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membrane proteins -- physiological transport. ; biological transport -- regulation. ; cell membranes. ; golgi apparatus. ; endoplasmic reticulum. ; saccharomyces cerevisiae -- cytology.
microbial enzymes -- structure. antiprotozoal agents -- design. toxoplasma gondii. guanosine triphosphatase -- structure. g proteins -- structure. thymidylate synthase-dihydrofolate reductase -- chemistry. dynamins -- chemistry.
membrane fusion. ; tonoplasts. ; plant vacuoles. ; saccharomyces cerevisiae -- molecular aspects.
membrane fusion. membrane proteins -- physiological transport. yeast fungi -- cytology. medical term vacuoles -- metabolism. cytoplasmic vesicles -- metabolism rab gtp-binding proteins -- metabolism proteolipids -- metabolism
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The novel p53 target gene STK17A : implications for cancer therapy / by Pingping Mao
Testicular germ cell tumors (TGCTs) are highly curable with cisplatin-based therapy. The p53 tumor suppressor is induced in response to a variety of cellular stresses. Our previous work has implicated an important role for p53 in TGCT...
Dartmouth Dissertations
Coupling of termination, 3' processing and mRNA export.
Messenger RNA -- Genetic aspects. ; Transcription factors. ; Genetic transcription -- Regulation. ; RNA-protein interactions. ; Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations
FGF2 in endothelial cell migration, intracellular signalling and receptor endocytosis.
Fibroblast growth factors. Rho GTPases. Cell receptors. Integrins -- Physiological effect. Endocytosis. Vascular endothelium. Cellular signal transduction.
Endothelial cell migration is an important element of a number of biological processes, including angiogenesis. The fibroblast growth factors (FGFs) are a family of angiogenic heparan-binding proteins that potently induce endothelial migration....
Dartmouth Dissertations
Host immune responses in a non replication model of Toxoplasma gondii infection.
Toxoplasmosis -- Immunotherapy. Toxoplasma gondii -- Pathophysiology. Immune response -- Regulation.
Toxoplasma gondii is a highly successful obligate intracellular parasite capable of infecting humans and poses a significant health threat to people with AIDS and who are immunosuppressed. Infection with T. gondii involves a highly complex...
Dartmouth Dissertations
Mechanistic insight as to how the formin FMNL3 assembles filopodia / by Ernest G. Heimsath, Jr.
Actin filaments are integral to a large number of cellular structures. Due to the widespread use of actin, cells must rigorously control when and where new filaments assemble. Formin proteins are expressed in all eukaryotes and provide the...
Dartmouth Dissertations
Coordination of cell proliferation and cell fate determination by C. elegans CES-1 Snail / by Bo Yan.
Cyclin-dependent kinases (CDKs) and their associated cyclins are key regulators of cell cycle progression. Caenorhabditis elegans has two predicted A- type cyclins, encoded by the genes cya-1 and cya-2. Cyclin A has been shown to be required for...
Dartmouth Dissertations
Small molecule modulation of morphology and metabolism in Candida albicans / by Allia Kaye Smith
Candida albicans is a fungal species that naturally exists as a commensal member of the human microbiota, but can assume a pathogenic lifestyle and subsequently induce life-threatening systemic infections. The ability of the fungus to grow in...
Dartmouth Dissertations
Characterization of two S. Cerevisiae genes implicated in mRNA export: RAT7, encoding a novel nuclear pore complex protein and NPL3, encoding a putative hnRNP protein.
Messenger RNA -- Genetic aspects. Proteins -- Synthesis -- Genetic aspects. Saccharomyces cerevisiae -- Genetics.
Dartmouth Dissertations
Discovering MII1 regulated pathways in hematopoietic stem cells.
Hematopoietic stem cells. ; Hematopoietic stem cell disorders -- Genetic aspects. ; Genetic transcription -- Regulation. ; Leukemia -- Genetic aspects. ; Cell proliferation. ; Myeloid-Lymphoid Leukemia Protein -- genetics.
Hematopoietic stem cells (HSCs) balance self-renewal with the continuous production of the suitable numbers of lineage-restricted progenitor cells. In this work we demonstrate that the Mixed lineage leukemia 1 (Mll1) gene is essential for this...
Dartmouth Dissertations
A novel role for visual arrestin in endocytosis-mediated retinal degeneration.
Phospholipase C -- Mechanism of action. Retinal degeneration -- Pathophysiology. Retinal degeneration -- Genetic aspects. Endocytosis. Rhodopsin. Cellular signal transduction. Light -- Physiological effect. Arrestin. Clathrin. Adaptor Proteins
Mutations in the Drosophila retinal-specific Phospholipase C (NORPA) cause massive retinal degeneration within five days of constant light exposure. We have previously shown that in norpA mutants persistent complexes between the light receptor...
Dartmouth Dissertations
Biochemistry of isolated sea urchin mitotic apparatuses: protein phosphorylation and the control of mitosis.
Mitosis. ; Phosphorylation. ; Sea urchins -- Embryos.
Dartmouth Dissertations
The study of an endonuclease and its potential role in apoptosis.
Deoxyribonucleases. ; Endonucleases. ; Apoptosis.
Previous work in this laboratory has implicated deoxyribonuclease II (DNase II) as an endonuclease responsible for DNA digestion during apoptosis. The goal of this thesis was to isolate the cDNA encoding DNase II and study its potential role in...
Dartmouth Dissertations
Targeting G1 cyclins in cancer chemoprevention.
Bronchi -- Cancer -- Chemoprevention. ; Cyclins. ; Retinoids -- Therapeutic use. ; Cellular control mechanisms. ; G1 Phase.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer treatment and chemoprevention. There is a need for an in-depth understanding of the mechanisms that account for retinoid response or resistance in lung cancer...
Dartmouth Dissertations
Role of Erv14p in vesicle mediated protein transport from the endoplasmic reticulum to the Golgi in Saccharomyces cerevisiae.
Membrane proteins -- Physiological transport. ; Carrier proteins. ; Biological transport -- Regulation. ; Saccharomyces cerevisiae -- Cytology. ; Golgi apparatus. ; Endoplasmic reticulum.
Transport vesicles form at a donor compartment and fuse to an acceptor compartment mediate the movement of cargo proteins within eukaryotic cells from one subcellular compartment to another. COPII vesicles specifically provide the means of...
Dartmouth Dissertations
Investigating the role of ARP2/3 complex and formins in assembly of cell surface protusions.
Cells -- Motility. Cell membranes -- Formation. Cytoskeletal proteins. Actin. Cell Movement -- physiology. Actin-Related Protein 2-3 Complex -- physiology. Microvilli.
Despite years of study, the mechanisms by which cells protrude their leading edge during cell motility are still highly controversial. Two candidates for mediating this actin-based process are the Arp2/3 complex and formin family proteins. In order...
Dartmouth Dissertations
Investigation of the molecular mechanisms of Erv26p-dependent protein sorting.
Carrier proteins -- Molecular aspects. Membrane proteins -- Physiological transport. Proteins -- Secretion. Biological transport -- Regulation. Saccharomyces cerevisiae -- Molecular aspects. Endoplasmic reticulum. Golgi apparatus. Vesicular...
Studies of the secretory pathway have revealed a multitude of secretory proteins that depend on the coat protein complex II (COPII) for export from the endoplasmic reticulum (ER) in transport vesicles. Some secretory proteins require protein...
Dartmouth Dissertations
Structural studies of dihydrofolate reductase-thymidylate synthase from Toxoplasma gondii and dynamin 1 from Rattus norvegicus.
Microbial enzymes -- Structure. Antiprotozoal agents -- Design. Toxoplasma gondii. Guanosine triphosphatase -- Structure. G proteins -- Structure. Thymidylate synthase-dihydrofolate reductase -- chemistry. Dynamins -- chemistry.
The first chapter of this thesis encompasses progress towards the X-ray structure determination and drug design for the dihydrofolate reductase-thymidylate synthase (DHFR-TS) enzyme from the protozoa Toxoplasma gondii, along with another mutant...
Dartmouth Dissertations
14-3-3 sigma modulates pancreatic cancer cell survival and invasiveness.
Pancreas -- Cancer -- Pathophysiology. Pancreatic duct -- Pathophysiology. Proteins -- Pathophysiology. 14-3-3 Proteins -- physiology. Pancreatic Neoplasms -- pathology.
14-3-3 is down-regulated in certain human cancers, but its expression is increased in pancreatic ductal adenocarcinoma (PDAC). The purpose of the present study was to investigate the potential role of 14-3-3σ in PDAC. The levels of 14-3-3...
Dartmouth Dissertations
Analysis of aberrant cell cycle regulation in pancreatic ductal adenocarcinoma uncovers novel thereapeutic approaches
Aberrant activation of cyclin D-Cdk4/6 is commonly found in pancreatic ductal adenocarcinoma (PDAC). Here, we show that PD-0332991, a highly specific inhibitor for Cdk4 and Cdk6, exerted growth inhibitory effects on human PDAC cell lines....
Dartmouth Dissertations
Understanding the vulnerabilities of tumors : a network-based approach to drug target discovery / by Nadia M. Penrod.
The demand for novel molecularly targeted drugs will continue to rise as we make progress toward personalizing cancer treatments to the molecular signatures of individual tumors. While the collection and analysis of genomic data has become routine,...
Dartmouth Dissertations
MicroRNA-10b promotes pancreatic cancer cell invasion by suppressing TIP30 and enhancing EGF and TGF-[beta] actions / by Haoxu Ouyang
MicroRNA-10b (miR-10b) is considered a marker of disease aggressiveness in pancreatic ductal adenocarcinoma (PDAC), in view of the fact that lower levels of miR-10b are associated with better response to neoadjuvant therapy, likelihood of surgical...
Dartmouth Dissertations
Estradiol regulation of innate immune protection in the human female reproductive tract / by Mickey Vinay Patel.
Estradiol is a key regulator of immune protection in the female reproductive tract (FRT). Its concentration varies during the menstrual cycle, leading to changes in innate immune protection. In this thesis, I demonstrate the multiple levels at...
Dartmouth Dissertations
Characterization of the interaction between Staphylococcus aureus and the cystic fibrosis cell line CFT-1.
Cystic fibrosis -- Immunological aspects. Cystic fibrosis -- Genetic aspects. Staphylococcus aureus infections -- Pathogenesis. Epithelial cells. Lungs -- Pathophysiology.
Patients with cystic fibrosis (CF) are susceptible to respiratory tract infections at an early age; with the most frequent initial isolate being the Gram-positive pathogen Staphylococcus aureus. Subsequently, these patients become chronically...
Dartmouth Dissertations
The SERM, Arzoxifene, and the rexinoid, LG100268, cooperate to prevent estrogen receptor-positive and -negative breast cancer as well as colon cancer.
Estrogen -- Receptors -- Regulation. Selective estrogen receptor modulators. Receptor-ligand complexes. Breast -- Cancer -- Chemoprevention. Colon (Anatomy) -- Cancer -- Chemoprevention.
We have previously shown that the selective estrogen receptor modulator, Arzoxifene (Arz), and the rexinoid, LG100268 (268) synergistically prevent breast cancer in an ER+ breast cancer model. This study was designed to determine the mechanism of...
Dartmouth Dissertations
Understanding PDZ affinity and selectivity: all residues considered / by Jeanine F. Amacher.
PDZ protein-protein interaction domains recognize short linear motif (SLiM) sequences typically at the extreme C-terminus of a target protein. These domains often act as scaffolds, connecting target proteins to additional interaction and catalytic...
