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The importance of proteins in biology cannot be overstated. Proteins are valuable therapeutic compounds, research reagents and industrial catalysts. Using proteins designed with GeneGPS® optimization provides the highest levels of expression, saves you time and money, while getting you quickly to meaningful results.
Using proteins with the highest levels of expression saves you time and money, while getting you quickly to meaningful results.
ATUM Unlocks the Secret of Truly Optimized Gene Design
Breakthrough research by ATUM, funded by NSF, has identified the design principles by which codons are used to maximize protein expression. The surprising results were published in PLoS ONE.
ATUM has used the results of this research to create GeneGPS with its robust gene design algorithms. These new design algorithms routinely produce 10-100 times more protein than competing methods. ATUM can even test your gene for high expression.
Expression of Recombinant Proteins Depends on Codon Optimization Choice… Make the RIGHT Choice.
Expression of recombinant proteins is fundamental to modern biotechnology. Unfortunately, proteins are often difficult to express outside their original host or to over-express even within their native host. Different genes encoding the same protein can express at very different levels. Altering the coding sequence to increase protein expression is highly cost-effective, providing the re-coding is done correctly according to scientifically researched algorithms, not just the guess work or disproved theories other companies use!
ATUM: Scientific Research and Algorithms, NOT Guesswork
ATUM has extensive expertise with machine learning algorithms for the deconvolution of multivariate data. Generally we use these to engineer proteins, designing changes to the amino acid sequence so that the protein's properties are better suited to a desired human application. We used identical algorithms to see whether we could identify a property of the DNA sequences of our synthetic genes that correlated with expression. Although there was no correlation between expression and the CAI score of a gene, we did find a strong correlation with the use of certain codons.
Designing, synthesizing and expressing systematically varied sets of genes encoding two different proteins has enabled ATUM to identify codon usage within a gene as the critical determinant of protein expression levels in E coli. This research proved that codon biases of natural genes does not help maximize expression from synthetic genes. Using a genetic algorithm to select partial least squares regression models, we found that the frequencies of about 15 critical codons, encoding 6 or 7 amino acids, were very good predictors of expression. From this data ATUM has developed gene design algorithms which produce maximal protein expression.
Host Bias or High CAI? Strategies that Never Work
In the absence of experimental data, gene designs have been based either on extrapolations from what is seen in nature, or on what can be easily calculated. Codon frequencies vary significantly between different organisms, and between genes expressing high or low levels of protein within the same organism. Gene Synthesis companies assumed that they could use the codon frequencies from natural highly expressing genes to guide the choice of codons when designing synthetic genes (our competitors still do this).
- Codon Sampling makes the gene "look like" an average gene from the expression host.
- High Codon Adaptation Index (High-CAI) makes the gene "look like" a highly expressed gene from the expression host.
- RNA Structure Minimization reduces or eliminates mRNA secondary structures.
It is clear, that for both of these genes, there is no correlation at all between expression of a synthetic gene and high CAI nor its 5′ mRNA structure.
This technology is partially covered by US patents 8401798, 8126653, 7561973, and 7561972 issued to DNA2.0 / ATUM.
GeneGPS® Algorithms can Optimize Expression in Your System.
ATUM has employed a variety of multivariate analysis strategies to identify relationships between gene design variables and protein expression. We have ongoing studies in Bacteria, Yeasts, Mammalian cells and in vivo, Plants, Fungi, Insects, and Cell-free systems. ATUM is using the results of our research to create patented gene design algorithms for numerous host systems. When utilized, these new GeneGPS® design algorithms routinely produce 10-100 times more protein than competing codon optimization methods. Results from these investigations can be seen in ATUM PepTalk 2016 Presentation and from the links below.
Synthetic Genes have Enormous Advantages over their Natural Counterparts
- Obtained more quickly and less expensively than conventionally cloned genes
- Simple to modify in order to facilitate downstream manipulations
- Opportunity for vastly improved protein expression
- Any sequence you can imagine is available
Not all Synthetic Genes are Created Equal
Synthetic Genes are now generally obtained more quickly and less expensively than conventionally cloned genes, but not all synthetic genes express equally well.
Better Protein Expression than Native Genes
A successfully optimized synthetic gene can cause a single polypeptide to represent 10 to 50 percent of the host's total protein. These levels are generally between 10- and 100-fold greater than the yields from native genes. Much more protein can be expressed from a redesigned synthetic gene than from the original because native genes have evolved for balanced expression of all cellular genes, not for maximal expression of any single gene.
Save Time and Money Compared to Conventionally Cloned Genes
It costs you less to order a synthetic gene from ATUM than it does to purchase the oligos and molecular biology kits, and to include the labor costs and sequencing of conventional cloning. The promise of greater protein expression delivers a major additional benefit: you spend less time and money struggling to produce a protein, leaving more energy and resources to focus on study or application of the protein itself. Your efforts are concentrated on the real goals of your research.
Freedom of Design
Gene synthesis allows you the opportunity to design, clone and express in powerful new ways, even design sequences de novo without being limited by what nature can provide.
- Optimize for recombinant protein expression in any organism using multiple codon optimization algorithms
- Remove or add restriction sites or other sequence motifs
- Recode open reading frames, check translation frames and fusion junctions
GeneGPS™ Overview
Webinar: Optimizing Gene Expression and Performance using GeneGPS™
Gene synthesis allows researchers to tailor gene sequences for optimal utility for any application. However, the relationship between gene sequence and expression is complex and depends on a wide range of sequence variables. ATUM uses a systematic engineering approach, GeneGPS, to navigate these variables with a minimal number of test genes to optimize performance. Application of this approach with a variety of protein targets and expression hosts will be described.
View a pdf of the webinar slides.
Aldevron Webinar – Optimizing Gene Expression/Performance using GeneGPS™
Gene synthesis allows researchers to tailor gene sequences for optimal utility for any application. However, the relationship between gene sequence and expression is complex and depends on a wide range of sequence variables. ATUM uses a systematic engineering approach, GeneGPS, to navigate these variables with a minimal number of test genes to optimize performance. Application of this approach with a variety of protein targets and expression hosts is described.
View a pdf of the ATUM webinar slides.
ATUM Presentations from Scientific Conferences
- Peptalk, 2016: Engineering Biological Systems from Genes to Genomes
- PEGS, 2015: Quantitative Biology – Tools to Build Better Biology
- PepTalk, 2015: Comprehensive Engineering of Biological Systems
- PEGS, 2014: Systematic Optimization of Therapeutic Protein Production
- PepTalk, 2014: Leveraging Gene Synthesis for Systematic Optimization of Protein Production
- Autodesk Ideas Conference, 2012: Gene Synthesis + Machine Learning = BioDesign
- ATUM Pfenex Boehringer Ingelheim Collaboration Case Study/White Paper


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Target to Ramp Up Skin and Hair Care Selections (Yay!)
(Photo by Getty)
Target shoppers, rejoice! In the midst of a massive beauty revamp — have you noticed any changes at your local bullseye lately? — the big-box retailer is now setting its sights on the skin and hair care aisles.
According to a report in WWD, Target plans to start "reinventing" these product categories next month, marking the beginning of a much "more expansive evolution" that's to come in 2014.
In short, more luxury brands and more innovative products (namely anti-aging stuff) will be added to shelves.
"We feel that [hair care is] one of the categories where some smaller brands, premium brands, will complement our assortment," said José Barra, senior vice president, merchandising, of health and beauty at Target. "There are still some pockets where we're not serving the guests [his word for customers] as well as we want. A lot of the new developments are aimed at an older demographic."
Target also plans on expanding its Beauty Conceige program — which is basically a glorified department store beauty counter that comes equipped with a beauty-specialized salesperson. Currently the program's only available in Chicago.
In our minds, we feel like Britney Spears — who's an avid Target shopper, you guys— is probably off somewhere cheering all like, "Gimme, gimme more" right now.

subset: commoncrawl


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"Like having a personal trainer, but on your phone, not theirs."


