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30: Houston Astros
We all knew the move from the NL to the AL would be a tough change for the Astros. We proved to be correct as the 'Stros fished a MLB worst 51-111, the worst record Houston had seen in a long time. Hopefully in 2014, the Astros will be back and ready for another year, of torture.
29: Chicago Cubs
Ah, the Cubs, the team that has not won a world series in 105 years. The team has good crop of young talent and some other established players but division the Cubbies are in is deadly. With the Reds and Cardinals two of the NL's best teams in the division. Maybe in 2014, the new mascot Clark the Cub will help the team end the drought or at least, win a few more games.
28: Miami Marlins
At the beginning of last year Marlins fans were ready to call it quits with their beloved team who had won it's first world series in 1997. After Jeffery Loria dumped all of the star players except Giancarlo Stanton, Marlins fans were furious. At least the faithful few that were left at the end of the season got to see Henderson Alvarez throw no-hitter against the Detroit Tigers, which will never happen again.
27: San Diego Padres
The Friars, had a pretty bad year, lets get that out of the way. But like the Cubs, they have tons of young talent that is ready to go when needed. By signing Josh Johnson the Padres have checked one need off their list, but there is plenty more to go.
26: Chicago White Sox
Remember just a few years ago when the White Sox were considered the best team in the AL Central before the Tigers reign? Well, those days are over. Paul Konerko is retiring after the 2014 season, and the players the Sox have just don't seem to cut it.
25: Minnesota Twins
Just like the White Sox, the Twins had their glory days of 2009-2011, but those days are long gone. Joe Mauer is getting older and the Twins have lost a lot of key players that helped with that run. But with the additions of Phil Hughes and Rickey Nolasco, that should help a bit.
24: Milwaukee Brewers
The Brew Crew has lost more then they have gained this offseason, including two important players such as Corey Heart to the Seattle Mariners and Norachika Aoki to the Rockies. The Brewers did sign fomer Yankees and Indians third baseman Mark Reynolds but they will need more then just that.
23: New York Mets
The Mets had a fairly successful offseason signing former Yankees center fielder Curtis Granderson and A's ace Bartolo Colon. I expect the Mets to have a much better season then they did last year but David Wright and Granderson need more protection around the lineup.
22: Philadelphia Phillies
The Phils, have the potential to be good but father time has got the best of them, Ryan Howard, Chase Utley and Cole Hammels are all aging. A big subtraction was Roy Halladay who decided to call it quits after 16 years in the MLB. The signing of Marlon Byrd should help fill a void or two.
21: Toronto Blue Jays
The Jays had the highest expectations of the 2013 season. They had signed Jose Reyes, Josh Johnson, Melky Cabrea and traded for R.A. Dickey. But, last season was a complete train wreck, the Jays finished last place and the hype is lower this year but Jays fans are itching for more, hopefully even a playoff run.
20: Baltimore Orioles
The Orioles have a good team, great hitters including Adam Jones and Chris Davis. But the O's traded away one of the best closers in the game to the Oakland A's, Jim Johnson. Later, the O's had appeared to sign a closer that is equally as good Grant Balfour but the deal fell through. Also, the pitching isn't where it needs to be for the O's to be a deadly team.
19: Washington Nationals
The Nats had a tough 2013 campaign compared to 2012 when they won the division with ease and almost made it to the world series. The Nats fans are hungry for the playoffs, so the team decided to bring in Doug Fister from the Detroit Tigers which is a very smart move. The Tigers got Steve Lombardozzi and another prospect in exchange. If lucky, the Nats could make another playoff run in 2014.
18: Seattle Mariners
The Mariners by far, made the biggest splash of the off season signing former star Yankees second baseman Robinson Cano to a 10 year $240 million dollar deal. They also made a few other splashes landing Logan Morrison and Corey Heart. The M's should be much better this year.
17: Cleveland Indians
Last season it was a great year for the Indians, who punched their first ticket to the playoffs since 2007, lead by former Red Sox skipper Terry Francona, who I might add won AL Manager of the year. This was the first of many good things to come, and I look forward to watching Cleveland play in the future.
16: Colorado Rockies
The Rockies have had had their ups and downs the past few seasons. A emotional retirement of Todd Helton was a down but the Rocks have rebounded and signed Drew Subbs and Boone Logan and I think they have a good chance for a winning record in 2014.
15: Los Angeles Angels
Yet another team with high expectations that failed in 2013. At the beginning of last year, the team pulled off a huge splash signing Josh Hamilton to a 5 year $125 million dollar deal. Hamilton struggled at the beginning of the year and Albert Pujols ended his season by injury. The Angels have a lot to gain back this year with the addition of Raul Ibanez, there should be some good power in the lineup along with, Hamilton, Pujols and Mike Trout.
14: Tampa Bay Rays
The Rays were great last year, won the wild card but then were defeated by Boston in the ALDS. They signed former closer Grant Balfour for a two year deal. So why are they 16th? The hitting. The Rays have two legit hitters Evan Longoria and James Loney. But besides that, nothing.
13: San Francisco Giants
The Giants, a team that just swept the Tigers in the World Series and had high expectations for 2013 but surprisingly, the Giants season did not go as planned. An injured Angel Pagan did not help and Matt Cain was not up to snuff. Hopefully SF can rebound from a poor season. Signing Micheal Morse and Tim Hudson should help with a void in left and spot in the pitching rotation.
12: Kansas City Royals
Was it the magical BBQ sauce that did it? Who knows, but the Royals kept finding ways to win. I think they should be even better after signing Omar Infante, Norachika Aoki and Danny Valencia. I expect the Royals to be very good and maybe even steal a playoff spot.
11: Arizona Diamondbacks
Two words, Paul Goldshmidt. The guy is a stud, he is the pride of the Diamondbacks and I think they will put him to good use in the next couple of years, I expect Arizona to have a good record with the good talent such as newly traded for, Mark Trumbo.
10: Pittsburgh Pirates
Raise the jolly rodger! Pirates fans last year witnessed one of the greatest pirates teams of the last twenty years. Andrew McCutchen won NL MVP and all was good for the fans of the black and gold. I expect the the Bucos have a very good chance of making another wild card.
9: Cincinati Reds
There is a lot of debate about which team is better, the Reds or the Pirates. I like the Pirates more but I honestly think the Reds are a better team. They have good hitting in Joey Votto and Brandon Phillips and good pitching in Matt Latos and yea the guy who throws 101, (Chapman).
8: Atlanta Braves
The Braves have the hitting, they have the pitching. Atlanta has two Uptons in the field, I expect the Braves to win the East by a large margin this year as none of the other teams compete. Even though they lost Brian McCann to the Yankees, the Braves still have a very scary team.
7: Oakland Athletics
The miracle team of 2012 has turned into the power house team of 2013 and beyond. The A's have turned themselves into one of the deadliest teams in the AL. With the addition of Jim Johnson, the A's look set and ready to go for 2014. Along with Cespedes, the A's have a lot to look forward to in 2014, but they have to look out for Texas, who has also re-stocked with stars.
6: Texas Rangers
After a surprising exit from the playoffs handed courtesy of the Tampa Bay Rays, the re-stocked Rangers signed stars such as Prince Fielder who came from detroit in exchance for Ian Kinsler. The Rangers also signed Shin-Soo Choo to a seven year deal. I expect Texas to win the division and rebound from a bad season.
5: Los Angeles Dodgers
The Dodgers pushed themselves into first place when Yasiel Puig arrived to the MLB. He quickly helped the Dodgers get back where they needed to be at the beginning of the season. The Dodgers have one of the best pitching staff's in the MLB. The Dodgers have stars like Clayton Kershaw, Zack Grienke and Hyun-Jin Ryu. Even though LA missed out on the Tanaka sweepstakes, they are one of the best teams in baseball
4: Boston Red Sox
The 2013 World Series Champion Boston Red Sox. Why aren't they number one? Because they lost some players who played key roles in the playoffs last year. Jacoby Ellsbury went to the arch rival Yankees, Jarod Saltalamachia went to the Florida Marlins and Franklin Morales. But, the BoSox signed AJ Pierzinski and re-signed Mike Napoli, that's why they are Number four.
3: New York Yankees
The 2013 Yankees were most likely one of the worst Yankee teams of the last 25 years. They were dead last in most hitting categories. Angry Yankees fans prompted Hal Stienbrener and Brian Cashman to make some major moves in the offseason. Well, the Yankees hands down had the best offseason they have had in 10 years and it was better then most teams. The Yanks spent a whopping $503 million dollars on stars, Brian McCann (5yrs $85m) Jacoby Ellsbury (7yrs $153m) Carlos Beltran (3yrs $45m) and the star Japanese pitcher Masahiro Tanaka chose the Yanks as his team (7yrs $155m). This will make NY instant World Series Contenders.
2: Detroit Tigers
The Tigers have always been good. They have gotten better this year, even though they lost Omar Infante and Prince Fielder, they have gained Ian Kinsler, Joe Nathan, Rajai Davis and Joba Chamberlin. Oh yea and then there's Miguel Cabrera, he is a flat out BEAST. The Tigers will be back and better then ever, even without the Prince.
1: St. Louis Cardinals
Each year the Cardinals seem like the best team in the MLB, and this year is no different. Though St.Louis lost one of their best hitters in Carlos Beltran to the Yankees, they signed Jhonny Peralta which was a steal at 4yrs and $55m. The Cardinals will continue to be one of the best teams in baseball hands down, and they will be in the hunt for the 2014 World Series.


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Safe & Wild - [DUO]
Safe & Wild
- Two Square - Approximately 25" x 25"
- Black Printed Canvas Board (chalkboard look) + White + Chosen Frame Finish
- Lightweight signs (2-5 pounds Each) making decorating and rearranging a breeze!
- Hanging hardware is not included
- Designed, crafted, and assembled in our Wood Shop in East Texas
- We ship all over the US!
- Frames are one-of-a-kind and no two will look the same.
Photo by @timelesstaylorphotography

subset: commoncrawl


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Re: [RC] Weight & BC - Truman PrevattEric Rueter wrote:
A question for the group. Below you mention weighing the first 12 or so riders. This lead me to ask why 12? I thought it was only the first 10 horses across the finish line who were eligible to stand for BC. So I took out my brand new - handy dandy - pocket size rule book and looked up the verbage..."Rule 9.3 Under the AERC system, all of the first ten finishing equines are eligible for consideration whether ridden by Junior, Featherweight, Lightweight, Middleweight or Heavyweight riders."
The way I read it is "across the finish line." I have crossed the finish line in 11th place and had two horses in front of me pulled at the finish line but still could not stand for BC.
"It is forbidden to kill; therefore all murderers are punished unless they kill in large numbers and to the sound of trumpets." Voltaire
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Ride Long and Ride Safe!!