Dartmouth Dissertations
Identification and characterization of signaling pathways underlying the tumorigenic activity of [Delta]Np63[alpha] in breast cancer stem cells / by Amanda Lynn Balboni.
Studies presented in this dissertation focus on the transcriptional targets and cellular functions of [Delta]Np63[alpha], the predominant TP63 isoform expressed in epithelial stem cell compartments. TP63, a member of the p53 family of...
Dartmouth Dissertations
Fusion proteins and select lipids cooperate as membrane receptors for the soluble snare Vam7p / by Vidya Karunakaran.
Yeast vacuole fusion involves three transmembrane SNAREs and a unique soluble SNARE, Vam7p. This SNARE cycles between vacuolar membrane-bound and cytosolic state. In its membrane-bound state, it is able to participate in vacuolar fusion by...
Dartmouth Dissertations
Constitutively activated PI3K signaling accelerates tumor initiation and progression in breast and lung cancers / by Mee Rie Sheen.
Phosphatidylinositol 3-kinase (PI3K) is a major positive regulator of the PI3K signaling pathway that regulates many important cellular functions including growth, proliferation, survival, metabolism, and angiogenesis. The PIK3CA gene, encoding the...
Dartmouth Dissertations
SGA screen identifies a cytoplasmic role for Dbp5/Rat8 and a novel player in nuclear pore complex biogenesis.
Nuclear membranes. Membrane proteins. Genetic regulation.
The coordination and coupling of the several steps in mRNA biogenesis helps to ensure proper regulation of gene expression. The DEAD-box helicase Dbp5/Rat8 is an essential mRNA export factor that has also been implicated in other steps of mRNA...
Dartmouth Dissertations
Targeting CFTR endocytic interactions as a therapeutic strategy in cystic fibrosis / by Lemira Sahar Al Ayyoubi.
Despite the recent FDA approval of the potentiator drug Kalydeco for treatment of cystic fibrosis (CF), only a small (3-5%) portion of patients benefit from this drug. Other functional classes of drugs including correctors are under clinical...
Dartmouth Dissertations
Novel techniques for the investigation of GPCR structure and function / by Joshua A. Weiner.
G protein coupled receptors (GPCRs) make up somewhere between 30-50% of all current drug targets, yet the structural characterization of these receptors has been moderate at best. Until recently, structural data were almost nonexistent and...
Dartmouth Dissertations
Runx1 is required in vascular endothelial cadherin expressing cells for hematopoietic stem cell emergence.
Transcription factors. Hematopoietic stem cells -- Genetic aspects. Hematopoiesis -- Regulation. DNA-binding proteins. Vascular endothelium.
Hematopoietic stem cells (HSCs) are the cells that can give rise to all different lineages of differentiated/mature blood cells. HSCs are capable of self-renewal and maintaining the homeostasis of differentiated cells for specific functions. The...
Dartmouth Dissertations
Molecular mechanisms underlying the induction of neuronal Na channel expression by growth factors.
Neurons -- Growth -- Effect of growth factors on. Cell differentiation -- Molecular aspects. Developmental neurobiology.
Dartmouth Dissertations
From target discovery to high-throughput screens--selective CAL PDZ inhibitors as candidate CF therapeutics
Peptides -- Therapeutic use. ; Chloride channels -- Pathophysiology. ; Ligands (Biochemistry) ; Protein-protein interactions. ; Cystic fibrosis -- Molecular aspects. ; High throughput screening (Drug development) ; PDZ Domains. ; Cystic Fibrosis...
PDZ domains are protein:protein interaction domains that serve as molecular scaffolds, especially in the case of specialized cellular environments like polarized airway epithelial cells of the human lung. Historically the domains have been thought...
Dartmouth Dissertations
Isolation and functional characterization of yeast vacuole snare complexes.
Membrane proteins -- Physiological transport. ; Plant proteins -- Physiological transport. ; Biological transport -- Regulation. ; Plant vacuoles. Saccharomyces cerevisiae -- Physiology.
Eukaryotic cells are compartmentalized into membrane-enclosed organelles. Genetic screens and reconstituted biochemical assays have revealed that intracellular protein trafficking is mediated by a conserved mechanism of vesicle budding, transport,...
Dartmouth Dissertations
Characterization of factors critical for initial stages of Vibrio cholerae intestinal colonization.
Vibrio cholerae -- Molecular genetics. ; Bacteria -- Adhesion. ; Virulence (Microbiology) -- Molecular aspects. ; Pili (Microbiology). ; DNA-binding proteins. ; Cholera -- Pathogenesis.
Vibrio cholerae is the etiologic agent of cholera in humans. Intestinal colonization occurs via ingestion of contaminated food and water and results in symptoms that include the production of the characteristic rice water stool, vomiting, and...
Dartmouth Dissertations
Conservation and evolution of DNA regulatory signal patterns
Dartmouth Dissertations
Inf2-formin that polymerizes and depolymerizes actin on endoplasmic reticulum.
Actin. Microfilament proteins. Polymerization. Endoplasmic reticulum.
Dartmouth Dissertations
The effects of endocrine disruptors on the development of Xenopus embryos.
Xenopus laevis -- Embryology. Xenopus laevis -- Endocrinology. ; Estrogen -- Physiological effect. ; Estrogen -- Toxicology. ; Nonylphenol -- Physiological effect. Endocrine toxicology.
Many environmental toxicants found in pesticides, herbicides, and industrial solvents are believed to have deleterious effects on development by disrupting hormone-sensitive processes. Xenopus embryos were exposed to commonly encountered endocrine...
Dartmouth Dissertations
A complex of the BCL2-like protein CED-9 and the BH3-only protein EGL-1 recruits DRP-1 to mitochondria and promotes mitochondrial fission
Mitochondria -- Physiology.; Fission (Biology) ; Guanosine triphosphatase. ; Caenorhabditis elegans. ; Caenorhabditis elegans Proteins -- physiology. ; GTP Phosphohydrolases -- physiology. ; bcl2-Associated Death Protein -- physiology.
Dartmouth Dissertations
Neuronal interferon signaling : implications for HSV-1 replication and pathogenesis / by Pamela Rosato
Herpes simplex virus-1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG) wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of...
Dartmouth Dissertations
Kinetochore influence on mitotic spindle structure.
Spindle (Cell division). Microtubules. Mitosis. Kinetochores -- physiology. Microtubule-Associated Proteins -- physiology.
Proper chromosome alignment and segregation depends on the formation and maintenance of a bipolar mitotic spindle with focused poles. It has been shown that microtubules are focused at spindle poles through the combined actions of centrosomes and a...
Dartmouth Dissertations
Detecting, characterizing and interpreting Gene-Gene interactions associated with metabolic traits / Rishika De
The ubiquitous complexity of common diseases is one of the biggest challenges facing the field of personalized treatments and precision medicine. This complexity can be attributed to various sources such as the genetic make-up of an individual,...
Dartmouth Dissertations
Targeting anaphase catastrophe through CDK inhibition in lung cancer / by Shanhu Hu
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Pharmacological targeting of aneuploidy is an attractive therapeutic strategy, as this would preferentially eliminate malignant over normal cells. Our prior...
Dartmouth Dissertations
Understanding the role of Toxoplasma gondii secreted rhoptry (ROP) and dense granule (GRA) effector proteins in host-parasite biology using reverse genetics / by Leah M. Rommereim
Toxoplasma gondii is an obligate intracellular pathogen that is able to survive in a range of hosts due to its repertoire of secreted effector proteins. Utilizing the type I and type II Δku80 strains we engineered a collection of targeted knockout...
Dartmouth Dissertations
Identification of signaling pathways coordinating cell growth and division in fission yeast / by Lin Deng
Cell growth and division are coordinated to keep homeostasis of cell size. The components of the core machinery are conserved in a wide range of cell types. Fission yeast (S. pombe) has been an important model organism to study cell size control...
Dartmouth Dissertations
Eisosomes organize the plasma membrane of yeast / by Ruth V. Kabeche
The cortical cytoskeleton mediates a range of cellular activities such as endocytosis, cell motility, and the maintenance of cell rigidity. In yeast cells, prominent cortical structures called eisosomes generate specialized domains termed MCCs to...
Dartmouth Dissertations
A proteomics approach to NIMA-related kinase signaling in mitosis / by Sierra N. Cullati
NIMA-related kinases (Neks) control several aspects of cell division downstream of master mitotic regulators such as Cdk1 and Plk1. Though depletion of Nek6, Nek7, or Nek9 results in cytokinesis failure, to date no molecular mechanism has been...
Dartmouth Dissertations
Biological significance of VIVID photocycle length and the control of gene expression by the Neurospora clock / by Arko Dasgupta
Sensing light from the environment using photoreceptors is of great adaptive significance to eukaryotes. A prominent feature of the photochemistry of these receptors is the photocycle length, the time taken to decay from the initial signaling light...
Dartmouth Dissertations
Investigation of ER-Golgi membrane proteins influencing COPII tethering and fusion / by Indrani Mukherjee
Protein secretion is executed by the secretory pathway, which involves the delivery of membrane and soluble secretory proteins in vesicle intermediates that capture newly-synthesized proteins assembled in the endoplasmic reticulum (ER) and then...
Dartmouth Dissertations
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Correspondence of Commodore Oliver Hazard Perry
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Hot Apple Cider Tea Bags
Let the aroma of fresh apple and mulled cider spices envelop you as you sip this golden infusion. The crisp, lingering finish will leave you wanting more!
As featured in Ok! Magazine's A-List Trends.
A naturally-caffeine free blend of apples, cinnamon cloves and ginger. Reminiscent of apple cider, with the luscious aroma of cinnamon and cloves, make this cup the perfect accompaniment to the colors of the harvest season.
This herbal blend is naturally caffeine-free. More about caffeine.
Steeping Instructions
Steeping herbal tea is easy. Simply heat fresh, filtered water to a rolling boil. Then pour water over tea and steep for 5-7 minutes if using a tea bag or full-leaf.
Apple pieces, cinnamon, orange peel, rose hips, berry leaves, natural apple flavor, ginger root, cloves, natural lemon flavor, citric acid and cardamom seeds
Country of Origin
Citizen Reviews
The Hot Apple Cider tea is yummy. The flavor is great on its own, with sugar, with faux sugar, or with Vanilla Cream . My non-tea-drinking husband has asked for a cup of Hot Apple Cider Tea several times.
The cider smells super. I made it with a small amount of water not even a full cup. Left the bag in extra long. Taste is so weak it is barely there. Kind of disappointed.
This is my new favorite tea. I love the cinnamon and apple flavor I add a bit of cream and it is like a hug for my taste buds. I highly recommend it.
I absolutely love this tea. It feels like true hot apple cider without the calories or guilt. I also love that it's caffeine free!
This tea tastes like the honest to goodness hot apple cider I love to have without the added sugar of having the juice. The spices and overall flavor of this tea make me want to have one cup after the other. I enjoy this tea so much I refuse to share it the 5 other members of my family who ALL love tea.

