text:
Parking and Transit Information
4/25/13 CRED Symposium at San Jose State University
The Future Real Estate and Space Needs of the Tech Industry in the Bay Area
The event takes place at the Student Union building, in the Northeast section of the campus, near Tenth and San Fernando Streets. Due to construction around the Student Union, the only open entrances to the building are on the north and south sides.
Here is a campus map (pdf)
The parking garages fill up quickly, so guests are advised to arrive before 8:30 am.
There are 3 parking garages on campus. The closest one to the Student Union is the North Garage, on 10th and San Fernando. You will need to buy a day-pass, which is $8. There are machines on some floors in each garage where you purchase a parking permit to display on your dashboard. The machines accept coins, $1, $5, and $10 bills, and Visa/MasterCard.
There are also several parking garages within the vicinity of campus, shown on this map, with more information about the options here.
VTA buses and light rail stop near campus. In addition, there is a free shuttle (DASH) connecting the Diridon Station (Caltrain) with campus.
Map of all transit options near campus (pdf)
Interactive VTA light rail map (closest stations are Santa Clara and Paseo de San Antonio)


text:
16OU161 (Other Keyword)
1-1 (1 Record)
Archaeological Investigations in the Ouachita River Valley, Bayou Bartholomew To Riverton, Louisiana (1983)
DOCUMENT Citation Only
This resource is a citation record only, the Center for Digital Antiquity does not have a copy of this document. The information in this record has been migrated into tDAR from the National Archaeological Database Reports Module (NADB-R) and updated. Most NADB-R records consist of a document citation and other metadata but do not have the documents themselves uploaded. If you have a digital copy of the document and would like to have it curated in tDAR, please contact us at email@example.com.

subset: commoncrawl


text:
22nd April 2005, approximately 21:58. Fifteen year old Edward Upson hits the ball first time from twenty five yards. Andrew McNeill is helpless in the Southampton net. Goal Ipswich Town.
A heartbreaking end to a memorable season for the Saints youngsters, losing the FA Youth Cup final with just two minutes of extra time left to be played.
The first leg had been played at St. Mary's four days earlier, Saints leading through David McGoldrick before being pegged back by a double from Irishman Cathal Lordan, Leon Best netting the equaliser that kept the tie on a knife edge. The second leg had remained goalless despite Saints dominance, Ipswich thankful to keeper Shane Supple that it got to extra time. Seemingly heading for penalties, substitute Upson was the youngest player on the pitch when he stole the headlines, and the silverware for the Suffolk side.
For young lads with the world at their feet, it must have been difficult to take. For some it was to be their career highlight, for others, just the beginning. Football is a cruel world, and as is commonplace, despite being the cream of the crop as young players not all would be destined for the top.
Actually in this instance it was the losers who have fared better, the Saints squad boast four current Premier League players, the Ipswich squad none. While the Saints players have commanded massive transfer fees between them and gained many international caps, the Ipswich team have not. Having said that, not all of the Saints squad has achieved all of their footballing aims.
I decided to find out where they are now, and how different the careers of these players now hitting their peak age of 24/25 have fared.
Andrew McNeil – The Scottish keeper left Saints in January 2006, returning to his native Edinburgh with SPL side Hibernian, he forced his way into the first team at Easter Road, including playing in the 2007 League Cup final win. He was later replaced in the side and released in 2009. He spent a season in the third division with Montrose before signing for First Division Raith Rovers in 2010. He was released by Raith this summer and signed for Livingston where he is currently first choice.
Craig Richards – Local lad Richards was released by Saints in the summer of 2006. He was picked up by Conference side Salisbury City in 2007. Spells at Eastleigh, Bognor Regis Town and Winchester City followed. He now plays for Whitehawk FC in the Ryman League Division One South.
Sebastian Wallis-Tayler – The frenchman left Saints the summer after the Cup Final and signed for Havant & Waterlooville before playing for Bognor Regis Town and Lewes. He is now back in his native France playing for non-league outfit CA Lisieux.
Sean Rudd – After being released by Saints, Rudd had an unsuccessful trial with former club Oxford United before sadly retiring through injury. Now works for a Sports Shoe company.
Martin Cranie – Had already played first team football on loan at Bournemouth and Premier League football for Saints at the time of the Youth Cup final. He played in the Premier League under Harry Redknapp, before finding chances limited under George Burley in the Championship. Cranie had two spells on loan at Yeovil Town before reuniting with Redknapp at Portsmouth for the 2007 season. Spent time at QPR and Charlton on loan before joining Coventry City in 2009 where he is still a regular for the Championship outfit. Has gained caps for England at U21 level.
Lloyd James – The Welsh utility man earned a professional contract with Saints in 2006, and made over seventy first team appearances in the Championship and League One before his somewhat surprise release (having been a regular in the team) in 2010. He soon signed for Colchester United and is now an established member of the U's first team. A Welsh U21 international.
Tim Sparv – Finnish midfielder Sparv left Saints in 2007 to sign for Swedish club Halmstads BK, he is now playing in the Dutch first division with FC Groningen via a loan spell in his home country. He has been capped fifteen times by Finland.
Nathan Dyer – The tiny winger made his first team debut for Saints at the start of the season following the final. He was loaned to Burnley before coming back and getting more regular gametime at St. Mary's. He went on loan again to Sheffield United in 2008, before really flourishing at Swansea City, firstly on loan before joining permanently in 2009 and he is now a regular in their Premier League side.
Theo Walcott – Made his first team debut at sixteen and was soon turning heads at a higher level. Chelsea had already shown an interest in him, but it was Arsenal who paid £5 million with a potential outcome of £12 million (although that is seemingly no longer the case) for him in 2006. He has now played over one hundred times for the Gunners. He became the youngest ever full England international in 2006 and was the surprise inclusion in Sven Goran Erikssons's World Cup Squad of 2006. He has now played eighteen times for his country.
Leon Best – The Irish striker had already played in the Premier League for Saints by the time of the final, and also spent a period on loan with QPR. Further loans with Sheffield Wednesday, Bournemouth and Yeovil Town followed before he rejected a new contract with Saints in 2007 and joined Coventry City, the tribunal setting the fee at £650k. His performances for the Sky Blues were enough to persuade Newcastle United to move for him and is now a first team player with the Toon in the Premier League. He has represented Ireland at senior level.
David McGoldrick – McGoldrick was handed a first team debut in the September following the match at Portman Road, but it would take him another three years and loan spells at Notts County, Bournemouth and Port Vale before he would be considered a regular. He was an ever present in the Saints team that dropped out of the Championship, scoring twelve goals and left for Nottingham Forest for £1 million the following summer.
Kyle Critchell – Defender Critchell was hampered by a serious injury in 2005 and was eventually loaned out to Torquay United in 2006. He was released the following summer and joined Chesterfield. He joined Weymouth in June 2007 before signing for Wrexham the following season, injuries again stunted his progression and he was loaned to York City before rejoining the Terras. He currently plays for hometown club Dorchester Town in the Blue Square South division who he signed for in 2009.
Ashlee Jones – Sub keeper Jones was released in the summer of 2005 and signed for Rushden & Diamonds, he has played for an array of clubs since and eventually made his football league debut for Darlington in 2009, he now plays for Braintree Town in the Blue Square Premier division.
Adam Lallana – The only member of the squad still at St. Mary's, the creative midfielder is now a lynchpin in Nigel Adkins side and has made one hundred and thirty appearances for the club, now catching the eye of Premier League suitors he has been capped at U21 level by England.
Feliciano Condesso – Portuguese midfielder Condesso left Saints in 2007 without playing for the first team, somewhat surprisingly he joined La Liga side Villarreal but couldn't break into the first team setup there either. He played for their 'B' side in the Spanish third tier before joining UD Logrones and now plays for Ontinyent CF.
Gareth Bale – The youngest member of the Saints squad, aged fifteen, Bale made his first team debut in 2006 and played forty times that season as Saints made it to the Championship play offs. Hot property, the likes of Real Madrid and Manchester United were said to be interested, but it was Spurs who signed the Welshman for an initial fee of £5 million that rose to £7 million and Tommy Forescast. Bale struggled to make an impact at White Hart Lane to start with, but is now considered one of the best players in the world. A notable hat trick in the Champions League against Inter at the San Siro propelling him to super stardom. He has played thirty times for Wales.
Josh Dutton-Black – Winger Dutton-Black left Saints in 2007 and signed for AFC Totton. He has since had spells at Salisbury, Kidderminster, Eastleigh, Bognor Regis Town and Didcot Town. He now plays for North Leigh in the Southern League Division One South & West.
Ipswich Town
Shane Supple – Retired. Now a Gaelic Football player.
Michael Synott – Released by League of Ireland side Dundalk in the summer of 2010.
James Krause – Now playing for Cambridge City in the Southern League Premier division.
Chris Casement – Now playing for Linfield in the IFA Premiership. Capped by Northern Ireland.
Aidan Collins – Now playing for the University of London FC.
Sammy Moore – Now playing for AFC Wimbledon in League Two.
Cathal Lordan – Now playing for Cork City in the League of Ireland First division.
Liam Trotter – Now playing for Millwall in the Championship.
Owen Garvan – Now playing for Crystal Palace in the Championship. Eire U21 international.
Liam Craig – Now playing for St. Johnstone in the Scottish Premier League.
Daryl Knights – Now playing for Newport County in the Blue Square Premier League.
Danny Haynes – Now playing for Barnsley in the Championship.
Blair Hammond – Now playing for Ipswich Wanderers in the Eastern Counties League division one.
Charlie Sheringham – Now playing for Dartford in the Blue Square South.
Ed Upson – Now playing for Yeovil Town in League One.
Andy Reynolds – Now playing for Lowestoft Town in the Ryman Premier divsion.
Stuart Ainsley – Now playing for Lowestoft Town in the Ryman Premier divsion.
It is clear to see that the losing Saints squad have, on the whole fared better than their Ipswich counterparts. Although it is staggering to see that of the thirty four players involved, fifteen of them are now playing at non-league level.
This isn't a fate exclusive to these young finalists either, of the 2007 Liverpool winning side, only two players have since played for the first team, and only one (Jay Spearing) is still on the fringe. Their defeated opponents that day Manchester United fielded Danny Welbeck who has now become a first team player, the rest of the names are less familiar. In fact if you were to go through the lineups of all the previous finals, you would find only a handful of players plying their trade at the top of the footballing tree. Another case of foreigners ruining the English game? Hardly. These days half the youth teams are foreign players as clubs look to invest abroad as early as possible, all hoping to discover the next Lionel Messi. The fact is the standard required gets higher every season and more are likely to fall by the wayside with every intake. Also, I always wonder how much difference in ability there is between some players playing non-league and those in the lower echelons of the professional game. Not that much I would wager, and in reality we could probably fill another four divisions of professional clubs if it were possible.
Either way, the differing fortunes of some of these young players is a harsh reminder that the career of a footballer is a privilege to be treasured.
Thanks to Gordon Simpson (Daily Echo), Martin Brodetsky (Oxford United FC), David Seabourne (Bognor Regis Town FC Supporters Club), Graham Large (It's Round & It's White), Jon Dalton (Granley Rovers FC), Samuel Ridout.


