text:
Health in Diagrams III -- Inflammation from Cell to Tissue
Saturday, March 15, 2014
Health Diagrams II — Curing Autoimmunity and Allergies
Health in Diagrams III -- Inflammation from Cell to Tissue
90 comments:
- Unknown said...
Hi Art,
Before I ask a quick question, I would just like to thank you for the contributions you make on your blog. I have only been coming here for little under a month, but already I have learnt a lot of very valuable information. You seem to be a humble individual, too, despite your obvious brilliant intellect, so please accept my sincere gratitude for sharing your thoughts.
As for my question, it is related to garlic.
What effect does garlic, or more specifically, allicin, have on gut flora?
I occasionally take Aged-Garlic extracts (supplement) as a general tonic.
Can you inform me if I'm inadvertently harming my microbiome?
Many thanks,
- March 15, 2014 at 2:41 PM
- Tim Steele said...
Art - Really great description of T cells and their functions. This is one of the first readable explanations I've seen. This is such a confusing, yet important aspect of RS but it puts most people to sleep.
The very first study I read on RS was done on pigs and described the healthier Peyer's Patches and turning of naive T Cells into Tregs. At the time, it didn't mean anything to me, but now I go back and see that was maybe the most important discovery at the time.
The BG regulation, satiety, and sleep improvements are great (and noticeable), but the effects of butyrate in an SCFA-starved gut on the immune system are largely unnoticeable but one of its greatest contributions to our health.
- March 15, 2014 at 3:23 PM
- Raj said...
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- March 15, 2014 at 3:49 PM
- James said...
So Art, if I read you well mother's milk would do the trick? In other words a market for it? Could be fermented?
- March 15, 2014 at 4:01 PM
- Dr. Art Ayers said...
Garlic, like all plants, are antibacterial and provide soluble fiber. Your gut flora can adjust to both. Plants are also naturally toxic, so don't eat too much of any type.
Thanks for your kind comments.
- March 15, 2014 at 5:29 PM
- Dr. Art Ayers said...
I used to teach immunology, so I am a little embarrassed by some of the short cuts in the explanation. I think it is still basically true.
Thanks for watching.
- March 15, 2014 at 5:33 PM
- Dr. Art Ayers said...
Hi Raj,
The husk is just another soluble fiber and it can be digested by the appropriate gut flora, but it is based on a sugar other than glucose. You apparently have the right gut flora.
It is interesting to ponder the social ramifications of diet and health.
I think that most of the human body is continually replaced, so unless there is severe structural damage most of the symptoms of disease are reversible.
You should be able to clean out the gut and start from scratch with new bacteria and result in a rejuvenated immune system. That happens with bone marrow transplants and autoimmune diseases, e.g. T1 diabetes, are cured. Impact on the nervous system may be more recalcitrant.
Thanks, as always.
- March 15, 2014 at 5:41 PM
- Dr. Art Ayers said...
All of the mother's milk should be reserved for babies and be supplemented from milk banks in hospitals, if there is a medical reason. Formula should be excluded, because it has permanent negative impact on gut flora and subsequent health. Special care should be taken in all medical settings requiring antibiotics to fully repair gut flora damage. Dairy probiotics are not adequate and are misleading.
Thanks for your questions.
- March 15, 2014 at 5:48 PM
Dr. Ayers,
You seem to be saying type 1 diabetes can be cured. I am skeptical, but hopeful, as my son has type 1. (We adopted him as a baby, and had been on soy formula, which we continued until he turned one.)
I've been reading your blog for years, and am grateful to you for sharing your knowledge.
- March 15, 2014 at 7:42 PM
- David said...
This is fascinating Dr. Ayers!
Can I get your opinion on the state of my little gut friends? ME/CFS, elevated antibodies for many bacteria and virus, chronic constipation with Bristol 1, bloated/tight feeling at cecum.
Started VSL3, Prescript-Assist and had awesome Bristol 4 BMs for 2.5 months. Added PS and psyllium shortly after the probiotics. Still good.
But at that 2.5 month mark I started having the Bristol 1 and constipation again. Like somebody flipped a switch. Stool test from shortly after starting the probiotics shows low but in range commensal bacteria, low pH, Campylobacter.
I've tried variations of the probiotics and RS to no avail.
Anything I'm missing?
- March 15, 2014 at 7:43 PM
- Raj said...
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- March 15, 2014 at 7:44 PM
- mfairchild said...
Dr. Ayers,
Thank you for this series. I'm on the autoimmune attack side of the equation and just had my third dose of Probiotic-3. I have everything else in place: diet, ferments and RS. I have my fingers crossed!
If Clostridium butyricum is the keystone gut bug to enhance Treggs and thus balance the immune system from autoimmune attacks, what species is missing on the other half of the equation if a person has frequent illnesses and cancer? Is there a keystone species for that?
- March 16, 2014 at 8:26 AM
Hi Dr Ayers,
I too am on the autoimmune attack side of things with Hashimoto's developing into food sensitivities and a slow MMC with a SIBO diagnosis in November. I do a completely organic diet, gluten free, with RS and PS, as well a fermented foods. I can't digest raw veggies or high fodmap foods even when cooked. They cause more constipation, gas and fullness. I have been taking Prescript Assist for a while and a Custom Probiotics blend with pretty good results. This week I added AOR-P3 and seem to have itching skin areas and back to small amt of stool. I feel plugged up! Am I missing something to be able to benefit from the clostridium ? If I continue to take it with RS will it improve things over time? Are there any other sources of probiotics or SBOs that could help? Thanks for all of your great, informative posts. All of this truly helps so much!
- March 16, 2014 at 8:58 AM
- Unknown said...
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- March 16, 2014 at 9:06 AM
With regard to fermented veggies, how much should be eater per day?
I eat some kraut and pickles from Raw Pickles, a co-op in NE of organic fermented; they are naturally fermented.
- March 16, 2014 at 11:44 AM
Some sources suggest that Clostridium butyricum can produce botulinum toxin just like Clostridium botulinum and thus cause botulism ... What about that ??
- March 16, 2014 at 1:35 PM
- Lola said...
Thank you so much for all of this information. I'm starting everything right away. I'll let you know how it goes.
- March 16, 2014 at 2:57 PM
Dr. Ayers, Have you heard of fluoroquinolone antibiotic toxicity? I have been completely disabled for over six years now since the age of 21 after 12 days of Levaquin. Now at 27 I am still deteriorating and feel like I don't have much time left. All I eat are grassfed meats, organic steamed veggies and water. I react to almost everything and especially have major reactions to probiotics. My CNS goes wild whenever I eat and I am suffering from severe malnutrition as a result. I was hoping you could help me or give me some idea as to what you think I can do. I suspect that I have not been able to make adequate stomach acid/enzymes as a result of being ruined by levaquin, but I would love to speak to you via email if you wouldn't mind listening to a quick version of my story/symptoms. I so appreciate your blog, and find it so informative and interesting, I am just at a loss for what to do since I react to everything and anything. My email is firstname.lastname@example.com.
- March 16, 2014 at 3:38 PM
- Ashwin said...
Dr Art, Thank you for a most interesting and informative article. I have a question for you. What are your thoughts on the new thinking behind the function of the Human Appendix? There are some who believe that the appendix is a storage vesicle for the Human gut Microbiota and that this store is used to re-populate the GI tract after damage to the microflora as is caused after a course of wide spectrum Antibiotics. This may suggest that all you need is appropriate food source for the microflora, as in prebiotics, Resistant Starch, etc. What are your thoughts?
