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One week free trial
Free access via your institution
Single license for 20 EUR per year
prometheus is an internet-based service (www.prometheus-bildarchiv.de) for artistic and cultural research comprising a publicy accessible area as well as an access restricted, fee-based one. The service is presented by the Association of the same name in cooperation with the University of Cologne. prometheus charges users a license fee which is solely used to make the service available.
The prometheus image archive is a data broker which brings together heterogeneous and distributed image and media databases from a variety of sources. These databases are made available at no cost by public as well as private institutions for non-commercial research and teaching purposes.
User license fees are for administration costs incurred by the University of Cologne in running and expanding the service, and are not based on copyright fees associated with the images and media files themselves.
The services provided by prometheus including all associated elements, are intended exclusively for the stipulated purposes.
All offers, deliveries, electronic transmissions and the granting of rights to use, transpire solely subject to change, and not exclusively under the following terms and conditions for business and delivery.
All software, results, services such as modules, study materials, etc., made available by prometheus, are protected by copyright. Image and media data files (available in the prometheus image archive as well as in the other offers) may also be protected by copyright. The images of works of art may be protected by additional copyright. The clarification of all possible copyright protections is the responsibility of the user.
Users receive a non-transferable right to use the service for a limited time period in order to carry out scientific and research activities.
The user may not make any information or database search results available to third parties.
prometheus reserves the right to make any changes whatsoever, without notice, to the service. prometheus is not responsible for any changes that the databases made available in the archive make to their services.
prometheus does not guarantee the correctness, completeness or up-to-dateness of database material. This is the responsibility of the database owners.
The prometheus image archive is a service available on the internet via a server. It is accessible on the basis of single search requests on a read-only basis for non-commercial scientific, research and printing purposes. The systematic saving of large amounts of database material is not permitted.
The image archive can be accessed via Campus login or a personal account. Access via Campus login is possible for users belonging to a licensed institution. As this access is not personalized, there are only limited functionalities.
Users with personal accounts have the possibility to use advanced functionalities (e.g. collections and presentations).
prometheus archive images and media files are presented in a format optimal for monitors. They are intended only for research purposes and related presentations. Additional ways of utilization may be possible. They are specified for each image and each media file in the image archive under the heading "Rights" on a results page, if provided by the database supplier.
prometheus provides both public domain and copyright-protected images and media files. Users must adhere to all copyright laws as regards their further use of such images and media files.
Without permission from the copyright-holder copyright-protected images and media files available in prometheus are only intended for scientific and research purposes. They have to be deleted afterwards without further demand.
Written permission of the copyright-holder must be obtained prior to any publication of copyright-protected images and media files in print or other media. In individual cases, user rights can be obtained from the copyright-holder directly by clicking on the "Rights" button on the results page of the image archive.
Users may not photograph, photo-compose, or otherwise alter copyright-protected images and media files unless they have permission from the copyright-holder.
Users may not reproduce or electronically save copyright-protected images and media files for their own databases, or make images and media files available for third parties, unless they have permission from the copyright-holder.
Users must comply with German Press Guidelines including the prevailing copy and usage rights and the protective rights applicable to the use of images and media files. Users are solely responsible for any captions or text they add to an image or media file obtained from the archive. prometheus accepts no responsibility for legal breach of any kind arising from the unauthorized use of images and media files or the use of images and media files in new contexts. In case of any such legal breach, the user is the sole responsible party and shall be liable for any indirect, consequential, special, exemplary or incidental damages that might be claimed by third parties.
prometheus provides regular updates concerning changes to databases accessible through the service, including removal of existing databases and the availability of new databases.
Should non-adherence to the user's legal obligations result in any third-party claims, the user is obligated to indemnify prometheus and hold prometheus harmless from any such claims. Furthermore, the user shall be obligated to pay a fine to prometheus amounting to 400 percent the standard third-party user fee. In addition, prometheus also reserves the right to lodge a claim against the user, e.g. in case of damage to its reputation.
The user's license fee for a personal account for prometheus costs 20 EUR for one year.
The service is free for users who have a valid institutional membership of prometheus, or who are members of the prometheus Association.
There is no VAT on the user's license fee. prometheus as a non-profit project is exempt from VAT.
The user license fee can be paid directly via an online payment service. Optionally the user can obtain an e-mail invoice, which must be disbursed including administrative fee within thirty days of receipt. Decisive is the respective date of invoice.
The license fee is used solely to cover prometheus' operating costs. It is not connected to the site content, which is provided by the individual contributors free of charge.
License holders can only make claims against prometheus, if they are undisputed or legally confirmed. The license holders are not entitled to lien rights against prometheus.
Underaged users need the permission of their parents to purchase a single license.
User accounts are time-limited. It is incumbent on allocating institutions to arrange the validity period of user accounts.
Administrators must have a license with prometheus before they can distribute accounts. prometheus institutional user account holders may create personal prometheus accounts for staff and students of the institution. The institution is responsible for ensuring that they belong to the respective institution.
Personal account holders may not establish prometheus accounts for others.
Accounts are not transferable.
Technical defects will be rectified by prometheus within the normal time-frame for maintenance service, after a notification is received from the license holder. Liability regardless of negligence or fault as per § 536a BGB is excluded.
User fees will be adjusted in favour of the user in the case of major server disturbances, but not for minor server down-time or maintenance work. If a disturbance continues for a month or more, both users and prometheus can cancel their contractual obligations with immediate effect and without notice.
Irrespective of the legal cause of action, prometheus is liable for damages of no more than five times the user license fee, calculated on the amount of the fee in the year when the damage claim arises. Liability for loss of data is restricted to the typical time and effort needed which would have been required to secure daily backup copies of the data in question. The compensation limit does not apply in the case of deliberate acts or gross misconduct or if liability is assumed in the case of threat to life, bodily injury or injury to health or mandatory liability under product liability laws.
prometheus takes no responsibility for direct or indirect damage arising from any information or connection to information presented on the website including the web application.
prometheus takes no responsibility for the nature or content of any websites accessible via links from the website including the web application.
Having obtained a single license, the personal account is limited to one year after activation. After lapse of time the account will expire automatically and be extended after the next payment. There is no cancellation necessary.
prometheus has the right to cancel personal accounts without notice if users grossly fail to comply with the service's terms of use, in particular payment conditions or copyright requirements associated with images and media files obtained from the archive.
An important reason for users to cancel their account without notice arises if a disturbance in the service cannot be rectified within one month.
All cancellations must be in writing.
The place of the agreement and the place of jurisdiction for any claims arising from the agreement is Cologne, the location of the service provider.
Unless otherwise indicated German law applies and in particular, German copyright law.
Cologne, 05 August 2010


