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by Michael Caruso
Lyric Fest joined the bandwagon of the Philadelphia International Festival of the Arts and presented "Stranger Things: Paris in the Early 20th Century" Sunday, April 10. The concert took place in the First Presbyterian Church of Philadelphia at 21st and Walnut Streets.
Three West Mt. Airy musicians were at the very heart of the program. Pianist Laura Ward and soprano Randi Marrazzo (along with mezzo Suzanne DuPlantis of East Falls) are the founding members of the ensemble. Ward and Marrazzo were joined by baritone Randall Scarlata for a program of classical and popular songs. The concert charmingly caught the spirit of daring innovation that coursed through France's "City of Lights" as the romantic 19th century turned into the modern 20th.
The roster of composers performed included Claude Debussy, Francis Poulenc, Igor Stravinsky, Maurice Ravel, Erik Satie, Kurt Weill, Cole Porter, and George and Ira Gershwin.
Ward partnered Marrazzo and flutist Lois Herbine in two lovely songs by Delage every bit as memorably as she entered into the high-camp world of soprano Manon Strauss Evrard in numbers by Poulenc, Satie, Weill and Roussel. Evrard's flair for the over-the-top theatrical flash was a delightful addition to the program.
Sad to report, this concert was announced as the final one given in First Presbyterian Church. Most of next season's concerts will be given in the Warden Theater of the Academy of Vocal Arts at 1920 Spruce St. First Presbyterian Church is an architectural gem of Norman Revival style, its stained glass windows and gracefully arching brickwork are superb, as are its acoustics and Paderewski-owned Steinway concert grand. And its pews are comfortable, to boot! AVA's Warden Theater is cramped, stuffy, and uncomfortable — and there's not an acceptable concert-level piano in the entire building. If this move doesn't rate as suicidal, I don't know what does.
David Hayes and the Philadelphia Singers marked Holy Week with performances of Johann Sebastian Bach's Cantata No. 182: "Himmelskonig, set willkommen" (King of Heaven, Be Welcomed) and James MacMillan's "Seven Last Words from the Cross." The concert took place on Saturday, April 16, in the Episcopal Church of the Holy Trinity on Rittenhouse Square. Despite the truly horrific weather outside, a sizable and enthusiastic audience filled the Victorian-Romanesque masterpiece, with far more than a handful of on-the-spot ticket purchsers adding to the choir's season subscribers.
Born in 1959, MacMillan composed his "Seven Last Words from the Cross" between 1993 and 1994, incorporating into the seven phrases Jesus Christ uttered from the cross as found in the Gospels of Luke, John and Matthew several additional excerpts. All of the texts come together in the Scottish composer's hands to form a musical setting that is far more dramatic in its narrative and visceral in its emotional delineation than is the norm in most composers' settings of the Seven Last Words from the Cross.
It's a major work from one of contemporary classical music's most deservedly acclaimed masters.
Hayes and the Singers gave "Seven Last Words from the Cross" a sterling rendition Saturday evening. Pitch was immaculate, even in the face of daunting harmonies and textures, and diction was excellent so that the text was able to make its heart-rending impact on the listener as it is made even more potent through MacMillan's superb score. Hayes was equally efficacious leading the string ensemble.
He and the Singers were less effective in the Bach. Here the choral textures were so thick and undifferentiated that Bach's sublime counterpoint was rendered murky, at best, and sometimes completely indecipherable. Matters were only made worse by terribly slow tempi throughout. The two highpoints in the performance were Alyson Harvey's solo singing in "Leget euch dem Heiland uter" (Prostrate yourselves before the Savior) and flautist Sonora Slocum's obligato accompaniment of her. Harvey is a resident of West Mt. Airy and a longtime soloist at the Episcopal Church of St. Martin-in-the-Fields in Chestnut Hill. Organist Michael Stairs and cellist Vivian Barton Dozer offered exemplary continuo support.
West Mt. Airy's Jeri Lynne Johnson will lead the Black Pearl Chamber Orchestra in "Paris, When it Sizzled: Stravinsky, Milhaud and 'Le Jazz Jot.'" The concert is set for 7:30 p.m., Thursday, April 28, in the Independence Seaport Museum at Penn's Landing along the Delaware River. The program includes Darius Milhaud's groundbreaking "Le creation du monde" (The Creation of the World), one of the first European classical works to utilize American Jazz as an integral part of its musical language, and Igor Stravinsky's "Octet for Wind Instruments and Ragtime for 11 Instruments." The concert is part of the Philadelphia International Festival of the Arts.
For ticket information, call 215-546-PIFA or visit www.blackpearlco.org.


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Home › Classroom Resources › Lesson Plans
Lesson Plan
Swish! Pow! Whack! Teaching Onomatopoeia Through Sports Poetry
|6 – 8
|Lesson Plan Type
|Standard Lesson
|Estimated Time
|Four 50-minute sessions
|Lesson Author
Normal, Illinois
Normal, Illinois
Students explore different poems written about sports by reading and listening, looking closely at the use of onomatopoeia in each piece. After a discussion of the poems, students view a segment of a sporting event and generate a list of sounds used in that event. Using their lists as a springboard, students then create their own onomatopoeic sports poems, draw accompanying illustrations, and compile their work in a flip book. Finally, students present their flip books to the class.
Sports Poetry Flip Book Project: This handout provides guidelines for students for writing and illustrating a flip book containing an original sports poem.
Flip Book: Students can publish their work using this online tool, which allows them to type and illustrate tabbed flip books up to ten pages long.
In his book Boy Writers: Reclaiming Their Voices, Ralph Fletcher notes that male students are often disengaged and disenfranchised in the writing classroom. He believes that boys "get an unfriendly response from their teachers when they try to write about high-interest boy topics," which, according to Fletcher's research, include "teams, sports, and the confidence they get from sports" and "activity with their fathers [such as] sporting events." Giving them the choice to write about such topics can create an environment that will engage male writers.
Additionally, Fletcher believes that we can further engage male students by incorporating drawing into writing activities. Brain research shows that girls' brains are more verbal, whereas boys are more spatial. Fletcher notes, "allowing boys to draw while writing will make it more fun and help them feel invested."
Further Reading
Fletcher, Ralph. Boy Writers: Reclaiming Their Voices. Portland, ME: Stenhouse, 2006.
Newkirk, Thomas. "Misreading Masculinity: Speculations on the Great Gender Gap in Writing." Language Arts 77.4 (March 2000): 294-300.

