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Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.
Issue link: https://gen.epubxp.com/i/145822
TUTORIAL Drug Discovery Removing the Receptor Deconvolution Bottleneck Powerful Tool Aims to Uncover Novel Disease-Relevant Drug Targets Jo Soden and Jim Freeth, Ph.D. Progress in the study of normal biological processes, or the mechanism of disease, has traditionally been hampered by the immense challenge in identifying the specifc binding partners for a natural ligand or pathogen. Similarly, in drug discovery, the success of phenotypic screening approaches ultimately relies on deconvoluting the targets of any phenotypic molecules before these leads can be progressed. In the case of antibodies or peptides (i.e., biologics), the binding targets will generally be receptors or other types of cell surface protein. Until recently, the hit rate for accurately identifying a cell surface protein interaction was approximately 10% using techniques such as standard protein chips or immunoprecipitation and mass spectrometrybased methodologies. However, a validated high-throughput approach—using a cell microarray technology developed by Retrogenix—has now increased the likelihood of success to more than 60% and has already contributed to breakthroughs in malaria research and the deconvolution of receptor(s) for many antibody ligands. The elegance of the Retrogenix microarray system lies in expressing full-length human membrane proteins in the context of human cells. This allows for normal traffcking of the proteins to the cell surface, correct folding in the plasma membrane, and natural posttranslational modifcation. Once expressed in their native state on the cell surface, these proteins are then available to interact with the Jo Soden is scientifc director and Jim Freeth, Ph.D. (email@example.com), is managing director at Retrogenix. Web: www.retrogenix.com. test ligand. Representation of a large proportion of the plasma membrane proteome in a physiologically relevant system underpins the success of this technology in detecting specifc hits for a variety of applications. This tool utilizes a proprietary library of expression vectors containing open reading frames (ORFs) encoding more than 3,500 fulllength human plasma membrane proteins, as well as a green fuorescent protein (GFP). Each vector is combined with a lipid and the complexes are spotted in distinct locations on glass slides. Human cells are then grown to confuence over the spotted slides. Reverse-transfection of the cells sitting over each expression vector results in overexpression of each respective membrane protein, along with GFP. The ligand (e.g., protein, virus, phenotypic molecule) is applied to the cell microarrays and putative receptor targets identifed by analyzing "gain-of-binding" using an appropriate detection system (Figure 1). The GFP acts to determine spot coordinates, as well as provide a quality control to ensure that the minimum transfection threshold has been exceeded. Typically, further tests are then undertaken to determine that the receptor "hit" is reproducible and confrm specifcity to the test ligand. The current set of 3,500 plasma membrane proteins spans a broad spectrum of membrane protein subclasses, and is biased toward membrane proteins with an extracellular domain (ECD). As shown in Figure 2, good coverage across all subclasses of plasma membrane protein has been achieved. Of these 3,500 full-length ORFs, about 2,600 represent different genes, while the others represent alternative variants of the same genes, particularly where variants in the ECD exist. This collection is the largest set of commercially accessible plasma mem- Figure 1. Schematic representation of Retrogenix' cell microarray technology 20 | August 2013 | GENengnews.com | Genetic Engineering & Biotechnology News brane protein expression clones, and currently represents approximately 60% of the known human plasma membrane proteome. Notable Applications This technology has proven successful in uncovering the cell surface receptors of orphan ligands, which play a key role in normal or disease processes. Such ligands include natural soluble proteins and peptides, viruses, and cell surface-derived ligands (i.e., those mediating cell:cell interactions). A study published in Nature in June 2013 describes how Retrogenix' technology identifed the key receptor responsible for severe childhood malaria. This receptor, known as endothelial protein C receptor (EPCR), is responsible for binding and sequestration of malaria parasiteinfected erythrocytes to blood vessels in the brain, likely to be interfering with anti-infammatory and antithrombotic actions of EPCR. Of the 2,500 human plasma membrane proteins screened, EPCR was identifed as the single specifc hit—an event described as a "true eureka moment" by the lead researcher at the University of Copenhagen. Despite this contribution to malaria research, to date, the Retrogenix technology has been more extensively used for deconvoluting the cell surface targets of phenotypic antibodies that have been discovered using a phenotypic screening approach (Figure 3). One advantage of phenotypic screening over the alternative, target-led approach to drug discovery, is that completely new disease-relevant targets and pathways are being discovered. Retrogenix' technology has identifed many new drug targets on behalf of its part- ners. These have included receptor-type kinases, GPCRs, immunoglobulin superfamily members, anchor proteins, and others. In some cases, these have even been multisubunit receptors such as integrins, the additional subunits presumably being provided by the cells endogenous machinery, highlighting a further advantage of physiological systems over traditional protein chips. In addition to isolating a primary target, Retrogenix' technology provides a tool to uncover the secondary or off-target activities of antibody and protein drug leads. This assists in candidate selection as it reduces the risk of future, costly failures that are due to off-target driven toxicities. A Versatile and Scalable Technology As well as its applicability to a wide range of ligand types (e.g., antibodies, proteins, viruses), Retrogenix has developed and validated a range of detection systems for protein ligands (anti-His, anti-Flag, anti-V5, anti-Fc, biotinstreptavidin, directly fuorescently tagged, and radiolabeled), and for different species and isotypes of phenotypic antibodies. Crucially, the technology is highly sensitive, capable of detecting micromolar affnity ligand-receptor interactions even in the absence of any amplifcation strategies. Speed and throughput are not sacrifced for sensitivity and specifcity; Retrogenix can identify and confrm specifcity of ligand receptors in a matter of weeks, screening many molecules in parallel. Throughput is further enhanced by screening "pools" of up to 20 molecules for binding against the 3,500 membrane proteins, then subsequently matching each molecule to each receptor target. Figure 2. All subclasses of plasma membrane protein are represented in the Retrogenix library. Within some of the main subclasses, the percentage coverage of all known members is shown. Figure 3. A typical phenotypic drug discovery approach using antibodies, yielding novel disease-relevant targets and antibody leads.


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Summit League Men's Preview: South Dakota at Western Illinois
The South Dakota men's basketball team has taken care of business at home through the first two weeks of the 2014 Summit League schedule, now it's time to see how the Coyotes do away from Vermillion when they travel to Western Illinois and Omaha this week.
USD (8-9/3-0) pushed its current win streak to five last Thursday night with a win over IUPUI at the DakotaDome. It was a game that saw the Coyotes start fast, shooting 61% in the first 7:30, only to see the Jags reel off 10 straight to take a one-point lead at halftime.
In the second half, USD clamped down on defense, and turned a close game into a 12-point win after scoring 14 of the last 17 points in the game:
USD Head Coach Joey James on the hard fought win over IUPUI:
Two nights later, the DakotaDome was the site of the battle for the early lead in the conference with the unbeaten Coyotes hosting 3-0 Fort Wayne.
Fouls would be a big issue in this one, limiting USD center Trevor Gruis to just 12 minutes of playing time, sending Tyler Flack out early in the second half, and limiting Mastodons center Steve Forbes throughout the game.
The Coyotes got some key play off the bench, forcing IPFW into 10 first half turnovers, and stretching the lead to 10 at the break, before winning by 14 to take over sole possession of first place after two weeks.
Coach James on sitting Gruis for most of the Fort Wayne win:
The Coyotes will now take their perfect record on the road in the conference for the first time, starting Thursday at Western Illinois.
Coach James knows what he needs to see from his team this week:
Tipoff is Thursday night at 7:00pm in Macomb.

subset: commoncrawl


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Andries N. (d. 1570)
Andries N. is the name given by the<em> Martyrs Mirror </em>to two martyrs who were executed in 1570. The author explains the initial N. as signifying that they were dead to the world and had devoted themselves to the service of Christ. One of them died in Antwerp with his father and brother after giving a good testimony to his faith and suffering all the torture cheerfully. This martyr is identical with Andries Jacobsz. The other was imprisoned for his faith and after three hours of cruel torture was burned at the stake. This martyr, concerning whom particulars are lacking, was not executed in Antwerp, as the Martyrs' Mirror states, but at Haarlem.
Braght, Thieleman J. van. Het Bloedigh Tooneel of Martelaers Spiegel der Doops-gesinde of Weereloose Christenen, Die om 't getuygenis van Jesus haren Salighmaker geleden hebben ende gedood zijn van Christi tijd of tot desen tijd toe. Den Tweeden Druk. Amsterdam: Hieronymus Sweerts, …, 1685: Part II, 506.
Braght, Thieleman J. van. The Bloody Theatre or Martyrs' Mirror of the Defenseless Christians Who Baptized Only upon Confession of Faith and Who Suffered and Died for the Testimony of Jesus Their Saviour . . . to the Year A.D. 1660. Scottdale, PA: Herald Press, 1951: 845. Available online at: http://www.homecomers.org/mirror/index.htm.
Haeghen, Ferdinand van der., Thomas Arnold and R. Vanden Berghe. Bibliographie des Martyrologes Protestants Néerlandais. II. Receuils. The Hague: M. Nijhoff, 1890: Nos. 19, 20.
Hege, Christian and Christian Neff. Mennonitisches Lexikon, 4 vols. Frankfurt & Weierhof: Hege; Karlsruhe; Schneider, 1913-1967: v. I, 70.
|Christian Neff
|Nanne van der Zijpp
|Date Published
Cite This Article
MLA style
Neff, Christian and Nanne van der Zijpp. "Andries N. (d. 1570)." Global Anabaptist Mennonite Encyclopedia Online. 1953. Web. 21 Nov 2018. http://gameo.org/index.php?title=Andries_N._(d._1570)&oldid=53878.
APA style
Neff, Christian and Nanne van der Zijpp. (1953). Andries N. (d. 1570). Global Anabaptist Mennonite Encyclopedia Online. Retrieved 21 November 2018, from http://gameo.org/index.php?title=Andries_N._(d._1570)&oldid=53878.
Adapted by permission of Herald Press, Harrisonburg, Virginia, from Mennonite Encyclopedia, Vol. 1, p. 122. All rights reserved.
©1996-2018 by the Global Anabaptist Mennonite Encyclopedia Online. All rights reserved.