text:
(Reuters) - A presidential ethics panel has opened the door to testing an anthrax vaccine on children as young as infants, bringing an angry response from critics who say the children would be guinea pigs in a study that would never help them and might harm them.
The report, however, released on Tuesday by the Presidential Commission for the Study of Bioethical Issues, said researchers would have to overcome numerous hurdles before launching an anthrax-vaccine trial in children. It now goes to Secretary of Health and Human Services Kathleen Sebelius, who will decide whether to take the steps the commission recommended.
Advertisement - story continues below
The one anthrax vaccine approved in the United States, called BioThrax, is made by Emergent BioSolutions Inc of Rockville, Maryland. The company reported $215.9 million in sales of BioThrax, its only licensed product, in 2012.


text:
Hello there, I'm currently trying to assemble a list of all the well known Legend of Cao Cao mods on the site and trying to set up mirrors for the downloads. Currently, I've found:
Fully translated and fully working mods
The base Legend of Cao Cao (obviously)
Legend of Lu Bu
Legend of Jiang Wei
Semi translated/non translated working mods
New Legend of Cao Cao Renewal (untranslated)
Currently, I'm trying to track down links to these mods;
Legend of East Wu
Legend of Heroes (Either the untranslated version, or WaZup's semi-translated version)
I apologize if I've missed any, I'll update this list with new links (if they are needed) periodically. Any help to me in this endeavor will be greatly appreciated.


text:
What are the dangers of having a remote printer?
We have a main office in the city and our wharehouse in in the outer suburbs and daily we print our stocksheets and delivery runsheets via a modem to our printer in wharehouse so storeman can pick orders each day.
Approx 500 pages a day - 6 days a week.
Every week the printer the printer goes offline and im wondering if its being knocked offline by someone or there is a problem with network admin's side who work in the city office section.
There is no computer/monitor with remote printer....just modem and printer.
I know the guys in I.T are very smart and probably have most areas covered for the printer(e.g ports barred) so im just wondering how high is the danger for having it?


text:
This appliance is no longer available. You can still find information and schedule service with the links and tabs below.
To see all our current models, please visit the Wall Ovens page.
This Jenn-Air® luxury double wall oven features the Jenn-Air® Culinary Center, which calibrates the perfect cooking time and exact temperature based on your inputs and preferences. The 7-inch full-color touch-anywhere LCD display makes it easy to select cooking functions like the convenient No Preheat mode.
Floating Glass Black
The Floating Glass series offers a sleek alternative to stainless steel, with a glossy black finish and gently curved handles.
Pro-Style® Stainless
The Pro-Style® Stainless series offers a bold commercial style with heavy-duty knobs and diamond-etched handles.
Euro-Style Stainless
The Euro-Style Stainless series offers clean lines and gently curved handles.
Floating Glass White
The Floating Glass series offers a sleek alternative to stainless steel, with a glossy white finish and gently curved handles.
Connect with a Dealer
Find a dealer
Live Chat with a Customer Care Specialist
Sign up for our newsletter
|Parts & Accessories
|Guides & Manuals
|CAD & Design Files
The Jenn-Air® Culinary Center customizes each cooking cycle based on a variety of your preferences to create your perfect meal. Providing full-color pictures of foods, doneness levels and pan types, the Culinary Center also offers menu-specific cooking tips for optimal results.
The V2™ Vertical Dual-Fan Convection System uses innovative cooking features and technology that combine to help you achieve consistently ideal results.
A full-color LCD display allows the user to touch anywhere on the display to select options that are organized precisely on each screen. The display intuitively presents information to make it easy to get the most out of all of the oven's functions.
Our double and single wall ovens fit into the existing cutout for nearly every competitor's wall oven. Each oven fits into the smallest cutout, while its overall height also allows you to cover the remaining gap in the tallest cutout.
This convenient no preheat mode allows you to bake on a single rack without having to wait for the oven to preheat.
Ideal for entertaining, the upper and lower wall oven each offers generous capacity, allowing you to cook multiple dishes at once.
This double wall oven's superb ventilation allows for closed-door broiling, which ensures consistent cooking. Variable temperature control provides precise heat tailored to different foods and preferences.
This feature offers effortless cleaning and allows you to customize the cleaning level to your needs.
This extendable rack features a smoothly gliding roll-out extension, allowing you to easily position and remove dishes.
My Creations allows you to seamlessly combine up to three cooking modes and save the settings for your favorite recipes.
This convenient feature automatically converts conventional cook time and/or temperature from any recipe to the appropriate convection settings, taking the guesswork out of convection cooking for consistent, effortless results.
Thanks to flush-to-cabinet design, this luxury double wall oven installs flush with surrounding cabinetry, seamlessly integrating for a sleek look.
You'll need an Adobe Reader to download and view pdf files. If you don't already have it installed, you can get it here.
You'll need an Adobe Reader to download and view pdf files. If you don't already have it installed, you can get it here.
Our Service Plan lets you continue to receive in-home repair privileges on your JennAir® appliances even after your regular manufacturer warranty expires.
24/7 Service Hotline
Certified JennAir Technicians
Repair or Replace Feature
Please note: Extended Service Plans are only offered through showrooms. Contact a showroom for more details.
This appliance is no longer available. You can still find information and schedule service with the links and tabs below.
To see all our current models, please visit the Wall Ovens page.


text:
I have tallied the scores and there is a clear winner in my CCC VI Contest Challenge.
First let us go over once more how the points were scored: For each time a team member's name appears in the list of winners and runners up in the CCC VI contest winner's page, that team gains one point. There is no bonus if a team member won the category.
So unless I have made an error, here are the final scores:
Team Mnementh: 5 points (disqualified)
Team JoshWedin: 0 points
Team Bruce_N_H: 6 points
Team Architect: 3 points
Team SavaTheAggie: 3 points (disqualified)
The two disqualified teams were disqualified as per the challenge rules because one of the teams members did not enter any MOCs into the contest. Even including the disqualified teams, however, there is a clear winner.
Congratulations to Team Bruce_N_H!
Bruce will now decide on his teams prize - a special unique forum title of his choosing.
I'd like to thank all who participated, I hope it was a fun experience.
--Tony, Lord Sava of Aggie


text:
Farmers, loggers, truckers and others may face fines of up to $32,500 per day per violation if they do not meet new national standards for the sulfur content of their off-road diesel fuel. The Environmental Protection Agency regulations will be enacted on October 1.
Farmers, loggers, truckers and others may face fines of up to $32,500 per day per violation if they do not meet new national standards for the sulfur content of their off-road diesel fuel. The Environmental Protection Agency regulations will be enacted on October 1.
As part of a nationwide reduction of sulfur in fuel, anyone with storage tanks larger than 550 gallons have until Monday to make sure the diesel fuel in their tanks contains 500 parts per million (ppm) or less of sulfur. The current high-sulfur diesel in those off-road tanks may contain from 2,000 to 5,000 ppm sulfur. Anyone with tanks of less than 550 gallons of capacity have until December 1 to achieve compliance.
In either case, compliance means that the fuel in the tank must be 500 ppm or less. The low-sulfur diesel, also called non-road locomotive marine, or NRLM, is 500 ppm or less, which is the new requirement for off-road fuel, according to requirements passed by Congress in 2005.
"This is going to impact a lot of people," John Mesick of the Dolgeville-based Mesick Oil and Mechanical said. "This is change is going to result in higher costs for everyone, and to make matters worse, many cannot afford to make the necessary changes to reach compliance."
Mesick said his company was one of the lucky ones, as they had the money available to purchase a separate tank for the low-sulfur fuel and a new truck to haul it. "Some fuel companies simply do not have the funds to purchase the equipment needed," he said. "We have been trying to educate our customers, but a lot of people still do not know about the change and many do not realize the fines could be substantial."
Mesick said many fuel providers have started switching customers to the low-sulfur diesel to allow fuel turnover in their tanks to bring them into compliance. He added that the diesel comes with a higher price tag, which has caused a hardship for some.
"This is another unfunded regulation passed down by the government," Mesick said. "Not everyone can afford to pay for a new storage tank or a new truck to haul the fuel, and not everyone can afford to purchase the fuel for their equipment. This is going to hurt people."
The new regulations cover a broad range of non-road diesel fuel uses. Stationary engines built or modified after April 1, 2006, are required to have low-sulfur dyed diesel fuel in their tanks after October 1. High-sulfur fuel (now referred to as heating oil) may continue to be used in older stationary engines installed prior to April 1, 2006. Stationary engines include generators used to create electricity and operate compressors and pumps, including stationary but portable engines used in emergencies. Truck refrigeration units are also required to use low-sulfur diesel after Monday. Pure biodiesel, which is virtually sulfur-free, is considered a compliant fuel under the regulations. However, since most biodiesel is blended with petroleum diesel, those who use biodiesel blends should check with their fuel provider to be sure that the stock is below the 500 ppm limit.
Also under the federal law, dispensers on fixed or skid tanks with a capacity of 550 gallons or greater must be labeled with special decals indicating the sulfur content. The decals must be placed near the dispenser mechanisms. EPA-approved labels are available from fuel distributors.
The sulfur reductions, according to the EPA, are expected to reduce air pollution and improve public health. Further reductions are set for phase-in on June 1, 2010, when the sulfur content for non-road diesel is reduced to a maximum of 15 ppm, the current requirement for on-road diesel.
Anyone seeking further information about the new sulfur regulations should consult a fuel provider.
"My fellow fuel providers and I are trying to get the word out about this change, as many still do not know the change is about to take place," Mesick said. "We want everyone to be in compliance so they can avoid the hefty fines. The changeover is enough of an expense."


