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Schilthuis family
Schilthuis, a Mennonite family found at Groningen, Netherlands, since the early 18th century, where they were grain merchants. According to a family tradition Uko Walles was one of its ancestors. One of the most outstanding members of this family was Ulferdus Gerardus Schilthuis (1799-1856), a grain dealer at Groningen. He was a member of the Provincial States of Groningen and from 1837 a justice of the peace at Groningen. He was the promoter of new branches of trade and agriculture in the province of Groningen, and through his initiative a school of agriculture (Landhuishoudschool) was founded at Groningen. He married Coenradine Catherina van Delden (1797-1871). At present a branch of this family is also found at Rotterdam; Ulferdus Gerardus Schilthuis, a lawyer at Rotterdam, was a member of the church board of the Rotterdam congregation.
|Nanne van der Zijpp
|Date Published
Cite This Article
MLA style
Zijpp, Nanne van der. "Schilthuis family." Global Anabaptist Mennonite Encyclopedia Online. 1959. Web. 17 Nov 2018. http://gameo.org/index.php?title=Schilthuis_family&oldid=77511.
APA style
Zijpp, Nanne van der. (1959). Schilthuis family. Global Anabaptist Mennonite Encyclopedia Online. Retrieved 17 November 2018, from http://gameo.org/index.php?title=Schilthuis_family&oldid=77511.
Adapted by permission of Herald Press, Harrisonburg, Virginia, from Mennonite Encyclopedia, Vol. 4, p. 456. All rights reserved.
©1996-2018 by the Global Anabaptist Mennonite Encyclopedia Online. All rights reserved.


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South Korea cracks down on draft-dodger advice sites
Robots can't do it all, say generals
The South Korean defence ministry has cracked down on web-assisted draft dodging, according to reports. The country's military depends heavily on conscript manpower, but service is unpopular and there are various loopholes through which young men can avoid it.
According to an AFP report yesterday, South Korean defence officials have contacted hosting companies and insisted that offending sites be taken down.
"We have sent official letters to major internet portals such as Daum and Naver to ask for the closure of those illicit websites," said ministry spokesman Kim Hyung-Gi.
All able-bodied South Korean men are theoretically liable for a two-year hitch, which helps to keep the republic's armed forces manpower at around 680,000. There are also more than 29,000 American troops stationed in South Korea to help the southerners garrison the Demilitarised Zone separating them from the totalitarian north.
North Korea is perhaps the most powerful of the so-called "rogue states", with armed forces over a million strong and an arsenal of ballistic missiles. These last might soon threaten even the continental USA, and the north is also thought to be developing usable nuclear weapons.
Despite this fairly serious threat, South Koreans normally prefer that somebody else guard the walls, and draft dodging is reportedly endemic. There is an exemption for those who work for 34 months or more at companies nominated by the government as being economically critical, and this is widely abused. AFP says "sons of the rich and powerful" bribe their way into the listed firms.
Even if the South Koreans can arrest the tendency to bunk off time in uniform, demographic trends indicate falling military manpower in future. More automation efforts, such as the Samsung SGR-A1 automated gun-bot, may be deployed in future. ®

subset: commoncrawl


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Warren Wiersbe's Old Testament "Be" Series (27 vols.) by Warren W. Wiersbe
This product features all of Warren Wiersbe's "Be" Series of Old Testament commentaries. Breaking down each book into topical chapters, Wiersbe writes an approachable commentary series that allows any reader to understand the biblical text in new ways. The "Be" Series is the culmination … more


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Secretary of State Todd Rokita Introduces HAVA Team
Contact: Heather Sewell
Team organized to develop statewide elections plan
Indianapolis, IN - Indiana Secretary of State Rokita today convened his 28-person team to help develop a statewide plan for implementation of the Help America Vote Act of 2002 (HAVA). The group, which is composed of a diverse group representing many voting communities, will work to formulate a comprehensive plan to make Indiana elections compliant with the federal act and to bring over $80 million to Indiana if Congress fully funds the Act. The plan will include the following: updated voting machines, compilation of a statewide voter file, better accessibility of polling places for the disabled, and educational training for both poll workers and voters, and other election administration issues.
"This is the most sweeping change in election law since the Civil Rights Act of 1964," stated Secretary Rokita.
The bi-partisan group, made up of community leaders, election division representatives, and state elected officials, will meet on a weekly basis and will be facilitated by Sarah Taylor. The team will have the state plan completed by July 1.
In addition to developing and leading this team, Secretary Rokita has been making personal contact with federal legislators to garner their support on funding for election reform and administration. Rokita recently attended a HAVA conference where he worked with leaders across the country to address the changes HAVA brings.
"This is one of the most critical roles I have as Secretary of State. As the Chief Elections Officer, it is my job to protect the sanctity of the vote by making our elections as accessible and accountable as humanly possible," stated Rokita.


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MGC Diagnostics Corporation Appoints Wesley W. Winnekins as Executive Vice President, Finance and Corporate Development; Winnekins will also serve as Chief Financial Officer
Feb 04, 2013, 08:00 ET
SAINT PAUL, Minn., Feb. 4, 2013 /PRNewswire/ -- MGC Diagnostics Corporation (NASDAQ: MGCD) (formerly Angeion Corporation), a global medical technology company, today announced the appointment of Wesley W. Winnekins as Executive Vice President, Finance and Corporate Development, effective immediately. Mr. Winnekins will also serve as the Company's Chief Financial Officer.
(Logo: http://photos.prnewswire.com/prnh/20120821/LA60189LOGO)
In connection with the appointment of Mr. Winnekins, the Company will be entering into a Separation Agreement with the prior Chief Financial Officer Robert M. Wolf. Mr. Wolf's last day as Chief Financial Officer was January 31, 2013.
Prior to joining MGC Diagnostics, Mr. Winnekins served as Chief Financial Officer of Snap Fitness, Inc. a multi-national franchisor of 24/7 express fitness clubs from February 2011 to October 2012. Prior to that, he was employed by Health Fitness Corporation from February 2001 to December 2010, serving as Executive Vice President, Finance and Operations from March 2010 to December 2010, and as Chief Financial Officer and Treasurer from February 2001 to February 2010. Prior to working at Health Fitness Corporation, Mr. Winnekins served in finance and management capacities for several public and private companies, including health and fitness companies, from October 1987 to February 2001. From May 1985 to October 1987, Mr. Winnekins served in the audit practice at Arthur Andersen. Mr. Winnekins received a Bachelor's in Business Administration with a major in Accounting from Iowa State University and has passed the CPA exam.
Gregg O. Lehman, Ph.D., president and chief executive officer of MGC Diagnostics, said, "I am pleased to have Wes Winnekins join our management team. He is a proven public company financial executive with a broad skill set that includes SEC financial reporting, mergers and acquisitions, and a highly developed network of professionals that spans a career of more than 25 years. These credentials will make Wes an invaluable partner as we continue to execute our strategic plan."
"I want to express my appreciation to Rob Wolf who has left the Company to pursue other opportunities," continued Dr. Lehman. "Rob has been a valuable member of our leadership team and has provided stability and solid performance during his tenure as CFO. I am grateful for his contributions and wish him the best in the future."
About MGC Diagnostics
MGC Diagnostics Corporation (NASDAQ: MGCD), (formerly Angeion Corporation), is a global medical technology company dedicated to cardiorespiratory health solutions. MGC Diagnostics develops, manufactures and markets non-invasive diagnostic systems. This portfolio of products provide solutions for disease detection, integrated care, and wellness across the spectrum of cardiorespiratory healthcare. The Company's products are sold internationally through distributors and in the United States through a direct sales force targeting heart and lung specialists located in hospitals, university-based medical centers, medical clinics, physicians' offices, pharmaceutical companies, medical device manufacturers, and clinical research organizations (CROs). For more information about MGC Diagnostics, visit www.mgcdiagnostics.com.
Cautionary Statement Regarding Forward Looking Statements
From time to time, in reports filed with the Securities and Exchange Commission, in press releases, and in other communications to shareholders or the investing public, MGC Diagnostics Corporation may make forward−looking statements concerning possible or anticipated future financial performance, business activities or plans that include the words "believes," "expects," "anticipates," "intends" or similar expressions. For these forward−looking statements, the Company claims the protection of the safe harbor for forward−looking statements contained in federal securities laws. These forward−looking statements are subject to a number of factors, risks and uncertainties, including those disclosed in our periodic filings with the SEC, that could cause actual performance, activities or plans after the date the statements are made to differ significantly from those indicated in the forward−looking statements. For a list of these factors¸ see the sections entitled "Risk Factors" and "Cautionary Note Regarding Forward Looking Statements," in the Company's Form 10-K for the year ended October 31, 2012, and any updates in subsequent filings on Form 10-Q or Form 8-K under the Securities Exchange Act of 1934.
Gregg O. Lehman, Ph.D.
Joe Dorame, Robert Blum, Joe Diaz
MGC Diagnostics Corporation
Lytham Partners, LLC
Chief Executive Officer
(602) 889-9700
(651) 484-4874
SOURCE MGC Diagnostics Corporation


