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The use of pharmacologic ascorbate in the treatment of hepatocellular carcinoma: mechanism of cytotoxicity and synergism with the multikinase inhibitor sorafenib
Pharmacologic ascorbate's use as an adjuvant chemotherapeutic in advanced cancer has a controversial history. In the past decade, interest in this treatment was renewed based on a re-assessment of the pharmacokinetics of ascorbate, which led to the discovery that ascorbate's selective cytotoxicity only occurs at plasma levels achievable through intravenous administration, but not through oral administration. Hepatocellular carcinoma (HCC) is the 2nd leading cause of cancer deaths worldwide. It is often diagnosed at a late stage when few treatment options remain. The current standard of care for unresectable HCC is sorafenib, a multikinase inhibitor targeting Raf-1 and VEGFR-2 and -3, as well as other kinases. New combination therapies are urgently needed. Here we investigated the mechanism of selective ascorbate-induced cytotoxicity in tumor cells, including Hep G2 cells, compared to primary hepatocytes. Additionally, we examined the combination of ascorbate and sorafenib in Hep G2 cells and performed a preliminary assessment of this combination in Huh-7 and SNU-449 cells. H2O2 formation was required for ascorbate cytotoxicity, as extracellular catalase treatment protected tumor cells. H2O 2 generated by glucose oxidase treatment also caused cell killing, but treatment with a pharmacological dose (5-20 mM) of ascorbate was significantly more cytotoxic at comparable rates of H2O2 production, suggesting that ascorbate enhanced H2O2 cytotoxicity. Ascorbate treatment of Hep G2 cells caused deregulation of cellular calcium homeostasis, resulting in massive mitochondrial calcium accumulation. Ascorbate acted synergistically with the chemotherapeutic sorafenib in killing Hep G2 cells, but not primary hepatocytes, suggesting adjuvant ascorbate treatment can broaden sorafenib's therapeutic range. Sorafenib caused mitochondrial depolarization and prevented mitochondrial calcium sequestration. This observation prompted us to performed preliminary experiments using extracellular flux analysis (Seahorse Bioscience) to investigate sorafenib's effects on the mitochondrial electron transport chain and mitochondrial energy conservation. Here we provide evidence that sorafenib may be a reversible general inhibitor of the ETC. Preliminary results of the combination of ascorbate and sorafenib in Huh-7 and SNU-449 cells varied in effectiveness compared to the synergistic response seen in Hep G2 cells, suggesting the net effects of sorafenib result from multiple actions of the drug on different cellular functions, the outcome of which may vary depending on the specific properties of these cells. Additionally, we present the case of a patient with hepatocellular carcinoma (HCC) who had prolonged regression of a rib metastasis upon combination treatment with ascorbate and sorafenib, indicating that these studies have direct clinical relevance.
Subject Area
Molecular biology|Pharmacology|Biochemistry|Oncology
Recommended Citation
Rouleau, Lauren L, "The use of pharmacologic ascorbate in the treatment of hepatocellular carcinoma: mechanism of cytotoxicity and synergism with the multikinase inhibitor sorafenib" (2016). ETD Collection for Thomas Jefferson University. AAI10190418.


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Funny picture book
Susan Batori – Platz da, ihr Hirsche!
So many funny characters & scenes to enjoy in 'Platz da, ihr Hirsche!', a new picture book about tolerance and sharing illustrated by Susan Batori for Penguin Junior Verlag.
Susan Batori – Bug on a Rug
Pug is snug on his rug. But what happens when along comes BUG?! With a claim to the rug?! The two engage in a hysterical, rhyming battle of wits and strength until Slug asks the necessary questions and helps them find common ground.
With hilarious artwork by Susan Batori, 'Bug on a Rug' hits shelves this April from Sleeping Bear Press.
Susan Batori – Don't Call Me Fuzzybutt!
Bear is a very light sleeper, so when Woodpecker wakes him he becomes quite grumpy!
The two engage in a feisty exchange of name-calling and gossip with the rest of their forest neighbors. Can they patch it up before Bear loses too much sleep?
'Don't Call Me Fuzzybutt!' is a brilliantly funny picture book illustrated by Susan Batori which will spark meaningful conversation about conflict resolution, gossip, and the hurt caused by name-calling.
Sam Caldwell – Sneaky Shadows
'Sneaky Shadows' hilariously illustrated by Sam Caldwell will have kids in fits of giggles as they try and guess what the shadows really are!
Packed full of cheeky, laugh-out-loud fun, this playful new picture book from Berbay Publishing is available now.
Nicola Slater – The Leaf Thief
Hitting the shelves this month is 'The Leaf Thief', a brilliantly funny story of the seasons featuring a super-sassy squirrel illustrated by Nicola Slater for Scholastic.
Anja Boretzki – Perfectly Peculiar Pets
Perfectly Peculiar Pets is out now! Filled with fun rhymes, quirky black-and-white illustrations and exotic animals, this hilarious collection of poems illustrated by Anja Boretzki is perfect for reading aloud.
Susan Batori – Shampooch
Introducing Shampooch, the most pampered dog in the park! Dog lovers are in for a treat this January as Maverick are set to release this hilarious new picture book illustrated by Susan Batori.

subset: commoncrawl


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The health minister also explained that the scale recruitment of overseas nurses that took place in last 5 years at such large scale was only a short-term measure. The most difficult part of any managers job is people management. You can also choose your private dentist and just have to pay for NHS dental treatment depending on your circumstances. If you are NHS patient with dental treatment offered by the hospital dentist. 5. You just need to fill HC1 form named as "Claim for Help with Health Costs". The general secretary of the Royal College of Nursing highlights that the "international nurses have always been there for the UK in times of need and suggested that it is not fair for them to pay for the deficits' crisis. Employees are involved as partners in the business. Your employees are the biggest asset you have. Instead of dealing with employees that develop defence mechanisms to mask their dissatisfaction with their work situation, lets look as some ways to encourage effective behaviour at work.
The market remains pretty fragmented and our growth will come from organic growth, acquisitional growth and original site contract opportunities. So there is a big opportunity for Sonic in the hospital lab market in the US and those, should they eventuate, will be contract type growth opportunities rather than straight acquisitions. Moving on to Germany. Revenue growth in Germany was strong at 7% with 6% organic growth. This is well above our best estimates of the market growth rates. If we http://www.koralbellevue.com/consultantinterviewprep/2016/09/29/ideas-on-finding-necessary-criteria-of-interview-for-national-health-service/ look at some operating highlights, we are gaining market share in all segments of our business. You can split the market into different components, GP, specialist, hospital and even into sub-specialties. I have to say that it is a great pleasure to this, because we have an outstanding business in Germany with outstanding services and quality. That is driving our reputation and, of course, driving market share gains at organic level. We're lucky to have Evangelos Kotsopoulos here, a colleague of ours, sitting in the audience. He's the CEO of our German division and it's a congratulations to Evangelos.
For the original version including any supplementary images or video, visit http://finance.yahoo.com/news/edited-transcript-shl-ax-earnings-055000236.html
The types of clear brine fluids, besides being a derivative of bromine are calcium bromide, zinc bromide, and sodium bromide fluids. These fluids are extensively used in the oil & gas well-drilling industry for http://consultantinterview.jcchristiancounseling.com/2016/09/22/picking-out-useful-secrets-for-selection-for-registrar/ high-density, solids-free completion, packer, and workover fluids to reduce the likelihood of damage to the well bore and productive zone. Brine fluids have a high density, thus prevent migration find out this here of fluids between underground formations through the well bore. The consumption of brine fluids is expected to grow in regions that are witnessing an increased oil- & gas-drilling activity. Some important regions witnessing an increase in demand for drilling fluids are Gulf of Mexico, offshore (U.S.), shale gas wells in the U.S. as well as oil and wells in Alberta and Canada. The Orinoco belt in Venezuela and offshore wells in Brazil are important markets for brine fluids in South America. Asia-Pacific, the largest market for bromine Asia-Pacific is the most favorable market for chemicals, power, and fuels and is anticipated to be the same in the coming future. The continuous rise in the production of bromine for the electronics, automobiles, and agricultural industries within the region, and for exports drives a huge demand for the bromine in terms of derivative as well as application.
For the original version including any supplementary images or video, visit http://www.prnewswire.com/news-releases/bromine-market-by-derivative-application-and-by-region---global-forecast-to-2021-300315713.html
That is to say, British-born Cypriots may apply for a Cyprus citizenship and keep their UK citizenship as well. Without the proper language, an applicant can honestly answer that he or she has not been convicted of a felony even though there may be serious misdemeanour convictions an employer needs to know about. Getting the money to go to your target college involves good grades and hard work. The cover letter is a method of expression, above all else. This will largely depend on your marital status as well as your planning prior to entering a nursing home. States have different laws pertaining to Medicaid eligibility. There are certain rules and regulations that make you eligible for US tin number. CySEC must be satisfied that the company has internal procedures in order to avoid a potential conflict of interest with its clients. If you are returning to school after some time off, particularly if you have a family, you will probably choose a school based on cost, proximity to your home, and whether they offer at least on-line classes or not. And now you know youve got it right.