subset: commoncrawl


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Foreign exchange reserves excluding gold reached 0.695 USD bil in 2017 in Dem. Republic of the Congo, according to the National Statistical Office. This is 1.80 % less than in the previous year.
Historically, foreign exchange reserves excluding gold in Dem. Republic of the Congo reached an all time high of 1.68 USD bil in 2013 and an all time low of 0.011 USD bil in 1961. When compared to Dem. Republic of the Congo's main peers, foreign exchange reserves excluding gold in Angola amounted to 17.5 USD bil, 0.363 USD bil in Central African Republic, 0.380 USD bil in Congo and 2.08 USD bil in Zambia in 2017.
Dem. Republic of the Congo has been ranked 128th within the group of 151 countries we follow in terms of foreign exchange reserves excluding gold, 25 places above the position seen 10 years ago.
FX reserves in a strict sense are "only" the foreign currency deposits and bonds held by central banks and monetary authorities.
Buy Foreign Exchange Reserves, Excluding Gold (USD) data for Dem. Republic of the Congo.
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Welcome to the M+NetMail Wiki!!
As already mentioned on the wiki main page, please feel free to join in. You can read anything in here without logging in, but if you feel like commenting on something, or starting a new topic, you'll need to use a Novell Login account (which you'll be prompted to create if you don't already have one). If you are unfamiliar with using Wiki's in general, please visit Novell Wiki or the grandaddy wiki info site www.wiki.org for some background info.
What is it?
M+NetMail is a E-mail and calendaring system that can handle 2 to 2,000,000 users.
NetMail's components run on a variety of OS platforms, including Linux, NetWare and Windows.
M+NetMail can be used in a wide variety of deployment scenarios. Its scalability, stability and enhanced feature set appeals to both onsite and hosted service deployments in education, business, government and financial services. Designed to fit any size environment, from 2 to 2,000,000+ users in a single deployment, M+NetMail is capable of processing millions of email messages a day on low-end hardware without delivery failures or errors.


text: nerdnado Posted in N Best definition nerdnado A nerdnado is when something nerdy spreads like a class 5 tornado across the internet world. When digg pulled the story abort the AACS key off the main page, the number spread like a nerdnado. How satisfied are you with the definition? Looking for nerdnado meaning? Delighted that you discovered the greatest determine on our web site! Recently this definition was actually observed 31 times.


