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January 22, 2018 / Astoria Neighborhood / Queens Community Issues / Queens Buzz NYC.
A week ago I headed over to the Redken Saloon Salon in Astoria for the 7th annual Save the Stache fundraiser. I had attended the event last year, watching quite a number of local celebrities for a day, shave their beards and mustaches in order to raise funds for QSAC which is the acronym for Quality Services for the Autism Community.
Quality Services for the Autism Community [aka QSAC] has programs designed to help families enable their children to do more for themselves as well as the community. QSAC offers emergency fund assistance for unexpected crises as well as reimbursement options for some of the things not covered by other government / private / social programs. The organization also provides respite services in the home as well as overnight stays away from home, to provide a bit of a break to the caregivers. And QSAC helps families find and coordinate services to help children with autism, as well as providing offsite "home environments that foster independence, community integration, individualization and productivity".
January 10, 2017 / Astoria Neighborhood / Queens Neighborhoods / Queens Buzz.
It was the first weekend night of the New Year, which after the relaxing holidays generally tends to be fairly low key. The streets were quiet on a clear, cold January evening as I made my way up 30th Avenue toward Steinway Street. I didn't really know what to expect at the Shave the Stache benefit at the Redken Saloon Salon, where the event has been hosted for the past five years.
Unlike the silent streets, the Redken Saloon Salon was bustling with life when I arrived. I was warmly greeted by members of the Quality Services for Autism Community [aka QSAC], as I made my way into the salon.
One of the first people I met was William Balash. He's a big man, who at the time, was sporting a hearty crop of whiskers, which he told me he'd been growing since October. He introduced me to Patricio Barrientos, External Affairs Coordinator of QSAC, who provided me with a bit of background information about the group, including that it was founded in 1978 by Queens parents of children with autism who were searching for more productive ways to raise autistic children, than were currently available at the time. Today QSAC serves 2,100 people with autism in NYC and on Long Island.
In the photo at right are the men who had their whiskers shaved, alongside those who shaved them. Back row from left to right are: Mike Christoforotos, Spiro Aganastopoulous, Janos Kanta, Nicholas Halvatzis, Jerry Crisafis, Joe Vaccaro, Sofia [hair stylist], Ken Marzocco, and Paul Halvatzis. The two men kneeling are Nicholas Zikos and Bill Balash, while the two men seated are Steve Sirgiovanni and Larry Litwack, with Redken Saloon Salon owner Frank Arcabascio standing between them. Last, but not least, is Jim Halvatzis standing far right.
William and Patricio introduced me to Katrizyna [aka Katrina] Kozena, of Art for Healing NYC. Katrina told me that the group was founded circa 2001 and gets artists to donate works which are auctioned off at fundraising benefits to help those in need. The proceeds from the auctioned art are shared by both non-profits and the artist receives free publicity. Art for Healing doesn't provide art therapy, which oftentimes includes interpretation of artworks after they've been completed; but rather Art 4 Healing uses art as a means of enabling people to emotionally connect with themselves in ways that may not be available in daily life.
Katrina showed me the work being auctioned off this evening, which was a wood painting by a Latin American artist. The artist's name is Angelo Romano who currently lives and works in NYC, but is a Spanish artist immigrant from Latin America. The work was a hand painted wooden totem pole – acrylic on wood. In the photo at right is Katrizyna Kozena of Art4Healing.org.
Click here a bit later today for the rest of the story including more photos and video about Shave the Stache benefit for QSAC in NYC.
October 30, 2016 / Astoria Neighborhood / Holidays in Astoria Queens / Queens Buzz.
It was ghoulish, it was hairy and in fact it was just plain, downright SCARY. There's just no other way to describe the Astoria Family Halloween Parade.
There were ghosts, goblins, witches, monsters and people back from the dead. They came by the hundreds and in all sizes. They were tall, small and everything in between. There were likely over one thousand people who came to participate in the tenth annual Astoria Family Halloween Parade.
Yet, even though I was surrounded by all of these frightening monsters, I felt a certain calm. Why? Why so calm amidst all of this horror?
Because there were possibly even more superheroes in the crowd. Wonder Woman, Superman, Batwoman, Batman and how about those Ninja Turtles?
The ghouls, goblins and their parents congregated at Ditmars & 31st Street beginning at 11.30 am filling all four corners and then some with plenty of people decked out in full Halloween garb. The weather was amply cooperative climbing well into the 70's and I heard some of the monsters complain that they were overheating … but not the devils … they seemed to feel right at home – if not a bit chilly.
The police cordoned off one lane of Ditmars between 31st Street and Astoria Park and at noon, the families packed up and marched down to Astoria Park along the East River. The families came streaming down the Great Lawn and started taking their places on the grass in front of the stage erected by the Central Astoria Local Development Corporation also known as CALDC.
CALDC had organized a Halloween event, which they called the First Annual Batty Over Halloween Celebration. The free event included face painting, balloon twisting, a children's Halloween sing along, cotton candy and munchkin pumpkins giveaway.
All in all it made for a fun outing for the kids and parents of the neighborhood who embraced both the parade and the Halloween after party. The parade was started around 2006 and continues to be organized by the Astoria Moms Meetup Group and Queens Mamas.
Click here to view the Astoria Family Halloween Parade 2016 slide show.
May 31, 2016 / Astoria Neighborhood / Ethnic Culture in Queens / Queens Buzz.
On Saturday May 21st from 1.30 until past 6 pm, there was a series of cultural performances held on the Great Lawn of Astoria Park. The event was hosted by the Central Astoria Local Development Coalition [CALDC] to showcase the multi-ethnicity of tne neighborhood.
Nearly a dozen local cultural groups performed, including Ballet Los Pampas representing Argentina, KUD Halaturko representing Bosnia, Croatian Franciscan Fathers Youth Club, Ayazamana Cultural Center representing Ecuador, Cretan Association representing Greece, NYC Bhangra representing India, McManus School of Irish Dance, The Braata Folk Singers representing the Caribbean / Jamaica, and the Korean Traditional Music and Dance Center.
There was a crowd that numbered in the hundreds over the course of the afternoon. Many brought lawn chairs and blankets to sit upon while they watched the show. The weather cooperated as the temperature was in the 60's and while at times cloudy, it was dry.
Several food vendors came out to augment the cultural celebration, now in its second year. As I came late in the afternoon, I had missed the prime time of that part of the event. In the photo at right you can see one of the performers walking up the Astoria Park Great Lawn after her performance.
Click here for a brief video of some of the 2016 International Culture Festival in Astoria Park.
November 23, 2015 / Astoria Neighborhood / Modern Dance in Queens / Queens Buzz.
I just returned from one of the most exciting dance performances I've seen in a long, long while. The dances were performed at the Frank Sinatra School of the Arts in Astoria on Saturday night. Unfortunately, DanceWorks performances may only be seen twice a year and the next one isn't until May 21st 2016 at this same location.
The show opened with a short introduction by DanceWorks Founder Lisa Mara, and DanceWorks New York City Director Jackie Arcy. Their introduction was followed by a dance video. And then the show began.
The show presented about two dozen original works and literally included a cast of about 140 dancers and choreographers. All of the dancers and choreographers had auditioned to participate in the show and then practiced and rehearsed for 16 straight weeks. The show lasted two hours, but the time flew by.
The photo above shows one of the dance performances at DanceWorks New York City at the Frank Sinatra School of the Arts.
Click here to read the rest of our report about the semi-annual performance entitled DanceWorks New York City NYC at the Frank Sinatra School of the Arts in Astoria.
January 19, 2015 / Dutch Kills LIC / Art Exhibits in Queens / Queens Buzz. It's not often one gets to see a bit of history in the making. But last Saturday evening I made my way to the QNS Collective in Astoria / LIC to see a bit of it.
The event was the opening reception of We Will Be Here, a photographic exhibit by Salvador Espinoza about the changes taking place in the Dutch Kills neighborhood of Long Island City. The exhibit included 13 framed photos hanging on the walls of the second floor of the QNS Collective, a modern new office space in Astoria / LIC. Another twelve will be rotated into the exhibit during the course of its showing which runs through February 6th.
The photos are a recent look at the changes taking place in the Dutch Kills neighborhood. The photos were shot in black and white over the past year, and provide a personal glimpse of the development of the Dutch Kills neighborhood by someone who grew up in it and has spent the better part of his life living there. The photo above shows Salvador standing in front of one of his photos where his brother held up a photo of a vista one would previously encounter while standing at the Queensboro Plaza subway station, which is now hidden behind a number of shiny new highrises.
Salvador told me that he moved out of the neighborhood for a few years [to Sunnyside] and he frequently returned to visit family and friends. He started noticing significant changes to the neighborhood occurring between each visit. He thought that someone should start recording the changes, because the neighborhood he grew up in, would soon vanish into the past. After giving the idea some thought, he concluded that perhaps he was the one to do it. So he reached out to the Queens Council on the Arts and they provided him with a small grant to pursue the project.
Many years ago Salvador had been an amateur photographer, and when he took up this project, he began anew. Over the course of the past year he started taking photos of the neighborhood including some of the everyday houses that likely will soon be demolished and replaced by apartment buildings, as the value of Dutch Kills real estate has skyrocketed in recent years.
Some of his photos include his neighborhood friends. I met Chris of EQ Lyrics, who is included in one of the photos of the exhibit. Chris had just completed a music video and tonight - as part of the exhibit opening - we were to witness the first public showing of Chris's music video. Salvador directed it and Chris plays the leading male role.