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Rapid retreat of Chile glacier captured in imagesSANTIAGO, Chile — Researchers in Chile released a series of time-lapse photos Wednesday showing the dramatic retreat of a glacier in Patagonia.
The Jorge Montt Glacier is shrinking faster than any other in Chile, with its snout retreating 1 kilometer (more than a half mile) between February 2010 and January 2011, glaciologist Andres Rivera said.
Rivera said that global warming is a factor and that the glacier also is melting especially quickly because it partly rests in the waters of a deep fjord.
Researchers presented a video showing the glacier's yearlong retreat through a total of 1,445 time-lapse photos. It's one of various similar projects by researchers around the world documenting the loss of glaciers.
Rivera has studied dozens of glaciers as a researcher at the Center of Scientific Studies in Valdivia, Chile. He said he and his colleagues didn't know how rapidly the glacier was shrinking until they put up two cameras with solar panels to charge the batteries and programmed them to shoot four frames a day.
"It was more or less clear that this was one of those retreating most quickly. But we didn't expect in the year of working with these cameras that it would retreat a kilometer more. That was a surprise," Rivera said in a telephone interview. "This glacier is filled with surprises for us."
The glacier is about 1,800 kilometers (1,100 miles) south of Santiago in the Southern Patagonian Ice Field, which blankets a wide swath of the Andes between Chile and Argentina.
"Patagonia has experienced climate changes at levels much more moderate than those observed in the rest of the world," Rivera said at a news conference. "However, almost all the glaciers of the region have lost area, and Jorge Montt is the one that has the record retreat."
The researchers believe that based on a map from 1898, this glacier has retreated roughly 12 miles (19.5 kilometers) since then, Rivera said.
It is a tidewater glacier that calves and releases icebergs as it advances into the fjord.
"Such glaciers typically do retreat in response to warming. But the speed of the retreat is controlled by the ability of icebergs to break off in the fjord, not by the rate of warming," said Richard Alley, a prominent glaciologist at Penn State University.
Rivera agreed, saying that he thinks climate change is the key trigger and that local conditions at the glacier are also having a big impact. He said his team measured the fjord's depth at about 1,300 feet (400 meters) in places, which was considerably deeper than they had thought.
The retreat rate of the glacier "is quite exceptional," said Michel Barer, a researcher at McGill University in Montreal who has studied the melting of Peruvian glaciers.
Barer and other glacier experts at a conference of geophysical scientists in San Francisco said the fastest retreating mountain glaciers are probably somewhere in South America or maybe the Himalayas.
"We see steady but accelerating retreat of glaciers" in the tropical Andes, Barer said. His calculations show that those glaciers are losing 1 percent of their water a year.
According to a recent study by British and Swedish scientists who analyzed about 350 glaciers in Patagonia, all but two of the glaciers have receded significantly since the late 1800s and have been shrinking at a faster rate during the past three decades. The study was published in April in the journal Nature Geoscience.
Neil Glasser, a British glaciologist and one of the authors of the study, said he has also noticed in satellite images over the years that the Jorge Montt Glacier has been shrinking unusually quickly.
"We know that many glaciers in South America are retreating, but this one is retreating ten times faster than the land-based glaciers. It shows how sensitive calving glaciers are to warming atmospheric (conditions) and ocean waters," Glasser said.
He said other tidewater glaciers have quickly retreated in places such as Alaska and Greenland, but the Chilean glacier is one of the best examples in South America.
Patagonia's mountain glaciers are so colossal, and fed by so much snowfall each winter, that scientists believe they aren't in immediate danger of vanishing in the coming centuries.
But elsewhere, scientists expect glaciers to dwindle. Western Canada, for instance, is losing its mountain glaciers and many of them are likely to disappear in the next century, said Garry Clarke, a professor of Earth Sciences at the University of British Columbia.
Report by : AP


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Dr. Gary L. Wolfram
Hillsdale College
Dr. Gary L. Wolfram, an adjunct scholar at the Mackinac Center for Public Policy, is a professor of economics at Hillsdale College in Hillsdale, Michigan, and president of the Hillsdale Policy Group, a consulting firm specializing in taxation and public policy analysis. He is the author of A Capitalist Manifesto: Understanding the Market Economy and Defending Liberty (2012).
His government experience includes a stint as Washington chief of staff for Michigan Congressman Nick Smith, being senior economist for the Michigan State Republican policy staff, and serving as Michigan's deputy state treasurer for taxation and economic policy.
One of the highlights of Wolfram's government service was directing the establishment of Michigan's Enterprise Zone legislation. He also served as chairman of the Headlee Amendment Blue Ribbon Commission.
Dr. Wolfram earned his Ph.D. at the University of California-Berkeley, and he has taught at several colleges and universities, including Mt. Holyoke College, The University of Michigan, and Washington State University.
From Dr. Gary L. Wolfram
Auto Insurance Reforms a Good Start
Reforming Michigan's Auto Insurance Industry
Rather than attempting to regulate insurance company and individual behavior, Michigan legislators would much better serve the people they represent by examining why insurance premiums are so high in the first place, in order to address the problem at its source. A careful study of Michigan's insurance market and the regulations governing it indicates that no-fault insurance and the legislative requirement for individuals to purchase unlimited personal injury protection are two important reasons for the increased costs of providing insurance coverage in Michigan. The good news is that it is possible to reduce these costs and reduce the number of drivers who take the risk of violating the law and do not purchase insurance. … more


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I was working with the simulation model for intelligent vehicle last night using just basic components like the infrared LEDs and LDRs to developed a program that would avoid the rear end collisions in car. Using just one OpAmp in comparator mode, I linked the car models with the computer program developed on VB and able to get 2 detecting ranges to keep track of the two cars' distance. However, I found out something so strange about using parallel port that is it works differently (more precise I guess) if you join its ground pin to the ground of the external circuit. I tried not joining them; it gave almost the same result of the input reading but in a not very stable manner... I kinda repeat it several times to confirm this phenomena, and yes it is. Does my printer port has something wrong in it?
Can anyone suggest me the site where I can find more detail about some simple or homemade kind of sonar? Love to have it. thanks kittipat_0541(at)yahoo.com


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Miley Cyrus' 'LOL' Gets Limited Release
Her movie may be called 'LOL,' but we don't think Miley Cyrus is laughing at this news. The 'Can't Be Tamed' singer's upcoming film is slated for a limited theater release.
Sources told the Los Angeles Times that the movie's production company, Lionsgate, isn't confident that it can sell the film well as a wide release. Following two flops ('Abduction' and 'Conan the Barbarian') and the massive success of 'The Hunger Games,' which stars Cyrus' boyfriend, Liam Hemsworth, the studio's priorities have shifted away from the mother-daughter teen comedy.
It can also be noted that costar Demi Moore's recent rehab stint, along with Cyrus' own recent mishaps, likely didn't help the marketing campaign, either.
In fact, Lionsgate didn't want to release the film until after 'The Hunger Games' hoopla died down — and even considered sending it straight to DVD, but contractual clauses with Mandate Films, the Lionsgate subsidiary that produced the movie, required it to be shown in at least 100 U.S. theaters. The film will be released in seven cities only on May 4 — the same weekend as surefire blockbuster 'The Avengers,' starring Liam Hemsworth's brother, Chris – and with minimal press accompanying it.
It's a pretty raw deal considering Cyrus has proven to have a pretty good box office record. Her two 'Hannah Montana' films each grossed close to $70 and $80 million, respectively, and her tearjerker, 'The Last Song' (where she met Liam!) earned $63 million.
Hopefully Cyrus' summer film, 'So Undercover,' in which she co-stars with Kelly Osbourne, fares better.