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Like!! I blog frequently and I really thank you for your content. The article has truly peaked my interest.
Phone application development is crowning the world, ever since the release of iPhone and increasing number of iPhone users every day. With the increasing demand for iPhone applications, application developers are polishing their skills in order to provide best services to end users.
However, the process is not as easy as it may sound. Several mistakes are ought to happen by mobile app development services Oregon or elsewhere, which results in disaster.
Below highlighted mistakes are few common ones that need to be avoided-Mistake 1- Improper planning
A major loophole behind the downfall of an app is improper planning. Hence, right away starting with the development of the app, it is important to make a proper plan that will fulfill the purpose of application development.Mistake 2- Drop the idea of introducing a lot of plugins and tools
This is one of the common mistakes, which mobile app developers Oregon tend to make. In order to develop a better app, developers often use a lot of plugins and tools, which makes the application complex. It is advisable to keep the app simple yet attractive.Mistake 3- Do does not use extra high resolution
The success of the mobile application is judged based on the user interface. With better user experience, developers tend to develop the extra high-resolution user interface. This, in turn, does nothing good instead slows down the app and making the viewer frustrated. Hence, poor applications make users turn to competitors. Thus, resolution of the app should be appropriate.Mistake 4- Refrain scrolling design
Too much for scrolling is never liked by users. Thus, an app should not have much of scrolling that annoys the end user and forces him to look for some other app.Mistake 5- Missing out monetization factor
Expecting a site to make business as soon as it is built is the biggest misconception. Developing the app and monetize the app is necessary for doing right advertisement amongst the targeted audience.Mistake 6- A big no to multitasking app
Last but not the least, the mistake of making an app multitasking should be avoided. The development of app should concentrate on a single factor, instead of adding too many traits in a single app. For example, integrating gaming into the business app is a wrong development decision.
Word of wisdom – After reading the aforementioned mistakes, you must have got an idea what things are to be avoided while developing iPhone app. Hire the mobile app development services professionals in Oregon is viable decision to make as they know what is best for your business.
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We have the answer, and we're not limited to the best marketing insights and practices. We're ready to talk coffee (over coffee), discuss Dr. Dre and Dr. Seuss, and tackle your biggest questions. Think you can stump us? Ask away.
Address: 2231 S. Barrington Ave, Los Angeles, CA 90064
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© 2019 Hawke Media. All rights reserved.
© 2019 | All rights reserved Hawke Media.


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Meet Tamika Sykes?Mik to her friends (if she had any). She?s hearing impaired and way too smart for her West Bronx high school. She copes by reading lips and selling homework answers, and looks forward to the time each day when she can be alone in her room drawing. She?s a tough girl who never gets close to anyone, until she meets Fatima, a teenage refugee who sells newspapers on Mik?s block. Both Mik and Fatima unite in their efforts to befriend Jimmi, a homeless vet who is shunned by the rest of the community. The events that follow when these three outcasts converge will break open their close-knit community and change the lives of those living in the Orange Houses in explosive and unexpected ways.
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Guys, Just back from one round trip Bangalore -Trichur -Bangalore.
I chose to drive via mysore -gudallur - vazhikkadavu - nilambur - kalikkavu - karuvarakkundu - mellattur -perinthalmanna -pattambi - shournur - Thrissur. and I lost my way after vazhikkadavu and ended up back in the calicut route, travelling almost 80 -100 KM's more and 3 hrs extra. I didn't realize that I lost my way as I was busy talking..
I was totally ****ed off with myself... .. I started from bangalore 4:30 am and reached Trichur 5 PM where I was targeting to reach by 12 - 1 Pm.
On the way back I took CBE - salem - Bangalore route. I started 8:50 am from Trichur, and managed to do only 159 Km's in the busy roads till some where near Avinashi at 12:15 . Being a Working day, the rodas were pretty empty after this streatch...and I reached home (ITPL) by 4:35. I was happy to get clear roads and on the stretch, I managed to 170KM/hr today. ( For few minutes, on a straight stretch ).Bangalore welcomed me back with good Rain....


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- Tracy Whiteside
Before and After
This courageous woman had her photo session last week. She is a mom, sister, aunt, friend, baker, fashionista. She is strong, resilient, compassionate, kind. We wanted the outside to match the inside. We all love a good transformation. A great makeover can build your confidence and give you a more positive outlook. It can help you through tough times. Look at her now...
#portraits #makeovers #women #beautyportraits #PhotographyPhotographerProfessionalphotograph #fashion


