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Remember Me
You can't stop the Amaz!ng Randi, and he's at it again with his Amaz!ng Meeting. This time it's TAM 6 and just like in past TAMs he's lined up some heavy hitters for this one of a kind conference.
Don't miss this opportunity to meet some of the leaders in the Skeptic movement. Randi is bringing back such great speakers as Phil Plait (the Bad Astronomer), Penn & Teller, Richard Saunders, Dr. Richard Wiseman, Dr. Michael Shermer, Adam Savage (from the Mythbusters), Christopher Hitchens and Paul Provenza. That's not even half of the speakers scheduled to attend.
Don't forget the special opportunity to have dinner with Randi and many of these fabulous presenters. Dinner with Randi and guests is a fundraising event and we welcome everyone that would like to attend. However spaces are limited so you should register right away.
Attendees must be at least 12 years of age to attend. Event speakers are subject to change without notice. If you would like to cancel your registration please know that a cancellation fee may apply.
Dr. Neil DeGrasse Tyson is an astrophysicist, and director of the Hayden Planetarium at the American Museum of Natural History. He served on George W. Bush's Commission on the Future of the United States Aerospace Industry, and was awarded the NASA Distinguished Public Service Medal for his work. He is President of The Planetary Society, and has authored eight books, including his memoir, The Sky is not the Limit: Adventures of an Urban Astrophysicist. Tyson is the host of the PBS program Nova, and is a regular guest on The History Channel's The Universe.
Dr. Michael Shermer is the Founding Publisher of Skeptic magazine ( www.skeptic.com ), the Executive Director of the Skeptics Society, a monthly columnist for Scientific American, the host of the Skeptics Distinguished Science Lecture Series at Caltech, and Adjunct Professor of Economics at Claremont Graduate University.
Matthew Chapman is a journalist, director, and author. He is the great-great grandson of Charles Darwin, and has written widely on the creation-evolution controversy in the United States. He authored 40 Days and 40 Nights: Darwin, Intelligent Design, God, Oxycontin, and Other Oddities on Trial in Pennsylvania, which focuses on the dissention surrounding the Kitzmiller v. Dover Area School District trial.
Since 1993, Adam has concentrated on the special-effects industry, honing his skills through more than 100 television commercials and a dozen feature films, including Star Wars Episode I: The Phantom Menace and Episode II: Attack of the Clones and currently co-host of Discovery Channel's MythBusters.
PZ Myers is a biology professor at the University of Minnesota, Morris. He is an outspoken critic of intelligent design, and is an activist in the creation-evolution debate. Myers maintains the blog Pharyngula, where he writes on creationism, biology, evolution, and scientific development. In 2005, Pharyngula won the Koufax Award for Best Expert Blog, which Nature describes at the top-ranked blog written by a scientist.
Christopher Hitchens is an author, journalist, and literary critic, and was a columnist for Vanity Fair. He is a political activist, outspoken atheist, and authored the bestselling book God is Not Great, which was nominated for a National Book Award.
For over a decade, Professor Wiseman has worked with the media to help bring science and psychology to a wide and diverse audience. His research has been featured in a large number of television programmes, including Horizon, Body Shock, 20/20, and Dateline.
Ever at the ready to uncover more "Bullshit!" from their hot Showtime series, will update us on their latest adventures.
Dr. Steven Novella is the Director of General Neurology at Yale University School of Medicine, President of the New England Skeptic's Society, host of The Skeptic's Guide to the Universe, and is a contributing editor for Quackwatch, a blog that uncovers unethical medical practices.
There are many more presenters then the ones you see above. Also scheduled to attend are: Phil Plait (The Bad Astronomer), Sharon Begley, Greydon Square (hiphop artist), George Hrab, Dr. Art Benjamin, Benjamin Radford, Banacheck, Paul Provenza and Richard Saunders. For full list with bio information visit the TAM 6 presenters page here
Workshop: The Real X-Files: Scientific Paranormal Investigations w/ Ben Radford Ever wondered how a person goes about investigating a haunted house, a Bigfoot sighting, or a crop circle? In movies and on television it looks easy, but how do real-life paranormal investigators discover what really happened, separating truth from myth? (Hint: Ghost Hunters ain't it!)
Come find out in a unique, two-hour intensive workshop taught by CSI investigator Benjamin Radford. Radford is managing editor of Skeptical Inquirer magazine, columnist for LiveScience.com, and author of three books and hundreds of articles on science literacy, investigation, and the paranormal. He will share his experience and insights gained over a decade of first-hand field investigations of mysterious phenomena. Drawing from dozens of case studies involving lake monsters, psychics, and ghosts, Ben will explain the step-by-step process in investigations, including critical thinking, evaluating unusual claims, interviewing eyewitnesses, and conducting field experiments.
Workshop: Mneumonic w/ Banacheck "Learn memory techniques from master mentalist Banachek when for the first time at TAM he shares some of his secrets with workshop participants. What may seem impossible now becomes possible when Banachek shows you how."
Show: Mathemagic w/ Dr. Art Benjamin Dr. Arthur Benjamin is both a professor of mathematics and a magician. He has combined his two loves to create a dynamic presentation called "Mathemagics," suitable for all audiences, where he demonstrates and explains his secrets for performing rapid mental calculations faster than a calculator. Reader's Digest calls him "America's Best Math Whiz". He has presented his high energy talk on over a thousand occasions to audiences throughout the world. Dr. Benjamin has appeared on many television and radio programs, including: The Today Show, CNN, Amazing Discoveries! and National Public Radio. He has been profiled in The New York Times, Los Angeles Times, USA Today, Scientific American, Discover Magazine, Omni Magazine, Esquire Magazine, People Magazine, and Reader's Digest.


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|Episode Description
|Friday, Sep 21, 2012 - 7:30 AM
"Out of Rome"
We leave the eternal city behind by way of the famous Appian Way to explore the environs of Rome. First it's the majesty of Emperor Hadrian's villa and the wine and lakes of the Alban Hills. Next, it's south to the ancient seaport of Ostia, Rome's Pompeii. D
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subset: commoncrawl


