augmented by Atomoxetine Versus Clozapine Augmented by Placebo in Patients With Chronic Resistant Schizophrenia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00216281
Recruitment Status : Terminated
First Posted : September 22, 2005
Last Update Posted : March 26, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Drug: Clozapine augmented with atomoxetine up to 40 mg or placebo
|Phase 3
The purpose of this study is to scientifically explore the potential of pharmacogenetic applications as a means of predicting the clinical efficacy and safety of treatment with clozapine and atomoxetine in a treatment resistant schizophrenic population.
The principle enzyme involved in the metabolism of clozapine is CYP1A2 with minor contributions from CYP2D6. However, all the subjects will be on a stable dose of clozapine and will continue on the same dosage throughout the study. On the other hand, half the number of subjects will be randomized to augmentation with atomoxetine and since atomoxetine is predominantly metabolized by CYP2D6 with contributions from CYP2C19, we will focus on genetic variations for CYP2D6 and CYP2C19.
The goal of this study is to associate atomoxetine and metabolite drug concentrations with clinical efficacy and the development of any clinical adverse drug reactions and to determine whether clinical outcome (efficacy and ADRs) experienced following drug ingestion are more likely to be seen in patients who manifest CYP2D6 and/or CYP2C19 polymorphism(s). Other indications for pharmacogenetics in patient care, relevance of therapeutic drug monitoring, augmentation strategies and dosage guidelines may be generated from the experience and results of this study.
Primary Objectives
- To compare the effects of the combination of CLZ+ATX on cognitive function in patients with schizophrenia, as measured by change in a Composite Cognitive index derived from a battery composed of standardized cognitive tests, the Brief Assessment of Cognition in Schizophrenia..
- A total sample of 126 subjects diagnosed with schizophrenia and being treated with the antipsychotic clozapine, will be recruited to participate in the study. All 126 subjects will undergo genetic testing after obtaining informed consent, for 31 known mutations in CYP2D6 including gene duplication and deletion as well as, two mutations in CYP2C19.
Secondary Objectives
- Determine the concentration of atomoxetine and its two prominent metabolites (4-hydroxyatomoxetine, and N-desmethylatomoxetine) at the end of week one and four weeks after initiating therapy by LC/MS/MS analysis.
- Obtain weekly complete blood counts and CLZ levels on screening, at the end of week one and week four.
- Clinically evaluate patients and document any adverse drug reactions that occur after starting treatment with atomoxetine
- To examine the effects of the combination of CLZ+ATX on psychopathology as measured by the Positive and Negative Syndrome Scale (PANSS) scores (PANSS Total, PANSS Positive, PANSS Negative), the Montgomery-Asberg Depression Rating Scale and the Clinical Global Impressions-Improvement Scale
- To examine the effects of the combination of CLZ+ATX on measures of social cognition: Penn Emotional Recognition and Facial Memory Tests.
- To compare the effects of the combination of CLZ+ATX on weight change from baseline.
- To examine the effects of the combination of CLZ+ATX on daily functioning as measured by the NOSIE.
- To examine the effects of the combination of CLZ+ATX on extrapyramidal signs and motor symptoms as measured by the Barnes Akathesia Rating Scale (BARS), the Abnormal Involuntary Movement Scale (AIMS), and the Simpson-Angus Scale (SAS).
- To evaluate the safety of the combination of CLZ+ATX as measured by treatment-emergent adverse events and changes in vital signs, clinical laboratory analytes, and electrocardiogram.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|126 participants
|Intervention Model:
|Parallel Assignment
|Double (Participant, Investigator)
|Primary Purpose:
|Official Title:
|Correlation of Phenotype, Genotype and Clinical Efficacy/Toxicity of Clozapine Augmented by Atomoxetine for Treatment Refractory Schizophrenia (CAPG Study)
|Study Start Date :
|September 2005
|Actual Primary Completion Date :
|October 2006
|Actual Study Completion Date :
|September 2008
Active Comparator: clozapine with AZT added
Clozapine augmented with Atomoxitine up to 40mg
Drug: Clozapine augmented with atomoxetine up to 40 mg or placebo
Placebo Comparator: placebo
Subjects will have a placebo pill added to their clozapine regimen.
Drug: Clozapine augmented with atomoxetine up to 40 mg or placebo
- Impact of treatment will be based on clinical examination, laboratory values, and rating scales including, PANSS, CGI, AIMS, BAS, SAS, cognitive measures, NOSIE. [ Time Frame: 375 days ]Via rating scales and cognitive measures, effects of CLZ and ATZ on congitive function will be assessed. A total of 126 suybjets diagnosed with Schizophrenia will be recruited, consented, and treated with CLZ and ATZ. They will undergo genetic testing for 31 mutations of CYP2D6 including gene duplication and deletion as well as, two mutations in CYP2C19.
- Concentrations [ Time Frame: week 1 and week 4 ]Determine the concentration of atomozetine and its two prominent metabolites
- blood cell counts [ Time Frame: week 1 and week 4 ]Obtain complete blood counts and CLZ levels on screening and at week 1 and 4
- adverse events [ Time Frame: day one forward ]clincal evaluation for adverse drug interactions that occur with the start of atomoxetine
- symptom measure [ Time Frame: screen, day 1 and all f/u visits ]Panss, MADRS and CGI scales completed at each visit
- social cognition [ Time Frame: screening, day 1 and f/u visits ]assessment of cognitive function via Penn Emotional REcognition and facial memory tests.
- weight change [ Time Frame: day one and follow up visits ]measures of weight change from baseline.
- daily functioning [ Time Frame: baseline through f/u visits ]measure of daily functioning via the NOSIE and extrapyraminal/motor signs via the BARS and AIMS scales
- adverse events 2 [ Time Frame: baseline forward ]evaluation via vital signs, clinical labs and ECG for safety
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of Schizophrenia that meets the diagnostic criteria as defined in the Diagnostic and Statistical Manual of Mental Disorders (4th edition, text revision) (DSM-IV-TR), APA 2000).
