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BOSTON, Mass. – Richard Prevost and Gihan Amarasiriwardena finished one-two but it was not enough, as the MIT men's cross country team finished second behind RPI at the Engineer's Cup on Saturday afternoon. RPI secured places four through nine for a total of 30 points, eight better than the Cardinal and Gray's score. WPI was third with 69 points.
Prevost finished three seconds ahead of Amarasiriwardena with a time of 26:39 on the eight-kilometer course. Matthew Metlitz was the next Tech runner across the line, in 10th place with a time of 27:10. Jacob Young came through the chute 10 seconds later and in 12th. He was followed by Logan Trimble (27:28) in 14th.
MIT travels to UMass-Dartmouth next Saturday, September 18 for an invitational meet beginning at 12:00 p.m.


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Jack Reynor bulking up for Transformers 4
- Bang Showbiz
- 21 January 2013
Irish actor Jack Reynor has revealed he is undertaking intense physical training for his role in 'Transformers 4' opposite Mark Wahlberg
Jack Reynor is bulking up for his role in 'Transformers 4'.
The up-and-coming Irish actor was cast by Michael Bay in the latest instalment of the robot franchise earlier this month, and he has revealed he is undertaking an intense physical regime to prepare for his role in the film.
Speaking to BANG Showbiz at the London Critics Circle Film Awards last night (20.01.13) at the May Fair Hotel, he said: "I'm training very intensely at the moment. I'm going to keep that up until we shoot. I'm going to do some different courses, some different things I need to pick up for the film. My character seems to be a race car driver so I'm going to be doing a couple of driving courses and getting out on the track."
Quizzed about how he landed the role, he added: "It was after a film I was doing, 'The Delivery Man', with Dreamworks. I went through quite a rigorous audition process out in L.A., and after a certain amount of auditions and meetings with different executives, I managed to pull it off."
The 20-year-old 'What Richard Did' actor - who was hailed by director Michael as the "real deal" - hasn't met co-star Mark Wahlberg yet, but admits he greatly admires the 'Ted' star.
He said: "I haven't met him before, but I'm really excited. He's one of my favourite actors. I just think he's brilliant. I have a huge amount of respect for him as an actor so I can't wait to get on set with him."
Although the film's lead character has yet to be cast, Jack insists he trusts Michael, who is credited with making household names out of Megan Fox and Rosie Huntington-Whiteley, to pick the franchise's next beauty.
He said: "I think Michael Bay has his ideas about it and I'm going to go along with him. He seems to know what he's doing."
'Transformers 4' is rumoured to begin filming in May for a tentative June 2014 release.
Other stars who attended the glitzy awards ceremony included Helena Bonham Carter, Samantha Barks, Toby Jones, Emily Blunt and Tom Holland.

subset: commoncrawl


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April 19, 2015
For some time now we have been working very closely with the Congolese Solidarity Campaign. We have been working to build a politic from below that accepts each person as a person and each comrade as a comrade without regard to where they were born or what language they speak. In this struggle we have faced constant attack from the state, the ruling party and others.


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Hero Cops Hurl Black Politico to the Ground
[There was a video here]
This past weekend, all New Yorkers were in grave danger of being shot by rampaging gunmen driven wild by the melodic tunes of the West Indian Day Parade. (Sarcasm. This is sarcasm.) The NYPD did its part to keep us safe, by manhandling various black political officials.
Jumaane D. Williams, a New York City Councilman, and Kirsten John Foy, an senior aide to public advocate Bill De Blasio, were handcuffed and detained by NYPD officers, who were apparently unconvinced that the two were, in fact, allowed to walk on a certain sidewalk, which they had been given permission to use by another police officer earlier, who apparently knew who they were. Foy was thrown to the ground, which can be seen on the delightful video above.
The STUNNING TWIST to this story: both men are black. And Williams even has dreadlocks. So. Oldest Story In The Book goes here.


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September 7, 2004
I believe that the SEC should withdraw its rule exempting broker-dealers from the Investment Advisers Act of 1940 when offering fee-based brokerage programs.
Having a different standard or policy for two distinct groups offering the same service does not offer the investing consumer adequate protection. Further, it weakens the standard of fiduciary duty owed to the customers of the investing community.
Please reconsider the stance that you have taken.


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Difference between revisions of "Utica"
Revision as of 14:19, 18 August 2009
Utica [1] is a city in Central New York.
Utica is a city of approximately 60,000 residents in Oneida County, NY, located along the Mohawk River, the Erie Canal, and the New York Barge Canal. It is the seat of government for Oneida County. The site was originally settled in 1758 as Old Fort Schuyler. The current name, Utica, comes from an ancient north-African city, once Rome's capital within Africa.
Historically an industrial center, it was particularly well-known for textile production, though this has declined in recent years.
A few interesting facts: Utica holds the Guinness World Record for "Biggest Doughnut," a monster 1.5-ton jelly doughnut prepared in 1993 by local bakeries and a local radio station. It has also appeared in the movies, as the setting for "Drums Along the Mohawk" (1939) and the filming location for "Slap Shot" (1977). Well-known actress/Mouseketeer Annette Funicello was born in Utica.
Utica is in the Eastern Standard time zone, and is located at latitude 43.100N, longitude -75.233W.
Get in
By plane
Hancock Airport (Syracuse) or Albany International Airport- the small regional airport in Utica is no longer in operation, the Oneida County airport (Oriskany) has recently moved and is now located in Rome, which has over a 10000 foot runway (at the former Griffis air base). The former location in Oriskany is now a Homeland Security training center.
By train
Amtrak out of Union Station, an historic train station in downtown Utica.
By car
Utica is easily accessed from the New York State Thruway.
Get Around
Running Events
As home to the National Distance Running Hall of Fame, you'd expect Utica to have some notable running events - and it does.
Utica has several colleges/universities whose programs may be of interest to potential students.
Utica has a wide variety of bars, with many of the most popular being in the Varick St area of downtown. Although popular with residents year round, expect the bars around Varick St to be particularly crowded during Saranac Thursdays.
Varick St Bars
Genesee St Bars
Get Out


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I am not familiar with the one you have so I have no clue what the problem is. How about this one.http://www.ebay.com/itm/L298N-Dual-H-Bridge-IC-Stepper-Motor-Driver-Controller-Board-Module-for-Arduino-/300864612676?pt=LH_DefaultDomain_2&hash=item460ceda944
Quote from: HazardsMind on Feb 23, 2013, 03:44 amI am not familiar with the one you have so I have no clue what the problem is. How about this one.http://www.ebay.com/itm/L298N-Dual-H-Bridge-IC-Stepper-Motor-Driver-Controller-Board-Module-for-Arduino-/300864612676?pt=LH_DefaultDomain_2&hash=item460ceda944With a 298 in there he's going to lose 2-3 volts at the motors straight off the top....Btw, have you tried to code the acceleration in, as I suggested and as you elaborated in code earlier?And tried it on a floor with no carpet? As the wheel sinks in the pile, as it moves off it has to flatten the pile in front and that takes energy.
Yes I did it didn't work, the problem is not accelerate or the code. The motor driver kept shutting off from over heating, I guess the motors were drawing more than 2.5 amps, and the motor driver couldn't handle it.
I just cant grasp how a fan over my motor driver will help my robot drive? will a fan really cool off the warming of current that much?and I'm just trying to learn and ask here dont fight me lol


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Discover a place that CNN ranked as a top ten world destination for 2012.
We offer an array of employee benefit options. View our Employee Benefit Handbook for details or view an itemized listed below for specific information. If you are a new employee enrolling in medical, dental and vision benefits, there is a 60-day waiting period before your coverage begins, and you will have 30 days from the date of hire to sign up for your benefit elections.
1-800-244-6224 Cigna's Hotline is open 24 hrs 7 days.
Onsite Representative: firstname.lastname@example.com or call 407-836-3271
2018 Cigna Health Plan Documents
2018 Cigna Dental Plan Summaries
Spending Accounts
Vanguard Items
Florida Retirement System
You must submit your application to The Standard and make your first payment within 60 days of your termination from the County.
For additional information, please review these Frequently Asked Questions or contact The Standard at (800) 378-4668


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GPPAC deeply concerned about persecution of Russian Peace activist Valentina Cherevatenko
GPPAC is expressing its deepest concern about the possibility of criminal charges being brought against Ms. Valentina Cherevatenko, an outstanding Russian peace activist, a long-term GPPAC member and the chair-coordinator of the NGOs Union "Women of the Don Region" and head "Women of the Don Foundation for Civil Society Development". She has also played a leading role in the ongoing conference "Women for a Life without Wars and Violence" since 1996. This is a platform for joint peacebuilding and humanitarian activities of many organisations and activists from post-soviet states, especially Southern Russia and countries of the South Caucasus.
You can read and share the whole statement by downloading it here in PDF.
For the version in Russian, click here.


