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Transport to that island spa of your dreams while unwinding in the master bath. Wash all your cares away with the Birchrose + Co all-natural, deeply relaxing, aromatherapeutic Bath Soak. Take it to the next level and choose a restorative facial sheet mask that will leave your skin feeling sensational.
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An all-natural bath soak that hydrates, rejuvenates, and relaxes the body. Chill and immerse the body in a luxurious aromatherapy experience. Made with organic coconut milk, aloe, sea kelp, and lime essential oil.
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subset: commoncrawl


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How would AI play this?
GuiPerdigao Posts: 12 Just Dropped In
Hello Everyone
Let's say you are playing a team with 3* Black Panther, 3* Iron Fist and some random other hero. Right now you have enough AP and is ready to fire:
-Battle Plan (Yellow BP)
-Rage of the Panther (Black BP)
-Shou-Lao Fang Strike (Green IF)
-Iron Fist of K'un-Lun (purple IF)
If you want to do the most damage (most of times) the best order would be:
-Battle Plan>Shou-Lao Fang Strike>Iron Fist of K'un-Lun>Rage of the Panther
Now if you mess the order the result of output damage would be drasticaly different.
In this kind of scenario, what would AI do?
Would AI aim for best damage done?
Would AI fire the powers in random order?
Does the order I placed the heros would have something to do with this?
Or AI would fire everything whenever it would have enough AP and all this wouldn't ever matter?
This kind of thing keeps me awake at night
Skrofa Posts: 388 Mover and ShakerNormally the AI fires a power as soon as it has enough AP to do so.
If after a massive cascade of sorts the AI gets enough AP to fire more than 1 powers it will do so according to how the colours are lined up in the characters' description. Namely:
Team Up1
Jaedenkaal Posts: 3,356 Chairperson of the BoardsSkrofa said:Normally the AI fires a power as soon as it has enough AP to do so.
If after a massive cascade of sorts the AI gets enough AP to fire more than 1 powers it will do so according to how the colours are lined up in the characters' description. Namely:
Team Up
So, to answer the OP's question, if you somehow ended up with enough AP to fire them all in the same turn, the AI would indeed fire
Battle Plan
Shou-Lao Fang Strike
Iron Fist of K'un Lun
Rage of the Panther
HOWEVER, this also assumes that the team had no other powers in those colors. If it did, the AI might select one of them randomly instead, if it had enough AP to fire them. So if you also had Luke Cage, for example, the sequence might look like:
Yellow: Nothing (saving for Righteous Uppercut)
(No active Red powers)
Blue: Nothing (saving for Defense Grid)
Green: Shou-Lao Fang Strike
Purple: Iron Fist of K'un Lun
Black: Jab, Jab, Cross
Also, note that the AI will only ever fire one power of each color each turn. So even if it had 12 AP, it will never use Jab, Jab, Cross twice in the same turn.
What is still unclear (to me) is how the AI picks which power to (attempt to) fire when there is more than one. I can only assume there's some bias towards higher-AP powers, otherwise you'd almost never see the AI fire the more expensive power in a color with more than one. (Or maybe that's what actually happens, and I've just never noticed)
The other thing to keep in mind is that you as the player might also switch targets in between damage powers in order to maximize the damage done, and minimize over-kill. You'd probably use Iron Fist on the highest-health target first, (which probably isn't your current target), then fire Rage of the Panther. The AI doesn't do this; it will simply fire the power at whoever you left in front. So you can 'bait' the AI into using this combo on someone with only a few hundred health, practically "wasting" the Iron Fist, and also taking 1/3 less damage from the Rage.1


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On large area closes, discover, observe deer, deer, deer, Mouflon, wild boars in their universe and in the evening attend the feeding with Daniel or stone. In this period, birth of calves and piglets. Fishing allowed on pretty little Hills Lake. On-site accommodation.
15892 / 42739 Adverts
Gîte - Self Catering - Small Farmhouse Detached, single storey, separate entrance, in a park
from €108/Night (rates)
from 8 to 14 people 6 adults, 8 children
4 bedrooms
6 roomsLiveable floor area : 150m²
4 bedrooms
6 roomsLiveable floor area : 150m²
ParkingBaby chairBaby bath
Benefits : Stable(s)
- View : Panoramic, unobscured, not overlooked, mountain, forest, nightlights
- Children welcome
- Setting : Calm, Wild
- Forest at <50m
- Thalasso, Spa, Horse riding, Culture, Fishing
- Exposure : South-west
Touristic region : discover Roussillon, Cathar area
Advert No. 22869
For your guidance
Contact by phone
Contact by email
For safety and quality control reasons, we strongly recommend to contact the owner through IHA Holiday Ads.
Reviews about the Advert 22869
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Bergerie du SalbadouAdvert 22869Camps-sur-l'Agly - Aude - France
Theme break
Nature : Discover the fauna
€450 for 14 pers
8 min - 14 max
Indicated duration:
3 days
On request
All year long
Advert details 22869
Assets Farm
Parking : Parking uncovered : internal.
Advantages : Darts, pétanque pitch, pétanque set(s)
baby equipment : Baby chair, baby bath, baby potty
Benefits : Stable(s)
Interior Small Farmhouse with View: panoramic, unobscured, not overlooked, ...
Receive up to : from 8 to 14 person(s) (6 adults, 8 children)
Liveable floor area : 150m²
Interior layout : 6 Room(s), 4 bedroom(s), 2 shower room, 2 WC, living room, large separate kitchen, dining room, tv room, reading room, pantry, veranda
Sleeps - bed(s) : 3 double bed(s), 6 single bed(s), 2 bunk beds, 2 baby cot(s)
Guest facilities : T.V., board games, book collection, t.v points, wifi, wardrobe, cupboard, Hanging wardrobe, safe deposit box, hair dryer, heated towel rail, central heating, wood-burning stove, Glazed in area, Curtains, Double glazed
Appliances : Crockery/cuttlery, kitchen utensils, cafetiere, electric coffee maker, electric kettle, toaster, juicer, food processor, crepe maker, electric raclette set, electric hobs, oven, micro-wave oven, extractor hood, refridgerator, dish washer, washing machine, vacuum cleaner, iron, ironing board
Exterior Gîte - Self Catering in Setting: calm, wild
Ground surface : > 10 ha
Outside accommodation : Covered terrace 8m²
Outside setting : Enclosed grounds > 10 ha, lawn 100m², woods, wells/spring
Outside amenities : Summer living area, BBQ, garden table(s), garden seated area
Rates Calendar Availability Gîte - Self Catering in Camps-sur-l'Agly
Seasons & Availability Small Farmhouse in Camps-sur-l'Agly
Rates Small Farmhouse in Camps-sur-l'Agly
Check-in day
Season Night Weekend week 2 weeks Month
Low season - €450€750 Sat - -
Mid season - €450€800 Sat - -
High season - - €850 Sat€1600 Sat -
Festive specials - - €950 Sat - -
Promotional period - - - - -
ServiceFrequencyIncluded / SuppliedSupplementRates
Sheets1 X / per week€6
Towels1 X / per week€3
Linen1 X / per week€5
Beach towels1 X / per week€3
Cleaning on departure€100
Snow clearance
Baby sitting
Guest table
Half board
Full board
Picnic basket
Themed evening
For your guidance
Information :
Children welcome
Pets accepted under certain conditions (ask the owner)
Present on site : equine animals, wild animals
Mobile telephone network coverage
Water : hot/cold
Local voltage supply : 220-240V / 50Hz
Electricity supply : mains
Booking conditions
Reservation :
Payment made upon reservation : 30% of rental sum
Payment balance : 1 week before the stay
Deposit required : €150
rentals :
Service charges included
Day tax in addition
Cleaning charge levy on departure
Anticipated supplement for : supplementary bed(s), firewood
Accepted methods of payment :
Bank transfer (wire)
Holiday voucher
Leisure, Surroundings, Location House 22869
Leisure Camps-sur-l'Agly - Aude - Roussillon
Specific activities on site or less than 5 km/ 3 miles :
HORSE RIDING Aude
FISHING Roussillon
THALASSO Camps-sur-l'Agly
SPA Camps-sur-l'Agly
CULTURE Languedoc-Roussillon
Leisure activities less than 20 km / 12 miles : Bathing, canoeing, canyoning, rafting, riding school, pony club, pathway, coastal/forest paths, hiking, climbing, mountain bike (path), horse trecking, donkey rides, ATV/Quad Bike, go-karting, hunting, big game hunting, fishing, pétanque pitch
Supervised : Riding school
Attractions and relaxation : Restaurant, cinema, nature reserve, museum, local craftshop, cellar and wine tasting, natural spring baths, thermal baths, thalassotherapy centre, sauna, steam baths, health farm, Bio farm
SurroundingsCountryside - Roussillon
COUNTRYSIDE HOLIDAYS Touristic region : Roussillon
Locality :
Ski slopes
Ski lifts
Ice skating rink
Heated swimming pool
Sea/ocean at 40km
Public swimming pool
Public tennis court
River rapids at 7,5km
River at 7,5km
Stretch of water at 1km
Forest at <50m
Mountain range at 5km
Via ferrata-alpinism at 10km
Amenities :
Town centre at 10km
Bus stop / bus station at 10km
Bike/mountain bike hire at 10km
Household linens for hire/laundry services at 1km
Breadshop at 10km
Local shops at 10km
Supermarket at 10km
Hairdressing salon at 10km
Post office at 4km
Bank at 10km
Cash point at 10km
Doctor at 10km
Nurse at 10km
Hospital at 40km
Location AccessFarm Camps-sur-l'Agly
lieu-dit Le Bouchard Domaine du BOUCHARD
Par Route Du Hameau Des Baillessats Terminus
11190 Camps-sur-l'AglyLanguedoc-Roussillon
GPS coordinates of accommodation
Latitude 42°52'55"N
Longitude 2°26'34"E
Access routes Gîte - Self Catering 22869
at 1h
Airport Perpignan Rivesaltes
Perpignan, Eastern Pyrenees, Languedoc-Roussillon, France
at 1h 15min.
Airport Carcassonne Salvaza
Carcassonne, Aude, Languedoc-Roussillon, France
Towns close by
Camps-sur-l'Agly (1km)
Saint-Paul-de-Fenouillet (12km)
Close to Ruisseau du Cros, Berre, Bois de la Pinede, Chateau Roussillon, Lentilla, Pic de Portepas, Ruisseau del Rieu, Ruisseau de Lasset, Cime des Cunis, Pas de l'Echelle, Bois des Ombres, Cime de Pomarole, Puig Roja, Grau de Maury, Foret du Trabanet, Chateau de Falgas, Bois de Villar, Cap Romarin, Argentdouble, Foret de Lapazeuil, Bois du Vicomte
Towns close by
Nearby places
Photos Farm 22869
View from the property, Small Farmhouse in Camps-sur-l'Agly - Advert 22869 @cc
The house, Small Farmhouse in Camps-sur-l'Agly - Advert 22869 @cc
Overall view, Small Farmhouse in Camps-sur-l'Agly - Advert 22869 @cc
The property, Small Farmhouse in Camps-sur-l'Agly - Advert 22869 @cc
View from the covered terrace, Small Farmhouse in Camps-sur-l'Agly - Advert 22869 @cc
Return to the rental listingsContact