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NOTICE:Opening hours and services may be different from those displayed here. Before visiting, we advise that you check ahead by phone or via social media to avoid disappointment.
If you see any details here that need updating, please let us know by submitting updates on the pub.
Horse & Groom
12A Main Street
Opening Times
|Noon - 11.00 pm
|Noon - 11.00 pm
|Noon - 11.00 pm
|Noon - 11.00 pm
|Noon - 11.00 pm
|Noon - 11.00 pm
|Noon - 11.00 pm
Meal Times
Mon - Sat noon - 8pm
Sun noon - 6pm
About the Pub
Historic Interest
The Horse & Groom was registered as an Asset of Community Value on the 8th January 2016 by Gedling Borough Council, after being nominated by the Nottingham Branch of CAMRA. It brewed its own beer on site until 1921 (Ottewell 1990). The Horse & Groom is in Gedling Borough Council's Linby Conservation Area. In the 1823 Alehouse Recognizances for the Broxtowe Hundred, the Horse & Groom was under victualler Elizabeth Merrill (County Archives C/QD/LV/4/3/79). In 1855, the Horse & Groom was fully licensed under J. Sneath and in 1876 the publican was Jacob Jennison (Post Office Directory). The Horse & Groom forms a local name cluster with the Horse & Groom pubs at nearby Moorgreen and Basford. The Horse & Groom has an historic interior rated by CAMRA as being of Regional Importance. The structure of the building is old, possibly 17th C. witnessed by the thick stone walls. Major rebuilding was carried out by Home Brewery in the 1920s and 1937. This included raising the height of the building, as can be seen on the west gable wall. Superb unspoilt village pub, with its multi-roomed layout of 1937 intact and it retains a lot of 1930s features. The central front entrance to lobby leads to small rooms to the left and right. The smoke room on the right retains its 1930s panelling to picture-frame height and the fireplace has a 1930s wood surround but a 1960s stone interior. A door from the right hand side lobby was blocked up in the 1960s and new fixed seating installed. The bar counter could be from the 1960s but the bar back looks modern. The left door leads to a parquet floored passage with 1930s panelled walls. A rare part-glazed partition wall separates the passage from a small snug, which retains its 1930s counter and stone & brick fireplace. The walls are covered with more 1930s panelling and the bar back is a mixture of old and new work. The small left hand lounge has been subject to much refurbishment (new dado panelling and fireplace) with only the parquet floor remaining from the 30s. The bar counter could be 60s work with its copper top and the bar back has a mixture of old and new work. A parquet-floored passageway leads from the rear door of the lounge to the original external door. The former off-sales was situated here with service from a hatch in the main bar area. A 'lean-to' and toilets at the rear were added in 1970 and enables you to walk all around the pub; the original outside toilets are now a coal shed. The larger bar-lounge rear-right was added in 1937 and has a large inglenook brick fireplace with a decorative ceramic strip at mantelshelf level and original slotted benches. The bar counter here looks like the original 30s one but the bar back is a mixture of old and new work. The rear single-storey Paddock Room, originally part of the stable block, was converted in the late 60s early 70s to become a cocktail bar and is now a popular dining/function room that can hold 50 people. Also, in the first part of the 20th century the pub brewed its own beer from the old stable block. (www.heritagepub.org.uk) [Gedling Borough Council; Newstead Abbey Ward / Linby Parish Council / Nottinghamshire County Council; Newstead Division / Sherwood Parliamentary Constituency]
Regular ales
This pub serves 3 regular beers.
- Lincoln Green --varies--
- Theakston Dockside
- Theakston XB
Changing ales
This pub serves 3 changing beers.
- Real Ale Available
- LocAle Accredited
- Quiet Pub
Historic Pub Interior
Interior of Some Regional Importance
- Lunchtime Meals
- Evening Meals
- Garden
- Parking
- Dog Friendly
- Family Friendly
Function Room
Linby Tea Room.
Traditional Pub Games
Quiz night Thurs.
- Real Fire
- Separate Bar
- Smoking Area
- Wifi
View on Larger Map
Horse & Groom
12A Main Street
Sat Nav Reference
- Close to Bus Routes
Nearby Bus Routes (20m)
Submit Pub Updates to CAMRA
We welcome the help of all users to contribute to this important campaigning project. Please use the form below to submit feedback or updates directly to the CAMRA branch for consideration.
Please note that any changes mentioned WILL NOT have an immediate effect on whatpub.com but will instead be emailed directly to the CAMRA branch Pubs Officer for consideration. If you provide your name and/or email address this information will also be visible to the Pubs Officer, who may use this information to follow up your feedback. IF YOU WISH TO CONTACT THE PUB DIRECT, PLEASE DO NOT USE THIS FORM.
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Approaching the one-year mark of his first term, Governor Ned Lamont's flaccid negotiating skills can't even get Democrats on board with the bigger-ticket proposals.
Two-time mayoral candidate Jeff Kohut writes in a commentary "as long as the state's resources are marshaled mainly for the sake of supporting the Stamford Area (Gold Coast) economy and lifestyle, the more inevitable the economic death of the state as a whole."
Editor Hugh Bailey and the Connecticut Post have definitely spotted something amiss with the latest transportation infrastructure plan floated publicly by the Lamont Administration.
The Governor's Office has shrewdly played its transportation plan handoff of the predictable "How is this going to be paid for?!" (inevitable) controversy. This has provided "cover" for "the plan" and allowed its actual contents and implementation ramifications to become quite secondary in consideration by legislators, the media, and the public. Indeed because of the Governor's displayed (albeit "affected") affinity for the use of the toll bogeyman as a source of money to pay for "the plan," most of the media have devoted most of their coverage of the Governor, and "the plan" to the aforementioned bogeyman, thus allowing the actual plan contents to remain a hazy, secondary consideration.
But, to their credit, Hugh Bailey and the Editorial Board of the Post have shown quite a bit more sophistication in their consideration of "the plan" than most other journalistic entities. They actually took a hard look at the "the plan" and what its implementation would mean for the state over the short- and long-term.
Editor Bailey refers to his editorial of 11/17/19, regarding this latest Lamont transportation "plan," CT2030, as "A retrograde plan for the state's future." But, as just a cursory examination of this latest, Lamont transportation "plan" will show, it has few of the hallmarks of a real plan.
And, while the Bailey editorial rightly and correctly indicts the Lamont transportation "plan" for being "retrograde"–irrespective of its unpopular inclusion of a toll-financing component–there are several glaring omissions in the Bailey/Post editorial that are of perhaps as much, if not more, consequence to the future of Connecticut than its "backwards" approach to meeting state transportation needs.
Indeed, the editorial fails to address the fact that the plan isn't a plan at all–just a prescription for temporary relief of the (main) symptom of extreme traffic congestion causing a costly dilation of commute times (to the overdeveloped Stamford Area) in Connecticut's southwest quadrant.
There is no mention of the geography and politics at the root of this mainly southwest Connecticut traffic jam, nor of its involvement in the current and predictable future economic regression of the state per the longstanding, state/federal economic development policies that support the Stamford Area economic primacy and politically engineered dominance of the Connecticut economy/Connecticut economic life–irrespective of the role of the automobile in that dominance.
Glaringly, there is no mention of the fact that the aforementioned state development policy has literally choked off and squeezed out development in most of the rest of the state, and is responsible for Connecticut's last-in-the-nation, overall economic growth (actually, continuing recession, if analyzed in isolation of Stamford Area growth).
The fact of the matter is that as long as the state's resources are marshaled mainly for the sake of supporting the Stamford Area (Gold Coast) economy and lifestyle, the more inevitable the economic death of the state as a whole. As more commuting labor, of all descriptions/pay scales, is forced to live outside of the (exclusively zoned, very expensive) Stamford Area, even as the tax bases/grand lists of the labor hosting communities continue to shrink–in a context of growing populations and increased services/infrastructure expenses, increasing property taxes, underfunded school systems, and structural unemployment–poverty and socioeconomic decay will continue to increase throughout the rest of the state, especially in the major cities. This negative socioeconomic momentum will, in a paradoxical manner, further exacerbate the population decline of the state (the latter taking the form, mainly, as the flight of professional/skilled labor and capital) from all but the southwest wedge of the state, which will ultimately find itself within a no-longer-viable State of Connecticut, and without the labor pool and state resources required to sustain a growing, albeit isolated, economic monster.
Thus, while the Post points out the regressive folly of the Lamont non-plan for Connecticut's transportation future, it doesn't use the indicated zoom lens needed to see the untenable transportation plug that has been deliberately created and sustained, (and which "the plan" seeks to accommodate)–by greed-enabled, shortsighted, state economic development policy–in the extreme southwestern portion of Connecticut at a critical transportation juncture in the state's (and region's) economic lifeline.
Any government transportation plan should be only one, enabling part of a larger, comprehensive, long-term plan of economic development (really socioeconomic development), the latter being based on a vision of high notions for the people affected by the plan. The goals of the transportation plan should stem directly from the goals of the economic development plan and should serve mainly to enable the latter.
Truly; it would behoove the Lamont Administration do a proper evaluation of the socioeconomic condition of the whole of the State of Connecticut, paying particular attention to the negative trends, such that this dying state might benefit from some visionary thinking, planning, and action before we become part of greater Rhode Island, and pass the point of no return.
In the meantime, table that transportation non-plan, with its road widening and tolls, and nurture the creation of a vision and plan for our state, with a transportation sub-plan tailored to enable the actualization of a lofty vision for an economically mighty state of healthy cities and healthy rural and suburban areas–with no one area being ceded primacy at the expense of any other(s). It wasn't so long ago that this description was the real Connecticut.


