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China 2019 – Day 4, Sunday, 21st July
Heat and humidity meant a lack of sleep last night and a slightly later start to the day today but as planned yesterday, I had a longer walk along the river to see if I could follow it all the way to Yangshuo, the closest town.
The closer I got, the more tourists I saw on bamboo rafts and cycling along the path – I like to get away from things so this wasn't a good sign – although the scenery continued to astound… it really is beautiful along the river.
After walking for a couple of hours I reached quite a built up area about 5km outside of Yangshuo, sat for a little rest to prepare for a final push into town, when a young guy on a moped stopped and asked if I wanted to go somewhere.
Demonstrating the tai chi principles of energy preservation and conservation of movement – along with the common sense principle of not wanting my blisters to get any more painful, I gratefully took him up on his offer and for a nominal fee, I was whisked into town on the back of an electric scooter.
I'll head back and explore Yangshuo a little more at some point but it was quite a bustling little town, lots of nice looking Chinese eateries serving the local specialities of beer fish (got to try that one) and Guilin noodles.
So a quick walk around and then a taxi back to my small and quiet Jima safe haven, a quick lunch and then a couple of hours tai chi practice in the wet and humid afternoon heat (including a torrential downpour and some loud thunder).
One of the great things about being here training is the opportunity to try something different and new, I feel like a beginner again – both in Tai Chi and in Mandarin. I think it's so important in a person's continual development to keep on seeking challenges, learn new things.
Complacency and comfort zones are two of our greatest enemies!
Putting yourself in a position where you are a beginner is also a great way to keep your ego in check – and in the martial arts world egos can run wild!!! Especially among instructors.
Running your own classes and clubs it's easy to imagine yourself upon a pedestal, as you are obviously going to be the top of the tree in your organisation – and occasionally students can place you upon one (luckily none of mine do but if they did, I'd ride down from the heavens on my giant white crane and tell them that I was actually a mere mortal, obviously).
I love coming here and getting my ass kicked at pushing hands, scratching my head as to how a new move works in a form, or a how a subtle shift of the hips can be the difference between standing and falling, grasping to find the meaning in what someone is talking to me about in Mandarin – and gradually, inch by inch you find yourself slowing improving…
What's more, as an instructor, it's good to remind yourself how a new student feels when starting to learn a tai chi form – and for my students back home, it's good for them to know that I'm being given the same treatment that I subject them to week in week out in classes 🙂
Evening was spent having some very tasty red tea after dinner, some more forms training – accompanied with occasional leg slap or mid air clap as I worked on my self defence from mosquitoes!


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Our text today follows on in the same general theme from last week where Peter called us to 'set [our] hope on the grace to be brought to [us] when Jesus Christ is revealed at His coming' (1:13). In this early part of chapter 2, Peter is most concerned that we understand our identity as temporary citizens living expectantly in this world. He employs 3 word pictures to describe our identity as followers of Jesus - a) like little children, put off evil habits and crave the goodness of God (1-3); b) like living stones, you are being built together to offer up spiritual sacrifices; c) YOU ARE a chosen people; a royal priesthood; a holy nation; a people belonging to God SO THAT you may declare (proclaim) His praises (excellencies) - he has called you out of darkness into his marvelous light! May we understand and live out our identity in increasing measure!
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November 2023

subset: commoncrawl


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I lived in Daegu, South Korea from 2013-2014. While there, I tried many foods. I fell in love with a few and stayed away from many. (Due to the fact that I was anemic, and also didn't want to end up in the hospital in a foreign country.)
One of the foods I fell in love with in Korea were the mochi donuts, available only at Dunkin Donuts. Whenever friends and I stopped by DD for some donuts, I had to grab at least 2 of these non-western donuts.
Mochi donuts, or chapssal donuts (찹쌀도너츠), are a modern take on the traditional Korean rice cakes. They are made from sweet rice flour and filled with a sweet red bean paste. Although I like my mochi donuts without any filling–and especially from Dunkin Donuts–chapssal donuts can be found at any market stall in South Korea.
Today, I am back in the U.S., where the Korean mochi donuts are nowhere in sight. Therefore, I have decided to make my own, tweaking Seonkyoung Longest's recipe for mochi donuts.
For Dough:
- 1 c. sweet rice flour
- 2 Tbs. all purpose flour
- 1 Tbs. cocoa powder
- ¼ c. sugar
- ½ tsp. Salt
- 1 tsp. Baking powder
- 1 Tbs. melted butter
- ½ c. + 2 Tbs hot water
For Glaze:
- 2 Tbs. butter
- 1 c. powdered sugar
- ½ tsp. vanilla extract
- 2 Tbs. cocoa (optional)
Other Material:
- Frying oil
- Wax paper
- Sprinkles (optional)
To make the dough, combine all the dry ingredients in a bowl. Then add the melted butter and hot water. Use a spatula at this point to form the dough. Once everything has combined and cooled, go in with your hands to knead the dough for 5 minutes.
Next, allow the dough to rest for 15-30 minutes. Cover with plastic wrap and a kitchen towel.
Afterwards, roll the dough into a long log and pinch off some dough (roughly 1.5 cm in diameter) and shape them into balls. On wax paper, form about 9 dough balls into a ring. Then heat up some frying oil and place the donut ring and the wax paper, into the oil. Fry for 2-3 in total–making sure to turn the donuts over and remove the wax paper from the oil.
Pour on your glaze of choice, and sprinkles, and enjoy!


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Welcome to SMP Health. Our story begins in 1902 when the first Sisters of Mary of the Presentation arrived in North America as religious exiles from their native France. They established their first hospitals in Spring Valley, Illinois in 1903 and Bottineau, North Dakota in 1913. What they started at that time now includes quality care delivered by our three critical access hospitals and six nursing homes in North Dakota and our hospital and home health agency in Illinois.
We are proud of our history rooted in the Sisters of Mary of the Presentation, our sponsor. Their charism and spirit animates our work to fulfill the healing mission of Jesus Christ in the Catholic tradition. We are proud of the work we do and those who do it. Whether you are seeking care or seeking employment, I think you will find our faith-based health care ministries prepared to meet your needs and expectations. I hope you will take some time to learn about them by exploring our website.
Aaron K. Alton
President & CEO