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If you are a subscriber to the JCSM (including members of the AASM), please login to access the journal.
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Join the American Academy of Sleep Medicine and receive a subscription to JCSM with your membership
We report on two sisters, 17 and 12 years of age, with clinical features suggesting narcolepsy with cataplexy (NC): daytime sleepiness, spontaneous and emotionally triggered sudden falls to the ground, and overweight/obesity. MSLT showed borderline sleep latency, with 1 and 0 sleep onset REM periods. HLA typing disclosed the DQB1*0602 allele. Video-polygraphy of the spells ruled out NC diagnosis by demonstrating their easy elicitation by suggestion, with wake EEG, electromyo-graphic persistence of muscle tone, and stable presence of tendon reflexes (i.e., pseudo-cataplexy), together with normal cerebrospinal hypocretin-1 levels.
Our cases emphasize the need of a clear depiction of cataplexy pattern at the different ages, the usefulness of examining ictal neurophysiology, and collecting all available disease markers in ambiguous cases.
Pizza F; Vandi S; Poli F; Moghadam KK; Fran-ceschini C; Bellucci C; Cipolli C; Ingravallo F; Natalini G; Mignot E; Plazzi G. Narcolepsy with cataplexy mimicry: the strange case of two sisters. J Clin Sleep Med 2013;9(6):611-612.
Narcolepsy with cataplexy (NC) is a rare hypersomnia of central origin characterized by daytime sleepiness, cataplexy (sudden losses of muscle tone triggered by emotions, pathognomonic symptom), and other REM sleep disturbances. Reduced levels of cerebrospinal hypocretin-1 (hcrt-1 < 110 pg/mL) or ≥ 2 sleep onset REM periods (SOREMP) at MSLT should, "whenever possible" confirm NC diagnosis according to the International Classification of Sleep Disorders (ICSD-2).1 We report two ambiguous cases who were sent to our center with suspected NC, claiming the need to document accurately cataplexy features within NC assessment.
Patient 1 is a 17-year-old female presenting with frequent episodes (up to 5-6 per day) of sudden shortness of breath since age 13 years, followed by occasional apparent loss of consciousness. Since 14 years of age, she has had sudden falls to the ground, occurring both while standing or sitting and elicited by emotions, with immobility for up to few minutes. After an initial cluster, episodes frequency settled to 1-2 per month. She also increased weight and, at 16 years, daytime sleepiness appeared. At our observation she had a BMI of 31.24 kg/m2 and an Epworth Sleepiness Scale (ESS) score of 12. Cardiological evaluation and testing and brain MRI were normal. During 48-h polysomnography (PSG) she had SOREMPs in both daytime and nighttime sleep in the absence of sleep disordered breathing (apnea-hypopnea index [AHI] of 0/h). MSLT showed borderline sleep latency (9 min) with 1/5 SOREMP. Human Leucocyte Antigen typing revealed the HLA-DQB1*0602 allele. A typical spell, evoked by a suggestion maneuver, was recorded during video-PSG, showing ictal persistence of EMG muscle tone, deep tendon reflexes, and normal wake EEG (Video 1). Hcrt-1 level was in the normal range (364.4 pg/mL). A diagnosis of NC was excluded. Since we communicated the noncataplectic nature of the spells, their frequency has decreased to 2-3 episodes per year.
Video 1 shows an instance where Patient 1 was standing while a placebo suggestion was performed. She abruptly fell on the ground—EMG showed initially increased then persistent muscle tone, and EEG, partially masked by artifacts, showed wake activity. While Patient 1 was recumbent and apparently unconscious, brisk reflexes could be easily evoked, confirming the non-cataplectic nature of the spell. The episode ended after another suggestion maneuver and while the doctor was reassuring Patient 1 that the episode would soon vanish. Polygraphic montage included EEG (C3-A2; O1-A2; Cz-A2), EOG (ROC-A1; LOC-A1), EMG (chin, right masseter, nuchal, right sternocleidomastoid, right and left deltoid, right and left carpus extensor, right and left anterior tibial muscles), ECG, and thoraco-abdominal belt from the top to the bottom.
Patient 2, the 12-year-old sister of Patient 1, had sudden episodes of vertigo followed by apparent brief loss of consciousness and falls to the ground with unresponsiveness to external stimuli for a few seconds to some minutes since 11 years of age. These episodes, after an initial cluster of 10 per day over a week, decreased to 1-2 per day. According to parent's report, the episodes were similar to those of Patient 1. Psychiatric evaluation disclosed attention deficit hyperactivity disorder (ADHD), and normal head-up tilt table test excluded vasovagal syncope. At our evaluation, she complained mild restless legs symptoms and daytime sleepiness (ESS score of 15); sleep talking since childhood was reported. Her BMI was 29.7 kg/m2. MSLT showed borderline sleep latency (9 min 12 sec). No SOREMP occurred during daytime or nighttime sleep on 48-h PSG (AHI = 0/h). She was HLA-DQB1*0602 positive and had normal brain MRI. Video-PSG of a spell occurring while watching funny videos showed persistence of wake EEG activity, EMG muscle tone, and deep tendon reflexes (Video 2). Hcrt-1 was in the normal range (253.7 pg/mL). Atomoxetine was given for ADHD, and she reported improved daytime sleepiness and significant spells reduction (1-2 per month).
Video 2 shows an instance where Patient 2 was standing and watching funny videos and abruptly fell on the ground— EMG initially showed a reinforcement then a persistence of muscle tone and EEG, masked by artifacts, wake activity. While Patient 2 was recumbent and unresponsive to external stimuli, osteo-tendinous reflexes could be easily evoked, also when muscle tone was apparently of low amplitude on EMG channels. Polygraphic montage included EEG (C3-A2; O1-A2; Cz-A2), EOG (ROC-A1; LOC-A1), EMG (chin, right masseter, nuchal, right sternocleidomastoid, right and left deltoid, right and left carpus extensor, right and left anterior tibial muscles), ECG, and thoraco-abdominal belt from the top to the bottom.
Our cases show that the diagnosis of cataplexy based on clinical history alone may be misleading and suggest the need to further frame cataplexy and its mimics by documenting the episodes in the diagnostic work-up of suspected NC. According to ICSD-2, MSLT should be performed in the absence of a definite history of cataplexy, and HLA typing is neither sensitive nor specific for NC diagnosis confirmation.1 Indeed, as cataplexy is easy to document and peculiar, especially in children close to disease onset,2 we suggest the need to search for it considering ictal video-PSG useful in uncertain cases,3 and also for phenotype-genotype research purposes. NC objective biomarkers, namely SOREMPs and low/undetectable hcrt-1, have to be investigated in all challenging patients, and normal hcrt-1 may occur only in peculiar cases.4 Differential diagnosis of cataplexy should include a careful work-up to rule out cardiovascular conditions such as vasovagal syncope,5 drop attacks,6 and epilepsy.7 Misdiagnosing as NC other neurologic or psychiatric disorders, or cases of malingering, may have serious consequences for patients and their families, as well as high costs for the society. Overlaps between NC and psychiatric traits3 or disorders8 may also exist and require multidisciplinary approach and further investigations.9
This was not an industry supported study. Dr. Plazzi has consulted for UCB Pharma and JAZZ Pharmaceuticals. Dr. Mignot receives research support from GlaxoSmith-Kline, Jazz Pharmaceuticals, and Novo Nordisk. The other authors have indicated no financial conflicts of interest.
Work for this study was performed at Dipartimento di Scienze Biomediche e Neuromotorie (formerly Dipartimento di Scienze Neurologiche), Via Ugo Foscolo 7, 40123, Bologna, Italy.
American Academy of Sleep Medicine. International classification of sleep disorders: diagnostic and coding manual. 2005. 2nd ed. Westchester, IL: American Academy of Sleep Medicine;
Plazzi G, Pizza F, Palaia V, et al., authors. Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain. 2011;134:3480–92. [PubMed]
Plazzi G, Khatami R, Serra L, Pizza F, Bassetti CL, authors. Pseudocataplexy in narcolepsy with cataplexy. Sleep Med. 2010;11:591–4. [PubMed]
Khatami R, Maret S, Werth E, et al., authors. Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway. Lancet. 2004;363:1199–200. [PubMed]
Totah AR, Benbadis SR, authors. Gelastic syncope mistaken for cataplexy. Sleep Med. 2002;3:77–8. [PubMed]
Plazzi G, Tonon C, Rubboli G, et al., authors. Narcolepsy with cataplexy associated with holoprosencephaly misdiagnosed as epileptic drop attacks. Mov Disord. 2010;25:788–90. [PubMed]
Plazzi G, Tinuper P, authors. Praxis-induced seizures misdiagnosed as cataplexy: a case report. Mov Disord. 2008;23:2105–7. [PubMed]
Miano S, Parisi P, Villa MP, authors. The sleep phenotypes of attention deficit hyperactivity disorder: the role of arousal during sleep and implications for treatment. Med Hypotheses. 2012;79:147–53. [PubMed]
Fortuyn HA, Mulders PC, Renier WO, Buitelaar JK, Overeem S, authors. Narcolepsy and psychiatry: an evolving association of increasing interest. Sleep Med. 2011;12:714–9. [PubMed]


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Geiger is committed to product safety because it's too important not to be. Geiger is a socially conscientious company that has been in operation for over 130 years. We appreciate your business and are taking measures to maintain your confidence and trust in our services. You deserve a company that does the best job of providing proactive, comprehensive compliance solutions.
Click here to learn more about Geiger's commitment to safety.
Geiger has a full-time Product Safety department committed to protecting you and your brand. We strive to provide products that are in compliance with the Consumer Product Safety Initiative (CPSIA), Proposition 65 requirements and the US Food and Drug Administration (FDA). Our goal is to enhance and protect your brand, not put the reputation of your brand at risk. You can trust Geiger!
A number of high-profile news events have brought to light areas of concern that could potentially impact anyone who distributes products manufactured overseas. As a result, here are the initiatives we are taking to insure the safety of the products we distribute:
We have strong relationships with our production partners. These vendors have years of proven experience and are proactive in many areas, including product safety and social compliance. They have put their products through testing beyond that being done by inspectors overseas.
We feel that it is not enough that our key production partners monitor their overseas production facilities. We are also taking on active role by doing factory visits to see firsthand how the products are manufactured, to ensure safe working conditions and responsible labor practices are being met. We also work with FLA-certified sources of supply that have to go through regular, rigorous, independent testing to ensure factories are safe and do not employ "sweatshop" labor practices or child labor.
In some cases an independent testing process is available to further validate prior testing results. These products are tested for lead content as well as other chemicals that could be harmful for the user. Products that will be used by children are tested for child safety. Many of the items tested are products that we use on a regular basis for programs and clients nationwide.
OUR COMPANY'S COMMITMENT TO ETHICAL AND RESPONSIBLE CONDUCT Our Company believes we must not only meet the expectations of our customers and consumers, we must exceed those expectations. To that end, we have adopted standards for the safety, quality and integrity of our products and processes and we are committed to respecting the rights of individuals and protecting the environment. We are dedicated to complying with all applicable laws and to conduct business in an ethical and responsible manner.


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Sleep Style: Pretty Sleeping Bags
Lovely prints and soft fabrics make for some unexpectedly nice sleeping bags. They might not be great for serious camping, but they're perfect for wherever else your travels may take you, or for extra guests.
- Admittedly, this one is a bit pricey. But hey, if it's in your price range, it sure is beautiful. $487 at Scout Seattle.
- A gorgeous, hand-tied option that opens into a Full sized duvet. $209 at Good Intent.
- Perfect for summer nights in a platform tent. $99 at Fabrik.
- A muted, cloud-patterned option, $60 at love mae.
- Horses gallop across a memorable, graphic sleeping bag. Approximately $95 at Anorak.
Images: As linked above.
Apartment Therapy supports our readers with carefully chosen product recommendations to improve life at home. You support us through our independently chosen links, many of which earn us a commission.


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Friday night in Sydney just got wilder. .. with glamorous dancers, tonnes of confetti, blasts of CO2, suspended jungle vines and golden animals, Marquee Zoo has arrived. The new face of Friday nights at Marquee, Zoo features pumping party music you can get down and dirty to, coupled with a crazy party atmosphere unlike anywhere else in the city.
Marquee Sydney is the third nightclub to join the family after the famed Marquee New York and Marquee Las Vegas. The award-winning nightclubs have built an undisputed reputation as the venue of choice for music lovers and celebrities alike, with an unbeaten line up of local and international artists week after week. Pre-sale ticket purchases are strongly recommended to avoid capacity issues and ensure express entry. Entry is subject to capacity, dress code and management reserves the right of entry. A current Australian driver's license or passport is required. Identification must be valid (not expired).