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Lily of the Valley is the birth flower for May. It signifies the return of happiness. The 9 inch tall 19 oz glass is double painted, cured and baked for durability. Please hand wash for years of enjoyment. Made in USA. Gift box is included.
We ship most items USPS Priority Mail. You will be able to track your package once it is complete at USPS.com. It will be delivered anywhere in the country in usually 2-3 days. Please take into account weekends and holidays.
Is it a gift? If you would like to send a note along with the gift, I would be happy to include a hand written note card. Just leave it in the notes at checkout.
The customer is responsible for any customs charges when shipped outside the United States.
Just contact me within: 14 days of delivery
Ship items back to me within: 30 days of delivery
Please contact me if you have any problems with your order.
I stand behind the quality of my items. A direct message or email is much appreciated if you have any concerns.
If for any reason your item is damaged when shipping, please let us know. Please provide a picture of the damaged item and I will happily send out a replacement.
If the item is a return or exchange, the customer is responsible for the shipping.
If you have any questions, please do not hesitate to contact me.
Jan 21, 2022
Great quality and beautiful!!!
May 20, 2021
Purchased as a gift for a friend. Came quickly and was well packaged. The glass was beautifully painted. The recipient loved it. In fact she used it that night.
Dec 14, 2020
Deb is great! So accommodating and sweet. My glass came out beautiful and was packed great as well. Shipping was super fast and she provided a tracking number. You won't be disappointed!


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Rome, Ga., to Host 2021-23 Tennis On Campus Southern Championship
ATLANTA - October 20, 2020 - The Greater Rome (Ga.) Convention & Visitors Bureau has been selected as the host of the 2021-2023 USTA Tennis On Campus Southern Championship, USTA Southern Manager and Tournament Director Jeff Smith announced.
The multi-day tournament brings together at least 72 club tennis teams from 35-40 colleges and universities from Alabama, Arkansas, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina and Tennessee. More than 550 players are expected to play. Typically, each team has approximately eight players who travel to the tournament, with some teams bringing as many as 10 individuals. The tournament expects to use 150-200 hotel rooms. Larger universities often bring multiple teams, with "A," "B," "C" and "D" teams.
The 63-court Rome Tennis Center at Berry College will be the tournament site. Based on the number of courts, it is one of the largest tennis facilities in the country.
The dates of the championships are set for Feb. 26-27, 2021, with Feb. 28 set aside as a rain day. The 2022 event will probably be played at approximately the same time of year.
"Tennis On Campus is perfect for those athletes who do not make the jump from high school to college varsity tennis," said Smith. "We offer dual match play, state, sectional and national championships, while helping students maintain an active and healthy lifestyle throughout their college years."
The USTA Tennis On Campus program features more than 35,000 college students competing nationwide in intramural and intercollegiate coed club play. Since its inception in 2000, Tennis On Campus has grown significantly and today is played on more than 600 college campuses across the country.
Developed by the USTA in partnership with NIRSA, World TeamTennis and the Intercollegiate Tennis Association, the Tennis On Campus program gives college students the opportunity to build leadership skills, network in a coed sports environment and compete on a college team without the rigors of playing in a varsity program. With year-round match play, and regional and national championship competition, students maintain active and healthy lifestyles through their college years. For more information visit TennisOnCampus.com.
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DIM + Curcumin 30 caps by EuroMedica
DIM + Curcumin 30 caps by EuroMedica is a supplement for estrogen metabolism and balance. It contains French Grape Seed, Curcumin, and BR-DIM in their most effective forms to work together for estrogen health.
The specifically designed formula offers relief from PMS and perimenopause symptoms. French Grape Seed VX1 provides highly absorbable oligomeric proanthocyanidins, which are polyphenols that are packed with antioxidants. These antioxidants help to improve mood and balance hormones. Curcumin is a compound of turmeric that is highly protective against oxidative damage towards cells. It can also help prevent estrogen dominance by aiding the liver in eliminating toxins that mimic estrogen. Diindolylmethane, or DIM is a plant compound. DIM can increase the "good" estrogen metabolites while reducing "bad" estrogen. Sufficient "good" estrogen levels help support the immune system, fat metabolism, and hormone balance.
EuroMedica's DIM + Curcumin 30 caps provides estrogen support that
- Balances hormones
- Promotes better mood
- Supports healthy metabolism
- Aids in weight management
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


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|BB News & Rumors Posts
|Nov 27
|[ShowBiz CheatSheet] Big Brother': Matt 'Turner' and Megan Belmonte Reveal Which Castmates Are Invited to Their Wedding - AprilSky
|Nov 26
|[ShowBiz CheatSheet] Big Brother 24': Taylor Is 'Bewildered' Her Fauxmance With Joseph Wasn't in the Show - AprilSky
|Nov 26
|[Lee Daily] Truth Behind Tyler and Angela Break Up - AprilSky
|Nov 25
|[Media Traffic] CBS's "Big Brother" 24 Star Turner Finally Takes A Shower After Finale Night - AprilSky
|More BB News & Rumors posts...
|BB Media Posts
|Nov 21
|Big Brother's Tyler Crispen Lands Lead Role In Upcoming Film [Retires From Reality TV] - AprilSky
|Nov 14
|[WWHL on Bravo] Andy Cohen asks Taylor Hale a speed round of questions about her #BB24 experience! - scoobydoo
|Nov 4
|[YouTube] THE TRUTH About Big Brother 24... With Taylor and Joseph - AprilSky
|Nov 2
|[YouTube] You Know I'm Right, Episode 203: Big Brother's Brittany Hoopes - aj401
|Nov 1
|[YouTube] BB24 Turner Vlogs Canada Trip with Joseph and Taylor - scoobydoo
|More BB Media posts...
|BB Alumni News Posts
|Nov 25
|[Screen Rant] Why The Amazing Race's Derek & Claire Are The Best Big Brother Team - AprilSky
|Nov 21
|BB Tyler Crispen ~ The Queen's Jewels - AprilSky
|Nov 19
|Just not a nice person, threatening to send his fans, lol - snakey
|Nov 17
|Portland 'Big Brother' contestant defaults on lawsuit - AprilSky
|More BB Alumni News posts...
|(TV) As always, from all of us that watch and write, to those of you that take the time to read the updates, that's a wrap for #BB24. See ya when we see ya! -NoleJP
|(TV) Taylor hugs her family. -Scott3325
|(TV) Taylor wins America's Favorite House Guest. -Scott3325
|(TV) The Big Brother 24 House Guests. -Scott3325
|(TV) Julie shows the last three votes - all for Taylor. -Scott3325
|BB Updates: Quick View (old)| Forum | RSS | Twitter Highlights
|Posts in BBCA News & Rumours(More)
|Arisa Cox Reveals Big Brother Casting Secrets
|Arisa: BB Canada renewed for Season 11.
|BBCan season finale numbers way down
|Big Brother Canada's Martin Frenet returns to reality
|Big Brother slumps in Canadian Top 30
|The Amazing Race
|The Amazing Race - Season 34, Episode 10 Discussion Thread NT
|Survivor Discussion
|Survivor 43 Episode 10 Discussion Thread || I'm assuming most will be cooking, traveling but the bat will always be here for you
|7 left and at this point who do you want to win? Most likely to win this season? NT
|Please explain why Gab didn't push to take out Jess/Cody instead of Nicole? Gab is right Je/Co about them being the power couple. And why oh why not target men instead of other women? NT
|Young Sheldon
|Young Sheldon 6.8 -Legalese and a Whole Hoo-Ha
|Dancing With The Stars
|Finale Dances and Winner Announcement plus Bonus Clips
|The Jukebox
|The Silver Lining NT
|The Score
|NFL Week 12….
|NFL Thanksgiving Games…. I'll be on travel, enjoy Turkey Day!…
|Anyone else a bit 'underwhelmed' by the Fifa Soccer stuff? I admit I'm starting to appreciate the game more and the 'almosts' but jeeps cripes, we've played 2 games now, iirc, Wales and England, and
|Animal House
|Per a logo on my Animal Planet, the Pitbulls and Parolees Series finale airs tonight at 9 PM. NT
|This is a very catty story:
|September 19, 3:48 PM (Cam 3&4) Monday
Brit warns Taylor to be careful bc Monte is still pissed about headphones. He'll take Turner out of spite. Taylor knows M&T won't take her
|September 19, 1:20 PM (Cam 3&4) Monday
Monte fills Turner in on Brittany's 'rant', she went off the rails. Homie Taylor talk, her power trip. He's taking a step back.
|September 19, 12:18 PM (Cam 1&2) Monday
Brittany campaigns to Monte to stay. She wants him to look at it as a podcast.
|September 19, 2:56 AM (Cam 3&4) Monday
Taylor wants Monte to layout a plan for their future relationship. Will they get to know each other outside of the house? Does Monte actually like her?
|September 19, 2:01 AM (Cam 3&4) Monday
Monte talks to Taylor about her actions that made him mad at her. He's not sensitive, it's her tone
|September 18, 10:40 PM (Cam 1&2) Sunday
Monte tells Turner the reasons he doesn't want to hook up with Taylor anymore. ...
|View More...


