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I wonder when we will get to see a rendering of the redesign? Does anyone know if the same firm is designing this latest attempt to get Siggy of the ground. I think that it would be a much better fit and considering it's proposed location, look a little taller than 800ft. I as well, hope that it is a stunning design with a nice crown with dramatic lighting. I would still be happy with the old design of the spire. Something needs to break the lid off of the flat box we call the Nashville skyline. Has anyone seen Charlotte's lately? Wow!
Where is exactly is the info coming from that the tower is 1,030 ft. vice 1,057FT ? I'm not too sure how accurate that article is because it even lists the wrong info for the current tallest which i believe is Library Tower in L.A. not the building that the article refers to.
I totaly agree with you. I remember a while ago i was in the Philidelphia forum, people where so excited when the Comcast Center was beginnning construction. From the way most of the forumers comments sounded, they were alot like ours right now. Mostly they were saying things like "it's about time", or "after all the negative skeptism, it's finnaly happening". I guess that maybe such a large project like these do have setbacks because they are so complex, atleast one can only hope that this is what is going on with Siggy.
I wonder if Tony was to make Siggy 65 floors instead of 70 if that could make a difference in the cost? I sure hope this tower is built, 65 or hell even 60 stories would be better than nothing at all.
I just want to see what the final renderings are going to look like. I hope that they didn't "cheapen" the look of the tower just to cut costs. Gaushell, any answers??
Don't know why, but for some reason the diagram of Signature Tower is no longer on SSP. Anyone know why? Nevermind, I found it. For some reason it was not there when i typed in Nashville to search all building diagrams but after going back to try again it was there.
So do you know, or can you say if the design of the building and/or crown has changed drastically or went back to it's original design? Also, will you be posting a new rendering of the building? Thanks again for oyur updates.
I noticed that the interactive floorplan portion of the Signature Tower website is not functioning. Everything else on the site seems to work fine??? Maybe it's just my computer.
Project Thread/New Construction/Photo du jour/Const. CAMs
bruceman replied to smeagolsfree's topic in NashvilleThanks for refreshing my memory.
Project Thread/New Construction/Photo du jour/Const. CAMs
bruceman replied to smeagolsfree's topic in NashvilleI forget how many floors the Suntrust is supposed to be. Can someone please tell me how many floors are left to go and also, I was wondering if the floor count for the Encore started now that the tower portion is being built or does the 20 stories include what we already see??
Project Thread/New Construction/Photo du jour/Const. CAMs
bruceman replied to smeagolsfree's topic in NashvilleIt looks like they are murals or something to that effect.
It began as a 55 story tower of a completely different design. Looks much better now.
I think that is an old listing that has been on Bidclerck for a while, I suspect that they just never updated it.
Not bad. The new crown is already starting to grow on me. I like the way that the holes in the fins portray the light. Is there still a lit beacon on the top?
Thanks, I think that I can live with that! God that looks stunning. I am stationed in Virginia Beach and currently there is a Westin condo tower under construction and I believe that it's going to be 35-38 stories. I drive by it everyday and they are at the 30th floor now. At the beginning of the summer there were no floors rising and now it's 30 stories! It just goes to show how quickly these projects can progress once started. I always look at it and admire all of you back home who will get to see Siggie rise. It's going to be cool to see happen.


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Although Milly Tseng was artistically inclined from a young age, the impetus to seriously pursue painting came only in the autumn of 2010 when an article in the local newspaper, the Brampton Guardian, captured her attention. The focus of the article, Impressionist painting, which centered around Claude Monet's works, was what inspired Milly into picking up her paint brushes to hone her artistic skills. A keen gardener with a deep love for nature and the outdoors, Milly's source of inspiration is often the blooms in her garden and the places she has visited. Milly works mainly with oils and acrylic and continually seeks out opportunities to experiment with different media and subject matter. Milly has taken classes with artists Nancy Foster and Marianne Broome, and internationally renowned artists, Kelly McNeil and Lynda Kemp. Milly hopes to continue the journey of learning for many years to come…
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Hai Friends....
I have a problem with 'Open Office Org'. I am unable to print some of my documents stored in open office org. Documents with extensions '.doc' are printed normally. But that with '.sxw' of open office are not/ could not be printed directly. My printer is hpdeskjet 656c. Of course as I require the print outs urgently, I copied my documents from open office to MS Word and got them printed.
Cannot we print the documents directly from Open Office.
Please I request somebody to respond.


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Comments for Meet the Cast Member who has played one Miniature Golf course more than 500 times at Walt Disney World
Karen Muto
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As you go through at the starting of this post, auto insurance coverage cons and methods are amazingly typical. If you know how to avoid them, however, obtaining the insurance company that's proper for you is easy and effortless. We hope that this information aids you to make an knowledgeable selection when insuring your motor vehicle.


text: Well that certainly is a stupid headline. But in today's whacko conservative mind, it apparently is true. Adam Smith the founder of modern economics and author of The Wealth of Nations that first outlined the virtues of the emerging capitalist system, wrote the following in his seminal work: The necessaries of life occasion the great expense of the poor. .…Read More »