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Little Souls Cause
My name is Mike Hourel and I am 30 years old. I will be riding the 947 cycle challenge in honor of not only my little princess Robyn Houreld 23-01-2016 to 31-01-2016, but for many other premature little babies still fighting out there who think they have been forgotten.
To contribute, please select the project below and then the donate button next to the barometer....
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Content Type: Gaming Reviews
Date: October 8, 2018
Jack N' Jill DX is a side-scrolling platformer available for download from the PlayStation Store for the PS4 and PS Vita. Jack N' Jill DX was originally created by Rohan Narang before Ratalaika Games developed and published a port to Vita, PS4 and more platforms besides. Can Jack N' Jill DX deliver a fresh take on the side-scrolling platformer?
The story is essentially the entire premise of gameplay as it revolves around one of two characters named Jack and Jill who are friends getting lost and Jack or Jill having to find their friend at the end of every level.
Gameplay begins with only one level available to select and play as the next level has to be unlocked by completing the current level. Every level has anywhere from 1 to dozens of coins to collect that are utilised to unlock mini-games after completing a world to unlock the option of purchasing the mini-game. Each mini-game has its own objective such as the first mini-game that requires the player to help as many baddies across the pit before time runs out in order to earn tickets in exchange for unlocking new items at the shop. There are also numerous challenges in the form of additional objectives including collecting 1,000, 2,500 and 5,000 coins respectively; defeating 10, 100 and 500 enemies by stomping on them; finishing 20 levels as Jack and Jill; completing each world; and more besides.
Character design involves the player being able to choose from two charming playable characters named Jack and Jill. Enemy design includes multiple shapes and sizes of spikes and baddies that are positioned throughout the majority of levels. Both playable characters gain new abilities as the player progresses through a certain quantity of levels and within each world. For instance, within the first world either character can jump on an enemy's head to squash it, but jumping immediately after landing on the enemy's head provides an extra jumping surface to avoid nearby spikes and enemies, while upon reaching world 2; either character can wall jump in order to reach higher platforms. Characters can be customised by purchasing items from the in-game shop such as a variety of hats from a beanie to a mohawk for 25 tickets each or becoming a cat or bear for 50 tickets each, while your character can also wear an umbrella or become a cake for 100 tickets each and much more besides.
Environment design introduces many differing lengths of jumps, bouncing on springs, hazards and enemies over the course of 140 levels spread throughout 7 worlds with 20 levels per world, while the unlockable mirror mode flips the platforms within the levels around in addition to the background environments.
Jack N' Jill DX supports cross-buy between the PS4 and Vita, although it unfortunately does not support cross-save, so you will not be able to continue from your previous progression on the Vita version when playing the PS4 version and vice versa. Cross-buy presents a superb amount of value as it means that you will be purchasing the PS4 and Vita versions of the game with just a single purchase.
The controls are quite simplistic on Vita and the DualShock 4 controller as the player only needs to press X to jump over spikes and onto or over enemies as the player does not need to move the chosen playable character as the character moves by him or herself. The Vita's control scheme does not utilise the touch screen, while the DualShock 4 controller does not support the touch pad, alongside no light bar support that could have produced green when completing a level or red for when being defeated by an enemy or hazard and there is no vibration that could have occurred when being defeated by an enemy or hazard.
Graphically, Jack N' Jill DX has a nostalgic retro aesthetic from side-scrolling platformers of yesteryear for characters, enemies and foreground and background environments. In an excellent design choice that is reminiscent to that of enhanced colour palette options for Game Boy games presented on Game Boy Colour; Jack N' Jill DX allows the player to purchase a purple, beige, pink, green, red, blue or orange screen colour to replace the original greyscale screen colour for 100 tickets per screen colour from the in-game shop that essentially changes up the graphical display.
Jack N' Jill DX's presentation is solid with a great user interface across various menus such as the main menu, level and world selection menus, mini-games menus, challenges menu, options menu and gameplay menus with support for navigation via the left analogue stick, directional pad and face buttons on Vita and DualShock 4, although it does not include support for navigation via the right analogue stick and touch screen or touch pad between Vita and DualShock 4. Menu backgrounds include a panning camera displaying the environments from the side-scrolling perspective.
Sound effects include your chosen playable character collecting coins, jumping, wall jumping, bouncing on a spring and being defeated by an enemy, spike or not making a jump; accompanied by charming retro platformer inspired music. There is no DualShock 4 speaker implementation that could have produced certain or all sound effects or music.
The trophy list includes 12 trophies with 0 bronze trophies, 0 silver trophies, 11 gold trophies and 1 platinum trophy. The first 3 gold trophies will be achieved within 10 seconds of gameplay including the I Found You gold trophy for finding Jack or Jill; the You Need to Start Somewhere gold trophy for completing a level; and the I'm A Poor Peasant gold trophy for getting a coin. Further trophies include the It's Minigame Time gold trophy for unlocking a mini-game and the This is Bouncy gold trophy for bouncing by squashing an enemy. Better yet, the PS4 and Vita have individual trophy lists resulting in the potential of having 22 gold trophies and 2 platinum trophies within around 45 minutes to an hour in total.
There are no difficulty levels, although despite having a very simplistic control scheme; the difficulty curve is gradually increased by progressively introducing new gameplay elements such as hazards, enemies, jumping on enemies, wall jumps and more besides. Even the mini-games have a balanced difficulty by changing the positioning of platforms from one attempt to another.
There is understandably no local or online multiplayer; although it would have elevated the gameplay by having online leaderboards displaying the fastest times for completing each level, each world and every world combined.
Jack N' Jill DX's replayability stems from 140 levels spread throughout 7 worlds, unlockable mirror mode that flips the levels around to effectively double the quantity of levels, 7 unlockable mini-games that provide tickets to purchase unlockable items and options from the in-game shop including character customisation and Game Boy Colour stylised colour palettes, 26 objective based challenges and 2 playable characters that will collectively have players returning for many hours.
- Title: Jack N' Jill DX
- Developer: Rohan Narang (Original Developer)/Ratalaika Games (PS4/Vita Port)
- Publisher: Ratalaika Games
- System: PS4/PS Vita
- Format: PSN Download
- Cross-Buy: Yes
- Cross-Play: No
- Players: 1
- PS4 Hard Drive Space Required: 52.45MB
- PS Vita Memory Card Space Required: 49MB


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Quakers drop Potters
SALEM–The Salem volleyball team defeated East Liverpool 22-25, 25-14, 25-20, 25-23 in the Kent State Columbiana County Classic Monday at Cabas Gymnasium.
The Quakers are now 15-5 overall.
Elly Exline powered Salem with 22 kills, two blocks and 20 digs, while Hayden Carner added 12 kills and four blocks.
Also for the Quakers, Jaden Hamilton had 11 kills and three blocks. Jenna McClish led the defense with 17 digs. Kaylee Freeman handed out 38 assists and also accounted for six aces.
The Quakers won the jv match in three sets. Alivia Davidson led the way with five aces.
The Salem freshman team won in straight sets. Kylie Skinner led the Quakers with 13 digs.
The Quakers return to Eastern Buckeye Conference play tonight at Canton South.
Heartland 3,
Lowellville 0
COLUMBIANA–The Heartland Christian volleyball team kept rolling with a 25-21, 25-20, 25-16 win over Lowellville Monday.
The Lions are now 18-3 overall.
Emma Hall had 20 kills and 14 digs for Heartland. Lydia Wilson added seven points, four aces and 30 assists. Dara Arthurs had seven kills, 15 points, five aces and seven digs.
Lowellvile swept the jv match. Amelia Banner had five kills for the Lions. Jorden Webb had five points and two kills.
Mineral Ridge 3, Columbiana 1
COLUMBIANA–Mineral Ridge defeated Columbiana 25-14, 15-25, 25-19, 25-14 in volleyball action Monday.
The Rams, who are the top seed in the upcoming Div. IV Columbiana district tournament, improve to 19-1. Columbiana falls to 10-12.
For the Clippers, Marissa Makosky had five kills, seven assists, two aces and eight points. Tori Long added five kills and eight digs, while Julia Rapp had three kills and two blocks.
Also for Columbiana, Grace Witmer had two kills, 11 assists and seven points. Madison Moser had two kills, two blocks and five points.
Mineral Ridge won the jv match 25-22, 25-21.
Tomi Ross had seven points, two kills and three aces for the Clippers. Addie Zohnd had three kills and a block.
Columbiana hosts Campbell in Div. III sectional action next Tuesday.


