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Curating Evidence¶
Evidence Items (EIDs) form the fundamental unit of the CIViC knowledgebase. EIDs derive structured clinical statements from peer reviewed publications and ASCO abstracts, which act as evidence sources for Evidence Items. The EID links back to its source. EIDs are hand-curated units of knowledge, and one evidence source may supply enough data to create multiple EIDs. EIDs are displayed throughout the CIViC application, for example as a summary (Figure 1) and as a data table row (Figure 3).
CIViC Evidence is added and curated via a moderation process that includes submitting, evaluating, accepting (or rejecting), and suggesting changes (Figure 2). CIViC Curators may add or suggest revisions to curated content at each step. Adding content involves submitting new Evidence Items or Assertions that subsequently undergo revision and review by CIViC Editors. Revision of content involves adding or revising the clinical summary and/or its associated features. Once changes are made within the CIViC database, the additions/revisions become visible directly or on a separate revision page depending on the type of submission. Curation is listed as a "submitted" (i.e., pending) until it is accepted by an Editor, who are given power to accept or reject Curator submissions. Curators may reject (but not accept) their own submissions/revisions.
It is important to note that once evidence is submitted into CIViC as a new Evidence Item, then the EID is visible to the community in the unmoderated/non-reviewed state, and these EIDs are labeled in orange (Figure 3). This enables the public to comment or create moderations on the submitted evidence. It is also important to note that orange Evidence Items may be incomplete, not accurately fit into the CIViC data model, or contain problems which the moderation process is designed to capture and fix. Once a CIViC EID has been reviewed by editors, and all revisions reviewed and accepted, then the EID is accepted by an editor, and becomes labeled green.
When an Evidence Item has a pending revision, then it is labeled with a blue exclamation mark icon (Figure 3). Note that revisions can be made to EIDs in both the Submitted/Unreviewed Status (orange) and the Accepted/Fully Reviewed Status (green).
General Evidence Item Curation Practices¶
Evidence Items should generally be prepared from primary literature rather than from review articles. It is recommended that curators use reviews to identify primary literature referenced in the review and to curate individual Evidence Items based on these cited articles. Review articles can also be used to develop Gene and Variant summaries.
When curating new evidence, the curator should review the existing evidence already curated into CIViC for that Variant to look for the following issues:
For clinical trials and case reports (Levels A, B, and C), overlapping patient populations (i.e. the same patient treatment and outcome described in multiple reports) should be avoided, or carefully noted to alert users of this nuance and avoid conclusions that mistake these studies as independent. Note also that reports describing different phases of the same patient treatment (i.e. erlotinib and subsequently afatinib), or different clinically relevant conclusions (i.e. predictive evidence and simultaneous diagnostic evidence) are independent/non-overlapping entities.
For Predisposing EIDs describing germline variants, the same patient may appear in multiple studies. Curators should be careful to note these cases by reviewing existing germline EIDs for the same variant in CIViC.
Disease stage, prior treatments, and other experimental details influencing evidence interpretation should be captured within an Evidence Item to maximize user comprehension of the underlying study and the appropriate context in which it is relevant. Such details are critical parts of clinical guidelines and can impact which clinical guidelines should be used as well as drug sensitivities (see EID1008 and EID1009).
Five types of EID exist in CIViC (Figure 4), giving structured clinical annotation to a Variant. Three types of clinical statements, Predictive/Therapeutic, Prognostic and Diagnostic, are usually associated with somatic variants, while Predisposing evidence is generally linked to germline variation. Functional studies are often performed in vitro, so associated EIDs will have the Unknown field selected for Variant Origin.
Predictive Evidence¶
Predictive/Therapeutic Evidence Items (EIDs) are structured to capture variant annotation for drug sensitivity, resistance,
Below is an example of an EID that illustrates the Predictive Evidence Type. This example describes the CLEOPATRA trial (NCT00567190), which evaluated 808 patients with HER2-positive metastatic breast cancer. These patients demonstrated significant sensitivity/response when treated with combination therapy of docetaxel, pertuzumab and trastuzumab.
Predictive Evidence Curation Practices¶
Predictive Evidence Items should include the Drug Name(s) and Drug Interaction Type (for multiple drugs).
The most current name of the Drug (excluding trade names) should be used in the Drug field to reduce duplication. The Evidence Statement should contain the drug name used in the study with the current name in brackets, when applicable.
Drug Interaction Types are required anytime more than one drug is mentioned for a given study. If multiple drug interaction types are at play (e.g., combinations and substitutes), considering separating these concepts into more than one Evidence Item.
If applicable, the Clinical Trial name and ID should be included in the Evidence Statement. Any clinical trial IDs available in PubMed for the Source linked to this Evidence Item will be automatically imported and linked to this Evidence Item when the PubMed Source is imported into CIViC.
The duration of exposure to the drug and confounding interactions (e.g., wash-out periods, previous treatment, cancer stage) should be listed.
Assigning a Clinical Significance of Sensitivity/Response can depend on factors such as response rate, which will vary significantly with disease and treatment. In some cases a response rate of 15% may represent a significant improvement, and merit a valuation of Sensitivity/Response. A general guideline for CIViC curation is to follow the author's published (and peer-reviewed) interpretations and conclusions of the results.
Extensive guidelines, use cases, and examples for curation of predictive evidence are given in Figure 7 and Table 1.
Diagnostic Evidence¶
Below is an example of an EID that illustrates the Diagnostic Evidence Type. This example describes the World Health Organization guidelines for classifying chronic myelomonocytic leukemia (CMML). Specifically, if a patient has a PCM1-JAK2 fusion or a rearrangement involving PDGFRA, PDGFRB, or FGFR1, especially in the setting of eosinophilia, the patient does not have CMML.
Diagnostic Evidence Curation Practice¶
Diagnostic Evidence Items should only be used if the variant assists in labeling the patient with a specific disease or disease subtype and should not be used to denote that the particular variant is prevalent in a specific disease.
Generally, Diagnostic Evidence Items describe variants that can help accurately diagnose a cancer type or subtype with high sensitivity and specificity, for which diagnoses may otherwise be challenging.
Diagnostic Evidence Items are very closely tied to the terms of the Disease Ontology (DO) in CIViC. The Disease Ontology works to actively generate mappings to other highly used ontologies, but the terms in the DO are generally accepted diseases which are part of medical practice. Therefore, literature proposing a novel disease type - for instance studies suggesting a novel cancer subtype defined by the presence of a specific oncogenic variant - are not generally admitted as part of the CIViC data model. Alternatively, if a curator with expertise in the field feels that the novel subtype has met with a sufficient level of acceptance, they may submit this type of Evidence Item using a non-DO term, and suggest that DO admit this term into the ontology.
Literature describing diagnostic practice guidelines (such as those of the World Health Organization) may be used in curation and submitted as A-level Evidence Items.
Literature describing small numbers of observations in patient samples of a certain variant, where the authors state that the variant may have diagnostic value, may be admitted as lower star Case Study (C-level) data. Similar literature employing larger numbers could be labeled as Clinical (B-level).
Guidelines and use cases for curation of diagnostic evidence are given in Table 1.
Prognostic Evidence¶
Below is an example of an Evidence Item that describes a Prognostic Evidence Type. This example describes a 406-patient trial whereby observation of any somatic TP53 mutation in chronic lymphoblastic leukemia conferred poor prognosis relative to wildtype TP53.
Prognostic Evidence Curation Practice¶
Prognostic Evidence Items should include the measured outcome (e.g., overall survival, complete response, partial response), number of subjects and applicable statistics.