text:
Earthquake overview : Tens of people have been killed and hundreds injured during a series of moderate earthquakes in Yunnan, China
Tell us when you think you have felt this earthquake.
China-only earthquake list
Keep this page open to read more details when they become available
Most recent information on top – Start of the article at the bottom
18 school children buried by Yunnan landslide
Nineteen people, including 18 students who followed classes during a China festival week to make up for lost days during the Yunnan earthquake who killed 81 people, were buried in a landslide that occurred on Thursday in southwest China's Yunnan Province, local authorities said. The accident happened around 8:00 a.m. in the village of Zhenhe, located in Yiliang County of Zhaotong City, the county government said.The landslide, estimated to be around 10,000 cubic meters, engulfed a primary school building, trapping 18 students, the government said. Read more ...
Update 09:20 UTC
- People are fleeing their villages for a safer area when heavy rains are raging over Yunnan. China.org writes : A heavy downpour has hit southwest China's earthquake-hit county of Yiliang early Tuesday morning, triggering floods to cut off roads and force thousands to evacuate. The county's headquarter of flood control and drought relief said the rainfall is the largest in local meteorological history. It has damaged the county's drinking water supply pipeline and an alternative water source. The flood is set to delay the post-quake relief work as all roads linking the county with elsewhere have been cut off.
CCTV journalist at work in Yunnan's Jiliang area are witnessing the heavy rains which are generating mudslides. We truly feel sorry for all these earthquake victims who have to find refuge in tented camps with this kind of weather. We expect further video later today and will bring it to you when we notice it.
Update 08:22 UTC
New dangerous earthquakes in Yunnan, China
2 moderate but nevertheless dangerous earthquakes occurred in another part of Yunnan. As the main reason for the damage from lastweek's earthquakes was landslides, it will certainly also be the case here.
11km (7mi) ESE of Dianyang, China. USGS reports a depth of 22 km where CENC reports a depth of 10 km
Early reports are talking about 2 people injured. We are following up the aftermath of these new shakes and will report accordingly.
Update : The number of injured people has increased to 6
Update Sept. 11 - 03:45 UTC
The earthquakes in Yiliang county have caused 257 schools to become damaged containing 98,000 students.
Direct economic losses of up to 582.26 million yuan or around 90 million USD have occurred with schools needing at least 270 million yuan of funds.
Update 16:26 UTC
More than 200,000 children are estimated to have been affected by a 5.7 magnitude earthquake in the South - Western provinces of Yunnan and Guizhou in China.
"Children who have survived this will be frightened and exhausted. We are especially worried about children who may have been separated from their parents during the earthquake, as more aftershocks are expected to hit the area," said Pia MacRae, country director for Save the Children in China.
"Save the Children has projects in the quake-hit area. Our field office team in Kunming is assessing whether to launch a response."
Save the Children has been working in China for nearly 25 years, responding to over 15 disasters in that time, such as the 2010 Yushu earthquake and 2008 Sichuan earthquake.
Update 09/09 - 08:34 UTC
- 293 aftershocks have rattled to damaged area so far
- The direct economic loss estimate from China has hit 3.704 billion CNY or 587 million USD. This is equivalent to 10% of the GDP of the Zhaotong City Prefecture.
- 1.05 billion CNY has been alloted to recovery and relief in Yunnan. (166 million USD)
- The death toll has reduced again after double counting to 81. Injuries are up to 820. 744000 people have been affected.
(彝良县洛泽河镇 - 62 people、角奎镇 - 11 people、龙街乡 - 3 people、荞山乡 - 2 people、龙安乡 - 1 person,昭阳区北闸镇 - 1 person、青岗岭乡 - 1 person.
- In Yunnan, 6650 rooms have been destroyed and over 122000 rooms damaged with 201000 people relocated while emergency forces work.
- In Guizhou, 3 rooms collapsed and 100 rooms have been severely damaged with 380 people relocated.
- Official media are trying to use this disaster as "the best education tool" to be prepared for earthquakes
- Rumors are again increasing misery levels as mouth to mouth information tells them about new earthquakes to arrive soon. Over and over again we have to explain that the strength and timing of earthquakes cannot be fore-casted. All people can do it being prepared to withstand another one. Very rare cases are generating aftershocks that are equal or even stronger than the previous mainshock, but very few chance still means that the chance exists. NEVER believe prophets and continue listening to skilled science people.
- The government will pay pensions as national standard requires it
- Power supply, water distribution and traffic are more or less restored
- Education is still a problem as a lot of school buildings have been damaged and are unfit to receive students. However, the authorities are convinced that some classes can be restarted on Monday
- 34 temporary shelters have been installed to host people with collapsed or unsafe houses
- 43 bodies have been returned to the relatives for burial. The names of these people will be published soon.
Overview Update 13:15 UTC
- Many roads are still blocked because of landslides
- Misery often comes not alone as bad rainy weather is expected for the next 3 days. This will seriously hamper the relief efforts
- After the quake, local authorities have built several temporary shelters at the county square and the county hospital. Relief materials are also arriving. Rescue teams are working around the clock to reach survivors.
- Troops are reporting that rocks are still tumbling down the slopes and mountains which makes repair work very dangerous.
- A lot of Chinese citizens have started to donate money to the Chinese Red Cross. The fund will help to cover urgent needs and medium term aid.
- The death toll has luckily not increased since our morning update
- Damage has also been reported to hydro-electrical installations
- A lot of people have spend the night in tents partly due to their damaged houses and partly because they feel unsafe in their houses as aftershocks are continuing and as people fear another strong earthquake
- Rescue workers are literally moving from door to door to make sure that all damage is reported
- A baby was born in a rescue tent ! A lot of misery and at the same time a sign of hope !
- the United Nations, by means of OCHA, has offered China to assist where they can be helpful
Update 07:11 UTC
- The direct economic loss estimate from China has hit 3.5 billion CNY or 551 million USD.
- This is equivalent to 10% of the GDP of the Zhaotong City Prefecture.
- The death toll has unfortunately risen to 89. Injuries are up to 795. 744000 people have been affected.
Update 21:39 UTC
- We are sad to report that the death toll increased further to 80 people
- The new number of fatalities makes today's earthquake the second deadliest in 2012. Coincidence or not, both these earthquakes were double earthquakes.
Update 16:34 UTC
- More than 1000 military personnel from the Chengdu Military region have been sent to the earthquake area
- Especially the farming community is extremely hard hit by the earthquake
- The Red Cross has started a donation campaign to support the relief efforts
- The city of Chongqing (+30 million inhabitants) has offered to help. Chongqing is approx. 300 km from the epicenter.
- most of the damage has been caused by landslides and not by direct shaking (limited magnitude)
- As the night has fallen in the disaster area, we do not expect to receive as many details as during daylight. The death toll still stands at 64 and we truly hope that it will stop here
- Below one of the latest TV coverages with new footage of the earthquake
Update 14:08 UTC
- It is horrifying for us to add always more and more fatalities in our updates. Now from 63 to 64, another family devastated by losing someone.
- The Yunnan earthquake is currently the 4th deadliest earthquake of 2012
Update 13:05 UTC
- The death toll has, as could be expected, further increased to 63
- 715 people are injured in various degrees
- China Prime Minister Hu Jintao gave personally high priority instructions to do whatever necessary to help the people in the disaster area
- 15 county towns have been damaged in various degrees
- It is currently dark in China and the power has not been restored in all affected areas yet
- 3961 rooms are destroyed
- 13876 rooms damaged
- 3455 livestock pens destroyed
- 11633 livestock pens damaged
Update 10:59 UTC
- A reporter who was inspecting the area saw huge landslides on both sides of the valley.
- Roads are being blocked by huge rocks.
- A boulder measuring 36 meter was blocking the river, creating a small lake
- The houses of 30 families living near a zinc mine have all been damaged
- aftershocks are following each other very fast. More landslides and rockfall is being triggered by the many aftershocks
- rescue workers have still problems to reach some areas as roads are blocked
Update 10:47 UTC
- Most of the fatalities (49 of the 50) have been reported from Yilang county
- The local seismological bureau has given 4 reasons why the death toll is higher in Yilang county
a) very high population density (205 people per sq/km vs 117 in the rest of Yunnan)
b) poorly constructed houses because of poor families and almost no industrial activity (no earthquake resistant building)
c) mountains and slopes which can trigger easily secondary effects like landslides
d) the double strong earthquakes impact. The second earthquake was shallower and closer to densely populated areas
- Experts from CEA (National Earthquake Authority) will arrive soon at the scene to help with the local authorities. National experts are only sent in after major earthquake events.
- High Voltage Power supply facilities have been severely damaged
Update 10:31 UTC
- China TV now reports that 50 people have lost their life in a double moderate earthquake, making this earthquake one of the most deadly this year. Assessment is currently done by the Chinese authorities
- Darkness will set in in a couple of hours making rescue work even more dangerous. Rescuers still have to cope with aftershocks of M3 to M4.
Update 09:20 UTC
- This is the unfolding report of the Yunnan earthquake China, no more updates since our 08:31 UTC report
- More information can come in at any minute
- If you want to know more about this earthquake, please keep this page open and refresh it at regular times as we will continue following up this cruel earthquake the following hours
- Earthquake-Report.com is following up both official information (national and regional seismological bureaus and rescue departments, civil defense authorities as well as Chinese news media)
Update 08:31 UTC
- The death toll of the double M5.6 / M5.7 earthquake has further climbed to 43 (42 in Yiliang County, 1 in Zhaoyang District).
- 700,000 people have been affected by this cruel earthquake
- 100,000 people have been relocated
- Major fires are currently going on in the damaged areas (can be seen on the latest video below)
Update 08:10 UTC
The Yunnan Provincial Civil Affairs department has just released an update :
- 24 dead, 150 injured.
- 100000 people evacuated/relocated
- 20000+ households with damage
- ER expects that the Economic loss estimate is coming out to $220-390 million based on the current parameters. (still waiting on a damage-based estimate).
Update 07:48 UTC
- Apart from the mainshocks, a lot of aftershocks are hitting the area
- The current rainy weather is making the soil very unstable, thus triggering a lot of minor and major landslides
- The Chinese CEA authority has send a 10-man supervisory team to the area. These National teams are only flying in in major disaster cases.
Update 07:40 UTC
- Reports are also talking about severely injured people which means that the death toll will probably climb further
- The news of serious landslides also means that remotely located villages may have been hit by landslides too. Priority is mostly given to the bigger cities.
- Greatly seen in the world as small tremors proof once more to become a deadly cocktail in China. Earthquakes cannot be pinned into a Magnitude / Dangerous relation. Much more has to be accounted for.
Important update 07:33 UTC
- Various Chinese media are now reporting a death toll of at least 20 people. (has to be confirmed by the Yunnan Earthquake Bureau)
- Power has been lost in some areas as transmission poles were knocked down by landslides
- Rail traffic has been halted in the region
- 6,000 tents, 6,000 quilts and 6,000 coats are distributed to the population
- Death toll has reached 7.
- In addition, 20000 households have damage of some form.
- At least 6 are dead according to new reports. The M5.7 earthquake had a 14km depth, and was 15km from Yiliang county and 30 kilometers from Zhaotong City. Damage is expected in both locations.
- The earthquake was felt as far as Chengdu, hundreds of km from the epicenter
Zhaotong Prefecture is home to 5.74 million people but has a reasonably low GDP of around CNY39 billion per year (6.2 billion USD). It is mainly agricultural in nature. The exposed capital stock according to CATDAT in terms of net capital infrastructure is around 14.2 billion USD, of which around 2.1 billion USD is in the most affected areas including Yiliang County. Hence we are looking at a damage bill in at least the 100s of millions of USD if directly impacted. The rural net capita income is about CNY2900 (around 500USD).
UPDATE:- At least 20,000 rooms (around 6,000 houses) are destroyed at first estimates, with 6000 tents being sent to the region and many other disaster supplies.
UPDATE:- The dual quakes hit about 57 minutes apart, both of around M5.6, with much panic.
We are still waiting on damage reports but know that much damage has occurred. More than 150 people from disaster services have rushed to the scene.
Over 6.7 million people live within 100km of this quake. Yiliang county itself has around 500,000 inhabitants and is extremely mountainous having differences of 520m above sea level to 2800m within the county.
51 minutes after the event, 39 people were sent to the area from the Seismological Bureau.
According to Yunnan Yiliang radio and television reporter sent to CCTV's news, a 5.6 earthquake occurred in Yunnan Yiliang, some houses have collapsed and landslides hindered transportation.
Most important Earthquake Data:
Magnitude : 5.7 (CENC), 5.6 (CENC)
UTC Time : 03:19:42 UTC, Friday, 7th September, 2012.
Local time at epicenter : 11:19:42, Friday, 7th September, 2012.
Depth (Hypocenter) : 10km, 10km
Geo-location(s) : 1km (1mi) SW of Jiaokui, China
39km (24mi) NE of Zhaotong, China
84km (52mi) NNW of Weining, China
120km (75mi) SW of Xunchang, China
Links to important maps
Google satellite map showing the epicenter and the surrounding area
Historic earthquakes map
Shaking map
Scientific parameters
Human impact map
Click here for examples of our "earthquake notifications (button below)"
|Refresh this list
|UTC Date/time
|Yunnan, China
|Sep 07 13:13
|Yunnan, China
|Sep 07 05:12
|Sichuan-yunnan-guizhou Rg, China
|Sep 07 05:12
|Sichuan-yunnan-guizhou Region, China
|Sep 07 05:12
|Yunnan, China
|Sep 07 05:12
|Sichuan-yunnan-guizhou Rg, China
|Sep 07 04:16
|Yunnan, China
|Sep 07 04:16
|Sichuan-yunnan-guizhou Region, China
|Sep 07 04:16
|Yunnan, China
|Sep 07 04:16
|Yunnan, China
|Sep 07 04:06
|Yunnan, China
|Sep 07 03:58
|Sichuan-yunnan-guizhou Rg, China
|Sep 07 03:58
|Yunnan, China
|Sep 07 03:58
|Sichuan-yunnan-guizhou Region, China
|Sep 07 03:58
|Yunnan, China
|Sep 07 03:19
|Sichuan-yunnan-guizhou Rg, China
|Sep 07 03:19
|Sichuan-yunnan-guizhou Region, China
|Sep 07 03:19
|Yunnan, China
|Sep 07 03:19
QuakeSOS+ and QuakeSOS free are iPhone applications developed by Armand Vervaeck, the founder of Earthquake Report. The Application simplifies immediate group communication to friends and family members (with your exact GPS location) and is feeding the users with Earthquake Report news. The 0.99 US$ QuakeSOS+ version will support the activities of SOS Earthquakes.
Earthquake-Report.com headlines on twitter
@OnlyQuakeNews : Get all the headlines of our earthquake-report.com articles + regular updates on ongoing events
@QuakeSOS : earthquake-report.com news + automatic earthquake notifications of USGS earthquakes of M 4.0 or higher with emphasis to earthquakes in the America's and the Pacific Ocean sphere (4 and up) and a lot of the rest of the world (5 and up). This account was created for our QuakeSOS and QuakeSOS+ iPhone applications
@ShakingEarth : earthquake-report.com news + automatic earthquake notifications of EMSC earthquakes of M 4.0 or higher with emphasis to earthquakes in European and Asian / Middle East sphere (4 and up) and a lot of the rest of the world (5 and up). This account was originally created to stimulate our Facebook account
@QuakeMaps : earthquake-report.com news with mapping notifications of ALL earthquakes M 3.0 and higher from all over the world via EMSC and USGS. This account was created for our http://www.quake-maps.com website