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Sharm El-Sheikh features 4 diveable wrecks positioned fairly nearby. Some of these are the Agia Vavara Walt Frazier Jersey , Dunraven, Million Hope and Zingara. The Million Hope is one of the greatest wrecks ever to have been lost to the Red Sea. The wreck is found on top of the hull of the Hey Daroma. A part from her bows, not much can be observed of this scaled-down vessel. The Million Hope bears 4 large cranes. One of these has separated itself and at this moment rests on the seabed. A range of schooling fish have taken up home in the ship鈥檚 shell. The timid guitar fish has been seen amongst them.
Hurghada is a well-known point to access the submerged secrets of the Abu Nuhas reef. Diving holidays here will see you tour the Kimon M Anthony Mason Jersey , Chrisoula K, Ghiannis D and Carnactic. Chrisoula K is a superb dive for those who wish to penetrate a vessel. Those who venture deep enough to access the engine rooms demand to be mindful. Presently there are a quantity of obstacles in this location. Frustration can occur while orientating on your own here due to the crafts position. It is resting on it's port or starboard. The Rosalie Moller is one more popular dive in this area. At a depth of 50 metres it is reserved for knowledgeable divers only. Enriched air flow diving courses are available for people who want to extend their abilities set and investigate these absolute depths.
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Why do cardiac arrests happen in the bathroom? Health Articles | November 7, 2019
People tend to ignore about their lives ,Especially when it comes about cardiac article show about聽why do cardiac arrests happen in the bathroom John Starks Jersey , and how to take care of yourself from it.
Cardiac arrest is one of the most common death cause nowadays.
It has only a 10.6% average survival rate. In the United States, approximately 395,000 cases of cardiac arrests take place out of the hospitals every year.
Many time we get to hear that someone got cardiac arrest in the bathroom. Here Frank Ntilikina Jersey , we will discuss the cause of cardiac arrests happen in the bathroom. To maintain your heart health you can consult with any cardiologist in Chennai.
What is a cardiac arrest?
If the heart starts malfunctioning and stops beating unexpectedly, that is called cardiac arrest. In this situation, the heart fails to pump the blood to the other parts of the body as well as the brain. The heart muscles are failed to contract and expand so the blood can not flow. If the heat flow to the heart is blocked due to any blockage on the artery heart attack takes place. As a result of the heart attack Courtney Lee Jersey , cardiac arrest may happen just after a heart attack. So heart attack and cardiac arrest are connected.
Why do cardiac arrests happen in the bathroom?
It is found that cardiac arrest has occurred in the bathroom very often. Which is not a coincidence, but there is some scientific cause behind it. Here we will discuss some of them.
Abrupt changes in Blood pressure
Talking bath in the morning is a risk factor for people with high blood pressure. To avoid cardiac arrests, the temperature of the water and environment should be on the count.
Sudden exposure to cold water cause sympathetic impulse Allan Houston Jersey , which causes a rapid fall in the temperature of our skin and also leads to high blood pressure. This abrupt changes in blood pressure reduce the blood flow to the heart as a result of this the heart failed to get enough oxygen. This may cause a cardiac arrest and heart attack in the bathroom.
Toilet Strain
The wrong posture of sitting for waste elimination is another reason for cardiac arrests in the bathroom. In seating position repeated and intense Valsalva Maneuvers is needed in order to empty the bowels. This excessive strain majorly affects the cardiovascular system causing insufficient blood flow in the heart. It leads to cardiac arrests. Squatting position is always better than sitting position as it requires less strain.
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Today(January 10th), the black line maintains a rising trend, but the overall increase is not large, and it basically fluctuates around the 3500 yuan. External news sources, as the US-Iraq conflict has been digested, in addition, the US Congress is expected to vote this week to limit Trump's war power, the market mentality has eased. The increase in the mainstream futures of thread futures is significantly larger than the increase.
The spot market price consolidates in a narrow range, the thread price is slightly loose, other varieties basically remain sideways, the mainstream of the transaction is light, there are winter storage requirements in some regions, and speculative demand in most regions is more cautious. At present, the demand from the terminal has gradually weakened, and this week there will be a succession of steel traders and terminal construction companies starting to take holidays.
It is reported that the southern part of the convoy will be closed on the 10th, and long-distance transportation will be stopped. Short-distance and unloading will not be affected temporarily. The first snowfall of the new year has not completely melted, and the nationwide large-scale rain and snow weather will come again. The increasingly weak market will be lighter, and transportation will also be affected.
From the current point of view, no matter the winter storage or the terminal market before the holiday, particularly large actions may no longer appear.
In terms of prices, according to monitoring data, today, the average price of Ф25mm three-level rebar in key domestic cities is 3791 yuan (ton price, the same below), down 4 yuan from yesterday; the average price of Ф6.5mm high-line in key domestic cities is 4034 yuan, It is 1 yuan higher than yesterday; the average price of 5.5mm hot rolled coil in key domestic cities is 3838 yuan, which is the same as yesterday; the average price of 1.0mm cold plate in key domestic cities is 4382 yuan, which is 2 yuan lower than yesterday; 20mm in key domestic cities The average price of the middle board was 3,795 yuan, up 1 yuan from yesterday.
In terms of raw materials, today, Q235 carbon steel billet 150 * 150 in Changli, Tangshan area was 3,310 yuan, up 10 yuan from yesterday; the price of 61.5% grade PB iron ore in Jingtang Port was 695 yuan, down 10 yuan from yesterday; Grade metallurgical coke including tax to the factory price of 1960 yuan, unchanged from yesterday. (source from zh818.com)
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Vice President Mike Pence has made his second stop in West Virginia in the past three months to campaign for Republican U.S. Senate nominee Patrick Morrisey. This time, he also urged residents to vote in the upcoming election.
Pence and Morrisey attended Saturday night's rally in Bridgeport. Morrisey, who is West Virginia's attorney general, faces Democratic incumbent Sen. Joe Manchin on Nov. 6.
Pence and Morrisey reminded the audience that the state's early voting period starts Oct. 24. Morrisey says "this is going to be a close election. I need your help to get over the edge."
In the 2014 midterm election, just 37.4 percent of registered voters cast ballots – the lowest for a regular general election since the secretary of state's office started keeping such records in 1950.


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Our Gothic and Graveyard Wedding packages aren't just for Halloween anymore! In fact, couples who choose to marry a little on the darker side believe every night is perfect for sacred rites. News flash: We now offer a vampire wedding Cirque style! (Enter flying vampires? YES!) Say "Til death do us part," amidst a cemetery clad in thick fog. Candles light the chapel and strains of organ music echo. Dracula or The Grim Reaper will serve to exchange your vows. What could be eerier for YOUR wedding night?
How about that vampire wedding Cirque style? Our "When Vampires Fly" package literally adds another level of fear. For this wedding, you'll get a live performance by two acrobatic vampires! The sublime sensuality will give you goosebumps. Here are all the haunting details: https://www.vivalasvegasweddings.com/las-vegas-wedding-packages/themed-weddings/when-vampires-fly-wedding
We guarantee that your vampire wedding Cirque style will astound your guests! After all, who'll be expecting flying vampires? Or a Dracula minister? Share the general theme, though. That way, friends and family can dress in blacks and blood reds. Makes for incredible wedding pics!
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When writing content, like with any other piece of information to be written, the biggest part is having a good understanding of how you should write. Each country has its own writing guides, and Australia isn't different. The Australian government has released a style guide for writing online, which can be read here.
Of course, writing is about more than just having a well-structured post. The content needs to be engaging and perform well. Your content needs to be visible to the website visitors, and to people searching for your content on Google and Social Media.
It is important to write in your own brand voice, if you haven't investigated a brand voice before, we have a detailed blog on brand voices here. A brand voice, or a style guide, is the way that a brand positions itself. It includes:
- Grammar
- Tone
- Logo usage
- Colours
- Visuals
- Points of view
All these factors into how a customer perceives your brand. The customer expects an authentic voice, and not a copy of another business. By having a good brand style guide people know what to expect from your brand. This is why businesses such as Apple, Coca-Cola and banks do so well.
Businesses with a proper style guide know how to write and what to write. They understand what they need to do to make their customers engage.
A style guide should be more than just a company looking inward. A company needs to look at their customers and what the customers want. By researching what customers enjoy and want to engage with you can tailor your content.
Writing content that people love
When writing content, it is important to make sure that the author takes the time to check the content. Very rarely does a content writer get their copy perfect in one go. By reviewing your copy, you will pick up on errors and mistakes. Below are a few tips on how to make sure your content has the highest chance of success:
- Wait one day between your first and second draft
- Read through the content first and highlight what can be improved
- Start making changes in a broad scale, look at your highlights and update what you think needs changing
- Let the text rest for a bit again and go through it in more detail, make any changes as required. Make sure that you are getting to the point.
- Spend a good amount of time working on the title. A good title will grab attention.
- Make your first paragraph stand out. You need to grab the reader's attention with the first paragraph, or else you will lose them.