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Official Netflix app arrives in the Android Market
Hallelujah! The official Netflix app for Android just popped up on the Android Market. Before you go rushing off to download the app, there's something we need to tell you first. The app is only available for the following devices:
HTC Incredible with Android 2.2 HTC Nexus One with Android 2.2, 2.3 HTC ... Read More »


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Active duty military patriots are grounded for the 2013 Miramar Air Show. Instead, civilian ones will headline the annual air fest this fall, the Marine Corps said Monday, releasing its confirmed lineup of performances.
The Patriots Jet Team of volunteer civilian pilots will fly the San Diego skies Oct. 4 and 5 in their L-39 jets, serving as main attraction for this year's truncated, two-day event. Other civilians booked for the air show include Sean Tucker in his high-performance biplane Oracle Challenger, Chuck Aaron in the Red Bull Helo and John Collver in his AT-6 War Dog, a World War II-era fighter plane trainer.
Ground-level attractions include the Shockwave Jet Truck, which races at more than 300 mph against airplanes. The Twilight Show on Saturday will conclude with "a spectacular fireworks demonstration" and the "Great Wall of Fire," said 1st. Lt. Chad Hill, a Miramar spokesman.
The Marine Corps will show off a large number of active and vintage military aircraft and ground combat equipment parked on the flight line. But military air crews are prohibited from flying in air shows this year, because of a Defense Department policy in the wake of sequestration budget cuts.
More than 30 of the 56 air shows nationwide scheduled to feature the Navy Blue Angels or Air Force Thunderbirds flight demonstration teams were canceled this year because of the lack of military participation, according to the International Council of Air Shows, a trade group.
The 3rd Marine Aircraft Wing headquartered at Miramar considered whether to scuttle its event after the Pentagon denied its request to proceed with local military units flying. The Marines hoped to be granted a waiver because, among other reasons, the normally three-day event makes an average net profit of $1.5 million annually, not including military aircraft operations costs paid for by training funds.
Those profits fund community programs on base supporting Marines and their families.
The 2013 Miramar Air Show will go on, the Marines announced. But it will be shorter and many would say less exciting because of the lack of military flights.
"It's that way across the country. It will be a different experience for the spectators but it will not be any different for us as a team. We brief and fly our demonstration regardless of who else participates," Patriots lead pilot Dean "Wilbur" Wright told U-T San Diego last week.
Wright is a retired Air Force lieutenant colonel who flew as a solo fighter jet pilot in the service's Thunderbirds demonstration team. The Patriots team also includes pilots who flew with the Navy Blue Angels and Canadian Snowbirds before returning to civilian life.
The Patriots impressed the crowds at last year's Miramar Air Show with precision six-jet aerobatics and the Tail Slide, when the aircraft slides backward toward the ground. But the stars of the show were the military acts, including the Blue Angels, an F-22 Raptor, and the drama and explosions of the Marine Air Ground Task Force demonstration.
Will civilian acts be enough of a draw for what has been in previous years the nation's largest military air show? According to an online poll by U-T San Diego, maybe not. Among 175 voters, 72 percent said they would not attend the Miramar Air Show if military aircraft aren't flying.
Col. John Farnam, commanding officer of the Marine installation, asked San Diegans to attend anyway. He promised to give families a time to remember despite this year's constraints, and a chance to meet the Corps' most valuable asset, its Marines.
"They are who I need you to see and understand," Farnam said. The base open house "will give you an opportunity to understand your Marine Corps and what it is that we do for the nation. To see that your trust in us, to protect our way of life, to protect our nation, is not misplaced."
The complete list of aerial performers is posted here.


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When I was a newlywed, a door-to-door salesman for Cutco knives was transversing my neighborhood. Some of my sister-in-laws, convinced of their merits, succumbed and made the investment. Me? I didn't want any sharp knives in my house. I was too scared.
can you recommend any specific chopping knives, honing thingies and sharpeners? I have some knives i've bought in the past that really did not last.


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Hamburg is located in Ashley County, about 125 miles from Little Rock. In 2011 it was designated a Preserve America Community. The town was created in 1849, two months after Ashley County was formed from part of Drew County. Two of the first public buildings were built the next year, the courthouse and the county jail.
During the Civil War, the town provided troops to the Confederacy and several companies of the Third Arkansas Infantry that fought with the Army of Northern Virginia, commanded by Hamburg lawyer Van H. Manning. The town escaped military action during the war, though Union troops briefly occupied it during Reconstruction.
The city's economy was divided among agriculture and forestry due to the town's geographic location. Immediately east and west are prairie regions dedicated to rice and soybean culture. A few miles east, cotton reigns in the Mississippi Delta. On the north and the south, timber is plentiful. Through the early 1900s, agriculture dominated though lumber production became important in later years. After the Depression, social shifts occurred when farmers gave up attempts to live off their land. Many left the region or went to work in sawmills or paper mills. The town grew up around the railroad, which enabled the country's agriculture and timber industries to flourish until the automobile became the major mode of transportation in the 1920s. After World War II, pressures on small farmers led to the arrival of agricultural enterprises. Eventually the tone of the industry changed and small family farms were replaced by larger agricultural units.
These days, the downtown square, with its gazebo, now serves as home-base to the annual Armadillo Festival, held the first weekend in May since 1970. Though many of the historic buildings have disappeared, the town has several structures on the National Register of Historic Places. Among them are the Watson House, now the Ashley County Museum, built in 1918; the Watson-Sawyer House, built in 1870; and the W. R. Bunkley House, built in 1903.
Among Hamburg's famous former residents are Colonel Van H. Manning, who helped organize and command the Third Arkansas Infantry, writer Charles Portis, author of such novels as True Grit, and former NBA star Scottie Pippen. Pippen Meadows Golf Course, the town's first golf course (9 holes), opened in 2008 and is owned by Pippen.