- Adult (18-65) males or females with a confirmed primary diagnosis of schizophrenia.
- Stable symptoms as determined by a score of 70 or less on the PANSS.
- Women of child bearing potential must be using a medically accepted means of contraception.
- Adequate cognitive function (IQ > 65) as assessed by the WRAT3, with a level of understanding sufficient to perform all tests and examinations required by the protocol.
- Considered reliable.
Stable on clozapine treatment. Criteria for stability defined as follows:
- Patients should have been taking oral clozapine daily for the last 4 weeks (with no change in clozapine dose in the 4 weeks prior to screening).
- Patients must not require chronic add-ons or have taken "as needed" antipsychotic or antidepressant medications in the last four weeks to control agitation, behavioral disturbance, or primary psychiatric symptomatology.
- There must have been no significant change in the level of care required, caused by worsening of schizophrenia in the last four weeks. For example any escalation from lesser to greater intensity of treatment or ER visits.
- Patients must not be taking any additional psychotropic medications including health food supplements judged by the investigator to be likely to have central nervous system activity (for example, St. John's Wort, ginkgo biloba leaf, melatonin).
- Patients must not have received a depot antipsychotic within the past 8 weeks days.
- Each patient must be judged competent and able to understand the nature of the study and must sign an informed consent document prior to participation in the study.
- Patients must be able to swallow medications.
Exclusion Criteria:
- Clinically significant organic disease that, in the opinion of the investigator, would put the patient at significant risk from study procedures or interfere with data interpretability. This includes hepatic (specifically any degree of jaundice), renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease), endocrinologic, neurologic, or immunologic conditions.
- Potentially serious or unstable medical condition that is likely to require excluded medications or other significant treatment during the course of this treatment.
- Patients who have not tolerated atomoxetine in the past or have history of clinically significant adverse effect(s) during prior treatment with atomoxetine.
- Patients who have not tolerated oral CLZ in the past or experienced significant adverse effect(s) in the past.
- History of non-response to clozapine (treatment refractory) defined as unambiguous lack of improvement despite contiguous adequate trial of at least 14 weeks of treatment.
- Clozapine blood levels outside the optimum CLZ plasma levels of 350 to 400 ng/ml.
- Women who are pregnant, breastfeeding, or refuse to use adequate birth control.
- Significant risk of suicidal behavior or pose an imminent significant threat to others, at the time of screening.
- History of alcohol or drug dependence (except nicotine and caffeine) that meets DSM IV criteria, within the past six months or have a history of drug or alcohol abuse within the past 30 days. Patients who have history of cannabis use for recreational purposes may be enrolled if in the opinion of the PI, the drug use pattern is not primarily related to a psychiatric condition or diagnosis.
- Have abnormal blood pressure in the opinion of the investigator.
- Electrocardiograms (ECGs) outside the normal limits.
- Abnormal clinical laboratory test results outside the normal range.
- History of agranulocytosis (absolute neutrophil count <500 mm3).
- Uncorrected hypothyroidism, hyperthyroidism or abnormal thyroid-stimulating hormone (TSH) concentrations. Patients previously diagnosed with hyperthyroidism or hypothyroidism who have been treated on a stable dose of thyroid supplement for at least 3 months, have medically appropriate TSH concentrations, and who are clinically euthyroid are allowed.
- History of clinically significant head injury.
- History of allergic reaction to clozapine or atomoxetine or any condition that could be aggravated by treatment with these medications (for example, narrow-angle glaucoma, urinary retention or hesitancy).
- one or more seizures without a clear and resolved etiology.
- Hearing or visual impairment severe enough to interfere with performance on cognitive tests.
- Patients who have taken a monoamine oxidase inhibitor (MAOI) drug (for example Nardil™, Parnate™, or Eutron™ for depression) or tryptophan within the last 2 weeks prior to screening.
- History of electroconvulsive therapy within the previous year.
- History of mental retardation.
- Have grade-level equivalent score of less than 8th grade as determined by WRAT3. This means that a patient must have a raw score of 40 or above (IQ equivalent of 81) in order to qualify.
- Have received treatment within the last 30 days with a drug that has not received regulatory approval for any indication at the time of study entry.
- Investigator site personnel directly affiliated with the study, or are immediate family of investigator site personnel directly affiliated with the study. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Patients who, in the opinion of the investigator, are unsuitable in any way to participate in this study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00216281
|United States, Indiana
|LaRue Carter Hospital
|Indianapolis, Indiana, United States, 46222
|Principal Investigator:
|Anantha Shekhar, MD, PhD
|Indiana University School of Medicine
|Responsible Party:
|Indiana University School of Medicine
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 22, 2005 Key Record Dates
|Last Update Posted:
|March 26, 2013
|Last Verified:
|March 2013
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Atomoxetine Hydrochloride
Adrenergic Uptake Inhibitors
Neurotransmitter Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Neurotransmitter Agents
Physiological Effects of Drugs
Serotonin Antagonists
Serotonin Agents
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
GABA Antagonists
GABA Agents


text:
June 7, 2000, Section A, Page 31Buy Reprints
Economists who have ventured into the alleged real world often quote Princeton's Alan Blinder, who has formulated what he calls ''Murphy's Law of economic policy'': ''Economists have the least influence on policy where they know the most and are most agreed; they have the most influence on policy where they know the least and disagree most vehemently.'' It's flip and cynical, but it's true.
Consider, on one side, really tough issues -- where there are plausible arguments on both sides, where nobody really knows how to measure the tradeoffs. Should Microsoft be broken up and, if so, how? Should Britain adopt the euro? Let's ask the economists! And those economists who are prepared to express strong opinions on such inherently ambiguous questions command rapt attention.
