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Okay one thing I've found is that I think that one person to make a difference for isn't enough and then try to make a difference for so many and that's the only way it counts in The Gift 30 Day Challenge. So what I am going to commit to is making a difference for 1 person a day. And if there are others I'll do it. I've been trying to make this a numbers game and it is NOT a numbers game. That's exciting. I'll let the Universe figure out all the great ways to bring my intended goal of a min of $50K plus expenses by July 28th.
I connected deeply with my wife's cousin over the 4th. And offered to trim the hedges that have not been clipped in years because of her late husbands illness. I did it. She was so appreciative and happy I did it. I also offered to give her suggestions about NOT spending money on new siding and just getting the house painted. I used to paint houses in college and knew enough to make a difference. So felt like I totally made a difference with her in a way I knew how to. We stayed and ate at her house for free nearly a week and took us on a tour of Annapolis. I know that may sound corny but that was the deal anyway. I happy we were staying at her house cause she invited us but my contribution as to bring value to her from our stay. It was fun.
I was looking for the synchronicity of me doing that but realized that staying with her at no cost was huge for me and my family. We hardly spent any money on vacation!!!
The author of this post asked to remain anonymous while documenting their 30 Day Challenge. I have agreed to serve as editor to ensure anonymity. – Kristen


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A collection of news and information related to Liberal Democrats (UK) published by this site and its partners.
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British leader David Cameron faces dissent on EU membership
LONDON — Prime Minister David Cameron moved Monday to beat back a brewing rebellion within his Conservative Party over Britain's membership in the European Union, rejecting demands for a speedy public vote on exiting the trading bloc but insisting...Tags: Trade Agreements, David Cameron, Lobbying, National Government, Conservative Party (UK)
Prime Minister Cameron argues to keep Britain's nuclear arsenal
LONDON – Amid international alarm over saber-rattling by North Korea, British Prime Minister David Cameron made an impassioned defense Thursday for maintaining his country's independent nuclear deterrent, despite growing domestic complaints of...Tags: North Korea, David Cameron, National Government, Kim Jong Un, Nuclear Policy
British Parliament approves gay marriage despite Conservative foes
LONDON -- British lawmakers voted Tuesday to allow gay and lesbian couples to wed, siding with majority opinion in the country but exposing major divisions within the ruling Conservative Party. Nearly seven hours of debate in Parliament culminated in...Tags: Gay Rights, Family, Marriage, David Cameron, Social Issues
Tokyo governor resigns to form new party, run for parliament
World NowShintaro Ishihara, the strident governor of Tokyo who helped touch off a major dispute between China and Japan over some uninhabited islets near Taiwan, announced that he was quitting his post and forming a new political party.... -
Britain's Liberal Democrats give up on reforming House of Lords
World NowNick Clegg, Britain's deputy prime minister, conceded defeat Monday in the campaign to overhaul the House of Lords by turning the venerable but undemocratic institution into a partially elected one. He acknowledged that his Liberal Democrats... -
Plastic pellets blanket Hong Kong beaches after typhoon
World NowTons of tiny plastic pellets are washing up on Hong Kong beaches after a powerful typhoon sent "white plastic sacks of death" tumbling off a ship into the sea, environmental activists say, warning the spilled pellets could send chemicals up... -
London's colorful mayor wins a second term
World NowBoris Johnson, the floppy-haired, often hilarious mayor of London, wins a second term. Johnson, a Conservative, beats Labor Party candidate Ken Livingstone, the man who was mayor of the British capital before him.... -
May 13, 2013
|Story| Los Angeles Times
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| Los Angeles Times
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May 6, 2011
|Story| Los Angeles Times
May 7, 2011
|Story| Los Angeles Times
Original site for Liberal Democrats (UK) topic gallery.


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Easement Vacation and Replats
The Survey Section is the initial point of contact for applying to vacate an easement managed by the Department of Natural Resources (DNR).
Information regarding petitioning to replat existing lot lines in the Unorganized Borough is included here because it is handled under the same process and regulations as easement vacations.
The following types of easements require DNR approval for full or partial vacation:
- Section-Line Easements of any width
- RS 2477 Rights-of-Way
- Easements "To and Along Public Water" created per AS 38.05.127
- Alaska Division of Lands (ADL) Right-of-Way
- Any other easements reserved and managed by DNR
In the Unorganized Borough all of the above plus the following require DNR approval:
- Platted Right-of-Way dedicated to Public Use
- Public Access Easements
- Replats
- Replats plus any combination of the above
The vacation of section-line easements and RS 2477 rights-of-way also requires the approval of the Department of Transportation and Public Facilities (DOT/PF). A petition filed with DNR will be automatically forwarded to DOT/PF, along with copies of the required submittals, and applicants are not required to petition DOT/PF directly. The Survey Section will also solicit review comments directly from other state agencies.
The supporting materials required along with the petition and application fee differ according to the location and type of action requested. There are three different situations:
1. Easement Vacations Within a Local Platting Authority
Local platting authority is granted to organized boroughs and incorporated cities and municipalities. If your property lies within a incorporated city or borough, you should contact the appropriate office to determine whether or not they are exercising their platting authority. If you are unsure how to contact the local government, the Division of Community Advocacy maintains an online Community Database that we have found to be helpful.
Instructions for Easement Vacation Petitions Within a Local Platting Authority
Easement Vacation Within a Local Platting Authority - Petition, Instructions and Other Information
Application Fee - $750
2. Easement Vacations in the Unorganized Borough
If there is not a local platting authority, then DNR is the platting authority, in accordance with AS 40.15. Within the Unorganized Borough, the vacation or alteration of any public easement or right-of-way of record is a vacation subject to the requirements of AS 29.40.120-.150 and AS 40.15.300(e).
Instructions for Easement Vacation Petitions Within the Unorganized Borough Platting Authority.
Easement Vacation in the Unorganized Borough - Petition, Instructions and Other Information
Application Fee - $750
3. Replats in the Unorganized Borough
Within the Unorganized Borough, if new subdivision lotting overlaps, or in any way alters platted lot lines, it is a replat subject to the requirements of AS 29.40.120-.150 and AS 40.15.300(e). Protracted lot lines, depicted as dashed lines, on GLO or BLM rectangular survey plats approved by the federal government are lot lines of record and subject to the same regulations if replatted.
DNR Policy (with examples) - When a Replat Petition is Required
Replats in the Unorganized Borough - Petition and Instructions
Application / Survey Instruction Fee - $50
Downloads useful for drafting:
- SLEV Sample Plat in pdf format.pdf
- SLEV Sample Plat Release 12 Autocad format.dxf
- Standard Legend in pdf format
- Standard Legend in Autocad R12 dxf format


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ONDA - Office National de Diffusion Artistique |
IntroductionCreated in 1975 at the initiative of the French Ministry for Culture, its mission is to help the diffusion in France of performances lying within the scope of contemporary forms. Encouraging touring, its actions allow audiences, wherever they are, to discover artistic researches participating in forms renewal. Taking part in international networks, Onda contributes to the development of artistic exchanges through a financial support to foreign productions touring in France. StructureBringing together energies, Onda carries out its mission in collaboration with partners and finds its efficiency in its ability to summon up interests, stimulate discoveries, and foster collaborations. It is composed by a small team of committed professionals who, out of flexibility, constantly adapt to the ever changing issues of contemporary creation and diffusion. ActivitiesKeeping up to date on contemporary creation, spotting new experiences and budding talents, knowing venues and artistic teams…Discovering is daily work for Onda. Onda's team is made of professionals with practical backgrounds, using their experience to


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Midwest Living Review
No matter what time of year you go, visitors to the Hocking Hills come here to explore Hocking Hills State Park, one of the region's best. You wouldn't plan a visit here without stopping at the park, which has six distinct natural areas, though a handful of standout accommodations are destinations in and of themselves (including the Inn and Spa at Cedar Falls and the adults-only Glenlaurel country inn). You could spend a week at the park and not hike it all, so be choosy about what kind of experience you want to have. If you're looking to see the wow attractions right off the roads, head to Old Man's Cave and Ash Cave; if you'd prefer a quiet communion with nature, come during the week and try Conkle's Hollow. If you don't mind climbing stairs, descend to the base of Cedar Falls. For more information, stop at the new welcome center off US-33.Otherwise, the new Hocking Hills ATV Rental and zipline are both fun, even for beginners, and nearby Nelsonville has a town square with a handful of cute shops, an old opera house that still hosts concerts and Rhapsody, a killer fine-dining restaurant where culinary students staff the kitchen. Logan, while closer to the park than Nelsonville, has seen better days and offers little beyond a coffee shop for visitors too eager to explore. Outside the park, the region offers a mix of pretty farmland and ramshackle houses, both remnants of the region's heritage.