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We both complain that young people today talk too fast or swallow their words or don't look at us when they speak. And we have difficulty in large groups where there are multiple conversations and different voices and background sounds.
I manage through paying close attention, even straining, when people speak, or relying on context to help me understand words I do not hear clearly. My husband wears hearing aids but finds that they mostly increase the volume of sounds, not the clarity. He also complains that they are irritating and uncomfortable when worn for several hours. That's why he takes them off when he's home, to "give his ears a rest." This decreases the physical strain for him, but increases the strain on our conversations: We sometimes find ourselves arguing over words that neither one of us heard right or even said!
We rarely go to movies any more because it's too difficult for both of us in different ways. He misses key words in the dialogue -- women's and children's voices are a special problem because of their high frequency -- and keeps turning to me to ask "What did they say?" If I try to answer him, I miss some of the dialogue myself and also annoy the people who are sitting nearby.
We also try to limit our group involvements ever since a recent uncomfortable experience. We were at a dinner party with some friends when someone told a funny story, and everyone was laughing in response -- except my husband. He just sat there in silence with a stricken look on his face because he could not hear the punch line.
It is estimated that about 1 out of every 10 people will experience some kind of hearing problem during the course of their lives, and that the number of people affected and the severity of their problems will increase the older they are.
It is also acknowledged that hearing loss is usually regarded with less seriousness or sympathy than other kinds of physical handicap -- and, in fact, has sometimes even been the butt of humor.
I think there may be several reasons for this.
Perhaps it is because hearing loss usually develops over time; there is no particular dramatic event that draws attention to it. Because it creeps in so slowly, friends and relatives may not realize what is happening.
Or perhaps, because the loss is gradual and invisible, people can -- and often do -- mask it or deny it. So how can people be sympathetic toward something they don't even know exists?
Or perhaps because hearing loss has become so associated with older people, it has come to be considered an acceptable part of the aging process.
But hearing loss is a genuine and serious loss, not a mere inconvenience. It means the loss of sounds of music and words of poetry or wit or wisdom -- and the loss of easy conversations and communications with others.
And it brings with it a sense of exclusion and isolation, leaving a person in a silent and lonely place.
What is needed is not so much sympathy but realistic understanding and accommodation. When you speak, you don't have to raise your voice, just speak slowly and clearly, and look at us so we can read your nonverbal communication as well as hear your words.
Check unobtrusively to see whether we are hearing you well enough, and, if not, repeat some words without fuss. Remember that we really want to hear your words as much as you want your words to be heard.
Still, my husband and I do have one advantage that others with hearing problems may not. We have been married for so long and know each other so well that, by this time, even when we can't hear each other's words, we can usually read each other's minds!
Lillian Hawthorne is a retired clinical social worker and emeritus faculty member of the School of Social Work at USC. She lives in Leisure Village, a retirement community in Camarillo.
My Turn is a forum for readers to recount an experience related to health or fitness. Submissions should be no more than 500 words. They are subject to editing and condensation and become the property of The Times. Please e-mail email@example.com. Although we read every essay, we can't respond to every writer.


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3 Share About Surya Baby Surya baby works at Vmoksha Technologies as a Digital Marketing Executive. She is passionate about exploring Digital marketing trends. Apart from work, she likes listening music and sketching. View all posts by Surya Baby Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Name * Email * Website Comment You may use these HTML tags and attributes:   <acronym title="">
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Because there is a lot of pictures they are in links so as not to cause slow loading.
The places of each player:
1st: Dr Lukas (36 points)
2nd: Captain Remle (33 points)
3rd: Sheriff Texan: (32 points)
Last: Aurther Wiltlow: (died on round 6)
The sign up thread
Round 0
Town Overwatch
Aurther started out on the south side of the bridge.
Lukas started out at the docks.
Texan started in town
Remle started outside of town.
Round 1
In this round the first boss enemy appeared, a white super zombie.
Aurther walked onto the bridge and peeked through the arks.
Lukas missed his attack and got swarmed by a couple of skeletons.
Texan approached the town center.
Remle walked over to the box by the gate and found a hatchet. He decided to use the lid as a shield.
Round 2
In a stroke of bad luck for the players, the second boss enemy got spawned this round.
Aurther snuck behind the super Zombie and put a knife to its throat. The skeletons came over to attack as the super zombie turned around.
Lukas had run towards the dome to get away from the skeletons.
Texan The sheriff hid behind the car in town.
Remle walked south.
The peach squad got ready to fight.
Round 3
Aurther ran from the situation he was in towards the horse.
Lukas turned around and moved to help the explorer. In an excellent attack he destroyed the super zombie and damaged a skeleton.
Texan drove the car, even though the steering wheel was missing.
Remle picked up the radio and walked away from the skeletons.
The peaches advanced.
Round 4
Aurther oddly turned around and ran for the bridge stairs.
Lukas picked up the torch at the town well.
Texan and Remle got close to meeting each other.
The peach squad made it across the bridge and opened fire on the undead.
Round 5
In this round alot of zombies spawned
Aurther climbed to the top and tried not to be seen, but it was too late.
Lukas approached the dome.
Texan walked out of the ally as Remle passed by.
The peach squad sent their knife man after Aurther.
Round 6
Aurther, in haste climbed into the bridge tower. The floor boards broke under his weight. He got close to his secret mission to find the hidden crystal, which had been in the tower.
Lukas walked into the town as a zombie neared.
Texan climbed onto the horse. Remle tipped the water barrel over showing a pirate pistol, bow, quiver, and a golden telescope.
The peach squad was heavily hindered (this was very good for the players).
Round 7
Lukas burned the zombie and continued on towards the phone.
As Texan and Remle rode the horse they got swarmed by undead.
The peach squad was still fending off the undead.
Round 8
The giant crab arose from below the dock.
Lukas checked out the box behind him and found a katana and a knife.
Texan and Remle broke free from the undead.
The peach squad seemed like it might get a chance to do something.
The crab was hungry.
Round 9
Lukas droped the torch in the bamboo pit, causing an explosion. Then jumped on the car and hacked at some skeletons.
Remle and Texan arived as the bamboo exploded.
The peach squad's backup showed up.
The crab ate a zombie.
Round 10
The shopkeeper opened the weapon shop on this round.
Lukas kept fighting ontop the car.
Texan rode further into town and killed the shop keeper, completing the first part of his secret mission.
Remle got off the horse and jumped into the bar.
The crab continued its rampage as the peach shot at it.
The zombie slayers showed up.
Round 11
Lukas continued to fight.
Texan rode out of town.
Remle shot the zombie bar owner and ran to a spot where he hoped he wouldn't be seen.
The crab attacked the peach squad.
The zombie slayers managed to set the car on fire, even managing to get Dr. Lukas.
Round 12
The super zombie respawned
Lukas followed Texan
Remle took a look out of the bar to shoot a skeleton, who spotted him.
The peach squad killed the crab with a well placed shot.
The zombie slayer pyro set off the explosives in the weapon shop, causing the ruble to kill the ninja who was chasing Lukas.
Round 13
Lukas survied the attack from the super zombie as he followed Texan.
Texan rode into town and helped the zombie slayers, so they didn't attack him.
Remle got rid of the skeleton whom saw him, but stayed in the bar.
The zombie slayers went further into town.
The game was then over.
Thanks for reading.
Zombie Outbreak - FINISHED
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The Domino-US Reclining Living Room Group by Klaussner International at Find Your Furniture in the area. Product availability may vary. Contact us for the most current availability on this product.
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The Domino-US collection is a great option if you are looking for Casual furniture in the area.
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Posts on this site may contain an affiliate link. Please see full disclosure policy for more information.


