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Retail News
Macy's to welcome back crowds for Thanksgiving Day ParadeNPR 09/09/2021
Macy's annual Thanksgiving Day Parade was a virtual event last year as the retailer worked with public health officials to keep its normally large crowds safe from COVID-19. The retailer has announced that it will welcome back throngs of New Yorkers and out-of-towners to this year's parade. All participants in the parade will need to be vaccinated and wear face masks to take part. Macy's has said that it will cut down on the number of participants to around 1,600 as a health precaution, down from its typical 8,000.
Check out RetailWire's Engaging Online Discussions Featuring Our Exclusive Braintrust!

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The latest round of FBS realignment could hinge on a school that's not even in FBS
We've reached the point of the latest round of realignment where the aftershocks of Texas and Oklahoma's impending move to the SEC are now being felt a level below FBS.
This latest round has proven to be a repeat of all the other rounds: the, uh, stuff runs downhill. The SEC poached the Red River rivals, so the Big 12 grabbed Cincinnati, Houston and UCF from the American (plus BYU), and now the American is set to nab Charlotte, Florida Atlantic, North Texas, Rice, UAB and UTSA from Conference USA.
This is the point where Conference USA would ordinarily pluck the four most attractive options from the Sun Belt, the Sun Belt would compel some Big South or SoCon schools to move up to FBS, and round and round we'd go.
Except now the Sun Belt appears to be ready to go on the offensive.
There are many moving pieces darting all across this chessboard, but James Madison is the only school to appear on both C-USA and the Sun Belt's wish lists. The same James Madison that is not currently in FBS.
To be sure, JMU has the profile of an FBS school. With 21,000 undergrads, the Harrisonburg, Va., based school plays in a 25,000-seat stadium and its $10.6 million in football revenue (2018-19) was the highest in FCS. Its $50+ million budget would be among the tops in the Sun Belt or C-USA right now. The Dukes were a target of realignment way back in 2013. JMU said no then, but in doing so they eased the door shut, they didn't slam it.
Conference USA's current roster, less the six defectors, is eight schools with about as much in common as Billy Napier and Billie Eilish, stretching from Huntington, W. Va., to Miami, to El Paso.
If the Sun Belt manages to sway Southern Miss, Marshall, Old Dominion and James Madison away from Conference USA, C-USA would be left with five schools: Western Kentucky, Middle Tennessee, Florida International, Louisiana Tech and UTEP.
Meanwhile, the Mountain West is not expanding.
It's not clear where C-USA would go from there. Liberty, UMass and New Mexico State would likely say yes, but then what? You've made your far flung conference even more far flung without making it all that much more attractive to a TV network.
No good options remain if and when your conference roster drops to five schools, so C-USA's first course of action is crystal clear: don't drop to five schools. If it is to survive in anything resembling a healthy state, Conference USA may just have to get to James Madison before the Sun Belt does.


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HealthDay Reporter
MONDAY, Dec. 13, 2021 (HealthDay News) – Gene therapy that could provide a lasting cure for sickle cell disease continues to show success through the third wave of patients, the researchers report.
LentiGlobin therapy restored normal blood function in 35 sickle cell patients who had a single procedure, according to Clinical trial findings published Dec. 12 in New England Journal of Medicine.
All patients now produce stable amounts of normal red blood cells containing healthy hemoglobin, said lead researcher Dr. Julie Kanter, director of the University of Alabama at the Sickle Cell Adult Clinic in Birmingham.
In addition, they have not suffered the severe episodes of pain that come with sickle cell disease, she said.
"It's the beginning of a new life" for these patients, Kanter said.
About 49 patients have been treated with LentiGlobin so far, according to the gene therapy manufacturer, a pharmaceutical company. Bluebird Bio.
Sickle cell disease affects a person's red blood cell shape. Usually, these cells are disc-shaped and flexible enough to move easily through blood vessels.
The red blood cells of a person with sickle cell disease are crescent-shaped, sickle-shaped. The cells are stiff and sticky, and cause pain episodes and other health problems when they accumulate in different parts of the body.
These problems are caused by a substance called hemoglobin, which is part of the red blood cells that carry oxygen to tissues throughout the body, Kanter explained. A faulty gene causes the body to produce defective hemoglobin which distorts the shape of blood cells.
"They still carry oxygen, but they don't retain oxygen, and when cells release oxygen, hemoglobin intertwines with its hemoglobin counterparts, causing cell and sickle deformity," Kanter said.
In this therapy, Stem cells they are removed from the bone marrow of the person who produces the blood. Laboratory technicians expose them to a virus that inserts a healthy copy of the defective hemoglobin gene into them.
As this happens, the patient's remaining bone marrow is killed chemotherapy. Laboratory-repaired stem cells are then implanted and begin to produce healthy hemoglobin.
"This is like working a bone marrow transplantation into yourself, "said Dr. Lewis Hsu, chief medical officer of the American Sickle Cell Disease Association.
Clinical trial update published in NEJM – and presented at the same time at the meeting of the American Society of Hematology in Atlanta – said that even three years after their treatment, the third wave of patients LentiGlobin showed a number of promising signs that indicate a permanent cure:
- Almost all of their red blood cells contain healthy hemoglobin, instead of defective hemoglobin caused by defective genes.
- Their red blood cells break down at a normal rate; sickle cell disease usually causes cells to break down much faster.
- No one experienced episodes of severe pain that brought them to the emergency room; before treatment, they usually suffered more than three a year.
"This is a huge improvement, because many of these people had multiple events before this transplant, where they were in the hospital or in the emergency room because of these horrible painful events," Kanter said.
Researchers continue to monitor patients for the ultimate indicator of true healing – the long-term health of their organs. The sickle cell puts stress on the kidneys, lungs, heart and brain, and we hope that LentiGlobin treatment will prevent organ damage caused by the disease.
"We just don't know it yet because it takes a lot of time to gather that information, but it's really exciting," Kanter said.
The sickle cell disease community is striving for the success of LentiGlobin, Hsu said.
"This is the gene therapy that is now the longest for sickle cells," he said.
However, Hsu pointed out that there are security issues that still need to be ironed out by the procedure.
One of the first patients treated with LentiGlobin developed leukemia about five years later and died, Hsu said.
Another paper published in new NEJM shed some light on her death, explaining that LentiGlobin did not directly cause her leukemia. Instead, it appears to be in some way caused by her sickle cell disease combined with the transplant procedure.
Leukemia was a concern over this therapy, Kanter said.
"We worry that when a virus enters a new gene, it puts it somewhere it shouldn't," she said. "It didn't do it. It didn't happen. It wasn't related to LentiGlobin itself at all, but we think it was related to the stem cell transplant process."
Since that first wave of patients, Kanter said, researchers have changed the way stem cells are collected and the way the virus is introduced to them.
Researchers hope the changes will prevent the process that caused the leukemia. "We hope we've prevented additional stress on the bone marrow," Kanter said.
Combined, these two papers "show really good results." Hsu said it is now a matter of understanding what risks gene therapy can pose.
"The fact that this has not yet been explained still makes us look at the success of this and realize that there are still risks in gene therapy, there are still risks in clinical trials," he added.
Kanter expects LentiGlobin to move to approval from the U.S. Food and Drug Administration in the next few years. The drug is likely to be expensive, given the cost of therapy, chemotherapy, and weeks spent in the hospital.
"Unfortunately, I think it will be very expensive for a long time to come. The next steps are how to make it easier and cheaper and more affordable," Kanter said.
More information
The American National Institutes of Health has more about sickle cell disease.
SOURCES: Julie Kanter, MD, Director of the Sickle Cell Adult Clinic and Associate Professor, Department of Hematology and Oncology, University of Alabama at Birmingham; Lewis Hsu, MD, PhD, Chief Medical Officer, Sickle Cell Disease Association of America, Hannover, Md .; New England Journal of Medicine, 12 December 2021, online; presentation, meeting of the American Society of Hematology, Atlanta, December 12, 2021.
Source link


