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The essential conference for pharmaceutical and medical device professionals covering advances in technology for pens, auto-injectors, large volume pumps, patch pumps, needle-free, pre-filled syringes and other parenteral methods – plus a regulatory update
21-22 Mar 2019
The pharmaceutical industry and its main markets continue to change. Geopolitical changes influence healthcare industry funding models, demographic changes (in developed countries) increase the demand for healthcare and technology advancement opens up new opportunities. In drug delivery we have witnessed a very significant transition. For many years oral tablets held the leading market positions. For example, at one time oral H2 receptor blockers were the blockbusters. These were replaced by proton pump inhibitors and then cholesterol lowering drugs as the world's biggest sellers. Today, depending upon which list you look at, around 9 of the world's 12 best-selling drugs require a drug delivery device, as they are biologics for parental delivery or drugs for treatment of asthma, requiring an inhaler.
Injection devices to deliver the latest generation of drugs are evolving. First generation devices were typically mechanical and functioned only to get the drug into the body. Increasingly, in next generation parenteral devices, the drug delivery device is recognised as the interface between the drug and the patient. It can offer many features and functions which improve usability, safety, efficacy and compliance, plus many other functions beyond such as connectivity and diagnostics.
This conference looks at the latest trends, technologies and applications.
Please note we are also running:
This meeting runs back-to-back with Pre-filled Syringes on 21 March 2018 and there is a further Sandal Aldo Gold Women's Polesia Dress £200/€280 discount when booked together with this programme.
To find out more call Customer Services on +44 (0)20 7749 4730 or e-mail firstname.lastname@example.com
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Exhibition opportunities are available. Please contact Customer Services on +44 (0)20 7749 4730
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This conference will be of particular interest to:
Scientists and management in medical devices, pharmaceutical and biotechnology companies working in parenteral delivery. Personnel responsible for device programmes, product development, regulatory affairs and product lifecycle management will find this event beneficial. Previous delegates include: Directors, Senior Executives in R&D, Head of Device Departments, Combination Products Specialists, Drug Delivery Managers, Business Development Executives, Product Development Managers and those in Project Co-ordination and Marketing roles.
THIS IS THE 2018 PROGRAMME THE 2019 PROGRAMME WILLLyla elephant Ankle Poms Fix Womens The grey Bootie aPv1CC BE AVAILABLE IN DUE COURSE
Chairman's welcome and introduction
Dr Greg Berman, Independent Consultant, UK
Trends in Injection Devices
Mark Chipperfield, Company Director and Principal Consultant, Corvus Device, UK
Latest devices – connectivity with injectables
Markus Bauss, Managing Director, SHL Group, Germany
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Ian Thompson, Vice President Business Development, Ypsomed
Connected health – getting to market with an electronic auto-injector, app and cloud services
Neil Williams, Director, Front-End Innovation, Head of Connected Health, Medicom Innovation Partner, UK
Pre-filled syringes over time
Andreas Rothmund, Dress Polesia Women's Sandal Aldo Gold Qualified Person, Vetter Pharma-Fertigung GmbH & Co KG Germany
Using polymeric PDC technology to improve auto-injector design
Jonathan Bradshaw, Device Development Engineer, Oval Medical Technologies, UK
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Ian Wands, Market Development Specialist, DuPont Performance Materials, UK
Large volume injectors: one device – multiple solutions
Mike Hooven, CEO, Enable Injections, USA
Networking drinks reception
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Review of day one
Dr Greg Berman, Independent Consultant, UK
What do pharma companies want from devices?
Dr David Jefferys, Senior Vice President Global Regulatory, Government Relations and European Product Safety, Eisai Europe Ltd, UK
The EU regulatory framework for injectable delivery systems
Stephen Dew, Associate Director RA (CMC) Combination Products, Biogen, UK
US regulatory considerations for injectable delivery systems
Suzette Roan, Senior Director, Global Regulatory Affairs, Sanofi, USA
Advances in Needle Free Drug Delivery
Andrew Coats, Director of Engineering, Portal Instruments, USA
Enhance existing devices or move to brand new integrated solutions? Two approaches for smart pen injectors
Arnaud Guillet, Business Development Associate, Bicorp, France
Human factors in injectable drug delivery
Greg Thay, Polesia Women's Sandal Gold Aldo Dress Human Factors Director, Medical Devices,Thay Medical, UK
Key training device considerations for injection based therapies
Joe Reynolds, Research Manager at Noble, UK
|21-22 Mar 2019
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Ring Lardner Jr., the Academy Award-winning screenwriter who was imprisoned for refusing to answer questions before the House Un-American Activities Committee, has died of cancer. He was 85.
The last survivor of the so-called Hollywood 10, a group of blacklisted writers, directors and producers who went to prison for refusing to testify about their political beliefs, Lardner died Tuesday in the arms of his daughter, Katharine Lardner, at his home in New York City. His wife of 54 years, Frances Chaney, was at his side.
The other members of the Hollywood 10 were Alvah Bessie, Herbert Biberman, Lester Cole, Edward Dmytryk, John Howard Lawson, Albert Maltz, Samuel Ornitz, Robert Adrian Scott and Dalton Trumbo. Of the 10, only Dmytryk finally named names of suspected Communists.
Those who knew him marveled that the tall, aristocratic Lardner, the last surviving son of the legendary baseball writer and short-story author Ring Lardner, managed to weather the turbulent blacklist period without bitterness.
"A number of the Hollywood 10 just never recovered," said Stefan Kanfer, whose book, "A Journal of the Plague Years," revisited the blacklist era. "It seemed to me he [Lardner] was the least bitter of any of them. Ring remained a liberal, but not a Communist. He discarded all that '30s garbage and went on with his life."
Lardner, who with Michael Kanin won an Oscar in 1942 for collaborating on the screenplay for the film "Woman of the Year," was not officially credited for his work over a 17-year period until his screenplay for "The Cincinnati Kid" in 1965. In 1970, he won another Oscar for "MASH.
10 Months in Prison
His defiant appearance before the House committee in October 1947 led to his imprisonment and blacklisting. When asked by Committee Chairman J. Parnell Thomas if he was then or had ever been a Communist, Lardner replied, "I could answer that question the way you want, Mr. Chairman, but if I did I'd hate myself in the morning."
Enraged by that response, Thomas ordered Lardner removed from the hearing room.
Lardner, who belonged to the Communist Party but believed that it was no one's business, was cited for contempt for failing to cooperate with the committee. That led to his indictment and one-year jail sentence in 1947. After court appeals failed, Lardner served 10 months at the Federal Correctional Institution at Danbury, Conn.
"In prison I started working on a novel, which I got published a couple of years after I got out," Lardner recalled years later. The novel was "The Ecstasy of Owen Muir."
"Although it didn't make a lot of money or sell well, it was something I was very proud of having written."
Blacklisted after leaving prison, Lardner was forced to work underground or in Mexico and London writing films and television episodes, using various pseudonyms. Some of those screenplays included "Virgin Island" (1959), "The Cardinal" (1963) and the ironically titled "A Breath of Scandal" (1960). Last August, the Writers Guild of America corrected the credits of eight blacklisted writers from the 1950s and 1960s, crediting Lardner and Hugo Butler for "The Big Night," a 1951 film starring John Barrymore Jr.
In 1988, at 72, Lardner conceded that his was a blind and youthful allegiance to the American Communist Party, which at the time seemed "a cure-all for mankind."
No country, he said, "that has become Communist or socialist has been able to avoid some form of dictatorship. Theoretically, it's possible, but it becomes something less desirable in practice."
He later took a more philosophical view of his fate.
"I certainly don't regret what I did," he said. "You can't say what your life would have been if it had gone in a different direction; there's only the one direction it did go."
Born Ringgold Wilmer Lardner Jr. in Chicago in 1915, Lardner had three brothers--James, David and John, who all became writers. Unlike him, they all died relatively young.
Ring Jr.'s first byline appeared in 1919 when he was 4. It was on a travel story entitled "The Young Immigrunts," and it was actually ghost-written by his father. The story described the family's anxious cross-country journey by car.
When Lardner was a boy his family moved to Great Neck on Long Island. Family friends there included journalists Grantland Rice and Heywood Broun and celebrated writers Dorothy Parker, H.L. Mencken and F. Scott Fitzgerald.
In his 1976 memoirs, "The Lardners," Lardner said his father's affection for Fitzgerald and his wife Zelda made a strong impression on him as a young boy.
Ring Jr. knew and admired Fitzgerald again in Hollywood during the last few years of his life. But Zelda, he said, "left the deepest imprint."
"I have never known another adult, except my Aunt Anne, who seemed to say exactly what came into her head as it came," he wrote, "without any apparent exercise of judgment."
Larder enrolled at Princeton in 1932. Acting upon his father's lessons to distrust politicians and respect the interests of the oppressed, he became an active member of the Princeton Socialist Club.
He dropped out of the university two years later to see the world.
He sailed on a German ship to Hamburg and then proceeded by train to Leningrad and then back to Germany. "Everything I saw there, including a glimpse of Hitler and William Randolph Hearst in the back seat of a car in Munich, strengthened my impression that the best hope for mankind lay with the Soviets," he recalled in "The Lardners."
"Only in Russia were massive construction and planning for the future going on at a time when the West was either locked in stagnant depression or, like Germany, headed resolutely backward to barbarism."
James Lardner, a journalist and one of Lardner's five children, said his father was an impressionable 18 years old when he traveled to the Soviet Union in 1934 and became infatuated with Communism.
"It seemed like there was a lot of hope in the air [in Russia]," James Lardner said, "whereas in Germany he saw awful stuff and in America, he saw bread lines."
He noted that his father never wanted the United States remade along Stalinist lines and later tried to analyze why he didn't understand more fully the nature of Stalinism.
"What we did not do is act as spies for the Soviet Union," Lardner wrote in his memoir. "The Soviet government certainly had spies in America just as the American government had spies in the Soviet Union but about the dumbest thing a Soviet spy could have done--and the surest way to draw the attention of the FBI--would have been to join the Communist Party of the United States."
After returning to the United States, Lardner spent 10 months as a reporter at Hearst's N.Y. Daily Mirror before being recruited by David O. Selznick's film company. His first duties after arriving in Hollywood included rewriting scenes for "A Star Is Born."
In 1937 he was recruited into the Communist Party by writer Budd Schulberg. He began attending Marxist study groups and political meetings nightly. That same year he married Selznick's secretary, Silvia Schulman.
Later, he wrote in "The Lardners," Schulberg and his wife, divorced and married to other people, testified to Lardner's dismay as cooperating witnesses before the House committee.
After the Japanese attack on Pearl Harbor, Lardner, whose vision and questionable political affiliations disqualified him from the armed forces, worked briefly for the Army making training films on Long Island.
Back in Hollywood in 1942, he won an Academy Award for the comedy "Woman of the Year," which teamed Katharine Hepburn and Spencer Tracy for the first time.
Ominous Politics of Cold War
The war years brought hard news to the Lardner clan. His brother David, a correspondent for The New Yorker, was killed by a land mine in October 1944 while covering the war in Germany. He was 25. Another brother, James, a member of the Lincoln Brigade during the Spanish Civil War, had been killed in 1938 by a sniper. The 24-year-old James was the last American to lose his life in combat on Spanish soil. (His brother John died in 1960 at the age of 47 while working on an obituary of Franklin P. Adams for Newsweek magazine.)
Lardner and Sylvia divorced in 1945. About two years later he married actress Frances Chaney. By the end of their brief honeymoon, Cold War politics had developed ominously. No sooner had Lardner signed a contract with Fox for $2,000 a week and bought a large house near the beach in Santa Monica than a U.S. marshal was at his door with a subpoena to testify before HUAC.
Initially, there were 19, including German playwright Bertolt Brecht, who became known as "unfriendly witnesses," Lardner said, "as opposed to those who were willing and eager to tell the world what they knew about Communist subversion of the movie business."
They knew that if they answered the committee's first question--Are you now, or have you ever been a Communist?--they would be compelled to answer follow-up queries, including, "Who did you know in the party?"
In a strategy developed by Lardner and Trumbo, they adopted a tricky option.
"It was more reasonable, more principled and legally sounder, we argued," he recalled in his memoirs, "to refrain from answering questions or cooperating with the committee in any way on grounds that the 1st Amendment made the whole interrogation unconstitutional."
Jean Rouverol, the widow of blacklisted screenwriter Hugo Butler who has just written a book about those years called "Refugees From Hollywood: A Journal of the Blacklist Years," noted that when Lardner and the others appeared before the House committee, they also refused to plead the 5th Amendment against self-incrimination.
"The 5th Amendment implied guilt, so nobody took the 5th initially," she recalled. "It implied that they were ashamed of their political activities. . . . They all thought that standing on the 1st Amendment [instead] would keep them out of jail. It didn't. The Supreme Court refused to hear it."
At least 300 witnesses told the House committee everything they knew or suspected. Some named Lardner and others in the group as Communist subversives.
Lardner was fired by 20th Century Fox and placed on the Hollywood blacklist.
To the end of his life, Lardner never identified other Communist Party members, dead or alive.
"Dalton Trumbo once said that there were no heroes, only victims," Lardner said of the blacklist era in an interview for the book "The Hollywood Blacklist." "Maybe that was a little overboard, but in principle I agree with him. Some of the people who did testify were under very strong pressures and just didn't have any other ways of making a living. I sympathize more with the couple of hundred people who never did get back to work in Hollywood because they hadn't been well enough established before they were blacklisted."
In a telephone interview, his daughter Katharine recalled her father as "a class act, and funny."
"More than anything else, his goal was to live long enough to see his latest book, 'I'd Hate Myself in the Morning,' published," she said. "So a week and a half ago, my brother Jim and I surprised him with a copy and a bunch of balloons."
"Then I said, 'Hey, Dad. You're looking pretty good. How about a new goal?' " she recalled. "He thought about it and said, 'I want to see the reviews.' "
Katharine Lardner said she is writing a memoir that will deal with her father's life from her perspective as a child.
"Even as a kid, I felt nothing but pride for my father," she said. "When he was jailed for refusing to answer questions that were nobody's business, I felt he'd done an admirable and courageous thing. He fought for what was right."