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Eagles vs. Bengals: Backup QB Trent Edwards is Nick Foles' biggest fan
PHILADELPHIA — No one has influenced Eagles quarterback Nick Foles more this season than Trent Edwards, the Stanford geek who has molded his rookie counterpart into a lean, mean fighting machine.
When Foles fired that winning touchdown pass to Jeremy Maclin as time expired in Tampa, Edwards felt a little like he was in a hospital delivery room.
"I was extremely proud," Edwards said. "It's one of those things where, I don't want to say proud father but I've been with him for six months now. There's practice, training camp, OTAs and all the film you watch. To have it kind of come together in one moment right there where it's the last play of the game, where he came to the sideline, called the play and then executes the play and then we walk off of that field with the win you just feel happy, proud. There's a variety of adjectives I could give you … I'm just happy for Nick."
Edwards will be happier for Foles if the third-round pick out of Arizona can hang in there tonight when the Eagles oppose the Cincinnati Bengals at Lincoln Financial Field (8:20, ABC, WIP 94.1-FM).
The Bengals (7-6) are better coached than the Buccaneers, who ranked last in the league in passing defense. Defensive coordinator Mike Zimmer invents a new zone blitz package weekly. Defensive end Geno Atkins (10½ sacks) has games in which he's unblockable. The Bengals lead the league in sacks. They bring a lot of heat right up the middle.
While Foles threw for 381 yards and two touchdowns, and rushed for another score, he was sacked six times in the 23-21 win over the Bucs.
"I'm going to have to do a great job with blitz pickup and we need to execute our offense," Foles said. "We need to run effectively and throw effectively. The big thing is to run our offense well and execute well."
Edwards will do everything he can to prepare Foles for the Bengals. The same can be said of the Eagle coaching staff, acutely aware how important it is to get rookie running back Bryce Brown untracked this week. To beat the Bengals pass rush down, you've got to run. It's that simple.
"They do a lot of things with fire zones and blitzes that you have to be ready for, and I'm talking from a quarterback's standpoint and a protection standpoint," Eagles coach Andy Reid said. "They do everything that you can do to maximize a defense, and they're going to show it to you."
The Eagles and Foles began game-planning for the Bengals when they weren't trying to figure out the Bucs. Edwards explained how he strategically text messages highlights and key points to Foles along with the obvious — don't be late for this meeting or that meeting. To say the duo is close is an understatement. Foles offered Edwards a place to live for two months. Continued...
"On a regular basis we're pretty close," Edwards said. "And that just comes with the territory. I think you kind of have to be that way. He's helping me out a lot and I hope I'm helping him out, too."
Foles credited Edwards and veteran quarterback Michael Vick, among others, with aiding in his development. Foles always is careful to include all of his teammates and avoid even a shred of controversy. Reid said Edwards has helped prepare the rookie to take on the media.
"When Nick is here, Trent is here — they do all of this stuff together," Reid said. "I just think it has been a real positive for him in terms of understanding the game, not only the game schematically, but the game as a whole with the media and all the attention and everything that comes with it."
Edwards, who doesn't have a Twitter account, says Foles recognizes how to act off the field without his help. Whatever assistance Edwards provides, it's easily remembered.
"I think the big thing is to be who you are," Foles said. "I'm going to tell you how I feel and I think you just stay true to who you are as a person. That's what I've talked to him about."
Foles has thrown three touchdown passes and no interceptions in his last two starts after getting intercepted three times in his first two starts. It won't be a coincidence if Foles does well against the Bengals.
Though it's early, Edwards believes Foles is special.
"I always have," Edwards said. "I've always believed in him and I've felt like he's got — I don't know if moxie is the word — but just the right mentality.
"There was a play in the Dallas game when he got hit probably as hard as he's gotten hit in a long time. The very next play it was third-and-10 and he completes a ball inside to a slot receiver. I always judge quarterbacks based off of plays that they make after they get hit really hard. If they can stand in there and execute.
"And he's done that on a consistent basis." Continued...
Even a proud pop can't ask for much more than that.
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Top Sports Stories
- Bob Grotz's Eagles Checklist: Looks like Bengals win
- College Hoops: Chester's Rahlir Hollis-Jefferson gets 20 as Temple tops Towson 72-61
- Saint Joseph's suspends Halil Kanacevic 2 games for obscene gesture to 'Nova fans
- McCaffery: Sixers have rare chance to grab fans' full attention (With Video)
- Punch Shots: Kanacevic paying penance for his sin
- Joakim Noah fired up as tired Bulls romp over 76ers (With Video)
- Sixers Scoop: Arnett Moultrie gets to delay D-league demotion


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Daily 10
Daily PatchCast: Behind the Scenes at 911, Kirkwood Victims ID'd, Fire Safety Lessons at GT
The day's top headlines for Thursday, September 15, 2011
ChatComm Opens Its Doors For Dunwoody Residents. Harmony Grove Headstones Restored. Kirkwood Murder, Suicide Victims Identified. St. Paul's Episcopal Church Homecoming. Dude, Don't Set The Dorm Room On Fire.
In this Article:


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text: Trevor Greene By Bonnie Davidson July 10, 2012 1:19 PM Share on Facebook Share on Twitter Category: Send to a friend! Print this page Share on Facebook Share on Twitter Pin it! Reddit This! More from newstalkkit.com Memorial Day Is all about Committment 'Doodle 4 Google' Winner Depicts Moving Soldier Homecoming Avalanche Control Work On Chinook Pass Planned Today Where is the Best Place to Give Money to Help Tornado Victims? Best of the Web ZergNet


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I need a defensive pokemon to be able to last a bit longer in battles, but not a pokemon with too many weaknesses. Some people have already suggested that I try bronzong, and I have taken him into consideration, but can I hear some other ideas? Give me reasons to use the pokemon, I'm looking for something with good defensive stats (HP/Def/Sp.Def) Note this is a pokemon on a sandstorm, so most likely a ground, rock, or steel type would be good. (if not a pokemon with magic guard or overcoat) I can find just about any pokemon, so don't limit your idea's to any single game.
(This is my first time asking a question, so I hope I'm doing it right)
85 Hp is good 130 Defense is AMAZING! 70 S.Defense is not very good, but with Sand boost it gets boosted by 1.5 which makes it great!
His movepool is far from perfect but it has enough to make him a powerful wall.
70 Hp is good 180 Defense is HUGE! 60 S.Defense stinks, but again the Sand boost makes it great
His movepool is great and has plenty of useful tools in Offense and Defense.
80 Hp is good 200 Defense is INSANE 100 S.Defense is great and with Sand boost is insane.
His movepool is also great.
80 Hp is good 150 Defense is AWESOME 150 S.Defense is AWESOME
Great movepool.
80 Hp 130 Defense is AMAZING 90 Defense is great, and he can learn Light-screen to boost the entire teams S.Defense
His movepool is awesome as well!
How to change your username How to add a user avatar Why was my post hidden? The points system Question etiquette Flags vs Downvotes Anime FAQ
Type a Pokemon name, type, move or ability to see instant results.