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A loveseat sofa bed is a convenient piece of furniture for owners who try to avoid wasting numerous houses. A love seat takes up much less space than the traditional 3-seater sofas, which makes it particularly versatile. This simply means that owners can transfer half the round to stream only in one area. Loveseat sofa beds are convertible into a bed, providing additional seating space in your home as well as additional beds for sudden nights. There may be many designs and types. Most likely, the most common have hidden the frame of the bed under the cushions of the couch.
A double lens device
A love-sleeper is a doubly usable piece of furniture that is currently very much appreciated. If you happen to be integrating one into your home, you should consider that this set-up helps you to learn which choices can be made for you.
While armchairs are generally referred to as those plush seats that may only accommodate the head of the household, nowadays armchairs are available in fashionable designs that blend better with all these different living room furniture. This makes the lounger not only a comfortable fit for the whole family, but also for anyone to be proud of.
Loveseat Sleeper Options
- This couch is durable and sturdy; Deterioration will not happen easily.
- It can be placed anywhere you need it because it can be easily transported anywhere.
- It is extremely comfortable and warm, so when opening it is a normal wooden bed.
- It can be used very well as a sofa to rest and sleep.
- It uses the house only minimally – it effectively cuddles in a tiny house.
- Space is not a disadvantage as many of these cabriolets may be empty.
- The available designs are modern, typical and typical of the country. Microfiber, leather based and so on. But then leather can be used as it fits every living space.
Along with the above-mentioned fashions, various types that should be considered best are the sectional sofas for love seats, which are only suitable for those who want to optimize the available home of their home.


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Account Manager
Dublin, IE, D12 P651
We are Allianz Partners. The leader in assistance and insurance solutions in the areas of international health, assistance, automotive and travel insurance. Allianz Partners is a global family of over 19,000 employees across 78 countries. This role is in the International Health part of the business, which has a number of well-known customer facing brands such as Allianz Care, NEXtCARE and Medi24.
The International Health line of business provides international health, life and disability insurance and services, reinsurance and administration services to a wide range of customers. These include multinational companies, intergovernmental organisations (IGOs), non-governmental organisations (NGOs), private individuals, families and students. Our mission is to ensure that customers have access to quality healthcare through our support, care and commitment to go the extra mile. We are a truly global health partner for our customers, ensuring fast and simple access to the best advice, treatment and value for our customers.
Maintain and develop assigned accounts to ensure positive client experience, renewal and maximise profitability through daily account management
Responsibilities will include, but are not limited to, the following:
Account Management
- Act as the account lead for assigned accounts based on the Client Value Proposition
- Support other account leads on larger clients as second account manager
- Build and maintain good long term successful relationships with the client
- Understand and maintain very good knowledge of the client contacts
- Anticipate future needs, challenges and developments where possible
- Document and regularly maintain all relevant information in Salesforce
- Communicate relevant information to various other areas to ensure they have the necessary understanding to make decisions
- Lead and support any client meetings/calls as and when required, as per the guidelines in the Client Value Proposition, where possible
- Hold and participate in the account review meetings to discuss claims experience, service performance and client feedback as well as possible future opportunities as appropriate to the CVP
- Very good understanding the client's business and requirements
- Provide back up and support to client teams where required
- Recognised as the go-to person internally on the own client portfolio
Client Experience
- Easy, quick and high quality interactions with all touch points and escalation resolution in a swift and client centric manner
- Provide effective, innovative and timely solutions to client's business challenges
- Provide a positive and engaging client experience
- Mainly independently identify and implement efficient solutions to client's requirements and challenges
- Independently manage any escalations to ensure a swift and client centric resolution
- Regularly review and analyse client experience results to identify possible areas for improvement
- Seek, document and share feedback from client on service delivery
- Ensure tailored processes, products and services are documented and optimised over time to improve efficiency
- Boost client stickiness
- Prepare and issue renewal documentation within agreed timeframes
- Independently negotiates renewal internally and externally to achieve favourable outcome for both sides
- Aims to improve profitability for assigned client portfolio
- Ensure regular client engagement by phone throughout the renewal process
- Communicate and document all agreements and requirements for the renewal
- Support tender responses for existing clients to provide a comprehensive and tailored response
New Business
- Support the implementation of new clients ensuring a smooth and seamless transfer
- Support the sales process for potential new clients
- Discover and aims to convert opportunities for cross selling additional products or services
- Other requirements
- Supports or acts as technical representative for team on cross functional projects
- Train new team members
- Supports development and implementation of technical parameters, policies and frameworks for others to work within
To be successful in this position you will need to have the following skills/ experience:
- Minimum of two years work experience in an account management role within a Financial Services environment
- Experience in a customer focussed environment, producing accurate work within tight deadlines
- Completion or progress towards the Irish Insurance Examinations or equivalent foreign qualification
- Good knowledge of MS Office (Outlook, Word, Excel, PowerPoint
- Knowledge of Salesforce an advantage
- A highly customer-focused individual with excellent interpersonal and communicative skills
- Excellent problem solving skills
- A high level of results/goal orientation
- Takes full ownership and responsibility for the task/duties assigned to them
- Very high attention to detail
- Team player & ability to work on own initiative
- Highly motivated and innovative individual possessing the ability to work under pressure and to meet tight deadlines and service standards
- Fully capable of prioritising and managing own work independently
As an equal opportunity employer, Allianz Partners recognizes that our strength lies in our people and we are committed to diversity and inclusivity. So if you would like to be part of a global company that offers international career opportunities, kick-start your career and dare to join us!
For more information, please visit www.allianz-partners.com


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|IPO Open
|Feb 23, 2010
|IPO Close
|Feb 25, 2010
|IPO Price
|Face Value
|IPO Size
|₹324.98 Cr
|Listing At
|Lot Size
The United Bank of India IPO opens on Feb 23, 2010 and closes on Feb 25, 2010.
Sorry the United Bank of India IPO timelines are not available at this time.
The United Bank of India IPO starts on Feb 23, 2010. The issue ends on Feb 25, 2010.
The United Bank of India IPO size is 50000000 Equity Shares of ₹10 aggregating up to ₹324.98 Cr.
United Bank of India is selling its shares to the public through an Initial Public Offer (IPO). Retail investors can apply online for United Bank of India IPO shares through the banks (using ASBA) or through the broker (using UPI).
|Qualified Institutional Buyers (QIB)
|28,500,000 Shares
|Non-Institutional Investors (NII)
|4,750,000 Shares
|Retail Individual Investor (RII)
|14,250,000 Shares
|Employee Reservations
|2,500,000 Shares
|Other Reservations
|0 Shares
|Total Issue Size
|50,000,000 Shares
|Qualified Institutional Buyers (QIB)
|47.08 times times
|Non-Institutional Investors (NII)
|39.15 times times
|Retail Individual Investor (RII)
|9.80 times times
|Employee Reservations
|0.53 times times
|Other Reservations
|Total Issue Size
|33.38 times times
Click here to check the United Bank of India IPO live subscription status.
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Posted by Molly Dore
Buell Realtime Reporting, a court reporting, legal videography firm, needed a social media strategy. Buell Realtime has been providing court reporting services to the legal community for over 20 years and had no social media presence.
Buell Realtime Reporting approached Dore Consulting Group in need of a social media strategy. Dore Consulting Group along with Buell Realtime developed a social media strategy that was the right fit for them. The goal was to expand their online presence which included understanding the right social media tools to leverage and implement consistent branded posts to engage clients.
Dore Consulting Group conducted social media training sessions for staff and after the training implemented a social media strategy. The result was tremendous growth of Buell Realtime's social media presence. In just four months, their social media followers more than doubled, with their post-engagement organically reaching hundreds to thousands of people.


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When You Want The Best Tiling Auckland
Now that the rainfall is a thing of the past and also the sunlight has started to brighten up the city, it's time to begin considering exactly how you are going to decorate your residence or business area with Tiling Auckland. There are many means to include design and course to a room however it needs to be done in such a manner in which it improves both functionality as well as charm.
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The main suspect in the death of a 74-year-old woman who was burnt to death in a house in the Gal Udupita area in Mahabage, Wattala, has been identified by the Mahabage Police as the husband of her only daughter.
Police had received a complaint that burglars had broken into the house between 1.00 am and 5.00 am on June 7, opened the cupboards and boxes, stole the property, killed the woman and had then fled.
The police arrested the woman's son-in-law on suspicion of his behaviour and he revealed the details of the incident during further interrogation.
The suspect had confessed that he had killed his mother-in-law for her wealth, while his wife was receiving treatment at a private hospital in Wattala.
Mahabage Police have found gold jewellery and cash belonging to the deceased hidden in a car parked at the house.
The suspect has been remanded after being produced before the Wattala Magistrate's Court.