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Your brakes are the most important system in your car for keeping you safe. Being able to stop the car quickly and safely will help keep you from getting into any collisions. Unfortunately, the environment we live in can be detrimental to your brake lines and can cause them to fail and leak.
Typically, the metal brake lines on your car are made from steel to keep costs down, but steel is susceptible to corrosion, especially during winter when there is often salt on the ground. If you have to replace a brake line, you should consider upgrading the line to a copper-nickel line that is much more resistant to rust and corrosion.
Part 1 of 3: Removing old line
Materials Needed
- Flathead screwdriver
- Gloves
- Jack
- Jack stands
- Line wrench
- Pliers
Note: If you are only replacing one line, it may be cheaper and easier to buy a pre-shaped line instead of buying all the tools to make your own. Do some pricing and see which option makes more sense.
Step 1: Go over the brake line that you are replacing. Inspect every part of the line that you are replacing so you can see how and where it is secured.
Remove any panels that are in the way. Be sure to loosen lug nuts before you jack the car up if you have to remove a wheel.
Step 2: Jack up the car. On a flat, level surface, jack the car up and lower it onto some jack stands to work underneath.
Block off any wheels that are still on the ground so the car can't roll.
Step 3: Unscrew the brake line at both ends. If the fittings are covered in rust, you should spray some penetrating oil on them so it is easier to take them off.
Always use a line wrench on these fittings so you don't round them off. Have your rags ready to clean up any spilled fluid.
Step 4: Plug up the end that goes to the master cylinder. You don't want the master cylinder to leak all of the fluid out while we make our new brake line.
If it runs out of fluid, you'll have to bleed the whole system as opposed to just one or two wheels. Make your own plug with a short section of tubing and an extra fitting.
Pinch one end of the tube flat with the pliers and fold it over itself to make a seal. Put the fitting on and flare the other end. Now you can screw this onto any piece in your brake line to stop fluid leaking out. More information on flaring the tubing in the next part.
Step 5: Pull the brake line out of any mounting brackets. You can use a flathead screwdriver to pry the lines out of any snap in clips.
Take care not to damage any other lines that are mounted near the brake line.
Brake fluid will be coming out of the ends of the line. Make sure to clean up any drips on the paint as brake fluid is corrosive.
Part 2 of 3: Making a new brake line
Materials Needed
- Brake line
- Brake line fittings
- Flaring tool kit
- Flat metal file
- Gloves
- Safety glasses
- Tubing bender
- Tubing cutter
- Vice
Step 1: Measure the length of the brake line. There will likely be a few bends so use some string to get the length and then measure the string.
Step 2: Cut the tubing to the correct length. Give yourself an extra inch or so as it is hard to bend the lines as tightly as the factory.
Step 3: Mount the tube into the flare tool. We want to file the end of the tube to make it smooth, so have it slightly raised in the mount.
Step 4: File the end of the tubing flat. Prepping the tubing before flaring it will ensure a good, long lasting seal.
Remove any burrs left on the inside with a razor blade.
Step 5: File the outside edge of the tubing for fitting. Now the end should be smooth and free of any burrs, placing a fitting on.
Step 6: Flare the end of the brake line. Mount the tube back into the flare tool and follow the instructions for your set to create the flare.
For brake lines, you'll need a double flare or a bubble flare depending on the model of vehicle. Do not use a single flare for brake lines as they can't handle the higher pressure of the brake system.
- Tip: Use some brake fluid as lubricant when forming the end of the tube into a flare. That way you don't have to worry about any contaminants getting into your brake system.
Step 7: Repeat steps 3 to 6 on the other side of tubing. Don't forget the fitting or you'll have to start over.
Step 8: Use the tube bender to form the line into the correct shape. It doesn't have to be exactly the same as the original, but get it as close as possible.
This is so you can still secure the line with any clips. The tubing is malleable so you will be able to make small adjustments when it's on the car. Now our brake line is ready to install.
Part 3 of 3: Installing your new line
Step 1: Get the new brake line in place. Check to make sure that it reaches both ends and will still go back into any clips or mounts.
Leaving the line out of any mounts may cause flexing while driving the vehicle. Flexing in the line will eventually make another leak and you'll have to replace it again. You can use your hands to bend the line to make small adjustments.
Step 2: Screw in both sides. Start them by hand so you don't cross thread anything and then use your line wrench to tighten it.
Snug them down with one hand so you don't over tighten them.
Step 3: Re-secure the brake line with the mounts. As mentioned before, these mounts keep the line from bending and flexing so use all of them.
Step 4: Bleed the brakes. You should only need to bleed the line or lines that you replaced, but if the brakes are still spongy, bleed at all 4 wheels to be safe.
Never let the master cylinder run dry or you'll have to start over. Check the connections that you've made for leaks while the brakes are being pumped.
- Note: Having someone pump the brakes while you open and close the bleeder valve makes this job much easier.
Step 5: Reassemble everything and put the car back on the ground. Make sure everything is properly in place and the car is securely on the ground.
Step 6: Test drive the vehicle. Before you start moving, do one last leak check with the engine running.
Pump hard on the brakes a few times and check for any puddles underneath the car. If everything looks good, test the brakes at a low speed in an empty area before going into traffic.
With your brake line replaced, you won't have to worry about any leaks for a while. Doing this at home can save you money but if you need any assistance, Ask a Mechanic for some helpful advice on the process, and if you notice your brakes are hard to push, one of YourMechanic's certified technicians perform an inspection.
Next Step
Schedule Brake Pedal is hard to push Inspection
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For my Project 52 post, I thought I'd comment about a recent Pew report has come to my attention via DownloadSquad that says that young people are blogging less:
Pew Internet released a report yesterday called Social Media and Young Adults that shows teen blogging down by 50% over the past four years, even as blogging increased among those over 30 years old.
The report also shows that teens are not very likely to be Twitter users (only 8% of internet users between the ages of 12 and 17 report using the service), even though they are heavy users of almost all other online applications; in fact, 73% of "wired American teens" are social networking website users. Twitter seems to stick out as a service that younger people are not as interested in.
The report is really talking about teens – 12 to 17 year olds – and I have to say that the conclusions follow my observations. While I grew up before the Internet and social networks became ubiquitous, I remember MSN and ICQ were used widely. With Facebook and MySpace (and their in-house chats), it seems to me that most young people are more interested in talking with each other.
DownloadSquad also concludes that young people aren't "content creators".
I'm not sure I agree with that. Rather, I think young people only share their content – photos and videos – with their friends, rather than putting them on Flickr or a blog.


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Wednesday, November 6th, 2013
Los Angeles Clippers at Orlando Magic +7 Total: 208
The Clippers are off to a flying start this season as their offense continues to put up monster numbers, but the situation is two-fold with the Clips as their defense has been suspect.
After dropping their opening game to the cross-town L.A. Lakers, they have won three straight games. They are averaging just over 124 points on 50.6 in these games as they head for a fourth straight win against the Magic.
Chris Paul has dominated this season, averaging 26.5 points and a whopping 13.3 assists in the four games and has recorded four straight double-doubles. Newcomer J.J. Redick, who is facing his former team this evening, has been spectacular, as well. He is averaging just over 14 points per game on 50 percent shooting so far this season.
Offensively, the Clippers are the best team in the league at this point, but their defense needs some work. They currently are giving up over 112 points per game and allowing teams to shoot over 48 percent from the field.
The Magic, who come into the game with a 2-2 record, may also be hitting their stride. Projected to be one of the worst teams in the NBA, Orlando has surprised opponents so far.
After handling the New Orleans Hornets on Friday, the Magic beat the new look Brooklyn Nets in a 107-86 rout. Previous 76er castoff Nikola Vucevic scored 19 points, and first round pick Victor Oladipo scored 19. Their current leading scorer is veteran guard Arron Afflalo who is averaging just over 20 points per game.
Their defense has also been impressive. They held the Nets and the Pelicans to just fewer than 37 percent shooting in their two victories.
The Clippers are clearly playing terrific basketball, but the Magic are not the pushovers that everyone thought they would be. Although it seems early to talk about the schedule, I think this may be a decent "look ahead" trap game for L.A. Not only are the Clippers flying across the country, but they face Miami in a primetime matchup on Thursday.
They have shown that they can be scored upon easily, and their frontcourt is not imposing defensively other than DeAndre Jordan. Their backcourt is a mess defensively. I'm looking for the Magic to catch them off guard in this one and put up solid numbers. This team can score, and there is no team right now that is worse defensively than Los Angeles.
Pick: Magic +7 with Topbet.eu
Golden State Warriors at Minnesota Timberwolves pk Total: 208.5
The Warriors began their road trip with a dominant win over a surprising Philadelphia team. As they head to Minneapolis Wednesday, they will try to take care of another team that has been a surprise in the West.
Stacked with talent, Golden State's offseason signing of Andre Iguodala is already paying dividends. "Iggy" hit a career high seven three-pointers in a 110-90 win against his former team, the 76ers. Stephen Curry notched a triple-double in the win and Klay Thompson also added 15 points.
Warriors forward Harrison Barnes could make his season debut in this contest as he nurses back an injured foot. Barnes is a key contributor and will give this already potent team a bigger boost.
At 3-1, the Wolves have shocked some teams this year, and while some may doubt their talent, I think this team is a playoff contender. The offseason signing of Kevin Martin has been massive for the franchise. The veteran guard is shooting over 60 percent from three-point land and has scored over 20 points in three out of their first four games.
Minnesota's first loss of the year looked to be a blowout, but the Wolves rallied late, from a 23-point deficit to lose by just one point. Martin and All-Star Kevin Love have been the key contributors for the Timberwolves so far, but the team will need some help carrying the load offensively. Guard Ricky Rubio, who electrified the league at certain times last season, continues to struggle with his shot. He has gone 3 for 18 in the last two games, scoring just 12 points.
Minnesota's play has been extremely impressive; especially when you consider they had a blowout wins against the Oklahoma City Thunder and New York Knicks, but I think the Warriors are on another level talent wise.
Rubio is no match for Curry's offensive prowess and Igoudala should render Martin useless on the perimeter. Love is impossible to stop, and David Lee is terrible defensively, but he will have a much tougher time grabbing boards with Andrew Bogut controlling the paint.
Golden State still has a lot to prove in this league and won't be overlooking anyone just yet. I like them to get a win in this one.
Pick: Warriors pk at Topbet.eu
Utah Jazz at Boston Celtics -3.5 Total: 185
Both of these teams are winless heading into tonight's contest as the Utah Jazz head to TD Garden to take on the Boston Celtics.
After a flurry of offseason moves that sent Paul Pierce and Kevin Garnett to the Brooklyn Nets, the Celtics have a bunch of fresh faces as they build towards the future. However, there have been some early growing pains. Shooting just 26 percent from three and averaging a league-worst 21 turnovers per game, the Celtics have been killing themselves in recent action.
After leading by six points with nine minutes left at Memphis, the Celtics blew the lead late and allowed the Grizzlies to come from behind and win 95-88. The Celtics hope to get a win behind their home crowd tonight as they seek to avoid their worst start since the 1946-1947 season.
The Jazz, also one of the league's most turnover prone teams with just under 20 have struggled just as mightily. They will also attempt to stave off one of the franchise's worst starts since dropping 11 straight games to start the season over 39 years ago.
After keeping things close with most opponents, Utah was essentially out of the game in the second half and trailed by as many as 26 points. Enes Kanter, of all people has been the team's leading scorer, averaging 17.8 points and 9.5 rebounds so far.
While it is hard to predict much from these two winless teams, someone is going to get a win tonight, and I think it will be the Celtics. The home crowd will be behind them if they can put up even an average effort. The Cs are best at home while Utah has historically struggled on the road. The Celtics have won five straight games in this series, and I expect them to add to that total tonight.
Pick: Celtics -3.5 with Topbet.eu