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The Benefits of WeedsCreated: 6/10/2014 Updated: 8/9/2016
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Ok. Ok. There are a lot of Norway maple haters out there, and I think they are justified in their position. I agree with everything Seth said in this post, and I'd certainly see a sugar maple instead of a Norway. That said, there's an old one outside my house and everyone (including me) enjoys the shock of bright yellow when the leaves turn colors overnight in the autumn. Few people though notice the flowers of the maple. Lots of trees flower before they leaf out in the spring and maples are among these. The flowers are pretty small and the petals are about the same color as the bracts, resulting in a powdery yellow cloud appearing in a cloud around the twigs of the tree. If you're lucky enough to have squirrels in your neighborhood, you may notice them clipping off these flowers. They are doing this to access the sweet sap, maple syrup in the raw, and unintentionally they are pruning the tree, keeping it a nice, compact shape. They are also delivering little monochromatic bouquets of maple flowers to you. My kids have been decorating the dinner table with bowls of floating bouquets of maple flowers and arranging them in tiny vases in their doll house. Take a moment to give inconspicuous flowers like those of the maple a close look. You'll find a cheerful beauty.
Norway Maple Blooms
Speaking of cheerful weeds, violets are blooming in profusion these days. Sure they're weedy but they are not to aggressive and I think they are cute. Plus, their flowers make any dish more beautiful. Sometimes the flowers even have a delicate violet pastille flavor, but you can't guarantee this with the weedy ones.
Finally, this is the week to work on garlic mustard. It's a vilified weed in this country and rightfully so. It crowds out our native wildflowers both physically and chemically. (Within its native range, it is a valued wildflower itself and host of a butterfly). Wherever you see it, pull up the beast. This is the best time of year to do so because it has not begun to seed and the soil is easy to work. You may see patches of trillium, ginger or other wildflowers that are surrounded by garlic mustard. Help them out and carefully pull all the mustard nearby. Make sure to clean your boots and pats when you are done though, especially once the plants begin to set seed. It has been observed that garlic mustard is often more common in the gardens of nature lovers and their neighbors. Presumably we are tracking seeds around.
Lake Trout with garlic mustard pesto
The reason this is my favorite week for pulling garlic mustard though is because the plants have begun to bolt—they're sending their flower stalks up. Pick these stalks before many flowers have opened and steam them as you might asparagus, or mince them into a pesto. You can eat the leaves, too but they are often more bitter. No matter what, I like to add quite a bit of salt to counteract the bitterness and I often cook the shoots with an acid like lime juice or balsamic vinegar, depending on the cuisine. You can often add garlic mustard to Southeast Asian dishes without modifying the recipe. Burmese and Cambodian both regularly make use of bitter herbs; my daughters love adding garlic mustard to Vietnamese spring rolls. As with violets, since these are not cultivated m the flavor can vary from plant to plant so taste as you pick. By adding a bit of garlic mustard to your springtime diet you are helping native ecosystems, eating sustainably, and adding interesting variety to your diet.
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Wilco can morph
I haven't yet heard Wilco's new album, A Ghost is Born. Be that as it may, Mark Grabowski's review of it ["Making a case," May 6] left me, and hopefully most of his readers, pretty down.
Grabowski seems to have written off this latest effort by Wilco because it departs from the mostly recognizable pop spirit of the band's earlier work. While I guess someone ought to apologize to Grabowski for "I Am the Walrus" not sounding much like "Love Me Do," I'm afraid I can't be the one.
It could certainly turn out that A Ghost is Born is a stinker of a record. It could be that the attempt to bring this one together just plain stumped Wilco. But it occurs to me nonetheless that artists are people, people who listen to the heart's advice with an ultimately exclusive attention. Otherwise, they lead the same kind of a life that we do, a life prone to constant changes, surges, and failings of that same indomitable heart.
Perhaps it's just that artists are more dishonest than we are, still hollering into the face of our cynical, heat-swollen consumerism that you can try to change your life or your art and go unpunished for it. If that's the case, well, make me dishonest.
Jonathan G. Williams


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The Playoff Picture
Carlos Ramirez was 5 for 5 with two homers and two doubles, as the Orem Owlz won Friday 10-0 at Missoula.
After losing Game #1 Thursday at home to the Osprey, the Owlz got on the bus for the 550-mile ride for Missoula, facing the unlikely task of winning Games #2 and #3 on the Osprey's home turf to take the Pioneer League pennant.
But after last night's 10-0 rout, the Owlz have given themselves a fighting chance to capture the flag.
Stephen Locke pitched a complete game shutout, allowing only four hits while striking out five and walking one.
The Owlz hit six homers, a Pioneer League playoff record for one game. Eleven of their fifteen hits were extra base hits.
Catcher Carlos Ramirez was 5 for 5 with two homers, two doubles and a single.
Kevin Ramos, Justin Bass, Casey Haerther and Michael Wing also homered.
So it's winner take all tonight at Missoula.
Orangel Arenas starts for the Owlz. During the regular season, he was 4-3 with a 4.65 ERA in 69 2/3 innings. In his last three starts, he gave up 11 earned runs in 11 innings. His last start was on September 10. Missoula starts Charles Brewer, 7-2 with a 2.47 ERA in 54 2/3 innings. He was selected by the Angels in the 18th round of the June 2006 draft, but he didn't sign. The Brewers got him this year in the 12th round out of UCLA after his junior year.
Last year, Great Falls won on the Owlz' home field. Hopefully the Owlz will balance out the karma tonight.


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I said we'd be seeing Giganotosaurus again soon, and by golly, here he is.
That's one of the largest carnivorous dinosaurs of all time. I ran into this bad boy at the Maryland Science Center, within spitting distance of Federal Hill and the USS Constellation in Baltimore's Inner Harbor. I had some extra time after visiting Ft. McHenry, so I stopped by to indulge in a little dino-viewing.
Most of the dinos at the MSC are casts, including the Giganotosaurus, but they're beautiful mounts all the same. I especially like this dynamic, lunging T. rex.
Donald Gennaro's last view:
And here's Tarbosaurus, T. rex's cousin from Mongolia.
Two very early dinosaurs from South America, Eoraptor and Herrerasaurus.
Cryolophosaurus, a pompadour-sporting meat-eater from Antarctica. (Yep, dinosaurs in Antarctica.)
Finally, here's an Acrocanthosaurus in the flesh…
…trying to take down an Astrodon, Maryland's state dinosaur. This scene is based on a famous trackway from Texas excavated by R.T. Bird and recently reconstructed digitally.


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Sentence too harsh
Over the last 30 years, the length of our prison sentences has dramatically increased. Crimes that formerly resulted in a one-year sentence now carry a mandatory minimum sentence of 20 years or longer. Florida legislators report that the main forces causing the continuing pattern of passing new laws with ever longer sentences are the private prison industry and related participants in the criminal justice system who benefit from keeping more people locked up for longer periods.
A sad victim of this phenomenon is the hapless young local actor, Charles McKenzie III, whose effort to reduce the 30-year sentence imposed upon him by Judge Donna Berlin was reported in this newspaper Thursday. The sentencing guidelines for his crime ranged from 22 years to 40 years.
What was his crime? In the past, only a person who committed a most violent, vicious and ugly crime, such as first degree torture murder, would have been sentenced to 22 to 40 years. But Mc-Kenzie's only crime was that he seduced a 14-year-old girl when he was 22.
I do not intend to minimize the psychological injury caused to the girl by having sex at such a young age, but this crime cannot possibly be compared with a vicious violent crime resulting in death. Something in the range of one to five years would be more than adequate to deter other young men from similar behavior and to punish McKenzie for what he did.
James D. Keeney
Punishment fits crime
In "Actor asks shorter term for sex crime" (Thursday's Herald-Tribune), a man was sentenced to 30 years in jail for having sexual relations with a 14-year-old girl. He is seeking a reduced sentence, pleading that he didn't think it was that big of a deal. He states that he knew what he did was illegal. With that said, in my opinion he deserves the sentence that the judge has already given him. Luring a teenager out of her home to molest her is absolutely intolerable.
Not only is it wrong what he did, he is now trying to get out of it. This article states that Charles McKenzie III was labeled a sex offender in 2010. It is only 2013, three years later, and he is already trying to get out of jail. No way! He needs to stay there where he belongs.
I am a teenage girl who is constantly on the lookout for predators. I would feel extremely uncomfortable knowing he was back on the streets.
Elizabeth Coblentz
Losing sense of security
Columnist Tom Lyons needs to interview people who live in Tamaron on a full-time basis and call the neighborhood home ("In HOA newsletter, surprises for some," Thursday's Herald-Tribune).
Taking a family residential neighborhood and transforming it into a commercial motel district atmosphere deprives many of us of a sense of security and safety in knowing the people who live here have an investment in our quality of life. That has changed, with some homes being used like a motel and rented by the week or by the month, and buses pulling up with a load of tourists. It is sad that the new owners see these homes as quick cash and not leasing on a annual basis to provide a home for those who would settle into a beautiful residential neighborhood.
Dawn Holback
SHS student feels safe
I'm a senior at Sarasota High School. I came across the "Keeping students from harm" article in Wednesday's Herald-Tribune and I found it pretty interesting. I personally have always felt safe at school. At Sarasota High there are at least six administrators or security guards riding around making sure everyone's staying out of trouble. It's impossible to avoid them -- trust me, I've tried.
Even though SHS is an open campus, it is guarded very well, with cameras at every angle. That's why, in my opinion, more money should be spent on mental health programs and making students aware of mental illnesses so they can read the signs clearly. I completely agree with School Board member Frank Kovach, who said, "To me, you have to detect the mental illness, because if someone wants to do damage they're going to do damage."
Also, I think a seminar telling students how to recognize threats on Facebook or other social media is a good idea. And if they see any suspicious activity, that there is a place at school to anonymously go and report any findings. Keeping our schools safe isn't something the School Board can do alone. It is an effort that should involve students, parents and the entire community.
Katlin Thompson
Celebrating choice
On Jan. 22, 1973, the U.S. Supreme Court's landmark decision in Roe v. Wade affirmed every woman's right to make her own decision about abortion, to consider her own needs, beliefs and religious traditions. To commemorate this reproductive rights victory, the National Council of Jewish Women will begin celebrating Roe's 40th anniversary in January and continue until the end of the year. At the council's Washington Institute in March, we'll celebrate with our opening dinner and with other programs throughout the conference.
NCJW's Sarasota-Manatee Section will continue to work in coalition with our partners, including Planned Parenthood, Americans United, local temples, synagogues and churches, as we continue advocating for every woman's right to reproductive choices during this anniversary year. This is particularly important in our home state of Florida, where defeat of Proposition 6 clearly showed that Florida residents support personal choice concerning women's health issues.
Karen G. Pariser
Vice President of Advocacy
National Council
of Jewish Women,
Sarasota-Manatee Section
Sunday's letters
Sentence too harsh