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Could be used across all classes in a variety of ways.
E.g. ask students to produce a report for a retailer; Ask students to find the mean of each data set; ask students to put the data into stem and leaf diagrams, boxplots and interpret.
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A collection of worksheets and activities in a range of styles. Some activities are pair work/ lead to class discussion. Includes a wordseach. Also a handling data Project - which is the fittest form.
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By James Miller
In the course of his lifetime, Dante was once condemned as corrupt and banned from Florence on discomfort of loss of life. yet in 1329, 8 years after his dying, he used to be back viciously condemned—this time as a heretic and fake prophet—by Friar Guido Vernani. From Vernani's inquisitorial perspective, the writer of the Commedia "seduced" his readers via supplying them "a vessel of demonic poison" combined with poetic fantasies designed to wreck the "healthful fact" of Catholicism. due to such pious vituperations, a sulphurous fume of unorthodoxy has over and over clung to the mantle of Dante's poetic status. the first severe objective of Dante & the Unorthodox is to ascertain the classy impulses at the back of the theological and political purposes for Dante's allegory of mid-life divergence from the papally prescribed "way of salvation." Marking the septicentennial of his exile, the book's eighteen severe essays, 3 excerpts from an allegorical drama, and a portfolio of fourteen modern artistic endeavors tackle the difficulty of the poet's conflicted relation to orthodoxy. by way of bringing the unorthodox out of the world of "secret things," via uncensoring them at each flip, Dante dared to oppose the censorious regime of Latin Christianity with a transgressive zeal extra threatening to papal authority than the demonic hostility feared by way of Friar Vernani.
Read Online or Download Dante & the Unorthodox: The Aesthetics of Transgression PDF
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Extra resources for Dante & the Unorthodox: The Aesthetics of Transgression
Sample text
Standing in front of the same stone, just behind the poet, is a small dark hooded figure whose face is partly obscured by the busy workmen milling about at the construction site. His Dominican habit, a clue to his identity, must have raised many an eyebrow when the painting was first unveiled. If he is indeed who he appears to be—the renegade preacher Girolamo Savonarola, burnt at the stake a decade before the Disputa was painted—then his brooding presence in the scene reveals the Holy Father's retroactive power to restore intellectual 28 INTRODUCTION Raphael, Parnaso (1510–11), Stanza della Segnatura, Vatican.
That is hardly possible for moderns anyway. How can any of us suspend both belief and disbelief, as Eliot would INTRODUCTION 43 have us do, without wiping out the discursive contents of our minds? Such a state is only possible to attain in Dante's poetic universe at the moment of oltraggio, but even then the transcendence of theological discourse does not even necessitate the isolation of subsequent literary judgment from religious and aesthetic interest in the problem of orthodoxy, an issue which will always be relevant to a poem in which a doctrinally marginal poet stages his own orthodoxy test and passes it (of course) with flying colours.
His Dominican habit, a clue to his identity, must have raised many an eyebrow when the painting was first unveiled. If he is indeed who he appears to be—the renegade preacher Girolamo Savonarola, burnt at the stake a decade before the Disputa was painted—then his brooding presence in the scene reveals the Holy Father's retroactive power to restore intellectual 28 INTRODUCTION Raphael, Parnaso (1510–11), Stanza della Segnatura, Vatican. Above the doorway sits Apollo playing a violin. Dante poeta, the eighth figure on Apollo's left, joins Homer and Virgil (happily harrowed from Limbo) to complete the triad of epic poets on the summit of humanist culture.