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Best Kids Parties: Trucks
Name: Yosef, 2
Location: Amherst, MA
My grandson Yosef just turned two. Since he loves any moving vehicle, the party theme was trucks!
I used little yellow toy trucks as a jumping off point and added blue for a second party color. We kept things simple since the party was small and the children were very young. See the yellow cups? They're Starbucks cold drink cups, painted yellow. The lids fit nice and snug so I knew there would not be any spilled milk with these. (The nice people at Starbucks know me since I'm there so often and gave me the cups and tops for free!)
I made the cupcake toppers using stickers, a circle punch and some other supplies. Hanging the balloons from the ceiling with string is easier than getting a bunch of helium balloons into your car.
The chocolate covered marshmallows couldn't be easier to make: put a stick into the marshmallow, dip it into melted chocolate, add sprinkles, done!
All guests went home with goody boxes filled with hard-to-find kosher candy.
Thanks, Rita! You can see more of the party over at Design Megillah.
(Images: Rita Brownstein)


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If you are not eligible for the University's group health coverage and you reside in Massachusetts, you may purchase health insurance through an "exchange" such as the Commonwealth of Massachusetts, Health Connector. The Health Connector offers a range of health insurance coverage and prices. The Health Connector plans provide long term insurance coverage, although you may cancel coverage if, for example, you become eligible for a new employer's health coverage.
To find out more about the plans offered, go to https://betterhealthconnector.com or call 1-877-623-6765.


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The Florida state board of education voted 4-3 at its February 19, 2008, meeting to adopt a new set of state science standards in which evolution is presented as a "fundamental concept underlying all of biology." The adopted standards differ from those developed by the writing committee in adding the phrase "the scientific theory of" before mentions of plate tectonics, cell theory, atomic theory, electromagnetism, and evolution. According to the standards, "a scientific theory represents the most powerful explanation scientists have to offer."
In a letter (PDF) to the Texas Commissioner of Education and the members of the Texas state board of education dated February 13, 2008, the Biological Sciences Curriculum Study expressed its opposition to actions in the state of Texas that "compromise the integrity of science and the quality of science education," citing in particular the forced resignation of Chris Comer from the Texas Education Agency and the Institute for
Anticipating the bicentennial of Charles Darwin's birth and the sesquicentennial of the publication of the Origin of Species, the Outreach and Education Committee of the British Society for the History of Science is conducting a prize competition for original designs illustrating the significance of these anniversaries. Entries may take the form of posters, illustrated essays, or screensavers.
As the Florida state board of education prepared to consider a final draft of a new set of state science standards, Floridians offered their opinions at a last-minute meeting held in Orlando on February 11, 2008. Over eighty speakers addressed the state commissioner of education, Eric Smith, and, via webcast, the board. A video of the entire meeting is available on the department's website.
Preparing for the impending bicentennial of Darwin's birth, the journal Nature (451: 632-634) commissioned Kevin Padian to consider (subscription required) Darwin's enduring legacy.
National Center for Science Education, Inc.
1904 Franklin Street, Suite 600
Oakland, CA 94612
fax: 510-788-7971
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Sri Lanka - Northern Explorer
Sri Lanka - Northern Explorer
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Prices are in:
+44 (0)191 296 2674
For expert advice get in touch now with our passionate, well-travelled team.
Toll free from the US & Canada
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The above toll free numbers will connect you directly with our office in the UK.
click for our opening times
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Looking for a guaranteed departure? Check out our latest list.
India - Big Cats and Small Kingdoms
Burkina Faso is culturally such an interesting destination with few visitors. We were very fortunate to have Sena as our delightful and extremely professional guide; he used his contacts, knowledge of the tribal areas and expertise to manage and ensure the smooth running of the trip and provided us with an incredibly colourful and interesting experience. I am so grateful to Undiscovered Destinations for taking me to such a little known area of rich tribal culture, whilst providing every care and comfort along the way. - Carol Turner, UK


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If you weren't thinking of switching to Sprint to get the HTC Hero back when it was announced, the "Now" Network just sweetened the pot with 2 fatted calves and a goat. Sprint just announced their new plan including calling any mobile phone on any provider. That's right, you can call all of your buddies on AT&T, Verizon, or T-Mobile for free. The only stipulation to the plan is that you have their Everything Data plan, which starts at 69.99. The Palm Pre owners will flip for this information, but it is the excited Android lovers thinking of jumping ship that will go for a dive to swim up on Sprint's shore for this. The plan is known as simply the Any Mobile, Anytime plan.
So, if you didn't care for the Sprint HTC Hero, or Sprint how does this make you feel now? Ready to become a member of the Now network or will you hold off to see how this all goes? Let us know.
[via Sprint]


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Multibyte for Rails: A Unicode Solution for Rails?
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The issue of proper Unicode support for Ruby on Rails continues to generate lots of discussion and development activity.
The Multibyte for Rails project was started by Julian 'Julik' Tarkhanov with the 'unicode_hacks' plugin. Manfred Stienstra, Jan Behrens and Thijs van der Vossen later joined the development team.
ActiveSupport::Multibyte extends the standard Ruby string with a chars proxy method. This proxy allows you to use a multibyte encoded string as a sequence of characters (or Unicode codepoints) instead of bytes. On chars you can call multibyte-safe implementations of all standard Ruby string methods. The proxy also provides methods for Unicode normalization, composition and decomposition and preliminary support for working with grapheme clusters.
Three months ago Julian submitted a test implementation of his ActiveSupport::Multibyte string extension patch to the Rails core team for inclusion in Ruby on Rails proper. According to a recent thread started by project team member and rails-core mailing list regular Manfred Siesta, the Multibyte team has been working continually on improvements to their extension for three months:
The code has been completely refactored to be more transparent and easier to understand. There is now a single optional accelerated backend and all multibyte-safe operations have a pure Ruby implementation. Test structure and coverage has also been greatly improved.
For anyone interested in trying out ActiveSupport::Multibyte, it is available as a plugin and can be converted to a patch using the included 'create_patch' rake task.
Why won't DHH and the core team just go ahead and patch Rails the way that folks such as Julian and his Multibyte team propose?
First of all, there is a performance penalty incurred by multibyte string operations. According to the project FAQ:
Multibyte safe operations through a proxy are obviously slower than single-byte operations directly on the string. The proxy introduces two levels of indirection and multibyte safe operations are more complex than single-byte operations and therefore slower.
A quick benchmark shows that for example a multibyte safe slice operation through the proxy is on average 50 times slower than a single-byte slice operation. Even though this makes the performance impact seem severe, remember that most of the string operations do not need to be multibyte safe. For a typical Rails application you're unlikely to even notice a performance penalty, but you have the satisfaction of knowing that you'll never break your user's text ever again.
Then there's the problem of UTF-8 and Unicode being terribly unpopular in Japan and China because of the Han Unification issue. On the other hand, as Sam Ruby pointed out in a brief comment to the rails-core mailing list:
Java and C# seem to do OK in Japan. I would also imagine that ASCII wouldn't be very popular in Japan. :-)
In the end, it seems that it will take more time before any single solution to the question of internationalization is adopted by Rails core. Copenhagen blogger Casper Fabricius sheds light on the situation based on recent comments by DHH at his user group:
...shouldn't 5 or more plugins for internationalization indicate quite clearly that the Rails community craves unified support implemented in the core?
No, DHH answered, from the Core Team's point of view, this means that people want to support and implement internationalization in a lot of different ways, and that there is no universal solution that will make everybody happy. Even inside the Core Team people can't agree how it should be done. Although, DHH added, I can't rule out that the 37signals needs internationalization, is the day that Rails get it.
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Unicode support should be part of the language not a library
Faui Gerzigerk
And we have all the character conversion stuff going on as well. Every time I read in something from an XML file/message or from a database or from an HTTP request, some conversion may be required. This has to be very fast indeed!
Re: Unicode support should be part of the language not a library
Christian Romney
Re: Unicode support should be part of the language not a library
Devin Ben-Hur
Why is this not part of Ruby itself?
If you really want to know, it's mostly because the ideographic asian languages (japanese, chinese, etc.) were given the shaft when
unicode was developed by a bunch of arrogant westerners.
Ruby's inventor is Japanese and Japan is still its main locus of use and development. Matz doesn't particularly like or need unicode, so he hasn't previously built support in to the language. However, he doesn't really to desire to cause other people pain, so he is actively working on improved unicode support for Ruby 1.9/2.0.
You can read his
ongoing thoughts and conversations. Try expressing your concerns via ruby-talk -- much more useful than complaining in a forum the language designer/implementor is unlikely to ever see.