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|Publisher name
|Long name
|Hewson Consultants Ltd / Hewson Associates
|Birth year
|Year of death
|Mother country
|United Kingdom
Formed in 1983 by Andrew Hewson, the company established itself as one of Europe's most successful 8-bit game publishers of the 1980s with classic hits such as PARADROID, QUAZATRON and URIDIUM. Much of this success can be attributed to Hewson owning his own cassette duplication facility, thus being able to respond to market trends much more quickly than most publishers who relied on larger companies to duplicate their software in set volumes. This allowed Hewson to produce low volume original product and thus support many independent developers which produced most of Hewson's games out-of-house.
Andrew Hewson proved quite adept at discovering unknown, talented developers (e.g Andrew Braybrook/Steve Turner aka Graftgold, Raffaele Cecco, John Phillips) and forged good working relationships with them. They developed the games and he marketed them, which allowed them a great deal of creative freedom that often paid handsome dividends in the playability of games produced. This worked well until the late 1980s when the games industry shed its cottage industry grassroots and became more commercialised. Consequently, the cost of developing games rose exponentially and developers required large cash advances from publishers to maximise the chances of games being completed and published. This spelt disaster for a lot of small independent publishers at the time and Hewson would be no exception in the longer term.
In 1987/88, Hewson entered the 16-bit market and converted two of their 8-bit smash hits, RANARAMA (Atari ST) and ZYNAPS (Amiga, Atari ST). Unfortunately, many of their early 8-bit ports didn't exploit the much-advanced 16-bit features of the Amiga and Atari ST, which translated into poor sales. Combined with diminishing returns from their budget Rack-It label in an increasingly saturated budget games market, Hewson ran into financial trouble in the late 1980s. This prompted a mass exodus from Hewson, which included its second in command (Debbie Silletoe to Telecomsoft), two in-house programmers (John Cumming and Dominic Robinson to Graftgold) and its most successful out-of-house development team in Graftgold (to Telecomsoft also). The loss of Graftgold was probably the most damaging given their phenomenal success with Hewson. However, Andrew Hewson only had himself to blame, having offered Graftgold neither a contract nor any cash advances to remain committed to the company. Hewson somehow managed to survive and legally challenged Telecomsoft's right to publish the two games (MAGNETRON, RAINBOW ISLANDS) that Graftgold had been developing before jumping ship. A court case followed, which delayed publication of the games and prompted Telecomsoft and Graftgold to settle out-of-court.
Unfortunately, few lessons were learnt in the late 80s transition to 16-bit machines. Hewson continued to churn out unremarkable 16-bit conversions of their 8-bit games, albeit charging Amiga and Atari ST owners full price for those that were only considered good enough for budget release originally on their 8-bit counterparts. In 1991, Hewson Associates closed its doors and was quickly succeeded by 21st Century Entertainment, with Andrew Hewson being one of its founding members.
|Also known as
21st Century
|Publisher logo
|This publisher page has been viewed : 389437 times
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|Coded by RCK of abime.net - Content © 1998-2018 HOL TEAM - Online amiga database © 2002-2018 HOL TEAM - Gen. in 0.06s


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Pebble is by far one of the most successful crowd financed projects. If you haven't heard of Pebble already (unlikely), it's a smartwatch that's infinitely customizable. You can connect it to an iPhone or Android using Bluetooth to sync calendars, alerts, emails, even incoming calls. Within hours of going live, the project broke its $100,000 funding goal. Then it kept going, and going, and going until it reached over $10 million dollars in financing! On their website, Pebble is pre-selling their watches for $150US.
Panda sunglasses are like TOMS Shoes but for your face. They are ecofriendly sunglasses handcrafted from sustainable bamboo, and for every pair you purchase, Panda will provide an eye exam and a pair of prescription glasses to someone in need. Vincent Ko, the founder, decided to post his idea for Panda sunglasses to Kickstarter in late 2011 with a $3,000 goal. He surpassed his goal by over 600%. The funds allowed Ko to start production with a woodworking shop in China. You can buy Panda glasses for $120US which includes free shipping and a lifetime warranty.
Eddie Tsai used crowd funding websites to validate the demand for a moustache tie clip before investing money. Tsaiclips are forged from solid brass and coated in chrome steel or gunmetal, and they sell for $35US.
Ramos Alarm Clock was founded by a group of young engineers outside of NYC. It's an alarm clock that is beautifully constructed with four glowing nixie tubes that display the time in a very unique way. The clock also comes with a wireless alarm deactivation panel that will get you out of bed to turn off the buzzer. In February 2012, they launched their project on the crowdfunding website Kickstarter where they received over 400 orders in a month and a half. Ramos clocks range from $200 - $800 and they're currently up for pre-sale. Expected delivery: September 2012.
Dave Jackson and Dave Petrillo are two mechanical engineers from New Jersey. They developed polished stainless steel beans that regulate the temperature of coffee and called them Coffee Joulies. Their product is an amazing crowd funding success story. They've been covered by Gizmodo, Mashable, WIRED, and Popular Science. Coffee Joulies also won our Build-A-Business Competition grand prize of $100,000 cash plus VIP trips to meet Tim Ferriss, Gary Vaynerchuk, and Seth Godin. You can buy a 5-pack of Coffee Joulies for $49.95US.


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The Cappadocian Fathers, as they later came to be known, were brothers Basil and Gregory and Gregory Nazianzen, all from Cappadocia, a region in central Turkey. Recognized for their monastic leadership, they were also astute theologians. The term Cappadocians, however, is more fitting than Cappadocian Fathers because it captures three generations of a family, both women and men. The grandmother of Basil and Gregory was Macrina the Elder, who fled persecution only to be left widowed and impoverished. Yet she ministered to those who were even more needy and was canonized as the patron saint of widows.
One of Macrina's sons was Basil (the elder), who had nine children, five of whom were designated as saints. Macrina (the younger) (324 - 379), named for her grandmother, was the older sister who had a profound influence on her siblings as well as on her mother.
Macrina the Younger had chosen a life of asceticism after her fiancé died, and she treated her servants as sisters and equals. She later joined with Basil to form a convent in conjunction with his monastery. The most celebrated of the Cappadocians, he is recognized as Basil the Great (329 - 379), Father of Eastern Monasticism. Setting aside worldly aspirations and touring monasteries in Egypt, Basil returned to Cappadocia, where he established a monastery. His "Longer Rules" and "Shorter Rules" are still used today, and all monks in the Eastern church are Basilian monks. Basil viewed monastic life as one of service to those in need, setting the example by selling his family's estate for famine relief and calling on other wealthy landholders to do likewise. He worked in the kitchen and dispersed provisions alongside ordinary monks, distributing food freely to any in need, regardless of ethnicity.
Basil had a flare for words and is remembered particularly for "The Six Days," his series of nine sermons on creation that display the beauty of God's natural wonders. In 370 he was named bishop of Caesarea, pitting him against Emperor Valens, an Arian. When he died in 379, the entire population of Caesarea—Christians, Jews, and pagans—is said to have followed his funeral cortege with weeping.
Basil's younger brother Gregory of Nyssa (335 - 394) did not enter the monastery and may have been married to Theosebia, a much-heralded deaconess in the church at Nyssa, where Gregory served as bishop. His writing set the stage for the Eastern church's focus on apophatic theology, which emphasizes that God is ultimately unknowable. While strongly defending the doctrine of the Trinity, he insisted that God is infinite and transcendent and thus beyond our understanding. The true way to God is through darkness.
Gregory Nazianzen (c. 325—389), the third of the Cappadocian Fathers, was a close associate and friend of Basil and Gregory of Nyssa. His mother was instrumental in converting her husband, Gregory, who subsequently became bishop of Nazianzus. Young Gregory accused his father of tyranny and left home, only to later return and work with his father in the church.
Gregory later gave away his wealth and entered a monastery. On his own deathbed, Basil, not a man to hold grudges, recommended his friend Gregory to a post as the leading theologian in Constantinople with the hope that he would defeat Arianism. As such, Gregory's tenure in Constantinople was anything but peaceful. The city was deeply divided, but he began drawing crowds with his powerful preaching. His "Five Theological Orations," defending the Trinity and the deity of Christ, were aimed at Arians.
Arian opponents stormed his church in 379 during the Easter vigil, killing one bishop and wounding Gregory. Matters improved when Theodosius ascended the throne and vowed to rid the East of Arians once and for all. Gregory was elected bishop of Constantinople to replace the Arian bishop dismissed by the emperor, but his problems were far from over. Accused of attaining his position illegally, he resigned: "Let me be as the Prophet Jonah! I was responsible for the storm. . . . Seize me and throw me." The emperor accepted his resignation, and Gregory returned to Cappadocia where his ministry began.
Today's reading is from Parade of Faith: A Biographical History of the Christian Church by Ruth Tucker. © 2010 by Zondervan. Used with permission. All rights reserved. The book's title must be included when sharing the above content on social media.