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Added Time: The Irish Times Sports Podcast
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Series home•Feed
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By Added Time: The Irish Times Sports Podcast. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.
Every Monday, Malachy Clerkin and Pat Nugent talk sport - GAA, rugby, football and more - with their Irish Times colleagues and special guests. Supported by Fitbit.
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Choose a cheerful golden retriever puppy
A puppy that is withdrawn, that is not irritated and happy, or that is sick or not able to socialize properly within the litter. Such puppies will later very likely grow into an insidious or distrustful dog and will be very ungrateful for training, maintenance and overall life together.
Examine the puppy's head
This is a very simple method to establish a dog's health. The nostrils must be cool, moist, clean and without secretions. Eyes too. Look at the ears and determine if they are scratched (puppies are often injured in the game) or dirty. The gums need to look clean and a healthy pink color.
Check the dog's breathing
If you notice any squeaking, scratching in the air flow, it is probably a sick puppy.
Compare the nutrition of the puppies within the litter
Those who are physically smaller are not able to fight for food, but are slightly behind those puppies that dominate. Avoid taking puppies from litters with visible ribs or from a litter where all dogs are generally malnourished.
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Specific Technologies announces discovery of a CRE signature in E. coli. growing in culture
MOUNTAIN VIEW, California, March 2, 2017 — Specific Technologies announces discovery of a CRE signature in E. coli. growing in culture, to be presented at ECCMID global summit in April
Specific Technologies, which has developed a new microbiology diagnostic paradigm combining detection and identification (ID) of microorganisms growing in culture, announces today the discovery of a unique signature for deadly Carbapenem-resistant Enterobacteriaceae (CRE) strains of E. coli. Specific will present its findings at the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), on April 24, 2017, in Vienna, Austria.
Based on a printed, disposable volatile-sensitive sensor array, Specific's diagnostic system, SpecID, obtains a strain-specific "fingerprint" of bacteria as they grow in culture, combining detection, Gram status and ID into one rapid step. As will be detailed in a presentation at ECCMID, this fingerprint is predictive of the CRE phenotype in E. coli. in over 90% of the cases tested thus far. This predictive correlation, if validated in clinical studies, could provide caregivers an unprecedentedly early and desperately needed warning of CRE in E. coli.- mediated blood infection, one of the deadliest human disease conditions. Blood infection is by far the leading cause of death in hospitals1 , and E. coli. is among the most prevalent causes of blood infection in the US.
Such an early CRE signature could offer an indication that the infection is highly antibioticresistant at the earliest possible time, during primary culture, allowing doctors to react days earlier than is possible with current methods, rapidly shifting therapy away from ineffective broad-spectrum antibiotics to an effective alternative. The CRE indication could also prompt appropriate measures to avoid transmission to other patients and caregivers. Specific believes that this is the first report of any diagnostic system which can detect CRE during primary culture.
"We believe that this discovery could have, if validated, substantial and broad clinical impact," said Dr. Paul Rhodes, Chief Executive Officer of Specific Technologies. "We invite researchers with interests ranging from clinical care of blood infection to the metabolomics of drug resistance mechanisms to visit our poster, interact with our scientists and visit our booth."
The abstract will be presented at ECCMID in Vienna, Austria, which will be held from April 22- 25, 2017 at the Reed Exhibitions Messe Wein. The Specific Technologies team will be available during the conference at booth #13B.
About the SpecID System
During growth in culture, bacteria produce small molecule volatile metabolites unique to their species and in some cases to their strain. Utilizing an inexpensive printed chemical sensor array to obtain a fingerprint that combines detection and identification into a simple, automated 2
single step, the novel SpecID system identifies microorganisms from a phenotypic metabolic signature obtained during growth.
About Specific Technologies
Specific Technologies' industry-leading team has developed clinically proven, regulated in vitro diagnostic systems based upon a unique, low cost and labor-saving metabolic signature technology that enables rapid detection, Gram status and identification (ID) of microorganisms directly in the blood culture bottle. The Company's patented chemical fingerprint allows ID to be determined in a single, hands-free step, enabling faster time-to-result, laboratory costs savings and labor saving that speed time from sample-to-answer. Leveraging the same innovative technology, Specific is also developing an antibiotic susceptibility testing (AST) paradigm that would represent a new level of speed, ease of use and affordability in the all-important phenotypic determination of antibiotic susceptibility. These two systems work in concert to offer a modernized next-generation work flow for the microbiology laboratory. Specific Technologies is located in Mountain View, CA.
Corporate Contact:
Email: firstname.lastname@example.com
The Specific Technologies logo, Specific Technologies, and SpecID are registered trademarks or trademarks of Specific Technologies, Inc. in various jurisdictions.
1 Liu, V. et al. "Hospital Deaths in Patients with Sepsis from 2 Independent Cohorts." J. Am.
Med. Assoc. 2014, 312, 90.


text: Batteries included is a bad idea when the community is this divided. Relative no-brainer topics in other communities like how text should be represented are highly contentious. I'd sooner see some basic test cases hammered out and integrated into base before a real attempt at this is launched. Something that would help the Cabal devs. On Tue, Sep 27, 2016 at 6:14 PM, Joachim Durchholz <jo at durchholz.org> wrote: > Am 27.09.2016 um 23:25 schrieb Olaf Klinke: >> >> Can someone please define what exactly a "batteries included" >> standard library is? > > > Anything you'll typically need is already available. > For some value of "typically need", so it's slightly squishy - here's a list > of batteries I'd like included: > - Reading/writing files > - Reading over HTTP (reliably - HTTP is surprisingly complex) > - Search&replace in test streams > - Easy-to-use string->string maps > - JSON parsing and printing (bonus points for YAML) > - GUI stuff > - Website stuff > - Sending mails > - Solid ecosystem: > - build system, > - library directory, > - no-brainer automated testing support. > (Complicated testing means more bugs in test code than in > production code - this diverges.) > >> IMHO that Python-Haskell comparison is unfair. >> >> Although both claim to be general-purpose languages, the focus in >> Haskell certainly has been on language research for most of its life. > > > I do not think that Python actually comes with all batteries included. > And in some areas support is pretty bad. > >> I recently hacked together a web client in python, my first project >> in that language. Documentation is excellent. Yet I am still >> horrified I had to use a language that provides so few static >> guarantees to control megawatt machines. > > > That, and the idea that class and function declarations are executable > statements. > Circular dependencies are "handled" by passing partially-initialized objects > around; the Python interpreter handles this with no problems, but > programmers have fun because nobody assumes incomplete initialization. > > I.e. Python's language semantics is broken by design in pretty fundamental > areas. > > That said, it's good for banging something together quickly. Been there, > done that, got the t-shirt. > Just don't do anything that you need a team for with it, the lack of > guarantees will really start to hurt. > >> What puts me off Haskell nowadays is the direct result of Haskell's >> roots in language research: Often when I come across a package that >> does what I need, it uses the conduit, lens or another idiom, which >> are like a language in a language to learn. In milder ways Python >> seems to suffer the same problem. > > > I think Python shares that problem with Lisp: it's so easy to add another > meta-idiom that too many people actually do this, and most don't even think > about composability or guarantees. > >> So please, developers: Write more >> >> batteries, but make them expose a neat lambda calculus interface if >> possible that can be combined freely with other batteries. > > > I sense a conflict of objectives here. > Having many batteries pushes you towards wide APIs. > However, the wider an API, the harder it is to make it combinable. More > surface that must be made to match. > > Making an API that's feature-complete *and* narrow is really hard and takes > a huge amount of designer and programmer time, plus the willingness to lose > most of your existing user base for an unproven idea of improvement. This > road is a really hard one, and you need corporate backing or personal > obsession to follow it. > > _______________________________________________ > Haskell-Cafe mailing list > To (un)subscribe, modify options or view archives go to: > http://mail.haskell.org/cgi-bin/mailman/listinfo/haskell-cafe > Only members subscribed via the mailman list are allowed to post. -- Chris Allen Currently working on http://haskellbook.com