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Total Commander (64-bit) v9.21a
Vista / Win10 / Win7 / Win8 / WinXP
Total Commander has internal unpackers for ZIP, ARJ, LZH, TAR, GZ,CAB, RAR and ACE formats and also additional packers can be added as plugins. The build-in FTP client supports most public FTP servers and is able to resume aborted downloads, handle archives and can send files directly from one remote server to another. Total Commander has a lot of nice features that will help in file handling tasks as well.
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Teacher Training: Plumber's Apprenticeship?
#1 Guest_andy_walker_*
Posted 21 January 2004 - 09:42 PM
My view however is that these trends will inevitably have undesirable consequences on the quality and commitment of newly trained teachers and are part of the deskilling of the teaching profession which gathers apace day by day and actually nears completion.
Not withstanding the undoubted fact that teachers trained using the school based approach will be well equipped to deal with classroom management issues and probably armed with one or two behaviour management strategies gleaned from a few staffroom old lags, we are selling ourselves very short indeed if we believe that what emerges is a qualified teacher.
A properly educated teacher needs an understanding of the context in which they work. To achieve this it is essential that they understand the history and sociology of education and indeed understand the sociology and politics of staffrooms. A properly educated teacher also needs an acute understanding of how children learn and of comparative teaching methodology. To achieve this they must have grounding in the psychology of learning and the philosophy of education. This is not something that can be realistically achieved on what amounts to an extended teaching practice supervised by a subject mentor. It is utterly bizarre that as I type this I know that it will be a highly controversial viewpoint.
What it all boils down to is essentially the old education versus training discussion. Training is what I do to the clematis in my back garden. I train it to behave in a particular way in a particular set of circumstances year on year. In the case of my clematis to grow up my fence and to flower prettily in May. In the case of the trained teacher dare I say it might be to produce the same lesson objectives, same plans and plenaries lifted from the myriad of DFES documentation year on year, class by class.
An educated teacher however will have flexibility, purpose, vision, understanding and I would presume to suggest a little healthy cynicism of what is thrust before him or here. They will understand the nature of the institution, in which they work, may have a commitment to its aspirations, they will understand current debates and controversies in education and be able to question Orthodoxy, they will understand how children learn and may even have the counselling skills to deal with teenagers. Most importantly of all they will have some inspiration of why they have chosen to become a teacher and what they hope to achieve. A priceless asset in what could be a 35-40 year career, which will sustain them long after formulaic lesson plans from the centre are forgotten and unfashionable.
The logical final expression of the victory of training over education in teacher training can be seen in recent government proposals to allow unqualified non graduates to take whole classes in state schools. Surely it is here that we see the final nail in the coffin of the profession anyone can teach it just takes a few weeks practice in a school, after all it is just delivering what someone else has planned for you is it not?
Posted 21 January 2004 - 10:39 PM
I do feel in many ways my training did not prepare me for full time teaching (Then again................what could?) . I do feel that we were trained to follow current standard procedures but there was little academic content (psychology, philosophy and so on). No real debate at all unlike when I did my degree. I found this a shame and not inspiring.
This is not to say that I did not get excellent support and learn from people I worked with on placements.
H. G. Wells
Posted 22 January 2004 - 01:45 AM
I'm not entirely sure that I fully understood the value of the psychology,sociology, philosophy and history of education courses at the time. In fact I can clearly remember that our (students) chief criticism of the course was that there were few 'tips for teachers' on classroom management and the like.
However looking back over my career I know that in the long run my tutors were right. What sustained me was the vision for education they helped me to develop. I doubt whether the conviction that teachers are trained rather than educated will serve the current generation of trainees so well.
Posted 22 January 2004 - 12:46 PM
Attract better quality teachers to the profession.
Posted 22 January 2004 - 02:19 PM
Surely its appropriate and neccessary to provide new entrants to any profession with a sound understanding of the philosophical frameworks within which they are to be expected to work? education is an area in which there are umpteen different pedagogical approaches, there is a plethora of information based on quality research about learning styles and equally as much 'academic' study into the types of skills that need to be developed and the best manner by which these can be cultivated.
I found it an utter waste of time to have someone who had been out of the classroom for donkeys of years preaching their educational philosophy to me.
I'd agree that as a student it often seems that these aren't particularly relevant, indeed at times learning these is downright boring. Not understanding them though results in a teacher having a very limited breadth of understanding of the educational system in general and the different appraches to teaching and learning that can, and should, be adopted.
The classroom is very much the place that you'll learn the trade in terms of classroom management etc. but once you've got a firm grip on that one aspect of teaching, what next? Where do you take your teaching? Once the little dears will sit, listen, jump or whatever when you want them to do it , its neccessary to start applying the ideas and pedagocial theories learnt in these 'preaching sessions'.
I've worked with both PGCE students following a more traditional type of course and alongside a variety of GTP teachers (varied subject areas). Whilst the enthusiasm has been very much the same, the level of understanding of some of the elementary basics has bene vastly different. That first term of lecture after lecture on the PGCE course has clearly led to them understanding a variety of concepts that the GTP students haven't even heard of when they land in a classroom. Little things such as Why do we assess?, How can we assess?, What should we do with assessment results? These are hardly areas of irrelevance, are they?
I suspect that this aspect of your course wasn't delivered in a particularly interesting manner. taught well it should appear relevant, interesting and of great significance.
Posted 23 January 2004 - 07:01 AM
When I did my PGCE course in 1977-78 I had four PGCE tutors. Two were very poor, one was good and the final one was brilliant (Stephen Ball of Beachside Comprehensive fame). Stephen provided what Andy has so rightly pointed out is so important in a PGCE course. He helped me understand the history and sociology of education and indeed understand the sociology and politics of staffrooms. He was also an excellent teacher himself. To quote Andy again: A properly educated teacher also needs an acute understanding of how children learn and of comparative teaching methodology. To achieve this they must have grounding in the psychology of learning and the philosophy of education.
I found that the only useful part of my training (about 6 years ago) was the teaching practice. The rest was frankly bo***cks. The fundamental problem today is that institutions do not or are unable to attract deecnt candidates on to pgce courses. So we have a situation whereby the standards are being diluted. If someone has got the ability to be a good teacher then they need to get into a series of schools and gain experience (accompanied by good support from tutor and mentor.) I found it an utter waste of time to have someone who had been out of the classroom for donkeys of years preaching their educational philosophy to me.
When I was training at Sussex University it was the policy of the course to insist that for the first two weeks in the school, you would spend your time observing teachers in the classroom. I have to admit that a higher percentage of the tutors at the university were good teachers than at the school where I did my training.
However, I found this process extremely useful as it helped me work out the style of teaching that I wanted to adopt. For example, there was one teacher who I liked a great deal. We both came from the same background (working class, late entrants to teaching) and shared a similar political and educational philosophy. He believed passionately that he was doing the most important job in the world and cared deeply about the pupils he was teaching. He was also extremely well organised and had a reputation for getting good exam results. However, I made no attempt to adopt his style of teaching. The main problem was that he had a very authoritarian approach to teaching. This was a style that most teachers urged us to adopt. The most common phrase I heard from teachers during that first term was dont smile in class until Easter. (The more liberal ones said Christmas). This view was reinforced by what we were being told at university (to obtain good discipline you need to develop a mask of authority, etc.). My personality (and political philosophy) meant that this was for me an impossible thing to do.
Luckily, I also observed a teacher who had a style that fitted in with my own philosophy of education. Discussions with him later showed that this was no coincidence as we both had the same set of values. Of course, you cannot just develop a teaching style by watching a good teacher in the classroom. What was important was that he showed me what was possible. I only watched him teach two lessons but he generously gave me a great deal of his time to discuss the process of teaching.
My advice to any PGCE student is to first develop a philosophy of education (one of the things that disturbs me is the large number of students who dont seem to have one). Then find a successful teacher in the school who appears to share your philosophy. Then ask them if you can observe some of their lessons. If they refuse, they were not the right person to ask in the first place.
My concern is that many teachers take advantage of PGCE students. Some teachers do unfortunately see it as an opportunity to get the student to take difficult classes from them. Although it gives them short-term respite from their troubles, their original problem does not go away. In fact, it becomes worse, especially if the student successfully develops a good relationship with the class.
There are other teachers, who although competent classroom teachers themselves, have no strong desire to help others develop these skills. As I said in a discussion on the Education Forum, the most important character trait in a good teacher is generosity.
There are plenty of teachers who have a committed philosophy about teaching and are willing to use what influence they have to obtain converts to the cause. These teachers can also be a problem. Especially if they have a philosophy you do not share.
When I first left school I became an apprentice in the printing trade. Even though this was a purely practical trade, it was considered to be vitally important to spend one day a week at college. This went on for 5 years. I would argue that this one day a week at college was just as important as the four days a week spent on the shop floor. This course encouraged us to ask why experienced printers did things in the way that they did. It taught me that experienced workers do not always get it right. That being taught on the job can be very dangerous as it can often involve teaching bad practices that have been ingrained in the profession. This applies to teaching far more than it does to the printing trade.
Edited by John Simkin, 23 January 2004 - 07:23 AM.
Posted 25 January 2004 - 12:49 AM
For me personally the PGCE was summed up by a teacher at the Primary school I went to observe in before starting the PGCE. This was a teacher I'd respected and enjoyed being taught by when I was at the school and he simply said that the time in the lecture theatres was useful, but you only really began learning when you were in school. You then only begin really learning when you've completed your PGCE and have your own classes, and you never really stop learning....
It's perhaps a bit pompus to suggest that teachers should have an educational 'philosophy', but your aims and understanding of the profession certainly change as you work through the PGCE. Currently the PGCE is very much an experience where you get everything thrown at you - philosophical, educational, phychological and practical - and you simply don't have time to take it all in or appreciate anything. The PGCE was very well summed up by a recent comment in the new teachers' section of this forum:
Woohoo, Christmas. I am so tired I could quite possibly sleep through it all! Its been a pretty manic term- lots of work, stresses, and a few good laughs. I was quite choked up on my last day when the department gave me a thank you card for all my efforts and a mug (indispensable for next practice!). It was a great school, the support was brilliant and I even grew to love some of the kids. My assessments all went pretty well and I only made one boy cry which can't be too bad!! Handed in my bloody assignment in time too (miracle! I really can't see the point in it but there you go)