text:
NCBA, PLC Applaud Nomination of David Bernhardt to Be Interior Secretary
WASHINGTON (Feb. 4, 2019) - The National Cattlemen's Beef Association and the Public Lands Council today released the following statement regarding the announcement that President Trump is nominating David Bernhardt to be the next U.S. Secretary of the Interior:
"NCBA has worked very closely with Deputy Secretary Bernhardt over the past two years, and he is an excellent choice to be the next Interior Secretary," said NCBA President Jennifer Houston. "He understands the concerns of cattle producers, and we look forward to continuing our work with him. We hope the U.S. Senate will confirm his nomination as swiftly as possible."
Public Lands Council President Bob Skinner added: "PLC has enjoyed a fantastic working relationship with Deputy Secretary Bernhardt. His knowledge of rural western communities and their relationship to large federal land holdings will be critical to this Administration's ability to continue advancing policies that protect ranchers."
Contact our Media Team
Ed Frank
Senior Director
Policy Communications
Steven Johnson
Associate Director
Policy Communications


text:
Muse -
1. A guiding spirit
2. A source of inspiration
3. Any goddess presiding over a particular art
Introducing Blake Lively...our current Muse of the Moment! You remember her first from Sisterhood of the Traveling Pants and you know her NOW from CW's cult-sensation and killer on-tv wardrobe in Gossip Girl. This stylish gal's sense of fashion doesn't stop when leaving the office, per say! Oh no, no, no! Lil' miss Blake has a sophistication and glam that serious starlets covet and try to emulate but...never...get...right! She does it with ease. Everything about Blake is RIGHT in my book. A quick glimpse and you'll see she continuously chooses a palette that's subdued; blacks, black/white, cream, all white...but still she sparkles and shines, carrying her own with elegant style. She was sporting this long scarf way before other starlets mentioned in a previous post and yep, you knew I was gonna say it next...she's been known to rock a skinny belt, or two, too! So golf claps all around to our Blake...we fell in love with you long ago but are ECSTATIC your style is making waves and garnering adoration from classy women everywhere! Bravo Miss Blake!


text:
Xponential Youth
January 16, 2020 admin Comments Off on Xponential Youth
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- Trust!!!! Who and what can we trust in the post pandemic world with Tariq Qureishy (Futurist, Media & Financial Professional, International Speaker, CEO, Xponential & MAD Group)
© 2020 MAD Group. All Rights Reserved.