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5 long-term projects to attempt in Football Manager 2020
From making Salzburg a powerhouse to completing the game with Woking, these Football Manager challenges should keep you busy while social distancing.
Club: Leeds United
Objective: Earn promotion and win the Premier League.
Transfer budget: £1.2m
How to do it: After Marcelo Bielsa's mysterious departure, it's up to you to get Leeds back to where they belong.
To do so, you'll have the club's best squad in years at your disposal.
While Kalvin Phillips and Pablo Hernandez are the star names, you have solid Championship players in every position, including central defenders Liam Cooper and Ben White.
The Under-23 squad is also packed with youngsters who are almost ready to step into the first team. Sixteen-year-old Nohan Kenneh is a special talent who, with time, can develop into one of the best holding midfielders in the game.
It's no surprise Leeds are among the promotion favourites, and reaching the Premier League in the first season should be a given.
That's not enough for this ambitious club, though. The board's five-year plan expects you to have achieved a top-half finish by the end of the 2023/24 season.
But why stop there? The supporters remember the days of Don Revie, and you can join him and other Leeds greats by competing for – and winning – the title.
Leeds' standing in the game means you should soon be able to attract the kind of quality players to help you do just that.
With a 37,799-seater stadium that the board plans to expand, superb training facilities and a great academy, this club is set up for success.
Now it's just your job to achieve it.
Key players: Kalvin Phillips is possibly the best player in the Championship and will be a star player even after promotion.
Pablo Hernandez and Helder Costa provide quality on either flank.
Club: RB Salzburg
Objectives: Win the Austrian league five times in a row and the Champions League once.
Transfer budget: £17.2m
How to do it: Salzburg have developed a reputation for snapping up young gems from all over the world, developing them, and selling them on at a huge profit, and you should persist with that approach to take them to the next level.
Things might be a bit sticky at first after some generous release clauses resulted in the January sales of Marin Pongracic, Takumi Minamino and the main man Erling Haaland (in real life).
You should still romp to the league title, which is bound to result in interest in more of your players. While you shouldn't be afraid to knock back low offers, you also shouldn't be afraid to accept good ones.
Receiving £100m or so from two or three player sales after your first season can fund the signings of several of the next generation. The South American market is fertile, and produces players who are generally cheaper and as good as the ones you've sold – although watch out for the Austrian Bundesliga registration restrictions (seven non-EU players per squad).
By sticking to this model you will quickly build a team capable of competing with the best teams in Europe. With your finances in such a healthy state, you can occasionally splash out on a bigger signing when required, too.
On the field, adopt a high-pressing, attacking style. The board and fans crave an entertaining winning machine, and you have the tools to provide one.
Key players: Jerome Onguene and Maximilian Wober should provide you with a solid base at the back, and are both sellable assets.
Trust Dominik Szoboszlai to run your midfield, even if he is more potential than the finished product to begin with.
Club: Bolton Wanderers
Objectives: Escape relegation and earn £10m from player sales over three years.
Transfer budget: £0
How to do it: When you start with a club who don't even begin the season in their natural position in the alphabetical order, you know you're facing an uphill task.
But with Bolton, a 12-point deficit is only the first of your many problems.
For a club in crisis, the squad isn't hopeless. Kean Bryan, Jason Lowe and Daryl Murphy provide a solid spine, while Dennis Politic has plenty of potential in the attacking midfield positions.
But any hope of improving the team around those four is dashed when the board provide you with a transfer budget of £0 and an available wage budget of less than £3k p/w.
Morale is extremely low. Only a handful of your players are happier than 'Okay', while several are miserable.
So why bother? Well, this job provides you with the chance to really prove your managerial mettle.
Murphy is the star man, so your best bet is probably to build your attack around him. With a heading rating of 16, a direct style could suit both him and pacey strike partner Joe Dodoo.
You can then concentrate on keeping them out at the other end.
Once safety is assured, you are going to have to help get the club back on track financially after years of disastrous mismanagement.
Ali Crawford, Remi Matthews and Politic are among several young players with heaps of potential. Selling them for seven-figure fees can enable you to start moving back up the leagues and become a Bolton legend.
Key players: Kean Bryan will be crucial at centre-back, with Ryan Lowe patrolling the defence.
Daryl Murphy will probably have to score a large proportion of your goals.
Club: Inter Miami
Objectives: Win the MLS Cup and become the USA's most reputable club.
Transfer budget: £15.5m
How to do it: The first challenge you'll face as manager of Inter Miami is getting through a six-month holiday until mid-December 2019, when the MLS season is about to start.
As one of the league's two new expansion teams, you're tasked with reaching the playoffs in the franchise's first ever season.
And if that wasn't pressure enough, you'll have to do it with one of the most famous footballers of all time breathing down your neck.
David Beckham and the rest of the Inter Miami board have plenty of ambition. They expect silverware by the end of 2024, and you won't get away with missing the playoffs even once during that five-year period.
Beckham has said "Miami needs a star", and that's reflected in the board's insistence that you target high-reputation targets in the transfer market.
The £15.5m transfer budget should help you bring the next Steven Gerrard, Andrea Pirlo or Robbie Keane to the MLS.
This squad isn't far from contention, though, and almost all of the club's key players are under the age of 27, so not much work is needed.
There's plenty of opportunity to bring in new players on the cheap, too.
Along with your hefty budget, you can trade with other MLS sides and use the expansion draft – which takes place on 17 December – to pick up players from other clubs in the division.
Key players: Rodolfo Pizarro, Wil Trapp and Nicolas Figal should form the spine of your team for years, as they're all aged between 25 and 26.
Club: Woking
Objective: Win the Champions League in six seasons
Transfer budget: £0
How to do it: Jay from The Inbetweeners famously claimed to have completed Football Manager by taking Woking from the National League to the Champions League in six seasons.
Why not do the same?
It won't be an easy task. Woking aren't just a National League club, they're a National League club in real danger of relegation.
Predicted to finish 19th, you need to immediately work wonders as failing to earn promotion in the first season would make it incredibly hard to stick to Jay's ridiculously tight schedule.
It's not all bad, though. Former England international Matt Jarvis is in the squad, while Martin Tyler – yes, that Martin Tyler – is a member of your backroom staff.
You'll have some freedom in how you get the job done, as the only philosophy imposed by the board is to sign players under the age of 23 for the first team.
Relying on young players will be necessary anyway, given the transfer budget is non-existent.
By finding an affiliate club from which you can poach loanees and making some crafty free-agent signings, you can make quick progress through the lower divisions. Once you reach the Championship, things should get easier.
Succeed, and who knows? Maybe you'll be offered a role in the England setup.
Key players: Matt Jarvis is by far the biggest name at the club and is an exceptional left midfielder, while Jake Gray has the potential to be just as good on the right.
Dave Tarpey has a finishing rating of 13, making him a great option in attack.
Visit Betway's football betting page.