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Barbara A. Eshenaur, age 74, of Orrville, Ohio, passed away on October 30, 2012, at Affinity Medical Center in Massillon, Ohio, following a short illness.
She was born on July 24, 1938, in Gallipolis, Ohio, the daughter of Troy and Esther (Lambert) Russell. She was united in marriage to Dr. Oliver C. Eshenaur on July 26, 1968, in Connersville, Ind. He died on May 6, 2010.
Barbara graduated from Point Pleasant High School in 1956, and received her RN degree from the Joseph School of Nursing in Parkersburg. She had worked as an RN for Dr. Oliver Eshenaur's father, Dr. Roy Eshenaur, at his medical clinic in Point Pleasant.
Barbara enjoyed gardening, flowers, playing the organ, and especially enjoyed her grandchildren. She also enjoyed shopping in general, and especially during the Christmas season. She was a member of the Orrville Christian Church.
She is survived by three sons, Alan Eshenaur and Raymond (Traci) Eshenaur, both of Orrville, Ohio, and Richard (Kelley) Eshenaur of Chesterton, Ind.; step-daughters, Pamela (Chris) Ion of Gaithersburg, Md. and Theresa (Andy) Wickline of Gallipolis, Ohio; step-son, William Eshenaur of Sacramento, Calif; six grandchildren; six step-grandchildren; and sisters, Jean Gaskins of Point Pleasant and Dee Chambers of Roanoke, Va.
In addition to her husband, she was preceded in death by her parents, and a step-daughter, Julie Fay.
Services will be held at 2 p.m. on Monday, November 5, 2012, the Orrville Christian Church with Pastor Tom Ledford officiating. Burial will take place at Crown Hill Cemetery in Orrville, Ohio.
Friends may call from 6-8 p.m. on Sunday, November 4, 2012, at Auble Funeral Home, 512 E. Oak St., Orrville, Ohio. Online registry and expressions of condolence may be made at the funeral home's web site at www.aublefuneralhome.com.
Memorial contributions may be made to the Orrville Christian Church, 925 N. Elm St., Orrville, Ohio 44667.


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Multilateral development cooperation of the Czech Republic
30.08.2012 / 14:59
Given how global the present-day world has become, and how complex the issues it faces are, development goals cannot be achieved via bilateral cooperation alone. In order to achieve significant lasting improvement in the situation of poor countries, coordinated global action is necessary, including a wide range of policies concerning international trade, climate change measures, tax issues, corruption, migration, security and so on.
In this respect, the Czech Republic works with a number of international organisations that strive to reduce poverty on a global scale. The country regularly joins activities organised by the United Nations, the European Union, international financial institutions and other intergovernmental organisations.
The ways in which the Czech Republic becomes involved in the activities of international organisations are varied: by direct participation of Czech experts in specific development projects implemented by the various organisations, or via contributions focusing on specific activities that the organisation pursues in the developing world, with annual contributions towards the organisation's budget being the most basic method of participation.
Besides these compulsory contributions, which arise directly from the country's membership in a given organisation, the Czech Republic annually provides voluntary funding to a number of organisations, while also trying to increase the involvement of Czech experts.
The Czech Republic is also represented in executive and other bodies of various organisations, thus contributing towards defining their strategy and general action plans.


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2006 – Platinum celebration in ZurichIt was in Zurich on November 24th 2006 that Vacheron Constantin chose to celebrate the rarest, most precious and most timeless metal of all – PLATINUM.
The watch brand that has been in uninterrupted activity for over 250 years succeeded in transforming the premises of the legendary Kaufleuten establishment to create a genuine didactic exhibition for the occasion, open to the public and precisely retracing all the stages in the production of this metal – from extraction through to refinement.
This exhibition day was preceded by a VIP dinner hosting over seventy friends of Vacheron Constantin, including many platinum connoisseurs and devotees.
Légendes-photos :
- Mr. Heinz Forrer, Brand Manager Vacheron Constantin for Switzerland


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The ISOQUANT® Isoaspartate Detection Kit is intended for quantitative detection of isoaspartic acid residues in proteins and peptides, which can result from the gradual, nonenzymatic deamidation of asparagine or rearrangement of aspartic acid residues during storage or handling.The ISOQUANT® Kit provides reagents for deamidation detection using an HPLC method. The amount of isoaspartic acid to target protein is determined by comparison with reactions performed using a reference standard peptide.
Printed in USA. Revised 10/11.
Complete Protocol PDF (977kb)
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The Milwaukee County Medical Examiner's office said two people were killed in overnight shootings.
A Milwaukee Police Department spokesman said the shootings were reported at a home near South 27th and West Scott streets around 1:30 a.m.
Neighbor Maribeli Alvarez was awakened overnight and confronted by an image she said she will never forget. She and her brother-in-law found a man lying on the grass on the corner.
She didn't recognize the man and said he wasn't moving, so they called 911.
"He didn't have no shoes on, or no coat on. We thought maybe he was just drunk, so then we called the ambulance and found out he was gone," Alvarez said.
Sgt. Mark Stanmeyer said a 44-year-old man died of an apparent gunshot wound.
Stanmeyer said that during the investigation, officers also discovered a 29-year-old man dead inside a nearby home.
Investigators said the shootings are related, and the violence has shaken neighbors.
"Yeah, it was scary," neighbor John Voit said.
Voit lives a few doors down. He said this isn't the first shooting and probably won't be the last.


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Tag Archive
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Color Me Clean! New Boon Products at Babesta Soon!
Color me clean! Boon, the king of Grub N Suds in full color, is just releasing some new hues to make those routines less, well, routine! In the deep dark depth of bubbles lie the new Boon creatures – interchangable bathtime cups for filling, pouring, playing and fun. Dive, Trap and Trace the [… Read More]


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Child on bicycle dies after being hit by truck
A child bicyclist who was struck by a truck on Western Avenue on Friday has died, police have confirmed. Officials say the child was in critical condition when they arrived, and he was pronounced dead at the UT Medical Center. Police have not yet released the victim's name. An investigation is ...
White Knuckle splits in two amid controversy
(WBIR - Huntsville) Memorial Day weekend is a time of the year many ATV riders look forward to. Hundreds of riders have arrived to Scott County for the annual 'White Knuckle' ATV festival. Nicole Roshon of Loveland, Ohio said, "This is our third time down here. We come down here because of the variety of trails and mostly every place we go it's not necessarily about the ...
Gold Star family members fallen servicemen honored at Governors Memorial Day Ceremony
Gov. Bill Haslam paid tribute to the memories of Tennessee troops killed in action and to their surviving families as he proclaimed Friday the first Gold Star Family Day in state ...
Destination Imagination hosts Global Finals offers interactive learning competitions
photos by MICHAEL PATRICK/NEWS SENTINEL Milan High Red Eye team members get the first look at their invisible ';Phantom of the Opera'; member, who appears to them at the end of the skit, at the Destination Imagination competition Friday. DI is an interactive academic competition held annually in Knoxville that features more than 1,200 teams and 16,500 competitors from more than 15 ...
BPV mutual funds pass $100M mark
In 2011, the company announced the creation of two publicly traded mutual funds -- the BPV Core Diversification Fund and BPV Wealth Preservation ...
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Movie Review
Iron Man 3
Now that the Iron Man movies have reached entry number 3 (if we can consider, ala Federico Fellini, that the characters appearance in last summers The Avengers counts as at least half a movie), we can safely say that the series has matured into one of the more resili ... ...
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Families speak out about Bean Station victims
(WBIR- Bean Station, Tn) As police continued the investigation into the Bean Station shooting, family members spoke out Friday about the victims. The son of a Richard Alexander Sommerville, who was killed in a shooting Thursday at a Bean Station pharmacy, remembered his dad as a lively person and proud grandfather. "If he was in a room or at a party, he was definitely going to be ...
Lenoir City grads get botched diplomas
Some Lenoir City High School students thought there was something that didn't look quite right when they received their diplomas at graduation last ...
Closing on EnergySolutions merger
EnergySolutions and Energy Capital Partners today announced the closing of their merger. EnergySolutions stockholders earlier approved the merger agreement in which they would receive $4.15 cash per share, according to report by the Salt Lake City ...
Unclaimed Vietnam veterans laid to rest with honors
Three Vietnam-era veterans were laid to rest Friday with full military honors, years after their deaths. Sergeant Roger Thompson and Private First Class Fred Hall died in January 2010. Private Gary Sharp died in April 2011, but their cremated remains went unclaimed at the East Tennessee Regional Forensic Center. The Missing in America project contacted the medical examiner's office ...
Tennova dedicates expanded emergency room
Tennova's North Knoxville Medical Center dedicated its newly renovated and expanded emergency room on Friday. The emergency room is now a 20-bed facility, up from 16. All treatment rooms received new furnishings and updated, state-of-the-art equipment. The 12-week expansion project cost $720,000. The North Knoxville Medical Center is one of East Tennessee's newest hospitals. It ...
Making the news
We must define the nature and scope of this struggle, or else it will define us. Neither I, nor any President can promise the total defeat of terror. What we must do is dismantle networks that pose a direct danger.
Barack Obama
The U.S. president was speaking on his administration's counter terrorism policy.
Hotel Review
The Plaza, New York City
The Plaza had two entrances, both attended by a Concierge. On arrival my car was greeted enthusiastically with assistance with ...
Keep readingRecord Your Vote
The Boy Scouts of America National Council has resolved to accept gay members. Do you agree with this policy?
Knoxville Times
Knoxville Times – News Portal for Knoxville, TennesseeThe Knoxville Times is essentially a local Knoxville newspaper, but with a national and international perspective, designed to provide readers with a one-stop shop for Knoxville, national US, regional, and world news coverage, weather and sports information, with live updates on breaking business stories, and what's happening in the financial markets.
The biggest advantage we have is that we are an online newspaper, which means we are constantly refreshing our stories as more and more information comes to hand. Often when a story breaks the initial details are sketchy.
We and our sources around the world work hard to gather more information, verify facts, and provide a perspective of the major stories. Expert opinion often accompanies our articles to better inform readers, and provide a more complete understanding
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text: The Vail Valley makes it easy to enjoy all of the fun and adventure of the mountains without lugging a bunch of equipment on the airplane or in your car. Rental shops in the valley offer state-of-the-art skis, snowboards, bikes, golf clubs, fishing equipment and ice skates to enhance your fun and reduce the hassle. Many rental shops will deliver and pick up your equipment. So leave your gear at home.