- March 16, 2014 at 4:22 PM
- Ted said...
It's unfortunate that Dr. Ayer's posts always get flooded with commentators seeking medical advice. It'd be nice if we can discuss the science, not personal questions that are better suited for a medical clinic.
- March 16, 2014 at 10:37 PM
- Puddleg said...
Excellent post Art!
In humans, Treg differentiation requires retinol derivatives. vitamin A deficiency possibly a factor in development of autoimmunity (retinoids are common pharmacological treatments for autoimmune conditions).
Some pathogens trick Tregs into working to "mask" their presence. This co-opted immune tolerance helps a virus like HCV become chronic, but because it suppresses inflammation, can also make it possible for some people to survive long-term infection with little damage.
Tim, it is probably not the butyrate converting the Treg, so much as direct contact with the bacteria itself. The bacteria is somehow able to identify itself as "friend", and the general message, conveyed from the Peyer's patches, that friends outnumber enemies, puts the immune system into a more relaxed state. The butyrate being anti-inflammatory at a metabolic level no doubt re-inforces this.
You are right about how confusing it is. To study Tregs you need a kaleidoscope, not a microscope.
- March 17, 2014 at 12:00 AM
Dr. Ayers,
Really enjoying and learning from your posts. Keep 'em coming!
Q: As far as plant matter goes, I want to be clear on your position...
You seem to be saying they are a necessary evil. That the fiber is the part you want and NOT the juice or the meat since these contain the pants antibiotics.
You also seem to be saying fermented veggies are best.
I would LOVE for you to do a post dedicated to the bottom line on plant matter for human health.
- March 17, 2014 at 8:24 AM
Ted, the reason Dr. Art gets so many medical questions is that there are many desperate people out there who are getting little or no help from the medical community. In answering the questions, Dr. Art is helping not only the questioner, but also the dozens of us out there who have the same question.
If it were my choice, I would confer sainthood on Dr. Art for the help he is giving to those of us who are functional illiterates when it comes to science and biology but who need help on our journey to restoring health.
- March 17, 2014 at 9:01 AM
What is the bst way, short of fecal transplants from a healthy donor, do you replenish a gut flora damaged by several courses of antibiotics?
- March 17, 2014 at 9:30 AM
- Raj said...
- This comment has been removed by the author.
- March 17, 2014 at 11:21 AM
- antonio sabarro jr said...
Just wanted to thank Dr Ayers for another great post, this blog has been a life saver for many of us suffering from autoimmunity. For people gearing up to grow their own vegetables this year for fermenting and soil-based organisms I definitely recommend the book TEAMING WITH MICROBES. Also been having some success with consuming raw maple sap as a natural probiotic if you have access to it.
- March 17, 2014 at 3:45 PM
Hi Dr. Ayers,
What are your thoughts on people receiving fecal transplants that haven't been cured autoimmunity? My thoughts are it could be incompatible/not healthy enough gut flora from the donor or not enough transplants, but I'm interested to know your thoughts. I have actually had one done via colonoscope, and I did some supplemental ones on my own, but unfortunately, it didn't seem to help my Crohn's colitis. I've also read conflicting studies on fecal transplants for others with IBD, some it helped and some not, so I wonder what we need to factor in to these cases.
Also, as far as breastfeeding goes, do you know if the mother has an autoimmune disease if it somehow compromises her breastmilk or the benefit of the breastmilk to the baby?
Thank you for your contributions on your blog. It's encouraging to see people use their knowledge and background to help promote health and reverse autoimmunity.
- March 17, 2014 at 4:02 PM
Also to Ted:
What is the point of doing the science if it can't be applied practically? In this case the application is in helping people achieve greater health, ya?
- March 17, 2014 at 6:45 PM
- John said...
Kor and others,
Ted is right. This isn't the place to list all your symptoms and ask for a diagnoses and treatment plan from Art. That should be obvious. Also, he has several years of posts. Everyone should be able to read though and generalize for themselves. Then go to a medical professional and discuss.
- March 17, 2014 at 10:55 PM
- Ted said...
john, +1, exactly my point :)
- March 18, 2014 at 5:48 AM
- Unknown said...
I always enjoy and look forward to your posts.
You mention Clostridium as an important keystone species for proper immune function. Are there any other "honorable mentions" or otherwise important species that play a critical role in immune/digestive health?
Thank you,
- March 18, 2014 at 9:58 AM
Dr. Ayers,
Thanks from a first time poster, long time reader.
You advise us to avoid anti-biotics. Does this include food sources such as garlic which is purported to have antibacterial activities?
- March 19, 2014 at 1:25 PM
When you speak to curing allergies are you including airborne allergies: hayfever, pollen, ragweed,etc?
There are immune cells in the skin
- March 19, 2014 at 3:27 PM
In reply to Dan Reese,
The following study suggests that the probiotic, bifidobacterium infantis is likely helpful in this area also.
I believe this is the active component in the probitic called Align. I've seen this in most larger chain drug stores/pharmacies.
- March 19, 2014 at 5:26 PM
Dr. Art,
I was watching this video where Dr. Wayne Hancock is discussing how they are exploring the possibility of limiting or reducing tregs in an attempt to fight cancer. By limiting or reducing tregs, they are hoping that the body will better be able to mount a full immune system attack of existing cancer in the body without the tregs mobilizing to limit this immune response. Assuming I understood him correctly, my question is, if a person happened to have cancer, but was not aware of it and started taking RS to increase treg cell production, could this lead to the cancer more freely multiplying?
Thank You.
- March 21, 2014 at 5:26 PM
- Dr. Art Ayers said...
I think that you are correct. Cancers go to a lot of effort to stimulate Tregs.
Most people have antibiotic and processed food damage to their gut flora. My impression is that leads to greater deficiency of Tregs and more autoimmune disease than cancers. Further damage may produce infectious disease susceptibility and cancer as well. This may be the immunocompromised people who get food poisoning.
There are a lot of people who are so dysbiotic that they are intolerant to everything including probiotics and soluble fiber. We need an approach to construct the gut flora from scratch with common sources of bacteria. With the exception of fecal transplants, I don't think it is being researched. It could be very cheap and would cost the medical industry billions in profits.
Thanks for the comments/questions.
- March 21, 2014 at 5:53 PM
Dr. Art,
Thank you for the reply.
It would certainly be great to be able to fix many of our common ills with something possibly as simple as a specific bacteria appropriate enema or suppository!
I guess that would be too simple, easy or inexpensive to ever think it could realy become common practice though, or could it.
- March 21, 2014 at 11:32 PM
If one important aspect of taking RS is to increase or protect treg cells in the colon to help control chronic inflammation there, then folate / folic acid may be a possible supplement to consider as part of the regimen if the following study is correct.
- March 22, 2014 at 12:21 AM
- Unknown said...
Re: folic acid that's pretty interesting and corroborates the above comments on cancer and what Chris Kresser says about the supplement - that it increases cancer risk.
"One of the major risks associated with excessive intake of folic acid is the development of cancer..." (Sources cited in his post)
Like you said, it's about finding immune system balance.
- March 22, 2014 at 6:52 PM
Hi Dr. Ayers,
A commenter posted this question to you, "if a person happened to have cancer, but was not aware of it and started taking RS to increase treg cell production, could this lead to the cancer more freely multiplying?"
And you replied that you thought it was correct. I have gone back to read all your posts on Tregs. And am thoroughly confused.
So by adding RS to my diet along with with fermented food, a non inflammatory diet (no processed food, no gluten and sugar) and and a probiotic containing Colistridium B. I am helping my body rid itself of my autoimmune disease but may be feeding cancer to multiply more freely if present?