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Wednesday, April 20, 2011
5 comments:
omgness! I think the same thing everytime I watch that show! I love the idea of donating -but otherwise it should be called "Extreme Couponers Who Hoard" :DReplyDelete
That show just cracks me up...Im impressed by their savings but seriously..what do you do with all that crap??!!ReplyDelete
I've always wondered the same thing. I like to save a little money here and there, but I don't have the room to store 50 bottles of mouth wash! I've never seen the show. I am going to have to look it up!ReplyDelete
I'm all for using coupons to help out charitable organizations and saving money, but I do believe you are correct about some of these couponers treading on a slippery slope at times. I know I've stockpiled before, but I'm realizing that not only do I not have room to do that, most of it just goes to waste.ReplyDelete
It's an addiction...ReplyDelete
Not so much the couponing or the hoarding, but me watching the couponing and the hoarding.
I. Can't. Look. Away.
And the amount of time it takes to go from one to the other is "the length of the drive from the store to home".


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Latest on smoking and Covid-19: E-cigarettes, hookahs or tobacco - it may increase your risk
The first comparative study of the effects of three forms of smoking shows that it may increase the risk of being infected with Covid-19.
Smoking in all its forms may increase your risk of contracting Covid-19.
This comparative research is the first in the world to investigate three methods of smoking.
Respiratory and cardiovascular diseases associated with smoking are comorbidities which can lead to severe Covid-19.
As the ban on the sale of tobacco products in South Africa continues, there is some debate on whether cigarette smoking directly affects your risk of getting Covid-19.
There have been investigations into the risk of smoking e-cigarettes vs traditional cigarettes, but there are few comparisons between the effects of e-cigarettes, hookahs (waterpipes) and traditional cigarettes.
Recently, however, a comparative study from the European Society of Cardiology investigated the effects of different methods of smoking, including e-cigarettes, tobacco cigarettes and hookahs, and found that they all play a role in causing inflammation and damage to DNA.
The research was published on 25 June in the European Heart Journal.
Even nicotine-free e-cigarettes can harm blood flow, study finds
New research has found that vaping temporarily is enough to impact the body's blood vessels.Scientists from the University of Pennsylvania asked 31 nonsmoking participants to inhale electronic cigarettes 16 times for three seconds each.
First comparison of three forms of smoking
This study is significant, as it's the world's first comparison of the effects of three forms of smoking on human health, and especially the function of cells in blood vessels, according to a news release.
The researchers stated that there was plenty of evidence to suggest that tobacco cigarettes were more harmful than e-cigarettes, but there was a lack of large studies on the true effects of waterpipes and e-cigarettes. They stressed that the long-term effects of these forms of smoking should be investigated to gain clarity about whether they are more harmful than traditional cigarettes.
According to the study, tobacco cigarettes increased the risk of COPD by 704%, waterpipes by 218% and e-cigarettes by 194%. The risk of lung cancer increased by 1 210% in the case of cigarettes, and 122% with e-cigarettes.
They also investigated the effect of these three smoking alternatives on the stiffening of arteries.
Additionally, the researchers looked at the main toxic chemicals present in e-cigarettes. According to the authors, nicotine is present in all three alternatives. Nicotine may have harmful and addictive effects on the body.
Smoking and Covid-19 – what is your risk?
According to the new research, both smoking and vaping (smoking e-cigarettes) may increase your risk of being infected by Covid-19 and suffering more severe symptoms than non-smokers. They suggest that health authorities urge those who smoke to try and quit, no matter whether they smoke traditional cigarettes, smoke waterpipes or vape.
They stated the following in the paper: "As outlined by the WHO, tobacco cigarette and waterpipe smoking may contribute to an increased burden of symptoms due to Covid-19 compared to non-smoking, including being admitted to intensive care, requiring mechanical ventilation, and suffering severe health consequences."
They also state that smoke cessation is the most powerful approach to prevent any smoking-induced health conditions such as cardiovascular and respiratory disease, and in the light of Covid-19, these are comorbidities that can significantly increase your risk of a more severe form of the illness.
"Given the well-established harms associated with tobacco use and secondhand smoke exposure, the WHO recommends that tobacco users should quit. Proven interventions to help users give up include toll-free quitlines, mobile text-messaging cessation programmes, nicotine replacement therapies and other approved medications, particularly if you have smoked for a long time, and especially if you use tobacco cigarettes and waterpipes.
"The WHO also warns that although e-cigarettes appear to be less harmful than tobacco cigarettes, there is growing evidence that they also may cause side effects in the lungs, heart and blood vessels and that e-cigarette use may increase the risk of Covid-19 infection," said leading study author Professor Thomas Münzel, of the Department of Cardiology of the University Medical Centre Mainz in a news release.
Originally appeared in Health 24
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Already two years ago, STOP, a tobacco industry watchdog, released reports on British American Tobacco (BAT), providing in-depth analyses of BAT's business practices in South Africa and across the con


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About this lesson
Learn how to create an effective column chart by reducing ink and 'noise' that distract from the main messages.
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Exercise files
Download the 'before' and 'after' Excel workbooks from the video tutorial and try the lesson yourself.Building Column Charts
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Quick reference
Building Column Charts
How to create an effective column chart by reducing ink and noise that distract from the story.
When to use
Use to remove distracting elements from your data whenever you are charting. Doing this will help you convey your message to your readers as quickly as possible.
Charting Goals
- Every chart should tell a story, quickly and effectively
- Extra chart elements create noise, and get in the way of the story
- It is a best practice to remove as much excess ink (noise) as you can
Creating a Column chart
- Select cells A5:B9
- Go to Insert --> Charts --> Recommended Charts and select the Clustered Column chart
Adding context
- Right click the data series (columns) and choose Add Data Labels
- Select the data labels, right click and choose Format Data Labels
- Set the Label Position to Inside Base
- Change the font (Home tab) to bold and white
- Select the chart title, press the equals key, click on A3 and press Enter
- Right click the columns, choose Format Data Series and set the Gap Width to 60%
Reducing Ink
- Select the horizontal gridlines and press Delete
- Select the vertical axis and press Delete
Lesson notes are only available for subscribers.


text: Well I just got done watching the season finale of the new FX show "The Americans," and I got to say that so far my mind is blown. I'm really starting to think this might be my new favorite show on TV. Is anyone else out there a fan? If so, any thoughts?


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To inform and empower the entire cancer research community by making breakthrough
discoveries in basic and clinical cancer research and by developing them into novel
therapeutic interventions for adults and children afflicted with cancer or infected
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Twelve of Europe's biggest clubs have joined forces to create a new controversial competition: European Super League, but what will the League's format be?
20 teams will play in two leagues before a two-leg knockout format to determine the two finalists.
European Super League Teams
Six English clubs, three Italian sides and three Spanish teams are set to be in the tournament which has long been in the offing, despite significant opposition from UEFA and the respective leagues.
Reigning European champions Bayern Munich and last season's Champions League finalists Paris Saint-Germain are not included, though it is said the competition plans to expand to 15 teams before its inaugural season, which will start "as soon as practicable".
Premier League sides Manchester United, Manchester City, Arsenal, Chelsea, Liverpool and Tottenham have signed up alongside Real Madrid, Barcelona, Atletico Madrid, Juventus, Milan and Inter.
European Super League Proposal
UEFA, along with Europe's top five leagues and corresponding football associations, all strongly emphasized their opposition to the proposal, and vowed to sanction those involved.
In a statement issued on Sunday, the new competition's organisers revealed its format.
Fifteen founding clubs will be joined by five further teams, who it is said will qualify annually based on achievements in the prior season.
European Super League format
Starting in August – although the statement did not confirm whether that will be this year – clubs will be split into two groups of 10, playing home and away fixtures, with the top three in each group automatically qualifying for the quarter-finals.
Teams finishing fourth and fifth will then compete in a two-legged play-off for the remaining quarter-final positions.
European Super League Fixtures
A two-leg knockout format will be used to reach the final at the end of May, which will be staged as a single fixture at a neutral venue.
SEE ALSO | All Ghana Black Stars Coaches: An Historic List Till Date
The statement said all fixtures will take place in midweek, with clubs continuing to compete in their respective national leagues.
This article was most recently revised and updated 3 years ago


