text:
Standley grew up with her family participating in I'Lon-Schka. She also learned traditional cooking from her mother, Debbie Atterberry. Valuing our culture and her heritage so much, Standley used her education in broadcast journalism to interview tribal elders and explore ways to bridge the gap between generations.
Red Corn grew up in Pawhuska, Oklahoma, attending school at Indian Camp. He began drawing at age 6, and has taken his aspirations to an accomplished height as an artist and illustrator. When he is not working on a project, he volunteers at the local Veterans Affairs Hospital where he draws portraits for veterans.
"Frybread for Addie" demonstrates bringing the culture of Standley's own grandmother to young readers and presenting the work of a local Osage artist. Come join us at the book signing as we celebrate the presentation of "Frybread for Addie".
DATE/TIME: Wednesday, March 13, 2013 10:0AM
LOCATION: Wakon Iron Hall, Pawhuska, Oklahoma
This notice is posted in accordance with ONCA 07-53, the Osage Nation Open Meeting Act. The Osage Nation Gaming Enterprise Board may discuss, make motions, and vote upon all matters appearing on this agenda, such votes may be to adopt, reject, table, rescind, or take no action on any agenda item. This meeting is open to the public.
1. Call to Order and Welcome
2. Opening Prayer
3. Roll Call
4. ONGE Board Report
5. Osage Casinos Business Update
6. Osage Professional Leadership Society
7. FY2012 Audit Presentation
8. Expansion Update
9. Closing Remarks
10. Adjourn
Osage Nation
Water Rights Task Force Meeting
March 14, 2013
3:30 – 5:00 p.m.
Osage Nation Congress/Council Chambers
1. Call to Order
2. Prayer
3. Approval of Minutes
4. Water Rights Task Force Mission Statement
5. Discussion of Pending Osage Nation Legislation Regarding Water
6. Discussion Regarding Data Collected/Established Use
7. Field Trip to Industrial Park in Hominy March 18
8. Discussion of Oklahoma Water Law Conference in Oklahoma City May 9-10
9. Discussion of Water Sustainability and Climate Grant
10. Old Business
11. New Business
12. Adjourn
March 15th 2013 10:00 A.M.
Subject to Change
1. Call to order – Welcome by Chairman, Galen Crum
2. Opening prayer
Opening Prayer: Councilwoman Cynthia Boone
3. Roll call
4. Minerals Matters – Charles Hurlburt, Supervisory Petroleum Engineer
5. Administrative Matters – Rhonda Loftin, Osage Agency Acting Superintendent
6. Executive Session –
A. Dan O'Toole- Encana
B. Steve Tyler Jr.- Tyler Oil Company, LLC
C. Bruce Krebbs
7. Old Business -
A. Boone- Negotiated Rule Making
8. New business –
A. Core- Possible hiring of Reta Linter to scan run tickets for the Bureau of Indian Affairs
B. Core- Termination of Attorneys for the Negotiated Rule Making Committee
C. Boone- Field Trip
9. Committee Reports:
1. Improvement Committee - Crum
2. Budget Committee - Abbott
3. Media Committee - RedEagle
4. Liaison Committee - Crum
5. Scholarship Committee – Core
6. Well Plugging Committee - Yates
7. Policy/Procedure – Boone- Committee Policy
8. 1906 Act - Bear
11. Adjournment
The Osage Nation Historic Preservation Office presents
2nd Annual Osage Heritage Site Visit: St. Louis Area
Dates: Monday, March 18 through Friday, March 22, 2013
We will travel to Missouri to experience and appreciate the region's cultural history related to the Osage people. Heritage sites are very often associated with oral tradition and origin stories, trails or pilgrimage routes, gathering and offering areas, habitation sites with structure, artifacts, petroglyphs or pictographs, observatories and sacred calendar sites, among other types of culturally important places.
The trip will take place Monday, March 18th through Friday, March 22nd. We will visit Cahokia Mounds State Historic Site, Big Mound, Sugarloaf Mound, the East St. Louis sites, and Washington State Park. The Cahokia Mounds site is one of only 25 World Heritage Sites within the United States. This is an outdoor event and some activities will require walking on forest trails. Please bring clothing and shoes appropriate for hiking in cool weather. We have chartered a bus for the trip and will be staying in a downtown hotel in St. Louis. We will provide all meals for the entirety of the trip. The trip is limited to 25 Osage Constituents, 18 years or older. Registration is on a first-come, first-serve basis. Registration packet is available at the following link: Registration Packet
Please contact Jen Whitte if you would like more information.
Jen Whitte
GIS Technician
Important dates to remember:
Registration opens: Dec 3rd, 2012
Registration closes: March 1st, 2013
Monday, March 25, 2013 4:00PM
2. Roll Call
3. Establish Quorum
4. Prayer
5. Approve Minutes from Previous Meeting
6. Meet with Osage Nation Treasurer – Ms. Callie Catcher
7. Discuss BIA Indian Energy and Economic Development Program/Review
8. Intensive Tribal Business Review – Profile for Future
9. Review Projects
10. Review By-Laws


text:
» A Culture that Engages Every Family, Steven M. Constantino, Ed.D.
» How to Revitalize Your School-Parent Compact, Marilyn Price-Mitchell, Ph.D.
» How Do You Know if You're Really Open to Partnership, Anne Henderson & Karen Mapp
»PTA--Gateway to Engagement, Advocacy, and Access, Meryl Ain, Ed.D.
» The Power of Asking-Instead of Telling, Jody McVittie, M.D.
» Empathy in Action, Rick Ackerly, Ed.M.
We view achievement broadly, beyond grades and test scores, emphasizing the importance of a child's social, emotional, and intellectual learning and development.
Sponsored by the nonprofit National ParentNet Association, we are a leading resource on engaging families in the education and positive development of their children. Our site offers many free resources, including a growing Consultant Directory of professionals who work with schools in the family engagement field. We are also the home of ParentNet, a parent-led program in schools that engages parents in face-to-face conversations about raising healthy, successful kids in grades Pre-K to 12.
April is Autism Awareness Month: 4 Great Reads from Parents in the Know | |
By Meryl Ain, Ed.D on April 28, 2013 | |
April is Autism Awareness Month. If you are a parent who knows or suspects that your child has autism, there is a large online parent community that will provide you and your child with support and resources. Read more... |
Common Core Standards: What Parents Need to Know | |
By Ryan M. Tracy on March 25, 2013 | |
Leveling the educational playihg field for all students regardless of their zip code is what Common Core Standards are deemed to provide. But we will need the support of our parents to truly initiate these standards in our states. Read more... |
When Parents Advocate for the Right Stuff | |
By Rick Ackerly, Ed.M. on March 7, 2013 | |
When we parents advocate for our children, let's make sure we advocate for the right things. Read more... |
Kindergarten Successfully Launching Your Child Into the K-12 System | |
By Meryl Ain, Ed.D on March 4, 2013 | |
Is your five-year-old going to kindergarten next fall? Here are some tips to make for a seamless transition for you and your child. Read more... |
Alfie Kohn on Parent Involvement in Education | |
By Marilyn Price-Mitchell Ph.D. on February 11, 2013 | |
Alfie Kohn, a highly respected leader in the field of education and parenting, asks some critical questions about parent involvement. Are we so focused on how many parents are involved that we've lost sight of the nature of their engagement? Read more... |
I Don't Think There's an App for That | |
By Dr. Steven M. Constantino on January 22, 2013 | |
With the increased use of technology, social media, and apps for just about everything in our lives, there is a limit to what technology can do to foster real family engagement in schools. While the apps developed for family engagement are impressive, do they really engage anyone? Read more... |
hosted by

subset: commoncrawl


text:
National Cancer Institute®
Last Modified: June 1, 2002
AU - Wiedemann LM; Burns JH; Birnie GD
Differences among the polyadenylated RNA sequences of human leucocyte
populations: an approach to the objective classification of human
AD - The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.
We have constructed a complementary DNA (cDNA) library representing
expressed sequences of the white blood cells from a patient with chronic
granulocytic leukaemia. The library was screened by colony hybridization
of 32P-labelled cDNAs synthesized from the polyadenylated RNAs of the
white blood cells from patients with chronic granulocytic or chronic
lymphocytic leukaemia. The autoradiographic patterns were compared and
70 recombinants were selected to comprise a panel which distinguished
between these two types of leukaemia. Hybridization of this panel with
complementary DNAs transcribed from the polyadenylated RNAs of a variety
of normal and neoplastic leucocyte populations showed that the RNA
sequences in high abundance in leucocytes from chronic granulocytic
leukaemias differ quite radically from those in other leucocytes. The
patterns of hybridization seen when this panel was challenged with cDNAs
representing the RNAs of normal and leukaemic leucocyte populations were
sufficiently different to distinguish clearly the peripheral blood
leucocytes of chronic granulocytic leukaemias from other populations of
white blood cells, both normal and leukaemic. We suggest that this
approach might provide additional markers useful in the classification
of the acute leukaemias, especially the undifferentiated leukaemias
whose identification by conventional methods is uncertain.