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+Burglary suspect linked to other crimes
The Sarasota County Sheriff's Office charged Rene Jose Sanchez with Fraudulent Use of a Credit Card in connection with Siesta Key vehicle burglaries.
+Karen Carpenter was unanimously voted the board's new leader
Karen Carpenter was unanimously voted the board's new leader Nov. 20.
+WEEKEND BEST BET: Santa Jaws arrives at Mote
The Mote Marine Mascot, Gilly, will show his holiday spirit tomorrow and the first three Saturdays in December.
+WEEKEND BEST BET: Downtown Sarasota Village Lighting of the Trees
Celebrate the first annual lighting of the trees event this Saturday.
+WEEKEND BEST BET: Siesta Key Light up the Village
Come out to Siesta Key to "light up" the Village.
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- May
22 Lakewood Ranch Business Alliance May Morning Express Networking Social - SCF "How SCF Supports Local Business"
7:30 am - 9:00 am - May
26 Tribute to Heroes Parade - Main St LWR
5:00 pm - 9:00 pm - May
28 Braden River Soccer Club Try-outs
6:00 pm - May
29 LWRBA May Membership Lunch
11:30 am - 1:00 pm
Ranch rallies against cancer
East County residents will rally to fight cancer Saturday, May 18, as the American Cancer Society hosts its annual Lakewood Ranch Relay for Life event at the Lakewood Ranch YMCA. -
Barista pours on fun for daughters
State Road 70 Starbucks barista and East County resident Cyndee Vanderford showed her daughters the world of lattes and mochas for Take Our Daughters and Sons to Work Day April 25. -
Troop plants Freedom's courtyard
Girls in Girl Scouts Junior Troop 181, at Freedom Elementary School, recently earned their Bronze Award by researching and planting the back of the school's courtyard.


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Hi all,
I recently got laid off and I've decided to move to another province (Alberta) to seek work. I'm trying to determine whether or not I'll be able to claim my trip across the country and it would really affect how I travel - currently I'm being frugal and plan to tent across the country; but if I am confident I can claim the move perhaps I'd treat myself to a couple of hotels along the way.
CRA's website, as well as most blogs and new articles, state the 40KM limit over and over - that part is no problem. But CRA's website seems to imply that you have a job lined up BEFORE you go.
They also say that one can't claim job hunting trips; but to me, a job hunting trip would be a return trip to a new city where you have an interview for a position and obviously this isn't covered.
So, in short, my situation: I plan to relocate. I'm confident I'll find work, but I may spend 2 months looking. It's just not reasonable to line up the job from the other side of the country.
My question: Should I (Can I) claim expenses for this trip?
Thanks for any advise you can offer!


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May. 25, 2013 11:30 am (CT) Baseball vs. LSU/Alabama (SEC...
No. 4 Razorbacks collect six NCAA qualifiers
Hope McLemore named Academic All-American
Watch NCAA Women's Golf
Jeske and Nott advance to round of 16
UA downs LSU; advances to SEC semifinals
Arkansas tied for 15th at NCAAs
Tesfaye qualifies, seven advance on day one
No. 4 Razorbacks take on NCAA West Prelim


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"Science is more essential for our prosperity, our security, our health, our environment, and our quality of life than it has ever been before."
- remarks by President Obama at the National Academy of Sciences Annual Meeting on April 27, 2009
Join the community of the country's top computational scientists and engineers.
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The tremendous benefits and opportunities these students receive have a lasting impact on their lives.
Fellow Reflections
Sarah Richardson
Johns Hopkins University School of Medicine
Field of Study: Human Genetics & Molecular Biology
Practicum: Lawrence Berkeley National Laboratory
Hometown: Baltimore, Md.
Tal Danino
University of California, San Diego
Field of Study: Dynamics of Systems Biology
Practicums: Lawrence Berkeley National Laboratory (2008, 2009)
Hometown: Tarzana, Calif.
Milo Lin
California Institute of Technology
Field of Study: Physics
Practicum: Brookhaven National Laboratory
Hometown: Los Alamos, N.M.
Brenda Rubenstein
Columbia University
Field of Study: Theoretical Chemistry
Practicum: Los Alamos National Laboratory
Hometown: Saddle Brook, N.J.
Alejandro Rodriguez
Massachusetts Institute of Technology
Field of Study: Condensed Matter Theory
Practicum: Lawrence Livermore National Laboratory
Hometown: Miami, Fla.
Anne Warlaumont
University of Memphis
Field of Study: Computational Developmental Psycholinguistics
Practicum: Argonne National Laboratory
Hometown: Chappaqua, N.Y.
Jack Deslippe
University of California, Berkeley
Field of Study: Computational Condensed Matter Theory
Practicum: Oak Ridge National Laboratory
Hometown: Mount Pleasant, S.C.
Special Announcements
Ten New Fellows Named
Congratulations to the 2013-14 incoming class of DOE CSGF recipients who will begin their studies in the fall. Read more.
Register Today!
Online registration is now open for the 2013 DOE CSGF Annual Program Review to be held July 25-27 at the Crystal Gateway Marriott in Arlington, Va. Visit the website to view the complete agenda, make travel plans and hotel arrangements, and register for this important meeting of leaders in computational science and engineering.
Alumna's Work Published in PNAS
The infant vocalization research findings of Anne Warlaumont and her University of Memphis colleagues were recently published in the Proceedings of the National Academy of Sciences (PNAS). Read more here.
Events, Deadlines & News
Hotel Block Closes
2013 HPC Workshop
2013 DOE CSGF Annual Program Review
Reimbursement Materials Due
DOE CSGF Publications
DEIXIS Magazine – DOE CSGF Annual
DEIXIS was developed in 2002 as an annual magazine for the DOE Computational Science Graduate Fellowship program.
DEIXIS Online
The online edition of DEIXIS complements the print edition by featuring articles about computational science at the DOE laboratories.


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The folks at Nielsen have confirmed what we've long suspected--we waste more time on Facebook than anywhere else. The famed media metrics and ratings company says in its latest social-media report that Americans spend more time on Facebook than any other destination on the Web--about 53 billion total minutes in the month of May 2011 alone.
That's even more time than we spend streaming Pandora, which last quarter ate up 1.8 billion hours of listening time, an activity that requires much less interaction, or even being in the room. The Facebook tally is also just short of the amount of total hours spent by gamers playing on XBox Live, which at one point last year Microsoft estimated to be a total of a billion hours a month. That's a global number though, so take away all those overseas game junkies, and odds are that Facebook is still bigger here in the land of the free and the home of the Liked.… Read more


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"We offer you an interdisciplinary, market- and praxis-oriented degree programme with progressive teaching and learning methods and a personal atmosphere at a modern university. This graduate R&D degree programme offers you further, more in depth concepts, methods and techniques that will enable you tosolve complex problems and develop new technologies independently."
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Use this kit of visuals to add interest, excitement, and increase understanding of your lesson. Includes printed maps, charts, art, and colorful photography. The CD provides these resources digitally as well, in addition to PowerPoint(R) presentations for each lesson and reproducible student pages. Order 1 per class. PowerPoint(R) is a trademark registered in the United States Patent and Trademark Office by Microsoft Corporation. Used by permission.
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Need help selecting the appropriate Curriculum Resource?Be sure to check out our Curriculum Finder to help you find the right resources for your group.