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Kyle Busch wins Denny Hamlin's Short Track Showdown for 3rd time in 6 years
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RICHMOND, Va. – Kyle Busch has won Denny Hamlin's Short Track Showdown for the third time in six years.
Busch, a teammate of Hamlin's with Joe Gibbs Racing, grabbed the lead before the 5-minute pit stops that came after 46 laps, then pulled away when the race went back to green, easily holding off David Ragan on Thursday night.
With Hamlin sidelined by a compression fracture of a vertebra in his lower back and forced to watch the event at his home track, Busch once again made the 75-lap race his to lose in a car that was built by his team, Kyle Busch Motorsports.
Ragan was second, and Ben Rhodes finished third.
The race benefits the Denny Hamlin Foundation, which is committed to helping children with cystic fibrosis.


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Born in Walla Walla, Washington and raised in Seattle, 40-year-old Brad Shepik began playing guitar at age 10, when he picked up his father's instrument. He continued to play both guitar and saxophone in school bands and studied guitar with Al Galante. He earned a B.F.A from Cornish College of the Arts and a Masters in Jazz Performance/Composition from New York University.
Since arriving in New York in 1990, Shepik has been involved several ensembles including the Tiny Bell Trio, Paradox Trio, Pachora, and BABKAS. He has also performed with Carla Bley, Charlie Haden and toured and recorded with Paul Motian's Electric Bebop Band for 5 years. Concurrently, the guitarist extended his knowledge of world music idioms by performing and recording in such groups as Yuri Yunakov's Bulgarian Wedding Band and Simon Shaheen's Quantara. Shepik's first two records as a leader, The Loan and The Well, were praised for their marriage of world music styles and jazz.
Shepik also co-led two world music tinged trios: Triduga with accordionist Yuri Lemeshev and Tony Scherr on bass balalaika, and Lingua Franca with Peter Epstein and Matt Kilmer. In 2000, Shepik began exploring the traditional guitar/bass/drums format with drummer Tom Rainey and bassist Scott Colley. They recorded two CDs, Drip and ShortTrip, both of which were critically acclaimed and featured on NPR.
Shepik's current working band is a trio with Gary Versace, organ and Rainey, drums. The band has performed at festivals across Europe and North America. Their latest release, Places You Go, received a 4 star review in Down Beat, and appeared on several "Best CDs of 2007" lists. Shepik also continues to tour with drummer Joey Baron's Killer Joey, udist/violinist Simon Shaheen, George Schuller, Matt Darriau's Paradox Trio, Alexis Cuadrado Puzzles Quartet, Arthur Kell Quartet, Combo Nuvo, Bob Brookmeyer's Quartet East and others. Shepik was featured on NEC Jazz Chair Ken Schaphorst's 1999 Big Band recording, Purple.
Currently Shepik is writing a 12 part suite for jazz quintet titled "Human Activity -Sounding a Response to Climate Change." The piece will be premiered June 2008 in New York.
B.F.A, Cornish College of the Arts. Masters in Jazz Performance/Composition, New York University; Studies with Gil Goldstein, George Garzone, Marc Consoli, Jerry Granelli, Julian Priester, Dave Petersen, Dave Peck, James Knapp and Ralph Towner. Former faculty of The New School, City College, Long Island College, New York University.
Photo by Andrew Hurlbut


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DS Ethan 12/16/2008
Breast fed/pumped 11 months as a surgical resident, 80 hours a week at work
DS Abram Daniel 12/20/2012
Feel like we've gotten a strong start
Thank you for your replies.
The issue is that he is not averaging 24 oz a day. Yesterday he only took in around 20 oz on his own and we supplemented 5 oz. Maybe this is the best that we can do. I'd love to get back to EBF but I don't know how to get off these supplements other than waking him up in the night to eat. He usually sleeps from 11pm to 7:30am. I guess I just have to keep trying to feed him more often.
Have you tried dreamfeeding? My daughter feeds really well while asleep. You might try scooping baby up and bringing him into nursing position - he may latch right on and nurse without you needing to wake him. That's a long stretch at night - you could easily get a few ounces in that way. Just an idea!
Way too lazy for formula
Yes, I remember you saying that.
We gave him the supplement at most of the feeds when he took less than 3 oz. So it was 4 feeds, with 1-2 oz. One feed he only transferred 1 oz.
He ate only 8 times yesterday, which I know should be more. We're trying our best to feed as often as we can, but I know we can do better.
OK. So how often did you pump yesterday?
Way too lazy for formula
I pumped 3 times yesterday. After his morning feed, once in the afternoon and before going to bed.
??? You pumped AFTER he got 6oz off you?
Way too lazy for formula
Yup, 4.5 oz. It's an easy time for me to get his supplement oz.
It seems like he is only able to get a large amount of oz out of me when I'm engorged. Too bad I can't be engorged all the time. Ha.
This morning he ate 4.5 oz and I pumped 6 oz.