text:
- 1699 hits
- Education Technology
- 4 years ago
The jobs that the digital natives will be doing to support themselves have not yet been invented.
View More Quotes
Loading quotes, please wait..
Loading quotes, please wait..
|1841 Teachers and parents must also embrace failure as an important learning tool. Staff Editor
|2073 Incorporating the science of learning into our schools would mean that we align curriculum with brain processing information and stop treating learner's brains as if they were all identical or standard. There are no standard brains! Staff Editor
|1388 All children love to learn until this excitement and motivation is schooled out of them. Staff Editor
|1845 Mistakes should not be avoided and are a necessary part of the learning process. Mistakes should be reframed to be misses before the learning takes. Staff Editor
|2085 Learning new ways of implementing curriculum may be messy and appear chaotic, but that's a normal part of the process and change can't happen if we continue to dabble in the safe and secure zone. Staff Editor
BAM Radio hosts 4,369 episodes reaching 7.7 million social media users a month. We're your source for "PD to Go!"
BAM! Radio Network is now the largest all-education talk radio network in the world, offering programming from the nation's top education organizations and thought leaders and reaching a wide audience of people passionately committed to quality education.


text:
100% Secure Shopping
Hello Sign in to your account. New customer? Start here.
Contact Customer service
You have no items in your shopping cart.
About OFG Products
Our Products
My Account
Sign up for a Newsletter
Payments :
Your Customer Reference :
Follow us on :
© Copyright 2020: OFGProducts.com. All rights reserved.


text:
For the longest time I have wished for *some* documentation on how to setup a buildbot slave outside of the Release Engineering setup and not needing to go through the Puppet manifests.
On a previous post, I've documented how to setup a production buildbot master.
In this post, I'm only covering the slaves side of the setup.
Install buildslave
virtualenv ~/venvs/buildbot-slave source ~/venvs/buildbot-slave/bin/activate pip install zope.interface==3.6.1 pip install buildbot-slave==0.8.4-pre-moz2 --find-links http://pypi.pub.build.mozilla.org/pub pip install Twisted==10.2.0 pip install simplejson==2.1.3NOTE: You can figure out what to install by looking in here: http://hg.mozilla.org/build/puppet/file/ad32888ce123/modules/buildslave/manifests/install/version.pp#l19
Create the slavesNOTE: I already have build and test master in my localhost with ports 9000 and 9001 respecively.
buildslave create-slave /builds/build_slave localhost:9000 bld-linux64-ix-060 pass buildslave create-slave /builds/test_slave localhost:9001 tst-linux64-ec2-001 pass
Start the slavesOn a normal day, you can do this to start your slaves up:
source ~/venvs/buildbot-slave/bin/activate buildslave start /builds/build_slave buildslave start /builds/test_slave
This work by Zambrano Gasparnian, Armen is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.