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Indiana in the Spanish-American War - Timeline
* Entries in Italics indicate Indiana connection.
George Eastman introduces the Kodak, a square box camera using roll film, making photography practical for the first time (Carruth, 349).
November 6
Republican Benjamin Harrison of Indiana is elected president of the United States (Carruth, 348).
Singer Manufacturing Company of Elizabethport, New Jersey, produces and markets the first electric sewing machine known in the U.S. (Carruth, 351).
April 22
The great Oklahoma land rush begins at noon; thousands of settlers race to stake a claim (Carruth, 350).
First May Day celebration is held in Paris (Grun, 445).
May 31
Flood kills 2295 persons when dam on Conemaugh River above Johnstown, Pennsylvania, breaks due to heavy rain (Carruth, 352).
Census shows U.S. population of 62,947,714; the center of population is placed 20 miles east of Columbus, Indiana (Carruth, 354).
Idaho and Wyoming are admitted to the Union as the 43rd and 44th states (Carruth, 354).
December 15
Sitting Bull, chief of the Sioux Indians, is killed by Red Tomahawk in a skirmish with Indian Agency police in South Dakota (Carruth, 356).
James Naismith, a physical education instructor in Springfield, Massachusetts, invents the game of basketball (Carruth, 357).
August 24
Thomas A. Edison files the first patent for a motion picture camera (Carruth, 359).
January 1
Ellis Island in upper New York Bay becomes the receiving station for immigrants (Carruth, 360).
November 8
Democrat Grover Cleveland is elected president of the U.S. (Carruth, 362).
Natural gas found in Indiana provides power for an estimated 300 new factories (Phillips, 194).
January 17
Queen Liliuokalani of Hawaii is deposed by a revolution. American Sanford Dole, protected by U.S. Marines, heads a provisional government, which is ended on April 13 (Carruth, 362, 364).
Worldwide financial panic and economic depression begin (Carruth, 363).
May 1
World's Columbian Exposition officially opens in Chicago, Illinois (Carruth, 363).
Indiana Department of Statistics estimates average annual wage of miners in Indiana at $287 (Phillips, 326).
Indiana National Guard units, including 2 black companies, are called by Governor Claude Matthews to calm striking coal miners in Sullivan County (Gatewood, 118, 118n).
April 20
136,000 U.S coal miners strike for higher wages (Carruth, 367).
May 11
Strike at the Pullman railroad car plant in south Chicago begins; a general railway strike by the American Railway Union, headed by Eugene V. Debs of Indiana, follows (Carruth, 369).
June 28
U.S. congressional resolution makes Labor Day a legal holiday (Carruth, 369).
August 8
Hawaiian Republic is officially recognized by the U.S. government (Carruth, 368).
September 4
12,000 garment workers strike in New York City protesting sweatshop conditions and piecework wages (Carruth, 369).
U.S. and Great Britain come close to war over 80-year-old boundary dispute between Venezuela and British Guiana (Carruth, 370).
Indiana General Assembly authorizes the reorganization and reequipping of the Indiana National Guard (Phillips, 63, 64).
February 24
Cuban revolt against Spain breaks out (Carruth, 370).
Swedish philanthropist Alfred Nobel dies; Nobel prizes are established for those who have benefitted mankind in physics, physiology and medicine, chemistry, literature, and peace (Grun, 450, 451).
Governor Matthews removes the 2 black companies from the Indiana National Guard and designates them as "separate" companies A and B (Gatewood, 118).
April 23
First moving pictures on a public screen are shown in New York City (Carruth, 374).
June 4
Assembly of the first Ford automobile is completed in Detroit, Michigan by Henry Ford and associates (Carruth, 375).
October 1
Rural free postal delivery is established in West Virginia (Carruth, 374).
First U.S. ice hockey league is formed in New York City (Carruth, 375, 376).
November 3
Republican James A. Mount is elected governor of Indiana (Phillips, 51).
November 3
Republican William McKinley is elected president of the U.S. (Carruth, 374).
Indiana General Assembly passes labor law prohibiting children under the age of 14 from working in manufacturing; no one under 16 or no woman under 18 is allowed to work more than 10 hours a day or 60 hours a week (Phillips, 332-333).
Indiana General Assembly passes law making it mandatory for all children between ages of 8 and 14 to attend school (Phillips, 389).
April 19
First Boston Marathon is won by John J. McDermott of New York City in 2 hours, 55 minutes, 10 seconds (Carruth, 377).
May 24
U.S. Congress appropriates $50,000 for relief of Americans in Cuba. Later in the year, Spain releases Americans imprisoned in Cuba (Carruth, 376).
July 2
Coal miners' strike shuts down mines in Pennsylvania, Ohio, and West Virginia (Carruth, 377).
January 25 Battleship U.S.S. Maine arrives at Havana, Cuba (Carruth, 378).
February 9
Letter written by Spanish minister to U.S., stolen and published in New York Journal, calls U.S. President McKinley weak and questions his honesty (Carruth, 378).
February 15
U.S.S. Maine explodes in Havana harbor; 260 officers and crewmen are killed. Cause of explosion is not known (Carruth, 378).
April 11
U.S. President McKinley requests authorization from Congress to use armed force to end the civil war in Cuba (Carruth, 378).
April 19
U.S. Congress adopts joint resolution authorizing President McKinley to use military force in Cuba and demanding Spain's withdrawal from the island (Carruth, 378).
April 22
President McKinley orders a blockade of Cuban ports; Rear Admiral William T. Sampson sails from Key West, Florida with a large fleet (Carruth, 378).
April 22
Congress passes Volunteer Army Act authorizing the organization of the First Volunteer Cavalry, known as the Rough Riders, commanded by Colonel Leonard Wood and Lieutenant Colonel Theodore Roosevelt (Carruth, 378, 380).
April 23
U.S. President McKinley calls for 125,000 volunteers to fight in war with Spain (Carruth, 380).
April 24
Spain declares war on the U.S. (Carruth, 380). 1898 April 25 U.S. Congress passes declaration of war against Spain effective April 21 (Carruth, 380).
April 25
U.S. Congress passes declaration of war against Spain effective April 21 (Carruth, 380).
April 25
Black leaders in Indiana begin movement to recruit an "independent colored regiment" whose services will be offered to Governor James Mount (Gatewood, 121-22).
May 1
In the Philippines, Commodore George Dewey commanding a six-ship squadron, destroys a larger Spanish fleet with only 8 U.S. wounded (Carruth, 380).
May 24
Battleship U.S.S. Oregon reaches Key West, Florida after 67-day voyage from San Francisco, California. Need for a canal across Panama is demonstrated (Carruth, 381).
May 25
President McKinley issues a second troop call, this time for 75,000 volunteers (Carruth, 380).
May 26
Governor Mount telegraphs U.S. Secretary of War Russell A. Alger requesting acceptance of Indiana's black regiment with black officers in addition to Indiana's quota under the second call for volunteers (Gatewood, 123, 123n).
May 27
Secretary Alger sends telegram to Governor Mount denying the request for the black regiment (Gatewood, 123).
May 28
Governor Mount sends request to Secretary Alger via Indiana Senator Charles W. Fairbanks asking to add to Indiana's quota a black battalion which could be attached to one of the "immune" regiments recruited by the U.S. War Department (Gatewood, 125).
June 6
Upon receiving an unfavorable response concerning Indiana's offer of a black battalion, Governor Mount and Senator Fairbanks appeal directly to President McKinley (Gatewood, 126,127).
June 8
Governor Mount receives word from U.S. Adjutant General Henry C. Corbin that War Department regulations have been modified so that black companies can keep black captains (Gatewood, 127, 127n).
June 12
17,000 U.S. forces leave Key West, Florida under General William R. Shafter, to capture Santiago de Cuba, Spain's largest naval base in Cuba (Carruth, 380).
June 21
Governor Mount is informed that Indiana's quota of soldier volunteers includes 1 regiment and 2 black companies (Gatewood, 128).
June 24
U.S. troops win first major land battle against Spain at Las Guasimas, Cuba (Carruth, 380).
July 1
U.S. troops, including the Rough Riders, take over San Juan Heights and El Caney, Cuba with heavy casualties on both sides (Carruth, 382).
July 3
U.S. ships destroy the Spanish fleet attempting to break the blockade at Santiago (Carruth, 382).
July 7
President McKinley signs legislation annexing the Hawaiian Islands (Carruth, 380).
July 8
Forces under Admiral Dewey occupy Isla Grande in Subic Bay near Manila, Philippines (Carruth, 382).
July 15
Indiana's 2 black companies, A and B, are mustered into the U.S. volunteer service at Camp Mount in Indianapolis (Gatewood, 130).
July 17
General José Toral and 24,000 Spanish troops surrender to U.S. General Shafter at Santiago de Cuba (Carruth, 382).
July 25
U.S. forces invade Puerto Rico with little resistance (Carruth, 382).
July 28
Ponce, Puerto Rico's second largest city, surrenders to Americans (Carruth, 382).
August 7
Rough Riders and other U.S. forces leave Cuba to escape epidemics (Carruth, 382).
August 9
U.S. force defeats Spanish force at Coamo, Puerto Rico (Carruth, 382).
August 12
U.S. war with Spain ceases; Spain agrees to give Cuba its independence and to cede Puerto Rico and Guam to U.S. The status of the Philippines will be discussed later (Carruth, 382).
September 2
Indiana's black companies leave Camp Mount for Ft. Thomas, Kentucky, where they are to be attached to the 8th Infantry, a black immune regiment (Gatewood, 132).
Indiana black companies and 8th Infantry move to Chickamauga Park, Georgia (Gatewood, 133).
November 8
Republican Theodore Roosevelt is elected governor of New York (Carruth, 382, 384).
December 10
Treaty ending Spanish-American War is signed in Paris (Carruth, 384).
Slaughtering and meat packing is the largest industry in Indiana (Phillips, 280).
January 20
Indiana black companies leave Chickamauga Park to return to Indianapolis (Gatewood, 137).
January 28
Indianapolis Recorder reports the celebration of the return of Indiana's black companies with a banquet by Indiana Soldiers' Aid Society at Bethel AME Church in Indianapolis (Gatewood, 138).
February 4
Philippine guerrillas fire on U.S. forces at Manila marking the beginning of rebellion for independence (Carruth, 384).
February 10
President McKinley signs peace treaty with Spain; Cuba gains independence, U.S. gains Puerto Rico, Guam, and, for $20,000,000, Spanish holdings in the Philippines (Carruth, 384).
U.S. cigarette production reaches 4,000,000,000 gaining on cigars, pipes, and chewing tobacco in popularity (Carruth, 389).
Ball Brothers Co. of Muncie is largest producer of glass canning jars in the U.S. (Phillips, 297-298).
April 30
U.S. Congress passes act establishing the Territory of Hawaii; Sanford B. Dole is appointed first governor (Carruth, 388).
June 21
U.S. military governor of the Philippines, General Arthur MacArthur grants amnesty to Filipino rebels (Carruth, 388).
November 6
Republican Winfield T. Durbin, commanding officer of the 161st Indiana Volunteers in the Spanish-American War, is elected governor of Indiana (Phillips, 75).
November 6
William McKinley is reelected president of the U.S. and New York governor Theodore Roosevelt is elected vice president (Carruth, 388).
Queen Victoria of England dies; her son Edward VII becomes king (Grun, 454).
January 10
First great oil strike in Texas gushes in on the Spindletop claim near Beaumont, Texas (Carruth, 393).
February 2
Army Nurse Corps is organized as a branch of the U.S. Army (Carruth, 390).
April 19
The rebellion in the Philippines is ended by proclamation (Carruth, 392).
September 6
President McKinley is shot and dies September 14 (Carruth, 390).
September 14
Theodore Roosevelt is sworn in as 26th president of the U.S. (Carruth, 390).
June 28
U.S. Congress passes Isthmian Canal Act which authorizes and finances construction of a canal across the Isthmus of Panama (Carruth, 394).
July 1
U.S. Congress passes Philippine Government Act declaring Philippine Islands an unorganized territory and authorizing a commission to govern the territory (Carruth, 394).
July 4
First Pacific communications cable is opened; President Roosevelt sends message around the world and back to him in 12 minutes (Carruth, 397).
October 1
First baseball World Series begins between the Pittsburgh Pirates and the Boston Red Stockings; Boston wins (Carruth, 395).
December 17
Orville Wright makes first powered flight in a heavier-than-air machine at Kitty Hawk, North Carolina (Carruth, 395).
Russo-Japanese War begins (Grun, 456).
May 5
Eugene V. Debs of Indiana is nominated for the presidency of the U.S. by the Socialist National Convention (Carruth, 398).
November 8
Theodore Roosevelt is elected president of the U.S; Charles Fairbanks of Indiana is elected vice president (Carruth, 398).
United States Steel Corporation begins construction of world's largest steel furnace and mill in northwestern Indiana; the company lays out the new town of Gary (Phillips, 309).
August 23
First president of Cuba, Tomás Estrada Palma, requests U.S. intervention to stop a revolt arising from election disputes; President Roosevelt finally sends troops in October who take over government for 13 days (Carruth, 404).
January 26
U.S. Congress passes a law prohibiting corporate campaign contributions to candidates for national office (Carruth, 404).
September 12
Lusitania, the largest steamship in the world, arrives in New York City on its maiden voyage setting a new speed record of 5 days, 54 minutes between Queenstown (now Cobh), Ireland and New York (Carruth, 407).
National Association for the Advancement of Colored People is founded in the U.S. to promote the rights and welfare of black Americans (Carruth, 412).
Albion Fellows Bacon of Evansville successfully lobbies the Indiana General Assembly to pass the state's first comprehensive housing law (Phillips, 487).
Madam C. J. Walker, black woman from Louisiana, establishes a company in Indianapolis to manufacture hair treatments and cosmetics (Phillips, 291-292).
May 18
Halley's comet passes close enough to earth for its tail to be seen across much of night sky; some people fear the end of the world (Carruth, 415).


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Categories: Business, Corporate, Commercial Law
Instructor(s) Heymann, S. Richard
Business transactions constitute one of the more important aspects of business law. This course is intended to enable students who contemplate a career in business law to become familiar with the elements of basic business transactions and the legal issues they present to the lawyers who handle them. During the fall semester (Fundamentals of Bus. Trans. I) we will begin to study the characteristics of certain basic transactions and some of the more common issues they often present. (Fundamentals of Bus. Trans. II in the spring term will complete our analysis and proceed to apply what we have covered in the first part of the course to a sample transaction.) While this is not a "skills course," we will also address certain basic negotiation and drafting issues inherent in business transactions. 3L status and Bus. Orgs. I are pre-requisites.


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Students from The Newtown Music Project and folk singer Ingrid Michaelson have recorded a rendition of "Somewhere Over the Rainbow" in support for – and solidarity with – the students of Sandy Hook Elementary School. One month after the horrific school shooting in Newtown, Conn., the children and Michaleson have come together to help those affected by the tragedy: The song, which they performed on Good Morning America today, is available for download on Amazon and iTunes, with all proceeds going to the Newtown Youth Academy and the United Way of Western Connecticut.
Sabrina Post, a Newtown music teacher, told Good Morning America: "So many of the students came to me, and all I could see in their eyes... is 'How can we help?'" When banners and ribbons weren't enough, the students channeled their feelings into song. One student told GMA: "I hope that someday our world will be peaceful and loving, no violence at all."
The lyrics of "Somewhere Over the Rainbow," perhaps best known via the film "The Wizard of Oz," express the children's message beautifully:
Somewhere over the rainbow, skies are blue
And the dreams that you dare to dream really do come true.
Michaelson and the students aren't the first to respond to the Newtown tragedy through music, and they probably won't be the last. Still, we'll be listening to this heartfelt song on repeat all day long. Tell us what songs get you through difficult times in the comments.