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Java 1A Practical Class
Table of Contents
Last week you applied some basic software design principles to your program. You used an interface to provide abstraction, allowing several alternative storage implementations to be written and easily substituted for one another. In addition, you used inheritance to share code between those implementations. This week you are going build your own graphical interface with Java Swing in order to make your program more accessible to other users.
You may find Sun's Swing Tutorial helpful:
Remember to check the course website regularly for announcements and errata:
Java Swing is a graphical user interface supported by the Java standard library which supports a vast range of graphical components. Components include widgets such as buttons, menus and text boxes, as well as containers which may contain (and control the layout) of any widgets or containers within them. Because containers may themselves contain containers, a typical graphical interface in Swing is built by recursively nesting containers and widgets. You will use this technique in this workbook to layout a graphical interface for the Game of Life.
To create a new Swing application you will need to create a window to display your graphical components. A window in Swing is created by creating an instance of
JFrame. Here is a simple example:
package uk.ac.cam.crsid.tick6; import javax.swing.JFrame; import javax.swing.JLabel; public class HelloSwingWorld extends JFrame { HelloSwingWorld() { super("Hello Swing"); //create window & set title text setDefaultCloseOperation(EXIT_ON_CLOSE); //close button on window quits app. JLabel text = new JLabel("Hello Swing"); //create graphical text label add(text); //associate "text" with window setSize(320,240); //set size of window } public static void main(String[] args) { HelloSwingWorld hello = new HelloSwingWorld(); //create instance hello.setVisible(true); //display window to user } }
As you can see, writing a basic graphical interface is quite simple. The
import statements tell Java that the definitions of
JFrame and
JLabel are inside the package
javax.swing. You might like to look at the documentation for these widgets in the Java documentation.
In the example above,
HelloSwingWorld extends
JFrame to create a new window. The use of inheritance used here, whilst optional, is convenient since it makes it easy to invoke the methods
setSize and
An instance of
JLabel represents a string on the graphical interface; note however that the
add method must be called to attach the instance called
text to the instance of
HelloSwingWorld created in the constructor. The
setSize operator configures the default size of the window when it is created, although the user can change the size at run-time (try resizing the window yourself to see what happens). Finally,
setVisible is called to display the window to the user; if you forget to call
setVisible with the argument
true, your graphical interface will not be displayed and your program will terminate instead.
In order to create more complicated graphical interfaces, you will need to tell Swing how to layout the elements in the window. In order to get a visual impression of the layout options, take a look at the layouts described in the Swing tutorial: http://java.sun.com/docs/books/tutorial/uiswing/layout/visual.html. You do not need to work through the tutorial now, although you might like to look at it if you get stuck or you want to know more. There are eight layout types:
GroupLayout and
In order to create a graphical interface for the Game of Life, the screen should be divided up as shown in Figure 1, "Layout of GUI for the Game of Life; the left shows the GUI, and the right shows the names of the main interface containers". Controlling the size of each of the components as the window is resized is important: the window should make good use of the display area whatever the size of the window. It is a bad idea to assume that the window is of a fixed size, since the size of screens varies between computers, and some users may prefer the window to occupy only a portion of the desktop in order to view multiple applications simultaneously. The decision of how best to use the space available in the window is application specific.
Figure 1. Layout of GUI for the Game of Life; the left shows the GUI, and the right shows the names of the main interface containers
When resizing the graphical interface for the Game of Life, the main window should grow or shrink the Game Panel depending on the space available; in contrast the size of the Options Panel should remain fixed. The Options Panel (which contains the Source Panel, Pattern Panel, and Control Panel) should take up only the space which is necessary to display the widgets within it. This kind of control over resizing can be achieved using
BorderLayout. Below is an example program which demonstrates how to use this layout type.
package uk.ac.cam.crsid.tick6; import java.awt.BorderLayout; import java.awt.Color; import javax.swing.JFrame; import javax.swing.JPanel; public class GuiLife extends JFrame { public GuiLife() { super("Coloured Boxes"); setSize(640,480); setDefaultCloseOperation(EXIT_ON_CLOSE); setLayout(new BorderLayout()); JPanel optionsPanel = createOptionsPanel(); add(optionsPanel,BorderLayout.WEST); JPanel gamePanel = createGamePanel(); add(gamePanel,BorderLayout.CENTER); } private JPanel createOptionsPanel() { //TODO } private JPanel createGamePanel() { JPanel result = new JPanel(); result.setBackground(Color.GREEN); return result; } public static void main(String[] args) { GuiLife gui = new GuiLife(); gui.setVisible(true); } }
If you run the program
GuiLife and resize the window, you should find that the green area (a placeholder for the Game Panel) takes up all the additional space made available through expanding the size of the window, and the size of the blue area (a placeholder for the Options Panel) remains fixed. This is just the behaviour required for the graphical interface for the Game of Life. The window behaves in this way because the behaviour of
BorderLayout is to resize the "center" panel in preference to any other panels which might exist.
In the previous section you created a window which used
BorderLayout to control the layout of the window. We will now add further components to the Options Panel to hold the Source Panel, Pattern Panel and Control Panel. Below is a program which, when completed, will create space for all the key parts of our graphical interface.
package uk.ac.cam.crsid.tick6; import java.awt.BorderLayout; import javax.swing.border.Border; import javax.swing.BorderFactory; import javax.swing.Box; import javax.swing.JComponent; import javax.swing.JFrame; import javax.swing.JPanel; import javax.swing.JScrollPane; import javax.swing.border.EtchedBorder; public class GuiLife extends JFrame { public GuiLife() { super("GuiLife"); setSize(640, 480); setDefaultCloseOperation(EXIT_ON_CLOSE); setLayout(new BorderLayout()); JComponent optionsPanel = createOptionsPanel(); add(optionsPanel, BorderLayout.WEST); JComponent gamePanel = createGamePanel(); add(gamePanel, BorderLayout.CENTER); } private JComponent createOptionsPanel() { Box result = Box.createVerticalBox(); result.add(createSourcePanel()); result.add(createPatternPanel()); result.add(createControlPanel()); return result; } private void addBorder(JComponent component, String title) { Border etch = BorderFactory.createEtchedBorder(EtchedBorder.LOWERED); Border tb = BorderFactory.createTitledBorder(etch,title); component.setBorder(tb); } private JComponent createGamePanel() { JPanel holder = new JPanel(); addBorder(holder,Strings.PANEL_GAMEVIEW); JPanel result = new JPanel(); holder.add(result); return new JScrollPane(holder); } private JComponent createSourcePanel() { JPanel result = new JPanel(); addBorder(result,Strings.PANEL_SOURCE); return result; } private JComponent createPatternPanel() { /*TODO*/ } private JComponent createControlPanel() { /*TODO*/ } public static void main(String[] args) { GuiLife gui = new GuiLife(); gui.setVisible(true); } }
In the example program, the Options Panel is created as a container with a vertical
BoxLayout layout; such a component places all the components within itself vertically. The layout of widgets inside a container such as the Options Panel is quite flexible in Swing. Widgets have three sets of dimensions: a minimum size, a preferred size, and a maximum size. In the case of a vertical
BoxLayout as used in the Options Panel, Swing attempts to provide space for widgets at their preferred size. More information on the resizing of widgets using a particular layout with Swing can be found in Sun's documentation for the appropriate layout class.
In the example above, you may have noticed there is a new object called
Strings. This is in fact another class in the same package as
GuiLife which contains all of the text data used in the graphical interface. It's a good idea to collect together all the strings used in the interface in one place so that they are easy to modify; this is especially useful if you wish to update the application so that it supports multiple languages. The contents of
Strings should be as follows:
package uk.ac.cam.crsid.tick6; public class Strings { public static final String PANEL_SOURCE = "Source"; public static final String PANEL_PATTERN = "Starting pattern"; public static final String PANEL_CONTROL = "Control"; public static final String PANEL_GAMEVIEW = "Game State"; }
In the previous section, you created space for the four main elements of the final graphical display. In this section you will complete the body of the Source Panel. The Source Panel will eventually allow the user to select the source of the patterns for the initial state of the world. Possible sources could include a file in the file system, or a URL. This week you will add support for four possible input methods on the display, none of which will actually function! Next week you will implement the code to make them work.
In your application you will only ever have one source at a time, and therefore a user interface component which only allows the user to select a single source is required. One such user interface component is the Radio Button which provides the user with a selection from one of several alternatives.
To use a Radio Button in your implementation of Source Panel you should create a separate class to contain the details of the widgets used. Below is a partially complete implementation of
SourcePanel which uses
JRadioButton widgets to control user selection of the source of patterns for the Game of Life.
package uk.ac.cam.crsid.tick6; //TODO: specify the appropriate import statements public class SourcePanel extends JPanel { public SourcePanel() { super(); setLayout(new BoxLayout(this,BoxLayout.X_AXIS)); JRadioButton none = new JRadioButton(Strings.BUTTON_SOURCE_NONE, true); JRadioButton file = new JRadioButton(Strings.BUTTON_SOURCE_FILE, true); JRadioButton library = new JRadioButton(Strings.BUTTON_SOURCE_LIBRARY, true); JRadioButton fourStar = new JRadioButton(Strings.BUTTON_SOURCE_FOURSTAR, true); //add RadioButtons to this JPanel add(none); add(file); add(library); add(fourStar); //create a ButtonGroup containing all four buttons //Only one Button in a ButtonGroup can be selected at once ButtonGroup group = new ButtonGroup(); group.add(none); group.add(file); group.add(library); group.add(fourStar); } }
The class
SourcePanel extends
JPanel, creating a new interface component which you can add to an existing
JFrame or
JComponent. The constructor for
SourcePanel first calls the default constructor of the super class, and then configures the layout for this component as a
BoxLayout with components laid horizontally. Four new instances of
RadioButton are created, and these are then added to the current instance of
SourcePanel under construction using the
add method supplied by the parent class. The remainder of the constructor creates a new instance of
ButtonGroup and then adds the instances of
JRadioButton to it;
ButtonGroup prevents more than one
JRadioButton instance in the group from being selected at the same time.
In this section you will load a list of patterns into the Pattern Panel. To do so, you will need to use the
JList object to contain the list of patterns. The
JList component should be placed inside a
JScrollPane, which adds scroll bars to the list; this is required since the number of patterns may be quite large and you will not want the window to grow too large. Here is an outline of the code needed to implement the Pattern Panel:
package uk.ac.cam.crsid.tick6; //TODO: specify the appropriate import statements public class PatternPanel extends JPanel { private JList guiList; public PatternPanel() { super(); setLayout(new BorderLayout()); guiList = new JList(); add(new JScrollPane(guiList)); } public void setPatterns(List<Pattern> list) { ArrayList<String> names = new ArrayList<String>(); //TODO: Using a for loop which iterates over the items // in "list" and adds the pattern name and pattern // author to "names". For example, if the pattern // name and author is "Glider" and "Richard Guy 1970" // then you should add the string: // // "Glider (Richard Guy 1970)" // // to "names" using the method "add" on "names". guiList.setListData(names.toArray()); } }
The Control Panel part of the interface shown in Figure 1 looks quite complex. The method of laying out the elements you should use is to create a vertical
BoxLayout inside the Control Panel with four elements, each element of which contains a horizontal
BoxLayout; the first, second and third inner horizontal
BoxLayout objects will contain a
JLabel object followed by a
JSlider object. The last element is a
JLabel followed by a group of three
JRadioButton objects. It's perhaps best to view this layout visually by looking back to Figure 1 and then reading the code which lays out the Control Panel as just described:
//TODO: Write a suitable package statement and import statements public class ControlPanel extends JPanel { private JSlider zoomSlider; private JSlider stepSlider; private JSlider speedSlider; private JRadioButton longButton; private JRadioButton arrayButton; private JRadioButton agingButton; private JSlider createNewSlider(int min, int max, int start, String s) { Box panel = Box.createHorizontalBox(); add(panel); panel.add(new JLabel(s)); JSlider slider = new JSlider(min,max,start); panel.add(slider); return slider; } private JRadioButton createNewButton(String s, ButtonGroup g, Box b) { //TODO: create a new instance of JRadioButton with text "s" //TODO: add the new instance to the ButtonGroup referenced by "g" //TODO: add the new instance to Box "b" //TODO: return a reference to the new instance }
public ControlPanel() { super(); setLayout(new BoxLayout(this,BoxLayout.Y_AXIS)); zoomSlider = createNewSlider(1,20,1,Strings.CONTROL_ZOOM); add(Box.createVerticalStrut(10)); //add 10px of extra space stepSlider = createNewSlider(1,10,1,Strings.CONTROL_STEP); add(Box.createVerticalStrut(10)); //add 10px of extra space speedSlider = createNewSlider(0,100,0,Strings.CONTROL_SPEED); add(Box.createVerticalStrut(10)); //add 10px of extra space Box worldPanel = Box.createHorizontalBox(); add(worldPanel); worldPanel.add(new JLabel(Strings.STORAGE_WORLD_TYPE)); ButtonGroup group = new ButtonGroup(); longButton = createNewButton(Strings.STORAGE_LONG,group,worldPanel); arrayButton = createNewButton(Strings.STORAGE_ARRAY,group,worldPanel); agingButton = createNewButton(Strings.STORAGE_AGING,group,worldPanel); arrayButton.setSelected(true); add(Box.createVerticalStrut(10)); //add 10px of extra space } public World initialiseWorld(Pattern p) throws PatternFormatException { World result = null; if (longButton.isSelected()) { result = new PackedWorld(); } else if (arrayButton.isSelected()) { result = new ArrayWorld(p.getWidth(),p.getHeight()); } else if (agingButton.isSelected()) { result = new AgingWorld(p.getWidth(),p.getHeight()); } if (result != null) p.initialise(result); return result; } }
The Game Panel should display the state of the game board. The code for the Game Panel is:
//TODO: Write a suitable package statement and import statements public class GamePanel extends JPanel { private int zoom = 10; //Number of pixels used to represent a cell private int width = 1; //Width of game board in pixels private int height = 1;//Height of game board in pixels private World current = null; public Dimension getPreferredSize() { return new Dimension(width, height); } protected void paintComponent(Graphics g) { if (current == null) return; g.setColor(java.awt.Color.WHITE); g.fillRect(0, 0, width, height); current.draw(g, width, height); if (zoom > 4) { g.setColor(java.awt.Color.LIGHT_GRAY); //TODO: Using for loops call the drawLine method on "g", // repeatedly to draw a grid of grey lines to delimit // the border of the cells in the game board } } private void computeSize() { if (current == null) return; int newWidth = current.getWidth() * zoom; int newHeight = current.getHeight() * zoom; if (newWidth != width || newHeight != height) { width = newWidth; height = newHeight; revalidate(); //trigger the GamePanel to re-layout its components } } public void display(World w) { current = w; computeSize(); repaint(); } }
The work described in this section is optional; you may skip the work described here and proceed directly to the last section of the Workbook. In the previous sections, you have displayed all the widgets needed to support a graphical interface for the Game of Life. Unfortunately none of the widgets actually do anything! For example, changing the zoom slider does not actually change the zoom level of the Game Panel. Next week we will investigate how to support event handlers in Java to update parts of the program in response for user input and make the graphical interface fully functional.
This week you will finish your implementation by adapting code from the
main method you wrote for
RefactorLife last week. The code you wrote last week parsed options, a URL or file, and an integer the user provided to the program on the command line. Many of you produced a somewhat lengthy and messy implementation! A better solution is to create a new class to store the pertinent details provided by the user on the command line. Here is a skeleton structure of such a class:
package uk.ac.cam.crsid.tick6; public class CommandLineOptions { public static String WORLD_TYPE_LONG = "--long"; public static String WORLD_TYPE_AGING = "--aging"; public static String WORLD_TYPE_ARRAY = "--array"; private String worldType = null; private Integer index = null; private String source = null; public CommandLineOptions(String[] args) throws CommandLineException { //TODO: parse "args" to update the private fields "worldType", // "index" and "source" with the correct values, if any. } public String getWorldType() {return worldType;} public Integer getIndex() {return index;} public String getSource() {return source;} }
Notice that the constructor for
CommandLineOptions may throw an exception of type
CommandLineException, which you should define as follows:
package uk.ac.cam.crsid.tick6; public class CommandLineException extends Exception { public CommandLineException(String message) { super(message); } }
In the constructor of
CommandLineException you should pass in a message of type
String. Since
CommandLineException inherits from
Exception you can retrieve the message using the
getMessage method on
CommandLineException. You will find the following implementation of
TextLife helpful in writing and testing your implementation of
//TODO: Write a suitable package statement and import statements public class TextLife { public static void main(String[] args) { CommandLineOptions c = new CommandLineOptions(args); List<Pattern> list; if (c.getSource().startsWith("http://")) list = PatternLoader.loadFromURL(c.getSource()); else list = PatternLoader.loadFromDisk(c.getSource()); if (c.getIndex() == null) { int i = 0; for (Pattern p : list) System.out.println((i++)+" "+p.getName()+" "+p.getAuthor()); } else { Pattern p = list.get(c.getIndex()); World w = null; if (c.getWorldType().equals(CommandLineOptions.WORLD_TYPE_AGING)) { w = new AgingWorld(p.getWidth(), p.getHeight()); } else if (c.getWorldType().equals(CommandLineOptions.WORLD_TYPE_ARRAY)) { w = new ArrayWorld(p.getWidth(), p.getHeight()); } else { w = new PackedWorld(); } p.initialise(w); int userResponse = 0; while (userResponse != 'q') { w.print(new OutputStreamWriter(System.out)); try { userResponse = System.in.read(); } catch (IOException e) {} w = w.nextGeneration(0); } } } }
The class
TextLife uses many of the classes you wrote in previous weeks; you should have already copied across the relevant classes to successfully complete previous exercises found in this workbook. You should use the class
TextLife above to help you test your implementation of
CommandLineOptions. For example,
TextLife should function as shown in the following examples:
crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife Error: No arguments found crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife \ http://www.cl.cam.ac.uk/teaching/current/ProgJava/life.txt | head -n 2 0 Glider Richard Guy 1970 1 Blinkers Horton Conway 1970 crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife \ http://www.cl.cam.ac.uk/teaching/current/ProgJava/life.txt -3 Error: Index out of bounds crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife \ --long http://www.cl.cam.ac.uk/teaching/current/ProgJava/life.txt | head -n 2 0 Glider Richard Guy 1970 1 Blinkers Horton Conway 1970 crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife \ http://www.cl.cam.ac.uk/teaching/current/ProgJava/life.txt 0 - ________ ___#____ _#_#____ __##____ ________ ________ ________ ________ q crsid@machine:~> java -cp world.jar:. uk/ac/cam/crsid/tick6/TextLife \ --aging http://www.cl.cam.ac.uk/teaching/current/ProgJava/life.txt 0 ________ ___#____ _#_#____ __##____ ________ ________ ________ ________ - ________ __#1____ _1_##___ __##____ ________ ________ ________ ________
To complete your tick you need to prepare a jar file with the contents of all the classes you have written in this workbook and email it to
email@example.com. Your jar file should contain:
uk/ac/cam/crsid/tick6/HelloSwingWorld.java uk/ac/cam/crsid/tick6/HelloSwingWorld.class uk/ac/cam/crsid/tick6/CommandLineOptions.java <-- optional uk/ac/cam/crsid/tick6/CommandLineOptions.class <-- optional uk/ac/cam/crsid/tick6/TextLife.java <-- optional uk/ac/cam/crsid/tick6/TextLife.class <-- optional uk/ac/cam/crsid/tick6/GuiLife.java uk/ac/cam/crsid/tick6/GuiLife.class uk/ac/cam/crsid/tick6/GamePanel.java uk/ac/cam/crsid/tick6/GamePanel.class uk/ac/cam/crsid/tick6/Strings.java uk/ac/cam/crsid/tick6/Strings.class uk/ac/cam/crsid/tick6/ControlPanel.java uk/ac/cam/crsid/tick6/ControlPanel.class uk/ac/cam/crsid/tick6/PatternPanel.java uk/ac/cam/crsid/tick6/PatternPanel.class uk/ac/cam/crsid/tick6/SourcePanel.java uk/ac/cam/crsid/tick6/SourcePanel.class uk/ac/cam/crsid/tick6/WorldImpl.java uk/ac/cam/crsid/tick6/WorldImpl.class uk/ac/cam/crsid/tick6/ArrayWorld.java uk/ac/cam/crsid/tick6/ArrayWorld.class uk/ac/cam/crsid/tick6/PackedWorld.java uk/ac/cam/crsid/tick6/PackedWorld.class uk/ac/cam/crsid/tick6/AgingWorld.java uk/ac/cam/crsid/tick6/AgingWorld.class uk/ac/cam/crsid/tick6/Pattern.java uk/ac/cam/crsid/tick6/Pattern.class uk/ac/cam/crsid/tick6/PackedLong.java uk/ac/cam/crsid/tick6/PackedLong.class uk/ac/cam/crsid/tick6/PatternLoader.java uk/ac/cam/crsid/tick6/PatternLoader.class uk/ac/cam/crsid/tick6/PatternFormatException.java uk/ac/cam/crsid/tick6/PatternFormatException.class
If you completed the optional work, you should be able to run your program in one of three ways:
java -cp world.jar:crsid-tick6.jar \
uk.ac.cam.crsid.tick6.TextLife [url/file]
java -cp world.jar:crsid-tick6.jar \
uk.ac.cam.crsid.tick6.TextLife [url/file] [index]
java -cp world.jar:crsid-tick6.jar \
uk.ac.cam.crsid.tick6.TextLife [worldType] [url/file] [index]