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What is the Advisory Council?
Each Institute of the National Institutes of Health maintains a national advisory council which has two general functions: (1) to advise the Institute on policy and procedures affecting the extramural research programs and (2) to provide a second level of review for all grant and cooperative agreement applications considered by the Institute for funding. Except for fellowships, the NINDS may not award a grant unless it has been recommended for support by the National Advisory Neurological Disorders and Stroke (NANDS) Council.
The NANDS Council meets regularly three times a year: in early February, late May, and mid-September. Each meeting of the NANDS Council is about one and one half days long. A portion of this meeting is open to the public and the remainder is a closed confidential session devoted primarily to the review of applications.
In addition to application review, the NINDS Director utilizes the expertise and experience of NANDS Council members for activities such as the following:
NANDSC Membership Roster
Laurence F. Abbott, Ph.D. (2020)
William Bloor Professor of Theoretical Neuroscience, Department of Neuroscience and Department of Physiology and Cellular Biophysics
Columbia University, College of Physicians and Surgeons
Issam A. Awad, M.D. (2020)
John Harper Seeley Professor of Surgery, University of Chicago;
Director of Neurovascular Surgery, University of Chicago Hospitals
Christopher T. Bever, Jr., M.D.
Ex Officio Member, Associate Chief of Staff for Research and Development
Staff Neurologist
Department of Veterans Affairs
Hollis T. Cline, Ph.D. (2021)
Chairman, Department of Neuroscience and the Hahn Professor of Neuroscience
Departments of Molecular and Cellular Neuroscience
The Scripps Research Institute, La Jolla, California
Susan Lloyd-Jones Dickinson (2021)
Executive Director
The Association for Frontotemporal Degeneration
Radnor, Pennsylvania
Gordon J. Fishell, Ph.D. (2019)
Professor of Neurobiology
Harvard Medical School and the Stanley Center at the Broad Institute
David H. Gutmann, M.D., Ph.D. (2019)
Donald O. Schnuck Family Professor, Department of Neurology
Washington University School of Medicine
David B. Hackney, M.D. (2021)
Professor in the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston
Assistant Dean for Faculty Development and Professor of Radiology at Harvard Medical School
Janet Hieshetter (2019)
Executive Director
Dystonia Medical Research Foundation
Colonel Sidney R. Hinds, M.D.
Ex Officio Member, Brain Health Research Program Coordinator,
DoD Blast Injury Research Program Coordinating Office and Medical Advisor to the Principle Assistant for Research and Technology
Medical Research and Materiel Command
Karen C. Johnston, M.D. (2021)
Professor of Neurology and Public Health Sciences and Chair of the Department of Neurology
University of Virginia
Bruce Ovbiagele, M.D. (2019)
Admiral Paul E. Pihl Endowed Professor of Neurosciences
Medical University of South Carolina
Steve Perrin, Ph.D. (2019)
Chief Executive Officer, Chief Scientific Officer, President and Vice Chairman
Amyotrophic Lateral Sclerosis Therapy Development Institute
Indira M. Raman, Ph.D. (2020)
Bill and Gayle Cook Professor of Biological Sciences
Department of Neurobiology, Northwestern University
Steven L. Roberds, Ph.D. (2020)
Chief Scientific Officer
Tuberous Sclerosis Alliance
|Meeting Dates
|September 12-13, 2018
|NIH, Building 31, C Wing, 6th Floor, Conference Room 6
|February 14-15, 2019
|NIH, Building 35, Porter Building, Conference Room 620/630
|May 23-24, 2019
|NIH, Building 45, Natcher Conference Center, Conference Room E1/E2
|September 4-5, 2019
|NIH, Building 35, Porter Building, Conference Room 620/630
Meeting Agendas
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Minutes of Recent Meetings
May 24, 2018
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Council Operating Procedures
The National Advisory Neurological Disorders and Stroke Council (NANDSC) advises the Director of the National Institute of Neurological Disorders and Stroke (NINDS) on research activities and policies. The NANDSC provides the final review for all applications for research grants, training grants, and career development awards assigned to the NINDS, as well as for other requests for support for which Council approval is required by law. The NANDSC also provides clearance for concepts for new NINDS research initiatives involving set-aside funds.
At the January/February Council meeting each year, Council reviews these Operating Procedures NINDS and, where appropriate, makes recommendations for revision.
The operating procedures document the circumstances in which the institute and the national advisory council have agreed it is desirable to discuss individual applications. Some of the more common circumstances are:
The national advisory council may vote en bloc concurrence with the recommendations of the IRGs for the applications for which no review or policy issues have been identified.
A national advisory council may vote to recommend that the institute consider paying certain applications out of scientific merit priority score order. These applications are designated as having High Program Priority (HPP). Similarly, in cases of high scientific merit but Low Program Priority (LPP), the national advisory council may vote to recommend that institute staff consider not funding specific applications. This latter procedure is rarely used in NINDS. While these various recommendations by council are considered seriously by the institute, the final legal authority for payment of grant applications rests with the NINDS Director.
In addition to application review, the NINDS Director may utilize the expertise and experience of Council members for the following activities.
Staff may request expedited electronic review of specific applications. All Council members will be asked to participate in the expedited review and will be notified of the applications under consideration. Expedited electronic review may be designated for, but not limited to:
NINDS has adopted the Early Concurrence Process as one means of shortening the time between application receipt and award. The main purpose of the early concurrence process is to focus Council attention at the actual Council meeting on those applications that truly require active Council consideration. Another important purpose of this process is to allow earlier funding of grants. Three members of the NANDS Council are selected by the Council Executive Secretary and asked to act on behalf of the full Council to implement early en bloc concurrence with initial review group recommendations for each Council round (approximately eight weeks before each Council meeting) for eligible applications within the payline. All Council members are welcome to participate in the voting. The members vote using the Early Concurrence Voting Module of the NIH Electronic Council Book. If there any applications that any Council members wish to designate for discussion, these are noted and brought up at the Council meeting. Results of this process are discussed at each Council meeting.
In open session, the Council conducts concept review of potential research initiatives that either require set-aside funds, or are of particular importance. These initiatives are proposed by NINDS staff and originate from consultation with the scientific community, constituency organizations, and Congress. Council may recommend approval, modification, deferral, or disapproval of a concept. NINDS staff will record and maintain documentation reflecting Council discussion and recommendations.
At the January/February Council meeting, the Director of the Division of Intramural Research provides an update on the intramural research program and the recommendations of the previous year's Board of Scientific Counselors reports.
The Institute staff may take the actions listed below without Council review. Council may request information on these actions at any time.
In the closed portion of the meeting, all research grants and cooperative agreements must undergo Council review and approval prior to being awarded. Based on budgetary information available, staff provides the NANDSC with a projected "payline" for research project grant mechanisms, (e.g. the R01, R03, R21, and R15). This procedure assumes that all applications within a given percentile rank will be paid regardless of program relevance. The payline is projected, however, to leave additional funds for the payment of special initiatives including selected applications outside the payline. These applications are selected on the basis of program relevance or related reasons, and are known as "high program priority" applications. Please note that although it is NIH policy to use the percentile rank rather than the priority score in determining the payline, both of these numbers (priority scores between 10 and 90 and percentiles from 1.0 and above in whole numbers) are printed on summary statements and computer-generated percentile lists supplied to the NANDSC. (Some types of applications, such as Institutional Training Grants and applications in response to an RFA are not 'percentiled.' Such applications are not interdigitated with applications that are percentiled.)
Approximately two weeks before NANDSC meets, the staff of each program selects applications that it believes are worthy of the HPP designation. Lists of such recommendations are made available to the NANDSC in advance of the meeting so that staff may ask Council's advice regarding potential payment of these applications. NANDSC members can also nominate, prior to the Council meeting, applications to be discussed for consideration. At the Council meeting, both staff and Council-nominated applications can be discussed. Council feedback concerning these applications is critical to the decision-making process of NINDS staff. It must be recognized, however, that the budgetary situation may change after the NANDS Council meeting and that more applications are nominated for HPP consideration than can be awarded. Staff may also make awards beyond the payline on applications that had not been identified for high program priority if budgetary balances should be unexpectedly large; this situation, however, is quite rare.
The following options are available to Council for all applications under review:
Applications that raise no special issues need not be discussed individually. On these, Council may vote en bloc concurrence with the recommendations of the study section.