From a confirmed "fermentista"
- March 23, 2014 at 6:48 AM
- Unknown said...
Mary Beth, I am right there with you! Dr. Ayers really shifted the ground under my feet last night when I read the comment about RS being good for auto immune but tricky for cancer? I am a early stage (no chemo) BC survivor since 2009 and since then have been reading as much as possible to do all that I can to avoid a relapse. I am not trained in medicine so the going is slow. But about 4 months ago I found 'Cooling Inflammation' and all the pieces began to fall into place. Most of the sites I read were above the microbiota level. As someone said, 'everyone forgets the biome'. I have spent hours and hours researching my various snps including MTHFR. I had finally come to the realization that all the expressions of the SNPs would fade into the background, if I fed my gut right. But now, if I am interpreting Dr. Ayers correctly, what may be good for some bacteria that control auto immune diseases arising, may be bad for the bugs that control the rise of cancer? Please Dr. Ayers, expand on this. Which bugs should I concentrate on with what substrate, if Clostridium and RS are not the ones for cancer protection?
- March 23, 2014 at 7:09 AM
- Dr. Art Ayers said...
MaryBeth and Sally,
I don,t worry at all about increasing cancer risk by fixing suppressive immunity and Tregs, any more than I worry about getting infections when I avoid eating inflammatory food, as I see it, our bodies have robust defenses over a broad range and it is only the crazy extremes that get us in trouble. Antibiotics, sugar, vegetable oils and foods lacking soluble fiber are outside that range. That is also why paleo diets and unprocessed food are in the range.
In the crazy periphery, all of your genetic uniqueness will be problematic, but anywhere within the reasonable is carefree. Antibiotics quickly lead to the crazy extremes promoting autoimmunity or cancer, and more antibiotics are frequently used as therapy to remove the remaining half. Little research has been done on how to repair severe gut dysbiosis, although this is the most important part of a cure for most diseases. Chronic disease and therapy is much, much more profitable. My simple website costs the medical industry hundreds of thousands of dollars each year.
The bottom line is that I think fixing any part of the gut flora and immune system is a good thing. Most problems are reversible. The optimal strategy for each person toward a healthy gut flora and immune system is empirical right now. There are some reasonable combinations of probiotics, soluble fiber and fermented veggies that are available at sites such as Animal Pharm and Free the Animal.
Keeping asking questions if you think I can be helpful. Let me know how you are doing.
- March 23, 2014 at 12:19 PM
Dr. Art,
To be a more direct regarding RS, clostridium, soil based probiotics and cancer, if a person knows they currently have some form of cancer, would it still be advisable to use the RS, clostridium and soil based probiotics for their potential to repair the broken gut biome or should they be avoided as long as the cancer is present?
Thank you.
- March 24, 2014 at 2:08 AM
- Unknown said...
Hi Art,
You might want to check out FTA. I cross posted the question I asked Dr. Ayers over there and got responses similar to Dr. Ayers but more specific to your question. If you look in the comments section of 'How Eating Heaps of Safe Starches Cured My Diabetes' you will see my comment and several very good responses.
- March 24, 2014 at 9:01 AM
- Unknown said...
Dr. Ayers,
I wanted to thank you for your response to my question regarding BC and RS. I'm sure I'm not alone when I say that sites like yours give so much hope to people who have been through western medicine's ringer. Your generous nature is very much appreciated. I am doing much better now and read your blog as well as the others you mentioned in my continuing journey of gut repair and health optimization.
- March 24, 2014 at 9:34 AM
Thanks Sally!That was my next stop as I have been following FTA and Animal Pharm since January 2014.
Mary Beth
- March 24, 2014 at 9:41 AM
Dr. Ayers,
I too am grateful for your response to my question and the time you devote to sharing your research on inflammation etc. I am by no means out of the woods right now, but believe I am on the right road.
Thanks again!
Mary Beth
- March 24, 2014 at 11:33 AM
- Unknown said...
Hey Dr. Ayers,
What are your thoughts on this research that (if I understood it correctly) claims T-reg cells can be inflammatory
"In patients with psoriasis, Tregs readily turn into IL-17-expressing cells, thus potentially perpetuating the inflammatory process that characterizes the disease."
I just started implementing this protocol, and am curious about your interpretation of this research!
Thanks for all you do,
- March 24, 2014 at 1:59 PM
- Hormone Fairy said...
I am very confused. Can you clarify for me? I have infertility most likely due from an autoimmune disorder. My doctor things that I have low grade viruses in me, stemming from working in the health care industry. He thinks that the egg is being attacked by my immune system and not letting it to implant, most likely from my immune system being overactive.
I eat fairly good, and recently started a gluten free, lactose free, egg free and starch free diet. I have been taking probiotics with 14 strains and SBO on and off. I consider my gut fairly healthy. Would you recommend that I DO take probiotics or DO NOT take probiotics to down regulate my immune system, and do you recommend the SBO probiotics?
- April 13, 2014 at 12:22 AM
I was wondering if you have any suggestions for dealing with menopause related recurrent urinary tract infections? My understanding is that lack of estrogen and vaginal atrophy cause e-coli to overgrow in the urinary tract. I've tried D-Mannose and am on the third course of antibiotic treatment since the fall. Very upsetting. Oral probiotics don't seem to work either; I found a very expensive vaginal probiotic containing several strains of lactobacillus, but I'm not sure that will work either - and at $50 for 6 it isn't feasible to use daily. I eat tons of fermented vegetables and take probiotics. I can't find any information on this important topic. Many post menopausal women suffer from recurrent UTIs. I don't want to take an estrogen supplement. If you have any insights or thoughts on this I'd be so grateful to hear them. Thanks so much.
- April 15, 2014 at 7:21 PM
- Unknown said...
- This comment has been removed by the author.
- April 16, 2014 at 6:33 AM
- Unknown said...
I use a mix of supplements: grapefruit seed extract, D-mannose, cranberry, UTI Support by Designs for Health, empty bladder before and after, cleanse, drink a lot of water, and take the above supplements. Also, I supplement with resistance starch (see Dr. Ayer's post on potato starch and resistant starch or 'Free the Animal' posts on RS). I'm hoping the supplements taken 3x day of, the RS+probiotics, and the regime is working. I had two UTI's in 4 months and started this protocol about 2 months ago, Not very romantic but cautiously optimistic that I may be able to avoid infections this way. Also, Dr. Art answered a question I had about this not too long ago: http://coolinginflammation.blogspot.com/2014/03/health-diagrams-iii-inflammation-from.html?showComment=1395692587981#c2130982744238588005
- April 16, 2014 at 7:00 AM
- Hormone Fairy said...
I own a compounding pharmacy. We sell probiotic vaginal capsules for $1.50 each so well worth it. It has worked well for many of my patients. Sometimes, replacing the vaginal estrogen with estriol vaginal cream will replenish the cells and prevent recurrent UTI's also. I have also seen some Dr's prescribe Boric Acid 600mg vaginal suppositories too.
- April 17, 2014 at 11:03 PM
- Kristina said...
Thank you for this post and all the time and effort you put into providing information for folks.
Was wondering if you recommend RS and/or Probiotic-3 if SIBO is an issue.
Thank you,
- April 22, 2014 at 7:34 AM
Thanks Hormone Fairy and Sally.
- May 1, 2014 at 8:35 PM
I have an interesting observation (n=1) regarding the psoriasis - cancer connection mentioned earlier by commenter Cooper Mor.