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Saudi Arabia has become the new centre of activity for Islamic bond issues in the Gulf. Awash with liquidity, banks are finding sukuk an attractive option
Initial public offerings (IPOs) are usually the favourite topic of conversation about the Saudi capital markets. But this year, it is debt, not equity that has captured the attention of companies seeking alternative sources of financing.
For conventional and Islamic bond sales, activity has shifted from the UAE and Qatar and is now centred on the kingdom. Since February, four issuers, either based in the country or Saudi-owned, have come to the market. And more are expected to follow as spreads tighten and banks remain cautious about lending.
Saudi Electricity Company (SEC) was the latest to approach the market, selling SR7bn ($1.9bn) of sukuk (Islamic bonds) in May to local investors. SEC is part of a growing trend for seasoned issuers to return to the bond market. This latest sukuk was its third. The kingdom's largest developer, Dar al-Arkan Real Estate Development Company, issued its fourth sukuk in February, and Saudi-government owed Gulf International Bank (GIB) issued its second in April.
In numbers
- $1.9bn: Value of sukuk sold to local investors by the Saudi Electricity Company in May 2010
- $650m: Value of bonds sold in March 2010 by Banque Saudi Fransi
- SR16bn: Total nominal value of three sukuk listed on the Tadawul by Sabic
Source: MEED
Bullish sentiment
GIB's first issue was a three-year, SR2bn sukuk sold in November last year. The bank had started to market a dollar-denominated issue later the same month, but Dubai World scuppered its plans. The Dubai conglomerate announced it was seeking a standstill on $26bn of liabilities on the day GIB was due to price the dollar issue. The announcement threw both equity and debt markets across the region into turmoil, so GIB cancelled its plans. It was not alone in doing so; sales from a regional pipeline full of deals were cut off mid-flow.
Dar al-Arkan's February sukuk reopened the market. While some analysts said the size of the sukuk was less than expected at $450m, others applauded the high-yield deal as a remarkable achievement, given the low level of confidence in the regional bond markets. The bond was sold with a 10.9 per cent coupon. "I'm bullish on Dar al-Arkan," says one bond trader. "They have a strong business model. It's a good name."
With local banks still wary of lending, more companies are expected to take the opportunity to diversify their funding sources and approach the bond markets.
"The lack of bank credit is helping the bond market," says Paul Gamble, head of research at Riyadh-based Jadwa Investments. "More companies will come to the bond markets as they get comfortable with the process."
Telecoms and petrochemicals firms are among those believed to be gearing up for future issues, according to one Riyadh-based banker. Saudi Aramco subsidiary, Saudi Aramco Total Refining & Petrochemical Company (Satorp) is rumoured to be considering a bond issue to help finance its $10bn Jubail refinery scheme. This raises the prospect of a long-awaited project bond from the Gulf. But most bankers expect much of any future bond activity to be in the financial sector.
The lack of bank credit is helping the bond market. More firms will come … as they get [used to] the process
Paul Gamble, Jadwa Investments
The local Banque Saudi Fransi sold $650m-worth of bonds in March. The transaction was marketed in Europe, Asia and the Middle East. "There were strong bids from Saudi as well, even though it was a dollar issue," says another banker.
Now Banque Saudi Fransi has broken the lull, other issues from commercial banks based inside the kingdom are expected to enter the market. "Banks face an asset-liability mismatch and need to be able to borrow over the longer term," says Gamble. "Across most sectors, debt is under-utilised as a source of corporate financing."
Saudi banks are highlighting the kingdom's fundamentals as a key advantage that differentiates them from financial institutions elsewhere in the region. "Banque Saudi Fransi positioned itself as a Saudi bank and different to the rest of the banks in the GCC due to the inherent strength of the market," adds the second banker.
This has proven to be a successful tactic. Despite the fact that Banque Saudi Fransi is almost two-thirds owned by private investors, it was able to price its bond issue inside that of a $750m bond sale from National Bank of Abu Dhabi (NBAD) earlier in March. NBAD has an iron credit rating as it is 70 per cent owned by the Abu Dhabi government.
Bonds are increasingly attractive to issuers as the spreads on riyal issues tighten on the back of strong demand. Illustrating this, SEC set the initial price guidance on its latest sukuk at 95-105 basis points (bps) over the benchmark Saudi Interbank Offered Rate (Sibor). That was within the 110 bps final pricing on GIB's April sale. From an issuer's perspective at least, this is in turn compares favourably to GIB's November 2009 sukuk, which was sold at about 127 bps over Sibor.
|Bond and sukuk issues in Saudi Arabia 2010
|Dar Al-Arkan
|Real estate
|Banque Saudi Fransi
|Power and water
|Source: MEED
Attractive option
The kingdom is awash with liquidity looking for a home and banks rich with deposits are looking for ways to deploy that money. For treasuries, pension funds and asset managers, the story is the same. The low interest rate environment makes bonds offering a better yield an attractive option. And, although bond issuance has picked up this year, the number of sellers is still small in contrast to the large number of interested investors.
Whether local companies opt to sell bonds locally or internationally depends on their funding needs, and the kingdom has seen a mix. In general, those seeking dollar financing, which tend to be banks already loaded with riyals, have taken their bond road shows abroad. Locally listed, non-finance companies such as SEC and Saudi Basic Industries Corporation (Sabic), recognise that local investors prefer investing in sukuk; their government shareholding also ensures they cater to local tastes. Consequently, they have tended to sell riyal-denominated Islamic bonds. Sabic has three sukuk listed on the Tadawul with a total nominal value of SR16bn.
"Companies go outside the kingdom only if they want to access dollars. They get a tighter-priced deal in riyals," the second banker says.
The case of the Dar al-Arkan issue mixes the two tendancies. The sukuk was sold through an international road show. Significantly, it is one of few Islamic bonds ever to be sold with a 144a designation. This means its documentation clears the bar set by US regulators that allow it to be sold to US investors. Although most of the orders for Dar Al-Arkan's sukuk came from European and Middle East investors amid limited demand from the US, the 144a designation is an achievement. It signals that the company has met more rigorous disclosure requirements.
[Firms] go outside the kingdom only if they want to access dollars. They get a tighter-priced deal in riyals
Bond trader
The kingdom's Capital Market Authority (CMA) is eager to develop a local bond market as part of a general push to modernise the Tadawul, which, on the equity-side, includes the recent introduction of exchange traded funds.
"The CMA is encouraging issuers to sell sukuks or bonds. They have spoken to a lot of investment banks and they have looked at different options to improve the process," the second banker says. The Saudi government itself has issued domestic bonds, building a local yield-curve. At the end of February, treasury bills and government bonds outstanding totalled SR170bn.
Market restrictions
The CMA is also urging issuers to sell paper to the primary market suitable for retail investors. For issuers, this is not such welcome news. The increased level of documentation required to sell to the retail market makes the process much more expensive. And getting retail investors interested is easier said than done. "Sukuk are by nature attractive to institutions," says another banking source.
Despite the high-level support, restrictions remain on which companies can issue and which type of bonds can list. As an immediate consideration, the size of a bond sale is capped at a company's paid-up capital.
Most entities that have come to market are listed, large and well-known. There are very few high-yield deals such as the Dar Al-Arkan sukuk. Companies do not have to be rated to issue bonds or sukuk, but the CMA discourages local funds from buying unrated paper. This shrinks the pool of possible issuers. Furthermore, it is difficult for limited-liability companies – such as large family conglomerates, which would be attractive to investors – to issue paper. This cuts out big names, such as Saudi Oger or Saudi Binladin Group, from
a list of possible issuers.
"There are restrictions on limited-liability companies issuing securities," says a Riyadh-based lawyer. "They would not be able to issue themselves and would have to use a special purpose vehicle (SPV)."
Setting up an SPV in Saudi Arabia presents an immediate obstacle to companies, and in the past issuers have been forced to do this in an offshore jurisdiction. The easier route for large, local family businesses is to leverage their bank relationships and borrow.
For foreign investors, getting a slice of the riyal-denominated bond market is a struggle. First, their funds are extraneous. And second, legally there are restrictions on them buying local issues.
"If they are desperate, there are mechanisms through which it can be done, but it's difficult," says the banking source.
The Tadawul remains a venue for exclusively riyal listings. However, there is talk of permitting dollar-denominated bonds and sukuk to trade. But volumes on the secondary market remain meagre. The Tadawul's bond and sukuk platform launched to some fanfare last year when over-the-counter trading moved to an electronic system. But in the whole of April, there was only one trade during which 1 million notes worth SR995,000 changed hands. Saudi investors, particularly institutions seeking scarce sharia-compliant assets, prefer to buy-and-hold.
"The regulator is encouraging companies to list sukuk," says Abdullah al-Rashoud, chief executive officer of Riyadh-based KSB Capital Group. "But the problem is low liquidity [in the secondary market]. It is frustrating and it makes [retail] investors hesitant to get into the market."
Despite this lack of retail investor interest, Gamble believes the bond market can offer an attractive alternative to the volatility of the equity market. It will be a sign of market maturity when individual investors take this advice and drop the quest for quick profits and move into more stable, fixed-income instruments.
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Eager fans are awaiting the release of "Fast & Furious 7" in 2015. Recently, a new movie still was released on the film's official Facebook page, which shows Paul Walker and Vin Diesel sharing an intense moment. In the picture Walker is facing the camera while Diesel is gazing at him. The caption of the intriguing still reads: "Brian O'Connor in FF7."
Connor is Walker's name in the film series. He is a former LAPD officer and street racer who has an Irish ancestry. He is married to Jordana Brewster's character Mia Toretto. "Fast & Furious 7" will be the last time that Walker will be seen playing Connor on screen. The actor passed away last year in November in a tragic car accident.
He was coming from a charity gala when his car hit an electric pole, thus leading to his untimely demise. Walker's brothers Cody and Caleb Walker finished the remaining scenes of the actor.
Recently, Paul's father Paul Walker III spoke about Cody and Caleb stepping into the shoes of his late son. He said that both the brothers were welcomed in the "F&F" family.
"They said, 'Dad, these people really loved Paul!' And I said, 'Yeah, now they love you. You're the same They're the same as Paul. They're all chipped from the same brick," said Paul's dad to ET Online.
Paul III also said that Walker was attached to all his "Fast & Furious" co-stars and Diesel has no idea "how highly Paul thought of him."
Diesel plays Dominic Toretto in the "F&F" series. He is the head of the Fast 7 gang and just like Connor, is an ace street racer. On many occasions Diesel has fondly spoken about Walker. After Paul's death, Diesel had said in an interview that it was the gloomiest time of his life
"It's a heavy thing, Michael. You know?" Diesel said. "I grew up in the bouncer world, and we lost people while we were bouncing. But the brotherhood in Paul Walker was something completely different," said the actor to show hosts of "Live with Kelly and Michael," as reported by MTV.
"Fast & Furious 7" will release in April 2015. Film's official name is "Furious 7."