The lights dimmed, the crowd gathered around in a sort of amphitheater configuration, and the video began. The video is shot entirely in the LIC / Dutch Kills / Astoria neighborhood. The video is called A Beautiful Day which Chris told me was about, "getting drunk and banging chicks in the city" [a photo still from the video is to your right]. We've embedded the video at the end of this story.
Click here to read the rest of our story about the photo exhibit We Will Still Be Here, about the changing face of Dutch Kills real estate, at the QNS Collective through February 6.
October 19, 2014 / Astoria Neighborhood / Queens Culture / Queens Buzz. It's not often one stumbles upon a legend and then finds himself riddled in its mysteries. But so it was last Saturday evening, while biking through Astoria Park that I encountered an older gentleman who called to me asking for help. It was near dusk as the sun began setting behind the skyline and the shadows grew longer.
He was sitting on a park bench overlooking the Hell Gate Bridge and dressed in clothing of years gone by. He had not shaved in several days and his hair was a bit disheveled. I sized him up as I approached and determined that he was probably ok.
"Hi. What's up?" I asked.
"I need help." He replied. I looked at him inquisitively as he didn't appear to be in any immediate predicament, near as I could tell.
"What can I do for you?" I asked.
"I see by your bag that you work for a [web] magazine. Are you a reporter?" I nodded affirmatively. He pulled some photos from his coat and handed them to me.
I started thumbing through them, seeing what seemed to be photos of ghosts flying through the Astoria neighborhood. The photos weren't that clear and mostly in black and white. I didn't really know what to make of them.
The man looked at me intently, as if to measure my interest. "I'm trying to get back in." He said. I looked at him stupefied. "What?" He repeated, "I'm trying to get back in."
"I heard you the first time, but I don't understand what you mean." I replied.
He went onto explain. "The Hell Gate Bridge began construction over one hundred years ago. The construction went on between 1912 and 1918. I was one of the construction workers and every year right around Halloween we'd throw a party in this neighborhood, near a cemetery."
"Nobody believed it at the time, but there were rumors that the cemetery was haunted and that those who walked through it around Halloween time, risked losing their body to one of the ghostly spirits. It seemed like pure nonsense, even at the time, one hundred years ago, as new scientific breakthroughs were being made all the time. Trains, autos, light bulbs and bridges like Hell Gate were examples of the huge changes we were seeing. Nobody really believed it, and certainly not me … but I was wrong."
Click here to read the rest of the story about the Legend Of Hell Gate Horror.
The following is a list of the NYS Health Insurance Navigators as of November 12, 2013. You can also find these on the NYS Health Insurance website.
Click here to review a summary report outlining the many aspects of the Affordable Healthcare Act / Obamacare in Queens.
And click here for a list of NYS Health Insurance Exchange Navigators.
May 5, 2013 / Long Island City & Astoria / Biking Queens / Queens Buzz. This Sunday some 32,000 bicyclists rode through Astoria and LIC on their way to completing a 40 mile bike ride through all five boroughs of NYC. Photographer Abdel Berrera caught up with them at the Astoria Park rest station where many took a moment to catch their breath.
Many of the cyclists come from other countries and other states. The bikers see this as a nice way to see all of New York City, not just Manhattan.
There are two 5 Boro Bike Tour rest stops: the first in Astoria Park and the second at the Con Ed rest station along the East River. Many took some time out to make adjustments to their bikes, gear and selves; and consumed a bit of food before resuming the relaxing trip and heading on to Brooklyn and Staten Island.
Click here to read a brief report and to see a photo slide show of the 5 Boro Bike Ride in Queens shot by Astoria photographer Abdel Berraha.
March 19, 2013 / Astoria Neighborhood / Queens Schools / Queens Buzz. Editorial / Report. We attended a Community Board One Meeting Tuesday evening, following up on the concerns of Astoria parents, regarding the proposed changes to PS 122, which were recently announced by the Department of Education [DOE].
Having spent a week in pursuit of information from the DOE about the proposed changes – statements regarding the difficulty in obtaining information from them - rang true.
In the photo above, Anastasia Cunningham and her son talk about how the Dept of Ed hasn't put anything in writing, hasn't conducted any impact study, and she talked about how the changes could possibly destroy the learning environment that contributes to the success of PS 122 in Astoria.
Click here to read the rest of our Editorial / Report on the Community Board One Meeting regarding Department of Education proposed changes to PS 122 Astoria. Story & photos by Michael Wood.
March 17, 2013 / Astoria Neighborhood / Queens Schools / Queens Buzz. The Department of Education announced its intention to make sweeping changes to PS 122 on February 28, 2013 to the PTA of the school. We were told of the general gist of these changes by PS 122 PTA members and parents. We then followed up with the Department of Education, to be sure we understood the Department of Education's announcement correctly.
Before we discuss the general gist of the Department of Education plans for PS 122, it helps to have a bit of background to better understand what appears to be happening.
There are several important elements that seem to be at the core of the issue: 1) the Department of Education's plans to reconfigure one of the most successful public elementary / intermediate schools in Queens and the NYC school system, 2) the Department of Education's sudden interest in providing the school children of PS 122 grades K through 5 with the opportunity to continue matriculation within the same school [building] throughout all eight grades [6 – 8], and 3) Success Academy Charter Schools announcement that they plan to open a new charter school in Queens school district 30 in August of 2014.
Click here to read the beginning of our DRAFT report about the Department of Education Plans to reconfigure PS 122 in Astoria. Be advised that there is a Community Board One Meeting March 19, Tuesday evening beginning at 6.30 pm at the Astoria World Manor and a PEP Meeting on March 20th in Brooklyn. The large top photo above was published with permission by Nigel McKenna and the second photo was taken by Queens Buzz of NYC Comptroller and possible Mayoral candidate John Liu listening to concerned PS 122 parents at a United Community Civic Association meeting in Astoria.
March 11, 2013 / Astoria / Queens Neighborhoods / Queens Buzz. I attended a meeting on Thursday evening about the de-construction of the Poletti Power Plant, which is situated on the NY Power Authority site in the northwest section of Astoria. The meeting was sponsored by the United Community Civic Association [aka UCCA] and the event was held at the Augustana Lutheran Church on Ditmars Blvd in Astoria Heights.
The bottom line is that current plans call for the de-construction of the old Poletti Power plan to be completed by December 31, 2014. Current planning is underway to figure out how to approach the removal of the old plant materials. Some of the issues include routing of them via trucks through Astoria or via barge on the East River. We were told that the plant is not being demolished, but rather de-constructed in a manner similar to reverse construction. The New York Power Authority, a government agency, is managing the project.
Click here for the rest of our report, including photos of the NY Power Authority & Poletti Power Plant de-construction. By Michael Wood.
September 10, 2012 / Astoria / Queens Community Issues / Queens Buzz. On Tuesday evening September 11, there's a Community Board 1 meeting at the Astoria World Manor on 25-22 Astoria Blvd. One of the topics on the agenda is which DOT [Department of Transportation] proposal to approve, regarding changing the traffic configuration in and around the intersection of Newtown Avenue and 30th Avenue in Astoria.
According to the Queens DOT, this intersection is the site of numerous accidents, and is more dangerous than approximately 90% of all intersections in Queens. It's not difficult to understand why, as it is the nexus point for five roads: east & west on 30th Avenue, north & south on 33rd Street and northwest on Newtown Avenue [see map on next page]. The photo to your left was taken on August 25th when Newtown Avenue was temporarily converted into a pedestrian plaza.
Click here to read our report on the Newtown Plaza, in which we include related reports on other pedestrian malls in Queens, NYC and NYS.
September 10, 2012 / Astoria / Sporting Activities in Queens / Queens Buzz. On Sunday it was in the 70's and low 80's, sunny & dry. The day couldn't have been much better for a one hundred mile bike ride through all five NYC boroughs. And so it was as I headed down to the Century Bike Ride Queens rest stop in Astoria Park.
The Century Bike Ride was started by Transportation Alternatives in 1990, long before there were any real bike lanes in NYC. The first ride attracted about 200 riders, while the ride in 2012 attracted over 6,000 riders. Since that first ride, literally hundreds of miles of bike lanes have been mapped out in NYC; and the city plans to expand NYC bike lanes by about 50 more miles in 2013 - ten of which will be laid out in Queens. This expanding network of bike lanes is due in part to the work of volunteers of the non-profit organization Transportation Alternatives.
Click here to learn more about Transportation Alternatives Queens and the Century Bike Ride in Queens of 2012.
June 25, 2012 / Astoria / Queens Culture / Queens Buzz.. We tracked the weather on the Doppler radar screen via Queens Buzz [see weather link on right side bar of front page] throughout Monday. The radar successfully predicted that there wouldn't be any rain Monday night by show time, which is between 9.15 and 9.30 pm.
Nonetheless, we thought the torrential showers that plagued us Monday morning and returned briefly in the early evening, would cause people to shy away from the best Independence Day fireworks display in New York City. Not so.
May 2, 2013 / Long Island City & Astoria / Bikes & biking in Queens / Queens Buzz. On Sunday, May 5th at 7.45 am the 5 Boro Bike Tour will begin at the southern tip on Manhattan just north of Battery Park.
The bike tour is the biggest of its kind in the USA, hosting approximately 32,000 cyclists each year who travel of 40 mile route between the hours of 8 am and 6 pm on a Sunday when NYC auto traffic is diverted to accommodate the tour.
Click here for a map of the 5 Boro Bike Tour in Queens.
