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USSF D-2 Pro League Standout to Join Defending MLS Cup Champs for Stretch Drive of 2010 Campaign
SANDY, Utah (Thursday, September 9, 2010) – Real Salt Lake today announced the acquisition of FW Paulo Araujo Jr. via a loan deal with Miami FC of the USSF D-2 Pro League. The loan arrangement will keep the Brazilian striker, a member of the reigning MLS Cup champion through the remainder of its 2010 season, including the MLS Cup Playoffs. Paulo Jr. will be available for selection for Real Salt Lake when the Utah side takes on Seattle Sounders FC this evening at Qwest Field (9:00 p.m. MT, live on ESPN2/ESPN Deportes).
Paulo Jr. will occupy the last of Real Salt Lake's five available International player roster slots, joining the Argentinean trio of FW Fabian Espindola, MF Nelson Gonzalez, and MF Javier Morales; and Costa Rican FW Álvaro Saborío on the list.
"We are excited to add a forward like Paulo to give us as many options up top as possible as we push through our congested schedule of CONCACAF and League games at the end of our season," said RSL General Manager Garth Lagerwey.
Paulo Jr. joins Real Salt Lake after notching four assists and scoring a team-high eight goals in 22 appearances (18 starts) in USSF D-2 Pro League play, which ranked him tied for fifth on the 12-team league's goal-scoring chart at the time of his departure. In addition, Paulo Jr. ranks as the co-leading scorer of the 2010 edition of the Lamar Hunt U.S. Open Cup, his five goals in three games tying him with Nate Jaqua of tournament finalist Seattle Sounders FC for the competition's scoring lead.
The 21-year-old attacker – who will don "Paulo" on his RSL jersey in the tradition of Brazilian players – began his professional career with Campeonato Brasileiro Série C club Ituano in 2008 before signing with Miami FC in 2009. During his first season with the South Florida side last year, Paulo Jr. tallied three goals and three assists in 18 league matches in USL First Division play.
Full Name: Paulo Morais de Araujo Junior
Pronunciation: ah-RAH-ho
Position: Forward
Height: 5' 7'' Weight: 158 lbs.
Born: January 23, 1989 in Teresina, Brazil
Hometown: Teresina, Brazil
Citizenship: Brazil
College: N/A
MLS Experience: 1st Season
Last Club: Miami FC (2010)
Professional Career
2010: Miami FC (USSF D-2 Pro League): Started in 18 of his 22 matches with Miami FC in League play, registering a team-high 8 goals and adding 4 assists across 1,675 minutes of action … At the time of his departure, ranked in USSF D-2's top five with 20 points (3rd), 8 goals (T-4th), and 50 shots (5th) … Also scored five times in three Lamar Hunt U.S. Open Cup contests, his five goals ranking at the top of the competition's scoring chart heading into the Final (tied with Seattle's Nate Jaqua) … Four of those goals came during a 10-minute span in added extra time in Miami FC's First Round 5-1 win over the Central Florida Kraze (PDL) on June 15 … Also tallied the Blues' opener (2') a week later in the squad's 2-1 (AET) victory over fellow D-2 side Tampa Bay … Started and went the full 90 minutes on June 29 at Houston Dynamo in a 0-1 Third Round defeat … Re-signed with Miami on March 15 for its 2010 season.
2009: Miami FC (USL First Division): Notched three goals
and three assists across 18 appearances in his first season with Miami … Made
his Blues debut on May 20 v. Charleston Battery, and scored his first USL goal
a month later on June 20 vs. Cleveland City Stars
2008: Ituano FC (Campeonato Brasileiro Série C): Began his professional career in 2008 with Ituano FC of the Campeonato Brasileiro Série C before signing with Miami FC in 2009.
Born Paulo Morais de Araujo Junior in Teresina, Brazil
TRANSACTION: Real Salt Lake acquires forward Paulo Araujo Jr. on loan from USSF D-2 Pro League's Miami FC for remainder of 2010 MLS season.
www.RealSaltLake.com / www.RioTintoStadium.com / www.RSLtotheCore.com / www.ESPN700Sports.com


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The Apprentice Boys of Derry Association is a Christian, historical and cultural organisation whose spirit is sustained and promoted by organising parades, exhibitions, lectures, music, art and drama.
The Apprentice Boys' main celebrations are focused in the city of Londonderry and primarily within the historic city walls. There are two main celebrations held in the city, in August and December.
The Siege Museum is an extensive display of the history of the Siege of Londonderry and of the Associated Clubs of the Apprentice Boys of Derry, including artefacts, video and interactive media.
The Apprentice Boys of Derry Association is a Christian, historical and cultural organisation, committed to maintaining the spirit of courage and liberty displayed by the Defenders of Londonderry in 1688-1689
There are eight Parent Clubs based in Londonderry, symbolising the regiments formed during the siege to defend the city; Branch Clubs are located across the UK, the Republic of Ireland & Canada.
"A people who take no pride in the noble achievements of remote ancestors, will never achieve anything worthy,
to be remembered with pride, by remote descendants..."


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This is not an offer for credit and should be used for estimation purposes only based on the information you provided. You should not base your decision on this estimate alone. Title, registration, tax and other fees, and personal circumstances such as employment status and personal credit history, were not considered in the calculations.
8-valve single overhead cam (SOHC)
Inline 4
Big Tiller Compatible
Computer controlled Multi-Port Electronic Fuel Injection (EFI)
Performance-tuned scroll intake manifold
Power Tilt
Power Trim
*Price, if shown, is Manufacturer's Suggested Retail Price (MSRP) and does not include government fees, taxes, dealer vehicle freight/preparation, dealer document preparation charges or any finance charges (if applicable). MSRP and/or final actual sales price will vary depending on options or accessories selected.


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RV Forum flags - click HERE
Wendy, so substituting a crack habit is not a good sub for smoking? I used peppermint lifesavers. I wasn't even a menthol smoker.
"Healthier" was the important word And for me it was peppermint sticks and I was a menthol smoker.
Ray - how ya doing?
Gotta tell ya what's cool.... Forgot about posting for the past couple weeks, same story, getting boring now, still on that wagon! Feel's much too nice to ruin this easy breathing frankly, 35yrs of smok'in is done! Six weeks down coming this weekend, it's getting easier by the day now, good sign I think.
I quit a few months ago after reading "The Easy Way to Quit Smoking". I highly recommend it! I wish you the best!
How's it going Jim and Ray? Still on the wagon I hope. Decided to climb on with both of you!!!
I'm still smoking and from I gather you are doing much better than I.
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GenealogyCanada's Blog Search - Yes, using our very own search box (at the top right), just type in "Irish" or "Ireland", and see what resources or news items have been posted here. (This also works for other topics of interest).
The Irish Canadian Society http://www.irishcanadiansociety.net/ - This website etablished a connection between Canada and Ireland, and gives an account of how to search for Irish immigants.
Irish Resources at Library and Archives Canada (LAC) www.collectionscanada.gc.ca/genealogy/022-905.005-e.html - Canada's most recent census returns list the Irish as the fourth-largest ethnic group in Canada, with almost 4.5 million Canadians claiming either some or full Irish lineage.
Irish Ships Passenger Lists www.rootsweb.ancestry.com/~ote/iriship.htm
Canadian Immigration Records: Irish Immigrants www.irish-genealogy-toolkit.com/Canadian-immigration-records.html - Canadian immigration records on Irish immigrants.
Grandma's Family Tree http://judycorbettbarker.com/index.html - Judy Barker is tracing the surnames of CORBETT, HAWCO, COSTIGAN, FUREY, KENNEDY, LACOUR, MURPHY, QUINLAN, CRAIG, HEALEY, and SULLIVAN from Ireland. They emigrated to Chapel`s Cove, Harbour Main, and Holyrood in Newfoundland.
Emigration From Cork Island to Upper Canada: The First Peter Robinson Settlers http://webhome.idirect.com/~obrienr/cork1823.html - The website explains the reasons behind emigration to Canada, and lists other websites.
Discover Your True Irish Roots in our New Historical Records www.ancestry.ca/irish?o_iid=50529&o_lid=50529&o_sch=Web+Property - Ancestry.ca has Irish Records that you can check online. Their 14-day FREE access offer is available.
I have just published two booklets - The War of 1812: Canada and the United States, and Migration: Canada and the United States.
They are available for purchase through Global Genealogy at http://www.globalgenealogy.com/, the National Institute of Genealogical Studies at http://www.genealogicalstudies.com/, and now, in the U.S., from the Family Roots Publishing Company at http://www.familyrootspublishing.com/.
For more on the booklets, go to http://genealogycanada.blogspot.com/2012/01/booklet-1-war-of-1812-canada-and-united.html and http://genealogycanada.blogspot.com/2012/01/booklet-2-migration-canada-and-united.html


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Les Claypool typically spends evenings onstage rocking out with his band Primus, but he daylights in culinary circles with his Sebastopol-based winery Claypool Cellars. The legendary Bay Area bassist will be pouring bottles of his Russian River Valley wines at a special dinner in the Modernism West gallery at San Francisco's Foreign Cinema restaurant on August 23.
Foreign Cinema chefs Gayle Pirie and John Clark have crafted a five-course feast that includes dishes such as Oaxacan-style squid, duck mousse bruschetta and nectarines, tea-smoked five spice duck breast, and Mexican chocolate cake. Food will be paired with Claypool Cellars specials such as Purple Pachyderm and Pink Platypus, and the 1964 film Dr. Strangelove — Claypool's favorite — will screen during the meal.
Claypool has previously hosted dinners in the North Bay and is known for his whimsical approach to winemaking that even includes how his wine is served. Case in point: Claypool Cellars opened a wine tasting caboose in Sebastopol's Gravenstein Station in 2011.
The Foreign Cinema dinner costs $60; call (415) 648-7600 x 0 to make reservations.