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You will find that Winter Park soapstone countertops are excellent for preparing food on because they are so hard and durable. This material is especially ideal for kitchen work surfaces, because you can use them for decades before seeing any outward signs of wear whatsoever. These countertops are available in a variety of textures, so you will almost certainly be able to find one that will meet your needs perfectly. Despite what you may think, having soapstone countertops in Winter Park installed in your kitchen doesn't cost very much, so you can save money while still getting what you need. By having these countertops installed in your kitchen, you will also increase the overall resale value of your home significantly.
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The soapstone countertops Winter Park, FL has to offer come with quite a few different benefits that you will need to know about before deciding whether or not to have them installed in your home. Winter Park soapstone countertops are known for being extremely durable, so you can count on them to stand the test of time. If you want countertops that are going to look amazing in your home, these are certainly worth taking a close look at. Soapstone countertops in Winter Park, FL have a very unique aesthetic that can improve the overall look of any kitchen.
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THE MINI CENTURION 230v
Like Its brother the Centurion, the 230v Mini Centurion filters at a nominal 30litres per minute. The Tower filters to One Micron removing all the heavy contamination before passing the fuel into the two water removal filters.
The unit includes 2 x 3 metre fuel pipes. (Extra fuel pipes are available).
One metre Inlet Lance with the Y Strainer taking out the larger particles of 30 microns plus.
One meter Outlet Lance designed to stir up contamination at approximately 20psi with around a 9″ fan, great for washing down the sides of the tank.
Tankbusters also offer a number of different length lances, including the Right Angle Outlet Lance that reaches out into longer tanks.


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The Qur'an
1 - Al Fatiha (The opening)
2 - Al Baqara (The cow)
3 - Al Imran (The family of Imran)
4 - An Nisa (The women)
5 - Al Maida (The food)
6 - Al Anam (Cattle)
7 - Al Araf (The heights)
8 - Al Anfal (Spoils of war)
9 - Al Tawba (Immunity)
10 - Yunus (Jonah)
11 - Hud
12 - Yusuf (Joseph)
13 - Ar Rad (The thunder)
14 - Ibrahim (Abraham)
15 - Al Hijr (The rock)
16 - An Nahl (The bee)
17 - Bani Israil (The Israelites)
18 - Al Kahf (The cave)
19 - Maryamn (Mary)
20 - Ta-Ha
21 - Al Anbiya (The prophets)
22 - Al Hajj (The pilgrimage)
23 - Al Muminun (The believers)
24 - An Nur (The light)
25 - Al Furqan (The discrimination)
26 - Ash Shuara (The poets)
27 - An Naml (The ant)
28 - Al Qasas (The narrative)
29 - Al Ankabut (The spider)
30 - Ar Rum (The Romans)
31 - Luqman
32 - As Sajda (The adoration)
33 - Al Ahzab (The allies)
34 - Al Saba (The Saba)
35 - Al Fatir (The angels)
36 - Ya Sin
37 - As Saffat (Those who set up ranks)
38 - Saad
39 - Az Zumar (The troops)
40 - Al Ghafir (The forgiver)
41 - Fussilat (Explained in detail)
42 - Ash Shura (The council)
43 - Az Zukhruf (Gold)
44 - Ad Dukhan (Drought)
45 - Al Jathiya (Kneeling)
46 - Al Ahqaf (The dunes)
47 - Muhammad
48 - Al Fath (Victory)
49 - Al Hujraat (The apartments)
50 - Qaf
51 - Adh Dhariyat (The scatterers)
52 - At Tur (The mount)
53 - An Najm (The star)
54 - Al Qamar (The Moon)
55 - Ar Rahman (The beneficent)
56 - Al Waqia (The event)
57 - Al Hadid (Iron)
58 - Al Mujadila (The pleading woman)
59 - Al Hashr (Exile)
60 - Al Mumtahana (The examined woman)
61 - As Saff (The ranks)
62 - Al Jumua (The congregation)
63 - Al Munafiqun (The hypocrites)
64 - At Taghabun (Manifestation of losses)
65 - At Talaq (Divorce)
66 - At Tahrim (Prohibition)
67 - Al Mulk (The kingdom)
68 - Al Qalam (The pen)
69 - Al Haqqa (The reality)
70 - Al Maarij (Ascending stairways)
71 - Nuh (Noah)
72 - Al Jinn (The Jinn)
73 - Al Muzzammil (The enshrouded one)
74 - Al Muddaththir (The cloaked one)
75 - Al Qiyama (Resurrection)
76 - Al Insan (Man)
77 - Al Mursalat (The emissaries)
78 - An Naba (The tidings)
79 - An Naziat (Those who yearn)
80 - Abasa (He frowned)
81 - At Takwir (The folding up)
82 - Al Infitar (The cleaving)
83 - Al Mutaffifin (The cheats)
84 - Al Isnhiqaq (Splitting open)
85 - Al Buruj (The stars)
86 - At Tariq (The morning star)
87 - Al Ala (The most high)
88 - Al Ghashiya (The overwhelming)
89 - Al Fajr (The dawn)
90 - Al Balad (The city)
91 - Ash Shams (The Sun)
92 - Al Lail (The night)
93 - Ad Duhaa (The brightness of day)
94 - Al Inshirah (The expansion)
95 - At tin (The fig)
96 - Al Alaq (The clot)
97 - Al Qadr (The power)
98 - Al Bayyina (Clear proof)
99 - Al Zalzala (The shaking)
100 - Al Adiyat (The assaulters)
101 - Al Qaria (The calamity)
102 - At Takathur (Abundance of wealth)
103 - Al Asr (The time)
104 - Al Humaza (The slanderer)
105 - Al Fil (The elephant)
106 - Quraish (The Quraish)
107 - Al Maun (Almsgiving)
108 - Al Kauthar (Abundance)
109 - Al Kafirun (The disbelievers)
110 - An Nasr (Divine support)
111 - Al Lahab (The flame)
112 - Al Ikhlas (The unity)
113 - Al Falaq (Dawn)
114 - An Nas (Mankind)
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Next »
Ahmad Ali
Ali Qarai
Amhad Khan
Hilali & Khan
Muhammad Sarwar
Muhammad Shakir
Sahih Intl
Talal Itani
Wahihuddin Khan
Yusuf Ali
Al Hajj (The pilgrimage) - الحج
ذَٰلِكَ وَمَن يُعَظِّمْ شَعَٰٓئِرَ ٱللَّهِ فَإِنَّهَا مِن تَقْوَى ٱلْقُلُوبِ
Ahmad Ali
All this, and honouring the offerings to God, comes from purity of heart.
Ali Qarai
That. And whoever venerates the sacraments of Allah—indeed that arises from the Godwariness of hearts.
Amhad Khan
So it is; and whoever reveres the symbols of Allah – this is then part of the piety of the hearts.
All that; and whosoever venerates God's waymarks, that is of the godliness of the hearts.
That, and whoever honors (the) Symbols (of) Allah then indeed, it (is) from (the) piety (of) the hearts.
Thus it is. And whosoever respecteth the rites of Allah, then verily it is from piety of the hearts.
Hilali & Khan
Thus it is [what has been mentioned in the above said Verses (27, 28, 29, 30, 31) is an obligation that mankind owes to Allah]. And whosoever honours the Symbols of Allah, then it is truly from the piety of the heart.
Such is the fact. And whoso venerates the sanctity of all that have been ordained as symbols of Allah surely does so because it is part of the true piety of the hearts.
Muhammad Sarwar
To respect the symbols of God is the sign of a pious heart.
Muhammad Shakir
That (shall be so); and whoever respects the signs of Allah, this surely is (the outcome) of the piety of hearts.
That (is the command). And whoso magnifieth the offerings consecrated to Allah, it surely is from devotion of the hearts,
All that; and, he who venerates the waymarks of Allah, surely it is from the piety of the hearts.
Sahih Intl
That [is so]. And whoever honors the symbols of Allah - indeed, it is from the piety of hearts.
Talal Itani
So it is. Whoever venerates the sacraments of God—it is from the piety of the hearts.
Thalika waman yuAAaththim shaAAaira Allahi fainnaha min taqwa alquloobi
Wahihuddin Khan
Thus it is. He who honours the symbols set up by God shows the piety of his heart.
Yusuf Ali
Such (is his state): and whoever holds in honour the symbols of Allah, (in the sacrifice of animals), such (honour) should come truly from piety of heart.
لَكُمْ فِيهَا مَنَٰفِعُ إِلَىٰٓ أَجَلٍ مُّسَمًّى ثُمَّ مَحِلُّهَآ إِلَى ٱلْبَيْتِ ٱلْعَتِيقِ
Ahmad Ali
, There are advantages for you in these (cattle) up to a time, then their place is the ancient House for sacrifice.
Ali Qarai
You may benefit from them until a specified time. Then their place of sacrifice is by the Ancient House.
Amhad Khan
In the cattle are benefits for you up to a fixed time and then they are to be brought to the Free House.
There are things therein profitable to you unto a stated term; thereafter their lawful place of sacrifice is by the Ancient House.
For you therein (are) benefits for a term appointed; then their place of sacrifice (is) at the House the Ancient.
For you in them are benefits for a term appointed, and thereafter the destination is toward the ancient House.
Hilali & Khan
In them (cattle offered for sacrifice) are benefits for you for an appointed term, and afterwards they are brought for sacrifice unto the ancient House (the Haram - sacred territory of Makkah city).
You may derive benefit (from sacrificial animals) until an appointed time. Thereafter their place (of sacrifice) is near the Ancient House.
Muhammad Sarwar
There are benefits for you in the (sacrificial offerings) of God until the appointed time when you slaughter them as your offering near the Ancient House.
Muhammad Shakir
You have advantages in them till a fixed time, then their place of sacrifice is the Ancient House.
Therein are benefits for you for an appointed term; and afterward they are brought for sacrifice unto the ancient House.
In them, you have benefits until an appointed time. After their place of sacrifice is at the Ancient House.
Sahih Intl
For you the animals marked for sacrifice are benefits for a specified term; then their place of sacrifice is at the ancient House.
Talal Itani
In them are benefits for you until a certain time. Then their place is by the Ancient House.
Lakum feeha manafiAAu ila ajalin musamman thumma mahilluha ila albayti alAAateeqi
Wahihuddin Khan
You may benefit from the animals for an appointed time. Then they must be sacrificed at the Ancient House.
Yusuf Ali
In them ye have benefits for a term appointed: in the end their place of sacrifice is near the Ancient House.