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Green-Energy Mandates Will Hit PA's Poorest Hardest
Costly Mandates: A Pennsylvania state law will cost consumers $16 billion over eight years, according to a new report.
By Eric Boehm | PA Independent
HARRISBURG – A state mandate that requires electric providers to use more renewable and alternative sources in coming years will drive up the cost of electricity for all Pennsylvanians by $16 billion over the next eight years, according to a new study.
Worse, the costs will fall hardest on the state's lowest income residents, making the alternative fuel requirement similar to a regressive tax.
"A small increase in electricity prices is really going to hit them, as a share of their spendable income, much harder than the upper income groups," said Michael Head, a research economist for the Beacon Hill Institute at Suffolk University, a free-market think tank that conducted the study.
The state mandates were created by the Alternative Energy Portfolio Standards Act of 2004, which requires utility companies to include increasing amounts of alternative energy in their overall production totals. The law requires that 18 percent of all energy sales in Pennsylvania come from alternative sources by 2021.
It requires that 8 percent come from renewable energy resources – like solar and wind – and another 10 percent come from alternative energy sources, including waste coal and large-scale hydroelectric power.
The problem for consumers is that those types of energy are more expensive to produce than such traditional types as natural gas or coal.
"The law mandates that you use a more costly form of energy production, which will drive up costs," Head said.
All told, the energy mandates will cost Pennsylvania consumers and businesses about $16 billion over the next eight years, the study concludes.
That means more than just pricier electric bills for residents of the state. The study projects a loss of about 17,000 jobs as companies either leave the state or are prevented from hiring because they have to spend more money on electricity.
That net loss includes an estimate of employment growth that would result from the state's mandatory investment in alternative energy, Head said.
State Rep. Chris Ross, R-Chester, one of the sponsors of the Alternative Energy Portfolio Standards legislation back in 2004, said the rules allow residents to actually offset their energy costs by producing small-scale solar energy which can be sold back to the power grid.
That helps not only low-income electric users, but all residents of the state, he said.
"It can actually reduce the cost for lower-income houses," Ross said. "So I think energy conservation is not at all regressive. It can be quite the reverse."
But Ross' solution comes with its own cost to the taxpayer: the state has run several grant and loan programs to incentivize people to install such solar power devices.
And a 2007 report from the state's Public Utility Commission found that the cost of solar energy in Pennsylvania was seven times higher than getting the same energy from a coal-fired generation plant. The same study reported that solar power was about four times as expensive as wind energy, making it one of the most expensive forms of alternative or renewable energy.
Jennifer Kocher, spokeswoman for the PUC, said the commission believes meeting the targets in the legislation will have "an impact on consumers in terms of rates," though they do not have specific figures.
Ross said the cost of generating electricity from alternative sources is on the decline. He said the Beacon Hill Institute report did not accurately account for that fact.
George Jugovic, CEO of PennFuture, a environmental group based in Harrisburg, said tradition fuels come with other costs that go beyond the price of producing electricity. He specifically pointed to costs the state incurs for cleaning up old mines, dependency on foreign oil and public health issues created by pollution.
Are higher costs a necessary trade-off to protect the environment by using renewable energy?
"The answer is yes," Jugovic said.
Head disagreed. While there is validity to wanting to reduce pollution, the higher prices in Pennsylvania will have no effect on worldwide emissions, he said.
"A state-level policy itself will have very minor, if any effects on emissions. It will just cause those jobs to go to other places," Head said.
Contact Boehm at firstname.lastname@example.com and follow @PAIndependent on Twitter.
2:21 pm on Friday, December 21, 2012
Too bad that this is what people voted for. We'll pay more for electricity so there will be less to spend at local restaurants and retail stores. When will we wake up?
2:28 pm on Friday, December 21, 2012
Ever notice how its only government government workers that can be so FAT they'd be unable to engage in any useful, productive, verifiable, valuable WORK a REAL employer would be WILLING to pay for?
Yeah, thats what the government does...for a premium!
Bob Pietrangelo
12:44 pm on Saturday, December 22, 2012
I believe it is Indiana and previously California, they would allow the installation of alternative energy had no upfront cost, the payments for the installations were made as part of your utility bill. The savings each month covered the cost of the installation payments. Why not do it like that. Home based systems are part of that 18% requirement.
11:51 am on Sunday, December 23, 2012
I am buying green energy and it only costs a few dollars more a month.