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Q My 75-year-old friend has been diagnosed with kidney failure. Dialysis shows that her kidneys are working 15 per cent below normal efficiency. We are very perplexed why this should have happened as she has led a healthy life, and has always had a good diet. Is very much known about kidney failure? Why should it happen and can it be cured, hopefully by natural, non-drug, therapies? - GA, Kent
A The kidneys remove waste from the blood via the urine; they regulate the levels of water and different minerals needed by the body, and they also produce hormones that control other bodily functions such as blood pressure.
Kidney failure comes in two forms. Acute kidney failure happens when the kidneys fail suddenly. They can return to normal functioning after a while, although dialysis may be needed until they begin to work again. Your friend, however, has chronic kidney failure, or chronic renal insufficiency, a condition that is irreversible. Indeed, if the efficiency of her kidneys is as poor as you state, she has endstage renal disease (ESRD) and will most definitely require dialysis to stay alive. Eventually, she may even need a kidney transplant.
Sometimes, it is not possible to get to the bottom of why a kidney is failing. Chronic cases can be brought on by diabetes, high blood pressure, kidney stones or a painless inflammation of the kidneys called glomerulonephritis. Case reports have also attributed incidents of acute kidney failure to the use of painkilling drugs such as aspirin, ibuprofen and naproxen. However, these patients often had other risk factors, such as systemic lupus erythematosus, advanced age or a chronic kidney condition, or had been bingeing on alcohol (PROOF!, vol 3 no 2, Q&A).
Acute cases can also be brought on by shock, usually as a result of a sudden blood loss or a heart attack, or by the sudden blocking of the ureters, bladder or urethra, often by kidney stones. Tell-tale symptoms can include poor urination, loss of appetite, abnormal sleep patterns or drowsiness.
Chronic cases can be brought on by recurrent inflammation (high blood pressure, kidney stones or glomerulonephritis, as mentioned above). Inflammation can also be caused by cadmium, although the most common cause is frequent use of aspirin and other similar painkillers.
The kidneys can repair themselves - but only in acute cases - and this also depends on the age and general health of the patient. Kidney failure is treated by a combination of methods, including diet, medication and possibly dialysis, according to the type of disease and severity.
Now that your friend is on dialysis, she should certainly continue with her good diet. If she's not already doing so, this should include essential fatty acids, which may help to protect the kidneys. In cases of kidney disease, a dose of 12 g daily has been shown to retard the rate of kidney function decline (N Engl J Med, 1994; 331: 1194-9). Although not yet proved conclusively, lowering protein intake may also be of some benefit (N Engl J Med, 1994; 330: 877-84).
Salt increases thirst, making it more difficult for patients to restrict their fluid intake. Sodium is, of course, an essential nutrient, but doctors are still a long way from finding the healthy middle ground between consuming too much and too little (Am J Hypertens, 2001; 14: 653-9). If she doesn't want to give up salt, she could try replacing it with a low-sodium alternative (WDDTY, vol 5 no 7, News).
Potassium is a mineral that, among other things, works in conjunction with sodium to keep water levels in the body consistent; the kidneys would normally remove any excess. Too much potassium is bad for the heart but, as you can't taste potassium like you can salt, its intake is more difficult to control and it isn't listed on food labels. High potassium levels are found in nuts, avocados, potatoes, oranges, peaches, apricots and anything dried, such as fruits, beans and lentils. Low potassium foods include grapes, tangerines, tinned pears and plums, asparagus, green beans, corn, cauliflower, cucumbers, water chestnuts and squash. Juices such as apple, cranberry, lemonade, grape and fruit-flavoured drinks are also fine.
Protein also plays an important role in the diet of any kidney patient. Low levels can lead to fluid retention and a reduced capacity of the body to fight off infection.
Finally, your friend must keep her blood pressure in check with regular exercise; deal promptly with any urinary tract infections as, left untreated, these can spread to the kidney; limit her exposure to toxic metals; and avoid unnecessary use of over-the-counter medicines, especially aspirin and other painkillers.
She may also wish to support her healthful regimen with homoeopathy.


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Long-Term Acute Care Hospitals are accredited by the Joint Commission on Accreditation of Healthcare Organizations, certified by Medicare and licensed as an acute long-term care hospital providing specialized medical care to acutely ill patients requiring extended recovery time after the acute care hospital stay.
PAM Specialty Hospital of Victoria South is located inside of DeTar Medical Center.
Patients are stable enough to transfer but medically complex and often admitted directly out of ICU. Patients are medically and physically compromised with multi-system complications that require acute hospitalization. The length of stay is determined by each individual patient's needs based on their diagnosis and treatment program. The average length of stay is over 25 days. We participate in a variety of insurance plans with out-of-network plans negotiated on a case-by-case basis. LTACH's are licensed acute care hospitals and utilize acute hospital days. We bridge the gap of services for those who need a continued high level of acute care for a longer length of time. Due to multiple medical issues, our patients require daily physician observation and care, as well as the intense services of an interdisciplinary team.
To learn more about our hospital and services click here.
Main Phone: 361-485-7300
Referral Phone: 361-580-5116
Referral Fax: 361-580-1213
Our Address:
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3rd Floor of Detar Hospital
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|Biosequences .. Software .. Molbio soft .. Network News .. FTP
brett at BORCIM.WUSTL.EDU (brett) wrote: >Hello, I'm trying to ppt. my protein using cold acetone. It was in a 50uM >sodium phosphate buffer. I added 8 vol. acetone, and now have a large, >chunky ppt. I believe the large chunks are phosphate, as buffer alone gave >the >same appearance. Parallel ppt's of the same protein in a citrate buffer >gave a finer, milky ppt. I now want to dry down the pellets and resuspend >them for SDS-PAGE analysis, but am worried about the salt. Anyone have any >suggestions for what to do? I thought I might resuspend the chunky pellets, >dialyze into another buffer, and reppt. Thanks in advance, > > > >Brett Lindenbach > >Program in Immunology >Washington University - St Louis >brett at borcim.wustl.edu > >"I own my own pet virus. I get to pet and name her." - Cobain > I have successfully precipitated protein out of a 20mM potassium phosphate buffer for SDS-PAGE. I add TCA to 10% final concentration and let it sit for 10-20 minutes collect by cetrifugation and wash the pellet with acetone. This has given some nice gels from pretty dilute samples. Happy Hunting Ron Tate OSU BMB