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- Review
- Open Access
- Published:
Emerging roles of TRIO and F-actin-binding protein in human diseases
Cell Communication and Signaling volume 16, Article number: 29 (2018)
1106 Accesses
3 Citations
1 Altmetric
TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP variants are broadly classified as variant-1 or − 4 and do not share exons. TRIOBP variant-5 contains all exons. Earlier studies indicated that TRIOBP-4/5 mutation is a pivotal element of autosomal recessive nonsyndromic hearing loss. However, recent studies provide clues that TRIOBP variants are associated with other human diseases including cancer and brain diseases. In this review, recent functional studies focusing on TRIOBP variants and its possible disease models are described.
TRIO and F-actin-binding protein (TRIOBP) was originally identified as a cytoskeleton-associated protein that prompts actin cytoskeletal reorganization and cell proliferation and migration [1]. To date, TRIOBPs have been studied as two distinct variants, TRIOBP-1 or TRIOBP-4/5. In this review, the categories of three major TRIOBP variants for human diseases and subcellular functions are discussed as well as recent associations between TRIOBP and cancer.
TRIOBP variants
TRIOBP is expressed through two promoters and can be classified into three variants (Fig. 1a). The first variant is TRIOBP-5 (218 kDa), the longest transcript in humans, the first promoter that encodes from exon 1 to exon 24. The second variant is TRIOBP-4 (107 kDa), a shorter protein product, that contains the repeat motifs of exon 6 but none of the carboxyl-terminal domains of TRIOBP-5. The third variant, represented by Tara/TRIOBP-1 (72 kDa) [1], is initiated from the second promoter downstream of exon 6. TRIOBP-1 encodes a protein that does not contain the N-terminal repeat motifs but does include the C-terminal domains of TRIOBP-5 encoded by exons 11–24. Therefore, TRIOBP-1 and TRIOBP-4 do not share any exons or amino acid sequences. Overexpression of TRIOBP-1 (also known as TAP68 or Tara) interacts with and stabilizes the actin cytoskeleton in human HeLa cells [1]. TRIOBP-1 is ubiquitously expressed in all tissues, whereas TRIOBP-4 and TRIOBP-5 are predominantly expressed in the retina and inner ear [2, 3].
Role of TRIOBP-4/5 in hearing loss
The phenotype of Deafness, autosomal recessive 28 (DFNB28), is characterized by prelingual, severe to profound sensorineural hearing impairment. In 2006, two research groups found that DFNB28 maps to chromosome 22q13.1 and is associated with TRIOBP-4 and TRIOBP-5 (TRIOBP-4/5) mutations in hearing loss patients in 15 families [2, 3]. To date, in 22 families, all TRIOBP mutations causing human deafness are frequently located in exons 6–9 only in TRIOBP-4/5, but do not affect TRIOBP-1 [4,5,6,7,8] (Fig. 1b).
Inner ear hair cells detect sound through deflection of hearing sensor stereocilia. The stereocilia are linked by rootlets in the cuticular plate of the inner ear (Fig. 2a). The C-terminus of TRIOBP-5, corresponding to coiled-coil domain of TRIOBP-1, is localized at rootlets [9]. Exon 6 of TRIOBP-4/5 encodes several copies of two repeated motifs, R1 and R2; only the R1 motif is the major actin-binding domain of TRIOBP-4/5 [2, 10]. TRIOBP-4/5 is the protein that plays a pivotal role in the formation of rootlets, because Triobp-4 knockout mice cannot form rootlets. In addition, stereociliary fusion in both inner hair and outer hair cells was observed in Triobp-4 knockout mice [11, 12]. The mutations of TRIOBP-4/5 in human hereditary deafness DFNB28 leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.
Role of TRIOBP-1/Tara/TAP68 in disease
TRIOBP-1 (referred to as Tara or TAP68) is associated with regulating actin cytoskeletal organization. To date, the disease relevance of TRIOBP-1 is less clear than that of TRIOBP-4/5. TRIOBP-1 consists of an N-terminal pleckstrin homology (PH) domain and a C-terminal coiled-coil region which is responsible for its homo-multimerization [1, 13]. TRIOBP-1 is ubiquitously expressed in mammalians [2, 3]. To reorganize the actin cytoskeleton, TRIOBP-1 recruits Nuclear distribution element-like 1 (Ndel1) to F-actin structure [14]. Nde1 interacts with TRIOBP-1 to regulate cell migration. TRIOBP-1 is associated with telomeric repeat binding factor 1 (TRF1) and recruits TRF1 and Tankyrase to the centrosome during mitosis [15]. Thr457 of TRIOBP-1 is phosphorylated by Polo-like kinase 1 (Plk1), which plays important regulatory functions during mitosis. The centrosomal localization of TRIOBP-1 depends on the Thr457 phosphorylation. Centrosomal localization of phosphorylated TRIOBP-1 by Plk1 is important for normal chromosome segregation [16]. Moreover, TRIOBP-1 is ubiquitinated by the E3 ubiquitin ligase HECTD3. The ubiquitination of TRIOBP-1 promotes the degradation of TRIOBP-1. The degradation of TRIOBP-1 caused by HECTD3 knockdown mediates genomic instability [17]. These results indicate that regulation of TRIOBP is important for mitotic processes and the cell cycle and may be associated with cancer.
Accumulation of TRIOBP-1 in the brain
Protein aggregations have been shown in the brain of patients with chronic mental illness caused by disruption of protein degradation, specifically, in schizophrenia studies. A monoclonal antibody was found to detect TRIOBP-1 in brain aggregomes exclusively of schizonphrenia patients, and not controls. TRIOBP-1 has a high propensity to aggregate when overexpressed in neuroblastoma cells, unlike TRIOBP-4. Endogenous TRIOBP-1 may also spontaneously form aggregomes in post-mitosis, consistently causing aggregation of TRIOBP-1 in the differentiated neurons [13, 18]. The aggregation property of TRIOBP-1 is caused by the homo-multimerization site (amino acids 324–348) between the first coiled-coil and second coiled-coil domain (Fig. 1c) [13]. These results suggest that TRIOBP-1 aggregation can lead to mental illness.
Oncogenic TRIOBPs in Cancer
A frameshift deletion mutation of TRIOBP was found in one family with gastric and rectal cancer [19]. Although the mutation could not be determined as contributing to cancer, TRIOBP may be a hereditary factor in cancer. TRIOBP-4/5 is significantly upregulated in pancreatic cancer cells and human cancer tissues. TRIOBP-4/5 facilitates the motility of pancreatic cancer cells by regulating actin cytoskeletal reorganization in the filopodia of the cells [20]. TRIOBP-1 is also abundant in adherent junctions and regulates the organization of epithelial cell sheets and integrity by upregulating E-cadherin transcription leading to carcinogenesis [21] (Fig. 2a). Both transcripts and proteins of TRIOBP-4/5 are upregulated in glioma and glioblastoma multiform (GBM) cell lines. TRIOBP-1/5 is significantly upregulated in GBM patients. Specific siRNAs for TRIOBP-4/5 reduced cell proliferation and migration in GBM cells [22]. Interestingly, specific siRNAs for TRIOBP-1 reduced the cell migration and proliferation in human mesenchymal stem cells [23, 24]. The Cancer Genome Atlas (TCGA) analysis also confirms that TRIOBP mRNA is enhanced in most cancer patients (Fig. 2b).
Taken together, these results contribute to the understanding of TRIOBP function in broad tumors. Consequently, TRIOBPs may be a novel diagnostic marker and therapeutic target for glioma and other cancers.
Further focus for TRIOBPs
The oncogenic function of TRIOBPs is poorly understood. Biochemical evidence is lacking to encourage studies regarding this gene. However, recent studies have shown that all TRIOBP variants may contribute to most cancers including GBM. Based on the available data regarding TRIOBPs, in this review we described and associated their characteristics with cellular biology topics, therefore providing several promising aspects for future TRIOBP studies.
Based on previous studies, TRIOBP variants 1/4/5 have different functions. Our recent study showed that all TRIOBP variants are upregulated in GBM [22]. The molecular mechanisms of TRIOBP variants that regulate tumorigenesis are unclear. Interestingly, TCGA data indicate a relationship between TRIOBPs and most cancers. Tissue-specific TRIOBP-4/5 gene is expressed in brain cancers but not in normal brain tissues. Further studies focusing on TRIOBPs as potential cancer biomarkers or regulators of cancer metabolite are necessary [25].
The accumulation of TRIOBP-1 associated with brain diseases such as schizophrenia has been suggested. Thus, further neurobiological studies regarding the effects of TRIOBPs on brain cancer are necessary.
The cellular localization of TRIOBPs is required to determine the specific function of TRIOBPs in subcellular organelles such as centrosomes, telomeres, filopodia, and adherent junctions. In addition, understanding TRIOBP function during the cell cycle such as mitosis or interphase could provide anti-cancer strategies for tumorigenesis.
The first known gene, TRIOBP, to be associated with hearing loss has recently been linked to cancer. TRIOBP variant 1 and TRIOBP variant 4 have been reported to have completely different functions, but both have been found to be associated with cancer. Finally, a new anti-cancer strategy would be identified through a study of the cancer mechanism of TRIOBP variants.
- 1.
Seipel K, O'Brien SP, Iannotti E, Medley QG, Streuli M. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. J Cell Sci. 2001;114:389–99.
- 2.
Riazuddin S, Khan SN, Ahmed ZM, Ghosh M, Caution K, Nazli S, Kabra M, Zafar AU, Chen K, Naz S, et al. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. Am J Hum Genet. 2006;78:137–43.
- 3.
Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lynch ED, Lee MK, Avraham KB, King MC, Kanaan M. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. Am J Hum Genet. 2006;78:144–52.
- 4.
Diaz-Horta O, Duman D, Foster J, Sirmaci A, Gonzalez M, Mahdieh N, Fotouhi N, Bonyadi M, Cengiz FB, Menendez I, et al. Whole-exome sequencing efficiently detects rare mutations in autosomal recessive Nonsyndromic hearing loss. PLoS One. 2012;7
- 5.
Gu X, Guo L, Ji H, Sun S, Chai R, Wang L, Li H. Genetic testing for sporadic hearing loss using targeted massively parallel sequencing identifies 10 novel mutations. Clin Genet. 2015;87:588–93.
- 6.
Naz S, Imtiaz A, Mujtaba G, Maqsood A, Bashir R, Bukhari I, Khan MR, Ramzan M, Fatima A, Rehman AU, et al. Genetic causes of moderate to severe hearing loss point to modifiers. Clin Genet. 2017;91:589–98.
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Wesdorp M, van de Kamp JM, Hensen EF, Schraders M, Oostrik J, Yntema HG, Feenstra I, Admiraal RJC, Kunst HPM, Tekin M, et al. Broadening the phenotype of DFNB28: mutations in TRIOBP are associated with moderate, stable hereditary hearing impairment. Hear Res. 2017;347:56–62.
- 8.
Yan D, Tekin D, Bademci G, Foster J, Cengiz FB, Kannan-Sundhari A, Guo SR, Mittal R, Zou B, Grati M, et al. Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents. Hum Genet. 2016;135:953–61.
- 9.
Kazmierczak M, Kazmierczak P, Peng AW, Harris SL, Shah P, Puel JL, Lenoir M, Franco SJ, Schwander M. Pejvakin, a candidate Stereociliary rootlet protein, regulates hair cell function in a cell-autonomous manner. J Neurosci. 2017;37:3447–64.
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Bao JJ, Bielski E, Bachhawat A, Taha D, Gunther LK, Thirumurugan K, Kitajiri S, Sakamoto T. R1 motif is the major actin-binding domain of TRIOBP-4. Biochemistry. 2013;52:5256–64.
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Kitajiri S, Sakamoto T, Belyantseva IA, Goodyear RJ, Stepanyan R, Fujiwara I, Bird JE, Riazuddin S, Riazuddin S, Ahmed ZM, et al. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell Stereocilia essential for hearing. Cell. 2010;141:786–98.
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Seki Y, Miyasaka Y, Suzuki S, Wada K, Yasuda SP, Matsuoka K, Ohshiba Y, Endo K, Ishii R, Shitara H, et al. A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells. PLoS One. 2017;12
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Bradshaw NJ, Yerabham ASK, Marreiros R, Zhang T, Nagel-Steger L, Korth C. An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure. J Biol Chem. 2017;292:9583–98.
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Hong JH, Kwak Y, Woo Y, Park C, Lee SA, Lee H, Park SJ, Suh Y, Suh BK, Goo BS, et al. Regulation of the actin cytoskeleton by the Ndel1-Tara complex is critical for cell migration. Sci Rep. 2016;6
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Lan JP, Zhu YY, Xu LL, Yu HJ, Yu J, Liu X, Fu CH, Wang XG, Ke YW, Huang H, Dou Z. The 68-kDa Telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis. J Biol Chem. 2014;289:14145–56.
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This work was financially supported by research fund of Chungnam National University in 2015 (Jongsun Park) and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (NRF-2017R1A6A3A11031556, NRF-2016K1A3A1A08953546, NRF-2015R1A2A2A01003597, NRF-2015R1D1A3A01015694).
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Park, S., Lee, H., Kim, M. et al. Emerging roles of TRIO and F-actin-binding protein in human diseases. Cell Commun Signal 16, 29 (2018). https://doi.org/10.1186/s12964-018-0237-y
- Hearing loss
- Cancer
- Actin-binding protein
- Actin cytoskeletal organization
- Tara