An older relative became, relatively suddenly, sick in psoriatic arthritis. She had never before had an autoimmune disease. About a year later, she passed away in advanced stage pancreatic cancer.
I have tried to understand if there could be a connection. From the info I found here, this seems to be the connection: The cancer stimulated the Tregs, which later turned into IL-17-expressing cells.
Thus, an autoimmune disease as a symptom of cancer.
- October 27, 2014 at 12:44 PM
- Aaron Kaskowitz said...
My uBiome results showed lower than average Clostridium. I was about 2.34% and healthy omnivores' data had over 3%. Do you think this is likely a contributing factor to my Multiple Sclerosis?
Should I focus on that and try to fix it by taking potato starch and AOR-Probiotic 3?
Any suggestions or more information that I should follow regarding MS would be VERY welcome. Thanks!
- October 27, 2014 at 1:00 PM
- Professor Lars said...
Random musings -
(partly an unasked-for answer to Aaron):
Microbiome measurements seem to be inherently imprecise.
Perhaps it's a good idea to send in the p**p to several different places.
Speculation: Home-grown, unwashed, vegetables probably contain the bacteria we need to populate our guts with. No need for pills. One example: there exist oxalate-digesting gut bacteria. They will save you from a certain type of kidney stones (calcium oxalate - people who get those tend to get them repeatedly).
Where might one obtain those bacteria? On the leaves of oxalate containing vegetables, of course. Unless those leaves were first soaked in various herbi- and pesticides and then washed.
Conclusion: make sure you have access to a wide variety of unwashed, purely organically grown vegetables.
- October 27, 2014 at 2:17 PM
- Professor Lars said...
Dr. Wahl's protocol seems quite popular with MS patients. It's a very nutrient dense paleo eating style.
- October 27, 2014 at 2:32 PM
- Aaron Kaskowitz said...
I also had EXTREMELY low prevotella - .34% compared to a uBiome healthy omnivores' sample average of 7%. Perhaps this is related.
- October 28, 2014 at 1:23 PM
- van Nieuwstadt said...
Dear Prof. Ayers,
I found your blog not long ago and I am impressed by your knowledge and eagerness to help others. I think that you have the knowledge to help me with fighting inflammatory diseases that I suffer from (I would be extremely grateful for your advices):
a) Skin inflammation – my dermatologist says it's caused by a bacteria from staphylococcus family. This was the first one and the most problematic to me, I keep it under control but I am simply tired of doing this for around 15 years (I am 27 now). To cure the symptoms, I use a cream with erythromycin, triamcinolone and pasta zinci.
b) Sinuses inflammation – I always breathe through 1 and ½ hole because one hole is partially blocked. I love swimming but I have to stop it because it was causing an inflammation of my sinuses. The problems started in 2010, after deviated nasal septum surgery.
c) Colitis ulcerosa – autoimmune bowel disease. It developed in 2012 after having trauma after my father's death from bladder cancer. I managed to cure it by changing my diet to Paleo-like – I have no symptoms for the last 2 years.
d) Blepharitis – it developed in 2013/14, I do not use and medicaments to treat it, just have occasional eye inflammation, I noticed it's very related to sinuses and gets worse after swimming. If I don't swim for many consecutive weeks it seems to be completely gone (until next swimming trial).
How to treat all of these? My diet is clean from high-carb and junk food, absolutely no added sugar, in other words nothing that can increase inflammatory effect. I found your blog couple of weeks ago and decided to:
1) add fermented foods (pickles, Brussels sprouts, okra) and symbiotics in pills (are pills necessary?)
2) exclude dairy probiotic products (I used to eat high-fat Greek yoghurts and occasionally kefirs)
3) I temporarily excluded eggs because I found that they also may trigger inflammatory reaction (I implemented this one week ago, is it necessary in your opinion and if so, how long should it take to see if it works?)
On top of that I exercise every day to keep inflammation at bay and try to eat 2-3 gloves of garlic almost every day. I am in good overall shape: 183cm/80kg, athletic body.
Where is the key to win this battle? I know how being healthy feels like, because 2 years ago I had a treatment with minocycline and it had tremendously positive effect on all of diseases mentioned above – they were all gone for around 3 weeks. I never felt better in my live before. I wrote that because it may be a good indicator of what I should do to win the battle with all those diseases.
I would be very grateful if you could read my lengthy post and reply to it, I believe it may be helpful for other readers too.
(Apologies for all typos – I live in Europe and English is not my native tongue).
Best regards,
- June 5, 2015 at 8:16 AM
- Dr. Art Ayers said...
It seems to me that your problem is inflammation and immune system dysfunction all based on damaged gut bacteria. You have already started to address this with fermented vegetables and I hope you are making your own.
Inflammation, such as in your case, also suggests that your vitamin D production will be poor. Check your vitamin D levels, supplement as needed and check again. High levels of serum vitamin D usually decreases inflammation symptoms.
You should also be aware of omega-3 oils (excluding omega-6 vegetable oils) and prebiotic fiber.
Inflammatory responses to food usually indicates food intolerances that result from missing gut bacteria. Fix your gut flora and you will eliminate the food intolerances.
The dermatitis would not occur without damage to your immune system and the immune defects are based on missing gut bacteria.
All pharmaceuticals impact gut flora, so it is difficult to repair gut flora and take pharmaceuticals.
The reason that minocycline relieved your symptoms was that it killed off the gut bacteria responsible for the remaining part of your immune system. With a thoroughly compromised immune system, your aggressive immune attack symptoms were reduced.
People typically pick up new bacteria in their gut by constantly swallowing inhaled bacteria, or bacteria on the surface of fresh vegetables or from significant others. A friend of mine with significant inflammatory disease would go into remission every time he had a new girl friend. He probably would have also benefitted from an outdoor pet, gardening, tending a floor sweeping toddler or generally being less hygienic. Hygiene is typically an enemy of healthy gut flora.
I would suspect that swimming may also reduce your overall microbiome by killing off everything with chlorine and showering. Showers also reduced vitamin D uptake from solar exposed skin.
Also, note that one of the best treatments for sinus infections is humming.
Let me know how you progress.
- June 5, 2015 at 2:49 PM
- van Nieuwstadt said...
Many thanks for your reply prof. Ayers.
What do you think about medicaments such as fluconazole, which is supposed to treat fungal and Candida infections? It was not my idea, but my doctor's, and I remember I took it for couple of days/weeks, but with no noticeable improvement.
I studied the matter before and I am aware of importance of vitamins and minerals. My daily supplementation is multivitamin (chelated) and additionally 10.000 IU in a pill form if I am not exposed to the sun for at least 20 minutes over the course of the day.
Same with omega-3 oils, I eat considerable amount of fish almost every day (150-400g per day), plus I take 2x1000mg of fish oil (18% EPA, 12% DHA) per day.
What's your view on taking large doses of vitamin C in a form of ascorbic acid? I am considering adding this to my daily supplementation, though I do not have a problem with flu/fever – I haven't been sick in the winter for 12 years. But perhaps it is beneficial to repairing gut flora?
An interesting point is the link between being exposed to dirt and animals and gut flora, since I lived on a countryside until the age of 9, and my problems with dermatitis started when I was 13… I already heard about the hygiene theory, but now I am seriously considering implementing some 'dirt' changes to my life. What changes do you think are the most crucial here? When it comes to my skin, I have already learned that my eczema goes worse if I stopped using soap. The good news is that I managed to reduce my cosmetics to baby soap and no-fluoride toothpaste. No shampoo, no antiperspirants etc.