If described in the literature, a definition of the measured outcome should be given.
Prognostic evidence is characterized by either better outcomes for patient subpopulations with the given variant, which are not specific to any particular treatment context, or worse outcomes which are not indicative of variant resistance to a specific treatment. Instead, the change in outcome should be largely correlated to the presence of the variant.
In some cases, a variant subpopulation with worse outcome may benefit from subsequent therapy targeted to that variant (e.g., HER2 amplification in breast cancer).
Guidelines, use cases, and examples for curation of prognostic evidence are given in Figure 7 and Table 1.
Curation Scenarios¶
The table below (Table 1) gives an in depth set of cases for assigning the Clinical Significance to an Evidence Item (EID) where either the "supports" or "does not support" Evidence Direction is used in combination with a Predictive/Therapeutic, Diagnostic or Prognostic Clinical Significance annotation.
Note that "Reduced Sensitivity" Clinical Significance is used to compare the variant of interest to a known, sensitizing variant. It is not used to compare the efficacy of one drug for a variant against a different drug for the same variant. In the latter case, the curator may simply make a Predictive evidence item with independently evaluates the efficacy of the drug against the variant of interest.
The "Sensitivity/Response" annotation is used to assess sensitizing variants, which are usually in the form of a primary sensitizing somatic mutation (e.g SNV, amplification, deletion, etc).
The "Resistance" annotation is used in situations where the variant of interest has been observed to induce resistance in a context where, in the absence of the variant, the system being assayed would be deemed sensitive which induce resistance to treatment (e.g. T790M mutation in cis with a background variant of EGFR L858R). In cases where a variant fails to induce sensitivity, then that variant is best annotated with "Does not Support Sensitivity".
Both Predictive and Prognostic evidence types may be obtained from the same data set in some cases. Figure 8, displayed below, gives hypothetical examples of predictive and prognostic structured annotation derived from patient data.
Predisposing Evidence Type¶
Predisposing Evidence Items are designed to capture clinical information associated with germline variants relevant for cancer. This EID type is closely associated with ACMG Codes. The general format for a predisposing EID is a summary of the reported data relevant to the variant and disease of interest, followed by an enumeration of ACMG Codes derived from the reported information, which a brief justification for the presence of each code.
Below is an example of an Evidence Item (EID5546) that describes a Predisposing Evidence Type. This example describes a study where the VHL - R167Q (c.500G>A) Variant was described in a set of patients and evidence for the PP1 ACMG-AMP criteria was documented. Hemangioblastoma and pheochromocytoma were seen in patients and are reported as Associated Phenotypes, while the Disease is Von Hippel-Lindau Disease.
Predisposing Curation Practices¶
Typically, but not always, Predisposing Evidence Items are written for rare or common germline variants. In rare circumstances, the patient can have a predisposing variant that develops as a result of a somatic mutation or mosaicism during embryogenesis that is widespread but not necessarily heritable.
ACMG-AMP evidence codes (Richards et al. 2015) (ACMG criteria) are derived from the evidence presented in the specific Source and are listed at the end of the Evidence Statement with a brief justification for each code's use. ACMG evidence codes not directly derived from Source associated with the Evidence Item (e.g. population databases for PM2) are captured at the Variant Summary or at the level of Assertion.
The above Predisposing Evidence Item (EID) lists the ACMG code PP1 as derived from the literature source, which alone results in a ACMG-AMP classification of VUS. Therefore, this Evidence Item is combined with other VHL - R167Q (c.500G>A) Evidence Items for Von Hippel Lindau Disease, in order to create CIViC Assertions, where the ACMG codes from the different Evidence Items are combined and evaluated for pathogenicity. The EID depicted here is part of Assertion number 4 (AID4), where the Evidence Items combine to pathogenic. Therefore Predisposing Evidence Items are not given Clinical Significance or Evidence Direction in isolation, and these fields are labeled N/A.
In some instances, a publication will contain relevant germline variant evidence for curation into CIViC and EID creation, but that evidence will not be sufficient to fulfill any of the ACMG criteria (especially in some cases where the gene or disease-specific criteria may be more stringent). In this case Curators should indicate this at the end of the Evidence Statement, by adding a brief statement such as "No ACMG criteria met", in order to indicate to Editors and future Users that the evidence had been analyzed for the presence of ACMG codes during the curation process.
Functional Evidence Type¶
Below is an example of an Evidence Item that describes a Functional Evidence Type. This example summarizes the impact of a novel KIAA1549-BRAF fusion event on the function of the BRAF protein. Specifically, the fusion product showed gain of function activity in cell lines relative to wildtype kinase. This activity was also demonstrated to be comparable to a known gain of function variant, BRAF V600E.
Functional Curation Practices¶
Functional Evidence Items should describe how the variant alters biological function from the reference state. This can include a change in function or lack of change in function.
Clinical Significance for Functional Evidence Types adhere to the following rules:
Gain of Function
A variant whereby new/enhanced function is conferred on the gene product
Loss of Function
A variant whereby the gene product has diminished or abolished function
Unaltered Function
A variant whereby the function of the gene product is unchanged
A variant whereby the function of the gene product is a new function relative to the wildtype function
Dominant Negative
A variant whereby the function of a wildtype allele gene product is abrogated by the gene product of the allele with the variant
A variant that cannot be precisely defined by gain-of-function, loss-of-function, or unaltered function.
Functional Evidence Items may be used to support certain ACMG codes (e.g. PM1). In these cases, the ACMG code should be listed in the Evidence Statement along with a brief justification for its inclusion.
In some cases, Functional Evidence Items may appear as supporting evidence for a Predisposing Assertion, for instance in support of a PM1 evidence code.
Curating Evidence from Clinical Trials
When curating evidence obtained from clinical trials performed with groups of patients, where data is pooled by mutation type (e.g. EGFR MUTATION), Level B clinical results may be obtained, which may report a statistically significant difference on a clinically relevant parameter such as partial response (PR) between wildtype vs. mutant patients. In addition, the publication may sometimes give outcomes on important individual patient parameters, such as variant, age, sex, best response, overall survival, etc. In these cases, this aggregate of data may be integrated into multiple Evidence Items in the following manner (The figure below is loosely based on a data set in CIViC obtained from PMID:21531810, which can be seen in CIViC on its Evidence Source page).
Statistical results may be obtained from the study to annotate a Categorical (sometimes colloquially called bucket-type) CIViC Variant, which pools together a category of sequence variants (for example EGFR MUTATION). Significantly longer progression free survival (PFS) may be observed in the mutant group (grouped under the Categorical CIViC Variant) vs. the wildtype group, when given a certain drug. In this case, this result may be reported in a CIViC Level B Evidence Item under the CIViC Categorical Variant EGFR MUTATION, with Evidence Direction and Clinical Significance "Suggests Sensitivity/Response" to the drug used.
When a sufficient level of individual patient detail is present, including the individual patient variants along with an important clinical parameter such as their best response, then this data set can be used to generate a set of CIViC Level C Evidence Items for the patients, each one associated with the respective CIViC Variant that was observed in the individual patient, along with the outcome. Note that even if the entire group showed statistically significant improvement with the Categorial Variant, this does not mean every patient did better, e.g. if a patient with variant X123Y had progressive disease as best response, then this would result in a Level C EID with Evidence Direction and Clinical Significane of "Does not support Sensitivity" for the CIViC Variant X123Y.