subset: commoncrawl


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The arrival of good weather brings a greater chance of encounters with animals carrying diseases, an epidemiologist at San Juan Basin Health Department said Thursday.
Bari Wagner said rabies, West Nile virus, hantavirus, plague and Colorado tick fever are carried by animals and insects that transmit them to humans.
The health department has received five calls about possible exposure to rabies this year, she said.
A cat and a skunk were trapped in April and sent to the Colorado Department of Public Health and Environment for analysis, she said.
Both tests were negative.
Rabies can be transmitted by bites from dogs, skunks or bats, Wagner said.
In the last two years, 11 people in the health department service area have been urged to get anti-rabies vaccine.
Colorado has had three cases of hantavirus, in Weld, Delta and Garfield counties, Wagner said. None has been reported in Southwest Colorado, but people shouldnt let their guard down, she said.
A Montezuma County man died of hantavirus in October 2010 in his cabin near Mancos.
Hantavirus is found in the urine or droppings of deer mice, she said. Dried feces or urine can be stirred up in dust that, if breathed, can infect people.
The best way to protect yourself is to be careful when cleaning a summer cabin or working around a barn or wood pile, Wagner said. Those places are where deer mice, which carry hantavirus, are likely to be found.
Plague is carried by fleas, she said. A die-off of prairie dogs can signal that plague is a threat.
West Nile virus is carried by mosquitoes, and Colorado tick fever by ticks.
Wagner said people should protect themselves if they hike by wearing long sleeves and pants with long legs.


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Willie "Big Eyes" Smith Dies
Willie "Big Eyes" Smith Dies
GRAMMY-winning blues musician Willie "Big Eyes" Smith died Sept. 16 after suffering a stroke, according to his website. He was 75. Born in Helena, Ark., Smith was a longtime musician on the Chicago blues scene who taught himself how to play harmonica and drums and played with a number of blues giants, including Pinetop Perkins and Muddy Waters. Smith earned the lone GRAMMY of his career in 2010 for Best Traditional Blues Album for Joined At The Hip with Perkins. "Willie 'Big Eyes' Smith was a great, versatile Chicago bluesman who had a dynamic career as a vocalist, harmonica player and drummer," said Recording Academy President/CEO Neil Portnow. "The music he created made an indelible impact on the genre. Our sincerest condolences extend to his family, friends, fans, and all who will continue to appreciate his rhythm and riffs for generations to come." (9/16)
Nashville Music Council Gets New Name
The Nashville Music Council has been renamed Music City Music Council and has been reorganized to include a 21-member governing body, with Honey Hopkins appointed the council's director. The Recording Academy's Vice President of Member Services & Regional Management Nancy Shapiro has been named chair of the education committee. Founded in 2009, the Music City Music Council is a partnership between the mayor's office, the Nashville Area Chamber of Commerce and the Nashville Convention & Visitors Bureau and aims to capitalize on Nashville's identity as Music City. (9/16)
More Layoffs At WMG
Following a report earlier last week, Warner Music Group has cut approximately 25 employees across its field sales staff for its distribution division, WEA Corp. According to a Billboard.biz report, the cuts were made after the company began experimenting with an online ordering system in January. (9/16)
Adele's 21 Is Fastest-Selling Album Since 2005
GRAMMY winner Adele's 21 has sold 3.4 million units since its debut in February, according to Nielsen SoundScan, marking the fastest-selling album since 50 Cent's The Massacre sold 4.5 million through the week ending Sept. 11, 2005. Adele's 21 is also the bestselling album of the year to date, followed by Lady Gaga's Born This Way (1.77 million units), Lil Wayne's Tha Carter IV (1.18 million units), Mumford & Sons' Sigh No More (1.16 million units), and Jason Aldean's My Kinda Party (1.13 million units). (9/16)


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In sports, individual achievements can be gratifying, but for Lady Indians pitcher Felicia Pruitt the team victory meant everything…even more than a NO-HITTER?
Pruitt and the Lady Indians faced off against the Crystal City Lady Hornets at home Thursday and both dominated their opponent to the tune of a 10-1 victory.
Pruitt struck out 15 Lady Hornet hitters, twice striking out the side, on her way to a No-Hitter. She was named the Indian Sports Network Player of the Game. However, in the post-game interview the team victory was all she wanted to talk about.
When asked about the no-hitter Pruitt said "the team win is what matters."
She's right it was a team victory. The offense put 10 runs on the board with a combination of speed and timely hitting and the defense behind Pruitt was outstanding making some very hard plays look easy.
"Flea (Pruitt) kept the ball away from the hitters well," said Head Coach Trudy Bull. "She had them guessing by moving the ball around and hitting her spots. Even on her walks she hit her spots, they just didn't bite."
Pruitt also commented on what was working for her "I was throwing my rise ball pretty well."
For more on this and other stories pick up your copy of The Elsberry Democrat today from one of our several locations. You can also sign up for the online edition by visiting http://elsberrydemocrat.com and clicking on Subscribe …


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text: Providence Health & Services is committed to providing high quality health care programs throughout Oregon, and our laboratory services are no exception. Operating 24 hours a day, our fully accredited labs process more than five million diagnostic tests annually statewide. With experienced protocols, the latest technology and skilled medical staff, you can trust us to quickly and accurately deliver the results you need.