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Baltimore is the largest city in the state of Maryland and the 24th largest city in the United States. Founded in 1729, Baltimore is the second largest seaport in the Mid–Atlantic United States and is situated closer to Midwestern markets than any other major seaport on the East Coast. Baltimore's Inner Harbor was once the second leading port of entry for immigrants to the United States and a major manufacturing center. After a decline in manufacturing, Baltimore shifted to a service‑oriented economy, with the Johns Hopkins Hospital and University serving as the city's top two employers.
The population of the city of Baltimore was 621,342 as of July 1, 2012. The Baltimore Metropolitan Area has grown steadily to approximately 2.7 million residents in 2010; the 20th largest in the country. Baltimore is also a principal city in the larger Baltimore–Washington metropolitan area of approximately 8.4 million residents. Washington, D.C. is located approximately 40 miles from Baltimore, where many D.C. workers live due to the lower cost of living.
Baltimore's Equitable Building was designed by local architect Joseph Evans Sperry. The structure was completed in 1891, and is the oldest building in Monument Square. Built on the former site of Barnum's Hotel, the Equitable was considered the city's first skyscraper and contained offices, a billiard room, a barber shop and Turkish baths in the basement. The building is adjacent to Charm City's two courthouses and the Battle Monument. Its exterior survived the Great Fire of 1904.
Located at 10 North Calvert Street, The Equitable Building is well situated in the heart of Baltimore's City Center adjacent to the Courthouse and Police Headquarters. Downtown Baltimore is the economic center of Greater Baltimore and home to the city's fastest-growing neighborhoods. City Center encompasses Historic Charles Street, Charles Center, Market Place, and the Financial District. The CBD offers light rail transportation to Washington, DC and a more affordable rental market for those employed in the nation's capital. Very importantly, the entrance to the area's subway station is 50 feet from the door to The Equitable Building.
In addition to the many businesses and the growing number of apartments, City Center is home to an increasing number of restaurants, shops, and nightlife offerings. Although it's still the region's business center with approximately 100,000 employees, City Center has emerged as one of the most active development areas for new housing.


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For credit despite completed private crediteintrag there is undeniable often needs. The private credit is for many consumers a big nuisance. But she keeps getting into life when it comes to signing new contracts. Because before the contract signing the private credit is queried.
And not just when a new car is to be financed. Also with all other regular credits, numbers on account, new telephone contracts, leases and much more the private credit is queried. If negative entries occur during the query, this complicates the conclusion of the contract.
Because negative entries always point to payment failures that must or have been massive. Differences are namely in current and completed private crediteinträge.
Credit despite completed private credit entry – meaning
Particularly annoying is a negative private credit when a loan is to be taken. Even if the private credit entry has already been completed, the financier can get in the way. He does not have to approve the loan despite having completed the private credit entry. After all, the prospect once had financial problems. And no one can make sure they do not come back.
Why, therefore, forgive a loan despite completed private credit entry?
Not always, the loan request can be postponed until the private credit calmed down again. Completed entries are known to be deleted no later than three years after completion. However, if you do not have that much time, you have to take the credit despite having completed the private credit entry with the small hurdle.
This is relatively easy if the creditor is given a guarantor. So an additional borrower who has at best no negative private credit entry and therefore can secure the loan.
How should you proceed with the recording?
If the borrower is aware that his private credit is in negative territory, it is advisable to plan the borrowing well. This prevents embarrassing moments at the bank or in the business where the loan is to be taken.
So the second borrower should be located as early as possible. He must submit his documents when applying for the loan. In addition, the credit agreement for the loan must be signed by both borrowers despite the completed private credit entry.
Should be acted without a second borrower, then taking the loan, despite completed private credit entry a little more difficult. Because then a donor must be found off the well-known ways. And that is not always easy.
The foreign credit
A possibility for the admission of a loan despite completed private credit entry would arise then, if the loan is taken up abroad. Foreign credits for German citizens usually come from Soulcredit bank. The bank grants small loans without asking private credit, but as a borrower you have to be able to meet some requirements.
In addition to a fixed income and a permanent residence in Germany, a German bank account must be available. The desired loan amount may not be higher than 7500 Euro. And the loan despite completed private credit entry must be repaid within 40 months to the bank.
The loan despite completed private credit entry via a credit intermediary
The second possibility of borrowing without the query of private credit would be via a credit intermediary. However, it is important to look very carefully who wants to provide the money. There are some black sheep in the industry, so this way can lead to a dead end.
It is good if you turn to one of the big intermediaries like Maxcredit or Crediter. These are not only very experienced in arranging loans, but also working reputably. It is recommended to name as many collateral as possible. This increases the chances of a loan and lowers the cost of it.
In general, however, it is advisable to take the loan despite the completed private credit entry only if it can not be avoided. Otherwise it can happen that the next debt crisis is already waiting.


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There is a loose correlation between the number of digital products you managed to launch and your level of success as an indie maker. The more you do it, the better you get at it. That's the assumption the 12 Products in 12 Months challenge is based upon.
It takes a long time to grow a business, but failing to generate revenues upon launch is a sign there is probably no market for what is being offered. In this case, it's best to pivot by starting again from scratch.
In other words, success comes down to how long and how quickly one can launch, iterate upon, or abandon new complex products.
You can move faster by buying third-party tools, but it will impact your runway. I'm 100% convinced that entrepreneurship is a game of endurance, so this is why this isn't the way I'd go about it if I were to start again.
Instead, I would spend more time reinventing the wheel with the best free tools I can find out there, and design it so that I can reuse the same one in every project to speed up the development process.
As I already wrote, a product can really be broken down into 6 modular parts: a static website generator (used for blogs, documentation, and other common static pages like FAQ and Service Terms), a CRUD generator (to quickly release new full-stack feature skeletons), and the four main SAAS components (emailing, text editing, authentication/authorization, payment/invoicing).
All of those parts can be made for free, either by using pay-per-use services (Stripe), web frameworks (I'm using Symfony Security for auth), or open source libraries (DraftJS for the text editors).
I really believe it's a great long-term investment to spend some time building those. You'll not only have the ability to customize every aspect of your product, but also no service lock-in and an extremely low burn rate.
More importantly, if you're like me and love the act of making products itself, you'll probably have many product ideas to implement. Having your own product machine will give you the edge to increase your time-to-market.


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Train #12 is Here!
Train arrived in Edmonton from BombardierRail's Kingston (Ontario) facility where it was safely assembled while the site adhered to the COVID-19 public health guidelinesRead More
6th Cable Stays Installed!
The 6th cable stays were successfully installed on the Tawatinâ bridge! One left to go.Read More
VIDEO: Installation of the Kâhasinîskâk Bridge
Check out the time-lapse installation of the Kâhasinîskâk pedestrian bridge installation over Connors Road. Video by City of Edmonton.Read More
VIDEO: LRT Bridge Span Installation Over Whitemud Drive
Check out the video!Read More
VIDEO: 2019 Year-In-Review
Check out the 2019 construction season highlights.Read More


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Galway SFC QF: Salthill-Knocknacarra advance
Galway SFC Quarter-Final
By Cian O'Connell at Tuam Stadium
Gearoid Armstrong fisted over a last gasp winning point as Salthill-Knocknacarra advanced to the penultimate stage of the Galway SFC.
A tense Tuam Stadium encounter was ultimately decided by Armstrong's late intervention ensuring Anthony Finnerty's charges prevailed.
Salthill shaded the opening period, but an opportunistic goal on the stroke of half-time from Danny Cummins edged Claregalway 1-4 to 0-6 ahead.
Robert Finnerty replied with a Salthill-Knocknacarra point to leave the teams deadlocked at the break and the issue was delicately poised.
When the action recommenced Sean Moran, Conor Campbell, and Mark Rohan fired over points for a determined Claregalway outfit.
Salthill-Knocknacarra, though, remained cool with substitute Paddy Culhane and Finnerty sharp in attack.
In the 57th minute Finnerty guided Salthill-Knocknacarra back into the lead, but Claregalway's Conor Flaherty responded with a delightful effort.
Extra-time appeared imminent, but Salthill-Knocknaccara crafted one final chance which was finished by Armstrong.
Scorers for Salthill-Knocknacarra: Robert Finnerty 0-6 (4fs), Gearoid Armstrong 0-3, Paddy Culhane (1f) and Ruairi Lavelle (2 45s) 0-2 each.
Scorers for Claregalway: Danny Cummins 1-1, Mark Rohan and Sean Moran (1f) 0-2 each, Conor Kelly, Conor Flaherty, Conor Campbell, and Barry Goldrick (f) 0-1 each.
SALTHILL-KNOCKNACARRA: Ruairi Lavelle; Eoin McFadden, David Connaughton, Ruaidhri McTiernan; Gearoid Armstrong, Finian Hanley, William Finnerty; John Meagher, Rob Butler; Cathal Sweeney, Seanie O'Leidhinn, Robert Walzer; Marcus MacDonnacha, Robert Finnerty, Eoghan Tinney.
Subs: Tom Considine for McTiernan (HT), Paddy Culhane for Walzer (36), Gavin Duffy for Considine (45), Aidan Halloran for Tinney (59).
CLAREGALWAY: Brian O'Donoghue; Matthew Kilgannon, Dylan Buckley, Stephen Cunniffe; Conor Campbell, Peter Divilly, Dara Whelan; Darren Hennessy, Conor Costello; Conor Kelly, Sean Moran, Brion Connolly; Mark Rohan, Barry Goldrick, Danny Cummins.
Subs: Jack Glynn for Divilly (HT), Jason Reilly for Hennessy (39), Conor Flaherty for Kelly (55).
REFEREE: Gerald Anthony Lohan.


text:
View All Calendars is the default. Choose Select a Calendar to view a specific calendar. Subscribe to calendar notifications by clicking on the Notify Me button, and you will automatically be alerted about the latest events in our community.
September 24, 2019, 3:30 PM - 4:30 PM @ Deer Park Public Library
Children may choose from two fabulous Apple & Pumpkin themed Fall crafts presented for children 5-8 years old and children 9-12 years old. All materials are provided free of cost.