text:
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subset: commoncrawl


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Hello friends,
A very quick blog post today! I have gotten zero creative things done this past week because we added a new addition to our family! Continue reading
Hello friends,
A very quick blog post today! I have gotten zero creative things done this past week because we added a new addition to our family! Continue reading
Hello there,
As I was cleaning up my quilt room after all the Christmas wrapping and creating that went on on there, I happened to Continue reading
Hello again,
These past few weeks have been filled with a little bit of everything, from Continue reading
Hello friends,
I know I had promised you a fusible applique tutorial today, but this week was crazy with other things that just had to get done, so I promise to publish that post next week ;).
Instead this week I thought we could celebrate the fact Continue reading
Last Saturday my hubby and I decided to take a pretty drive down to Bedford, Pennsylvania. My destination was Mary's Quilt Shop, owned by Mary Koval, who is a quilter, quilt shop owner, and antique quilt collector, among other things! Continue reading
Hello! This week's blog post is a méli-mélo of topics! I learned this word from one of my sweet readers who explained that it is a French expression for mish-mash or hodgepodge… Continue reading
Hello again! ( I have to tell you quite honestly that writing 2 blog posts per week is hard! I am glad that we are down to one again from now on ;)….although I do hope you had fun with the Sweet Little Spring Sew-Along!
Anyway, this Saturday's post was going to be on a completely different topic…..but now you'll get to read about that next week….this week I am going to tell you about my little happy adventure…but first I will have to explain the backstory: Continue reading
Hello there,
Before you think that this will be Continue reading
Hello! Are you ready for the very last Christmas ornament of 2018?? I hope you had fun making some or all of them! If you need links to all the previous ornaments you can find those here.
Okay, let's get to the last ornament. Continue reading
Hello friends,
I am so excited to be sharing a crafty type of post for a change! There has not been a lot of crafting going on of late, but this past week I decided to pull out my one little box that holds some fairly recently acquired goodies, and start on a new project…YAY!! Continue reading


text: Add some sweetness to your snapback style with the New York Yankees "Candy Smudge" 9FIFTY cap. This cap comes in a groovy all over Candy Smudge print, with white embroidery. The front displays the iconic Yankees logo and the side flies the New Era flag. Yankees fans: Kick off the MLB season in this creative and colorful cap. If you've got a sweet tooth for fresh snapbacks, pick this one up today at Planet Sports. Stay #CommittedToTheCandy and cheer on the Yankees proud!


text:
3rd Line Support
Perm - Full time
Salary: £35-40KPA + Benefits
Location: Portsmouth
You must be eligible and willing to go ahead with a DV Clearance
Role overview
This is a fantastic opportunity for an experienced Systems Integration Engineer to cover both hardware and software support on a large and challenging secure MOD site. You will be providing third-line support to site teams and projects on this established and large scale account, one of their most prestigious Defence customers.
It is essential that the successful candidate is willing to undergo a DV Level Security Clearance process for this role, and is eligible to obtain this level of clearance prior to working on this secure Defence site.
Key responsibilities
* Provide integration reports on new software and hardware entering the estate
* Package and distribute software components to the Enterprise using Microsoft SCCM
* Assist and support of the corporate environment whilst maintaining it's integrity
* Administration of support queues - Incident and workload management
* Progress incidents and problems to their conclusion
* Report anomalies and escalate issues to Team Leader
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Essential skills
* Security cleared or eligible, prepared to go to Advanced Clearance
* SCCM Administration - Software distribution, OS deployment and monthly Patches
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Desirable skills
* Application sequencing
* Citrix


text:
Originally made as an experimental batch, Bad Guy is a wheated four-grain bourbon. It is 291's most award winning bourbon whiskey. It is 291's most bold, rich, and complex whiskey, heavier on the sweet side, this bourbon is incredible, given its high proof.
Made from corn, malted wheat, malted rye and beech smoked barley mash. Approximately 120 PROOF


text:
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Xin Zhao,
Xianling Jiang and
Zhaoyang Li
International Review of Economics & Finance, 2015, vol. 37, issue C, 55-68
We investigate the impact of the recent economic crisis on the financial performance of multinational corporations. The results show that multinational corporations in our study sample have increased more than 1.9 times (from $529.63million to $1544.82million) in their sales in Asia, and have increased 13.7 times (from $16.88million to $247.74million) in their sales in China from 1999 to 2012. Moreover, we find that the increase in Asian/Chinese percentage sales results in higher accounting performance after the crisis, in contrast to domestic firms. This result is robust and controls for firm and industry characteristics, and possible endogeneity issues. Finally, new entrant firms to Asia and China experienced an increase in ROA, while their matched firms and domestic firms did not. All these results indicate that firms which have taken aggressive actions (e.g., by strategically relocating their sales to other parts of the world such as Asia/China) experienced less adverse effects from the crisis compared with their domestic counterparts.
Keywords: Economic crisis; Percentage sale; Multinational corporations (search for similar items in EconPapers)
JEL-codes: G14 (search for similar items in EconPapers)
Date: 2015
References: View references in EconPapers View complete reference list from CitEc Citations: View citations in EconPapers (3) Track citations by RSS feed
Downloads: (external link)http://www.sciencedirect.com/science/article/pii/S1059056014001877
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DOI: 10.1016/j.iref.2014.11.013
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Thunder Mountain Rockfest 2010
Posted by: Thunder Mountain Rockfest |
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Don't miss your LAST CHANCE to submit to Thunder Mountain Rockfest, which will take place over 3 days on July 8-10, 2010 near Minot, ND. Over 30 of the best bands from the 70s, 80s, 90s, and today will be performing, including Night Ranger, Foghat, and Chuck Negron of Three Dog Night, The Guess Who, and Blood Sweat & Tears. As many as 5,000 people are expected per day. Bands are encouraged to sell merchandise and will keep 100% of the proceeds./n/nSummer thunderstorms are not unusual events in northwestern North Dakota. But come July 2010, the thunder you hear from southeast of Minot will be from an event that is anything but usual. "The Thunder is coming!" is the official slogan of Thunder Mountain Rockfest, a three-day outdoor rock festival coming to Sawyer from July 8-10. As many as 5,000 people are expected per day. Bands are encouraged to sell merchandise and will keep 100% of the proceeds.
Thunder Mountain Rockfest, located on the 80-acre Rock Dakota ranch 14 miles Southeast of Minot, will feature over 30 acts on multiple stages. Thursday will kick off as a '70s day, Friday is designed for groups from the '80s and Saturday's final day will include major acts from the '80s, '90s and today. Bands already confirmed for the festival include platinum artists such as Night Ranger, Foghat, and Kix, as well as Chuck Negron of Three Dog Night, The Guess Who, and Blood, Sweat and Tears.


text:
There's a mighty roar of oceans.
Oceans that want to reach out and pour.
A mighty roar of oceans.
That want to breathe life once more.
There's a new beginning.
Stripped bare from what was before.
As I shed my hair.
In to the wind.
Leave the one behind.
Who once was.
She doesn't fit in.
No in the concept of herself.
No more.
A need to move forward.
Or upward.
The old had no more room to grow.
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The silence too still.
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A touch to talk.
One word may breathe, breath, walk.
First I need to break.
To feel the wind within.
The willows bloom breath.
The heart breathes gold dust.
To dance as the field.
Without a care for more.
Poem – Helen Rebecca Hart.