text:
KEY BISCAYNE, Fla. (AP) — Between points, Serena Williams stood motionless behind the baseline with her back to the net, as if trying to match — or mimic — the methodical ritual of her opponent, Maria Sharapova.
They took turns waiting on each other, the pace of play plodding, which only delayed the inevitable. Williams beat Sharapova for the 15th consecutive time Thursday, rallying in both sets to win 6-4, 6-3 in the Sony Open semifinals.
"I have always felt when I'm playing at my best, then it's hard for people to beat me," Williams said.
Rafael Nadal could say the same. He advanced to the semifinals by hitting a flurry of forehand winners down the stretch to beat Milos Raonic 4-6, 6-2, 6-4.
Williams, seeking a record seventh Key Biscayne title, improved to 16-2 against her favorite foil. Sharapova hasn't beaten Williams since 2004.
"Despite my results against her, I still look forward to playing against her because you learn so much from that type of level which she produces," Sharapova said. "You finish the match, and you know where you need to improve and the things that you need to work on."
The No. 1-ranked Williams won with a superior serve and better returns. She hit nine aces and broke five times, which helped her rebound from deficits of 4-1 in the first set and 2-0 in the second.
"I wasn't playing my best," Williams said. "I knew if I wanted to stay in the tournament and make another final, I just had to play better."
She did, earning her 14th consecutive victory against a top-10 player. Her opponent in Saturday's final will be the winner of the semifinal Thursday night between reigning Australian Open champion Li Na and Dominika Cibulkova.
Williams said she wouldn't scout the match.
"I never really watch," she said. "I get too nervous."
The No. 1-ranked Nadal, who is 0-3 in Key Biscayne finals, needs one more win to get there again. His opponent Friday night will be No. 7-seeded Tomas Berdych, who advanced by beating No. 22 Alexandr Dolgopolov 6-4, 7-6 (3).
Nadal has beaten Berdych 16 times in a row over the past seven years.
"This tournament is a tournament where I really feel the love of the people so much," Nadal said, "so I'm going to try my best to keep playing well."
Three-time champion Novak Djokovic will play in the other semifinal Friday against No. 20-seeded Kei Nishikori, who eliminated Roger Federer on Wednesday.
Williams first won Key Biscayne in 2002 and is the defending champion. A minority owner in the Miami Dolphins, she has worn the team's orange and turquoise throughout the tournament she considers her home event because she lives 90 minutes up Interstate 95.
"When I grew up I always wanted to play here," she said. "I guess I just don't want to let go. It's my favorite stop on the tour. It's home. All my friends come. So it's perfect for me."
There was no evidence of a home-court advantage at the start, when Williams failed to convert four early break-point chances and fell behind. Sharapova cracked a succession of winners from the baseline and earned applause from Williams after besting her in one exchange.
While Sharapova is notorious for her deliberate routine between points, Williams doesn't usually play so slowly.
"I just made some errors, and when that happened, I was just trying to regroup and get my mind back together and just try to get back focused and just try to get things going again," she said. "It just helps me to be able to relax. Sometimes I do get a little uptight."
The approach worked. Williams broke back when Sharapova committed three consecutive backhand errors, and gained momentum from there, sweeping the final five games of the first set.
The story was similar in the second set, and after falling behind, Williams resorted to her dominating power. She quickly won one game with two aces and two service winners during a stretch when she swept 11 consecutive points.
"In key moments she served really well today," Sharapova said. "Big serves. I got a few of them, but not good enough to get myself back in the point."
Williams' rhythm and pace improved as the match progressed. She peaked at 122 mph.
"I hadn't been serving great too much this tournament, and then I started serving a lot better today," she said. "I was hitting 120. I was like, 'Whoa. Is that me?'"
Sharapova committed groundstroke errors on the final three points, and a victorious Williams trotted to the net, her left fist leading the way.
KEY BISCAYNE, Fla. (AP) — Between points, Serena Williams stood motionless behind the baseline with her back to the net, as if trying to match — or mimic — the methodical ritual of her opponent, Maria Sharapova.


text:
The 9DBL0853 device is a 3.3V member of IDT's Full-featured PCIe clock family. It supports PCIe Gen1–4 Common Clock (CC) architectures and also supports NVLink applications. The 9DBL0853 device has a Loss of Signal (LOS) indicator to support fault-tolerant, high reliability systems.
For information regarding evaluation boards and material, please contact your local IDT sales representative.
- Loss of Signal (LOS) output; supports fault tolerant systems
- PCIe Gen1–4 CC compliant in ZDB mode
- PCIe Gen2 SRIS compliant in ZDB mode
- Supports PCIe Gen2–3 SRIS in fanout mode
- Supports PCIe SRnS clocking in ZDB or fanout mode
- Direct connection to 85Ω transmission lines; saves 32 resistors compared to standard PCIe devices
- Spread Spectrum tolerant; allows reduction of EMI
- Pin/SMBus selectable PLL bandwidth and PLL Bypass; minimize phase jitter for each application
- Easy AC-coupling to other logic families, see IDT application note AN-891.
- Space saving 6 × 6 mm 48-VFQFPN; minimal board space


text:
Magadh Empire (ROP Faction)
Located on the very edge of the known world, the mysterious jungle realm of the Indians has grown to a great power. The mighty Šišunaga dynasty began to consolidate their realm in northern India, south of the Ganges and expands westwards. Little is known about them. The Greeks say their god Dionysos had come to them teaching them how to cultivate their lands, and later their greatest mythical hero Herakles is said to have reached India as well. However, even the Persians, being much closer in proximity have not yet learned much about the Indian culture. This is about to change. With the Persian Great King Darayawauš (Dareios) expanding eastwards and the Šišunaga expanding westwards, their empires may collide. In any case, the Persians would soon realize how dangerous the Indian military force could be.
Indian warfare developed without much outer influences, unlike many other nations, because the difficult terrain and the natural barriers protecting the Indian subcontinent sealed them off from contact. Yet alone some sporadic nomad incursions brought a few new impulses. Nonetheless, the Indian art of war is very potent. The chief element is fire and movement. The dreaded Indian bamboo long bows have such a devastating effect that neither shield nor armour can offer much protection against them. This bow is almost omnipresent although the nobility is beginning to replace them in favour of the Nomadic composite bows. The reason is not any superiority in firepower, but simply the handling.
The Indian nobles, living for war and not much else, venture the dangers of battle on a light and nimble chariot driven by a trusty servant. Armed with bows they unleash their missiles on the enemy and change position. Some nobles have already begun using elephants, but still the chariot is the symbol of Indian nobility and noble warrior spirit. The secondmost important weapon is the long sword. It is made of excellent metal and widely used after the exchange of missiles. It also has a most powerful impact when handled correctly. Since there is a warrior caste in India, most of them armed with bow and sword, this is often the case.
In general, due to the caste system the Indian warfare is quite professional using battle standards and music to guide their troops during the combat. Indian battle tactics rely on the effect missiles and first attack impetus of their swords to shock the enemy and scatter it's formations. On the other hand the lack of armour or shielding makes them not only fast and manoeuvrable but also very vulnerable. Thus they have an enormous punch but can take only few in return and you need to stay active and dictating the battle. Otherwise, you are lost. That makes the Indian troops quite different to handle.
Of course, the presence of battle elephants is something very special at our timeframe. It's very useful for an Indian commander not only because of the unique availability but also because of his own weakness in horsemen, who cannot stand against any other cavalry. Secthayrabe(utc)


text:
At this time, it is known that IE9 may not work correctly with Webmail Plus, and has a compatibility problem in GoWMU. Putting IE9 into compatibility mode resolves the GoWMU problem. Our software vendors are still recommending IE8.
Firefox 12 has been tested and is approved for use. Firefox 13 may also work. If you upgrade and run into problems, please let the Help Desk know. You may have to go back to FF12.
If you have any questions, please call the Help Desk at (269) 387-4357, option 1.


text:
(Phoenix, Ariz. – Jan. 14, 2010) In response to this week's massive earthquake tragedy in Haiti, many people want to help victims by donating to a charity. Unfortunately, scam artists also emerge during tragic events. Arizona Attorney General Terry Goddard is advising consumers to be cautious when donating to relief efforts and offers these tips when making donations:
- Be skeptical of anyone asking for a donation by requesting your credit card number or bank account information over the phone unless you already donate to that charity.
- Be skeptical of individuals representing themselves as surviving victims or officials asking for donations.
- Make contributions directly to known organizations rather than relying on others to make the donation on your behalf to ensure contributions are received and used for the intended purpose.
- Don't be shy about asking what percentage of your donation will go directly to the charity versus administrative costs.
- Call the Secretary of State's Office at (602) 542-4285 or visit their Web site to make sure the charity is registered with the Secretary of State. A charity that operates without such registration is violating the law and should be seen as a red flag for consumers. Be aware, however, that registration with the Secretary of State does not guarantee that all of the charity's activities are legitimate. Several Web sites, including www.charitynavigator.org, and , provide information on the financial backgrounds of charities. These can be useful for consumers looking to research organizations they are considering for a donation.
- Do not pay bills or invoices you have received from charities unless you know you have already made a commitment to support them.
- Remember to ask for a receipt and a statement that the contribution is tax deductible.
If you believe you have been a victim of fraud, please contact the Attorney General's Office in Phoenix at 602.542.5763; in Tucson at 520.628.6504; or outside the Phoenix and Tucson metro areas at 1.800.352.8431. To file a complaint in person, the Attorney General's Office has satellite offices throughout the state with volunteers available to help. Locations and hours of operation are posted on the Attorney General's Web site. Consumers can also file complaints on line by visiting the Attorney General's Web site at www.azag.gov


text:
Anti-Gay Religious Group: Ill. Marriage Equality Bill Caused Tornados
Last weekend, Illinois was hit by several tornados, causing devastating damage throughout the state. While officials are still calculating the damage, an anti-gay fundamentalist Christian group is claiming the tornados struck Illinois as a result of the state's recently passed marriage equality bill.
According to Right Wing Watch, Robert Ritchie, the executive director for America Needs Fatima, a group created by the conservative American Society for the Defense of Tradition, Family, and Property, claims that the tornados are a result of Illinois' lawmakers green-lighting a bill that provides same-sex couples with marriage rights.
"The massive tornadoes that hit Illinois after the passing of the same sex 'marriage' bill, has stimulated many people to reflection," Ritchie wrote in a blog post. "In it, some see God's chastisement; others see it as yet one more merciful warning from Providence; others yet deny both options and give various reasons."
Anti-gay religious conservatives have linked the LGBT community to natural disasters before. Last year, when Hurricane Sandy struck the east coast, Christian pastor John McTernan claimed the deadly storm was a result of LGBT people and President Barack Obama's support for marriage equality. McTernan said the storm was "the most powerful hurricane on record" that "could do catastrophic damage to the entire Northeast."
Just this week Arkady Mamontov, a prominent Russian journalist, said that the LGBT community was to blame for a meteorite crashing in Chelyabinsk, a city located just to the east of the Ural Mountains and on the border of Europe and Asia, last year.
He said the incident was a warning "to all of us that we should keep the family tradition, traditional love, or else something else - not only the Chelyabinsk meteorite - will hit us."