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The Basics
Hearing aids come in two basic styles: those that fit in the ear and those that sit behind the ear.
- In-the-ear hearing aids require impressions of your ears for a customized fit and have the electronics built into the custom made shell. They range in size from the tiny completely-in-the-canal (CIC) which sits deeply in your ear canal, to the larger standard ITE which a full-shell that fills the entire bowl of the ear.
- Behind-the-ear (BTE) aids have the electronics built into a small case that fits behind your ear and sends the sound to your ear canal by a tube or wire. Because the case doesn't have to fit inside your ear canal, BTE's generally have more features than ITE's and are easier to adjust.
- A third style of hearing instruments, called a Remote Microphone (RM) hearing aid, is sometimes referred to as "the best of both worlds". The RM design is unique because the microphone is placed at the end of a flexible tube, which is then tucked securely in the outer portion of the ear. The rest of the instrument is inserted into the ear like a conventional CIC design. By combining the benefits of the behind-the-ear (BTE) and in-the-ear (ITE) styles, the RM offers a comfortable fit, is virtually invisible and offers maximum noise suppression.
Today's hearing aids come in a variety of sizes, styles and colors so you can choose one that best fits your hearing needs and you feel confident wearing.
Other Factors to Consider
- Anatomy – the shape and size of the outer ear and ear canal may determine which type of hearing instrument you can wear.
- Your manual dexterity – some styles are easier to handle, insert and clean than others.
- Type and degree of hearing loss – individual variations in hearing loss can pose unique challenges and require different types of amplification.
- Your lifestyle – it's important to consider your favorite activities and the environment you spend most of your time in.
Most Current - ReSound LiNX 3D
The future of Smart Hearing is here. With ReSound LiNX 3D you will be able to do more and be more than you ever thought possible. Because it's up to 50% better at identifying speech in various environments, you can hear up to 80% more of the sounds around you and understand up to 40% more speech in noise all while enjoying best-in-class streaming and control.
With ReSound LiNX 3D, you can better connect to the world around you with excellent sound quality and clear speech understanding, all in a comfortable, discreet hearing aid.


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Design Systems Newsletter
Lots of new components for you to enjoy:
Some upcoming gems are hanging out in the Lab:
In early July we made a change to the CSS helper classes provided by the Component Library. This change replaced the Bootstrap-era naming scheme based on 5px increments with our new 4px grid that we express in terms of "spacing units". The value of the units are also now expressed as REM units.
This change will allow designers and engineers to speak a common language and more easily implement UI based on our new design guidelines.
We round down, so 15 pixels became 12 pixels, which we now refer to as
3x—or three times our spacing unit of 4 pixels (3×4 = 12). This then gets translated to REM (12 / 10 = 1.2rem).