AU - Yu ZC; Ding J; Nie YZ; Fan DM; Zhang XY
Preparation of single chain variable fragment of MG(7) mAb by phage
display technology.
SO - World J Gastroenterol 2001 Aug;7(4):510-4
AD - Department of Gastroenterology, Xijing Hospital, Fourth Military Medical
University, Xi'an 710032, Shaanxi Province, China.
AIM: To develop the single chain variable fragment of MG MG(7)murine
anti-human gastric cancer monoclonal antibody using the phage display
technology for obtaining a tumor-targeting mediator. METHODS: mRNA was
isolated from MG MG(7) producing murine hybridoma cell line and
converted into cDNA. The variable fragments of heavy and light chain
were amplified separately and assembled into ScFv with a specially
constructed DNA linker by PCR. The ScFvs DNA was ligated into the
phagmid vector pCANTAB5E and the ligated sample was transformed into
competent E. Coli TG1. The transformed cells were infected with M13K07
helper phage to form MG MG(7) recombinant phage antibody library. The
volume and recombinant rate of the library were evaluated by means of
bacterial colony count and restriction analysis. After two rounds of
panning with gastric cancer cell line KATO III of highly expressing
MG(7)-binding antigen, the phage clones displaying ScFv of the antibody
were selected by ELISA from the enriched phage clones. The
antigen-binding affinity of the positive clone was detected by
competition ELISA. HB2151 E. Coli was transfected with the positive
phage clone demonstrated by competition ELISA for production of a
soluble form of the MG(7) ScFv. ELISA assay was used to detect the
antigen-binding affinity of the soluble MG(7) ScFv. Finally, the
relative molecular mass of soluble MG(7) ScFv was measured by SDS-PAGE.
RESULTS: The V(H), V(L) and ScFv DNAs were about 340bp, 320bp and 750bp,
respectively. The volume of the library was up to 2 X 10(6) and 8 of 11
random clones were recombinants. Two phage clones could strongly compete
with the original MG(7) antibody for binding to the antigen expressed on
KATO III cells. Within 2 strong positive phage clones, the soluble MG(7)
ScFv from one clone was found to have the binding activity with KATO III
cells. SDS-PAGE showed that the relative molecular weight of soluble
MG(7) ScFv was 32. CONCLUSION: The MG(7) ScFv was successfully produced
by phage antibody technology, which may be useful for broadening the
scope of application of the antibody.
AU - Anonymous
Share the risk: revealing the secrets of our genes to insurers doesn't
add up.
SO - New Sci 2000 Oct 21;168(2261):3
AU - Young E
Premium genes.
SO - New Sci 2000 Oct 21;168(2261):7
AU - Goel V
Appraising organised screening programmes for testing for genetic
susceptibility to cancer.
SO - BMJ 2001 May 12;322(7295):1174-8
AD - Department of Health Administration, McMurrich Building, Toronto,
Ontario, Canada M5S 1A8. firstname.lastname@example.com
AU - Gar'kavtseva RF; Kazubskaia TP; Liubchenko LN; Kozlova SI; Belev NF;
Sel'chuk VIu
[Hereditary cancer: identification, genetic heterogeneity,
medico-genetic consult]
SO - Vestn Ross Akad Med Nauk 2001;(9):27-33
The paper deals with a role of inherited factors responsible for the
occurrence of malignant tumors. Inherited types of cancer are shown to
occur virtually at its sites and averaged 5-15%. Formalized criteria for
identifying inherited cancer diseases and their etiological and genetic
heterogeneity are presented. A role of genes that genetically predispose
to particular forms of cancer is shown, which allows for early
(preclinical) diagnosis and prevention of cancer diseases.
AU - Badens C; di Montemuros FM; Thuret I; Michel G; Mattei JF; Cappellini
MD; Lena-Russo D
Molecular basis of haemoglobinopathies and G6PD deficiency in the
Comorian population.
SO - Hematol J 2000;1(4):264-8
AD - Centre d'Enseignement et de Recherche en Genetique Medicale, Hopital
d'enfants de la Timone, Marseilles, France. firstname.lastname@example.com
INTRODUCTION: The Comoro archipelago is characterised by a high
prevalence of red cell genetic disorders such as G6PD deficiency and
haemoglobinopathies, being a region endemic for malaria. Over the last
15 years, the city of Marseilles in France has become the main
destination for Comorian immigrants. This Comorian community includes
patients with sickle cell disease, sickle cell/beta-thalassaemia trait,
thalassaemias and G6PD deficiency. MATERIALS AND METHODS: Allele
frequencies for haemoglobin S, beta-thalassaemia and G6PD deficiency
were determined from neonatal and prenatal screenings of the Comorian
community. Haemoglobin fractions were detected by
isoelectrofocalisation, and the quantitation of HbS, HbA, HbA(2) and HbF
was performed by cation exchange high performance liquid chromatography.
The molecular study involved 31 alleles carrying the betaS mutation (Cd
6 [A-->T]), six beta-thalassaemic alleles and 17 G6PD-deficient alleles,
selected from a group of carriers or affected subjects. RESULTS: Allele
frequencies were 3% for haemoglobin S, 1% for beta-thalassaemia trait
and 9.5% for G6PD deficiency. Molecular analysis had revealed that the
African alleles are predominant, being present in almost all the
subjects studied. Mediterranean alleles were found for all the
beta-thalassaemia mutations and for three G6PD chromosomes out of 17.
CONCLUSION: These data are consistent with the mixed Arab and African
origin of the population of the Comoro Islands, and are of clinical
interest in prenatal and newborn screening plans.
AU - Muller H; Eeles RA; Wildsmith T; McGleenan T; Friedman S
Genetic testing for cancer predisposition--an ongoing debate.
SO - Lancet Oncol 2000 Oct;1():118-24
AD - Division of Medical Genetics UKBB, Department of Clinical-Biological
Sciences, Basel, Switzerland. firstname.lastname@example.com
AU - Burgess MM; d'Agincourt-Canning L
Genetic testing for hereditary disease: attending to relational
SO - J Clin Ethics 2001 Winter;12(4):361-72
AD - Centre for Applied Ethics, University of British Columbia, Vancouver,
British Columbia. firstname.lastname@example.com
AU - Compston A; Sawcer S
Genetic analysis of multiple sclerosis.
SO - Curr Neurol Neurosci Rep 2002 May;2(3):259-66
AD - University of Cambridge Neurology Unit, Addenbrooke's Hospital, Hills
Road, Cambridge CB2 2QQ, United Kingdom.
The increased recurrence risk within families indicates a role for
genetic factors in the etiology of multiple sclerosis. Genes may
influence susceptibility to the development of multiple sclerosis and
the subsequent course of the disease. To date, associations have only
been demonstrated consistently with class II major histocompatibility
complex (MHC) alleles. The relatively low yield from additional
candidate gene studies is only modestly advanced by several whole-genome
linkage analyses, and by the first in a series of planned whole-genome
linkage disequilibrium screens for allelic associations. The aims of
linkage and association are to narrow the search for chromosomal regions
encoding genes for multiple sclerosis and, with information from the
human gene project, suggest new positional candidates. In time, it is
expected that these genes will include some that confer susceptibility
to the general process of autoimmunity, others that are specific for
multiple sclerosis in all populations, some that act only in defined
ethic groups, and those that determine particular phenotypes or shape
the clinical course. These genetic analyses are predicated on the
assumption that multiple sclerosis is one disease; a major part of
future studies will be to resolve the question of disease heterogeneity
in multiple sclerosis. When eventually in place, the potential of this
genetic knowledge for improved understanding of the pathogenesis of
multiple sclerosis and designing novel treatments is considerable.
AU - Burrer CV; Bauer SM
Insights into genetic testing for colon cancer: the nurse practitioner
SO - Clin Excell Nurse Pract 2000 Nov;4(6):349-55
AD - Department of Nursing, Worcester State College, Massachusetts
01602-2597, USA. email@example.com
As new genetic discoveries continue to gain public awareness, patients
will increasingly call on their nurse practitioners (NPs) to discuss
their inherited susceptibility to disease. Genetic testing for colon
cancer can presently identify gene mutations for 2 inherited forms of
this disease, familial adenomatous polyposis and hereditary nonpolyposis
colorectal cancer, accounting for approximately 6% of the cases. By
identifying patients at high risk for colon cancer, NPs can discuss the
benefits of early detection through screening procedures while helping
patients gain insight into the meaning and impact genetic testing can
have on their lives. This article discusses the basic genetics involved
and screening recommendations for those with a hereditary disposition to
colon cancer. Benefits, risks, and limitations are also considered,
along with the importance of the NP in educating and supporting
individuals in their decision making about genetic testing for colon
AU - Thomas SM
Pharmacogenetics: the ethical context.
SO - Pharmacogenomics J 2001;1(4):239-42
AD - Nuffield Council on Bioethics, London, UK.
AU - Munzarova M
Genetic susceptibility to malignant diseases--ethical issues.