text:
As Kanye fans sit anxiously waiting for "808's & Heartbreak" to release, Mr. West releases little snippets of the album to give us a small taste of what this new album is going to be like. Kanye just released the music video for his new single "Love Lockdown" which proves to be a very interesting video. Check out here at Sweet Kicks.
Sweet Kicks – Kanye West's Love Lockdown (Music Video)
Filed under Kanye West, Music


text:
MOUNT CLEMENS, Mich. – A man who pleaded guilty, but mentally ill, to killing his wife and two young children in their Eastpointe home has been sentenced to life in prison without parole.
Timothy Fradeneck used a USB cable to strangle his wife, Christie, 37, daughter, Celeste, 2, and son Timothy, 8, on April 13, 2015, in their home on Cushing Street. Their bodies were found by police who went to the home to check on the family after Christie's sister reported not being able to get in touch with her.
"You're right that you failed as a human being in an utterly, most awful way possible," said Judge Diane Druzinski.
Police said Timothy Fradeneck admitted to killing his family while they slept -- and had planned on killing himself but didn't follow through with it. Family members and Fradeneck's attorney said he is bi-polar.
Timothy Fradeneck pleaded guilty to first-degree and child abuse charges. He is expected to be sentenced to life in prison without parole.


text:
How viable is this currently? Any news? Would LOVE to see an Opel Manta 400! Real shame that SMS didn't include it in the Group B class.
Youtube/AMS2 - TekNeil Sim Racing [TSR]
My Mixer channel - Mixer.com/TekNeil
92 Vw Corrado G60 - CorradoG60.co.uk
I7-6700K @ 4.4Ghz / MSI GTX 1080 @2025 Core, +600 Mem / 16GB Ram @ 2800MHz / HTC Vive
The following 9 users likes this Post: Aile_Bleue, DAS.Zentrum, E_Luckow, hotak, massimiliano66, morpwr, Reiche, roddypoddy, Tank621
So when do we get to take it for a spin?
MOBO: asus rog maximus x hero / CPU: intel i7 8700k 5.1ghz / RAM:corsair platinum 32GB DDR4 3866-ocd4000 / COOLING: thermaltake floe 360 / GPU: asus GeForce RTX2080ti oc / PSU: evga super nova 850g2 / STORAGE: Samsung evo 500gb- Samsung evo 1tb / CASE: thermaltake core x71 / RIG:Gt omega /SimRacing Bay 30nm OSW / Heusinkveld pro pedals / Fanatec shifter /VR:rift / BACKUP: ps4 http://pcars.oscarolim.pt/
Is anyone working on other aspects of modding the game outside of adding cars? Adding a BoP option for classes, for instance?
I'd love to have a driver name editor for offline racing, per car livery, in each class, so the Crew Chief app can tell me: "The driver behind is Brundle" or "McNish" for example, if racing Group C or GT1.
i7-8700K | 1080 Ti | Oculus Rift S
YouTube: << GregzVR: VR Gameplay.


text:
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Storage Guardian Fast Failover
Fast Failover from Toronto-based Storage Guardian allows businesses to fail over their entire network to a secure data center in the event of a disaster. Once this service is set up, applications and data can be backed up using customers' existing data protection platform such as Veeam or Asigra. In a disaster, the failover is initiated by dialing into a 24x7 hotline and entering a secret PIN. Fast Failover can perform the entire workflow to spin up all apps and data to standby machines in a secure data center. The service then sends VPN links to staff to help them connect to the new hardware. Storage Guardian works with MSPs to resell this service.


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Buying 2nd floor flat having unauthorized 5th floor
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- Why will you pay for unauthorized construction on 5th floor, when your flat is on 2nd floor? The 5th floor owner will pay the penalty - he is the one outside the law - not you. If tomorrow you do some unauthorized construction in your flat, will the rest pay for it?CommentQuote0Flag


text: AIDS. 26(10):1261–1268, JUNE 19TH, 2012 DOI: 10.1097/QAD.0b013e328353f3f1 , PMID: 22472858 Issn Print: 0269-9370 Publication Date: June 19th, 2012 Print HIV reservoirs: pathogenesis and obstacles to viral eradication and cure Tae-Wook Chun;Anthony Fauci; + Author Information Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Checking for direct PDF access through Ovid Abstract Plasma HIV viremia can be suppressed and maintained below the limits of detection for prolonged periods of time in the vast majority of HIV-infected individuals who receive antiretroviral therapy (ART). Thus, the clinical outcome for HIV-infected individuals who have access to these drugs is dramatically improved. However, ART alone cannot eradicate HIV in infected individuals and this impediment is likely in part due to the persistence of viral reservoirs in the peripheral blood and lymphoid tissues of infected individuals despite the suppression of plasma viremia. In recent years, major research efforts have been dedicated to a better understanding of the pathogenesis of persistent HIV infection and to the development of therapeutic strategies aimed at eradicating virus in infected individuals receiving ART. In this review, we discuss the pathophysiology of CD4+ T-cell HIV reservoirs, including recent advances in our understanding of the mechanisms of persistent viral infection and perspectives for eradication of HIV in infected individuals.


text: Meet the ERNESTINE, the ultimate mid-calf boots of the season. These walkable booties are crafted from a variety of chic materials and finished with a coordinating stretch-infused shaft for a perfect fit. Set on a 45-mm block heel, the easy-to-wear style is an effortlessly chic addition to any look. We recommend styling them with a relaxed satin pantsuit or a sleek tailored dress worn over a turtleneck sweater.


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A Sacred Online Event SPEND VALENTINE'S DAY WITH ME!!! Are you ready to LOVE and BE LOVED in greater ways? In this sacred attunement, we'll move beyond the patterned programming of Love (which includes attachment and expectation), so that we may powerfully step into an all-encompassing DIVINE LOVE—one that helps us to feel safe, supported, appreciated, cherished,… Continue reading Attunement to Divine Love
Tag: meditation
The Truth of God
Prepare yourselves!! For the truth is something that might never be understood, but is already known. Forget everything that you think you know. This tale of all-encompassing Beingness is one that must be told. In truth, for a long moment, I had stopped using the word God in my vocabulary. I had felt abandoned and… Continue reading The Truth of God
"Who Am I??"
The questioning begins - more deeply than I have ever known. Perceptions of "Me" flitting through my mind-space, enticing me to be at peace with only one beautiful aspect of mySelf or another. It does not seem to be enough. In this sacred moment of supernal Being, it does not seem to be enough. My heart reaches further and further, to… Continue reading "Who Am I??"
To Breathe from Source
There's a point in all universal Beingness, that I envision as the SOURCE of all life-force. In this sacred point of divine presence, all reSource can be found. This perfect point of Light births all and heals all. When it's important for me to remember who I am, or to see clearly in a moment… Continue reading To Breathe from Source


text: HomePricesExchange news & prices ALUMINA SNAPSHOT: Fob Australia prices dip to $275/t after Chinese demand lull Key information from the pricing session for Fastmarkets' alumina index, fob Australia on Wednesday July 29. Key drivers: Deals concluded on Wednesday at $275 per tonne fob Western Australia for 30,000 tonnes with mid-August loading. Prior to this, the deal market had been quiet with no spot business since one deal at $280.50 per tonne fob Australia on July 22. Chinese market participants have stepped away from the market and were not looking for material as much as in previous months... Email this article Your details Your recipients's details You can enter a maximum of 5 recipients. Use ; to separate email addresses. Email yourself a copy? Enter the code: Cancel Ok To view this content, please take a free trial or subscribe to our service. Already registered? Log in Subscribe to the latest news: Personalized live and breaking news alerts Access live news and market information Access our market news archive back to 1997 Buy now Take a FREE 7 day trial: Access the past month's market insights Coverage from our experts embedded in the markets Try our global metal company database Take a trial Contact Us +44 (0) 20 7779 8260 firstname.lastname@example.com Published Alice Mason July 29, 2020 16:24 GMT London Keywords alumina alumina index alumina fob Australia China alumina China aluminium demand Related news {{article|snippet:'title'|removeHtmlTags}} {{article|fields:'dates'|date:dateArticleFormat}}