↓ becomes ↓

This spring, we sent out a survey to Product Designers hoping to learn how the team starts new projects in Figma. We took the common themes from the survey and follow-up conversations and created a new Figma template to make starting a new project easier and more predictable.
We know searching for files and filling in text fields in Figma can be tedious, so we've also created a Figma plugin that enables you to quickly generate a starter template. To get started, create a new Figma file, right-click and run the "Gusto Starter Template" plugin.
This summer, Design Systems welcomed two new interns: Kayla Buki (engineering) and Celine Fucci (design). They have been working diligently on a replacement Tabs component—from research, to design, to engineering. Their project is now available in the Lab and will soon be available in Workbench core. We're thrilled to have had them on our team and thank them for bringing this much-need component to Workbench.
This spring, Design Systems participated in a project to overhaul the primary navigation in Gusto. A beta was released in May to concierge customers and has now been made available to all users. Users can currently opt in/out of the beta with a toggle switch.
Usage statistics are being monitored to learn how the new nav is being used, but the Information Architecture team will likely flip the switch and make it the official nav in the next month or two. This change will also make permanent some page-level changes that make common tasks easier (such as changing the account password).
Earlier this year we launched our new documentation site to serve as the canonical source for understanding and using our design system. We've been adding content and are starting to catch up with documenting some of Workbench's first components.
- The documentation site was moved to its own repo, which has simplified development (who would have thought that maintaining three build systems in one repo would be problematic?!).
- New "Usage" tab: some of the newer component documentation pages have a Usage tab with context to understand the intended purpose of the component. Not all components will need this level of detail, but some do.
- We're making a push to get all the form components documented in the near future and will reach parity with other components shortly thereafter.
This documentation is meant to be a self-service resource to answer any questions you have about how to use our system. Please let us know if we're missing anything; we want it to be useful for you.
We continue to deprecate more and more components in the Component Library in favor of their Workbench equivalents. Storybook is very limited in its ability to call this out in the UI, but we've done what we can to call them out and link to docs about its replacement.
- StepTracker
- PercentageBar
Design Systems is hiring both designers and engineers, including an engineering PE! Know someone who might be interested? Send them our way!
Warmest regards,Team DS • Ben, Brad, Daniel, Eric, Jordan, Josh, Juliann & Lise


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Plant Manager - 20 Years of Experience - Near 95350
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Twenty years of Progressive responsibility in managing global operations, improving business performance, reducing cost and increasing customer loyalty.
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Manufacturing VP - 20 Years of Experience
High impact manufacturing leader with 25+ years success driving growth and profit improvement through lean manufacturing concepts and business process standardization for fast-paced manufacturing companies serving B2B and B2C markets. After completing 3 Plant General Manager positions with General Motors Corporation ,achieved "game changing results" for 4 companies in 3 industries . Building teams . that deliver "world-clas...
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Plant/Production Manager - 20 years manufacturing production experience
I am seeking the position of a Plant and/or Production Manager, where over 20 years of production managerial experience will add value to any organization right away. In every position held, whether it be owner, plant manager, or production manager, I assumed the ultimate responsibility for the plant's continuous improvement and enhancement of plant operations.
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TOPEKA – (November 5, 2021) – Kansas Attorney General Derek Schmidt today filed a federal lawsuit challenging the new federal vaccine mandate for private employers with more than 100 employees, which was promulgated today by the Occupational Safety and Health Administration. The new mandate, issued as an "emergency temporary standard," requires that employees either be vaccinated or receive frequent testing for COVID-19 and would apply to all private-sector employers with 100 or more employees, affecting thousands of Kansas workers and businesses.
Schmidt joined six other state attorneys general in filing a petition with the U.S. Court of Appeals for the 6th Circuit, following through on his previous warnings about the doubtful legality of using OSHA emergency powers to mandate employee vaccinations or testing. Today's filing asks the court to review the legality of the new mandate, arguing that OSHA lacks the statutory and constitutional authority to issue it. The attorneys general also plan to file a motion asking the court to stay the mandate pending the outcome of the case.
"Nothing in federal law gives OSHA this kind of far-reaching authority," Schmidt said. "Businesses that do not comply would be subject to steep fines. And to make matters worse, state and federal governments have just announced they will stop paying the cost of testing for businesses, shifting that cost onto businesses themselves. The net effect of this overreaching federal mandate is to discourage private businesses from employ unvaccinated workers by making it more costly, once again threatening the livelihood of many Kansas workers and businesses and promising more disruptions to supply chains nationwide."
The power to issue emergency temporary standards was delegated to OSHA by Congress for the express purpose of protecting employees from grave dangers posed by exposure to substances or physically harmful toxins encountered at work. The attorneys general argue that authority does not extend to risks that are equally prevalent at work and in society at large. They point out that as recently as last year OSHA agreed with their assessment, noting in the lawsuit that just last year "OSHA refused to issue a nationwide emergency temporary standard for COVID-19 because 'COVID-19 is a community-wide hazard that is not unique to the workplace.'"
The coalition also points out that each state "has enacted its own laws and policies — or declined to issue certain mandates — in a way that balances the need for public health with the right of its citizens." OSHA's nationwide mandate takes away that power from the states and adopts a one-size-fits-all national vaccination requirement, which is beyond the federal government's authority.
"As I have said many times, I encourage Kansans to be vaccinated, but that personal health care decision should be made by each individual and not mandated by the federal government," Schmidt said. "At a time when Kansas employers and employees are desperately seeking a return to normalcy, this mandate would further disrupt and impede their efforts in private workplaces all across Kansas."
This case is the second filed by Schmidt challenging the federal government's recent attempts to mandate vaccination. Last week, Schmidt joined six other attorneys general in filing a lawsuit asking a federal court to declare illegal a different federal vaccination mandate – one applying to businesses and universities that participate in federal contracts – and to block its implementation. That suit is pending in the U.S. District Court for the Southern District of Georgia, Augusta Division.
A copy of the lawsuit filed today is available at https://bit.ly/3o2GOTq.
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Opus Genetics announces agreement with Massachusetts Eye
RALEIGH, NC, Nov. 11, 2021 (GLOBE NEWSWIRE) – Opus Genetics, a patient-centered gene therapy company that develops treatments for inherited orphan retinal diseases, today announced an agreement to license its third preclinical program to treat mutations in the NMNAT1 gene, which cause a specific form of Leber's congenital amaurosis (ACL), from the Massachusetts Eye and Ear, the main teaching hospital of Harvard Ophthalmology.
The new program, OPGx-003, is based on the work of Eric Pierce, MD, Ph.D., director of the Ocular Genomics Institute and William F. Chatlos professor of ophthalmology at the Massachusetts Eye and Ear and the Harvard Medical School, and co-founder of Opus. OPGx-003 is a gene augmentation therapy designed to arrest functional deterioration in pediatric patients with degenerative retinal disease caused by mutations in the nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) gene. Recent preclinical data have demonstrated the potential of this gene augmentation approach to achieve stable rescue of retinal structure and function. Opus plans to file an IND for OPGx-003 in the first half of 2023.
âWe are delighted to collaborate with Dr. Pierce, who will bring his expertise in retinal gene therapy to the search for a novel treatment for retinal degeneration associated with NMNAT1,â said Ash Jayagopal, Ph.D., Scientific Director of NMNAT1 Opus Genetics. âThe addition of OPGx-003 to the Opus pipeline further underscores our commitment to bringing together the resources and expertise necessary to take promising science from the laboratory to the clinic and ultimately to the patients who need it, and strengthens the importance of our innovative patient-centric model. . "
âI saw with my own eyes the need for new treatments for rare inherited retinal diseases,â said Dr. Pierce. "As someone who has dedicated my life to researching this space, I firmly believe that Opus is an ideal company to advance this work and make a difference for patients in need."
Opus' main program, OPGx-001, is designed to process mutations in the LCA5 gene, which encodes the lebercilin protein. The company's second program, OPGx-002, will focus on restoring protein expression and stopping functional deterioration in patients with retinal dystrophy caused by mutations in the retinal dehydrogenase (RDH12) gene. (LCA13).
About Opus Genetics
Opus Genetics is a revolutionary gene therapy company for inherited retinal diseases with a unique model and purpose. Backed by the venture capital arm of the Foundation Fighting Blindness, the RD Fund, Opus combines unparalleled insight and commitment to the needs of patients with wholly owned programs in many orphan retinal diseases. Its portfolio of AAV-based gene therapy tackles some of the most neglected forms of inherited blindness while creating a new scale and efficiency of orphan manufacturing. Based in Raleigh, North Carolina, the company leverages the insights of top scientists and the expertise of pioneering ocular gene therapy to seamlessly drive transformative treatments for patients. For more information, visit www.opusgenetics.com.
Dr Pierce owns shares and is a consultant for Opus Genetics.
Media contact:
Heather anderson
[email protected]