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Get your holiday money with Debenhams
- Get £5 off when you spend £20 or more (T&Cs apply)
- Click and collect your order from over 100 Travel Money bureaus
- Home delivery available
- Get cash in over 60 currencies
Debenhams is a British multinational department store, founded in London in 1778. Besides selling a multitude of clothes, furniture and household items, Debenhams also offer financial services, including Credit Cards, Insurance and Travel Money.
Debenhams' Travel Money service makes ordering online easy and efficient. It offers competitive foreign exchange rates on global currencies, charges zero commission and offers a free delivery on every travel money transaction you make.
Good for any potential traveller to bear in mind, however, is that while the traditional way of getting travel money is all well and good, there's a range of digital apps that can make the process even simpler. These include Starling, Revolut and N26. If these new age solutions float your boat, you can read our guide to learn more about them. For the best way to get travel money with Tesco, though, stay right here for all the info.
Debenhams offers several services, with added benefits for Debenhams Card holders:
Sign up today using the button below to load £5 onto your card for free.
For your security as well as Debenhams', there are some limits on how much travel money you can order.
On a travel card: £2,000
Cash: Smaller sums should always be accessible, but if ordering any exceptional amounts, get in touch with Debenhams' ahead of your trip to make sure they have the funds available and you have all the paperwork they may require.
Debenhams will buy back any remaining funds (only notes, no coins) after your trip. It's worth noting that Debenhams card holders will get preferential rates when selling currency back.
Debenhams offers bureaus in their stores, so getting your travel money should be quick and easy. Should you require an exotic currency or a larger sum of money, make sure to call ahead to make sure they have the funds available.
If you choose to use the Debenhams Travel Money Card and it is lost or stolen, their 24/7 Lost & Stolen services can protect your funds.
There are no fees to exchange money with Debenhams, although you should pay close attention to the terms and conditions when using a travel card as fees may be incurred.
Digital banking apps offer a really convenient alternative to the established ways of setting up your holiday spend. Big names such as Starling, N26 and Revolut provide a zero transaction and zero withdrawal fee service that can be topped up from your phone. You don't have to worry about currency conversion, as the app takes care of this by itself. The down side of such apps though is that they're very much reliant on your phone – so don't lose it!
We update our data regularly, but information can change between updates. Confirm details with the provider you're interested in before making a decision.
What currency for Prague?
If I order currency on a debenhams credit card will I pay interest on the transaction if I pay off the amount within 24 hours
Can I put more money on my Debenhams travel card while in the US?
Hi. Could you tell me whether it is possible to order currency and pay by Paypal?
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- Code 2000101
- Packing 1
- Weight 100g
Category: Food
Category: Food
Himalayan Berry Swadisht Pachan Churan, fortified with Leh Berry and various other natural ingredients, has been specifically formulated to enhance the digestive system by fighting several stomach disorders. An Ayurvedic preparation with no side effects, this Churan has been made tastier for you to relish your taste buds, while taking care of the digestive disorders. Enriched with Leh Berry, Bael and several other natural ingredients, it can help you relieve indigestion, constipation and gastric disorders. Get your pack of Himalayan Berry Swadisht Pachan Churan today and say goodbye to digestive problems.
Keeps the stomach free from several disorders
Helps improve digestion
Helps relieve constipation and gastric disorders
Helps in loss of appetite
This miracle fruit is rich in vitamins and minerals, which provides the wealth of essential nutrients to keep the body active and healthy. It is extremely helpful in improving metabolism and enhancing the digestive system.
Owing to its laxative properties, it can help in effective cleansing of the intestines and is very useful in healing constipation.
It is considered as a prebiotic fibre, which helps in controlling gas and digestive discomfort.
It benefits the whole digestive tract. This amazing fruit can increase appetite and improve digestion and absorption.
Take 3-5 gm after every meal
It is preferable to take it with warm water
We are proud members of the Federation of Indian Chambers of Commerce and Industry (FICCI) and Indian Direct Selling Association (IDSA).


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Massachusetts' Baker-Polito administration has announced $721,500 in grants to six academic institutions and labor organizations to establish workforce training and development programs to support the state's emerging offshore wind industry.
The awards include a $200,000 commitment from Vineyard Wind's Windward Workforce Fund. The programs will be located at institutions in Barnstable, Bourne, Fall River, New Bedford, Newton and Martha's Vineyard.
"Growing a workforce for the construction, installation and operation of offshore wind will create opportunities for Massachusetts residents to take advantage of the thousands of jobs created by this emerging industry," says Massachusetts Lt. Gov. Karyn Polito.
The institutions receiving funding are as follows:
- Bristol Community College (BCC) – $200,000 to establish basic safety training and basic technical training to Global Wind Organization (GWO) standards at its campus in New Bedford.
- Massachusetts Maritime Academy (MMA) – $184,000 to establish all five modules of GWO basic safety training at its campus and develop an "introduction to offshore wind" course for MMA cadets. A crew transfer training facility, supported by the Massachusetts Clean Energy Center (MassCEC), will be operational this summer.
- UMass Amherst – $105,500 to complete the initial design of and develop most of an offshore wind professional certificate program to be offered at the Mt. Ida campus in Newton.
- Pile Drivers and Divers Local 56 – $100,000 to sponsor trade union members for GWO basic safety training at Massachusetts Maritime Academy.
- Cape Cod Community College – $66,570 to develop and deliver a suite of courses to introduce students and workers to careers in offshore wind.
- Adult Continuing Education – Martha's Vineyard – $65,000 to partner with BCC and MMA to provide on-island courses and training to support basic safety and technical certification, as well as offshore wind technician certificates.
"The offshore wind industry is poised to create new renewable energy jobs, and these programs represent an important development as the commonwealth readies for the first large-scale project in the nation," says Stephen Pike, CEO of MassCEC. "With Massachusetts' proud maritime heritage, robust innovation economy and academic and training assets, the state is very well-positioned to grow a workforce that will contribute to this new American industry for years to come."
In April 2018, MassCEC released a report on the workforce needs and economic impact of the emerging offshore wind industry, finding that the deployment of 1,600 MW of offshore wind is estimated to support between 2,300 and 3,100 direct job years over the next 10 years and generate a total economic impact in Massachusetts of between $678 million to $805 million.


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Order Sunday by 8pm for free contactless delivery on Wednesday between 3pm-7pm. We will send a text 30 minutes before to ensure you're around to take items off your step and into your fridge or freezer.
Meal Kits Include:
* 5 types of Organic Vegetables
* 2-3 Organic Dry Pantry Basics
* 1 Vert Pantry Specialty
* 1 Vert Secret Recipe to have fun with
* 1 Large Entree
* 2 Fresh Prepared Meals


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Co. Antrim → Kilconway → Grange of Dundermot Civil Parish → Dundermot
We don't know what Electoral Division Dundermot is in. Dundermot is in the Civil Parish of Grange of Dundermot. Dundermot is in the Barony of Kilconway. Dundermot is in Co. Antrim
The Irish name for Dundermot is Dun Diarmaida
Dundermot is on Logainm.ie: Dundermot.
It is located at 54° 57' 20" N, 6° 20' 45" W.
Dundermot has an area of:
Nationwide, it is the 49721st largest townland that we know about
Within Co. Antrim, it is the 1516th largest townland
Dundermot borders the following other townlands:
We don't know about any subtownlands in Dundermot.
Curious to see who lived in Dundermot in the past? Maybe even seeing scans of their handwritten census returns?
Dundermot was added to OpenStreetMap on 3 Dec 2014 by Stephen_Co_Antrim.