On the other side, consider an article that appeared in yesterday's New York Times, ''In San Francisco, Renters Are Supplicants.'' It was an interesting piece, with its tales of would-be renters spending months pounding the pavements, of dozens of desperate applicants arriving at a newly offered apartment, trying to impress the landlord with their credentials. And yet there was something crucial missing -- specifically, two words I knew had to be part of the story.
Not that I have any special knowledge about San Francisco's housing market -- in fact, as of yesterday morning I didn't know a thing about it. But it was immediately obvious from the story what was going on. To an economist, or for that matter a freshman who has taken Economics 101, everything about that story fairly screamed those two words -- which are, of course, ''rent control.''
After all, the sort of landlord behavior described in the article -- demanding that prospective tenants supply resumes and credit reports, that they dress nicely and act enthusiastic -- doesn't happen in uncontrolled housing markets. Landlords don't want groveling -- they would rather have money. In uncontrolled markets the question of who gets an apartment is settled quickly by the question of who is able and willing to pay the most. And so I had no doubts about what I would find after a bit of checking -- namely, that San Francisco is a city where a technology-fueled housing boom has collided with a draconian rent-control law.
The analysis of rent control is among the best-understood issues in all of economics, and -- among economists, anyway -- one of the least controversial. In 1992 a poll of the American Economic Association found 93 percent of its members agreeing that ''a ceiling on rents reduces the quality and quantity of housing.'' Almost every freshman-level textbook contains a case study on rent control, using its known adverse side effects to illustrate the principles of supply and demand. Sky-high rents on uncontrolled apartments, because desperate renters have nowhere to go -- and the absence of new apartment construction, despite those high rents, because landlords fear that controls will be extended? Predictable. Bitter relations between tenants and landlords, with an arms race between ever-more ingenious strategies to force tenants out -- what yesterday's article oddly described as ''free-market horror stories'' -- and constantly proliferating regulations designed to block those strategies? Predictable.
And as for the way rent control sets people against one another -- the executive director of San Francisco's Rent Stabilization and Arbitration Board has remarked that ''there doesn't seem to be anyone in this town who can trust anyone else in this town, including their own grandparents'' -- that's predictable, too.
None of this says that ending rent control is an easy decision. Still, surely it is worth knowing that the pathologies of San Francisco's housing market are right out of the textbook, that they are exactly what supply-and-demand analysis predicts.
But people literally don't want to know. A few months ago, when a San Francisco official proposed a study of the city's housing crisis, there was a firestorm of opposition from tenant-advocacy groups. They argued that even to study the situation was a step on the road to ending rent control -- and they may well have been right, because studying the issue might lead to a recognition of the obvious.
So now you know why economists are useless: when they actually do understand something, people don't want to hear about it.


text:
Unity: Crooked I Speaks With Juice About Getting The West Coast Back On Top Again! "Its Not Going To Take 1 Person"
Juicetv reports "Juice touched down during the Slaughterhouse Videoshoot. Check out exclusive Footage right here on JuiceTV."
Please click the "Report" button below if the video on this page is not working properly.
Comments will only be displayed by verified emails. No Spamming or Racism.


text:
Good News!
All this American League Tiger, Yankees, Red Sox talk has left many of you feeling under served. I feel your pain. So let me digress on to something that is more factual than speculative: the absolute embarrassment of a ballclub known as the Cubs.
Being a Cardinal fan in Chicago is not easy. Luckily, I live on the Southside, surrounded by fellow, like-minded Champions who know what it feels like to win a World Series this decade. Our hearts and souls are aligned with victory and yes, we share a common enemy:
Of course, it would be too easy for me to start ripping the Cubs before the season even starts. Instead, I'd like to share some good news with all of you Cub fans out there. So let me start with the very best news: Ryan Dempster guaranteed you a World Series championship this year! He followed that by moving faster than a locomotive, leaping tall buildings in a single bound and sticking his foot in his gargantuan mouth. I think responsible athletes usually tend to keep their mouths shut when it comes to making colossal statements of absolute assurance. Keyword: responsible.
Oh, but wait, there's definitely more good news in Cubs camp: Aramis Ramirez really enjoys cockfighting! Yeah, he really does. In fact, he said he's passionate about it. He loves it. He's been active in this archaic act of animal cruelty for a long time in his native Domincan Republic. Oh, but don't worry, Cub fans, he's not going to be in any trouble. No, I mean, he's no Michael Vick or anything like that. You see, it's okay because it's legal to stage cockfights in the Domincan…and so is kidnapping, corruption and blackmail. It's all good. Nothing to be worried about. Nothing at all.
But that's not all, Cub fans! No, there's much more to be excited about! Mark Prior is gone! That means you only have one excuse for why you don't win a championship this year and his name is Kerry Wood. For years, all I've heard about is Prior & Wood, Prior & Wood, if only Prior & Wood were healthy we'd win it all blah blah blah. Well, now the only one you have to get healthy is Wood and so far so good! Of course, the season hasn't started yet, and we all know how well he can get through a whole 162 game season, even out of the bullpen, so yeah, good luck with that. (for more info on how well Prior will do now that he's out of Wrigleyville, check out Bold & Bolder, #1.)
And I'm not done delivering the good news, Cub fans. Yes, there's more and you'll be super happy about this: You can still drink at Wrigley Field! Yes! Everyone knows how well behaved Cub fans are while taking in an afternoon with their favorite drink and favorite team, especially those upright citizens in the bleacher seats. So despite a major movement to ban alcohol at the stadium, fear not, for the good times will continue. For an exclusive look at mentioned good times watch this Youtube video to see just how mild mannered the Wrigley faithful can be. Awesome!