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Have your circumstances changed? Do you have a specific item you need cover for?
A kit and contents insurance policy is essential to cover for loss, damage fire and theft to your issued or temporary uniform and equipment, your own kit such as laptops and mobile phones, as well protection for your belongings in either your living quarters on camp or at home, and that's worldwide.
Most service people will have attended a finance brief at some point, but you may not have picked up the many added benefits to a military kit and home policy.
Here's ten things on our Trinity Kit & Home insurance policy:
- Cover for theft or loss of cash or credit cards – this could be either from on your person or from your room or home
- Option to cover a bike on the policy (£400 cover included with the option to cover a more expensive bike)
- When you are moving around, such as deployment or posting overseas your belongings are covered in transit and storage if required (By professional movers or MOD)
- There's £75K legal fees cover included, so if you need to fight a legal battle you have some financial support
- Family cover options – if you have children at boarding school or university, their items are covered up to £3K
- License to occupy as standard – imagine if there was a fire in your room from a phone charger (it does happen), you would be liable for up to £20k for the damage to your room.
- Do you play a contact sport? You'd be covered up to £3m if you were to injure someone whilst playing sport
- Cost of other accommodation if you are unable to live in your quarter following a major mishap (up to 35% of sum insured)
- Gifts, worth up to £3000, bought for special occasions such as weddings or Christmas are covered for loss or damage
- If your freezer breaks down the contents up to the value of £1000 are covered
With Trinity's policy there is no credit agreement that may affect your credit rating, just a direct debit taken on the 1st of each month.
You can also manage your own policy through our unique self-service customer portal once you have registered.
To get a quote for your military kit insurance click here.


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Japanese Food Guide
|Pronunciation Buttons
Atsukan ('熱燗', is classified into Alcoholic beverage), is known as Hot Sake in English, and 热日本清酒 (Rè rìběn qīngjiǔ) in Chinese.
Rare :
Japanese (日本語)
Alcoholic foods or drinks.
1.Other namesWarmed Sake, Hot Rice Wine, Hot Japanese Sake.
Chinese: 烫清酒.
The general overview
2.The basic ingredientsSake.
3.The different ingredients according to the restaurants-
4.Type of cookingHeating.
5.TasteTasty (Sour, Sweet).
6.Serving temperatureHot.
7.Prevailing PriceAbove ¥880 (180ml; in Tokyo)
8.Japan Restaurant Search・GURUNAVI
English 简体中文 繁體中文 한국어 ภาษาไทย
・Hot Pepper Gourmet
English 简体中文 繁體中文 한국어
English 简体中文 繁體中文 한국어
ReferencesWikipedia 'Sake'
|See more than 1000 different Japanese food
Food Search


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Comprehensive school kids - no really
A new Awful Czar has been appointed today, leading already to any number of witticisms playing on the two words, the first implying the performance of the second.
Recent figures recently released today about recent things shows that Awfulness is up mumblety-mumblety percent. Faced with the rise of Awfulness amongst the young, two measures are being put forward. The first to tax it, the second to make Awful people enter council-sponsored Awful Domes whereby two men enter, one man leaves. Or women. Or a sort of gestalt awful gender. Like skinny Goths. And the sort of young heavy metal lads you don't see any more that despite the denim and the Iron Maiden look less like Hell's Angels than, well, Goths look like they think they look. I quote.
Concerns have been raised widely in various frightening papers about the spread of Awfulness away from clearly disturbed young people eating madness-cake and smoking banana skins to pretty much everyone under the age of middle. Sprayed with orange squash, everyone of the age less than middle has been infected with Awfulness, a disease that costs an unspecified country, maybe this one, who knows, a kazillion pounds a year in ill-advised high-heel topplings alone.
'Back in my day,' Awful Czar Clive Lighthouse-Family has announced, 'We were never young, and we didn't waste our time at Oxbridge on tatty-trade degrees such as Media Studies – where jobs can be had much to my dismay, but Classics. The country's shortage of Classical degrees is why we're not Hellenistic Greece. The birthplace of Democracy, whereby these beardless-youths wouldn't have the vote they never cast. In schools such as Fenn Street and St Trinians even teenagers had the good grace to be well into their twenties,' and, 'In my day.'
The new classification of age-before-middle is said to include having been too young to have ridden a chopper pushbike, enjoyed a packet of spangles, or still wonder to this day what happened to John Craven on Newsround*?
*It's a whole body-snatchers thing, in case this includes you.


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During interrogation, both Bill and Eric were quite prepared to protect each other and claim fault to save the other. This made absolutely no sense to me. In my review of Turn!, Turn!, Turn!, I commented on their dedication because this makes no sense, given their history of antagonism and occasional moments of grudging respect; but it seems that they are continuing Bill and Eric's excellent adventure. In the end, to save their lives, Bill reveals that not only is Russel Edginton not dead, he is on the loose. Roman is upset by Eric's excuse of wanting Russel to suffer and threatens to stake Bill, but Bill promises to end Russel as a final act of solidarity.
This episode, we finally got to see how Eric and Pam met. I am not normally a purist, especially given that the original text was written by Charlaine Harris, however; having Pam as a madam in the early 1900's just did not work for me. It actually makes Pam a lot younger and therefore less powerful than she is in the books and it means that she didn't evolve into who she is, but was always jaded and hard. In the books, Pam left with Eric to avoid the restrictions placed on her as a woman.
Well, it seems that the predatory gay man is going to be the theme for this season's True Blood. Each year the writers seem to pick some trope to beat us to death with. This year the trope is embodied by the closeted and predatory Steve Newlin. After admitting that being a vampire gave him the strength to go after what he really wanted, Newlin went on television to sell the idea of vampires wanting peace and unity. When asked if he had someone special in his life, Newlin made a point of using a female pronoun.
If that were not enough, Newlin decided to crash Jessica's party to buy Jason from her. When he offered her ten thousand, she started to talk to him about how hard Jason's ass is, along with his other assets. Newlin became so aroused at the thought of a naked Jason that he began to breathe hard, his fangs dropped and he got an erection. In turn, he was belittled and laughed at by Jessica. When a fight broke out between the two, instead of punching, he actually pulled Jessica's hair. Is there any trope that they won't have him live out? What he was suggesting was horrendous and predatory but the whole situation made his attraction to Jason appear deviant and dirty.
Unfortunately, we have to talk about Sookie. Was I the only one who cheered when Tara instantly made her snack food? Pam had to order her not to bite Lafayette and Sookie. When Sookie started looking for support in dealing with Tara, Pam made it clear that she was on her own and that she still expected a debt, before taking off. Clearly Lafayette and Sookie were terrified of Tara. Sookie even had to use silver to get her into the basement hideaway.
Of the two, only Lafayette felt any guilt for the decision that he made. He was honest about Tara being all he had, whereas Sookie could only do her glass is half full routine. I am glad that Tara didn't actually forgive Sookie. Too often their relationship has been so unbalanced, with Sookie's wants and desires being put first. Lafayette is right, the decision to turn her was selfish.
In other irrelevant plot lines, Terry Bellefleur is going through something dark. He was aggressive to the point of throwing Arelene across the room and even yelled at her. He kept having flash backs to his time at war. I think in a show about hyper able beings that it is important to have someone disabled, but I fail to see how this plot line can possibly come together with everything else that is happening on the show. It's enough to make me wonder if Alan Ball has ever heard of the miracle of the plot box. Minor characters don't need their own plot.
Jason keeps having his wild ways come back to haunt him. It almost suggests that Newlin is his punishment for daring to be too sexually active. One boy comes into the station and punches him for sleeping with his mother. Jason takes this to heart and seeks out Hoyt to apologize and offer up his house, so that Hoyt doesn't have to live with his mother. Once again Hoyt says no and tells Jason to leave. For her part, Mrs Fortenberry promises to bake for Jason in thanks. The relationship between Hoyt and Jason is yet another bit of storyline that we don't need to keep touching base with.
Jason doesn't really have to be too sad about losing Hoyt because he still has Andy. Together they come across Debbie Pelt's minivan. This is the last vehicle I would have expected this messed up werewolf to drive. Debbie had some V in a side panel and Andy struggled, but eventually handed it over to Jason.
Sam's noble routine is rewarded by being allowed to leave with his life after Alcide refuses to eat the body of the former pack leader. For all the drama, we all know that Alcide is going to become pack leader and so I wish they would get it over and done with already. When Luna and Sam head back to her place, they end up in argument when her mother in law knocks on the door demanding to see her grandchild. Luna gets her back up and says that her daughter is a shifter and not a werewolf. When Sam points out that she could be wrong, Luna does the either you're with me, or against me routine and gives Sam the heave ho. Again, why should I care whether these two are getting along or not?
In the moments when the story is centered on the main characters, nothing beats True Blood. The ridiculous attention on these side plots however, is nothing more than a meaningless distraction and empty filler. Given that True Blood has such a short season, leaving the viewer always wanting more, the refusal to stay on task is so incredibly frustrating. As much as like Terry, I want to see less of him, not more.
What were your thoughts on this episode and its treatment of side characters?