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Like it or not, it's looking quite likely that we'll see Hillary Clinton and Donald Trump as the presidential nominees this summer. Much will be decided via the widely viewed debates that are aired on national television. In an ideal society, the candidates would calmly discuss their positions on important issues and give the voting…
Category: Uncategorized
Flaneur or Dandy
Welcome to the site.


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We would like to thank our sponsor Julia Köhl Allianz Pferde OP- Versicherung!
Julia Köhl Allianz Pferde OP-Versicherung is the best partner for your equine friend; and she sponsors some amazing prizes too! During the 2019 ECQH, she will kindly offer a BIG D Halter set for the Level 1 Youth All Around Champion!
But this is not all; Julia Köhl Allianz Pferde OP-Versicherung will donate also two grooming totes for the Novice Youth Western Pleasure Champion and for the Western Pleasure Youth Champion. This is fantastic!
If you would like to know more about Julia Köhl Allianz Pferde OP-Versicherung, you can have a look at her Facebook page at the following link: https://www.facebook.com/Julia-Köhl-Allianz-Pferde-OP-Versicherung-1146564352136470/
The ECQH Team would like to thank again Julia for her sponsorship.
Welcome to the show!


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The SmarK Q'n'D Rant for WWE Hell In A Cell 2009
Glad I took the chance on this one and caught it at the theater tonight, because outside of some low points this was one of the better WWE PPVs in years.
– Undertaker d. CM Punk with the tombstone in a surprise opener. I guess they were wanting to space out the HIAC matches to prevent burnout, but it made for kind of a weird crowd dynamic here. Match itself was nothing special, basically a total squash by Undertaker with almost no chance being given for Punk to even get a near-fall, outside of a chairshot. Taker chokeslammed him, tombstoned him, and that was that. Fine for what it was, but what the hell was the point of this feud? Who does Undertaker even have for opponents now? ***
– Jim Morrison d. Dolph Ziggler with the Starship Pain after a couple of tries at it. Good and long match that looked it was building to a draw, but of course there are no time limits in the new WWE Universe, so instead Morrison fought off a bunch of near-falls and came back to win clean. I haven't seen enough of Ziggler to care about him doing the job here, but Morrison is the guy I like for the future, so good choice here. ***1/2
– Mickie James d. Alicia Fox with a tornado DDT that was botched about as badly as everything else here, to retain the Tramp Stamp title. Too long, and Fox did nothing for me. 1/2*
– Jericho/Show d. Rey/Batista to retain the Unfied tag titles in the match of the night, as Jerishow are really clicking as champions now with the awesome dynamic of Jericho being the little guy hiding behind the big guy. Plus Batista/Rey have the dynamic of the little guy who REFUSES to hide behind the big guy and gets his ass kicked as a result, giving us a crazy heated crowd who was into everything and an unbelievable heat segment and finishing sequence. And once again Show punches out the little guy for the pin, as that's apparently the champions' finish. Are they building up to DX being the ones to finally beat them? ****
– Randy Orton d. John Cena clean with the PUNT OF DOOM (which obviously missed by a good six inches, thanks to the wonder of HD) in the second Cell match of the night, to regain the title. This was really the same match we've seen a million times from these guys, as they have good chemistry together but didn't do anything to differentiate the Cell match from any of their other million matches. I liked it and Cena always delivers on PPV, but for the love of god find some new people to elevate so we don't have to rotate back to HHH-Orton yet again. ***1/4
– Drew McIntyre d. R-Truth with some sort of double-arm DDT thing. Fans turned on this instantly and gave it no chance to succeed, and Drew did nothing to distinguish himself. But then it took MVP a while to get going after a similar introduction, and look where he is now! A midcard babyface on RAW! Um, bad example, I guess. 1/2*
– Kofi Kingston (who is now from Ghana, as per real life, instead of Jamaica) d. Miz & Swagger to retain the US title in a match that was put out there to die and mostly did just that. Some wacky three-way spots at the end, but the crowd was in no mood and it died quickly. **
– D-X d. Legacy in the final Cell match of the night, and this was a hell of a deal that JUST missed classic status because Legacy doesn't quite have the star power to pull off what they were going for. Basically Legacy has no chance, so they attack D-X during their wacky entrance and lock HHH out of the Cell after mugging him on the ramp. Then Shawn gets the everloving shit beat out of him for about 15 minutes, drawing some CRAZY old-school sympathy heat and just selling it like nuts. Finally HHH retrieves bolt cutters and roars back as D-X destroys them and gets their revenge. Awesome stuff, as D-X finally starts playing the part of the old war-horses instead of the super-cool upstarts they still think of themselves as. As a match there's been better, but finally someone takes advantage of the Cell tonight and gives us a DIFFERENT dynamic, and I enjoyed the hell out of this, even if you could see the storyline coming down main street. **** This needed Shawn bleeding like a exploded tomato in the worst way, though.
Overall, strong thumbs up. Get the replay if you missed it tonight.
Tags: cm punk, Hell in a Cell, HHH, john cena, Legacy, randy orton, shawn michaels, SmarK Rant, undertaker, WWE