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Actor Siddharth, who is known for his active presence on Twitter, blasted Kohli for his poor choice of words used against the fan.
It is not the first instance where a comment by any public figure has creased eyebrows and deepened frowns. India captain Virat Kohli's latest comment over an unflattering opinion by a fan has caused many criticisms.
During a promotional video launching his app, Virat read comments by fans in which one comment read, "He (Virat Kohli) is an overrated batsman. Nothing seems special in his batting. I enjoy watching English and Australian batsmen more than these Indians."
Is #Kohli asking his non-Indian fans to leave their country and come to India🤔🤔.. Or to sort their priorities? #WTF pic.twitter.com/tRAX4QbuZI— H (@Hramblings) November 6, 2018
Kohli's retort to this was, "I don't think you should live in India. Go and live somewhere else. Why are you living in our country and loving other countries?"
While he did add that he didn't mind any sort of dislike towards him, the Indian skipper felt that one should get his priorities sorted before posting such comments.
Actor Siddharth, criticised Kohli for his poor choice of words used against the fan. His tweet read, "If you want to remain King Kohli it may be time to teach yourself to think 'What would Dravid say?' before speaking in future. What an idiotic set of words to come from an India captain! (sic)"
Read Exclusive COVID-19 Coronavirus News updates, at MyNation.
Last Updated Nov 9, 2018, 12:22 PM IST


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Rs. 200 (Inclusive of all Taxes)Rs. 180 10% OFF
Authors Lily Joshi
Language Marathi
Pages 223
Book Format Printed
Publishers Rohan Prakashan
Paryatan Ek Sanjivanee is an interesting travelogue by Dr. Lily Joshi.
Through this book she takes you to different popular tourist destinations like Egypt, Greece, Victoria Falls, Red Wood Forest, Yellow Stone National Park, Scotland and also to some adventurous treks like Annapurna Base camp, Kala Patthar Expedition and Yosemait
Half Dome Trek. She also discusses the importance of fitness for travelling in this book.
See more at: http://www.cart91.com/Travel/Paryatan-Ek-Sanjivanee-id-906302.html#sthash.LreUnioZ.dpuf


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It was 38 degrees outside for my run this morning. Cold by our local standards. Not bad, according to the rest of the country, mostly either brushed or buried in snow, freezing rain, black ice, and/or temperatures with single digits and/or negative values. So where was everyone this morning? I was the only runner outContinue reading "It's Perfectly Cold Out There…So Where Is Everyone?"
Tag Archives: Aging
Mom's Life In A Box
My mother passed away almost 10 years ago, and it was time to finish what we started a few years back: getting rid of the paperwork mountain she collected over the years. My mother did not own a shredder, or a computer, or a belief system that allowed her to part with any piece ofContinue reading "Mom's Life In A Box"


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In the last trail talk, the bench was one of the many benches on the Goderich to Auburn Rail trail (G.A.R.T.) that is now part of the G2G rail trail.
I was surprised when I checked to find that between the start of the trail on West Street and where the trail crosses over highway 21 there are 17 benches. Each bench has a plaque. Starting with the ones on West street are two benches "In loving memory of Elmer + Margaret Jenkins", and" In loving memory of Philip Hugh Feagan" The next benches are "Mary Moore 1906-1995 Mother and Teacher", and "Goderich Lions Club 1996" After N Harbour Road are: "Goderich Lioness Club", "Ralph & Avice Foster ", "Sit and enjoy the view, compliments of Frank and Peter Strickland", "In loving memory of Donald MacEwan from the Scott family", "Eleanor and Warren Robinson 2003", "Toronto Bruce Trail Club", "Mike Dawson Family", "Sit and behold Natures Wonders, The Meladys", "Bruce MacPhee", "Norma –Monte Hall July 8 1999", "In loving memory of Connie Osborn 23 Feb 99" from her friends", "Tiger Dunlop Womans Institute of Ontario 1918-1990", and "For my love Beth John". There are also two more benches if you leave the GART to go to Tiger Dunlop's tomb. The Menesetung bridge was saved by great efforts from local volunteers and many contributions from citizens and businesses. It was opened on July 1st 1992.
The warm weekend of March 5th-6th resulted in a lot of snow melting, but it also increased the amount of ice on the trails. Good icers really grip the ice well and prevent falls, which are more likely to cause severe injury the older you are.
On Saturday I hiked the Maitland trail downstream from River Line. The first time I had been on that section since January 1st. There was mixture of snow drifts, icy patches and good hiking. I saw a pair of Geese on the Maitland river and about 20 golden eye flying up stream. I was surprised to meet three adventurous young women who I believe were hiking on the trail from Londesboro road to Sharpes Creek Line. I am not sure what conditions they found on Snowdrift hill where I had cut some steps in the six foot drift on Feb 25th.
The Tuesday Tromp on March 8th found a winter wonderland on the Sifto loop. It was a pity that only 13 hikers were out to enjoy the wonders.
On Wednesday the Uneven hikers were on the Maitland Trail at the Auburn end, avoiding the section West of Pinery line that had large ice blocks left from the Maitland river floods. There was a lot more snow on the trail than is seen in the Goderich Bayfield area.
At https://www.lambtonmuseums.ca there are reports of 4000 Tundra swans on March 12th and even more on March 15th near Greenway Road south of Grand Bend. Locally I have seen the return of other migrants, i.e. robins, red winged blackbirds and grackles, and saw some Tundra swans on the Maitland river on March 16th .
Saturday March 19th 9 a.m. hike on the Lobb trail leader Patrick Capper .
Saturday March 19th 11 am. All about the Morrison Reservoir, Morrison Dam Conservation Area with Denise Iszczuk ABCA.
Saturday March 26th 7-9pm self guided candlelit walk on the Taylor trail. (no dogs. Donate to light a candle $30,$50 or $100. All proceeds to children's room at Huron Hospice. Donations and more information at www.huronhospice.ca/events. 8 p.m. dedication ceremony at Trailhead
The Hullett parking lot at 80602 was still closed on March 16th as not all the logs had yet been removed.
The Wawanosh Nature Centre trails have now been reopened.
The Falls Reserve is closed until the end of May, except for the Maitland Trail's main trail with white blazes and the blue blazed trail. This is due to work on installing a new septic system.
Tuesday Tromper's meet at 9 a.m.on Tuesdays to hike for about an hour. Contact Al Sanders at firstname.lastname@example.com
Uneven Hikers hike for 1 ½ to 2 hours on Wednesdays or Thursdays, contact Patrick Capper. Both groups meet at 9 a.m. and are open to non-members provided they sign the MTA on-line waiver.
If you have questions or something of interest for Trail Talk email me Patrick Capper at firstname.lastname@example.com.


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This professional office space is comprised of two adjoining suites connected by a functional corridor. Building is currently occupied by one tenant, but it could be demised for two tenants. Total of 12 private offices, 4 bathrooms, 3 storage spaces, 2 conference rooms, a break room, a reception area and lobby. Listing is a sublease through March 31st 2023 with landlord being open to initiating a new lease for the prospective tenant.$1.50 SF/month (NNN)+ est HOA Fees $264/MO+ est Taxes $0.21/SF/MO
Listing Agent: ALEX RHOTEN Courtesy of: COLDWELL BNKR/COMMERCIAL DIV Based on information from Willamette Valley Multiple Listing Service, which neither guarantees nor is in any way responsible for its accuracy. All data is provided AS IS and with all faults. Data maintained by Willamette Valley Multiple Listing Service may not reflect all real estate activity in the market. Updated: 28th November, 2022 4:23 AM (UTC)


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Dancers wishing to take their skills to the next level have a new studio to frequent in Lehigh County.
Next Level Dance Academy, offering a variety of dance classes such as ballet, modern, tap and jazz, opened July 6 at 6299 Route 309 in Heidelberg Township, according to a news release.
The 900-square-foot studio, with a tagline of "tradition, precision, grace," is operated by founder and director Savannah Zerff, who enjoys sharing her knowledge and passion for dance with the next generation of students.
Zerff, who began dance training at age 3, attended the Pennsylvania Governors School of the Arts in 2006 and the Alvin Ailey American Dance Theater summer dance program in 2007.
She received a bachelor of fine arts degree in dance from Brooklyn's Long Island University, studying under Dana Hash Campbell, former principal dancer for the Alvin Ailey American Dance Theater; Sara Neece, former ballet master for the Robert Battle Dance Company; and Nathan Trice.
Business Buzz
During her freshman year of college, she was chosen to perform a duet choreographed by Alenka Cizmesija, and in her second year, she received the lead role of Giselle in Donald Byrd's work, Life's Situations, staged by Stephanie Guiland Brown.
Additionally, she performed works choreographed by Robert Battle, Ronald K. Brown, Urban Bush Women, Earl Mosley and Roger Belman, among others.
Next Level Dance Academy, featuring Marley vinyl and spring sub-flooring that gives on impact and sinks slightly when a dancer lands from a jump, aims to provide "next level dance instruction and instill an appreciation for the art of dance in a safe studio environment."
"Our goal is to also help the students grow into mature and respectful humans in and out of the dance studio," the business' mission statement continues.
Summer classes, including ballet, modern, tap, jazz, contemporary and hip-hop, continue through mid-August, while fall sessions will kick off in September and run through June, concluding with a June recital each year.
Students are placed in classes based on their age/grade, and pre-school classes for ages 3-5 are also available. Classes are $13 each and pre-paid one month at a time.
Next Level Dance Academy, located in the Star Plaza at Routes 309 and 100, also offers adult dance cardio/conditioning classes on Saturdays. For more information, call 610-392-1488 or visit nextleveldanceacademy-pa.com.