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Wilson knuckles down to dominate Astros
HOUSTON -- At one point Monday afternoon, C.J. Wilson just decided he'd throw a knuckleball, in an actual game, for the first time ever.
"I was just out there having fun," the left-hander said.View Full Game Coverage
HOUSTON -- At one point Monday afternoon, C.J. Wilson just decided he'd throw a knuckleball, in an actual game, for the first time ever.
"I was just out there having fun," the left-hander said.View Full Game Coverage
And why not?
The roof was open, a nice breeze was making its way through Minute Maid Park and the Angels had a big lead, on their way to taking three of four from their youthful division rivals -- and Wilson, frankly, could do no wrong.
So with two outs in the seventh inning of a near-shutout, and an eventual 9-1 victory, Wilson called third baseman Ian Stewart over as the infielders tossed the ball around after one of his seven strikeouts, to let him know he'd start Astros left fielder Jesus Guzman off with a knuckleball, "because I was afraid he was going to get killed if he smashed it."
Chris Iannetta put down the signal for a changeup, trying to change speeds on a guy who doubled in the second and lined out to center in the fifth, and the crafty left-hander ignored it.
"I've been working on it," Wilson said of the knuckleball. "But it was the only pitch I've never thrown in a Major League game before. I've thrown it in warm-ups a couple times, so I was just determined at some point to filter it in there."
The knuckler, for the record, came in at 80 mph and went for a ball. The next pitch, a curveball, resulted in a hard comebacker that Wilson knocked down for the final out of the inning. And five batters later, Wilson had completed eight innings of one-run ball, six days after allowing six runs in 5 2/3 innings in his season debut against Seattle.
"Last week I pitched [terribly], so I was just determined to have a good game today," Wilson said.
All of his teammates could probably sympathize, because they entered Houston with an 0-3 record for the first time since 1992, after being outscored by 18 runs by the Mariners -- a team they'll face in a two-game set to finish off their first road trip.
But then they scored 11 runs on Friday, got a dominant outing by Tyler Skaggs on Saturday and were led by Wilson on Monday, who took the mound one day after Jered Weaver allowed a career-high-tying four home runs in a loss.
Wilson gave up four hits, didn't allow a run until Carlos Corporan's solo homer with two outs in the eighth and only walked one batter, L.J. Hoes immediately thereafter.
"In the Seattle series, we didn't swing the bat well, we didn't pitch well and we had a couple of guys on here and there, but it didn't amount to anything, really," second baseman Howie Kendrick said. "This series, it seems like we had guys on, we hit with runners in scoring position and the pitchers went out and put up zeroes for us."
The offense continues to wait on Albert Pujols, who managed a ninth-inning double, but continues to struggle with his timing and is only hitting .200. In the meantime, they got three RBIs from Raul Ibanez (his batting average up to .218) and Kendrick (.286). And they continued to get production from Josh Hamilton, who was named co-American League Player of the Week -- along with Twins first baseman Chris Colabello -- and then drew three walks for the first time in five years.
As Hamilton said: "You see more pitches if you don't swing at [garbage]."
Hamilton drew a first-inning walk against promising 23-year-old right-hander Jarred Cosart, then came around to score on Kendrick's two-run single. He walked again in the third, reached on an error by first baseman Chris Carter in the fifth and was intentionally walked by Brad Peacock with first base open in the seventh, just before a two-run single by Ibanez and a run-scoring single from Kendrick to give the Angels an 8-0 lead.
In the ninth, Hamilton drove in a run with a single up the middle, keeping his batting average at .500 through the first seven games.
"This is the real Josh," said Wilson, Hamilton's longtime teammate during his better days with the Rangers. "He's able to make good adjustments at the plate, where if guys aren't giving him anything good to hit, then he'll take the base hit up the middle or hit the ball the other way. The reason his batting average is so high right now is because he has hit balls up the middle."
Alden Gonzalez is a reporter for MLB.com. Read his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez.


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Official Gym Flooring of the Mr. Olympia
Yes, it's true. RubberFlooringInc.com is now the official gym flooring for Mr. Olympia. If you attended the event this past weekend, you would have seen our flooring in the Men's Fitness Ultimate Athlete village. It turns out the event organizers needed some non slip rubber flooring designed to provide a safe and even surface for some of the best male athletes to compete for the title of the Ultimate Athlete. Competitors were tested on basketball shooting, throwing a fastball, rowing, plyometrics, scaling a wall, lifting a punching bag above waist level a number of times, carrying weights, a cone drill, dragging a sled, and throwing a football.
The gym flooring used was our very own Eco-Flec rubber rolls which can be seen here.
To see all of our gym and weight room flooring options available, please click here.
To read more about our new partnership with Mr. Olympia, the official press release can be found here.


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From LinuxMIPS
If I installed ftp://ftp.mips.com/pub/tools/software/sde-for-linux/sdelinux-5.03.06-1.i386.rpm whould it install over my x86 gcc?
I want gdb to be installed on mips-n32 ,what the option host is?
I know when gdb is installed on mips-n64 as an native debugger ,the options host=build=target= mips64el-linux ,but what the options is when it is to be installed on mips-n32?


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UndeadFred Zombie Cookie Cutters
- Bake your own undead delights
- Three unique walker cutters
- Don't forget blood-colored gel frosting!
When you're trying to run for your life, you need fast-acting sources of energy. The best one? SUGAR! Really, any carbohydrate will do, but sugar is going to send you that jolt of energy quickly so you can make the mad dash for safety. You'll also want some fat for long-burning energy, but sugar cookies always contain a good amount of butter or shortening. Om nom nom.
Create your own delicious dead with this set of three unique zombie-shaped cookie cutters. Whip up your favorite sugar cookie recipe, dye it some sort of horrible color (green-brown?), cut them up, toss them in the fires of your oven, and then frost them into undead delights.
Product Specifications
- Set of three zombie themed cookie cutters
- Use your favorite sugar cookie recipe (dyed green, maybe?)
- Cut out the zombies, bake, then decorate!
- Material: Food-grade, BPA-free plastic
- Care: Hand-wash


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Suspect Captured In Bourbon Street Shootings
NEW ORLEANS (AP) — Police have arrested a suspect in the shooting on Bourbon Street that left one person dead and nine injured.
20-year-old Trung T. Le was identified today as a suspect in the shooting.
NOPD Chief Ronal Serpas says Le was taken into custody today in Mississippi by members of the NOPD's Violent Offender Warrant Squad and U.S. Marshals.
Serpas says Le will be taken back to New Orleans in the next few days. Serpas also says the two men who were considered as 'persons of interest' are now not considered to be suspects.
Police believe it was Trung T. Le who fired the first shot.
Serpas says they are still trying to get information on the person who exchanged gunfire with Le.
Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Love isn't easy to find. Sure, it's a big world out there with hundreds of chance encounters and crossed paths every day. But the idea that one of those random people might be the one that you are going to end up spending the rest of your life with… well, that doesn't seem nearly as likely. Or at least I didn't think so.
I had spent seven years in a relationship that had ended in heartbreak. I was almost done picking up the pieces, but wasn't quite ready to put myself completely out there again. That's when a friend recommended Match.com. At first, I was embarrassed about the idea of internet dating, but as a guy who worked at home and wasn't fond of bars, where else was I going to meet someone?
I signed up during a "free weekend" and was flooded with potential matches. Surprisingly, there was a glimmer of promise right away – a shared interest here, a cute profile picture there – but I knew I would have to weed through a lot of near-misses to find a hit. But at least it was a start…
Flash forward to six months later. I had talked to a bunch of matches. I had gone out on dates (even a few second dates). But I hadn't found love. This time, I wasn't settling for "close enough."
Unfortunately, my Match.com subscription was about to expire… and I was going to let it. I was about to chalk this up as a failed experiment. That's when I got one of the most important e-mails of my life.
Match.com knew I hadn't met "the one", so they were offering me an additional six months for free. At the time, it felt like something between a promotional tactic and an admission of failure, but I realize now that it was a vote of confidence from the folks at Match. You all were certain that someone was out there for me and they were determined to help me find her. And you did.
Soon after, a potential match popped up in my Daily 5: Red headed Jessica. I instantly knew I should reach out to her.
A year later – almost five years to the day after our first date – we got married on a rooftop in downtown Cleveland while our friends and family celebrated alongside us. It was the best day of my life… and the only proof I'll ever need that Match.com really works.
I never imagined that a "free weekend" on an internet dating site would help me find love. I signed up to Match.com hoping to find someone cool to date. You all lived up to that end of the bargain, but managed to do so much more. You managed to find my best friend. The love of my life. The person I want to grow old with.
If you ask me, that's worth any price…
Marc & Jessica
Married September 9, 2012


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VICTOR ESPINOZA, TEDDY'S PROMISE, Winner "When she wants to run, she's excellent. If I would have asked her to go early, she would go, but I didn't want to do that. For such a long time off and five furlongs I wanted to take her back and make one run. It worked out perfect. I didn't want her to be too aggressive. I just let her come out of the gate and do whatever she wanted to do.
GARRETT GOMEZ, RUMOR, Second: "It was a good comeback race for her. She rebounded and she's back on form. Hopefully, she'll have a good summer. I tried to be real patient with her because I understood what happened last time (bled). I let her kind of find her way the best as possible, stay out of her way and let her do her job."
RON ELLIS, TEDDY'S PROMISE, Winner: "She ran awesome. I like the way she did it, sitting off the pace. She's been a tough filly to get to relax and she took another step today. We planned on running in the three-race series; this, the ($70,000-added) Desert Stormer Handicap (at six furlongs June 17) and the ($200,000 Grade II) A Gleam Handicap (July 14). It builds up nicely to that seven furlong race.''
RICHARD MANDELLA, RUMOR, Second: "I'm happy to have her come back like that. She did not run well in her last race and bled. It was a one-time thing, she never had a problem with it before and hasn't since. I'm glad to see her come back well and we'll probably point her to the A Gleam."
Copyright © 2009-2012, Hollywood Park. All rights reserved.