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In a promotional event timed to coincide with the global release of Margaret Atwood's new novel MaddAdam, her publisher, Doubleday, is teaming with Wattpad, the online writing community, to release an exclusive essay about the development of the book as well as excerpts from Oryx and Crake and The Year of The Flood, the other novels in the dystopian trilogy of which it is a part. The acclaimed Canadian novelist is a longtime fan of Wattpad and has published a variety of material on the site.
Atwood will publish an essay on Wattpad about MaddAdam that will give "behind the scenes glimpses into her inspiration for the series," and also "mixes her famous wit with an earnest exploation of the increasingly blurry line between speculative fiction and fact," said Nazia Khan, Wattpad communications manager.
Judy Jacoby, advertising director at Doubleday, said Doubleday plans to bring more authors into the Wattpad community. "Wattpad is such a welcoming and highly engaged community of readers. With its millions of users from all over the globe, we truly believe it's the perfect place for us to get our writers in front of an even larger audience."


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rumhud wrote:Contrabass ophicleide
(Kidding. Sort of.)
We were going to make if the quinticlave had sold well, but that has never taken off - so adding more to the ophicleide range was abandoned. Shame as it would have been fun to have had a contrabass ophicleide - but Wessex has to be run as a profitable business, and not just to produce fun horns


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Kielder Observatory
Black Fell, Near Kielder Village, Northumberland, NE48
Kielder Observatory is one of the best stargazing experiences to be had. It's location within the Northumberland International Dark Sky Park and it's friendly and experienced Astronomers make it a must-visit attraction. Even the journey through Kielder Forest and up the forest track is an amazing experience in itself!
With various themed public events running 7 days a week there is plenty of opportunity to visit however bookings must be made well in advance due to the observatory's popularity, at least several weeks for mid-week events sometimes several months for weekends. Note that event start times vary depending on the time of year.
For the best experience and to see the dark skies ensure you plan your visit around new moon. During summer book the late evening events to avoid the Sun's twilight (and midges!).
Make the most of your trip to this remote location perhaps by staying over at Kielder Campsite, enjoy walks around Europe's largest man-made reservoir and check out the village Pub and Castle cafe both of which serve great food.
- Event includes an astronomy related presentation or talk.
- Event will involve stargazing and observing the skies through telescopes weather permitting
Corona virus
Please be aware that due to the Coronavirus it is likely that this event has been cancelled or postponed. If you are considering attending this event please double check with the event organiser directly to confirm. If this event is indeed affected the organisers will no doubt need your support in the future -- please do consider attending an event of theirs when possible! Thank you!
This event is being organised by Kielder Observatory who should be contacted if you have any queries. We highly recommend you confirm this event is indeed going ahead before travelling. If you do attend it would be fantastic if you could let the organiser know you found them via Go Stargazing!
Please contact Kielder Observatory directly for more details regarding this event or, if appropriate, contact the event venue.
Go to the organiser's web page for this event
Location light pollution
This location is estimated to have light pollution levels similar to a dark site setting based on satellite data from CPRE.
Location darkness on Sunday 22nd October 2017
The below graphic shows if and when it will be dark at Kielder Observatory on the evening of this event. Yellow areas show when the skies are not dark due to daylight (bold yellow) and moonlight (faded yellow). Click on the image for an explanation on how darkness is determined.


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In Part 1 of this series, I set the stage for a discussion of behavioral finance and game theory as they pertain to how market participants behave. In Part 2, I expand upon some of ways that individuals and institutions behave in ways that can be explored from this perspective.
Giving People What They Want
One of the most striking features of the capital markets of the recent year or two has been the 'Las Vegas' feeling to much of the action in the markets. There has been tremendous excitement around IPOs of companies including Zynga (ZNGA), Groupon (GRPN), and most notably Facebook (FB). The hoopla around the Facebook IPO, in particular, is without precedent. Why do the financial media and corporate management work together to create this frenzy? The answer is simple: people buy it. If investors ignored the carnival atmosphere around these firms, we wouldn't see this kind of media. If people say that they want to invest in solid well-run profitable firms, but clearly signal that what they are actually buying is shares in IPOs of companies with enormous dreams but untested business models, we know what Wall Street will provide. If investors seem to be seeking investments that behave like lottery tickets, it is perfectly rational for venture capitalists to fund such companies and to rapidly take them public. I view the marketing of Facebook's IPO as perfectly executed to exploit behavioral biases. I am not a conspiracy theorist, but even the trading delay on the day of the IPO helped to bring the frenzy to own shares to a fever pitch. The Facebook IPO and others like it suggest that Wall Street is very effectively playing a game that many investors do not really understand. Continue reading