The current PGCE is very much about survival - there's little time for anything, be it educational philosophy, practial 'on-the-job' training or anything else. You just get lumbered with an enormous amount of paperwork and demands which seemingly prepare you for what awaits you in your career.
John's got it right that teachers need to be generous....
Generate your own versions of my games, quizzes and eLearning activities: ContentGenerator.net
#8 Guest_andy_walker_*
Posted 25 January 2004 - 08:14 AM
I was wondering whether anyone would see fit to argue the case for the "school based model". It must by definition have some sort of philosophy behind it other than the obvious one that it is a very cheap way of "training" teachers. Incidentally I can only see yet cheaper techniques being used with the recent introduction top up fees. If doctors are worried about the debt they will be in, god help the teachers
It is an interesting series of points that Andy makes. Trouble is, there is very little to argue with or disagree.
Posted 26 January 2004 - 01:28 PM
I particularly liked the comment
Attract better quality teachers to the profession.
The history course here (at Swansea) always receives more applications than places so the standard is reasonably high and we are all history graduates (perhaps with the exception of one or two mature students, I'm not sure). However on the maths course I know with authority that only a handful are maths graduates, some do not even have degrees. I appreciate that good subject knowledge doesn't mean that you are a good teacher but surely children deserve someone who knows what they are talking about to a high level.
It depressed me that when applying for this course around last easter Uni friends said to me "surely you can do something better than teaching with your degree?" (for the record, a 2:1 in history and politics from York). Maybe I can do something better paid and (today) better respected. But I don't think I could do anything more rewarding and worthwhile.
"We are stardust, we are golden, we are billion year old carbon"
Posted 26 January 2004 - 05:12 PM
The silence is deafening. I am sure cheapness is the only argument that can be put forward. However, it is not actually cheaper because there is a bound to be a larger drop out rate. I suspect that Blair, like Thatcher, is trying to reduce the influence that tutors at university have on what goes on in the classroom. From my experience, they tend to be more progressive in their views than most classroom teachers. Thatcher used to rant on about the educational establishment undermining her reforms. I suspect that Blair and Clarke feel the same way.
I was wondering whether anyone would see fit to argue the case for the "school based model".
Posted 26 January 2004 - 05:57 PM
I believe that the only reason this worked as well as it did was because of the expanding nature of the school at the time: we were always going to be overstaffed for a period of 12 months and this enabled things such as team teaching, intense monitoring and evalaution and a range of training exercises being built into her weekly and half termly programmes. This is far removed from the experiences of several other people I have worked with. Two former teaching assistants have now gone to local schools to take up GTP positions. Both have been given a 80% timetable, 1 hour a week of mentoring (in which the mentor can be taken for cover) and fortnightly training afternoons run for them by some training provider or other. They seem to receive more support from fiends they acquired as support assistants than they do from the training providers. They haven't had any in depth training with regards classroom management, the National Strategy (one teaches Maths!), effective use of ICT, educational philosophy, erm, anything really. This a crying shame as both of them had the potential to go on to become enthusiastic and effective teachers. Whilst they are still both extremely enthusiastic, they themselves recognise that they're development is lacking in several key areas and it will take them longer than desired to become truly effective classroom teachers. At least PGCE students have the opportunity to be put in the frying pan before being tossed into the fire - this lot appear to be dumped in the deep end without so much as a paddle in many schools.
What about continued training of teachers? How effective is the provision of CPD for new entrants to the profession? For those wanting to progress to Middle or Senior management roles? What training exists for people who simply want to stay in the classroom and continue to do a good or better job? In many professions you are required to have regular CPD in order to maintain your registration - the ones teachers cite when in pay round talks. Should this be a requirement within the teaching profession?
#12 Guest_andy_walker_*
Posted 26 January 2004 - 06:58 PM
Not sure about compulsion but one fundamental weakness of the INSET opportunities for many teachers in todays schools is that CPD becomes available only when it fits into or informs the School Development Plan rather than the professional needs/desires of the teacher. These do not always coincide.
What about continued training of teachers? How effective is the provision of CPD for new entrants to the profession? For those wanting to progress to Middle or Senior management roles? What training exists for people who simply want to stay in the classroom and continue to do a good or better job? In many professions you are required to have regular CPD in order to maintain your registration - the ones teachers cite when in pay round talks. Should this be a requirement within the teaching profession?
We too have a number of GTP student teachers training with us. We offer more free time than most schools, and have also set up a programme of Education lectures and seminars at local providers. We really are however making the best job of an ill conceived scheme.
I am genuinely surprised that no one has yet has come up with an argument in favour of school based TT other than its cheapness or with reference to how "naff" their College lectures were.
Perhaps our professional associations should be more proactive in establishing some degree of control over entry to the profession?
Posted 26 January 2004 - 09:30 PM
However the flip side of this is that they are unlikely to be as well versed in the philosophy of education. The GTP course does not build in adequate educational philosophy studies. The practical focus of the course does enable GTP students to avoid becoming well versed in educational psychology and ideology. The PGCE course delivers this.
So perhaps the argument is about short term gain for long term loss. Of course all of this is genearlised as a PGCE student may do little professional studies reading, and a GTP student may go off and do much more of their own accord. It would be interesting to interview a sample group of teachers in say their third or fourth year of teaching to complare their approaches, skills and understanding of complex issues of pedagogy and psychology.
From my personal perspective I remember thinking very negativiely about large parts of my PGCE course. I remember sitting in the lecture hall wondering why on earth I needed to know about the history of education in the UK for the last 100 years to help me teach in a classroom. I remember being totally indifferent to the psychology and philosophy lectures I felt forced to endure. I sat thinking to myself that the person giving these lectures had no idea what it was really like out there in the "real" world of the classroom.
The first couple of years of teaching seemed to simply reinforce this view in me. Teaching was about getting on with the job, getting the children through and delivering the expectations of all those who have a stake in each child's education. The relevance of the theoretical stuff did not strike me at that time, and I actually resented being forced to sit through the turgid lectures of some so called expert in educational philosophy.
In the last three years I have increasingly come to recognise the value and importance of this knowledge. As I have settled into a more developed understanding of my role and how to deliver my teaching, I appreciate the philosophy and pedagogical training that I recieved. More and more of the parts of my PGCE that were not spent on teaching practice come back to me and help me to plan and develop my lessons and teaching.
Therefore I concur with others that the GTP route does not deliver the fully rounded teachers that are needed for the modern classrooms. This does not mean however that I am prepared to totally oppose the concept of "on the job" training delivered in schools away from a teacher training institution.
What is needed is some form of balance between the two. Teachers training using the GTP route need to be required to cover much more of the philosophy and pedagogy of the PGCE course, but this can still be delivered using the GTP route. What we need is to create the classroom assurance of a GTP teacher with the added wisdom of a PGCE educational philosophy education.
I see no reason why the training of teachers should be left solely in the hands of the professors in the universities, but I would also wish to see their role maintained where it is necessary. Perhaps LEAs need to be given the funds to buy in lectures from experts for all of their GTP teachers each year. A program of monthly lectures and seminars held in LEA training centres to give the bigger picture beyond the single school could deliver this.
I am not shouting the argument for the GTP in its present form, but I still do not totally accept that the PGCE is the only route that can deliver excellence in teacher training.
Posted 26 January 2004 - 10:05 PM
#15 Guest_andy_walker_*
Posted 26 January 2004 - 10:32 PM
I am not shouting the argument for the GTP in its present form, but I still do not totally accept that the PGCE is the only route that can deliver excellence in teacher training.
My basic criticism is that all teacher trainees whether they do GTP, SCITT, PGCE or B Ed (in descending order of crapness) are under prepared for the role that awaits them given that the fashion within all teacher training is towards "on the job training" over academic discipline and reflection.
Would we accept doctors and solicitors who had trained by "having a go" themselves over an extended period? I for one would prefer someone who had undertaken some study
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Lot # 227 (of 1727) < Previous Lot | Next Lot >
1913 WG6 "Tom Barker" Game Cards Complete Set (54)
Starting Bid - $500, Sold For - $2,938
Complete set of all fifty-two 1913 "Tom Barker" cards, accompanied by two original score cards, for a total of fifty-four cards. This set was consigned directly from the family of the original owner, who played with this set in 1913! The "Tom Barker" game card set is comprised of forty-three different individual players and nine action photos. Nearly identical in design to "The National Game" card set except for the different back design in red which features a batter and advertising for "Tom Barker Baseball." In our experience, "Tom Barker" cards are considerably rarer than "The National Game" style cards. Many great stars of the era are represented, including Joe Jackson, Ty Cobb, Honus Wagner, Walter Johnson, Christy Mathewson, Nap Lajoie, Tris Speaker, Cy Young, and many more. Forty-two cards range from Vg-Ex to Ex condition, ten cards are Vg including Joe Jackson, two slightly lesser. This is a very attractive set which has not been mishandled in any way, but has been played with as intended. These decks occasionally survive in perfect condition, with cards having never been used for play, and those decks are now selling for many thousands of dollars. A very consistent medium-grade set such as this is rarely offered and represents an outstanding value compared to higher-grade sets, and perhaps all other 1910-era baseball sets as well! Also included are the pieces to an original box (it has essentially disintegrated). Total 54 cards. Reserve $500. Estimate $1,000/$1,500. SOLD FOR $2,938
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TROY, N.Y. – The MIT men's track and field team successfully defended its title in the annual Engineer's Cup competition, as the Cardinal and Gray totaled 176 points to best host RPI (133) and WPI (96). The men would win seven of 11 events on the track, in addition to three field events, en route to the team victory.
Stephen Morton and Paul Welle helped lead the way for the Engineers, as both won multiple individual events, while Morton was also part of the victorious 4x100-meter relay. Morton, sitting out the 100-meter dash, was still able to take first place in the 200 meters (22.67 seconds), as well as the long jump (23-1.75 feet) and triple jump (47-1.50 feet). Morton's efforts in both jumps were good enough to reach the NCAA Provisional qualifying standard.
Welle moved from the Steeplechase, an event in which he has already provisionally qualified for the NCAA Championship, to the 1500m and 800m, coming away with two wins. Welle led a sweep of the top four for MIT in the 1500, finishing in 4:05.72. Richard Prevost (4:06.40), Benjamin Mattocks (4:08.11) and Hemagiri Arumugam (4:09.87) followed to help rack up valuable points for Tech. Welle, Stephen Serene and Bill Phipps then combined to go one-two-three in the 800, with Welle coming through first in 1:58.89.
The Engineers' other winners on the track included Patrick Marx in the 400m, with a time of 50.36 seconds, Rene Peters in the 100m (11.07) and Yermie Cohen, returning to run at 5000 meters in 15:36.49.
In addition to Morton's two victories in the jumps, James Oleinik picked up a win in the shot put, with a toss of 48-7.25 feet, helping MIT sweep the top four in that event. Greg Tao was one of two pole vaulters to clear 15-9.00 feet, a provisional qualifying mark, but finished in second due to attempts.
Tech will hosts its first home meet of the outdoor season next weekend, welcoming in Bates, Colby and Southern Maine on Saturday, April 10 beginning at 12:00 p.m.