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Rangiya among top 10 cleanest rail stations
In a big leap, Assam's Rangiya railway junction under the Northeast Frontier Railway (NFR) zone has been declared as India's seventh cleanest 'A' category railway station. The previous year, it was in the 78th position. However, the NFR zone as a whole has slipped three spots in one year to finish as the dirtiest among the country's Top 10 zones, according to an audit report on station cleanliness. Jogbani station of Bihar under NFR has been ranked as the dirtiest in the country by the survey. Among the stations in the region under NFR zone, Silchar is the dirtiest whose national ranking is 392 among 407 stations.
While Vishakhapatnam has emerged as the cleanest station in Al category, Beas earned the top spot among 'A category stations. The survey was conducted by Quality Council of India (QCI) in 407 major railway stations (75 A1 category and 332 A category stations). The survey parameters adopted were evaluation of process of cleanliness in parking, main entry area, main platform, waiting room by direct observation by the assessors and passenger feedback.
Guwahati, the region's biggest station and one of the only two Al category stations in the NFR zone, has improved the maximum in cleanliness index, taking a leap from 353rd spot in 2016 to 37th in 2017. The other Al station, New Jalpaiguri, slumped from 49th position to 132.
File photo of Rangiya Railway Station


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Sometimes timing, place and circumstances all align and something happens that you don't expect.
So, last week, I shared that I did a photo shoot of a porch and Kriste and I had a couple of dogs for company. As I worked on the shoot, I thought the time is coming soon when our family will get a dog. We've been thinking about it for over a year, but never pulled the trigger on actually getting one.
One reason was that it felt like Jeff and I wanted different things. He wanted a specific breed, an Australian Shepherd, so he was looking at puppies on breeder websites. I wanted to adopt a rescue dog, one that was a little older, maybe around two, who was already past the puppy stage, was house-trained, and well-behaved.
So, we both looked now and then, but never spotted one we were both excited about.
This weekend, Jeff went on a retreat to New Hampshire, so it was just me and the boys. On Saturday morning we tagged along to a local "cat farm" my parents were visiting.
It's not really a cat farm, but that's what we call it. It's actually a couple who has a love for animals and they take in strays, rescue animals, and cats who aren't good candidates for adoption. They have over 70 cats and that may sound like mayhem, but they take amazing care of the animals on their 30+ acre farm. They also have horses, a couple of dogs, chickens, etc. It's a little animal haven.
My parents were visiting, because she took in their cat that they weren't able to keep. He was wetting in the house frequently and then didn't fair well as an outdoor cat roaming a suburban neighborhood. He's now at the farm and doing really well there. So, my parents visit him every few months and also bring out cat food and litter to support the owners.
My boys like going to the farm to play with the cats and dogs. This was my first time going, but they had been before. When we arrived, a sweet dog was bounding around as I pulled the car into the driveway. He didn't jump up on us or bark, but wagged his tail, licked our fingers and sat still when we pet his head.
I gave the cats some attention and played more with the dog, Sebastian. The boys were loving on him, too, throwing his squeaky bone and scratching his ears. It's a big thing for Calvin, who has always been pretty fearful of dogs.
I had the thought again that we should get a dog soon and, when we do, I hoped he would be just like this one. Sebastian seemed perfect. I mentioned that to my dad and he said he bet we could have Sebastian. Oh, I wouldn't want to take their dog! I wouldn't even ask that.
After the visit, we got in the car and I mentioned to the owner that we have been considering getting a dog for a long time and if she came across a rescue dog that would be great for a family to let us know.
"Well, we have a black one right here who would love a family like yours!"
"Seriously? You would part with him?"
She confirmed that they would and shared that she and her husband were just talking about how they love having him, but he really needed to be with a family with some kids, so he had more action and attention. Even though they weren't actively trying to re-home him, they were hoping one day the right family would come along for him.
And we seemed to be it.
I snapped a picture of him and said I would talk to my husband about it, we'd think about it and let her know.
We went out to lunch and I texted Jeff as soon as we sat down. I started off the text with, "I'm serious about this…" and proceeded to tell him about Sebastian and how I think he is "our dog". I didn't really know what to expect from Jeff, because, while we had talked about getting a dog, actually getting one didn't seem like something that would happen any time soon. And I've never sent him a "honey, can we bring an animal into our house" kind of text before. Usually it's an antique hutch, settee, or buffet.
His response was, "Get him."
So, we did.
Meet Sebastian.
A few things about him… He's a 1 1/2 year old who was adopted as a stray from Arkansas by the couple we got him from. As best as anyone can tell, he's a border collie with possibly some shepherd and spaniel mixed in. He is already house-trained, crate-trained, and very obedient. So, the breed makes Jeff happy and the fact that he's past the puppy stage makes me happy.
And the fact that he is a dog makes the boys happy! Calvin, our youngest, has especially taken to him. They had a snuggle-fest all over the floor the first day he was in our house and he's been saying things like, "Our house is so much more fun now."
Marshall is ready to teach him to do every trick in the book.
And I'm enjoying having a no-excuses reason to walk a lot and bringing a "studio dog" with me to work…
I will be getting him a proper dog bed, but I put together a makeshift one out of a remnant of upholstery foam and an old blanket.
Sebastian approved.
I always loved the idea of bringing our future dog to the studio with me, so he/she wouldn't be lonely during the day, but I figured that wouldn't be very realistic. He's such a good dog, though, that it's working really well. He doesn't get into anything and just hangs out. Of course, that might change once he gets more "comfortable", but things are going well so far.
And I set up a little treat jar for him, and other dogs who might visit, in a jar one of my sweet readers, Barbara, gave me as a gift.
There's a lot to get used to, like dog park etiquette, dirty floors, grooming, riding in cars, and walks in our jammies…
And I'm brand new to the world of poop baggies, dog beds, leashes, and other gear, so I'd love if you'd share your tips, suggestions, and favorite things with me.
Another chapter of life begins…


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2969 West 119th Avenue
Westminster, CO
Sold at $325,000
3 Bedrooms
2 Bathrooms
1,492 Sq.Ft.
Low maintenance living with amazing views! This beautiful second story condo sits on a corner which provides you a slightly larger driveway. The Ranch Creek Villas is a quiet neighborhood that provides terrific amenities such as: Clubhouse, Pool, Fitness Center, Trails, Snow removal and so many more. The master bedroom has its own bathroom, large walk-in closet and sliding glass door. New CHAMPION Windows have been installed for you to enjoy your beautiful views. This home features 2 additional bedrooms and another full bath. There is a spacious living room with a cozy gas fireplace. The home is in a great location, near shopping, dining, and entertainment, with easy access to I-25 and Hwy 36 for any commutes to Denver or Boulder.
3 bedrooms
2 bathrooms
1,492 Sq.Ft.
1 car garage
0 Sq.Ft.
Adams County County
Condo, Townhome, Duplex
built in 2003
mls number 7535464
Amazing Mountain Views
Corner lot
Contact Bret Brewer for more information about this listing.
B² Group - Distinct Real Estate LLC
1511 W 124th Ave, Suite 100
Westminster, CO 80234
Cell: (303) 906-2322 Direct: (720) 460-1551
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Photo taken in:CarigradYear when photo was taken:1918Country name at time of photo:TurkeyCountry name today:Turkey
This is the back of the photo of my granduncle, Jakov Kalef, in Carigrad where he served in the military. The picture was taken in 1918. It reads: ?For long-lasting memory to my dear and beloved wife Lenka from your husband Jakov M. Kalef Carigrad 12 May 1918.? [Editor's Note: it looks like the words ?For the European War? were added to this at some later point. This refers to WWI.]