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Changes in consumer behaviour, technology adoption and creative payments offering are driving a transformation of the payments ecosystem, with the result being that the demands of banks and processing hubs have outgrown their technological capabilities.
Between 10 and 15 years ago we saw significant investment in the payments industry following concentration and internationalisation of both bank groups and processors. Mainframe technology which was the peak of advancement at the time – a position it maintained for decades – offered stability. However the downside of these dedicated platforms was inflexibility, which is becoming increasingly problematic for banks when time-to-market provides such a competitive edge.
Operating dedicated platforms for any type of card does not integrate well with an important aspect of the modern retail banking business: the single-customer-view. Today's customers are impatient and unlikely to wait for a bank agent to fiddle with a number of systems in order to view the balance history. Any workaround that provides halfway unsatisfactory results would require significant IT effort to build interfaces in the bank's front and back office.
There is consensus across the industry that it is time for a new generation of platforms, either through the development of a proprietary system or collaboration with a payments processor, such as SIX.
The decision to move to a new platform is not an easy one as it requires significant investment, in terms of both money and time. The migration process is likely to tie up resources for at least a year in the business and IT departments alike. Of course, once successfully implemented, a new platform will result in a considerable return on investment (ROI). Business processes and transaction processing will be simplified and, more importantly a competitive edge will be added when compared with that of peers, in particular, greater flexibility which makes it easier for issuers to add new customers, features and products.
In practice, this has led to a move away from mainframe systems to cluster technologies when it comes to systems architecture. One of the key strengths of the new generation platforms is the database which can be accessed from a variety of applications. As the data models are at the centre of the architecture, the surrounding systems can perform the required transactions at unprecedented speed. Consequently, new products can be developed and implemented easily and quickly: it's more of a configuration than having to code or programme the logic. Subject to complexity, products can be ready to market in weeks instead of months.
Like any technical migration the move from traditional cards business to 360° solutions is a huge project for IT support, but the benefits are tangible. The capabilities of a new platform allows products to be brought to market with greater ease and speed and allows forward-thinking banks to maintain their position at the vanguard of technological developments and market needs. Perhaps most important is the reduction in total cost of ownership in operations and maintenance that modern platforms provide.
In terms of product diversity, new generation platforms can handle the whole bandwidth of card products and virtual cards, with two distinct advantages. First is the commercial aspect of a broad and innovative product portfolio. Through integrated processing of debit, credit and prepaid cards as well as newer solutions like contactless, mobile and P2P, an issuer can bundle all volume and leverage the economies of scale stemming from its entire portfolio.
Second is risk management and customer aspect as the system provides a comprehensive view of the customer with a single click – something which allows banks to better assess risk and ensure compliance with Basel regulations.
Increased flexibility means that banks can make a stronger, faster impact on the market, giving them a much sought after edge over their competitors. Differentiators such as peer-to-peer solutions are becoming ever more important as customers look for speed, security and convenience. Paymit is one of the most recent examples. It is a mobile-based application that SIX has developed for and with the Swiss banking community aiming at displacing cash transactions.
Regardless of the technology that sits behind the processing services, the expertise of the payments processing partner and its customer focus is paramount. Our research shows that the majority of SIX customers are interested in what we refer to as full outsourcing model – levels ranging from pure processing through comprehensive technological provision to a full service capability where the processor takes over the full spectrum of card operations for a financial institution, encompassing authorisation, clearing and settlement, fraud and claims management and also call centre services.
Customers place ever more expectations on their bank and are increasingly vocal when these expectations are not met. At the same time, interchange regulations put issuer profitability under significant pressure. A technology partner can support its banking customers to find the right strategy and manoeuvre among the multiple future payment options. Banks need to take the bull by the horns and be prepared for sweeping shifts.
By Andrej Eichler, Head of Financial Industry Services, SIX Payment Services.


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|Main Page
- "Diesel engines to the rescue!"
- ―Paxton
The Big Freeze is the fourteenth episode of the twenty-first series.
It is after Christmas on Sodor, and everyone is enjoying the snowfall, but it causes delays on some deliveries, such as Paxton returning to the Vicarstown Dieselworks with fresh diesel fuel for Den and Dart. Meanwhile, Diesel has some fun bumping Thomas out from under the coal hopper before he can fill up, though Percy warns Thomas that the hopper is nearly empty. Thomas knows a fresh shipment is due any day.
That night, the Fat Controller and Bertie nearly collide with each other on the icy roads after giving each other a friendly honk. As a result, the next morning, the Fat Controller visits the sheds to advise the Steam Team to be extra careful on the rails, administring speed restrictions and reduced services, especially having Gordon be assigned a back engine for Gordon's Hill.
His concerns are proven correct when Emily, after having her snowplough removed, and her coaches nearly collide with Toby and Henrietta due to frozen signals and points, leading to the signalman fainting in relief after seeing Emily and Toby almost colliding with each other. Henry derails on a siding due to frozen points, and James overshoots the platform at Knapford Station due to icy rails. By that evening, the Fat Controller is impressed by the Steam Team managing to keep things running and being Really Useful, but Percy is still worried about the coal delivery. Without it, the steam engines will be out of action until it arrives. The Fat Controller hopes it will be arrive by morning from the Mainland and tells the engines to keep their hopes up.
However, the next morning, Emily finds the hopper empty, as the coal is still late. As a result, the Fat Controller has ordered the Steam Team back to Tidmouth Sheds until further notice. Thomas, despite Annie and Clarabel telling him to listen to Percy, wants to finish taking his passengers to their stations. Unfortunately, he runs out of coal and has to stop to let his passengers disembark at Kellstorpe Road Station, stranded. As he and his coaches worry about how the Fat Controller will keep the railway running with the Steam Team out of action due to the coal shortage, Thomas' spirits are lifted when he hears the horns of the diesels and sees them coming up the tracks, but they past right through the station without stopping to help Thomas, his coaches or his passengers, leaving them disheartened.
Den, Dart and Sidney soon return with the Express coaches to pick up Thomas' passengers, while the other diesels work to keep the railway running. The rest of the Steam Team make it back to Tidmouth Sheds safely on their remaining coal with Gordon being the last of them. Percy is worried about Thomas, who remains stuck at Kellstorpe Road Station with Annie and Clarabel, freezing in the winter night air. Diesel passes by but refuses to help Thomas and his coaches, still smug at having more important things to do and being Really Useful.
The next day, it is still freezing out. Annie and Clarabel try to keep their spirits up by singing Christmas carols, and soon they and Thomas hear Diesel again, but believe that he is just going to leave them to suffer more until he reveals he came with the coal trucks to get the Steam Team back in action. Annie and Clarabel call Diesel their hero, and he is touched by this, while Thomas feels insulted after hearing that.
Thomas returns to the coal hopper, where the rest of the Steam Team are lined up to be reloaded with fresh coal, and Percy is relieved to see him after being so worried about him. With fresh coal, the Steam Team return to work, and the next day, things seem to be getting better as the big freeze has ended and things are starting to warm up around the Island. As Thomas passes by Diesel, he whistles to him, but as Diesel honks back with a huge discharge of fumes, upset at no longer being important with the Steam Team back to work, he hears Annie and Clarabel still praising him for his heroism with saving them. He then blushes and smiles before continuing on his way.
- Thomas
- Edward
- Henry
- Gordon
- James
- Percy
- Toby
- Emily
- Diesel
- Den
- Dart
- Sidney
- Paxton
- Annie and Clarabel
- Bertie
- Sir Topham Hatt
- A Signalman
- Daisy (cameo)
- 'Arry and Bert (cameo)
- Salty (cameo)
- Norman (cameo)
- Philip (cameo)
- Henrietta (cameo)
- Cranky (cameo)
- The Bird Watcher (cameo)
- The Ginger-haired Boy (cameo)
- Vicarstown Bridge
- Vicarstown Dieselworks
- Knapford
- Tidmouth Sheds
- Kellsthorpe Road
- Brendam Docks
- Duck Pond
- Gordon's Hill (mentioned)
- The Mainland (mentioned)
- John Hasler as Thomas
- Keith Wickham as Edward, Henry, Gordon, Den, Bertie and the Fat Controller
- Rob Rackstraw as James, Toby and a Signalman
- Nigel Pilkington as Percy
- Teresa Gallagher as Emily, Annie, Clarabel and Some Children
- Kerry Shale as Diesel
- Steven Kynman as Paxton and Dart
- Bob Golding as Sidney
- Joseph May as Thomas
- William Hope as Edward and Toby
- Kerry Shale as Henry, Gordon and Diesel
- Rob Rackstraw as James and a Signalman
- Christopher Ragland as Percy
- Jules de Jongh as Emily
- Steven Kynman as Paxton and Dart
- Bob Golding as Sidney
- Keith Wickham as Den, Bertie and Sir Topham Hatt
- Teresa Gallagher as Annie, Clarabel and Some Children
- Going by production order, this is the eighth episode of the twenty-first series. Because of this, it is before Cranky at the End of the Line, New Crane on the Dock and A Shed for Edward, all of which feature Carly, who is absent from her gantry rails at Brendam Docks in this episode. This means that this episode took place before those episodes, as well as The Fastest Red Engine on Sodor, also after this episode in production order, as the opening events of A Shed for Edward takes place during the ending scene of that episode. Additionally, Edward is still at Tidmouth in this episode.
- This episode marks Norman's only appearance in the twenty-first series.
- This episode marked the last of a few things:
- The last appearance of Bertie with his original CGI render and seen without his Series 23 details, because as of Free the Roads he gains new looks.
- Bertie's last appearance in an episode until the twenty-third series episode, Free the Roads.
- Den and Norman's last appearances in an episode until the twenty-third series episode, Diesel Do Right.
- 'Arry and Bert's last appearances in an episode until the twenty-third series episode, Steam Team to the Rescue.
- Annie and Clarabel sing the popular Christmas carol, We Three Kings.
- This is the second episode where every member of the original Steam Team speaks, the first being the nineteenth series episode, The Truth About Toby.
- When Diesel slows down and comes to a stop, a bump sound effect originally used during the fourth through seventh series can be heard.
- The signalman's line "Oh no!" was reused from The Fastest Red Engine on Sodor.
- A shortened version of the episode, narrated by Joseph May as Thomas, can be found on the official YouTube channel and the Nick Jr website.
- This episode marks the sixth time an engine sneezes, with the first five being the first series episode, Whistles and Sneezes, the movie, Thomas and the Magic Railroad, the sixth series episode, Buffer Bother, the thirteenth series episode, Steamy Sodor, and the nineteenth series episode, Henry Spots Trouble.
- Den and Dart have 'Arry and Bert's horns when they and Sidney arrive at Kellsthorpe with the Express.
- Thomas does not emit steam at the end.
- Throughout the episode, Henry is missing his brake pipe and lamp irons.
- In the US dub, when Annie says, "And how will Sir Topham Hatt keep the railway running without any coal?", her lips move to say "the Fat Controller." The same error happens again when she says, "You would be if you'd done what Sir Topham Hatt told you, Thomas."
In Other Languages
|Brazilian Portuguese
|O Grande Congelamento
|얼어붙은 소도어
|Wielki Mróz
|Marele Îngheț
|Сильные морозы
|La Gran Helada
Home Media Releases
- Christmas On Sodor (Direct-to-Home Video)
- The Complete Series 21 (coming soon)
|#01 Springtime for Diesel
|#07 Hasty Hannah
|#13 A Shed for Edward
|#02 A Most Singular Engine
|#08 Cranky at the End of the Line
|#14 The Big Freeze
|#03 Dowager Hatt's Busy Day
|#09 New Crane on the Dock
|#15 Emily in the Middle
|#04 Stuck in Gear
|#10 Unscheduled Stops
|#16 Terence Breaks the Ice
|#05 Runaway Engine
|#11 Philip's Number
|#17 Daisy's Perfect Christmas
|#06 P.A. Problems
|#12 The Fastest Red Engine on Sodor
|#18 Confused Coaches