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Former "Apprentice" contestant Summer Zervos dropped her defamation lawsuit against former President Donald Trump on Friday.
A filing in Manhattan Supreme Court said the case was dismissed and discontinued without prejudice, meaning Zervos could not file the same claim in state court in the future.
Both parties were ruled responsible for their own costs after four years of litigation.
Zervos, during the 2016 presidential campaign, accused Trump of groping and kissing her against her will in a Beverly Hills hotel in 2007 while she was on the TV show.
She sued the then-president in 2017, claiming he had defamed her when he publicly called her a "liar" and said her accusations were "totally made up stuff" and "fake news."
Her attorneys, Beth Wilkinson and Moira Penza, said that "after five years, Ms. Zervos no longer wishes to litigate against the defendant and has secured the right to speak freely about her experience."
"Zervos stands by the allegations in her complaint and has accepted no compensation," they said in a statement.
Trump's attorney, Alina Habba, called Zervos' decision "prudent."
"She had no choice but to do so as the facts unearthed in this matter made it abundantly clear that our client did nothing wrong," Habba said in a statement.
"It is so sad when things like this can happen, but so incredibly important to fight for the truth and justice. Only victory can restore one's reputation!" Trump said in his own statement.
With Post wires
Source link


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The 2021 Horry County Museum Documentary Film Series continues with the SCETV film "Steel Roads, Iron Men"
The Horry County Museum 805 Main Street, Conway, South Carolina 29526
This film, part of the Carolina Stories Series by SCETV, takes viewers on a nostalgic journey through railroading in South Carolina. From the early days when the giant locomotives were steam driven, to the modern world of diesel powered trains, hear railroading stories from the men who drove the spikes or manned the engines from the early 1940s to the present.
The film is free to the public and will be shown at 1 p.m., Wednesday, Sept. 8, at the Horry County Museum, located at 805 Main Street in Conway.
The Horry County Museum Documentary Film Matinees will continue throughout 2021. For a full list of films, visit our website at horrycountymuseum.org. For more information, call the Horry County Museum at (843) 915-5320 or e-mail firstname.lastname@example.com.


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Severe storms including tornadoes are possible from eastern Texas across the Deep South later this week, putting millions of people at risk, forecasters said Wednesday.
More than 9 million people live in parts of Texas, Oklahoma, Arkansas and Louisiana where there is an enhanced risk of severe weather on Friday, according to the Storm Prediction Center.
The threat moves eastward Saturday, with the potential bullseye covering millions of people across much of Mississippi and Alabama, plus parts of eastern Louisiana and the Florida Panhandle. Storms could reach as far north as the Ohio Valley.
Heavy rains are possible in addition to damaging winds, according to the Storm Prediction Center. Many streams already are at or near flood levels because of earlier storms.


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🌸 Title: Harley Merlin
🌸Author: Bella Forrest
🌸Published: August 27th, 2018
🌸Genre: YA, Fantasy, Fiction, Mystery, Paranormal
🌸Preview: A Harry Potter lookalike with glaringly obvious Harry Potter tropes that don't work.
🌸A no major spoilers review.
Harley Merlin can sense people's emotions and works at a casino in order to make use of these powers. A monster arrives after working at the casino and she meets Wade Crowley, a warlock. Harley decides to involve herself in the world of magic when attempts on her life come to fruition and Wade's convincing pitches work. Can she find whoever is after her?
Harley Merlin and the Secret Coven attempts to market itself as a Harry Potter lookalike, but instead is just a worse version of it and attempts to copy multiple plots. Attempting to be original, sadly, it became unoriginal quickly.
Harley Merlin started off nicely, and I thought it was extremely interesting that this character was using her empathy abilities in a casino. It was a unique, fresh take on magic usage, and I really wanted that to be explored.
Sadly, it wasn't. Instead, Wade starts to make cards magically show up around her in an attempt to make her want to come to the magic world.
So Harley takes Wade's card invitation and leaves to go to the magic world. Goodbye fun casino, hello boring hidden magical world. I'm not joking.
The only reason I did not DNF this book at this point was that I wanted to see if the plot went back to the casino world instead. Sadly, it did not.
It was a glaringly obvious attempt to make Harley Merlin seem Harry Potter-esque, but instead, it seemed weirdly out of place.
After leaving the casino, the entire book lost momentum, making the Harry Potter-like scenes unrealistic. Stale and boring, Harley Merlin attempts to be a magical world when it could have been something more.
The characters lacked in development and were one-sided and boring.
Harley Merlin fails to deliver interesting characters that hold my attention.
I understand there are more books—20, in fact—but you have to give us some reasons to like these characters in the first place. It's a given that she's in the "ragtag" group of people, but how in the world does Wade fit in there? It didn't make sense to me.
Connecting to Harley was an impossible feat. Too much happened and we didn't obtain any background about anyone.
I understand that this is a long series. But the first book in a series is crucial, and that first book in Harley Merlin failed to rein me in.
It fails to become a more "adult" Harry Potter and instead makes it seem like they're even younger than the Harry Potter characters with their childish bickering.
Seemingly written by an 8th grader, Harley Merlin fails to appeal to a Young Adult audience as expected. A middle school audience is appropriate.
This is exactly where you belong, Harley Merlin. A Harry Potter for adults my a**.
Like this review? Check out my other reviews on my blog here.
FTC: not a sponsored post. Some links above are affiliate links – it doesn't cost you any extra, and I earn a small percentage of the sales via those links!


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It will be such a joy when you don't have to drive a few times to such as countertops, sinks, and replace your bathroom flooring. Whether it is short or long-term renovation plan, you must create a strong budget specific steps for how to complete home improvement projects and renovations. You can add study table, comfortable sofas and a does the story end: Will the cost of renovation that can hold its valve if you need to sell? Material Options - Clad Wood Vinyl Clad windows are be more but you will also have the added expense of a new header.
If you are seeking thank you pinterest that... Read more


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Yellow Refresh Button→ Caching
The refresh button is yellow
If your report is # days old. This could just be clearing the cache.
Caching allows Profit diagnostix to 'remember' what a report looked like for a few days and load it up quickly from memory rather than run all the calculations again.
Navigation: Go to main menu → My Dashboards → Any dashboard
Instructions to refresh the cache
If a report is cached, you will see the yellow button with a number in the middle - this indicates how many days old it is. Click on the yellow circle and it will update
If the button is green, it means it is up to date and 0 days old.
Related Articles


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Double-pointed-needle-free and soft as can be in our wonderfully cozy Gentle Giant, we are pretty grateful for such a happy solution to the quick-knit quandary... Happy Hats all around! Our Happy Hat Bundle includes enough big, wonderful, squishy Gentle Giant for two baby- or kid-size hats, if you switch the colors of the stripes, or two adult-size hats, if you also add an extra skein of the main color. Choose from seven happy color combos, and don't forget an Extra Large + Jumbo Pom Pom Maker Set!
Our Happy Hat Bundle includes…
One bundle will make two hats with pom poms if you swap Colors A and B. Adult sizes need to also add an additional skein of the Main Color.
You will also need…
7 stitches and 10 rounds = 4 inches in stockinette stitch
Baby (Kid, Adult Small, Adult Large)
Addi Turbos are the ultimate circular needles for speedy, snag-free knitting! Click here to see our full range of sizes and lengths, or click Add To Basket to purchase these US 17, 16-inch needles for knitting up your very own project!


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Sealing granite countertops can make them look fresh and last longer. When deciding between granite and other countertop materials, many homeowners choose granite.
Does granite need to be sealed?
Yes, granite needs to be sealed. Regularly sealing granite protects it from stains, scratches, and other damage. Many homeowners protect their granite countertops once or twice a year. But you may seal them more often if you like. It generally takes 24 hours to seal it perfectly.
You'll need to learn more about how to finish the whole procedure. That's why we've broken down each step and explained why it's essential.
As a result, we hope you'll stay a while!
Why Should Granite Be Sealed?
Granite is impervious to moisture, yet it is also porous. The pros and cons of granite countertops are pretty visible. Sealing isn't necessary for most granite countertops except for some.
Here are describing some reasons why granite sealing is essential:
- The stone withstands dirt and spills that might cause etching and stains.
- To prevent liquids from penetrating the granite, sealants must be used. Liquids will bead up on an adequately sealed countertop.
- Cooking oil and grease, as well as colored liquids. (Such as red wine and grape juice), may stain the countertop.
- Another common cause is pizza oil. That seeps from the pizza box and coats your counters.
To avoid these problems, granite sealing is essential.
What Are The Advantages of Sealing Granite Countertops?
Sealed granite countertops are easier to clean. You won't have to use abrasive cleaners when you do.
You'll benefit from a cleaner work surface for a longer time. The porous nature of granite makes it a breeding ground for germs.
Sealing also reduces the number of fractures. And crevices where these organisms may thrive there.
You may clean granite using mild soap and water and countertop cleaning solutions. Even though we don't suggest using products that include bleach, ammonia, or acids.
You can also add cabinets to your kitchen for extra beauty.
How to Seal Granite Countertops?
Before you seal your granite countertops, be sure you test their absorbency. A sealer can assist avoid severe damage to your countertops if they absorb any oils or liquids.
A suitable sealant will give you ample time to clean up accidents before they discolor your counters.
Moreover, just like Thoroseal and Drylok wall coatings, there are many countertop sealers available. That's why be sure to pick the right one.
Step 1: Do a Water Test
A simple water test may tell you whether you need to seal your counters or if they're already sealed. To get started, follow the instructions listed below:
- Sprinkle your granite counter with a quarter cup of water and let it dry.
- Please keep track of the water's flow from the time it was poured until it was absorbed.
- There is no need to seal if water does not absorb and is instead repelled.
- Granite countertops should be sealed if water is absorbed and leaves a black stain.
Here is how to conduct a water test properly. This will determine if you need to seal your granite countertops now.
Step 2: Examine the Sealer's Directions
Simply for your information, go over the directions and warning labels. Instructions differ from sealer to sealer, so pay attention to them.
Step 3: Cleaning Granite Countertops
Before sealing your granite countertops, you must clean them. Without cleaning them your countertop won't sit properly.
Step 5: Use an Even Application of Sealer
Spray or apply a liberal quantity of sealer on the countertop with a spray bottle. Let it sit for twenty minutes. Within this time, the sealer will soak into the granite stone.
Before getting a sealer make sure it hasn't expired. Because countertop sealers can go bad just how grout sealers go off.
We attempted to provide you with some high-quality sealers in this section to assist you:
Step 6: Remove The Sealer By Wiping It Off
You may have to reapply the sealer once you're done with the first coat. Certain sealers need a second application, so check the label for details.
Step 7: Wait 48 Hours Before Using the Counter
Allowing the sealer to dry is super important. Make sure you leave your countertops alone for at least two days. Otherwise, you might create a mess.
If you don't want to wait too long, you use the help of a fan. But don't place it too close to the countertop.
After following all of the directions, you should be able to seal your granite countertop.
Question: How often should granite be sealed?
Answer: You seal granite countertops every "6-12 months" or "3-5 years". This is a recommendation from certain professionals. But there is no set guideline.
Question: How much does granite countertop sealing cost?
Answer: The average cost of granite sealing materials in the United States is $0.19 per square foot. Ranging from $0.18 to $0.20. Costs range from $0.77 to $1.63 per square foot combined. With a price range of $92.54 to $195.51, the average 120-square-foot project costs $144.03.
Question: Is linseed oil safe to use on granite?
Answer: Lemon and linseed oils both stain granite. In this scenario, we would suggest that you use mineral oil instead of citrus oil.
That's everything we had regarding whether granite needs to be sealed. The visual appeal of granite countertops is incredible.
If any problem persists after sealing, seek expert help.
Best of luck!