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A design for storytelling by Andreas Nicholas, GlobeMed
My first job as a designer/filmmaker in the development field is to consider my approach. During my time in Gulu, I saw firsthand the Western tendency to arrive with pre-conceived notions of the place and to develop quick or easy 'solutions' to problems based on Western knowledge. To be honest, there is really no set of knowledge that can be applied to development work as a one-size-fits-all solution. It is a very American notion to think of quick ideas that will 'solve' major problems, and understandably so.
In the context of the American economy, an entrepreneurship approach makes a lot of sense. But everything is relative, and many of the issues that American entrepreneurship addresses are not as applicable to the problems of northern Uganda. The rapid prototyping model doesn't bode too well in a place with such delicate political, economic, and cultural circumstances.
Coming into the project, my collaborator, Jill, and I knew we wanted to use our combined skills (our studies in anthropology and film respectively) to tell the stories of Gulu and GWED-G (Gulu Women's Economic Development and Globalization). We hoped to understand what an investment in media and storytelling could look like, integrated into the work of a non-governmental organization in northern Uganda. But we were determined to let the unique context drive our approach: we began exclusively by listening.
For the first 10 days, we filmed in-depth, life history interviews with upwards of 45 GWED-G beneficiaries. In many ways, it was a humanistic survey of GWED-G and northern Uganda. We started with very fundamental questions like "Where were you born?" and let those questions guide us into conversations. We considered our interviewees as equal partners in building shared knowledge. And more often than not, people dove very deeply into their stories with us. During one of our first days of interviews, Pamela explained to us:
"Even if someone starts crying during their story, they still want to talk about it. They want you to know – do not let that scare you."
She was right. Almost every person we interviewed had been affected by Joseph Kony's Lord's Resistance Army (LRA), and almost every person wanted to share their story. Those days were intense, to say the least, but they allowed us to understand deeply the context and history that we were working in. After those interviews, we decided to follow the story of Samuel, a human rights volunteer who had a profound and transformative effect on his community. (More on him in future posts.)
Patience became our partner in the process. We learned to sit through silences and take as much time as needed for stories to be told, for the past to be explained. And the outcome was revelatory. We gained a complex picture of the people of northern Uganda, their history, their lives, their communities, and the impact of GWED-G's programs.
Today, we have a catalog of these stories, in addition to a longer film piece that will serve as a benchmark for what effect an organization like GWED-G can have on a community and how they do it. Through this media creation, we understood our role as tools for the people of northern Uganda to share their stories and for GWED-G to communicate its work. And our work is certainly not done.
We have only scratched the surface of what can be learned through the stories of Gulu. Design is a process-based way of working. It unfolds in unexpected ways, takes itself in unique directions while revealing things about the task at hand. This is what development work is asking to be, and in order to answer that request, the designers and media-makers who decide to work in development need to make long-term commitments. We need to let our solutions take the same course as our evolutionary design process.
Oct 31 2012
"My first job as a designer/filmmaker in the development field is to consider my approach." – yes! I love that you two went in with a solid intention behind your work to gather stories, then dove into "listening". It truly represents the kind of creative thinking artists and designers can bring to a field that, as you mention, is so dominated by the Western "quick fix" mentality – one that ignores context and takes little time to empathize with the actual issues and people involved. Nice metaphor re: the evolutionary nature of design. You bring up an important point about letting the process unfold naturally, or what could be said to be in the most humane way. Because the whole point is about changing human lives, right?
Social change is a process that needs critical, nuanced thinking both around function AND form. Something that artists and designers tend to think about on a regular basis, but few make the connection like you have. Yay you!


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Take Control Of Your Career
My husband wanted to take our daughters on a bicycle ride this afternoon within the bike trailer that we've had for years, however used just a few instances. Of course, one of many tires was flat. He tried to pump it up however it just would not hold any air, so he requested me if I knew where a motorbike store was nearby. Immediately, the identify of this bicycle shop in the city I went to college got here to thoughts because I have always thought it was probably the most clever enterprise identify ever: Cycle Path. Maybe it is simply me, but I think it's ingenious, ingenious, hilarious, and oh, so memorable. I have not lived or been anywhere close to that retailer in 17 years, but I keep in mind that name always. Now THAT'S a wise – and memorable – enterprise name!
All of the enterprise ideas … Read more


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Free Webinar Replay: Getting It Done: Tips and Tools to Help Your Child Start — and Finish — Homework
In this hour-long webinar-on-demand, learn how to end homework battles (for good!), with Leslie Josel.
Instant Access
Play this free webinar and download the slide presentation of "Getting It Done: Tips and Tools to Help Your Child Start — and Finish — Homework," plus get more strategies from ADDitude via email.
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Do you dread the nightly homework battles with your child? Are your evenings spent hovering, hand-holding, and helping your child through assignments? Do you wish he could get his work done independently — and on time — no matter what the subject? If you answered yes to any or all of these questions, you're in the right place for solutions.
Homework doesn't actually start at home. It begins at school — with copying down the assignments correctly and bringing home books and materials to complete them. Still, you can implement many strategies at home to ease the burden on you and your child. Here, we'll explore out-of-the box and creative tools your student can use to stay on task and on track, such as the "define & assign" method of planning long-term papers and projects.
Bottom line? The best homework strategy is one that taps into your child's inner strengths and needs, and provides the tools and resources needed to build executive-function muscles over time.
In this webinar, you will learn:
- How to set up your child's home environment so it engages them to get homework done
- Homework "games" your student can "play"
- How to develop a "Personal Homework Profile" to help your child learn what helps (and hinders) getting homework done
- Creative ideas for planning and working on long-term projects and assignments
- How to help your student "see" time in order to learn how to manage it
Webinar replays include:
- Slides accompanying the webinar
- Related resources from ADDitude
- Free newsletter updates about ADHD
This ADHD Experts webinar was first broadcast live on September 25, 2018.
Meet the Expert Speakers:
Leslie Josel is an academic/life coach for teens and college students with ADHD and the principal of Order Out of Chaos. She is the creator of the award-winning Academic Planner: A Tool for Time Management®, a planner that helps students develop and master time management skills, and the award-winning author of What's the Deal with Teens and Time Management (People Tested Media, 2015), a parent's guide to help teach their teens the time management skills they need to succeed. A respected resource on ADHD and executive functioning in students, Leslie speaks and conducts workshops to parent and educator groups on a variety of topics facing students today. Leslie is also a contributing writer to Family Circle magazine.
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text:
Mr Piter de Weerd, editor of Boek9.nl (Dutch) Book9.nl (English), the excellent blog about intellectual property rights in the Netherlands, pointed me to the article of
Seattle Trademark Lawyer Mr Michael Atkins, who was startled about the remedies Japan's cosmetic giant Shiseido was seeking against the Chinese users of the Shidoas trademark: damages and ... an apology.
However, in 'face saving cultures' (which include China and Japan) it is considered a punishment to have to apologise.
Although an apology is not stated as a remedy in the Chinese Trademark Law, it is in article 46 of the Chinese Copyright Law, which shows that apologies have found their place in Chinese IP law as a remedy.
Read Mr Atkins article here.


text: A trip to Rome with kids is amazing, but there is so much to see that it can be overwhelming: churches, museums, sightseeing and more sightseeing… Let's find something a bit more entertaining for kids, something educational but funny: that's exactly what Gladiator School is about! So, ready to become a gladiator for one day? Continue reading