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Share This Review
At first glance you might think you've heard this one before: You may be thinking Body Heat or The Postman Always Rings Twice, and you would be partly right – but partly wrong – oh, so wrong.
One very minor problem I had with the book is that some characters tended to "slip out of character" at times. Jared is supposedly thirty-something but when he injects social commentary lamenting the "good old days" he sounds like a much older guy. Also his reporter buddy Mickey Thompson is described as "…an aging yuppie, a product of boarding school, and an old school preppie." But he sounds strongly blue collar/working class.
The main problem I had with this story is that the protagonists are not the least bit likeable or sympathetic and seem to be seriously lacking in any form of a conscience. That made it hard for me to care too much what happened to them. My first impression of Katherine was, "Gold-digger" and each new revelation about her only left me thinking, "Yep, gold-digger."
Jared didn't win any sympathy from me because he was too much of a sap. Okay, Katherine is supposedly mind-boggling beautiful and the opening chapters emphasize that Jared is head-over-heels about her. But before the ink has dried on her divorce decree she enlists Jared's aid in a plot that would knock the rose-colored glasses off of any rational person. It takes the barest minimum of persuasion to get Jared onboard. Katherine never threatens or harasses him. The two haven't become physically intimate yet. The only "seduction" she applies is a quick tongue darted in the ear and an occasional squeeze on the kneecap. Like I said, what a sap.
In a later revelation she portrays her husband as a monster and herself as a victim of sexual exploitation in order to gain Jared's sympathy. However, she appeared to be all too willing to be exploited. Why? For money of course. And this sad story is told while she's still living in her ex's cushy Park Avenue apartment (until she can find her own place) drinking very expensive champagne with her new lover.
And if nothing else should give Jared pause – should scare the socks off of him, actually - it turns out that Katherine has an unnatural affection for guns. But then it occurred to me that this guy has been drinking non-stop throughout the first half of the story so maybe that better explains his astonishing lack of judgment.
In the second half of the story the author goes all Tom Clancy and takes a grave situation (a murder plot) and kicks it up ten or twelve notches; I honestly did not see that coming. Suddenly there were so many plot twists and turns I had to throw up my hands unsure what to believe or who the good guys or bad guys were.
Although I never warmed up to Katherine, she is the strength of this story. I thought it was very clever how the more intimate she becomes with Jared and the more she reveals about herself, the less you feel you know her. Once the plot kicked into high gear, I wasn't even sure if her name was Katherine.
Manhattan Affair could have benefitted from more sympathetic characters, but I'm giving it three out of four stars because of its element of surprise and level of complexity.
Buy "MANHATTAN AFFAIR" on Amazon
Buy "MANHATTAN AFFAIR" on Barnes and Noble


text:
CINCINNATI (AP) -- Within months of being awarded a $1 million casino prize, a Cincinnati man got busted for drugs and went broke.
Kevin Lewis, 52, received the money through a Horseshoe Casino giveaway last summer. Lewis told Hamilton County court officials on Wednesday that the money was gone, much of it to paying bills for other people, The Cincinnati Enquirer (http://cin.ci/1l5BcAv ) reported.
Common Pleas Judge Jerome Metz Jr. sentenced Lewis to three years of probation for his guilty pleas to drug possession and trafficking. He was arrested in December on charges of trafficking marijuana and painkillers. He could have been imprisoned for more than five years. Prosecutors dropped two of four counts in a plea agreement.
"I regret what I did," Lewis told the judge. "But I take full responsibility."
His attorney told the judge that Lewis was left disabled and hooked on painkillers after 2012 hip surgery. But the judge noted that Lewis had earlier drug convictions.
Besides probation, Metz ordered Lewis to get his high school equivalency degree and submit to drug and alcohol testing. He also suspended his driver's license for two years.
Attorney Alvertis Bishop Jr. said Lewis had worked in inventory control for a downtown Cincinnati hotel before a hip replacement.
Information from: The Cincinnati Enquirer, http://www.enquirer.com


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Red carpets are always so great to style and trend watch on your favorite celebrities. Award shows like the CFDA Awards (the Council of Fashion Designers of America) are even better because they bring the best of the best when it comes to fashion. The most stylish celebrities, the hottest designers, and the sexiest models all walk the red carpet at this annual event. So many stars were on point with their red carpet fashions this year, it was hard to select our favorite trends. But a few definitely stood out- so here they are.
Whoever said "a little sparkle goes a long way" clearly hasn't taken a look at these beautiful women. Head-to-toe sparkle commands attention and adds a glam-factor to an otherwise basic dress. Take the trend over to your luxury swimwear with high-quality gold hardware such as the chain detailing on the She's Got A Way bikini and the Sipping Pretty bikini by Lady Lux. You'll be the one commanding people's attention while walking past poolside.
White can be a difficult color to pull off, which is why it seemed to be the color of choice for the supermodels at the CFDA Awards. When done right, however, white can look truly breathtaking and regal. If you're not willing to commit to an all white gown that leaves little room for error, agree to smaller portions of white- such as on your designer swimwear. Truly, Madly, Deeply is a basic white bikini with beautiful gold detailing at the shoulders. Accessorize with gold jewelry to match and you'll be ready to strut your stuff just like the goddess-like supermodels on the red carpet!
Cutouts seem to be a trend that just doesn't want to die. It's been huge all through spring and it's starting to transition just as strongly into summer. It's a great option if you want to add sex appeal to your look without being obvious. That concept is similar to swimwear. If you're looking for a sexy option without being too obvious or revealing, try a monokini! The cutouts follow the hot trend that we're seeing so often on the red carpet. With options like Love Bound, Heaven Can't Wait, and Drive Me Wild- there's sure to be something that suits your style!


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Violin's data-slurp flash SAN frontend to cram box at furious speeds
Force 2510 from Santa Clara
Violin Memory is now accelerating disk-drive array-based SANs by using a flash front-end caching box, which also sucks data off the SAN and stuffs it in Violin's own 6000-series flash arrays.
The Force 2510 is called a "memory appliance" in Violin's cant and is the company's implementation of the GridIron Turbocharger appliance, Violin having acquired GridIron in January this year.
The idea is, like Avere's filer accelerating FTX appliance, to place a flash-based cache inline in front of a Fibre Channel-connected SAN array, meaning legacy block-access disk drive array, and put the hot data dynamically - powered by hardware-accelerated Bayesian profiling algorithms - into the cache so accessing servers get it much quicker. The caching algorithms "predict application access patterns in real-time to ensure that most of the reads are serviced" by the Force 2510. The acceleration hardware uses FPGAs.
From a well-briefed blogger we understand that it will "speed up I/O not just by caching data that's active, but by learning what other clusters of data in a similar locality may also become active and bringing it into the appliance."
All in all, this can mean up to 90 per cent of SAN reads are serviced from the 2510, which speeds data access by up to ten times – and that cacheing works quickly, rather than having to wait hours for some tiering algorithm to learn what's hot and what's not.
All write I/Os and status commands are passed through to the back-end SAN and the 2510 can cache write data as well as read data..
Violin has an extra wrinkle: while this is going on the clever little caching box can also copy data from the disk drive array and stick it into one of Violin's 6000-series flash arrays, so that it all gets served up from flash instead of just the hot data you need right now. Additionally, its storage takes up less physical space, draws less power, and needs less cooling - the three classic flash array advantages.
Violin's marketing bumf says: "Hardware optimisation built into Force enables the Maestro software to migrate multiple TBs of data every hour."
It is a migration box as well as a cacheing box. As SAN data is transferred to a 6000-series array then it can be accessed there (more quickly) than from the backend SAN array.
The Force 2510 is a 2U rackmount box, and has a cache-coherent, active-active, dual controller setup for high availability, 192GB of DRAM and 8TB of flash. It has four server-side and four SAN-side 8Gbits/s Fibre Channel ports and two Ethernet interfaces for management. The two controllers are linked with dual 10Gbit/s Ethernet ports for high-availability failover and failback. The maximum bandwidth is 4GB/sec and the minimum latency is under one millisecond. It supports VMware's VAAI array integration product.
The Maestro Memory Suite is the software that runs the box.
Violin Force 2510 memory appliance
According to Violin, the system supports: "All legacy storage arrays, including EMC, HP 3PAR, IBM, Hitachi, Dell, Fujitsu and NetApp arrays," and all the leading Fibre Channel switches from suppliers Brocade, Cisco and QLogic. It can be installed inline between the SAN array and accessing servers, and functions as a transparent Fibre Channel proxy device. The accessing servers and back-end SAN array don't know it's there; data just gets to the servers faster.
A third string to the 2510's bow is data protection. "Hardware-accelerated algorithms implemented in the Memory Service Engine enable asynchronous high performance data mirroring between multiple Violin Memory Arrays across any distance for protection against disasters and datacentre wide failures."
Violin also states "With the ability to mirror between any pair of storage arrays, Maestro gives you full flexibility to use the storage array of your choice."
What Violin is saying with this box and its Maestro software suite, existing FC-connected disk drive array users can take advantage of all-flash arrays with a relatively painless data migration effort concurrently with SAN array data read access acceleration. It seems unlikely that mainstream SAN disk array vendors will offer the same migration capability with their own all-flash array initiatives.
The Force 2510 appliance is available now. There is no word on pricing. Get a Force 2510 datasheet here (pdf).®