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EDGE Strategy is a dynamic, global and mission-driven organization, committed to closing the gender gap in the workplace. EDGE Strategy is the commercial arm of the EDGE Certified Foundation and its aim is to prepare organizations for the EDGE Certification, the global leading standard for workplace gender equality.
EDGE stands for Economic Dividends for Gender Equality and is distinguished by its rigor and focus on business impact. EDGE Certification has been designed to help companies not only create an optimal workplace for women and men, but also benefit from it. Its methodology uses a business, workforce analytics approach that incorporates benchmarking, metrics and accountability into the process.
EDGE Certification's diverse customer base consists of 200 large organizations in 37 countries across five continents, representing 24 different industries and encompassing more than one million employees. Organizations that are certified include SAP, IKEA, L'Oréal, UNICEF, the World Bank, the European Central Bank, Firmenich, Zurich Financial Services and Pictet, among many others.
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The person in this role will be part of the client advisory team and will be focusing on developing and continuously improving our workforce analytics capabilities and tools and supporting delivery of client projects.
We require a valid permit to work in Switzerland for this position.


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On Nov. 12, Canfield gymnast Jessica Jones signed her letter of intent to continue her gymnastics career with Penn State University next year.
Jones will head to Penn State early in the summer, but won't begin her collegiate gymnastics until fall.
''I'll start this coming summer,'' she said. ''I'll get adjusted then start gymnastics in August.''
Article Photos
Photo by J.T. Whitehouse, Town Crier
Jessica Jones was surrounded by family and her coach last week as she signed her letter of intent to continue her gymnastics career at Penn State University next year. She is pictured with her grandmother, Elaine Jones; coach, Sandy Sabo; her parents, Rich and Linda Jones; and her younger sister, Erin.
Jessica's career began when her mom enrolled her in the Mommy and Me classes at Youngstown Gymnastics Center in Boardman when she was two. As she grew, so did her passion for gymnastics, and she began perfecting the skills that would see her competing with top level gymnasts.
Her mother, Linda Jones, said Jessica had tried soccer and dance and even the Mommy and Me swimming classes, but she always came back to gymnastics. Her father, Rich Jones, said that was obvious after an injury on the soccer field.
''She twisted her ankle while playing soccer,'' he said. ''She told me she was going to quit soccer. She said she is a gymnast and can't afford that kind of injury.''
Over her gymnastics career, Jessica has risen to the top and competed in the highest level, level 10, for the past six years. She has traveled throughout the United States and garnered a host of state, regional and national titles.
She had a banner year in 2014, qualifying for USA Gymnastics' level 10 national championships in Jackson, Miss., and is now preparing for the Junior Olympics level 10 competitive season.
When Jessica began looking at colleges, she visited Ohio State, Michigan, Arizona State and Arkansas before finally deciding to accept a full scholarship to Penn State.
''I felt Penn State was the best fit for me,'' she said. ''It was also a good fit for the academic side.''
As a 4.119 GPA student at Canfield, she plans to major in kinesiology and exercise science and hopes for a career as a physical therapist or in some form of sports medicine.
''When we visited Penn State, I knew almost immediately this was the school for her,'' Rich said. ''I think she knew, too.''


text:
Dear friends and family,
The Alzheimer's walk this year is Saturday, September 21 in downtown Cocoa Village. Thanks so much for any financial support you can give! So many people now are affected. My mom is still herself in many ways, but she is often confused and she knows that she doesn't remember things. She is a whiz at scrabble and can beat you! Also she is an excellent bridge player and good with figures and calculations. But she cannot remember what happened five minutes ago. Progress is being made against Alzheimer's and that is why we fund raise, to keep those studies and breakthroughs coming! Thank you friends!
My Progress
Thank you for helping us advance Alzheimer's support, care and research!
I have raised
My Goal
My Achievements
Top Team
Mobile Master


text:
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Join Gateway Community CRC and Global Aid Network on an adventure of a life time as we travel to India to experience the work and ministry to the Mukti Mission.
Mukti Mission seeks to provide a "Christ centered home where destitute women and children irrespective of their background are accepted, cared for, transformed, and empowered to be salt and light in the society."
You will experience all that the Mukti Mission has to offer through serving alongside the local partner in the following areas: English medium school, special needs school, vocational training, dairy and agricultural farm, communications office, medical clinic, and daily staff devotional and children's chapel. You will be immersed in the life at the mission and be able to relationships with the girls, women, and staff.
- Dates: Nov 19-Dec 4
- Cost: $3,500
- Tax deductible: Yes
- Funding options: Available
- Additional travel options: Available
- Application deadline: June 30, 2020
To find out more information or the register, please fill out the
Scroll down and check out the video introducing you to the Mukti Mission below (or click here)


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Congrats Mini Cupcake Dozen$29
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You are Your Best Thing. - Toni Morrison


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