March 16, 2012 / Astoria / Dance in Queens / Queens Buzz. I went to watch the American Bolero Dance Company perform Tablao Flamenco on Friday night. There were eleven performances by a panoply of dancers and musicians, who sensually revived the heart and soul of ancient Andalusia and colonial Spain.
The performances were exciting to watch. The dancers' hard heels struck the wooden stage floor, in a staccato rhythm. And as the taps resounded in the air ... the cantadores emoted the melodies of Spain's Medieval past, filling the theater with vibrations of the spirit.
The dancers' fast-footed movements, belied the beautiful tranquility of their lithe upper torsos and slender arms, flowingly extended up into the air, entrapping us as we watched. In the photo to your right is Gabriela Granados, dancing the flamenco in Astoria.
Click here to read the rest of our review of Tablao Flamenco – flamenco dancing in Queens.
February 27, 2012 / Astoria / Queens Buzz. I met Kim Parshley a few years ago. Kim is a Queens resident who makes her living renting apartments and selling houses for Halvatzis Realty in Astoria. Kim has a disarming charm that fits the moniker of 'the girl next door' and she sees herself as a Matchmaker. In her youth she helped her friends make connections, and as an adult she matches apartment hunters to apartment owners.
In the summer of 2010, while working on another story, I met an older Astoria native with whom I became fast friends. He had a warm avuncular charm and a welcoming home that made me feel comfortable right away. Kim had also recently met this man, and like myself, she quickly took to him as if he was family.
Click here to read more about one of the new social networking websites in Queens.
November 24, 2011 / Queens Buzz. On Thanksgiving Day I was the witness to an event I had wanted to attend for years - the Greek Homeowners Thanksgiving Lunch. Every year, since 1989, the Greek Homeowners Association has been feeding hundreds and then growing to thousands on Thanksgiving Day. I had heard about this event numerous times, and I had been wanting to attend for years.
The Greek Homeowners Association is located along 31st Street just north of 30th Avenue in Astoria. Their quarters are in a modest two story building, which one could normally walk by without noticing, but not on Thanksgiving Day. On Thanksgiving Day, outside the Association, there were people milling about, as well as many coming and going ...
You can see a some of the action in the photo above left. Click here to view our report including a photo slide show of the Greek Homeowners Association Thanksgiving Day lunch in Astoria Queens.
August 21, 2011 / Astoria / Live Music / Queens Buzz. The Astoria Music Now venue had to be changed early Sunday morning due to weather forecast predicting severe thundershowers similar to what we saw a week ago. To make matters worse, it didn't rain Sunday until after 4 pm, and even then it was only a quick light shower … but for those who followed the Astoria Music Now musicians into the Astoria performance venues around the neighborhood ... the music played on.
Given that the venues were dispersed around Astoria, we saw far fewer performances than in prior years, so we'll link back to prior reports to give you a flavor of the concert musicians because there were a number of returning bands this year.
We started at the Quays where we saw two new comers to the festival: The Sorely Missed and Jon Christopher who performed with two new accompanists - Jason playing bass guitar and Ben Nathan percussionist [see photo above]. Click here to read more about the Astoria Music Now - rock concert in Queens.
Updated June 16, 2013 / Astoria Park Fireworks. The following report should provide the information you will need to know the time of the Astoria Park fireworks. Other events are scheduled the same night including live music.
June 30, 2011 / Astoria Neighborhood / Parks & Sports / Queens Buzz. I just returned from the Astoria Park Fireworks display - easily one of the best fireworks displays you'll find in the country. The Astoria Park fireworks are done by the world famous Grucci Fireworks company, which is a family run business that has been in the fireworks business for over a century. While the highlight of the evening was the fireworks, it's worth mentioning that thousands sat comfortably on the Great Lawn of Astoria Park and were treated to an array of beautiful music performed by the Astoria Symphony.
Click here to read our report and view dozens of photos of the Astoria Park Fireworks.
January 4, 2011 / Astoria / Queens Buzz. I just returned from a visit to a local, primarily Greek speaking, radio station in Astoria. The station is called Nexus Productions Radio, which is broadcast over the internet, as well as through the airwaves on the AM band.
I had been invited to participate as a guest on one of the station's English-speaking programs entitled Innovative Business Discussions. The weekly show has been on the air for just over a month, and it's dedicated to talking about issues associated with running a small business in Queens.
Click here to read the rest of this report, including numerous photos of the Greek speaking radio station in Astoria.
December 4, 2010 / Astoria / Queens Buzz. Leaf Fest 2010 is the annual harvest of fallen tree leaves in Queens parks along the western shorefront. Thanks to environmental activist and Leaf Fest correspondent, Jules Corkery, we have a full report about the Leaf Fest 2010 effort in Astoria Park, along with a couple of photos she provided.
Click here to read the report and view the second photo about the Leaf Fest 2010 in Astoria Park.
August 7, 2010 / Astoria / Queens Buzz. The 8th annual Musical Saw Festival was held at the Hellenic Cultural Center in Astoria. This fine art dates back to 17th century when woodcutting musicians around the world simultaneously began developing the saw as a musical instrument. In time a number of companies started manufacturing saws to cater to this part of the market.
The art form emerged in places as far away as Sweden, France and Japan; but we understand that America has emerged as the center of the art form. The Musical Saw Festival held in Astoria is the world's largest and the following report captures some of its flavor.
Click here to view a short report on the NYC Musical Saw Festival in Astoria. The photo to the left was taken by Pat Merino.
July 24, 2010 / Astoria / Queens Buzz. Dire predictions of hot & humid were about the only ones who didn't show on Saturday at the Astoria Music Now rock festival in Astoria Park. A cool dry breeze wafted in off the river making it feel more like the low 80's and dry. You can see this for yourself in the photos we took that show few people, if anyone, actually sweating it out.
Twenty-nine bands, mostly local, came out to play and thousands came out to watch and listen. Click here to view a slide show and report with photos of Astoria Music Now 2010.
May 2nd, 2010 / LIC & Astoria / Queens Buzz. It was a sunny, hot, humid morning as I biked my way over to the Queens Boro Bridge to watch 30,000 Five Boro Bike Riders descend into Queens.
None of them seemed to be having any difficulty, as they made their way up 21st Street to Astoria Park. I followed along and shot some photos and it's worth saying that 21st Street is in need of some repair. It's a rumbling road that one would expect to find in a third world nation, not along the East River waterfront of America's largest city.
Click here for a few particulars, a slide show and 5 boro bike ride photos 2010 in Astoria Park and Queens.
Astoria / April 4, 2010. In the Greek Orthodox tradition, last week was the holiest week of the year. Last Friday, I had the opportunity to photograph the parishoners of St Demetrios Greek Orthodox Church as they made a procession through the streets of Astoria to commemorate the death of Jesus Christ. The procession included a man carrying the cross, followed by altar boys, musicians, clergymen and by men carrying the the epitaphios, which resembles a casket decorated with flowers.
We'll post a full report later today or later this week, but in the meantime there's a slide show of the procession last Friday which numbered in the thousands.
Click here to view our report and photos of the Greek Orthodox Holy Friday procession in Astoria by St Demetrios parishoners.
Astoria & LIC / February 18, 2010. Some of the top designers with Queens connections collaborated with many up-and-coming Queens models to strut their stuff at the Queens Fashion Week opening night. The event took place tonight, after a week delay due to snowstorms, at the Standard Lofts, a recently renovated factory building turned residence along Northern Blvd at the foot of Steinway Street.
About twenty eight models participated in the event, walking down the runway with beautiful new clothing, designed to complement their figures and forms. The models consisted of both females and males, nearly all of whom I believe were in their twenties. This is a report of the first day of the event, which took place on a Thursday evening. Friday is the young designers night, which will be followed on Saturday with a day of exhibits with the closing runway show on Saturday evening. Click here to view the rest of our report on the opening night of the Queens Fashion Week.
January 18, 2010 / Astoria & LIC. The Queens Fashion Week casting call gathered a lot of attention this past weekend, as we estimate somewhere in the neighborhood of one hundred people responded to the possibility that they could become Queens next super model.
We paid a visit to the event to watch the next Giselle or Marcus strut their stuff. And enjoyed seeing the excitement in the contestants' eyes at their prospects for fame. The show is intended to not only provide Queens residents with an opportunity for publicity, but Queens designers as well. About ten local designers have signed up to publicize their work in the February event.
Click here to view our full report on the casting call for Queens Fashion Week.
This is a rolling summary of brief reports about green activities in Astoria and along the East River waterfront of Queens NY. To date we have a story about Queens Green Drinks and one about the Recyclefest held in Astoria in Spring 2009. Transportation Alternatives and government agencies will also be covered in this section as well as in separate reports.
East Elmhurst / September 12, 2009. I attended a memorial service at St Michael's Cemetery in East Elmhurst on Saturday commemorating the deceased of 911. The service was largely attended by the families of the deceased firemen, police officers and EMT's. I was struck by the poignancy of the day, during which family members expressed their ongoing grief and sense of loss, which they have carried with them every day for the past eight years.
This memorial service was very much a personal grieving and expression of loss. The photo to your right was taken of a firetruck standing outside the chapel at St Michael's where the memorial service was held. Click here for a full report about the 911 Memorial Service at St Michaels Cemetery in East Elmhurst.