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Mega Build 2012
Members of the Carlson School community recently gathered for the first-ever Mega Build, a day of service devoted to help build at Habitat for Humanity sites around the Twin Cities.
More than 70 Carlson School members ditched the dress shoes and slipped on the work boots for the school's first-ever Mega Build, a service event held March 30 that brought together the Carlson School community to help build at Habitat for Humanity sites around the Twin Cities.
"I love this. It's been a lot of fun," says freshman Niandra Theiss with a smear of white paint prominently displayed on her face. "You get to see the work you've done and you're actually doing something productive and you're actually helping."
How much they were helping, explains Marysa Lai, senior and co-coordinator of the Mega Build, was driven home by a game that was played with her group during a break.
"We learned a lot about homelessness and how it affects people," she says, adding that the game taught them that "it takes more money to put someone up in a shelter than it does to put them into an apartment, which is crazy to think about."
Building the Framework
"Marysa and I decided this would be a great opportunity to have a Carlson community service event and be able to incorporate our U of M chapter of Habitat," says Mega Build Co-Coordinator Resman. "We started brainstorming back in the fall, in October, and then got a committee after Christmas and now we're here."
"This has just been amazing," she says. "It's been phenomenal to see that we were able to get over 70 people sign up and come to this event and see how much people care for the community and want to give back and contribute and have a positive impact overall. So, it's been awesome."
60K Day. A One Day Fundraiser on April 12
Building on the momentum of the Mega Build, the Carlson School undergraduate student body has pledged to raise $5,000 on 60K Day, the one day, University of Minnesota community driven, charity event to raise $60,000 to sponsor a Habitat for Humanity home. Donations will be used to help build a home in S. Minneapolis for Habitat family Kadra Musse and Noor Ahmed and their children.
"The ultimate goal is really to connect the entire University to come together for one common goal, on one day," says Resman.
Other University student organizations, individuals, colleges, faculty, and staff have already committed to contributing toward the cause. To pledge and for more information on 60K Day, visit 60kday.org.


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From Brexit to Making Tax Digital, our sector specialists will guide you through the specific issues that are affecting organisations in your industry. We understand the challenges that you face.
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We have many office locations across the UK, please view our locations and get in touch with your local contact.


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Rawplug SDS Plus masonry drill bit provide maximum power transmission due to the unique fluted shank design. The tip is made from Tungsten Carbide to provide excellent drilling performance.
To be used only in machines with an SDS-Plus quick release chuck.
Size. 15 mm x 160 mm.
All Prices Shown are Inclusive of VAT


text: North County is home to the Boeing Company's Defense, Space and Security sectors for business, engineering and manufacturing as well as Lambert Airport, and the world headquarters for Express Scripts. The area is a leader in manufacturing employment with the largest concentration of industrial and warehouse space in the metro area. Business Parks and the Riverport area together comprise one of the largest commercial clusters in the county boasting an annual payroll of over $8.1 billion. The area is home to a very diverse population with cultural and socioeconomic factors contributing to vibrant and growing neighborhoods that include Bridgeton, Ferguson, Florissant, Hazelwood, Jennings, Maryland Heights and more.


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"The casting director is on the actor's side, both selfishly and unselfishly," says CD David Caparelliotis. "Selfishly, because I have to get my job done. I don't want to have 20 actors come in and be terrible, so I don't have anyone to bring to the director the next day. I'm only as good as the people I can bring in."
Caparelliotis has become one of New York's most successful casting directors by consistently finding the right actors for Broadway, Off-Broadway, and regional theater productions. He won an Artios Award last year for casting "Good People," starring Frances McDormand and Tate Donovan, and was nominated for three Artios Awards in 2010, for his work on "Fences," "The Royal Family," and "Lend Me a Tenor."
Prior to opening his casting office, MelCap Casting, with fellow CD Mele Nagler in the fall of 2007, Caparelliotis was a casting director for Manhattan Theatre Club for a decade. He continues to cast two to three shows for MTC each year as a casting consultant.
But Caparelliotis' newest challenge is something of a first. He is casting rappers for an upcoming three-week developmental workshop of "Holler If Ya Hear Me," a new musical inspired by and featuring the music of the late hip-hop icon Tupac Shakur. If the project ends up on the Great White Way, it will be the first full-scale hip-hop production in Broadway history.
"I didn't know anything about the subject matter," Caparelliotis says, "but the minute I started reading it I was completely intrigued and interested, and I could imagine myself being immersed in this world for three or four months." When he listened to Tupac's music for the first time, the self-described "square white guy" became a fan: "For 'Holler If Ya Hear Me,' I'm going to be sitting and watching actors come in and do freestyle rap. I can think of nothing more exciting than that."
At first Caparelliotis thought that acting was his passion. He studied theater and psychology at Sarah Lawrence College, then pursued an acting career by waiting tables and performing in Off-Off-Broadway productions. After a few years, though, he felt trapped. When he did not get cast as an understudy in a certain production, he says, "I was not disappointed in the way that I should have been. They say if there's anything else you can do besides acting, try it."
He began working as an intern with casting director Nancy Piccione at Manhattan Theatre Club, where he was eventually hired as a casting associate and later promoted to casting director.
Manhattan Theatre Club gave Caparelliotis many of the tools he would need to continue his climb. He met Nagler when both were interns at the company, then hired her as assistant to himself and Piccione a few years later. At the same time, Caparelliotis was developing relationships with writers, directors, and producers such as A.R. Gurney and Scott Rudin.
"Enough people knew me that it didn't seem like I was completely out of my mind to leave and start my own company," he says. Lynne Meadow, MTC's artistic director, offered the theater as their first client. Rudin has been a returning customer, as well. MelCap cast his production of "Death of a Salesman," which is on Broadway this season with direction by Mike Nichols.
MelCap's many other current projects include Paul Weitz's forthcoming "Lonely, I'm Not" for Second Stage Theatre, David Auburn's new play "The Columnist" for MTC, and "Seminar," for which Caparelliotis recently hired cast replacements Jeff Goldblum, Justin Long, and Zoe Lister-Jones.
"I have a lot of satisfaction in my career, and I've had the opportunity to work with a lot of great people on a lot of great things," Caparelliotis says. "I actually feel like if I were to give it all up and go open up a cupcake shop on the Cape, I'd be fine. I have achieved wonderful things."
David Caparelliotis Brings Off-Broadway Aesthetic to Broadway Casting
"The casting director is on the actor's side, both selfishly and unselfishly," says CD David Caparelliotis. "Selfishly, because I have to get my job done. I don't want to have 20 actors come in and be terrible, so I don't have anyone to bring to the director the next day. I'm only as good as the people I can bring in."


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Plantation Style Mint Julep; Bubbles of fresh tasting mint in a soft drink. This one is so great! It's delicious alone, use it as a mixer or make ice cubes. [12 fl.oz/355 mL]
INGREDIENTS: Carbonated Water, Sugar, Flavor and Citric Acid.
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Galco's Soda Pop Stop cannot guarantee remembrance of flavor or carbonation levels. We are not a bottler and these factors are beyond our control.
Photo images on our web site may not reflect the actual product label or bottle.
Note to California residents: Prop. 65 warning: Some painted labels contain chemicals known to the state of California to cause cancer. WARNING: Many food and beverage cans have linings containing bisphenol A (BPA), a chemical known to the State of California to cause harm to the female reproductive system. Jar lids and bottle caps may also contain BPA. You can be exposed to BPA when you consume foods or beverages packaged in these containers. For more information go to: http://P65Warnings.ca.gov/BPA.


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Ayers et al v. Wyeth et al
Filing 10
ORDER finding that the amended and substituted complaint must be conventionally filed by 5:00 p.m. on 11/15/2010 or the case will be dismissed with prejudice. Signed by Judge William R. Wilson, Jr on 11/3/10. (bkp)
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.


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Ninety-four games have a charity button! Find out why.
This year, we are hosting all games at the One Game A Month community website.
In 2013 we made 94 games and in 2012 we made 77 games. Check them out!
There are ninety-four cartridges in our game library. Check them out.
Recently, over a hundred gamedevs around the world helped out by including links to charities in their games. In 2012 we also made games for good. Join us in November for the 3rd annual Charity Game Jam!


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A vinyl as a notebook, a notebook as a vinyl. Music, texts, illustrations and graphics come together, created by 20 different artists from around the world who specialize in practices as diverse as dance, film, electronic music, jazz, song-writing, poetry, illustration and visual art.
A Moleskine notebook, a 7" vinyl and an online repository form Canzoni Invisibili/Invisible Songs; a wide-reaching project conceived by Alessandro Cremonesi (La Crus) and Lagash (Marlene Kuntz) to celebrate the Italian writer Italo Calvino. 10 novels have been reimagined, taking his interdisciplinary and collaborative approach to heart through free interpretations and responses.
Music by Ellen Allien, Jeet Thayil, Lagash and Cremonesi is contained in a record held within the cover of the notebook - listen to the teaser track embedded above. With a special gold silkscreen and custom cut cover, the notebook becomes a record holder. Inside lie 60 pages filled with poems, illustrations, texts and artworks by illustrator Tamara Ferioli, artist Masbedo and ambient curator The Sight Below to name a few. All of them are brought together through the beautiful graphic direction of Thomas Gangnet. Thus the original ideas and interpretations of some of the most exciting creative minds active today are contained in audio and visual form.
[Left - Right: Ellen Allien | Masbedo | Lullatone]
Blank space is purposefully left among the pages for the continuation of free interpretations to facilitate an on-going creative dialogue that can then be submitted through the online portal. An open project, the online space acts as a construction site of ideas, interpretations and possible collaborations.
[Left - Right: Mari Kvien Brunvoll | Dodo Nkishi | Erna Omarsdottir]
Eroding traditional hierarchies of artistic practice, Canzoni Invisibili strives towards the creation of new hybrid artistic formations that live beyond the constraints of analog, digital, audio and visual.
Available on the Moleskine Store .
To learn more about Italo Calvino, check out our Pinterest gallery of his tales-turned-tweets and drawings on Moleskine notebooks from a project last year.
Full list of artists:
ERNA OMARSDOTTIR: Dancer and Choreographer, Reykjavik - Iceland
ELLEN ALLIEN: DJ, Musician and Label Manager, Berlin – Germany
JEET THAYIL: Poet, Novelist and Musician, New Delhi - India
MASBEDO: Video Artist, Milan - Italy
FRAN HEALY: Musician, Glasgow - Scotland
SILVIO MORAIS D'AMICO: Composer, Rio De Janeiro - Brazil
CLAUDIO SINATTI: Video Live Performer, Milan - Italy
LULLATONE: Pajama-pop Band, Nagoya - Japan
EUGENIO FINARDI: Songwriter and Singer, Milan - Italy
MARI KVIEN BRUNVOLL: Jazz vocals and Electronic, Molde - Norway
GIUSEPPE PICCIONI: Director, Rome - Italy
DODO NKISHI: Musician and Singer, Berlin - Germany
LEONARDO COLOMBATI: Writer, Rome - Italy
ERNA PACHULKE: Composer, Berlin - Germany
AD BOURKE: Electronic Musician, Rome - Italy
THE SIGHT BELOW: Ambient Artist & Curator, Seattle - USA
MARGOT SIKABONYI: Actress, Rome- Italy
TAMARA FERIOLI: Visual Artist, Milan - Italy
DRAFTSMEN'S CONGRESS: 7th Berlin Biennale for Contemporary Art, Berlin - Germany
ARIANNA VAIRO: Illustrator, Milan- Italy
THOMAS GANGNET: Graphic Concept, Paris – France
ALESSANDRO CREMONESI: Author, Milan – Italy
LAGASH: Musician and Producer, Milan – Italy