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I won his giveaway but he cursed me – Man calls out Tunde Ednut (Video)
A young man, identified as Pablo, called out the Popular blogger, Tunde Ednut for "scamming" him by refusing to pay his cash prize after being declared the winner.
Sharing screenshots of what actually happened as evidence, the young man said that Tunde had asked a question on his page, promising a cash prize of N30k for anyone who got the answer.
The Question was- 'What exact date was Sowore arrested?'
According to Pablo, he had received the answer correctly and also shared a screenshot showing Tunde announcing that he was the winner of the giveaway.
However, he complained that Tunde ignored him when he sent him a DM to ask for his price. After being snubbed for days, he threatened to make it public and Tunde "cursed" him and blocked him.
Watch the video below;


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my dwelling place
The psalm from today's Mass is perhaps the best known of all of the 150 psalms. It is a text known by name, number and popular melody: The Lord's My Shepherd, Psalm 23, often sung to the melody Crimond.
Chances are the moment you hear the words of the psalm a melody comes to mind and you find yourself singing this 2500-year-old prayer.
Set to one of its many popular melodies, this twenty-third psalm is a regular classic at funerals, partly because people of all faiths and of none can easily join in, but also because grieving people know their need to be gently carried through the "valley of darkness and death" to 'God's dwelling place forevermore'.
But more often the words of this prayer give me direction and hope in the midst of daily demands. When I pray with this psalm I can see that it is not about death at all, but about life both now and eternally.
That's the kind of good news that I need every day.
An Invitation
- You'll probably be surprised by how well you know the words of this psalm because you have sung it so often. Take a moment now to recall even a part of the melody and see what words come to mind. I have copied the popular hymn lyrics below to jog your memory, or you might prefer the psalter Grail translation at this link.
- Perhaps two or three words from the psalm come to mind for a reason…perhaps Jesus might be inviting you to stay with a phrase as a mantra for the day.
- If you want to listen on the way to work here are a few musical settings of the psalm: Crimond, Brother James' Air, Anglican Chant & The King of Love.
The Lord's my shepherd, I'll not want;
He makes me down to lie
In pastures green; he leadeth me
The quiet waters by.
My soul he doth restore again,
And me to walk doth make
Within the paths of righteousness,
E'en for his own name's sake.
Yea, though I walk through death's dark vale,
Yet will I fear no ill;
For thou art with me; and thy rod
And staff me comfort still.
My table thou hast furnishèd
In presence of my foes;
My head thou dost with oil anoint,
And my cup overflows.
Goodness and mercy all my life
Shall surely follow me;
And in God's house forever more
My dwelling place shall be.
13 Responses to "my dwelling place"
My guide and mantle through the journey of life.
My soul he doth restore again.
Thank you for these Advent emails. I didn't get around to signing up when I saw the first email although I wanted to. Very grateful to have them start arriving like last year.
There is something in this psalm for everyone.. I lean on the words, "Your rod and your staff comfort me. " The psalmist knew that correction by the shepherd was not about punishment, but comfort.
A beautiful, poignant reflection for our souls at this thought-provoking time of Advent.
A blessing given to me today as I approach surgery tomorrow! I a so looking forward to the pastures green and quiet waters, as my body heals. God is GREAT!
Everything you need is within your Soul
My head thou dost with oil anoint and my cup overflows.
My cup overflows with gratitude and filled with peaceful Presence – nourishing the inner soul.
My soul he doth restore again. I think of this at Communion time, how blessed I am
Hi to Jane who is having surgery tomorrow, thinking of you. I light a candle on my kitchen table and draws me to God and helps me to pray, maybe an Our Father or Hail Mary.
My dear brother-in-law went to God yesterday so the words that really spoke to me were, "And in God's house forever more, my dwelling place shall be." Rest and dwell peacefully dear Gerard.
My dear brother in-law went to God yesterday, so the words that stay with me are. "And in God's house forever more, my dwelling place shall be." Dwell peacefully dear Gerard.
How wonderful it will be when we are dwelling in the Lords House, we can be exactly who He created us to be
To be able to pour out our true selves and receive the total acceptance and love as we are in our deepest being
Oh such joy