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Thank you to everyone who supported this event, we are grateful for your generousity.
The Start Talking Cup was created to shine the spotlight on the mental health of young hockey players and youth in our community. Through this event, our goal continues to focus on breaking the stigma associated with mental illness and addiction and encourage everyone to "start talking" about how we are feeling.
This year we are proud to host the Minor Midget AAA Barrie Colts vs North Central Predators. The second important piece of this event is each player, parent and coach are offered workshops focused on mental health and addiction awareness. These workshops are provided by our own CMHA SC Youth Counsellors. Over the last 6 years, we have provided this education to over 800 participants.
Please have these items ready to enter the facility;
Completed COVID-19 Screening Form from the City of Barrie
Proof of Vaccination & Valid ID
Proceeds from this event benefit our Start Talking Campaign. Funds raised by this campaign stay in Simcoe County. Start Talking is a CMHA SC awareness initiative working to reduce the stigma surrounding mental illness and addiction while increasing resources for members of our community. Such resources may include education and support focused on suicide prevention, mental health wellbeing and addiction awareness.
Tickets will be available prior to the game for $5.00 and can be purchased online or will be available at the door.
Sponsorship Opportunities available
Jan 20, 2022
Holly Community Centre
171 Mapleton Ave, Barrie ON L4N 8T6


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what to do about the liberal media that claims that conservatives such as the Koch Brothers are "buying the American people". There is far more money saturating the political scene that comes from George Soros, Tom Steyer, the CEO of Dream Weaver, and Hollywood. Guess who is trying to buy Americans? Published in General
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There are estimated to be 2,400 one-horned rhinos, out of a global population of 3,300, at the park in Assam
The seven-day India-Bhutan tour of the Duke and Duchess of Cambridge, Prince William and Princess Catherine, which commenced with their arrival in Mumbai on Sunday, will conclude in spring-awash Ka
Rhino has become a major election issue in Assam this time. It is the precious one-horned rhinoceros that stands out in Assam's wildlife protection areas, especially Kaziranga National Park.
GUWAHATI: Assam's Orang national park, a postcard-size protected area about 150 km from here, has been declared as the tiger reserve, taking a step forward in long term big cat conservation in Assa
JORHAT: Third rhino has been killed by poachers in last 40 days in Kaziranga National Park of Assam, a senior forest official said on Tuesday.
Jorhat/Guwahati: Assam's Kaziranga National Park has lost two rhinos to poachers in four days. With this, the number of rhinos killed this month has risen to three.
GUWAHATI: Kaziranga National Park, a Unesco world heritage site about 250km from here, lost its second rhino to poachers in two weeks on the first month of new year.
There are different categories of activists- some are selfless and voluntary in their activism, while others love to do the act of activism for the sake of earning their 'minute of fame' in the arc
Order of the National Green Tribunal in the matter of Rohit Choudhury Vs. Union of India & Ors. dated 16/12/2015 regarding obstruction of Upper Dihing East Elephant Corridor by building a golf course, Kaziranga National Park, Assam.
The National Green Tribunal today refused to stay its order restraining Numaligarh Refinery Limited from carrying out any construction activity in the no-development zone in Kaziranga National Park
Forfeiting our commons
The Lancet's Series on Maternal and Child Undernutrition
President Obama's grand climate plan does not add up
Climate change can no longer be ignored
NGO demands withdrawal of Niyamgiri gram sabha notificatio


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This site is so full of awesome
some great gifs over there as well
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<< so Maggie is on some pills for her eye bump. They make her drink a lot of water and piddle a bunch. It was a pissapoloza this morning and I have an amazing ability to locate the puddles even with sleep gunk in my eyes with my feet.


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Swissport is growing its business in Asia through the extension of key partnerships in Japan and South Korea with Lufthansa, Cathay Pacific, FedEx Express Korea, Air France and KLM.
In addition to renewing its contract with Air France, KLM and Air Calin at Japan's Tokyo Narita airport, Swissport has been providing handling to Air France and KLM at Seoul Incheon in South Korea, and ground services to Air France at Tokyo Haneda since June.
"Swissport Japan has been proudly handling Air France KLM for three years," said Toralf Sonntag, Swissport Senior Vice President Asia.
"and we are delighted to expand our footprint to Haneda and Incheon."
At Narita airport (NRT), Swissport supports a daily flight each for Air France and KLM and five services a week for Air Calin.
The additional locations expand an already strong global partnership which sees Swissport support Air France, KLM and Air Calin at 33 airports across 12 countries.
In South Korea, Swissport has also extended its 15+ year partnerships with Lufthansa and Cathay Pacific.
"Thanks to consistent and award-winning performance, and following a long and competitive tender process, Swissport Korea is proud to continue its partnerships with Lufthansa Group, Cathay Pacific and FedEx Express Korea," Mr Sonntag said.
"This is a great achievement for Swissport Korea and we are honored to continue to provide our exceptional services and be a reliable partner to our valued customer airlines."
At Seoul Incheon Airport, Swissport provides cargo and freighter ramp services to Lufthansa Cargo, passenger, ramp and cargo services for Cathay Pacific, and ramp freighter and cargo warehouse handling for FedEx Express Korea.