text:
Covering most of the northern part of the North American continent and with an area larger than that of the United States, Canada has an extremely varied topography. In the east, the mountainous maritime provinces have an irregular coastline on the Gulf of St. Lawrence and the Atlantic. The St. Lawrence plain, covering most of southern Quebec and Ontario, and the interior continental plain, covering southern Manitoba and Saskatchewan and most of Alberta, are the principal cultivable areas. They are separated by a forested plateau rising from Lakes Superior and Huron.
Westward toward the Pacific, most of British Columbia, the Yukon, and part of western Alberta are covered by parallel mountain ranges, including the Rockies. The Pacific border of the coast range is ragged with fjords and channels. The highest point in Canada is Mount Logan (19,850 ft; 6,050 m), which is in the Yukon. The two principal river systems are the Mackenzie and the St. Lawrence. The St. Lawrence, with its tributaries, is navigable for over 1,900 mi (3,058 km).
Canada is a federation of ten provinces (Alberta, British Columbia, Manitoba, New Brunswick, Newfoundland and Labrador, Nova Scotia, Ontario, Prince Edward Island, Quebec, and Saskatchewan) and three territories (Northwest Territories, Yukon, and Nunavut). Formally considered a constitutional monarchy, Canada is governed by its own House of Commons. While the governor-general is officially the representative of Queen Elizabeth II, in reality the governor-general acts only on the advice of the Canadian prime minister.
The first inhabitants of Canada were native Indian peoples, primarily the Inuit (Eskimo). The Norse explorer Leif Eriksson probably reached the shores of Canada (Labrador or Nova Scotia) in 1000, but the history of the white man in the country actually began in 1497, when John Cabot, an Italian in the service of Henry VII of England, reached Newfoundland or Nova Scotia. Canada was taken for France in 1534 by Jacques Cartier. The actual settlement of New France, as it was then called, began in 1604 at Port Royal in what is now Nova Scotia; in 1608, Quebec was founded. France's colonization efforts were not very successful, but French explorers by the end of the 17th century had penetrated beyond the Great Lakes to the western prairies and south along the Mississippi to the Gulf of Mexico. Meanwhile, the English Hudson's Bay Company had been established in 1670. Because of the valuable fisheries and fur trade, a conflict developed between the French and English; in 1713, Newfoundland, Hudson Bay, and Nova Scotia (Acadia) were lost to England. During the Seven Years' War (1756–1763), England extended its conquest, and the British general James Wolfe won his famous victory over Gen. Louis Montcalm outside Quebec on Sept. 13, 1759. The Treaty of Paris in 1763 gave England control.


text:
lucash needed a new logo design and created a contest on 99designs.
A winner was selected from 145 designs submitted by 46 freelance designers.
I am going to end the contest tonight, because I will leave for a short vacation break. I will pick the winning design around 9 PM CET. Thanks for all your submissions so far!
We started a company the customers and projects are there. But we still haven't got a proper logo design.
I will comment a lot on the designs and if possible, contact desingers that I like for future work for clients. We need a smart, cool, clever, clean and awesome logo that we can use with a lot of proud!
Like to hear/see from you!
magicLabs or magiclabs
magiclabs will help project with all sort of IT-related projects. From creating an advanced webshop or website to generating a smashing business film. We are capable of it, because we are using our contact, all over the world. From India to the US from Indonesia to Holland.
if other questions or sample you can ping me at skype @ lucas.huizinga
- Logo with good typography
- nice icon that reflects the businessname
- Look like an unique, high quality brand
- Logo that is so good, it can be featured at logopond
- Logo on businesscard will be printed in silver-color, so logo must look good in mono color
- Offcourse, after finishing a vector file
- guess not needed..
Find out how a design contest works or learn more about our logo design services.