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03 Apr SARS-CoV-2: Why is this coronavirus potent?
Why is SARS-CoV-2 more potent than other coronaviruses?
Of the 7 coronaviruses known to infect humans, only 3 of them, SARS-CoV-2, MERS-CoV and SARS-CoV cause severe disease in humans. SARS-CoV-2 infections spread rapidly and are more fatal. What is the difference between them?
- Affinity of RBD for ACE2: The receptor-binding domain (RBD) of SARS-CoV-2 has a higher affinity for ACE2 than the RBDs from other coronaviruses. The higher the affinity, the more its ability to infect cells. Higher affinity may be because of a mutation in the RBD(1).
- Polybasic furin cleavage site: In SARS-CoV-1, an additional polybasic cleavage site is found at the junction of S1 and S2 which allows effective cleavage by furin. This might have an impact on its transmissibility & pathogenesis(1).
- Cytokine Profile: Cytokine profiles are often perturbed during viral infections. In individuals with SARS-CoV-2 infection, the level of inflammatory cytokines was significantly higher than normal. In addition, there was significant correlation between cytokine levels and severity of the disease(2). The severe cytokine storm is reflected in the severity of the symptoms. Find out which cytokines were affected.
OriGene has launched a comprehensive SARS-CoV-2 Tool Set to investigate the SARS-CoV-2-Human cells interaction. Learn more.
SARS-CoV-2 Tools
Also for you ♥
- Read the blog on ACE2-Receptor for COVID19 Invasion
- Take advantage of our current promotions
- Have a unique research need? Check out our custom services
- What can OriGene do for you? Find out here.
1. The proximal origin of SARS-CoV-2, Andersen et al, Nature Medicine, 2020
2. A Review of Coronavirus Disease-2019, Tanu Singhal, Indian Journal of Pediatrics, 87, 281-286 (2020)
Request FREE Quote now!


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Boys I know what you are thinking. But before you take this possible new obsession any further, let me tell you like it is. It's much too small for you, so you might as well forget it. Unfortunately the YSL Small Tote (inspired by the iconic Muse) is made specially for the ladies. When I first saw images of it online I also thought what a great bag it would make for a guy, but my bubble was burst when I visited YSL Paragon last weekend.
Still, it's a sensible solid work bag for the ladies, especially if you like its structured full leather body or need to lug around a tiny laptop/work files (it measures 30 cm across). There is even an option for personalising some part of it, though I was much too devastated there and then to ask. Retailing for SGD2040, I still like it, even if we are not meant to be together.
Image: YSL


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Okobie road tanker explosion
Accident location shown within Nigeria
|July 12, 2012
|Okobie, Nigeria
|Tanker truck explosion
|Non-fatal injuries
The Okobie road tanker explosion occurred on 12 July 2012 when a tank truck in Okobie, Nigeria, fell into a ditch, spilled its petrol contents, and subsequently exploded.[2]
The tanker attempted to avoid a collision with two cars and a bus,[3] veered into a ditch, and spilled fuel.[2] Hundreds of locals rushed to the scene to take some of the spilled petrol.[4]
About 40 minutes after the accident, the tanker exploded. The death toll was initially placed at 95,[5] including 93 people who perished instantly and two who died after being brought to hospital.[3] The death toll was later revised to 121 after more bodies were recovered from neighboring villages where they had been taken by their relatives.[1] The number of injured was at least 75, although the actual number was likely higher as some were treated by relatives or at private clinics.[1] Some 34 motorcycle taxis were destroyed.[3] The drivers of the motorcycles, known as Okada in Nigeria, came to scoop up spilled fuel for their vehicles after learning of the accident and became victims of the explosion.[5]
In separate statements, the Nigerian National Emergency Management Agency (NEMA) and the Federal Road Safety Commission of Rivers State gave the same figures for the incident.[3] The NEMA statement also said that "rescue workers from the police, road safety, fire service, civil defence and NEMA were at the scene to evacuate victims and control traffic".[3] Nigerian President Goodluck Jonathan said he was "deeply saddened by the loss of many lives" and "particularly distraught by the fact that, once again, so many Nigerian lives have been lost in an avoidable fuel fire disaster".[4] Jonathan was referring to two previous incidents: one in March 2012 killing six people and one in April 2011 killing 50.[3]
See also
- ↑ 1.0 1.1 1.2 1.3 "Death toll rises to 121 after fuel tanker explosion in Nigeria". BNO News. 15 July 2012. Retrieved 16 July 2012.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- ↑ 2.0 2.1 Reuters in the Niger Delta (2012-03-12). "Niger delta petrol tanker crash kills 92". The Guardian. Retrieved 2012-03-12.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 "Nigeria oil tanker fire kills at least 95". Agence France-Presse. NDTV. 12 July 2012. Retrieved 13 July 2012.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- ↑ 4.0 4.1 Yinka Ibukun (13 July 2012). "Oil truck explosion kills at least 95 in southern Nigeria". Associated Press. Pittsburgh Post-Gazette. Retrieved 13 July 2012.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
- ↑ 5.0 5.1 "Nigerians die in fuel tanker fire". BBC News Online. BBC. 2012-03-12. Retrieved 2012-03-12.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>


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Canon Europe On the EOS R & RF 24-105mm F4-7.1 IS STM Lens, Shows "How to Achieve Centre Focus Macro Photographs" from a guide with how to centre focus for macro photography find out the functions with the Technology, On the RF 24-105mm F4-7.1 IS STM Lens.
From Canon Europe:
"We took the new Canon RF 24-105mm F4-7.1 IS STM lens and have put together a quick video guide for you on how to achieve centre focus macro photographs."
"As part of the EOS R range, the versatile, all-purpose 24-105mm lens with in-built optical Image Stabilizer that keeps your images and movies steady and helps you get those nice closeup shots. Have fun!"


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[ kleen ]
/ klin /
adjective, clean·er, clean·est.
free from dirt; unsoiled; unstained: She bathed and put on a clean dress.
free from foreign or extraneous matter: clean sand.
free from pollution; unadulterated; pure: clean air; clean water.
habitually free of dirt: Cats are considered clean animals.
characterized by a fresh, wholesome quality: the clean smell of pine.
free from all writing or marking: a clean sheet of paper.
having few or no corrections; easily readable: The publisher demanded clean proofs from the printer.
free from roughness or irregularity: He made a clean cut with a razor.
not ornate; gracefully spare; forceful and simple; trim; streamlined: a clean literary style; the clean lines of a ship.
complete; unqualified: a clean break with tradition.
morally pure; innocent; upright; honorable: to lead a clean life.
showing good sportsmanship; fair: a clean fighter.
inoffensive in language or content; without obscenity.
(of a document, record, etc.) bearing no marks of discreditable or unlawful conduct; listing no offenses: a clean driver's license.
- innocent of any crime.
- not having a criminal record.
- carrying or containing no evidence of unlawful activity or intent, as controlled substances, unlicensed weapons, or contraband: The agents searched the car for drugs, but it was clean.
- not using narcotics.
(of a nuclear weapon) producing little or no radioactive fallout.
not radioactive.
(of a document or financial instrument) free from qualifications or restrictions: a clean bill of lading.
free from defects or flaws: a clean diamond.
free from encumbrances or obstructions.
neatly or evenly made or proportioned; shapely; trim: a clean profile.
made without any unanticipated difficulty or interference: The bank robbers made a clean getaway.
Chiefly Biblical. having no physical or moral blemish or carrying no taboo so as to make impure according to the laws, especially the dietary or ceremonial laws: a clean animal; clean persons.
dexterously performed; adroit: a clean serve in tennis.
(of a jump over an obstacle) made without touching the obstacle.
Slang. having no direct associations, business interests, etc., that could prejudice one's official acts or decisions: The new governor is clean because he's sold his construction business and doesn't owe political favors to anyone.
Slang. without money or funds.
(of wine) having a taste that is unusually refreshing and smooth.
Nautical. (of an anchorage, harbor, etc.) free of obstructions or hazards (opposed to foul).
(of the legs of a horse) free from injury or blemish, as capped hocks, splints, or scars.
Foreign Exchange. (of currency floats) not influenced by exchange-rate manipulation (opposed to dirty).
adverb, clean·er, clean·est.
in a clean manner; cleanly: Nobody wants to box with him because he doesn't fight clean.
so as to be clean: This shirt will never wash clean.
Informal. wholly; completely; quite: The sharp carving knife sliced clean through the roast. In a year, he had gone clean through his inheritance.
verb (used with object)
to make clean: Clean those dirty shoes.
to remove or consume the contents of; empty; clear: She sat down to dinner ravenous and within five minutes had cleaned her plate.
to dry-clean.
to remove the entrails and other inedible parts from (poultry, fish, etc.); dress.
Slang. to take away or win all or almost all the money or possessions of (often followed by out): The cards were marked and I got cleaned.
Metallurgy. to remove the seams from (a casting) by filing or grinding.
Philately. to delete intentionally the cancellation from (a postage or revenue stamp).
verb (used without object)
to perform or undergo a process of cleaning: This kind of fabric cleans easily. Detergents clean better than most soaps.
to get rid of dirt, soil, etc. (often followed by up): to spend the morning cleaning.
Verb Phrases
clean out,
- to empty in order to straighten or clean.
- to use up; exhaust: He had cleaned out his savings.
- Informal. to drive out by force.
- to empty or rid (a place) of occupants, contents, etc.: Eager customers cleaned out the store on the first day of the sale. The thief cleaned out the safe.
- Slang. to cause to lose all or almost all one's money or possessions.
clean up,
- to wash or tidy up.
- to rid of undesirable persons or features: They cleaned up the local bars.
- to put an end to; finish: to clean up yesterday's chores.
- Informal. to make a large profit: They cleaned up in the stock market.
This windfall of words will make you rich with knowledge. Mine your memory on the words from July 27 to August 2!
Question 1 of 7
What does "scattergood" mean?
a person who acts as though he or she knows everything and who dismisses the opinions, comments, or suggestions of others.
a person who spends possessions or money extravagantly or wastefully; spendthrift.
a well-intentioned but naive and often ineffectual social or political reformer.TAKE THE QUIZ TO FIND OUT
Idioms for clean
- (of a sail or sails) filled with wind; rap full.
- (of a sailing vessel) with all sails full of wind; rap full.
clean full, Nautical.
clean house, to wipe out corruption, inefficiency, etc., as in an organization: It's time for the city government to clean house.
clean up one's act. act(def 29).
come clean, Slang. to tell the truth, especially to admit one's guilt.
Origin of clean
before 900; Middle English clene, Old English clǣne pure, clear, cognate with Old High German kleini (German klein small)
SYNONYMS FOR clean
1 neat, immaculate.
7 legible.
19 unblemished, flawless.
34 entirely, thoroughly.
ANTONYMS FOR clean
1 dirty.
17 contaminated, radioactive.
35 soil.
synonym study for clean
1. Clean, clear, pure refer to freedom from soiling, flaw, stain, or mixture. Clean refers especially to freedom from soiling: a clean shirt. Clear refers particularly to freedom from flaw or blemish: a clear pane of glass. Pure refers especially to freedom from mixture or stain: a pure metal; not diluted but pure and full strength. 35. Clean, cleanse refer to removing dirt or impurities. To clean is the general word with no implication of method or means: to clean windows, a kitchen, streets. Cleanse is especially used of thorough cleaning by chemical or other technical process; figuratively it applies to moral or spiritual purification: to cleanse parts of machinery; to cleanse one's soul of guilt.
OTHER WORDS FROM clean
clean·ness, nounhalf-cleaned, adjectiveo·ver·clean, adjectiveo·ver·clean·ly, adverb
o·ver·clean·ness, nounpre·clean, verb (used with object)re·clean, verb (used with object)su·per·clean, adjectiveun·cleaned, adjective
WORDS THAT MAY BE CONFUSED WITH cleanclean cleanse (see synonym study at the current entry)cleanliness cleanness
Words nearby clean
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2020
British Dictionary definitions for clean out (1 of 2)
clean out
verb (tr, adverb)
(foll by of or from) to remove (something) (from or away from)
slang to leave (someone) with no moneygambling had cleaned him out
informal to exhaust (stocks, goods, etc) completely
British Dictionary definitions for clean out (2 of 2)
/ (kliːn) /
without dirt or other impurities; unsoiled
without anything in it or on ita clean page
recently washed; fresh
without extraneous or foreign materials
without defect, difficulties, or problemsa clean test flight
- (of a nuclear weapon) producing little or no radioactive fallout or contamination
- uncontaminatedCompare dirty (def. 11)
(of a wound, etc) having no pus or other sign of infection
pure; morally sound
without objectionable language or obscenitya clean joke
(of printer's proofs, etc) relatively free from errors; easily readableclean copy
thorough or completea clean break
dexterous or adroita clean throw
sport played fairly and without fouls
simple in designa ship's clean lines
aeronautics causing little turbulence; streamlined
(of an aircraft) having no projections, such as rockets, flaps, etc, into the airstream
honourable or respectable
habitually neat
(esp of a driving licence) showing or having no record of offences
- innocent; not guilty
- not carrying illegal drugs, weapons, etc
nautical (of a vessel)
- having its bottom clean
- having a satisfactory bill of health
Old Testament
- (of persons) free from ceremonial defilement
- (of animals, birds, and fish) lawful to eat
New Testament morally and spiritually pure
clean sweep See sweep (def. 33)
to make or become free of dirt, filth, etcthe stove cleans easily
(tr) to remove in making cleanto clean marks off the wall
(tr) to prepare (fish, poultry, etc) for cookingto clean a chicken
in a clean way; cleanly
not standard (intensifier)clean forgotten; clean dead
clean bowled cricket bowled by a ball that breaks the wicket without hitting the batsman or his bat
come clean informal to make a revelation or confession
the act or an instance of cleaninghe gave his shoes a clean
Derived forms of cleancleanable, adjectivecleanness, noun
Word Origin for clean
Old English clǣne; related to Old Frisian klēne small, neat, Old High German kleini
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
Idioms and Phrases with clean out (1 of 2)
clean out
See clean up, def. 1.
Empty something of its contents, leave bare. For example, The crows cleaned out the whole field of corn, or At the shop's first sale the customers cleaned out the entire stock of shoes. [Mid-1800s]
Deprive of money or other material resources. This usage originated in gambling, where it signified losing one's last stake. Charles Dickens had it in Oliver Twist (1838): "He has cleaned me out, but I can go and earn some more." [Early 1800s]
Drive out by force, as in The new CEO tried to get away with cleaning out all employees over the age of 60. [Mid-1800s]
Idioms and Phrases with clean out (2 of 2)
In addition to the idioms beginning with clean
- clean as a whistle
- clean bill of health
- clean breast
- clean hands, have
- clean house
- cleanliness is next to godliness
- clean out
- clean slate
- clean someone's clock
- clean sweep
- clean up
also see:
- come clean
- have a clear (clean) conscience
- keep one's nose clean
- make a clean breast of
- make a clean sweep
- new broom sweeps clean
- take to the cleaners
- wipe the slate clean
The American Heritage® Idioms Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.