text:
Mall blues: East end loses another business
December's First Friday will be Sage Moon Gallery's last First. The five-year-old art gallery plans to turn in its keys December 15, and its space joins the neighboring empty storefronts on the 400-block of the Downtown Mall's east end.
"We're sorry, we're very sorry," says co-owner Morgan MacKenzie-Perkins. "We're having to walk away from a big dream."
The gallery at 420 East Main was formerly Grand Piano & Furniture. "This location is large and quite costly," says MacKenzie-Perkins. Rent on the Chuck Lewis-owned, 8,200-square-foot space is over $8,000 a month, she says, and with utilities, comes close to $10K a month. "We can't afford to dip into our pockets any longer," she sighs.
MacKenzie-Perkins blames the economy for shrinking art sales. "People who can afford to collect are holding on," she explains. "It's called fear. We're in a fear mode."
On the upside, "If anyone wants to buy fine art, now is the time to buy," advises MacKenzie-Perkins. Sage Moon will be selling art through December 10.
Despite the Pavilion, Transit Center and controversial 4th Street mall crossing, for which MacKenzie-Perkins was an advocate to help people more easily navigate the mall, the east end has struggled.
Except for a stint as Obama headquarters, the A&N building on the corner of East Main and Fifth Street SE beside Sage Moon has been empty for three years, and in May, Order from Horder across the street at 425 East Main closed its doors and remains unoccupied.
"I never could figure out how that gallery could pay for that space," says developer Oliver Kuttner. As for the east end of the mall, "I don't think it's the beginning of the end, but hard times are coming."
In particular, the city plans to rebrick the mall, which closes outdoor cafes until the work is done in May. "That's the dumbest thing I've ever heard," opines Kuttner. "The city is almost amplifying the negative impact on businesses."
Despite the barren storefronts on the mall– and Kuttner reminds that three buildings beside Wachovia on the west end of the mall have been empty for eight years– "I do know people want to be on the mall," he says. "I get phone calls at least once a month."
Certainly MacKenzie-Perkins intends to return to the mall. For now, she'll hang art at Siips and market through her website. "I think it will turn around," she says. "I believe the whole mall is going to be vibrant when we get through this."
And she urges those who love the mall to shop downtown. "Unfortunately, I think people don't realize they have to spend their money here," she says. "If everyone said, I'm going to do my Christmas shopping here, that would help."
23 comments
It's a shame to see another business leave the mall. I still don't think Charlottesville knows what a gem it has in the pedestrian mall. Just go visit the one in Boulder if you want to see what it can be...
if you dont want this or that what do you want...turn the mall into a nightlife spot like it should be...police get easy collars and the smart ones {whove mastered late night cuban party nose dives and drunken girl panty raids get to well....um co ntinue their 216 boxer and brief brigade...in short be smart the economist werent...
If they had keep the cross street that end of the mall might have had a better chance. The city really screwed that up
Those businesses aren't dying because of a cross street or the lack thereof. It's just a fact that the businesses on the east end of the mall just aren't as inviting, attractive, or hip-happening-now as the businesses to their west.I've walked up and down the mall for 15 years and bet I haven't stepped foot in any of the stores more than once - except for the copy shop that used to be in the garage (is it still there? Haven't noticed).
Is the gallery around the corner from Sage Moon closing, too? It's on the corner of 5th SE and Water. I believe its name is Migration Gallery. Don't forget to count the space in the Market Street parking garage facing the Mall called the City Space as empty. That large space has been used as a rent freebie by the city for years now. Of course the rationale for placing the amphitheater-now-Pavillion and the transit center at the west end of the Mall was to guarantee an increase in business traffic on that end, as if thousands of people do not go in and out of City Hall every month. And we will continue to spend millions of tax payers' money trying to prop up downtown business because the city hasn't learned that there are other forces that have a tremendous impact on business other than government intervention.
The City has done more to promote art than any other town in the state. The blame should not be placed at their feet, George Bush's economy is the culprit.
"The City has done more to promote art than any other town in the state."...
That's a laugh! Look closely in the annual budget and try to find any significant amount of money that goes to promoting the arts. Then look at other areas in VA where the municipalities OWNS the performing art centers, and museums or make significant contributions to them in order to better their cities and towns.
It's an embarrassment that Charlottesville is not one of those cities.
The city owns the MLK Performance Arts Center and the buildings that house the Discovery Museum, the Albemarle Charlottesville Historical Society, the Francis Brand Collection of Firsts, and the McGuffey Arts Center. It also provides hundreds of thousands of dollars a year to pay the real estate taxes for the Paramount Theater (lifetime tax exemption)and the Live Arts and Second Street Gallery complex. Other art groups receive grants when they apply for them. That's a lot on the plate for a town of less than 11 sq. mi.
It is certainly more preferable that the city does not control our art venues or we would have a lot of censorship. The way it is now, art venues can display what they please by any artist they choose.
"George Bushes economy" George Bush didn't tell people to buy their 16 year olds a BMW for their Birthday. George Bush didn't tell you to spend all of the equity in your house on vacations and big screen tvs. The reason a lot of these businesses fail is because the cost of running a business is too high. Start with the rent 12.00 a square foot for that place is at least 20% too much. Add to that all of the burdens of insurance and compliance and the numbers don't crunch. If the city supplied free parking they would more than make it up in sales and income tax. The problem is those taxes don't go directly to the city so there is no motivation. The mall needs lower rents easier parking and more tourist type attractions like a mini musem of Central Va history
It also provides hundreds of thousands of dollars a year to pay the real estate taxes for the Paramount Theater (lifetime tax exemption)and the Live Arts and Second Street Gallery complex."
You'd better do your homework on this issue my friend. That is downlevel information. The Paramount PAYS the city, not vice versa...
During the terms of Kay Slaughter and David Toscano on council the city voted to ignore its moratorium on granting real estate tax exemptions and granted a lifeterm real estate tax exemption for the Paramount Theater. In addition, it gave the organization $35,000 from the Historic Preservation fund to restore the marquee and another $500k to help jump start its fundraising campaign. Now, IF the Paramount has decided to pay its real estate taxes, it does so voluntarily. Perhaps you are confusing this tax with the tax on tickets. When it came time for Live Arts to move, Blake Caravati championed its receiving a lifetime real estate tax exemption also. Council instead voted to assess the tax, then give annual grants to Live Arts to help cover it. Of the $40k assessed the first year, the city covered $10k.
Your facts are impressive, but as I mentioned before a bit outdated. The Paramount is paying its property taxes and not because it has chosen to do so.
Sales Tax on ticket sales is not required under state law I believe for any organization. I could be wrong on that one, I'm not an accountant...
As well they should.
I'm sure the people who ran Sage Moon, or Migration Gallery are very nice people, but Sage Moon in particular didn't have an especially impressive collection of art on display, and the space was huge and uninviting. Orange in an art gallery? Bold maybe, but not high end. It seemed like it was aimed at a unsophisticated middle class first buyer. Not that there is anything wrong with being middle class, or a first time buyer, it just means that business was inevitably going to get tough once the economy took a slight dip. A space one third of that size with focused exhibits might have had a chance. The real deals in art are about to happen when the people who "invested" in art in the last few years realize it is worth only a fraction of what they've paid and try to unload it for anything they can get.
While Sage Moon and Migration are physically close to one another and both sell art, they are very different in character. Migration is small, focused and sophisticated. They show and sell the works of a limited number of artists. Migration seems to place a particular emphasis in helping their customers to understand the art and the artist. They spend time educating and cultivating collectors.
Harry Landers, I agree. I still don't know if they're closing, moving or re-stocking inventory?
Colorado Fan, you're right, the Paramount Theater has given the city money, $221,000 it was assessed as an adjoining property owner to 3rd St. NW, for its share for undergrounding utilities. In 2004, however, then-councilor Kevin Lynch asked if the real estate tax exemption granted by the city to the Paramount coulc be rescinded and was told "No." Can't rescind if not granted.
You're getting warmer...
Oh, did it give the city the rest of the $535,000 that the city gave to it?
Colorado Fan: please simply state what you know of believe you know rather than attempting to poke holes at what someone else is stating. If Cville Eye has incorrect facts/figures, then please tell us what the correct ones are and how we can be sure of your figures rather than Cville Eye's.
I know virtually nothing about the details of any tax arrangements the city has with any of the arts outfits mentioned, but I'm curious. "You're getting warmer..." doesn't help anyone learn anything, though. Granted, perhaps its not your role to educated anyone, but then why post here at all?
Its a crime that the owners of the property charge eight thousand a month to lease the Sage Moon Gallery space. Let it stay vacant. It can't be worth more than two or three thousand, maybe in time the landlords of Charlottesville will quit gouging small business owners and home renters.
GLO, it's not a crime, it's the high cost of paying a mortgage on a multi-million dollar property, real estate taxes, and insurance.
Hey Dr. Hook,
Good review – I like your style in writing. All the clichés` work nicely with the content!! My question is this:
Sugar is the enemy of most diabetics. I am a Type 1 (since 1985) and I'm trying to find a suitable sweetener that will require as little insulin as possible. What are you thoughts on the following: stevia, splenda, and xylitol?
Thanks for your column. Great job!!
Allie Beatty


text:
"Scientists have found preserved proteins in 3.8-million-year-old ostrich eggshells from Africa.
The researchers say these biological building blocks - bound into the eggshell - could provide genetic information up to 50 times older than any DNA.
These proteins, the team said, had been protected because they had been "entrapped" in surface minerals." (Article continues.)
This is the paper in question:
https://elifesciences.org/content/5/e17092 'Protein sequences bound to mineral surfaces persist into deep time.'


text:
Here is free 3D model of a teepee from Indians. Download free STL file of this part and use your 3D printer to make this object. If you liked this 3D object, do not hesitate to post your photos on Cults or to comment in the comments section. The 3D file is 3D printable without any support and it is very easy to print since it is a simple extrusion of a 2D image.
The 3D model was 3D printed on a 3D Flashforge Creator Pro with 10% filling, 2 shells and 0.2mm layer height.
I make very easy to print free 3D designs. No support needed. From 2D pictograms I extrude to have a 3D version. Download my free 3D models in STL format and enjoy 3D printing with your machine!