So, as you see, Cub fans, things are looking up on the Northside. Of course, I could throw in some cheap shots to bring you down but I would never even think of doing that. For example, I wouldn't remind everyone that there is that goat curse thing that's been dawdling on since the 40s. No. And I couldn't even think about mentioning that bland sense of apathy that lingers over the hot, stale Wrigley crowd on summer afternoons where there just happens to be a ballgame going on that, believe it or not, often interferes with the whole drinking vibe. And I guess I wouldn't even dare bring up the fact that this will be the 100th consecutive year without winning a championship. And, no, you don't have to worry about me reminding you about all the great player moves your team is famous for, like trading Brock for Broglio or letting Greg Maddux go or Lee Smith or Dennis Eckersely or any number of the myriad talents that became big stars elsewhere. No, I won't bring up any of that but I will say that I am quite sure Jacque Jones will be considered one of those stars now that no one will be using his head for target practice in right field.
It's true, Cub fans. It's going to be a great year. Can you feel the excitement? You have a lot to look forward to, including seeing me standing tall and proud in your stadium with the Birds on the Bat this summer. Don't worry, I'll have two beers in my hands too. It's gonna be awesome.
And the most awesome part of the whole season will be hearing the quiver of fear in Ron Santo's voice as he tries to pronounce Fukudome without seriously offending the entire Chicagoland area.
I can't wait for that.
Don't hate me 'cuz I'm right.


text:
Ed Sheeran says he is available for royal wedding as he collects gong
Global superstar Ed Sheeran has said he would be happy to play the first song at Prince Harry and Meghan Markle's wedding reception.
After receiving an MBE for a glittering music career and his charity work, the singer-songwriter said he had not been asked by the prince and his fiancee to perform at the special one-off gig in May.
But asked if he would like to do it, he replied with a grin: "Yeah, why not?"
So will @edsheeran be playing the first song at Harry and Meghan's wedding?— PA Showbiz (@PAshowbiz) December 7, 2017
"Yeah, why not?" pic.twitter.com/UoyMPeEsdB
Sheeran's MBE was presented by the Prince of Wales during a Buckingham Palace investiture ceremony.
The music star, who has enjoyed phenomenal worldwide success, spoke about his grandfather, Bill Sheeran, after the ceremony.
He said: "Do you know what I love? My grandfather was a massive royalist, he had all the commemorative plates and stuff, and he died on this day four years ago, so it's actually quite a nice full-circle thing. I guess he'd be pretty proud."
Sheeran's career took off after the release of his debut CD in 2011 and since that time the 26-year-old has notched up three number one singles, along with three chart-topping albums.
His songwriting skills have seen him collaborate with artists like Taylor Swift and he penned the hit Love Yourself for Justin Bieber. He has also worked with US rapper Eminem.
Asked about the secret of his success, he played down his achievements, saying: "I think it's persistence.
"I don't have a vast amount of talent compared to other people, I think talent is like 30% of it and persistence, drive and self-belief are the other ones, which I guess are all the same thing."
Charles was impressed by the musician's globe-trotting activities as he was due to fly to New York later for a gig on Friday.
Sheeran, who looked smart in a morning suit, said of his brief chat with the prince: "He was asking me if I was still selling lots of records and I told him I've got a concert in New York tomorrow, and he was quite surprised I was flying after this."
As a young boy Sheeran set his sights on becoming a performer and in his teenage years he pursued his dream, endlessly gigging and later releasing songs as he tried to gain a foothold in the music business.
His efforts caught the attention of Elton John and Jamie Foxx, who both supported the fledgling musician.
After signing for a major label his debut album, + or Plus, sold six million copies and featured the hit single The A Team, which earned the musician the 2012 Ivor Novello Award for best song musically and lyrically.
Other accolades followed the release of his second album, X or Multiply, which won the 2015 Brit Award for album of the year, and Sheeran was also presented with an Ivor Novello Award for songwriter of the year.
He won two Grammy Awards at the 2016 ceremony for song of the year, Thinking Out Loud, and best pop solo performance.
Sheeran's latest single, Perfect, newly re-worked as a duet with Beyonce, is expected to top the charts this week.
Speaking about the prospect of his fourth number one, Sheeran said: "Do you know what, it's mad.
"Starting the year with a number one single and ending it with a number one single – I've never done that before.
"I'm very excited but I think it might have something to do with putting Beyonce on the song, I won't take full credit."
Sheeran was also enthusiastic about his time working with Eminem on the American's latest album, describing the experience as "really amazing".
The singer-songwriter added: "He was someone I obviously grew up listening to and have a huge amount of respect for.
"But he's such a sweet nice guy, really friendly, proper family man, very musical, I really enjoyed my time with him."
Sheeran's MBE also recognised his charity work and he has supported a range of organisations including East Anglia's Children's Hospices, acting as an ambassador.
He said he was dashing off to have a celebratory curry with his parents, John and Imogen Sheeran, in central London, before catching his flight to New York.


text:
5 U.S.C. 551-558, 701-721; 15 U.S.C. 1451-1461; 21 U.S.C. 141-149, 321-393, 467f, 679, 821, 1034; 28 U.S.C. 2112; 42 U.S.C. 201, 262, 263b-263n, 264.
The procedures in this part apply when—
(a) The Commissioner concludes, as a matter of discretion, that it is in the public interest to hold a public hearing before a Public Board of Inquiry (
(b) Under specific sections of this chapter a matter before FDA is subject to a hearing before a Board; or
(c) Under § 12.32, a person who has a right to an opportunity for a formal evidentiary public hearing waives that opportunity and requests that a Board act as an administrative law tribunal concerning the matters involved, and the Commissioner decides to accept this request.
If the Commissioner determines that a Board should be established to conduct a hearing on any matter, a notice of hearing will be published in the
(a) If the hearing is under § 13.1 (a) or (b), all applicable information described in § 12.32(e).
(1) Any written document that is to be the subject matter of the hearing will be published as a part of the notice, or the notice will refer to it if the document has already been published in the
(2) For purposes of a hearing under § 13.1 (a) or (b), all participants who file a notice of participation under § 12.32(e)(6)(ii) are deemed to be parties and entitled to participate in selection of the Board under § 13.15(b).