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WWF first started field work in Greece in 1969, before an official office was set up, rehabilitating the Kaisariani forest on Ymittos.
The main office is located in Athens. However, it also has a presence in the Forest of Dadia, Lake Kerkini, Prespa Lakes, the area of North Pindos and the island of Zakynthos (Zante).The organization has a permanent staff of around 40 and hundreds of enthusiastic and valuable volunteers.
Founded: 01 January 1995


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Large group orders can take longer to paint, sometimes up to two weeks.
If you have a specific need-by date for an order, sooner than 2 weeks away, please contact us so we can ensure delivery.
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LAUREL HILL � What does it take to produce a Living Nativity program?
LAUREL HILL � What does it take to produce a Living Nativity program?
For Mary and Joseph, in the Bible, it was an arduous donkey ride over stony desert paths. For the folks at the Laurel Hill and Crestview Presbyterian churches, the logistics involve dozens of people, animals, props and equipment to assure the annual event runs smoothly.
The annual Living Nativity in Laurel Hill is 6-8 p.m. Dec. 8 at Laurel Hill Presbyterian Church, 8115 Fourth St. Parking is north of the church at the Laurel Hill School track. Admission is free, groups are welcome, and refreshments and fellowship will be provided. Call 682-2835 for information.
During the weeks leading up to Saturday�s Living Nativity, volunteers from both churches and their pastor, the Rev. Mark Broadhead, have been baking cookies, making cheeseballs, digging fire pits, changing the date on last year�s roadside signs, and making checklists and checking them twice. Over the summer, an electrician was summoned to rewire external electrical outlets to power decorative lights, floodlights and music sources during the event.
The Living Nativity takes a minimum of 12 actors, costumes, props, nearly three dozen behind-the-scenes volunteers, 450 luminaries, wood for six bonfires, a dozen or more bales of hay, one herd of goats, and a donkey named Patches.
Add in hundreds of miniature lights, a spotlight representing the Star of Bethlehem, and yards and yards of extension cords, including one heavy-duty line provided by Laurel Hill Mayor Joan Smith, who lives next door to the church.
Producing the annual event, which the church took over from the Presbytery of Florida�s Dogwood Acres camp outside Vernon, requires hundreds of hours of labor, Broadhead said. The churches follow a checklist and preparation schedule prepared from previous years� experiences.
�I think we�re getting better at it,� he said. �Now we just pray for good weather, but I�m only in customer relations. I�m not in management.�
Contact News Bulletin Staff Writer Brian Hughes at 850-682-6524 or email@example.com. Follow him on Twitter @cnbBrian.


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Will Russian President Vladimir Putin have second thoughts about the encouragement he has given separatists in eastern Ukraine if it turns out, as seems likely, that they shot down a Malaysian passenger plane Thursday with 298 people on board?
Perhaps not, since Putin appears almost immune to embarrassment and has himself authorized brutal military operations over the years with a high quotient of "collateral damage" in the form of lost innocent life.
The pro-Russian separatists have denied that they had anything to do with the tragedy, but then of course they would: It's a public relations disaster for them. Who else would be deploying anti-aircraft rockets in the area — reportedly a Buk anti-aircraft missile system — without the necessary expertise to hit the targets they had in mind?
If the separatists really are to blame, the rest of the world at least will have no excuse for underestimating their reckless disregard for human life, or for refusing to condemn Russian support of the destructive insurrection.
And civilian airlines, following the lead of British Airways and other carriers, should resolve to avoid that airspace.


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Consensus Report
Letter to Virginia Marine Resources Commission from the Committee on Non-Native Oysters in the Chesapeake Bay (2003)Ocean Studies Board
Each report is produced by a committee of experts selected by the Academy to address a particular statement of task and is subject to a rigorous, independent peer review; while the reports represent views of the committee, they also are endorsed by the Academy. Learn more on our expert consensus reports.
The Virginia Seafood Council has introduced a proposal to establish triploid C. ariakensis (nonnative oysters) into the Chesapeake Bay. Although triploid oysters are generally sterile, hence reducing the likelihood that these oysters will spawn, a small percentage (0.09 percent) will be diploid, or may revert to the diploid condition. The National Academies' committee reviewed the proposal and was concerned that it did not contain sufficient safeguards to reduce the risk of introducing a reproductive population of nonnative oysters into the waters of Virginia and neighboring states. This letter identifies several specific risks and concerns and recommends that the Virginia Marine Resources Commission amend the Virginia Seafood Council proposal to include additional safeguards.