Queens / Updated July 1, 2011. Queens won't have direct access to any public fireworks displays on Monday, July 4th, 2011 [and didn't Saturday 7/4/2009]. The Macy's 4th Of July Fireworks extravaganza is being lit on the Hudson River between Manhattan and New Jersey between 24th and 50th Streets. This is the third time [first in 2009] in about 25 years that this event will not take place on the East River where 4.5 million Queens residents and Brooklynites can also share in the view, along with the 1.6 million Manhattanites.
To find the reason for this change, get specifics on the 4th of July fireworks event, read about the Independence Day Fireworks Display in Astoria Park Thursday night June 30th [was Monday, June 29th in 2009] and find out more about other options for this 4th of July weekend, click this link to Queens Fireworks - 4th of July Fireworks in Queens NY 2011 / 2009.
Queens Green Drinks started hosting monthly events in the borough in May of 2008. Helen Ho picked up the mantle after attending one such event sponsored at the Queens Botanical Garden in September of 2007. She schedules six months of events in advance, many of which will be posted on this site each month. The following is the story of one such event, held on October 25th, 2008 at Build It Green in Astoria.
The Broadway Merchants and Professionals Association sponsored a good old fashioned street fair for Memorial Day weekend in the Astoria neighborhood of Queens NY.
Astoria / November 10, 2009. The Queens International Film Festival begins this Thursday. This year the festival will show about 300 different films including shorts, documentaries, animation, music videos as well as a complete offering of feature films. The event is scheduled to take place largely in two locations, one of which is the main center of activity – the Frank Sinatra School and the second of which is a nearby screening location, the Holiday Inn on 29th Street. Click here to view our report about the Queens Film Festival 2009.
May 2018 / Astoria Neighborhood / Queens Buzz NYC.
The Astoria neighborhood section contains stories about events, attractions, restaurants and shopping in the Astoria neighborhood of Queens. The Astoria neighborhood has numerous restaurants, both authentic ethnic and New York chic. Steinway Street and Ditmars Blvds and streets adjacent to them provide excellent neighborhood shopping venues, so residents can stroll along the boulevards and streets to find the things they're looking for and meet for lunch, drinks or dinner. Lastly, the Astoria neighorhood is teeming with life as it is home to some of the best parks in the NYC Metro area, as well a youthful nightlife. Click here to enter the fun locale called the Astoria neighborhood.
Astoria / Queens Buzz. The Astoria Events section contains stories about various musical, theatrical and other events that have or will occur in the Astoria neighborhood of Queens NY. The Astoria neighborhood is home to a number of performing arts groups, art exhibits, historical sites and schools - all of which host events on a continual basis. Astoria is also home to some of the very best parks in the NYC Metro area, including Astoria Park along the East River. Click here to enter the Astoria Things To Do & Astora Events section of Queens Buzz.
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Wednesday 1st July by "Zoom"
On : Wednesday 1st July
Time : 11:00am - 12:30pm
Via : Zoom - Register Here
Schedule 3 of the Flood and Water Management 2010, which introduced an entirely new regime for dealing with Sustainable Drainage (SuDS) on new developments in Wales, has now been in force for over eighteen months. If you develop in Wales, it is highly likely that you will have encountered this legislation and will be well aware of the uncertainties and challenges associated with it.
Join us on Wednesday 1st July 2020 at 11:00am for a webinar in which our property and planning specialists will discuss recent legal updates to the SuDs legislation in Wales, and will reflect on some of their experiences in navigating and applying the legislation to developments in Wales (including their work on a SuDs adoption agreement). They will also be joined by:
Jon Hurley, a Director at Asbri Planning who will discuss experiences to date in dealing with SuDs through the planning process; and
David Leak, a Senior Engineer at Arup who will discuss the engineering implications of the implementation of Schedule 3 on developments.
This webinar will be suitable for developers and housing associations in Wales. Please feel free to forward our invitation to any colleagues you feel would be interested.
Register now Via Zoom
Partner, Cardiff
+44 (0)29 2039 1858email
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+44 (0) 29 2039 1763email

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Wayne MarshallOn air: 8AM Sunday
Email Me | Catch Up/Podcast | RSS | iTunes
ProgrammeGood news gospel and inspirational tunes
BioRadio has been a real passion of mine from an early age. Early recollections of my radio love affair began when playing as a kid with my parent's Marantz hifi. I stumbled across, what was for me, amazing soul underground music on some local radio stations. I was hooked from then and began exploring further. My love of music gradually grew and I started purchasing vinyls from RnB to gospel. My adventure into djing also began early with one of my first 'gigs' at about 18.
I have been involved in radio as a broadcaster/producer and Dj on air since 2002 getting involved in training, producing, managing and broadcasting radio, working on Bridge AM, BANG Radio in North West London, and more recently on G Force Radio and as a presenter/producer at one of the largest Christian Radio stations in the UK, Premier Christian Media.
I regularly Dj at different events, specialising in Gospel, Classic RnB and Soulful (Gospel and Inspirational) House as part of a Good News group called KINGZ playing music for different occasions on request.
Recent Guests
Michael is one of the creators of Kickoffat3 and Jasmine Dale is from Brent's Got Talent
30/06/2019 9AM | More
Audrey has just released a new single called 'Father' This song was written to support the Gideons Orphanage in Kenya.
12/05/2019 9AM | More
Dr Angela Chair of The Violent Crime Prevention Board (VCPB) and Courtney Founder of Father2Father
14/04/2019 9AM | More
Michael is a serving Police Officer who works in Community and Youth Engagement and is passionate about supporting youth and community initiatives outside work too.
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WNTCG Single Adults Ministry
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Dr Lawrence and Dr Herbert are working on a project to prevent young people becoming involved in violent crime.
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I am doing a fundraiser concert. Whilst many of us are so grateful for the huge amounts of love, support and assistance everyone else has shown over the past three months, I felt that it was time for me to give what I have and that is my creative expressions of love.
24/09/2017 9AM | More
Angela is an acclaimed public speaker specialising on social matters and promotes equality and opportunities for the creation of opportunities for 'marginalised' members of society to be given a voice.
02/07/2017 8AM | More
Reverend Francis has been involved in ministry to men for over 28 years, some of which was spent doing district and national men's ministry in the Church of God of Prophecy.
25/06/2017 8AM | More
If you like to dance, this is for u, if you like to sing-along, this is for u, if you like meeting new people, this is for u.
31/10/2015 8PM | More
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Lou Reed's Sister Opens Up About His Childhood Struggles
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Lou Reed on East Houston, March 2011
On the eve of his posthumous induction into the Rock and Roll Hall of Fame, Lou Reed's sister, Merrill Reed Weiner opens up about his controversial childhood. Namely, the mental health issues and electroshock therapy treatments. The piece is a great mini-memoir that sets the record straight on a misunderstood time in his life.
We've re-published a few choice excerpts here, but you must read the whole megilla over at Medium.
Lou Reed passed away in 2013 from liver failure. He was 71.
At 17, the decision was made that Lou would attend New York University. My parents sent him off with pride and possible trepidation. They were about to encounter some very difficult issues with their son and the "help" they received from the medical community set into motion the dissolution of my family of origin for the rest of our lives.
Sometime during his freshman year at NYU, when I was 12, my parents went to the city and returned with Lou, limp and unresponsive. I was terrified and uncomprehending. They said he had a "nervous breakdown." The family secret was tightly kept and the entire matter was concealed from relatives and from friends. It was our private and unspoken burden. Even at 12 I knew to keep silent, and I did.
Lou was not able to function at that time. He was depressed, anxious, and socially unresponsive. If people came into our home, he hid in his room.
Despite their misgivings, my parents took a deep breath and brought Lou to a psychiatrist. Who knows what happened in the therapy setting? I only know that the treating psychiatrist recommended electroshock therapy.
Each of us suffered the loss of our dear sweet Lou in our own private hell, unhelped and undercut by the medical profession. The advent of family therapy unfortunately was not yet available to us. We were captured in a moment in time.
Our family was torn apart the day they began those wretched treatments. I watched my brother as my parents assisted him coming back into our home afterwards, unable to walk, stupor-like. It damaged his short term memory horribly and throughout his life he struggled with memory retention, probably directly as a result of those treatments.
But Lou did get better. After he recovered, he and my parents decided he should go off to Syracuse University and begin again. And he did. The rest, as they say, is history.


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Events for August 22, 2020
Events Search and Views Navigation
10:30 am
Kimberbell Club
Kimberbell Club Join us once a month from 10:30 - 12:30 and receive a dealer exclusive design from Kimberbell every single month. This month is The Grateful Heart Composition Book. Bring in you Kimberbell/ Beckie's Sewing Center flash drive, and enjoy our interactive lecture and demos. That will […]Find out more »
1:00 pm
Ruler of the Club
Ruler Club Ready to take your quilting up a notch? Ever wanted to learn to quilt with rulers? Join us once a month and get an amazing ruler from handi quilter. Personal instruction on uses for each ruler every month, with hand outs to help you succeed at home will also […]Find out more »


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Computer and Communication Terminals
Rugged Handheld Data Terminal offers bar code scanner option.
Press Release Summary:
Military grade (MIL-STD-810F) Guardian 135 combines Windows CE v5.0 OS and Intel RISC CPU PXA270 to create handheld data collection computer. Wireless connectivity is through 802.11b/g WLAN and Bluetooth, and device includes PCMCIA and SD slots for data storage and accessories. Rated IP67, it is impervious to dust, dirt, and moisture, and has also been tested to withstand 5 ft drop to concrete. Optional bar-code scanner makes Guardian 135 suitable for supply chain management applications.