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Ixabepilone: an Epothilone for the treatment of Metastatic Breast Cancer
Breast cancer is the most common cancer affecting women in the United States. It was estimated that 178,480 women would be diagnosed with breast cancer in 2007 with approximately 2,030 cases diagnosed in men. Breast cancer ranks second, behind lung cancer, for cancer mortality in the United States. Despite advances in early diagnosis and treatment, approximately 40,910 deaths will be attributed to breast cancer in 2008. Therefore, continued investigation into better treatments for breast cancer is imperative. This program will describe a new class of anti-neoplastic agents known as epothilones and review the pivotal data leading to the approval of ixabepilone (Ixempra®) for the treatment of metastatic breast cancer.
Breast cancer mortality has declined in the United States since 1990. This decline in patient deaths from metastatic breast cancer is thought to be related to improvements in knowledge about early detection, participation in screening through mammography, and increases in the number and efficacy of hormonal and anti-neoplastic agents available for the treatment of metastatic breast cancer. Taxanes are thought to account for much of the improvement in survival.
Overview of Metastatic Breast Cancer
When a woman is originally diagnosed with breast cancer, many aspects of her original tumor are examined to determine her prognosis, which means the likelihood that her breast cancer will recur following definitive surgical therapy. Pathologic prognostic indicators include the size of the original tumor, the presence of lymph node involvement, the extent of lymph node involvement if present, hormone receptor status (estrogen and progesterone receptor positivity or negativity), Her-2-neu status, nuclear grade, histologic subtype, mitotic rate, and the presence of lymphatic or vascular invasion. These indicators are also used to determine the need for additional or adjuvant therapy prior to or following definitive surgery which might include chemotherapy, hormonal or biologic therapy. Newer therapeutic indexes such as Oncotype Dx and Mammoprint can be used as well to assess a woman's recurrence risk. In the adjuvant setting, when chemotherapy is deemed useful, options often include the use of an anthracycline and a taxane.
When a woman is first diagnosed with metastatic breast cancer, the goal of curing her of breast cancer is not currently realistic; however, due to the multitude of options available for the treatment of metastatic disease, it can currently be thought of a chronic disease which may require multiple courses of varying therapies for its treatment. The treatment goals therefore are threefold. First, the goal of therapy is to palliate symptoms, ensuring an adequate and satisfying quality of life. Second is to prolong survival. Third is to prolong the time until disease progression. All three of these treatment goals are included as endpoints in clinical trials evaluating new therapies for the treatment of metastatic breast cancer.
There are several options for treatment when a woman presents with metastatic disease. Again, symptom palliation and therefore supportive care remains a primary focus. Additional agents which may be considered include endocrine or hormonal therapies, chemotherapy agents, and biologically targeted agents. Endocrine options include selective estrogen response modifiers such as tamoxifen and fulvestrant (Faslodex®), aromatase inhibitors such as anastrozole (Arimidex®), exemestane (Aromasin®), letrozole (Femara®), as well as mechanisms for ovarian suppression. Chemotherapy options include taxanes, such as paclitaxel (Taxol®), docetaxel (Taxotere®), and albumin-bound paclitaxel (Abraxane®). Other chemotherapeutic options include anthracyclines; capecitabine, gemcitabine, and navelbine. Biologic agents targeting the her-2 receptor include trastuzumab (Herceptin®) and lapatinib (Tykerb®). Other biologically targeted agents may be used in metastatic breast cancer. Like chemotherapy agents, these agents can be used alone or in combination with other therapies.
When determining the most appropriate therapy for a patient, many factors must be considered. Is the breast cancer hormone receptor positive, making endocrine therapy an option? Is the patient pre-menopausal or post-menopausal? Does the patient have multiple sites of visceral disease? Is the patient symptomatic from her breast cancer? What has the disease free interval been? What is the patient's functional status? These questions must be considered when a patient first presents with metastatic disease and any time a change in therapy is being considered.
Principles of Therapy in Metastatic Breast Cancer
When a cancer cell undergoes cell division, like any other cell in the body, the chromosomes which contain all of the genetic material, or DNA, in the cell must first be replicated. After this complex process is completed, two identical daughter cells are formed. The original strand of DNA is separated by a special enzyme known as topoisomerase. This results in two single strands of DNA which are then replicated creating two identical strands of DNA which form chromosomes. During DNA replication nutrients are converted into nucleic acids, the building blocks of DNA, and are then incorporated into the new identical strand of DNA. At any point of this duplication process, other agents can form bonds with either strand of DNA to prevent its replication. Repair mechanisms are present within the cell to attempt to eliminate this disruption. Once two identical chromosomes have been created, they align themselves in the center of the cell and are then pulled into one of the two identical daughter cells by microtubules. Chemotherapeutic agents work by interfering with various parts of the cell cycle.
Anti-metabolites such as methotrexate or gemcitabine inhibit cell division by substituting themselves for the metabolites that are normally converted into nucleic acids. Without the necessary nucleic acids that would be incorporated into the new strand of DNA, cell division cannot take place resulting in cell death or apoptosis. Topoisomerase inhibitors such as Irinotecan block the enzyme needed to separate the original strands of DNA, inhibiting DNA replication and therefore cell division. Alkylating agents such as doxorubicin or epirubicin cause damage directly to the DNA strands. These drugs bind tightly to the DNA and are resistant to normal cell repair mechanisms. Microtubules are affected by many different chemotherapy drugs. Vinca alkaloids such as vinorelbine act to destabilize microtubules and inhibit the separation of DNA into the two daughter cells, resulting in apoptosis. Taxanes such as paclitaxel or docetaxel work to stabilize the microtubules also preventing the separation of the replicated chromosomes into the two daughter cells, leading to apoptosis. Chemotherapeutic agents that work on different steps in the cell division pathway are often combined to enhance the ability to cause cell death. However, combining chemotherapy agents often leads to greater toxicities, which is of concern in patients with metastatic disease where quality of life is a primary goal.
Despite the multitude of mechanisms that anti-neoplastic agents have to cause cancer cell death, some cancer cells develop mechanisms to resist the effects of those agents. These cancer cells are described as demonstrating multi-drug resistance, which is often accomplished by the cell through an efflux pump known as p-glycoprotein.
Current Treatments for Metastatic Breast Cancer
Anthracyclines are commonly used to treat breast cancer; these include doxorubicin, liposomal doxorubicin, and epirubicin. Anthracyclines interrupt cell division by binding to DNA and causing damage directly to the DNA strands. These drugs can be used alone or in combination chemotherapy regimens with a variety of other antineoplastic agents.
Capecitabine is an anti-metabolite; it was approved in 1998 as single agent for the treatment of metastatic breast cancer in patients who were refractory to an anthracyline and a taxane. The response rate was 20% in these patients. It was approved for use in combination with docetaxel in 2001 for patients with metastatic breast cancer who were resistant to an anthracycline, with a response rate of 42%.
Navelbine, a vinca alkaloid, is a microtubule destabilizing agent approved for use in patients with metastatic breast cancer as a single agent. Response rates vary from 35-59% in first line therapy to 16% in patients previously treated with an anthracycline and a taxane.
Gemcitabine is an anti-metabolite approved for treatment of patients with metastatic breast cancer in combination with paclitaxel who have progressed following an anthracyline.
Trastuzumab is biologic agent, directed against her-2, approved for use as monotherapy and in combination with paclitaxel in patients with metastatic breast cancer who overexpress the her-2 receptor protein. Lapatinib is a biologically targeted agent that is approved for use in combination with capecitabine in her-2 positive patients who have progressed on trastuzumab, an tetracycline, and a taxane.
Overview of Epothilones
Epothilones, like several other groups of anti-neoplastic agents work on the microtubules. Microtubules are the "skeletons" of cells and must be broken down in order for a cell to divide or reproduce. Like taxanes, emotions work by stabilizing microtubules, which prevents the cell from dividing or reproducing, ultimately leading to cell death or apoptosis. Emotions are naturally occurring macro ides. The currently approved ixabepilone is derived from the myxobacterium soragium cellulosum, which is naturally found in African soil.
In vitro studies demonstrated the efficacy of ixabepilone in cancer cell lines previously demonstrated to be taxane-resistant. There are more than 300 epothilones currently under investigation for use in cancer. Two agents, ixabepilone and deoxyepothilone (KOS-862) have completed Phase II clinical trials in breast cancer. Ixabepilone (Ixempra ®) was approved for use in metastatic breast cancer patients in October 2007. It is indicated as a single agent in patients with metastatic breast cancer who have progressed on an anthracycline, taxane, and capecitabine and it is indicated for use in combination with capecitabine in patients with metastatic breast cancer who have progressed on an anthracycline and a taxane.
Epothilones work by binding directly to the β-tubulin subunit on the microtubules and demonstrate the ability to overcome multi-drug-resistance mechanisms, including the p-glycoprotein efflux pump which is thought to confer taxane resistance.
Ixabepilone was studied as monotherapy in four completed Phase II clinical trials evaluating various dosing schedules and infusion times. The Phase II trial that led to its approval as monotherapy enrolled 126 women with locally advanced or metastatic breast cancer that was resistant to an anthracycline, taxane, and capecitabine. The overall response rate was 11.5%, while stable disease was seen in 50% of patients. In first line therapy, response rates have been reported as high as 41.5-57%. A Phase III trial was completed that combined ixabepilone with capecitabine. It enrolled 752 women with metastatic breast cancer that was resistant to anthracycline and a taxane. The overall response rate with the combination was 35% versus 14% with capecitabine alone. Progression free survival was also extended from 4.2 months to 5.8 months (Vahdat et al, 2007).
Deoxyepothilone also completed a Phase II trial in patients with metastatic breast cancer resistant to an anthracycline and a taxane. Twenty percent of patients in this trial responded to therapy (Overmoyer, et al, 2005).
Toxicities associate with Epthothilones
The main side effects seen with ixabepilone included peripheral neuropathy, myelosuppression, hepatic impairment, and hypersensitivity reactions.
Peripheral neuropathy was common, occurring in 63% of patients treated with ixabepilone alone and 67% of patients treated with ixabepilone plus capecitabine; grades 3 and 4 peripheral neuropathy occurred in 14% of patients treated with monotherapy and 23% of patients treated with the combination. After discontinuation of the therapy with ixabepilone, peripheral neuropathy symptoms returned to baseline within 12 weeks in 79% of patients treated with monotherapy and 76% of patients treated with the combination. The mean time to resolution was 4.6 weeks in the monotherapy study and 6.0 weeks in the combination therapy study.
Myelosuppression primarily manifested as neutropenia, which occurred in 23% of patients treated with monotherapy and 36% of patients treated with the combination. Febrile neutropenia occurred in 3% of patients treated with monotherapy and 5% of patients treated with combination therapy.
Ixabepilone in combination with capecitabine is contraindicated in patients with baseline hepatic impairment since the risk of all toxicities and febrile neutropenia was found to be greater in that group. Risk of toxicity was also greater in patients treated with monotherapy, although single agent ixabepilone is not contraindicated in that group of patients. Ixabepilone in combination with capecitabine is contraindicated in patients with AST or ALT > 2.5 times the upper limit of normal or a bilirubin > 1 times the upper limit of normal. Dosage modifications should be made in monotherapy administration for any patients with mild or moderate hepatic impairment.
Lastly, because ixabepilone is formulated with Cremophor, hypersensitivity reactions can occur. Only 1% of patients treated with ixabepilone experienced hypersensitivity reactions. All patients should be pre-medicated with both a H1 (diphenhydramine) and a H2 (Zantac, tagamet) antagonist. Three of the nine patients who experienced HSR were able to be retreated with the addition of a corticosteroid to premedication.
Other toxicities include fatigue/asthenia (weakness), arthralgias/myalgias, alopecia, nausea/vomiting, stomatitis/mucositis, diarrhea, and musculoskeletal pain.
Ixabepilone Administration
Ixabepilone is approved for administration at 40 mg/m 2 IV over 3 hours every 21 days. Patients should be pre-medicated with a H1 and a H2 blocker at least 30 minutes prior to administration. Ixabepilone should be reconstituted with the supplied diluent. Any further dilution must be with Lactated Ringers Solution. The infusion must be completed within 6 hours of final dilution through an appropriate in-line filter with a microporous membrane of 0.2-1.2 microns. DEHP-free infusion containers and administration sets must be used for the infusion.
Peripheral Neuropathy
Since peripheral neuropathy is common complication of epothilone therapy, all patients should have a baseline assessment of their neurologic function and should undergo routine assessment prior to each dose. If grade 2 peripheral neuropathy persists longer than 7 days, a 20% dose reduction should be instituted. Patients experiencing grade 3 peripheral neuropathy lasting less than 7 days should also receive a dose reduction of 20%. If grade 3 peripheral neuropathy persists longer than 7 days, ixabepilone should be discontinued.
Various clinical tools can be utilized to document neurotoxicity including the NCI common toxicity criteria, the Mini-Mental status examination, Jebson Test of Hand Function, and the Grooved Peg Board Test, to name a few. As part of the baseline assessment, evaluation of all other medical conditions should be documented and considered including prior chemotherapy exposure, history of diabetes or neuropathies and age.
For patients who do experience peripheral neuropathy, supportive measures should be instituted. Pain can managed with narcotic and non-narcotic pain medications and neuroprotectant agents, such as gabapentin, pamelor, elavil and pregabalin, can be instituted if appropriate. No agents have been identified to correct or prevent peripheral neuropathy, although many clinical trials are currently underway addressing this issue. Safety can be an issue for patients with neuropathy and referral to a physical or occupational therapist may be appropriate. Patients should also be reminded of safety issues, including decreased temperature sensitivity, using caution on steps and walking at night, and to check their feet daily for the development of any sores.
Hypersensitivity Reactions
Hypersensitivty reactions occur because of a reaction of the immune system to the agent infused or the diluent. These reactions are characterized by nausea, vomiting, flushing, bronchospasm, shortness of breath, rashes, urticaria, angioedema, back pain, alterations in blood pressure and heart rate. Hypersensitivity reactions to epothilones should be managed in the same manner that other hypersensitivity reactions are treated. Due to the risk of these reactions, patients should be pre-medicated with both a H1- and a H2-blocker one hour prior to the infusion. If a patient begins to experience these symptoms, the infusion should be stopped immediately and basic life supporting steps should be initiated to maintain airway, breathing, and circulation. Supportive care should include oxygen, corticosteroids, epinephrine, H2-blockers and IV fluid, among others.
Patients with a history of a hypersensitivity reaction to cremophor (as is used in paclitaxel) or its derivatives should not be treated with ixabepilone. In clinical studies with ixabepilone, only 1% of patients experienced severe hypersensitivity reactions. One third of those patients were able to be retreated; however, patients who experience a hypersensitivity reaction should be pre-medicated with corticosteroids in addition to the H1- and H2-blocker in all subsequent cycles. Extension of the infusion time should also be considered.
Myelosuppression resulting from ixabepilone is primarily manifested as neutropenia. Grade 4 neutropenia (ANC < 500 cells/mm 3) occurred in 36% of patients receiving ixabepilone in combination with capecitabine and 23% of patients treated with monotherapy. Febrile neutropenia was rare, affecting 5% of patients treated with the combination and 6% of patients treated with monotherapy. In patients with normal to mild impairment of liver function treated with the combination of ixabepilone and capecitabine, the rate of neutropenia-related death was 1.9% compared with 29% of patients with pre-existing hepatic impairment. Patients with hepatic impairment should not be treated with the combination of ixabepilone and capecitabine. In patients treated with monotherapy, only 0.4% experienced neutropenic fever.
Patients should have an absolute neutrophil count greater than 1500 cells/mm 3 prior to receiving ixabepilone and a platelet count greater than 100,000 cells/mm 3. Dose reductions by 20% should be instituted for all patients who experience grade 4 neutropenia lasting longer than 7 days, febrile neutropenia, platelets less than 25,000 cells/mm 3 or platelets less than 50,000 cells/mm 3 associated with bleeding.
Other side effects that require appropriate nursing interventions include nausea, vomiting, diarrhea, mucositis and stomatitis. Patient education remains the cornerstone to providing safe and effective care for patients with metastatic breast cancer.
Nursing Considerations for the patient receiving an Epothilone
There are a large number of women diagnosed with breast cancer in the United States each year. While many of the cases of diagnosed breast cancer are found in an early stage, a high percentage of women will go on to develop metastatic disease. All nurses who care for women with metastatic breast cancer should be aware of the current treatments available for use in this patient population. Ixabepilone, and perhaps other epothilones in the near future, can be a treatment option for these women. Nurses who care for patients receiving epothilones should be aware of the various infusion times and schedules for each drug. They should also be aware of the diluent used to reconstitute each epothilone and the pre-medications required for each drug. Additionally, they must be able to provide adequate education to the patient receiving an epothilone about possible side effects, including hypersensitivity reaction, and times to call their provider's office. Nurses should also familiarize themselves with the tools available to measure neurologic function and specifically peripheral neuropathy.
Many clinical trials are currently underway to examine the safety and efficacy of other epothilones as well as the ability to combine epothilones with other well established agents used for the treatment of metastatic breast cancer.
American Cancer Society, Cancer Statistics, 2007
Blum, J.L. Phase II study of eribulin mesylate (E7389) in patients with heavily pretreated advanced breast cancer. Abstract - No. 223, 2007 Breast Cancer Symposium.
Denduluri, N., J. J. Lee, et al. (2007). "Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer." Invest New Drugs 25(1): 63-7.
Denduluri, N., J. A. Low, et al. (2007). "Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes." J Clin Oncol 25(23): 3421-7.
Gobel, B.H. Hypersensitivity reactions to biological drugs. Semin Oncol Nurs. 2007 Aug; 23 ( 3 ): 191-200.
Gobel, B.H. Chemotherapy-induced hypersensitivity reactions. Oncol Nurs Forum. 2005 Sep 1; 32( 5): 1027-35.
Ixempra Package Insert, 2007.
O'Shaughnessy, J., D. Miles, et al. (2002). "Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial results." J Clin Oncol 20(12): 2812-23.
Overmoyer, B. Phase II trial of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer. Abstract - No. 778, 2005 ASCO Annual Meeting.
Perez, E. A., G. Lerzo, et al. (2007). "Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine." J Clin Oncol 25(23): 3407-14.
Peto, R., J. Boreham, et al. (2000). "UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years." Lancet 355(9217): 1822.
Roche, H., L. Yelle, et al. (2007). "Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy." J Clin Oncol 25(23): 3415-20.
Vahdat, L.T. Phase III trial of ixabepilone plus capecitabine compared to capecitabine alone in patients with metastatic breast cancer (MBC) previously treated or resistant to an anthracycline and resistant to taxanes. Abstract - No. 1006, 2007 ASCO Annual Meeting.