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Summary of Comments
| Opening Remarks | Presentation | Discussion |
On March 11, 1997, the Department of Education convened a meeting with approximately 20 members of the postsecondary education community to discuss proposed rules for financial responsibility. This meeting was a follow-up from the meeting on February 5, 1997, and included many of the same representatives from institutions and postsecondary associations. The meeting was organized to provide a progress update since the last meeting and to continue to discuss issues that have been raised in previous meetings and through public comment. The following is a brief summary of the issues that were discussed at the meeting.
Opening Remarks by David A. Longanecker, Assistant Secretary for Postsecondary Education, and Jamienne Studley, Deputy General Counsel for Regulations and Legislation
David Longanecker began by indicating that the Department needs rules of financial responsibility for three reasons. He indicated that the statute, as currently written, requires the Department to create financial responsibility standards that ensure that participating institutions are financially capable of providing the services they contract to offer as well as the administrative support to carry out those services. He also said that the Departments oversight experience shows that a significant percentage of potentially troubled institutions -- as much as one-third of the public and proprietary institutions and one-half of the private non-profit institutions that are currently being informally tracked -- are in such condition because of inadequate financial resources. Finally, Dr. Longanecker said that recent changes in accounting standards have made it necessary that we revise the current standards.
Jamie Studley, the meetings facilitator, outlined the agenda for the meeting and gave an overview of the work that has been done by the Department and KPMG Peat Marwick since the last meeting. She indicated that the Department and KPMG have (1) reviewed additional financial statements from recent years; (2) created a database to begin analyzing financial statements from institutions that have closed in order to better understand how such schools would score under the ratio methodology; (3) continued to meet and discuss issues with members of the higher education community to obtain comments and suggestions, including a meeting on February 27 with proprietary school owners and accountants representing individual institutions, chains, and approximately 100 client institutions; and (4) constructed and considered possible alternatives to the proposed ratio methodology that reflect comments and suggestions received.
Ms. Studley stated that the Department is working to change the current standards of financial responsibility because, based on its experience with the current regulations, the Department believes the rules can be improved to create standards that (1) reflect recent accounting changes; (2) better differentiate among the sectors to reflect business differences and capital structure; (3) are less susceptible to manipulation; and (4) provide a better picture of an institutions total financial situation by using a blend of financial factors consistent with reasonable business decision making.
Ms. Studley provided categories and data to help quantify the potential magnitude of Federal funds at risk due to a lack of financial resources at participating institutions, including losses at institutions that have closed, liabilities in final program review determinations that might be attributed to inadequate financial resources, and costs in terms of students investment in education that is sacrificed when schools cannot afford to provide minimum services or close before the student completes his or her program. Both the closed school and program review data include institutions from all sectors.
The Higher Education Act contains a discharge provision for loans made to students who attend institutions that close before the students program is completed. According to data in the National Student Loan Data System, in 1995 and 1996, $62 million of loans were discharged for 18,000 students because the schools that those students attended closed, representing potential losses for the federal government. In addition, failure to act as a fiduciary of Title IV funds is indicated in program review findings. One measure of the amount of Title IV funds at risk is the amount of program review liabilities levied. Over the past five years, nearly $700 million of program review liabilities have been assessed against institutions. Although, the precise reason for the school closings and the program review findings are not delineated further, the Department believes that an appreciable percentage of institutions that close did so because of financial problems and that a significant amount of program review liabilities were the result of administrative shortcomings brought about by financial difficulties.
KPMG distributed materials to the participants and introduced issues that the group discussed in more detail. KPMG Partner Herbert Folpe summarized work KPMG has done since the last meeting, including performing additional empirical testing on nearly 1,000 financial statements, meeting with many school representatives, researching various ratio analysis theories, and analyzing financial statements from closed schools.
Discussion of Issues and Suggestions
EQUITY RATIO AND VIABILITY RATIO. Mr. Folpe indicated that in response to many comments regarding the viability ratio, KPMG has seriously explored the possibility of either replacing the viability ratio with an equity ratio or adding the equity ratio so that the methodology would include four ratios. The equity ratio, defined as net assets divided by total assets for private non-profit institutions, and net worth divided by total assets for proprietary institutions, would add an institutions investment in property and equipment into the methodology, factors excluded in the three ratios proposed in the NPRM. The equity ratio gives credit to an institutions investment by including fixed assets in the calculation.
KPMG asked for input regarding the value and appropriateness of the equity ratio and whether participants thought that it should replace the viability ratio or be added to the methodology as a fourth ratio. In addition, KPMG asked whether adjustments should be made for intangible assets and permanent endowments.
Many participants stated that incorporating the equity ratio into the methodology provides a more comprehensive picture of an institutions financial condition. Others suggested that since the primary reserve ratio measures liquidity, the viability ratio is somewhat redundant and could be replaced. Furthermore, the adjustments for institutions with no debt would be unnecessary if the viability ratio is eliminated from the methodology.
KPMG also asked the group for input on potential strength scores with regard to the equity ratio. It provided initial data indicating that a sample of nearly half of all proprietary institutions with NPRM composite scores below 2.00 have equity ratios near 15 percent, signifying that potentially weak institutions are thinly capitalized. A similar sample of private non-profit institutions indicates higher levels of equity. KPMG indicated that it is considering the following strength factors ranges for the equity ratio after deducting intangibles and permanent endowment from the calculations:
Private Non-Profits
|Strength Factor Score
|Equity Ratio
|Strength Factor Score
|Equity Ratio
KPMG indicated that these strength factor scores are extremely preliminary and stressed the need for the community to provide suggestions and comments on what it thinks are appropriate break-outs. In response to a question about the effect of dropping the viability ratio from the methodology, KPMG commented that, for institutions with a material level of debt, the viability ratio and primary reserve ratio correlate to a certain degree.
INTANGIBLES AND ENDOWMENTS. With respect to intangible assets and endowments, some participants indicated that they should be included in the equity ratio. Specifically, it was suggested that goodwill, which can be acquired when an institution buys another institution, should not be deducted from net worth, as it is in everyones interest for good and financially healthy schools to take over bad and financially-troubled schools.
Comments were provided that the methodology could "haircut" goodwill, i.e., give full credit for goodwill in the first year and then reduce it in future years by a percentage that may be higher than the institutions amortization. KPMG stated that any increased amortization of goodwill over the institutions own amortization schedule would not be reflected in the primary reserve ratio. KPMG also suggested that the methodology could cap goodwill at a percentage of total equity. This would in part address the concern that many schools do not carry goodwill on their books, and therefore by increasing strength scores across the board to reflect this additional resource at some institutions might not be equitable. Several participants agreed that this is an important issue to consider. KPMG said that it would consider the percentage of the institutions that have goodwill as part of its analysis.
NET INCOME RATIO. One participant suggested that more weight be put on the net income ratio for private non-profit institutions. KPMG indicated that substantial increases in net income for private institutions may reflect schools implementing FASB 117 and 124. KPMG indicated that it thought net income for this sector should be weighted rather lightly because of the volatility of investment returns which are directly reflected on the institutions income statement. Other participants seemed to agree that where net income is largely dependent on market returns from endowment, it should not be given substantial weight.
OTHER STRENGTH FACTORS AND WEIGHTINGS. KPMG indicated that it is considering lowering the strength factors proposed in the NPRM based on the empirical data. Specifically, after analyzing more financial statements, the impact of private colleges adopting FASB 116 is not as significant as expected, especially for institutions that have little or no endowment. KPMG suggested that the strength factors for the primary reserve ratio and net income ratio be moved back to the fund accounting levels that were proposed for private non-profit institutions that had not adopted FASB Statements 116 and 117 in the NPRM. In addition, KPMG is considering, based on public comments and significant discussion from the February 27 meeting with the proprietary institutions, lowering the weight of the net income ratio for the proprietary institutions as well as lowering the strength factor thresholds for the net income ratio to incorporate net losses.
COMPOSITE SCORE SCALING. KPMG indicated that many comments were received about a "cliff effect" in the NPRM composite scoring process. For example, a private non-profit institution (under FASB 116/117) with a primary reserve ratio of 0.3 would receive a score of 3 for that ratio, yet an institution with a primary reserve ratio of .29 -- a very small difference -- would receive a score of 2. KPMG said that it is considering different options to lessen the burden of slightly falling below strength factor thresholds.
One alternative is to add significantly more thresholds, as many as 50 more, to strength factors between one and five. This could work similar to existing tax tables. Another alternative, which seemed to many participants to be easier to understand, is to create a linear algorithm that would reflect the slope of a straight line. In a related vein, strength factors could be revised to range from zero to five (instead of from one to five). This would allow for more differentiation at the bottom end of the scale which, the Department and KPMG indicated, could also be used by the Department to better target its oversight resources on at-risk institutions. Many participants suggested that these were good alternatives and agreed with the Department that ease of understanding is an important consideration in evaluating any alternative.
The Department and KPMG also suggested possible changes to the ratio methodology's scaling mechanism. Because greater definition is needed at the lower end than on the higher end of the scale for purposes of these regulations, it would be possible to rescale or reduce the number of strength factors, and truncate the assignment of composite scores, at the high end of the scale. By eliminating ordinal rankings at the high end of the scale, these adjustments could potentially eliminate concerns in the higher education community that data derived from the ratio methodology could be used for purposes for which the methodology is not intended. The Department indicated that it would consider this option in conjunction with its desire to create a differentiated system of statutory and regulatory relief based on administrative performance.
Z-SCORE. KPMG indicated that it is comparing its ratio methodology with the z-score methodology, a similar form of ratio analysis that is widely used as a predictor of bankruptcy in the manufacturing sector. KPMG explained that the z-score is a five-factor methodology that includes a measure of sales to total assets and is more appropriate, with respect to postsecondary education, to the proprietary sector than any other sector. It was noted that many representatives from the proprietary sector thought the z-score methodology was too complex. It was also noted that the calculation of the z-score requires elements not available on general purpose financial statements.
SECOND TIER ANALYSIS. Participants suggested that secondary or supplementary measures be incorporated into a final rule for institutions that fail to meet the composite score threshold indicating financial responsibility. Some participants stated that the nature of any secondary measures depends on where the "bright line" is set. KPMG and the Department indicated that the NPRM afforded an institution that received a composite score less than the "bright line" with the ability to continue to participate in the Title IV programs under certain circumstances. KPMG also suggested that almost all of the previous suggestions for supplementary considerations centered on equity. If the equity ratio is added to the methodology, these concerns may be alleviated. The Department and KPMG asked the participants for more comments and suggestions in this area.
Some participants suggested that the Department look carefully at creating a range of different kinds of requirements that it could place on institutions that failed the ratio methodology, including those that failed any type of possible secondary analysis. These participants suggested that there should be a range of requirements or sureties that the Department would allow these institutions to meet and continue to participate, a range which would be based on their level of risk, and which would be less stringent than the 50% letter of credit, provisional certification, or the proposed precipitous closure alternative. Representatives of the Department replied that while the focus of this meeting was on the proposed ratio methodology itself, the Department was also continuing to evaluate comments on the proposed alternatives within the framework of statutory requirements.
"BRIGHT LINE." Some participants asked whether KPMG and the Department have considered lowering the 1.75 composite "bright line" score. KPMG indicated that it has considered lowering the score slightly but stressed that setting the "bright line" will depend on many factors that are still under consideration. Specifically, the "bright line" will need to take into account whether the equity ratio is added to the methodology and whether it replaces the viability ratio or acts as a fourth ratio; whether the equity ratio incorporates intangible assets and permanent endowment; whether the methodology incorporates a linear component that alleviates possible distortions of a "cliff effect;" whether strength factors are relaxed to reflect the fund accounting ranges proposed in the NPRM; and whether strength factors are changed so as to range from zero to five (or zero to three) instead of from one to five.
AVAILABILITY OF DATA. KPMG and the Department agreed to disseminate strength factors and weighting of ratios under consideration on the world wide web. KPMG offered possible strength factors for the equity ratio during the meeting (see above). KPMG and the Department continued to ask the participants for comments and suggestions on possible strength factors and appropriate weights, and they stressed that the community need not wait for more information to be distributed before they provide suggestions.
ROUNDING TO TENTHS. KPMG and the Department asked whether the methodology would be made simpler or more understandable if the calculations and strength factors were restricted to tenths (i.e., one decimal point) rather than hundredths (i.e., two decimal points) as has be used thus far. Several participants stated that this would be a positive change.
TREND ANALYSIS. Comments were provided that a trend rather than a snapshot approach would generate a more accurate picture of an institutions financial health. KPMG indicated that the ratio inherently reflects prior performance. There were also concerns raised that trend analysis does not always indicate whether an institution is truly on a downward trend or if it is experiencing a temporary adjustment. In hindsight, it might be evident, but the Department would nonetheless face the potential problem of interpreting three years of an institutions steady performance followed by a moderate loss. KPMG also suggested that trend analysis could be added to the methodology, particularly with respect to the net income ratio, in the future.
PUBLIC INSTITUTIONS. Some participants asked about the treatment for public institutions. KPMG indicated that it has done limited analysis of public institutions. The Department said that it would organize a meeting with representatives of public institutions in the very near future to discuss how the rule will affect public institutions. The Department indicated that any relaxation of the rules for public institutions would not relieve them from the requirement to provide annual financial statements. Participants commented that the final rule should be more specific about what constitutes "full faith and credit" to account for the potential weakness of the supporting governmental entity. Similarly, the Department should have the flexibility to consider whether the supporter is financially healthy and has taxing authority. Another participant suggested that the Department analyze the bond ratings of public institutions as well as the bond rating of the affiliated state governments.
<<Financial Responsibility Page