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Dooney & Bourke Horizontal Coffee Crossword Pouch for LG Optimus Chic E720$ 37 99 Retail Price: $49.99 Key Features:
Product Overview Compatibility Customer Reviews: Rating: 0 out of 5 Based on 0 Customer Reviews Be the First to Write a Review Product Overview Dooney & Bourke Horizontal Coffee Crossword Pouch for LG Optimus Chic E720 - Features built-in pockets to carry your license, cash, credit cards or other incidentals. Protect your mobile phone in style! Warranty Information PhoneSale.com stands behind the quality of our products with an Unconditional 100% Satisfaction Guarantee. All products are warranted for one year unless specified otherwise. For further warranty information, click here or contact us at 1-800-818-4575. Why Shop With Us? No Expensive Contracts All devices are sold without contracts and ready to use with your existing carrier. Personalized Expert Support Our customer service technicians know phones and are standing by to help with any questions you may have. Great Deals, Huge Selection Competitive pricing on the widest array of replacement, factory refurbished and new mobile devices. This product goes great with: Our Price: $ 13 99 Retail Price: $29.99 Our Price: $ 37 99 Retail Price: $49.99 | |
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Our luxury label Vero Moda Very consists of sophisticated daywear to fashionable eveningwear. It is a collection of elegant dresses, beautifully draped tops, tailored trousers and stylish jackets and blazers. Quality, fit, drapings and raw details exemplify the collection. The collection is heart-achingly on with a minimalistic feel.
See the VERO MODA Very universe here >
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This blog is an unofficial site created for fans to follow the Rice Owls, one of the nation's top-ranked baseball teams. Stop by to view pics, stories, interviews, and links to box scores and other things!
posted by my kid's sports pics at 9:41 PM
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This blog has been created to direct you to where you can find new postings of pictures when they are posted and available online. Come back and check often for new postings. Any questions? Email me at email@example.com and I will do what I can to answer them.
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Cocktail Name Winner "Major Award," from Stefan Was, of Cleveland, OH This was chosen from many, many wonderful names, by Paulius and Claudia, and I whole-heartedly embrace this great and elegant name, in its saying Cleveland without using Cleveland, its nuanced suggestion of Christmas and fun without saying either. Poetry! "Major Award" is a reference, of course, to one of my favorite movies, "A Christmas Story," which opens in Cleveland's Public Square. Donna and I never see a box with "Fragile" written on it without saying aloud, "Fra-GEE-lay." Darren McGavin's major award was of course, the famous leg lamp. Stop by Paulius's Velvet Tango Room, and you'll see the lamp in an upstairs window. Stefan, Paulius says come on in and you'll have a Major ...
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Why Union Scholars?
The mission of Union Scholars is to inspire academically gifted students to excellence in learning, spirituality and service. Union Scholars will discover the sources of major global issues and explore the resources of addressing them.
What is distinctive about Union Scholars?
Scholars become aware of the causes of global issues, and find ways to create solutions for those issues. Scholars not only learn about the past, but will use their knowledge to craft a better future.
What are the benefits of being a scholar?
* Reduced General Education Requirements. Compare requirements here.
* Smaller class size with courses exclusively for Scholars
* Unique courses that emphasize participation and creativity
* Interdisciplinary courses that address complex issues
* Individualized assistance with an original research project
* Coursework abroad built into the program.
* Textbook, Travel and Completion scholarships
What are the academic advantages of being a scholar?
Scholars program requirements are 6 semester hours less than the general education (LEAD) requirements. Additionally, Scholars find the course work to be more rewarding because they are interdisciplinary and discussion oriented.
Can I really afford to study abroad?
Yes, you can! Realizing that a world view is so important to a global understanding, one course taken abroad is built into the Union Scholars program with a travel scholarship.
How much are the scholarships?
Annual textbook scholarships are $250, a one time travel scholarship of $2,000 for an HONS course taken abroad, and a $1,000 scholarship for successful completion of a research project and all program requirements. Scholarships are awarded in the fall after a completed year in Union Scholars and continuation in the program. Completion scholarships are awarded upon graduation.
How do I qualify?
* High school GPA of 3.5 (or 3.33 college transfer GPA) and
* an ACT score of 24 or higher (or its equivalent)
* Apply and be accepted (enrollment is limited to space available)
Applications are reviewed and accepted at any time. Apply today!
For an in-depth study of the Union Scholars honor program, you may read the policy manual (PDF).
Questions? Ask us a question now!


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Personal Messaging temporarily unavailable.
Hi All,Just a short sharp message, have recently upgraded kde to 4.8.3 and am using kernel 2.6.38.In your honest opinion do I need to upgrade t'kernel to 3.6.18.Will this make any difference?Are the instructions easy enough for an noob to follow, What pitfalls are there?Thanks in advance,
Installing a different kernel After doing a full Reload-Mark All Changes-Apply with Synaptic, search Synaptic for the keyword kernel-. The kernel currently installed will have a solid box next to it. Select the newest/highest numbered kernel with the appropriate extension as per the scenarios described above that suits your machine best and Mark for installation and Apply. Please make sure that you have selected the kernel-x.x.xx.x-pclosx.xxx line and not the kernel-devel-x.x.xx.xx line. Once Synaptic has finished you need to reboot to use the new kernel. The first time you reboot after a new kernel, it will take longer time to do so because of the need to perform some jobs. Further reboots / startups will be normal. When you reboot after installing a new kernel, it becomes the default kernel. Older kernel is still installed and is available as a choice in the GRUB menu.
at the moment with the current options of kernel, i say noif your hardware is working well and you don't have problems with any driver it is not necessaryi am still using 22.214.171.124 on my desktop, i have some problems with power saving settings with 3.2.18 so i keep the older one loadedwhat you can't do is keep a kernel older than 2.6.38, older kernels won't let you use your system properly
I'm using kernel 3.2.18-pclos2.pae.bfs without any issues on my 3 years old laptop and my almost 5 years old desktop.But I've read that many forum members (like you guys) have problems and have decided to stay with 2.6.38So I guess, it's all about the hardware you have. It may be good to upgrade or it may be bad. You can't tell unless you try...


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hello September
Monday, September 3rd, 2012and Happy Monday everyone! August has passed by so fast, I can't quite believe it's over. For some, it's the end of summer, for some others spring is peeking in and yet for many others it's the unchanging everyday weather of sunny, humid and rainy days. In September, I'll share postings on simple things & DIY crafts that are easy but gratifying. Join me at my Facebook page.
and more lovely weaved twigs for inspiration.


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Hello all,
I have some plant root tissues that I would like to store at -80 for future RNA extractions. I was wondering if It was ok to store the tissue at -80, then quickly transfer it to a homogenization tube prior to extraction? This would probably unthaw the tissue somewhat. Would this pose a risk to my RNA?
Thanks in advance!
Storage of tissue at -80 followed by a breif unthaw prior to extraction
Started by tecvin, Apr 16 2012 07:35 AM
RNA extraction tissue
1 reply to this topic


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DumpsterDot is a network of privately owned and operated local roll off dumpster rental companies in Washington. We source competitive rental rate based on your Zip Code for remodeling projects or if you require a dumpster for household, yard or garage cleanups, you're at the right spot.
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Images of all sizes and shapes may not be available.
Additional Product Information:
Joy Carpets' Collegiate Mascot Rugs are perfect for the sports enthusiast that wants to decorate a room and show loyalty to a favorite university. Using state of the art, high resolution injection dyeing, these stunning rugs combine vibrant color with exceptional detail, certain to inspire the most demanding collegiate fans. Available in four sizes to complement any space, Joy Carpets' Collegiate Mascot Rugs will be a hit in the home and office alike.
Care and Cleaning:
Rugs Direct recommends you avoid using your vacuum's beater bar on any area rug. For complete information on area rug care and cleaning, please click here.
Note: The digital images we display have the most accurate color possible. However, due to differences in computer monitors, we cannot be responsible for variations in color between the actual product and your screen. Please be advised that in some cases patterns and colors may vary according to size. You may try this product risk-free for 30-days. If you decide not to keep it, you are responsible for return shipping charges.
To access or add to your Wish List you must first sign in to your account.
If you do not have an account and want to create one, please click the Register button. If you already have an account, click the Sign In button.
Or click Cancel to return to the previous screen. Nothing will be added to your Wish List.
To share information about this product with a friend, please fill out all of the information in this form and click the "SEND" button. All fields are required. Neither your nor your friend's e-mail addresses will be added to any database or list.
Best Seller: One of the most popular and best selling rugs we offer. | |
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Rugs Direct Delivery: In-home "white glove" delivery is available for selected rugs at additional cost. |


text: Dukus x Goes Like This x Music Video [Disclaimer: An MP3 Was Murdered in the Making of This song] By bnyce, In Dukus, Music Stream, Music Videos, New Music With no comments yet @DUKU5, you KILLED this bro! Big ups to my dude. Shout out Dead Bully. FREE Download Here: Read More Tags: amp3, an, annihalate, bully, dead, death, destroy, disclaimer, duke, duku5, dukus, eradicate, erradicate, goes, goes like, is, it, kill, like, like this, merc, merk, mp3, murc, murder, murdered, murk, music, Music video, shoot, shot, snuff, song, this, this is, video, was


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Lopez Island Family Resource Center Programs
Our programs reach a broad spectrum of island residents. Programs include:
Summer Workshop Registration!
Click here to Register for Lopez Summer Workshops. A credit/debit card is required. For more information visit Summer Workshops.
See what's happening…
The Back Page
Every Thursday we send a newsletter home with elementary students to let you know about things going on at the Resource Center and to give helpful parenting tips.
See: The Back Page
Your contribution will be used to help create healthy Lopez families and a healthy community.Newsletter
To receive news & information about our programs, sign up for our mailing list.LIFRC on Facebook


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Language Development in Newborns
Topic Overview
Speech and language lessons start in the uterus, where your unborn baby hears and responds to familiar voices. Indeed, soon after birth, your baby prefers and responds more to the mother's voice than to any other. Also, your newborn can recognize whether sounds are part of his or her native language.
Your newborn continues to learn language by listening to the basic and distinct sounds (phonemes), such as the "tr" and "cl" sounds in the English language. Your baby remembers sounds and continually learns more nuances of language, which are later expressed when he or she begins to talk.
Babies learn language skills through frequent interaction, such as reading and being talked to. Newborns respond to "baby talk," which is a higher-pitched, slower speech with emphasis placed on alternating words. Most parents instinctively speak this way to their newborn, gradually incorporating normal speech patterns and pitch.
You provide comforting contact when you read to your baby. Establishing a reading routine early helps make future reading comfortable and fun.
By: | Reference Healthwise Staff | Last Revised: Reference February 2, 2011 |
Medical Review: | Reference Susan C. Kim, MD - Pediatrics
Reference Thomas Emmett Francoeur, MD, MDCM, CSPQ, FRCPC - Pediatrics |
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Reference Terms of Use. Reference How this information was developed to help you make better health decisions.