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Josephus wrote:ha! Isn't the south edge of Australia almost at the antarctic? -eHal thinks he's so smart.
There are no penguins in the northern hemisphere. That takes care of any weather issues.
Re: Murder Mystery
I could possibly buy that this is about a murder mystery. But I know the context this shirt was designed in. But this is just gross. NOT PG-13 as PG-13 is usually defined: "There may be depictions of violence in a PG-13 movie, but generally not both realistic and extreme or persistent violence. " (from http://www.mpaa.org/FlmRat_Ratings.asp) This depiction of violence is both realistic and extreme. Plus, this is actually one of the worst looking designs I have seen in the fog yet. Maybe I can't appreciate the halftones because I'm not a designer, but this looks like one of those cheapo 1980s shirts they sell to tourists on the beach. Disappointing this is in the fog.
cobolisdead wrote:It wasn't getting enough votes to stay in the hotness that much today, meanwhile that Penguin Loch Ness Monster was killing the top spot of the hotness all day. A pity as this was dominating for the first two days or so, and now its down to fifth. This really needs to climb back into the fog.
If I have to pick animals. I will always pick photorealistic ones over cutesy pandering penguins even if the cats don't make sense. Here's hoping this can get its spot back.
The subtle colors on cream shirt show off the cats expressions and details really nicely, great job! I'm disappointed this fell from the fog. Hope the community knows enough to rally and vote it back where it belongs.
spanishmel wrote:Your comment made me smile so big!!! Thank you!
eh, asphalt is done to death
marmls2m wrote:eh, asphalt is done to death
Agreed, but the colors of this are great! (It's better than asphalt-colored colors on asphalt.) I love this design and the colors really make it fantastic! Good Job
my sense is this won't print/wear well. what do others think on the "printability" of it?
Re: usual suspects
Love it, love it! Nicely drawn, 'cept for copying the kitty head. Would have worn this proudly.
Re: How we got pictures of the Yeti
I really like the simplicity of the design, but I wouldn't go for it for the same reasons: The camera is plain wrong, and the copy-flip-paste really bugs me. Please just redraw the dude on the left and resubmit! My little girl would love this!
melanion90 wrote:The fact is that all three of those shirts are sexual in nature. You can't go far from Nickelodeon before you find violence. Heck, within many on the cartoons on television you find guns, and violence. What you do not find in many cases is sex, or things that are sexual in nature. I am not arguing whether it is right or wrong that violence is depicted in the world as "okay" or "PG-13" and sex is not, I am just stating that it seems to be the case.
sure you do! Look at Shrek... for sure not rated R and there are sexual references about her soon to be prince "compensating," with the ogre and donkey winking and nudging each other. AND The magic mirror is having a mock dating game for Prince DuLoc. Talking about Snow White the host says, "Bachelorette number two is a cape wearing gal from the land of fancy. Although she lives with seven other men she's not easy."... these are clearly sexual references in PG-13 movies. Certainly there are also visual representation of sexually suggestive imagery in children's movies as well (i.e. the excessive mermaid cleavage in The Little Mermaid for one example).
mrwednesday wrote:There are no penguins in the northern hemisphere. That takes care of any weather issues.
Though there are puffins/the off brand birds who swim in icy waters. :P
I think this shirt would be just as effective without the blood spatter/brains being shot out. With that small change we still have an "on-theme" shirt without the needlessly graphic bit.
xtinaftw wrote:I assume this is supposed to be based on the song... You do realize the words and title are, "I Wear MY Sunglasses At Night" right?
oh, yes, i know the original lyrics--my submission with the plain "i wear my sunglasses at night" will be reposted shortly; there were some odd upload issues earlier today.
SailorButterfly wrote:I'll post again to say I'm satisfied with this. I just mainly didn't like the implication that this design was pandering, but really, that wasn't from you anyway. Here's the real mystery of the design: why would a cat kill a mouse and not eat it? XD
My cats bring me mice ALL THE TIME that they've killed and not eaten. Or ones they've not even killed and just want to play with.... I, for one, love this shirt and hope it prints. It's one of the better shirts I've seen in a while.
AdderXYU wrote:Read this thread and tell me if woot has double standards or not. Someone at shirt.woot has a daughter who is in love with One Piece fan-art, and the duo responsible for questionably on topic and repeatedly poorly executed work is providing it in place of immunity from the rules of the derby. That is the only explanation that I can possibly work out as to why, week in and week out, there are two users who could submit german cranberry apple pie bake-offs and not get rejected.
Gah, another disappointing derby, don't remind me! Still, I'm glad there's An Unfolding Mystery.
Re: Femme Fatale
Perhaps this is redundant, but like everyone else I have to commend you for the colors. Just gorgeous. Wonderful, clean illustration. Good job.
Oh man this better win!
Re: What the heck is in a hotdog?
I like the concept but it'd have been way cuter with a hotdog pondering the origins of his existence...with really cute fat animals in the thought bubble. Cute pigs sell.
Outstanding work. A great design, and the colors really invoke that mysterious detective story mood.
Hmmm...I hope this makes it back to the fog.... *mourns* Anyway, nice shirt!
Re: The Usual Suspects
I never owned Guess Who, so I thought it was playing off of the Brady Bunch opening, even though the faces don't match the Bradys.
dshindell wrote:How is this not on topic? Both the reason these lights come on and the amount of money it will cost you are always a mystery to most people. Apparently 10 people within the first three hours of it being posted thought it was on-topic. I call shenanigans on WOOT!
Shenanigans indeed, I love this shirt. It's always a mystery as to what those symbols actually mean.
Cormano wrote:Beautiful.
Thank you!
I like this one, it's pretty cool.
HeartlineTwist wrote:I'm personally interested that none of these rejections were violence based.
Here's one: Rejected because: A little too gruesome thanks
mitchellp wrote:So here's my second try at this! I made some adjustments on the baby platypus and turned him the other direction. And I'm liking it much better. And I hope you do too. Feel free to check out my original submission and give it a vote too. Basically, Mr. Duck is upset because he suspects the new hatchling belongs to the milkman, Mr. Beaver. Give me a vote if you like it! Thanks! Here's a close up.
I actually like the original one better, but I'll vote for this too
But it's still warm there, isn't it? I'm not smart where it counts. I just happen to know some random trivia about animals.
hookajoe wrote:My Arabic is a bit fuzzy, but that's definitely text above the biohazard-like symbol.
Hindi, I think? It's Ohm, which HAS been grounds for rejection before in a no-text derby, but so far this has gotten a pass. Maybe the artist will get lucky.
Re: Mystery of Cliché Island
A closeup might be nice...
martinda wrote:Im so sad i was really looking forward to buying this shirt!
Nooooooooooooooooooooooooooooooooooooooooo gdfckndmnt
virgquest wrote:Love it, love it! Nicely drawn, 'cept for copying the kitty head. Would have worn this proudly.
Thanks for everyone's kind comments. Imitation is the sincerest form of flattery and the kitty head was just intended to do that in some generic fashion. My original vision was for each figure to be drawn in the style of that artist. That is probably beyond my illustration skills and a lot of effort for work earmarked for rejection.
rellikeht wrote: The "yetis" (or one-eyed furballs) are exactly the same with one holding a misdirected camera. The mountains are dull and boring as well as what appears to be mounds of snow. The design seems rushed and makes very little sense. I don't understand why something this mediocre gets so much attention.
I completely agree. It's blowing my mind that this has so many votes. Kind of depressing.
Re: Mystery of the Three Seashells
Lol i'll need this when i eat at taco bell =-D
sbaszto wrote:sure you do! Look at Shrek... for sure not rated R and there are sexual references about her soon to be prince "compensating," with the ogre and donkey winking and nudging each other. AND The magic mirror is having a mock dating game for Prince DuLoc. Talking about Snow White the host says, "Bachelorette number two is a cape wearing gal from the land of fancy. Although she lives with seven other men she's not easy."... these are clearly sexual references in PG-13 movies. Certainly there are also visual representation of sexually suggestive imagery in children's movies as well (i.e. the excessive mermaid cleavage in The Little Mermaid for one example).
Sure, but the difference is that it takes a mind like yours and mine to know what those things mean, where as in most cases violence is pretty straight forward.
wootchawant wrote:two comments: 1) the shades are purposely positioned to look just fine on women--they will hit well above the bust. 2) the almost invisible face is the whole point, and the .psd final print form has the lines just a bit lighter to ensure that they will be printable. enjoy...
lol yeah... our boobs are not that high up
melanion90 wrote:Sure, but the difference is that it takes a mind like yours and mine to know what those things mean, where as in most cases violence is pretty straight forward.
Less drama at Threadless
Candihanks wrote:Less drama at Threadless
Always. But Threadless alum would most likely tell you in far more blunt tone what they thought of an entry that truly sucked.
JadenKale wrote:Always. But Threadless alum would most likely tell you in far more blunt tone what they thought of an entry that truly sucked.
Remember, at woot you can only vote up. At threadless, you can always vote down.
mitchellp wrote:There are only 3 beds. I hope one of these penguins is a girl
I only see two beds.... but yeah, either way, one of them should be a girl or something...
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If someone plays a Bomber squadron on you, and you counter with a Fighter squadron, the Bomber squadron is discarded with no effect. Now, if that opponent plays a second Bomber squadron on you, does that same Fighter squadron get to cancel it too?
about Concussive Blast, can i move a ship even if she have speed 0?
Can I play the Action Card with "Ramming speed" on the same ship I played a blast with first? If the ship that i use Ramming speed hit another, can i use direct hit or direct hit effect? Can i use Ramming speed in a ship with speed 0?
Can I play asteroids or Minefields without a ship present?
Can you do this: Play a Blast card then Direct Hit play another Blast card then another Direct Hit then another Blast card, many times?
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Well you have probably figured this out or moved on, but for posterity, I'll post some answers.
When a fighter intercepts a bomber, it then can't do anything else for the rest of the turn. So the second bomber would get through unless you play another card to cancel it.
Concussive Blast can move any ships, regardless of their speed.
A ship can be sacrificed with ramming speed after it has already fired a blast. I think you can play a direct hit and direct hit effect after using ramming speed, although I don't think you can use direct hit to fire another blast since there is no ship to fire it. You can sacrifice a ship with zero speed, but it will do no damage so the only reason would be to use a direct hit effect.
Asteroid and Mine fields can always be played on any player.
You can chain together a series of blast, direct hit, blast, direct hit, etc… until you run out of cards or one is canceled.
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Arya Mani MD, FACC
Associate Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program
Research Interests
Identification of cardiovascular disorders that have strong familial pattern
Research Summary
Despite our recent advances in Cardiovascular Medicine, the cardiovascular disease remains the leading cause of death in the world. With the break through brought about by The Human Genome project, we are now in a unique position to dissect the genetic causes of cardiovascular diseases to better understand the pathways that lead to disease in human and subsequently try to find therapies tailored to the specific genetic abnormality.
My interest is to identify cardiovascular disorders that have strong familial pattern. We identify kindreds with these disorders and collect DNA samples from the extended family members to proceed with the technique of positional cloning to identify the disease-causing genes.
Thus far, I, and my colleagues have mapped and identified several gene mutation for congenital heart diseases including patent ductus arteriosus and bicuspid aortic valve. Recently my group identified a gene mutation in LRP6, a co-receptor for Wnt, in a kindred with coronary artery disease and several metabolic phenotypes. We have shown that the mutation impairs a signaling pathway known as Wnt. We have created knockin and knockout mouse models of this gene and are conducting in vivo and in vitro functional studies using human cells, in vitro transfection models, human clinical studies as well as studies on lipid and glucose metabolism in mice in collaboration with Dr. Gerald Shulman, The GCRC, and The Mouse Metabolic Phenotyping Center. We are also investigating the genetic causes of premature coronary artery disease in South Asians. South Asians suffer largely from coronary artery disease in young ages and have high risk for developing diabetes, a constellation of phenotypes commonly referred to as metabolic syndrome. Our preliminary data suggests, that we have identified at least one gene locus for this disorder. We are currently collaborating with several medical centers across the world and in India to recruit new families and individuals with premature coronary artery disease with or without metabolic syndrome to refine the mapped region and identify the gene mutation.
We use several different techniques in our laboratory, which includes positional cloning using DNA microarrays, techniques used for protein chemistry, subcloning, tissue culture, confocal microscopy, FACS, real time PCR and animal model.
Extensive Research Description
My main mission in the Section of Cardiovascular Medicine has been Development of a Cardiovascular Research Program for identification of genetic causes of cardiovascular diseases and understanding of the disease mechanisms that lead to a variety of cardiovascular disorders. During first years of the faculty position my effort has been to establish an infrastructure that utilizes all resources at national and international level to identify extreme disease populations with major cardiovascular disorder and to recruit them for basic human Genetic studies. Through collaborative studies with physicians and scientist across the world we have been successful in identifying number of genetic mutations that are responsible for common congenital and familial cardiovascular diseases. Among disease genes that I and people working with me have identified are genetic mutations causing syndromic autosomal dominant patent ductus arteriosus and recessive causes of nonsyndromic patent ductus arteriosus. Since identification of a genetic cause of metabolic syndrome and CAD the major focus of my lab has been on study of the disease pathogenesis caused by this mutation. Detail of this follows. Coronary artery disease (CAD) is the most common cause of morbidity and mortality worldwide. A cluster of metabolic phenotypes known as metabolic syndrome has been established as a major risk factor for CAD. The mechanisms that link these phenotypes to one another and to CAD are not well understood. My research group has identified the disease causing gene in a large family with autosomal dominant early onset coronary artery disease (CAD), diabetes, hyperlipidemia, and hypertension. The mutation, substitutes cysteine for arginine (R611C) at a highly conserved residue of the second epidermal growth factor precursor domain in the LDL receptor like protein (LRP6), which encodes a co-receptor in the Wnt signaling pathway. To our knowledge this is the first gene that links CAD to hypertension, hyperlipidemia and diabetes. My goal is to dissect pathways that link this mutation to the individual phenotypes. A second mutation (R473Q) was identified in a large American kindred with early onset CAD and phenotypes that are consistent with the overall picture of the metabolic syndrome. In vitro studies have indicated that these mutations impair Wnt signaling. Genotype phenotype correlation showed that the mutations impact number of the metabolic phenotypes that are present in these kindreds. These findings have established a causal link between Wnt signaling impairment caused by LRP6 mutation and coronary artery/metabolic syndrome and raise the possibility of complex downstream effects of the mutation which warrants further investigation. Having unique access to the study kindred, we have had the opportunity to carry out clinical studies to investigate the mechanisms of disease. Oral glucose tolerance tests in nondiabetic R611C mutation carriers have shown that they are hyperinsulinemic, indicating that insulin resistance is likely the major cause of impaired glucose tolerance in the mutation carriers. The mechanisms of insulin resistance caused by LRP6 mutation are not known. A focus of my lab is to understand the pathophysiology of the metabolic syndrome caused by LRP6 mutation. We have created knockout, knockin, and LRP6flox/flox mice. Goal is to carry out metabolic studies to understand the mechanism of insulin resistance and hyperlipidemia. Defect in glycogen synthesis of the skeletal muscle is thought to be one of the major causes of insulin resistance. The rate limiting enzyme for glycogen synthesis, glycogen synthase (GS), is phosphorylated and inactivated by glycogen synthase kinase 3ß (GSK3ß). GSK3ß is negatively regulated by Wnt signaling activation. The expression and activity of GSK3ß is increased in lymphoblastoid cells of the mutation carriers. We hypothesize that LRP6 mutation directly affect glycogen synthesis by impairment of glycogen synthase activity. To examine this hypothesis and to identify the major site of insulin resistance, insulin-stimulated glucose disposal rate and sensitivity to insulin suppression of hepatic glucose output will be measured with infusion of [6, 6- 2H]-glucose isotope in both nondiabetic mutation carriers and non-carrier family members in the two kindreds. Glycogen synthesis and GS activity in the skeletal muscle biopsies of the mutation carriers and non-carriers will be compared. In addition, to explore the prevalence and spectrum of LRP6 mutations in patients with metabolic syndrome and CAD, a large cohort of patients with early onset CAD, diabetes and metabolic syndrome will be screened for non conservative mutation(s) in the coding region of LRP6. These studies hold great promise in providing important insight into the pathophysiology of metabolic syndrome and CAD and identifying novel biomarkers and therapeutic targets for these disorders. We have localized LRP6 to apical brush borders of the proximal renal tubules and are studying its interaction with NHE3, dopamine and adrenalin in vitro and vivo to study the effect of LRP6 on blood pressure. We intend to create an atherosclerosis model by crossing smooth muscle-specific LRP6 inactivated mice (sm22LRP6-) with LDLR-/- mice. We have also mapped two genes for early onset CAD in two independent large Iranian populations and plan to densely cover the linked interval with tag SNPs to identify linkage disequilibrium(s). Moreover, we have identified a disease causing gene for bicuspid aortic valve by positional cloning and have established association between aortic valve disease and number of non-synonymous SNPs within this gene. My goal is to combine genetic approaches with clinical and cell biological investigations in order to understand pathophysiology of these diseases with the goal of identification of novel risk factors and developing novel therapeutics.
Selected Publications
- Mutation in EGFP Domain of LDL Receptor-Related Protein 6 Impairs Cellular LDL Clearance. Wenzhong Liu, Sheida Mani, Nicole R. Davis, Nizal Sarrafzadegan, Paula B. Kavathas, Arya Mani. Circulation Research. 2008103:1280-8.
- Friedman T, Mani A, Elefteriades JA. Bicuspid aortic valve: clinical approach and scientific review of a common clinical entity.Expert Rev Cardiovasc Ther. 2008 Feb6(2):235-48.
- Mani A(Corresponding Author), Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson-Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP. LRP6 mutation in a family with early coronary disease and metabolic risk factors.Science. 2007 Mar 2315(5816):1278-82.
- Mani A, Radhakrishnan J, Farhi A, Carew KS, Warnes CA, Nelson-Williams C, Day RW, Pober B, State MW, Lifton RP. Syndromic patent ductus arteriosus: evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder. Proc Natl Acad Sci U S A. 2005 Feb 22102(8):2975-9.
- Mani A, Radhakrishnan J, Farhi A, Nelson-Williams C, Warnes, Lifton RP. Novel splice-site mutation may suggest an alternative mechanism and expands the phenotypic range of disease in a gene for hand heart syndrome. In preparation.