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ICE Arrests Operator Of Seized Domain; Charges Him With Criminal Copyright Infringement
from the is-there-secondary-criminal-infringement? dept
About the only thing that could be claimed is some sort of "inducement" claim -- but as we discussed recently, there's simply no such thing as criminal contributory infringement, so if that's the claim, then it would appear that ICE (yet again) is simply making up what it wants the law to be, rather than what the law actually says. Now, there may be more to this than has been made clear to date. Perhaps there's evidence that the site actually did host content, but that was not clear from what I saw earlier. Some have said that there's an "aiding and abetting" charge to be made under criminal law, but as we pointed out in the link above, the standard for aiding and abetting are much, much higher, and there's little evidence that ICE has enough to meet the aiding and abetting standard.
On top of this, there are serious questions about why this should be a criminal claim, rather than a civil claim. ICE appears to be using the fact that the guy, Bryan McCarthy, made some money, from ads on the website, as the basis for the criminal charges. But that seems like a stretch (at best). While we still question why there should even be such a thing as criminal copyright infringement, even if we accept the idea that it does exist, isn't it supposed to be focused on those doing significant behavior where the connection between the infringement and the money making is clear and direct? Putting some ads on a website that earn a small amount of money (as is the case here) shouldn't be enough to trigger criminal infringement claims. Anyone can put ads on a website. That, alone, shouldn't shift liability from civil to criminal.
No matter what, this will represent a lawsuit worth watching. I'm always nervous that tough cases make bad law, and I could definitely see how certain aspects of this case could obscure the key issues. It will come as a surprise to no one that I'm greatly troubled by a criminal charge here, but it should worry almost anyone who has a website and has ever embedded videos. I have, for example, frequently embedded YouTube videos on this site -- and some of those videos might have been infringing. On top of that, I make some money from advertising on this site. Does that mean I now face criminal liability? I certainly hope not, but that seems to be the incredibly chilling message that ICE is sending. It immediately makes me question if I can ever embed another video without first getting explicit permission from the copyright holder.