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Friday, October 25, 2013
Washington Avenue Armory
195 Washington Ave.
Albany, NY
or call the Armory at 518-512-5203, M-F 9 a.m. to 6 p.m.
ARES Promotions provides promising professional boxers a platform to showcase their talents
and advance their careers. Formed of local entrepreneurs and boxing enthusiasts, ARES shares
its passion through events that bring high-quality entertainment to area residents and visitors.
We strive to take local boxing to a new level and expand the sport's growing fan base. We look
forward to seeing you at our next show!


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Hurricane Harvey & Helping Your Child Cope With Natural Disasters
On August 25th, Hurricane Harvey made landfall along the Texas coast, bringing powerful winds and heavy rainfall with it. After days of non-stop rain, Houston and many other regions were left in shambles, forcing hundreds of thousands of people to walk away from what was once their home. While this devastation undoubtedly affects many people's jobs, daily routines, and mental health, it is important to remember that children are affected as well.
It can be difficult for young children to grasp natural disasters and why and how they occur. Children cope with events such as this differently depending on their age, but they are all susceptible to its negative impact. Whether your child was directly impacted by Hurricane Harvey or not, these tips for coping with natural disasters are sure to help your family move forward no matter what you face in the future.
Talk About It
One of the best ways to help your child process what has happened is by discussing the events that have occurred. Explain the disaster in logical terms so your child can fully understand why or how things have changed. Most importantly, allow your child to express his or her emotions about what has taken place, and listen to their worries or fears. By creating a safe space for your child to share their feelings, they will be less likely to bottle up or hold onto any negative emotions. A wonderful resource on how to discuss natural disasters with children can be found in this Sesame Street episode, where Big Bird's friends help him rebuild his nest after a storm.
Maintain A Routine
Your child can hold onto a sense of normalcy by maintaining their typical routine in whatever way possible. Try to stick with their normal bed/wake up time in order to ensure they're getting enough sleep. Allow them time to learn and play, and stick with any rules you would enforce on a daily basis. Many parents feel the need to coddle children in the midst of a disaster, but sticking to a routine can provide a sense of safety and security.
Be Patient
Remember – each child processes natural disasters differently. While one child may appear totally unaffected, another could display symptoms of anxiety or even depression. Be patient as your little one copes with how their life has changed, and know that it could take weeks, months, or even years for them to fully recover. Love, comfort, and patience go a long way when helping your child move past a difficult time.
Would you like to help Kids 'R' Kids employees who have been affected by Hurricane Harvey? Simply visit our GoFundMe link and make a donation. It is our hope to raise $100,000 or more for all staff members and teachers whose homes, families, and livelihood have been impacted by Hurricane Harvey.


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Kristen Stewart & Garrett Hedlund: 'On the Road' Screening!
Kristen Stewart and Garrett Hedlund attend a screening of their film On the Road on Thursday (December 6) at the Sundance Cinema in Los Angeles.
The 22-year-old actress and the 28-year-old actor were joined by their director Walter Salles at the event, as well as legendary director Francis Ford Coppola.
PHOTOS: Check out the latest pics of Kristen Stewart
In case you missed it, check out Garrett on the cover of Interview Magazine's latest issue, in which he shares his experience of filming the new movie.
FYI: Kristen is wearing a Jason Wu top and shorts with Barbara Bui heels.
15+ pictures inside of Kristen Stewart at the screening…


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WHEAT RIDGE, Colo. - Call it Freedom of Speech. A billboard recently
erected in Wheat Ridge compares President Barack Obama to a terrorist
and questions his U.S. citizenship.
The billboard, located at 4855 Miller Road, shows two cartoonish images
of Obama wearing a Muslim turban and reads "PRESIDENT or JIHAD?"
It also says "BIRTH CERTIFICATE - PROVE IT!" alluding to the conspiracy
theory which claims Barack Obama was born in Kenya rather than Hawaii,
which would disqualify him for the office of President.
The words "WAKE UP AMERICA! REMEMBER FT. HOOD!" appear on the bottom of the billboard.
The sign belongs to a car dealership.
"Since Fort Hood, I've had it," owner Phil West told FOX 31 News
Friday. "You can't suggest things. You can't profile. You gotta call a
spade a spade."
"Everything I have read about Mr. Obama points right to the fact that
he is a Muslim. And that is the agenda of what Muslim is all about.
It's about anti-American, it's about anti-Christianity," West said.
The Anti-Defamation League condemned the sign, as did AM760 radio host
David Sirota, who discussed the sign and interviewed West on his
program Friday morning.
"It's out of control," Sirota said. "This conservative hatred of Barack
Obama is out of contol, and this brings together all those strands of
it: the racism, the anti-Muslim fervor. It's one thing to criticise the
president on health care, or Wall Street reform, or immigration. But
this is outrageous. And I think it's a fair question to ask why these
questions about religion and ancestry are being directed so viciously
at the first African-American President of the United States."
While the ADL issued a statement calling the billboard an exploitation
of the Ft. Hood shootings that is "divisive and offensive, and
perpetuates hateful and harmful stereotypes about Muslims", prominent
conservatives have been silent thus far.
"That could suggest that conservative leaders are afraid to confront
the extreme fringe of their base," Sirota said. "Or it suggests they
actually condone this message. Either way, it's disturbing."
Sirota is an unabashed liberal, but not all self-identified conservatives who drove past the sign Friday disagree with him.
"I'm not concerned with that at all," said Linda Alexander, of Golden,
in regard to the dispute over President Obama's American citizenship.
"He was elected, he's the president -- that's it, as far as I'm
concerned. Some people just can't accept that, obviously."
But Keith Walters, another passing driver, saw nothing wrong with the billboard.
"I can't honestly say he's a Jihadist, but there's a lot of things that
are questionable," Walters said. "The whole birth certificate
controversy. From what I've read, there's no proof Obama isn't a
Muslim. And I don't believe there's any racism [in the billboard]. I
think that should be a question asked to any president who -- they have
some questionable backgrounds."
Supporters of the birth certificate theory, known as 'Birthers,'
believe the Certification of Live Birth produced by the state of Hawaii
is a forgery. (view the birth certificate)


text:
|Publication Type
|Journal Article
|Year of Publication
|Lassen, KG, Kuballa, P, Conway, KL, Patel, KK, Becker, CE, Peloquin, JM, Villablanca, EJ, Norman, JM, Liu, T-C, Heath, RJ, Becker, ML, Fagbami, L, Horn, H, Mercer, J, Yilmaz, ÖH, Jaffe, JD, Shamji, AF, Bhan, AK, Carr, SA, Daly, MJ, Virgin, HW, Schreiber, SL, Stappenbeck, TS, Xavier, RJ
|Proc Natl Acad Sci U S A
|Date Published
|2014 May 27
|Animals, Autophagy, Blotting, Western, Carrier Proteins, Chromatography, Liquid, Crohn Disease, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Gene Knock-In Techniques, Goblet Cells, Mice, Paneth Cells, Polymorphism, Single Nucleotide, Proteomics, Real-Time Polymerase Chain Reaction, Salmonella Infections, Tandem Mass Spectrometry
A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute to pathogenesis have been difficult to dissect given that environmental factors likely influence disease initiation in these patients. Here we introduce a knock-in mouse model expressing the Atg16L1 T300A variant. Consistent with the human polymorphism, T300A knock-in mice do not develop spontaneous intestinal inflammation, but exhibit morphological defects in Paneth and goblet cells. Selective autophagy is reduced in multiple cell types from T300A knock-in mice compared with WT mice. The T300A polymorphism significantly increases caspase 3- and caspase 7-mediated cleavage of Atg16L1, resulting in lower levels of full-length Atg16Ll T300A protein. Moreover, Atg16L1 T300A is associated with decreased antibacterial autophagy and increased IL-1β production in primary cells and in vivo. Quantitative proteomics for protein interactors of ATG16L1 identified previously unknown nonoverlapping sets of proteins involved in ATG16L1-dependent antibacterial autophagy or IL-1β production. These findings demonstrate how the T300A polymorphism leads to cell type- and pathway-specific disruptions of selective autophagy and suggest a mechanism by which this polymorphism contributes to disease.
|Alternate Journal
|Proc. Natl. Acad. Sci. U.S.A.
|PubMed ID
|PubMed Central ID
|Grant List
|R01 AI084887 / AI / NIAID NIH HHS / United States
DK043351 / DK / NIDDK NIH HHS / United States
AI084887 / AI / NIAID NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
K99 AG045144 / AG / NIA NIH HHS / United States
T32 AI007163 / AI / NIAID NIH HHS / United States
R00 AG045144 / AG / NIA NIH HHS / United States
DK097485 / DK / NIDDK NIH HHS / United States
R01 DK097485 / DK / NIDDK NIH HHS / United States
Proc Natl Acad Sci U S A DOI:10.1073/pnas.1407001111
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Recent Broad Publications
News at the broad
News / 09.25.18


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Crew midfielder Chris Birchall was like a little kid on Christmas when he found out he'd be playing against his hometown club Stoke City on his first day of training with the Black & Gold.
"That just made my day," Birchall expressed with laughter upon learning the news back in May. "I just can't believe what you just said, really."
"Stoke is exactly where I lived. I know a lot of the Stoke players," he continued. "I get to share the field with my best friend."
Birchall's best friend is Stoke defender Andy Wilkinson. The Potters' right back seved as Birchall's best man at his wedding back in June and is godfather to Birchall's son, Ashley.
"The chances of (Birchall) coming from the other side of the world to play for a team, then for us through a preseason tour that we've never done before to come and play against him-- the chances are unreal," Wilkinson said after Stoke's Monday training session in Obetz.
The two have know each other since they were six, and have been best friends ever since. Wilkinson says they're both looking forward to getting the best of each other on the field Tuesday night.
"We've only played each other a couple of times," the Potter said.
"If there's a chance for a tackle, I'm sure neither of us will back out," Wilkinson said laughing.
The Crew and Stoke City kick off at 7:30PM EST from Crew Stadium.
For Birchall's take on the match, listen to the latest edition of the Sideline Sit Down.