text:
Separate names with a comma.
Discussion in 'iPhone' started by iThink Apple, Sep 16, 2012.
Mine is preparing for shipment!! Maybe I see a tracking number Monday?
Mine has shipped via ups from china. Ordered from apple. Tracking found on ups.com, track by reference and use your phone number.
That didn't work for me.....
I wouldn't worry, one of my other orders hasn't shown up yet either. I would try later this evening.
Thanks! I tried this and was able to see that mine has shipped as well, and I was able to get the tracking number.
Last Location:
Departed - ZhengZhou, China, Sunday, 09/16/2012
Mine's preparing for shipment too. How do you know what courier will be used?
The phone number I ordered the phone on or the phone number associated with my apple account?
You really don't at this point, but just try ups and tracking by reference number
I believe apple account
Still 'preparing for shipment'
THey are shipping!!!
Ups.com click track
click track by refernce
enter your billing phone number and zip code!
Yahoo I have my tracking info!
Anyone know info on tracking the planes?
Since Fedex ships faster, I think East coast and Central customers will receive their phones from them. Leaving Mountain time and West coast customers with UPS.
I've had 'preparing for shipment' for 4 different i5's since yesterday.
Can confirm because the UPS method doesn't work for me.
Edit: UPS worked for me a few days ago for my iPhone but my parents and girlfriend still cannot track theirs.
With the 4 and 4s, those that shipped from China via UPS were set for 10:30 AM delivery.
Same here, i'm pumped for Friday.
A buddy of mine is going to go into Best Buy to try to pre-order and pick it up on Friday.... the poor fool.
I think Fedex was the same tbh
I live in New Hampshire and my info is on ups.com
Just pure speculation on my part. How far is your iPhone in the shipping process?
Maybe a lot of people will get their phones on Thursday.
Still processing...
Ordered at 3:18 am EST on the 14th
i didnt pre order either but i'm not using best buy rather the apple store 5 minutes from my house..pretty sure i will have mine before you will
No. Ups didnt work. No worries.
Last Location:
Arrived - ZhengZhou, China, Sunday, 09/16/2012
20 min ago it said departed from that same location. Maybe it left some sorting facility and now is getting ready to be shipped on the plane.
Found my tracking # by using the "track by reference"! A couple questions though:
1. My UPS delivery guy usually comes here very late in the day like 630p - 700p. Will this change for the iPhone 5 delivery?
2. It says that the scheduled delivery date is 9/21, will it say that for orders that might have to come early? Does anyone have experience with early delivery for iphone 4 or 4s that could confirm this?
I'm so excited!!!!!!!!!!!!!!!!!!! Been waiting for LTE for 2 years and I'm the last one of my friends to get a LTE phone.
The only way it will come early is if it says Early AM delivery on it or if they run different routes that day
Same status here, delivery in VA- FYI
Where would I find "Early AM delivery" on the tracking page?
No info from either shipper yet ordered 3:07AM 9/14


text:
When we make a big purchase like a car, furniture or home appliance, we tend to take the time to research the item.
To ensure we get the best deal, we will visit several stores and go online to find the best price available.
Unfortunately, most people overlook the one thing that makes a significant impact on their finances - groceries.
Groceries are something that we must buy consistently, but when it comes to time to shop, we often don't do enough research on them.
Shoppers just head to the store and fill their shopping carts with items they want and need.
They don't even take the time to look at the price of the item. Shopping like this will cost you tons over a lifetime.
Take a look at what you spend on groceries. Count what you spend on take-out foods and dinners at your favorite restaurants.
You'll be amazed.
One of my economics teachers once asked us how much money we should budget for food. He laughed when I replied $400. He wanted to know if I ate beans and rice every day.
I replied, "No sir, I eat steak, chicken, pork and just about anything else that I want to. I'm just smart about what, where and when I purchase those items."
I find it ironic that 20 years later, I am teaching thousands how to reduce their grocery budgets.
Here are five things you can do now to start reducing your grocery bill:
1. Give up brand loyalty. The store brand is sometimes better than the national brand. However, when I use coupons, the name brand is often cheaper than the store brand.
2. Review the weekly sales. You will want to pick up the Wednesday, Thursday and Sunday papers to receive all the grocery store ads before you go shopping.
3. Check out my blog. Go to www.savannahnow.com/savvyshopper for the best deals of the week.
4. "Like" us. At the Savannah Savvy Shopper Facebook page, www.facebook.com/savannahsavvyshopper, you will find many useful posts from savvy shoppers throughout the area with info on markdowns on grocery items.
5. Plan ahead. A weekly menu based on what you already have and what is on sale will save you time and money.
Send your tips or questions to Savvy Shopper Michelle Rubrecht at firstname.lastname@example.com. Sign up for her next Couponing 101 classes at 6:30 p.m. Feb. 21 at the Savannah Morning News, 1375 Chatham Parkway. The fee is $5 online or at the door. Register at savannahnow.com/events.


text:
Skip to comments.Massive terror exercise planned for metro area
Posted on 09/22/2011 3:52:47 PM PDT by Momaw Nadon
Operation Mountain Guardian is a terrorism-based, full-scale emergency exercise scheduled to take place in numerous locations in the Denver metro area on Friday, September 23, 2011.
The exercise will involve first responders from 81 different agencies**, will be conducted at ten separate locations and will include loud noises, simulated weapons, smoke, emergency vehicles and other equipment that will be audible and visible throughout the day.
The purpose of this advisory is to provide information that can be disseminated to the public ahead of time to avoid confusion or concern on exercise day, as well as to invite media coverage of the event.
* Operation Mountain Guardian will be held at the following locations throughout the Denver Metropolitan area:
Primary Locations
1. Park Meadows Mall 2. Smedley Elementary School 3. Denver Union Station 4. Community College of Aurora (Lowry Campus)
Secondary Locations
1. Denver International Airport 2. Sky Ridge Medical Center 3. Denver Health Medical Center 4. University of Colorado Hospital 5. Catholic Charities (NW Denver) 6. Sports Authority Field at Mile High
* A Public Information Officer will be available at each primary location to coordinate safe access for media representatives and provide information. A Denver Joint Information Center PIO will also be available at 720-865-7695.
o MEDIA: Please contact the Joint Information Center or on site PIO for inquiries related to this exercise (not individual agencies). Media inquiries not associated with this event should continue to be directed to the appropriate agency.
* The exercise has been designed as a learning event for regional first responders to test their capabilities in a scenario that will involve a terrorist-driven catastrophic situation. Exercise play will occur at the four primary sites and DIA. Catholic Charities and Sports Authority Field at Mile High will participate in an administrative fashion to test student/teacher processing activities. Sky Ridge Medical Center, Denver Health Medical Center, and University of Colorado Hospital will participate for the purpose of testing medical surge capabilities and communicating within Incident Command.
* The exercise is scheduled to begin at 0500 hours and end by 1630 hours.
* Operation Mountain Guardian is a terrorism-based full-scale exercise sponsored by the North Central All-Hazards Emergency Management Region, Denver Urban Area Security Initiative, and Front Range Metropolitan Medical Response System. The exercise is a Homeland Security Grant funded event made possible due to grant funding from the Department of Homeland Security (DHS) through FEMA Region VIII and the State of Colorado Governors Office of Homeland Security.
* The North Central All-Hazards Emergency Management Region is one of nine emergency preparedness and response Regions within the State of Colorado. The North Central Region (NCR) is organized around ten counties: Adams, Arapahoe, Boulder, Broomfield, Clear Creek, Denver, Douglas, Elbert, Gilpin and Jefferson.
* One purpose of the NCR is to improve Region-wide emergency preparedness, response and homeland security capabilities through coordinated planning, training and exercise efforts. This exercise is evidence of the growing public safety partnership between regional emergency response agencies.
* Operation Mountain Guardian is part of a Regional Training and Exercise Plan established in 2009. Planning for Operation Mountain Guardian began in January 2010 and has included several building-block events designed to prepare responders to effectively participate in the full-scale exercise.
* The overall Operation Mountain Guardian exercise objectives are:
1. Communications: Assess the ability to establish and maintain multi-agency and multi-jurisdictional communications in response to a terrorism incident.
2. Hazmat Response and Decontamination: Evaluate the capability to coordinate multiple hazmat response teams and assess their ability to perform initial response actions.
3. Public Safety & Security Response: Evaluate the ability to establish scene security and crime scene preservation, coordinate a multi-jurisdictional response, and manage intelligence information in order to mitigate the effects of the event.
4. Explosive Device Response Operations: Evaluate the capability to manage and coordinate explosive device response operations using regional bomb squad teams.
5. Onsite Incident Management: Evaluate the ability to implement the Incident Command System (ICS) and establish multi-jurisdictional command and control.
6. Triage and Pre-Hospital Treatment: Examine the ability of EMS to provide effective pre-hospital emergency medical care in response to a terrorism incident.
7. Medical Surge: Evaluate medical surge capability at area hospitals.
* While Operation Mountain Guardian is primarily a Homeland Security Grant funded exercise, the event will also rely heavily on local government emergency response agencies, military organizations, volunteer organizations as well as local charitable organizations.
2012 practice drills.
I'd hate to get confused and overreact to the mayhem.
OMG, I didn't even notice that!
In the interest of realism, will the exercise include having Obama flown to a golf course or to an expensive out of country resort for a working vacation?
Ping to you
Interesting. Thanks, twistedwrench. Isn't 0bummer going to be in Denver sometime before the end of September? - Wonder if this exercise has anything to do with those alleged secret underground tunnels, although they aren't secret since the graphics are on the 'net.
(Disclaimer: I do not know whether this is a valid graphic, or if a forty-year old guy with a vivid imagination, living in his parent's basement produced it.)
Yep, I think it's the 27th, Part of his Tax the Rich Tour.
Where are the good, old meat wagons (ambulances), each with a couple of fast, strong, young men running them? They could do a better job. And courageous policemen with common sense? If so many people in high places are afraid of "terrorist" attacks, we should have fought and won a war instead of trying to catch Ayrabs red handed in attacks against us.
Operation Mountain Guardian - largest terrorism drill ever takes place in Denver as Obama visits on the 27th. This is when we have a Elenin-Earth-Sun-Merucry alignment happening. Worth keeping an eye on.
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CHATHAM — Even corn flattened by storms looks good for the fall harvest in Illinois.
Barring major changes in conditions in the next eight weeks — and farmers are quick to point out this is the Midwest — potential record corn and soybean crops have begun to mature across the state, and nowhere more so than in central Illinois.
The once unthinkable 300 bushels an acre has been tossed around. All of this two years after the worst drought in decades.
"It's the best grain we've ever had," said Ted Dowson, who has seen harvests good, average and awful in his 76 years. Keeping that experience in mind, Dowson added, "check with me in a couple of months."
Dowson, a member of one of the region's oldest farm families, was among dozens of farmers at a Conklin Co. agricultural field demonstration held Thursday at Sugar Creek United Methodist Church, east of Chatham.
Farmers from across central Illinois and portions of Missouri reported the same ideal mix of rain and temperatures this year, as well as lower corn and soybean prices in anticipation of a major crop in most portions of the country.
"We had ideal planting weather in the beginning. We've had the steady rain we need. This year, we've had cooler temperatures. It hasn't been too hot," said Cathryn Ayers.
She and her brother, Cameron, work with her father, Jimmy, on the family farm. The Ayers family hosted Thursday's event.
Champion grower
Corn yields of 300-bushels-plus per acre are not new for southeast Missouri farmer Jerry Cox. He has won 21 National Corn Growers Association awards for highest yields in a region that includes Minnesota, Missouri, Illinois, Iowa, Indiana, Ohio and Wisconsin.
Cox, a featured speaker at the field day, said he expects to hit 300 bushels again this year in some spots of the 2,000 acres he farms just south of Cape Girardeau. The acreage is about 50-50 corn and soybeans this year.
"It looks like it does here," Cox said of his crop. "I honestly think, for myself, it will be my highest. We still have another month or so to go here, so things could happen."
When it comes to farm income this year, said Cox, the question is whether corn and soybean volume will offset lower prices. Corn for fall delivery has traded below $4 a bushel, which is generally considered the break-even point by agricultural analysts, while soybeans have traded just above $11, considered the difference between profits and losses.
Host farmer Jimmy Ayers said he has heard similar stories from across central Illinois — big yields and questions about prices. But two years after the devastating drought, said Ayers, farmers will take what amounts to ideal conditions in 2014.
"It's a good year," said Ayers, "but July and August are pivotal. We still have to fill in kernels."
Progress report
Another record-holder, Kip Cullers, said soybeans look every bit as good as corn. Cullers has set a series of world records for soybean yields, hitting as high as 161 bushels an acre, on his southeast Missouri farm. Given weather conditions, Cullers said he has another shot this year.
"I think they'll make for some very good yields," said Cullers, who also was a featured speaker at Thursday's field day.
Corn and soybeans in Illinois are in good shape and ahead of schedule, according to a weekly update of crop conditions from the U.S. Department of Agriculture. Farmers surveyed by USDA rated 81 percent of corn and 77 percent of soybeans good to excellent in the report released last week.
There has been isolated field flooding in the state, and thunderstorms flattened thousands of acres of corn in northern Illinois earlier this month.
Even damaged fields have recovered in some cases, said Stan Weber, who farms near the northern Illinois community of Dixon.
"The stalks still have a little curve in them," said Dixon. "I checked some of the ears, and it's hard to tell the damaged corn from the good corn."