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Wednesday, February 4, 2009
A New Kiowa Linux On The Way!
Check out what Kiowa Linux has in store for us:
"Kiowa Linux final KDE 4 edition soon to be released featuring KDE 4.1 sleek stylish NEW look for Kiowa. A new Kiowa kernel with a much larger supported hardware list... Improved wifi and mini pc support... Improved support for ATI and NVidia drivers as well as easier installation and uninstall routines. An improved Kiowa installer that is easier to use and more complete. We are migrating from Apt to Yum for package management in this release. Along with Yum, we are releasing with KPackagekit, a more advanced DBUS driven package manager GUI to replace Synaptic. The reason for this move is to improve software installation/integration that is less resource intensive.
"Open Office 3, Gimp 2.6 and much much more."
I run Kiowa Linux on my laptop and it's a solid, sble and secure Linux distro. it's easy to use and has a real frinedly and welcoming feel to it. Once this new version of Kiowa is released, I'll be installing it on my laptop and my desktop!
I'll have more reports and updates on Kiowa Linux as they approach launch time and when I get it installed and up and running on my systems.
Get Linux.
3 comments:
- bunlacken said...
I have been using "Kiowa morningstar" but the repositories do not work, they delete the basic system and wipe the operation out... what's up?.
I cannot install it on my "HP tablet pc 1000" where I really want it.
I love the distro but both of these problems keep me away from steady use.
- April 20, 2009 at 3:55 PM
- MSzorady said...
I just got an email from Matt regarding Kiowa Linux. He writes, "Mark, Thanks for informing me about the questions regarding the next releases and the repo current state.
"we are aware of some of the current repo issues it's due to our large amount of changes to the editions the repo will be fixed by release time and will be much larger ;)
"If there are any more questions or comments let me know ill be glad to answer them for you! "
- April 26, 2009 at 3:34 PM
- bunlacken said...
Like you I love the distro.. and will continue to keep in touch... Morningstar also does not recognise an installed cd which can be a problem as I keep my desktop setup on a cd... I will wait on the latest coming down the pike rather than gripe too much even though I like the Gnome system.
- April 26, 2009 at 9:09 PM


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Suicide of William F. Holloway
I am researching my ex-mother-in-law's father who committed suicide between 1930 and 1940, I think. His name was William F. Holloway. Her mother's name was Nettie McCubbins. She was born in 1915 in Tipton County, IN. I am not sure where he was born but probably died in Tipton Co. or Howard Co., IN. Their daughter's name is Beverly Jane McCubbins.
Surnames: HOLLOWAYMCCUBBINS
Viewed: 1000 times


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Yesterday, I commented about an op-ed in which Martha Minow (dean of Harvard Law School) and Robert Post (dean of Yale Law School) defend their institutions' consideration of race in law school admissions decisions as a means of assessing the character of applicants. I argued that such an assessment smacks of racism, relies on the unverified stories of applicants about how race has affected their lives, and has nothing much to do with what colleges and universities actually do when they grant racial preferences.
A friend with vast experience in employment law offers an additional point. He focuses on the claim by Minow and Post that a rule forbidding all consideration of race by colleges, law schools, etc. could not possibly be enforced. They say:
Essays and letters of recommendation are critical components of the application process at law schools. They allow us to evaluate intangible virtues such as courage, commitment and moral compass. In their personal statements, many applicants discuss how race has influenced their lives. Writers of recommendations frequently mention race in explaining how an applicant has overcome challenges. Would those advocating race-blind admissions have us censor the statements of applicants and their recommenders? How could we carry out such a task, even if we were inclined to do so?
My friend responds with this helpful suggestion:
Plenty of employers are subject to Title VII and similar state and local laws, and they operate within a legal framework that requires them to make employment decisions without "consideration of race." Indeed, taxpayers annually pay several hundred million dollars to fund the EEOC with the idea – perhaps quaint, perhaps naive – that the EEOC will enforce race discrimination prohibitions in employment.
Given the enforcement difficulties identified by Deans Minow and Post, perhaps Congress could create a similar agency that would be responsible for policing admissions decisions by colleges and universities. With their help, Congress can probably come up with a catchy name for such an agency. How about the Equal Entrance Opportunities to Colleges Commission? The EEOCC has a nice sound, and given the lousy economy, the government would have no trouble staffing it with investigators and lawyers who could then demand that places like Harvard and Yale Law Schools be subject to lengthy, time-consuming and expensive investigations and litigation just like employers.
The academic hiring and tenure decisions of colleges and universities are subject to legal challenge by those who believe they have been discriminated against based on race, gender, etc. These claims may entail involve a tricky review of the qualilty of published work, the value of certain kinds of research, etc.
One would hope that external review isn't necessary when it comes to college admissions decisions. One would like to trust the administrators of law schools to make color blind decisions if they are told that this is what the Constitution requires. But if Minow and Post say they aren't capable of doing so, they would have only themselves to blame if a special agency were established to help them out.


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NOTES______________________from the UNDERGROUND No. 213 (& Poetry Dispatch) | April 9, 2012
Bob Edwards: A VOICE IN THE BOX
Editor's Note: "Radio Love" … I don't know what else to call it, this feeling. It attracted my attention as a young child…the kitchen radio on top the refrigerator where my father listened to the news…Gabriel Heatter: "There's good news tonight!" and Walter Winchell: "Good Evening Mr. and Mrs. America from border to border and coast to coast and all the ships at sea. Let's go to press." Talk about drama! That little wooden radio…which my mother tuned to an ethnic music station on Friday evening and sang along in Czech…where I listened to the Shadow, the Lone Ranger, Superman, etc. Where Arthur Godfrey was always on the air singing: "It Seems Like Old Times…" Where I first heard the news of the Japanese attack on Pearl Harbor.
And that large living room console where the three of us listened and laughed in the dark to Jack Benny, Fibber McGee and Molly, Amos and Andy, Fred Allen, and Bob Hope.
Those were the days, my friend…
Yes they were. And so they continue into the present, thanks to the gods of the airwaves who refuse to be silenced in our high-tech times. Television never did kill radio. Never will.
I must caution myself at this point from writing a full-blown piece on my radio love affairs. There's so much to remember. So much to praise. All those voices which resonate within me to this day.
I still see myself as a young boy in my bedroom…fiddling with a crystal set trying to bring in a station! That's how far back my initial love affair goes. Followed later in my Chicago life by a more gown-up, more cultural, in some ways more exciting new love affair with WFMT, the voice and passion of Studs Terkel, "The Midnight Special" every Saturday night…classical music, the knowledge and comforting voice my friend, Marty Robinson, brought to the airwaves. How thankful I remain today in Wisconsin, forty plus years later, for the role radio still plays in my life, 24 hours a day—tuned to Wisconsin Public Radio and NPR. How appreciative I am of one voice alone, the many hours of program pleasure and thought the recently retired Jean Feraca brought to us lucky to share her interview skills, her thought and laughter. (Scroll down.)
But let me introduce you to Bob Edwards–who needs no introduction if you listened to NPR faithfully and followed his voice past and present.
His book: A VOICE IN THE BOX, My Life in RADIO is a history, a memoir, a romance with radio—a testament to the beauty of communication that expands our minds and imagination by the simple art of lending an ear, listening in a way
one's life depended upon it. Which in some ways, it always has.
A few excerpts. The voice of Bob Edwards. Stay tuned… —Norbert Blei
November 6, 2004. Another cold, crisp night in the Windy City, but it's warm inside the Grand Ballroom of the Renaissance Chicago Hotel, where hundreds of radio royalty have gathered. Men in tuxedos and women in beautiful gowns or sexy cocktail dresses are clustered at thirty-four tables, each adorned with flowers and a burning candle. At one end of the ballroom is a bandstand, where Mickey and the Memories will entertain for everyone's dancing pleasure. That will come later, after dinner, many speeches, and a ceremony that is also a live radio program carried by the Premier group of stations.
The announcer is Jim Bohannon, one of my oldest friends in radio. He has alerted the diners to the Applause sign behind him and has let it be known that great audible enthusiasm is encouraged. At exactly 8:00 PM, we hear some upbeat theme music, and all respond to the sign's insistent demand for applause. A floor director cues Bohannon, who says, "Live, from Chicago, it's radio's biggest night—the 2004 Radio Hall of Fame induction ceremony. Tonight, the Radio Hall of Fame inducts XM Satellite Radio superstar Bob Edwards."
Superstar? We do love our hyperbole in radio. As of that night, my show on XM was just four weeks old. I doubt if the fellow who, months earlier, fired me from my previous show at NPR regarded me as anybody's superstar. But no matter—I was in the Hall.
Radio is closing in on its centennial, and its Hall of Fame includes the scientists who invented it, the hucksters who made money from it, the journalists who informed, the smart people who enlightened, and especially the enormously talented entertainers who came into our homes and cars and offices and made us laugh, cry, wince, fear, dread, guffaw, and enter worlds we could not imagine on our own. So here I am with Marconi, Edward R. Murrow, Arthur Godfrey, Alan Freed, Fibber McGee and Molly, Amos 'n' Andy, Orson Welles, Paul Harvey, Wolfman Jack, Bing Crosby, Gordon McLendon, Studs Terkel, Ma Perkins. Cousin Brucie, Red Barber, the Lone Ranger—just a stew of people, programs, and genres spanning generations and having nothing in common but the microphone and an audience.
My induction ceremony was a watershed event—the last in a series of traumas and triumphs that had kept me in a state of emotional whiplash for most of the year. So this night in Chicago was the end of something but also the beginning of something. It symbolized my passage to a new radio home and an environment in which I could do what I regard as the very best work of my career.
Induction really recognizes a much longer journey—the span of a career. So let's go back to the little burg where my radio journey began in 1968, when I had no notion of a hall of fame—only a burning desire to be a voice in the box.
…As the ABC anchor cued the station break, I flipped the switch and spoke the first words of my broadcast career: "This is WHEL, 1570, in New Albany, Indiana."
There were no fireworks in celebration and my debut escaped the notice of the local newspapers, but there's nothing bigger in a young man's life than realizing his dream. Never mind that I was working at the tackiest, most miserable little outpost in American broadcasting; I had crossed the threshold and joined the profession of Edward R. Murrow, Arthur Godfrey, and Red Barber.
Why wouldn't I be thrilled at joining the club? For nearly fifty years, broadcasters had informed and entertained Americans in ways that newspapers, magazines, theater, and motion pictures could not. They had made it possible for citizens to feel present at events occurring far away. Murrow's rooftop broadcasts during the London Blitz brought World War II into the living rooms of Manhattan apartments and Iowa farmhouses. Earlier, people short on hope during the Great Depression heard reassuring words from their president on the radio, and radio performers offered the only professional entertainment most Americans could afford. Baseball fans no longer had to gather at the local newspaper office to be relayed telegraph reports of the World Series. Graham McNamee in the twenties and Red Barber in the thirties magically transported fans in the bayous and the Rockies to the ballparks of New York, Chicago, and Detroit. Arthur Godfrey, on radio and then on television, brought a folksy personality to the airwaves and made his audience comfortable with the entertainers he introduced.
Little boys want to be firefighters or athletes or rock stars. I wanted to be on the radio. The radio in our house was a handsome mahogany Zenith purchased by my parents when they married in 1939, Now decorating my living room, the Zenith Long Distance Radio remains a marvel to me. It's more than three-and-a-half feet high, more than two feet wide, and a foot and a half deep. It doubles as a piece of furniture, the perfect pedestal for flowers in a vase next to a framed portrait of Grandma. As a toddler, I ran my fingernails across the fabric covering the huge speaker at the base. Reaching high and to the left, I could touch the knobs and buttons (voice, normal, treble, alto, bass). To the right were the push buttons labeled with the call letters of stations that don't exist today. Frequencies were listed in clock-face fashion, shortwave stations forming the upper arc, the AM band on the lower arc. At "noon" on the clock face and out of my reach was the mysterious green light that peered at all in the room.
With a tall outside antenna, our radio could pick up foreign broadcasts, ships at sea, police calls, and ham operators, but we didn't bother with that. We listened to the network programs that had yet to make the switch to television. Soap operas were still on the radio; Our Gal Sunday and The Romance of Helen Trent were my grandmother's favorites. I remember hearing President Truman talk about the war in Korea, Just before suppertime, a local priest would lead the rosary and Mom would insist that I pray along.
So many voices coming out of that box fascinated me. It didn't matter what the voices were saying; I longed for mine to join them. In time, I learned the formats of all the local stations and knew the schedules of all the announcers. At night, I heard other voices on stations in Chicago, Nashville, New Orleans, and Cincinnati, and I'd dream of seeing those places someday. Everything said on the radio had my attention in those days, not just the news. I would have been perfectly content to be the fellow who said, "You're listening to the music of…" or "Tune in tomorrow for another thrilling adventure of…." I just wanted to be one of the voices in the box.
[from: A VOICE IN THE BOX, My Life in Radio, the University Press of Kentucky, 2011]