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December - 2016 - Special issue
CXO Insights
Direct to Consumer Prowess with Digital
Srividya Kannan, Founder & Director, Avaali Solutions
Tuesday, December 20, 2016
Headquartered in Bengaluru, Avaali Solutions specializes in providing enterprise solutions for content & business driven collaboration projects.
Customer expectations and customer behavior is changing and brands are working hard to keep pace. With much of the information available at their fingertips, consumers are in control like never before. It is all about data - brands are expected to have more data about their consumers, and this data is today is the real power that is driving customer experiences and consequently revenues, market share and profits. At the same time, with these new channels, marketers are no longer required to invest heavily in the form of marketing budgets on traditional channels. Personalization is taking the lead. The more intense work that the brand does in creating and delivering personalized customer engagements, the more meaningful is their relationship with the customer while continuing to gain valuable customer data along the way.
Going direct to the consumer has always existed for quite some time, dedicated stores of the likes of Nike and Apple have always existed, however, digital has brought in benefits in terms of significantly shrinking time to customer reach as well as the associated costs. Done effectively, these channels have delivered completely new business models for enterprises across segments. In a recent report from the Reuters Institute for the Study of Journalism (RISJ), the use of mobile devices to access news on a weekly basis surged to almost half 46 percent in the previous year and the rise of sites such as Facebook, YouTube and Twitter. Traditional advertising based business models are being severely challenged with the consumer backlash against digital ads. The financial results of Facebook for the June 2016 quarter are just reflective of this trend. Going by its numbers Facebook will make more revenue in advertising than all of the U.S. newspapers put together - of a $6.4 billion of total revenue 59 percent growth, advertising revenue was 6.2 billion 63 percent growth of which mobile advertising was 84 percent. The travel industry is going digital - 60 percent of leisure and close to 45 percent of business travelers are making their arrangements via the internet.
Recommendations and social media reviews are increasingly influencing consumer decisions relating to destination, choice of hotels and others. There is significant work being done to attract and retain customers using social and mobile platforms, right from AirBnB, Hilton, Accor to Denver International Airport and Four Seasons and others, the success stories are many. Take the case of Turkish Airlines which posted a record high net profit in 2015 largely driven by profit from main operations. Right from the world's first ever 'Periscope' live broadcasted flight to creating an integrated multi-platform approach that communicates that they fly to most destinations in the world, Turkish Airlines has been investing in several initiatives to reinforce the brand. The pharma industry is moving to a solutions and outcome based industry working with an ecosystem of players to offer combo solutions that leverages the strength of each partner for what it does best. Companies like L'Oreal and Nike are investing in portal e-Commerce experiences that allow the consumer to continue the transaction across channels from where they left. Insurers like Aetna, MetLife and Aflac have been investing in creating personalized digital experiences to provide unprecedented levels of customer satisfaction, brand engagement and trust. The retail business model with digital is now a long told story.
Digital business is not only shaping new revenue models for enterprises but also helping them engage with customers during the sale, post sales in the form of taking feedback, reviews as well as ongoing customer support. There are predictions that sales professionals will be eventually replaced by robots. In fact some industries have already started doing it. The Forrester 2015 findings for pharma suggests in their report titled 'Its Death of a (B2B) Salesman' suggests that reps involved in basic 'order processing' for commodity products are most vulnerable, while sales professionals that promote more complex products will continue to add value to customer interaction. As bots take over, they will soon become the face of a brand. They not only help consumers find the right product but also provide recommendations and tips based on customer history and user profiles, allowing a great opportunity for brand to up-sell and cross-sell. Take Domino's experimentation of tweeting the pizza emojis to take orders. Tailoring a service for each consumer has experienced several innovations using bots. It not only takes orders but could potentially also address customer complaints if the pizza delivery is late. A whole new market with bot builder platforms is now coming up allowing making it simple to create a customer satisfaction or a sales bot.
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There is no particular work i've made that I feel I shouldn't put online. However, theres this thing called cat fishing, where people take your pictures and start a whole new social media site with them. There is that fear that someone could be pretending to be you and you have no idea. People typically react to this by starting to put watermarks on their pictures and of course blasting them on social media.
So for people who are afraid of having their work stolen, I suggest putting watermarks on your work. This will show us who really supports the artwork or who just wants to steal.
My favorite quote from the DConstruct podcast states, "anytime time you put a lock on something and don't receive a key , that lock is not put there for your benefit". I agree with this quote because you shouldn't associate your work with a company that takes your ownership away whilst it is supposed to protect your work from being stolen.