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AutoMD Shifting the Power to You
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A lush foliage plant makes a lasting and natural gift, and always brings a smile to their day. Our local florists will select the best variety available in their region and set it in a decorative pot cover to deliver a grand presentation.
, we have connected these accounts. You can now sign into 1-800Flowers.com anytime using Facebook Connect.


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DOGS: AKC Born 5/13/13. 6 females, 2 red/white, 3 black/brindle/white, 1 black/white. Dew claws removed, will have vet checks, first shots, wormed, ID chip implanted. Raised in my home, parents on site. Ready mid July. View at seemydogs.blogspot.com. email sm... More info Email a friend |
DOGS: 3 choc, 1 Black available now. 3 males, 1 female. Declawed, shots. More info Email a friend |
DOGS: Idaho Chihuahua & Small Breed rescue could use your help to continue to save these rescues live! We pull from high kill shelters as well as owner surrenders as many as we can but need your help to be able to continue to do so! Majority of our rescues need... More info Email a friend |
DOGS: The best olde english bulldog puppy you can buy in my opinion. He is a super sweet and hansome boy who is 4 months, utd on vaccines, dewormed, crate trained and house broke. He does come with IOEBA papers. This boy has a unique color. He is available to... More info Email a friend |
DOGS: 10 beautiful white, cream-apricot, and apricot colored F1b goldendoodle puppies born on Mother's Day, 5/12/13. Beautiful pups from beautiful parents. The mother, Lucy, is a F1 Goldendoodle ½ Golden retriever and ½ Poodle. The Sire, Theo, is a full breed... More info Email a friend |
DOGS: 3 AKC English Mastiff Males remaining. Dew claws removed, will be well socialized and first set of vaccinations. Puppies will be ready for their new homes June 15th! Great home is a must!! Please contact me for more information. More info Email a friend |
DOGS: Chihuahua pups for sale, these pups can be AKC registered and will be small. Two black with brindle and white markings. They have had the 1st and 2nd shots. Delivery outside of Jerome available for small fee. Call 208-320-1481 or E-mail ahendsen1949@aol... More info Email a friend |
DOGS: I am expecting all 4 colors of double registered AKC and ASCA pups around the 4th of July. Put in your order for color and sex. I can email pics of parents and past pups. They are standard size. for more info call 208-550-2363 $650 More info Email a friend |
DOGS: We have the most adorable litter of AKC Shih Tzu Puppies available to loving homes. They will be ready to come live with you on July 7th. There are 3 puppies still available, 2 little and 1 little girl (adoption pending). The puppies will stay small, the... More info Email a friend |
DOGS: Pure bred puppies,champion lines, Dam on site, shots & deworming.Mother is AKC registered father is AKC but never got registered. So Puppies wont come with papers. Puppies DO come from Quality Blood lines. Mother is dark golden father is medium golden. ... More info Email a friend |


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Manage and edit your shots
Shot lots of great photos and videos? Here's how you view, organise, share, and edit them.
Photos hub
The photos you've taken or videos you've recorded with your phone are saved to the Photos hub, where you can browse and view them.
To find your photos and videos easily, mark your favourites, or organise them into albums.
View photos
Relive those important moments – view the photos on your phone.
Tap Photos .
To view a photo you've taken, tap Camera Roll and the photo.
To view the next photo, swipe left. To view the previous photo, swipe right.
Place two fingers on the screen, and slide your fingers together or apart.
To quickly zoom in or zoom back out, tap the photo twice.
Related information
Mark a photo as a favourite
Would you like to find your best shots quickly and easily? Mark them as favourites, and see them in the favourites view in the Photos hub.
Tap Photos > albums , and browse to the photo.
If the photo is in an online album, save it to your phone first. Tap > save to phone .
Tap > add to favourites .
To quickly mark several photos as favourites, select the album where the photos are, tap , select the photos, and tap .
You can also mark a photo as a favourite right after taking it. Just swipe right, and tap > add to favourites .
In the Photos hub, swipe to favourites .
Upload photos and videos to the web
Want to upload your photos and videos to a social networking service for your friends and family to see? You can do that directly from the Photos hub.
Tap Photos , and browse to a photo or video.
Tap > share... and the service.
Tap or .
To select several photos at once, in the Photos hub, tap the album and , select the photos, and tap .
To access your photos from all your devices, you can set up uploading to SkyDrive. SkyDrive is then available in the menu when you view your photos.
To set up the feature, on the start screen, swipe left, and tap Settings . Swipe to applications , tap photos+camera > SkyDrive , and select an option.
Change the background in the Photos hub
Have a superb shot that makes you feel good every time you look at it? Set it as the background of the Photos hub.
Tap Photos .
Tap > choose background .
Select the photo, and tap .
You can also set your phone to periodically change the photo automatically. Tap > shuffle background .
Create an album
To easily find photos of an occasion, a person, or a trip, organise your photos into albums according to subject, for example.
If your computer is a Mac, install the Windows Phone app from the Mac App Store.
Connect your phone to a compatible computer with a compatible USB cable.
On your computer, open a file manager, such as Windows Explorer or Finder, and browse to the folder for photos.
Add a new folder, give it a name, and add photos to the folder.
The folder appears as an album in the albums view on your phone.
If your computer's operating system is Windows 7 or Windows 8, you can also use the Windows Phone app. With Windows 7, you can download it from www.windowsphone.com/ .
When you delete an album from the phone, the photos in that album are also deleted. If you've copied the album to your computer, the album and the photos in it remain on your computer.
Tap Photos > albums . Tap and hold an album, and tap delete .
You cannot delete online albums from your phone.
Copy your photos to your computer
Have you taken photos with your phone that you'd like to copy to your computer? Use your computer's file manager to copy or move your photos.
If your computer is a Mac, install the Windows Phone app from the Mac App Store.
Connect your phone to a compatible computer with a compatible USB cable.
On your computer, open a file manager, such as Windows Explorer or Finder, and browse to your phone.
Open the folder for photos, and select and copy the photos to your computer.
If your computer's operating system is Windows 7 or Windows 8, you can also use the Windows Phone app. With Windows 7, you can download it from www.windowsphone.com/ .
Related information
Edit a photo
You can do quick edits, such as rotate and crop, to the photos you have taken. Or use auto-fix to let your phone fix your photo with just one simple tap.
Tap Photos > albums .
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Food package design in France
Food package design in France: I really liked the nice package design in France. We have a saying in Germany: "Das Auge ißt mit". Which means that the eye is eating as well. One is from Spain, can you find … Continue reading
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Tagged anchor, cheese, coca cola, food design, france, jean paul gaultier coke bottle, packaging, san sebastian, sardines, spain, sugar
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Just Released: Black Hardcore Bonus Scene 5 Starring D'Macho & Kingsley
For the first time Backroom members can log in and watch the Black Hardcore Bonus Scene 5 starring Hot House Exclusive Francesco D'Macho and Jason Kingsley! Don't miss this scene from our award winning Black -N- Blue series: 2007 GRABBY AWARD WINNER – Best Leather Video and 2007 GAYVN AWARD WINNER – Best Leather Video and Best All-Sex Video.
Francesco D'Macho has an appetite for man meat. Luckily Jason Kingsley is on hand to serve up his long, thick cock. D'Macho falls on his knees and slowly services top dog Kingsley. He moves from his cock to his ass and dives in, tongue first. Kingsley has worked up an appetite. He pushes D'Macho onto his back and rims his furry round ass, preparing it for his giant man-rammer. D'Macho jacks off while Kingsley power-fucks his hole. D'Macho takes over, pulling out a set of black power balls and shoving them one at a time into Kingsley's hole. Now that his hole is ready, D'Macho gives Kingsley what he really want… 10 inches of hot uncut cock! D'Macho shoots on Kingley's chest while Kingsley pounds his own meat until he drenches D'Macho's boot in tons of cum. Watch all the Hardcore Bonus action exclusively in the Backroom!