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Evidence-based health care
|hlwiki.ca? contact: email@example.com
To browse other articles on a range of HSL topics, see the wiki index.
See also Evidence-based web 2.0, Point of care decision-making tools - Overview and Systematic review searching
According to the Centre for Evidence-Based Medicine (CEBM) and David Sackett: "Evidence-based medicine is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients". The term Evidence-based medicine often includes the synonymous terms evidence-based health care and evidence-based practice and can be extended to nursing, pharmacy, physiotherapy, and allied health. EBHC may also refer to evidence-based management of health services, programs and people (ie. Health Services Research) as well as technologies used to aid health care practice (ie. Health Technology Assessment). Evidence-based practice is known throughout the world but the study of health services research and health technology assessment is relatively unknown. When health professionals refer to best evidence they are referring to major clinical studies & trial types that use explicit and reproducible methodologies.
In biomedicine, the scholarly communication cycle begins with new ideas about how to treat patients (ie. using new drugs) or clinical problems. Researchers start by writing grant proposals and making formal application to funding agencies. Often, the key to funding stems from gathering the evidence, identifying new areas or 'gaps' in medical knowledge and formulating clear research questions. After these questions are posed, identifiable goals and objectives in research are developed. Once research funding is secured and the research itself conducted, the researcher engages in the formal sharing of findings by publishing articles in peer-reviewed journals or scholarly monographs. Research publications provide the foundation from which future scholarship is carried out and directed, commencing once again in the process described above.
EBM Explained by Dr. Marc Ebell
Evidence-based practice (EBP)
See also Evidence-based medicine - history
The phrase evidence-based medicine dates back to a 1992 article by Gordon Guyatt et al. EBM is now a worldwide movement that affects all areas of clinical medicine including education and management. Simply put, EBM seeks to locate and apply evidence from the published medical literature to guide physicians in their decision-making. Some synonyms for EBM include evidence-based practice (EBP) and evidence-based health care (EBHC). There are three distinct but interdependent areas of evidence-based practice; the treatment of individual patients, supported by scientifically valid studies in the literature; practitioners should select treatment options based on the best available scientific research; the second area is a systematic review of literature to evaluate the best studies. This process is human-centered, but also involves computers for information retrieval and statistical analysis. The ability to judge the quality of the medical literature on finding it is central to EBM including what facts can be inferred from it, to appreciate the strength of those inferences, and to apply them to particular patients. As medicine has continued to grow and become more specialized, the number of medical specialties has increased. At the same time, the amount and complexity of the medical literature has also grown. In this sense, evidenced-based medicine can be considered a burgeoning medical specialty, with the medical literature itself - and its efficient retrieval, and appraisal - the object of study. Two of the other scientific issues that have an impact in EBM: 1) the generalizability of research (extent to which results of a study are applicable to other populations); and 2) was the research done using rigorous methods and is it reproducible? Finally, EBM may be understood as a "movement" where advocates popularize its methods and usefulness for patient communities, educational institutions and practicing professionals.
Five (5) steps of EBM - see [1]
EBM and librarians
PICO - sensible, focused questions
The PICO acronym (patient/population; intervention; comparison; outcome) is used by health professionals and librarians in providing direction for step one of EBM. The PICO framework - diagram guides EBM as it combines elements of the clinical scenario in an orderly fashion. The goal, of course, is to build a focused, answerable clinical question:
Generally speaking, health librarians use the most relevant terms, keywords and concepts from PICO to find the best evidence. Several resources are available to introduce EBM concepts and to guide you through the process of shaping your information need into a clinical question.
For other examples, see:
Randomized controlled trials
See Major clinical studies & trial types
A randomized controlled trial (RCT) is a clinical trial or scientific study used in the testing of the efficacy of medicines or medical procedures. The RCT is widely considered the most reliable form of scientific evidence because it is the best known study design for eliminating a variety of biases that regularly compromise the validity of medical research.
Systematic reviews (SRs)
Systematic reviews are generally viewed as the highest level of medical evidence for they bring together major randomized controlled trials in a given area, pool results (which may include a meta-analysis) and review their efficacy. An understanding of SRs and how to implement them in practice is mandatory for all health professionals. SRs are summaries of the literature based on expert searching. A literature review is followed by an in-depth critical appraisal of individual studies to identify the most valid and applicable evidence. Finally, appropriate techniques are applied to combine these valid studies in the SR. Many SRs are based on an explicit quantitative meta-analysis of data, but there are qualitative reviews which adhere to the standards for gathering, analyzing and reporting evidence. Many healthcare journals now publish SRs, but the best-known source is the Cochrane Collaboration, a group of over 6,000 specialists who systematically review biomedical trials and the results of other research. Cochrane reviews, based on explicit meta-analyses, are published in the Cochrane Database of Systematic Reviews section of the Cochrane Library, which has over 3000 complete reviews. The Cochrane Group provides a handbook for systematic reviewers where guidelines indicate appropriate content. The Alberta Research Centre for Child Health Evidence provides an overview of EBM terms taken from the Cochrane Reviewer's Handbook.
Canadian context
McMaster University in Ontario, Canada is arguably the birthplace of evidence-based medicine. Several major figures meet there every summer for a series of workshops including Gordon Guyatt, Deborah Cook, Victor Montori, Scott Richardson, Holger Schünemann and others. Many health librarians have attended this annual pilgrimage but there are a number of McMaster health librarians who help to integrate guest health librarians into the How to teach EBCP workshop - they are Liz Bayley, Neera Bhatnagar and others.


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Charles R. Swindoll has devoted his life to the clear, practical teaching and application of God's Word. He currently pastors Stonebriar Community Church in Frisco, Texas, and serves as the chancellor of Dallas Theological Seminary. His renowned Insight for Living radio program airs around the world. Chuck and Cynthia, his partner in life and ministry, have four grown children and ten grandchildren.