SO - Neoplasma 2002;49(1):1-4
AD - Institute of Medical Ethics Medical Faculty, Masaryk University, Brno,
Czech Republic. firstname.lastname@example.com
Ethical problems connected with genetic testing with the intention of
the measurement of the susceptibility or predisposition to malignant
tumors are presented (respect for autonomy, beneficence, nonmaleficence,
confidentiality, privacy, veracity and truth-telling, informed consent,
right to know, right not to know, informational self-determination,
etc.). Various aspects dealing with ethics of screening and research
projects involving human subjects are discussed as well.
AU - Taub JW; Konrad MA; Ge Y; Naber JM; Scott JS; Matherly LH; Ravindranath
High frequency of leukemic clones in newborn screening blood samples of
children with B-precursor acute lymphoblastic leukemia.
SO - Blood 2002 Apr 15;99(8):2992-6
AD - Division of Pediatric Hematology/Oncology, Children's Hospital of
Michigan, Detroit, Michigan 48201, USA. email@example.com
The detection of leukemia cells on newborn genetic screening cards
("Guthrie cards") of a small group of patients and several sets of
identical twins developing acute lymphoblastic leukemia (ALL) with
identical phenotypic and chromosomal markers has provided evidence that
childhood ALL cases may arise in utero. We conducted a retrospective
study of a randomly selected group of childhood B-precursor ALL patients
to determine the frequency of the presence of "leukemic" clones
prenatally in ALL cases by testing newborn screening cards. The 17 ALL
patients analyzed had a median age of 46 months (range, 18 months to 13
years) and had median presenting white blood cell (WBC) counts of 10
950/microL (range, 2900-70 300/microL) at diagnosis. A clonal
rearrangement of the immunoglobulin heavy chain (IgH) gene was
identified in diagnostic lymphoblasts and sequenced and patient-specific
primers were used to amplify DNA from blood samples on the patient's
newborn screening cards. Twelve of the 17 (71%) analyzed newborn cards
had detectable IgH rearrangements amplified by seminested polymerase
chain reaction. DNA sequencing confirmed that the IgH rearrangements
detected matched the IgH sequences identified from diagnostic leukemia
cells, indicating the presence of a "leukemic" clone at birth. There
were no differences in age or presenting WBC counts between the cases
with or without positive newborn screening cards. All 6 patients with
hyperdiploid ALL had detectable "leukemic" clones on their cards. The
results of our study support the notion that a high proportion of
childhood B-precursor ALL cases arise in utero, although postnatal
events are also important factors in leukemogenesis.
AU - Hangaishi A; Ogawa S; Qiao Y; Wang L; Hosoya N; Yuji K; Imai Y; Takeuchi
K; Miyawaki S; Hirai H
Mutations of Chk2 in primary hematopoietic neoplasms.
SO - Blood 2002 Apr 15;99(8):3075-7
AU - Foulkes WD; Rosenblatt J; Chappuis PO
The contribution of inherited factors to the clinicopathological
features and behavior of breast cancer.
SO - J Mammary Gland Biol Neoplasia 2001 Oct;6(4):453-65
AD - Department of Oncology, McGill University, Montreal, Quebec, Canada.
This review is focused on genetic factors that may influence the
development and/or appearance of breast cancer metastases. Over the last
decade there have been significant advances in the understanding of
genetic predisposition to breast cancer. The first breast cancer
predisposing gene to be identified was TP53, and this was followed over
the next 5 years by two more genes, BRCA1 and BRCA2, which from a
population perspective are much more important than TP53. Other rarer
genes have subsequently been identified, but the role of more common,
less penetrant genes in breast cancer susceptibility remains unknown.
Recent work has shown that breast cancers occurring in women carrying
germ-line BRCA1 mutations tend to have clinicopathological features that
are usually associated with a poor prognosis, such as high grade,
estrogen receptor negative status and somatic TP53 mutations. On the
other hand, they are usually ERBB2 negative. Whether or not such tumors
are more or less likely to metastasize, and hence be associated with a
poor outcome, is currently uncertain and has been the subject of much
debate. Here, we outline some of the clinicopathological features of
hereditary breast cancer, discuss the prognostic studies that have been
performed, and introduce some possible new research directions.
AU - Trifonov I; Todorova M; Uzunova Zh
[Hereditary ovarian cancer]
SO - Akush Ginekol (Sofiia) 2001;41 Suppl 4():3-7
AU - Brady T
The ethical implications of the Human Genome Project for the workplace.
SO - Int J Appl Philos 1995 Summer;10(1):47-56
AD - Business Adminstration Division Head, Holy Family College, Philadelphia,
AU - Njajou OT; Vaessen N; Oostra B; Heutink P; Van Duijn CM
The hemochromatosis N144H mutation of SLC11A3 gene in patients with type
2 diabetes.
SO - Mol Genet Metab 2002 Mar;75(3):290-1
AU - Jungck M; Sauerbruch T
[Cost-effectiveness of screening in familial adenomatous polyposis]
SO - Dtsch Med Wochenschr 2002 May 3;127(18):980-1
AU - Grimwade D
Screening for core binding factor gene rearrangements in acute myeloid
SO - Leukemia 2002 May;16(5):964-9
AU - Rose PG; Shrigley R; Wiesner GL
Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a
case report.
SO - Gynecol Oncol 2000 May;77(2):319-20
AD - Division of Gynecologic Oncology, Center for Human Genetics, Department
of Genetics, University Hospitals of Cleveland, Western Reserve
University, Ohio 44106, USA.
OBJECTIVES: Fallopian tube carcinoma is similar to ovarian and
peritoneal carcinoma with respect to histology, response to
chemotherapy, and prognosis. BRCA germline mutations have been commonly
reported in ovarian and peritoneal carcinoma but rarely in other
gynecologic cancers. METHODS: A patient with fallopian tube carcinoma
and a family history of ovarian carcinoma underwent genetic counseling
and BRCA testing as did her daughter. RESULTS: The patient and her
daughter were found to have a germline BRCA2 mutation. CONCLUSION: Like
a family history of ovarian or peritoneal carcinoma, the occurrence of
fallopian tube cancer should alert the clinician to the possibility of
an abnormality in the breast cancer susceptibility 1 or 2 genes.
Copyright 2000 Academic Press.
AU - Cormier L; Valeri A; Azzouzi R; Fournier G; Cussenot O; Berthon P;
Guillemin F; Mangin P
Worry and attitude of men in at-risk families for prostate cancer about
genetic susceptibility and genetic testing.
SO - Prostate 2002 Jun 1;51(4):276-85
AD - Department of Urology, CHU Nancy-Brabois, Vandoeuvre-les-Nancy, France.
BACKGROUND: The aim of this study was to evaluate worry about genetic
susceptibility and the attitude of men with family history of prostate
cancer (CaP) toward genetic testing. METHODS: Three hundred seventy-five
eligible first-degree relatives (FDR) of men with CaP, were asked to
participate in a screening and to fill out a survey covering the worry
about genetic susceptibility and interest in genetic testing. RESULTS:
Of the 375 candidates contacted, 277 completed the survey, and had
undergone PSA measurement. Sixty-four percent worried a little or not at
all about inherited predisposition to CaP, while the remainder worried a
lot or extremely. The candidates who worried a lot or extremely were men
with high levels of durable anxiety disposition (STAI trait), who had
undergone a previous screening procedure and men with sons. Ninety-eight
percent of men expressed their interest in undergoing genetic testing.
The most motivated candidates to have the test done were men with
several relatives with CaP. CONCLUSIONS: The level of worry about
genetic susceptibility was low and there was a concrete interest in
genetic testing in FDR of men with CaP. This interest increased with the
number of CaP in the family. Copyright 2002 Wiley-Liss, Inc.
AU - Kotze MJ; Langenhoven E; Theart L; Marx MP; Oosthuizen CJ
Report on a molecular diagnostic service for familial
hypercholesterolemia in Afrikaners.
SO - Genet Couns 1994;5(1):15-21
AD - Department of Human Genetics, Faculty of Medicine, University of
Stellenbosch, Tygerberg, South Africa.
The development of DNA-based methods for the direct detection of
specific low density lipoprotein receptor (LDLR) gene mutations enabled
us to establish a molecular diagnostic service for familial
hypercholesterolemia (FH). This specialised service is of particular
relevance and can be applied in the Afrikaner population of South
Africa, where a founder gene effect increased the prevalence of FH to
about 5-10 times greater than that found in most other population
groups. Three point mutations in the LDLR gene were shown to account for
approximately 90% of all Afrikaner FH cases. We report on the results
obtained in 354 Afrikaner hyperlipidemics, from 274 unrelated families,
referred for mutation screening-during the four-year period following
the elucidation of the molecular basis of FH in this South African
population group. By screening for the three founder-related LDLR gene
mutations, approximately 50% of referrals were diagnosed as having FH.
Presymptomatic diagnosis of FH by DNA analysis overcame the difficulties
involved in the clinical diagnosis of some heterozygous cases. We could
offer appropriate genetic counselling to FH patients, in addition to
optimal clinical management by clinicians who referred the patients.