text: X0306 4 2012-06-29 0000004281 ALCOA INC AA 0001268014 KLEINFELD KLAUS 201 ISABELLA STREET PITTSBURGH PA 15212 1 1 0 0 Chairman and CEO Phantom Stock Units 2012-06-29 4 A 0 830 8.67 A Common Stock 830 19887 D 1 For 1 Phantom stock units were acquired under the Alcoa Deferred Compensation Plan and are to be paid out in cash after termination of employment. The reporting person may transfer the phantom stock into an alternative investment account under the Plan at times permitted under the Plan. As of 06/29/2012, the reporting person also held 3,487.8685 phantom stock units under the Alcoa Deferred Fee Plan for Directors which are to be paid out in cash after Board service ends. Brenda Hart (Assistant Secretary), by power of attorney 2012-07-02


text:
|Sean Carroll
|File size
|File format
Book Description:
Scientists have just announced an historic discovery on a par with the splitting of the atom: the Higgs boson, the key to understanding why mass exists has been found. In "The Particle at the End of the Universe," Caltech physicist and acclaimed writer Sean Carroll takes readers behind the scenes of the Large Hadron Collider at CERN to meet the scientists and explain this landmark event. The Higgs boson is the particle that more than six thousand scientists have been looking for using the Large Hadron Collider, the world's largest and highest energy particle accelerator, which lies in a tunnel 17 miles in circumference, as deep as 575 feet beneath the Franco-Swiss border near Geneva. It took ten years to build and this search has now cost over $9 billion and required the collaboration of engineers from more than one hundred countries. What is so special about the Higgs boson? We didn't really know for sure if anything at the subatomic level had any mass at all until we found it. The fact is, while we have now essentially solved the mass puzzle, there are things we didn't predict and possibilities we haven't yet dreamed. A doorway is opening into the mind boggling, somewhat frightening world of dark matter. We only discovered the electron just over a hundred years ago and considering where that took us--from nuclear energy to quantum computing--the inventions that will result from the Higgs discovery will be world-changing. "The Particle at the End of the Universe" not only explains the importance of the Higgs boson but also the Large Hadron Collider project itself. Projects this big don't happen without a certain amount of conniving, dealing, and occasional skullduggery-- and Sean Carroll explores it all. This is an irresistible story (including characters now set to win the Nobel Prize among other glories) about the greatest scientific achievement of our time.
Download (3.3 MB)


text:
19 yo girl i met on dating site doggystyle Part 4
Gallery gallery type created on rating votes milf roni ford stripps off her panties outdoors 20180713 50000 281 hot roni ford flashing her sexy lingerie in public.
It is great to be adult because you can have unlimited xhamsters british sex it is perfect to have top x live british porn because this free xhamster porn tube shows brittish sex as it is you will find all kinds and sorts of hot british sex movies to fit the taste of any male or female walking on earth.
Good news oldertube and our site maturetubecom are merging oldertube will be closed soon so please go to maturetubecom and enjoy the biggest mature porn collection on the net.
Camsexfreeus webcam live sex cam porn video dating free porno 21 free.
bbw teen 1819 mature tubes granny housewives mom old and housewife tubes porn at older tube real quality comes with age.
Where can you meet real women with all the scams and shady stuff on craigslist where are all the real women at the best thing to do is use a real dating site that is free for basic access to meet local girls.
Xxxmycom is automatic adult search engine using spider script for finding free porn tube clips we refuse owning producing or hosting any adult videos and all clips that you see at the site are nothing but links leading to adult content owned by other websites that are not under our control.
black girl en lingerie sexy i porn video playlist on pornhubcom this lingeries sex collection created by ariarozay1967 contains black girl en lingerie sexy i videos.
hotel hookup porn video playlist on pornhubcom this porn sex collection created by christ0pher contains hotel hookup videos.


text:
Plastic Roll Tubing for insulation of #6 Bonding Braid (800081002) if desired.
Catalog Pages
Plastic Roll Tubing - Catalog
Bonding & Grounding
Bonding Connectors & Bonding Kits
Pair Protectors & Bonding Accessories
Copper Networks
ARMADILLO Stainless Splice Cases
Buried Service Wire Closures
Environmentally Sealed Coax Drop Wire Closure
REDDI Seal & Aerial REDDI Closures
Sub-surface Ready Access Terminal Closures
Cable Demarcation Enclosure
COYOTE Axcess Solutions Pre Terminated Cabinets
Fiber Networks
COYOTE Fiber Optic Closures
COYOTE Closure Series
COYOTE Closures & Splice Cases (OPGW & ADSS)
COYOTE Splice Case Series
FIBERLIGN Splice Case
FIBERLIGN Closure Series
Pole Line Hardware
Ballistic Protection for Splice Case
Cable Storage Systems
Dead-ends & Accessories
Hardware for ADSS
Hardware for OPGW
Hardware for Aerial FTTP Applications
Hardware Accessories (OPGW and/or ADSS)
Lashing Rod
Motion Control Products
Protective Guards & Markers
Spacers & Support
Periodic updates regarding PLP news, product launches and industry insights.
Privacy Policy and Terms of Use | California Supply Chain Act


text:
Thai roast chicken with mango & apple salad
Nutrition and extra info
- Freezable
Nutrition: per serving (without rice)
- kcal275
- fat7g
- saturates2g
- carbs22g
- sugars20g
- fibre4g
- protein33g
- salt0.8g
For the chicken
- 3 shallots, halved
Related to the onion (as opposed to being a younger version of it), shallots grow in clusters at…
- 2 small red chillies, deseeded, half roughly chopped and half finely chopped
- zest and juice 1 lime
The same shape, but smaller than…
- thumb-length piece of fresh root ginger, finely grated
- 2 tsp sunflower oil
Sunflower oil
Sunflower oil is made from pressing sunflower seeds and extracting the oil. It's usually…
- 2 chicken breasts, skin on
For the salad
- 1 red-skinned apple, cut into matchsticks
Grown in temperate regions, apples are one of the most widely cultivated tree fruits. There are…
- ½ mango, peeled and cut into matchsticks
- ½ small bunch mint, leaves picked
There are several types of mint, each with its own subtle difference in flavour and appearance.…
- 3 spring onions, sliced
Spring onionsp-ring un-yun
Also known as scallions or green onions, spring onions are in fact very young onions, harvested…
- small bunch coriander, leaves picked
- ½ tsp fish sauce, plus a splash
Fish sauce
A seasoning often used in Vietnamese and Thai cooking. In Vietnam it is usually made from shrimp…
- ¼ tsp caster sugar
Whizz the shallots in a food processor until finely chopped. Add the roughly chopped chilli, ¾ of the ginger and all the lime zest, then whizz to a chunky paste. Tip into a frying pan with 1 tsp oil and some seasoning, then fry for a couple of mins until fragrant.
Heat oven to 200C/fan 180C/gas 6. Release the skin from the chicken breasts along one side, and stuff with spicy shallot stuffing. Can be done up to a day ahead. Season the skin, then roast in a roasting tin for 15-20 mins until golden, crisp and cooked through. Meanwhile, make the rice (see right).
Toss together the apple, mango, mint, spring onions and half the coriander. Mix the fish sauce, caster sugar, remaining ginger and lime juice, then set aside.
When the chicken is ready, remove it to a plate to rest. Sit the roasting tin on the hob. Spoon off any excess fat, then gently heat, adding the remaining lime juice and a splash more fish sauce, scraping up the chicken juices to make a sauce. Chop the remaining coriander, then stir into the sauce with the finely chopped chilli. Toss the salad with the dressing, then serve with the chicken, sauce and sticky rice.
Recipe Tip
Finish the mangoSlice the remaining fruit, drizzle with a little lime juice, layer in glasses with ready-made rice pudding, then chill until ready to serve. Or, melt brown sugar with a little lime juice in a frying pan, then toss in cubes of mango (or pineapple) until caramelised. Serve hot with a scoop of coconut ice cream.
Recipe Tip
Sticky coconut riceSoften the reserved shallots in 1 tsp oil for a couple of mins, then stir in 1 tbsp creamed coconut and 140g basmati rice. Cover with enough cold water to come 1cm above the surface, bring to a simmer, cover, then cook for 8 mins. Stir (it should be sticky and almost cooked), cover, then leave to stand off the heat for 5 mins.


text:
ADA Casey Novak and ADA Alexandra Cabot will be returning to the courts of New York.
While the cast of the hit show has been playing musical chairs of late, Entertainment Weekly confirmed the two legal ladies will be back for "an undetermined amount of episodes."
Novak (played by Diane Neal) appeared full-time in seasons 5-9, while Cabot (played by Stephanie March) could be seen in seasons 2-4, and part time in seasons 5, 6, and 11.
U.S. & World
Stories that affect your life across the U.S. and around the world.
Christopher Meloni, who played Detective Elliot Stabler, is moving on, though his partner Olivia Benson (the excellent Mariska Hargitay) will be around as a regular.
The show returns this fall for its 13th season, one of two of Dick Wolf's mighty "Law & Order" franchise, the other being "Law & Order: LA."


text:
"Do you ever have one of those days where everything you ever loved as a child was under water?"
Or so wondered Jon Stewart, who returned to "The Daily Show" Wednesday after two nights of previously unscheduled repeats in the wake of Sandy, the post-tropical storm that ravaged the East Coast this week, killing at least 50 people, displacing thousands and causing billions of dollars in damage.
Stewart noted that power was still out in midtown Manhattan, "or, as we refer to it now, Little North Korea."
U.S. & World
News from around the country and around the globe
Louis C.K. makes others laugh in the face of Sandy danger
Among the bits that aired tonight, Stewart dispatched his satirical-news team to different spots around the city, with varying results: Al Madrigal ended up in the midst of a continuing blackout downtown, while John Oliver enjoyed an ice cream sundae uptown and toted a shopping bag from the American Girl store.
"There's two types of folks still down here in No Juice Town — people with machetes, and people without machetes," Madrigal explained when Stewart asked why he was toting, yes, a machete while on the job.
"It's a total hellscape up here," Oliver chimed in. "I don't want to cause a panic, but Serendipity has run out of mocha sprinkles! Which begs the question, where the f--k is FEMA when you need them?!"
Jimmy Kimmel Live aired from Brooklyn last night, with assists from Howard Stern and Tracy Morgan
Ah, socio-politcal commentary at its best.
Stewart also tipped his hat to all the emergency responders and everyone else who has put their safety on the line to provide aid to others, as well as to New Jersey Gov. Chris Christie, who's drawn rave reviews both for his leadership in the storm's aftermath and his decidedly nonpartisan, Obama-appreciating behavior.
He has "kicked crazy ass," Stewart said of Christie, highlighting how antagonistic the governor was toward the president only weeks ago, but how complimentary he's been of him in the last few days.
Lady Gaga laments storm devastation in New York, New Jersey
Samantha Bee also did a little sign language behind him, in the vaunted tradition of NYC Mayor Michael Bloomberg's much-talked-about interpreter for the deaf, Lydia Callis.
"The Colbert Report" also returned to Comedy Central after two nights off (both shows had audiences, BTW) and Stephen Colbert was in top form, telling viewers he hoped they had engaged in his three steps to storm preparation: duct tape the windows, fill the bath tub with fresh water and build an ark.
"Of course, with all this heartbreaking devastation," Colbert said, "there's really only one question on everyone's mind." Cue the newscast clips: "How will this affect election day?"
Morning shows cancel usual Halloween hubbub in Sandy's wake
"This hurricane has got election all over it!" Colbert exclaimed. "Out of sensitivity, less than one week from election day, Mitt Romney has been forced to suspend his campaign. That's why he scrapped his victory rally in Kettering, Ohio, and appeared at a completely different — the same spot with the same people — and called it a 'storm relief rally.' Which is so comforting for all those living on Ohio's hard-hit Atlantic coast."
The Colbert Report
Get More: Colbert Report Full Episodes,Political Humor & Satire Blog,Video Archive
Welcome back, guys, good to have you back.
To contribute to storm relief, text REDCROSS to 90999 ($10 donation) or visit http://redcross.org