My current diet looks is the following:
- Breakfast: couple of fruits and vegetables (salad, celery, cucumber, apple, lemon) mixed in blender. I used to eat 5-6 boiled eggs with walnuts, but I stopped 10 days ago to check if it doesn't cause any inflammatory reaction. Do you think it's a good move?
- 2nd breakfast: banana
- Lunch: meat or fish with raw vegetables (usually beetroot, carrot, tomato, raddish)
- Dessert: apple and avocado (not regularly)
- Supper: meat or fish with grated 2-3 gloves of garlic, plus sauerkraut/pickles/okra.
- Extras: green tea, 1-2 pieces of dark chocolate (85% cocoa), aloe vera juice (2x60ml daily on empty stomach) and apple cider vinegar (2 tablespoons with a glass of water 1-2 times a day, before a meal). What do you think about having a glass of red, dry wine several times per week? I don't do it more for health reasons rather than pleasure (but ok, there is some pleasure in it too).
Thank you in advance for your comments, that's greatly appreciated. You've just gained a new faithful reader!
- June 10, 2015 at 9:18 AM
- Unknown said...
Hi This is fantastic information. I work with babies and see many with signs of immune function imbalance. I fully appreciate the benefit of breast milk on the immune system development however am seeing mothers who have compromised immune systems/gut flora and their babies are getting ill. My question is, apart from implementing the strategies you discuss into a breast feeding mothers diet, what is the best and safest treatment for formula fed babies from birth up until the introduction of solids? The concern being that their systems become overwhelmed with bacteria and it becomes a cause of disease instead of health?
- June 22, 2015 at 10:57 PM
- Evan said...
What is the software you used to create this infographic type diagram? Is it creately ?
- June 24, 2015 at 12:43 AM
This is in response to 'Professor Lars'' comment that one can find bacteria that break up oxalates on certain vegetables, provided they hadn't been washed or sterilized in some way.
Sorry, but that's not true from what I've read, because the bacteria that degrade oxalates are anaerobic.
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- August 6, 2016 at 2:00 AM
- JPOM said...
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- August 25, 2016 at 12:17 AM
Dear Prof Ayers,
I suffer from LTP allergy, or allergy to a protein, LTP, found in all plants. Many fruit and vegetables, herbs, nuts and seeds, the sacred foods that are supposed to nourish and heal us, actually make me ill. The allergy is confirmed by RAST test. I was wondering if you have an advice for me too :), something that can help lower my IgE or help me tolerate foods better perhaps. The symptoms are constant gastritis, bile reflux, and I am waaay underweight. The problem is I cannot avoid completely this LTP or my diet would be very unhealthy. My cabinets are full of digestive enzymes, amino acids and more, providing only a temporary relief. Thank you for your precious help- Angela R
- October 6, 2016 at 10:26 AM
- Dr. Art Ayers said...
Angela R, LTP allergy,
LTP is a lipid transfer protein that is related to the alpha amylase/trypsin inhibitor of wheat that causes celiac. You can see a post about it on my site. I would guess that an allergy to LTP is just the early stage of celiac, before it is converted to an antibody reaction to gluten and gut transglutaminase, before eventually attacking the thyroid.
The point here is that this is an autoimmune disease in the early stages, posing as an allergy. Autoimmune diseases and allergies all have an origin in gut dysbiosis/damaged glut flora that produces an immune system problem, defective immune tolerance mediated by regulatory T cells, Tregs. Tregs mature in the lining of the gut in response to gut flora, which means that your problem fundamentally is a lack of bacterial species in the gut needed to produce immune tolerance.
Vegetables are important nutritionally to supply prebiotic polysaccharides, e.g. resistant starch, inulin, pectin, used to feed specific gut bacteria to produce short chain fatty acids and other components to control development of immune cells in the gut. Without those immune cells, some of which suppress aggressive reactions, autoimmunity and allergies develop. That is your case.
My initial impression in summary, is that you have an early stage of celiac, probably precipitated by antibiotic killing of gut flora. You need to replace the missing bacteria, by somehow eating those bacteria. Many of the missing species are in the group of Clostridia, so most probiotics, thou temporarily of benefit in helping to develop the missing parts of your immune system, will not repair your gut flora. A few have C. butyrica, which may help.
In addition, you need to eat prebiotic polysaccharide fiber to feed your missing gut bacteria. It is clearly a good idea to not fan the flames of your LTP (ATI) allergy, so you would be wise to avoid whole veggies and stick to rendered soluble fiber, e.g. potato resistant starch, inulin and pectin. You might also be able to eat fermented vegetables, since the fermenting probiotic bacteria should have digested some of the problem. I would stay away from seeds and especially grains/wheat, since they are rich in ATI and you are heading toward gluten intolerance.
Let me know it this is a helpful explanation of your situation.
I would also guess that you already or will develop SIBO. Obviously, any drugs that you take will be a problem, since most have strong antibiotic activities that will exacerbate your problems.
How do you tolerate potatoes? The Potato Hack would be a good tool for gut repair, if you can tolerate it. You might also look into Probiotics-3.
- October 6, 2016 at 12:52 PM
Wow Professor Ayers, I've been studying LTP for 4 years now but this is all new information to me. Thank you, thank you so much. I never stop learning. My LTP allergy started during my teenage years but only got the worst symptoms after my pregnancy. A few months after giving birth, I gradually became allergic (IgE allergic) to every plant based food, with symptoms like diarrhea, heartburn, bile reflux and severe joint pains. A nightmare. I recently started an immune modulating therapy that allows me to tolerate foods better. Yes, I can tolerate potatoes and other root vegetables. I can now eat berries, lettuce, brown rice, coconut, mushrooms and others. I have to stay clear from peach and fruits of the peach family (apples, pears, cherries etc) as I had a severe reaction to Pru p3, the LTP of peach which cross reacts to many other LTPs. I am IgE positive to gluten too and I have not been eating gluten for the past 4 years. Dairy, even from goat products, despite not containing any LTP, is a struggle to digest and can trigger heartburn. I'm trying to heal my esophagus, inflamed after years of bile reflux, so I have to avoid that too. So you think that everything generated from gluten? That is most interesting to me. But my first reaction was to peach, was that generated from wheat allergy? And how come I'm not "cured" after years of avoiding gluten? I'll try Probiotics-3. What is the potato hack? I'm really trying hard to heal. Look forward to your comment. Angela
- October 6, 2016 at 3:05 PM
- Dr. Art Ayers said...
Most doctors don't keep up with the biomedical literature and haven't studied enough science to understand the background cell biology and biochemistry. They haven't noticed the broad applicability of insights into the gut microbiome.
I don't think that bile reflux is anything other than another form of GERD, which is stomach and intestinal contents pushed up the GI tract as a result of gas build up in the small intestines due to SIBO, small intestine bacterial overgrowth. The stomach valves open in response to low stomach acid and the GI pressure forces the contents up to the esophagus. Celiac commonly results in SIBO.
Celiac starts with antibodies to ATI/LTP and then spreads to include antibodies to gluten and other intestine proteins. Avoiding a target antigen does not eliminate the antibodies to that antigen. Avoiding gluten lessens symptoms, but does not cure celiac. Celiac is the most complex of the autoimmune diseases to cure, because it also compromises the lining of the gut and further disrupts gut bacteria and the gut based development of the whole immune system.
It is possible to cure autoimmune diseases, but not through immune modulating therapy, which just shifts the types of antibodies produced. It is not good to shift from allergies to autoimmunity.