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Secret identities are not the only thing masks protect - turns out our faces are getting a bit of a boost as well with this new lot
The Masked Wonders
Almond milk
At the rate we're bombarded with revolutionary products - we should be living in the future with flying cars and a dystopian overlord. Thank god, the only futuristic deals we have to cope with are some pretty awesome beauty products. The latest to join the brigade is Bobbi Brown's compact, but effective, range of face masks, the Mask Trio Collection. You can smear them on depending on your skin type, or mix and match depending on your current concern. But Bobbi also believes that make-up is only as good as the canvas on which it's applied. To help you achieve this Brown has collaborated with Tricia Williams, her go-to nutritionist and chef to give customized recipes to go with each of the mask. Keep scrolling to get the recipes and read our review of the face masks.
A clay mask that squeezes out beautifully smooth and supple. It comes in a tube - therefore fewer risk of impurities (like dipping your dirty digits into a pot), hurray. Beauty's crush of the moment is clay - Amazonian, volcanic, bentonite - extremely efficient in drawing and soaking up excess sebum, dirt and grease, leaving behind smooth and super clean skin. This one is a particular hit with us, thanks to our tropical weather. We've been rushing home, if only to quickly spread it across our face, leaving it on for five minutes and then washing it off. Yes, it's that simple.
For best results have a serving of the Deep Winters Greens Soup
You will need (for four servings):
2 tablespoon avoacado oil2 cloves garlic, smashed
1/2 teaspoon fresh ginger, minced
1/2 cup white onion, chopped
1 carrot, diced
2 celery stalks, diced
4 cups vegetable stock
Pinch of cardamom
2 cups baby spinach
2 cups kale, stemmed
2 cups swiss chard, stemmed
Pinch of Hawaiian Sea Salt
Pepper to taste
2 teaspoons grass fed butter (optional)
In a medium pot, heat avocado oil over medium heat. Add garlic, ginger, onion, carrot and celery. Sautee until onions are translucent. Add vegetable stock, cardamom, spinach, kale, swiss chard, salt and pepper. Bring mixture to a boil and then remove from heat. Let it cool for a few minutes before pouring mixture into a blender. Add grass fed butter with mixture in the blender. Puree until smooth and creamy.
A mask which is effectively a heavy night cream - we love night masks especially because they're such an effective barrier against our nightly air-con. This one has some beautifully hydrating ingredients like coral grass, a wonderfully hydrating gift from the seas, and chlorella extract, a green algae that increases collagen production, and muru muru butter for some plump moisturisation. In plain talk, it's an intense dose if your skin's been dry, parched, patchy and peel-y. We've been using this once a week - it's heavy duty given our weather, but much needed thanks to the effects of pollution and air conditioners on our skin. Massage it in gently and nod off.
For best results have a serving of the Dark Chocolate Coconut Cluster Powder Bar
You will need (for 16 bars):
1/2 cup almond butter
1/2 cup honey
1 cup rolled oats, toasted
1 cup puffed brown rice
1/2 cup sliced almonds
1/2 cup shredded unsweetened coconut
1/3 cup dark chocolate chips
Pinch of sea salt
Grease an eight-inch square pan with a little oil and line with parchment paper.In a small sauce pan, heat the honey and almond butter for three minutes or until thoroughly melted. In a medium bowl combine oats, cereal, almonds, coconut, dark chocolate chips and sea salt. Pour the honey mixture into the dry mixture and stir until well combined. Place into pan. Using wet hands, press the cereal bar mixture down until it is flat and even. Then place pan in the fridge to set for at least 1 hour. Remove from pan and cut into 2 x 1 inch bars. Bars can be stored in an airtight container for up to two weeks.
Turns out sometimes we don't need the army of tinted moisturisers, bronzers and highlighters for a glow. Our freshly scrubbed skin might just be enough. The Radiance Boost mask is kaolin clay (magic eraser of excess oil and deep cleanser of pores) and superfine walnut grains to exfoliate. There's also a fair amount of sodium hyaluronate (that holds an amazing water of water in its molecules giving you a hydrated appearance) and algae extracts to stay on and leave behind decent moisturisation. Wet face, scrub gently, leave on, wash off - paint the town your choice of colour.
For best results start your day with the Quinoa Porridge Breakfast Bowl
You will need (for four servings):
1/2 cup quinoa
1/4 teaspoon ground cinnamon
1 ? cups almond milk
Small piece kombu
1/2 cup water
1 tablespoon coconut sugar or maple sugar
Pinch of sea salt
1/3 cup crushed walnut
1/2 teaspoon of orange zest
Heat a saucepan over medium heat and measure in the quinoa. Season with cinnamon and cook until toasted, stirring frequently, about 2 minutes. Pour in the almond milk and water, then stir in the coconut sugar and salt. Add piece of Kombu. Bring to a boil, then cook over low heat until the porridge is thick and grains are tender, about 25 minutes. Add more water, as needed, if the liquid dries up before it finishes cooking. Stir occasionally, especially at the end, to prevent burning. Remove from heat. Discard Kombu. Top with crushed walnuts and orange zest.
*The masks are lightly fragranced, so those with sensitive skin should test it first before trying. The Radiance Boost has small granules, so those with acne prone skin should avoid zealous exfoliating.
Bobbi Brown Face Masks, Rs 3,570


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In 2017 Cleveland Clinic provided $906.5 million in community benefit – including financial assistance, Medicaid shortfall, subsidized health services, outreach programs, education and research – the highest level in our reporting history.
The total – a 5 percent increase over 2016 – includes all health system operations in Ohio, Nevada and Florida.
"Cleveland Clinic is committed to creating healthier communities," said Tom Mihaljevic, M.D., CEO and president of Cleveland Clinic. "Our community benefit is far-reaching, including healthcare access for everyone in our communities; the education of the next generation of healthcare professionals; free prevention and screening programs; and medical research that leads to advanced treatments and cures."
Cleveland Clinic calculates community benefit conforming to the IRS Form 990 reporting guidelines, which include activities or programs that improve access to health services, enhance public health, advance general knowledge and relieve government burden. The primary categories for assessing community benefit include financial assistance, Medicaid shortfall, subsidized health services, outreach programs, education and research:
Financial assistance ($90 million)
Financial assistance increased 4 percent over 2016 and includes free or discounted care provided to patients who are unable to pay some or all of their bills. Cleveland Clinic's financial assistance policy provides free or discounted care to patients with incomes up to 400 percent of the federal poverty level.
Medicaid shortfall ($406.9 million)
Medicaid provides government-funded healthcare coverage for low-income families and individuals. However, in many states, including Ohio, Medicaid payments do not sufficiently cover the costs of treating Medicaid beneficiaries. In 2017, Cleveland Clinic's Medicaid costs were $406.9 million – a 7.1 percent increase over 2016 – including an $8.3 million net contribution to Ohio's Hospital Care Assurance Program (HCAP). (The 2016 Medicaid shortfall has been revised upward to properly reflect costs which were previously understated.)
Subsidized services ($22 million)
These are clinical services provided to meet the needs of the community despite creating a financial loss for the hospital system, such as behavioral health, obstetric and chronic disease management, among others. The 2017 total represents a 12.4 percent increase from 2016.
Health professions education ($280.9 million) and research ($70.6 million)
Costs for training health professionals – medical residents, fellows, nurses and allied health professionals – increased 3.2 percent from 2016 to 2017, while research expenses increased 10.3 percent.
Outreach programs ($36.1 million)
Cleveland Clinic's outreach programs align with the local needs identified in the hospitals' Community Health Needs Assessments, with an emphasis on prevention, wellness and chronic disease management. Examples include:
- The Stephanie Tubbs Jones Family Health Center provides programs which teach community members about prevention, wellness, nutrition and behavioral modification. Navigation services connect community members with support programs.
- Community classes and interactive web chats offer health education on chronic disease management in the areas of heart disease, stroke, cancer, diabetes, asthma, brain health, and healthy senior and youth lifestyles.
- The Healthy Community initiatives connect residents with local resources in a collaborative effort to strengthen communities through wellness activities, academic achievement and career preparedness.
- Health fairs – including the Cleveland Clinic Minority Men's Health Fair, Celebrating Sisterhood, Tu Familia, Victory in Pink, and neighborhood fairs – provide thousands of people with free health screenings and educate community members on the benefits of preventive healthcare.
- Collaborative initiatives with community nonprofits and local government address population health issues, such as the opioid crisis and infant mortality.
As a nonprofit hospital system, Cleveland Clinic is a community asset with no owners, investors or stockholders. Any and all extra funds from operations are invested back into the health system to support patient care, research, education, and long-standing charitable efforts.
Read or download the entire report here.


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Cuff Bracelet - Atlantean Mercat
Click Image for Gallery
Atlantean Mercat - Cuffed Bracelet - An Atlantis Mermaid Cat swimming in the ancient ruins of the legendary lost city.
Be sure to check out the Related Products to find matching jewelry!
Classic Style Cuff Bracelets
The cuff bracelets feature an oval bezel with silver plated overlay. My fantasy cat images is set under a clear cabochon. The cabochon measures 25x18mm (about 1 inch tall & 3/4 inch wide with the setting) The cuff easily bends to accommodate different wrist sizes. The bracelets come packaged in a sheer Organza drawstring bag.


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Welcome to our new website! If this is the first time you are logging in on the new site, you will need to reset your password. Please contact us at email@example.com if you need assistance.
Your membership opens the door to free learning resources on demand. Check out the Member Knowledge Center for free webcasts, publications and online courses.
This comprehensive resource covers product change evaluation, postmarket surveillance, audit/inspection compliance, and various other laws and regulations pertaining to maintaining a product on the market.
Hear from leaders around the globe as they share insights about their experiences and lessons learned throughout their certification journey.
Regulatory News | 09 January 2017 | By Zachary Brennan
The European Medicines Agency (EMA) on Monday released for public consultation a new question and answer document focused on the risk-based prevention of cross contamination in pharmaceutical manufacturing and setting health-based exposure limits for risk identification.
The 14 questions and answers hone in on specifics such as "Do companies have to establish Health Based Exposure Limits (HBELs) for all products?" (yes), which products or active substances are highly hazardous, how the HBEL model can be applied to early phase Investigational Medicinal Products (IMPs) where limited data is available and whether HBELs need adjustment if pediatric drugs are manufactured in shared facilities with adult and animal drugs.
At the Q&A's outset, EMA makes clear: "HBELs should be established for all products."
Evidence that a drug product or active substance falls within any of the following five categories should result in a product being considered highly hazardous, EMA says:
In terms of establishing limits for cleaning purposes, EMA also notes that such limits should continue to be based on risk assessments and additional safety margins to help account for uncertainty in the cleaning processes and analytical variability.
"Traditional cleaning limits used by industry such as 1/1000th of minimum therapeutic dose or 10 ppm of one product in another product, may accomplish this for nonhighly hazardous products. For products classed as highly hazardous, where a thorough risk assessment can justify manufacture in shared facilities, cleaning limits should include safety factors beyond the HBEL and should not be higher than the traditional cleaning limits approach," the Q&A says.
Questions and answers on implementation of risk based prevention of cross contamination in production and 'Guideline on setting health based exposure limits for use in risk identification in the manufacture of different medicinal products in shared facilities' (EMA/CHMP/CVMP/SWP/169430/2012)
Tags: hazardous drug compounds, EMA guidance, HBELs