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We support higher education providers in enhancing the quality of the education they provide, through the sharing of good practice and ideas. This is done by means of a range of publications, research and events.
Each of our higher education reviews results in a report identifying good practice and making recommendations. We provide an overview of these findings, looking separately at the different contexts in which UK higher education is provided. The results of this analysis are published in our Outcomes papers and Information Bulletins, which are intended to be useful resources for quality managers and those who design academic programmes of study.
Two of our review methods - Institutional Review (England and Northern Ireland) and Enhancement-Led Institutional Review (Scotland) - involve the exploration of a particular theme, providing an opportunity to look in more detail at a specific aspect of the student experience. In Scotland this work informs the Enhancement Themes publications.
In addition, we are sometimes commissioned to conduct research into particular issues or aspects of UK higher education, the results of which we make available on this website.
Seeking to cultivate a climate of debate and collaboration that supports improvement, we also host events and publish discussion papers, such as the Talking about quality series, inviting feedback from all interested in the quality of UK higher education - from students and parents to policy makers and senior academics.
If you have expertise in higher education provision there may be ways that you can contribute to our work.
For information about the enhancement initiatives that we are undertaking from autumn 2012, please read our introductory leaflet (PDF 48.8KB).


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On our website you will find current workshop offerings, information for presenting a workshop via our office, resources, and information on room reservations. We invite you to make use of the information contained here as a fulfillment of Texas State's belief in supporting life-long learning for all employees. If you have any questions or feedback, please feel free to contact us.
The Office of Professional Development is a part of the Center for Professional Excellence, which also includes programming from Academic Development and Assessment; both Offices are in the Provost/Academic Affairs Division. Programming is also included from Instructional Technologies Support and Technology Resources in the Division of Information Technology.
The Professional Development Advisory Council encourages collaboration among the teaching, training and development entities on campus.
Texas State University is a charter member of the National Consortium for Continuous Improvement. Organized in 2000, over 90 members enjoy the opportunity to network and share best practices concerning common issues in higher education.
NCCI's mission is to function as a catalyst for higher education institutions to work collaboratively across institutions to employ effective methods for advancing academic and administrative excellences.


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String Quintets Nos. 3 and 4 Sandor Papp
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Even when the weather says otherwise, everything is blue skies with this solid coat! Puddle jumpers have met their match with this resilient rain-repelling jacket and the darling design will make dressing for a downpour fuss-free! It even has a special place of its own in the closet with a hand-painted wooden hanger! Pair with other Kidorable rain gear for a totally trendy look.
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Microsoft ending support for Office for Mac 2008
Microsoft announced today that it will end support for Office 2008 for Mac on April 9.
Office for OS X has been a staple in integrating OS X systems with many work environments that rely on Microsoft's popular office productivity suite. With its Mac Business Unit, Microsoft has maintained a dedicated development team for its Mac software which has spearheaded development of Office 2004, 2008, and the latest 2011 and 365 offerings.
With this development, those who use Office 2008 will still be able to do so, but will not be able to get any official support for the … Read more


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Star Signet Ring
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Oneliner | Open Content Licensing Non-Profit |
Summary | I worked for Creative Commons for approximately 3 years, initially as a Software Engineer, and then moved into a role as a community and business development manager to specifically push Open Source development surrounding Creative Commons licenses and standards. I worked directly worked with major technology companies around the world such as Google, Microsoft, Apple, Disney, Facebook, BBC, and so on. |
End Date | September 1, 2008 |
Location | San Francisco |
Website | http://creativecommons.org/ |
Status | Completed |
Next Step | Support CC! — Contact, if interested. |
Role | Manager |
Collaborators | Community |
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Jono's "Art of Community" Released Under CC BY-NC-SA 3.0 License
Jono contacted me to review his book about community management, The Art of Community, awhile ago. You should buy it and read it no less than 3 times. The chapters are well split, and provide great examples that make this a classic of the scale of my other favorite book about Open Source, Karl Fogel's Producing Open Source (How to Run a Successful Free Software Project). Jono's book is now freed to be translated, transmitted, reformatted as long as one doesn't make money off the work and does share back any changes since the book is now CC BY-NC-SA 3.0 licensed. Check it out!
Greg over at Creative Commons blog points out that: "The Art of Community isn't just written for current or would-be community managers. It outlines and discusses all of the issues that are pertinent to simply working with a dispersed community of contributors."
Honor the Jono by buying a copy! Honor the Jono and CC by translating the book and spreading the community love!


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Travel the scenic way in our taxi boats and save time as we take you from the shores of Montezuma to Jaco beach and back. Our boats depart daily from the center of Montezuma a 9:30am for the one-hour ride across to the mainland. Departures leave from Herradura beach, just north of Jaco, at 10:45am for the return trip to Montezuma at 12:00pm
Reservations and Contact Info:
Departure is at 10:45am - arriving in Montezuma by 12pm
Departure is at 09:30am - arriving in Herradura-Jaco beach by 10:30am
$45 per person / $10 per surfboard bag
Online Reservation Form: CLICK HERE TO RESERVE TAXI BOAT
Please confirm the name of your hotel in Jaco in order to send our driver for you.
BusBoat Uvita-Mal Pais / Santa Teresa $140.00
BusBoat Dominical-Montezuma $110.00
BusBoat Dominical-Mal País / Santa Teresa $120.00
BusBoat Manuel Antonio-Montezuma $80.00
BusBoat Manuel Antonio-Mal País / Sta. Ter. $90.00
BusBoat San Jose - Santa Teresa / Mal Pais $105.00
BusBoat San Jose Montezuma $85.00
BusBoat San Jose - Montezuma (4 hrs) $85.00
BusBoat Manuel Antonio - Montezuma (3 hrs) $80.00
BusBoat Jacó - Santa Teresa $60.00
BusBoat San José - Santa Teresa (4.5 hrs) $85.00
BusBoat Manuel Antonio - Santa Teresa (3.5 hrs) $90.00
Important: rates per person, we required a minimum of 2 passengers.
Online Reservation Form: CLICK HERE TO RESERVE TAXI BOAT
Taxi Boat to Jaco & Montezuma
The Taxi Boat: Only 1 hour boat ride!!!
(Saving you 6hrs of land and ferry trip)
General Info & Reservations
The operation is not possible from Jaco since this is a surfing spot and is not safe for you and our boats.
The departure time from Montezuma back to Jaco area is at 9:30 AM everyday. (Reservations in advance are required) We depart exactly from the beach in Montezuma, however the meeting point is at our front desk in Montezuma.
If this departure times does not suite your needs, you can always arrange a private boat for you and your party.
(Boat ride is around 1 hour)
Taxi Boat Information:
Taxi Boat Regular Service Departure Times:
09:30am from Montezuma to Jaco 10:45am from Jaco to MontezumaTaxi Boat Rates
The rate per person, per way is US$45
(two pieces of luggage are included on this rate, extra piece $15)
Free of charge for kids less than 4 years old.
Surfboard bags: $10 a piece.
* Please confirm pick locations and drop off locations
* There is a minimum of 2 passengers per combo reservation.
Have a Car Rental and want to take our Taxi Boat??
It is easy. We have an alliance with Budget Car Rental.
Return the vehicle in our office in Montezuma or in Herradura beach and you will have the same type of vehicle waiting for you at the other side.
(Please ask us for more details)
Reservations and Contact Info:
Fax – Costa Rica: 011(506) 2642-0891
eFax – New York: (646) 417-5171
eFax – Los Angeles: (213) 402-3893
Skype: traveltocr
I am concerned about safety, do you offer life jackets for all of your passengers?
Actually our boats are the only ones in the area full equipped with life jackets, operation permits and insurances.
Is the boat really \"rocky\"?
All depends on the ocean if the weather conditions are not good, we have to cancel the ocean operation and we help our clients to make the trip by land if necessary.
Would you recommend that passengers take medicine for motion sickness?
Is a speed boat you hardly get sea sick, the movement is back and forward not side by side.
Where do you put the luggage?
The luggage is covered with plastic bags and travel along the passengers.
Can I go and come from the same location the same day?
Only 1 daily departure available from each location for the regular taxi boat, however is you arranged a private boat just for your party you would be able to come back the same day. Other option is spending the night over then come back the following day.
I have a car rental can I leave it the Taxi Boat departure sport then pick up the following day when I return?
We always recommend to leave your car at your car rental office in Jaco, all car rentals in Costa Rica have a office in Jaco. This would be a safe place to leave your rental vehicle.
Operated by:
Loading Taxi Boat to Jaco from Montezuma beach
Taxi Boat Departure Sport in Herradura Beach Jaco (Click image to Enlarge)
Web Reviews about the Taxi Boat:
Taxi Boat to and from Jaco
The private speed boat, taxi boat or water taxi to Montezuma or Jaco is one of the best way of transportation in this area of Costa Rica. Saving up to 7 hours of hot and uncomfortable trip by land, the taxi boat most accurate way to get to Montezuma or Jaco.
Taxi Boat Jaco Montezuma
We ended up staying two nights here and then leaving via private taxi boat across the awesome Nicoya Gulf, ($30USD ea), for a 1 hour transfer to the to town of Jaco (which would have taken us at least 8 hours of busing / ferries to get to otherwise.
Taxi Boat
So in a few minutes we're off to taxi a "Taxi Boat" up the coast to Montezuma, which is on the peninsula on the north pacific side of Costa Rica. I've wanted to go to this area for a while now! See the image on how we'll cut across the ocean to get there. The boat is an hour instead of the many (treacherous) hours driving up the coast, and probably more scenic :)
Reservations and Contact Info:
Fax – Costa Rica: 011(506) 2642-0891
eFax – New York: (646) 417-5171
eFax – Los Angeles: (213) 402-3893
Skype: traveltocr
Tel: 011(506) 8849-8569 (Costa Rica)
Fax – Costa Rica: 011(506) 2642-0891
Fax – New York: (646) 417-5171
Fax – Los Angeles: (213) 402-3893
Skype: traveltocr
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Thermostatic Shower Panel with fixed head, hand held shower and 6 body jets.
• Hand shower. • Shower head - 8x8 inch. • 6 body jets. • With the most recent ceramic disk technology. • A shower service up to 100.4ºF (38ºC), thermostatically regulated for freedom and security, which can be raised if required by a button on the valve. • Head shower, hand shower and body jets can operate simultaneously.• Material: aluminum. • Finishing: aluminum & chromium. • Easily to install with standard connections on. the back of the panel.• All outlets are limited to: 2.5 gpm (9.5 l/min) max.• 10 Year Warranty• We provide directly to customers in 10 different countries, only online. • At your home within 3 - 5 working days!
Dimensions: Shower PanelHeight: 55.4"Width: 8.7"Depth: 19"Dimensions: Shower HeadDiameter: 8"