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A former executive of a northern Missouri hospital pleaded guilty in federal court in Florida to a $114 million pass-through billing scheme.
The Justice Department in Washington says former Putnam County Memorial Hospital chief executive officer David Lane Byrns pleaded guilty to a one-count information charging him with conspiracy to commit health care fraud. Byrns pleaded guilty before U.S. Magistrate Judge James Klindt, of the Middle District of Florida.
The criminal count was originally filed in Missouri and was transferred to Florida, where Byrns now lives. The complex case was investigated by the FBI in Kansas City, Jefferson City and in Jacksonville, Florida. The Justice Department in Washington has been involved, as has the U.S. Department of Labor and the offices of two Missouri statewide officials.
According to admissions made as part of his guilty plea, in 2016, Byrns and another individual took control of Putnam, a rural hospital in Missouri, through a management agreement with the hospital's board, and Byrns was installed as the hospital's CEO. Byrns and others, including a laboratory owner, then arranged for urine drug tests (UDTs) and blood tests to be performed on a massive scale at diagnostic testing laboratories outside Missouri, on behalf of individuals who were not Putnam patients and who otherwise had no connection to Putnam. To obtain samples for testing, Byrns and his co-conspirators entered into arrangements with marketers, who solicited samples from substance abuse treatment centers, sober living homes, physicians' offices and other sources throughout the United States, in exchange for a portion of the insurance reimbursements. Many of the tests conducted were medically unnecessary. Byrns and his co-conspirators billed the tests to private insurers and to the Missouri Medicaid program using Putnam's billing credentials, in order to take advantage of Putnam's favorable reimbursement rates under its in-network contracts with the insurers, while failing to identify the fact that most testing had not taken place at Putnam, Byrns admitted.
During a 15-month period, Byrns and his co-conspirators caused private insurers and the Missouri Medicaid Program to reimburse Putnam approximately $114 million for the laboratory tests, most of which was shared among Byrns and his co-conspirators, including the laboratories, marketers and billing companies involved in the scheme, Byrns admitted.
The Medicaid program is health care for low-income residents. Unionville is in far north-central Missouri, just south of the Iowa border.
Federal prosecutors in Missouri and Florida say billing companies and labs were also involved in the scheme, describing them as "co-conspirators."
Missouri Auditor Nicole Galloway's (D) scathing 2017 audit of Putnam County Memorial Hospital uncovered $90 million in inappropriate lab billings and prompted calls for the federal investigation.
The Justice Department is acknowledging Galloway's office for assistance, along with Missouri Attorney General Eric Schmitt's (R) Medicaid Fraud Control Unit.


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The Inclusion of Arab Children with Disabilities in Education and Society
11 Arab Countries Have Participated in a Regional TOT Workshop on the Inclusion of Children with Disabilities
ACCD has held a Training of Trainers (TOT) Regional Workshop entitled the "Inclusion of Arab Children with Disabilities in Education and Society" during the period 2-7 April 2016, in partnership and cooperation with AGFUND, LAS, the Arab Scout Organization, the Islamic Development Bank, the Islamic Educational, Scientific and Cultural Organization "ISESCO" and the Kuwait Fund for Arab Economic Development.
The Workshop, during which the Guiding Manual on the Inclusion of Arab Children with Disabilities in Education and Society was implemented, aimed at preparing and rehabilitating trainers on raising awareness of the community, in general, and those concerned with inclusive education in the field of childhood, in particular, as well as to emphasizing the importance and possibility of the inclusion of Arab children in education and society.
More than 65 trainees from 12 Arab countries (Jordan, UAE, Bahrain, Algeria, Saudi Arabia, Sudan, Kuwait, Lebanon, Libya, Egypt, Morocco and Mauritania) have participated in the Workshop, representing teachers and employees in education institutions, experts and workers in the centers specialized in caring for and rehabilitating children with disabilities in the Arab countries.
Participants recommend activating a broader partnership with the Ministries of Education and Colleges of Education, approving the inclusion process as a key component in their programs and ensuring the dissemination of the culture of inclusion
Date: 7 April 2016
Confronting the issue of street children read more
Combating Violence against Children read more
Supporting Civil Society for Children read more
Development of Child Culture read more


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text:
_id: '419'
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text: 'Reciprocity is a major factor in human social life and accounts for a large
part of cooperation in our communities. Direct reciprocity arises when repeated
interactions occur between the same individuals. The framework of iterated games
formalizes this phenomenon. Despite being introduced more than five decades ago,
the concept keeps offering beautiful surprises. Recent theoretical research driven
by new mathematical tools has proposed a remarkable dichotomy among the crucial
strategies: successful individuals either act as partners or as rivals. Rivals
strive for unilateral advantages by applying selfish or extortionate strategies.
Partners aim to share the payoff for mutual cooperation, but are ready to fight
back when being exploited. Which of these behaviours evolves depends on the environment.
Whereas small population sizes and a limited number of rounds favour rivalry,
partner strategies are selected when populations are large and relationships stable.
Only partners allow for evolution of cooperation, while the rivals' attempt to
put themselves first leads to defection. Hilbe et al. synthesize recent theoretical
work on zero-determinant and 'rival' versus 'partner' strategies in social dilemmas.
They describe the environments under which these contrasting selfish or cooperative
strategies emerge in evolution.'
article_type: review
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
ama: Hilbe C, Chatterjee K, Nowak M. Partners and rivals in direct reciprocity.
Nature Human Behaviour. 2018;2:469–477. doi:10.1038/s41562-018-0320-9
apa: Hilbe, C., Chatterjee, K., & Nowak, M. (2018). Partners and rivals in direct
reciprocity. Nature Human Behaviour, 2, 469–477. https://doi.org/10.1038/s41562-018-0320-9
chicago: 'Hilbe, Christian, Krishnendu Chatterjee, and Martin Nowak. "Partners and
Rivals in Direct Reciprocity." Nature Human Behaviour 2 (2018): 469–477.
ieee: C. Hilbe, K. Chatterjee, and M. Nowak, "Partners and rivals in direct reciprocity,"
Nature Human Behaviour, vol. 2, pp. 469–477, 2018.
ista: Hilbe C, Chatterjee K, Nowak M. 2018. Partners and rivals in direct reciprocity.
Nature Human Behaviour. 2, 469–477.
mla: Hilbe, Christian, et al. "Partners and Rivals in Direct Reciprocity." Nature
Human Behaviour, vol. 2, Nature Publishing Group, 2018, pp. 469–477, doi:10.1038/s41562-018-0320-9.
short: C. Hilbe, K. Chatterjee, M. Nowak, Nature Human Behaviour 2 (2018) 469–477.
date_created: 2018-12-11T11:46:22Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2020-07-14T23:07:12Z
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doi: 10.1038/s41562-018-0320-9
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creator: dernst
date_created: 2019-11-19T08:19:51Z
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page: 469–477
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name: 'Quantitative Graph Games: Theory and Applications'
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grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature Human Behaviour
publication_status: published
publisher: Nature Publishing Group
publist_id: '7404'
quality_controlled: '1'
- relation: erratum
url: http://doi.org/10.1038/s41562-018-0342-3
status: public
title: Partners and rivals in direct reciprocity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2018'