text:
Water Lilies
General Information
We offer high quality, fun and motivating small group lessons and private tuition for all ages and all abilities. We welcome babies from 6 weeks old. For pre-school and school age non-swimmer, beginner and advanced beginner swimming lessons classes are run with just 4 children in a class. Whatever your ability or age we can help you learn this life-saving skill and to enjoy being active and having fun in the water!
We are delighted to operate from 10 private, heated pools across Norfolk and Suffolk.
All Water Lilies Swimming School lessons and sessions must be pre-booked through the Water Lilies Swimming School Office.
Please contact us for dates, times and availability, tel: 01379 740489 or email: email@example.com
Bungay Swimming Pool Oaklands Leisure Pool, Flixton Road, Bungay, Suffolk. NR35 1PD
Fressingfield Swimming Pool Fressingfield, Eye, Suffolk. IP21 5QQ
Redlingfield Swimming Pool Wash Farm Barn, Redlingfield, Suffolk. IP23 7QP
Burgh St Peter Swimming Pool Waveney River Centre Pool, Staithe Road, Burgh St Peter, Beccles, Suffolk.NR34 0BT
Ubbeston Swimming Pool The Low Road, Ubbeston, near Laxfield, Halesworth, Suffolk. IP19 0EY
Special Offers
More Info
- categories
- Classes & Activities
- Swimming Lessons
It is your responsibility to verify availabilities, opening times, and all relevant details of businesses and events shown on this website.


text:
A two-member judge bench comprising Justices Janak de Silva and Nishshanka Bandula Karunaratne had issued the order when the case was taken up today (Oct 21).
The Centre for Enviornmental Justice had filed the petition naming the Central Enviornmental Authority (CEA), Police Chief Chandana Wickramaratne and the Attorney General as respondents.
The petitioners argued that the CEA had failed to implement laws against visual pollution caused by banners and hoardings, despite preparing the laws in 2014.
They pointed out that there is a "grave necessity" to implement these laws in line with the upcoming elections. Accordingly, the petitioners sought a court order instructing the CEA, to implement these laws in due course.
(Sunday Times)


text:
Interested in Learning More?
Please complete the form below to express interest in having your student enroll in Aurora Community School.
Note: In order to access the form, you will need to click on the flag that represents your preferred language. Please contact the school at firstname.lastname@example.com, if you need these forms translated into a different language.
Completing this form DOES NOT obligate the student to attend ACS, nor does it guarantee admission.
After completing this form, we will follow-up to schedule a time to meet with you in person.
We are registering incoming Kindergarten, 1st, 2nd, 3rd, 6th and 7th graders! Please complete this form to express your interest, and we will reach back out, regarding next steps.


text:
A popular Indian takeaway has scooped two prestigious awards.
Balti Night, in Braintree, was crowned Indian Takeaway Restaurant of the Year in Essex at the Global Hospitality Awards.
Balti Night, on Manor Street, has been one of Braintree's most popular takeaways for 30 years.
The Global Hospitality awards are presented by LUXlife Magazine and recognise firms whose work is vital to the industry. A spokesperson from the awards said: "Balti Night Braintree, like all our victors, has demonstrated excellence and commitment to the hospitality industry and we shall be proud to help them promote that to the best of their advantage."
Balti Night was also recognised as the best takeaway by the 2020 Good Food Awards which are designed to recognised hard-working teams.


text:
1 Pair Tennis Racket Handle Controller Tennis Racquet Somatosensory Game Sports for Nintendo Switch Joy-con Grips,F1757
- Description
- Additional information
Perfectly compatible with Joy-Con controller, easy and simple to use, very convenient. Enjoy the happiness of playing tennis without going outside, give you the real feeling of playing tennis game.
The product used in somatosensory mode, bring you the reality experience.
Include 2pcs tennis racket and 2pcs hand straps
Use high quality ABS material
Perfectly compatible with Joy Con controller
Lightweight, comfortable to hold.
Easy to install and convenient to remove.
Product Name: Tennis Racket
Material: ABS
Item Size: 33*12.5*2.4cm / 13*4.9*0.9in (for each)
Item Weight: 70g / 2.5oz
Package Size: 33*13*4cm / 13*5.1*1.6in
Package Weight: 203g / 7.2in
Color: Red+Blue
Note: The handle of Switch is not included, just a pair of simple tennis racket.
Package List:
2 * Tennis Rackets
2 * Wristbands
Additional information
|213.8 g
As Picture Show


text:
I lost someone very close to me due to suicide. I didn't think I could handle it, and I was going through a very atheistic period in my life, so I didn't feel there was hope of ever seeing them again. The whole thing was devastating to me and I didn't see how I could go on.
However, that person started leaving little unmistakable signs that they still exist, for me and other family members. It helped us all to get through it. I went from being an atheist to agnostic. I don't have many answers but I know there is more than this life.
It is my hope that you get whatever comfort you and your family needs.