text: Because radial shaft seals should never be reused, there is no need to worry about damaging the seal when removing it. However, prior to removal, it is advisable to note the direction in which the seal is installed so that the replacement seal can be installed in the same direction. Small seals can generally be removed using a screwdriver. The removal of large-size seals is made easier if holes have been provided in the housing shoulder (A), allowing access for a drift (fig 1).


text:
Mardome Trade is the standard specification dome unit in our newly redesigned next generation Mardomes.
Providing excellent insulation, triple skin Mardome rooflights achieve a centre pane U-value of 1.8 W/m²K and a Ud-value which ranges from 1.25W/m²K for a 600x600mm dome to
1.51W/m²K for a 1200x2400mm dome.
Higher performance glazing options can further reduce
the Ud-value to as low as 0.95W/m²K¹.
• New contemporary low rise profile
• Saves energy with options to reduce the Ud-value to as low as 0.95W/m²K¹
• Unique glazing cassette in triple and quad skin domes, minimises the risk of condensation
• All power components are hidden for a streamlined lightwell
• Extensive options to satisfy requirements for acoustics, ventilation and light transmission
• For ease of installation the tapered kerb foot does not require timber fillets and an integral membrane clamp holds the roofing membrane or felt in place
Please note: Measurements are taken from internal hole size.


text:
Table of Contents
- What Are Clinical Trials?
- The Basic Components of Clinical Trials
- The Stages of Treatment Trials
- Why It's Important to Participate in a Clinical Trial
- Should I Participate in a Clinical Trial?
- Important Lessons from Clinical Trials
- Clinical Trials and Women Living With HIV
What Are Clinical Trials?
The term clinical trial is used to describe many different types of research studies on human subjects. There are five main types of clinical trials:
- Treatment trials
Study new medications, new combinations of existing medications, or new types of therapies
- Prevention trials
Look for better ways to prevent disease -- sometimes with medicines, sometimes with behavior changes
- Diagnostic trials
Test the best way to detect disease or changes within the body
- Natural History trials
Study the natural course of disease in the human body
- Quality of Life trials
Study ways to improve aspects of life for people living with illnesses
The Basic Components of Clinical Trials
The scientists and health care providers who manage clinical trials are usually called investigators. The people who join clinical trials are usually called participants, but may be referred to as volunteers or study subjects. ALL clinical trials are voluntary – you never have to participate in a clinical trial unless you want to; this is a human right protected by international laws.
In 2002, the World Health Organization (WHO) released a Handbook for Good Clinical Research Practice, which was intended as a guide for each country to develop its own laws governing clinical trials. The WHO's handbook is based in part on the recommendations for good clinical practice set forth by the International Conference on Harmonisation (ICH) in 1996. In the US, for example, the Food and Drug Administration (FDA), which approves drugs for public use, has adopted the ICH's guidance on good clinical practice for clinical trials.
Each clinical trial has a written plan, or study protocol, that describes the goals of the study, how long the study will last, who is eligible to participate (also called inclusion and exclusion criteria), and what tests and procedures are required of each participant.
Inclusion and exclusion criteria are the guidelines used to determine who can and cannot participate in a specific clinical trial. Inclusion criteria are requirements that a person must meet to participate (such as HIV drug-naive, or never having taken HIV drugs, CD4 cell count, viral load, age, or many others). Exclusion criteria are factors that prevent a person from participating either for his or her safety or to make it easier to understand the study results. For example, people might be excluded for having liver problems, or if they have already taken a drug that is being studied.
Each participant in a clinical trial must sign an informed consent. When you sign this document it means that you understand the details of the study and you agree to participate. You may want to take the document with you and talk about the study with your health care provider, family, or friends before you decide to participate. If your native language is not the language spoken by the people describing the study, you should ask if translation is available. It is important that you truly understand the study and what you will be asked to do. If you have any questions, be sure to ask the study staff. It is their job to make sure that, when you sign, you are making an informed choice and understand what you are agreeing to do in signing the document.
You may be paid for travel expenses to and from the study site and for your time; this payment is sometimes called compensation. Childcare may also be provided. You can choose to drop out of a study at any time and for any reason.
The Stages of Treatment Trials
The most common type of clinical trial in HIV is a treatment or drug study. There are four stages, or phases, of clinical trials for new treatments. With each phase, a little more is known about the treatment being studied. Each phase has a different purpose and helps researchers answer specific questions about the drug in trial.
- Phase I: Is the drug safe?
A Phase I trial tests a drug in a small number of participants (usually fewer than 100) to find a safe dose and to document the side effects of the drug. Phase I trials are usually short, lasting a few days to a few weeks.
- Phase II: Is the drug effective?
A Phase II trial tests a drug in a larger number of participants (on average 100 to 300) to see if the drug works. Phase II trials may also test different doses of the drug to find which dose works best. The safety of the drug also continues to be evaluated. A Phase II trial usually lasts six months to one year.
- Phase III: Is the drug safe and effective in larger groups of people for longer periods of time?
A Phase III trial tests a drug in a very large group of participants (typically 1,000 to 3,000). Phase III trials gather more information about the safety and effectiveness of the drug by comparing it to an existing medication or treatment. Phase III trials generally last two to three years.
- Phase IV or Post-Marketing studies:
What are the long-term results of using the drug? These trials are done after US Food and Drug Administration (FDA) approval to get more information about the drug's best use and to further examine long-term side effects.
Once a drug trial has completed the first three phases of research, the company that makes the drug submits the study data to the organization that regulates drugs in that country (e.g., the FDA in the US) for approval. Because the need for treatments for HIV is so great, a drug company can apply for something called accelerated, or quicker, approval if the drug offers something new or meets a need for people living with HIV (HIV+).
Accelerated approval may put special restrictions on how the drug can be used. However, even if a drug gets accelerated approval, the drug company must continue doing long-term research on the drug for it to get full approval.
Why It's Important to Participate in a Clinical Trial
To date, women have been drastically underrepresented in HIV clinical trials. This means that many decisions about women's HIV care and treatment are based on research studies of men. Women are not simply smaller versions of men. Women's bodies are different; consequently, we need women's participation in clinical research to help us understand how HIV acts in the female body.
What are the correct HIV drug dosages for women? How do opportunistic infections and gynecologic problems affect women living with HIV? What side effects are more likely to occur in women than men? Women who participate in clinical trials can help answer many questions specific to women living with HIV while also benefiting the field of HIV research as a whole.
There are many good reasons to participate in a clinical trial. You may:
- Gain access to new treatments not available to the public
- Receive expert medical care at leading healthcare facilities
- Gain access to new experimental medications
- Have a chance to help others by contributing to medical research
Should I Participate in a Clinical Trial?
Choosing to participate in a clinical trial is a big decision. There are risks and benefits to consider when making the choice.
- You may experience unpleasant or serious side effects
- You may have to stop all current medications, including any HIV medications
- You may receive a placebo (a pill containing no medication)
- There is no guarantee that the experimental drug will be an effective treatment for you
- You may experience health benefits from a new treatment that is not yet available to the general public
- Most trials provide free laboratory tests, expert medical care, and drugs at no cost, for the purpose of the study
- You are contributing to the development of a new medication or increasing understanding of HIV disease
Important Lessons from Clinical Trials
Over the past several decades, we have gained important knowledge about the treatment and prevention of HIV through clinical trials research. Here are some of the highlights:
- A combination of HIV drugs (combined antiretroviral therapy) is much more effective at controlling HIV and maintaining good health
- Giving pregnant women HIV drugs can reduce the chances that they will pass HIV on to their babies to as low as one in 100
- Treatment as prevention: For people living with HIV, taking HIV drugs can reduce their viral load, thus making them much less likely to infect others. For people who are HIV-negative, taking HIV drugs can protect them against becoming infected if they are exposed to HIV (e.g, PrEP or pre-exposure prophylaxis).
- The results of a recent study (the START trial) have definitively shown that people living with HIV who start treatment earlier, while their CD4 counts are still high, have a much lower risk of illness and death. This includes people living with HIV who may have no outward signs of ill health.
Clinical Trials and Women Living With HIV
Worldwide, women represent over half of all those living with HIV. In the past, women were excluded from participating in many types of clinical trials. Now, despite being able to participate freely, the number of women participating in HIV treatment trials remains low. A study from 2012 reported that women represented, on average, only one in five participants in clinical trials of antiretroviral drugs approved by the FDA from 2000 to 2008. The good news is that, globally, women's participation in prevention studies, including vaccine studies and behavioral methods, appears higher.
It is important to participate in research because HIV and some of the HIV drugs act differently in women's bodies. The only way to discover these differences is for more women with HIV to join clinical trials. For information on a clinical drug trial in the US that was successful in recruiting large numbers of women and people in color.