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This article was created in response to TV station trends to document the best hip hop trax of all time. Over the years I have watched several shows and I have felt that most of them have been way off the mark. I think a more accurate description should probably be hip hop and rap records that have sold the most units and made the most money for the major record companies. The aim of the article is not necessarily for me to tell you what the best hip hop trax are but merely to expose some of the hidden gems that hip hop as a culture has to offer and that are never likely to be represented on the corporate stations.
Low Profile "Pay ya Dues"
Taken from the 1989 album and only LP "We're in this together". Rapper WC later went on to form "WC and the Maad Circle" with Coolio before joining "Westside Connection" with Ice Cube and Mack 10. DJ Alladin went on to produce and work with rapper Ice T.
Third Bass "Brooklyn Queens"
Taken from the 1st of Third Bass's LPs entitled "The cactus album". Rappers MC Search and Pete Nice along with DJ Daddy Rich released 2 albums on Def Jam records Continue reading


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Invite a friend
Free Lectue: Dr. Melillo, Ground-Breaking Neurologist, Pioneer in Childhood Developmental Disorders
125 Kent Place Blvd, Summit, NJ | Get Directions »
Each year, well over one million children are diagnosed with autism, ADHD, Asperger's syndrome, dyslexia, OCD & other neurodevelopmental disorders. Dr. Robert Melillo brings a fundamentally new understanding of these conditions with his revolutionary Brain Balance program. It has achieved real, fully documented results for children, dramatically improving the quality of life - behaviorally, emotionally, academically, and socially − for them and their families.
Event Details
Where | 125 Kent Place Blvd, Summit, NJ (Summit High School) |
Next on | This event is over. |
Time | 7:00 pm–8:30 pm |
Who to bring | Moms, Dads, Families |
Website | http://www.brainbalancecenters.com/center/?location=summit-nj |
Phone | (908) 517-1101 |
email@example.com | |
Price | $0 |


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Friday, May 17, 2013
Monday, July 9, 2012
Wyoming Rodeo
While traveling in Wyoming I went to the Little Snake River Valley Annual Rodeo. I had a blast and got tons of really cool shots. I even got them published, three full pages in The Little Snake River Valley Tribune. See the rest of the photos here: www.nicholasjreid.com/collections/view/wyoming/
Dixon, WY 82323, USA
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Ladies Betty Boop Character Jacket
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Ladies DB Wool Coat
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Special Price: $49.99
Ladies Faux Fur Coat
ITEM: 8049 Look perfect from every angle in this soft and slimming jacket featuring lush ruffles cascading down the front and glamorous bell cuffs. Feels and looks like the real thing in flattering vibrant colors with removable belt. 100% polyester with elegant satin lining. Furrier hook closures. Imported. Dry clean. COLORS: Autumn Haze, Peacock. AVAILABLE SIZES:* MISSES' (S-2X)Learn MoreRegular Price: $179.99
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Ladies Faux Fur Ruffled Coat
ITEM: 8035 Our ultra plush masterpiece is so soft it feels just like sheared beaver. Its lushness is enhanced by flowing ruffles that give the coat an extra lightness and elegance, in gorgeous exotic patterns. Two on-seam pockets. Furrier hook closures. 100% polyester with soft poly-satin lining. Imported. Dry clean. COLORS: Bobcat, Cheetah, Jungle. AVAILABLE SIZES:* MISSES'(S-2X)Learn MoreRegular Price: $169.99
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Ladies Full Length Fashion Coat
ITEM: 7022 Long on looks and warmth, our luscious, soft-as-lambskin full-length coat is accented with acrylic faux fur shawl collar and cuffs. Front and back vertical stitching make for a slimming silhouette. Adjust the roll-up cuffs for a perfect fit. Decorative zigzag stitching enhances the two outside slash pockets. Quilted lining. Imported. Leather clean. COLORS: Oyster, Black. AVAILABLE SIZES:* PETITES' (S-XL) MISSES' (S-XL) WOMEN'S (2-3X)Learn MoreRegular Price: $319.99
Special Price: $219.99


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Watch free John Wayne movies and TV show westerns online. Here is another western full of boots, saddles, cowboy hats, leather, saddles, fast horses, wagons, stunts, superhero, action, chase scenes, stagecoaches, old west towns and beautiful landscapes. View this wonderful movie here on Westerns On The Web free. Enjoy watching hundreds of movies and TV shows free online with the biggest stars ever in Hollywood .
Watch John Wayne western movie free online.
The Lawless Frontier John Wayne Western
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Blue Note Presents The Italian JobVarious
CD (Item 603928) Blue Note (Italy), 2010 — Condition: New Copy
A rich range of sounds from the contemporary Italian scene – all artists who currently record for that country's branch of Blue Note Records – arguably one of the hippest branches of the labels in recent years! Italian Blue Note's been doing a great job of late – bringing together both older Italian players who finally get a shot at recording in a top-level setting, and younger players who really seem to bring a new energy to the label – using bits of classic modes, recast – in ways that give Blue Note a bit of energy from Schema, Deja Vu, and other labels in the Italian indie world! Titles include "Doctor K" by Flavio Boltro, "Kosmopolites" by Paolo Fresu, "In Cielo In Una Stanza" by Milestone, "Zoogami" by Fabrizio Bosso & Javier Girotto Latin Mood, "Follow The White Rabbit" by Funk Off, "You've Changed" by Fabrizio Bosso, "Moto Perpetuo" by Paolo Fresu Devil Quartet, "Epilogo" by Giuseppe Emmanuele, and "Five For Fun" by High Five. © 1996-2013, Dusty Groove, Inc. |
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Mother Ship (Japanese pressing): Jazz organ explodes to the next level – on this brilliant and rare session by Larry Young from 1969! The record was Young's last recording for Blue Note, and was never issued at the time – ... read more Jazz (CD) 15.99 |
With A Song In My Heart (Japanese pressing): A killer album that stands as a wonderful complement to Ike Quebec's classic LP sessions for Blue Note – and a set that's even more noteworthy for a rare early appearance of keyboardist Earl Van ... read more Jazz (CD) 15.99 | ||||
You Are Here I Am There: An early stunner from keyboardist Keith Tippett – served up with a punch and power that's missing from a lot of his later work! The music's a perfect blend of free-thinking jazz and some of the ... read more Jazz (CD) 15.99 |
Chapter Three: The coolest chapter so far in the long-lost story of the He3 Project – wonderfully spiritual jazz sounds from the San Francisco scene of the early 70s – recorded with a wicked blend of instrumentation ... read more Jazz (CD) 13.99 | ||||
Besides – Songs From The Sixties: Just a few of the songs here are from the 60s, and many of the rest are written by Gaetano Partipilo himself – and mixed with a few Brazilian numbers as well – all to round out a wonderfully ... read more Jazz (CD) 19.99 |
Don't Let Go (plus bonus tracks): A sweet bit of modern funk from George Duke – working here in a mode that's definitely tighter and more soul-based than his trippier albums of the early 70s – but also in a groove that's pretty ... read more Jazz (CD) 13.99 | ||||
Yuxtaposicion: Very very very cool stuff from Italy in the 70's. This tight little combo featuring Fender Rhodes, electric bass, and congas lays down some super tight grooves with a very deep, very funky, very laid ... read more Jazz (CD) 15.99 |