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Hobbycraft Clearance sale, grab yourself a bargain...
21st February 2016
Halfords :: 10% Off Boardman Performance range of ...
21st February 2016
sapphire crystal uk replica watches case back in the bottom plus a special glass box slot. Extremely thin watch (9.85 mm) highlights the replica rolex tourbillon movement advanced complex features of the sense of harmony, brightness and high-end finishing. The meticulous replica watches enthusiasm for the use of the track with minute-like scale and with arrows and stars for the characteristics of white rolex replica enamel lacquer plate and pendulum carved with decorative patterns is inspired from Geo.


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BEGIN:VCALENDAR VERSION:2.0 PRODID:ILLC Website BEGIN:VEVENT UID:/NewsandEvents/Events/Conferences/newsitem/495 0/3-4-October-2013-2nd-APMP-meeting-Association-fo r-the-Philosophy-of-Mathematical-Practice-Urbana-I L-U-S-A- DTSTAMP:20130324T000000 SUMMARY:2nd APMP meeting: Association for the Phil osophy of Mathematical Practice, Urbana IL, U.S.A . DTSTART;VALUE=DATE:20131003 DTEND;VALUE=DATE:20131004 LOCATION:Urbana IL, U.S.A. DESCRIPTION:The Second International Meeting of th e Association for the Philosophy of Mathematical P ractice (APMP) will be held October 3-4, 2013 at t he University of Illinois at Urbana-Champaign, USA . The APMP aims to foster the philosophy of math ematical practice, that is, a broad outward-lookin g approach to understanding mathematics that engag es with mathematics in practice---including issues in history of mathematics, the applications of ma thematics, cognitive science, etc. This meeting wi ll be the first part of a four day meeting on prob lems and prospects in the philosophy of mathematic s. The second part will be the Fourteenth Midwest PhilMath Workshop (MWPMW 14): we hope APMP partici pants will also stay for this second part. For m ore information, see http://institucional.us.es/ap mp/index_APMP2013.htm The call for papers is now open, with a deadline of April 30, 2013. X-ALT-DESC;FMTTYPE=text/html:
\n The Second International Meeting of the Assoc iation for the\n Philosophy of Mathematical Practice (APMP) will be held\n October 3-4 , 2013 at the University of Illinois at\n U rbana-Champaign, USA.\n\n
The AP MP aims to foster the philosophy of mathematical\n practice, that is, a broad outward-looking a pproach to\n understanding mathematics that e ngages with mathematics in\n practice---inclu ding issues in history of mathematics, the\n applications of mathematics, cognitive science, et c. This\n meeting will be the first part of a four day meeting on problems\n and prospect s in the philosophy of mathematics. The second par t\n will be the Fourteenth Midwest PhilMath W orkshop (MWPMW 14): we\n hope APMP participan ts will also stay for this second part.\n\n \n \n
For more information, se e\n http://insti tucional.us.es/apmp/index_APMP2013.htm\n\n
The call for paper s is now open, with a deadline of April 30, 2013.\ n\n


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Join us for a free evening of art, history, music and Museum Store shopping!
Two Exhibit Openings:
Suggin Territory: The Marvelous World of Folklorist Josephine Graham opens in the Arkansas Made Gallery.
Suyao Tian: Entangled Beauty opens in the 2nd Floor Gallery
The Year of Arkansas Beer, sponsored by Historic Arkansas Museum Foundation and presented by Arkansas Brewers Guild, continues in April with Lost Forty Brewing's Belgian Blonde.


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I recently visited Pune to unwind from the busy life in Bombay. It has got some interesting new places but has its old charm intact. While exploring the lanes, my eyes were caught by a bright yellow bungalow, which was converted into a quaint casual bistro named Cafe Pondi. So, I decided to explore more of this place and as soon as I entered, I saw the simple yet very elegant interiors done with wood and the theme revolves around yellow-blue-white-brown colours. It's a pure vegetarian cafe serving south Indian cuisine influenced by Tamil and Pondicherry. The sky was in it's most romantic form and I was sipped on some hot chocolate and munched on some yummies they offered.
The information in this post might be outdated
Take A Break From The Humdrum Life of The City & Explore This Quaint Bistro
What Makes It Awesome?
How Much Did It Cost?
Best To Go With?
Family, Big Group, Bae, and Kids.


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New computers increase information delivery options
The Auckland HC library has recently installed new computers on which practitioners, who are researching using the library's electronic resources, are able to store PDFs which they can then email to themselves. Previously the only delivery option for PDFs was for practitioners to print them out at the library. The new computers now also have Microsoft readers installed for Word and Excel. These readers allow practitioners to open and print off documents from their webmail accounts.
Last updated on the 3rd June 2015


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Squash is considered one of the best sports for building stamina and flexibility. Throughout the year, the OAC offers top-notch program for children of various ages. Our non-competitive students learn the game of squash in a fun, safe, and encouraging environment and our competitive team trains to compete in tournaments at the advanced level. Our squash professional instructs fundamental skills and drills.
Elite Training (Selection only)
Tuesdays/Thursdays 6:00-7:15pm
$200 (1x/week) | $375 (2x/week)
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Serious training for players aspiring in rankings and Silver events.
Mondays/Wednesdays 7:30-8:30pm | Sundays 10:30-11:30am
$15 drop-in | $150 for and 10 sessions
Saturday Beginners
Non-competitive level for learning fundamental skills and enjoying the game of squash in a fun environment.
U10: 10:00-11:00 am
11 and up: 11:00am-12:00pm
$150 (OAC Member) | $185 (OAC Non Member)


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Off-the-beaten-path route to admire Dalí's life & artwork
Dalí's Theatre-Museum, world's largest surrealistic object
Scenic drive through the rocky coastline of Costa Brava
Artwork inspired by Gala—Dalí's wife & muse
A complete surrealistic & intimate experience
Off-the-beaten-path route to admire Dalí's life & artwork
Dalí's Theatre-Museum, world's largest surrealistic object
Scenic drive through the rocky coastline of Costa Brava
Artwork inspired by Gala—Dalí's wife & muse
A complete surrealistic & intimate experience
Live Commentary in English. Non-summer route.
Total price is 95 €, taxes included
Live Commentary in English. Summer route.
Total price is 95 €, taxes included
Explore Catalunya
Carrer del Palau de la Musica, 1
Barcelona 08003
Step into the surreal world of Salvador Dalí. Delve into the artist's life, artwork, and unconditional love for Gala – the love of his life and muse – as you wander through his hometown, Figueres. Marvel at the Mae West room or at one of the many clock paintings in his theatre-museum.
Leaving Barcelona behind, your first stop is Figueres, Salvador Dalí's hometown. Keep your eyes wide open and prepare for one of the strangest buildings you have ever seen, Dalí's Theatre-Museum. As your guide gives you the ins and outs of the structure, analyse the bizarre façade crowned with huge eggs. Inside, a different universe unravels with the most complete collection of Dalí's work.
Costa Brava was another of Dalí's favourite places. Take in the beauty of the rocky coastline, whitewashed Mediterranean-style houses, narrow alleys and sandy beaches. Enjoy some time to relax before returning to Barcelona.
Guided tour of Figueres
Admission to Dalí's Theatre-Museum
Roundtrip transport between Barcelona and Figueres
Commentary in English
Maximum group size is 15 people.
This activity is not wheelchair accessible.
Check-in is 15 minutes prior to the booked tour start time.
Please note: The Dali House will be closed on the 1st of January, and from the 6th of January until the 11th of February. It is still possible to see the house from the outside.
Expedia Verified Reviews
4.3 out of 5
Everything was perfect!
Aida T
United States
The guide Arnau is very sweet and great. As long as he is concerned, the trip is great. The arrangement of the trip is a little problematic. The last stop of the three in the tour--a so-called great spot in Brava Coast-- is pointless. The beach is just an ordinary community beach surrounded by a widely spread local residence area--we needed to walk a considerable distance among plain local houses (after a long day) to reach a short patch of beach to which none of us even felt like dipping feet into. Admit it, it is just not worthy of international tourists--not even local tourists. By the way, bottled water is not an expensive item and we are very willing to pay for it. Since there is no shop to buy bottle water in two of the stops--the Gala Castle and the anonymous beach, I highly recommend you to include at least two bottles of bottled water for each guest--include the cost in our fee, we'd love to pay for it. The least service the company can think of.
A verified traveller
So grateful to see Dali museum, his wifes castle, and a cool beach house. The dtive is long and AC was inadequate for the heat, the guide was nice but at timrs difficult to understand. Excellent tour in most respects though and definitely worth doing.
Daisy S
United States