(b) If the hearing is in lieu of a formal evidentiary hearing, as provided in § 13.1(c), all of the information described in § 12.32(e).
(a) All members of a Board are to have medical, technical, scientific, or other qualifications relevant to the issues to be considered, are subject to the conflict of interest rules applicable to special Government employees, and are to be free from bias or prejudice concerning the issues involved. A member of a Board may be a full-time or part-time Federal Government employee or may serve on an FDA advisory committee but, except with the agreement of all parties, may not currently be a full-time or part-time employee of FDA or otherwise act as a special Government employee of FDA.
(b) Within 30 days of publication of the notice of hearing, the director of the center of FDA responsible for a
(1) Any two or more persons entitled to nominate members may agree upon a joint list of five qualified nominees.
(2) The lists of nominees must be submitted to the persons entitled to submit a list of nominees under this paragraph but not to all participants. Within 10 days of receipt of the lists of nominees, such persons may submit comments to the Division of Dockets Management on whether the nominees of the other persons meet the criteria established in paragraph (a) of this section. A person submitting comments to the Division of Dockets Management shall submit them to all persons entitled to submit a list of nominees.
(3) The lists of nominees and comments on them are to be held in confidence by the Division of Dockets Management as part of the administrative record of the proceeding and are not to be made available for public disclosure, and all persons who submit or receive them shall similarly hold them in confidence. This portion of the administrative record remains confidential but is available for judicial review in the event that it becomes relevant to any issue before a court.
(c) After reviewing the lists of nominees and any comments, the Commissioner will choose three qualified persons as members of a Board. One member will be from the lists of nominees submitted by the director of the center and by any person whose petition was granted and is the subject of the hearing. The second will be from the lists of nominees submitted by the other parties. The Commissioner may choose the third member from any source. That member is the Chairman of the Board.
(1) If the Commissioner is unable to find a qualified person with no conflict of interest from among a list of nominees or if additional information is needed, the Commissioner will request the submission of the required additional nominees or information.
(2) If a person fails to submit a list of nominees as required by paragraph (b) of this section, the Commissioner may choose a qualified member without further consultation with that person.
(3) The Commissioner will announce the members of a Board by filing a memorandum in the record of the proceeding and sending a copy to all participants.
(d) Instead of using the selection method in paragraphs (b) and (c) of this section, the director of the center, the other parties to the proceeding, and any person whose petition was granted and is the subject of the hearing, may, with the approval of the Commissioner, agree that a standing advisory committee listed in § 14.80 constitutes the Board for a particular proceeding, or that another procedure is to be used for selection of the members of the Board, or that the Board consists of a larger number of members.
(e) The members of a Board serve as consultants to the Commissioner and are special Government employees or Government employees. A Board functions as an administrative law tribunal in the proceeding and is not an advisory committee subject to the requirements of the Federal Advisory Committee Act or part 14.
(f) The Chairman of the Board has the authority of a presiding officer set out in § 12.70.
(a) The proceeding of a Board are subject to the provisions of § 10.55 relating to separation of functions and ex parte communications. Representatives of the participants in any proceeding before a Board, including any members of the office of the Chief Counsel of FDA assigned to advise the center responsible for the matter, may have no contact with the members of the Board, except as participants in the proceeding, and may not participate in the deliberations of the Board.
(b) Administrative support for a Board is to be provided only by the office of the Commissioner and the office of the Chief Counsel for FDA.
(a) Submissions are to be filed with the Division of Dockets Management under § 10.20.
(b) The person making a submission shall serve copies of it on each participant in the proceeding, except as provided in §§ 13.10(b)(2) and 13.45. Submissions of documentary data and information need not be sent to each participant, but any accompanying transmittal letter, summary, statement of position, certification under paragraph (d) of this section, or similar document must be.
(c) A submission must be mailed to the address shown in the notice of appearance or personally delivered.
(d) All submissions are to be accompanied by a certificate of service, or a statement that service is not required.
(e) No written submission or other portion of the administrative record may be held in confidence, except as provided in §§ 13.10(b)(2) and 13.45.
(f) A participant who believes that compliance with the requirements of this section constitutes an unreasonable financial burden may submit to the Commissioner a petition to participate in forma pauperis in the form and manner specified in § 12.82.
(a) Before the notice of hearing is published under § 13.5, the director of the center responsible for the matters involved in the hearing must submit to the Division of Dockets Management—
(1) The relevant portions of the existing administrative record of the proceeding. Portions of the administrative record not relevant to the issues in the hearing are not part of the administrative record;
(2) A list of all persons whose views will be presented orally or in writing at the hearing;
(3) All documents in the director's files containing factual information, whether favorable or unfavorable to the director's position, which relate to the issues involved in the hearing.
(4) All other documentary information relied on; and
(5) A signed statement that, to the best of the director's knowledge and belief, the submission complies with this section.
(b) Within the time prescribed in the notice of hearing published under § 13.5, each participant shall submit to the Division of Dockets Management all information specified in paragraph (a)(2) through (5) of this section and any objections that the administrative record filed under paragraph (a)(1) of this section is incomplete. With respect to the information specified in paragraph (a)(3) of this section, participants are to exercise reasonable diligence in identifying documents in files comparable to those described in that paragraph.
(c) The submissions required by paragraphs (a) and (b) of this section may be supplemented later in the proceeding, with the approval of the Board, on a showing that the views of the persons or the material contained in the supplement was not known or reasonably available when the initial submission was made or that the relevance of the views of the persons or the material contained in the supplement could not reasonably have been foreseen.
(d) The failure to comply substantially and in good faith with this section in the case of a participant constitutes a waiver of the right to participate further in the hearing and in
(e) The Chairman rules on questions relating to this section. Any participant dissatisfied with a ruling may petition the Commissioner for interlocutory review.