text:
Thyroid disorders have emerged as one of the most common immune-related adverse events associated with anti–PD-1 monotherapy or combination anti–PD-1 and anti–CTLA-4 therapy. This study characterizes and compares the evolution of monotherapy and combination therapy-related thyroid disorders. We analyzed the dynamic evolution of thyroid disorders in 45 patients who developed thyroid disorders following treatment with either anti–PD-1 monotherapy or anti–PD-1 and anti–CTLA-4 combination therapy. The patients presented with thyrotoxicosis or hypothyroidism as the initial presentation of their thyroid disorder. Thyrotoxicosis as the initial presentation occurred in the majority of patients (93% and 56% of the patients receiving combination therapy and monotherapy, respectively). The onset pattern of the thyroid disorder was significantly different between the two groups (P = 0.01). Subsequently, 76% and 90% of the patients with thyrotoxicosis evolved to develop hypothyroidism in the combination and monotherapy groups, respectively. In the combination therapy and monotherapy groups, the median times to onset of thyrotoxicosis and hypothyroidism after first treatment were 21 and 63 days, and 31 and 68 days, respectively. The median time for transition from thyrotoxicosis to hypothyroidism was 42 days in both groups. Our study demonstrates that most thyroid disorders induced by either anti–PD-1 or combination anti–PD-1 and anti–CTLA-4 therapy are thyroiditis. The time to onset of thyrotoxicosis after treatment initiation and evolution of thyrotoxicosis to hypothyroidism was short, emphasizing the importance of close monitoring of thyroid function in these patients. Cancer Immunol Res; 5(12); 1133–40. ©2017 AACR.
Immune checkpoints are cell surface proteins expressed on T lymphocytes and other immune cells (1). Inhibition of immune checkpoints has shown antitumor efficacy across a spectrum of solid and hematologic malignancies in clinical studies (2–5). A common feature of immune checkpoint inhibition is that it may also lead to immune-related adverse events (irAE; refs. 6–8).
Endocrinopathies, such as hypophysitis and thyroid disorders, are among the most common irAEs (9–11). Hypophysitis is more commonly associated with CTLA-4 inhibition, whereas thyroid disorders are more common in patients receiving anti–PD-1 therapy (2, 7, 12, 13). Although the clinical manifestations of immune checkpoint inhibition-related hypophysitis have been well described in several large case series (9–11, 14), few studies have characterized the nature and progression of immune checkpoint inhibition-related thyroid disorders. Clinical trials have found that the incidence of thyroid disorders is high in anti–PD-1 treatment, 5% to 9.5% with pembrolizumab treatment (3, 15) and 8.6% with nivolumab treatment (16). A single institution retrospective review found an incidence of hypophysitis of 8% and of primary hypothyroidism/thyroiditis of 6% in patients receiving ipilimumab (anti–CTLA-4) therapy (11). In the same study, the incidence of thyroid disorders was higher (22%) with combination CTLA-4 and PD-1 blockade, even though the incidence of hypophysitis was 9%, similar to that of anti–CTLA-4 monotherapy (11). Prompt identification and proper management of immune-mediated thyroid disorders will help to avoid severe consequences, such as life-threatening thyroid storm or myxedema coma. Here, we analyzed the dynamic evolution of thyroid disorders associated with anti–PD-1 monotherapy or combination anti–CTLA-4 and anti–PD-1 therapy in 45 patients.
Materials and Methods
Study design
Patients with immune checkpoint inhibition-related thyroid disorders were evaluated clinically in the outpatient endocrinology clinic of Brigham and Women's Hospital and received continued longitudinal clinical care. This cohort analysis was performed retrospectively by collecting relevant data from chart reviews with removal of individual identifiers. The period for this study was from December 21, 2010 to May 9, 2016. Institutional Review Board approval was obtained for the study. We analyzed the type of checkpoint inhibition therapy, initial presentations of the thyroid disorder, time to onset after treatment initiation, and time for evolution from thyrotoxicosis to hypothyroidism. The patients received either combination therapy or monotherapy. Combination therapy was comprised of ipilimumab (3 mg/kg) and nivolumab (1 mg/kg) every 3 weeks for up to 4 doses followed by nivolumab monotherapy (3 mg/kg) every 2 weeks. Patients on monotherapy received either pembrolizumab (2 mg/kg every 3 weeks, n = 6; 10 mg/kg every 3 weeks, n = 3; 200 mg/infusion every 2–3 weeks, n = 5) or nivolumab (3 mg/kg every 2 weeks, n = 4).
Definition of thyrotoxicosis and hypothyroidism
Thyrotoxicosis was diagnosed based on low thyrotropin (TSH) in conjunction with elevation of at least one of three thyroid hormones: total thyroxine (T4), free T4, or free triiodothyronine (FT3). We use the term thyrotoxicosis rather than hyperthyroidism in this study because hyperthyroidism is defined as overproduction of thyroid hormone by the thyroid gland, as occurs in Grave's disease, toxic nodular goiter, or TSH-driven hyperthyroidism, whereas thyrotoxicosis is defined as any cause of thyroid hormone excess. Indeed, previous studies have suggested that thyroiditis is the most common type of immune checkpoint blockade-related thyroid disorder (11, 17). Hypothyroidism was diagnosed based on an elevated TSH with a low or normal total or free T4 and/or FT3.
Definition of times to onset
Thyroid function tests were performed before each immune checkpoint inhibitor treatment, which was given every 2 to 3 weeks. Time to onset of thyrotoxicosis was defined as the number of days between the administration of the first dose of nivolumab or pembrolizumab in patients receiving monotherapy, or the first dose of ipilimumab and nivolumab in patients receiving combination therapy, and the date of the first biochemical documentation of thyrotoxicosis. Time from the onset of thyrotoxicosis to the onset of hypothyroidism was defined as the number of days between the initial biochemical documentation of thyrotoxicosis and the first biochemical documentation of hypothyroidism. Time to onset of hypothyroidism was defined as the number of days between the administration of the first dose of nivolumab or pembrolizumab in patients receiving monotherapy, or the first dose of ipilimumab and nivolumab in those receiving combination therapy, and the date of the first biochemical documentation of hypothyroidism.
Statistical analysis
Comparisons between monotherapy and combination therapy were analyzed using Fisher exact tests for categorical characteristics or exact Wilcoxon rank-sum tests for characteristics measured on a continuous scale. Presentation of thyroid disorders was divided into three groups: hypothyroidism as initial presentation (hypothyroidism only), thyrotoxicosis alone, or thyrotoxicosis followed by hypothyroidism.
Times to onset of thyrotoxicosis or hypothyroidism were each classified in 21-day increments for patients who developed the respective conditions. The pooled data in each group were analyzed to calculate the median time to onset of thyrotoxicosis, hypothyroidism, as well as the median conversion time from thyrotoxicosis to hypothyroidism. Statistical significance is defined as P < 0.05. All statistical analyses were performed using SAS 9.4 (SAS Institute Inc.) and GraphPad Prism 7 (GraphPad Software).
Demographic data
A total of 45 patients who developed thyroid disorders after either anti–PD-1 monotherapy (pembrolizumab or nivolumab) or combination therapy of anti–CTLA-4 (ipilimumab) and anti–PD-1 (nivolumab) were assessed. Among these 45 patients, 18 patients received anti–PD-1 monotherapy (nivolumab: 4/18; pembrolizumab: 14/18). The other 27 patients received anti–PD-1 (nivolumab) and anti–CTLA-4 (ipilimumab) combination therapy. The demographic data are summarized in Tables 1 and 2. Two-thirds of the patients were female in this cohort study. Although a previous study has shown a higher incidence of anti-PD-1–related thyroid disorders in females (15), we did not make the same statement due to the lack of data for the total number of patients treated with checkpoint inhibitors. The incidence of thyroid disorders was not the focus of this study. Rather, characterization of the nature and time course of the thyroid disorders was the focus. Patients with melanoma comprised 64% of the analyzed patients, followed by patients with breast cancer (11%). Patients with malignancies across the spectrum of solid cancers were also included in the analysis (Tables 1 and 2). Treatment was discontinued in two combination therapy patients due to the development of autoimmune hepatitis and/or colitis.
The median age was 58 years in the combination therapy group and 55 years in the monotherapy group. Differences in age between the two groups were not statistically significant (P = 0.69). All patients, except one, had normal baseline thyroid function tests. The patient without normal baseline thyroid function tests received combination therapy and had no history of a thyroid disorder prior to receiving immunotherapy.
Positive TPO (thyroid peroxidase) tests after treatment were found in 2 of the 6 patients tested who received combination therapy and in 4 of the 5 patients tested who received monotherapy. Thyroid-stimulating immunoglobulins were not detected in the seven patients tested (5 in combination treatment and 2 in monotherapy group). Two patients receiving combination therapy had thyroid uptake tests during the thyrotoxicosis phase. Both had low uptake, but one patient had received iodine treatment for her thyrotoxicosis prior to the uptake test. Both patients developed hypothyroidism within one month.
Conversion of thyrotoxicosis to hypothyroidism
In this study, the patients presented initially with either thyrotoxicosis or hypothyroidism. While thyrotoxicosis was frequently followed by hypothyroidism, no case of hypothyroidism was followed by thyrotoxicosis. We calculated the percentage of patients with hypothyroidism only, thyrotoxicosis only, or thyrotoxicosis followed by hypothyroidism. Only 22% (10/45) of patients presented with hypothyroidism as the initial presentation. The remaining 78% (35/45) of patients manifested initially with thyrotoxicosis (thyrotoxicosis only or thyrotoxicosis followed by hypothyroidism; Fig. 1). Among the patients with thyrotoxicosis, 80% (28/35) subsequently developed hypothyroidism. The percentage of patients with thyrotoxicosis as the initial presentation was significantly higher in the combination therapy group, 93% (25/27), than in the monotherapy group, 56% (10/18; Fig. 1; P = 0.01).
The most common symptoms in patients with thyrotoxicosis were weight loss and tachycardia. Two patients reported neck pain. Among the patients with recorded weight, 90% (20/22) of those receiving combination therapy and 89% (8/9) on monotherapy had weight loss. Among the patients with recorded heart rate, 38% (8/21) receiving combination therapy and 29% (5/17) on monotherapy had tachycardia (heart rate > 90 bpm).
The most common symptoms in patients who presented with hypothyroidism were fatigue and weight gain. Among the patients with recorded weight, 89% (16/18) in the combination therapy group and 80% (12/15) in the monotherapy group had weight gain. Rarely, patients may present with severe thyrotoxicosis. Two patients in this study who received combination therapy presented with fever, heart rate > 130 beats per minute, and weakness. Among patients who initially presented with thyrotoxicosis, 76% (19/25) and 90% (9/10) in the combination therapy and monotherapy groups, respectively, subsequently developed hypothyroidism (Fig. 1) during this study period.
Time to onset of thyrotoxicosis is short in both treatment groups
To evaluate the timing of onset in new cases of thyrotoxicosis or hypothyroidism, we classified the time to onset of thyroid disorders by two different methods: (i) time to onset of new cases of thyrotoxicosis (Fig. 2A) and hypothyroidism (Fig. 3A) in 21-day intervals (Fig. 2A and Fig. 3A) and (ii) median time to onset of thyrotoxicosis (Fig. 2B) and hypothyroidism (Fig. 3B) in the combination therapy and monotherapy groups.
In the combination therapy group, 83% of the patients with thyrotoxicosis presented with biochemical evidence of this disorder within 21 days after the first immune checkpoint inhibition treatment (Fig. 2A), whereas the remaining 17% of thyrotoxicosis cases occurred within 84 days (Fig. 2A). Conversely, in the monotherapy group, 30% of patients developed thyrotoxicosis within 21 days, whereas 10% developed thyrotoxicosis more than 84 days after the first treatment (Fig. 2A). For patients with thyrotoxicosis, median onset times were 21 days (range, 7–64 days) and 47 days (range, 14–447 days) in the combination therapy and monotherapy groups, respectively, and were significantly shorter with combination therapy (exact Wilcoxon rank-sum test, P = 0.006).
Hypothyroidism did not develop within 21 days of the first immune checkpoint inhibition treatment in either group of patients. For patients who developed hypothyroidism, the onset times were comparable between combination therapy and monotherapy groups (Fig. 3A). The median time to onset of hypothyroidism was 63 (range, 24–141 days) and 70 (range, 27–475 days) in the combination and monotherapy groups, respectively (exact Wilcoxon rank-sum test, P = 0.09). We analyzed the median time to onset of hypothyroidism in subgroups of the patients. The median times to onset of hypothyroidism in the combination therapy group were 63 days (thyrotoxicosis followed by hypothyroidism; range, 35–141 days) and 26 days (hypothyroidism only; range, 24–28 days), whereas the monotherapy times were 84 days (thyrotoxicosis followed by hypothyroidism; range, 63–475 days) and 56 days (hypothyroidism only; range, 27–159 days; Fig. 3B). Although the data suggest that the median time to onset of hypothyroidism was shorter if hypothyroidism was the initial presentation in both monotherapy and combination therapy groups, the differences in onset times did not reach significance.
Dynamic evolution of thyroid disorders
Because most thyrotoxicosis cases progressed to hypothyroidism, we evaluated the conversion time from thyrotoxicosis to hypothyroidism. The median time from onset of thyrotoxicosis to onset of hypothyroidism was 42 days (range, 14–169) and was not significantly different between the combination therapy and monotherapy groups, with the same median time of 42 days in both groups and similar ranges (combination therapy, 14–77 days and monotherapy, 21–169 days; Fig. 4). During our study period, none of the patients had resolution of hypothyroidism, whether they developed hypothyroidism as their primary presentation or following thyrotoxicosis. Seven patients (6 combination therapy and 1 monotherapy) did not develop hypothyroidism after the onset of thyrotoxicosis during follow-up from 1 week to 12 months. One patient presented with thyrotoxicosis followed by euthyroidism for 2 months, with subsequent biochemical evidence of subclinical hyperthyroidism that persisted for more than 8 months until death. No autoantibody testing or thyroid uptake studies were performed in this patient. Therefore, whether the patient developed mild Grave disease or had thyroiditis with a prolonged phase of thyrotoxicosis is unclear. One patient who received monotherapy had preexisting hypothyroidism and was on stable levothyroxine replacement. He developed transient thyrotoxicosis after monotherapy and became euthyroid with continued replacement of levothyroxine. In the combination therapy group, one patient was lost during the follow-up period. Three patients remained euthyroid for 8 to 12 months; 1 patient, as described above, remained hyperthyroid for more than 8 months; and 1 patient had follow-up for less than 1 week.
Thyroid disorders have emerged as one of the most common adverse events associated with anti–PD-1 monotherapy and with combination anti–PD-1 and anti–CTLA-4 therapy (7, 12, 16–18). Although two studies reported 10 to 17 patients with anti-PD-1–related thyroid disorders and described them as painless thyroiditis or inflammatory thyroiditis (17, 19), no studies characterizing the nature and time course of immune checkpoint blockade-related thyroid disorders have been performed.
In this cohort study, we find that the initial presentation of thyroid dysfunction in those receiving combination therapy was predominantly thyrotoxicosis (93%). In contrast, close to half of the patients (44%) receiving anti–PD-1 monotherapy presented with hypothyroidism as their first presentation. The mechanisms underlying the different patterns of presentation of thyroid dysfunction between the two groups remain to be elucidated. With combination therapy, all patients received nivolumab as anti–PD-1 therapy, whereas 14 of 18 patients in the anti–PD-1 monotherapy group received pembrolizumab and 4 of 18 received nivolumab. We evaluated patients receiving nivolumab as anti–PD-1 monotherapy; 50% (2/4) presented with hypothyroidism as initial manifestation, which is similar to patients receiving pembrolizumab. The times to onset of hypothyroidism in these 2 patients were 27 and 84 days, respectively. In the other 2 patients receiving nivolumab monotherapy and manifesting thyrotoxicosis, the time to onset of thyrotoxicosis was 21 and 63 days, respectively.
Anti–CTLA-4 monotherapy is associated with primary thyroid disorders (4, 20). In our database, 2 of 25 patients with ipilimumab monotherapy-related hypophysitis developed primary thyroid disorders. Both patients presented with thyrotoxicosis followed by a return to a euthyroid state. Another 2 patients in our earlier report (20) receiving combination ipilimumab and bevacizumab, an angiogenesis inhibitor, displayed a similar evolution of the thyroid disorder: thyrotoxicosis followed by euthyroidism. It appears that the nature of thyroid disorders with anti–CTLA-4 monotherapy may be different from those occurring in association with anti–PD-1 monotherapy and those with combination anti–CTLA-4 and anti–PD-1 therapy.
Concomitant endocrine toxicities were not uncommon. More than one third (10/27) of patients with combination therapy-related thyroiditis had synchronous hypophysitis and secondary adrenal insufficiency. In patients with anti-PD-1–related thyroiditis, 22% (4/18) had synchronous hypophysitis and secondary adrenal insufficiency and 1 patient developed metachronous autoimmune diabetes.
Thyroid disorders associated with immune checkpoint inhibitor therapy were described as hyperthyroidism, hypothyroidism, and thyroiditis in previous reports (11, 16, 21). The findings in our study suggest that most immune checkpoint blockade-related thyroid disorders are likely thyroiditis. This conclusion is based on the findings that 80% of the patients who presented initially with thyrotoxicosis subsequently developed hypothyroidism during this study period. The time course of disease progression is consistent with thyroiditis. Hypothyroidism, as an initial presentation in the setting of autoimmunity, is thyroiditis in nature. In this study, measurement of radioiodine thyroid uptake was not routinely performed in patients with thyrotoxicosis. In fact, in our practice, after realizing that most of the thyroid disorders were consistent with thyroiditis, we seldom ordered thyroid uptake testing in order to limit costs. Frequent enhanced CT studies with concurrent iodine-based contrast exposure to monitor the cancer response decreases radioiodine uptake and makes the results of radioiodine thyroid uptake testing unreliable. We recommend thyroid uptake tests in patients with signs suggestive of Grave disease (e.g., goiter, ophthalmopathy, or persistent thyrotoxicosis) and without CT intravenous contrast exposure for at least 1 month.
We analyzed the timing of onset of thyroid disorders in 21-day increments after the first immune checkpoint inhibition treatment. We chose the time interval of 21 days because anti–PD-1 and anti–CTLA-4 therapies were given every 2 to 3 weeks. Calculation of the incidence of thyroid disorders in 21-day intervals provides not only a correlation of the pattern of onset of the thyroid disorder with time but also a correlation between the onset of the thyroid disorder and the number of treatments given. This analysis revealed that 83% and 36% of thyrotoxicosis occurred within 21 days after the first infusion with combination therapy and monotherapy, respectively, and within 84 days after the first treatment, 100% of thyrotoxicosis cases had already occurred in patients receiving combination therapy, whereas 90% of cases of thyrotoxicosis had occurred by this time in the monotherapy group. These findings suggest that close monitoring of thyroid function tests after initiating either combination therapy with anti–PD-1 and CTLA-4 or anti–PD-1 monotherapy is needed. Specifically, TSH and free T4 levels should be checked within 3 weeks after initiating therapy.
No biochemical evidence of hypothyroidism within 21 days after the first immune checkpoint inhibition treatment was observed in either group. Twenty-nine percent and 12% of hypothyroidism cases occurred more than 84 days after treatment initiation in the groups receiving monotherapy and combination therapy, respectively. The checkpoint inhibitors were not discontinued due to the development of thyroid disorders. However, immune checkpoint inhibition therapy was discontinued in 2 patients in combination group because of the development of autoimmune hepatitis and/or colitis. Discontinuation of checkpoint inhibitors did not change the thyroid outcome as no patient recovered from hypothyroidism during our study period.
A previous study of 5 patients who presented with postpartum thyroiditis showed that thyrotoxicosis developed within 1 to 6 months of delivery. In all patients, thyrotoxicosis resolved within four months. Subsequent transient hypothyroidism occurred in four of the five patients, with one developing permanent myxedema (22). Researchers have noted that painless thyroiditis is also self-limited (23). In contrast to postpartum thyroiditis and painless thyroiditis, hypothyroidism induced by anti–PD-1 monotherapy and combination anti–PD-1 and anti–CTLA-4 therapy appears to be permanent or persistent for a long duration. We have not yet seen recovery of thyroid function in any patient who developed hypothyroidism.
The earliest time of onset of thyrotoxicosis was 7 days after the first treatment in a patient receiving combination therapy. In contrast, the latest onset of thyrotoxicosis after the first treatment was 447 days, occurring in a patient receiving anti–PD-1 monotherapy. This patient had continuous exposure to anti–PD-1 treatment before the development of thyrotoxicosis. Nonetheless, as discussed above, most thyrotoxicosis occurred soon after treatment initiation. Because most patients who had an initial presentation of thyrotoxicosis subsequently developed hypothyroidism, continued monitoring of thyroid function is needed due to the differing management strategies for thyrotoxicosis and hypothyroidism.
Timely monitoring and proper management of immune checkpoint inhibition-induced thyroid disorders will help to prevent life-threatening consequences, such as thyroid storm and myxedema coma, and improve the quality of life. We recommend measuring baseline TSH and free T4 prior to initiation of immune checkpoint inhibition therapy and repeat before each infusion for at least 5 cycles. If patients develop thyrotoxicosis, they can be treated with a beta-blocker, such as propranolol (10–30 mg t.i.d. PRN for pulse > 100 bpm), for symptomatic control if they are at low risk for cardiovascular events. In patients with severe thyrotoxicosis or with high risk for cardiovascular events, such as a previous history of coronary artery disease, cardiac arrhythmia, or heart failure, treatment with high-dose corticosteroids (prednisone 1–2 mg/kg daily for 2–3 weeks) can be considered. Thyroid function should be monitored every 2 to 3 weeks, as a transition from thyrotoxicosis to hypothyroidism may occur. If thyrotoxicosis resolves and hypothyroidism develops, the beta-blocker should be discontinued and levothyroxine treatment initiated. We recommend initiating treatment with levothyroxine at 0.8 mcg/kg daily in young patients without a history of cardiovascular disease. We recommend repeating TSH and free T4 measurements one month after levothyroxine initiation for further levothyroxine dose titration. In elderly patients or patients with a history of cardiovascular disease, we recommend initiating levothyroxine treatment with a lower dose (usually 25 mcg daily) and increasing the dose slowly, as tolerated. Based on our current study and previous studies (17, 19), measurement of TPO and TSI may not be helpful in terms of clinical management. However, if a patient with thyrotoxicosis has signs of Graves' disease (i.e., a large goiter or Graves ophthalmopathy), we recommend testing TSI and performing a thyroid uptake test (if the patient has had no recent intravenous radiographic contrast administration).
In summary, immune checkpoint inhibitors display effective and durable anticancer effects across a broad spectrum of advanced malignancies. With the increasing use of this type of therapy, clinicians should be aware of irAEs including thyroid disorders in these patients. Most cases of thyroid dysfunction occurred within 12 weeks after the first treatment with either combination therapy or monotherapy, and most thyrotoxicosis converted to hypothyroidism in a relatively short period, underscoring the importance of close monitoring of thyroid function after initiation of immunotherapy. Our study provides guidance for appropriate, timely screening with thyroid function tests in this group of the patients.
Disclosure of Potential Conflicts of Interest
F.S. Hodi reports receiving a commercial research grant from Bristol-Myers Squibb to an institution and is a consultant/advisory board member for Bristol-Myers Squibb, Merck, Genentech, Novartis, Amgen, and EMD Serono. P.A. Ott is a consultant/advisory board member for Bristol-Myers Squibb, Genentech, Alexion, Novartis, Pfizer, Merck, Celldex, and CytomX. R. Haq reports receiving a commercial research grant from Bristol-Myers Squibb. S. Tolaney is a consultant/advisory board member for Merck, AstraZeneca, Eli Lilly, Novartis, Eisai, Pfizer, and NanoString. L. Min reports receiving a commercial research grant from Bristol-Myers Squibb. No potential conflicts of interest were disclosed by the other authors.
Authors' Contributions
Conception and design: H. Lee, R.S. Carroll, U.B. Kaiser, L. Min
Development of methodology: H. Lee, L. Min
Acquisition of data (provided animals, acquired and managed patients, provided facilities, etc.): H. Lee, F.S. Hodi, P.A. Ott, E.I. Buchbinder, R. Haq, S. Tolaney, K. Zhang, H. Donahue, M. Davis, K.M. Kelley, L. Min
Analysis and interpretation of data (e.g., statistical analysis, biostatistics, computational analysis): H. Lee, F.S. Hodi, A. Giobbie-Hurder, R. Barroso-Sousa, K. Zhang, U.B. Kaiser, L. Min
Writing, review, and/or revision of the manuscript: H. Lee, F.S. Hodi, P.A. Ott, E.I. Buchbinder, R. Haq, S. Tolaney, R. Barroso-Sousa, M.E. Gargano, K.M. Kelley, U.B. Kaiser, L. Min
Administrative, technical, or material support (i.e., reporting or organizing data, constructing databases): H. Lee, K. Zhang, L. Min
Study supervision: R.S. Carroll, L. Min
This research was supported by NICHD/NIH K08 HD070957 (to L. Min) and NIH R01 HD019938 and HD082314 (to U.B. Kaiser).
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Received April 19, 2017.
- Revision received August 12, 2017.
- Accepted October 19, 2017.
- ©2017 American Association for Cancer Research.