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You'll blossom into pleasure with this velvety-sleek silicone twice-as-nice Japanese-made vibrator, featuring a bouquet of features with which to explore erotic sensation.
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For me, those downsides weren't enough to lessen the appeal, but it's worth noting that some of the perks it claims are not necessarily all they are cracked up to be. Still, though, it is worth it!
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1. Re: I7 Sandy Bridge Recall
- Intel® Core™ i7-2600 processor - Dell - Studio XPS
Features an 8MB cache and 3.4GHz processor speed.
- Features 8-way processing for ultimate smart performance. Intel® Turbo Boost Technology automatically speeds up your processor when your PC needs extra performance.ATI Radeon HD 5770 graphics ETC
- Intel® Core™ i7-2600 processor - Dell - Studio XPS
2. Re: I7 Sandy Bridge Recall
Hi...One site called ZDnet has a little bit more information regarding the chipsets like the core i7 mobile extreme,core i7 mobile,core i5 mobile,core i7 vPro and the core i5 vPro...They also say OEM systems carrying these products...On HotHardware,there is an article by Marco Chiapetto regarding this call back also and it says pretty much the same,but below that article in a forum there is mention a one person asking it their Asrock mainboard is affected and Marco's reply was pretty much yes or that it is also affected...That is all I can help you with,but all or most other sites mention OEM systems...
3. Re: I7 Sandy Bridge RecallDoc_SilverCreek Jan 31, 2011 10:19 PM (in response to cowboy0101)
Couger Point is the chipset, Sandy Bridge is the processor.
No problems with the processors, just the new H67/P67 chipset.
It is really a very minor issue for most applications, but Intel is going beyond doing the right think and making sure the ODM's can fix it.
This is the best write up I have seen on it.
4. Re: I7 Sandy Bridge Recallparsec Jan 31, 2011 11:20 PM (in response to Doc_SilverCreek)
Here is another article which seems to be factual as well:
5. Re: I7 Sandy Bridge Recall
Hi once again to all those will read my posts again...Yes it is true what you say,not the Sandy Bridge processor with LGA 1155 pinset number,but only with the Cougar Chipsets for the mainboards with LGA 1155 pinset number...We have to under stand is which one's are affected since they mention the manufacture date of the 9th,January,2011 and onwards have the affected chipsets...Also does it affect Intels OEM systems only or is it going to affect all mainboards with the cougar chipset...Also it is only affecting Sata 2 (3GB/s) ports and not the Sata 3 (6GB/s) ports...I forgot the exact percentage,but I think that it is either 5% or 20% of the affected chipsets...I read sites like ZDnet,HotHardware,PCworld,Bloombergs and others,but can not remember the site that had the sata 2 affected only ports write up...
6. Re: I7 Sandy Bridge Recall
Hi once again...It is Bloomberg's site that says 5% of the cougar point chipsets are affected...After doing some stress tests they found the fault...You will not find the part about Sata 2 being affected only and not the Sata 3,since they only mention the sata chipset issue... Also some other site that is too hard for me to find again had the up to 20% of chips affected out of the Cougar Point chipset that was shipped from the 9th,January,2011 and not manufactured on that date like I wrote up earlier,a mistake I wrote up on previous post...I also can not find write up which says that Sata 3 is O.K.,I will return after a while for a further search and I will this make bookmarks or add to windows explorer favourites list...
7. Re: I7 Sandy Bridge Recall
Hi once again...After searching for a while longer anantechs write up seems to be the best so far with the Sata 2 port issue stated clearly...The other write up that I seen before I can not find at all,so it is hidden deep down somewhere I do not know...Anyway they all mention the chipsets,but anantech goes that little bit further like the other site that I can not remember...To me it seems that I and others that bought the couger point chipset P67 & H67 mainboards will have to get them replaced if you want to use the sata 2 ports...I have not put my computer together yet,so I will try to return the Asus P8P67 Deluxe mainboard rather then putting it together and waiting for a fix or to have to return it for repair...I would advise people to try to return before they put their computer together...If you do try to keep it and only use the Sata 3 ports,you will lose the use of the sata 2 ports and they will become a waste...Remember the Core i7 and Core i5 processors are all good and nothing wrong with them at all...
8. Re: I7 Sandy Bridge Recall
Hi once again...I forgot to mention that if you have not put your computer together yet,try returning the mainboard/motherboard to the PC shop,dealer or what ever for a refund rather then wait for them to get in contact with you to send your mainboard back to get fixed or for them to advise you about using the Sata 3 ports instead...In the case that you are lucky enough to get a refund,this will solve your problem and you can keep the processor and other parts for when you think it will be safe enough to buy again and put a LGA 1155 based computer together...Beware though I am thinking of waiting longer so I can get a totally new mainboard rather then a returned for use as new fix up...
9. Re: I7 Sandy Bridge Recallparsec Feb 1, 2011 12:05 PM (in response to George )
George, although Intel is admitting there are potential problems with the H67 and P67 chipsets, it seems that you are saying that they are now or will soon be completely worthless. That is not what Intel is saying. They are saying that over time (years) and with many or all of the SATA 2 ports in use, a small percentage of these chips SATA 2 ports might fail. Intel discovered this while stress testing 'boards with these chips, in "hot boxes" at higher temperatures than most users will have in their PCs. We shouldn't be rushing into "the sky is falling" mode.
BTW, thumbs up to Intel for their action here, considering the cost and grief this "recall" will cause them. Imagine all the mother boards that I doubt can be simply fixed, replacing chips of that kind that, once soldered to the 'boards, are there rather permanently, since any removal and replacement is difficult and labor intensive with LBGA type chips, AFAIK. You cannot just attack it with a solder iron, as these chips were not soldered in place by hand in the first place. Even if they could be removed, attaching a new one to an otherwise fully assembled 'board will not be easy, if even possible. Above all this, the labor and cost of replacing these chips, including the retesting of the 'boards, is likely more than it is worth to do it.
According to the AnandTech article, replacement boards will not be available until March. So you can't even get a "fixed" 'board yet. It remains to be seen what the replacement procedure will be. Rushing to return these mother boards will serve no purpose, beyond having your new Sandy Bridge CPU in it's box on a shelf. There is no mention of damage to 'drives connected to these chipsets, but of course if your data is irreplaceable and the PCs data storage function critical, there is some potential danger there if the port fails during a write operations. Apparently, Intel discovered this problem themselves, not from reports from owners or manufactures, which means problems "in the field" are not what triggered this.
If I owned one of the affected mother boards, I would make sure my PCs case is well ventilated, use only a fraction of the SATA 2 ports, use the SATA 3 ports, and wait and see what the procedure for replacements will be. Those steps are insurance against failure and will likely help in keeping any problem from occurring, which seems unlikely given the information we now have.
10. Re: I7 Sandy Bridge Recallrednekcowboy Feb 1, 2011 12:34 PM (in response to parsec)
Unfortunately, for HTPC users like myself who bought a board specifically for the number of sata ports on it, the answer you provide of using a limited number of ports is not a viable option.
I have 6 sata devices and need them all running for my movie collection. While I do realize the risk is minimal, I need a viable solution now, not a month from now.
I also object to you giving a "thumbs up" to intel for coming forward here. Trust me, any major corporation would not do this out of sheer good will. They have anticipated many issues that will come as a result of these deffective chips and have weighed that against the losses they will receive by issuing a recall and have decided it is cheaper to do the recall. They didn't do it out of some "moral obligation" as you suggest.
This situation is a result of not thoroughly testing their product prior to sending it out to the masses. It is a situation created by them and is being resolved by them, however it should have never occurred in the first place, hence the recall.
Let's all be honest about the current situation here.
11. Re: I7 Sandy Bridge Recall
Is parsec an intel plant? He certainly seems to be pooh poohing the issue. The system i just built three days ago has this 'defective' chipset and not only myself but many enhusiasts who chose 'Intel' are not feeling all warm and fuzxy about this.
IMHO intel needs to advance replace these boards once the workaround has been implemented.
12. Re: I7 Sandy Bridge RecallSonny Feb 1, 2011 4:07 PM (in response to cowboy0101)
For the latest information, go to: http://blogs.intel.com/technology/
13. Re: I7 Sandy Bridge Recall
Hopefully Intel comes up with the solution to send out advanced replacement boards when they are ready. Right now they are referring you to an automated support article on troubleshooting issues that don't petain to the chipset problem.
Of course the other option right now is to direct you to open a chat session which is always busy or asks you non-sensical questions and then suggets you contact the supplier where you bought the board. Well, Intel, the board and processor go hand and hand and neither can be used without the other !!!
Having put the system together already, I don't think the retailer will also accept a perfectly fine but otherwise useless processor (can't use it with anything else) as they would now lose out on a motherboard and prcoessor RMA.
So, even If I get a refund on the board then i'm stuck looking at a processor that i can do sh** with and have no computer for my business in the meantime.
14. Re: I7 Sandy Bridge Recallparsec Feb 1, 2011 11:02 PM (in response to technolad )
Sorry to disappoint you, but I'm not an Intel plant (dang, I should be getting paid for this!)
I have criticized Intel in this forum many times, my Intel DG45ID mother board with it's flaky BIOS and associated weird functioning being the main cause of that. Actually, there are several Intel employees that post in this forum that are not identified as such, or are moderators, but I am not one of them. As with other manufacture's forums I have experience with, the standard policy regarding discussing or defending their products problems seems to be this; Say nothing whatsoever.
Unfortunately, I cannot take credit for the suggestion to use the two SATA 3 ports, that was done in one or both of the AnandTech articles on this topic, one of which is linked at the top of this thread. Of course that does not solve this problem, and is just a simple, partial workaround, that will not satisfy all users as redneckcowboy points out.
He also wrote the following:
"I also object to you giving a "thumbs up" to intel for coming forward here. ... They didn't do it out of some "moral obligation" as you suggest."
Which apparently was inspired by this:
BTW, thumbs up to Intel for their action here, considering the cost and grief this "recall" will cause them.
Talk about reading between the lines, where did I ever suggest that? My point is that when these ports fail, how would the user know it was the chipset that failed? They would just think, "... bad mother board, RMA time...", the end. Can anyone tell me who could diagnose or identify the exact problem besides "bad H67 chip" other than Intel? Even if we could determine the cause is the H67 chip. Not to mention prove that the mother board manufacture did not do something wrong in their use of the chip? In short, this would be an easy flaw to hide, IMO. But they admitted it, on their own, without being forced to do so, and are planning compensation to the customer. I felt that this earned them an, "Ok, good", not a "You !@#$%^&*!".
My comments are based entirely on the information in the AnandTech articles. So are the suggestions, I am simply paraphrasing statements from the articles. Have you read them? If not, please do so, if only to possibly alleviate some of your concern over this problem. Given some of the comments by my detractors, it seems the articles were not read.
I never said it didn't exist. I never said it doesn't matter. All I'm saying is given the information we have right now, it does not sound like a huge and immediate disaster that will never be fixed, we know how to keep your affected PC running if you choose to do so, and we already know that those affected will be compensated.
I see plenty of honesty in this, all this information from day one, and this is day two. I could quote Intel's statement in the AnandTech article regarding the chances of this occurring in the affected PCs, but I imagine that will be dismissed as a lie. You'll need to forgive me for not immediatetly jumping on the anger and hate bandwagon. Burn the witch!!


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DENVER (AP) Pinch-hitter Charlie Culberson felt good about his swing and then felt even better an instant later when he saw the ball he hit sail over the center field fence.
Culberson hit a game-winning two-run homer in the ninth inning off Kyle Farnsworth, and the Colorado Rockies, down by six runs early, rallied again to beat the New York Mets 11-10 in a wild affair on Saturday night.
It was his first homer of the season.
''I don't hit many home runs, but for some reason right there, I hit it and I just knew it had to go out,'' Culberson said. ''More to the point, like it had better go out.
''Hitting a walkoff, I really can't describe it. That's definitely the best feeling I've ever had in baseball, so far.''
The Mets overcame Colorado's eight-run fifth inning, that included Nolan Arenado's grand slam, and took a 10-9 lead on Juan Lagares' RBI single in the ninth off LaTroy Hawkins (1-0).
But Troy Tulowitzki, who recorded his 1,000th career hit earlier, singled off Farnsworth (0-2) to start the bottom of the ninth. He advanced to second on a deep flyout by Arenado, and Culberson followed with the winning drive off a 1-2 pitch from Farnsworth.
The crowd erupted as he rounded the bases. As he neared the plate, he tossed his helmet and jumped onto home plate as he was mobbed by his teammates.
''He threw a first-pitch fastball about 95 mph, but I saw it pretty good and I knew he was going to go after me and try to get me out,'' Culberson said. ''He just gave me a good pitch to hit and I barreled it up.''
Farnsworth said he didn't quite get the location he wanted.
''Fastball away. It hit the middle, I guess,'' Farnsworth said. ''He got a good swing on it. It's always difficult. We just have to keep on battling. Guys played well, and we came out on the wrong end of it.''
It was a sudden finish to a game in which the teams combined for 30 hits, including Arenado's slam that extended his major league-best hitting streak to 23 games.
Tulowitzki notched his 1,000th hit in the seventh when he singled up the middle off reliever Daisuke Matsuzaka.
''I think the No. 1 thing on my 1,000th hit is I'll remember this game and how we won it,'' Tulowitzki said. ''That makes it that much more special.''
The ninth-year pro became the fifth Rockies player with 1,000 hits and the 78th active player to reach the milestone. He scored from third on Jordan Pacheco's sacrifice fly to give Colorado a 9-8 lead, but the Mets tied it again in the eighth on Chris Young's RBI single.
Staked to an early 6-0 lead, Mets starter Jenrry Mejia had blanked the Rockies through the first four innings and seemed headed toward the solid pitching outing New York needed. Instead, he became the third straight Mets starter to fail to get out of the fifth after the rotation began the season with 26 straight starts of at least five innings.
The turnaround was triggered by Ryan Wheeler's first home run of the season leading off the fifth. The Rockies sent 11 men to the plate in the inning.
In one stunning five-pitch stretch, Mejia gave up RBI singles to Charlie Blackmon, Drew Stubbs and Carlos Gonzalez as the Rockies made it 6-4.
Mejia then hit Tulowitzki in his upper left arm with a pitch to load the bases, and Arenado drove the next pitch into the left field bleachers for his second career slam and the first by a Rockies player this season. Arenado also tied Dante Bichette for the second longest hitting streak in Rockies history.
Matsuzaka then relieved Mejia, who gave up eight runs and nine hits in 4 1-3 innings.
The Mets, who built a 6-0 lead off Rockies starter Franklin Morales, fought back in the sixth to tie it at 8, getting a run-scoring double from Young and an RBI single from Curtis Granderson.
Daniel Murphy got the Mets going with a one-out triple in the first and scored when David Wright followed with a double. Anthony Recker and Lucas Duda added RBI singles.
New York added to its lead when Wright singled to start the third, stole second and took third on a groundout. He scored on Granderson's single, and Granderson came in on a double by Anthony Recker, who scored on third baseman Arenado's throwing error.
NOTES: Bichette had his 23-game hitting streak in 1995. ... RHP Chad Bettis was optioned to Triple A Colorado Springs, and the Rockies recalled catcher Michael McKenry. ... RHP Jhoulys Chacin, who began the season on the disabled list because of a right shoulder strain, is slated to make his season debut Sunday for the Rockies against Mets RHP Dillon Gee (2-1). ... Wright, who had three hits, has a career batting average of .391 at Coors Field, his highest at any ballpark.