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Alumni Benefits
Alumni Email Account
Philadelphia University has partnered with Microsoft to offer lifetime alumni email accounts @alumni.PhilaU.edu. Fill out the Alumni Email Address form to apply.
Career Services
Philadelphia University alumni can take advantage of the many resources and services of the Career Services Center including CareerLink - an online job database. Alumni are also welcome and encouraged to post company internship and employment opportunities to the database.
Diploma Replacement
Complete this form to replace a lost or destroyed diploma or to update from a PTI/PCT&S to a Philadelphia University diploma.
Library Services
If you wish to gain entry to the building and exercise book borrowing privileges, please contact the Office of Development and Alumni Relations to request an alumni card. The university's online databases are not available to alumni. We are unable to provide general access to computers, the Internet, or software applications. There is a computer at the Reference Desk reserved for anyone who wants to search the library catalog. Click here for more information.
Complete this form if you require official or unofficial transcripts for employment or graduate studies.
Partnership Programs
- Home and Auto (Discount) Insurance from Liberty Mutual
As a Philadelphia University alumnus, you qualify for a special group discount on your auto, home, and renters insurance through Group Savings Plus from Liberty Mutual. With Group Savings Plus, you can enjoy the ease and convenience of paying your premiums through checking account deductions with no down payment or finance charges. You'll also enjoy fast, easy round-the-clock claims service and a variety of discounts including multi-car, multi-policy, safe-driver, passive restraints and anti-theft device discounts. See for yourself how much you could save with Liberty Mutual compared to your current insurance provider. To learn more and to receive a free, no-obligation quote call Andrew Amaro (215) 345-4422 ext. 50916 or call Jeff Gallo (215) 579-3922 ext. 52965.
Visit www.libertymutual.com/PhilaU.
- Becker FastPass CPA Review Course Discount
Philadelphia University has partnered with Becker Professional Education to bring the FastPass accelerated CPA review program to campus beginning June 2011. Through the partnership, PhilaU alumni receive a substantial discount ($400) off the cost of the FastPass program. Alumni currently enrolled in a Philadelphia University program will also receive an additional $200 savings. To learn more about the Becker CPA Review FastPass or to enroll, please contact Jackie Plasky at firstname.lastname@example.com or 856.313.4125 and visit www.becker.com.
- The FastPass offer is an offshoot of PhilaU's exciting new MBA-CPA program. For more information on this accelerated program, please visit www.PhilaU.edu/MBACPA
- Philadelphia University License Plate (Pennsylvania residents only)
Click here to show your pride with a PennDOT approved PhilaU license plate. Available for passenger vehicles, trucks and motor homes.
- 1800Flowers.com & 1800Baskets.com offer
For more than 30 years, 1-800-FLOWERS.COM Inc. has been providing customers around the world with the freshest flowers and finest selection of plants, gift baskets, gourmet foods, confections and plush stuffed animals perfect for every occasion.
To place an order and receive your 15% discount, visit www.1800flowers.com and use promotion code "PHU" at checkout or call (800) 356-9377 and mention promotion code PHU.
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NEW UPDATE: Hmm, this is a situation, isn't it. Well, MTV press person Lina Schade says no decision has been made that the show will have a second season, let alone where it might end up. She's shooting down any Sea Isle speculation, at least for now. Mayor Len Desiderio says he and his town want no part of Snooki et al. "It's not a good fit," he said. Not sure I totally agree with that, Mayor Len.
Rumors are flying that MTV's Jersey Shore, which finishes up its legendary tear through Seaside Heights with its season finale tonight, leaving only a court hearing on a stray assault charge in its wake, will land further down the shore next season, taking up residence in byootiful Sea Isle City. Awesome. Should be a fine time all around, what with all of Philly showing up for no-beach-tag Wednesdays. And this could be huge for our favorite Jersey Shore cover band, Mr. Greengenes, which already has most Fridays booked to be at the Ocean Drive at 40th and Landis. Snookie should fit right in at the O.D. and totally dig Mr. Greengenes lead singer, Bryen, who lists his pet peeves as girls who ask for free stuff without flashing him. Meanwhile Sammi Sweetheart and Ronni will be on hand at McFaddens on North Third Street in Philly for Jersey Shore night tomorrow (Friday), with promises of bikinis and blowouts, guido's and guidettes. And, just for fun, Lindsey Lohan's dad.
UPDATE: This morning, Patti Ponichtera in Sea Isle Mayor Len Desiderio's office says the rumors are not true, or at least nobody from MTV asked them for permission. And, furthermore, she said lovely Sea Isle City wants nothing to do with Snooki and her gang. "We spend a lot of time and money to promote this as a family town," she said. She said business owners, including the bar owners in town, were calling and e-mailing all morning to voice their objections to having anything to do with the Jersey Shore gang. Aww, come on, people! This would have been awesome. Mayor Len, meanwhile, was on his way into the office to put out the rumor fire. There was no word back from MTV in any case. To be continued.


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Photographs (by George P. Landow) You may use these images without prior permission for any scholarly or educational purpose as long as you (1) credit the photographer and (2) link your document to this URL in a web document or cite the Victorian Web in a print one. Click on images to enlarge them.
The southern end
Looking toward the North Gate of the Schwedagon Pagoda. Yangon, Burma [Myanmar]. November 2000.
Worshippers at one of the small central shrines.
Left: Detail of the central stupa.
Left to right: Two monks, a guardian spirit, and the northern entrance.
Last modified 17 April 2001


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Another April Snow Storm Targeting the Duluth / Superior Area and Northland to Start Next Week
If you haven't had enough of the late-season snow, there is another round heading toward the Twin Ports and Northland for the end of the weekend.The National Weather Service is forecasting another major winter storm that will hit the region Sunday and into Monday. This storm has led to an issue of a winter storm warning for the entire Twin Ports region in effect from 1 pm Sunday to 7 am Monday.
As of the latest forecast, the immediate Twin Ports and portions of the Iron Range and North Shore could see 4-8 inches of snowfall, with the heaviest snow expected late Sunday afternoon and early Sunday evening. While there is a chance of mixed precipitation in those areas, there is a greater likelihood of mixed precipitation in Northwestern Wisconsin and East Central Minnesota, including areas as far north as Moose Lake.
Gusty east winds between 15 and 25 mph off Lake Superior will lead to blowing and drifting snow, and could lead to some lake enhancement, offering slightly higher amounts of snow along the North Shore and into the Twin Ports. At the peak of the storm, snow could fall at or above a rate of one inch per hour and travel will likely be very difficult due to slippery roads, low visibilities, and quickly accumulating snow.
As always, we'll have the latest information right here on our website with closings (here), road conditions (here), and the latest forecast and conditions (here).