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Pacers win big over Mavs
Paul George and Indiana Pacers went on an offensive surge in the third quarter to sink the Dallas Mavericks.
However, all Pacers coach Frank Vogel could talk about was his top-ranked defense.
George had 24 points and eight rebounds and the Pacers broke open a close game in the third quarter to beat the Mavericks 103-78 on Thursday night.
With the game tied at half, the Pacers outscored the Mavericks 34-17 in the third. George had eight points in a 20-5 run to open the second half.
Vogel said his team's defense allowed Indiana to pull away in the second half.
"Our defensive effort keeps getting better and better," Vogel said. "I'm very impressed with how dialed in our guys are and how disciplined they're playing on the defensive end."
The Central Division-leading Pacers won their fourth straight and have a half-game lead for the second-best record in the Eastern Conference.
Indiana is 2-0 on a four-game Western Conference trip. The Pacers beat the Houston Rockets 100-91 on Wednesday night.
"It was great win," George said. "For us to come out and match their same intensity was huge, especially on their floor."
Dirk Nowitzki scored 21 points for Dallas, which remained 1 1/2 games behind the Los Angeles Lakers in the race for the final playoff spot in the Western Conference.
"Having a dud like this on our home floor is definitely disheartening," Dallas center Elton Brand said.
Nowitzki and five of his teammates have grown out beards since early February and vowed not to shave until the Mavericks (35-37) got back to .500.
Those unshaven Mavericks will have to put their razors away for at least a few more days as Indiana denied Dallas a chance to even its record for the first time since Dec. 12.
Pacers center Roy Hibbert didn't want the Mavericks to pull out the clippers just yet.
"We heard something about them wanting to shave or doing something like that," Hibbert said. "We wanted to shut that (stuff) down to begin with. They wanted to get to .500 so they gave us their best effort in the first half. Whatever gimmick they need to rally themselves, that's fine."
Hibbert had 16 points and 11 rebounds one night after scoring a season-high 28 against Houston, and Tyler Hansbrough added 13 points and nine rebounds off the bench for Indiana, which announced before the game that former All-Star forward Danny Granger will have season-ending left knee surgery.
David West scored seven points in his return for the Pacers after missing six games with a lower back strain.
The Pacers outrebounded the Mavericks 55-34 and scored 15 second chance points. Dallas suffered its 11th loss of 20 points or more this season.
"It was a wipeout for us as far as the rebounding," Mavericks coach Rick Carlisle said. "That's been a challenge for us."
George Hill hit a 3-pointer to start the second half and break a 41-all halftime tie.
George hit a 21-footer to push Indiana's lead to 49-42. Indiana closed the 20-5 run with a couple of layups from Hill and a jumper from Ian Mahinmi to make it 61-46 midway through the third.
George scored 13 points in the third. He finished 10 of 17 from the field and had six assists and three steals.
Mahinmi closed the third with a dunk off a pass from Orlando Johnson as the Pacers outscored the Mavericks 34-17 in the third.
Vince Carter had 14 points and Darren Collison added 10 or Dallas. The Mavericks shot 38.6 percent (32 of 83) against the NBA's top-scoring defense.
Dallas, which got no closer than 10 points in the fourth, dropped to 3-2 on its six-game homestand. The Mavericks close out their longest home stay of the season Saturday against the Chicago Bulls, who ended Miami's 27-game winning streak Wednesday night.
NOTES: The Mavericks fell to 10-5 in March. … The Pacers have held 10 straight opponents under 100 points. … Justin Dentmon made his first appearance for Dallas after signing a 10-day contract Monday.


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Potential oil reserves are often treated as a state secret. This is especially true in Saudi Arabia, the world's largest oil producer. But soon, the cheap energy bonanza could be on the downturn, according to US State Department documents released by British newspaper The Guardian.
The documents, dated between 2007 and 2009, point to a phenomenon known to many as "peak oil," or the point of production where you cannot continue producing more, leading to a decline in availability and a spike in prices.
But far from being a mad prophet of doom, the US cables' source is not someone whose credibility is easily questioned.
His name is Dr. Sadad al-Husseini, the former head geologist in charge of exploration for the Saudi oil firm Aramco. He retired in 2004, but stayed in touch with US officials.
According to al-Husseini, Saudi Arabian reserves may be smaller than thought, even though the Saudis are on a growth cycle aimed at pumping out over 12 million barrels a day over the next several years. But, al-Husseini warned, global output would likely peak before then, and potentially starting in 2012.
"Our Mission now questions how much the Saudis can now substantively influence the crude markets over the long term," one of the cables noted. "Clearly they can drive prices up, but we question whether they any longer have the power to drive prices down for a prolonged period."
A decline in production in Saudi Arabia would likely send global oil prices soaring, with demand far outpacing supply.
"A series of major project delays and accidents XXXXXXXXXXXX over the last couple of years is evidence that Saudi Aramco is having to run harder to stay in place – to replace the decline in existing production," the document continued. "Additional production would likely come from increasingly heavy crude which the world lacks sufficient capacity to easily refine. The Saudis appear dis-inclined to discount its heavy crude sufficiently, so the market is dis-inclined to purchase it. In neighboring Iran, the regime is now purchasing floating storage for heavy crude which has no takers. While this Mission is far from embracing doomsday 'Peak Oil' theorists, Saudi Aramco's challenges are significant."
In another cable, al-Husseini argues that Aramco may have been overstating their potential for production all along — by the vast sum of over 300 billion barrels in "speculative resources."
"According to al-Husseini, the crux of the issue is twofold," the cable explains. "First, it is possible that Saudi reserves are not as bountiful as sometimes described and the timeline for their production not as unrestrained as Aramco executives and energy optimists would like to portray."
Another cable shows how, even in the world's wealthiest oil producing nation, concerns about potential output and catching up to other developed nations renewable energy technology has spurred innovation.
The document noted that Saudi electricity demand was expected to grow at 10 percent a year for the next decade. The consequence, it added, is that Saudi Arabia will have to constrain exports in order to drive up oil prices, allowing them to pay for doubling their electric grid capacity by 2018.


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An Evening with The Stars
Wow wow wow wow wow! What a night we had last night. My son and I were fortunate enough to have been invited to volunteer at the bowling night fund raiser for The Gift of Life Foundation. The Foundation was started by Everson Walls and Ron Springs to raise money and awareness for organ donation.
We were advised to get there early so we could choose our job. Well we were the first ones and man did we get the best job in the house! We worked the Celebrity sign in table. When we saw the list of who was coming, we could hardly wait until 6. It was only 3:30 so we had to keep ourselves occupied or the anticipation would have driven us insane.
Everson Walls and several members of the Springs family were there when we first arrived. Everson came by the table looking for some muscle to carry some boxes in. I asked JD if he would like to help Everson and he nearly tripped over himself. I didn't see him again until 6 rolled around because he was helping do all the guy stuff and making friends with everyone. It paid off for him later!
The first person we checked in was Tony Dorsett. He has several companies and sponsored two lanes. All of his offspring and his beautiful wife were with him. Tony looks like a million bucks and his eldest son Anthony looks like a movie star. A couple of guys came in after that and I had to ask them who they were unfortunately. Then they came in droves. It was overwhelming. Three guys sauntered up to the table together arms around each other and all I could think of is that I wished my mom was there to see these three. It was Roger Staubach, Billy Joe Dupree and Tony Hill. My night could have been complete then. They kept coming in so fast, so many stars (Mel Renfro, Drew Pearson, Robert Newhouse, Michael Downs, Doug Donley, Too Tall Jones, Timmy Newsome, Russell Maryland, and more) that I didn't really absorb what had just passed before me until later.
Once everyone had been checked in, we were able to mingle. It was really an awesome sight to see. All these pro athletes retired, and current players, gathering to honor Ron Springs and help raise money for those needing a transplant. But for me as a fan, I loved watching the reunion between them all. I loved seeing the young players like Tyson Thompson and Jason Hatcher paying respect to the retired guys. What a privilege this was to be such a huge Cowboys fan and see all these generations of Cowboys in the same place together, just being regular people and bowling, and visiting with each other and entertaining the fans that had paid to be there. This was a corporate thing. If a company made a sizeable donation, they were able to come and play with a celebrity.
Every person I asked to take a picture with JD was very kind about it. Tyson Thompson and Shawn Springs even stopped to talk to him a minute. They had all seen the kid working at the event and were thanking him for his help. Everson Walls was calling him by his first name and acknowledging him every time he saw him. What a class act Everson Walls is.
(My son with Everson Walls and Shawn Springs)
This was a wonderful event. I was so proud to be a Cowboy fan last night. I never asked for an autograph or picture for myself. I really didn't even think about it because my son was having the time of his life. Just as I had realized we didn't get any autographs and that we needed to head home, my son appeared with a football autographed by every Cowboy player that was there. These were for the corporate sponsors that had paid to be there. I am not going to rat anyone out for sneaking this football to him but let me tell you that it was the end to an evening most kids may never even dream of. My son the jock who thinks he is too cool to be excited was squealing. It was a night neither of us will soon forget. The Dallas Cowboys are a first class organization with a long list of first class players that treated us with such kindness last night. I wish all of you could have been there with us. We're still on cloud nine 24 hours later.
p.s. I copied the list of people I checked in and here are a few more that I didn't mention previously: JOSH HOWARD, KEVIN BURNETT, ERIC STRICKLAND, CORTNEY BROWN, MIKE JEFFERSON, JAKE REED, BIG TUCK, ISIAH ROBERTSON.