Original Press Release:
Industrial Computing Introduces the Guardian 135 Rugged Handheld Data Terminal With Bar Code Scanner
The Guardian 135 is a military grade (MIL-STD-810F) ultra-rugged handheld data terminal. It combines the Windows CE 5.0 OS and Intel's high performance RISC CPU PXA270 to create a powerful handheld data collection computer. Wireless connectivity both by 802.11b/g WLAN and Bluetooth let you connect to your main computer without cables. With included PCMCIA and SD slots, you can increase data storage and add a variety of accessories, such as a GPS card, GPRS card, or RFID Card. With the optional bar-code scanner for data capture, the Guardian 135 is very suitable for supply chain management applications and many others. Tested and rated IP67, it is impervious to dust, dirt and moisture. Tested and rated to withstand a 5 foot (1.5m) drop to concrete, it will withstand the most demanding of environments.


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If you are looking to do any major DIY work in your home or at work, you are going to need the best deck paint stripper you can get hold of in order to make sure you do everything perfectly whatever you are doing. deck paint stripper is an essential part of DIY work.
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Product description
₹10405.00 per roll
Available in 3-5 working days
A fun and vibrant wallpaper design featuring matchsticks and a variety of vintage matchbook covers in an array of different styles. Shown here in various colours on a taupe background. Please request a sample for a true colour match. Pattern repeat is 64.9cm. Paste-the-wall product.
See full pattern
- Colourway
- Multi
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- Wallpaper
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- 0.52 m
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- 10.05 m
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Mast cells (MCs) are found in large numbers in lungs of patients with pulmonary fibrosis. However, the functions of MCs in lung fibrosis remain largely unknown. We assessed the role of MCs and MC protease 4 (MCPT4), the mouse counterpart of human MC chymase, in a mouse model of bleomycin (BLM)-induced lung injury. We found that levels of inflammation in the bronchoalveolar lavage and the lung, as well as levels of lung fibrosis, were reduced 7 d after intranasal delivery of BLM MC-deficient KitW-sh/W-sh mice compared with wild-type (WT) mice. Confirming the implication of MCs in these processes, we report that the levels of inflammation and fibrosis observed in KitW-sh/W-sh mice can be restored to those observed in WT mice after the adoptive transfer of bone marrow–derived cultured MCs into KitW-sh/W-sh mice. Additionally, we show that levels of inflammation and fibrosis are also reduced in MC chymase MCPT4-deficient mice as compared with WT mice at day 7, suggesting a role for MC-derived MCPT4 in these processes. Our results support the conclusion that MCs can contribute to the initial lung injury induced by BLM through release of the MCPT4 chymase.
Pulmonary fibrosis represents a broad spectrum of diseases that are characterized by different degrees of lung inflammation, excessive proliferation of lung fibroblasts, and increased lung collagen content. To date, the cellular and molecular mechanisms that initiate and maintain both the inflammatory and fibrotic processes in these diseases remain largely unknown.
Bleomycin (BLM) has been extensively used to model lung injury and fibrosis in rodents. Despite some limitations with regard to recapitulation of human disease, administration of BLM in the lung leads to secretion of proinflammatory cytokines and chemokines, recruitment of leukocytes, increased collagen production, remodeling, and fibrosis (1). Additionally, this model has clinical relevance, because BLM can cause a number of adverse events in humans, with 46% of BLM-treated patients developing lung injury and fibrosis, which is fatal in 3% of cases (2, 3).
Mast cells (MCs) are derived from hematopoietic progenitors and they mature locally in most tissues, especially those exposed to the external environment (e.g., the airways). For this reason, MCs, along with dendritic cells and macrophages, are likely to be among the first immune cells exposed to proinflammatory and toxic agents (4). Additionally, abundant numbers of MCs have been reported in the lungs of patients with various forms of lung fibrosis (5–9).
MC-released factors are potential modulators of both inflammation and fibrosis in patients with pulmonary fibrosis. Once activated, MCs can rapidly release a wide range of preformed mediators, including histamine and several MC-specific proteases, including chymases, tryptases, and carboxypeptidases (10–13). High levels of histamine have been reported in the bronchoalveolar lavage (BAL) of patients with pulmonary fibrosis (14). Additionally, expression of MC chymase is increased in human lung fibrosis (15), and two inhibitors of MC chymase (NK3201 and SUN C8077) can reduce BLM-induced experimental fibrosis in hamsters and mice (16, 17) (recently reviewed in Ref. 18). Whereas humans only express one MC-specific chymase, there are 13 known mouse chymase genes (19). Based on tissue distribution, heparin-binding properties, substrate, and cleavage specificity, the β-chymase MC protease 4 (MCPT4) appears as the main homolog to human chymase (20, 21). Moreover, MCPT4 is the main chymase in murine airways (22). However, the role of MCPT4 in models of lung fibrosis has not been reported to date.
In the present study, we show that BLM-induced lung inflammation and fibrosis are reduced at day 7 in MC-deficient KitW-sh/W-sh mice as compared with wild-type (WT) mice, and they can be restored to levels observed in WT mice after the adoptive transfer of bone marrow–derived cultured MCs (BMCMCs) into KitW-sh/W-sh mice. Additionally, by using Mcpt4−/− mice, we demonstrate that most of the MC-dependent features of this lung injury model are dependent on the MC chymase MCPT4.
Materials and Methods
C57BL/6 mice were purchased from Charles River Laboratories. Genetically MC-deficient C57BL/6-KitW-sh/W-sh (KitW-sh/W-sh) and congenic normal C57BL/6-Kit+/+ (Kit+/+) mice were provided by Dr. Salaheddine Mécheri (Institut Pasteur, Paris, France) with permission from Dr. Peter Besmer (Sloan-Kettering Institute, New York, NY). Mcpt4−/− mice on the C57BL/6 background were described previously (20). Gender- and age-matched mice were used in all experiments. Animal experimentation was conducted with the approval of the Local Ethics Committee that regulates animal research at the University of Strasbourg (Comité Régional d'Ethique en Matière d'Expérimentation Animale de Strasbourg).
BLM administration
Pulmonary fibrosis was induced by intranasal (i.n.) administration of BLM hydrochloride (BLM Bellon; Aventis, Paris, France) (0.1 mg in 25 μl PBS; 12.5 μl/nostril) under anesthesia (50 mg/kg ketamine and 3.33 mg/kg xylazine given i.p.). Control mice received i.n. administration of PBS only.
Adoptive transfer of MCs
Bone marrow cells derived from 6-wk-old Kit+/+7; >95% FcεRIα+c-Kit+) were injected i.v. into each mouse, and the recipients (BMCMCs → KitW-sh/W-sh mice) were used for experiments 12 wk later, together with age-matched Kit+/+ and KitW-sh/W-sh mice.
Total and differential cell counts in bronchoalveolar lavage fluids
BAL and differential cell counts were performed as described previously (23). Briefly, mice were anesthetized i.p. (150 mg/kg ketamine and 10 mg/kg xylazine). After semi-excision of the trachea, a plastic canula was inserted, and airspace was washed with 0.5 ml 0.9% NaCl injected with a 1-ml syringe. This operation was repeated for a total of 10 times. The supernatant of the first two washes was collected for cytokine measurements. The rest of the BAL fluid (BALF) was used for total cell counts evaluated on a hemocytometer chamber. For differential cell counts, cells were cytocentrifuged at 700 rpm for 10 min (Shandon CytoSpin 4) and labeled with Diff-Quick staining. Differential cell counts on at least 400 cells were obtained using standard morphological criteria.
KC and IL-5 (BD Pharmingen) ELISA kits were used according to the manufacturer's instructions.
Histological analysis
For histological examination of the lungs, left lobes were fixed (4% formaldehyde) and paraffin-embedded. Six-micrometer sections were cut, mounted on Superfrost glass slides (Fischer Scientific), and stained with H&E, Masson trichrome, or toluidine blue (all from Sigma-Aldrich). Toluidine blue–positive MCs were counted in three different fields for each lung section.
Lung myeloperoxidase activity and collagen measurement
Lung myeloperoxidase (MPO) activity was used as an indirect index of tissue neutrophil infiltration. Right lobes were kept frozen at −20°C until use. Lung proteins were extracted in 500 μl PBS and samples were centrifuged (15,000 × g, 15 min, 4°C). The supernatants were used for MPO activity and collagen measurement. Total soluble collagens were quantified using a Sircol assay (Biocolor Life Science Assays), according to the manufacturer's instructions. For MPO activity, hexadecyltrimethylammonium bromide (Sigma-Aldrich) and EDTA were added to 200 μl supernatant to a final concentration of 0.5% hexadecyltrimethylammonium bromide and 5 mM EDTA in PBS. Fifteen microliters was placed in test tubes with 200 μl of a buffer containing 0.03% H2O2, 0.5 mM o-dianisidine hydrochloride, and 50 mM KH2PO4 (pH 6.15). The change in absorbance was measured at 450 nm.
Statistical analysis
Results represent means ± SEM. Statistical differences were analyzed using an unpaired Student t test. A p value < 0.05 was considered statistically significant.
BLM induces a strong elevation of MC numbers in the lung
We first assessed the effect of intranasal (i.n.) administration of BLM on lung MC numbers and distribution by analyzing toluidine blue–stained lung sections of all groups of mice. Lung MC numbers were elevated in Kit+/+ mice compared with PBS-treated mice at day 7, and these numbers remained significantly elevated at day 14 (Fig. 1). Importantly, these infiltrated MCs were located in the perivascular and peribronchiolar tissue but also within the fibrotic alveolar tissue, with apparent signs of hyperplasia (Fig 1A). As expected, BLM-treated KitW-sh/W-sh mice remained MC-deficient at all time points analyzed (Fig. 1). In contrast, the number and distribution of MCs in the lungs of BMCMCs → KitW-sh/W-sh mice were similar to those observed in Kit+/+ mice (Fig. 1).