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An Axiomatization of Cumulative Prospect Theory for Decision Under Risk
Download full text from publisherTo our knowledge, this item is not available for download. To find whether it is available, there are three options:
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Other versions of this item:
- Chateauneuf, Alain & Wakker, Peter, 1999. "An Axiomatization of Cumulative Prospect Theory for Decision under Risk," Journal of Risk and Uncertainty, Springer, vol. 18(2), pages 137-145, August.
More about this item
KeywordsRISK ; DECISION MAKING ; ECONOMETRICS;
JEL classification:
- C10 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods and Methodology: General - - - General
- C5 - Mathematical and Quantitative Methods - - Econometric Modeling
- D81 - Microeconomics - - Information, Knowledge, and Uncertainty - - - Criteria for Decision-Making under Risk and Uncertainty
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How they work. They are usually fully amortizing fixed rate loans that may have a term of 10, 15, 20 or 30 years. An Interest Only Fixed-rate Mortgage that is amortized over 30 years permits the borrower to pay interest only for the initial interest-only period of 10 or 15 years.
An interest-only mortgage is a type of mortgage in which the mortgagor is required to pay only interest with the principal repaid in a lump sum at a specified date. Interest-only mortgages can be.
For more information on loan types and to determine which interest rate you qualify for, contact a mortgage consultant at 888.457.5626.. Interest only conforming, 3.750%, 4.883%, 0.000. 30-YEAR FIXED RATE GOVERNMENT MORTGAGE.
An interest-only mortgage is a niche product that can be difficult to find these days. See NerdWallet's picks for some of the best interest-only mortgage lenders in 2019 for home buyers in various.
Average Mortgage Rates Over Time Interest Rate For Today If you read or hear about a change to the U.S. Prime Rate, then any loan product that is tied to the Prime Rate will also change, like variable-rate credit cards or certain adjustable-rate mortgages. Click here for more information about how the U.S. Prime Rate works.average home equity Rates Over Time As interest rates continue to rise, the interest rates on home equity loans have generally followed in lockstep with standard fixed-rate mortgage loans, factoring in an added spread due to the increased credit risk that lenders take with home equity products.
In fact, with a 30 year fixed mortgage there are 2 major pros: you get to have a low monthly payment and the interest rate is fixed. Even though a 30 year fixed really only offers the home buyer a low monthly payment, it is one of the most important things to consider when purchasing a home.
Interest only mortgages are structured differently: The most common version pushes back the amortization schedule, usually 5 to 10 years, while the borrower pays interest only. The other type lasts the duration of the loan, with an agreement principal that.
An interest-only home loan can make monthly mortgage payments a lot more. loans were typically adjustable-rate mortgages, not 30-year fixed mortgages.
Interest-only mortgages have much smaller monthly repayments – but the lender will only give you an interest-only mortgage if you have another way of repaying the balance at the end of the term.
40 Year Fixed Mortgage Rates Today · Interest rates on higher-risk fixed mortgages fall – The spread between rates on a two-year fixed rate mortgage at 90 per cent. but remained well below the levels seen a decade ago. Mortgage lending above 90 per cent ltv rose by 40 per cent over the.Who Has The Best Refinance Rates 10 Year Fixed Mortgage Rates | 10 Yr Refinance. – 10-year fixed mortgage rates are a. 10-year refinance rates are. it might require a bit of legwork to track down the best 10 year mortgage rates, and the best.
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Julius Sello Malema,the leader of the Economic Freedom Fighters has divorced his wife,Mantwa Matlala,whom he married in 2014 in a private ceremony under heavy security in his hometown Seshego,Polokwane in Limpopo.
Julius Malema,who has been accused of bedding some of his party supporters and other senior party members,has rubbished allegations by his former wife Mantwa and insisted that she must withdraw her statement or else he is going to sue her for character defamation.
"I'm not saying I'm perfect but I will not buy any of this rubbish levelled against me,she must produce evidence not just barking like a pit bull,where and when did she see me dating my fellow female comrades ?I guess she stumbled upon some of the photos we took after the rally when I was simply hugged by some of our supporters and she decided to conclude that I was dating them,truly speaking comrades I have had sleepless nights with my wife for the past 6 months because of this issue so we have decided to finally call it quits because there is no love without trust",said Malema in a chilling voice.
"This man just want to act all good in public when he's actually a se_xual predator so this time around he must not fool people because I really know his true colors. We did not have peace ever since the day I discovered nu_de photos of him and his girlfriend he claims is just his party supporter,from the look of things the girl was also supporting him even in the bedroom,of which I couldn't tolerate that nonsense",fumed Mantwa and threatens to leak Malema's nu_de photos.
EFF spokesperson,Mbuyiseni Quintin Ndlozi declined to divulge any details and insisted that he has nothing to do with EFF leader's private affair but he is only answerable with things that happens within the party.
- iMzansi


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From Shepherding to Spreading
For Carly and me, our call to ministry came long ago. Before marrying, we both sensed that the best hours of our days and weeks would be devoted to introducing people to Jesus and equipping them in their faith. We've been doing that in various ways for all of our seven years of marriage. For the most part, ours has been a shepherding kind of ministry. We've led small groups, taught classes, led in youth ministry, and for the past three and a half years, I've been a pastor. Yet we sensed Jesus moving us to shift focus. Last spring, when Carly … Continue reading From Shepherding to Spreading


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SACRAMENTO (CBS13) — A coyote feasting on a house cat at H Street and 44th in East Sacramento. It's alarming, but not unusual, according to Jace Huggins with Sacramento Animal Control.
"Mating season was early on in the year and pups are starting to grow up, venture out, and you're going to see more juvenile coyotes out right now. And also, moms and dads making sure they can bring food back," Jace said.
Coyotes aren't new to urban areas. A neighbor posted a picture of a juvenile roaming the campus of Sacramento State just last week.
"Something has been getting my cat. She's gotten three wounds lately. I thought it was a raccoon," said Katina Bostanzoglou.
The animals are active now 24/7, looking for food, and house pets are perfect.
READ: Multiple Reports Of Coyotes Spotted In Midtown Sacramento
"With the young coyotes coming in right now, we're seeing that they've found a food source. They have been consistent and easy and unfortunately, that is pet cats," Huggins said.
Getting rid of the unwelcome visitors requires homeowners to create an unwelcome environment.
"Having an empty soda can and putting a bunch of pennies in it with tape over top. When you see them you shake it really loud, it scares them off," Huggins said.
The city, along with the Front Street Shelter is rolling out an education campaign to inform the public on how to protect pets. The best advice is to keep a close eye on your pets and keep them indoors if possible.


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Review: Three A Light
The innovative growers at Three A Light have a reputation for producing great bud, and lots of it. Their proprietary growing technique has galvanized the grow community and is eloquently explained in their inviting new grow book. It covers everything you need to know from the Schwazze process to helping your plants bounce back even stronger with the proper nutrient levels. I couldn't wait to learn more at their "superfarm" wholesale grow facility. The staff mindfully brought me through a series of over half a dozen rooms to see the various stages of their exclusive grow system. Perfecting how to take growing to another level, this facility, I'm told, often produces close to four pounds per light, or around 150 pounds every two days in their 23,000-square-foot facility. That's literally over one ton of cannabis each month. The people behind Three A Light's grow are passionate about making the most out of their quantity by continuously putting out high-end product that doesn't disappoint.
Thick with terpy aromas, I had to stand back a little to take in the lush wall of Black Ice and Juicy Fruit that surrounded me.
Walking into one of the intricately groomed flower rooms, the towering canopy of luscious colas smelled like an earthy, fruity kush jungle. The ability of the buds to fill in so densely after being schwazzed was incredible and produced some of the juiciest, most compact colas I have ever seen. Thick with terpy aromas, I had to stand back a little to take in the lush wall of Black Ice and Juicy Fruit that surrounded me. Their high output speaks not only to the capability of their in-house success, nutrient line or ground breaking growing methods, but to an element of family that makes the plants and the people better as well.
Greg, Josh, Nick and Max agreed unanimously that the number one concern would always be the culture of Three A Light. "One thing that sets us apart from other companies is our commitment to family," Nick shared. Josh would go on to add, "The most important element at Three A Light is the culture. A lot of us have grown up together. We really are a family and treat it like one." That family vibe certainly carries over to the plant life—they play Marvin Gaye in the nursery while baby cannabis plants are made, and southern gospel hymns to escort out the deceased plants who didn't make the cut. By nurturing the education and success of other growers, the Three A Light family is inspiring many people to see how much more they get out by putting in a little more time, quality and, the most important ingredient of all, some love.