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White Torture
"After I recanted my false confession, my main interrogator essentially told me he knew I was not a spy. My captors may have wanted to use my false confession to intimidate Iranians advocating better relations with the West. They may have also wanted my false confession to reinforce their claim that America had planted spies throughout Iran."
The Millions talks with Roxana Saberi, author of Between Two Worlds: My Life and Captivity in Iran, about her time in Evin prison, the Green Movement, and her transformation into a spokeswoman for human rights.


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Check out the latest RPG news | Podcasts | Twitch Streams
Got no idea about the DLC. I'd say it's worth moving on past the first world... but like we've all said, it's definitely a game that suffers from overcomplicating itself.
I wound up snagging this the other day. I love complicated systems for reverse engineering and my wife, for goodness knows what reason, finds the style of humor hilarious (either that or she enjoys watching my brain melt occasionally XD ). Did some research into the DLC if you're still wondering Klyde. It's nothing extensive but here's some baseline info:Lonely Goddess SetBlack Cat Ears Atk & Mnd 6%Black Eyepatch Agi 12%Noire's Clear Dress Def & Int 9%Noire's Clear Garter Int & Agi 9%Noire's Clear Boots Atk & Tec 9%CPU Candidate setBrain Controller Int & Tec 6%Purple Frames HP & Def 6%Nepgear Sailor Dress SP, Mnd & Tec 6%Pink Striped Band Atk & Agi 9%Nepgear Boots Def & Tec 9%Console Patron Unit setTwin brain Controller Def & Mnd 6%Toast Def 12%Neptune Hoodie Dress HP, Atk & Agi 6%Blue Striped Band Int & Tec 9%Neptune Shoes SP & Agi 9%First Generation Bride setWedding Headdress Agi & Tec 6%Chocolate Banana Atk 12%Fyuria's Top Armor At & Agi 9%Fyuria's Cross Belt Mnd & Tec 9%Fyuria's Metal Boots SP & Def 9%Overwhelming Goth Loli setFluorescent Ribbon SP & Tec 5%Stormy Eye SP & Int 6%Frilly Gothic Dress HP, Def, Mnd 5%, Tec 2%Frilly Gothic Skirt HP, Def & Mnd 5%, Tec 2% (same as dress)Monotone Heels Atk 2%, Mnd, Agi & Tec 5%Overwhelming Ready-made-clothing SetDumpling Ribbon HP & Def 5%Homemade Specs Tec 10%Fault Guard Int & Mnd 7%, Agi 3%Fault Skirt SP & Tec 4%, Mnd 9%Winged Fault Boots Mnd 8% Agi 9%Mugen Knight SetDecorative Ribbon Mnd 10%Cross Scar Agi 10%Armor Knight HP 3%, Atk & Def 7%Tiered Knight HP 9%, Def 8%Iron Knight Atk 8%, Def 9%Overwhelming Conquering SetPom Pom Beret Int & Tec 5%Prestige Makeup Mnd 10%Conquering Blazer HP & Atk 5%, Tec 7%Conquering Skirt Atk & Int 5%, Agi 7%Conquering Slip-ons SP & Agi 4%, Int 9%
Quote from: Tooker on December 28, 2012, 12:18:14 AMGot no idea about the DLC. I'd say it's worth moving on past the first world... but like we've all said, it's definitely a game that suffers from overcomplicating itself.Gave it some thought and time and.... strange as it maybe.... its absolutely horrid mechanics and systems are somehow becoming "comfortable" to me.... I'd go so far as to say "addicting".... in every objective way I can look at this game its just downright bad.... but I'm really starting to like it-LoLNone the less, I think I'm gonna polish off Hyperdimension MK2 before pouring my time into this... I don't want to burn myself out on compile hearts before I finish that and agarest 2.... Thank you for the advice took!