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Literacy Week
Thu, 10/17/2019 - 11:31am
It's Literacy Week at Pava'ia'i Elementary School and in honor of the celebration, a door competition was held, featuring popular animated films like Moana and Beauty and the Beast. Pictured are some of the staff members of the Pavaiai Special Education Division. [photo: courtesy]


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Mezz-Armchair Travel Book Discussion
Our theme this month is "National Parks" and we'd love to have you join us for a discussion of our beautiful national heritage. Bring a book or map or other things reflecting something you like about one or more of our parks, or just bring yourself!
Event date:
Tuesday, April 23, 2019 - 11:00am to 12:00pm
Event address:


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Chapter 17 Trajectory Analysis
17.1 Overview
Many biological processes manifest as a continuum of dynamic changes in the cellular state. The most obvious example is that of differentiation into increasingly specialized cell subtypes, but we might also consider phenomena like the cell cycle or immune cell activation that are accompanied by gradual changes in the cell's transcriptome. We characterize these processes from single-cell expression data by identifying a "trajectory", i.e., a path through the high-dimensional expression space that traverses the various cellular states associated with a continuous process like differentiation. In the simplest case, a trajectory will be a simple path from one point to another, but we can also observe more complex trajectories involve branching to multiple endpoints.
A related concept is that of "pseudotime", defined as the positioning of cells along the trajectory that quantifies the relative activity of the underlying biological process. For example, the pseudotime for a differentiation trajectory might represent the degree of differentiation from a pluripotent cell to a terminal state. This metric allows us to tackle questions related to the global population structure in a more quantitative manner. (It is worth noting that pseudotime is rather poorly named as it may or may not have much to do with actual time. For example, one can imagine a continuum of stress states with cells moving in either direction over time, but the pseudotime will only increase in one direction.)
In this section, we will demonstrate several different approaches to trajectory analysis using the haematopoietic stem cell (HSC) dataset from Nestorowa et al. (2016).
#--- data-loading ---#
sce.nest <- NestorowaHSCData()
#--- gene-annotation ---#
ens.mm.v97 <- AnnotationHub()[["AH73905"]]
anno <- select(ens.mm.v97, keys=rownames(sce.nest),
keytype="GENEID", columns=c("SYMBOL", "SEQNAME"))
rowData(sce.nest) <- anno[match(rownames(sce.nest), anno$GENEID),]
#--- quality-control-grun ---#
stats <- perCellQCMetrics(sce.nest)
qc <- quickPerCellQC(stats, percent_subsets="altexps_ERCC_percent")
sce.nest <- sce.nest[,!qc$discard]
#--- normalization ---#
clusters <- quickCluster(sce.nest)
sce.nest <- computeSumFactors(sce.nest, clusters=clusters)
sce.nest <- logNormCounts(sce.nest)
#--- variance-modelling ---#
dec.nest <- modelGeneVarWithSpikes(sce.nest, "ERCC")
top.nest <- getTopHVGs(dec.nest, prop=0.1)
#--- dimensionality-reduction ---#
sce.nest <- denoisePCA(sce.nest, technical=dec.nest, subset.row=top.nest)
sce.nest <- runTSNE(sce.nest, dimred="PCA")
#--- clustering ---#
snn.gr <- buildSNNGraph(sce.nest, use.dimred="PCA")
colLabels(sce.nest) <- factor(igraph::cluster_walktrap(snn.gr)$membership)
## class: SingleCellExperiment
## dim: 46078 1656
## metadata(0):
## assays(2): counts logcounts
## rownames(46078): ENSMUSG00000000001 ENSMUSG00000000003 ...
## rowData names(3): GENEID SYMBOL SEQNAME
## colnames(1656): HSPC_025 HSPC_031 ... Prog_852 Prog_810
## colData names(4): cell.type FACS sizeFactor label
## reducedDimNames(3): diffusion PCA TSNE
## altExpNames(1): ERCC
17.2 Obtaining pseudo-times
17.2.1 Cluster-based minimum spanning tree
The TSCAN package employs a simple yet effective approach to trajectory reconstruction. It clusters cells to summarize the data into a smaller set of discrete units, computes cluster centroids by averaging the cell coordinates and then forms the minimum spanning tree (MST) across centroids. The MST is simply an undirected acyclic graph that passes through each centroid exactly once and can be thought of as the most parsimonious structure that captures the transitions between clusters. We demonstrate below on the Nestorowa dataset (Figure 17.2), computing the centroids in the low-dimensional space to take advantage of data compaction and denoising (Chapter 9).
# TODO: get the TSCAN authors to allow me to plug in existing
# dimensionality reduction and clustering results, rather than
# forcing users to go along with their defaults.
by.cluster <- aggregateAcrossCells(sce.nest, ids=colLabels(sce.nest))
centroids <- reducedDim(by.cluster, "PCA")
dmat <- dist(centroids)
dmat <- as.matrix(dmat)
g <- igraph::graph.adjacency(dmat, mode = "undirected", weighted = TRUE)
mst <- igraph::minimum.spanning.tree(g)
For reference, we can draw the same lines between the centroids in a \(t\)-SNE plot (Figure 17.3). It is then straightforward to identify interesting clusters such as those at bifurcations or endpoints. Keep in mind that the MST is generated from distances in the PC space and is merely being visualized in the \(t\)-SNE space; its interpretation is not compromised by the distortions required to obtain a two-dimensional visualization.
# TODO: stuff this into a function somewhere.
pairs <- Matrix::which(mst[] > 0, arr.ind=TRUE)
coords <- reducedDim(by.cluster, "TSNE")
group <- rep(seq_len(nrow(pairs)), 2)
stuff <- data.frame(rbind(coords[pairs[,1],], coords[pairs[,2],]), group)
plotTSNE(sce.nest, colour_by="label") +
geom_line(data=stuff, mapping=aes(x=X1, y=X2, group=group))
We obtain a pseudotime ordering by projecting the cells onto the MST. In other words, we move each cell onto the edge of the MST to which it is closest; the pseudotime is then calculated as the distance along the MST from this new position to a "root node". For our purposes, we will arbitrarily pick one of the endpoint nodes as the root, though a more careful choice based on the biological annotation of each node may yield more relevant orderings (e.g., picking a node corresponding to a more pluripotent state).
# TODO: for the love of god, we definitely need to move this into a function!
.map2edges <- function(points, center, edge.ends, previous) {
all.distances <- list()
all.pseudo <- list()
edge.len <- list()
# Computing distance of each point from each edge.
# Edges defined from 'center' to 'edge.ends'.
for (i in rownames(edge.ends)) {
edge.end <- edge.ends[i,]
delta <- center - edge.end
max.d <- sqrt(sum(delta^2))
delta <- delta/max.d
centered <- t(t(points) - center)
proj <- as.numeric(centered %*% delta)
proj <- pmax(0, pmin(proj, max.d))
mapped <- outer(proj, delta)
dist <- sqrt(rowSums((centered - mapped)^2))
all.distances[[i]] <- dist
all.pseudo[[i]] <- proj
edge.len[[i]] <- max.d
all.distances <- do.call(cbind, all.distances)
all.pseudo <- do.call(cbind, all.pseudo)
chosen <- colnames(all.distances)[max.col(-all.distances)]
# Flipping the distance of points to the previous node,
# in order to enforce a directional pseudo-time.
dist.previous <- 0
if (!is.na(previous)) {
on.previous <- chosen==previous
dist.previous <- edge.len[[previous]]
previous.proj <- dist.previous - all.pseudo[on.previous,previous,drop=FALSE]
if (all(on.previous)) {
return(list(dist=dist.previous, pseudo=list(previous.proj)))
# Filling out the branches, where points are NA for a branch's
# pseudo-time if they were assigned to another branch.
output <- list()
for (leftover in setdiff(rownames(edge.ends), previous)) {
empty <- rep(NA_real_, nrow(points))
if (!is.na(previous)) {
empty[on.previous] <- previous.proj
current <- chosen==leftover
empty[current] <- all.pseudo[current,leftover]
output[[leftover]] <- empty
list(dist=dist.previous, pseudo=output)
originals <- reducedDim(sce.nest, "PCA")
cluster <- colLabels(sce.nest)
starting.cluster <- names(igraph::V(mst)[igraph::degree(mst)==1])[1]
collated <- list()
latest <- starting.cluster
parents <- NA_character_
progress <- list(rep(NA_real_, length(cluster)))
cumulative <- 0
while (length(latest)) {
new.latest <- new.parents <- character(0)
new.progress <- list()
new.cumulative <- numeric(0)
for (i in seq_along(latest)) {
curnode <- latest[i]
all.neighbors <- names(igraph::adjacent_vertices(mst, curnode, mode="all")[[1]])
in.cluster <- cluster==curnode
mapped <- .map2edges(originals[in.cluster,,drop=FALSE], center=centroids[curnode,],