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Steve Smith has always been more of a throwback type than new-age diva when it comes to being an NFL wide receiver.
Steve Smith has always been more of a throwback type than new-age diva when it comes to being an NFL wide receiver, so it really shouldn't come as a surprise the guy actually still gets weekly visits from the milkman.
Now that's old school. Just when one may have thought milkmen disappeared about the same time as black-and-white TV sitcoms, leave it to a guy like Smith to get his regular calcium intake delivered to his front door.
It's all part of the master plan that has kept the 34-year-old at the top of his game long past the time most of his contemporaries have been put out to pasture. Smith was the 74th overall pick in the 2001 draft with Reggie Wayne and Santana Moss the only receivers currently in the NFL from that same class. Other receivers taken ahead of Smith included Chad Johnson, Rod Gardner and Freddie Mitchell.
Smith caught 73 passes for 1,174 yards last season, his 12th in the NFL, and in the years since missing an entire season with a broken leg in 2004 only Wayne (9,954) and Larry Fitzgerald (9,633) have totaled more than his 9,256 receiving yards. There's been little drop-off in his performance since being rejuvenated with the addition of quarterback Cam Newton in 2011.
"Here's my reply to if I've lost a step," Smith said. "If I've lost a step, that's good, that's great, it may happen or it may not, but what I'm doing at 34 there are general managers hoping and praying they can draft a guy that can do what I'm doing (right away)."
Smith overhauled his diet after reading an article during 2006 training camp promoting the positives of organic food, and that now includes frequent deliveries from a nearby farm.
"We actually have an old-fashioned milkman who comes every Thursday and all that stuff," Smith said. "It's just cleaner, no pesticides or any of that. After reading that report on the processing of food I went home from camp and cleaned out the whole pantry and went organic. Ever since then it's easier to keep my weight down and I just feel a difference and try to keep on that regimen. So much that I probably drive to Greenville every day for lunch to go to Whole Foods to keep myself together and that's healthier for me."
Smith also credits a "good gene pool" and relentless year-round workout routine that keeps both his mind and body at elite status. His mantra is never allowing oneself to get comfortable because that's when a lack of personal drive can begin to win the daily battle to be the best.
"You either are comfortable which leads to laziness or uncomfortable which leads you to work hard and treat every day as if it's your first day versus your last day," Smith said. "We're going to camp with 12, sometimes 13 receivers every year, even though some guys have repeated, in 10 years that's 120 guys who have sat in that seat and only a few of them that has remained and I'm one of those few guys.
"I don't say that to brag, I say that to sound fortunate, that I'm lucky, and I'm not going to roll the dice to say I've got this weekend off and not put in that preparation or that mental aspect. Also a big thing for me is being an example for my kids. How can I sit at home and tell them to work hard when I'm sitting on my butt playing video games and they never see me doing anything. That's part of the legacy I want to leave. A lot of people can say I did this, or I punched a guy, or I did that, but one thing you can never say is that I didn't work. I'm going to work."
Smith recently found himself in a reflective moment at home with his wife after his three children had gone to bed and began to think back on his career.
"Actually it hasn't gone by very quickly. Thirteen years has been phenomenal. I would've never thought I'd be playing in the NFL, first of all, or that I've played a decade-plus and that when I walk into the stadium, not just my family, but other people have my jersey. Going back home where I can go into a sports store and my jersey is there next to guys like Cam Newton and Luke Kuechly.
"For me I've treasured every moment of it. Maybe not as much as I should have, but I do appreciate it, and that appreciation goes into my preparation in the offseason that I have to work hard."


text:
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Joseph Nuttgens Fellow
Having previously worked for Patrick Reyntiens and John Piper, I reorganised my father's studio in 1982, since when I have undertaken many commissions, mostly for churches but gradually extending my ideas to include house windows and, more recently, exhibition pieces using steel sheet glass. In commissioned architectural work my chief interest is in 'daylight' but in my exhibition work I have been working with artificial light - hidden light sources, back lighting, reflected lighting and casting coloured light. The Studio, in the Chiltern Hills, is open to visitors by appointment.
The Studio – Piggots Hill – North Dean – High Wycombe – HP14 4NF
Tel:01494 56335
- 2006: Barry Bugden memorial window, St Peter's Church, Burnham, Bucks
- 2006: Tyneside Industrial Heritage window, St Mary's Cathedral, Newcastle upon Tyne
- 2003: East window, St Michael's Church, Halton, Bucks
- 1996-7: Durham Cathedral Millenium Window
- 1995: 5 light Lantern window for Sir Andrew Lloyd Webber, Symonton House
- 1994: window for Anglican/ Wesleyan Church. Putnoe Heights, Bedford
- 1988-92: north & south aisle & Lady Chapel windows for St Martin's church, Basildon, Essex
- Exhibition pieces: Sculptures in Light & Shadow using steel sheet, stained glass and halogen lights, exhibited Milton Keynes CBX & Aylesbury Museum & featured in Neues Glas & Perspectives


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|November 9, 2012, 12:57 PM
Join Date: February 6, 2012
Location: Spring, Texas
Posts: 94
Win. M100 autoloader in .308 won't fire.
My son-in-law inherited a Model 100 Winchester rifle from his father's estate.
It won't fire. I believe those rifles had a firing pin problem that was under recall at one time? He's a very busy guy and hasn't had a gunsmith look at it
yet. Anybody have one of these rifles? Does it need to be sent off somewhere or can most competent gunsmiths diagnose the problem and fix it?
I know it's hard to comment until we have someone look at it. Just wanted to know if someone knowledgeable about this model knew what common problems might be to blame.
He also has a lever action M88 .284 in excellent condition, original magazine stamped .284Win with the stock and bluing in nearly unblemished condition.
I haven't looked up the serial#s for dates of manu. for either gun. Don't know if it fires---don't have any ammo! Any info would be appreciated.
|November 9, 2012, 01:07 PM
Senior Member
Join Date: June 20, 2007
Location: Starkville, MS
Posts: 6,766
The firing pin problem was that the pin would break and the broken piece would jam in such a way as to cause it to go full auto. There is a good chance that yours is broken and the piece has already fallen out. Yes, you'll need to strip it down and get at the firing pin to determine if it is in fact broken.
Winchester (I'm talking about the corporation formerly known as Winchester) would send you a new firing pin and actually pay a small amount to have someone put it in. I don't know if the new corporation is taking responsibilty for fixing them or providing new pins.
First step is to get it stripped down to determine what the real problem is.
|November 9, 2012, 03:01 PM
Join Date: March 11, 2006
Location: Upper US
Posts: 18,663
it needs to go to GUNSMITH
But there is something you can do at home. You said it fails to fire, there are two different things that could be at work here. Either the firing pin is not being struck, or the pin is not hitting the primer. Your info doesn't let us tell which.
Dry fire the gun (make sure it is UNLOADED!!!). If the hammer falls, then the problem is most likely the firing pin. IF it doesn't, the the problem is something else, and probably more complex (like not being fully in battery, or a problem with the trigger group).
If the gun dry fires normally but fails to go off with live ammo, its likely the firing pin. Yes, there was a recall, because of problems with the firing pin. The model is long discontinued, but I think you can still get replacement pins.
If you are capable of disassembling the rifle, you can check the condition of the firing pin yourself, but if you aren't (and there's no shame in that), let a gunsmith handle it. 100s and 88s aren't common, and even gunsmiths will probably need to dig up some instructions before tackling the job these days.
The 100s and 88s were decent rifles, but not noted for being stellar accurate. Minute of Deer, or a bit better was the usual accuracy. Some individual rifles were better, some worse. Low sales volume (and the firing pin problem) led to them being discontinued.
They bring a fair chunk of change at the gun shows today, especially in .284, but that's due more to collector intrest than anything else.
All else being equal (and it almost never is) bigger bullets tend to work better.
|November 9, 2012, 06:43 PM
Senior Member
Join Date: July 5, 2010
Posts: 546
I had the firing pin recall thing done on one a couple years ago so it might be still going
|November 10, 2012, 09:08 PM
Senior Member
Join Date: October 9, 2009
Location: North Alabama
Posts: 6,510
+1 on the pin recall. Don't know if there is a current option or not.
But 100's and 88's can be shooters. My heirlom 88 sure is.
|November 12, 2012, 09:46 AM
Senior Member
Join Date: January 4, 2007
Location: pelican lake, WI
Posts: 258
If Winchester (new) does not honor the recall and you are half way mechanically inclined, you can replace the firing pin yourself. To romove the action from the stock: Remove the forearm screw and the trigger guard screw. Place the stock butt against your hip and pull and hold the charging handle all the way to the rear with your right hand. With the left hand tilt and lift the barrel and action out of the stock, while still holding the charging handle to the rear. Once the action is out of the stock you can get to the bolt to drive out the pin holding the firing pin in the bolt. Replace the firing pin and retain pin.
Winchseter 100's are great shooters if maintained and cleaned. I have several. My favorite is a M100 carbine which shoots 1" groups used each year for deer hunting. The others are closet queens. This is after bedding the action and shooting my hand loads. About four years ago I believe I posted here how to glass bed M100 actions. Gl;ass bedding has to be done in four steps, but is well worth it.
|November 12, 2012, 05:57 PM
Senior Member
Join Date: November 24, 2010
Posts: 351
Winchester will fix it no charge but some of the other info above isn't 100% correct. The old model firing pin would break and jam in the forward possition and then you get an out of battery slam fire when the bolt goes home on a live cartridge causing a " high velocity disassembly" that could include parts of your own body. As far as the full auto thing the first M 100's made had extra parts added that were supposed to prevent full auto conversion but it was found out that these extra parts can cause the hammer to fall without the operator choosing to do so. If you can't find a good shop to fix this you should send it off to
they have staff that know these inside and out
|November 13, 2012, 03:53 PM
Join Date: February 6, 2012
Location: Spring, Texas
Posts: 94
When firing--the trigger will pull, the hammer goes click but no round fires.
Plenty of flinching takes place when a live round is in battery! There is no light primer strike noted when inspecting cartridge after manual ejection. The bolt assembly must be in battery--it seems to slam forward and be in proper position when loading a round or when dry firing. I should be able to disassemble the rifle to inspect the firing pin. Stay tuned.
I believe this is a M100 carbine model as well.
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round 2 had a quite bit of vechile destruction happening aswell as the passing of a hero
space commando's
i move my cruiser up into the main battle zone
fire one! fire two! fire three!
i launched three missilesat the tank obliterating it just after a lucky role i know this is possibly the lowest thing to do but live with it alright
and still angry at the edf heavie's we slaughtered there hero
total cp-5
the trol'sadvance slowed by gate debriy they were outma.....i mean out outmatc.......i mean dea....doh put it this way they could't shoot at anyone(no they were dead sitting duck's)
total cp-0
edf a
enraged by there tank loss they mounted a assault on the cruiser it failed
total cp-1
edf h
the remaining rpg troop decided the troll car was good target practice obliterating it and the driver and gunner they then moved forward towards gate
total cp-10
(yes they now have enough for a wmd!)
the field so far
round 3 order's ready tobe received