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It is possible that the main title of the report Oculocerebrocutaneous Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Oculocerebrocutaneous (OCC) syndrome, a rare genetic disorder, is apparent at birth (congenital). The disorder is characterized primarily by eye (ocular), brain (e.g., cerebral), and skin (cutaneous) malformations. For example, many affected infants have semisolid or fluid-filled swellings (cysts) within the cavities of the skull (orbits) that accommodate the eyeballs and associated structures. In most cases, the eye on the affected side or sides is also abnormally small (microphthalmos). Brain abnormalities associated with OCC syndrome may include malformations of the ventricular system in the middle of the brain, multiple fluid-filled spaces within the outer region of the cerebral hemispheres (cerebral cortex), and absence of the band of nerve fibers that joins the brain's hemispheres (agenesis of the corpus callosum). Affected infants and children may also have mental retardation and episodes of uncontrolled electrical activity in the brain (seizures). In addition, OCC syndrome is characterized by underdevelopment or absence of skin in certain localized regions (focal dermal hypoplasia or aplasia) and most have protruding, flesh-colored or brownish outgrowths of skin (cutaneous tags) within certain facial areas, including around the eyelids, on the cheeks, or near the ears. In all individuals with OCC syndrome, the disorder appears to occur randomly for unknown reasons (isolated, with no family history of similar disorders).
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)997-4488
Fax: (914)997-4763
Tel: (888)663-4637
Email: firstname.lastname@example.com
Internet: http://www.marchofdimes.com
International Children's Anophthalmia Network (ICAN)
c/o Center for Devel Medicine & Genetics
5501 Old York Road
Genetics Levy 2 West
Philadelphia, PA 19141
Tel: (215)456-8722
Fax: (215)456-2356
Tel: (800)580-4226
Email: firstname.lastname@example.com
Internet: http://www.anophthalmia.org
Epilepsy Foundation
8301 Professional Place
Landover, MD 20785
Tel: (301)459-3700
Fax: (301)577-2684
Tel: (800)332-1000
Email: firstname.lastname@example.com
Internet: http://www.epilepsyfoundation.org
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
Email: firstname.lastname@example.com
Internet: http://www.ninds.nih.gov/
Anophthalmia/Microphthalmia Registry
Albert Einstein Medical Center
5501 Old York Rd
Genetics Levy 2 West
Philadelphia, PA 19141
Tel: (215)456-8722
Fax: (215)456-2356
Email: firstname.lastname@example.com
Internet: http://www.einstein.edu/yourhealth/genetic/article15698.html
Micro & Anophthalmic Children's Society
PO Box 92
North Wales, LL65 9AW
United Kingdom
Tel: 0870-600-6227
Email: firstname.lastname@example.com
Internet: http://www.macs.org.uk/
MUMS National Parent-to-Parent Network
150 Custer Court
Green Bay, WI 54301-1243
Tel: (920)336-5333
Fax: (920)339-0995
Tel: (877)336-5333
Email: email@example.com
Internet: http://www.netnet.net/mums/
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
Email: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
Internet: http://rarediseases.info.nih.gov/GARD
National Organization for Disorders of the Corpus Callosum
18032-C Lemon Drive
Yorba Linda, CA 92886
Tel: (714)747-0063
Fax: (714)693-0808
Email: firstname.lastname@example.com
Internet: http://www.nodcc.org
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email firstname.lastname@example.com
Last Updated: 4/21/2008
Copyright 1994, 2000, 2003 National Organization for Rare Disorders, Inc.
This information does not replace the advice of a doctor. Healthwise, Incorporated disclaims any warranty or liability for your use of this information.


text: Today, work was initiated on the Axis Processor, an Nth-dimensional real time processing pocket. A processing pocket can be called nearly anytime, within or outside of quadrature. It's power is distributed across a net. The advantage of this particular processor is that it can be represented upon the hardware array while using no hardware. This compresses physical space into that of a few bytes, instead of physical hardware. Specifically, the weight has essentially a zero aspect ratio and the LxWxH consumption is zero. A zero plane element in axis processing is most desireable. I'm really happy with this new development, as it will encompass massive amounts of neural processing power as well as AI crunching and the "zeroeth" dimensional noninhabitation (ZDN), while sustaining the original concepts.


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A woman who died after a fight in a Melbourne hotel car park was stubborn but would never go out of her way to hurt someone, her son says.
Barbara Anderson, 63, suffered head injuries during a fight with another woman in the car park of the Meadow Inn Hotel in Fawkner on April 5.
Detective Inspector John Potter said the two women, who did not know each other, had some form of argument which began inside the hotel.
David Anderson was at his mother's bedside for three days before she died in hospital on April 9.
He said the family needed to know what happened.
He described his mother as an interesting character who was semi-retired and kept busy by doing cleaning jobs and socialising.
"She was stubborn and things like that but no, she's not someone who would go out of her way to hurt someone," Mr Anderson told reporters on Monday.
"That's the hard thing to understand."
Mrs Anderson had dinner with her husband of 32 years, Gary, at the hotel but decided to stay on when he went home.
A devastated Gary Anderson said there were no signs of any trouble before he left.
"It just doesn't make sense," he said.
He described his wife as a "lovely lady, lovely mother, lovely wife".
"It's not easy walking into a house when there's no one there," he said.
Police and the family have appealed for witnesses to come forward, including two men captured on CCTV footage.
One of the men asked hotel staff to call an ambulance, Det Insp Potter said.
"They are not in trouble, they are not involved in this case, but we believe they can help us," Det Insp Potter said.
There was no CCTV footage of the fight itself.
David Anderson pleaded for anyone who saw anything to contact police.
"If you can help in any way just ring up - even if it's something small," he said.
"It's not going to bring mum back but it will give us some form of closure."
Jacinda Mark, 29, of Fawkner, has been charged with manslaughter and other assault-related offences.