(a) The purpose of a Board is to review medical, scientific, and technical issues fairly and expeditiously. The proceedings of a Board are conducted as a scientific inquiry rather than a legal trial.
(b) A Board may not hold its first hearing until after all participants have submitted the information required by § 13.25.
(c) The Chairman calls the first hearing of the Board. Notice of the time and location of the first hearing is to be published at least 15 days in advance and the hearing will be open to the public. All participants will have an opportunity at the first hearing to make an oral presentation of the information and views which in their opinion are pertinent to the resolution of the issues being considered by a Board. A participant's presentation may be made by more than one person. The Chairman determines the order of the presentation. Participants may not interrupt a presentation, but members of the Board may ask questions. At the conclusion of a presentation, each of the other participants may briefly comment on the presentation and may request that the Board conduct further questioning on specified matters. Members of the Board may then ask further questions. Any other participant may be permitted to ask questions if the Chairman determines that it will help resolve the issues.
(d) The hearing is informal and the rules of evidence do not apply. No motions or objections relating to the admissibility of information and views may be made or considered, but other participants may comment upon or rebut all such information and views. No participant may interrupt the presentation of another participant for any reason.
(e) Within the time specified by the Board after its first hearing, participants may submit written rebuttal information and views in accordance with § 13.20. The Chariman will then schedule a second hearing, if requested and justified by a participant. A second hearing, and any subsequent hearing, will be called only if the Chairman concludes that it is needed to fully and fairly present information that cannot otherwise adequately be considered and to properly resolve the issues. Notice of the time and location of any hearing is to be published at least 15 days in advance. The hearing is open to the public.
(f) A Board may consult with any person who it concludes may have information or views relevant to the issues.
(1) The consultation may occur only at an announced hearing of a Board. Participants have the right to suggest or, with the permission of the Chairman, ask questions of the consultant and present rebuttal information and views, as provided in paragraphs (c) and (d) of this section except that written statements may be submitted to the Board with the consent of all participants.
(2) A participant may submit a request that the Board consult with a specific person who may have information or views relevant to the issues. The request will state why the person should be consulted and why the person's views cannot be furnished to the Board by means other than having FDA arrange for the person's appearance. The Board may, in its discretion, grant or deny the request.
(g) All hearings are to be transcribed. All hearings are open to the public, except that a hearing under § 10.20(j)(3) is closed to all persons except those persons making and participating in the presentation and Federal Government executive branch employees and special Government employees. At least a majority of Board members are to be present at every hearing. The executive sessions of a Board, during which a Board deliberates on the issues, are to be closed and are not transcribed. All members of the Board shall vote on the report of the Board.
(h) All legal questions are to be referred to the Chief counsel for FDA for resolution. The Chief Counsel's advice on any matter of procedure or legal authority is to be transmitted in writing and made a part of the record or presented in open session and transcribed.
(i) At the conclusion of all public hearings the Board will announce that the record is closed to receiving information. The Board will provide an opportunity for participants to submit written statements of their positions, with proposed findings and conclusions, and may in its discretion, provide an opportunity for participants to summarize their positions orally.
(j) The Board will prepare a decision on all issues. The decision is to include specific findings and references supporting and explaining the Board's conclusions, and a detailed statement of the reasoning on which the conclusions are based. Any member of the Board may file a separate report stating additional or dissenting views.
(a) The administrative record of a hearing before a Board consists of the following:
(1) All relevant
(2) All written submissions under § 13.20.
(3) The transcripts of all hearings of the Board.
(4) The initial decision of the Board.
(b) The record of the administrative proceeding is closed—
(1) Relevant to receiving information and data, at the time specified in § 13.30(i); and
(2) Relevant to pleadings, at the time specified in § 13.30(i) for filing a written statement of position with proposed findings and conclusions.
(c) The Board may, in its discretion, reopen the record to receive further evidence at any time before filing an initial decision.
(a) The availability for public examination and copying of each document which is a part of the administrative record of the hearing is governed by § 10.20(j). Each document available for public examination or copying is placed on public display in the office of the Division of Dockets Management promptly upon receipt in that office.
(b) Lists of nominees and comments submitted on them under § 13.10(b)(3) are not subject to disclosure unless they become an issue in a court proceeding.
The administrative record of the hearing specified in § 13.40(a) constitutes the exclusive record for decision.


text:
What should I eat? What is exercise? What should I know to stay healthy and strong? Enter the enchanted world of Playnormous to find out. There's an interactive story unfolding, and YOU play a starring role.
We call this, FunForAChangeTM. It doesn't matter if you're a kid, parent, teacher or health researcher. Fun never tasted this good!
Join us for an adventure of a lifetime. Sign up for free.
Welcome To Playnormous!
Read any good games lately? Your Playnormous story begins here.
Don't let the kids have all the fun! We built Playnormous for families. Check out our parents section for your role in health game adventures.
Teachers all over the country are using Playnormous as learning tools for K-5 students. Click on our teachers section for free teacher health guides, health classroom activities, student quizzes, and downloadable health posters. Please share what you learn with us. We may publish your class as a case study example!
Interested in using health games to prevent and treat childhood obesity? So are we. Let's work together! We've collaborated on more than $20 million of National Institutes of Health grants developing behavior change interactive technology. We have clinical trial data and proven results. Contact us about using our experience in your next research project.
Help us pick this week's Beast in Show by visiting the Monster Gallery. Make your own monster now. It's FREE!
Playnormous health games now on CD-ROM! Includes kid and teacher favorites like Pyramid Pile Up and Lunch Crunch.


text:
Osaka fashion: Namba and its independent spirit
Lee Jay Walker
Modern Tokyo Times
The magic of the Kansai region is the huge diversity which can be found throughout this part of Japan. This applies to the high octane nature of Osaka with huge skyscrapers, buzzing fashion and a city which is a powerhouse in its own right. Alternatively, you have the high culture of Nara within a short distance of time and for visitors to Kansai or locals who like to travel; then you are clearly spoilt for choice.