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Crisp's big-haired surprise
Recommended Video:
Coco Crisp got home and let down his hair. Literally. The center fielder played Thursday's game with a giant afro after taking down his braids earlier in the day.
Asked if he were planning to stick with his new 'do, Crisp said, "Yeah. I don't know what else to do with it. ... if I can get my shirt on."
Once he carefully pulled on his jersey and put his cap on - same size as always, he said - he ran onto the field for batting practice. To the amazement of teammates and manager Bob Geren, who said, "A little retro there."
Oscar Gamble-style. Gamble was the outfielder/designated hitter whose 17-year career included the entire 1970s, when he sported the game's most amazingly large afro. Like Crisp, Gamble was a relatively tiny player and hit 200 home runs (Crisp has 67 in his 10th season).
Why the change, Coco? "My head was itching," he said.
Reliever Grant Balfour suggested Crisp should do a commercial for Head & Shoulders shampoo like Steelers' safety Troy Polamalu.
Long-awaited triple: Mark Ellis was awarded a triple five days after he hit the ball.
On Saturday, Twins center fielder Denard Span was charged with a three-base error, and the A's appealed the ruling with MLB, which viewed the replay Tuesday and made the change Thursday.
"I'm 1-for-1 already," Ellis said before the game.
With 22 career triples, he's now tied with Sal Bando for eighth place on the Oakland list.
Briefly: Relievers Andrew Bailey and Michael Wuertz threw off bullpen mounds again, and Geren reported all went well. Wuertz is closer to heading for a minor-league rehab assignment ... Infielder Adam Rosales had a CAT scan in Los Angeles and said he was told his fractured foot is 90 percent healed and that he's 2-3 weeks from "being more vigorous" and running the bases.
E-mail John Shea at firstname.lastname@example.com.


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Google Ventures is investing in a company that studies traffic congestion software and ways to alleviate it, according to reports.
Urban Engines was founded by ex-Googlers and a Stanford professor, so it definitely has some Silicon Valley times, according to TechCrunch. The company uses algorithms and data from public transit to study congestion patterns and can give solutions to cities and commuters. Data is taken from swiped cards or tokens on public transit and then used to determine crowding, wait times and congestion. Already the company has partnered with World Bank, Washington, D.C's Metro system and Sao Paolo, Brazil. The amount of the investment wasn't disclosed.
Essentially this information can make cities and other local governments make better transportation planning decisions, but the software can be used to give commuters incentives to travel at less crowded times, according to Quartz. Riders could sign up for a program and get credit for riding at off hours or receive alerts when the transportation is at peak congestion, and the developers hope cities use this feature.
U.S. & World
Urban Engines isn't really a fun app, but more software that can be used to help city and urban planners create a congestion-free future. However the real change will be when employers decide that employees don't have to work an 8 a.m. to 5 p.m. day.


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Updated 11:55 a.m., 1/23/2014
(CNN) - Virginia's new Democratic leadership has declared the state's ban on same-sex marriage unconstitutional and won't defend it in federal lawsuits, illustrating how partisan shifts at the top can swiftly move the needle on hot button issues.
"It's time for the commonwealth to be on the right side of history and the right side of the law," state Attorney General Mark Herring said at a news conference.
Follow @politicalticker
Herring, a former state senator, stressed marriage equality as part of his campaign last year. His narrow election and Terry McAuliffe's victory as governor marked a major change in Virginia politics with Democrats replacing conservatives in top executive positions.
Former Virginia Attorney General, Republican Ken Cuccinelli, who lost the gubernatorial election, was a strong opponent of legalizing same-sex marriage.
Multiple lawsuits in Virginia charge that the Old Dominion's same-sex marriage ban violates the Constitution's equal protection and due process clauses.
The Democratic position rankles the GOP in Virginia, a so-called "purple state" where the general assembly is dominated by Republicans and policies on social values trend conservative.
"By running for the office, Mark Herring asked for the challenge of defending Virginia's constitution and all it contains," Republican Party of Virginia Chairman Pat Mullins said in a statement.
"If Mark Herring doesn't want to defend this case, he should resign, and let the General Assembly appoint someone who will. Mark Herring owes the people of Virginia no less," he added.
Partisan politics at the state level have helped shape the national debate on key issues, including same-sex marriage, abortion, gun rights, and voter identification.
Larry Sabato, director of the Center for Politics at the University of Virginia, said official positions in many areas can shift when party control of government changes.
"In this polarized political era, a great gulf separates the two parties on all the hot-button social issues," he said.
Reversal of the same-sex marriage ban in a crucial battleground state nationally follows court decisions striking down similar prohibitions in Utah and Oklahoma, states where Republicans dominate the legislature and the governor's office.
President Barack Obama won Virginia in 2008 and 2012 and lost Utah and Oklahoma in those same elections.
Fifty-seven percent of Virginians voted to approve the same-sex marriage ban in 2006. But recent polling indicates that a slight majority now support the right of gays and lesbians to marry.
"This lawlessness is an insult to the voters of Virginia who approved the marriage amendment by a large majority," said Tony Perkins, president of the Family Research Council. "The 'left' is becoming a law unto itself."
A state's hue makes a big difference on where it stands on issues like same-sex marriage, abortion, gun rights and voter identification laws. There are currently more Republican governors than Democrats and more Republican dominated legislatures.
For example, the 17 states and the District of Columbia that allow same sex-marriage are all considered Democratic-leaning "blue states." With a few exceptions, most states with a same-sex marriage ban tend to be Republican-leaning "red states."
Also, more than half of the nation's state legislatures introduced measures last year that sought to sidestep any potential federal ban on firearms, assault weapons and high-capacity ammunition magazines, according to data collected by the National Conference of State Legislatures.
Most of those were so-called "red states" with Republicans in charge of at least one chamber of the legislature and often governorships.
Moreover, several Republican-dominated states with a history of voter discrimination pressed forward with controversial voter identification laws after the Supreme Court struck down a key part of the Voting Rights Act.
And the strongest resistance to participating in insurance exchanges, a key component of Obama's signature health care reform law, came from states with Republican governors and GOP-led legislatures.
"This underlines how much elections matter," Sabato said.
Okay, let's take the right wing's argument that civil rights is a states' rights to its illogical conclusion.
1 – SCOTUS rules gay marriage bans are unconstitutional.
2 – State passes law banning gay marriage. State claims states' rights.
3 – City within state legalizing gay marriage within its' borders. City claims sovriegn rights.
4 – The Madison Heights neighborhood association passes rule banning same-sex couples from owning homes.
When does it end? Where do you draw the line, and who should draw it?
just saying
maybe all of the republican governors and attorney generals should also similarly unilaterally declare all gun control laws unconstitutional and stop enforcing them? no different that what the democrats are doing. if the democrats want anarchy then give them anarchy.
Republican Sheriff's are already using that tack. Republicans simply believe themselves above the law- and actively work to reduce the right of those that oppose them. Frankly, anarchy is what drives the anti-government TEA-Crazies.
naota channel
The people overwhelmingly voted to BAN "gay" marriage.
That should be the end of it.
What if "the people" voted to end you? Would that "end it"? Your rights and voting only go so far- like up to the point where you harm others. Your side has been unable to show how letting Gays have equal marriage rights affects anybody. Be honest- you just want to infringe on their civil rights- nothing more.
Conservative opposition used to be based on "harm". Harm to families, children, ect... We have same sex marriage in a huge swath of the country. So where is the harm? How are traditional marriages in any impacted? How is religious freedom abridged when the State issues a marriage license? Unless of course you believe the State and the Church are the same thing. Same sex marriage is a done deal. The Supreme Court will eventually overturn bans if for no other reason than to end the designation of rights for a minority group based on the political balance of power in a particular state. With gays free to marry in most Democratic leaning states, it's clear that bans are no longer a value shared by the culture at large but is instead a worldview based on whether you watch Fox News or not.