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Troubleshooting SSIS errors can be challenging in themselves, so retrieving the correct error messages should not be, especially in time-sensitive production environments.
I am going to demonstrate how to set up and always deliver the correct, well-formatted SSIS errors when a Package fails. This may save you or anyone the trouble of digging around in Event logs and SQL Agent Jobs for the right SSIS error messages. This SSIS setup also makes you non-dependent on anyone for this information in any environment.
SSIS Error logging
SSIS errors can either be tracked using a custom logging setups or the out-of-the box logging system which can easily be configured to capture errors besides other Events. Each of these logging strategies however requires you to extract the necessary error from the logging repository after a package fails. In most cases this might require querying tables or some form of digging around to get the actual error message after it's been logged.
Using the SSIS Event Handler in addition to your logging option you can have SSIS deliver the right error details to your mailbox whenever or wherever the Package fails. I am going to use the out-of-the-box SSIS logging mechanism to demonstrate how this works. The approach I am going to describe can be used for both type of logging mentioned above, however to employ this exact approach your logging repository must be a Table.
Setting up SSIS Packages to Email Formatted Errors upon failure
Configuring a Package to email an error report anytime it fails involves 4 steps;
- Enabling Error logging on Packages and Tasks
- Creating a Stored Procedure that will retrieve and pass the error from a log table to the Database Mail System.
- Creating a SQL Task that will call the Store Procedure.
- Assigning (copying and pasting) the SQL task to any Package's Event Handler, so that anytime the Package fails it will send out an email with the specific error(s) that occurred.
Enabling SSIS logging with SQL Server log Provider
I am going to use the out-of-the box SSIS logging mechanism to demonstrate how this process works.
To set up logging, right click an empty space in your Package and click on Logging. Under Container, check the Package Container, on the Providers and log tab select SSIS log provider for SQL Server from the Provider Type drop down. Check the SSIS log provider for SQL Server and under configurations select the Connection Manager that has the database with your logging repository table. For the purposes of serving errors, make sure you enable the OnError event for the Package on the details tab as shown if fig 1 below.
Fig 1. Showing OnError Package Event.
Creating the Error Report Delivery Store procedure
The logic for the Stored Procedure that will retrieve and pass the error from the error log table to the Database Mail System is as shown in Listing 1 below.
CREATE PROCEDURE [dbo].[Htmlssiserroremail] ( @UserEmail NVARCHAR(4000), @executionid UNIQUEIDENTIFIER, @PackageName NVARCHAR(200) ) AS BEGIN SET NOCOUNT ON; DECLARE @EmailSubject NVARCHAR(2000), @executionidStr NVARCHAR(50), @HTMLContent NVARCHAR(MAX), @Query NVARCHAR(2000) SELECT @executionidStr = CONVERT(NVARCHAR(50), @executionid), @EmailSubject = @PackageName + ' Package Error'; WITH LatestRun AS (SELECT Row_number() OVER (Partition BY executionid ORDER BY id ASC ) AS ErrorOrder, s.* FROM sysssislog s WHERE event = 'OnError' AND executionid = @executionidStr), ErrorLogged AS ( SELECT ErrorOrder, computer, Operator, source, Starttime, Endtime, datacode, Message FROM LatestRun WHERE ErrorOrder < 5 ) SELECT @HTMLContent = N' ' + N'
SSIS Error Report
' + N'
' + N'
ErrorOrder	' + N'Computer	Operator	' + N'Package Name	Source Name	' + N'Start Time	End Time	' + N'Decimal Code	 Error Message	' + Cast ( ( SELECT td = el.ErrorOrder,'', td = el.computer,'', td = el.Operator,'', td =@PackageName,'', td = el.source,'', td = el.Starttime,'', td = el.Endtime,'', td = el.datacode,'', td = el.Message,'' FROM ErrorLogged AS el FOR XML PATH('tr'), TYPE ) AS NVARCHAR(MAX) ) + N'
'; EXEC msdb.dbo.Sp_send_dbmail @profile_name ='Controls', @recipients=@UserEmail, @subject = @EmailSubject, @body = @HTMLContent, @body_format = 'HTML'; END GO
The Parameterized Stored Procedure in Listing 1 above uses the current ExecutionInstanceGUID of a Package to obtain the current error(s) logged to the SSIS log table. The returned error rows are reformatted as HTML documents and then passed in conjunction with recipient(s) email addresses to the Parameterized dbo.sp_send_dbmail System Stored Procedure.
Note, sp_send_dbmail System Stored Procedure which is stored in the MSDN database and can also be configured to send an e-mail message to specified recipient(s) that may include query result set inline or file attachments, or both. I chose the option to pass the resultset as HTML documents because of the flexibility of formatting the results with various styles as shown in Listing 1.
Before you run the Stored Procedure on any Server you must however make sure that the Database Mail system is enabled on the Server. You can check-out Richard Waymire's article on how to configure Database Mail.
Remember to replace the sysssislog table in the Stored Procedure with the name of the logging table you used to setup your logging if it was different.
Creating SQL task
In this step we are going to configured the SQL Task that will execute the parameterized Stored Procedure above. In the SQL task, two System Variables and one User Variable are passed to the SP as shown in fig 2 below.
Fig 2. Showing SQL Task setup.
The User Variable must be setup at the Package scope with semicolon separated email addresses of all recipients of the error as shown in fig 3 below.
Fig 3. Showing User Email-Address Variable setup.
I normally will configure this value in a configuration file so that it is easy to change.
The two System Variables that are passed as the remaining parameters are the "ExecutionInstanceGUID" and "PackageName" as shown in fig 4 below.
Fig 4. Showing the system variables used in this proccess
Assigning SQL task to Event handler of a Package
When completed, the SQL task configured in the previous section can then be passed (copy and pasted) to the OnError Event handler of any Package to capture and email the appropriate error it to the recipients. To assign the task to the Event handler of any Package, open the Package, go to the Event handler tab on the Package, under the Executables dropdown select the Package and on the Event handler dropdown select OnError from the dropdown list. Now configure the SQL task describe above or copy and paste it in the Event Handler as shown on fig 5 below if you have already configured it elsewhere.
Just make sure any Package that is assigned this task have the UserEmail Variable.
Fig 5. Showing SQL Task assigned to an Event handler
This task will be fired at the Package level by the OnError event whenever an error occurs. The idea being that, ultimately the Package Container generates OnError event if any task on the Package Container or the Package itself errors out.
SSIS Error Email Report
Fig 6 below shows a sample error report sent to my mailbox when a Package I have configured using the steps above failed. Some stuff to note, besides font and color formatting is the ErrorOrder column on the report. Through the store procedure we created above, the report has been designed to shows the first four error messages if available, the ErrorOrder column indicate the logging order in which the errors occurred, with 1 being the first error that occurred in failed Package Execution process.
Fig 6. Showing an error Report Emailed on failure of an SSIS Package.
Many of the error messages that you may encounter may come from other components that are not directly related Integration Services components but to other components such as OLE DB providers and other database components such as the Database Engine and Analysis Services, file system, SMTP server, MSMQ and so forth. Such components generates very generic error messages when they cause a package to fail so It is good practice to retrieve more than the first error that occurred as I have done in this process. This is important because sometimes the subsequent errors may provide some information on why the non SSIS Components failed. Remember to consider subsequent errors only if the initial errors does not provide enough information.
Also on the report, the Package name is explicitly added to every row of the report even If it is a Task that failed, this information may require extra steps to obtain if you are querying the log table directly. You can use the Decimal Codes on the report to directly search for error messages here of you are not certain of the messages provided directly by SSIS.
This setup ensures that you always receive the correct error(s) and in the order which they occur with the added option of formatting the results.
In the SP, the style section allows you to format the report to your taste. I go to the extent of color formatting the reports with colors that suite my mood. I figure if you are going to recieve error messages, you might as well get it served the way you like it.