MCs contribute to BLM-induced inflammation in the bronchoalveolar space
We then studied the effect of BLM on recruitment of inflammatory cells in BALF in WT (Kit+/+) and MC-deficient KitW-sh/W-sh mice. Treatment with BLM induced a significant elevation in total cell, neutrophil, eosinophil, macrophage, and lymphocyte numbers in BALF at day 7 in Kit+/+ mice, as compared with PBS-treated mice (Fig. 2A–E). Macrophage and lymphocyte counts in BALF remained elevated at day 14 whereas neutrophil and eosinophil numbers decreased at this time point (Fig. 2A–E). The numbers of all leukocyte populations were lower at day 7 in KitW-sh/W-sh mice compared with Kit+/+ littermates, and we observed increased leukocyte numbers at day 14 versus day 7 in KitW-sh/W-sh mice (with numbers of neutrophils and eosinophils being significantly higher than those of Kit+/+ mice) (Fig. 2A–E). To assess whether the difference in responses between Kit+/+ and KitW-sh/W-sh mice was due to the lack of MCs in KitW-sh/W-sh mice or other c-Kit–related phenotypical abnormalities, we examined inflammatory cell recruitment in KitW-sh/W-sh mice engrafted with BMCMCs (BMCMCs → KitW-sh/W-sh mice). Numbers of all leukocyte populations in BMCMCs → KitW-sh/W-sh mice were very similar to those in Kit+/+ mice at days 7 and 14 after BLM administration (Fig. 2A–E).
Consistent with the previous observation, total protein concentration in BALF of Kit+/+ and BMCMCs → KitW-sh/W-sh mice was highly increased 7 d after treatment with BLM and started to decrease by day 14. In BALF from KitW-sh/W-sh mice, the protein concentration was significantly lower than in BALF from BLM-treated Kit+/+ and BMCMCs → KitW-sh/W-sh mice at day 7, but was higher at day 14 (Fig. 2F). Because there was a strong recruitment of neutrophils and eosinophils in BALF in this model (Fig. 2B, 2C), we assessed the expression of chemotactic factors for these leukocytes. BLM treatment increased levels of KC (also named CXCL1) and IL-5 in BALF at day 7 in both Kit+/+ and BMCMCs → KitW-sh/W-sh mice, and these levels returned to baseline by day 14. KC and IL-5 levels were reduced in BALF from KitW-sh/W-sh mice as compared with both Kit+/+ and BMCMCs → KitW-sh/W-sh mice at day 7. In contrast, at day 14, KC and IL-5 expression were increased in BALF from BLM-treated KitW-sh/W-sh mice as compared with Kit+/+ and BMCMCs → KitW-sh/W-sh mice (although the difference did not reach statistical significance for KC) (Fig. 2G, 2H). Additionally, we found no difference in levels of inflammation in BALF between Kit+/+ and MC-deficient KitW-sh/W-sh mice 28 d after BLM treatment (Supplemental Fig. 3A–H), a time point when the inflammation level was highly reduced in both groups as compared with days 7 and 14. Altogether, these results indicate that the early inflammation in BLM-treated mice is largely MC-dependent.
MCs contribute to BLM-induced lung inflammation and fibrosis
We then evaluated the implication of MCs in BLM-induced lung inflammation by analyzing H&E-stained lung sections of all groups of mice. In both Kit+/+ and BMCMCs → KitW-sh/W-sh mice, treatment with BLM induced a strong infiltration of leukocytes within the alveolar tissue at day 7 that was maintained at day 14 (Fig. 3A). We observed reduced leukocyte infiltration at day 7 in MC-deficient KitW-sh/W-sh mice, as compared with both Kit+/+ and BMCMCs → KitW-sh/W-sh mice (Fig. 3A). In contrast, the three groups of mice showed similar leukocyte infiltration at day 14 (Fig. 3A). Leukocyte infiltration was also similar in Kit+/+ and KitW-sh/W-sh mice at day 28, a time point when the inflammation started to resolve in both groups (Supplemental Fig. 3J). In parallel, pulmonary MPO activity, used as an indirect measurement of neutrophil recruitment, was lower at day 7 in KitW-sh/W-sh mice as compared with both Kit+/+ and BMCMCs → KitW-sh/W-sh mice, but was restored at days 14 and 28 (Fig. 3B, Supplemental Fig. 3M).
At day 7 after administration of BLM, lungs of both Kit+/+ and BMCMCs → KitW-sh/W-sh mice displayed extensive fibrotic areas with abundant collagen deposition (visualized by staining lung sections with Masson trichrome) (Fig. 4A). Consistent with these findings, total lung collagen content was significantly increased at day 7 in both Kit+/+ and BMCMCs → KitW-sh/W-sh mice compared with PBS-treated mice (Fig. 4B). Fibrosis and collagen deposition were significantly reduced in MC-deficient KitW-sh/W-sh mice compared with both Kit+/+ and BMCMCs → KitW-sh/W-sh mice at day 7. In contrast, the three groups of mice showed similar fibrosis and collagen deposition at day 14 (Fig. 4), and these levels were also similar in Kit+/+ and KitW-sh/W-sh mice at day 28 (Supplemental Fig. 3K, 3N).
Levels of the profibrotic factor TGF-β1 and the proteases matrix metalloproteinase (MMP)-2 and MMP-9 were reduced (although not significantly) in the lungs of KitW-sh/W-sh mice at early time points in our model, but they reached levels observed in Kit+/+ mice by day 28 (Supplemental Fig. 4). Altogether, our results show that MCs can significantly contribute to the early lung inflammation and fibrosis in this mouse model. However, other cell types can also mediate these features because we observed significant inflammation and fibrosis (albeit reduced compared with the levels observed in Kit+/+ and BMCMCs → KitW-sh/W-sh mice) at day 7 in MC-deficient mice, and full development of these features was observed by day 14.
MCPT4 contributes to BLM-induced inflammation in the bronchoalveolar space
Previous reports show that inhibitors of MC chymase can significantly reduce BLM-induced inflammation and fibrosis in hamsters and mice (16, 17). However, the in vivo selectivity of such drugs for MC chymase remains to be fully defined. To test the hypothesis that MCs contribute to BLM-induced lung inflammation through release of chymase, we assessed responses of mice deficient for MCPT4, the mouse counterpart of human chymase (20, 21). Numbers of total cells, neutrophils, eosinophils, and lymphocytes were reduced in BALF of BLM-treated Mcpt4−/− mice compared with WT mice at day 7 (Fig. 5A–E). Consistent with this finding, total protein concentration and IL-5 levels in BALF were also significantly reduced in Mcpt4−/− mice as compared with WT mice (Fig. 5F, 5H). In contrast, BLM-treated Mcpt4−/− and WT mice displayed similar levels of KC in BALF (Fig. 5G). Total cells, neutrophil and lymphocyte numbers, as well as IL-5 levels remained lower in Mcpt4−/− mice compared with WT mice at day 14, although the difference did not reach statistical significance for lymphocytes (Fig. 5A, 5B, 5E, 5H), and similar inflammation in BALF of WT and Mcpt4−/− mice was observed at day 28 (Supplemental Fig. 3A–H).
MCPT4 contributes to BLM-induced lung inflammation and fibrosis
In contrast with two previous reports (22, 24), we found significantly increased numbers of MCs in the lungs of control (PBS-treated) Mcpt4−/− as compared with WT mice (Fig. 6A). MC numbers remained more elevated in the lungs of Mcpt4−/− mice at days 7 and 14 after BLM administration (Fig. 6A, 6B). Despite these increased lung MC levels, leukocyte infiltration was reduced at days 7 and 14 (neutrophils and lymphocytes) in BLM-treated Mcpt4−/− mice compared with WT mice (Fig. 5A, 5B, 5E). Additionally, pulmonary MPO activity was reduced at days 7 and 14 in Mcpt4−/− mice compared with WT mice (although the difference did not reach statistical significance at day 14) (Fig. 6C). Finally, fibrosis and collagen deposition were also reduced at day 7 in Mcpt4−/− mice compared with WT mice (Fig. 6A, 6D), but no significant differences were observed at day 14 (Fig. 6D and data not shown). Levels of lung inflammation and fibrosis were similar in WT and Mcpt4−/− mice at day 28 (Supplemental Fig. 3I–N). Moreover, WT and Mcpt4−/− mice displayed similar levels of the profibrotic factor TGF-β1, the proteases MMP-2, MMP-9, and the resolvin RvD1 at all time points analyzed (Supplemental Fig. 4). Altogether, our results show that most of the early MC-dependent features of this mouse model are dependent on MCPT4.
In the present study, we used genetically MC-deficient KitW-sh/W-sh mice and engraftment of these mice with BMCMCs to demonstrate that MCs can amplify the acute lung injury induced by administration of BLM. We further show that the MC-specific chymase, MCPT4, contributes to the ability of MCs to amplify most features of this model.
We showed that BLM treatment increases the number of MCs in the lung. MCs were located in the perivascular and peribronchiolar tissue, where they exhibited signs of hyperplasia. MCs were also found in the alveolar tissue of BLM-treated mice, where they appeared as mainly located in the fibrotic areas. These results are in agreement with the increased number of MCs found in patients with various forms of lung fibrosis (6–9, 25), and they confirm previous findings in mice and rats (26, 27) using the same BLM model.