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Photo: NASA's Marshall Space Flight centre | Flickr
A study published this week suggests that there may be "tens of billions" of planets in the Milky Way galaxy that fall within what scientists call "the Goldilocks zone," where the conditions for spawning life are thought to exist.Working with a relatively new technology called the HARPS spectrograph, located at the La Silla Observatory in Chile, scientists said that a survey of red dwarf stars in the Milky Way found that approximately 40 per cent had planets orbiting within the Goldilocks zone. They also estimate there are about 160 billion red dwarf stars in our galaxy.
So far, just nine planets within this zone have actually been detected, but extrapolations from the survey indicate that planets falling under this criteria may be exceedingly common throughout the galaxy. And about 100 are within earth's cosmic neighbourhood, they said.
"Now that we know that there are many super-Earths around nearby red dwarfs, we need to identify more of them using both HARPS and future instruments," Xavier Delfosse, a researcher with the Observatoire des Sciences de l'Univers de Grenoble in France, told Space.com editor Clara Moskowitz. "Some of these planets are expected to pass in front of their parent star as they orbit — this will open up the exciting possibility of studying the planet's atmosphere and searching for signs of life."
This video was published to YouTube by NASAtelevision on Sept. 29, 2010.
This post originally appeared at The Raw Story.
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As the title suggests, I am looking at installing a shade sail to provide some shade for a newly built patio.
The house is brick and tile and based on the shape of the house, it would make sense to have the sail partially attached to the house.
I've done some reading and it would seem that due to the tremendous lateral force applied to the connection points, you have to think really carefully about how you attach your sail.
I was wondering if anyone had any pointers, etc...
The house has brick veneer and I have a feeling that simply attaching a sail to these bricks (even trying to attach to as many as possible using one of these plates) might not cut it...
Alternatively, I might look at getting a company to come and do the job rather than risking to eff it up myself so I would welcome any review/suggestion on these type of companies around Auckland (North Shore)
Thanks heaps,


text:
I got another thrill when her adoring husband called and asked if I could stay for dinner because he is cooking up a feast to celebrate his beloved. I had to let him in on the little detail that I had already been invited to spend the night...... Surprise! When he told me what the menu was, I started salivating instantly. Needless to say, I can't wait for tonight.
So, let me take a moment to let you know, in case you're new around here, just how amazing my best friend is. I know you don't have ALL day to read this post, so this is the condensed version. Mia is one-of-a-kind. I think any one who knows her would have to agree. Even though she is beautiful and oozing with talent, she is one of the most humble and down to earth people I know. She is beyond hilarious, and has said some of the funniest things I've ever heard in my life. In fact, whenever my mother-in-law is visiting and Mia stops by, she races to put her hearing aids in, so as to not miss a single word she says! I have laughed myself right into the bathroom on thousands of occasions. And been a little too late a few times, too.
She serves her friends, neighbors, church, and perfect strangers with a willing heart. She is always taking a meal, hosting a party, setting up for a wedding, designing announcements, sewing a window treatment, or whipping treats up for the 20 teenagers who have unexpectedly dropped by. And she always says the same thing, "It was so much fun!"
Mia has been by my side over the past twelve years, through the good, the bad, and the ugly, and there have been plenty of all three! We have laughed until we've lost our voices, cried boatloads of tears together, traveled all over the countryside, been in business(es) together, and drug our families through all sorts of crazy shenanigans. We have had more adventures (and misadventures) than a couple of girls should ever be lucky enough to experience together. My life has been richly blessed to have found a friendship as effortless and lasting as this one. I love her with all my heart. Happy Birthday, to my dear Best Friend!
And.....there was another birthday girl this week. My very own 18 year old daughter! I just can't even begin to imagine where the years have gone. We have been through some rough and uncertain times together, and she has always been right there, holding my hand and assuring me that things would work out. She is strong and brave, courageous and kind. Her character is unshakeable and I am so proud she's mine. She has grown into a beautiful young woman, and I can see a very bright future spanning out before her. She will do amazing things in her life because she knows who she is. I love this girl. I am so lucky to be her Mom.
All the love circulating around this week got me motivated to complete a quick project for my front door. I would have hung it on the exterior of the door, but because of the numbers I installed, it just wasn't going to work. See the door transformation {here}.
So I decided to do something a little bit different and love up the inside of the front door. I bought the massive, paper mache letters from JoAnns (they were $10 each) and spray painted them gold one frigid night at midnight. (did you know it's been in the low 20's at night around here?) I think the nozzle might have slightly malfunctioned because of the cold weather since I've never had this happen before!
But no matter, I got the job done! The next day, I taped off some stripes with masking tape and painted them light pink.
We added a pattern to the top half of the windows with contact paper:
And cut a door down to add wood panels to the bottom half, both explained {here}.