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Ryan Fuchs, Financial Planner
Yes. It can serve as an emergency fund.
Everyone should have an emergency fund that covers a minimum of 3-6 months of living expenses (and maybe more depending on your particular situation). Typically, that emergency fund should be held in a savings account or some sort of account where the money will not be subjected to the inherent uncertainties of the markets. In other words, you won't make much on the money long-term (in comparison to stocks, and probably even bonds) but you know for sure that it will be there when you need it and it will be easily accessible.
If you have your emergency fund invested in the markets, you may find yourself in a situation where you need the money and we are in a down market and there is less in the fund than you expected or need. If it is in a savings account or money market account, this uncertainty is not an issue - you know that the principal will be there.
Hope that helps and good luck.
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Sphaerococcus gelatinus (Esper) C.Agardh 1822
Publication details
Sphaerococcus gelatinus (Esper) C.Agardh 1822: (1822-1823): 270-271
Published in: Agardh, C.A. (1822). Species algarum rite cognitae, cum synonymis, differentiis specificis et descriptionibus succinctis. Volumen primum pars posterior. pp. [v-vi], 169-398. Lundae [Lund]: ex officina Berlingiana.
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Publication date: probably Oct 1822
Type species
The type species (lectotype) of the genus Sphaerococcus is Sphaerococcus coronopifolius Stackhouse.
Status of name
This name is currently regarded as a synonym of Betaphycus gelatinus (Esper) Doty ex P.C.Silva
Fucus gelatinus Esper
Type information
Type locality: Not specified (Silva, Basson & Moe 1996: 325). Lectotype: HGB (Doty 1988: 188). Notes: Doty (1995: 243) notes that the type material for this species appears to be from an abundance of frond fragments found in the Esper collections housed in the Herbarium of Institut Allgemeine Botanik, Hamburg, Gemany (HGB). A fragment (numbered 34697) in the Agardh Hebarium at the University of Lund, Sweden (LD), appears to have come from thiis Esper collection. Physically, these fragments are poorly preserved but they are accepted as isolectotypes. The specimen illustrated by Doty (1988, fig. 23A) is in the Hamburg herbarium and was selected as the lectotype and the LD specimen is an isolectotype.
No synonyms are currently included in AlgaeBase.
General environment
This is a marine species.
Detailed distribution with sources (Click to Load)
Created: 26 January 1999 by M.D. Guiry
Verified by: 23 September 2004 by M.D. Guiry
Accesses: This record has been accessed by users 650 times since it was created.
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Users are responsible for verifying the accuracy of information before use, as noted on the website Content page.
Linking to this page: http://www.algaebase.org/search/species/detail/?species_id=15919
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Cite this record as:
Guiry, M.D. & Guiry, G.M. 2020. AlgaeBase. World-wide electronic publication, National University of Ireland, Galway. http://www.algaebase.org; searched on 06 August 2020.