Genetic testing has made early diagnosis of FH, including prenatal
diagnosis, a reality.
AU - Berry DA; Iversen ES Jr; Gudbjartsson DF; Hiller EH; Garber JE; Peshkin
BN; Lerman C; Watson P; Lynch HT; Hilsenbeck SG; Rubinstein WS; Hughes
KS; Parmigiani G
BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and
prevalence of other breast cancer susceptibility genes.
SO - J Clin Oncol 2002 Jun 1;20(11):2701-12
AD - Department of Biostatistics, University of Texas M.D. Anderson Cancer
Center, Houston, TX 77030-4009, USA. email@example.com
PURPOSE: To compare genetic test results for deleterious mutations of
BRCA1 and BRCA2 with estimated probabilities of carrying such mutations;
to assess sensitivity of genetic testing; and to assess the relevance of
other susceptibility genes in familial breast and ovarian cancer.
PATIENTS AND METHODS: Data analyzed were from six high-risk genetic
counseling clinics and concern individuals from families for which at
least one member was tested for mutations at BRCA1 and BRCA2.
Predictions of genetic predisposition to breast and ovarian cancer for
301 individuals were made using BRCAPRO, a statistical model and
software using Mendelian genetics and Bayesian updating. Model
predictions were compared with the results of genetic testing. RESULTS:
Among the test individuals, 126 were Ashkenazi Jewish, three were male
subjects, 243 had breast cancer, 49 had ovarian cancer, 34 were
unaffected, and 139 tested positive for BRCA1 mutations and 29 for BRCA2
mutations. BRCAPRO performed well: for the 150 probands with the
smallest BRCAPRO carrier probabilities (average, 29.0%), the proportion
testing positive was 32.7%; for the 151 probands with the largest
carrier probabilities (average, 95.2%), 78.8% tested positive. Genetic
testing sensitivity was estimated to be at least 85%, with
false-negatives including mutations of susceptibility genes heretofore
unknown. CONCLUSION: BRCAPRO is an accurate counseling tool for
determining the probability of carrying mutations of BRCA1 and BRCA2.
Genetic testing for BRCA1 and BRCA2 is highly sensitive, missing an
estimated 15% of mutations. In the populations studied, breast cancer
susceptibility genes other than BRCA1 and BRCA2 either do not exist, are
rare, or are associated with low disease penetrance.
AU - Tlsty TD
Searching for targets: the power of somatic cell genetics.
SO - Genome Res 2001 Feb;11(2):187-8
AD - Department of Pathology, UCSF Comprehensive Cancer Center, University of
California at San Francisco, San Francisco, California 94143-0506, USA.
AU - Yesley MS
Protecting genetic difference.
SO - Berkeley Technol Law J 1998 Spring;13(2):653-65
AU - Florida. District Court of Appeal, First District
Pate v. Threlkel.
SO - Wests South Report 1994 Aug 1 (date of decision);640():183-6
AU - Florida. Supreme Court
Pate v. Threlkel.
SO - Wests South Report 1995 Jul 20 (date of decision);661():278-82
AU - Frontali M; Jacopini AG
Genetic counselling: evolution or involution?
SO - Community Genet 2000 May;3(4):175-8
AD - Instituto di Medicina Sperimentale CNR, Via Fosso del Cavaliere, I-00044
Frascati, Rome (Italy). firstname.lastname@example.com
The need for genetic counselling derives from the peculiarities of
genetic information, as compared to other biomedical tests, with
particular reference to (a) its predictive character; (b) the existing
gap between the ability to diagnose and to treat an inherited disorder,
and (c) the psychological, social and ethical problems that genetic
testing can raise. Counselling is traditionally performed by healthcare
professionals, specifically trained to help individuals to develop ways
of dealing with genetic information and gain a better understanding of
the problems related with it. The growing number of genetic tests (for
rare Mendelian as well as for common disorders), the development of
easier and cheaper molecular techniques, the increasing tendency of
physicians to have recourse to genetic tests, by-passing alternative
diagnostic procedures, are all factors that contribute to the vast
increase in the demand for genetic tests, a demand which is
significantly out of step with the available numbers of trained
counsellors. This paper discusses possible solutions, including the
institution of committees with regulatory powers on genetic testing, the
promotion of studies on models of genetic services, on programmes to
monitor the services currently offered by test providers, and the
expansion of training programmes and of employment opportunities for
genetic counsellors.
AU - Spinelli C; Puccini M; Bertocchini A; Lima M; Pacini F; Miccoli P
[Prophylactic total thyroidectomy in children and adolescents with
genetic mutations in the RET-protooncogene.]
SO - Pediatr Med Chir 2002 Jan-Feb;24(1):53-7
AD - Dipartimento di Chirurgica Generale, Universita di Pisa, Via Roma, 67,
Medullary thyroid cancer (C.M.T.) can be a sporadic form generally in
adults or a heredofamilial form where the first symptom appears in
pediatric and adolescent age. The hereditary form can be isolated or
associated with others endocrine neoplasias of type 2: MEN2a (with or
without cutaneous lichen amyloidosis) and MEN2b. The responsible gene of
the transmission has been identified in proto-oncogene RET localized on
chromosome 10. Point form mutations of this proto-oncogene have been
found on exons 10 and 11 in MEN2a and on 16 in MEN2b. In our study on 64
subjects, who belong 11 familiar groups, affected by MEN2a, MEN2b and
familiar C.M.T., underwent a genetic research to look for point form
mutations of proto-oncogene RET with PCR followed by the analysis of
restriction. A genetic mutation has been revealed in 25 subjects: 18
were already known affected by MEN2 and so surgical treated and 7 seemed
healthy (mean age 17.4 years, range 10-25). These 7 patients has been
undergone clinical research and surgical treatment: a total
thyroidectomy associated a lymphectomy of the central compartment. In
all cases the histological exam showed C.M.T. moreover a patient had
metastasis in lymph nodes of the central compartment. Another had
hyperparathyroidism and pheochromocytoma treated with total
thyroidectomy, parathyroidectomy and bilateral laparoscopic
adrenalectomy. The identification in a very early age of carrier
subjects of hill's gene inside an affected family, permits the execution
of a prophylactic total thyroidectomy to prevent the C.M.T.. The
penetrance of this neoplasia in hereditary form is 100%.
AU - Zhang B; Tan Z; Zhang C; Shi Y; Lin Z; Gu N; Feng G; He L
Polymorphisms of chromogranin B gene associated with schizophrenia in
Chinese Han population.
SO - Neurosci Lett 2002 May 3;323(3):229-33
AD - Bio-X Life Science Research Center, Shanghai Jiao Tong University,
Shanghai 200030, PR China.
Chromogranin is a widespread family of proteins in the neurosystem,
whose function is guiding the sorting and secretion of neuropeptides.
Using functional and positional evidences, chromogranin B was selected
as a candidate gene for schizophrenia. We systematically screened all
the promoter and exon regions of the gene and detected 15 single
nucleotide polymorphisms (SNPs), among which four SNPs (including two
non-synonymous SNPs) were selected for association analysis. In a cohort
of Chinese Han schizophrenia cases and controls, the results of both the
individual SNPs and the haplotypes of SNPs were significantly positive
(P<0.01). Our results confirm the role of neuropeptides in the
pathogenesis of schizophrenia.
AU - Cooper EB
Testing for genetic traits: the need for a new legal doctrine of
informed consent.
SO - MD Law Rev 1999;58(2):346-422
AU - Schutzer PJ
Genetics and ethics.
SO - Pharos Alpha Omega Alpha Honor Med Soc 1995 Winter;58(1):26-31
AU - Halperin M
Human genome mapping: a Jewish perspective.
SO - Assia Jew Med Ethics 1998 Sep;3(2):30-3
AU - Lagnado L
When racial sensitivities clash with research.
SO - Wall St J (East Ed) 1997 Jun 25;():B1, B5
AU - Jeffrey NA
A change in policy: genetic testing threatens to fundamentally alter the
whole notion of insurance.
SO - Wall St J (East Ed) 1999 Oct 18;():R15
AU - Coyne JC; Kruus L; Kagee A; Thompson R; Palmer S; Kruus L
Benign mental health consequences of screening for mutations of
SO - Am J Med Genet 2002 Feb 1;107(4):346-9
AU - Euhus DM; Smith KC; Robinson L; Stucky A; Olopade OI; Cummings S; Garber
JE; Chittenden A; Mills GB; Rieger P; Esserman L; Crawford B; Hughes KS;
Roche CA; Ganz PA; Seldon J; Fabian CJ; Klemp J; Tomlinson G
Pretest prediction of BRCA1 or BRCA2 mutation by risk counselors and the
computer model BRCAPRO.