edge.ends=centroids[all.neighbors,,drop=FALSE], previous=parents[i])
edge.len <- mapped$dist
pseudo <- mapped$pseudo
collected.progress <- list()
for (j in seq_along(pseudo)) {
sofar <- progress[[i]] # yes, using 'i' here.
sofar[in.cluster] <- pseudo[[j]] + cumulative[i]
collected.progress[[j]] <- sofar
all.children <- setdiff(all.neighbors, parents[i])
if (length(all.children)==0) {
collated[[curnode]] <- collected.progress[[1]]
} else {
new.latest <- c(new.latest, all.children)
new.parents <- c(new.parents, rep(curnode, length(all.children)))
new.progress <- c(new.progress, collected.progress)
new.cumulative <- c(new.cumulative, rep(cumulative[i] + edge.len, length(all.children)))
latest <- new.latest
parents <- new.parents
progress <- new.progress
cumulative <- new.cumulative
tscan.pseudo <- do.call(cbind, collated)
plotTSNE(sce.nest, colour_by=I(rowMeans(tscan.pseudo, na.rm=TRUE)), text_by="label") +
geom_line(data=stuff, mapping=aes(x=X1, y=X2, group=group))
TSCAN gains several advantages from using clusters to form the MST. The most obvious is that of computational speed as calculations are performed over clusters rather than cells. The relative coarseness of clusters protects against the per-cell noise that would otherwise reduce the stability of the MST. The interpretation of the MST is also relatively straightforward as it uses the same clusters as the rest of the analysis, allowing us to recycle previous knowledge about the biological annotations assigned to each cluster.
However, the reliance on clustering is also a double-edged sword. If the clusters are not sufficiently granular, it is possible for TSCAN to overlook a trajectory if the entirety of the trajectory occurs in a single cluster. In addition, the MST does poorly at handling more complex events like cycles (e.g., the cell cycle, obviously) or bubbles (e.g., multiple differentation paths to the same terminal cell type). Whether or not this is a problem depends on the complexity of the global structure of the population of interest.
17.2.2 Principal curves
To identify a trajectory, one might imagine simply "fitting" a one-dimensional curve so that it passes through the cloud of cells in the high-dimensional expression space. This is the idea behind principal curves (Hastie and Stuetzle 1989), effectively a non-linear generalization of PCA where the axes of most variation are allowed to bend. We use the slingshot package (Street et al. 2018) to fit a principal curve to the PC coordinates, which yields a pseudotime ordering of cells based on their relative positions when projected onto the curve.
sce.sling <- slingshot(sce.nest, reducedDim='PCA')
## [1] 89.44417 76.33613 87.88466 76.93112 82.40780 72.09984
Here, we fitted the principal curve to the PC space for the same reasons as described above. We can then visualize the literal path taken by the fitted curve in that space (Figure 17.5).
# Setting up the colors.
colors <- colorRampPalette(brewer.pal(11,'Spectral')[-6])(100)
plotcol <- colors[cut(sce.sling$slingPseudotime_1, breaks=100)]
# Creating a PCA plot.
plot(reducedDim(sce.sling, "PCA"), col = plotcol, pch=16, asp = 1)
lines(SlingshotDataSet(sce.sling), lwd=2, col='black')
For other dimensionality reduction results, we color by the pseudotime ordering to identify the direction of the trajectory (Figure 17.6). This is effectively a continuous generalization of the coloring by cluster assignment observed in other chapters.
sce.sling <- runUMAP(sce.sling, dimred="PCA")
# TODO: make ggcells robust to random crap in the colData().
# Also need to add a function to auto-generate a path.
sce.sling$cell.type <- sce.sling$FACS <- NULL
ggcells(sce.sling, mapping=aes(x=UMAP.1,
y=UMAP.2, col=slingPseudotime_1)) +
geom_point() + scale_color_viridis()
The previous
slingshot() call assumed that all cells in the dataset were part of a single one-dimensional trajectory, which fails to consider more complex events like bifurcations. To accommodate this, we use our previously computed cluster assignments to build a rough sketch for the global structure in the form of a MST across the cluster centroids. Each path through the MST from a designated root node is treated as a lineage; principal curves are then simultaneously fitted to all lineages, with some averaging across curves to encourage consistency in regions that are common to multiple lineages. This allows
slingshot() to capture branching events based on divergence in the principal curves (Figure 17.7).
sce.sling2 <- slingshot(sce.nest, cluster=colLabels(sce.nest), reducedDim='PCA')
plot(reducedDim(sce.sling2, "PCA"), col="grey80", pch=16, asp = 1)
lines(SlingshotDataSet(sce.sling2), lwd=2, col='black')
When operating in this mode,
slingshot() produces one pseudotime ordering for each principal curve. Cells not assigned to a particular curve will be assigned
NA values for that curve's ordering. We can use
slingshotBranchID() to determine whether a particular cell is shared across multiple curves or is unique to a subset of curves (i.e., is located "after" branching). In this case, we can see that most cells jump directly from a global common segment (
1,2,3) to one of the curves (
3) without any further hierarchy, i.e., no noticeable internal branch points.
curve.assignments <- slingBranchID(sce.sling2)
## curve.assignments
## 1 1,2 1,2,3 1,3 2 2,3 3
## 435 6 892 2 222 39 60
For larger datasets, we can speed up the algorithm by approximating each principal curve with a fixed number of points. By default,
slingshot() uses one point per cell to define the curve, which is unnecessarily precise when the number of cells is large. Indeed, the approximated curves in Figure 17.8 are quite similar to those in Figure 17.7.
sce.sling3 <- slingshot(sce.nest, cluster=colLabels(sce.nest),
reducedDim='PCA', approx_points=100)
plot(reducedDim(sce.sling3, "PCA"), col="grey80", pch=16, asp = 1)
lines(SlingshotDataSet(sce.sling3), lwd=2, col='black')
17.3 Characterizing trajectories
17.3.1 Changes along a trajectory
17.3.2 Changes between lineages
17.4 Finding the root
17.4.1 Overview
17.4.2 Entropy-based methods
17.4.3 RNA velocity
Session information
R version 4.0.0 Patched (2020-05-01 r78341)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: Ubuntu 18.04.4 LTS
Matrix products: default
BLAS: /home/luna/Software/R/R-4-0-branch/lib/libRblas.so
LAPACK: /home/luna/Software/R/R-4-0-branch/lib/libRlapack.so
[1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
[3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8
[5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8
[7] LC_PAPER=en_US.UTF-8 LC_NAME=C
[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
attached base packages:
[1] parallel stats4 stats graphics grDevices utils datasets
[8] methods base
other attached packages:
[1] viridis_0.5.1 viridisLite_0.3.0
[3] RColorBrewer_1.1-2 slingshot_1.6.0
[5] princurve_2.1.4 scater_1.16.0
[7] ggplot2_3.3.0 SingleCellExperiment_1.10.1
[9] SummarizedExperiment_1.18.1 DelayedArray_0.14.0
[11] matrixStats_0.56.0 Biobase_2.48.0
[13] GenomicRanges_1.40.0 GenomeInfoDb_1.24.0
[15] IRanges_2.22.1 S4Vectors_0.26.0
[17] BiocGenerics_0.34.0 OSCAUtils_0.0.2
[19] BiocStyle_2.16.0
loaded via a namespace (and not attached):
[1] BiocSingular_1.4.0 DelayedMatrixStats_1.10.0
[3] assertthat_0.2.1 BiocManager_1.30.10
[5] highr_0.8 GenomeInfoDbData_1.2.3
[7] vipor_0.4.5 yaml_2.2.1
[9] pillar_1.4.4 lattice_0.20-41
[11] glue_1.4.1 digest_0.6.25
[13] XVector_0.28.0 colorspace_1.4-1
[15] cowplot_1.0.0 htmltools_0.4.0
[17] Matrix_1.2-18 pkgconfig_2.0.3
[19] bookdown_0.19 zlibbioc_1.34.0
[21] purrr_0.3.4 scales_1.1.1
[23] processx_3.4.2 RSpectra_0.16-0
[25] BiocParallel_1.22.0 tibble_3.0.1
[27] farver_2.0.3 ellipsis_0.3.1
[29] withr_2.2.0 magrittr_1.5
[31] crayon_1.3.4 evaluate_0.14
[33] ps_1.3.3 nlme_3.1-147
[35] FNN_1.1.3 beeswarm_0.2.3
[37] tools_4.0.0 lifecycle_0.2.0
[39] stringr_1.4.0 munsell_0.5.0
[41] irlba_2.3.3 callr_3.4.3
[43] compiler_4.0.0 rsvd_1.0.3
[45] rlang_0.4.6 grid_4.0.0
[47] RCurl_1.98-1.2 BiocNeighbors_1.6.0
[49] igraph_1.2.5 bitops_1.0-6
[51] labeling_0.3 rmarkdown_2.1
[53] gtable_0.3.0 codetools_0.2-16
[55] R6_2.4.1 gridExtra_2.3
[57] knitr_1.28 dplyr_0.8.5
[59] uwot_0.1.8 ape_5.3
[61] stringi_1.4.6 ggbeeswarm_0.6.0
[63] Rcpp_18.104.22.168 vctrs_0.3.0
[65] tidyselect_1.1.0 xfun_0.13
Hastie, T., and W. Stuetzle. 1989. "Principal Curves." J Am Stat Assoc 84 (406): 502–16.
Nestorowa, S., F. K. Hamey, B. Pijuan Sala, E. Diamanti, M. Shepherd, E. Laurenti, N. K. Wilson, D. G. Kent, and B. Gottgens. 2016. "A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation." Blood 128 (8): 20–31.
Street, K., D. Risso, R. B. Fletcher, D. Das, J. Ngai, N. Yosef, E. Purdom, and S. Dudoit. 2018. "Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics." BMC Genomics 19 (1): 477.