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Summary: Lysophospholipase catalytic domain
Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.
This is the Wikipedia entry entitled "Lysophospholipase". More...
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Lysophospholipase Edit Wikipedia article
|EC number
|CAS number
|IntEnz view
|BRENDA entry
|NiceZyme view
|KEGG entry
|metabolic pathway
|PDB structures
|RCSB PDB PDBe PDBsum
|Gene Ontology
|AmiGO / QuickGO
|Lysophospholipase, catalytic region
In enzymology, a lysophospholipase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reaction
- 2-lysophosphatidylcholine + H2O glycerophosphocholine + a carboxylate
Thus, the two substrates of this enzyme are 2-lysophosphatidylcholine and H2O, whereas its two products are glycerophosphocholine and carboxylate.
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. This family consists of lysophospholipase / phospholipase B EC 188.8.131.52 and cytosolic phospholipase A2 which also has a C2 domain InterPro: IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophospholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells.[1] Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids,[2] the aligned region corresponds the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in.[2]
The systematic name of this enzyme class is 2-lysophosphatidylcholine acylhydrolase. Other names in common use include lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, and NTE-lysophospholipase. This enzyme participates in glycerophospholipid metabolism.
Human genes encoding proteins that contain this domain include:
- ^ Nalefski EA, Sultzman LA, Martin DM, Kriz RW, Towler PS, Knopf JL, Clark JD (1994). "Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain". J. Biol. Chem. 269 (27): 18239–18249. PMID 8027085.
- ^ a b Lee KS, Patton JL, Fido M, Hines LK, Kohlwein SD, Paltauf F, Henry SA, Levin DE (1994). "The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity". J. Biol. Chem. 269 (31): 19725–19730. PMID 8051052.
Further reading
- Abe M, Ohno K & Sato R (1974). "Possible identity of lysolecithin acyl-hydrolase with lysolecithin-lysolecithin acyl-transferase in rat-lung soluble fraction". Biochim. Biophys. Acta. 369: 361–370. doi:10.1016/0005-2760(74)90150-7.
- Contardi A & Ercoli A (1933). "The enzymic cleavage of lecithin and lysolecithin". Biochem. Z. 261: 275–302.
- Dawson RMC (1958). "Studies on the hydrolysis of lecithin by Penicillium notatum phospholipase B preparation". Biochem. J. 70: 559–570.
- Fairbairn D (1948). "The preparation and properties of a lysophospholipase from Penicillium notatum". J. Biol. Chem. 173: 705–714.
- SHAPIRO B (1953). "Purification and properties of a lysolecithinase from pancreas". Biochem. J. 53 (4): 663–6. PMC 1198209. PMID 13032127.
- van den Bosch H, Aarsman AJ, de Jong JG, van Deenem LL (1973). "Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas". Biochim. Biophys. Acta. 296 (1): 94–104. doi:10.1016/0005-2760(73)90048-9. PMID 4693514.
- van den Bosch H, Vianen GM, van Heusden GP (1981). "Lysophospholipase--transacylase from rat lung". Methods Enzymol. 71 Pt. C: 513–21. doi:10.1016/0076-6879(81)71061-9. PMID 7278668.
- van Tienhoven M, Atkins J, Li Y, Glynn P (2002). "Human neuropathy target esterase catalyzes hydrolysis of membrane lipids". J. Biol. Chem. 277 (23): 20942–8. doi:10.1074/jbc.M200330200. PMID 11927584.
- Quistad GB, Barlow C, Winrow CJ, Sparks SE, Casida JE (2003). "Evidence that mouse brain neuropathy target esterase is a lysophospholipase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7983–7. doi:10.1073/pnas.1232473100. PMC 164699. PMID 12805562.
- Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man". Biochem. J. 332 (Pt 1): 1–4. PMC 1219444. PMID 9576844.
- Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003). "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity". Nat. Genet. 33 (4): 477–85. doi:10.1038/ng1131. PMID 12640454.
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Lysophospholipase catalytic domain Provide feedback
This family consists of Lysophospholipase / phospholipase B EC:18.104.22.168 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain PF00168. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all phospholipids extractable form yeast cells [1]. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [2] the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in [2].
Literature references
Nalefski EA, Sultzman LA, Martin DM, Kriz RW, Towler PS, Knopf JL, Clark JD; , J Biol Chem 1994;269:18239-18249.: Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain. PUBMED:8027085 EPMC:8027085
Lee KS, Patton JL, Fido M, Hines LK, Kohlwein SD, Paltauf F, Henry SA, Levin DE; , J Biol Chem 1994;269:19725-19730.: The Saccharomyces cerevisiae PLB1 gene encodes a protein required for lysophospholipase and phospholipase B activity. PUBMED:8051052 EPMC:8051052
Internal database links
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002642
This family consists of lysophospholipase / phospholipase B EC and cytosolic phospholipase A2 which also has a C2 domain INTERPRO. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells [PUBMED:8027085]. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [PUBMED:8051052], the aligned region corresponds the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in [PUBMED:8051052].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function
|phospholipase activity (GO:0004620)
|Biological process
|phospholipid catabolic process (GO:0009395)
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan Patatin (CL0323), which has the following description:
This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.
The clan contains the following 4 members:Acyl_transf_1 Patatin PLA2_B SAT
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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|Representative proteomes
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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|Representative proteomes
|Raw Stockholm
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
If you find these logos useful in your own work, please consider citing the following article:
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
|Seed source:
|Pfam-B_2127 (release 4.1)
|Previous IDs:
|Sequence Ontology:
|Bashton M , Bateman A
|Number in seed:
|Number in full:
|Average length of the domain:
|350.90 aa
|Average identity of full alignment:
|25 %
|Average coverage of the sequence by the domain:
|56.45 %
HMM information
|HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
|Model details:
|Model length:
|Family (HMM) version:
|download the raw HMM for this family
Species distribution
Sunburst controlsHide
Weight segments by...
Change the size of the sunburst
Colour assignments
|Other sequences
|Unclassified sequence
Align selected sequences to HMM
Generate a FASTA-format file
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Currently selected:
- 0 sequences
- 0 species
This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
This chart is a modified "sunburst" visualisation of the species tree for this family. It shows each node in the tree as a separate arc, arranged radially with the superkingdoms at the centre and the species arrayed around the outermost ring.
How the sunburst is generated
The tree is built by considering the taxonomic lineage of each sequence that has a match to this family. For each node in the resulting tree, we draw an arc in the sunburst. The radius of the arc, its distance from the root node at the centre of the sunburst, shows the taxonomic level ("superkingdom", "kingdom", etc). The length of the arc represents either the number of sequences represented at a given level, or the number of species that are found beneath the node in the tree. The weighting scheme can be changed using the sunburst controls.
In order to reduce the complexity of the representation, we reduce the number of taxonomic levels that we show. We consider only the following eight major taxonomic levels:
- superkingdom
- kingdom
- phylum
- class
- order
- family
- genus
- species
Colouring and labels
Segments of the tree are coloured approximately according to their superkingdom. For example, archeal branches are coloured with shades of orange, eukaryotes in shades of purple, etc. The colour assignments are shown under the sunburst controls. Where space allows, the name of the taxonomic level will be written on the arc itself.
As you move your mouse across the sunburst, the current node will be highlighted. In the top section of the controls panel we show a summary of the lineage of the currently highlighed node. If you pause over an arc, a tooltip will be shown, giving the name of the taxonomic level in the title and a summary of the number of sequences and species below that node in the tree.
Anomalies in the taxonomy tree
There are some situations that the sunburst tree cannot easily handle and for which we have work-arounds in place.
Missing taxonomic levels
Some species in the taxonomic tree may not have one or more of the main eight levels that we display. For example, Bos taurus is not assigned an order in the NCBI taxonomic tree. In such cases we mark the omitted level with, for example, "No order", in both the tooltip and the lineage summary.
Unmapped species names
The tree is built by looking at each sequence in the full alignment for the family. We take the name of the species given by UniProt and try to map that to the full taxonomic tree from NCBI. In some cases, the name chosen by UniProt does not map to any node in the NCBI tree, perhaps because the chosen name is listed as a synonym or a misspelling in the NCBI taxonomy.
So that these nodes are not simply omitted from the sunburst tree, we group them together in a separate branch (or segment of the sunburst tree). Since we cannot determine the lineage for these unmapped species, we show all levels between the superkingdom and the species as "uncategorised".
Since we reduce the species tree to only the eight main taxonomic levels, sequences that are mapped to the sub-species level in the tree would not normally be shown. Rather than leave out these species, we map them instead to their parent species. So, for example, for sequences belonging to one of the Vibrio cholerae sub-species in the NCBI taxonomy, we show them instead as belonging to the species Vibrio cholerae.
Too many species/sequences
For large species trees, you may see blank regions in the outer layers of the sunburst. These occur when there are large numbers of arcs to be drawn in a small space. If an arc is less than approximately one pixel wide, it will not be drawn and the space will be left blank. You may still be able to get some information about the species in that region by moving your mouse across the area, but since each arc will be very small, it will be difficult to accurately locate a particular species.
Tree controlsHide
Download tree
- Save a text representation
Selected sequences
- (Uncheck all)
- graphically
- as an alignment
- sequence accessions
- sequences in FASTA format
The tree shows the occurrence of this domain across different species. More...
Species trees
We show the species tree in one of two ways. For smaller trees we try to show an interactive representation, which allows you to select specific nodes in the tree and view them as an alignment or as a set of Pfam domain graphics.
Unfortunately we have found that there are problems viewing the interactive tree when the it becomes larger than a certain limit. Furthermore, we have found that Internet Explorer can become unresponsive when viewing some trees, regardless of their size. We therefore show a text representation of the species tree when the size is above a certain limit or if you are using Internet Explorer to view the site.
If you are using IE you can still load the interactive tree by clicking the "Generate interactive tree" button, but please be aware of the potential problems that the interactive species tree can cause.
Interactive tree
For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
We also count the number of unique sequences on which each domain is found, which is shown in green. Note that a domain may appear multiple times on the same sequence, leading to the difference between these two numbers.
Finally, we group sequences from the same organism according to the NCBI code that is assigned by UniProt, allowing us to count the number of distinct sequences on which the domain is found. This value is shown in the pink boxes.
We use the NCBI species tree to group organisms according to their taxonomy and this forms the structure of the displayed tree. Note that in some cases the trees are too large (have too many nodes) to allow us to build an interactive tree, but in most cases you can still view the tree in a plain text, non-interactive representation. Those species which are represented in the seed alignment for this domain are highlighted.
You can use the tree controls to manipulate how the interactive tree is displayed:
- show/hide the summary boxes
- highlight species that are represented in the seed alignment
- expand/collapse the tree or expand it to a given depth
- select a sub-tree or a set of species within the tree and view them graphically or as an alignment
- save a plain text representation of the tree
Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.
There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PLA2_B domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
Loading structure mapping...