Antibodies to wheat ATI also bind to LTPs and gluten. The immune presentation of gluten requires binding to intestinal transglutaminase, and that causes full blown celiac and thyroid problems. Your problems started with damage to your gut flora and reduced Tregs/deficient immune tolerance, then exposure to wheat ATI, which typically results in antibodies to ATI and gluten, led in your case to antibodies to related LTPs. You are probably already getting attack on your thyroid, which can produce either elevated or low thyroid hormones. After the antibodies are produced and broadened to include other antigen targets, it doesn't matter if wheat is discontinued, because the new antigen targets maintain the allergies and autoimmunity. The only solution is to fix the root cause, deficient immune tolerance due to low Tregs caused by damaged gut flora.
Do a Google search for The Potato Hack and the author, Tim Steele. Also read up on phytoalexins, natural antibiotics produced by plants. Natural antibiotics have the same impact as commercial antibiotics. Also read up on live, fermented vegetables.
Read up on SIBO and realize that antibiotic treatments will further damage your immune system. You need non-antibiotic approaches. Also note that increasing your gut acidity is necessary and starving your SIBO while feeding your colon bacteria prebiotic fiber may be a major goal. Your immune system is not overactive, but rather it is deficient in immune tolerance. SIBO kills immune system development in the gut.
Why don't you mention meat/fish/eggs, soy and dairy? It seems that many of your problems may stem from vitamin deficiencies associated with celiac and damaged gut bacteria. The reflux is clearly SIBO. Have you had your serum vitamin D measured? I would be amazed if you weren't highly inflamed from vitamin D deficiency.
- October 6, 2016 at 4:00 PM
I am speechless. First of all, thank you. Your help is so precious to me. I have been studying and asking hundreds of doctors over the years for an answer to this LTP allergy, and only now I have an explanation. I remember having an IgE test pre-pregnancy, about 10 years ago, it showed I was allergic to wheat, tomatoes, corn, rice, onions, garlic, peach, nuts, seeds, over 50 plant related foods. My allergy specialist dismissed it saying "it is not possible to be allergic to all of this". Since I did not have any symptoms he told me to keep eating everything. Maybe this has inflamed and damaged my gut flora during the years. Celiac, SIBO.. Gosh. I just ordered Probiotics-3 on Amazon and the potato starch. I'll start with that and keep my diet. I do not eat any form of processed food or sugar. I do eat eggs, fish and meat, some fruit and those few vegetables I tolerate. Would that be a good start for now? If you think I could benefit from other supplements please let me know. I do not tolerate dairy very well unfortunately, as it sometimes triggers my heartburn. I am still very underweight! I avoid drugs/antibiotics etc as I know they don't treat the root cause of my condition. I was deficient in vitamin D yes. I took 5,000 daily for a few months, I'll check my levels again soon. In my family nobody has food/pollen allergies but both my father and my sister have thyroid disorders. Professor Ayers, I know this is just another thank you comment from an ill person, but to me this means the world! I passed this LTP condition to my little daughter and now I have an even bigger motivation to find a way out. Thank you for passing your knowledge on this to me. Angela
- October 7, 2016 at 5:17 AM
I have read on SIBO and natural antibiotics. I feel you might be right in my case and SIBO could be my underlying cause. In the diet there are a few restrictions. My daily diet consists of chicory coffee (no coffee), baked potato, lamb, poultry, salad, beetroot, cucumbers, fish, brown rice pasta/crackers, blueberries, figs. I use coconut oil coconut butter, jam (no sugar added) and raw honey. Not sure what I need to eliminate out of this for the SIBO diet as from what I read there should be NO carbs at all? Any advice would be truly useful. I am currently taking probiotic-3 (they have been a miracle as they helped me to put weight on, don't know how!!) and saccharomyces boulardii. I also take magnesium and elderberry syrup (homemade). Thank you Professor! Angela
- November 11, 2016 at 10:00 AM
- mc said...
Dear all,
In autoimmune thyroiditis patients, two studies showed no deficit in Treg number, but:
"a defect in Treg function in both Hashimoto and Graves, despite the distinct pathophysiology of these diseases".
(source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704106/)
So, if numbers are OK, how to normalize Treg function?
Please comment, I found Your advice very useful
- January 30, 2017 at 8:39 AM
After 1 week of potato starch, just 1 tsp in water, twice daily, taken with probiotic-3, I developed temperature, watery stools and body aches. Diarrhea is everyday over a week now. I feel it's the potato starch as it is the one thing I've added to my diet. Unfortunately it seems I can't tolerate probiotic-3 as much as before for some reason now which is a disaster. This probiotic helped me with gaining food tolerance as well as some healthy weight, which I have now all lost. I truly do not know what to do. Would miyarisan be a decent alternative since it still contain c butyricum? Angela :(
- January 31, 2017 at 3:45 AM
Dr Ayers, what are your thoughts on the blood group diet? It'd be great to have your knowledgeable point of view on this so discussed theory.
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You state 'In humans, extensive antibiotic treatment produces defective immune systems that are either overly aggressive, i.e. autoimmune, or susceptible to infection and cancer. They can't be both'. I don't understand how then, people in my family have both autoimmune disease and cancer at the same time? I fid this is not uncommon as I have known several people with autoimmune disease and cancer? Is it possible that the idea of an 'over-active' immune system in relation to autoimmune disease is a misnoma? That in fact the body is mistaking our cells for the remarkably similar looking ones in bacteria that have translocated around the body? I for example have connective tissue disease and Klebsiella Pneumoniae in the gut. Strings of protein in Klebsiella bear resemblance to human joint tissue...coincidence? Perhaps. I think autoimmunity is in fact the body doing exactly what it should be doing in response to pathogens. We just haven't so far identified the presence of the pathogens, or recognised their significance.
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When to Take the Tests
The best approach to determine which Subject Tests to take is to plan ahead starting in 9th grade and take any test that provides you an opportunity to get a top notch score. Since Subject Tests are more aligned to specific course content, it's best to take the tests right after you take the course that relates to it. Students who take Biology in 10th grade and are not planning to take Biology again in high school should consider taking the SAT Subject Test in Biology in June of the 10th grade. This will ensure that the content is fresh in the mind and improve the odds of getting a great score.
A second reason you should think about the tests as early as 9th grade is that by the time you know your actual list of colleges you plan to apply to, it's often very late in the admission planning cycle (11th or 12th grade), and you have a million other things to do. If you start early you make your 11th and 12th grades easier and more effective.
A third reason to start thinking about the test early is that Subject Tests are administered at the same time and place as the SAT, and thus cannot be taken on the same day as the SAT. This means that during your 11th and 12th grade, you have limited opportunities to take the test because you have to take the SAT and do other things. However during 9th and 10th
grade, when you're not worried about taking the SAT, you have more dates to choose from and greater control of when you take an SAT Subject Test.
So, start early and plan ahead, and you will be able to count on several Subject Tests that will make your application stand out.

subset: commoncrawl


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The cart is empty
You knew when you planned the ride it would be a long day - a route stacked with grinding climbs and twisting descents, terrible roads with a good amount of who-knows-what-else thrown in. These rides aren't most people's idea of fun, but they sure are memorable, monumental, challenging. Is that why you keep going? You suck down another coffee and pull on your shoe covers to hold the weather at bay, it's going to clear out and warm up in a few hours... Probably. Grab your Avant and do a quick check before rolling into the morning mist. No other machine could better help you endure the hours of rough, exhausting conditions ahead. It's going to be a long day - and you love it.