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Who better to tell you to lay off the fatty foods than Jonny Vegas? Who better to recommend cutting down on booze than Gaza? We might listen to them when, in many cases, we would be deaf to a public information message.
Celebrity and advertising go hand in hand. You know you've made it as a celeb when you front the latest denim, makeup, drinks or erm, frozen foods range.
Yet, celebrity endorsed advertising has often been suggested as a sign that the creative team just can't think of a good idea. But there is a time and a place for celebrity in advertising, and, following a recent campaign by Newhaven for the Scottish Government, featuring Gary Newman (of 'Cars' fame), we suggest that it is in social marketing.
Who better to tell you to lay off the fatty foods than Jonny Vegas? Who better to recommend cutting down on booze than Gaza? We might listen to them when, in many cases, we would be deaf to the public information message distributed by a stuffy government. With that in mind, we asked a host of teams to create social marketing campaigns featuring a well-known celebrity. The results are as follows:
We have used Catherine Tate's Lauren character because she epitomises an apathy in today's youth that results in far too many unwanted pregnancies/sexually transmitted infections. She is a character that kids can relate to, without the feeling they are being patronised. Her catchphrase brilliantly sums up the problem we are facing. 'Am I bovvered' adds some humour to what is a very prescriptive message.
OK, hoax calling might be funny, but hoax 999 calls sure aren't. Cue Fonejacker – E4's comedy dialler. Except this time, he's demonstrating the consequences of hoax 999 calls, as we see him make his final call – from prison.
This whole ad is based on the idea that NHS Direct deliver an honest, open assessment of their service and that this openness positions them as an accountable public service. Yes they get it wrong 1% of the time but they're only human. And Conrad Murray is a doctor who very recently got it wrong…allegedly!
Following her slurry outburst on GMTV, this is Kerry Katona's chance to endorse the importance of clarity in language. The fit with the Plain English Campaign not only makes perfect sense but will help give the organisation cutthrough among 12 – 16 yr old cider-swigging-sports apparel-wearing-truants.
"Car sharing" started Adam.
"I fucking hate celebrities" replied Tony.
"We could just take the piss?" Adam suggested.
"Yeah, I fucking hate celebrities" replied Tony.
"Ok, name two that go well together?" asked Adam.
"French & Fry" tittered fat Tony.
"Another pint?" tittered not so fat Adam.
With Timmy Mallet synonymous with bashing children over the head on early morning kids' TV, it seemed quite fitting that he should be against child abuse. Great ambassador for the NSPCC.
"As fires in Scotland increase, the biggest cause of fatal casualties is being overcome by gas or smoke. Over a third of dwellings fires are in homes without a smoke detector and also a significant % where a faulty fire alarm was present. In this campaign, icons tell the viewer what to do, whilst the 'well-kent' face resonates with the audience.
Playing on the fact that his 'X-Men' Superhero character, Wolverine, has 3 giant blades in both of his fists that he can use as and when he feels the need. And there you have your irony, ladies and gentlemen...


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Legendary Dj/Producer may be stuck at home like the rest of us be he is keeping himself busy. Earlier this month, Digweed was among the first to livestream an exclusive 2-hour long set broadcasted directly from his home. The stream garnered over 124,000 views, and led to additional 'Bunker' streaming sessions, which have topped out at well over 600,000 views across the past 10 days. Then he did another 5 hour stream the weekend after. Now he releases his album in title Quattro.
9 months in the making, the album's meticulously assembled exclusive tracks and remixes introduce a range of uniquely exciting new talent alongside many of the label's finest master producers. The album features the likes of Francesca Lombardo, Booka Shade, Tom Mangan, and many more, with the fourth disc mixed in conjunction with fellow Bedrock label-mate Nick Muir.


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Windblade Challenge
What's up everybody? Phase Six Gaming is back with another video. Today's video is my answer to The Windblade Challenge. Windblade's ability to play double pipped cards for free sounded like I perfect match for an Overwhelming Advantage build so I gave it a shot.
YouTube: Phase Six Gaming
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Green arrow comic book series
DC's Green Arrow Getting a New Comic Series | CBRThe Green Arrow has long been a fan favorite character of DC Comics, and thanks to the success of The CW's series Arrow and its many spinoffs, the character is more popular these days than ever before. Fans tune in every week to see what Oliver Queen and company are up to, but like so many characters on television, he didn't get his start there. The Green Arrow has been a member of DC Comics for a long time with many adventures spanning numerous comic books, single issues, graphic novels, trade paperbacks and story arcs having been published since he was first introduced in Over the years, Oliver Queen and his entourage of characters have appeared in thousands of comics, but which ones are the best, and what should you read if you are looking to break into the character? Those questions might be difficult to answer were it not for this very list!
The Best Storylines That Feature Green Arrow
Some good news for Green Arrow fans has arrived. Though the comic by Collin Kelly, Jackson Lanzing, and Javier Fernandez will be ending with issue 50, released in stores today, a new series is in the works. The conclusion of the hero's current story arc marks the end of the Green Arrow 's Rebirth-era run. Not only will a new series be launching, but it sounds like Oliver Queen will be playing a more significant role in the larger DCU. Details have not yet been released regarding when the new series will launch, or who will join the creative team. Via Newsarama.
Find every issue and appearance! Green Arrow first appeared in as a hero in the Batman mold but with a twist — superhero billionaire Oliver Queen wore a costume reminiscent of Robin Hood. He was a popular anthology character in the Golden Age, so much so that Green Arrow continued to appear through the s — generally a barren period for comics. Or, you can start with his relaunch by Kevin Smith , which continued for several years under a number of authors. Alternately, there are two newer points where you can jump in.
Green Arrow has been featured in many ongoing series , limited series and graphic novels published by DC Comics. These titles have been handled or coordinated through a single editorial section at DC Comics. This section also generally handles titles that have spun off of the core Green Arrow titles to feature related characters. This list presents these titles separated by general type of publication. The trade paperback edition of The Archer's Quest 16—21 was released as Volume 4 in the series after Straight Shooter 26—31 was released as Volume 3.
Batman/Green Arrow: The Poison Tomorrow, Green Arrow Secret Files and Origins, December
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Green Arrow Rebirth Vol 1: Death of Green Arrow
Check out the full quiver of Green Arrow comics in chronological order below! Comic Book Herald is reader-supported. When you buy through links on our site, we may earn a qualifying affiliate commission. Any size contribution will help keep CBH alive and full of new comics guides and content. Thank you for reading!
After being shipwrecked on a desert island, wealthy playboy Oliver Queen makes himself a bow and arrows and trains himself to become an expert with them. Whereas Batman could draw from a vast array of items on his utility belt, Green Arrow had an almost inexhaustible supply of trick arrows. After saving a ship that anchors offshore, Queen returns to civilization and embarks on a career as a crime fighter. Sporting a new costume and goatee beard and relieved of his fortune by a crooked business partner, Green Arrow was now a crusader against social injustice. Queen moved to the inner city and met the Black Canary , who would become his love interest for the next few decades.
Green Arrow is a fictional superhero who appears in comic books published by DC Comics. His real name is Oliver Jonas Queen , a wealthy businessman and owner of Queen Industries who is also a well-known celebrity in Star City. He uses this position to hide the fact that he is the Arrow. Though much less frequently used in modern stories, he also deploys a range of trick arrows with various special functions, such as glue, explosive-tipped, grappling hook, flash grenade, tear gas and even kryptonite arrows for use in a range of special situations. At the time of his debut, Green Arrow functioned in many ways as an archery-themed analogue of the very popular Batman character, but writers at DC subsequently developed him into a voice of left-wing politics very much distinct in character from Batman. Green Arrow enjoyed moderate success in his early years, becoming the cover feature of More Fun , as well as having occasional appearances in other comics.
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GSSllp have been commissioned by AW James as Employer's Agent and Quantity Surveyors for the delivery of a new state of the art commercial office building on Avebury Boulevard in Central Milton Keynes.
AW James is a commercial property developer with an existing portfolio of properties in and around Milton Keynes, as well as the UK. The aspiration for this project is a landmark building occupying a prominent position, making it a major contribution to the ongoing development of Central Milton Keynes.
The sustainable, low energy, BREEAM "very good" accredited building will provide eight floors of contemporary space, designed to sit comfortably within the city centre context and utilising high quality materials. The building also boasts its own integral multi storey car park. Comfort and wellbeing have been prioritised with the aim of creating a modern and exciting workplace for all staff, with everything located under one roof.
The building, which is set to become some of the best office and retail space in the area, is expected to be completed in summer 2019. This commission further strengthens our already proven track record in delivering high quality buildings within the commercial property sector.