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According to The London Evening Standard, approximately 1 in 10 women who undergo a caesarean section will suffer from a related infection. Findings from the British Journal of Obstetrics and Gynaecology revealed that infection was more common in women who were either overweight (1.6 times more likely), or obese (between 2.4 and 3.7 times more likely) than those women of a healthy weight.
Plus: Obese Dad Denied Custody Over Weight
Out of the women who suffered from infection, the majority of infections, 88% in fact, were minor, though 25 of the 4,107 women in the study developed serious infections in the lining of their wombs. And two women from the same study, conducted by the Health Production Agency (HPA), were diagnosed with reproductive tract infections. Additionally, research revealed that women under the age of 20 were at a greater risk for infection, as compared to those between the ages of 25 and 30, though researchers at the HPA are unsure of the reasons behind this finding.
Plus: Does a C-Section Make your Baby Fat?
Dr. Elizabeth Sheridan, head of healthcare associated infections at the HPA, worries about these statistics, especially in light of the fact that one in four births today are done via caesarean section. Sheridan hopes that all women having c-sections for non-medical reasons will be aware of all the risks that are associated with this procedure, especially the risk of infection as a new mother.
Plus: Study - U.S. C-Section Rate Reaches All-Time High
Would you consider having an elective c-section? Did you suffer any postnatal infections after giving birth? Leave a comment.


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- Doctors
- California
- Orange
- Oncologists / Hematologists
- Dr. David A. Margileth
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Ratings for Dr. David A. Margileth
I first met Dr. Margetlith in February of 1993. I had my firt breast cancer and he was my oncologist. Wonderful man and tops in his field as far as I was concerned. Unfortunately, my breast cancer came on the other side and again Dr. Margelith took care of me. I can't say enough about his care and concern for his patients. I even moved with him to the then new Pavillion. I've sinced moved out of the area but I had another issue and went straight to Dr. Margelith for a second opinion. His opinion turned out to be right on the money and I was treated at UCSD in 2007 for ovarian cancer where I've run into another fabulos doctor, Michael Mchale. Whereever I am in Southern California I'm comforted by the fact that I can go to either one and feel completely confident I'll be taken care of. Thank you for the opportunity of letting me say "Thank You" to him.
I have been seeing dr Margileth for over 20 years now and he is a kind,caring and knowledgeable dr
I have been with Dr. Margileth for almost 6 yrs as his patient. He is extremely caring and thorough. He is very knowledgeable about the latest cancer protocols.I am one of those patients that makes sure the doctor knows I am in charge of my treatment. They well understand that and support me.Another person mentioned that he seemed "tired" Well 4:30 is the last patient timeslot, she needs to understand that he has a mentally and emotionally taxing job, and that being tired is a result of being invested. He is a VERY caring man and that's hard for someone in the position of watching your patients sometimes die. I have stage IV now, it hit him pretty hard because I am very young. I trust him completely but I am also the one who makes all of the decisions regarding my health. I suggest people take control of their disease. Tap the resources of this intelligent man but make smart decisions, ie; educate yourself.
I went to see Dr. Margelith for a consultation about my recurrence. I will say he gave me enough time but he sure seemed awful tired. I felt like I was keeping him awake. But in his defense it was the end of the day...I was scheduled at 4:30 PM. He answered my questions but I really went there for his recommendations about my chemo options. He just read the recommendations I already had from two other oncologist and agreed with them. No new input...nothing. He comes across very dry and impersonal. Not real friendly at all. (That is probably just how he is?) I wasn't impressed with the physical exam at all. It was too quick and he hardly felt for anything. When you have a very aggressive stage III cancer you WANT a GOOD exam. He barely touched me. I was hoping I was going to like him so I would have a new oncologist as I'm not happy with mine. But we weren't a good match I suppose. He was sitting down leaning his chin on his hand the entire time like he was ready to go to sleep.:(
dr margileth has been my dr for 18 years he is the kindest most knowledgeable dr i have ever been to since I was diagnosed with cancer 20 years ago. He takes plenty of time with you and is very caring. I would highly recommend him.
I was treated for breast cancer in 2008 by Dr. Margileth. He is a wonderful doctor - takes his time with you and explains everything in detail. I was never kept waiting. His staff is absolutely awesome. Any time I had a problem, they were right on top of it. A phone call was alway returned immediately. Having cancer was a scary thing, but I felt that I was in the best of hands. The new cancer center at St. Joseph's in Orange is top notch.
Dr. David A. Margileth's Credentials
Facility Affiliations
Accepting New Patients
- Baylor College Of Medicine (Grad. 1971)
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John Dewey isn't furloughing any of his 31 employees at Dewey Electronics Corp., and he won't be closing the doors of the Oakland-based defense contracting business if the federal government shuts down at midnight, as expected.
But that's not to say he's taking it lightly.
"I don't think the U.S. government is going away," said Dewey, the company's CEO. "But they sure are working hard to become an inconsistent business partner."
Dewey's firm, which manufacturers power generators and systems for the military, is among scores of New Jersey businesses whose contracts may be harmed by the looming government shutdown. That's the expectation if Democrats and Republicans in Congress cannot agree on a spending bill today, a crisis that would be the latest political standoff in recent years to shake the confidence of businesses and the public.
Henry Savelli, a Trenton-based contracting consultant, said the shutdown could touch businesses across a range of industries, from construction and transportation to defense and Hurricane Sandy relief work. He pointed especially to the U.S. General Services Administration, which handles billions of dollars in procurement annually is support of other federal agencies, and can take four to six months to process bids, he said.
"Anything that's in the pipeline, those businesses in New Jersey that are waiting for a contract from the federal government — that will be delayed," said Savelli, owner of Henry Savelli & Associates.
Patrick Guidotti, of Robbinsville-based PJG Consulting, said the shutdown looms especially large for defense contractors and firms of all types that supply services to installations such as the Joint Base McGuire-Dix Lakehurst.
"They're going to be impacted," Guidotti said. "They're working off contracts and there isn't going to be any money to pay them … I don't see how they're going to get around that, because they're only going to be providing money for essentials."
The federal government has not shut down since 1995, though fiscal brinkmanship on Capitol Hill has become increasingly common in recent years. For Dewey, episodes like a near-shutdown in 2011 and the across-the-board spending cuts known as sequestration have created a pattern of uncertainty.
"There have been these white-knuckle conflicts around every budgeting cycle, so it's been really hard to do business," Dewey said. "Every time we kind of get a program going or a research and development effort going, these things crop up and it kills progress."
To compensate, Dewey has moved to do more business directly with foreign militaries, he said. It's become a better option when the government at home and other businesses are reluctant to start the research and development projects that require Dewey's services.
"Everyone is just trying to keep their doors open in a really chaotic marketplace," he said.


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Crucial Ballistix BL2KIT25664FN1608 Memory Review
The Crucial Ballistix line of RAM has been widely known and favored by performance enthusiasts for quite some time now. The kit being reviewed is a 4GB kit rated at DDR3-1600 frequency with 8-8-8-24 timings at 1.65v. This kit also contains an Intel XMP profile for easily setting the rated frequency of 1600 MHz from within the BIOS.
This Ballistix RAM brings something new to the memory table, with the addition of an integrated thermal sensor for real time thermal monitoring. All that is needed is a small download of the M.O.D. (Memory Overview Display) utility from the Crucial Website to be able to monitor the thermal performance of your RAM in a graph and also a table format (when enabled) in real time.
We will check out the thermal monitoring along with the performance of the BL2KIT25664FN1608 kit to access what this kit has to offer at both stock and overclocked profiles.
Closer Look:
The packaging is just your standard plastic sealed blister pack. The accompanying cardboard face includes the statements "High-Performance Memory", "Premium Memory" and "Limited Lifetime Warranty". The back states, "Crucial Ballistix high-performance memory is engineered specifically for gaming enthusiasts and system modders. Featuring advanced speed grades, low latencies, and sleek integrated heat spreaders". In the center is a very brief illustrated memory installation tutorial.
This memory, BL2KIT25664FN1608, is rated to run at 1600 MHz with a timing of 8-8-8-24 @ 1.65v, so, not bad for today's DDR3 memory offerings. The memory has a high profile aluminum heat spreader that should be capable of removing excess heat to keep this RAM running cool, and now that it also includes an integrated thermal sensor it will be very easy to find out.
Let's take a look at how this memory performs, and whether it lives up to the Ballistix name.