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9 Things Hawaii Chefs Wished You Knew
(page 1 of 4)
The restaurant world from Honolulu to Hoboken was riled up when, in 2009, The New York Times published a column titled "100 Things Restaurant Staffers Should Never Do." It was like an emancipation proclamation for people who give their money to eateries: "Never refuse to seat three guests because a fourth has not yet arrived," "do not interrupt a conversation—especially not to recite specials," "never say 'I don't know' to any question without following with, 'I'll find out.'" Cooks, restaurant owners, critics and eaters let comments fly on Twitter—"Hurrah!" or "He's never been a server"—and at least one Honolulu restaurateur tacked them up in the kitchen.
Is the customer always right? We turned the tables and asked Hawaii chefs to dish on what they wish diners knew.
#1 Reservation protocol
"The best time to dine is early or late in the evening," says Johann Svensson, chef de cuisine of BLT Steak. "It's easier to get a table, and there are fewer people—so less hassle. Service is on time at those times." On a Friday night, what's a good time to snag prime real estate at BLT Steak? "Nine o'clock," he says.
Chef after chef cited boors who try to name-drop and elbow their way to star treatment. Jon Matsubara, chef de cuisine at Azure, wants you to know that "the proverbial 'you attract more flies with honey than vinegar' will always work better in your favor. Everybody, regardless of industry, likes to accommodate people who are polite."
If you have a habit of making multiple reservations at multiple restaurants, and then choose where you want to go the night of, don't think you're getting the last laugh. An online database called Open Table lets restaurants track all sorts of stuff. Birthdays, favorite dishes, number of times visited, and other notes. The industry is small, so if you make a habit of shafting reservations, they'll know sooner or later.
"I wish people knew what happens when they 'no show' on a reservation or cancel at the last minute," says Paul Feng, chef de cuisine at Chef Mavro. "The obvious is that somebody who wanted that table or that time is mad. Also, it means we throw food away that local farmers have gone to a lot of trouble to grow and deliver to us. And staff get sent home early and make less money.
#2 Know your sauce
Pasta is practically its own food group in the U.S., yet people know surprisingly little about the intricacies of this Italian staple, says Keith Endo, chef de cuisine at Vino.
Endo makes his own pasta and, for him, there are few things more disheartening than people complaining that there's not enough sauce atop his handcrafted noodles. "I wish people knew that pasta is supposed to be very simple. I ask the servers to let them know it's not about the sauce. Of course, you can have more sauce if you want, but, really, it's about the flavor and texture of the pasta." Endo notes how he changes the ratios of semolina flour, water, salt and sometimes egg to suit the many types of pasta he makes, and dreams of people appreciating the subtle differences.
Even though Thai food is one of the most prevalent cuisines on the island, Kenny Usamanont, sous chef and owner of Haleiwa Eats and Rajanee Thai Cuisine in Mililani, still has to explain the difference between red, green and yellow curry. For the record, "It all comes down to the chiles," he says. "The red are dehydrated chiles and the green are fresh, and yellow is turmeric inspired. Even if we make curries mild, the green is always spicier because it's fresh."


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Genelec have announced that they will be releasing a new series of affordable, yet high-quality studio monitors. The M030 and M040 have been specifically designed for home-studio owners, DJs, and semi-professional producers. Their compact size also makes them ideal for producers that need a portable production option and they feature automatic voltage selection so are great if you're crossing continents.
Tag Archives: genelec m040
Posted on April 10, 2013 by Joe Stachowiak
This post was posted in Computer Music, General News, New Releases, Product News, Recording and was tagged with active monitor, genelec, genelec m030, genelec m040, musikmesse, musikmesse 2013, studio monitor
Posted on April 10, 2013 by Joe Stachowiak
It's time for another Musikmesse show in Frankfurt and so far we've already been treated to a host of exciting new releases! We will be constantly updating this article with information on the most exciting news from the show and will include links for you to find out more information on specific products where possible. So, if you want to keep up to date with all the latest Musikmesse 2013 news, this is the place to be!
This post was posted in Blog entries, Computer Music, Drums, General News, iOS Devices & Apps, Keyboards & Synths, Live Sound and Light, New Releases, Product News, Product Previews, Recording and was tagged with active monitor, allen & heath, allen & heath qu-16, analogue synth, arturia, arturia keylab, avid, avid pro tools 11, bass station, bass station ii, digital mixer, digital piano, genelec, genelec m030, genelec m040, harmony singer, Korg, korg kross, korg kross 61, korg kross 88, korg lp280, korg volca, korg volca bass, korg volca beats, korg volca lead, Launchpad, launchpad s, lp380, magneto, musikmesse, musikmesse 2013, nord, nord drum, nord drum 2, nord drum pad, nord lead, nord lead 4, nord piano 2 hp, Novation, novation bass station ii, novation launchpad, novation launchpad s, pro tools, pro tools 11, qu-16, se electronics, se electronics magneto, studio monitor, tc helicon, tc-helicon harmony singer, universal audio, universal audio apollo, universal audio apollo 16, vocal pedal, workstation keyboard


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Friday, 16 April 2010 05:23 PM
In the face of stiff GOP opposition, Obama administration officials want Senate Democrats to purge a $50 billion fund for dismantling "too big to fail" banks from legislation that aims to protect against a new financial crisis. Republicans contend the provision would simply continue government bailouts of Wall Street.
The sweeping bill aims to prevent a recurrence of the crisis that nearly caused a Wall Street meltdown in 2008. Beside creating a mechanism for liquidating large firms, House and Senate bills would govern previously unregulated derivatives, create a council to detect systemwide financial threats and establish a consumer protection agency to police lending, credit cards and other bank-customer transactions.
President Barack Obama declared Friday that he would veto the bill if it doesn't regulate the freewheeling derivatives market. "We can't afford another AIG," the president said, referring to the giant insurance conglomerate that relied heavily on the complex, sometimes exotic investment instruments.
Separately on Friday, the government accused Goldman Sachs & Co., Wall Street's most powerful firm, of defrauding investors by failing to disclose conflicts of interest in mortgage investments it sold as the housing market was collapsing two years ago.
One senior Treasury official said Friday that the fund for dismantling giant failing banks, which would be financed by large financial institutions themselves, is unnecessary. He said the costs of dismantling the firms could be recouped from the industry after a liquidation.
If the chairman of the Senate Banking Committee, Christopher Dodd, D-Conn., complies, that would remove one component of the bill that Republicans have persistently used to rally opposition. But it was unclear whether that step alone would yield any Republican votes.
Senate Republicans stood solidly against the bill Friday after GOP leader Mitch McConnell persuaded Susan Collins, R-Maine, to join 40 fellow lawmakers in expressing their opposition and demanding further negotiation.
The legislation would for the first time regulate derivatives, the instruments such as mortgage-backed securities that contributed to the near meltdown when their value plummeted during the housing crisis.
Obama said he wants derivatives to be strongly regulated, and he added that he's ready to veto any financial regulation bill that comes to his desk without it.
But there's some dispute among Democrats about how far such regulation should go.
And the unified Republican opposition strengthened the hand of their Senate leader, McConnell of Kentucky, as Democrats prepare to bring the legislation to the floor for debate. The majority Democrats had been hunting for individual Republicans to peel away from their party caucus to help gain the 60 votes that would be needed to overcome a likely GOP procedural roadblock.
"We are united in our opposition to the partisan legislation reported by the Senate Banking Committee," the Republicans said in a letter to Senate Majority Leader Harry Reid, D-Nev.
McConnell has portrayed the legislation as a continuation of bailouts and as a partisan measure heavily influenced by the White House.
But the most contentious provision, the $50 billion fund, was the result of bipartisan negotiations between Banking Committee members Mark Warner, D-Va., and Bob Corker, R-Tenn.
On Thursday, Corker, too, suggested that given the furor, Democrats should simply drop the fund from the bill.
The argument for paying up front for liquidation costs of a failed big bank is that it would reduce the amount the Federal Deposit Insurance Corp. would have to borrow from the Treasury Department to dismantle large firms. But the administration has said all those costs could be recouped from the financial industry after the fact without keeping taxpayers on the hook for the expense.
Also on Friday, the chairwoman of the Senate Agriculture Committee, Sen. Blanche Lincoln, D-Ark., issued her version of derivatives legislation — a proposal that goes beyond the pending banking bill by requiring large banks to spin off their derivatives trading operations.
That provision would especially hit banks such as Goldman Sachs and JPMorgan Chase, and bank lobbyists said they were prepared to fight it.
The Treasury official said the administration preferred language in the Senate Banking Committee bill that would restrict overall proprietary trading by large banks, not just derivatives trades. That provision, however, would require a council of regulators to first study how to implement such a regulation. Lincoln's proposal is more specific.
The Treasury official spoke on condition of anonymity to describe positions the White House was not ready to take publicly.
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The EM Original Necklace
Wine on Black Cord
Regular price $150.00
Resin bead necklace, hand knotted on cotton cord. Silver tag. Matte finish, smooth to the touch, light weight. Slips over the neck, no clasp. Measures approximately 42 inches long (hangs to the navel). Can be worn doubled. Best layered in pairs—mix, match, mismatch.
Curious to see how it'll hang on you? The model (in the black and white photo) is 5' 6" and she's here to give you an idea of the scale.