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Peter Krisp is a commercial artist from Germany. He got his college degree as a display designer in 1970 and spent the 1970s working as a display designer, animator and communication artist. He started making cartoons and comic strips under the name Piiit Krisp in 1979. He was the main artist of books starring 'Lurchi', the mascot of the Salamander shoe factories, from 1979 until 1994. He worked initially in alternation with Georg Nickel and from 1989 on his own with writer Olav Sveistrup.
He has made comics and illustrations for the children's magazine Tabaluga and Benni by Sailer-Verlag from Nürnberg, as well as promotional comics for Ford ('F.O.R.D.', 'Ka-Comic' for Ford-Magazin), Verbraucher-Zentrale NRW ('Jupp') and Lux-Filter Express ('Henry'). His cartoons have been published all over the world, while he is mainly known in Germany for his comics and children's book illustrations (a.o. 'Papa Moll', 'Jan + Leo').


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Newport Pow Wow
17 August 2017
NEWPORT, R.I. (August 16, 2017) - Summer sailing and racing in Newport is at its seasonal high point and smack dab in the middle of it all, is the 2017 Melges 20 U.S. National Championship hosted by Sail Newport happening on August 17-19. Three days of competitive sailing will take place under the careful management of PRO Anderson Reggio and his legion of local sailing and race committee volunteers.
The U.S. National Championship is the second of two events scheduled in Newport for the Melges 20s and serves as the perfect opportunity for North American-based teams to warm-up and further prepare for the bigger, stiffer competition that awaits at the World Championship taking place in early October hosted by the New York Yacht Club (NYYC).
In attendance this weekend, in anticipation of the World Championship, teams from Australia, Japan, Russia, South Africa, U.S. Virgin Islands, and of course from the U.S.A. will be represented. Among them is Drew Friedes sailing PACIFIC YANKEE — the current leader of the 2017 Melges 20 World League, North American Division Ranking, Liam Kilroy's WILDMAN, Daniel Thielman's KUAI, Rob Wilber's CINGHIALE and Jim Wilson's OLEANDER.
A few equally strong European teams have made their way to the U.S. after competing at the European Championship in Sibenik, Croatia last month. Russia's Alexander Ezhkov's PIROGOVO, and Vladimir Prosikhin's NIKA are among the international early birds to arrive.
The fleet is thrilled to be welcoming a new Japanese team to the scene Tomatsu Aritomo at the helm of GIMLET.
The first warning takes place tomorrow morning, Thursday, August 17 at 1100.
Special thanks to goods provided by Farmer Willies Ginger Beer and BoatBrim.
Visit the Official 2017 U.S. National Championship Yachtscoring Event Website
View the Full 2017 U.S. National Championship Entry List
TOP FIVE 2017 MELGES WORLD LEAGUE RESULTS (After Ten Events)
1.) Igor Rytov, RUSSIAN BOGATYRS = 116 pts.
2.) Vladimir Prosikhin, NIKA = 72 pts.
3.) Achille Onorato, MASCALZONE LATINO = 64 pts.
4.) Krzysztof Krempec, MAG TINY = 62 pts.
5.) Rodney Jones, AUDI SUNSHINE COAST; 58 pts.
TOP FIVE 2017 MELGES WORLD LEAGUE, NORTH AMERICA RESULTS (After Two Events)
1.) Drew Freides, PACIFIC YANKEE = 37 pts.
2.) Igor Rytov, RUSSIAN BOGATYRS = 35 pts.
3.) Liam Kilroy, WILDMAN = 32 pts.
4.) Rob Wilber, CINGHIALE = 31 pts.
5.) Jim Wilson, OLEANDER = 29 pts.
2017 Melges 20 World League Results (After Ten Events)
Melges 20 on Facebook
Melges 20 on Twitter
Melges 20 on Instagram
Melges 20 on YouTube


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Diesel has launched their latest campaign; Diesel Island: Land of the Stupid, Home of the Brave. An interesting microsite concept to showcase items from their new range, on top of a pretty cool video the site takes you through the island's history (including a suitably stupid national anthem), island street view that manages to take you to a hot model with every click and you can interact with the island community by lodging new laws, and voting out things you don't want. (thanks Katy!)
To jump the border and become a citizen of Diesel Island, you just need to connect with Facebook to get started. Click here to check out the campaign or you can


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Grade(s): 9 / 10 / 11 / 12
Bill Nye is a man with a mission: to foster a scientifically literate society by helping people everywhere understand and appreciate the science that makes our world work. Nye has spent the past 20 years educating students young and old about science and understands the importance of keeping minds active after the last school bell rings. "Learning can happen anywhere and at anytime – the important thing is that it should never stop," Nye said. "We've put together fun, free and easy activities that will make this the summer of learning versus the summer filled with the dreaded words 'I'm bored.' " AN EARLY KNACK FOR HOW THINGS WORK Making science entertaining and accessible is something Bill has done most of his life. Growing up in Washington, D.C., he spent afternoons and summers de-mystifying math for his classmates. While working for Boeing in Seattle, Bill combined his love of science with his flair for comedy. After winning a Steve Martin look-alike contest, he became an engineer by day and a stand-up comic by night. Eventually, Bill made the transition to comedy writer and performer on Seattle's home-grown ensemble comedy show "Almost Live." This is where "Bill Nye the Science Guy®" was born. The 18-time Emmy Award-winning show appeared before Saturday Night Live and later on Comedy Central. During this time, he also wrote five kids' books about science, including his latest title, "Bill Nye's Great Big Book of Tiny Germs." BROADENING HIS MISSION Bill's passion for math and science translated into a love of space. His role as CEO of The Planetary Society, the world's large space interest organization, has taken him across the globe. And one thing Bill is very proud of is the MarsDials, two sundials on residing on Mars he created with Cornell scientists. America's favorite stand-up scientist hasn't changed much from that kid growing up in Washington, DC. He still rides his bike to work. He'll pull out his Periodic Table of the Elements from his wallet. And his drive for helping others understand science is as strong as ever.
I graduated from Illinois Institute of Technology with a Bachelor's Degree in Chemical Engineering. I received my teaching certification from Benedictine University in Lisle, Illinois in an accelerated math and science certification program. I started my teaching career at Thornwood High School in South Holland, IL. in 2006 and am still employed in the district. I currently teach general chemistry and AP chemistry. For the past three years I have been the Core Course Coordinator of my school which entails working with my chemistry colleagues to align our curriculum to the NGSS and to find innovative ways of modernizing our teaching methods. I have been using Sophia since the spring semester of 2013 and have been providing PD workshops on the use of Sophia to the teachers in my district. I am also a member of the Sophia Learning Teacher Advisory Board.
BA Biology Augustana College MS Environmental Engineering Illinois Institute of Technology Teaching Certification Calumet College
Some people may think that is overused phraseology, but anyone that knows me understands that it is one hundred percent true in my case. I have taught E.S.L. at language schools for ten years and taught High School English for 7 years. I have experience working with students from around the world. Please e-mail with contact information and I will get back to you quickly. Whether it's essay writing, preparing for STAAR exams, AP test practice, SAT/ACT preparation, or general study skills and classwork, our tutoring sessions can improve your grades and proficiencies in reading and writing.
Hi! My name is Nellie Wheeler and I am so regarded to join the Amazon astonishing Phd instructing Institute. This is an especially energizing time for me as it denotes my 4 year as an instructor. I moved on from the University of Cambridge in December and I couldn't be any more amped up for the chance to impart my enthusiasm for training to the understudies of Amazon astounding Phd instructing Institute.
Argentina, 32 años. Capital Federal. me dedico a la venta en una tienda online de ropa para chicas. Casada, estudio fotografia. amo la pintura y la musica