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Per the U.S. DoD, * Indicates a "small business" classification and ** indicates a "small disadvantaged business". NOTE: the U.S. DoD only publicly reports contracts valued at $6.5 million USD or greater.
The contract language is EXACTLY as it appears on the official U.S. DoD website (http://www.defense.gov/contracts/) unless otherwise noted.
Contractor: Oshkosh Corporation
Department: Army
Awarded: 8/8/2013
Oshkosh Corp., Oshkosh, Wis., was awarded a $76,824,064 modification (000711) to a previously awarded firm-fixed-price contract (W56HZV-09-D-0159) for the procurement of family of medium tactical vehicles. The cumulative total face value of this contract is $4,704,647,054. Fiscal 2013 procurement funds are being obligated on this award. The Army Contracting Command, Warren, Mich., is the contracting activity.
Total Contract Value: $76,824,064


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To celebrate Bronx Week, May 12-19, the Bronx Economic Development Corporation sponsored a Green Roofs Tour. Michael Nixon from the Development Office was our worthy guide, explaining the benefits of having a green roof: it keeps buildings warmer in winter, cooler in summer and it reduces energy consumption and heating/electric bills.
So off we went by Bronx Trolley – first to the Bronx Courthouse roof where stepping stones were strategically placed to prevent the plant-filled floor from being walked upon. Next we visited the rooftop of ABC Carpet & Home which gave us a wonderful view of the Bronx River.
The St. Joan of Arc Church roof was divided in two: one half had solar panels, the other half was green – created and maintained by youngsters from the Youth Ministries for Peace and Justice. This part of the roof is lush and blooming – with plants, chives and a sea of purple flowers sprouting from the chives.
At Urban Horizons, a progressive low-income apartment building, first we saw an amazing wall sculpture in the lobby: groupings of cars made from the metal of actual cars. On the roof there are separate planting trays of dirt, so residents can grow flowers, vegetables, herbs, or whatever they like.
The West Side Federation for Senior and Supportive Housing has a Grandparent Family Apartment Building. It was specifically built for grandparents who are raising their grandchildren. The green roof was designed to be thoroughly enjoyed. There are benches where residents can relax and chat with their neighbors.
Our final stop was magical. We didn't see a green roof – we saw a greenhouse in the sky. The entire roof of the Arbor House apartment building is actually a commercial greenhouse. It has 4000 square feet devoted to growing fresh produce for the Bronx community. This is the first hydroponic roof top farm in the country, owned and operated by Sky Vegetables.
Although these rooftops aren't open to the public, the Bronx is bursting at the seams with exciting things to do! To learn more, go to www.ilovethebronx.com or call 718-590-3518.
Photo credit: Karen Bell for Big Apple Greeter


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About Bark & Bounce
Bark & Bounce Bournheath is owned by Natalie and Ben Pollard who live at the adjacent Lilac Cottage. We have always owned dogs and understand not every dog can be exercised in public places for a variety of reasons.
We also understand the importance of training our dogs and we feel this is the perfect place to carry out your dog training, exclusively hired to you.
We have 2 dogs old boy Paddy (13) Sprocker and Molly (2) a beautifiul English Springer Spaniel. Natalie and Molly are currently undertaking gundog training and thoroughly enjoying it. However it has to be said that Molly remains a family pet first and a working gun dog second.
We understand that training dogs can prove to be a bit of a challenge! Here you can do so in complete confidence and safety without any distractions.
We hope you will find the facilities at Bark and Bounce particularly helpful for all your dog training needs, it's a great space to play games and bond with your dog(s).
A safe and secure environment
We are always around and want you to have a pleasant experience, you may want to hire for a group or for an afternoon have a picnic – any special requirements are considered on request.
But essentially the field is for hire to exercise your dog in a safe and secure environment and block bookings are welcome and are considerably discounted. Your induction session costs £14.50 and includes a full induction of the field. Once your membership has been approved and after your induction session you can simply book your times on the website. Its quick and simple, no hassle just enjoy your time with your 4 legged friends.


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Change Bracelets II
2 bracelets of Amazonite. Amazonite is a stone for those who want to go their own way and it supports you for all sorts of change. Crystal can clean, balance and remove negative energies. Crystal work very well with other stones as it enhances the energy of other stones.
≁Bead spacers of Sterling Silver 925.
≁Bead size: 8 mm.
≁Elastic bracelets.
Please note that natural stones can be slightly uneven and color changes may occur.
We recommend that you take care of your jewelry according to our care instructions and keep them in a jewelry bag/box.


text:
A few weeks ago Enzo and I sat down to enjoy a movie night. I had rented 2001: A Space Odyssey from Netflix.
As soon as the movie started up the apes in the opening scene had Enzo's attention. He jumped off the couch and bolted toward the screen with his roughest bark in tow. Luckily I was able to grab him before he jumped through the screen.
Tonight we were sitting around watching Animal Planet and a group of orangutans were on screen. Again Enzo went ballistic. The hair on the back of his neck stood up and he was totally focused on the screen, barking his head off.
Guess I'll have to curb the watching of ape related material in the future!
Is it the ape sound they make...you know that screechy scream?
I am guessing it is the sound they make, also.
I wonder what he would do if you rented Planet of the Apes.
...or King Kong!!!
Yeah we might have to avoid King Kong in the future! I thought it was the sound as well but the orangutans weren't really making any noise on the show last night. I guess apes just freak him out .
Puff has never reacted to animals or their sounds on TV/radio -- it's like she distinguishes between the real and just images of real. She does react to a dog bark or strange noises in the neighborhood.
Puff [YF, AKC field line (from competing HT/FT breeder) 62 lbs, dob: 8-'01]
Bess [BF, AKC bench line (from competing show breeder) 55 lbs., 1967-1981] "Poor Bess, the Wonder Dog":
Our old dog used to hear a doorbell or knock on the TV and she would bolt to the front door and start barking like mad.