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10 Beyonce Magazine Covers We'll Never Forget
Beyoncé's February 2013 GQ cover has officially been unveiled, and it features the megastar in one of her most racy shots ever. The wife, mother, actress and platinum recording artist is proving that she still has it, but has it ever really left? We think not. Bey has been sexy, and we're out to prove it with "10 Beyonce Magazine Covers We'll Never Forget" Get familiar.
10. Harpers Baazar Nov. 2011
Beyonce went Willow Smith and whipped her hair for the November 2011 cover of Harper's Bazaar. Though she wasn't showing too much skin and barely gave any cleavage, Bey's face says it all in this shot with a mischievous parted lip smile. This cover is all the way Sasha Fierce. And did we mention she was pregnant in this shot?
9. Vogue April 2009
Who better to cover Vogue's "Shape Issue" than Bey? With a pulled back ponytail and just a peek of her shoulder, Jay-Z's lady gives sophisticated sexiness to this Vogue cover. Controversy surrounded the understatement of her curves in the photo, but Beyoncé looked hot nonetheless.
8. Ebony April 2009
Beyoncé's sexy knows knows no limits, and she proves it on the the April 2009 cover of Ebony. Donning a curly afro in all black, Bey is as strong as she is tempting in this shot. She proves that she can rock a plethora of looks, and ooze sex appeal.
7. W July 2011
What do you get when you put Beyoncé in a Louis Vuitton hat and a silk Givenchy bra with a sheer shirt on top? Major sex pot. Rightfully described as "Dressed to Kill," Mrs. Carter hits is with dead-serious sex appeal on this cover as she pops her collar with bedroom eyes. You can try an look away, but we bet it won't work.
6. Sports Illustrated Swimsuit Issue 2007
Following in the footsteps of Tyra Banks, Beyoncé became the second black woman to cover the Sports Illustrated "Swimsuit Issue" solo, and what a cover it was. Rocking a yellow and pink bikini, Bey showed off her body with a million dollar smile. Definitely a good way to make history.
5. DT February 2012
DT Spain had the three B's for theis February 2012 cover: Beyoncé, blonde and boobs. In a beige, ruffled accented bodysuit, Bey is as sexy as she is gutsy. This look was also featured in the singers much-talked-about "King B" promo shot last year. Pretty badass. we bet it won't work.
4. Dazed and Confused June 2011
If any of your Beyoncé fantasies included ice cream, they came to life on her June 2011 cover of Dazed and Confused. Barely showing any skin, Beyoncé serves face once again with blue eyeliner and her blonde coif as an ice cream cone drips down her hand. And there goes those parted lips again.
3. GQ Germany December 2008
This isn't the first time Beyoncé has sexed up the cover of GQ. The magazine's Germany edition got a taste of Bey for their December 2008 issue. The singer gave a whole new meaning to the phrase "drop top" as she barely held on to her clothing as it drapes her shoulders. She looked happy about it, and so were we.
2. Black Men April 2004
The cover of Black Men magazine has housed some of the sexiest women ever, and Beyoncé is on that list. Back in 2004, Bey graced the cover of the coveted men's magazine in a barely-there swimsuit. Showing off her curbs and washboard abs, "Booty-ful Beyoncé" served up a healthy serving of sexy for this shoot.
1. VIBE June 2007
We're gonna let you finish, but VIBE had one of the sexiest Beyoncé covers of all time! Our June 2007 issue featured King Bey drenched in water wearing a white top and leather shorts, posted against the wall. No need for a shameless plug there.