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I-10 to experience overnight lane ramp closures this week
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The 4th Street Bridge at the Harvey Canal is closed to marine navigation due to a mechanical problem, according to the Louisiana Department of Transportation and ...
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Train service in the busy New York-to-New Haven corridor may be restricted for days as officials investigate Friday's rush-hour collision of two trains in Connecticut -- an incident that sent dozens to hospitals -- officials said ...
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Last year, New Orleans welcomed 9 million visitors to the city, another fantastic success for the tourism industry. While this is impressive, it pales in comparison to the goal of 13 million visitors for the tri-centennial of New Orleans in ...
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Jefferson Parish police say they have arrested David Lewis and Stanford Randolph in connection with two May 16 armed robberies and an attempted ...
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Trojans Roll Past Augusta State
February 14, 2013McKnight Strikes Out Seven
ANDERSON, S.C. – With junior right-fielder Paul Como leading the way at the plate, Anderson erupted for a season-high 17 hits as the Trojans defeated Augusta State, 13-2, Thursday afternoon at Memorial Stadium.
Anderson improved to 3-6 on the season with its second consecutive win and has won three of its last four, while Augusta State slipped to 3-4 and suffered its third consecutive setback.
The Trojans posted their highest offensive output since topping Southern Wesleyan, 18-11, in mid-Aril last season, while the AU pitching staff has allowed just two earned runs over the last 18 innings.
Como was a perfect 5-for-5 at the plate, including a double and scored three times, while driving in a run. Freshman Chris Ayers was 3-for-5, with three singles and drove in four runs, while Nathan Galliford posted two hits and a walk in three at-bats and scored three times. First-baseman Steven Cooper notched a triple and a double and scored twice, with Ben Pendleton recording two RBI on an eighth-inning single.
Left-handed pitcher Stephen McKnight (1-1) earned his first win on the mound for the Black and Gold, surrendering two earned runs over 5 2/3 innings and striking out seven Jaguars and walking just one. The freshman gave up just three hits over the first five innings, as AU built a 4-1 lead. Three Trojan hurlers, Jacob Saxon, Mitchell Cooksey and Will Walls combined to shut down the Jaguars over the final 3 1/3 innings.
The Trojans worked Augusta State starter Trey McAvoy (0-1) for six earned runs off seven hits in four innings, saddling him with the loss. Jamie Suggs and Phil Dukes allowed seven runs off 10 hits over the final four frames for the Jaguars.
McKnight started off the contest by striking out the side in the first inning and posted four strikeouts in the first two frames, while AU, which recorded six extra- base hits on the day, went ahead 3-0 in the second inning. After loading the bases with one out, Ayers delivered a two-run single to left field that plated Galliford and Como. Shortstop Brett Cash followed with a two-out double to right-center to bring home Ayers.
Augusta State responded with a solo run in the third inning, as Andrew Cooley drew a one-out walk and scored on JD Sabo's triple to center. But McKnight settled down to strike out Bradley Dennis and induced Jeff Rice to pop out to Ayers at second to end the threat.
Anderson added a solo run in the fourth and put the game out of reach with a four-run fifth inning, taking an 8-1 lead while batting around in the order. Cooper led off the inning with a triple into the right-field corner and scored when Josh Hickman followed with a double down the left-field line. The Trojans added three runs with two outs, as Galliford's single through the left side scored Hickman and Ayers' single to right brought home both Galliford and Como, who earlier beat out an infield hit.
Rice recorded Augusta State's first home run of the season with a one-out blast to center in the top of the sixth, trimming AU's advantage to 8-2 but the Jags would get no closer as Anderson scored five times in the bottom of the eighth inning to set the final margin.
The Trojans wrap up their eight-game homestand and open South Atlantic Conference play with a three-game weekend series versus Lincoln Memorial this weekend. The first game of the series is scheduled for 6 p.m. Friday at Anderson Memorial Stadium.