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Colorectal Cancer
Colorectal cancer remains the second most common cause of cancer death in the United States, although as much as 70% of cases thought to be preventable through moderate dietary and lifestyle modifications (Anand 2008; Thompson 2011).
The colorectal cancer mortality rate has consistently declined in recent decades due largely to enhanced accuracy of early detection techniques, such as colonoscopy. However, the outlook for colon cancer patients rapidly diminishes if the cancer has metastasized to other organs or lymph nodes before detection.
If the cancer is detected while still localized in the colon, it is removed surgically and adjuvant techniques may be employed post-surgery to improve the chance for sustained disease-free survival. Treatment for advanced metastatic colon cancer usually encompasses multi-agent chemotherapy accompanied by palliative radiation.
Unfortunately, conventional standardized chemotherapy regimens may be ineffective for some patients due to genetic resistance against the drugs employed. Further, rarely do mainstream oncologists implement nutritional therapeutics or novel drug strategies to target genetic abnormalities associated with colon cancer growth, despite the fact that many peer-reviewed studies highlight the potential value of these agents.
Investigations have shown that several factors such as dietary habits, nutritional status, and inflammation influence the genetics involved in colon cancer development and progression, thus revealing multiple targets of interest in the prevention and management of colon cancer.
For example, a review of nine studies found that for every 10 ng/mL increase in serum vitamin D, the relative risk of colorectal cancer decreased 15% (Gandini 2011). Another landmark trial revealed that daily low dose aspirin reduced the risk of developing colon cancer by 24% and the risk of dying from the disease by 35% (Rothwell 2010).
In recent years, the introduction of advanced cancer analytical technology such as circulating tumor cell testing and chemosensitivity assays has improved outlook considerably by paving the way towards individually tailored treatments based upon the unique cellular characteristics of each patient's cancer.
In this protocol, you will learn about several unappreciated risk factors for colorectal cancer, and gain insight into several genetic and molecular mechanisms that drive the evolution from healthy cells to cancerous cells in the colon. You will also discover evidence-based methods for targeting these risk factors and carcinogenic mechanisms using natural compounds and novel drug strategies. Life Extension will also present resources and guidance for thoroughly analyzing the unique biological characteristics of your cancer cells, which is a critical step towards establishing an effective, personalized cancer treatment regimen.
About the Colon
The colon is the third-to-last section of the gastrointestinal tract in humans, followed by the rectum and anus. Food is mostly digested by the time it reaches the colon, so the role of this segment of the large bowel is to absorb water, some short chain fatty acids from plant fiber and undigested starch, sodium, and chloride, and compact waste to be eliminated during defecation. Moreover, colonic bacteria play a central role in metabolic detoxification by secreting chemicals that encourage excretion of toxins and pathogens. Beneficial bacteria in the colon (probiotics) also ferment dietary fiber and generate compounds, such as butyrate, which nourish cells in the colon wall and protect against carcinogenesis.
Causes of and Risk Factors for Colon Cancer
Risk factors for colorectal cancer include age (90% is found in those over 50), personal history of polyps or adenomas, family history of colorectal cancer, and diagnosis of inflammatory bowel disease (Crohn's or ulcerative colitis). Other risks include a diet high in fat or low in fruits and vegetables, physical inactivity, obesity, smoking and excessive alcohol consumption (Benson 2007).
As mentioned in the introduction of this protocol, as much as seventy percent of colon cancers are thought to be preventable through diet and lifestyle modification (Anand 2008).
Factors such as diet, physical activity level, tobacco use, alcohol consumption and sleep patterns are associated with increased risk of colorectal cancers (Schernhammer 2003). Obesity and physical inactivity are known to increase biomarkers of inflammatory processes, such as faecal calprotectin and serum C-reactive protein (CRP); elevated levels of inflammation are linked with higher rates of colorectal cancer. Greater vegetable and fiber intake has been associated with reduced levels of fecal calprotectin, a marker of intestinal inflammation.
A colon cancer treatment or prevention plan should start with foundational lifestyle measures that include physical activity and a diet rich in plant foods; patients should also strive to attain a healthy body weight.
Genetics and Family History
Genetic alterations, both inherited and non-inherited, are responsible for the carcinogenic process in colon cancer. About 75% of colorectal cancers are "sporadic," meaning that they arise in those without any family history of this disease, while the remaining 25% have an inherited predisposition that raises risk (NCI 2011).
Two familial disorders raise risk significantly, familial adenomatous polyposis (FAP) and hereditary nonpolyposis colon cancer (HNPCC, or Lynch syndrome). These inherited disorders are responsible for 1-2% and 3-5% of all colorectal cancers, respectively.
Familial adenomatous polyposis syndrome causes hundreds to thousands of polyps to form before age 30 and often leads to colon cancer at a young age (average age 39 years old). Familial adenomatous polyposis arises from inherited mutations of the adenomatous polyposis coli (APC) gene, a gene mutation that is also present in 60-80% of sporadic colon cancers.
Hereditary nonpolyposis colon cancer does not cause the multitude of polyps, but polyps are much more likely to become cancerous in those with this disorder. Those with hereditary nonpolyposis colon cancer have mutated mismatch repair genes (MMR genes), which fail to make necessary corrections to errors in DNA replication, allowing mistakes in the DNA to accumulate and colon cancer to ensue.
Metabolic Syndrome and Inactivity
Higher levels of insulin and glucose in the blood can increase the risk of developing colorectal cancers (Bruce 2005). An analysis of clinical data from 1966 through 2005 found that a diagnosis of diabetes raised the risk of colon cancer by more than 30% in both men and women (Larsson 2005).
A recent study, which looked at much of the previous data on diabetes and risk of colon cancer, concluded that diabetes is an independent risk factor for developing colon cancer (Yuhara, Steinmaus 2011).
The link between elevated insulin levels and colon cancer may be mediated though the insulin-like growth factor-1 receptor (IGF-1R). Insulin activates IGF-1R, which in turn functions to stimulate cellular growth and proliferation. Overexpression of IGF-1R has been observed in colon cancer cells, suggesting an increased sensitivity to the growth-promoting effects of insulin (Thompson 2011).
Obesity is a risk factor for developing cancers in general, and studies show that reducing weight can reduce inflammation in the colon, thereby reducing risk of colorectal cancers (Pendyala 2011). Adipose tissue (fat tissue) is not simply an inert storage system for excess calories - it actively produces many adipokines, or chemical messengers, that circulate throughout the body. One such adipokine, leptin, is linked specifically to the increased risk of developing colon cancer (Drew 2011).
Regular physical activity, which combats all the components of metabolic syndrome, is associated with a decreased risk for colorectal cancer as well. One study compared those who did not have a sedentary job with those that worked a sedentary job for 10 years or more; the risk of cancer arising in the left (distal) colon was doubled, and the risk of developing rectal cancer increased 44% (Boyle 2011).
InflammationPeople with chronic inflammatory conditions of the bowel, such as Crohn's disease or ulcerative colitis (UC), have up to a six times greater risk of developing colon cancer than those without the conditions (Mattar 2011). However, the inflammatory process is involved in the development of colorectal cancer growths even in those without Crohn's or ulcerative colitis (Rhodes 2002; Terzić 2010).
Cyclooxygenase-2 (COX-2) is an enzyme that produces inflammatory end products by converting the omega-6 fatty acid arachidonic acid into prostaglandin E2, which promotes growth of cancerous cells; COX-2 is often overexpressed in colon cancer. Aspirin blocks COX-2 and has been shown to also lessen the development of colorectal cancers (Din 2010).
5-Lipoxygenase (5-LOX), similarly to COX-2, metabolizes arachidonic acid into metabolites that drive development and progression of cancer. In colorectal cancer, 5-LOX expression was shown to correlate with the density of blood vessel growth within tumors (Barresi 2008). Moreover, 5-LOX is overexpressed in pre-cancerous polyps, and inhibition of 5-LOX caused a suppression of tumor growth in a murine colorectal cancer model (Melstrom 2008). A compound extracted from Boswellia serrata, called 3-O-acetyl-11-keto-ß-boswellic acid (AKBA), is a powerful inhibitor of 5-LOX and may modulate the cellular properties of colorectal malignancies (Yadav 2011; Bishnoi 2007).
For a complete discussion of the roles of COX-2 and 5-LOX in cancer development and progression, see the Cancer Treatment Critical Factors protocol.
More recently, NF-Kappa B (NF-kB), a pro-inflammatory mediator that influences more than 500 genes involved in proliferation, angiogenesis, immune evasion and metastatic spread, has been the topic of intense research. Not surprisingly, NF-kB is a target for thwarting cancer's growth and many natural agents act on NF-kB to prevent its signaling. The most notable natural agent able to suppress NF-kB signal transmission is curcumin (Gupta 2011). The high intake of curcumin, and resultant inhibition of NF-kB, may be one reason that the incidence of colon cancer in India is so much lower than in the US or Europe (Aggarwal 2009).
Low Vitamin D Levels
More akin to a hormone than a vitamin, vitamin D broadly influences the genome by activating the vitamin D receptor in the cell nucleus. Activation of the vitamin D receptor is estimated to modulate as many as 2,000 genes, many of which are related to inflammation and cellular mutation – initial drivers in all cancers (Smith 2010).
As mentioned in the introduction of this protocol, a review of nine studies found that for every 10 ng/mL increase in serum vitamin D, the relative risk of colorectal cancer decreases 15% (Gandini 2011). These findings are consistent with the conclusion of a large, case-control study across 10 European countries, which also found that as vitamin D blood levels rose, the risk for colorectal cancer declined considerably. Compared with those in the lowest quintile (1/5th) (<10 ng/mL), those in the highest (>40 ng/ml) had a 40% lower risk of developing colorectal cancer (Jenab 2010).
Individuals with colon cancer appear to have lower levels of vitamin D at the time of diagnosis as well. Serum vitamin D levels were insufficient (less than 29 ng/mL) in 82% of patients with stage IV colon cancer at the time of diagnosis (Ng 2011).
Low levels of vitamin D may adversely impact prognosis as well. One large study found an inverse association between serum 25-hydroxyvitamin D at the time of diagnosis and colon cancer mortality (Freedman 2007). Individuals with 25-hydroxyvitamin D levels over 32 ng/mL had a 72% reduction in mortality compared to those with blood levels less than 20 ng/mL.
Life Extension encourages the maintenance of serum 25-hydroxyvitamin D levels between 50 – 80 ng/mL for optimal health. This typically necessitates supplementation with 5,000 – 8,000 IU of vitamin D daily, but supplemental doses should always be determined by blood test results.
Low Folate and B-vitamin Intake
Homocysteine is an indirect marker for folate, B6 and B12 status. Homocysteine can be high when there is a deficiency in any of these B vitamins. Folate deficiency is associated with greater risk of developing colorectal cancers. In a large pooled analysis of data from 13 prospective studies including over 725,000 subjects, the highest quintile of folate intake was associated with a 15% reduced risk of colon cancer compared to the lowest quintile of intake (Kim 2010).
Pathology and Tumorogenesis
Colorectal cancers begin with epithelial cells that line the surface of the colon along finger-like projections called villi. The spaces between the villi are called crypts, and at the base of each crypt are immature stem cells that give rise to ever-renewing cells that migrate up the crypt and toward the tips of the villi. This normal cellular process is strictly governed by a balance of cellular renewal (normal proliferation) and cellular death (apoptosis), as well as elegantly choreographed expression of various genes along the path from immature stem cells to mature epithelial cells.