Osaka is full of life and in Namba you can feel the vibrancy of Osaka culture and this applies to fashion, entertainment and manzai. I often find aspects of Tokyo life easy because the comfort zone reality applies but in Namba you can feel a real "edge" and "vibrancy" which is hard to find in Tokyo.
Namba also ticks for 24 hours and the night time aspect of Namba applies to the sexual nature of the Dotonbori area and other forms of entertainment where people can unwind and forget about the seriousness of life.
During the day Namba is awash with different types of activities and the fashion scene is extremely vibrant. Added to this is manzai which is a unique comedy style and the famous Yoshimotokougyo School is located in this part of Osaka. Therefore, you will often see many young students practicing outside in one part of Namba and it is refreshing to see the younger generation so happy and not worrying about what others think.
Fashion is also buzzing and Namba ladies have their own distinct fashion and style. This also applies to the different thought pattern because the confidence factor and more outgoing style seems more natural. Often in Tokyo, you can feel a more timid way of life outside certain notorious areas but Osaka culture on the whole is more open and energetic.
In Namba you have trendy and fashionable areas like Amerikamura and Shinsaibashi Shopping Arcade. Also, electronic areas and manga can be found and Nipponbashi Den Den Town is popular. Meanwhile, the Dotonbori district is famous for entertainment and the innocence and vibrancy of manzai can be felt alongside trendy fashion areas and the seedier nature of nighttime.
This part of Osaka is also blessed with a nice waterway system and it is a nice place to relax and sit out and you will see many tourist boats on busy days. This also latches on to the genuine buzz of Namba. Therefore, even if you are by yourself you feel that you belong because of the ambient atmosphere.
Fashion in the Shinsaibashi Shopping Arcade and adjacent area surrounding this shopping complex is awash with fashion stores and you have a huge choice. Also, true to the nature of Namba, it is also a fusion of trendy boutiques with an independent spirit alongside well-known chain retail stores.
Fashion is really fascinating in Namba because of the options which are available. This applies to the high fashion of expensive department stores and influential brands alongside trendy boutiques which have a more independent feel. The combination compliments each other and for this reason you will see many different styles and the more you venture, then the more you will see the alternative side of fashion in Namba.
In the area called Amerikamura you have a reported 3,000 shops to pick from and the choice is really diverse and clearly you need time out to wander and find stores which have that special feel which each individual person is looking for. The youthful nature and buzz of this part of Osaka can be felt and domestic boutiques like Urban Research, Ships, Anna Sui, Stussy, and countless others, can be found in this vibrant and fashionable area.
Other places to visit in Namba are Namba Parks, National Bunraku Theater, Hozenji Yokocho Alley, Kuromon Ichiba Market (Emmeiji Market) and Kamigata Ukiyoe Museum. Also, for pure energy then the Dotonbori area is a must and it is nice to relax along the river and this applies to shopping, entertainment and many food outlets.
At night Dotonbori changes because the area is awash with stunning ladies and a different Namba comes into being during the night time and early hours of the morning.
Overall, Namba is a must place to visit in Osaka because of fantastic fashion and the natural raw energy which can be felt.
Osaka certainly is not in the shadow of any other major city in the world because it is a huge and highly developed city. Osaka is extremely vibrant and in Namba you will feel the raw energy and atmosphere of a place which is alive at all times during the day.
http://www.infomapjapan.com/sight_Namba.phtml (Info about Namba)
http://www.osaka-info.jp/en/search/detail/shopping_5160.html (Namba Walk info)
photo from http://www.flickr.com


text:
Restaurant by Kris Lin
Kris Lin Designs The Haneda Japanese Restaurant Restaurant
Kris Lin, the lead designer of the highlighted design Haneda Japanese Restaurant - Restaurant by Kris Lin explains, In a perfect dining experience, the most important thing is exquisite cuisine, also can match the soul-level feeling of space.The perfect combination of visison and taste, is the best experience. Pursue a feeling of [quietness] in overall design, make use of the performance on texture of concrete, expect to create a kind of introverted and calm feeling. A piece of natural rude stone is placed at the entrance, the water is flowing quietly in the gap of the rude stone, representing the vitality of [active in slience]. Many iron crafts are designed to make room have more extensive levels. .
Restaurant by Kris Lin Images:
End of the article, click here to go back to previous page, or alternatively go back to Meet Design Magazine homepage.


text:
Java doesn't have first-class functions or closures, but you can emulate some of that with anonymous classes. Alas, they are just too cumbersome and verbose—it's not elegant anymore if you need more LoC than with the iterative loop.
Recently at work, I wanted to execute some code for each member of a List, and I needed to know which iteration step I was at. A straightforward solution is, obviously, the classic for loop:
for (int i = 0; i < keyword.getSynonyms(); i++) {
String synonym = keyword.getSynonyms().get(i);
// do something
That's fine in many cases, but it has two problems. The extra line to get at the List element is annoying. More importantly, depending on the List implementation the
get(i) operation might be in O(n), requiring another scan of the list each time.
So we could iterate normally and count ourselves:
int order = 0;
for (String synonym : keyword.getSynonyms())
// do something
It's better, but I needed several such loops, and I wondered if I couldn't write all that plumbing just once. I came up with this:
public abstract class Counting<T, E extends Throwable>
public void loop(Iterable<T> things) throws E
int step = 0;
for (T t : things)
iteration(t, step);
public abstract void iteration(T thing, int step) throws E;
As the loop body can throw exceptions, and we might want to declare the specific kind of exception, this needs to be an additional generic type. This breaks if you need more than one exception type.