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Lots - Murphy, NC
A bit of Tuscany in Western NC on the banks of Beaverdam Creek. This community of truly upscale log & log sided homes, offers a working vineyard, common area on Beaverdam Creek, a stocked pond & lots of green space, including a play area for the kids. Subdivision property also adjoins USFS. Vineyard Creek is also only minutes from a full service marina on Hiawassee Lake. This is not just another subdivision. It is a community where owners/friends enjoy sharing in vineyard care, the garden, fishing, dinner parties & mountain living. This lot has a view of the vineyard.
Get a detailed community profile report via email. Click here to get your copy right away.
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This $49,000 Land at VINEYARD CREEK WAY in MURPHY, NC is listed by Helen Russell . This $49,000 Land, located in the 28906 zip code , has the following property features: New Construction, Roof, Property Type. This VINEYARD CREEK WAY Land, located in Cherokee County, is listed under MLS listing number 168471, has beds, 0 baths, and has a listing price of $49,000. You can find more of Helen Russell's listings by browsing homes for sale at HomesAndLand.com, or even more MURPHY homes for sale here.


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1968 Ford Galaxie ConvertibleThis American classic has 65252 original miles and in great conditionFire Engine Red Metallic and with a two tone Red and... More
1968 Ford Galaxie 500 XL for sale in our Louisville showroom. The Ford Galaxie was the high volume counterpart to the Chevrolet Impala. Some... More


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1. | lifter | ||
1.Someone that steals goods from shops - a thief a (shop)lifter
2.A weightlifter. 1.Winona Ryder
2.Arnold Schwarzenegger (he is no politician!) |
2. | lifter | ||
1) Person who briefly takes his foot off the accelerator pedal at a moment where it is not called for. Person will usually fiercly deny the lifting.
2) Generally, half hearted person who does something wrong and/or uncool. Timmy lifted through Eau Rouge fo shizzle.
Just look at this bloke carrying a manbag, what a lifter! |
3. | lifter | ||
1. to lift one's shirt in order to provide access to the anus, ready for penetration. That guy is a clear-cut lifter, look at his outrageous fashion sense, hear his gay tongue and look at the way he he has a cock in his mouth!!!!
4. | Lifter | ||
A person who attempts to enrich others' lives by telling them who to hang out with/ what to wear/ what to say/ what not to say. "Don't do that! It's bad for your image! You'll thank me later." "What a lifter."
5. | Lifter | ||
Term from Maguiresbridge, Co. Fermanagh Northern Ireland, used mainly to refer to mephedrone but can also refer to other stimulants that are insufflated. Ya want a wee lifter?
6. | Lifter | ||
A serial killer who only kills inside elevators.
To Lift; to kill someone in a lift. To be Lifted; to be killed inside a lift. "Hey, did you hear that Lifters have their own website now? , Its called going up baby or something."


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NJ Sen. Frank Lautenberg says he will retire
By ANDREW TAYLOR
Associated Press
WASHINGTON (AP) — Democratic Sen. Frank Lautenberg of New Jersey, a staunch advocate of gun control and public infrastructure and a champion of the Amtrak railroad system, announced Thursday he will not seek re-election in 2014.
"This is not the end of anything, but rather the beginning of a two-year mission to pass new gun safety laws, protect children from toxic chemicals, and create more opportunities for working families in New Jersey," Lautenberg said in a statement.
Lautenberg, at 89 the oldest senator and the Senate's last veteran of World War II, has been easily elected five times, but he was facing a likely challenge from charismatic Newark Mayor Cory Booker.
He has also had health problems in recent years. He was diagnosed with cancer in 2010 — and successfully treated — and a case of the flu this winter caused him to miss the Senate's Jan. 1 vote on avoiding the so-called fiscal cliff of rising taxes and falling government spending. But he has beaten back health problems before — and a primary opponent who suggested he was too old for the job.
Lautenberg first won election to the Senate in 1982. He was set to travel Friday to his hometown of Patterson to announce his retirement.
In 2008, Rep. Rob Andrews challenged Lautenberg in a Democratic primary, but Andrews fell well short of unseating Lautenberg as most of the state's Democratic Party establishment continued to back him.
Lautenberg was diagnosed in February 2010 with B-cell lymphoma of the stomach and underwent chemotherapy treatments until he was declared in June 2010 to be free of cancer. He worked between the treatments. The diagnosis came just days after the death of Sen. Robert Byrd, D-W.Va., which made Lautenberg the oldest member of the Senate.
Lautenberg got into politics in 1982 after building a fortune as a founder of Automatic Data Processing. In that race, he defeated patrician Republican Rep. Millicent Fenwick, the model for the cartoon character Lacey Davenport in "Doonesbury," while spending $3 million of his own money.
In the Senate, Lautenberg has been a reliably liberal vote, crusading against smoking and youth drinking and supporting gun control and stiffer environmental laws.
"While I may not be seeking re-election, there is plenty of work to do before the end of this term and I'm going to keep fighting as hard as ever for the people of New Jersey in the U.S. Senate," Lautenberg said.
This isn't the first time Lautenberg has retired. He decided not to seek re-election in 2000, a move that opened the seat for Jon Corzine, who later served a term as governor of New Jersey. But Lautenberg was drafted back into politics two years later when scandal-plagued Sen. Robert Torricelli, a Democrat and Lautenberg's longtime rival, abruptly left the race in 2002.
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Oct 252009
Also known as
- Galacteon
Galation, a Christian, converted his wife Epistemis. They both then retired to monasteries and were later martyred in the persecutions of Decius. It's possible they were fictional, the story of their lives being written as fiction but misunderstood as fact; however, married couples agreeing to enter religious life was not unusual at the time.
Additional Information
- Book of Saints, by the Monks of Ramsgate
- Our Sunday Visitor's Encyclopedia of Saints
MLA Citation
- "Saint Galation". Saints.SQPN.com. 2 May 2013. Web. 19 June 2013. <>
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