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A recent news item published by HealthScout offered this advice for people bored with conventional exercise: "If you want to buy an exercise machine, go to the local dog pound and adopt a dog." Since my apartment is a veritable Noah's Ark of adopted animals, I feel guilty knocking an article that encourages people to rescue dogs from shelters. But I've got to tell you: I own a dog, and a dog can't take the place of exercise equipment.
Consider this study from the Medical Journal of Australia, released days after the HealthScout piece: After randomly surveying 894 New South Wales adults, researchers discovered that people who owned dogs weren't particularly active compared to the rest of the population. In fact, of the 411 dog owners who participated in the survey, less than half performed the recommended 150 minutes of physical activity per week. The researchers also learned that only 15 to 20 percent of dog owners walked their dogs for two hours a week. And 59 percent didn't walk their dogs at all!
I'm not sure how these numbers stack up to U.S. dog owners. However, given our country's growing obesity problem, I assume they're pretty much the same.
I could be wrong. Americans may walk their dogs more often than Aussies do. Even so, I'm still not convinced that dog walking qualifies as meaningful exercise.
I'm speaking from experience. I take my dog out twice a day, my wife takes him out once. Altogether, I probably walk him for at least three hours a week.
The trouble is, the word "walk" is misleading. My dog and I are not exactly walking the whole time we are outside. He pulls, strolls, chases, sniffs, stops, stares, digs, marks territory. I'm just along for the ride. Sure, I spend time walking. But I also spend time standing still while he plans his next move. I also do my best to look cool as I clean up any mess he leaves behind. Believe me, walking a dog can be an exercise in humiliation, but it's not exercise.
As a test, I once wore my heart rate monitor while walking the dog. The monitor beeps whenever I fall out of my zone. In this case, it never stopped beeping. I never even got into my zone. I tried moving faster, swinging my arms, anything to make the activity more strenuous. Nothing worked. All I succeeded in doing was confusing my dog. As I picked up the pace and flailed my limbs, he gave me a look that said, "Dude, what's your problem?"
I suppose I could have tried a steady jog. Dogs will usually follow an owner's lead. Run, and dogs will run with you. The drawback is they won't stop until you do. As a result, they may push themselves to the point of exhaustion. That's why clubs offering dog-walking outings usually set parameters to keep members and mutts safe. After all, walking a dog isn't about racing him. It's about giving him a chance to do all the things you don't want him to do in your home. Know what I mean?
To be fair, some breeds love activity. These dogs make perfect pets for people who want to exercise with an animal. However, the opposite is also true: Some dogs hate to move.
I know a guy who has two basset hounds. If he tries to walk them more than a block, they simply stop and refuse to go on. Have you ever tried to coerce a stubborn basset hound into walking? It's not pretty.
The point is this: Dogs are not substitutes for exercise equipment. They're not substitutes for clubs. So when faced with prospects who are choosing between dog ownership and a club membership, tell them this: If you're looking for companionship, rescue a pooch from the local pound. But if you're looking to improve your health, join a club. Just make sure to leave your dog plenty of food, water and toys when you go to the gym.
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Situated between Digbeth High Street and Bradford Street, Deritend Bridge is a mixed use development comprising offices, shops, hotel and residential accommodation. Outline Planning Approval has been granted for a total area of 31, 000 sqm.
The development site is bisected by the River Rea which allows for a public space in the heart of the site and a riverside walkway to generate a high level of pedestrian access into and through the development. Two basement car parks serve the multi-storey blocks over.
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It's day three at SXSW Interactive and people are buzzing about the famous names, the happening parties, and yesterday's keynote speech on Google Buzz's privacy blunders by Danah Boyd. A large majority are also busy tweeting about Twitter and Foursquare issues -- highlighting just how important these services have become to the interactive lifestyle.
Crimson Hexagon looked at a representative sample of tweets over the past three days and found that a chunk of the backchannel conversation is focused around frustration with Twitter issues and Foursquare hiccups. Of the 4,500 tweets analyzed, 27% are discussing the startups' challenges trying to keep the lights on.
Relatively speaking both Twitter and Foursquare are handling the excessive load quite well. Sure there have been blips on the radar, but those blips have been amplified by the nature of the respective social media services.
Of course Foursquare can wear the exclamatory tweets over service outages as a badge of honor. The location-sharing service is now a legitimate contender for mainstream attention and the tweets demonstrate just how much users have integrated checkins into their digital lives. Demonstrating such, Foursquare achieved a major milestone yesterday -- 347,000 checkins in one day.
Another interesting finding is that for nearly every tweet expressing love for the event, there's one mentioning how bloated SXSW feels this year. The show is noticeably bigger -- up 4,000 attendees from the previous year -- and it's hard not to feel like panels and parties are bursting at the seams.
Equal percentages (13%) are using Twitter for name dropping and bemoaning the cost of the show. Some of those venting about the price of food and the pretty penny they paid for their hotel room are also going so far as to say that SXSW is not worth the expense.
With two more days remaining, it should be interesting to see how conversations evolve and whether or not the value of SXSW becomes apparent to the current naysayers.


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Hi All,
I want to track the number of the clicks, on the links.I coded to track it , which works in the preview.I am able to track the links when clicks in the preview.But If I click on the mail the java script is not executed.
I have used Onclick="function_name()".
Any suggestion could be great to proceed .