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- HuR promotes tumorigenic characteristics in hepatocellular carcinoma (2012)
- In the absence of apparent mutations, alteration of gene expression patterns represents the key mechanism by which normal cells evolve to cancer cells. Gene expression is tightly regulated by posttranscriptional processes. Within this context, RNA-binding proteins (RBPs) represent fundamental factors, since they control mechanisms, such as mRNA-stabilization, -translation and -degradation. Human antigen R (HuR) was among the first RBPs that have been directly associated to carcinogenesis. HuR modulates the stability and translation of mRNAs which encode proteins facilitating various 'hallmarks of cancer', namely proliferation, evasion of growth suppression, angiogenesis, cell death resistance, invasion and metastasis. Furthermore, it is well established that tumor-promoting inflammation contributes to tumorigenesis. In this process, monocytes are attracted to the site of the tumor and educated towards a tumor-promoting macrophage phenotype. While HuR has been extensively studied in various tumor cell types, little is known about HuR in hepatocellular carcinoma (HCC). Thus, the aim of my work was to characterize the contribution of HuR to the development of cancer characteristics in HCC. I was particularly interested to investigate if HuR facilitates tumor-promoting inflammation, since a role for HuR has not been described in this context. To this end, I depleted HuR in HepG2 cells (HuR k/d) and used a co-culture model of HepG2 tumor spheroids and infiltrating monocytes to study the impact of HuR on the tumor microenvironment. I could show that depletion of HuR resulted in the reduction of cell numbers. Additionally, the expression of proliferation marker KI-67 and proto-oncogene c-Myc was reduced, supporting a proliferative role of HuR. Furthermore, exposure to cytotoxic staurosporine elevated apoptosis in HuR k/d cells compared to control cells. Concomitantly, the expression of the anti-apoptotic mediator B-cell lymphoma protein-2 (Bcl-2) was markedly reduced in the HuR k/d cells, pointing to an involvement of HuR in cell survival processes. Accordingly, a pro-survival function of HuR was also observed in tumor spheroids, since HuR k/d spheroids exhibited a larger necrotic core region at earlier time points and showed elevated numbers of dead cells compared to control (Ctr.) spheroids. Interestingly, HuR k/d spheroids isplayed reduced numbers of infiltrated macrophages, suggesting that HuR contributes to a tumor-promoting, inflammatory microenvironment by recruiting monocytes/macrophages to the tumor site. Aiming at identifying HuR-regulated factors responsible for the recruitment of monocytes, I found reduced levels of the chemokine interleukin 8 (IL-8) in supernatants of HuR k/d spheroids, supporting a critical involvement of HuR in the chemoattraction of monocytes. Analyzing supernatants of co-cultures of macrophages and HuR k/d or Ctr. spheroids revealed additional differences in chemokine secretion patterns. Interestingly, protein levels of many chemokines were elevated in co-cultures of HuR k/d spheroids compared to control co-cultures. Albeit enhanced chemokine secretion was observed, less monocytes are recruited into HuR k/d spheroids, further underlining the necessity of HuR in cancer related monocyte/macrophage attraction and infiltration. Differences between chemokine profiles of mono- and co-cultured spheroids could be attributable to changes in spheroid-derived chemokines as a result of the crosstalk with the immune cells. Provided the chemokines originate from monocytes/macrophages, the different secretion patterns suggest that HuR contributes to the modulation of the functional phenotype of infiltrated macrophages, since the tumorenvironment is critically involved in the shaping of macrophage phenotypes. Regions of low-oxygen (hypoxia) represent another critical feature of tumors. Therefore, I next analyzed the impact of HuR on the hypoxic response. Loss of HuR attenuated hypoxia-inducible factor (HIF) 2α expression after exposure to hypoxia, while HIF-1α protein levels remained unaltered. Considering previous results of our group, showing that HIF-2α depletion (HIF-2α k/d) resulted in the enhanced expression of HIF-1α protein, I aimed to determine the involvement of HuR in the compensatory upregulation of HIF-1α protein in HIF-2α k/d cells. I could demonstrate that not only total HuR protein levels, but specifically cytoplasmic HuR was elevated in HIF-2α depleted cells pointing to enhanced HuR activity. Silencing HuR in HIF-2α deficient cells attenuated enhanced HIF-1α protein expression, thus confirming a direct role of HuR in the compensatory upregulation of HIF-1α. This as also reflected on HIF-1α target gene expression. I further investigated the mechanism underlying the compensatory HIF-1α expression in HIF-2α deficient cells. Analyzing HIF-1α mRNA expression, I excluded enhanced HIF1-α transcription and stability to account for elevated HIF-1α expression in HIF-2α k/d cells. HIF-1α promoter activity assays confirmed the mRNA data. Furthermore, HIF-1α protein half-life was not elevated in HIF-2α k/d cells compared to control cells, indicating that HIF-1α protein stability is not altered in HIF-2α k/d cells. Analysis of the association of HIF-1α with the translational machinery using polysomal fractionation finally revealed an increased istribution of HIF-1α mRNA in the heavier polysomal fractions in HIF-2α k/d cells compared to control cells. Since augmented ribosome occupancy is an indicator for more efficient translation, I propose enhanced HIF-1α translation as underlying principle of the compensatory increase in HIF-1α protein levels in HIF-2α k/d cells. In summary, my results demonstrate that HuR is critical for the development of cancer characteristics in HCC. Future work analyzing the impact of HuR on tumor-promoting inflammation, specifically macrophage attraction and activation could provide new trategies to inhibit macrophage-driven tumor progression. Furthermore, I provide evidence that HuR contributes to the hypoxic response by regulating the expression of HIF-1α and HIF-2α. Targeting single HIF-isoforms for tumor therapy should be carefully considered, because of their compensatory regulation when one α-subunit is depleted. Thus, therapeutic strategies targeting factors such as HuR that control both α-subunits and at the same time prevent compensation might be more promising.
- Atomic-Level Structure Characterization of an Ultrafast Folding Mini-Protein Denatured State (2012)
- Atomic-level analyses of non-native protein ensembles constitute an important aspect of protein folding studies to reach a more complete understanding of how proteins attain their native form exhibiting biological activity. Previously, formation of hydrophobic clusters in the 6 M urea-denatured state of an ultrafast folding mini-protein known as TC5b from both photo-CIDNP NOE transfer studies and FCS measurements was observed. Here, we elucidate the structural properties of this mini-protein denatured in 6 M urea performing 15N NMR relaxation studies together with a thorough NOE analysis. Even though our results demonstrate that no elements of secondary structure persist in the denatured state, the heterogeneous distribution of R2 rate constants together with observing pronounced heteronuclear NOEs along the peptide backbone reveals specific regions of urea-denatured TC5b exhibiting a high degree of structural rigidity more frequently observed for native proteins. The data are complemented with studies on two TC5b point mutants to verify the importance of hydrophobic interactions for fast folding. Our results corroborate earlier findings of a hydrophobic cluster present in urea-denatured TC5b comprising both native and non-native contacts underscoring their importance for ultra rapid folding. The data assist in finding ways of interpreting the effects of pre-existing native and/or non-native interactions on the ultrafast folding of proteins; a fact, which might have to be considered when defining the starting conditions for molecular dynamics simulation studies of protein folding.
- Conformational dynamics of the tetracycline-binding aptamer (2011)
- The conformational dynamics induced by ligand binding to the tetracycline-binding aptamer is monitored via stopped-flow fluorescence spectroscopy and time-correlated single photon counting experiments. The fluorescence of the ligand is sensitive to changes within the tertiary structure of the aptamer during and after the binding process. In addition to the wild-type aptamer, the mutants A9G, A13U and A50U are examined, where bases important for regulation are changed to inhibit the aptamer's function. Our results suggest a very fast two-step-mechanism for the binding of the ligand to the aptamer that can be interpreted as a binding step followed by a reorganization of the aptamer to accommodate the ligand. Binding to the two direct contact points A13 and A50 was found to occur in the first binding step. The exchange of the structurally important base A9 for guanine induces an enormous deceleration of the overall binding process, which is mainly rooted in an enhancement of the back reaction of the first binding step by several orders of magnitude. This indicates a significant loss of tertiary structure of the aptamer in the absence of the base A9, and underlines the importance of pre-organization on the overall binding process of the tetracycline-binding aptamer. Previous SectionNext Section
- Iodido(tri-tert-butylphosphane-κP)gold(I) (2012)
- The AuI atom of the title compound, [AuI(C12H27P)], shows an almost linear coordination, with a P—Au—I angle of 178.52 (3)° [Au—P = 2.2723 (14) Å and Au—I = 2.5626 (6) Å].
- trans-Dichloridobis(triphenylphosphane-κP)palladium(II) benzene hemisolvate (2012)
- The title complex, [PdCl2(C18H15P)2]·0.5C6H6, has the PdII ion in a square-planar coordination mode (r.m.s. deviation for Pd, P and Cl atoms = 0.024 Å) with the PPh3 and Cl ligands mutually trans. The benzene solvent molecule is located about a crystallographic inversion centre. The title complex is isostructural with trans-dichloridobis(triphenylphosphane)palladium(II) 1,4-dichlorobenzene sesquisolvate [Kitano et al. (1983 [triangle]). Acta Cryst. C39, 1015–1017].
- Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias (2004)
- Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis.
- Synthesis and Crystal Structure of 1-(3-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)thiourea (2011)
- The title thiourea was synthesized by reaction of 3,4,5-trimethoxybenzoyl isothiocyante with 3-fluoroaniline. The 3,4,5-trimethoxybenzoyl isothiocyante was produced in situ by reaction of 3,4,5-trimethoxybenzoyl chloride with ammonium thiocyanate in dry acetonitrile. The structure was confirmed by the spectroscopic, elemental analysis and single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/c with unit cell dimensions a = 13.0966(9), b = 16.6460(13), c = 7.8448(5), β = 106.721(5)°, V 1637.9(2) ų, Z = 4.
- Poly[[μ-ethane-1,2-diyl bis-(pyridine-3-carboxyl-ate)](μ-tetra-fluorido-borato)silver(I)] (2012)
- In the title compound, [Ag(BF4)(C14H12N2O4)]n, the coordination of the Ag+ ion is trigonal–bipyramidal with the N atoms of two ethane-1,2-diyl bis(pyridine-3-carboxylate) ligands in the apical positions and three F atoms belonging to different tetrafluoridoborate anions in the equatorial plane. The material consists of infinite chains of [Ag(C14H12N2O4)] units running along [001], held together by BF4 − bridging anions.
- (1R,2S)-Methyl 1-(4-chloro-phen-yl)-3-oxo-1,2,3,4-tetra-hydro-cyclo-penta-[b]indole-2-carboxyl-ate 0.2-hydrate (2011)
- The title compound, C(19)H(14)ClNO(3)·0.2H(2)O, crystallizes with five mol-ecules and a disordered water mol-ecule in the asymmetric unit. Four of the five mol-ecules form hydrogen-bonded dimers via N-H⋯O hydrogen bonds towards another symmetry-independent mol-ecule, whereas the fifth mol-ecule forms a hydrogen-bonded dimer with its symmetry equivalent, also via N-H⋯O hydrogen bonds. The dihedral angle between the planes of the fused benzene ring and the five-membered ring to which it is attached is 79.45 (13), 49.00 (15), 72.49 (16), 81.91 (18) and 76.38 (16)° for the five mol-ecules in the asymmetric unit.
- 3-Allyl-6-bromo-1H-imidazo[4,5-b]pyridin-2(3H)-one (2011)
- In the title compound, C15H14N2O4, (I), the molecule lies on a twofold rotation axis which passes through the central C atom of the aliphatic chain, giving one half-molecule per asymmetric unit. The structure is a monoclinic polymorph of the triclinic structure previously reported [Brito, Vallejos, Bolte & López-Rodríguez (2010). Acta Cryst. E66, o792], (II). The most obvious difference between them is the O/C/C/C—O/C/C/C torsion angle [58.2 (7)° in (I) and 173.4 (3)/70.2 (3)° in (II) for GG and TG conformations, respectively]. Another important difference is observed in the dihedral angle between the planes of the aromatic rings [86.49 (7)° for (I) and 76.4 (3)° for (II)]. The crystal structure features a weak π–π interaction [centroid–centroid distance = 4.1397 (10)Å]; this latter kind of interaction is not evident in the triclinic polymorph.