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Rahul Gandhi signed 'MoU 2008' with China's foreign policy advocacy department
On August 7, 2008 Rahul Gandhi, General Secretary of the Indian National Congress (INC) and Wang Jiarui, Director, International Liaison…Read More »
Did Mumbai Police see Sushant Singh Rajput's body hanging or lying on the bed?
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Open Letter to Superior General Jesuit Curia Fr Arturo Sosa: Mary Rajasekaran is a victim of sexual harassment at Loyola College Chennai
Today is the death anniversary of the Founder of the Society of Jesus – St Ignatius of Loyola. Today is…Read More »
Will India Standup: Mary Rajasekaran is not a celebrity but a simple woman sexually harassed at Loyola College Chennai
Imagine if this happened to you! You gave more than a decade of your life in service to an institution…Read More »
Open Letter to Donald Trump: Investigate Islamic radicals groups in US targeting India to spread terror
Namaste Mr Trump, I admire your fight against terror and I respect that you are a friend of India. Therefore,…Read More »
Is the business of education being reasonable?
That the COVID 19 pandemic is an unprecedented situation for us is not in doubt. That it means our lives…Read More »
You are the 'Devil' the Catholic Church preaches about Bishop Franco
Finally the law is catching up with you Bishop Franco Mulakkal. You are a rape accused. The law might be delayed…Read More »
Xavier Britto are you or are you not the producer of Master?
On October 3, 2019 Xavier Britto's XB Film Creator kick-started an untitled Joseph Vijay project with a formal Pooja ceremony…Read More »
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It appears that the World Health Organisation (WHO) continues to function under the shadow of the dictates of the Chinese…Read More »
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Huawei CEO Ren Zhengfei sent a shocking reality check disguised as an internal memo on Tuesday, as the company reeled from the implications of the latest move from the U.S. Commerce Department. Ren warned of job and salary cuts and the need for employees to hunt out new roles and to make sure they're being useful to the company, or they will face the consequences.
Many of Monday's headlines had focused on the 90 day extension of the "temporary license," pushing the full-scale U.S. supplier ban to November. But the U.S. has also identified a further 46 Huawei affiliates which have been added to the entity list. And, according to reports, those affiliates—overseas subsidiaries and the like—have proven useful in making purchases from U.S. suppliers.
"We oppose the U.S Commerce Department's decision to add another 46 Huawei affiliates to the Entity List," the company said in its formal response. "It's clear that this decision, made at this particular time, is politically motivated and has nothing to do with national security—we call on the U.S. government to put an end to this unjust treatment and remove Huawei from the Entity List."
While the world focused on the extension, the company focused on the expansion—read into that as you will.
Such analysis was supported by Ren's Tuesday memo to employees, warning of the change to their world. The company, Ren warned, is at a "live or die moment," as the U.S. tightens its noose. According to a Bloomberg, the memo tells employees to find useful projects, find other roles, or find themselves in trouble. "They either form a 'commando squad' to explore new projects—in which case they could be promoted to company commander if they do well. Or they can find jobs in the internal market. If they fail to find a role, their salaries will be cut every three months."
The militaristic language will not help Ren's case with his U.S. detractors, who question whether his past links to China's military still persist, and whether this affords the Chinese state influence over the company and its overseas activities.
The glitzy launch of Huawei's new HarmonyOS earlier was just two weeks ago—it seems much longer. The truth is, that despite the fanbase analysis and the thousands of developers thrown into its development, HarmonyOS is no replacement for Android. This isn't a technical challenge that can be addressed with short-term investment. It has taken Google (and Apple) more than a decade to build out their smartphone ecosystems. When was the last time you switched from Android to iOS or vice versa? Fancy doing it again? Imagine asking hundreds of millions to do that within a short space of time. To replace their app purchases, if those apps even exist.
And so, again, it's all about the Chinese giant's smartphone business. The driver of growth, accounting for approaching half the business, a reinvention from network champion to consumer brand, now facing an uncertain future at the hands of the U.S.
The company has a loyal and hard-won fanbase of customers and analysts around the world, and this fanbase wants to believe that everything will be okay and the company will find a way through. But the stark reality for Huawei is that it cannot continue to churn out shiny new smartphones without a ready customer market. While the basic Android is open source and available to all, it comes without the Google add-ons. And creating an alternative—the recently launched HarmonyOS for example—means starting from scratch to build a competing ecosystem. It will take years.
Huawei hopes to hang onto its number two slot for smartphone shipments this year, but despite a strong first quarter its sales were hit in the second quarter and are likely to be hit further in the latter half of the year. The question is how long can it string out its supply chain access with the extended entity list—does it have the stockpiles to meet its plan for launches and shipments through the end of the year?
Smartphone shipments fuelled Huawei's growth last year and had been set to do the same this year. It has an enviable balance sheet and a protected market in China, but it aspires to maintain its global position.
November is not far away. Huawei will move mountains to ready itself for what happens next. As things stand, the signals from the U.S. are that there will not be a further extension, that this is to enable customers to "wean themselves off" the Chinese company's tech. And an end to the reprieve will hit like a guillotine.
Last week, Huawei CEO Ren Zhengfei warned the U.S. that Huawei will set out to break the dominance enjoyed by Google (and Apple) over the world's smartphone ecosystem. "If the U.S. government does not allow Google to provide the Android operating system," Ren told Sky News, "then the world may have a third operating system—and that is not in the best benefit or interests of the United States."
We may soon find out how that actually works in practice.
I am the Founder/CEO of Digital Barriers—developing advanced surveillance solutions for defence, national security and counter-terrorism. I write about the intersection…
I am the Founder/CEO of Digital Barriers—developing advanced surveillance solutions for defence, national security and counter-terrorism. I write about the intersection of geopolitics and cybersecurity, and analyze breaking security and surveillance stories. Contact me at email@example.com.


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Cottage Jasmina
Sheltered between Loulé's spectacular countryside with commanding views across the Algarve.
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Welcome to this unique two bedroom cottage. Just 10 mins from the busy market towns of Loulé the cottage is very private and is a separate part of Villa Jasmina, a very exclusive five bedroom villa.
The cottage has its own private swimming pool, terraces and a beautiful water pond. Set amongst the hills and valleys in a protected environmental zone it offers walking, cycling, bird watching and quick access to glorious sandy beaches. The cottage is close to many traditional and stylish restaurants. Fresh fruits, fish and vegetables are available every morning in the nearby local markets.
Fully air conditioned
Flat screen TV
DVD Player
Private Pool
Balcony / Terrace