Early in the course of colon cancer development, however, the normal renewal of cells is disturbed. Cellular maturation (differentiation) is blocked and apoptosis is impaired leading to an accumulation of immature cells in the crypts. This is called an "aberrant crypt" and it is the first step in the carcinogenic process of colorectal cancers (Boman 2008; D'Errico 2008).These aberrant crypts almost always involve a genetic pathway that both embryos and colon cancer have in common, a pathway called Wnt (Abdul 2010). Many natural agents exert protective action through influencing this Wnt pathway, including components of black tea (Patel 2008a), green tea (Hao 2007) and turmeric (Mahmoud 2000).
Once the aberrant crypt forms, it may go on to become a polyp, which is a growth along the lining of the colon that can be seen during a colonoscopy exam. Polyps are benign, but they can progress to adenomas, which are considered precancerous. If further mutations occur, an adenoma can then progress to cancer over years or decades. This is the primary reason that screening colonoscopies are recommended, to remove the polyps or adenomas before they have a chance to become cancer.
Genetic Abnormalities in Colorectal Cancer
Several genes and/or genetic processes are frequently malfunctional in colon cancer cells, and therefore have become intriguing targets for treatment interventions. Some dietary compounds have been shown to influence these genes and may modulate colon cancer development and progression.
KRASKRAS is a gene that orchestrates cellular receptor sensitivity to a number of growth factors. When KRAS is activated, cellular proliferation is enhanced, while deactivated KRAS slows proliferation. In several types of cancer, including colorectal cancer, KRAS is mutated in such a way that causes it to be chronically activated, leading to unabated cellular proliferation. Mutations in KRAS are present in up to 40% of colorectal cancers (Thompson 2011).
While drugs that directly target KRAS are not yet available, the mutational status of this gene helps determine the likelihood that certain anticancer agents will be effective. For example, the anti-EGFR antibodies cetuximab and panitumumab may be ineffective if activating mutations in KRAS are present (Lin 2011).
Several natural compounds have been shown to target the KRAS pathway, including:
- Perillyl alcohol, a substance extracted from citrus fruits (Bland 2001; Asamoto 2002);
- Curcumin (Nautiyal 2011);
- Fish oil (Morales 2007);
- Tea polyphenols (Wark 2006).
Epidermal growth factor receptor (EGFR) is a protein expressed on the surface of epithelial cells that variably regulates a number of pathways involved in cellular growth and proliferation. The KRAS pathway is among those that EGFR effects.
Overexpression of EGFR is observed in approximately 65 – 70% of colon cancers, and is associated with an advanced disease stage (Thompson 2011).
Activation of EGFR stimulates KRAS-induced signal transduction leading to proliferation. However, in KRAS mutant (upregulation; overexpression) cancer cells, binding of EGFR is not necessary to activate KRAS. Therefore, medications sometimes used to treat colon cancer, called anti-EGFR antibodies, are only effective in patients not harboring a KRAS mutation (Bohanes 2011). For example, cetuximab is a monoclonal antibody against EGFR indicated for metastatic colorectal cancer in patients not carrying a KRAS mutation.
Natural compounds shown to modulate EGFR include:
- Genistein (an isoflavone from soy) (Yan 2010);
- Curcumin (Lee 2011);
- American ginseng (Dougherty 2011).
Note: Targeting EGFR directly may not be beneficial in a colorectal cancer patient overexpressing KRAS (constitutional activation). However, the aforementioned nutrients may also influence transcription downstream of EGFR and KRAS; thus they may be capable of inducing cell cycle arrest in KRAS mutant or wild type cancer cells. For example, curcumin was shown to act synergistically with dasatinib to reduce KRAS mutant colon cancer cell viability through alternative pathways (Nautiyal 2011); the other nutrients likely target additional pathways as well.
Microsatellite Instability (MSI) and Mismatch Repair Mutations
The human genome contains thousands of short, repeated base pair sequences called microsatellites, which vary in length from person to person, but are all the same length in an individual. DNA damage induced by factors such as oxidative stress and chemical carcinogens can cause dysfunction of genes responsible for ensuring that the microsatellites remain of consistent length; these genes are called mismatch repair genes. Mismatch repair gene mutations lead to microsatellite instability (MSI) – the lengthening or shortening of microsatellites. This causes dysfunction in the region of the genome containing the unstable microsatellites. If this occurs in a tumor suppressor region, the consequence can be uncontrolled cell growth, the hallmark of cancer.
Microsatellite instability is found in about 15% of colorectal cancers (Boland 2010).
Ironically, MSI (versus stable microsatellites) is associated with a better prognosis in colorectal cancer (Bohanes 2011), likely for the same reasons that it leads to cancer in the first place – the cells are unable to repair major DNA damage and thus more readily succumb to apoptosis.
- Tea polyphenols (Jin 2010; Dai 2008) have been shown to inhibit the proliferation of MSI colon cancer cells;
- Cells with disrupted MMR function are highly sensitive to the apoptotic effects of curcumin (Jiang 2010).
Screening for Colorectal Cancer
Colonoscopy is an endoscopic process using a lens that allows a physician to visualize the mucosa from the rectum to the start of the colon (ileo-cecal junction). Removal of adenomatous polyps during colonoscopy has been proven to lower the risk of colorectal cancer (Cummings 2011; Winawer 1993).
Screening colonoscopies are recommended beginning at age 50, but those with any risk factors and/or a family history should consider screening at an earlier age.
How a colonoscopy is performed and by whom may influence whether or not adenomas or cancers are detected. During a 15 month period, analysis of 7,882 colonoscopies performed by 12 experienced gastroenterologists found that the time it took to withdraw the colonoscope influenced detection rates. Gastroenterologists who took less than 6 minutes to withdraw the scope were much less likely to detect cancer than those who withdrew the scope more slowly (up to over 16 minutes.). Even advanced cancers were more likely to be missed when the scope was withdrawn more quickly (Barclay 2006).
The time of day the colonoscopy is performed may also influence its reliability. In a chart review of a total of 2,087 colonoscopies at Metro Health Medical Center in Cleveland, Ohio, those done in the afternoon had a significantly higher failure rate compared to those done in the morning (Sanaka, 2006). The "failure" of a colonoscopy means that the scope could not reach the start of the colon (the cecum). This incomplete look at the colon often necessitates repeating the scoping procedure or undergoing further imaging, such as a CT scan.
The rate of incomplete colonoscopies may be influenced by who performs the procedure. In a study designed specifically to look at factors that lead to incomplete colonoscopies, the elderly, females, and those that have had prior abdominal or pelvic surgeries are more likely to have an incomplete colonoscopic evaluation. In this same study, the researchers found that having the colonoscopy done in an office rather than hospital setting tripled the risk of new or missed colon cancer in men and doubled it in women (Shah 2007).
Computer Tomographic Colonoscopy (CTC) is sometimes referred to as a "virtual colonoscopy". It involves the use of CT imaging the colon. Preparation for CTC is much like a traditional colonoscopy with the use of laxatives to create an empty bowel. Carbon dioxide or air is infused through the rectum to create a smoother surface to assess. CTC's are useful for larger polyps but may not pick up smaller or flattened polyps as well as traditional colonoscopy. If any polyps or suspicious areas are seen on CTC, the patient must then undergo a colonoscopy to visually assess and/or remove the polyps.
CTC is limited in some extent relative to a traditional colonoscopy in that if a polyp is detected, it cannot be removed during the procedure. This is a disadvantage as the patient will then need to undergo a traditional colonoscopy following the CTC to remove the polyp. Another disadvantage of virtual colonoscopies is the high levels of radiation needed to perform the procedure.
Fecal Occult Blood Test (FOBT) Occult blood in the stool can be detected with a simple test and is recommended as routine screening for colorectal cancers. Long before blood can be seen by the naked eye, minute quantities may signify the presence of cancer. The association of a positive FOBT with actual colorectal cancer, however, is fairly low, only 10% (Manfredi 2008). This is because occult blood more often comes from benign conditions, such as minor hemmorhoids; a FOBT may even detect bleeding associated with the upper gastrointestinal tract.
The FOBT is about 70% sensitive to the detection of colorectal cancer, while a colonoscopy performed by an experienced gastroenterologist is roughly 95% sensitive (Rex 1997; Niv 1995).
Indirect Tests for Colon Cancer and Emerging Techniques
Colon Cancer Specific Antigens (CCSA's): A blood-based means of detecting colon cancer may be right around the corner. CCSA's are nuclear matrix proteins that are unique to colon cancer cells. When circulating, these CCSA's serve as a "fingerprint" indicating that either colon cancer or a premalignant adenoma is likely present (Leman 2008). Circulating levels of several of the CCSA's, including CCSA-2, CCSA-3 and CCSA-4 have all been independently shown to be both sensitive and specific to colon cancer or premalignant adenomas (Leman 2007; Walgenbach-Brunagel 2008). While this test is not commercially available yet, ongoing research is looking at optimizing combinations of the different CCSA's to predict the likelihood of colon cancer with great accuracy. In the future, this blood test may be used to gauge the urgency for colonoscopy screening.
Calprotectin in the stool has been used as a marker for IBD, and is a useful tool in determining the possibility of adenoma or colorectal cancer (Kronborg 2000; Roseth 1993). Fecal calprotectin is a product of granulocyte formation, a hallmark of chronic inflammation, and as such is not specific to the cancerous process but indicates that inflammation is present. In one study, of the patients referred for colonoscopy due to abdominal symptoms, elevated calprotectin was found in 85% of those with colorectal cancer, 81% of those with IBD and only 37% of those with normal findings (Meucci 2010).
Molecular Markers in the Stool: Since precancerous adenomas and colon cancer arise in the lining of the colon, the cells involved are shed with the stool on passing. With advances in technology and molecular biology, examining the stool for unique DNA changes that signify cancer is an area of interest.
The next generation of stool testing for colon cancer involves the stool DNA (sDNA) test, which was able to detect 64% of precancerous adenomas greater than 1 cm and 85% of colon cancers, and the fecal immunochemical test (FIT) (Ahlquist 2010). A patented stool DNA test called PreGen-Plus™ is approximately 65% sensitive to the detection of colorectal cancers (PreGen-Plus™ fact sheet 2011), but the high cost of this test may limit its utility for many consumers.
These non-invasive tests remain less sensitive than a colonoscopy, and have advantages and disadvantages that should be discussed with a healthcare provider (Cummings 2011).
Following diagnosis, oncologists and pathologists must analyze the extent to which the cancer has progressed and determine whether it has metastasized to other organs. This process, called "staging", is crucial in guiding treatment.
Cancer confined to the mucosa of the colon wall is classified as stage I and is easily removable by surgery in the great majority of cases. When the cancer has penetrated deeper into the muscle layers of the colon, or has just perforated the colon wall, it is classified as stage II. Stage II colon cancer also carries a fairly good prognosis. Stage III is defined by detection of cancer in nearby lymph nodes, tissues or organs. Stage IV colorectal cancer defines metastasis to one or more distant organs, such as the lungs.
The outlook diminishes as stages advance; surgery is usually no longer a curative option for cancer not contained within the colon or isolated to nearby tissue (colon cancer with isolated liver or lung metastasis can rarely be treated effectively with surgery). Five-year survival rates for stage I colon cancer are very good, at about 90%, while the median survival plummets to just six months in advanced stage IV cancer (Crea 2011).
A valuable innovation in cancer prognostic technology is circulating tumor cell testing. Circulating Tumor Cell testing involves the detection of cancer cells in the bloodstream. These circulating tumor cells are the "seeds" that break away from the primary site of cancer and spread to other parts of the body. Understanding circulating tumor cells is critically important since it is the spread of cancer to other parts of the body—and not the primary cancer—that is very often responsible for the death of a person with cancer. For a detailed discussion of circulating tumor cell testing, please refer to section three of the Cancer Treatment: Critical Factors protocol.