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the grim recycler
random work doodle
Over the few months I've been doodling these game characters in my spare time.
I got a lot of requests for prints so I've put them up for sale as a...
SPACE! The Gallery Show
(curated by the super popular bro, MIKE MITCHELL)
June 21st 7 – 10pm
@Gallery 1988 (west) in Los Angeles
Scott C.'s contribution to this Friday's Space art show, curated by Mike Mitchell, at G1988 (WEST). This show is gonna be a good one. Arrive early....
My thoughts on Man of Steel.
" :) "
One of four prints I'll have at SPACE! The Gallery Show this Friday at Gallery 1988: WEST. Be there or be somewhere significantly less...
Above & Below
Meanwhile… this was happening out West
Double rainbow over the Chicago Skyline - June 17, 2013
Rainbow over the John Hancock Building.


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Pastels Gone Wild: Lovisa Ekholm for Grazia Germany
Ah, we just can't get enough pastels right now and this editorial for Grazia Germany pretty much sums up everything about spring. Icy blue thaws into blushing pink with dashes of sunshine yellow and spring green. Ruffly layers and feminine chiffon create a decorative feel spiked with sharp-edged accessories and a nonchalant rocker-girl bouffant. Tina Luther photographs.


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march' 05 forbidden/limited card list - Yu-Gi-Oh! Ultimate Masters: World Championship Tournament 2006 Questions for Gameboy Advance
More: Gameboy Advance Yu-Gi-Oh! Ultimate Masters: World Championship Tournament 2006 Questions
march' 05 forbidden/limited card list
Hello everyone! I've been looking everywhere for a way to get march' 05 forbidden and limited card list but can't find it!!!! I need it to unlock the "Refer to the March '05 forbidden and limited card list". So, how do you get that forbidden list anyway!? And if you happen to have a cheat for it then it's very welcome too.
<BR>Thanks to all in advance.
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As Superintendent of Catholic Schools he will be responsible for eight schools in the diocese with an enrollment that exceeds 2,500 students and employs 190 teachers and 106 support staff. Four Catholic schools are in Avoyelles Parish: St. Anthony in Bunkie, St. Joseph in Plaucheville, St. Mary in Cottonport and Sacred Heart in Moreauville.
Roque earned a B.S. in English/Social Science from Southern University in Baton Rouge and a M.Ed. in School Administration and +30 in Education Leadership from Northwestern State University in Natchitoches. In 1995 he began work on a doctorate in Development Education/Student Development and Personnel with an emphasis on Higher Education Administration at Grambling State University.
Roque served as assistant superintendent of Administration for the Rapides Parish School Board from 1997 until 2010. In this capacity his duties included administrative oversight for budget preparation, central purchasing, compliance with state and federal statutes, and construction management. He researched and implemented many projects which include areas of technology, risk assessment and management.
He served in various capacities at the Louisiana Math, Science and Arts School in Natchitoches, including associate director of Admissions and Recruiting and director of Internal Affairs. He is also a former teacher and principal.
Roque is a member of St. Augustine Catholic Church, Isle Brevelle, LA., where he has served as director of Religious Education for the past 30 years, currently serves as president of the Pastoral Council and is a member of the choir. He is a past Grand Knight of the Knights of Peter Claver, Council 100, and an associate member of the Congregation of Divine Providence.
Currently he is a member of the Natchitoches Parish Library Board and the Rapides Parish Children and Youth Planning Board. He is a former member and past president of the Rotary Club, served on the Rapides Parish Children Advocacy Board (CASA), and the United Way Board of Directors.


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Celebrate life-long learning
The activities taking place this Education Week give us the chance to celebrate something that is often taken for granted - the rich and diverse learning environment that is offered to Yukon students all year round. This is a great time to thank our teaching professionals, families, First Nations, schools, school councils and communities for their contributions and support.
As a product of the territory's education system myself, I have fond memories of the opportunities I was afforded in Yukon schools, including outdoor education and student exchanges. Experiential hands-on learning options have grown and diversified through the years and, together with a strong classroom environment, they give students a well-rounded education that helps them build successful, exciting careers and lives.
Partnerships have allowed us to provide more for students than might otherwise have been possible. A number of initiatives have been accomplished through working together with Yukon First Nations governments and people. These include language programs (in 21 Yukon schools, for seven of eight Yukon First Nation language groups) and the Champagne and Aishihik First Nations Southern Tutchone Bi-Cultural Program, which increases Southern Tutchone content for Kindergarten to Grade 2 students at St. Elias Community School.
We also signed an MOU with the Council of Yukon First Nations and Canada to create a joint Education Action Plan to promote the success of First Nation learners. And, a recent development is that Yukon First Nations social studies will become a requirement for all Grade 5 classes, beginning next fall. Yukon's Education Act supports the incorporation of up to 20 per cent locally-developed courses and states every school shall include activities relevant to Yukon First Nation culture, heritage, traditions and practices.
This year's Education Week theme is Every Student Every Day, chosen as a reminder of the importance of lifelong learning. A thirst for knowledge is an element of a satisfying life and so we work to support everyone in pursuing their goals and interests. For example, Yukon Education was pleased to launch a new website yesterday (http://yukonworkfutures.gov.yk.ca/), which will help Yukoners research careers and look for jobs. It provides a guide to career opportunities based on current and projected economic needs, profiles the most in-demand occupations in Yukon and offers details about necessary training.
Government, educators, parents and students always have an interest in improving student success and enhancing the education system we have built together. With that in mind, the Yukon Legislative Assembly recently passed amendments to the Education Act, which will ensure that students have access to more instructional time and teachers receive more professional development opportunities.
As a final note, I would remind Yukoners of our partnership with Victoria Gold Yukon Student Encouragement Society on the Every Student, Every Day initiative to improve student attendance in Yukon schools. The first projects to receive funds will be announced at a reception at MacBride Museum this evening, from 5:30 to 7:30 p.m.
I encourage all members of the public to attend the reception to help us celebrate, and to join us at some of the approximately 40 different Education Week activities scheduled throughout Yukon this week, hosted by many organizations with an interest in education including schools, Yukon College, First Nations, the Commission Scolaire Francophone du Yukon and non-government organizations.
Scott Kent
Minister of Education


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Strike King Tour Grade Painted Blade Spinnerbait - $5.19
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Comments: Great spinnerbait. It is on of my favorites. Just bought a new one in the chart sexy 3/8. Took it out for the first time and caught a 3-13 and 4-14. It was 99 out with out the heat index today in central Illinios and this was the only thing that would catch them.
From: Joseph: IL
Comments: Quality Lure! The skirt will get tangled in the blades now and then but, apply a little Atlas-Mikes scent to the skirt and it "dramatically" reduces the tangles. I found it to get me stronger strikes too. If you don't use scent, another way to avoid tangles is to make smooth casts. No flicking, jerking, or whipping on the cast. This lure is painted with good paint, more like a powder coat. I haven't had any issues with the paint coming off at all. I suppose it would if you fish a lot of rocks but, then again that's with all lures in the rocks. I've caught a ton of fish with this lure. Overall, "very quality lure"
Comments: GREAT spinnerbait bill does not know what he is talking about i bought one from a local tackle shop with a willow and colarado in sexy shad and then went fishing with my dad at the coal mines and caugth a 6 1/2 pound bass !!!!!! BILL IS SO STUPID FOR SAYING THAT!!!!
From: Nathan: USA
Comments: Cheaply made and over-advertised. You would be well advised to buy another brand. Paint came off the blades immediately. Skirts tangle in the blades and swivels. Skirts stick together like glue after one use. They're just cheap and over-priced. Hyped by an ARMY of professional anglers.
From: Bill: Owasso, OK
Comments: love this lure got 3 of them for christmas all in 1 oz. and i love them but they are larger than most spinnerbaits but still very good though
From: Nathan: Bremen, KY
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