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- My Feedreader is consistently at 1,000+ unread posts.
- My Mage category is consistently at 150+ unread posts
- My Shaman category is consistently at 90+ unread posts
Dont get me started on the others…
Anyway, this means I do stupid things like hassle harried history students about things that I could probably work out myself, while my feedreader laughs at me because 2 posts away are tons of posts about Fire Mages in General and Fire PvP Specifically.
So apologies up front to Rip if I have dragged him away from his studies. If you have started, don't stop. I haven't found a source of Fire Mages enchants and gemming wisdom yet…
Meanwhile here are some links...
Great Balls of Fire
The Grumpy Mage
I know there were more.. but of course as I write this I can't find them…
Gnomer and Out!
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.


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All RIT employees need to be aware of the business risks in their area of responsibility. To help mitigate those business risks, each division, college, and department is responsible for establishing and maintaining effective business practices and internal controls. To assist the University in achieving its objectives, it is vital that a strong internal control environment exists in all aspects of the RIT Community.
One result of weak or broken internal controls is Fraud. Occupational fraud can be found in any workplace. Whether an organization is a non-profit entity such as a university, or a large for-profit corporation, fraud has occurred and continues to occur. This combined topic class will provide you with the knowledge to understand how good internal controls can help prevent fraud from occurring in your area of responsibility.
During this class, the importance of, components of, and the responsibility for establishing and maintaining effective internal controls will be discussed. Various examples of what can happen when controls are non-existent or broken (i.e., fraud) will be shared throughout the class.
By attending this class you will learn:
- What are internal controls?
- Why should we care about internal controls?
- What aspects comprise a good internal control structure?
- Who is responsible for internal controls?
- What are some examples of internal controls?
- Why you should be concerned about fraud.
- Who typically commits fraud, and why.
- Common fraud myths.
- Methods typically used by individuals committing fraud.
- How you can reduce the risk of fraud in your area of responsibility.
- How to report suspected fraudulent activity.
- About real fraud cases investigated by the instructor.
- What to look for to detect potential fraud.
Who should attend?
Any RIT employee with an interest in learning about internal controls and how to help protect their area of responsibility from potential fraudulent activity.
* Completion of this course is required to obtain your Accounting Series Certificate of Completion. All officers and managers in the university are required to attend.
Participant Comments
"This session brought to light ethics in the work environment on an everyday basis."
"Great class, very informative, a worthwhile use of my time."
"Very well done - the discussion of actual fraud documentation was interesting and frightening. I would like to see this class required for everyone."
Please note this session will be conducted virtually via Zoom.
Internal Controls and Fraud in the Workplace is facilitated by members of the Institute Audit, Compliance & Advisement (IACA) Department.
Wendy Roy is a Manager for RIT's Institute Audit, Compliance and Advisement and has enjoyed over 17 years of higher education internal auditing experience between her tenure here at RIT and at the University of Rochester. Wendy is a CPA (Certified Public Accountant) who began her auditing career in 1998 working for the largest regional CPA firm in Rochester. Prior to that, she spent 10 years working in the finance department of a large Rochester-based manufacturing company.
Patrick Didas is the Assistant Vice President of Institute Audit, Compliance and Advisement. He is a CPA, a CFE (Certified Fraud Examiner), and a CCA (Certified Construction Auditor) with over 23 years of higher education internal audit experience between RIT and the University of Rochester. He is a 1990 graduate of RIT's Saunders College of Business and has investigated financial fraud cases that have resulted in criminal prosecution and tens of thousands of dollars in restitution to his employers.


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Jenise wrote:Kinda like the others. For dipping and other condiment uses, I buy Tuscan EVOOs from Rare Wine. For cooking, I buy a Tuscan from Costco; I also use their extra light.
Whoever mentioned Trader Joe's, might be the Santini if Joe's still stocks that. Best for the price I've found anywhere.
Factoid: according to something I just received in the mail, a single olive tree only produces one liter of EVOO.
Chef Carey: we on FLDG have been using the term 'EVOO' since long before Rachel had a show. It's safe. Oh, and unfair pounce on Bernard. He was parroting Robin, and I enjoy the fact that he's proud to use the best quality ingredients he can buy.
The expression has been forever co-opted by the omnipresent Ray food machine. She's been drumming it into millions of soggy brains since 2001. It's lost. Happened in the past. Words like "communist," and "capitalist," for instance.
It did not seem to me there was any "parroting" going on. Seemed more like scoffing and suggesting Robin's palate was quotidian and less refined than his. Or, have I lost my ability to read with comprehension? Damn that speed reading teacher!
Factoid: Chef Carey is contentious and confrontational when he sniffs snobbery. Thus it ever was and thus it will be.
Oh, and I edited that post before I sent it, I thought I said a couple of unfair things in my first shot at it.
Maybe you should lock me out of the forum for "unfairness," since I'm sure I'm the first and only offender in that regard.