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TWITTER: @GeorgeRichards
Aside from a four-goal outburst on Tuesday, the Panthers haven't scored much lately.
It cost them again Thursday.
San Jose got rolling on a breakaway goal from Joe Thornton late in the second period en route to a 3-0 win at BB&T Center.
Despite giving up a few goals Thursday, few can blame goalie Tim Thomas as he's kept the Panthers in every game lately despite almost no goal support.
Thomas stopped the first 27 shots he faced before Thornton scored. San Jose's next two goals came after Thomas made the initial stop and the Sharks' pounced on the rebound.
Florida has scored one goal or fewer in five of the past seven games. Thomas has salvaged four points from three of those games.
"We weren't happy that they came and took it to us,'' Thomas said, "that they were the team ready to play and we weren't. .-.-. We were at home. They flew thousands of miles and it didn't look like it. They looked like the fresh home team and we couldn't get anything going.''
The Sharks, coming off a shootout win in Washington on Tuesday, had plenty of jump as they brought the house in the opening period.
San Jose had 21 shots on goal in the first yet couldn't get anything past Thomas as he rejected one shot after another.
The Sharks, who outshot Florida 21-8 in the first 20 minutes, didn't get their first goal until Thornton picked up a loose puck in front of Mike Weaver in the neutral zone and took off.
Thornton charged in on Thomas, going top shelf on San Jose's 28th shot of the game.
"We have to bury our chances and our opportunities,'' Scottie Upshall said.
Florida had shots but not many real scoring chances against rookie goalie Alex Stalock. One terrific chance came in the third when Tomas Fleischmann fed Upshall in front of the net. Stalock, who made 24 saves, made a terrific stop as he would record his first NHL shutout.
Moments after Upshall was stopped, San Jose charged up the ice and took a 2-0 lead.
Thomas made a nice stop on a shot from Tyler Kennedy yet was still sprawled on the ice when Matt Nieto followed up and pumped a shot into the vacant net at 4:44 of the period.
Midway through the period, Thomas made a kick save on Brent Burns that Joe Pavelski jumped all over.
"They certainly outplayed us,'' coach Peter Horachek said. "We weren't ready to play and I'm not very happy with that.''
Some of the Panthers' youngest players all scored during Florida's 4-2 win over the visiting Islanders on Tuesday night.
In the opening period, rookie Aleksander Barkov, Drew Shore and Nick Bjugstad staked the Panthers to a 3-0 lead.
"You're looking at the long term situation,'' Horachek said. "The future is one thing and now is another thing so as long as they continue to contribute right now where they are -- and they are -- we're okay.''
-- Florida's league-worst power play continues to shoot blanks. The Panthers went 0-for-3 on Thursday and has now gone scoreless on their past 27 tries.
The Panthers haven't scored a power play goal since Dec. 27 against the Red Wings.
-- The Panthers will hold an open practice Friday at the Coral Springs Iceplex at 11 a.m. before flying to Raleigh, N.C., to kick off a three-game trip.


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Sapphire HD 5570 1GB Review
With the recent introduction of ATI's mainstream graphics cards, more users will be able to take advantage of features such as DX 11 and Eyefinity, but the question is do these budget-friendly graphics cards have enough power to utilize all of the features they come equipped with? To answer this question, we will be looking at the HD 5570 graphics card from Sapphire. This card comes with 1GB DDR3 memory, a 128-bit memory interface, 400 shader cores and 16 ROPs. With these specifications, the HD 5570 seems to be a very capable card and it should be able to run most current games on the market - at least at low resolutions. Also, with the use of ATI's stream technology, this graphics card should be well equipped to handle smooth HD playback, as well as photo and video editing. One of the more interesting features of the HD 5570 is that even with all the technology and power packed into this card it is still a low profile design that only draws a maximum load of 45 watts. This could make the card very popular in the HTPC market and if the performance holds up, it could be a great choice for budget gamers. Of course, we will have to put it through our series of demanding benchmarks before a real conclusion can be drawn.
Closer Look:
The HD 5570 packaging comes in a red and black box with a style to it that looks similar to other products Sapphire has recently released. The front panel of the packing comes with Ruby aiming at her enemies with a futuristic looking blaster. Below her, Sapphire has listed some of the technologies that come standard with the HD 5570 graphics card. Each technology comes listed in its own box and are ATI Stream GPU processing, on-board Display port, CrossFireX™, and the 40nm die size. The front of the box also has the memory size and type listed near the top, with the graphics card name below it. The reverse side the box has listed features and specifications that the card offers, as well as a run down of how they are beneficial. Above these technology boxes is a sticker indicating the card comes with low profile bracket converters, SIM HD plug-in and 1GB DDR3 memory. The back panel of the box again has an image of Ruby, but this panel is also filled with useful information. Here you will find a run-down of features such as DX 11, CrossFireX and others. Sapphire has also included some images of the online awards they have received over the last eight years.
Once you have the outer sleeve off, you are presented with a plain cardboard box with a small recycling logo on the bottom left corner. This inner packaging is where graphics card and accessories are located and are securely held in place by the use of a extra cardboard insert inside the box. The graphics card comes wrapped in a anti-static bag with the drivers CD and installation manual laying on top of it. The accessories are also packaged here, but are located on the opposite side of the box.
The HD 5570 comes with only a few accessories which are a manual, driver CD, SimHD plug-in CD and two low profile bracket converters. There really is no need for any accessories beyond what is included though, as the graphics card has both a DVI and VGA port for connectivity. So, even without extra video adapters, there is still more than enough here to get you connect and ready to go.
Now that we have explored the packaging and accessories, we can start our more in depth look at the Sapphire HD5570.