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We're proud to unveil our new arms, the PhantomX Reactor Robot Arm and its little brother the PhantomX Pincher Robot Arm. These arms are based around the Dynamixel AX-12 Robot Servos and are controlled with the Arbotix RoboController, so you have an amazing amount of control over these arms. The Reactor Arm also has a 'Wrist Rotate' option, to add another level of functionality to your arm.
Stay tuned for more videos about the design of this arm, as well as examples of all of the amazing things it can do.


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Andrew Crane, Professor of Policy/Strategy, the George R. Gardiner Professor of Business Ethics and Director of the Centre of Excellence in Responsible Business at Schulich School of Business at York University
Mr. Crane's research and teaching explore new ways of thinking about the social, ethical and environmental dimensions of business. He is particularly known for his work on the changing role of the corporation in the global economy, where he has been influential in developing a new view of corporate citizenship that addresses the political roles and responsibilities of business. He has also focused on how ideas of ethics, freedom, and responsibility are communicated and made meaningful by corporations, consumers and other stakeholders through talk and text. Mr. Crane and his colleague, Dirk Matten, Professor of Strategic Management/Policy, Hewlett-Packard Chair in Corporate Social Responsibility and Co-director of the Centre of Excellence in Responsible Business, maintain the popular Crane and Matten. Blog http://craneandmatten.blogspot.ca
Twitter @ethicscrane


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Bakersfield Feasts On Second Chances In Win Over Skyforce
More shots taken because of offensive rebounds collected is a simple formula to win a game. When everything else ends up equal, that's all you need as the Bakersfield Jam (11-6) topped the Sioux Falls Skyforce (10-7) 103-88 at the NBA Development League Showcase.
Field goal percentages, free throw makes and misses, turnovers, assists all virtually were even. However, the Jam shot 97 times to 80 for the Skyforce mostly due to 20 offensive rebounds. Eight of the nine player for Bakersfield got at least one offensive board. By contrast, Sioux Falls as a team had six. For two and a half quarters, it seemed as if the 'Force was dying a slow death. In between stretches of trading baskets, the Jam seemingly would get an extra basket off a missed shot eventually leading by 20 points. The margin dwindled down to 8 early in the fourth quarter, but the Jam was able to increase the spread again to 22 before settling at the final margin of 15.
Bakersfield had a trio of players score 18 points including all-time top scorer and former 'Force player Renaldo Major. Jerel McNeal and Shan Foster were the other two at the top of the list. Sioux Falls got 22 from Demetris Nichols while NBA assignee Dexter Pittman posted a double-double of 13 points and 10 rebounds. The D-League Showcase continues through Thursday in Reno, Nevada with both teams making one more appearance. Bakersfield will play the Maine Red Claws while Sioux Falls takes on the Springfield Armor with both games on Wednesday.


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Living Technology: la(te)st installment of Wii Max Granu Boids tomfoolerydesign | emergence | hci | idmi | interface | Max | social | software | Wii
This piece shows the latest and last of my experiments in Wii-based gestural control of image elements (MaxMSP-generated pixels swarms using a modified version of Craig Reynold's venerable boids algorithm).
The soundtrack features complexity theorist Norman Packard speaking about his work and views regarding synthetic biology -- the creation of life from basic elements and information. Created for Professor Joshua Goldberg's class in physical interactive media production at Brooklyn Polytechnic (now part of New York University).
Wii Max Granu Boids gestural interface demo (featuring Howard Rheingold on Cooperation Theory)design | emergence | hci | idmi | interface | Max | social | software | Wii
This performance demonstrates my evolving Wii-Max/MSP gestural interface prototype.
Beginning with Howard Rheingold's brilliant interview on cooperation theory, I used the Wii controller to manipulate audio with a granular synthesis patch, and filled the video track with flocking pixels based on Craig Reynold's famous Boids algorithm in an OpenGL Jitter implementation.
Closer to e-book reality: Amazon Kindledesign | disruptive | e-book | ecology | future | innovation | media | wireless
Just announced last month is the strangely styled and potentially disruptive new e-book reader from Amazon, dubbed "Kindle." I don't know about you but that title makes me think of Bradbury's Fahrenheit 451... Get video, images and blurbs from Amazon or google it for alternate perspectives.
Chief on the features list is wireless connectivity -- with no monthly fee -- using Sprint's high-speed (EVDO) network, more like an advanced mobile phone than a laptop with wi-fi. The gadget sells for 400. USD and early sign seem to suggest success -- it's sold out between now and Christmas....
Exploring gestural interface principles through Wii remote+Max/MSP granular synth mashupbehaviour | computing | games | interaction | invention | Wiimote
I developed this gestural interface prototype that offers an intuitive and performance-friendly interaction model. I'm exploiting the physicality of Nintendo's Wii controller by aiming to drawing out visceral, subtle, and "quasi-analogue" possibilities.
To build the prototype I combined functions from two existing Max patches: aka.wiiremote Nintendo Wii Remote Handler by Masayuki Akamatsu and granularized by Les & Zoax.
designswarm | Alexandra Deschamps-Sonsino | Interaction Designcomplexity | design | experience | interaction | metabolo.org | physical | virtual
"Alexandra Deschamps-Sonsino, freelance interaction designer. I am interested in the way service design ties product design and interaction design together to create meaningful experiences for people both in the virtual and tangible worlds."
ACADIA 2007 : Expanding Bodies : Metabolic Network sensory workshoparchitecture | art | biology | computing | design | metabolo.org | science
Metabolism, in living systems, has two aspects: anabolism (building up), and catabolism (breaking down). This two-day workshop in electronic sensing in art and design has a special focus on textiles and architectural-scale applications.
Socially responsible, psychologically healthy, highly creative design workplaces
I was recently asked (through a Facebook message) if I know any workplaces or firms that offer a complex, critical and creative design philosophy, as well as a great working environment, anywhere in the world. Would I recommend IDEO? Or, are there any more socially responsible firms to look at?
I had to say that the question is a good one but not so easy to answer.
I think social responsibility is one area, psychologically healthy working environment is another, and creative process is another, and few firms manage to accomplish all of those well.
For new issues in social responsibility one book I like is Thackara's "In the Bubble." As well, the people at World Changing are on the right track. I learned (through LinkedIn) that my formeer Institute without Boundaries student, the highly talented Jennifer Leonard, is now an editor there, which is fabulous news.
Architectures of Control v. Designing for Emergencebehaviour | control | design | experience | interaction | systems
In the course of research for my Media Law paper, on Creative Commons and designing for emergence in law, I came across this excellent blog. In many ways this site might be considered the opposite of "designing for emergence":
Architectures of Control
What are Architectures of Control?
[example images - Audi A2: The user cannot open the bonnet; Bench designed to prevent lying down: 'redesigned to face contemporary urban realities'; printer: Some HP printers shut down the cartridges at a pre-determined date regardless of whether they are empty]
Short and sweet: succinct definitions of designcommunication | design | language | learning
I wrote my own shortest definition of design as a personal challenge to express the term in a manner that was brief, robust and circumspect. The result (discussed elsewhere in this blog):
"Design is creation for reproduction."
Another short definition that I greatly admire was sent to me by Richard Thomas, a colleague at the Beal Institute for Strategic Creativity. Ricky said:
"Design is the process of initiating and representing relationships."
Doug Chapman, whom I know as an actor, environmentalist, former director of research at William McDonough + Partners, and graduate of the Institute without Boundaries program I directed until 2003, recently offered this very concise statement:
"Design is the line between idea and result."
In Toothpicks and Logos: Design in Everyday Life (2002, Oxford University Press), John J. Heskett highlights the multivalent senses of the word "design" by offering and analyzing a bewildering sentence:
"Design is to design a design to produce a design."