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The definitive online guide to Heuer chronographs and dashboard timepieces
What's New! - Twitter - Blog - Best of OTD - Collection - Discussion Forum - Sales Forum
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Complete Idiot's Guide to Getting a Tattoo
Considering Pat Sullivan, our resident "I-Swear-I'm-Not-A-Hipster" blogger, will soon be interviewing John Reardon, I felt it fitting to revisit the tattooist's book The Complete Idiot's Guide to Getting a Tattoo.
Released last year, John walks readers through every step of the process, from deciding on the art and artist, to physically prepping for the event, to aftercare. It's a comprehensive guide for first-timers, which also features his own tattoo art and designs.
For those looking to get tattooed by John, he now divides his time between Saved Tattoo in Brooklyn and Bright Side Tattoo in Copenhagen, Denmark (ya know, just the next exit on the Brookly-Queens Expressway). Pat will have more on the artist coming soon.
While John does a great job with the book, I did want to add five tips, rather warning signs, on when walk away from the needles:
1. If the studio slogan is this: "If You Can't Run With The Big Dogz, Go Piss With The Puppies," walkz away.
2. If the design has you feeling less like Megan Fox and more like Meghan McCain, walk away.
3. If your tattoo artist has a "degree" from the Las Vegas Ink School, walk away. In fact, if you are prone to seizures, don't even click the animated Giff-laden site for the school.
[Thanks, Chris, for the link and headache.]
4. If the artist's portfolio is consistently featured on the Fail blog, walk away.
5. Finally, if your tattoo artist looks like this and is willing to tattoo a full constellation on your young face, walk away. Or at least walk away from the media blitz.
5 Comments


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Almost all errands require a car.
About your score
This location has a Walk Score of 14 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
Nearby parks include Taos Canyon Historical Marker, Taos Plaza End of the Camino Real and Kit Carson State Park Cemetery Historical Marker.
Explore how far you can travel by car, bus, bike and foot from this location.


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[url=http://www.perldoc.com/perl5.6.1/pod/func/grep.html]grep is an operator that uses an expression to search a list. The expression in this case is { /\.(jpg|gif)$/i } (files that end jpg and gif files only). This expression needs to know what directory to look in, and [url=http://www.perldoc.com/perl5.6.1/pod/func/glob.html]glob takes care of that by using the wildcard * to look at all files that directory. The brackets around this entire expression create an anonymous array, which is passed to the [url=http://www.perldoc.com/perl5.6.1/pod/func/map.html]map line because map also works on a list.
So this line is now working on the results of the grep line (an anonymous array). All it's doing is selecting and returning a random element in the anonymous array.
-- Frodo
map { $_->[rand@$_] } ['red', 'green', 'blue', 'yellow'];
$ref = ['red', 'green', 'blue', 'yellow']; $ref->[rand @$ref];
@ary = ('red', 'green', 'blue', 'yellow'); $ary[rand @ary];


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Don't be surprised if gaggles of screaming teens suddenly make a rush on Orioles gear.
Their icon, "Twilight" star Kristen Stewart, has been photographed in an Orioles hat all over the place.
It turns out that Stewart has apparently swiped the orange and black headgear from her boyfriend, co-star Robert Pattinson. (Robert Pattinson??? Aaaaaaaah!!!)
Yahoo's Crush blog is reporting that the hat-grab is a meaningful indicator of the couple's true love.
"While some girls snag their boyfriend's favorite button-down shirt or perfectly broken-in sweatshirt, Kristen Stewart seems to have taken possession of Robert Pattinson's prized ball cap," Crush...


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Want to see what Great Lakes CrossFit is all about? Come check us out for free this Saturday at 11:00 am for a free basic introductory class. The class is open to all ages and ability levels. The class will last no longer than one hour and consists of a warm up, instruction on movement, workout and cool down.
The entire time you will be supervised by a CrossFit certified trainer that will watch to make sure you are doing the movement properly, staying safe, and pushing yourself as hard as you can. There is no need to register ahead of time, simply show up and be ready for a workout.
Also, this Monday September 17 at 7:00 pm we will be having a yoga class that is open to all. The class will be taught by member and Yoga Instructor Jessica Jerome. The cost is $7 for members and $12 for non-members. Feel free to contact us with any questions. YOU MUST REGISTER FOR THE YOGA CLASS AHEAD OF TIME. You can do this at the gym or by contacting us.


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Harold Cunningham/Getty
Tom Ford is a dad!
The fashion designer and his partner, journalist Richard Buckley, "are proud to announce the birth of their son, Alexander John Buckley Ford, born in Los Angeles on Sunday, Sept. 23," his rep tells PEOPLE.
Ford, 51, is often credited with the turnaround of Gucci during his 10-year run as creative director of the label, a role which ended in 2004. He and Buckley, 64, have been together since 1986.
"If I have children, no one will know about it until the child is born. And no one will ever see the child because I certainly wouldn't use it as a press tool," the designer and director of A Single Man said in a 2011 interview with Time Out Hong Kong.
"If I have a child, you won't notice that I had a child. Maybe you'll see it when it's 18, but I will keep it out of the spotlight."
— Sarah Michaud


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Buntport's first Denver Center reading set for June 11
The first reading of the new play being developed by Buntport Theater as a commission for the Denver Center Theatre Company will be held at noon Friday, June 11, in the Jones Theatre, located at 13th and Arapahoe streets.
DCTC artistic director Kent Thompson has commissioned the award-winning Buntport Theater, which for nine years has presented only original works, to develop and create an multimedia production centering on Nikola Tesla.
The Buntport ensemble is collaborating on the project with the DCTC's resident multimedia specialist, Charlie Miller.
"This is an opportunity for members of the audience to experience an innovative new play in the early experimental stages," the DCTC said in a press release.
Read more…


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We've found it – the ULTIMATE man-cave accessory
Who among you can top this Aussie multimedia-electro-tool-chest?
A shed or workshop is an intensely private place where the normal rules of domesticity do not apply.
There's no need for flowers, candles or frippery. Just solid, practical kit that offers a place for everything so you can keep everything in its place.
Those rules do not, however, mean that your man-cave has to be devoid of fun items. Vulture South is happy to make that adjustment to the rules now that we've found the "Ultima 15 Drawer Stainless Steel Tool Workshop".
Here's the 1330 x 580 x 1760mm beast in all its glory.
The Ultima Tool Chest
That panel with the maker's name at the top is not just a poster: it's a 22 inch LCD television.
Yes, that is a fridge. And you could have a drawer full of bottle openers
There's another notable inclusion: a DVD/CD player and stereo system, the latter ready to accept input from just about any device and pump out the results from a pair of Pioneer speakers.
The Ultima Tool Chest's CD/DVD player
To summarise: this is a colossal tool chest that stands 176cm high, includes a television, fridge and sound system. There's also gas struts to hold up the lid and four lockable heavy duty castors.
Some may lament the absence of a video input as leaving the Ultima short of perfection. A price tag of $AUD5,500 may also deter some, although Vulture South spotted one in the wild for $AUD2,999.
Our challenge to you, dear readers, is simple. If you know of or have built a finer piece of shed furniture than the Ultima, let us know. The comments are waiting for you, or you can contact the author directly. Send or link to photos so we can show off whatever it is you think tops the Ultima and we'll round up the best results next week.
If you want an Ultima, details can be found here. ®


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Striped Light
Joy Rector 12/26/2012 8:37:56 AMwow, love it #1505358
Melinda F. Schneider 12/26/2012 8:53:16 AMThank you, Joy.
John Rivera 12/26/2012 9:20:02 AMFabulous image! #10479347
Melinda F. Schneider 12/27/2012 4:44:00 AMThank you, John. #10480289
My grandson, seen through the shadows of a venetian blind.
Uploaded on 12/26/2012 6:46:54 AM
Camera: Nikon D40x Digital SLR Camera
Copyright for this gallery photo belongs solely to Melinda F. Schneider. Images may not be copied, downloaded, or used in any way without the expressed, written permission of the photographer.
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