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Scientific Mes Technik Private Limited
Pologround, Indore, Madhya Pradesh
GST No.
View Mobile No.
Our Products
Digital Oscilloscope
Function Generators
Arbitrary Function Generators
Pulse Generators
Spectrum Analyzers
Digital Multimeter
LCR Meters
Benchtop DC Power Supplies
Programmable DC Power Supplies
Bi Directional Power Supplies
DC Electronic Loads
Solar Array Simulator
ESD Generator
Pre Compliance EMI and EMC Test Solution
Conducted RF Immunity Test Equpiments
Harmonics & Flicker Analysis
Burst Generator
Surge Generator
Voltage Interruption Simulator
EMI Recevier
Near Field Probe
Radiated RF Immunity Test Equipment
Line Impedance Stabilization Networks
HIPOT High Voltage Testers
Insulation Resistance Meters
Impulse Winding Testers
DC Resistance Meters
Battery Tester
Automatic Transformer Tester
Winding Component EST Tester
Power Meters
Power Analyzers
Frequency Response Analyzers
Selective Level Meter
IEC Impulse Testers
Ground Bond Tester
Signal Generator
Soldering and De-Soldering Station
Industrial Accessories
About Us
Registration & Directors Information
Corporate Video
Download Brochure
Pay with IndiaMART
Contact Us
About Us
Scientific Mes-Technik Private Limited
, established in
Test & Measuring instruments. The products offered include Oscilloscopes, Spectrum Analyzers, Function Generators, Frequency Counters, Digital Multimeters, LCR Meters, Lab Stations, Lab tools & Accessories and many more. Scientific also distributes a complimentary range of instruments manufactured by renowned companies from Germany, Korea etc.
Scientific, successfully and promptly, meets the challenges of changing technology. Our talented and experienced team provides instruments crafted with an eye for perfection. A vertical integration enhances the support offered to its customers' varied applications.
Our customers vouch for the rugged engineering of Scientific products. Products have been successfully tested to stringent Defence Standards JS 55555. Scientific products are known for their best 'Price-Performance ratio'.
The R&D Lab of Scientific is recognized by DSIR (Dept. of Scientific and Industrial Research), Govt. of India. The calibration Lab of Scientific is accredited with NABL in accordance with IEC-ISO 17025:2005.
Scientific has many feathers in its cap.
Our oscilloscopes won 'Best Product Design' award in 1984
First to manufacture Modular Test & Measuring instruments in India
First to manufacture DSO in the Indian market
First Indian manufacturer of T&M instruments to obtain NABL accreditation of its calibration Lab
Company Factsheet
Basic Information
Nature of Business
Company CEO
Mr. Anirudha Kela
Registered Address
B-14, Industrial Estate, Near SBI Bank, Pologround, Indore- 452015, Madhya Pradesh, India
Total Number of Employees
51 to 100 People
Year of Establishment
Legal Status of Firm
Limited Company (Ltd./Pvt.Ltd.)
Annual Turnover
Rs. 10 - 25 Crore
Statutory Profile
Tan No.
GST No.
CIN No.
Packaging/Payment and Shipment Details
Payment Mode
Bank Transfer
Shipment Mode
By Road
Why Us?
We ensure to timely deliver these quality Dc power supply and electronic loads to our clients, through this, we have gained a huge clients base in the market.
The key factors for which we have received appreciation from our clients include:
Highly experienced professionals
Wide product range
Positive records
Competitive prices
Prompt delivery
Well-equipped warehouse
Ethical business policies
Our Infrastructure
From the establishment, we have a well-equipped and state-of-the-art infrastructure. Also, we are divided into designing, manufacturing, quality testing, packaging, and many more departments. This also facilitates quality testing units of the manufactured Dc power supply and electronic loads, to make sure that these meet the industry quality standards.
ISO Certification
Issue Date: 19-12-2012
Expiry Date: 18-12-2021
Our Infrastructure
From the establishment, we have a well-equipped and state-of-the-art infrastructure. Also, we are divided into designing, manufacturing, quality testing, packaging, and many more departments. This also facilitates quality testing units of the manufactured Dc power supply and electronic loads, to make sure that these meet the industry quality standards.
Our Vision
"To deliver precise measurement solutions at competitive costs, to provide world class calibration services using quality resources, and to achieve complete customer satisfaction through management excellence".
Reach Us
Mr.Anirudha Kela (Managing Director)
Scientific Mes Technik Private Limited
B-14, Industrial Estate, Pologround
Indore - 452015, Madhya Pradesh, India
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error with efibootmgr
Hello, I need help dual booting linux mint 17 xfce on mid 2010 macbook pro.
I followed the tutorial http://community.linuxmint.com /tutorial
/view/1643, but used dvd for mint install, xfce in stead of cinnimum, and I
didn't make a home partition (just linux mint and swap in osx disk
utilitys). For the install I clicked "something else" and changed the 2
partitions only. When I clicked install I got a warning that I should have
at least a 1mb partition for something or mint may fail at a later time. I
didn't know what to do and clicked ignore to install. After mint installed
I installed efibootmgr in command prompt and when I ran it, I got an error
"fatal: could't open sysfs or procfs directories for accessing EFI
variables. Try 'modprobe efivars' as root"
I don't understand the error. Any ideas how to get efibootmgr working?


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About Us
BESPOKE \bi-ˈspōk, bē-\ a : custom-made b : dealing in or producing custom-made articles
When the Bespoke line of wheels was established designers, one of the easiest aspects for us to decide upon was our name. Our goal was to have a simple effective name that would communicate the essence of this new series of wheels.
Our goal was to offer a simple and elegant line of wheels that would cater to a wide audience in both designs, vehicle applications, and construction. The one aspect that would not be compromised was our philosophy. This simply states is the fact that premium wheels, just like premium clothing must be made to order, and not simply be stocked along in bulk in some warehouse of wheels.
We are very proud to offer this elegant collection of varying designs and applications to the automotive market, and hope that you will join the growing number of automotive enthusiasts that can appreciate a proper custom made product.


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+1 781.825.1279
Michael Lee
Senior Director of Finance
Michael has been a consultant to early stage companies, assisting with financial management and venture fund raising. He has a passion for introducing new technology and streamlined processes that enable an organization's infrastructure to support high growth.
As a consultant for Harvard University he designed and implemented a comprehensive metrics reporting system to assess the effectiveness of 14 separate development teams raising over $500,000,000 annually. In 1998, Mr. Lee co-founded and was CFO for ConsumerREVIEW.com, an early Internet innovator in the online community field. As a consultant with Symmetrix and Bronner Slosberg Humphrey (now Digitas), he led a range of analytical and operations projects for firms in the financial services, insurance, and publishing industries. Earlier in his career he was in finance and systems development at Oracle Corporation.
Mr. Lee earned a Masters in Business Administration from the Harvard Business School in 1992. He also received a B.S. in Operations Research from the University of California, Berkeley (College of Engineering). Michael, with his wife Betsy, live in Sherborn and have one daughter who is in her junior year at the University of Richmond. Michael served two terms on School Committee for the Dover-Sherborn Regional District and is an active member of Wellesley "Village" Congregational Church where he serves on the Stewardship Committee. He also supports the non-profit sector in Boston by participating in pro bono consulting projects with fellow HBS alumni. What energy he has left is spent trying to exercise his dog Brady sufficiently that he can be calm at night. While Brady has the good looks and ego of TB12, his personality is closer to Gronk.


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We offer Methodist Speed Dating as well as the option to take your time and set your Contact Restrictions to only hear from those who meet YOUR criteria.
Check back often for updated tips and insights to help make your relationship a success.
Methodist Camp is full of single men and women like you looking for dates, lovers, friendship, and fun.
Finding them is easy with our totally FREE Methodist Camp dating service.
Register now to begin your eharmony experience and complete your Relationship Questionnaire.
If you would like to date Christian women or Christian men specifically, make sure to adjust your criteria to reflect this preference.Out of all the singles you may meet online, very few are actually compatible with you, and it can be difficult to determine the level of compatibility of a potential partner through traditional online dating methods.