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Spying and Secret Courts in America: New Rules and New Insights
Lee S. Strickland is a visiting professor in the College of Information Studies, University of Maryland; e-mail: firstname.lastname@example.com
If there is any issue that galvanizes the American public in general as well as the academic and civil liberties communities, it is the role and judicial supervision of intelligence in American life. Indeed, it is a concern that spans the centuries from our English ancestors to current citizens who experienced government excesses in the 1970s and remain concerned today, as government powers (authorities) have expanded in light of the war on terrorism with the USA Patriot Act of 2002.
Five hundred years ago English liberties were challenged by the court of the Star Chamber an entity of the state that began benignly and publicly but evolved under the Stuart monarchs so that, by the reign of Charles I, its name had come to symbolize arbitrary, secretive proceedings crushing personal rights and liberty with no right of appeal. And although our Constitution contemplates that our judicial process today is fully open to the public, our Congress has created a secret U.S. Foreign Intelligence Surveillance Court (FISC) to mediate the tension between our individual rights and the President's national defense authorities.
It was thus of great interest that on August 22, 2002, and for the first time, a lengthy opinion of the FISC in Washington was released to the public (see The FISC Opinion). Notably, it sheds detailed light on the practice of applying for Foreign Intelligence Surveillance Act (FISA) warrants, the sharing of the acquired intelligence information with criminal law enforcement authorities and the Administration's latest arguments as to the scope of certain USA Patriot Act authorities. What we see from the insights in this opinion are information management difficulties in past cases that have raised significant judicial concerns as well as a riveting political and legal debate today concerning the use of intelligence authorities by law enforcement. What we will decide as a nation is, quite likely, nothing less than the proper scope of intelligence in our democratic society.
The FISA Process and Problems in Brief
Readers will recall our previous Bulletin article (February/March 2002) that discussed the FISA and the changes effected by the recent USA Patriot Act. In brief, the FISA regulates the collection of "foreign intelligence information" (see Definition of Foreign Intelligence Information) from foreign powers or agents of foreign powers through a complex scheme of Attorney General (AG) approvals and in most cases applications to the FISC for secret warrants. The threshold condition for such warrants is not probable cause of criminal activity as with traditional Fourth Amendment law, but rather probable cause that the target is a foreign power or an agent of a foreign power. Thus, in light of the fact that FISA warrants can authorize electronic surveillance and physical searches and may be directed against both aliens and U.S. persons, the constitutional concern has always been that this process should not erode our basic rights under the Fourth Amendment.
It is this concern that led to the minimization requirements in the FISA and implementing AG procedures to constrain the acquisition and retention and prohibit the dissemination of non-publicly available information concerning U.S. citizens or permanent resident aliens if it does not concern "foreign intelligence." These procedures, however, specifically allow for the retention and dissemination of information that relates to terrorism or is evidence of any other crime that has been, is being or is about to be committed. Thus, this is the limited authority to share intelligence-acquired information in the United States with law enforcement authorities but also restriction that has heretofore prevented law enforcement authorities from having direct access to FISA files and from directing or otherwise controlling FISA investigations toward law enforcement objectives. If this were not the case, the easier-to-grant FISA warrants could become the norm for any criminal case having some "foreign intelligence" aspect.
In recognition of the important constitutional considerations at issue, the FISC has established a "wall" procedure for all FISA orders that requires (a) certification that the purpose is foreign intelligence, (b) disclosure of all criminal information aspects of an intelligence case including specifics on information sharing with law enforcement and (c) designation of a senior official to moderate the flow of information to law enforcement including the FISC itself in significant overlapping criminal and intelligence cases. Again, the purpose was "to preserve both the appearance and the fact that FISA surveillance and searches were not being used sub rosa for criminal investigations" and to prevent prosecutors from becoming "de facto partners in FISA searches." [FISC Order of May 17, 2002]. However, while these constitutional limitations and processes appear to many as clear and reasonable, the FISC over the last two years has had serious concerns about inaccurate FBI affidavits in FISA applications errors that have misled the Court as to actual law enforcement purposes and information sharing in at least 75 FISA cases. And, although the FISC directed the Department of Justice to conduct an investigation, no report was forthcoming.
The USA Patriot Act Changes and Attorney General's Implementations
Among the many changes effected by the USA Patriot Act and particularly relevant here, the basis for granting FISA orders was changed from foreign intelligence being the "primary" purpose to a "significant" purpose. Why this seemingly technical change? It reflects the reality that most terrorism investigations have both intelligence and law enforcement aspects and Congress wanted to ensure that the existence of a law enforcement proceeding would not legally imperil a continuing intelligence investigation. The Congress also took the related step of ensuring that information could be effectively shared between intelligence and law enforcement personnel. While the law had not really prevented such exchanges, a perception had grown among officials, as evidenced by recent statements and testimony by FBI officials, that there were significant limitations. Thus, the USA Patriot Act expressly authorized intelligence officers who are using FISA to consult with federal law enforcement officers and to exchange a "full range of information and advice. [See 50 U.S.C. §§ 1806(k) and 1825(k).] Together, the intent of these provisions was to reduce the conundrum between intelligence and law enforcement personnel as to the path of an investigation and to make clear that a FISA order could be obtained even if a criminal prosecution was contemplated or indeed had been instituted during the pendency of an intelligence investigation.
Few thought at the time of passage that these provisions would constitute a new grant of positive authority to law enforcement personnel but they did and led to the FISC order that is the subject of this article. Notwithstanding the concerns of the FISA Court as to inaccurate FBI submissions, the AG proposed on March 6, 2002, new FISA minimization procedures including giving criminal prosecutors access to all information developed in FISA cases and allowing criminal prosecutors to consult and provide advice and recommendations to intelligence officials regarding any intelligence case including the initiation, operation, continuation or expansion of FISA searches. The proposed March 2002 procedures are available at www.fas.org/irp/agency/doj/fisa/ag030602.html.
The increased sharing, as we have seen, is certainly authorized by the terms of the USA Patriot Act. The direct use of the FISA by law enforcement is, however, more problematic and is supported only by the Administration's argument predicated on the "significant purpose" change specifically, that the change contemplates dual intelligence and law enforcement objectives and hence dual use. Accordingly, a foreign counter-terrorism (CT) intelligence purpose can be met by the fact of a criminal prosecution for terrorism and hence such a criminal prosecution may make direct use of the FISA. The contrary argument is that the dual objective is correct but that FISA authorizes use only by intelligence officials and that use by criminal authorities eviscerates our Fourth Amendment rights requiring warrants based on probable cause of criminal activity.
In considering the proposed direction, the FISC approved the sharing provisions as provided by the USA Patriot Act but held that the direct use of FISA authorities by law enforcement officials represented a substantial and constitutional issue. Specifically, the court held that the AG directive would give criminal prosecutors a significant role in "directing" FISA investigations, would violate the statutory basis for FISA orders (intelligence purpose) and would effectively substitute the FISA for the Fourth Amendment. Accordingly, the FISC revised the proposed AG procedures in part to allow the new levels of coordination and sharing but to retain the critical aspects of the "wall" that precludes direct use or control of FISA authorities by law enforcement personnel. Hence, to be maintained for the moment is the "bright line" between criminal and intelligence investigations and the rights of U.S. persons under these two bodies of law.
What Do These Developments Mean for Us as Citizens and Information Professionals?
First, for the moment, we preserve Fourth Amendment values while still allowing the most effective intelligence and law enforcement operations. In no manner does the FISC order compel the United States to be impotent in the face of terrorism. Intelligence and law enforcement investigations of the same target can proceed in tandem with full coordination and sharing. If and when critical information is developed either through intelligence or law enforcement efforts the United States can employ a panoply of tools to act against the danger presented. If there is sufficient evidence of terrorism or other U.S. crime, a prosecution can ensue and, if there is not, deportations and/or foreign prosecutions are all available options. These limitations simply mean that criminal prosecutors may not freely use the FISA process in lieu of established constitutional search and seizure process.
Second, we must be prepared to join in the continuing legal and political debate over the proposed procedures. On August 23, 2002, the Department of Justice appealed this decision to the special three-judge court that was created to review FISC decisions. This court the U.S. Foreign Intelligence Surveillance Court of Review has not met previously and consists of three federal appellate court judges appointed on a rotating basis by the Chief Justice. A decision is pending at the present time and further review is also available by the Supreme Court. And, irrespective of the final judicial decision, there will be further political action. In one of the more unusual aspects of this controversy, the Government brief on appeal (available at www.fas.org/irp/agency/doj/fisa/082102appeal.html) asserted that Senator Leahy, identified as the "drafter of the coordination amendment" in the Patriot Act, "had agreed" that there is no longer a distinction between using FISA for a criminal prosecution and using it for foreign intelligence collection. But in a statement on September 10, 2002, in the context of a Senate Judiciary Committee hearing, the Senator clearly renounced the assertion that he supports the Attorney General's position:
That was not and is not my belief. We sought to amend FISA to make it a better foreign intelligence tool. But it was not the intent of these amendments to fundamentally change FISA from a foreign intelligence tool into a criminal law enforcement tool. We all wanted to improve coordination between the criminal prosecutors and intelligence officers, but we did not intend to obliterate the distinction between the two, and we did not do so. Indeed, to make such a sweeping change in FISA would have required changes in far more parts of the statute than were affected by the USA Patriot Act . . . [and] such changes would present serious constitutional concerns.
And, perhaps beyond the legal debate, another question is presented the practical necessity, not to mention the political wisdom, of the proposal. It is not at all clear why full sharing and coordination is insufficient, why this authority is truly needed and why we should as a nation detract our attention from the real challenge of terrorism with a perceived threat to civil liberties. In sum, perhaps the proposal harms U.S. interests by eroding public support for the counter-terrorism mission.
Third, we must plan in our businesses for the possible receipt of FISA orders since this debate does not affect the basic availability and terms of such orders. Information-centric institutions schools, libraries and Internet service providers will continue to receive secret FISA warrants and recipients will be barred from disclosing the terms. Of course, this does not mean that recipients are prevented from fully disclosing the fact and content to management, directors and legal counsel for their institutions. A more open question is whether recipients may disclose the simple fact that their institutions have received one or more FISA warrants; authorities are mixed but the weight tends to support the right to make this very limited statement.
And fourth, we should consider whether information exploitation tools more than problematic legal arguments could best facilitate the effectiveness of dual law enforcement and intelligence cases. For example, would visualization tools allow us not only to understand the data better but also track the originating interests and the using interests? Would time series analysis tools allow much the same tracking but include the ability to understand how information builds a case? And lastly, would not commercially available collaborative tools provide a mechanism to share and also track information relevant to multiple cases? Such tools could provide an operational benefit not only to concerned government officers but also to the FISC and government managers to ensure their appropriate oversight and adherence to minimization requirements. In sum, many of the errors of the past that greatly concern the FISC and limit investigative efforts today, might be ameliorated by the judicious application of information technology.
The FISC Opinion
The opinion was released by the Senate Judiciary Committee having received it from the FISC in response to a committee inquiry dated July 31, 2002. The committee has been examining how the FISA is working in practice and specifically considering the Department of Justice requests for investigative powers beyond those granted by the USA Patriot Act. A copy of the opinion is available at www.washingtonpost.com/wp-srv/onpolitics/transcripts/fisa_opinion.pdf as well as www.fas.org/irp/agency/doj/fisa/fisc051702.html.
The Definition of Foreign Intelligence Information
The FISA defines foreign intelligence information as information about (1) an actual or potential attack or other grave hostile acts of a foreign power, (2) sabotage or international terrorism by a foreign power or an agent of a foreign power, (3) clandestine intelligence activities by a foreign power or agent or (4) a foreign country that is necessary to the national defense or the security of the United States or the conduct of the foreign affairs of the United States.
Copyright © 2003, American Society for Information Science and Technology