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Simon The Sorceror
During this game you will have to do quite a bit of running around. Not all of the places you will find are shown on the map that Simon carries around. You will be asked to do several things in various places and need to return there. In order to avoid too much "looking for places", I suggest that you draw a map of your own. When arriving in Fleur Deli you will automatically read a note from Calypso. Read it carefully. Open the drawer in Calypso's desk and take the scissors. There is a magnet on the fridge. Take it (you cannot open the fridge!) and go outside. Behind the cottage you will find compost which will be used later. Leave the scene to the right. At the Blacksmith's take the rope and the clapper. This guy doesn't have time to talk since he is hard working throughout the entire game. Walk to the right and talk to the dodgy geezer. He is of no use to you right now. Turn left and take the ladder leaning against the wall. Enter the building (the entrance is in the middle of the picture). Pick up the cold remedy and the specimen jar. Leave the building and you can follow the path to the left. There is a funny house with a chocolate truffel door. However, you cannot do anything here at the moment. Walk back to the dodgy geezer and turn to the right. Enter the shop and talk to the shopkeeper(s). If you go right you will find a place called the Drunken Druid. Inside you can pick up the matches from the fruit machine and talk to the Barman. Then enter the next room. These guys are really hard to understand but you should definitely talk to them until they tell you about the staff they want. Go back to the bar. Use your scissors on the dwarf (this poor soul will be surprised...). Exit the bar and enter the forest outside the village. Walk to the witch's house and move the handle on the well. Pick up the bucket of water. Then open the door and enter the house. Look around a bit. When you try to pick up the broom, the witch will appear and throw you out. Wander around in the forest until you find a tree stump. Talking to the woodworm reveals that they are in desperate need for some wood, preferably mahogany. Now find the Barbarian and remove the thorn from his foot. He will give you a pipe in return. At the Owl Tree you should pick up the feather. Talk to the owl a couple of times and listen carefully. A visit to Dr. Von Jones would be good now. Although he is working in the hole, you can talk to him and find out what he is looking for. Since Simon is a very helpful person, he again promises to help. At the centre of the forest, pick up the rock with the writing on it. Wear the beard and enter the Dwarf Mine (you know the password as it's written on the rock!). The guard will not let you pass at this point. However, you can use the stairs on the right and find two completely drunken dwarves. Use the feather on the one lying on the floor, take the key and leave the mine. Near to the Dwarf Mine is a building with two heavy doors. Pick up the piece of paper lying under a stone and give it to the shopkeeper(s) in the village. Also near the Dwarf Mine you can find the woodcutter. Unfortunately, he has a real problem, too. If you promise to help him, he will assist you by giving you a metal detector (Going to the right from here will bring you to a gorge. You can see somebody fishing but you cannot reach him from here.) The third path leaving the Dwarf Mine area leads to a funny swampling who is all alone on his birthday. Do him a favor and eat some of his homemade stew. If you cannot take anymore of this delicate food, put it in your specimen jar. Go to the Troll Bridge now. The troll is very interested in your pipe. Give it to him and watch. In the second part of the forest, on the other side of the bridge, you will walk into a boy who has a problem with his beans. Use the bucket of water. This ungrateful kid will leave and you have some beans for your inventory. Go on to the Gorge and look down. To visit the fisher, climb down the vines on the left. Talk to this funny guy. To help him with his dinner, provide him with some fine concentrated "Stew de Swamp" in your jar. He will give you his fishing rod so that you can catch a very special ring with it. Go back to the crossing and walk to the castle. Use the clapper with the bell and "Rapunzel's" hair will fall down. Climb into the window and talk to the girl. When you kiss her, you can take a repulser back with you... Return to Calypso's cottage and plant the beans in the compost. Take the melon. Now go to the chocolate truffel house and let the repulser eat the door. Inside, pick up the hat and smokebox and walk to the beehive. Use the smokebox on the beehive and pick up the wax. At the Drunken Druid you should ask the barman for a drink. While he is searching for some ingredient, use the wax on the barrel. You will receive tickets and vouchers for free beer. On your way out put the barrel in your inventory. Go to the Dwarf Mine and wear the beard. Offer the barrel to the guard. He will walk down to the barrel cellar with you. Go back to the desk dwarf and walk down the stairs on the left. Pick up the hook and talk to the dwarf in the middle. Use the key on the door and then give the tickets and vouchers to the dwarf in the treasury. He will give you a gem in return. Time to see whether or not the dodgy geezer is of any use in this game. Offer him the gem (get 20 gold coins for it). With this money you can buy the hammer and the white spirit in the shop. Outside there is a box you should open. You will be taken to the gobblins. There is a rat bone on the floor as well as your spell book. In the spell book you will find a piece of paper with scribblings on it. Use the paper with the door and the rat bone with its lock. The key will fall on the paper so that you can open the door. Pick up the metal bucket. You cannot pass the guard, however, walk downstairs. Pick up the mints and talk to the druid. Since he is a little superstitious, you should take off the ring while talking to him. Druids can change into animals when they see a full moon. So put the bucket on the druid's head and show him the glowing rod. He will change into a frog and leave you alone. To hide from the gobblin troops, walk into the iron maiden and close it. You can leave it when the troops disappear. The frog will then return and give you a hacksaw which you can use to get out of this room. Find Bard with his awful sousaphone. Use the melon on the instrument and take if for "repair". Visit the swampling's house again and move the box. Open the trap door and climb down the ladder. Use the hammer and nail with the loose plank. Pick up the frogsbane on skull island. Near the swampling's house is a cave leading into a snowy mountain area. Use the metal detector there and leave it where it gives you any signals. Walk on to the sleeping giant and play the sousaphone so that he provides you with a comfortable bridge. On the other side in the mountains, you will find a cave with a dragon. Since this poor guy has a terrible cold, offer him your cold remedy. Pick up his fire extinguisher and leave the cave. Above the cave entrance is a boulder. You can climb up there by throwing the hook on it. Tie the magnet to your rope and let it down into the hole. Watch your money and stop when you can't get any more of the dragon's gold. Continue walking in the snow until you find a path with climbing pins. Pick up the rock lying there. Walk on the icy edges leading to the right and go until you find a talking tree. Use the white spirit on it and it will tell you some magic words. Return to the blacksmith and ask him to get the fossil out of the rock. Find Dr. Von Jones and give the fossil to him. If you tell him that you left the metal detector where you found the fossil, he will dig there. Follow him and get the milrith out of the dirt. Take the milrith to the Blacksmith, so that he can make an axe out of it. Apparently, now is the time for Simon to fulfill some of his promises. Go to the woodcutter and give him the axe. He will leave happily. Enter his house and pick up the climbing pin. Use the fire extinguisher on the fireplace and move the hook. Enter the fireplace. You will find various types of woods, but unfortunately you are allergic to most of them. Pick up the mahogany and take it to the woodworm. They will love it so much that they get into it while it's still in your inventory. Go to the castle where you found "Miss Piggy". Climb up and ask the woodworm to do you a favor on the floorboards. Use the ladder to get down. You will end up in front of a tomb. Open it and talk to the mummy. You will have a wedge afterwards. Go down again and grab the loose end of the bandages. There you are: the staff! Return to the village and give the staff to the wizards. After some discussion and payment of a fee, they will make you a wizard yourself! Congratulations, you've made it through the first part of your quest! While you're in the village, visit the druid and offer him your frogsbane in return for a potion. You're all set for the witch now. Visit her and play the game with her. She won't be fair and change into the dragon once you have won the game and the broom. Change into a mouse and disappear through the mousehole in the wall. Continue your quest at the place where the climbing pins are. Use your climbing pin in the hole and cross the gorge. The snowman is very unfriendly and, therefore, requires appropriate punishment. Eat the mints and walk up to the Tower of Doom. Being a lucky guy, Simon can use the broom to get to the door. There is a little crack in the door. Drink the potion from the druid and walk through the crack. Your lovely dog will take care for you to reach a beautiful garden and will even provide you with a useful hair. Pick up the leaf and the pebble and walk into the bucket. You will find a match inside. Go on until you reach the water and get the lily leaf. Put the match in the lily leaf, use the small leaf on the match and ready is your boat. Sail to the seeds and pick up one. Sail back and use the stone with the seed to produce oil. ATTENTION: Before taking the next steps, you should try to sail across the puddle once, just to see what happens! Put the oil on the tap and use the hair on it to open it. Now, you can sail to the other side of the puddle. Go to the frog. He will nearly swallow you but he lets you out of his mouth again. Look into the water and catch the tadpole. You can talk to the frog now and he will jump away. Put the tadpole back into the water and eat a mushroom. You're back to normal size now. Pick up the branch and open the door. Enter the building and get the spear. You will escape in the garden. Enter the building again and use the branch with the monster-chest. Then take the shield. Now go downstairs. Get the chest on the right side and go back. Then move the lever. Put the chest on the block and move the lever twice. Take the candles from the block and use the spear to get the human skull. It falls onto the floor from where you should pick it up. Go upstairs into Sordid's room. Pick up the book and look at it. Take the wand from the desk, pick up the sock and the pouch. Use the sock with the pouch and use it with the mouse hole. You will catch a mouse. Go further up and talk to the demons. Take the chemicals and the book. Read the book, then use the chemicals with the shield and hang it on the hook. Walk back to Sordid's room and talk to the mirror. If you heard the real names of the demons you can return upstairs. Send the demons home. In return they will tell you something about the teleporter. Use it and ask to be taken to the fiery pits. Pick up the pebble and the sapling and talk to the attendant. He will give you some brochures. Look at them and use the elastic band with the sapling. Aim with your catapult at the fire bell. The attendant will disappear and you can take the souvenir matches and go into the pit. On your way to Sordid, pick up the floor wax. When you see Sordid, use the wand on him. Since the pits are not on fire, use the matches with the pit and throw the wand in it. Unfortunately, Sordid comes back to life and wants to kill you. A phonecall will save your life. When Sordid is near enough, use the floor wax on him.
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This week in Island history
100 years ago From the Newport Daily News, November 18, 1908
In spite of the lack of rain at planting time, which made the seeds slow to germinate, the turnip crop that is about harvested is one of the best ever raised on the island.
From the Newport Daily News, November 21, 1908
Barge Richard Jackson of New York is in with a cargo of 500 tons of coal for the Ferry Company.
The Fort Greble football team crossed the ferries to play at Fort Adams.
75 years ago From the Newport Daily News, November 16, 1933
(At the town council meeting) it was voted that the Phillips garage be placed on the list as a local garage to be patronized in town by the town's trucks and for supplies and repair work.
From the Newport Daily News, November 20, 1933
A petition containing more than 350 names favoring the building of the proposed bridge from Saunderstown to Jamestown has been received by the town council and placed on file.
50 years ago From the Newport Daily News, November 17, 1958
The Coast Guard at Boston today confirmed that it is weighing a plan to remove Brenton Reef Lightship for economy reasons.
Fire of undetermined origin Saturday destroyed an old stable owned by Eric Moberg, on the former estate of Webster K. Wetherill on Bay View drive. The fire department kept the blaze from spreading to nearby summer residences.
From the Newport Daily News, November 21, 1958
The historic Brenton's Reef Lightship will continue to shine, the Coast Guard said today in canceling plans to remove it from its station outside Newport harbor.
The Jamestown Elementary School lists 120 pupils on its roll for perfect attendance for the first term recently ended. (The names of teachers for grades K-8 and students with perfect attendance are listed.) From the Newport Daily News, November 22, 1958
Efforts to have a sign placed at the New London exit of the Connecticut Turnpike to direct motorists to Southern Rhode Island and the Jamestown bridge and ferry were continued at a meeting of the Jamestown Bridge Commission last night. … The manager and treasurer were directed to see that the Jamestown branch of the Industrial National Bank is used to as great an extent as possible.
Jamestown's new fire department museum, a Colonial structure to house the horse-drawn steam pumper the town used for years and other antique fire fighting equipment, was dedicated Thursday night. It is a memorial to all deceased members of the town fire department.
25 years ago From the Newport Daily News, November 22, 1983
A plan to relocate East Shore Road won support from island residents Monday night at a hearing on a connector road between the Jamestown and Newport Bridges. Three options for a connector road were unveiled Monday night to about 70 people at the second of four public workshops by the Jamestown Design Study Committee.
15 years ago From the Jamestown Press, November 18, 1993
Jamestown will soon acquire title to eight acres of federally-owned land at the corner of Eldred Avenue and East Shore Road for use as a municipal ball field, without having to spend a dime.
The Town Council Monday voted unanimously to terminate water deliveries by the National Guard immediately. Sitting as the Board of Water and Sewer Commissioners, the council also voted 5-0 to present the Guard unit a plaque for transporting about 8 million gallons of water from North Kingstown to the town's North Pond reservoir during the island's water crisis. The Guard began delivering water in mid-September.
10 years ago From the Jamestown Press, November 19, 1998
It may be chilly November, but it's still baseball season in Jamestown as "Damn Yankees" suits up and takes to the stage for its final innings this weekend.
At a school open forum Tuesday, parents grappled with tension-causing issues that they face while their children are adjusting to the new "standards" philosophy of learning at the Jamestown School. A source of contention, especially among junior high school parents, is the grading system that is still in the developmental stages.