SO - J Natl Cancer Inst 2002 Jun 5;94(11):844-51
AD - The University of Texas Southwestern Medical Center at Dallas,
75390-9155, USA. email@example.com
BACKGROUND: Because BRCA gene mutation testing is costly, occasionally
uninformative, and frequently associated with ethical and legal issues,
careful patient selection is required prior to testing. Estimation of
BRCA gene mutation probability is an important component of pretest
counseling, but the accuracy of these estimates is currently unknown. We
measured the performance of eight cancer risk counselors and of a
computer model, BRCAPRO, at identifying families likely to carry a BRCA
gene mutation. METHODS: Eight cancer risk counselors and the computer
model BRCAPRO estimated BRCA gene mutation probabilities for 148
pedigrees selected from an initial sample of 272 pedigrees. The final
sample was limited to pedigrees with a proband affected by breast or
ovarian cancer and BRCA1 and BRCA2 gene sequencing results unequivocally
reported as negative or positive for a deleterious mutation.
Sensitivity, specificity, negative predictive value, positive predictive
value, and areas under receiver operator characteristics (ROC) curves
were calculated for each risk counselor and for BRCAPRO. All statistical
tests were two sided. RESULTS: Using a greater-than-10% BRCA gene
mutation probability threshold, the median sensitivity for identifying
mutation carriers was 94% (range = 81% to 98%) for the eight risk
counselors and 92% (range = 91% to 92%) for BRCAPRO. Median specificity
at this threshold was 16% (range = 6% to 34%) for the risk counselors
and 32% (range = 30% to 34%) for BRCAPRO (P =.04). Median area under the
ROC curves was 0.671 for the risk counselors (range = 0.620 to 0.717)
and 0.712 (range = 0.706 to 0.720) for BRCAPRO (P =.04). There was a
slight, but not statistically significant, improvement in all counselor
performance measures when BRCAPRO-assigned gene mutation probability
information was included with the pedigrees. CONCLUSIONS: Sensitivity
for identifying BRCA gene mutation carriers is similar for experienced
risk counselors and the computer model BRCAPRO. Because the computer
model consistently demonstrated superior specificity, overall
discrimination between BRCA gene mutation carriers and BRCA gene
mutation noncarriers was slightly better for BRCAPRO.
AU - Pagon RA; Tarczy-Hornoch P; Baskin PK; Edwards JE; Covington ML;
Espeseth M; Beahler C; Bird TD; Popovich B; Nesbitt C; Dolan C; Marymee
K; Hanson NB; Neufeld-Kaiser W; Grohs GM; Kicklighter T; Abair C; Malmin
A; Barclay M; Palepu RD
GeneTests-GeneClinics: genetic testing information for a growing
SO - Hum Mutat 2002 May;19(5):501-9
AD - University of Washington, Seattle, Washington, USA.
The development and usage of two companion NIH-funded genetic testing
information databases, GeneTests (www.genetests.org) and GeneClinics
(www.geneclinics.org), now merged into one web site, reflect the
steadily increasing use of genetic testing and the expanding audience
for genetic testing information. Established in 1993 as Helix, a
genetics laboratory directory of approximately 110 listings, GeneTests
has grown into a database of over 900 tests for inherited diseases, a
directory of over 500 international laboratories, a directory of over
1,000 U.S. and international genetics clinics, and a resource for
educational/teaching materials and reports of summary genetic test data.
GeneClinics, founded in 1997 as an expert-authored, peer-reviewed,
disease-specific knowledge base relating genetic testing to patient
care, has grown steadily, now containing over 130 expert-authored,
peer-reviewed full-text entries relating genetic testing information to
diagnosis, management, and genetic counseling of specific inherited
diseases. In spring 2001 the two databases were merged and in October
2001 the two web sites were merged for the purpose of seamless
navigation into the GeneTests-GeneClinics site (www.genetests.org or
www.geneclinics.org); the GeneClinics knowledge base was renamed
"GeneReviews" to avoid confusion with the U.S. and international clinic
directories. As genetic testing has moved steadily out of research
venues and into routine medical practice, the user audience for these
databases has become international and expansive and includes healthcare
providers, patients, educators, policy makers, and the media. The use of
these combined resources has grown to approximately 3,200 visits/day.
Copyright 2002 Wiley-Liss, Inc.
AU - Oliveira C; Bordin MC; Grehan N; Huntsman D; Suriano G; Machado JC;
Kiviluoto T; Aaltonen L; Jackson CE; Seruca R; Caldas C
Screening E-cadherin in gastric cancer families reveals germline
mutations only in hereditary diffuse gastric cancer kindred.
SO - Hum Mutat 2002 May;19(5):510-7
AD - Cancer Genomics Program, Department of Oncology, University of
Cambridge, Hutchison/MRC Research Centre, Addenbrooke's Hospital,
Cambridge, UK.
The International Gastric Cancer Linkage Consortium (IGCLC) predicted
that up to 25% of families fulfilling the criteria for hereditary
diffuse gastric cancer (HDGC) would harbor CDH1 germline mutations. This
was based on observations from the low number of diffuse gastric cancer
families described at the time, and its validation would require
analysis of larger numbers. Here we report the results of germline CDH1
mutation screening in 39 kindred with familial aggregation of gastric
cancer, a subset of which fulfills the criteria defined by the IGCLC for
HDGC. CDH1 germline mutations were detected in four of 11 (36.4%) HDGC
families. No mutations were identified in 63.6% of HDGC families or in
kindred with familial aggregation of gastric cancer not fulfilling
criteria for HDGC. These results add support to the evidence that only
HDGC families harbor germline mutations in CDH1 and that genes other
than CDH1 remain to be identified. Copyright 2002 Wiley-Liss, Inc.
AU - Herzog JS; Jancis EM; Liao S; Somlo G; Weitzel JN
Restriction endonuclease fingerprinting enhanced conformation sensitive
gel electrophoresis (REF-CSGE) in the analysis of BRCA1 exon 11
mutations in a high-risk breast cancer cohort.
SO - Hum Mutat 2002 Jun;19(6):656-63
AD - Department of Clinical Cancer Genetics, Beckman Research Institute and
City of Hope (COH) Comprehensive Cancer Center, Duarte, California, USA.
Efficient genetic analysis of large exonic regions containing
heterozygous mutations and common polymorphisms can be difficult. We
have analyzed 30 patients for inherited susceptibility mutations (ISM)
within exon 11 of the BRCA1 gene as part of an ongoing genetic
epidemiological study of high-risk breast cancer (HRBC). A novel
combination of restriction endonuclease fingerprinting (REF) and
conformation sensitive gel electrophoresis (CSGE) was developed for
rapid and efficient screening of mutations. This method (REF-CSGE) was
compared side-by-side with standard CSGE and evaluated for both
efficiency and sensitivity of detection. REF-CSGE detected 100% of the
alterations found by CSGE. However, one variant was only detectable by
REF-CSGE. All samples with variant bands were sequenced to confirm the
nature of the alteration. In total, two small deletions (frameshifts)
and 62 point mutations (60 known polymorphisms and two variants of
unknown significance) were found in our cohort. The majority of the exon
11 polymorphisms detected are inherited as a linked haplotype. Point
mutations that comprise these haplotypes could be simultaneously
detected on a single gel by REF-CSGE, thereby decreasing the number of
sequencing reactions necessary to elucidate heteroduplex patterns seen
on CSGE gels. An analysis of the overall efficiency of both techniques
revealed that REF-CSGE required 67% fewer confirmatory sequencing
reactions, resulting in savings in both reagents and technician time.
Copyright 2002 Wiley-Liss, Inc.
AU - Gavert N; Yaron Y; Naiman T; Bercovich D; Rozen P; Shomrat R; Legum C;
Orr-Urtreger A
Molecular analysis of the APC gene in 71 Israeli families: 17 novel
SO - Hum Mutat 2002 Jun;19(6):664
AD - Department of Surgery B, Tel Aviv Sourasky Medical Center, Israel.
Familial adenomatous polyposis (FAP) is caused by germline mutations in
the APC gene. This study included 71 Israeli families referred for
molecular analysis of the APC gene. Analysis was performed by the
protein truncation test (PTT) of exon 15, and if negative, by direct
sequencing of exon 1 to 14. Mutations were found in 36 (50.7%) probands.
Mutation detection rates depended on the pattern of referral, such that
among the 40 probands referred from the Service for Hereditary Cancer
the mutation detection rate was 70%, whereas among the 31 probands
referred by other gastroenterologists detection rate was significantly
lower (25.8%). Of the 36 mutations detected, 21 were within exon 15, 13
within exons 1 to 14 and 2 were newly-described splicing mutations in
introns 9 and 14. A relatively high proportion of the mutations was
detected in exon 9 (6/36), five of them newly described. Altogether, we
describe here 17 new mutations. Within the two major ethnic groups in
Israel, patients of Ashkenazi and non-Ashkenazi origin, there was no
significant differences in the mutation detection rate or the
distribution of mutations within the APC gene. No founder mutation was
detected in any of these populations. Our data confirm that higher
detection rates may be expected in patients referred by clinical
services specializing in hereditary colon cancer. These results further
underscore the importance of complete analysis of all exons and
exon/intron boundaries, in order to achieve maximal detection rate in
patients suspected of FAP. Copyright 2002 Wiley-Liss, Inc.