Inflammation, fibrosis, and collagen deposition appeared to be MC-dependent features at 1 wk after i.n. administration of 0.1 mg BLM, as their levels were significantly lower in MC-deficient KitW-sh/W-sh mice as compared with Kit+/+ mice and could be restored to WT levels after adoptive transfer of BMCMCs into KitW-sh/W-sh mice. However, significant levels of inflammation and fibrosis were still present in KitW-sh/W-sh mice at day 7, and full development of the pathology could be observed after 2 wk, showing that other cell types can also mediate inflammation and fibrosis and overcome the role of MCs at a longer time period in this model.
These results might explain, at least in part, why conflicting findings on the role of MCs in models of lung fibrosis have been reported. O'Brien-Ladner et al. (28) showed decreased pulmonary fibrosis induced by BLM in mutant mi/mi mice that are profoundly deficient in MCs. However, because these mice also lack basophils, NK cells, and functional osteoclasts (29), definitive results implicating MCs could not be achieved by this study. Brown et al. (30) showed impaired lung inflammation and collagen deposition in KitW-sh/W-sh mice in a model of pulmonary fibrosis induced by instillation of silica; however, the role of MCs was not confirmed by adoptive transfer of BMCMCs in this study. In contrast, two other reports failed to show any implication of MCs in BLM-induced fibrosis using MC-deficient WBB6F1-KitW/W-v mice (31, 32).
Although WBB6F1-KitW/W-v and KitW-sh/W-sh mice are both deficient in MCs owing to dysregulations of the c-kit gene, several important phenotypic differences between these mice exist. For example, WBB6F1-KitW/W-v mice are anemic and sterile and have reduced numbers of neutrophils (33–36) and basophils (35, 37, 38). In contrast, C57BL/6-KitW-sh/W-sh mice are neither anemic nor sterile, and they have increased numbers of neutrophils (34–36, 39) and basophils (35). Other groups have already noticed that conclusions made using genetically MC-deficient mice highly depend on the mouse strain background, the nature of the mutation resulting in a MC deficiency, and the severity of the model used (35, 40). For example, MC-deficient C57BL/6-KitW-sh/W-sh mice, but not WBB6F1-KitW/W-v mice, develop experimental Ab-dependent arthritis (36, 41). Piliponsky et al. (35) showed that MCs can promote survival in a model of sepsis of moderate severity, but they had no detectable effect or even opposite effects on survival (depending on the mouse strain background) in a more severe sepsis model. In agreement with these findings, we found no difference in leukocyte numbers in BALF (Supplemental Fig. 1), lung inflammation, and fibrosis (Supplemental Fig. 2) between Kit+/+ and KitW-sh/W-sh mice when using a higher dose of BLM (0.3 mg).
Interestingly, numbers of neutrophils and eosinophils, as well as total proteins and IL-5 concentrations, were significantly higher in KitW-sh/W-sh mice compared with Kit+/+ or BMCMCs → KitW-sh/W-sh mice at day 14 after treatment with 0.1 mg BLM, suggesting that MCs might also be implicated in the resolution phase in this model. Indeed, such potential anti-inflammatory or immunosuppressive effects of MCs have already been observed in mouse models of skin graft tolerance (42–44), contact hypersensitivity to UV-B irradiation or haptens (45, 46), and chronic allergic dermatitis (47). Such a biphasic effect of MCs could also contribute to the heterogeneity in reports of the role of MCs in BLM-induced lung inflammation (28–32). However, we found no difference in levels of inflammation in BALF and lung between Kit+/+ and MC-deficient KitW-sh/W-sh mice 28 d after BLM treatment, a time point when the inflammation level was highly reduced in both groups as compared with days 7 and 14. In this less inflamed, more fibrotic phase of the model, we also observed no difference in levels of lung fibrosis and collagen deposition between Kit+/+ mice and KitW-sh/W-sh mice, as well as similar levels of the resolvin RvD1, the profibrotic factor TGF-β1, and the proteases MMP-2 and MMP-9 that were reduced (although not significantly) in the lungs of KitW-sh/W-sh mice at early time points. Altogether, our data indicate that MCs can modulate the early inflammatory phase, but they play only a limited role in the development of late fibrosis in this lung injury model.
Consistent with the role of MCs observed at day 7 in our study, two independent reports indicated that administration of the chymase inhibitors NK3201 or SUN C8077 dose-dependently inhibits BLM-induced lung fibrosis in mice (16, 17). Indeed, MC chymase expression is increased in the lungs of humans with idiopathic pulmonary fibrosis (15). More recently, Takato et al. (48) showed that the chymase inhibitor TY51469 also attenuates silica-induced pulmonary fibrosis in mice. However, the specificity of these inhibitors remains to be fully characterized in vivo. We report in the present study that mice deficient for MCPT4, the main chymase in murine airways (22) and closest homolog to human chymase (20, 21), have reduced lung inflammation at day 7 and, to a lesser extent, at day 14 after i.n. administration of 0.1 mg BLM compared with WT mice. Most of the MC-dependent features of this model (such as production of IL-5 and collagen or the increase in neutrophil and lymphocyte numbers) also appear to depend on MCPT4. However, we did not detect any difference in KC levels between WT and Mcpt4−/− mice, suggesting that some MC-dependent features occur in a MCPT4-independent manner. Similarly to MC-deficient KitW-sh/W-sh mice, levels of collagen deposition and fibrosis were reduced at day 7 in Mcpt4−/− mice, but we observed full development of fibrosis by days 14 and 28. Altogether, these data indicate that MCs and MCPT4 can regulate the early inflammatory phase but not the fibrotic phase in this lung injury model.
In agreement with the proinflammatory role for MCPT4 in this model, MCPT4 has been shown to play deleterious effects in models of abdominal aortic aneurysm (49), glomerulonephritis (50), or arthritis (51). However, recent evidence also indicates that MCPT4 can have protective functions. For example, MCPT4 can reduce the toxicity of certain venoms (52), as well as the extent of inflammation in models of allergic airway inflammation (22, 24), sepsis (53), posttraumatic brain inflammation (54), or danger-induced inflammation (55). Very recently, protective effects of MCPT4 were also reported in a model of renal tubulointerstitial fibrosis (56). As suggested previously, such divergent roles for MCPT4 may reflect differences in the types and/or availability of substrates, about which little is known to date (53).
In conclusion, we show in this study that MCs and the MC-specific chymase MCPT4 can mediate acute lung inflammation and injury induced by administration of a low dose of BLM in mice. We found that the early inflammatory response to BLM highly depends on the presence of MCs and its chymase MCPT4, but both MC-deficient and MCPT4-deficient mice ultimately develop levels of inflammation and fibrosis similar to those observed in WT animals. Although particular care should be taken in extrapolation of these results to humans, our findings indicate that the sole use of chymase inhibitors, or other potential drugs targeting MC activation, is unlikely to result in significant clinical benefit in the treatment of pulmonary fibrosis. However, our data raise the possibility that these drugs could be used in combination with antifibrotic agents to improve the efficiency of such therapies.
The authors have no financial conflicts of interest.
We thank Drs. Janet Kalesnikoff and Thomas Marichal for critical reading of the manuscript.
The online version of this article contains supplemental material.
Abbreviations used in this article:
- bronchoalveolar lavage
- bronchoalveolar lavage fluid
- bleomycin
- bone marrow–derived cultured mast cell
- i.n.
- intranasal
- mast cell
- mast cell protease 4
- matrix metalloproteinase
- myeloperoxidase
- wild-type.
- Received April 1, 2013.
- Accepted December 16, 2013.
- Copyright © 2014 by The American Association of Immunologists, Inc.


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U.S.-led strikes pound Islamic State in Iraq, kill 250 fighters – Reuters
U.S.-led coalition aircraft waged a series of deadly strikes against Islamic State around the city of Falluja on Wednesday, U.S. officials told Reuters, with one citing a preliminary estimate of at least 250 suspected fighters killed and at least 40 vehicles destroyed.
If the figures are confirmed, the strikes would be among the most deadly ever against the jihadist group. The officials spoke on condition of anonymity to describe the operation and noted preliminary estimates can change, as reported by Reuters.
Read alsoCIA director says Islamic State still serious threat – ReutersThe strikes, which the officials said took place south of the city, where civilians have also been displaced, are just the latest battlefield setback suffered by Islamic State in its self-proclaimed "caliphate" of Iraq and Syria.
As UNIAN reported earlier, the city of Fallujah was "fully liberated" from Islamic State group militants on June 26, after a more than month-long military operation.