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We're fueling up the car, stocking up on munchies, packing in a bunch of giveaways, and heading out on the open roads for our sixth Roadshow! It's also our biggest one yet, as we'll pile on the miles heading to six cities across the northeast:
- Burlington, VT: September 23rd [registration] New Venue
- New City! Albany, NY: September 24th [registration]
- Rochester, NY: September 25th [registration] New Venue
- Augusta, ME: October 3rd [registration] New Venue
- Farmington, CT: October 14th [registration]
- Waltham, MA: October 15th [registration]
[Please note that, in addition to adding Albany, we have new venues in Burlington, Rochester, and Augusta. Details are in the event registration pages, plus a few notes at the bottom of this post.]
Join my fellow road and code warrior, Jim O'Neil and me for a free, relaxed day of deep content for developers and architects. (Roadshow partner Bob Familiar can't make it this time around – he's working on a secret hush-hush type of project – but he'll be back when we return to the roads this winter!)
We're trying out a different kind of session plan this time. We've added a few extra sessions to this series, including topics that fit more comfortably into a smaller amount of time. These "turbo sessions" are a great way to bring a more diverse agenda to you, while staying deep with others. Speaking of the agenda...
8:30 – Registration
9:00 – Understanding the ADO.NET Entity Framework
Abstraction is frequently used to create difficult-to-appreciate artwork, but when applied to software, abstractions can improve flexibility, independence, and the ability to compose higher-level concepts. ADO.NET Entity Framework, now shipping as part of Visual Studio 2008 & .NET 3.5 Service Pack 1, helps you create models of your data that enable a familiar object-oriented programming experience. Entities map flexibly to data sources while providing insulation from schema changes at the same time. LINQ makes an appearance as well, using the familiar syntax we've seen with LINQ to Objects, SQL, and XML to query entities. You've got the picture, so get out there and model some works of art!
10:30 – Discovering Dynamic Data
ASP.NET Dynamic Data, introduced with the .NET Framework 3.5 SP1 release, breathes immediate (i.e., code-less) life into LINQ To SQL and Entity Framework data models by providing a customizable, template-driven, scaffolding framework. Put on your wizard hat, you now have dynamic power at your fingertips.
11:15 - Exploring Internet Explorer 8
Ahoy, developers! The release of Internet Explorer 8 is just around the bend. Of course, we'll pull out the spyglass and take a look over the sea of new consumer features, but what does this next version mean for you as developer, and what should you do to navigate to glory? You'll see how treasures like accelerators and web slices can be a differentiator for your company, see the new wave of compatibility features and options, and unearth the tools available for developers to make for smooth sailing on the sometimes turbulent web development waters.
12:00 – RoboLunch
Grab a lunch and join in as we delve into the world of robotics programming with Microsoft Robotics Developer Studio. Think robotics is mostly for manufacturing systems, toys, and those cool little floor cleaning bots? You may be surprised at how the things we cover may come to affect your professional development life! Perhaps you'll find yourself saying, "Thank you very luncho, Mr. Roboto!"
1:00 - UI, UX, U Confused?
One thing not missing from Microsoft's development offerings is a choice of options. In this session, we'll compare and contrast the various .NET technologies available for building client experiences (Windows Forms, WPF, XBAP, ASP.NET, Silverlight, and Windows Mobile) to give you some insight in to making the best choices for reaching your applications' target audience.
1:45 - A RESTed Development
REST (Representational State Transfer) is what all the cool developers are using these days to communicate among distributed resources and services. So that you're not left standing idly by on the sidelines, we'll look at the rationales of the approach, why it's cleaner than SOAP, and how Microsoft has adopted REST in technologies such as WCF and ADO.NET Data Services.
3:15 - Befriending Unit Testing
Unit testing could be your new best friend, and we're here to help make the proper introductions. A practice that ultimately results in reduced overall efforts, unit testing is a focus on crafting test code that verifies your application code isn't misbehaving. In this session, we'll focus on what unit testing is, how it can be done, and some of the proven and effective practices you can employ to help your unit tests pay dividends over time. If Humphrey Bogart were a developer, he would have agreed, this is the beginning of a beautiful friendship.
4:00 – Wrapup, Giveways, and Bon Voyage!
Thanks very much to Rensselaer Polytechnic Institute for donating use of the Bruggeman Auditorium to enable us to add the Albany area to our list of stops. Sincere thanks as well to KnowledgeWave in Burlington, VT and The Riverview Psychiatric Center in Augusta, ME for donating space in their facilities so we could return to those areas!
We unfortunately couldn't make a visit to our friends at the Rochester Institute of Technology work for this series (though they very helpfully tried), so we're working with the Rochester Public Library for this visit (and not just because they're ridiculously close to Dinosaur BBQ!)
Jim and I can't wait to get out there since we always have a blast with the Roadshows! We'll see you soon!
-Chris and Jim


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MIAMI SHORES, Fla. -- Elisabeth Abanda rallied from a 5-0 deficit in the first set to win her No. 2 singles match, and No. 4-ranked Barry University women's tennis team shut out No. 9 California-Pennsylvania, 7-0, Wednesday.
Abanda, who battled illness earlier in the season, overcame 29 unforced errors in the first set in a big comeback win over No. 41 Lucie Rey, 7-6 (5), 6-1.
"I really had to start fresh, and not look at the score," Abanda said, compartmentalizing her approach from the 5-0 deficit. "I had to play to win, and not to lose. I was trying to be more patient, and it worked so I kept doing the same thing."
Abanda won six straight games after finding herself down 5-Love in the first set. Rey won the next game to send it to a first-set tiebreaker. But Abanda recollected herself in the tiebreaker to take the opening set.
"She seemed to be getting really nervous, so I thought to myself, 'If I stick to it, I can win this first set,'" said Abanda, who produced five winners in that set.
Abanda fired off one of her five aces in the match to take a 3-1 lead in the second set. Abanda capitalized on Rey's double fault to win the fifth game before wrapping up the match by winning the last two games.
"I feel like I have more confidence, and if that situation will reproduce, I can look back on that match and say, 'I did it. I can come back from 5-0 and win the set,'" said Abanda, who committed 11 unforced errors in the second set. "It's been technical. I wasn't really playing my game, and I really don't want it to be a habit. I want to get back to my game."
Emma Onila beat No. 31 Lucie Sipkova, 6-2, 6-2, at No. 1 singles. She is now 3-1 against ranked opponents. Karina Goia swept Maxime Colen, 6-0, 6-0, at No. 3 singles to improve to 14-0.
Akemi Maehama beat Elizabeth Guy, 6-1, 6-0, at No. 4 singles. Maehama wore down Guy with her patented looping volleys and eventual putaway winners.
Linda Fritschken and Kimmy Twelker won the only doubles match of the day, collecting two points for the Bucs for the second time in as many completed matches. The Bucs duo, who remain unbeaten together, defeated Alexandra Borgenhoff and Ramona Czakon, 6-3, 6-3, at the No. 1 pairs flight.
The Bucs (17-0) will host No. 1 and defending NCAA champion Armstrong Atlantic (14-0) 10 a.m. Friday at Buccaneer Tennis Center.