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Cdc42 is a 21.3 kDa, small GTPase protein encoded by 191 amino acids that belongs to the Rho sub-family of Ras super-family GTPases. There are two isoforms produced by alternative splicing with isoform 1 being the most commonly studied and expressed ubiquitously. Conversely, isoform 2 is restricted to the brain (also known as brain isoform, Cdc42b or G25K), but has been chosen as the 'canonical' sequence. Cdc42 switches between an active GTP-bound state and inactive GDP-bound state. This cycle is regulated by its intrinsic GTPase activity and its interaction with guanine exchange factors (GEFs) which promote the exchange of GDP for GTP and GTPase activating proteins (GAPs) which activate Cdc42's GTP hydrolysis activity. Cdc42 localizes to membranes via a post-translational C-terminal geranylgeranyl lipid modification; however, it can be found as a soluble complex association with RhoGDI (Rho GDP-dissociation inhibitor), another means of regulating Cdc42's activation. RhoGDIs sequester Cdc42-GDP in the cytoplasm through a transfer of geranylgeranyl moiety from membrane to GDI and inhibit its spontaneous GDP/GTP exchange activity. Additionally, Cdc42 can be phosphorylated by diverse kinases which regulate its interaction with RhoGDIs. To date over 70 Rho GEFs, 60 Rho GAPs and 3 RhoGDIs have been identified in mammals, reflecting the complexity of regulation of these classes of proteins.
Activation of Cdc42 is part of a signaling cascade initiated by stimulation of cell surface receptors and cell adhesion molecules which include tyrosine kinase receptors, heterodimeric G-protein-coupled receptors (GPCRs), cytokine receptors, integrins, and physical and chemical stresses. After GEF-mediated nucleotide exchange, GTP-bound Cdc42 can interact with a variety of downstream effector proteins, of which at least 23 have been identified. Putative effectors for Cdc42 include: p70 S6 kinase, MLK2 and MLK3, MEKK1 and MEKK4, PAK1, PAK2, PAK3 and PAK4, MRCKα and MRCKβ, ACK1 and ACK2, PI3K, PLD, PLC-β2, WASP and N-WASP, MSE55 and BORGs, IQGAP1 and IQGAP2, and CIP-4.
Cdc42 plays a significant role in a wide variety of cellular processes that are dependent on the actin cytoskeleton, such as cytokinesis, phagocytosis, cell migration, morphogenesis, chemotaxis, axon guidance, axon myelination, intracellular trafficking, gene transcription, cell-cycle regulation and cell fate determination. In regards to cell motility, Cdc42 is directly involved in the formation of filopodia via interactions with actin binding proteins which are nucleation factors). However, the contribution of Cdc42 in these different cellular processes could be cell-type specific. Dysregulation of Cdc42 is found in several pathogenic processes such as cancer, neurodegenerative disorders, and cardiovascular disease.
Cdc42's role in cancer is dependent on over-expression and/or over-activation rather than activating mutations. Cdc42 contributes to cancer development through defects or dysfunction in its physiological roles. For instance, alterations in Cdc42-mediated intracellular trafficking - especially through the regulation of the processing and degradation of EGF receptor, cell cycle regulation and survival, polarity, migration, and transcriptional control is related to oncogenesis. The contribution of Cdc42 to cancer progression seems to be tissue-specific since Cdc42 appears to have pro-oncogenic and anti-oncogenic properties depending on cellular context. However, there are more cell types where Cdc42 is a pro-oncogenic factor. Cdc42 protein levels are significantly elevated in breast cancer tissue vs normal tissue, testicular tumor tissue, head and neck squamous cell carcinomas, melanomas, colorectal cancer, and hepatocellular carcinoma.
Swiss 3T3 fibroblasts plated on coverslips at 1000 cells / cm2 and grown for two days in DMEM plus 10% fetal calf serum at 37°C and 5% CO2, were serum starved for 16 h in media containing 1% serum and 8 h in 0% serum media. Cultures were treated with 5 µl of CN02 per ml of medium for 10 min at 37°C. Cells were then fixed, stained with rhodamine-labeled phalloidin (Cat. # PHDR1 or BK005), and visualized by fluorescence microscopy. Images were taken at a magnification of 40×. The untreated control cells were treated with 5ul sterile PBS per ml of medium. The cells treated with CN02 produced abundant ruffles and lamellipodia whereas the control had less than 10% of CN02 levels of similar actin structures. Under similar conditions the activity of Cdc42 and Rac increased by 50 and 130% respectively as measured by the G-LISATM Activation Assays (Cat.# BK127 and BK125 resp.). A = serum starved cell, 2 s exposure; B = example Rac activation, 0.3 s exposure.
Abdul-Manan N. et al. 1999. Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature. 399, 379-383.
Abraham M.T. et al. 2001. Motility-related proteins as markers for head and neck squamous cell cancer. Laryngoscope. 111, 1285-1289.
Benitah S.A. et al. 2004. Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim. Biophys. Acta. 1705, 121-132.
Bishop A.L. and Hall A. 2000. Rho GTPases and their effector proteins. Biochem. J. 348, 241-255.
Boettner B. and Van Aelst L. 2002. The role of Rho GTPases in disease development. Gene. 286, 155-174.
Cappello S. et al. 2006. The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat. Neurosci. 9, 1099-1107.
Cerione R.A. 2004. Cdc42: new roads to travel. Trends Cell Biol. 14, 127-132.
Fritz G. et al. 2002. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br. J. Cancer. 87, 635-644.
Fritz G. et al. 1999. Rho GTPases are over-expressed in human tumors. Int. J. Cancer. 81, 682-687.
Gomez del Pulgar T. et al. 2005. In Rho GTPase expression in tumourigenesis: evidence for a significant link. Bioessays. 27, 602-613.
Gupton S.L. and Gertler F.B. 2007. Filopodia: the fingers that do the walking. Sci. STKE. 2007, re5.
Heasman S.J. and Ridley A.J. 2008. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9, 690-701.
Sinha S. and Yang W. 2008. Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal. 20, 1927-1934.
Symons M. and Settleman J. 2000. Rho family GTPases: more than simple switches. Trends Cell Biol. 10, 415-419.
Vega F.M. and Ridley A.J. 2008. Rho GTPases in cancer cell biology. FEBS Lett. 582, 2093-2101
Cdc42 Pull-down Activation Assay Biochem Kit (bead pull-down format) (Cat. # BK034)
Cdc42 G-LISA Activation Assay (Colorimetric format) (Cat. # BK127)
RhoA / Rac1 / Cdc42 Activation Assay Combo Biochem Kit (bead pull-down format) (Cat. # BK030)
RhoA / Rac1 / Cdc42 G-LISA Activation Assay Bundle 3 Kits (Cat. #BK135)
Cdc42 protein: GST tagged: human dominant negative (Cat. #C17G01)
Cdc42 protein: His tagged: human constitutively active (Cat. #C6101)
Cdc42 protein: His tagged: human wild type (Cat. #CD01)
Cdc42 protein: GSt tagged: human wid type (Cat. #CDG01)
Anti-Cdc42: mouse Mab (Cat. # ACD03)
PAK-PBD protein, GST-tagged (Cat. #PAK01)
PAK-PBD beads (binds active Rac/Cdc42 proteins) (Cat. #PAK02)
Rac/Cdc42 Activator II (Cat. #CN02)
Rho/Rac/Cdc42 Activator I (Cat. #CN04)
Spirochrome SiR-Actin Kit (Cat. #CY-SC001)
Acti-stain 488 Phalloidin (Cat. #PHDG1)
Acti-stain 555 Phalloidin (Cat. #PHDH1)
Acti-stain 670 Phalloidin (Cat. #PHDN1)


text:
my stomach is in agony
cinco de mayo is the worst holday for sensitive tums
i feel like it is full of flaming spike balls
seriously. lime juice tequila and hot hot salsa. that is all that is in there still from last night
i tried barfing but much to my annoyance i never learned how to make myself barf
or as kembra would phrase it, i never learned to "do bulimia"
i got this art in the mail
you should buy some too
this guy Yuichi Yokoyama is so awesome
buy yours here
the secret is out on Yokoyama
why is this on the wall of the new Duane Reade?
i will use this quote when i have to defend New York Minute to critics
what else is going on in my iphoto
walking home yesterday with the now-painful bags of limes and grapefruits
cuttin up fruits
boiling green tomatoes and tomatillos and jalapenos
oh im in even more agony looking at this
this industrial size cuisinart is the best, thanks sean!
i'm gonna be eating fucking green death salsa for weeks
we had some people over even though we tried to cancel our party due to inclement weather
i tried to print out sheets about the history of cinco de mayo but patrick shamed me into not doing that
everyone knows that it is not mexican independance day right
that is about all you need to know
this is patrick with my hair
this is me facinated with what i thought were "zombie packman" on naomi's skirt
did i mention the Montana guy came to our party? all the boys wanted to impress him
this is this morning
also this mornin
setting up Jonathan Borofsky
met a-ron in the part to talk about New York Minute
pupil check
just kidding
caught with the meat in his mouth
alex made a nice drawing for Secret
the fires of hell
i'm hopping in them!


text:
It's that time of year when many of us are looking for unique and useful gifts for those we love. You're in the right place! My knit and crochet creations are lovingly handmade using the finest yarns and with great attention to detail. Most are one-of-a-kind so you'll be sure that it will be special.
This week I have three great offers for Cyber Week. Just pop on over to my Etsy shop. When you check out, add in one of these sales codes depending on how many items you are purchasing.
Buy 1 item use code: CYBER10 to get 10% off
Buy 2 items use code: CYBER15 to get 15% off
Buy 3 items use code: CYBER20 to get 20% off
Thank you for viewing and shopping at my "local" online store!
If you see anything below that is not already listed on my Etsy Shop, you can contact me here or on Facebook with the one you would like to buy or have questions about.
Thank you!
And may this holiday season of lights be warm and full of love for you!
Below are several pictures of items I have for sale. There are many more than this though so be sure to view my online shop!
Selection of Cowls and Neckwarmers and Headbands:
Selection of texting fingerless mitts:
Selection of hats and neckwarmer/cowls.
Rainbow Serene Shawl crocheted in premium cottom blend yarn:
Trendy cuff / bracelets. Appliques such as hearts can be attached or detached. Contact me if interested.
Aloha Cowl – ultrasoft wool blend yarn:
Seaside Lacy Cropped Shrug – handmade crochet:
Katniss Cowl and Vest – handmade crochet:
Messy Bun / Ponytail Hat in soft warm wool blend yarn (multiple colors available):
Oceans of Love Cowl – lightweight and warm preium wool:
Diamond Cable Texting Mitts – hand made crochet:
Peek-A-Boo Messy Bun/ Ponytail Hat:


text:
self reflection
Learn more about other poetry terms
the swipe of the yellow card blurs the transition between the outside to the underneath yellow lines separate commuters from the slick metal torpedoes they await
Is it true what they say? When you love deep, deeper than the oceans,
Who AM I?? I am to help you wIth the neglect abandonment all the tears wept I came to you as they went I remember you when you fIrst began alone you crIed starved
I felt your judgment as you stared at me Blatant disgust at my wisps of colored hair And with those lipstick caked lips, you declared your decree
I felt your judgment as you stared at me Blatant disgust at my wisps of colored hair And with those lipstick caked lips, you declared your decree
I lay in silenceBreath heldstaring at a night skyTrying to grasp the depthOf what I'm looking atThe path before meClearly lit by the light from the moon...
My demons like to come out and play Don't worry they won't bother you they are only after me In fact let them braid your hair, they are great at that Do you need your make up done, they have that down pact
You were so quiet before. A meek, fragile sort. Your art was never seen by other eyes You thought they'd think you were telling lies.
Fear is a tool unlike any other, Dangerous and lively like fire, A double-edged sword, a friend and a foe; Mysterious and fearsome to think about, to feel, The thoughts entrancing the mind, able to eradicate
What do you see when you look into the mirror? Do you see a face of grace or the belief of grief? Do you see a bless of sucsess or a complete defeat? When a girl looks into the mirror, She sees fat,
What do you see when you look into the mirror?
What did poetry teach me? In all honesty it has taught me how to love myself. Poetry has taught me to honor the people that have forgotten me and to move on from a boy who will never love me.
When do you feel the most free? "When I am alone" What do you do when you are alone "Ya know, the usual… I read, maybe dance, I writ...:"
I learn who people are by how they read my poetry, The people who reach into emotionless words and drag the sounds out into a tragic tale
Remember that monster under my bed, Claws like a lion and six eyes on its head. That old monster creeping beneath me Always making me shout for my dad to go see. That monster who never did one bad thing to me,
I live in a constant paradox, where in my happiest times, I am the saddest and in my saddest times, I am the happiest. The constant contradiction that I live in constricts me in a wide open cell.
Subtract from these 20 years,Those that I swallowed without tasting-Anesthetize the clocks,Sprinkle Father Time with amnesia,Whisper the year 2011,I am 13 again-
Dear Happiness, Please don't ever leave me. I wish to be hand-in-hand with you until the end. Continue to spread your wings and soar to unreachable heights. Dear Anxiety,
My legs crossed themselves together as the sharp pieces of grass scratched against my limbs. The cooling air passing against me sent a deep chill throughout my relaxed presence.
Dear empty bottle of Elmer's Glue, You are finally empty. I have had one bottle of Elmer's Glue since I first purchased a bottle for kindergarten,
Dear Girl in the Mirror, You look back at me with cold dead eyes. You reflect everything that I don't want to see, You watch at I fuss with my hair, Apply layer after layer of makeup,
Dear Anxiety,
I am meA human being, he made me beIn this world I play the game of lifeNot as easy as the board game, but that's alright
A part of me feels guilty.
My nose becomes a leaky faucet whenever I eat soup. The bed must be remade each day because I sleep so wildly. My breasts are a treasure trove
"My, has your beauty disintegrated! Where is your heart? Is it broken? Did the devil's words abduct your love? Questionative, you may ask, not at all
I smile at myself in the mirror and it all seems a little bit clearer My reflection has grown to an uncharted zone and it all seems a little bit queerer But queer is the funniest word
January. "New year, new me." I said. Week one, "Please get better." Week two, "Don't talk to me anymore." Week three,
I started the year with a happy and full heart. I fell in love with a boy who was there from the start. We were inseparable and over the moon. I knew what love meant and wished it wouldn't end soon.
I tell the jokes that no one wants to hear, I'm the loner in a crowd. My mind is sharp but my words are dull For you can never hear a sound.
I feel stuck, sometimes Bewteen the screen and the road and my spiraling thoughts. And weak, sometimes, When I let them drink me in and drown my chest in pain, riddled with bullets I've never felt.
Look upThe sky is EndlessYou are the sky Look downThe earth is StrongYou are the earth Look forwardThe future is BrightYou are the future Now look backThe past is DarkBut you are not the past You are EndlessYou are StrongYou are Bright You are Eve
Grass is greenier with bumble bees Depression goes away with some Hennessey Bonnie and Clyde were together to the very end You don't even want to be my friend The alcohol and drugs don't mean a thing
Normal 0 false false false EN-US X-NONE X-NONE
When I write, I see me The true me, the real me I don't see a writer with a pen and paper I see Van Gogh with painting a self portrait Or a young girl with no makeup looking in the mirror
If it were offered, A real second chance, Would you sign on, For a backward glance? To correct your errors, Clean up the mistakes, To avoid the costly pitfalls, Every one of us makes?
we tread lightly,
I stand upon a Cliffside, Watching the hard white waves stride. When I hear someone call me from my side; I turn and meet a glare with their sunset eyes. They cast my gaze to a valley side,
Sometimes I like to think about trivial things
It was so fast passed me so fast I didn't realize what I had till it just washed all away it was so fast just so very fast life experiences intangibly slipping away but that is okay
at the bottom of the whole mind, I walk there sometimes, with a sense of at ease instilled in my spirit. With old brown boots and a ragged plaid shirt, I am here uncovered and old.
Rambling is a nasty habit
Life is an enigma, That can't be understood, Too many pieces lost in time, Like puzzle pieces scattered in the air, Emotions running high, The tears begin to fall,
Here, nature grasped me in her arms and straddled my front. Here, she immersed me in her smells and her soft, lingering caresses, Here, she dominated with gentle, sudden, adamant will power.
Seldom I will show you, I think that I am not good I just hide things
I am the daughter of Celine and Jeffrey I am the sister of Kenneth I am the best friend of Jeslyn I am a resident of Orange County I am a student of Northwood High School I am a victim of self harm
The girl looks at her own reflection Wondering if she's going in the right direction Life seems so confusing and often bittersweet She wonders what she can say when it's all complete
there's a girl who's always been inside of me. I sometimes glimpse her in the mirror, in puddles and compacts and display windows. She's the kind of girl who writes secrets in the night sky,
Torn as I live here, from day to day. I look back on, the life I once lived today. Only to realize, how far I'd fallen astray. Reality is, to me a constant enemy. Despite my attempt, to break free from these chains.
You'll never fit in; You'll never be one of us. Put your hand down, You're not that smart. You confuse the senses -- Your exterior hard; your skin soft. Your face harsh; your voice smooth.


text:
On the Train
You're on a train. You know you won't make it to your next bus on time but still you have some hope. When you get off the train you'll run up the escalator and cross the road to the bus stop and most likely find the stop devoid of people. But by some chance the bus may be late. The train slows into the station. It stops. You're on the first carriage but you don't realise that the train hasn't gone to the end of the platform. There's another boy in the carriage and he rises to get off too. The doors don't open. There's a button that says press when lit. It's not lit but you're both wondering why the doors aren't opening automatically and he presses it anyway. A couple more presses and you exchange a glance. You try and look through the clear doors to see if anyone else is getting off but no one seems to be.
You don't know how he guessed it but you hear him mumble something and ask him to repeat. I think someone's fallen. A thud comes over you. A man on the platform looks in and you see a hand slice across his throat. Then you see the woman. Her body is bent over and when she pulls herself up you see the distraught face. People are around her and you don't know if they know her but one's got their arms around her and another's giving her water.
You exchange some words with the boy about how you wish you could get off. You've sat down and you feel yourself shaking. You almost want to cry, but you know you won't for this stranger. Your mind twists and turns and you pray and beg and hope that somehow they're alive. The PA crackles and the announcer comes on. Someone has jumped in front of the train. We need to wait for the police to arrive before further action. It's honest. A few people have moved up into the front of the carriage and are peering out. On the platform the train workers seem to be walking just past your carriage and looking down. They're under there, they could be under you. You can't help thinking of a body squished beneath your feet. People who must have been waiting for trains seem to be trying to gain a peek from a distance and you wonder about that morbid fascination. What can they see? But you think you'd rather not look. You shake.
You wonder what other people are thinking, but none appear to be worried. You feel like you shouldn't feel anything, that the only thing you have a right to feel is annoyance for the delay. You don't know this person; you have no right to feel pity.
You don't know how it happened, you can't even begin to comprehend how, but you hear the words, and they're alive. You look up, out the window and there's a woman being held by police. She's covered in dark shades of dirt but the first thing you notice is how her hair isn't that messed up. You smile. You smile and look at the boy and you can't help but mutter that's amazing. You get up but don't know why and sit back down and smile and pray that she'll be alright. She sits rights outside your window and you can look at her easily. You wonder.
The announcer comes back on and you're being ushered to the front of the train where you go through the controller's room and onto the platform. Despite the racing thoughts you can't help but take a glance at the controls and realise you've never seen them before. You stop for a moment on the platform and look towards the woman who's now surrounded. You wonder. The boy has ended up behind you and you have one last mumbled glance with him and then you're off. Pushing through the crowded, staring platform and down the stairs, where you dip your ticket and stand, unrushed on the escalator. You pray and hope and wonder about strangers and miracles.
Sirens are filling the air and you know where they're going. And then you smile, and walk slowly to the bus stop where you wait, knowing you never would caught the first one anyway.
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