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Famous TV and Movie Cars and Motorbikes
Posted on 20th July 2020
James Bond had access to all manner of vehicles – ones that flew, went underwater (like the Lotus Espirit) or whatever the chase required. Aston Martins were Bond's signature car and feature in many Bond movies.
Read more
The Best Mobile Apps for Motorists
Posted on November 15, 2018
Smart mobile phones and tablets haven't been around for very long but it's difficult to remember what life was like before them and bewildering to think that we managed to survive without them! Would you believe that there are more mobile phones in New Zealand than people? – although sheep still come at the very top at the pyramid! We might sometimes regret that time when it was fine to not be connected, sometimes at least, but it must be said that Apps have revolutionised our lives and made it so much easier to manage the day-to-day. Never is it truer than when we are on the road and we need access on the go to check directions, opening times, pay some bills, etc…
Some of the big players like Apple and Google have even very cleverly developed proprietary systems so that mobile Apps can make the transition into the motoring world, with vehicle integration, through clever infotainment connectivity like Apple CarPlay™ and Android Auto™, the technology allowing some Apps to be displayed and used via the media controls.
Manufacturer-specific Apps
Some car manufacturers have developed useful Apps to manage your vehicle which can transmit data through a USB cable or wirelessly via Bluetooth or the mobile network. They usually are driving statistics, location tracking or controlling cabin temperatures.
- Tesla
With Tesla's App for example, owners can communicate directly with the Powerwalls anytime and lock/unlock their vehicle without a key. They can check their driving range and their charge status and, even more interesting, they can receive a notification when their car is fully charged so that they don't have to come back and check periodically on its progress.
If you have ever been parboiled when coming back to your car after it has been cooking slowly under the summer sun, you will feel envious that Tesla owners can vent their vehicle and turn on the climate control system remotely to come back to a cool cabin.
GPS locating, while seemingly a basic feature, will be greatly appreciated for those of us who regularly realise after going shopping that they actually have no idea where they left their car.
The Valet mode allows owners to restrict access to their data when they hand over their car for servicing for example.
- Hyundai
Hyundai's Auto Link also provides owners useful information about their car such as signs of faults or vehicle location. It also keeps tracks of fuel efficiency statistics.
Although EVRoam isn't an App as such but a database, we wanted to mention it as it will feed dozens of Apps in NZ and could be a game changer as far as the adoption of electric vehicles in the country is concerned. People tempted to buy an all-electric car are often held back by the fear of not being able to find a charging station when they need it and find themselves stranded.
Created by New Zealand Transport Agency in collaboration with partners such as vehicle charging infrastructure providers ChargeNet and Vector, and the NZ Automobile Association, it will give EV owners up-to-date information about charging stations and enable them to plot their route accordingly.
Gaspy is a really useful free App that records fuel prices nationwide so that you can easily compare offers in your vicinity and get the best prices wherever you are. It is a 'community' App which relies on feedback from New Zealand motorists. It was developed by IT software development company Hwen based in Tauranga and is available for iPhone and Android OS.
AT Park
Cars are great. Until you need to find a parking spot for them and then you feel like a prisoner going round and round through city centres with your eyes peeled for one of those elusive creatures. That's when you realise you haven't got any cash to pay for the meter...
Thanks to Auckland Transport's AT Park you can now pay directly from your phone, without having to wrestle with a parking machine or having to display a ticket.
Waze is a location App for Smartphones and tablets with GPS support. It can be used as a SatNav but also gives you information about traffic, roadworks and crashes in real time so that you can avoid getting stuck in a soul-destroying traffic jam.
Car sharing Apps
Car sharing Apps have mushroomed over the last few years, and you can understand why as it really is a win-win on all fronts.
Sharing cars reduces the number of vehicles on the road, and therefore congestion and pollution; it helps people without a car travel to destinations that would otherwise perhaps be unreachable, or they make their daily commute easier and cheaper. Car owners receive a contribution from travellers, which compensate them for added wear and tear, car maintenance and fuel costs – but the principle is that they shouldn't make a profit. Car pooling is therefore a way to make keeping a car more affordable.
There is a range of such Apps including Cityhop in Wellington and Auckland, Mevo Car Share in Wellington or Chariot Ridesharing. The App also offers the advantage of cashless payments, like Uber, pre-agreed ride fares and ride reviews. An important aspect of carpooling is ensuring the safety of everybody involved given that you are, basically, getting into a car with complete strangers. Chariot Ridesharing has the advantage of displaying background checks on the website which certainly make people feel safer.
Car Mate NZ
This App offers a platform to buy and sell second-hand cars as well as offering discounts on car servicing and maintenance. It is particularly appreciated by people wanting to sale their car as doing so is commission free.
If you are looking for an experienced shipping company to import or export you car, contact McCullough on +64 9 309 1163 or email us to discuss your needs and find out how we can help you.
Famous TV and Movie Cars and Motorbikes
Good Passenger/Bad Passenger – which are you?
Posted on 17th June 2020
Some people are hard work as a car passenger. Yep, you know who we're talking about and they literally 'drive you to distraction'. Who's knows, you might even be one yourself! Bad passengers can make drivers stressed and distracted, and if they're distracted then it's dangerous for everyone. Remember these tips next time you are the passenger.
Read more
Cool Campsites in the UK
Posted on 22nd May 2020
If you reside in the UK and looking forward to a summer holiday (especially after a very out-of-the-ordinary year so far), we've got a great range of campsites to park up the campervan and become one with nature. As expected, international travel is minimal (if at all) around the world, so local tourism businesses will happily welcome your holiday spending.
Read more
Changes to Motorhome Depreciation Rate
Posted on 17th March 2020
There has been a big change to the depreciation rate on motor vehicles and motorhomes. New Zealand Customs recently announced there is a change in the depreciation rates applied to motor vehicles and motorhomes from 1st of March 2020.
Read more
Our easy - 3 step shipping process×
Tell us the pick up location and we'll arrange a date & time
We handle all customs & shipping including insurance
Enjoy your toy, after it's delivered to your door anywhere in NZ.


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Abstract and Keywords
This chapter analyzes the development of Swedish economic policy from the early 1920s to the present. The chapter has three objectives: to describe how Swedish economic policy-making has evolved over time, concentrating on a few especially important periods: the adoption of expansionary fiscal policies in the 1930s, the development of Sweden's postwar economic model in the 1950s, the struggle to maintain full employment in the 1970s and 1980s, the financial crisis of the early 1990s, and Sweden's response to worldwide recession in the 2000s. The second objective is to show if and when Swedish governments have pursued economic policies that set Sweden apart from other rich democracies; and the third is to examine a number of scholarly debates concerning how to explain some of the economic policy shifts that have occurred in Sweden since its transition to democracy in the 1910s.
Keywords: economic policy, Great Depression, postwar boom, economic crises, unemployment
Access to the complete content on Oxford Handbooks Online requires a subscription or purchase. Public users are able to search the site and view the abstracts and keywords for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can''t find the answer there, please contact us.


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Moon Light
Moon Light
Take in the magical beauty of the moon every night with the Moon Lamp, made with an amazingly detailed 3-D lunar landscape that adds a unique and modern touch to your desk.
Mobile and Rechargeable: Bring this nightlight with you into a world of mystery and romance
Ideal Nightlight: A hidden touch button can change the light from white to a comforting yellow
Perfect Gift: A perfect gift to anyone you care about
• Mobile and rechargeable
• Made with a plastic body and wooden holder
• Available in sizes from 15cm to 20cm in diameter
Bring the magic of the moon to your room!
Create a sense of wonder on your table with the amazingly detailed moon light.
- Reviews
- Questions
- gift
- lamp
- colors
- charge
- quality
- purchase
- moon light
- size
- moon
- remote
Nice, I wish it would stay light longer after the charge. Trying to tell if that what lights up is exactly the moon surface. I am giving the other one as a Christmas gift.
I love this lamp. It is very authentic replication of the moon.
I was so happy I finally have it I love the texture, the quality also good. Thank you
Hubby loves it for his office. Great birthday present, especially for a person who loves astronomy, NASA, solar eclipses
A really lovely gift.