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Timothy Omundson, 'Psych'
You know him as: Detective Carlton Lassiter Why we like him: Over six seasons of the comedy detective series, Omundson has deftly revealed that beneath the bullet-proof vest of the trigger-happy squirrel assassin lies a vulnerable heart. After years of violently resenting Shawn and Gus' interference in his police investigations, he's finally developed a grudging respect for their skills, and through his romance with a criminal (Kristy Swanson), we've seen even more of his softer side. And Omundson is a master at playing the straight man opposite a couple of goofballs. Where else you've seen him: "Deadwood," "Judging Amy" -- Drusilla Moorhouse, Zap2it
Copyright © 2018, Chicago Tribune


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My morning started as most of my mornings do, Tablet in hand I trudge around my house making sure my little ones are getting breakfast and readying for school. I flick through all of the news and commentary I may have missed in the last 8 hours, catch a few webcomics, and if I am feeling adventurous I will even check out Twitter. This was one such morning where a flick through twitter revealed more than a few people upset that someone had discovered a "kill switch" in the Thunderbolt source code. Through the Droid Rage, it was pointed out that this bit of code is not exclusive to the Thunderbolt.
You can find the snippet of code that I will be referring to HERE.
This code, more commonly referred to as the Master Clean command, it not some evil weapon that carriers, manufacturers, or even Google would wield over you for committing some heinous crime. In fact, this code exists on every Android device, including ones compiled via AOSP. It's there for local network administrators. This is a corporate feature to enable a sys admin to wipe a phone that's been misplaced, stolen, or even picked up by a wannabe reporter in a strange bar. It's a simple security feature to protect a company from losing valuable or secure data.
So in a couple of months, when the next insanely hyped Android phone comes out, and a week or so later you hear that a super secret "kill switch" was installed to brick your phone if you misbehaved, please remember this article, as I am sure it will be just another retelling of this same old tale.
Huge thanks to @teamANDIRC for the tip!


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Words containing phped
Found 2 words containing phped. Browse our Scrabble Word Finder, Words With Friends cheat dictionary, and WordHub word solver to find words that contain phped. Or use our Unscramble word solver to find your best possible play! Related: Words that start with phped
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Jets blast Raiders in ACAC first round
MONROEVILLE—The ACAC co-champion Lady Jets moved on as predicted against a struggling Southern Wells squad in two, but the South Adams Lady Stars nearly pulled off the unlikely upset against the Leo Lions losing in three sets to the other co-champs.
In the Adams Central contest, there was not much to make the trip for it seemed. In a match that lasted 25 minutes, the Lady Jets took care of business sweeping the Raiders in two games 25-8, 25-7 as if it were a tune up game for Woodlan against Thursday, which it turned out to be with the Warriors advancing to Thursday's semi-finals as well with a win past Heritage.
"They had fun tonight and we played as a team," AC coach Ashley Beard noted after the contest. "Our game was on tonight."
The Lady Jets entered the contest with a renewed sense of focus after South Adams took them to a five-set decision in last Thursday's match at the Stardome.
"They (SA) played a heck of a game against us and we knew we had to work harder after that," Beard analyzed. "Since then we've had some good practices. It was all about getting us back to where we were for tonight. We did not back down at all in tonight's match and that was our goal."
In the first set, AC leapt out to a 5-0 start before SW got on the board with a Jet missed serve. After a few exchanges of serve, the Jets made another stretch of points jumping out to a 13-4 edge, then 17-4. Soon the Jets were up 21-7 leaving the Raiders lost on their service return. AC would nab four of the final five points to seal the first set.
The second set did not change tempo in the least for Adams Central as they kept their foot on the accelerator. Despite Southern Wells earning the first point (their only lead of the match), the Jets would get the next five to go back up 5-1. Outscoring the Raiders 20-6 the rest of the way, AC traded four points for every one of SW's earning a lopsided 25-7 decision sealing the match.
Haley Gross led the attack with seven kills, a block and four assisted swats at the net. Whitney Peterson chimed in with six kills and a block, Madi Schwartz had three assisted blocks and 18 assisted kills, Bess Fiechter had four kills and a block, and Jenny Schultz had two digs and five aces.


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fini — Read signals from a file at i-rate.
ifilename -- input file name (can be a string or a handle number generated by fiopen)
iskipframes -- number of frames to skip at the start (every frame contains a sample of each channel)
iformat -- a number specifying the input file format. If a header is found, this argument is ignored.
0 - floating points in text format (loop; see below)
1 - floating points in text format (no loop; see below)
2 - 32 bit floating points in binary format (no loop)
fini is the complement of fouti and foutir. It reads the values each time the corresponding instrument note is activated. When iformat is set to 0 and the end of file is reached, the file pointer is zeroed. This restarts the scan from the beginning. When iformat is set to 1 or 2, no looping is enabled and at the end of file the corresponding variables will be filled with zeroes.
Please note that since this opcode generates its output using input parameters (on the right side of the opcode), these variables must be initialized before use, otherwise a 'used before defined' error will occur. You can use the init opcode for this.


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Harry Styles, a 20 year old, and Maliyah Styles, a...
Against Her Will
- by tia.leiby
- Rating:
- Published: 25 Apr 2014
- Updated: 13 Jun 2014
- Status: In Progress
Belle lives in a town where murders are suddenly happening out of the blue. Of course, she doesn't want to stay here anymore but doesn't have a place to go. Soon Belle has the unfortunate displeasure of being held captive by the serial killer himself. Everyday, she has to look him in the eye and tell him that she loves him. She doesn't mean it of course! What happens when one day, she actually means it?
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Turn sidewalks into runways with these sweet, playful designs. The surprising detail and nuances are what make Electra Fashion bikes unique. There's a style for every personality and each one features our patented Flat Foot Technology® for amazing comfort and control. Take a ride and you'll realize that beauty is way more than skin deep.
- 6061-T6 aluminum Boomerang frame
- Shimano Nexus internal 3-speed w/coaster brake
- Shimano Nexus Revo shifter
- Alloy crank and sealed cartridge bottom bracket
- Shimano front roller brake and hub
- 26"x 2.125" tires
- Matching bell
- Genuine leather streamers
|Electra Boomerang 6061-T6 Alloy Flat Foot Technology®
|High Tensile Steel Uni-Crown
|1" Threaded Steel
|Electra Custom Alloy Painted and Decaled 36H
|Front: Shimano Roller Brake Alloy 36H; Rear: Shimano Nexus 3-Speed w/Coaster 36H
|14G Stainless/Brass Nipples
|Electra RetroRunner 26" X 2.125"
|Electra Custom Alloy 3-Piece 170mm
|KMC 410 Nickel Plated
|Cassette/Rear Cogs
|Shimano 22T
|Shimano Nexus 3-Speed Twist
|Electra Cafe
|Electra Wild Flower Hand-Stitched Leatherette
|Forged Alloy 22.2mm Quill
|Brake Levers
|Alloy Reach Adjustable
|Electra Retro
|Electra Wild Flower Tassel Design w/Double Coil Spring
|Seat Post
|Classic Alloy Pillar 27.2mm X 300mm
|Accessories & Extras
|Painted Fenders, Integrated Kickstand, Stainless Steel and Anti-Rust Hardware & Bell, Genuine Leather Tassels
* Subject to change without notice.Back to top
|Manufacturer's Part Number
|Dark Grey Metallic
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I finally have the bike of my dreams. I have been drawn to Electra Cruiser bikes for almost a decade and finally bought one. My husband and I recently decided to replace our old mountain bikes with new road bikes. He did all the research on that, and I kept being drawn like a magnet towards the Electra Cruisers. While we did each purchase new hybrid fitness road bikes, I told him that the fitness bike really wasn't the ride of my dreams and that I wanted a Cruiser as well, for when we weren't going on road trips together. It is a trip down memory lane to ride my Wildflower Cruiser. If you want a smooth ride, this is as comfy as riding in my uncle's old Lincoln back in the 60's and just as stylish. I turn 60 next year and wanted a comfy bike that I could ride around town that didn't cause any bone jarring bumps or leave me with a sore butt at the end of the day. I enjoy the comfortable ride so much that I've found myself going on much longer bike rides that don't leave me feeling achy or jolted afterwards. The flat foot technology is also very reassuring when coming to a stop. My bike is extremely stylish and classy and I get plenty of compliments on it. I've recently added a pet carrier to the back of my bike since my Shih Tzu/Lhasa Apso dog likes to ride in comfort as well. I'm ecstatic with this bike and with our shopping experience where we purchased all 3 of our bikes. (St. Albert, AB) Take an Electra Cruiser for a test drive today. You won't regret it.
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The iPhone 5 is still hot on everybody's mind, but it seems like a lot of people (journalists, at least) aren't sold on Apple's new phone. If you're among them, you may want to watch this video. MondoMedia has resurrected everyone's favorite Apple CEO, the late Steve Jobs, to sell us on the iPhone 5 in manner similar to hologram Tupac — brought back to life to save Apple. Though I don't remember Steve Jobs being a prolific rapper, as a hologram, he can certainly lay out some rhymes. His iPhone 5 song is pretty catchy… maybe Tim Cook really should start wearing the Jobs trademark turtleneck. Oh, what does it matter. People will still buy iPhones anyway according to hologram Jobs.
As a note, this video doesn't have anything too offensive in it, but there are some light swearing. And if holographic, animated Steve Jobs makes you want an iPhone 5, be sure to check out our buyer's guide. Pre-orders are starting Friday.