text: Hi, computed gotos are a feature of modern compilers [1]. They can be used as a faster replacement for switch-based VM [2]. Many programming languages have VMs implemented in computed gotos (at least, Ruby and Python). The computed goto version is faster because of two reasons [2]: * The switch does a bit more per iteration because of bounds checking. * The effects of hardware branch prediction. I have applied this optimization to VM of Lua 5.3.2, file src/lvm.c [3]. It was very easy, because VM uses macros vmdispatch, vmcase and vmbreak. I have redefined these macros and created a dispatch table. It passes Lua basic tests (path/lua -e"_U=true" all.lua) [4]. My benchmark [5] shows speedup of 1.12: $ time ./src/lua.orig ~/lang-bench/f3/test.lua 499500 real 0m28.208s user 0m28.166s sys 0m0.004s $ time ./src/lua ~/lang-bench/f3/test.lua 499500 real 0m25.066s user 0m25.030s sys 0m0.000s This commit is a draft, not a final contribution. If a compiler doesn't support computed gotos, the switch based implementation should be used, as before. [1] https://gcc.gnu.org/onlinedocs/gcc/Labels-as-Values.html [2] http://eli.thegreenplace.net/2012/07/12/computed-goto-for-efficient-dispatch-tables [3] https://github.com/starius/lua/commit/b10eb122ad1e6f94e3ebf100179515ed66921756 [4] http://www.lua.org/tests/#basic [5] https://github.com/starius/lang-bench/blob/master/f3/test.lua -- Best regards, Boris Nagaev


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Alot has been said about Tommy D's Verse on the brand new song "Keep Forgetting" off Koby's "Young Legend" Album which many have described to be Shorts he fired on The Kopala Brothers Chef 187 and Macky2 which also included top names in the game like Slapdee,Mampi and Ruf Kid.
On the verse Tommy D tackled a number of issues were the beginning of Hip Hop is concerned.Thats the time we saw the birth of a "Beef" between Lusaka Rappers and Kopala Rappers, He also include the effort he put in to help many of these Hip Hop stars we have today.But he complains about not being recorgnised for that he did for the Music industry particulary the "Hip Hop" Genre.
From the day the song was dropped,we have heard mixed reactions from his fellow artist and music lovers.
Macky2 responded with a post on his social media platforms were he Referred to Tommy D as "Bitter" See below
Mampi also added a voice to a tweet by one of Tommy D's fans Chisenga
So now after all this,we need to ask yourselves some questions. Were has Tommy D been while those he helped in the early stages of their career are making it big in the industry? Did his career end at some point for them not to include him on any of their projects?
Maybe after we answer theses questions we can conclude weather they are shots or facts.


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Dansko Dansko WinonaWinona
Fit Survey:
50% True to size
83% Felt true to width
62% Moderate arch support
Item Information
- Dansko Footwear Size Chart
- Make your long workdays breeze by with the Winona slip-on from Dansko®.
- Premium leather uppers with stitch details and a round toe.
- Features 3M Scotchgard™ treated uppers for durability and stain-resistance.
- Easy slip-on design with dual goring.
- Soft and breathable foam-backed fabric linings.
- Features Dansko Natural Arch™ technology designed with lasting arch support for all-day comfort.
- Durable slip-resistant rubber outsole suitable for dry, wet, and oily/wet surfaces.
- Imported.
- Product measurements were taken using size 38 (US Women's 7.5-8), width Regular. Please note that measurements may vary by size.
- Weight of footwear is based on a single item, not a pair.
- Measurements:
- Heel Height: 2 in
- Weight: 9 oz
- Platform Height: 1 in
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