The above citations and abstracts reflect those newly added to CANCERLIT for the month and topic listed in the title. The citations have been retrieved from CANCERLIT using a predefined search strategy of indexed subject terms. Although the search strategy has been refined as best as possible, citations may appear that are not directly related to the topic, and occasionally relevant references may be omitted.


text:
Sputnik Filament Table Lamp Polished NickelAn industrial salute to mid-century ingenuity, our iconic table lamp was inspired by last century's Space Race between the United States and Russia – and retrofitted with Edison-style filament bulbs developed even earlier. Its slim metal arms hold lights in orbit around a center sphere. Show product details... Dimensions
Sputnik Filament Table Lamp Polished Nickel - Overall: 21¼" diam., 32"H


text:
Maryland One-Stop Career Centers are located throughout Maryland to serve businesses and job seekers. Use the County directory below to find the Center nearest you.
Maryland One-Stop Career Centers provide a full range of assistance to job seekers (free of charge). The centers are staffed with qualified professional who can assist with training referrals, career counseling, job listings and other employment-related services.
Use our computers, phones, photocopiers, and fax machines to aid your job search!
Let your Maryland One-Stop Career Center help you find the job or the employee you want. Maryland One-Stop Career Centers are located in each of Maryland's counties and Baltimore City. Job seekers and businesses will find the Maryland One-Stop Career Career Centers leaders in using state-of-the-art technologies to match people with jobs and jobs with people. Simply click the county of your choice to find out more information about our services that help meet your employment needs.
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Questions or comments regarding the Division of Workforce Development and Adult Learning may be directed to firstname.lastname@example.com. Questions or comments regarding the DLLR website may be directed to email@example.com.
Updated December 4, 2012


text:
The historic Powerball jackpot boosted to $500 million on Tuesday was all part of a plan lottery officials put in place early this year to build jackpots faster, drive sales and generate more money for states that run the game.
Their plan appears to be working.
Powerball tickets doubled in price in January to $2, and while the number of tickets sold initially dropped, sales revenue has increased by about 35 percent over 2011.
Sales for Powerball reached a record $3.96 billion in fiscal 2012 and are expected to reach $5 billion this year, said Chuck Strutt, executive director of the Des Moines, Iowa-based Multi-State Lottery Association, the group that runs the Powerball game.
There has been no Powerball winner since Oct. 6, and the jackpot already has reached a record level for the game. It was first posted at $425 million but revised upward to $500 million when brisk sales increased the payout. It's the second highest jackpot in lottery history, behind only the $656 million Mega Millions prize in March.
It took nine weeks for the Mega Millions jackpot to get that high, before three winners — from Kansas, Illinois and Maryland — hit the right numbers, each collecting $218.6 million for their share of the split.
With soaring jackpots come soaring sales, and for the states playing the game, that means higher revenue.
"The purpose for the lottery is to generate revenue for the respective states and their beneficiary programs," said Norm Lingle, chairman of the Powerball Game Group. "High jackpots certainly help the lottery achieve those goals."
Of the $2 cost of a Powerball ticket, $1 goes to the prizes and the other dollar is kept by the state lottery organization, said Lingle, who also is executive director of the South Dakota Lottery. After administrative overhead is paid, the remaining amount goes to that state's beneficiary programs.
Some states designate specific expenditures such as education, while others deposit the money in their general fund to help supplement tax revenue. Continued...
The federal government keeps 25 percent of the jackpot for federal taxes.
Most states withhold between 5 percent and 7 percent. There's no withholding in states without a state income tax such as Delaware, Pennsylvania, South Dakota, and Texas. A New York City winner would pay more than 12 percent since the state takes 8.97 percent and the city keeps 3.6 percent.
Powerball and Mega Millions games are seeing jackpots grow faster and higher in part because the states that play both games agreed in 2010 to sell to one another.
Both games are now played in 42 states, Washington, D.C., and the Virgin Islands. The larger pool of players means jackpots roll over to higher numbers faster, which tends to increase the buzz about the jackpots which increases sales. It all can result in higher jackpots sooner.
"It really happened with both of these games became national games," said Terry Rich, CEO of the Iowa Lottery.
Still, just seven of the top 25 jackpots occurred after January 2010 when the cross-selling began. That just points to the unpredictability of games of chance like lotteries. It still comes down to the luck of the numbers, Rich said.
It has been proven that once the jackpot reaches a certain threshold more players buy.
Between $20 and $30 million in tickets were sold between Wednesday and Saturday drawings for most of October. Once the jackpot hit $100 million on Oct. 27, nearly $38 million worth of tickets were sold by Oct. 31. As the jackpot grew to more than $200 million on Nov. 17, sales surged by nearly $70 million by the next Wednesday. Then the jackpot reached over $300 million on Nov. 24 and ticket sales over the next four days surpassed $140 million.
"Somewhere around $100 million those occasional players seem to come back into the stores in droves," said Rich, the Iowa Lottery CEO. The lottery also notices a significant increase in workers and other groups joining together in pools to combine resources to buy numbers, he said.
Trina Small, manager at the convenience store in Bondurant, Iowa, where a couple bought a $202 million ticket on Sept. 26, said sales have been heavy. She said Monday night Powerball sales were at about $800, at least $200 more than normal. She expects Tuesday and Wednesday sales to be even more. Continued...
"It's kind of like Black Friday all over again," she said.
Small doesn't usually play the lottery herself but said she may buy a chance at the record jackpot. She's just trying to decide if her chances are better buying it elsewhere since a jackpot ticket was sold at her store just two months ago — the old adage about lightning striking twice.
"The odds are against you anyway but I'm pretty sure they're more against you getting one from this store," she joked.
Powerball has posted sales exceeding $714 million in the current jackpot run since early October and it's possible more than $1 billion in tickets will have been sold by the end of Wednesday when the next drawing is held.
A single winner choosing the cash option would take home more than $327 million before taxes.
Strutt said the chance of getting a winner this Wednesday is approaching 60 percent.
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Unity in the Foothills
102 Prospect Street, Torrington, Ct 06790
A Course in Miracles Tuesday evenings 7 p.m
Transformational Prayer Group Thursday 1:15 p.m. and Sunday 9 a.m.
First United Methodist Church
21 Fern Drive, Torrington, CT 06790
Rev. Barbara B. Shaffer, Pastor
860-489-8084 www.fumctorr.org
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Sunday Service at 9:30 a.m.
Sunday School from 10:45 a.m. to 11:45 a.m.
Pre-K thru Adult
Northfield Bible Church
10 Camp Hill Road, Northfield, CT 06778
860-283-9598 www.nccindependent.org
Bible Doctrines Class: Sunday at 9:00 a.m.
Sunday Service at 10:00 a.m.
Bible Study: Wednesday at 7:00 p.m.
Pot Luck Supper every 4th Friday of the Month at 6:15 p.m.
First Assembly of God
387 New Harwinton Road, Torrington, CT 06790
860-482-7464 www.firstagtorr.org
Sunday School for all ages 9:30 a.m.
Sunday Worship Service at 10:45 a.m.
Family Night Thursday at 7:00 p.m.
Adult Bible Study Prayer Service: Saturday at 9:15 a.m.
Cable 5 Sundays, Wednesdays, and Fridays at 3 p.m.
Founders Congregational Church
41 Birge Park Road, Harwinton, CT 06791
Sunday School and Services 10:00 a.m.
Bible Study: Tuesday at 7:00 p.m. and Thursday at 10:00 a.m.
Center Congregational Church
155 Main Street, Torrington, CT 06790
Email firstname.lastname@example.com
Sunday Services and Church School at 10:00 a.m.
Second Congregational Church of Winsted
Biblical, Traditional, Protestant Worship
800 Main Street, Winsted, CT 06098
Baptist and Congregational
Worship 10:00 a.m.
Sunday School 9:00 a.m.
July - August Worship 9:30 a.m.
Hours: 8:30 a.m. to 4:00 p.m. Monday - Thursday
8:30 a.m. to 12:00 p.m. Friday
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Wedding DJ / Party Favors Company Keene
We are a boutique New England entertainment company with concierge style service at the best prices in the region. Our services include DJ/MC, Up Lghting, Photo Booth, Candy Buffets, lighted Monograms and more! Call us at or visit us at today!
185 miles from Keene
Wait Staff / Party Favors Company
Our Servers are available for any event neat, professional, friendly, courteous and attentive to all your guest needs. From elegant to casual gatherings our servers are ready to serve. We help with set up and after event clean-up. Give us a call for…
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Add color and creativity to your special event by surprising your guests with a customized photobooth rental. Photobooth Companions are experienced, reliable, and most of all exciting! We service 15 states, 24/7 and never miss an event. All guests keep…
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Personalized custom bachelorette & bachelor koozies available here for all your party needs! Looking for custom printed koozies for your wedding? We've got all types of custom-printed party and wedding favors for every event! Low minimum orders and…
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Party Favors Company
If you are in need of a great time at your next event we can keep your party hopping with excitement of Wax Hands and other interesting "hands on" activities! FOR HIGH QUALITY SERVICE AND PRODUCTS OF WAX HANDS,PHOTO KEYCHAINS, MILITARY DOG…
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You have a party? Child's birthday, Anniversary, Baby shower, Wedding ceremony, a Corporate event or a SPESIAL DAY in your life? You want to make this event unforgettable and fun? We'll be glad to help you! Awesome Stilts walkers and Characters,Musicians…
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Children's Party Entertainment / Party Favors Company
Fun and professional face (and body) painting, natural henna tattoos , glitter tattoos, hair tinsel, hair feathers and more! Offered by experienced artist, Mayuri. I can create a perfect package plan for your party (including themed favors!) I'm also…


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Eastbourne Bandstand
Eastbourne is proud of its well preserved 1930's bandstand. Here you can enjoy a variety of concerts from Tribute Bands and 1812 Firework Concerts to Military Bands.