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Shanwei Weng-Black Cant System Fashion Store
At Design Interviews
Interview with SHANWEI WENG : Frank Scott: What is the main principle, idea and inspiration behind your design?. SHANWEI WENG : Space can be written. .Frank Scott: What has been your main focus in designing this work? Especially what did you want to achieve?. SHANWEI WENG : To explore the relationship between writing and spaceSpace solutions, and materialsAnd the overall tone of the control. .Frank Scott: What are your future plans for this award winning design?. SHANWEI WENG : Continue design. .Frank Scott: How long did it take you to design this particular concept?. SHANWEI WENG : Four months. .Frank Scott: Why did you design this particular concept? Was this design commissioned or did you decide to pursuit an inspiration?. SHANWEI WENG : A direct feeling; Customer demand for function, we are creative according to the function. .Frank Scott: Is your design being produced or used by another company, or do you plan to sell or lease the production rights or do you intent to produce your work yourself?. SHANWEI WENG : We are responsible for the design, by the cooperation of the construction side (third party) execution. .Frank Scott: What made you design this particular type of work?. SHANWEI WENG : Daily thinking, the feeling of the project itself; the status of the project itself, the state of the customer, the status of the space. .Frank Scott: Where there any other designs and/or designers that helped the influence the design of your work?. SHANWEI WENG : HEIKE products are black, we put the black as the main tone of space, melancholy and the future. .Frank Scott: Who is the target customer for his design?. SHANWEI WENG : Designers, photographers, media practitioners, art teachers, fashion lovers, text workers, etc. .Frank Scott: What sets this design apart from other similar or resembling concepts?. SHANWEI WENG : Black slope body piece of large cylinder overhead, accounting for a total area of about 50%, use of marble Space can be written, special materials, manual industrial sense, space unique solution. .Frank Scott: How did you come up with the name for this design? What does it mean?. SHANWEI WENG : A chance encounter, the concept of meaning: black, inclined plane, system, become the space visual tone. .Frank Scott: Which design tools did you use when you were working on this project?. SHANWEI WENG : SktchUP, Illustrator, CAD; Also, hand drawn, proofing, on-site modification, etc. .Frank Scott: What is the most unique aspect of your design?. SHANWEI WENG : Discussion on writing and space design, concepts and materials. .Frank Scott: Who did you collaborate with for this design? Did you work with people with technical / specialized skills?. SHANWEI WENG : We work together with the construction side to complete the project. .Frank Scott: What is the role of technology in this particular design?. SHANWEI WENG : New materials: the use of marble powder;The low technology treatment of metal, hand rough metal surface,The manual sense of the future. .Frank Scott: Is your design influenced by data or analytical research in any way? What kind of research did you conduct for making this design?. SHANWEI WENG : Our design is not affected by the data. .Frank Scott: What are some of the challenges you faced during the design/realization of your concept?. SHANWEI WENG : But we are trying to main material, proofing 10 several times, the metal part is also an intuitive judgment, it is our own to polish the small area of the metal, and then let the workers to determine the next step. .Frank Scott: How did you decide to submit your design to an international design competition?. SHANWEI WENG : An attempt. .Frank Scott: What did you learn or how did you improve yourself during the designing of this work?. SHANWEI WENG : Each content. .Frank Scott: Any other things you would like to cover that have not been covered in these questions?. SHANWEI WENG : No, thanks! .
Shanwei Weng-Black Cant System Fashion Store Images:
End of the article, click here to go back to previous page, or alternatively go back to Design Honor Magazine homepage.


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Reviewed By Walter W (Punta Gorda, FL) Reviewed for a 2008 Ford Mustang —12/27/2009 7:48 AM
Works much better than the 30 year old Intermatic it replaces. On/Off switch is welcome addition, so is pressure gage. Also quieter than the old one. Nice long power cord with fuse. Still a bit slow and I only use it to top off the tires on race day. Great small prtable device for the money.


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As the new fall TV season approaches, we'll be breaking down the biggest offerings from each network. Here's a look at highlights from ABC's fall 2011 lineup.
The ABC Fall TV Line-Up
The show that will make fairy tales the new superheroes
"Once Upon a Time"
When a small boy shows up out of the blue claiming to be the child she put up for adoption years earlier, a bail bonds collector named Emma Swan (Jennifer Morrison) is led to a small town populated by fairy tale characters like Jiminy Cricket and Rumplestiltskin - only they don't know they're really Jiminy Cricket and Rumplestiltskin, thanks to an evil queen's curse. In a parallel "fantasy" world, Snow White (Ginnifer Goodwin) and Prince Charming (Josh Dallas) struggle to free their kind from the spell, with Emma as the key. (Premieres Sunday, October 23)
U.S. & World
Living proof that TV isn't immune to the remake bug
"Charlie's Angels"
Charlie Townsend's butt-kicking crime stoppers have survived McG's big screen spoofing and have been reborn with a little more grit to go with the glamour. The new action-junkie trio are "Friday Night Lights" alum Minka Kelly, "General Hospital's" Annie Ilonzeh, and "Transformers" star Rachel Taylor. Following in the footsteps of David Doyle, Bill Murray, and Bernie Mac is Ramon Rodriquez as a younger, more shirtless Bosley. (Premieres Thursday, September 22)
The swinging 60s craze takes flight
"Pan Am"
Christina Ricci heads up this nostalgia-tinged ode to the "Jet Age." Set in 1963, "Pan Am" takes "Mad Men's" period chic and and sexual entanglements and throws in a heaping dose of Cold War espionage in these maybe-not-always-so-friendly skies. Series creators Jack Orman and Thomas Schlamme boast "ER," "Men of a Certain Age," "The West Wing," and "Parenthood" on their respective resumes, so anticipation is high. (Premieres Sunday, September 25)
A dish best served good-looking and wealthy
A young woman (Emily Van Camp) arrives in the Hamptons and instantly begins working her way into the lives of the rich and leisurely. However, she's harboring a dark secret, and isn't looking for a party as much as she's out for…well, you can probably guess. A gorgeous woman seeking vengeance on the overprivileged? Sure sounds like a meaty premise. The presence of veteran actress Madeleine Stowe ups the intrigue. (Premieres Wednesday, September 21)
The show that puts Tim Allen back in his comfort zone
"Last Man Standing"
"Toy Story" aside, movies have not been kind to Tim Allen. However, two things have been very, very kind to Allen: Unabashed manly boorishness and the sitcom format. Luckily, "Last Man Standing" has Allen playing a guy's guy who, this time around, has to contend with a house full of women. It's like a Bizarro "Home Improvement." (Premieres Tuesday, October 11)
The made-for-TV "Juno"
A single dad (Jeremy Sisto) who has been doing a decent job of raising his daughter (Emma Stone-alike Jane Levy) in New York City finally hits the wall when faced with the teen years. Scared and out of his depth, he moves them both to the suburbs amid soccer moms and manicured lawns. A lot of eye-rolling at all the utter uncoolness ensues. Comedy vets Cheryl Hines ("Curb Your Enthusiasm"), Alan Tudyk ("Dodgeball"), and Rex Lee ("Entourage") populate the 'burbs. (Premieres Wednesday, September 28)
Where women are women, and men are toddlers
"Man Up"
Three perpetual man-children (Mather Zickel, Christopher Moynihan, and Dan Fogler) struggle with the concept of "being a man" while navigating a world of video games and manscaping. Amanda Detmer and Teri Polo ("Meet the Parents") play the out-of-their-league women who tolerate their toddler-like behavior. (Premieres Tuesday, October 18)
The mid-season replacement we're looking out for
Now here's a concept we can get behind: A TV version of the Liam Neeson thriller "Taken" starring Ashley Judd and "Game of Thrones" star Sean Bean. "Missing" stars Judd as a former CIA agent who learns that her son has gone missing while studying abroad. The boy's disappearance may have something to do with his father (played by Bean) who was murdered (?) years earlier. Veteran actor Cliff Curtis is on hand just in case you had any lingering doubts about watching.
The complete fall line-up, with new shows in bold:
8:00pm - Dancing with the Stars
10:00pm – Castle
8:00pm - Last Man Standing
8:30pm – Man Up
9:00pm – Dancing with the Stars [Results]
10:00pm – Body of Proof
8:00pm - The Middle
8:30pm - Suburgatory
9:00pm - Modern Family
9:30pm - Happy Endings
10:00pm - Revenge
8:00pm - Charlie's Angels
9:00pm - Grey's Anatomy
10:00pm - Private Practice
8:00pm - Extreme Makeover Home Edition
9:00pm - Shark Tank
10:00pm - 20/20
Saturday Night College Football
8:00pm - Once Upon a Time
9:00pm - Desperate Housewives
10:00pm - Pan Am
PopcornBiz will be posting previews of all four major networks this week. Check out our Fall TV Preview: NBC and stay tuned for CBS and Fox, coming soon.