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Tento článok bol vytlačený zo stránky https://referaty.centrum.sk
Weather, fauna and flora
Weather is always changing. Some climates have marked changes of weather type during the year. For example, a monsoonal place has warm, cloudy, wet weather in summer and cooler, sunnier, dry weather in winter. we can identify the following main types of climate:
-warm temperate
-cold temperate
Climates also vary over time change very gradually over decades and centuries. Human activity may be influencing this.
Flowers and plants are very sensitive to the weather. Plants are adapted to the climate they live in for the most part.
Many animals are adapted to the weather, and where they are found is tied closely to the climate and its impact on the availability of suitable food. Animals living in the coldest parts of the world, such as seals and polar bears, have thick layers of fat under their skin to protect them form the cold. Some animals hibernate during the coldest part of the year, living off stored fat and water to survive. Many animals migrate to breeding areas to escape starvation during the winter season when food is harder to find.
In hot places, animals can often store water in their bodies such as camels, or are adapted to live no only tiny amounts of moisture. Many come out only at night to hunt and feed.
Koniec vytlačenej stránky z https://referaty.centrum.sk


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Israeli Coronavirus Czar Prof. Roni Gamzu met Tuesday with Sephardic Chief Rabbi Yitzhak Yosef to consult with him on halakhic issues related to the fight against the coronavirus.
After the meeting, the Chief Rabbi and Prof. Gamzu issued a joint statement in which they implored the public to obey the instructions of the Health Ministry and other relevant authorities.
At the beginning of their joint statement, they highlight the health dangers and the need to tighten the guidelines for "dealing with the corona epidemic that has claimed many victims, young and old, healthy and sick."
"Our Torah is the Torah of life, and commands us very strongly to protect our lives, and the Torah also said, and to live by it, and as the sages extrapolated in Tractate Yoma 85:B: and not to die by it," the statement continued.
Rabbi Yosef quoted Maimonides, who wrote: "And it is forbidden to procrastinate in desecrating the Sabbath for a patient who is in danger, as it is said: And a man will do them and live by them, and not that he will die by them." Rabbi Yosef also cited the Tosafists in Tractate Baba Kama, who wrote that a person should be even more careful in not causing harm to others than he would be for himself.
Rabbi Yosef and Prof. Gamzu both declared that it is an obligation to wear a mask in public spaces and inside synagogues, as well as to maintain social distancing and to avoid large crowds.
Regarding people who experience symptoms such as difficulty breathing, fever, cough or the loss of smell and taste, the two stated that "it is an absolute obligation for them to be tested and it is strictly forbidden for a person to judge his own condition and endanger others."
"As I have already written in regards to the Health Ministry guidelines, according to the halakha, whoever puts others in danger, it is possible that someone will be murdered by his hand, and he will bear his guilt," Rabbi Yosef said.


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Zachary Levi Wants Shazam! Fury of the Gods to Come Out Sooner Than Next Year
Shazam! star Zachary Levi would love for Fury of the Gods to come out faster than its 2023 release date. The actor sat down with Collide to preview the film. Of course, he ended up sharing some excitement about the wild scale of the sequel. But, a lot of fans are bummed that Shazam isn't getting its sequel until 2023. Warner Bros. has a massive cinematic slate set up for the next 3 years or so. But, before the magical hero can get another appearance at the plate, The Batman and The Flash will get their turns in the spotlight. Everyone wants their movie to be the next one up, but that just isn't realistic. For Levi, he's willing to wait with The Rock and Black Adam for another visit to that universe. (Even if the star wishes they could speed some things up.)
"I will say that I genuinely — and this is not just lip service — I'm really proud of the first one, I think we made a really, really good movie. I think the second one is better. I think that we had more time, we had more budget. We had, essentially, the entire cast returning, and we all knew our characters a little bit more; we could kind of sit into them a little bit more. Henry Gayden, who wrote the first script, wrote the second, and he did a fantastic job doing so."
"Everything just clicked even a little bit more and a little bit more. And also the kids have grown up a little bit more, so even the sensibilities of them become even slightly more mature which brings it closer to my or other people's adult minds, so there's even more connection there, I think. The action's great, the comedy's great, the relationships are great. The bad guys, Helen Mirren and Lucy Liu, are fantastic. I'm very proud of it. I want it to come out sooner than June of 2023."
In some further comments, Levi explained how they're patiently waiting their turn in the release schedule.
"Fortunately, we are amongst a huge group of very cool characters and actors that play those characters. They're already more established in a lot of ways because of the DC movies that preexisted before we came in. So we're a little bit of a JV coming into the varsity squad, and there's a lot of titles that need to come out to the world," he mused. "I get it; studios have to make a concerted effort about not cannibalizing your own titles. You can't release them too close to each other, otherwise you might cannibalize each other. Plus, you have to take into consideration all the other studios' releases and all that stuff. So that's where it is — but, you never know, maybe it'll come out sooner. Here's hoping and praying, I hope."
Would you love to see Shazam! 2 in 2022 instead? Let us know down in the comments below!
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"I first went to see Michele begrudgingly to appease my wife who thought it would help me with work-related stress. That was well over 3 years ago and as usual, my wife knew best.
Through a combination of coaching, meditation and movement Michele has helped me to better understand and take care of myself. I look forward to my sessions every week and know that this time is an essential part of my wellbeing both mentally and physically."