Eastbourne's first bandstand was built in 1893 and a Municipal Orchestra was formed in 1899.
There is a commemorative plaque at the rear of the current Bandstand in memory of Eastbourne bandsman John Wesley Woodward, who was one of those playing on the Titanic when it sank on April 15 1912.
The current Bandstand was built in 1935 and cost £28,000, engineered by Leslie Rosevere. It is one of the most distinctive sights in Eastbourne with its blue dome and silver finial. In recent years the Bandstand has featured in numerous television programmes such as Foyle's War, and is shown in the opening sequence of BBC South East News.
Seafront Office01323 410611
email a friend
Eastbourne BandstandGrand Parade, Eastbourne, BN21 3AD
Map reference: TV 615985 Lat: 50.76443 Long: 0.28947
The Bandstand is situated on the seafront opposite Devonshire Place. Pay and display parking on the seafront seven days a week. Eastbourne railway station is just 10 mins walk.
Parking : with charge
Accessible by Public Transport : 1 mile (1.6 kms) from Eastbourne station
Parking free after 6pm
Also at this venue
Eastbourne Bandstand
Bandstand as TV/Film Location
Events at this venue
Self-assessed accessibility details
- Designated parking for guests with disabilities
- The surface of the car park and pathway leading to entrance:
- is solid
- The route from the parking area to the entrance:
- Has a ramp
- Entrance is well lit
Public Areas
- Level access (no steps/thresholds) or access by ramp or lift:
- From the entrance to reception / ticket area
- To a specially adapted public toilet suitable for wheelchair users
- Good contrast between the floor and walls
- Contrast markings on clear surfaces such as glass doors
- Baby changing facilities
- Visitor information available in large print (14pt and over)
- Level access (no steps/thresholds) or access by ramp or lift to cafeteria
- Good contrast between the floor and walls
- Menus available in large print (14pt and over)
- Seating suitable for wheelchair users, ie moveable and good height for person sitting in a wheelchair
- Hearing loop system
- Seating available for visitors with limited mobility
- Clear signage
- Effective lighting for visually impaired visitors
- Good colour/tonal contrast for visually impaired visitors
- Routes/pathways suitable for wheelchair users or visitors with limited mobility
- Displays at suitable height for wheelchair users / children
- Audible alarm system
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Pain and Suffering
This is a one-shot in Jane's POV about her life before joining the Volturi. It is when Aro turns her as well and why she is always so mad.
I wanted to get my story of why I thought Jane was always so mean. I like Jane so I wanted to write this. Enjoy!
1. Witch Children
Rating 5/5 Word Count 873 Review this Chapter
"Run, my kids. Don't look back. These people are not nice. If you don't leave now you will be hurt." My mother said to us in a panicked voice.
"But mother, we won't leave you!" We screamed at her. She shook her head and tears fell out. She put a hand on each of our shoulders. I leaned my head on her hand.
"You don't have a choice. Run!" She said and then ran to open the door. She gave us pleading looks and then left. I heard loud voices and banging on the doors. The door gave way in the other room and we screamed. They yelled things like 'witches' and 'kill them'. I didn't fully understand. They were confusing. We were not witches. We did nothing wrong. We helped people. We were only different. We could hurt people that harmed anyone we loved. Maybe that's why. But that isn't evil or witch craft.
"Get those kids! They are the main problem!" A man yelled. He ran towards me and picked me up. Another man picked up my brother.
"Alec! What's going on?" I asked him in a feared voice. He looked scared. He looked helpless at the same time as well.
"I don't know Jane. I will do anything to save us though. Just wait and see." He said to me in a loving but scared voice. He was shaking now. The fear was pure now. I saw a man come up to him with a pan. He wouldn't harm my little brother if I had anything to do. I pushed my anger towards the man and he fell down to the ground in agony. Good, he would know what I felt like.
"So you want to cause pain do you? Well witch. How do you like it?" The man behind me said and then some men brought in my parents. They had gashes covering their body and were bleeding to death. They were crying for them to spare us, that they were the witches and not us but by now, I knew the truth. We were evil and they were going to kill us.
One of the men took a long knife out- not a sword, a knife- and slashed my mother's neck. She fell to a ground with a thump and the blood poured out. Tears welled up in my eyes and I bawled.
"How do you like the pain? This is what you have cursed upon the whole village!" The man yelled at me. I looked over at Alec. He was unconscious. They moved toward my father who was now whimpering over mother's dead body. He was covered in her blood. The knife was cleaned and drawn again. This time, instead of a fast slash they slowly glided it along my father's neck. How dare they! My anger overpowered my sorrow and the pain came out from under me. The man fell to the floor and writhed.
"Such a fascinating power." A man with red eyes exclaimed. He moved swiftly toward the men with such speed that it caused wind to be blown throughout the house.
The man hit all the men with such power that thunder rushed to my ears. They were all dead by the looks of it. Tears were pouring out of my eyes now. The man came over to me and I knew my life would be taken to day. The man saw the fear and chuckled lightly to lighten the mood.
"Don't worry. I won't hurt you. My name is Aro and I am here to help. You see, you have an interesting power that I would like and I would like to know if you would care to join my coven." He said. I was confused. What coven? That sounded rather mysterious.
"My apologies, I am a vampire. I am the leader of the Volturi. Would you like to join us?" He asked. I considered what he was offering. He was offering freedom and a family. He was offering a life. I nodded and looked at my brother with worried eyes. Aro noticed this and put a hand on my shoulder.
"I am interested in your brother's power as well." He said. I nodded and he nodded his acknowledgment and lifted my face.
"In order to change you, you will go through much pain. I will see you in three days. It will burn." He said and then lowered his mouth to my neck. He bit down and I felt the fire consume me. This was the opening to a new life and freedom and respect.
I would make whoever caused me pain, revenge. They killed my family so they would suffer. With much pain and suffering. I would not show weakness. I will not be nice!
See you soon, brother. I though and drifted into the pain.
- Author
- Kit_Kat_Cullen_XOXO
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juegos, vídeos y descargas de cartoon network. montones de juegos te esperan. pásalo en grande con las mejores series de dibujos animados de la televisión.
Title : Cartoon Network | Juegos Gratis, Vídeos y Descargas de los dibujos de TV
Description : juegos, vídeos y descargas de cartoon network. montones de juegos te esperan. pásalo en grande con las mejores series de dibujos animados de la televisión.
Keywords : ben 10, cartoon network, juegos, videos
Code Type : CSS Design / Table Design / Style Design
Title Caracter Number : The character amount for your site www.cartoonnetwork.es is 72 amount. This character amount is generally the most liked by search engines. As long as you follow all the rules you will have been able to sum up your sites content in the title section and you will have resulted successfully in search engines. We advise you to proceed in this way.
Meta Information : 39
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Alexa also cartoonnetwork.es
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Google Page Rank : 6
Google Indexed : Google Indexed None
The Pagerank system is the system where Google search engines give internet sites quality points or prevalence points. But the quality of an internet site is not necessarily determined by pagerank values. This is just one of the many criteria. The pagerank value of the site www.cartoonnetwork.es has been shown. To learn more about the Google PageRank point system, you can click on the heading of the article and you can read the What is PageRank article.
You can see the amount of pages search engines index of websites and what is shown in the search results from this section. For example the sum of pages that have been indexed by Google of the internet site www.cartoonnetwork.es on the date ''12.06.2011''(has to be variable) has been shown to be cartoonnetwork.
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Hi, I tried looking up spring roo forum for similar issue, 89627-ROO-test-doesnot-work-with-Oracle-DB. Ironically I m using roo 1.1.4 which is supposed to have this issue fixed. oracle 11g.
I added the following annotations to my java class for it to use sequence.
My sequence is defined in my schema and I m able to execute a select seq.nextval from dual using an external tool.
But with the app when I try to insert data, I run into sequence not found and it mentions hibernate_seq does not exist. I could not find references of hibernate_seq in all generated files.
I m not sure of how to make make insert statements use specific sequence than hibernate_seq.
Any help would be much appreciated.Code:@RooJavaBean @RooToString @RooEntity(identifierField = "pk_id", identifierColumn = "pk_id", table = "TABLE_NAME", schema = "SCHEMA_NAME") @SequenceGenerator(sequenceName="pk_id_seq",name="pkIdSeq")
thank you,


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The RAM-B-138-UN3 RAM Mount Marine Grade Aluminum Screw Down Plate Mount consists of the 1 inch diameter ball and socket system with RAM Universal Large Side Clamping Plastic Cradle.