The above loop then becomes
new Counting<String, SQLException>()
@Override public void iteration(String synonym, int step)
throws SQLException
// do something
}.loop( keyword.getSynonyms() );
Hmmm. Even after writing an abstract class to extract the repeated parts, and not counting my preference for opening-brace-on-new-line, I still haven't saved a single line. Can I have
map and first-class functions, please? Time for Scala?


text:
Tim Tebow Traded to Jets for Draft Picks
Tim Tebow was traded from the Denver Broncos to the New York Jets for draft picks Wednesday, according to reports.
Tebow was traded to the Jets for their fourth- and sixth- round draft picks for next season, while New York gained a seventh-round pick in addition to the quarterback, according to Fox Sports. Curiously, the Jets seemingly acquired Tebow only as a complimentary backup player to starting quarterback Mark Sanchez.
"I'm sure he was disappointed," John Elway told reporters Tuesday, after calling Tebow the previous night to discuss the possibility of a trade. "He didn't come out and say he was disappointed. I think it was a typical Tim Tebow response in the fact that he was very positive, and he said, 'Well, we're talking about Peyton Manning, and I understand exactly what you're doing."
Sanchez, who was granted a contract extension to the tune of $40.5 million several weeks ago, will continue to start for the Jets, along with backups Drew Stanton, Greg McElroy, and now, Tim Tebow.
Tebow was replaced by Peyton Manning, formerly of the Indianapolis Colts, with a 5-year, $96 million contract. Only a week after he was released by the Colts, Manning had ousted Tebow from his starting spot, despite the sophomore bringing the Broncos to the playoffs from a 1-4 losing season.
"It would be our goal to get him in the best situation possible for him to have success also," Elway told The Associated Press before the trade. But was the trade to the Jets Tebow's "best situation possible"?
The Jets' new team dynamic could be affected substantially by the trade, with Tebowmania and Jets' locker room sentiment clashing.
"We don't need Tebow," tweeted Jets cornerback Antonio Cromartie before the trade, showing his allegiance to Sanchez. Cromartie's loyalty is strengthened by Sanchez's superior record when compared to Tebow- statistically, he's better, completing 55.3 percent of passes to Tebow's 46 percent.
However, Tebow made it to the playoffs through a number of harrowing fourth-quarter comebacks, something Sanchez failed to pull off last season. In addition, Tebow's fans- known for their love of the NFL player's public and devout Christian faith- could put pressure on Sanchez, possibly hindering his performance.


text:
Please send your message using the form below and we will contact by return as soon as possible.
Domain Brokers is a digital asset investment and brokerage service for domain only and website business sales.
We specialise in the acquisition and brokerage of premium domain names, providing a safe and secure full service solution for our clients world wide.
All domains are available for immediate purchase and transfer.
Goldstar Enterprises Limited
© All Rights Reserved
Home |
Browse All Domains For Sale |
Sell Your Domain |
Contact Domain Brokers |
Help & Support |
About Domain Brokers |
Instagram |
Website Design by Network22 |
Inventory Management Platform by Intersoft


text:
4-Channel high–performance USB oscilloscope 250 MHz bandwidth, 5 GS/s real-time sampling and 50 GS/s repetitive sampling.256 M/Sample buffer size.Built-in function generator.
4 x oscilloscope probes (x1/x10) and carry case included.
High bandwidth, high sampling rateWith the choice of either a 250 MHz, 350 MHz or 500 MHz analog bandwidth complemented by a real–time sampling rate of 5 GS/s, your PicoScope 6000 Series scope can display single–shot pulses with 200 ps time resolution. ETS mode boosts the maximum sampling rate even further, allowing a more detailed display of repetitive pulses.
Huge buffer memoryThe PicoScope 6000 Series gives you the deepest buffer memory available as standard on any oscilloscope at any price. The SuperSpeed USB 3.0 interface and hardware acceleration ensures that the display is smooth and responsive even with long captures. Other oscilloscopes have high maximum sampling rates, but without deep memory they cannot sustain these rates on long timebases. The 2-gigasample buffer on the PicoScope 6404D can hold two 200 ms captures at the maximum sampling rate of 5GS/s. To help manage all this data, PicoScope can zoom up to 100 million times using a choice of two zoom methods. There are zoom buttons as well as an overview window that lets you zoom and reposition the display by simply dragging with the mouse.
Advanced triggersAs well as the standard range of triggers found on most oscilloscopes, your PicoScope 6000 Series scope has a built–in set of advanced triggers to help you capture the data you need.
Custom probe settingsThe custom probes feature allows you to correct for gain, attenuation, offsets and nonlinearities in special probes, or to convert to different units of measurement. You can save definitions to disk for later use. Definitions for standard Pico–supplied probes are included.
Rapid triggeringThe PicoScope 6000 Series has high–speed circuitry that can trigger on and capture over one million waveforms a second, increasing your chances of spotting an infrequent glitch.
High–speed data acquisitionThe drivers and software development kit (SDK) supplied allow you to write your own software or interface to popular third–party software packages. If the 1 gigasample record length isn't enough, the drivers support data streaming, a mode that captures gap–free continuous data through the USB port directly to the PC's RAM or hard disk at a maximum rate of <10 MS/s (PC–dependent).
Ultimate performance, ultimate value for moneyWith 4 channels, up to 500 MHz bandwidth, 5 GS/s real–time sampling and up to 1 GS memory, the PicoScope 6000 Series are the ultimate USB oscilloscopes.A quantum leap in PC–based test equipment, the PicoScope 6000 Series give you world–beating performance together with all the features you would expect from a PicoScope oscilloscope. And — unlike other manufacturers — all features are included as standard (when new features are added you simply need to download a free copy of the software).
If you want the ultimate performance and the ultimate value for money, you want a PicoScope 6000 Series oscilloscope.
Documents available for download: PicoScope 6000 data sheet
*Quoted bandwidth is with supplied probes or at BNC when 50 Ω impedance selected