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NBPA Press Release after the Special Case Hearing for Superintendent Robyn WilliamsPosted on 17/03/2020 | No CommentsA proud Black female Metropolitan police officer, her uniform adorned with medals, shows off police trainees to the Asian heritage mayor of her city, London – one of the most diverse cities in Western Europe. This is Robyn Williams who for more than 30 years served the communities of Nottinghamshire and London, going above and beyond her duty. She has drawn public confidence for her work with the survivors and families of the Grenfell tragedy. Unfortunately as Robyn rose through the ranks from Constable to Superintendent the Met has kept looking for reasons to discredit her exemplary service and success […]


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– SECONDARY – All Regions Held on SEPTEMBER 25, 2011 Released on NOVEMBER 16, 2011 Page: 40 of 264 Seq. N a m e 1901 BENGAN, RHEA ACEPCION 1902 BENIGNO, KRIZEL ELUMACAS 1903 BENITEZ, CHERRY IGNAO 1904 BENITEZ, JINKY BELEN 1905 BENITEZ, MARY JOY GO 1906 BENITO, CHARLES CASLATAN 1907 BENITO, MARY GRACE TEOFILO 1908 BENITO, RAMIRSON ERGUIZA 1909 BENNAGEN, MARKIMSON TOMAS 1910 BENNANG, JONALINE ANGYAAN 1911 BENOLIRAO, GEOSELIN JANE BIBOSO 1912 BENSIG, JO-ANN REGINO 1913 BENTAYAO, QUIMBERLY AMPAN 1914 BENTING, ROEL SAPLAD 1915 BENTRES, JANE TAWARAN 1916 BENTULAN, RICCI MAGLANGIT 1917 BENUSA, REYNOSA POSTRERO 1918 BERADOR, KAREN CHRESTY GEVANA 1919 BERAN, CLARISSA PAGULAYAN 1920 BERCERO, RANDY PADERNAL 1921 BERCO, MC JEM VILLORENTE 1922 BERDOS, FLORENCE BALIBREA 1923 BEREDO, MARICRIS LOMIO 1924 BEREN, MA CATHERINE CORRAL 1925 BERENDEZ, ARLYN OLARITA 1926 BERGADO, MICHAEL JOHN ARBOSO 1927 BERGONIA, RICHARD MAUN 1928 BERGONIO, GERARD DEL MUNDO 1929 BERGULA, ALDRIK GONITO 1930 BERING, JIMA GRACE ROSALES 1931 BERIÑA, ANGELICA PAUYO 1932 BERMAS, HERBERT BONEO 1933 BERMAS, MELISSA NOEMI MIRANDA 1934 BERMEJO, ANGHELITO HUGO 1935 BERMEJO, CHRISTY JOY SABALOSA 1936 BERMEJO, JAYRON DE LUCAS 1937 BERMEO, ELSIE BALDERA 1938 BERMEO, MARY GRACE JINKY SIDUTAN 1939 BERMIDO, RODEL REY SANTAOLAYA 1940 BERMILLO, IRENE BEA 1941 BERMUDEZ, CRISTINA TADENA 1942 BERMUDEZ, JOVELYN GANZON 1943 BERMUDEZ, JUAN JR LUMACAD 1944 BERMUDEZ, LORENZA DELOS REYES 1945 BERMUDEZ, NIMPHA SAGAO 1946 BERMUDO, DHAREL CANDILARIA 1947 BERNABE, CATHLEEN MONGOLIAN 1948 BERNABE, JAY ANN SELLADORA 1949 BERNABE, JOHN GLENN REMERATA 1950 BERNABE, MARILYN DOLOR Roll of Successful Examinees in the L.
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When you're a student at Central College, there is no shortage of exciting things to do — both on and off campus! To help you discover some fun things to do off campus, here's a list of activities to do in Pella!
Lake Red Rock
Lake Red Rock is Iowa's largest lake and is filled with a bunch of recreational activities. Located a few miles away from Central's campus, many students go to the beach, use the trails for running or choose one of the other outdoor activity options at Red Rock!
Volksweg Trail
The Volksweg Trail is a 14-mile trail that spans from the edge of Central's campus all the way to Lake Red Rock. It's a great place to walk, run or bike on a nice day!
Cordova Observation Tower
Lake Red Rock also is home to Cordova Observation Tower — a huge tower where guests can climb to the top and are welcomed by an amazing view. It's free to use and great exercise walking to the top.
If you need a cheap and easy way to get around town, you'll want to use VeoRide. VeoRide is a bike share program with stations all around Pella. Just look for the turquoise bikes on campus or around Pella. Then you can pull out your phone, open the VeoRide app and scan the code on the handlebars to get on your way. Everything in town is easily bikeable or walkable, so you can explore whenever and wherever you like!
George's Pizza
One of Pella's most popular restaurant is George's Pizza. The pizza is incredible, and they also serve insanely good pasta. Don't forget to grab some free ice cream on your way out!
El Charro
El Charro is a popular Mexican restaurant in town and many Central students' favorite place to go to grab a bite!
Yamato is Central students' go-to sushi place. They serve a variety of sushi and other Asian cuisine Central students love!
Coffee Shops
There are several amazing coffee shops students frequent, including Smokey Row, The Brew, The Sanctuary and The Perk. Students go there to study, catch up with friends or grab caffeine on the go!
Town Square
Pella's town square is only a couple of blocks away from campus and is filled with restaurants, coffee shops, bakeries, boutiques and more with a park in the center of it all.
Tulip Time
Tulip Time is an annual festival that takes place the first week of May. Tulip Time celebrates Pella's Dutch heritage. Over the course of three days, there are parades featuring local participants, stands selling the most delicious Dutch food and a whole heap of fun! Plus, all the festivities are just a short walk from campus, so you won't miss out!
Christmas in Pella
The holiday season is a special time of year, and in Pella it gets even more festive! Every year the town square is decked out in holiday decorations, culminating in a massive tree in the Tulip Tower that's picture-perfect for your holiday greeting card.
These are just a few examples of the many things to do in Pella. There's so much more to see, do and experience. All you have to do is get out there and explore!
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About the Author
Hi! My name is Cooper Vittetoe '21 and I am a communication studies major from Waukee, Iowa. I am a member of the A Cappella Choir and Chamber Singers, a social media coordinator for the A Cappella Choir, and I have a work-study job in the Central Admission Office. Outside of class, you can find me grabbing a bite to eat at Fred's, singing with my friends in the choir or taking pictures of Central and the city of Pella.


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I just want to say "THANKYOU " FOR ENLIGHTENING ME on this subject. There's much food for thought. i'm going to do some more research on this situation myself. Thanks again for the input !
I must also point out:Read and pay attention to Neil Obstat's responses to Cosmas in this thread.Cosmas might have his heart in the right place, but he is mistaken about what "Transubstantiation" means. He is not a theologian, having never attended Seminary or learned Thomistic philosophy (substance and accident), so it's understandable that he is ignorant about this particular theological point. I'm sure he's not alone here.I hope that he, and anyone else, reads Neil's posts for a clear and thorough explanation of the matter.A small sample of Neil's excellent, theologically sound exposition of the topic:
.I'd like to know what's going on here in other chapels because I know one doctor who says that no amount of gluten is okay..He says to be gluten free and to lose the effects due to gluten intolerance you have to remove ALL the gluten from your life.The pet food in the house must be gluten free, etc., etc., etc.
.This doctor is a quack.
.Which doctor?
That presumes that such catering to special needs is legitimate. I honestly don't know, not having studied this in a professional manner.
NEIL OBSTAT,I was researching and found this can you explain it to me. Doesn't it mean what it says ? COUNCIL of TRENT, SESSION 13 CANON 4 " If anyone shall say that in the Most Holy Sacrament of the Eucharist, the substance of the bread and wine remains, together with the Body and Blood of Our Lord Jesus Christ," Let Him BE ANATHEMA ."
.NEIL OBSTAT,I was researching and found this can you explain it to me. Doesn't it mean what it says ? COUNCIL of TRENT, SESSION 13 CANON 4 " If anyone shall say that in the Most Holy Sacrament of the Eucharist, the substance of the bread and wine remains, together with the Body and Blood of Our Lord Jesus Christ," Let Him BE ANATHEMA .".STANLEY N ,My point was getting back to gluten in the bread, the bread and wine are no longer bread and wine after the Consecration. I still don't know why if its been changed the substance ,how can someone have an intolerance to it. Could it possibly be in their mind , Thinking about the Eucharist being made out of Bread ?
.At the SSPX chapel in San Antonio, a couple years ago, one man received the Precious Blood during Mass on Sunday. He had some kind of allergy or intolerance. The priest would administer to him from a small chalice kept in the tabernacle. It really was quite a spectacle. It's a shame Trad priests don't have more time, to say more Masses for each area per week, so that individuals like this could have their special needs met at a Mass with less attendance.That presumes that such catering to special needs is legitimate. I honestly don't know, not having studied this in a professional manner.I do know that we had a parishioner who was gluten intolerant, but she never got to receive Communion. Not from a gluten free or low-gluten host, and not from the chalice. This was under Bp. Zendejas.
.Well, the general principle is that Catholics (well disposed, of course) have a right to sacraments. Sacraments are often offered as a "special need," e.g. when a priest travels a hundred miles to give last rites. Thing is, that happens outside of mass and no one sees it, so it isn't a spectacle. Another example, again less spectacular, are the elderly who cannot kneel for Holy Communion. I am tempted to think that catering to "special needs" is not just legitimate, but that priests are generally bound to do so. It should be done, when it can be done, with little spectacle. But even if it can only be done with "spectacle" it should be done. Well disposed Catholics, even celiacs, have a right to the sacraments, a right which definitely transcends the sensitivities of those who seek scandal in Holy things..I knew some people who were not celicas, but who (I think) were very close to being celiacs. To my knowledge they did not receive any special Host, nor did they receive a "Chip", but if I recall correctly they had to drink copius amounts of water soon after receiving Holy Communion and even at that it made them quite uncomfortable. I think.
Why was this a spectacle? There is a lady at my church who will suffer vomiting and diarrhea if she consumes wheat. Father has her come up after the rest of us finish Communion and receive from the chalice. Between praying and all the people moving back to their pews it's only rare that I even notice her.
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