Mount Base Design:The RAM-B-202 RAM Mount Marine Grade Aluminum Screw Down Plate has a 1.0 inch diameter Rubber Ball connected at right angles to a 2.5 inch diameter Plate. The plate has pre-drilled holes in the base plate, including the universal AMPS hole pattern. For a layout of the hole spacing and 1.0 inch rubber ball location, take a closer look with the RAM-B-202 Design Drawings (pdf file).
Mount Arm Design:The RAM Mount Dual Socket Arm (RAM-B-201) is a B Size 1 inch Ball Dual Socket Arm, made of Marine Grade Aluminum. The arm is 3 inches long between socket centers and is finished with a Black Powder Coating. The side of the arm includes a tightening knob which allows you to open and close the socket ends.
Mount Cradle Design:The RAM-HOL-UN3 Large RAM Plastic Side Clamping Cradle is designed to hold a large amount of different kinds of cell phones and electronic devices, including the Blackberry range of Phones Using the Cradle:This cradle has padded locking side clamps that close tightly on the item you want to hold. To release the clamp hold, simply press the button found at the bottom of the back of the cradle which will spring the clamps open. At the base of the cradle are two small support legs that move along the base edge of the cradle. The legs support the bottom of the item securely in the cradle, while allowing cable connection to the unit. This RAM universal side clamping cradle is designed to be used in a closed cabin, low vibration environment. This system is not recommended as a motorcycle mount. Universal Cradle Dimensions:


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ninearms wrote:Ah yes, the old smash the bar into your throat trick. I've done that a few times. Thanks to my massively muscular neck it's pretty much impossible to finish a session without at least scraping the skin of my Adam's apple just a little.
True, allthough this was a bit worse than usual. Still feeling it!
Anyway, friday I did a little benching, benched 112.5kg which had me beating kryptoboy . Back is pretty ok, but pobably not for lifting if I want to be on the safe side.


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Kevin Durant made one of his first eight shots, and the Oklahoma City Thunder were clinging to a two-point lead in the second quarter on Saturday against the Houston Rockets.
Then, Durant and the Thunder got going and finished the night with their best offensive performance on the road since 2009.
Russell Westbrook scored 28 points and Durant added 26 as the Thunder built a big lead in the second quarter and rolled to a 124-94 win over Houston. It was their largest road win since beating the Clippers 126-85 on April 15, 2009.
"I started off terrible and I just wanted to get going," Durant said. "I just wanted to come out and shoot a good shot, and I was able to get started."
Durant scored 11 points during a 16-0 run by the Thunder to end the first half and extend the lead to 18. Oklahoma City had another big run early in the third quarter to put the game further out of reach.
"The end of the second quarter is what pushed us over the top, and that third quarter was really good as well," Durant said. "We started off so well, got some steals, got some fast-break points. So it was a good one."
Former Thunder sixth man James Harden scored 25 for the Rockets, who went cold on offense for long stretches.
"(We were) careless with the ball," Harden said. "I don't know how to explain everything, but at least get a shot up and not turn the ball over."
It was Oklahoma City's second win this season over Houston, after taking the first meeting 120-98.
Kevin Martin, who came to Oklahoma City in the trade for Harden, finished with 19 points and five 3-pointers. Westbrook had eight rebounds and eight assists.


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- News
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Monday, 18 February 2013 08:52 The Economics Department at CIDE will host a workshop on Environmental and Development Economics in Latin America. The goal of the workshop is to stimulate research in environmental and natural resource economics that is relevant to economic development in Latin America. Although priority will be given to papers that have empirical content, theoretical papers with clear policy implications will also be considered.
The workshop will bring people together to share their work and exchange ideas Read more...
Monday, 11 February 2013 13:02 Job Read more...
Monday, 24 November 2008 01:05 Look at our last Training Course pictures!
CATIE, Costa Rica, August 2010
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Evaluating the Long-Term Effects of Global Climate Change on Brazilian Agriculture According to Farm Size
Authors: Juliana Speranza, José Feres
November, 2010
This paper aims to assess the long-term effects of global climate change on Brazilian agriculture. In particular, it will address the following questions: (i) What are the long-term effects of global climate change in terms of land values in the distinct Brazilian biomes?; and (ii) do these effects differ according to farm size? In order to answer these questions, the hedonic approach proposed by Mendelsohn et al. (1994) is estimated for Brazilian municipalities.
Microenterprises after the funding ends: Two Steps Forward and One Step Back
Author:Simone C. Bauch
July, 2010
Community-based natural resource management has become central to international conservation efforts in recent decades, as part of a pro-poor environmental agenda (Adams et al. 2004; Berkes 2007). The goal is to simultaneously improve local welfare and provide incentives for conservation through economic development based on sustainable use of natural resources. A key assumption is that the best way to accomplish this is by working with groups of households in communities, associations, or other types of networks.
Call for Proposals 2013 Round XVI |
Dates | Products |
Jan/25/13 |
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Preliminary 2 page proposal |
Abr/10/13 |
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Sep 22-27/13 | LACEEP's XVI Workshop (Cartagena, Colombia) |
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Smoothies. We all love them. The problem is they are expensive and not always 100% great for you. Why buy them when you can make them? If you need a quick snack, an instant pick me up or breakfast in … Continue reading
29 December, 2012
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15-Watt (50W) PAR30 Longneck Medium Base Soft White Outdoor LED Flood Light Bulb ENERGY STAR
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text: One of the last peaces of land in the zone with great potential! It has it all: Farming, lake, ocean and green view. Located on the highest points around with a first line to the lake o Laguna Garzon. You can also find all kinds of beautiful animals around. 100 Ha in one of the most exclusive places of Latin America.


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Botox Breast Lift May Worsen Frown Lines
While there are many doctors doing the Botox Breast Lift Procedure, it remains highly controversial and only moderately successful overall. I have performed this procedure with remarkable success in some, and less than exciting results in others. So let's step back a minute and look at how this procedure is designed to work – in order to do so we must review a little chest wall anatomy.
The pectoralis muscles work together to maintain the position of the breast. The larger pectoralis major muscle maintains the height of the breast tissue, while the smaller pectoralis minor muscle keeps the breast from undue motion pulling downward. The smaller the breasts, the easier it is for the muscles to maintain position and reduce excessive motion. After breast enhancement surgery , depending on whether the implant is silicone or saline filled, and whether it was placed over the pectoralis or under it, will make a huge difference in how the chest wall maintains breast position and whether Botox will be effective.
Since Botox (a toxin and medication produced by the bacterium Clostridium botulinum) injected into an area will cause a depolarization block and subsequent muscle paralysis- we can utilize this feature in many different ways. Everyone is familiar with cosmetic usage in the face to give a more younger appearance free of deep lines and wrinkles. We now use Botox to reshape eyebrows, turn frowns into pleasant smiles, stop unwanted and excessive sweating, and yes, even restore a more youthful breast appearance. Knowing the anatomy of the pectoralis muscles, and using simple pulley mechanics, we can inject the smaller muscle, the pectoralis minor muscle with Botox and it will relax. Then the stronger Pectoralis major muscle will have little resistance to the upward pull and can lift the breast skyward.
We have to use a significant amount of Botox, usually a full bottle which contains 100IU. We charge $1500 for this procedure, and the results last around 4 months. Since Botox is a strong toxin, and you have many vital areas on your body, it is important that the doctor doing the procedure is very familiar, and comfortable with the injection process. Many doctors feel it is too dangerous, and also might limit a person's ability to exercise which I have not found to be the case. Certainly, those patients who are very fit, with strong chest and arms do much better with the procedure than those who are less developed. Again, women with firmer, and smaller breast mass also seem to fare much better than those with large pendulous breasts. Remember, those who need a breast augmentation are not the target patient for this procedure. It isn't intended to make breasts look larger, or to rehab an augmentation gone bad. It is a body shaper, which lifts breasts and spirits, and can really seem to make those few unwanted pounds in the midsection seem to melt away.
Breasts and Breast Augmentation continues to be a major topic of discussion, the quest for the perfect shape is especially strong in the entertainment and modeling industry. It is a tough job being a plastic surgeon these days- for it is possible to get sued even when the results are fantastic!
Ex-Ms. Norway, now Maxim model, Kelly Hansen is suing her doctor to get him to pull down the before and after photos of her surgery. He said she would have to pay him to pull them down! She just paid him to" pull them up!" It's a wacky world.
Dr. Frye
Tags: Augmentation, Big, Boobs, Botox, Breast, cosmetic, Doctors, Dr. Darrin Frye, Dr. Frye, entertainment, exercise, Eyebrows, Firmer, Frown lines, Hollywood, Kelly Hansen, Lift, Maxim, Models, Ms. Norway, Pectoralis, Pedulous, Plastic Surgeon, Saline, Silicone, trollydolly.se, Trollydolly.us, weight loss, Women