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Machine Gun Preacher (US - BD RA)
Gabe wastes his 1000th review watching Leonidas trying to save Kony's kids...
In Pittsburgh, Pennsylvania, addicted gang biker Sam Childs (Gerard Butler) is released from prison. Upon arriving home, he learns that his wife, Lynn (Michelle Monaghan), has quit her job as a stripper and converted to Christianity. Upset, Sam quickly reverts to his old ways, falling back into drugs and crime with his friend, Donnie (Michael Shannon), and eventually killing a drifting hitchhiker. Sam is so profoundly affected by the incident, he lets Lynn and his mother convince him to join their church, where he is baptized. Soon, Sam finds a straight job in construction and begins acting as preacher for the church. After being further moved by another preacher from Africa, he decides to visit Northern Uganda and South Sudan many times, where he builds orphanages for the victims of the cruel Lord's Resistance Army (LRA).
At first glance, Machine Gun Preacher appears to belong on the marquee with post-modern, Grindhouse-inspired joke movies, like Machete and Hobo with a Shotgun, but closer inspection reveals something of an attempt at a minor prestige picture. Machine Gun Preacher is based on a deeply touching (and ongoing) true story that deserves better coverage and it has been brought to life by an incredibly acclaimed director in Marc Forster. It seems that, based on his previous work, Forster's ideal version of this story would work as a meaty hunk of soul-crushing melodrama, followed by a sudden rush soul-affirming sentiment. Something like Hotel Rwanda. But heavy-handed morals are often so exhausting and a cheap, silly shoot 'em up version of recent history would work just as well. The original material probably should be treated with respect, but it has real exploitation appeal. After all, Stallone managed to mix affecting plight and ridiculous violence just fine when he made Rambo a few years ago, proving there's plenty of raw entertainment value in taking the low road with socially important subject matter. Surprisingly enough, Forster aims to mix the low road with the high road. Sadly, it appears Forster isn't the man for this particular balancing act and the efforts largely fall short.
Following critical favourites including Monster's Ball, Finding Neverland and The Kite Runner, Forster found himself lost in Quantum of Solace, the messy second entry in Daniel Craig's James Bond series. Given a bigger responsibility, Forster proved he was not particularly good with cinematic action and big budget scale. Still, it wasn't really surprising that his next film, Machine Gun Preacher, would attempt to blend the based-on-a-true-story esteem of his earlier work with the chaotic action of Solace. His action direction really hasn't gotten much better – it's still so chaotic and senseless that it'll give you a headache – but it fits the material, at least in comparison to a Bond flick. He's also not afraid to earn his R-rating with some really gruesome violence. The frustrating part is that there are glorious moments of clarity and impact within a given sequence, giving a taste of skills learned since Quantum of Solace. The bigger issue is that, tonally, Forster pulls it too far both directions, blindly reveling both in the melodramatic Oscar-bait and the corner-cutting exploitation elements, ensuring that, in the end, neither connect. There's little rush or fright out of the violence and there's no good reason to shed tears for what should've been arresting emotional payoffs.
The problems begin with Jason Keller's screenplay, which is an awkward knot of fumbling, time-skipping narration and cliché driven dialogue. The early scenes of Childers' self-destructing before finding Jesus are absolutely terrible and ridiculously heavy-handed to the point of silliness. The brutality has no bite and the eventual salvation carries zero emotional weight. I appreciate the momentum, but don't see the point in including this stuff when it really has little effect on the bulk of the film's preferred plotline – that of Childers' much more interesting adventures in Sudan. It amounts to yet another should-be interesting biopic hampered by the filmmakers' need to tell more of the story than the film requires. If they'd clipped 35 minutes of fat from the top of their film, Keller and Forster might have at least achieved something similar to Rambo, where the real world cause would've been served by the exploitation appeal ( Schindler's List, in Africa…with a shot gun!), but this is a lump of middle-ground missed opportunity that is somehow both over-indulgent and over-simplified.
Following a rough patch of frankly terrible films, actor Gerard Butler seems to be trying to get himself back on track as a dramatic actor of note in 2011 by starring in Ralph Fiennes' Shakespearian adaptation Coriolanus, and Machine Gun Preacher. Butler himself is one of the film's hundred-thousand producers, which marks it as something of a vanity project, even if he wasn't part of production from the start. The performance is fine, even good when Butler is depending on his charms rather than his teeth-gnashing bite (he's very good when working with the kids), but his accent is all over the place, and there's generally nothing unique about the character. I'm sure the real Sam Childers is a fascinating individual, but his movie equivalent is pretty dull, and blends no shades of grey between his first act blacks and rest of the film whites. He's either a completely terrible, heroin addicted criminal, or a genuine man of God who is only really hampered by the shortcomings of others. He has his third act crisis, but there's never a realistic possibility of his actions having a genuinely adverse affect; he's just having a bit of a temper tantrum. The other actors are given even less to work with, especially Michael Shannon, who plays a composite character that reminds us how far Childers can fall and appears on screen only long enough to remind us that he's sad.
According to the specs, Machine Gun Preacher was shot using mixed 16mm and 35mm stocks. I don't know where things are divided exactly, but rest assured there is some heavy damn grain on this film, regardless of stock used. The point here seems to be grit and grim, so the grain serves the transfer well and is rarely chunky or grotesque. Detail levels are average for type. For the most part, foreground details are sharper than background details, and the tight contrast levels and complex patterns work without shimmering or bleeding. Sequences shot on what I'm guessing is 16mm film feature a bit of edge enhancement, but nothing I'm willing to fault the transfer for. There's a whole lot of color correction going on, which Forster and cinematographer Roberto Schaefer use to separate the different locations. Pennsylvania is largely presented as cool and blue with warm, orange highlights, and Sudan is largely presented as warm and orange with cool, blue highlights. Both palettes are spiked with burgundy and rich green elements. The colours are largely consistent and pure, despite the resolution issues and heavy grain, and black levels are quite deep without any bleeding.
This DTS-HD Master Audio 5.1 soundtrack is not quite as impactful as I was hoping for. The mix leans more to music to create mood than sound effects, and is dialogue heavy for long stretches without any major stereo or directional influence. The dialogue volume levels are a bit up and down. For example, at one point it's almost impossible to tell what Michael Shannon is saying, but the sound of him kissing Madeline Carroll's forehead is crisp and loud. Aural highlights include any scene involving a Harley Davidson motor cycle, a big, throbbing tornado sequence that is almost entirely dependant on sound effects for setting scope and various battle sequence, where gunfire, screams and explosions all feature solid directional movement and effectively heavy LFE enhanced. The musical choices are entirely too obvious, including redneck rock classics and generic 'African' music, but it all sounds warm and sharp, so, for the purposes of the track, it'll work.
The extras begin with Machine Gun Preacher: A Discussion with Marc Forster (18:40). Here, Forster talks about the basic genesis of the project, meeting the real Sam Childers, research, casting, shooting on location, the film's tone, and Childers' reaction to the film. The disc also features Making the Music for Machine Gun Preacher (14:00, HD), a discussion with composers Thad Spencer, Tom Scott and Richard Werbowenki, and editor Matt Cheese about the film's shockingly inadequate musical score, Chris Cornell's 'The Keeper' music video, a trailer, and trailers for other Fox releases.
There's something interesting in the DNA of Machine Gun Preacher, but every turn reveals another missed opportunity. Director Marc Forster fails to mix rollicking violence with harrowing sentiment, Jason Keller's screenplay plagues any possibility of originality, and none of the perfectly capable cast steps above and beyond the call of duty to save this mess. In the end, we're left with something entirely average. The disc looks about as good as a 16mm grain-fest can possibly look in HD and the DTS-HD MA soundtrack is plenty punchy when required, but the extras fail to really tell us anything about the real Sam Childers' on-going plight.
* Note: The images on this page do not represent the Blu-ray image quality.
Review by Gabriel Powers
David Blackwell Senior Member Join Date: February 2004 Location: United States Posts: 2,831
I liked this movie better than you did- it was better than the other film I watched on that day (Safe House which is good for the scenic views, the high color saturation, and Denzel Washington's ability to effectively chew scenery and knock a great performance out yet again).
hogaburger Contributor Join Date: April 2007 Location: United States Posts: 1,153
A bit late here but, Happy 1000th review Gabe!
Under 17 requires accompanying parent or adult guardian
Disc Details
Release Date: 5th June 2012
Discs: 2
Disc Type: Blu-ray Disc
RCE: No
Video: 1080p
Aspect: 2.40:1
Anamorphic: No
Colour: Yes
Audio: DTS-HD Master Audio 5.1 English
Subtitles: English SDH, Spanish
Extras: Machine Gun Preacher: A Discussion with Marc Forster, Making the Music for Machine Gun Preacher, Music Video, Trailers, DVD Copy, Digital Copy
Easter Egg: No
Feature Details
Director: Marc Forster
Cast: Gerard Butler, Michelle Monaghan, Michael Shannon, Kathy Baker, Madeline Carroll
Genre: Action and Drama
Length: 129 minutes
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text:
Assessing Australian Guidelines
Search Medline for
|July 10, 2012
Background: In 2010-11 an international collaboration of guideline development and implementation specialists reviewed 13 draft guidelines for the NHMRC, assessing them against the NHMRC standards for clinical practice guidelines (2007). Several lessons emerged and the findings will be presented and discussed.
Context: NHMRC has a statutory responsibility to approve guidelines in Australia. In 1999 NHMRC began to produce resources to support the development of guidelines by other relevant organisations and agencies. As at October 2011 there are 470+ guidelines on the NHMRC Clinical Guidelines Portal, covering 25 disease groups. Standards (2007) were developed to guide the development of guidelines seeking NHMRC approval. Findings from the initial assessments and feedback from external developers were used to inform a revision of the standards (released in 2011).
Description of best practice: The 2007 standard consisted of 15 domains; each with up to ten criteria covering all aspects of the AGREE tool plus additional measures of importance.
Lessons for guideline developers, adapters, implementers and users: None of the guidelines reviewed initially met all the NHMRC standards. Following production of the 2011 standards and workshops held for developers the following actions were considered:
- Networking opportunities for methodologists and developers to share experience and lessons
- Resources to support the 2011 standard
- Audits of guideline quality.
Quality improvement is a central concept for guideline developers and it is timely to recognise guidelines themselves as quality improvement tools that can be assessed against a structure, process and outcome framework.


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My Mom loves lemon chicken. Any and all kinds of lemon chicken. She makes many different ones including Chicken Francese, Chicken Piccata and this recipe that she just calls Lemon Chicken. It is the simpler of the three – without the strong flavor bursts of the capers in the Piccata or the wine in the Francese. Or the tell-tale pucker. It's a milder, lighter version, and my favorite of the three.
The chicken is lightly dredged in flour and pan-fried. The chicken is removed and garlic and onion are sauteed. The chicken along with lemon juice and chicken broth are added back in to finish cooking in the oven. The lemon and chicken broth together make a flavorful, broth that isn't overpowered by the lemon.
It's nicely balanced, bright, and delicious. The chicken is fork tender and melts in your mouth in little bursts of subtle lemon flavor. This is a perfect summertime comfort meal!
Moon says thanks for all the birthday wishes! He read all your comments:


text:
Sunday was a day of rest and reflection at Wimbledon. So we reflected.
Eyes squinting, brow furrowed, chin resting in palm of hand, we pondered the issue: How good are our tennis players from the United States?
It was a short reflection.
Monday will be a big day here for U.S. tennis, that former juggernaut still funded nicely by the mothership U.S. Tennis Assn., but listing badly to starboard for much of the last decade. Monday, John Isner and Madison Keys play in the second week of Wimbledon.
Ring the cowbells.
Yes, that's all. Two players. Twenty-one from the U.S. started (13 women, eight men) and 19 have departed with congratulatory handshakes at the net — to the other player.
This could have been worse. Both Isner and Keys were scheduled to play Saturday, but rain pushed their third-round matches into the second week. We could have been like an entire country facing Clayton Kershaw. Blanked, shut out, zeroed.
Keys is a promising 19-year-old from Boca Raton, Fla., who has a nice future and lots of seasoned, grizzled seeded players in her path ahead here. Don't expect to spend any Breakfast at Wimbledon time watching her next weekend. That sort of expectation would not be fair.
Isner, well, that's a different story.
He is seeded No. 9 here, is 29 years old, graduated from Georgia before starting his pro career for real, and has the tools to play successfully with the big boys, which he has done on occasion. The best tool is his height. He is 6 feet 10, and trying to return his serve, especially on a grass surface, is like trying to catch a bullet in your teeth.
Sadly, players with names such as Federer, Djokovic, Nadal and Murray have caught the bullet quite well over the years and sent it back easily. Isner has played in 24 Grand Slam tournaments and produced one quarterfinal appearance, at the 2011 U.S. Open.
His Monday opponent is a dangerous 19th seed, Feliciano Lopez of Spain. After that, for Isner to proceed to some weekend Wimbledon action, he would have to wade through, most likely, Stan Wawrinka, then Roger Federer, then Rafael Nadal and finally on to Novak Djokovic or Andy Murray. A total of 40 major titles there.
That's a tall order, even for the tallest of players.
The issue, of course, can't just be strapped to the backs of a 19-year-old newcomer and a 29-year-old underachiever.
It is an issue of national shortfall, in a country that has magnificent resources for a sport that used to offer a buffet of delight from the Pete Sampras-Andre Agassi era, the Jimmy Connors-John McEnroe era, the Arthur Ashe-Stan Smith era, or back to Chris Evert and Martina Navratilova (a naturalized U.S. citizen), Tracy Austin and Pam Shriver, Lindsay Davenport and Jennifer Capriati.
Try as it might, the USTA and U.S. tennis fans cannot live forever in the glow of the Williams sisters and the Bryan brothers, especially since sibling twilight seems to be looming.
This is a complicated problem for U.S. tennis fans, because blaming a fat-and-happy national federation (USTA) for producing mostly fat-and-happy players is a bit simplistic. That's why it was so interesting to see here this week that the Brits, and their equally fat-and-happy leadership (All England Lawn Tennis Assn.), are also under fire.
All Great Britain has left in the Wimbledon draw is Murray. It is not lost on people here that he not only is from Scotland, but got to his current star status in the sport without much aid from the Lawn Tennis Assn.
Like the questions that arise over the apparent ineffectiveness of all that money the USTA is spending on player development, the same questions arise here.
Solutions are complicated and blame comes easily. But there seems to be a common thread on both sides of the Pond. In March, Jose Higueras, No. 2 man in USTA Player Development, fired a shot across the bow when he said, during the Indian Wells tournament, "When a high percentage of the coaches want it more than the players, we have a problem."
This week, no less than Murray's mother Judy, the British Fed Cup captain, told the Guardian newspaper, "Our kids live in a comfort zone. I'd go back to basics and away from the mollycoddling and enormous expenditure. Let's see who really wants it."
Austin and Davenport, both broadcasters here, both in the Tennis Hall of Fame, and representing five major titles, echoed that.
"It's the old fire-in-the-belly thing," Austin said.
Davenport said, "You can't teach a kid to want it."
Clearly, an abundance of players from Eastern Europe want it and probably need it more than our kids and those of our British brethren.
Maybe all this is more generational than organizational. And that's OK, since this isn't about curing cancer or creating world peace.
There will always be great tennis players. Where they come from might merely be a roll of the dice. But Judy Murray is onto something.
Look to future tennis greatness coming from non-mollycoddling countries.