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Renal Transplantation and Raltegravir in HIV-Infected Patients (ANRS153TREVE)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01453192
Recruitment Status : Completed
First Posted : October 17, 2011
Last Update Posted : July 12, 2016
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV-1 Infection Chronic Renal Insufficiency
|Drug: Raltegravir
|Phase 3
Antiretroviral treatment of HIV-1 Infection might interact with immunosuppressive treatments which increase rejection of renal graft incidence.
In addition HIV infection may be modified together with cardiovascular risk. Patients participating to this study will receive after transplantation antiretroviral regimen including Raltegravir.
Raltegravir treatment does not interact with immunosuppressive drugs and thus seems to be the treatment of choice to be associated with immunosuppressive drugs.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|27 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|National, Multicenter, Phase III Prospective Trial About Clinical and Immunological Follow-up After Renal Transplantation in HIV-1 Infected Patients With End Stage Chronic Renal Insufficiency
|Study Start Date :
|December 2011
|Actual Primary Completion Date :
|November 2015
|Actual Study Completion Date :
|November 2015
Experimental: Raltegravir
Raltegravir associated to an antiretroviral regimen without ritonavir boosted antiprotease
Drug: Raltegravir
Introduction of Raltegravir 2 days after renal transplantation within an antiretroviral regimen without ritonavir boosted antiprotease
Other Name: Isentress
- Incidence of acute clinical renal graft rejection [ Time Frame: 6 months ]Incidence of acute clinical renal graft rejection defined by 20% increase of serum creatinine, associated to histological features (Banff classification) 6 months after renal transplantation
- Incidence of acute clinical and subclinical renal graft rejection [ Time Frame: 1 year ]Incidence of acute clinical and subclinical renal graft rejection up to 1 year after renal transplantation defined only by renal histology (without creatinine modification). Histology is performed on routine renal graft biopsy 3 months and 1 year after transplantation.
- One year graft survival [ Time Frame: 1 year ]One year graft survival, compared to non HIV-infected transplanted patients, using data provided by French Biomedicines Agency
- Patients' survival [ Time Frame: 1 year ]
Patients survival, compared to:
- chronic dialysis HIV patients still listed on the transplantation waiting list - transplanted non-HIV patients using data provide by French Biomedicine Agency
- Phenotyping of lymphocytic infiltrates in case of acute rejection [ Time Frame: 1 year ]The aim of the immunological phenotyping is to analyse the expression of activation markers between different TCD4 and TCD8 sub-population, this phenotyping will be compared to those observed in acute cell-mediated rejection occurring in the historical cohort of Non-HIV patients. In addition, the rate and expression of Treg population will be evaluated.
- Incidence of AIDS defined diseases and severe morbidity diseases after renal transplantation [ Time Frame: 1 year ]Severe morbidity diseases include: pathological infections, malignancies, metabolic and cardiovascular diseases.
- Immunological and virologic status after renal transplantation [ Time Frame: 1 year ]Immunological (lymphocyte activation and inflammatory parameters) and virologic status (kinetics of viral replication: HIV RNA in blood, total HIV DNA in PBMC) monitoring after renal transplantation. These parameters will be compared with pre-transplant status.
- Evaluation of the switch by raltegravir at the time of renal transplantation [ Time Frame: 1 year ]Assessment of ARV medications change and introduction of raltegravir at the time of renal transplantation in terms of reduction of pharmacokinetic interaction between antiretroviral regimen including raltegravir and immunosupressive treatments. In addition, virological efficacy of antiretroviral treatment including Raltegravir will be evaluated.
- Viral load control after switch by antiretroviral treatment including raltegravir after renal transplantation [ Time Frame: 1 year ]The aim of this study is to evaluate at the time of renal transplantation the virologic efficiency after the switch by an antiretroviral regimen including Raltegravir in terms of viral load control an virological failure as Raltegravir is known for its low genetic barrier.
- Survival and waiting period of HIV patients registered on French biomedicine agency for renal transplantation [ Time Frame: 1 year ]Assessment of HIV patients' waiting period until renal transplantation and survival of patients registered on French biomedicine agency waiting-list compared to Non-HIV population (data provided by French Biomedicine Agency )
- Measurement of Area under plasma concentration (AUC) variability of immunosuppressive drugs after introduction of antiretroviral regimen containing Raltegravir [ Time Frame: 1 year ]Area under plasma concentration (AUC) of Raltegravir and immunosuppressive drugs (Tacrolimus and Mycophenolate Mophetyl) will be measured as well as residual concentration of Tacrolimus. This study is performed in order to verify immunosupressive treatments dosage adaptation.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Registration on the French national renal transplantation waiting list (Biomedicines Agency) for a living or cadaveric donor organ
- HIV-1-infected patients treated by a three-drug ARV regimen
- Immuno-virologic criteria at renal transplantation: undetectable viral load (<50 copies/mL) and CD4 >200/mm3 for at least three months on stable ARV
- Age >18 years and <70 years
- Effective contraception for women
- Written informed consent
- Patient with social security coverage
Exclusion Criteria:
- Hepatic cirrhosis
- Serious psychiatric illness history
- EBV or HHV8 lymphoproliferation (lymphoma, systemic Kaposi's sarcoma or multifocal Castleman's disease)
- History of PML
- HTLV-1 seropositivity
- Severe pulmonary or cardiovascular disease with poor short-term vital prognosis
- Patient with AgHBs+
- History of cryptosporidiosis
- History of fungal infection with multi resistant fungi not likely to respond to oral antifungal therapy
- Impossibility or refusal of Raltegravir switch, decision made by doctor or patient
- Recent malignancy (between 2 and 5 years according to type)
- HPV-related cervical or anal disease: carcinoma in situ, AIN III, CIN III in remission for less than three years
- Active infection
- HCV infection (PCR-positive)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01453192
|Hôpital Pellegrin, Service de Nephrologie, Transplantation Rénale, Dialyse
|Bordeaux, France, 33076
|CHU De Caen, Service de Néphrologie Hémodialyse
|Caen, France, 14033
|Hôpital Henri Mondor, Service de Néphrologie Transplantation
|Créteil, France, 94010
|Hôpital Kremlin Bicêtre, Service de Néphrologie
|Kremlin Bicêtre, France, 94275
|CHRU Lille, Service de néphrologie
|Lille, France, 59037
|CHU de Nantes, Service de Néphrologie et Immunologie Clinique
|Nantes, France, 44093
|Hôpital Pasteur, Service de Néphrologie - Transplantation
|Nice, France, 06002
|Hopital Saint Louis, Service de Néphrologie
|Paris, France, 75010
|Hôpital Necker, Service de Néphrologie adulte
|Paris, France, 75743
|Hôpital TENON, Urgences Néphrologiques et Transplantation Rénale
|Paris, France, 75970
|Hôpital civil, Service de Néphrologie et Transplantation
|Strasbourg, France, 67091
|Hôpital Foch, Service de Néphrologie Transplantation
|Suresnes, France, 92151
|Hôpital Rangueil, Service de Néphrologie, HTA, Dialyse, Transplantation
|Toulouse, France, 31059
|Hôpital Bretonneau, Service de Néphrologie
|Tours, France, 37044
|Principal Investigator:
|Philippe GRIMBERT, MD
|CHU Henri-Mondor
|Study Director:
|Dominique COSTAGLIOLA, PHD
Additional Information:
|Responsible Party:
|French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
|ClinicalTrials.gov Identifier:
|NCT01453192 History of Changes
|Other Study ID Numbers:
ANRS 153 TREVE ( Registry Identifier: ANRS )
|First Posted:
|October 17, 2011 Key Record Dates
|Last Update Posted:
|July 12, 2016
|Last Verified:
|July 2016
Keywords provided by French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS):
Renal transplantation
Acute renal graft rejection
Additional relevant MeSH terms:
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Diseases
Urologic Diseases
Raltegravir Potassium
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
HIV Integrase Inhibitors
Integrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


text:
The first week of the volleyball season is in the books, and there might not be a bigger surprise around the Southland than Lockport.
The Porters made their first ever trip to the championship bracket at the 24-team Marist Invitational with pool-play victories over Andrew and Marian on Friday.
The wins didn't stop there.
Matt Sadler and Phil Holle put down six kills apiece as Lockport dispatched Lincoln-Way Central 25-22, 25-15 for a fifth-place showing on Saturday.
"That's the best finish we've ever had in this tournament," Lockport second-year coach Nick Mraz said. "In my opinion, we have a team that can compete with anyone. We'll fly under the...


text:
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Home / About TEA / News and Multimedia / Awards
Every fall, the Texas State Teacher of the Year Program honors 40 Regional Teachers of the Year, among which are two State Teachers of the Year — one in elementary education and one in secondary education — and four state finalists. These regional teachers represent each of the 20 Education Service Center regions in Texas.
An essay by Daniel Leija, the 2011 Texas Elementary Teacher of the Year, reminds us of the importance of all our Texas teachers.
The Texas Association of School Administrators (TASA) now administers the Teacher of Teacher of the Year Program. Information about the program, current winners, and the application process can be found on the TASA website.
For more information, contact: Jennifer GarridoTexas Teacher of the Year Program Coordinator (512) 477-6361Texas Association of School Administrators 406 East 11th Street Austin, TX 78701


text:
Lahm, Van Buyten, Dante, Alaba
Martinez, Schweinsteiger
Muller, Kroos, Robben
Piszczek, Subotic, Santana, Schmelzer
Gundogan, Bender
Blaszczykowski, Gotze, Reus
Bayern Munich will be without the serivces of star man Franck Ribery, who is suspended after being sent off in the last round against Augsburg, with Arjen Robben expected to step in for the Frenchman.
However, Javi Martinez has shaken off a minor groin strain which forced him off early against Werder Bremen at the weekend, while Daniel Van Buyten has shaken off the flu.
Borussia Dortmund, meanwhile, will be boosted by the return of Robert Lewandowski, who has missed their recent league games due to suspension.
Meanwhile, Mats Hummels is expected to miss out with flu and will be replaced by Felipe Santana, but Jakub Blaszczykowski has recovered from a minor injury.
- Bayern Munich have conceded just two goals since the start of 2013, both came in their last two matches.
- These two teams met in the final of the competition last season, with Dortmund recording a 5-2 victory over their rivals.
- Legendary coach Ottmar Hitzfeld (pictured, right) won this trophy three times with Bayern, but never during his six years with BVB.
- Borussia Dortmund have lost just once in their last seven meetings with Bayern Munich - in the Supercup in August.
- Mats Hummels started his career at the Allianz Arena, and moved to BVB in 2009, initially on loan.
- Ten of the 19 players called up to Germany's squad for the recent fixture against France play for one of these clubs.


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By: Sue Lewis, Category: Lifelong Learning, Date: 18 May 2010
Despite the cold weather the students found a number of golden orbs, leaf-curl spider, black house spiders (Badumna spp), Araneus species and others.
Museum in a Box Coordinator, Karen Player and I spent an interesting day at Ermington Public School investigating the spiders and insects. On the first really cold day of the year, the students still found abundant numbers of orb-weavers and weavers of lacy and tangly webs. The Web2spider toolkit enabled them to identify the spider species in their little patch of bushland without any collection or entrapment.
No spider was harmed in the making of this science lesson!
Golden orb spiders can still be seen until as late as August or even September, if they are in an area protected from frost. Once they have laid their eggs, (usually in a golden sac off to one side of its web among the bushes) they are more inclined to die off as their life cycle is complete.
Leaf–curl spiders (Phonognatha graeffei) will create a little "purse" from a leaf for its eggs.
This would be a good time for the students at Ermington to be on the look-out for spider egg sacs too!
Tags web2spider, Ermington Public School, spiders, webs, leaf-curl spiders, golden orb spiders, orb weavers,
Year 5 may like to revisit the site where we surveyed spiders and look out for the golden sacs of eggs that belong to the Golden Orb spider. The numbers of Golden Orbs will diminish as the weather gets colder and they have finished their life cycle, that is they have reproduced another generation of spiders! Looking forward to the next Web2spider survey year carries out.
We are impressed by your sharp observational skills.
Hello Carolyn,
I'm not sure why you would have found more spiders in the open area than under trees (as I wasn't at the site) but I can make a few guesses - (a)it was sunnier out there and at this time of year invertebrates would need to bask to gain heat before they could become active, (b)the open area might have been in a natural 'funnel' or depression that would concentrate travelling invertebrates, OR it could have been the edge zone between one type of habitat and another - these EDGE areas have far greater diversity than most other 'pure' habitats/environments as they get fauna from the two adjacent habitats AND fauna which is unique to EDGE areas as well (c) the open area might be slightly raised and animals escaping from waterlogged ground will be heading there.
As for spiders in trees that's where many species spend their whole lives. The species of spider concerned will determine where you would expect to find it.
I hope this helps?
Martyn Robinson