"Design," says Heskett, "has splintered into ever-greater subdivisions of practice without any overarching concept or organization, and can be appropriated by anyone."
While I don't consider this situation to be alarming, I do believe in this time of great change and great opportunity that practitioners and theorists of contemporary design will benefit by having a sense of what they have in common with those flying the same colours.
Biomedia: GVA @ Beal Institute's Weekly Show+Tell, March 29, 2007Biomimetics | bionics | communications | cybernetics | media | sustainability
With the encouragement of Alexander Manu, Director of the Beal Institute for Strategic Creativity, I am scheduled to present highlights from my ongoing graduate work toward a Master of Science degree in Integrated Digital Media. Beginning at 3:30 pm I'll present for an hour, at the Beal, 100 McCaul Street, 6th floor, Toronto. I'll start with work from last semester (History of Media + Philosophy and Media). Later on, in another session, I will cover the current semester (Media Law e.g. copyright, trademarks, free speech, libel etc and a Media Studies course on the Situationists, Guy Debord, détournement, post-situationist mashup culture etc).
Are Designers the Enemy of Design?change | design | emergence | innovation | participation | web2.0
Patrick Keenan from The Movement sent me this provocative link, which underscores the arguments Bob Logan and I are making in the Designing for Emergence papers:
From Businessweek.com's
Nussbaum on Design column
March 18, 2007
Are Designers The Enemy Of Design?
Bruce Nussbaum
Here's the speech I gave at Parson's on Thursday that deals with the backlash against design. I've edited it just a bit. It's designed to provoke design management students and show how I've redesigned my job at Business Week from the Voice Of Authority to the Curator of the Conversation on Innovation. We all live life in beta now.
"How to Realize a Gallery Exhibition Based on Design-Oriented Content"art | change | communication | design | future | research
I was recently contacted about the Massive Change project by Matt Garmon, a student of OCAD where I'm currently teaching design. Following are his intro letter and interview questions, along with my answers.
"Hi Greg. I am currently in Todd Falkowsky's 3rd year Thesis Prep class at Ontario College of Art & Design. I am working on a case study based on the Massive Change project and was wondering if I could interview you to gain some personal insight into the project.
Specifically, I'm using the Massive Change exhibit as a model for how to effectively organize and realize a gallery exhibition based on design-oriented content. Your expertise and personal experience with this project would definitely help me generate a content-rich study and would be greatly appreciated. Would you be available to answer the following questions?"
1) What was the biggest obstacle/hurdle that the team encountered while working on the project? How did you overcome it?
In writing, curating and designing Massive Change, the biggest challenge was the overall ambition of the project. By this I mean the implications and reach of the critical questions, the sheer number and variety of deliverables, and the magnitude of the stakes.
On the Crisis of Art: MAK's Agenda Art 2010
At the request of of Vienna-based contemporary art museum the MAK, I prepared this text contribution for their their annual report, Agenda Art 2010. The museum described it as "perfect for the agenda":
For solutions to the current crisis of art we must first realize the underlying causes. It is a matter of perspective and posture.
Art presents itself as a critical commentary on social and productive relations, from a perspective of exteriority. And so, when it is increasingly impossible to say there is an inside and an outside, then what?
As an activity within a complex economic and semiotic ecosystem, art proudly occupies an idiosyncratic niche. What then, when all perspectives and positions increasingly resemble niches?
Art's stance is predicated on independence and an aversion to reciprocal complicity. And when we realize that emergence within a field of reciprocal complicity is the source of all consciousness, all sociality, all economics, of life itself -- then what?
It may be necessary for art to die and be reborn for it to discard its inherited identity. It may be that a new art, in its interiority, its pervasiveness, its complicity, is unrecognizable. It may be.
Dear Professor Spooky, My Avatar Dog Ate My Homeworkaudio | invention | learning | media | organization | remix | research
As it turns out my Media Law class this semester may be held in Second Life. One reason this idea is looking cool is that DJ Spooky is already dropping science in that polygonish sandbox. Check out his course outline below -- interesting stuff for remixers, duality junkies, and Spooky fans -- and an awsome playlist in itself...
-----Original Message-----
From: firstname.lastname@example.com [mailto:email@example.com] On Behalf Of Paul D. Miller
Sent: Monday, January 22, 2007 1:18 PM
To: firstname.lastname@example.com
Subject: [iDC] sharing Curriculum
Hello everyone: I'm now at Sundance Film Festival for a series of discussions aout how new media is forcing the film industry to evolve different production models. To highlight the situation, the discussion will focus on Lynn Hershmann's film on Steve Kurtz: "Strange Culture"
But in light of the thread about teaching new media, here's the syllabus for my class on remix culture and digital media, with a focus on how people will respond to the material via PDF and remixable DVD's:
Paul aka DJ Spooky
(ps, this is sent from my cell phone, so, ahem, it aint really spell checked etc etc)
MEDIA SOUNDS: Towards a New Esthetic of Music and Art
PAUL D. MILLER aka DJ SPOOKY
Class notes: In Brief - "Media Sounds: Towards a Philosophy of Aesthetics in Music and Art" is a course I'm teaching at the European Graduate School as a mini residency during the summer. The school is kind of a 21st century update of the Black Mountain College: it brings together a wide variety of people from radically disparate philosophical and aesthetic backgrounds to teach and enjoy ideas outside of the academic norms.
My class focuses on sound, sound art, and their relationship to compositional strategy across different forms of contemporary art and digital media. This is the syllabus.
Invitation to contribute to Agenda Art 2010art | creativity | future | globalization | history | networks
I received an invitation from Peter Noever, director of Vienna-based contemporary art museum the MAK, to contribute a piece of writing to their annual report. Peter wrote:
The MAK has always seen itself as a place of social awareness beyond its assigned function as a site of art and a laboratory of art production. Under the heading of "AGENDA ART 2010," we are now trying to draw up scenarios on the future of art: Which production conditions, which values in society, which extent of interaction with politics and the economy would be desirable for art? And how can these scenarios be made real? An avant-garde paper of this style can only be developed with the help of visionary minds from the fields of art, architecture, design, and the humanities.


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Artist Rhode Montijo's amazing Haunt, just packed with all things Halloween.
And click here for a very short and very cool video of the scarecrow.
Kinda giddy over these photos.
Thanks, Rhode!
Wednesday, November 30, 2011
Rhode Montijo's Halloween 2011
Artist Rhode Montijo's amazing Haunt, just packed with all things Halloween.
Posted by Rot at 7:13 PM
Labels: jack o'lanterns, old school, reaper, rhode montijo, scarecrow, Scarecrows, yard haunt, yard haunts
6 comments:
- crudedoodle.com said...
pretty great haunt! This is the kind you'd hate to leave as a kid, afraid you'd miss something after getting your candy.
- November 30, 2011 at 7:55 PM
- Rot said...
Pretty awesome to see the style of his paintings come to life in a physical Haunt.
Just wonderful.
- November 30, 2011 at 8:07 PM
- Pam Morris said...
some truly great characters here--esp. that first one--the reaper with the guy's head is really great!
- November 30, 2011 at 9:21 PM
- wicKED said...
That is just plain great. What I would not give to see something like that in real life.
- December 1, 2011 at 12:40 AM
- Jay's Shadow said...
Lots of old school Halloween goodness....
- December 1, 2011 at 7:21 AM
- bean said...
Words cannot express how much I love this.
- December 1, 2011 at 8:24 AM
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