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You've found your best source for information on the life, work, and legacy of Elvis Presley, the 20th Century's greatest cultural icon. Through the use of eyewitness accounts, classic photos, and historical analysis, a clear and accurate picture of the King of Rock 'n' Roll comes into focus.
Blog entries will be posted the first and third Thursdays of each month. The goal is to present accurate and new historical information about Elvis. When needed, myths, half-truths, and rumors that have been spread through the years will be exposed. In addition to the blog and its archives, this site offers a dozen other gateways to information on the life and career of rock 'n' roll's most exciting pioneer.
The contribution of visitors to this site is welcome. If you have access to accurate information about Presley, please contact me using the link below. If you see something on this site that you know to be inaccurate, let me know, and we'll set the record straight. Together we can clarify and add to the legacy of the phenomenon that was and is Elvis Presley. | Alan Hanson
Books by Alan Hanson
Click on Cover Image for Purchase Information


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Charlie Strong says he's excited to take over at Texas
Charlie Strong said Sunday he is excited to be the new head coach at the University of Texas, citing the Longhorns' history and tradition in college football.
"I'm excited and my family is excited to have the chance to lead one of the premier football programs in the country," Strong, who was 37-15 at Louisville, including 12-1 this year, said in a statement. "Texas is one of those places that is always on your radar and a program anyone would dream of being a part of because you have a chance to compete on a national level every year."
Athletic director Steve Patterson said in the university's announcement that Strong will be introduced at a Monday news conference.
Per his contract, Strong will owe Louisville $4.375 million, with that amount due within 21 days of his final day of employment.
"I am excited to have Charlie Strong here to build on the proud tradition of Texas football and the 16 great years that Mack Brown gave to the program;" Patterson said.
Brown resigned last month after 16 seasons at Texas. The Longhorns finished 8-5 with a 30-7 loss Monday to Oregon in the Alamo Bowl. Although the Longhorns won a BCS national championship and played for another, the program slipped precipitously in the last four seasons. They were 4-16 in their last 20 games against ranked opponents.
"To follow a future Hall of Fame coach like Mack Brown, who built a program that had great success and a reputation of doing it with class and integrity, is extra special," Strong said. "The national championship, BCS bowl wins and all he accomplished in 16 years built on the Longhorn legacy and makes it such an exciting place to be."
Strong, 53, a native of Batesville, Ark., made his reputation as a defensive coordinator at Florida. Last season, he coached Louisville to a victory over the Gators in the Sugar Bowl. This year, the Cardinals won 12 games including the Russell Athletic Bowl, a 36-9 win over Miami.
"This was a difficult decision because the University of Louisville gave me my first opportunity as a head coach," Strong said. "I have so much respect for President (James) Ramsey and (athletics director) Tom Jurich. They have been great to me and my family, and it was very hard to say goodbye, but they know this was an opportunity I couldn't pass up."
Strong told The Coureri-Journal in Louisville that he had spoken to "a large amount" of Cardinals players over the phone, and that "some were happy and some were upset, because they wanted to play for the coach who recruited them."
"It's really tough on me," Strong told the Courier-Journal. "It's tough because I recruited them and I don't want anything but the best for them. It's hard for me. It's one of the hardest decisions I've ever made.
"I know there's some hard feelings, and that's what I didn't want is hard feelings. I just don't want them to feel like 'Coach Strong ran out on us.' Some people are going to feel like that, but I don't want that feeling."
In the aftermath of Strong's decision to leave Louisville, at least two Cardinals recruits have said they no longer plan to attend U of L. Strong encouraged U of L pledges to remain firm in their commitments, though he understood their position.
"It's all about the university; it's not about the coach," he said. "I think a lot of those guys from Florida felt like it was a Florida connection, but those players were picking a university, too…They're not there for me, they're there for the university and all it has to offer."
Sports Illustrated reported Strong had been offered a five-year contract worth $5 million a year.
Contributing: Adam Himmelsbach of The Courier-Journal.


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THROUGH the capture of and subsequent announcement that it would release 15 British sailors and marines, the Islamic Republic of Iran sent its adversaries a pointed message: just as Iran will meet confrontation with confrontation, it will respond to what it perceives as flexibility with pragmatism. This message is worth heeding as the United States and Iran seem to be moving inexorably toward conflict.
The timing of the Britons' capture was no accident. The incident followed the passage of a United Nations resolution censuring Iran for its nuclear infractions, the dispatch of American aircraft carriers to the Persian Gulf and the American sanctioning of Iranian banks. Although the Bush administration has been busy proclaiming its increasingly confrontational Iran policy a success, Tehran's unsubtle conduct in the Persian Gulf suggests otherwise.
Had the British followed the American example, once the sailors and marines were seized, they could have escalated the conflict by pursuing the matter more forcefully at the United Nations or sending additional naval vessels to the area. Instead, the British tempered their rhetoric and insisted that diplomacy was the only means of resolving the conflict. The Iranians received this as pragmatism on London's part and responded in kind.
The United States, meanwhile, has pursued its policy of coercion for two months now, and one is hard-pressed to find evidence of success. Beyond even the symbolic move of apprehending the British sailors, Iran's intransigent position on the nuclear issue remains unchanged. To underscore that point, Iran has scaled back cooperation with the International Atomic Energy Agency and released a new currency note adorned with a nuclear emblem.
Moreover, although Iran has proved willing to talk to Saudi Arabia, especially regarding Lebanon, it has yielded no new ground. In fact, Saudi Arabia's concerns, relayed to Iran's chief nuclear negotiator, Ali Larijani, during his visit to Riyadh in January, went unanswered. And if the March 10 meeting of neighbors in Baghdad was supposed to bring a chastened Iran to the table, the opposite happened. Far from being accommodating, Iran boldly asked for a timetable for the withdrawal of American troops from Iraq. But the meeting was noteworthy in making a show of Iran's regional influence and its importance to the future of Iraq.
The United States faces a stark choice: it will have to either escalate its confrontational policy or adopt a policy of engagement. Far from arresting the Iranian danger, escalation would most likely present the United States with new perils. Given the balance of power in the region, a continued confrontational course with Iran would saddle the United States with a commitment to staying in the Persian Gulf indefinitely and deploying to other conflict areas in an environment of growing radicalism. It would place the United States at the heart of the region's conflicts, leaving it all the more vulnerable to ideological extremism and terrorism at home and abroad.
Beyond such concerns, a continued policy of confrontation will also complicate America's Iraq policy. Just as Iraqi Sunnis have cultural and political ties with Sunni Arab states and look to them for support, Iraqi Shiites trust and depend on Iran. An Iraq policy that allies the United States with Sunni Arab governments to eliminate Iranian influence in Iraq will be construed as biased against the Shiites. Such a policy will not win the support of the Shiite-dominated government on which the success of the new American strategy depends.
Since the United States entered Iraq in 2003, Washington has complained about Iran's meddling, and about its involvement with radical groups and militias. Still, Iran, far more than any of the Sunni Arab regimes, has also supported the Shiite-dominated government and the Iraqi political process that brought it to power. If Iraq were to exclude Iran and seek to diminish its regional influence, Iran would have no further vested interest in the Iraqi political process, and it could play a far more destabilizing role. Therefore, the current policy will not reduce the Iranian threat to Iraq but rather increase it.
An American conflict with Iran would also undermine regional stability, jeopardize the economic gains of the Persian Gulf emirates and inflame Muslim public opinion. Persistent clashes with the United States will radicalize the Iranian theocracy and, more important, the Iranian public.
Iran today sees regional stability in its interest. It abandoned the goal of exporting its revolution to its Persian Gulf neighbors at the end of 1980s and has since acted as a status-quo power. It seeks influence within the existing regional power structure. It improved its relations with its Persian Gulf neighbors throughout the 1990s, and in particular normalized relations with Saudi Arabia. Iran supported the stabilization of Afghanistan in 2001 and that of Iraq during the early phase of the occupation. Conflict will change the direction that Iranian foreign policy has been following, and this will be a change for the worse and for the more confrontational.
A judicious engagement policy will require patience and must begin with a fundamental shift in the style and content of American diplomacy. The breakthrough in American-Chinese relations during the Nixon administration followed such a course. Beijing responded favorably to engagement only after two years of unilateral American gestures. As part of a similar effort toward Iran, the Unites States should try to create a more suitable environment for diplomacy by taking actions that gradually breach the walls of mistrust.
Washington can begin by ending its provocative naval deployments in the Persian Gulf, easing its efforts to get European and Asian banks to divest from Iran and inviting Iranian representatives to all regional and international conferences dealing with the Middle East. Along this path, the language of American diplomacy would also have to alter. The administration cannot propose negotiations while castigating Iran as part of an "axis of evil" or the "central banker of terrorism" and forming a regional alliance to roll back Iranian influence.
Once a more suitable environment has been created, the United States should propose dialogue without conditions with the aim of normalizing relations. For too long, proposed talks with Iran have focused on areas of American concern: nuclear proliferation and Iraq. A more comprehensive platform would involve the totality of disagreements between the two countries and also address Iran's regional interests.
On the nuclear issue, Iran would have to accede to a rigorous inspection regime to make certain that its nuclear material would not be diverted for military purposes. In the meantime, more cooperative relations between the two parties could benefit stability in Iraq, where both Tehran and Washington support the same Shiite-led government.
After 28 years of sanctions and containment, it is time to accept that pressure has not tempered Iran's behavior. The announced release of the British captives shows that the Islamic Republic is still willing to mitigate its ideology with pragmatism. A policy of patient engagement will change the context, and that may lead Iran to see relations with America to be in its own interest. Only then will Tehran chart a new course at home and abroad.