text:
By: Dr Lynda Kelly, Category: At The Museum, Date: 07 Jul 2009
Visitors have made pledges on what they'll do about climate change.
As part of our climate change exhibition visitors completed postcards pledging what they'll do about climate change. A selection have been posted on the climate change page - check them out here.
Some of my favourites include:
Buy clothes from 2nd hand stores instead of new!
Have a worm farm to compost food scraps. Refill a water bottle with tap water.
Make sure the tapes are turned off and not eat meat, and tell the Prime Minister to put signs up saying don't go and kill nature cause we are Australians. And I would stop crime and only buy what I need. (C, aged 6)
Less waste. Live simple.
Use lawn clippings for compost in the garden - don't throw them into the bush.
Use les electricity or else you will be an electricity eater.
What will YOU do?


text:
Richard Le Gallienne
Richard Le Gallienne (1866-1947 / England)
» Click to list general statistics » OR, select a date :
Two Birthdays
Your birthday, sweetheart, is my birthday too,
For, had you not been born,
I who began to live beholding you
Up early as the morn,
read more >>
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text:
�When you�ve finally got other people writing about you, honey, don�t cry, don�t wear no black � because then you�ve got it made!� � Truman Capote
I gave an interview recently to Mark Blankenship of TDF Stages: A Theatre Magazine. Here�s what happened and what Mr. B wrote:
The gossip queen is a unique expert on the Broadway season. If you�re looking for an expert on this spring�s Broadway plays, then start with Liz Smith. Not because she wrote the scripts or designed the costumes, but because she knew the people the plays are about and because she�s probably having cocktails with the actresses who play them.
Smith is an institution of celebrity reporting and gossip. With almost 60 years� experience � including her current work at The Huffington Post, NewYorkSocialDiary.com, and Wowowow.com � she�s gotten to know almost everyone there is to know. That gives her a unique perspective on two Broadway plays: �Ann,� which was written by and stars Holland Taylor as former Texas governor Ann Richards, and �I�ll Eat You Last,� which stars Bette Midler as legendary Hollywood agent Sue Mengers. Smith was close with Richards, knew Mengers, and is friends with both Taylor and Midler.
In other words, she can answer questions that plenty of other people can�t.
For instance, how might Richards have felt about her life being turned into a play? �I think she would have enjoyed it, but I think she would have thought Holland was totally insane,� Smith says. �Because Holland knows more about Ann than anybody in the world now.�
It�s easy to see why Richards � who shot to fame after her fiery speech at the 1988 Democratic National Convention and went on to spend a term as Texas governor � would make for good theater. �She was so energetic!� Smith recalls. �(Her boyfriend) and I would go with Ann to the theatre, and she would leave us! We�d be back at the light, creeping along like we were 85, and Ann would be two blocks ahead.�
Her wit matched her energy. Smith, who is also from Texas, recalls being invited to speak on a panel for comic women in the 1980s. Richards, who was then the Texas state treasurer, was also there, and Smith says, �She was the person who was funny. The rest of us were supposed to be funny, but we weren�t funny at all.�


text:
What Is a FODMAP Diet?
Dr. Sharon Orrange -
A low FODMAP diet equals a happy gut for some. FODMAPs are carbohydrates (sugars) found in food. FODMAPs are substances that cause problems in two ways: they aren't absorbed well so they tend to suck water in to the gut and they stick around longer so they are fermented by bacteria. The result is gas, bloating, cramping, and diarrhea in some people.
A diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) has been recommended in patients with irritable bowel syndrome (IBS). See More


text:
SOUTH HADLEY, Mass. – MIT head women's openweight crew coach, Holly Metcalf, was honored today when Mount Holyoke College announced that she will be a member of the inaugural induction class into the Mount Holyoke Athletics Hall of Fame. Metcalf will be inducted along with six other individuals and one team in ceremonies scheduled for October 19.
Metcalf was a six-time member of the U.S. National Rowing Team and won five World Championship and Olympic medals. At the 1984 Olympics, she captured the Gold Medal in the women's eight. Metcalf has coached extensively at the club, college, and national team levels, including at Mount Holyoke. Metcalf has earned a number of accolades over her career, including two USRowing Woman of the Year honors, as well as induction into the New England Women's Sports Hall of Fame and the USRowing Hall of Fame.
The 2013-14 season will be Metcalf's seventh as head coach at MIT. She has transformed the program into a Division I squad into a team that is competitive within the Eastern Sprints, as well as its new conference, the Patriot League. Additionally, in every year under Metcalf the team has earned Public Recognition Awards from the NCAA for its exceptional academic performance.


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Monday, October 22, 2012
12 Crucifixion and Reform
12 comments:
When phat & Tygarth talk of a Truth & Recon. Comm. very few want to listen , but when John Fahey of WADA inaugerates the " AMNESTY for ALL SPORTS " , let us ALL hope , that Athletes both , past & present , take the opportunity to clear their misdeeds !ReplyDelete
Sport is just about controlled by the Criminal Elements and this is the only way Any Athlete can get out from Under !
When Sport is once again CLEAN , then the future generations will be able to INSPIRE rather than entertain !
We should never forget the Dark Ages of Armstrong. If we do, then we're bound to make the same mistakes, and will it only be a matter of time before another Lance takes the sport into another Dark Age.ReplyDelete
It's clear the sport needs restructuring. The idea of UCI both promoting the sport and being responsible for anti-doping has proven to be fatally flawed. Anti-doping should be the responsibility of an independent body, and WADA and the national ADAs naturally comes to one's mind. WADA for the pro teams, the national ADAs for the amateurs.
There also needs to be another look at globalization, and how it's currently shaped. Do we really care for the Tour of Langkawi, Oman, or Beijing? I think it would be far better to support the local cycling communities in those countries, and help them work their way up with their events to a continental status. I'd much rather have the Tour of Bourkina Faso included in the ProTour than the Tour of Oman, as the former has proved itself over time.
Thirdly, there needs to be transparency. At the moment, who gets to be in the ProTour is at the whims of UCI. For instance, there is no guarantee that any party who is interested in the Rabo team will get to be licensed, even then they pass every rule and regulation.
And there's way too much emphasis on men road racing. Apart from the obvious that women also race, there are other disciplines in cycling that so far have fallen by the way side. that's not only unfair to those athletes, but it also promotes tunnel vision.
- Anonymous8:54 PM
The Armstrong era is downright ugly and scary. If I think about him , essentially it is one wondering when he'll offer a public apology to his fans and to the athletes he forced into doping. It will truly be beyond disgusting to sit on and be quiet in hiding. That is the true nature of a coward who can't own up to his mistakes.ReplyDelete
Larry says: As Greg LeMond has said, cycling has a great opportunity here, even better than the last big one - The Festina fiasco. An opportunity to clean things up. Sadly, the bike industry, by continuing their support for the charity set up by the cheater is not helping, nor is the UCI, blaming the whole deal on, well, ANYBODY who is not the UCI. I fear the same response as in the Festina mess..."The wicked witch is dead folks, nothing to see here, move along, we'll take care of everything and make it all right again." while it's business and corruption as usual for the teams, crooked docs, dope suppliers, etc. that plague the sport.ReplyDelete
I really don't have to much more to write on him. I think all of us must just stop talking about Lance, think of it like a bad dream that never happened.ReplyDelete
psychology thesis writing
Cozy - Apologies after the fact but i used your wonderful image in my post at The Northern Myth today. No credit other than the watermark ... but happy to amend if necessary. The unfortunate side-effect was when a friend said that the pic reminded them of me as a feckless, pockmarked youth ...ReplyDelete
And again, thanks. Bob
Post here: http://blogs.crikey.com.au/northern/2013/01/17/ten-australian-questions-for-the-cancer-jesus/
I really trusted that guy...ReplyDelete