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Marriott Bonvoy Home
Find & Reserve
1 Room: 1 Adult, /Room 0 Children/Room
(Age-based rates may be available)
Enter Code
Deals & Packages
Meetings & Events
Innovative spaces. Inspired experiences. Personalized services.
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About Marriott Bonvoy
Sheraton Pilar Hotel & Convention Center
Panamericana KM 49.5
Pilar, 1629 Argentina
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Hotel direction: 37.3 miles SE
On-site parking, fee: 3 USD hourly, 7 USD daily, 7 USD per stay


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Novel Coronavirus (COVID-19) update: due to many cancellations, it's important to check with event organisers if events currently in the calendar are taking place. If attending public events, please follow advice regarding washing your hands and wearing a mask, and exercise social distancing as advised by health authorities.
TSO: Letonja & Skride
- Date: Friday, 16 August 2013, 7.30 pm
- Venue: Federation Concert Hall, Hobart — 1 Davey St, Hobart, TAS
- Tickets: $113 - $29 — Tickets can be purchased online or by phone on (03) 6232 4450
Event Details
Since winning the prestigious Queen Elisabeth Music Competition in 2001, violinist Baiba Skride has performed with the world's leading orchestras including the Berlin Philharmonic and London's Philharmonia Orchestra. In this, her second appearance with the Tasmanian Symphony Orchestra, she performs Benjamin Britten's Violin Concerto, a powerful and emotional work from the late 1930s written in response to a world on the brink of war. An important new commission by Andrew Schultz pays homage to Britten while works by Mozart – a favourite overture and a great symphony – bookend a concert of exceptional music and an exceptional artist.
Featured non-Australian music: Britten Mozart
Further information for this event is available online at the event's website or by phone on (03) 6232 4444 or by email to firstname.lastname@example.com
Featured artists
- New work by Andrew Schultz
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Private View 28th November
Exhibition Continues Until 4th December
Address The Factory, 21-31 Shacklewell Lane, London, E8 2DA
Socially, politically, and economically, we are living in trying times. These difficulties create division, and division breeds competition. We endeavour to support all art-world practitioners wherever possible, whether they reciprocate or otherwise, and to collaborate with what would (by some) be called our direct competitors. We believe that the art-world would be a much more open, supportive, and progressive place to work if we started working together, rather than pulling apart. For this reason, Delphian and Guts have decided to join forces.
Exhibiting Artists
Douglas Cantor, Florence Hutchings, Geoffrey Bohm, Igor Moritz, Jake Grewal, Lauren Roche, Morteza Khakshoor, Rachael McCully, Sebastian Eriksson, Sunyoung Hwang, Tania Alvarez, Valerie Savchits.
Generously supported by The Factory and Crate Brewery.
Delphian x Guts
Acrylic and oil on canvas
132.5cm X 152.5cm
Oil on canvas
120cm x 80 cm
Oil, oil stick, and charcoal on canvas
56 x 71cm
Oil on linen
60cm X 80cm
Multi-plate etching and aquatint on paper
38cm x 47cm
Acrylic on panel
41 x 51cm
Acrylic, oil pastel and markers on canvas board
25.5 x 30.5 cm
Rough celestite, acrylic, markers and clay
12 x 28 cm
Acrylic on linen
60 x 75cm
Acrylic on canvas
81 x 81cm
Oil and collage on linen
50 x 50cm
Oil on canvas
21 x 29.7cm
Oil, wax, and soft pastels on paper
50 x 70cm
Ink, acrylic pigment, acrylic varnish,
on cold press paper.
56 x 76 cm


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Charity Calendar Dad Bods and Rescue Dogs 2020 Is The Perfect Gift This Christmas
We are now in the second week of December and people are busy with their Christmas shopping searching for the perfect gift to give friends and family. Keeping that in mind, although we may look at Christmas as a holiday of gifting and receiving and even spending time with family but it also doesn't hurt to introduce a sense of charity and meaning into the celebration to bring out the true spirit of Christmas. One non-profit dog rescue organization by the name Lucky Bulldog Rescue brought out hilarious calendar for 2020 called Dad Bods and Rescue Dogs in an attempt to raise money for the organization and it has become an instant hit going viral.
This is an amazing idea because not only is it funny but it also is for a good cause where the proceeds of the calendar go towards the upkeep of the rescue dog centre. The calendar was photographed by one of the volunteers and board members, Lyndsey Wright.
Wright easily found the best volunteer models top make the calendar come to life. It was not a hard task to do so. She posted on her personal Facebook account and got an immediate response. The calendar was already about to be a success.
Wright said "I made a post on my personal Facebook page telling people what we were doing because I knew I had some friends who would be great for this project. One of the models is a photography client. I mentioned during their session if he'd be willing to model and we did it right then and thereafter their family photos!
When the photographs for the calendar were published, it was an instant hit and people immediately started sharing them which made the project viral. As you can see, there is a huge element of humor and rather than using models with six-pack abs, Wright has used regular men with dad bod to lend a more humane and realistic touch for the calendar.


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Blog and news
Apr 30, 2020
Covid19 Update: Dependable Supply When You Need It Most
As you will be aware, the transmission and impact of COVID-19 Coronavirus has been increasing in Europe and across the globe. We take our responsibilities and reputation seriously, and have been busy ensuring that we have robust supply lines, or alternative products available, wherever possible. We have been in regular contact with all suppliers within...Read More


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text: News Beach volleyball 06/08/2016 Gibb roles back the year as he and Patterson start with a win Rio de Janeiro, August 6, 2016 – USA's Jacob Gibb and Casey Patterson began their Rio de Janeiro 2016 Olympic Games campaign by beating Qatar's Jefferson Pereira and Cherif Younousse Hermannova 2-0 (21-16, 21-16) victory at the Copacabana Beach Arena on Saturday. Here's what they said after the match….Jacob Gibb, USA"It was fun. That is exactly what it was. Sometimes I think you forget that this game is fun and you're just grinding out there and you forget about it, but that was fun out there."It was interesting, I even had fun in my warm-up and I don't usually have fun in my warm-ups. When you're 40-years-old you start to enjoy things and I'm enjoying every moment with this kid. "It is pretty cool playing beach volleyball in Brazil, but just because we are having fun doesn't mean we aren't taking it seriously."Casey Patterson, USA"He provides a lot of stability for me and right before we went out he gave me a little pep talk and we both got a little emotional, but then we got it out of the way and that was all we needed. "For me a big part of my style is emotion, so coming from him as well is big. "There's been a lot of waiting around. I feel like we've been here a month already. I'm a guy who likes to play and hurry and go and I've learned to pace myself and that is something he's taught me. I'm pleased it's my first Olympics and to be able to come out with a controlled, patient win, I'm learning and I love it."Cherif Younousse, Qatar "I am so proud for me and I am very happy to play the Olympics and be the youngest player in the men's (tournament). "It is so different, the court is so huge and we got lost at the beginning of the first sets as we were playing against two very experienced guys and now we know we are in the competition. "After we won the Continental Cup I just thought about it. I just need to use the experience and just enjoy it."Quick links - Beach volleyball:Rio 2016 Olympic Games - Beach volleyballRio 2016 Olympic Games - Beach volleyball scheduleRio 2016 Olympic Games - Beach volleyball - Teams - MenRio 2016 Olympic Games - Beach volleyball - Teams - WomenRio 2016 Olympic Games - Beach volleyball - Media GuideRio 2016 Olympic Games - Beach volleyball history Print this Page News {{item.LocalShortDate}} {{item.Title}} All the News


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