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Living Her Teenage Dream, Katy Perry Rocks the World Over with Sennheiser
FOH engineer Pete Keppler and monitor engineer (Super) Dave Rupsch rely on Sennheiser equipment to deliver Perry's performance in all its sonic resplendence.
By: Hummingbird Media
Perry and both of her backing singers use Sennheiser SKM 5200 wireless handheld transmitters with MD 5235 dynamic capsules, a capsule that is based on Sennheiser's legendary e 935 vocal mic. "In anticipation of the new album we tried loads of different live vocal mics," said Rupsch. "The MD 5235 stood out. It has a flat, natural response with nice hint of coloration. With it, Katy's voice is clear and present with a balanced high end that never comes across as too sharp or crisp. Because the backing singers are using the same capsule, we get an excellent vocal blend in our personal monitors and in the house. And that's exactly what Katy, Pete, and I need."
Rupsch delivers those vocals, along with everything else in the mix, to all eight musicians on stage and two techs using Sennheiser ew 300 IEM G3 wireless personal monitors. "Everyone is in love with the sound of the new G3s," he said. "They're clean, responsive and dynamic. There are no sonic improprieties to work around, and as a result, this is the most straightforward wireless personal monitor mixing I've ever done."
Although he has worked FOH for bands like All American Rejects, My Chemical Romance, and 3OH!3, Rupsch is equally comfortable behind the monitor desk and appreciates the advances in wireless technology pioneered by Sennheiser. "With the wireless vocal mics, a few Sennheiser ew 500 G3 wireless instrument packs, and all of our monitor channels, I've got close to twenty frequencies to manage," he said. "I'm running the Sennheiser Wireless Frequency Manager software, which makes the setup reliable and easy. Dialing the whole system in is fast, and I have yet to experience any wireless glitches. And I don't anticipate it."
In contrast to most American artists, Rupsch estimates that less than half of Katy Perry's shows are in the U.S., which means that he and the crew find themselves in exotic locations – with equally exotic RF landscapes – more often than not. "A huge part of our decision to go with Sennheiser is its robust RF performance and its network of global support," said Rupsch. "The Global Relations Team and support network at Sennheiser are always there with anything we need, from parts, to gear, to up-to-the-minute frequency ranges anywhere in the world. No matter where we are, be it the Teen Choice Awards or Kuala Lumpur, Sennheiser is there for us."
In addition to their Sennheiser wireless complement, the tour also travels with a wired microphone collection that's brimming with Sennheiser's celebrated evolution series. Sennheiser e 902 large-diaphragm dynamics give the kick drum and floor tom a fitting "WHUMP!" with e 604 clip-on mics delivering the same for the rack toms. Sennheiser e 614 and e 914 small-diaphragm condensers provide crystal clear capture of the hi-hat, ride and overheads. Classic Sennheiser e 906 square dynamics deliver guitars with all the right nuance and crunch. A second set of e 914s provides audience pickup so that Rupsch can goose the personal monitor mixes with the fans' excitement, which consistently snowballs an energetic performance into an explosive one night after night.
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Tips for running a successful European project
There is no general list of ingredients or advice that can guarantee the success of a project, no matter how closely it is managed. Risks exist, and issues that were not envisaged may arise, affecting the project's outcome. Project teams need to pay attention to project execution in order to deliver expected results. That's what project management is all about. Here are some simple tips that, in our experience, are helpful in running a project that delivers on its promises, both in the proposal phase, and during the project lifecycle.
1. Assign the right people to the right job
This advice might sound self-evident, but it is not necessary followed by project teams.
The first level of 'right people' is the consortium/overall project team itself. Are the right partners included in the consortium? Can everyone deliver on their promises? These questions are basic but critical, since they will determine, in large part, both the success of the proposal and whether the project delivers on its promises, on time and within budget, which is in fact the most important criterion for the success of a project.
The 'right partners' can take many forms. The consortium can include partners that have strong research output capabilities, or someone who offers access to a unique network or, finally, someone who has the appropriate stakeholder backing. It is the responsibility of the project manager to identify all the necessary requirements of the project (either stated or in the background) to the fullest extent possible and try to create the adequate consortium.
Additionally, the right people need to be assigned for the right tasks. It is not perhaps best for a project to include only senior people with large experience, since they tend to have very little time available. People at the correct level of experience with the ability to dedicate significant time to the project are also needed.
It is almost certain that there will be a requirement for unscheduled work, so including team members with some scheduling flexibility is also important.
2. Ensure excellent and efficient internal communication
Full and timely communication with, and between, the project team members is crucial, and will increase mutual trust and the understanding of what's expected of each team member, which increases the likelihood of on-time task completion.
The same can be said for communication between project partners. Proactive communication is needed to maintain interest in projects by the whole consortium as well as to ensure that all issues are identified and solved, and avoid major issues just before the final deliverable deadline.
It is also important to ensure effective communication with the EC Project Officer. Important issues related to the project, for example financial problems, delays in delivering the expected results etc., should be communicated to the EC Project Officer in a timely manner. This will help the project team to find solutions for the problems at hand, and thus allow for the continuation and finalisation of the on-going project. The EC Project Office is effectively part of the team and must be treated as such.
3. Be prepared to address unexpected issues
Hope for the best, but prepare for the … unexpected! It is a rarity to not run into obstacles and unexpected situations during a project lifecycle. Very often, things don't go exactly as planned and we can't anticipate any totally unexpected hurdles that might come our way, even if the critical risks for implementation were carefully thought out and defined. That's why it is wise to consider things from all angles and have a plan for backup measures.
Knowing about possible risks is, in itself, insufficient. It is important that project managers develop an effective response plan, have access to the required resources (money, manpower …), and have the authority to ensure that the necessary action is taken.
These issues are usually considered when addressing the risk management plan, which is composed of three main aspects:
- Risk analysis - identification, classification, and assessment of risks;
- Risk mitigation plan - documented plan for addressing key risks;
- Risk monitoring - ongoing reporting of progress and impact of anticipated areas of risk.
4. Be critical
There is a lot of competition for EC grants. Success is certainly not guaranteed. But there are valuable lessons to be learned from unsuccessful proposals. Documenting what went wrong and what was needed can be glimpsed from the evaluation as well as from the winning project proposal (what did they have that you didn't?).
In the same way, use the project reviews as a test bed for your running of the project. Compare what you were criticized for against your procedures. Perhaps that will enable you to improve all your projects, and not just the one that you are running. It is important in a project to have timely reviews, so if the required EC reviews are perhaps not sufficient, why not introduce inter-consortium ones? This is particularly useful for projects that produce a lot of results that require critical acceptance before moving forward. Having partners reviewing the deliverables is very good, but perhaps a full day internal review is even better to really point out any issues.
In conclusion, we can consider that a project is a success if it delivers on all agreed project objectives, be they scope, schedule, budget, results quality or outcomes. Running a project in a smart and structured way, leading to success, is not an easy task. There are lots of rules and tips that can be applied, including, but certainly not limited to, the above. However, every project is different, and every project manager has a unique way of working. What is essential is to find the method that works best for you and your project, and incorporate it into your project management planning!
ESF has coordinated over 20 high profile EC projects (From FP6 to H2020) and can provide support in your proposal preparation and overall project management. Learn more about ESF's European Projects Coordination Support.
EC projects can be frustrating but they DON'T have to be if approached the right way.
Consider that you are leading a multinational effort that will add a piece of knowledge to the European community. Despite the issues, it is a unique and valuable experience.
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