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Create a Website Account - Manage notification subscriptions, save form progress and more.
Residents can schedule a visit with the Home Energy Squad to review ways to improve your home's efficiency and save money. Learn more on the Home Energy Squad website.
The City of Hopkins is a proud participant of MinnPACE. PACE financing (Property Assessed Clean Energy) is making energy efficiency upgrades and renewable energy investments more attainable to commercial building owners. MinnPACE is a fit for most industries including farms, commercial office buildings, nonprofit organizations (including places of worship), and multi-tenant buildings. Common investments include solar panels, HVAC systems, lighting, motors, and more. Learn more about the MinnPACE program in Hopkins.
Residents and businesses can learn more about efficiency programs and rebates opportunities through Xcel Energy and CenterPoint Energy programs.
There are many ways that you as a consumer can reduce the amount of garbage you generate. Many of them are not difficult and do not cost extra money-in fact, they may even save you money.
Keeping our water quality clean is a top priority for the city. Learn more about water quality and help us protect stormwater quality and report illegal dumping.
Want to learn more about how to conserve water? Read 20 Ways to Save water.


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Sometimes I peek into the hashtag #doodlersanonymous on instagram just to see what kind of trouble doodle addicts are cooking up. In today's case, @nothingwolf's Inktober series that he has been sharing on our hashtag got me really excited. The artist is Federico Tobon, who also goes as wolfCat. Diverse lines vary between thick black or fine dotting, the strong alongside the delicate in mysterious harmony. The symmetry of simple shapes form compelling compositions that naturally pull your eyes toward the peak of their design. I enjoyed his series of doodles on sheet music, with crazy characters creating chaos over the orderly notes. Clearly, wolfCat is not one to follow the rules and the results are nothing short of mystical.
Doodling the Mystical
Posted by Jaanelle Yee
• October 12, 2015

subset: commoncrawl


text: Susan Greenberg, age 44, of Chicago, accomplished photographer and artist, beloved partner of Lurrie Bell; loving mother of Aria and the late Elijah and Corrina; devoted daughter of Judith and Aubrey Greenberg; cherished sister of Jessica (Eric) Bruozis and Georgia (Robert Goldsmith) Greenberg; treasured aunt of Justin, Emily, Isabel, Joshua and Noah. The family is extremely grateful for the love and care Susan received from her extended family and many friends. Service Wednesday, 11 a.m. at Chicago Sinai Congregation, 15 W. Delaware Place, Chicago. Interment private. In lieu of flowers, contributions to the Northwestern Memorial Foundation, in support of the Renee Schine Crown Neonatal Intensive Care Unit (in memory of Elijah and Corrina), 676 N. St. Clair, Suite 2050, Chicago, IL 60611 or Horizon Hospice, 833 N. Chicago Ave, Chicago, IL 60622. For condolence info, The Goldman Funeral Group, Irwin Goldman Funeral Director, 847-478-1600.


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Monday November 2, 2015
on my facebook wall, a photo of a castle in England belong to LORD LOVELL...Blowfish should claim it, by Manifest Destiny! (Dictators album via James Monroe and DO see the Monroe museum in Fredericksburg, virginny; yet another Virginny-born Scottish-American president, like I should be, though "I wanna be REFLECTED!
Tuesday November 3 2015
Bruce Arnold-Orpheus asked me "like" the Orpheus page and it IS a trip down memory lane; vietnam raging, but flower-power music...it could happen today! so like/friend Bruce and/or band, read an aj wachtel noise article and they seem like nice guys! even if "well, we were on MGM 40 years ago"; none o' THAT rock-star snobbery that I despise!"
there IS a figures on a beach facebook page: lotsa early '80s synth-pop/funny haircut/Spit on Sundays IN DETROIT memory lane! (especially if you know/love Fireking! check it out!)"
Wednesday November 4, 2015
from 2000 Joe Browns via village voice (NY Groupie News!) Nick Didkovsky covering PRETTIES FOR YOU album at the Stone in NYC; us Alice Highland guys only do love it to death through muscle of love, so this IS "wicked rare" as they say...so he sings "reflected" versus "elected"....and Tony Mann (NH's Flying '69, backed up GG Allin in NH! guitarist is Mrs. Muck's brother!) (that means Scorpio Linda, for Shore!) is -agoing; he ALSO have a Cooper cover band in NYC!"
Thursday November 5, 2015
sonics osmosis at out of the blue gallery; Dylan's "ballad of a thin man" plays over p.a. Become loveable Problem Child (I think) had flute/sax/free jazz/ lester bangs woulda dug it; fable grazer had two acoustic guitars, 6 and 12-string (with feedback!), hammered dulcimer, miles david trumpet, electric guitar; very MX-80, maybe and everyone played for 10 minutes with a set of lights like they use in sporting events! Forbes graham MAY have been a fellow playing Miles davis trumpet and also using noises off his computer; metal chaos ensemble had pots and pans, basoon, sax and lastly a guy drumming like mad and SCREAMING= first half-Japanese e.p.! you get the drift; they meet once a month, Out of the Blue is VERY 1975 Bloomington Indiana, there was a hippie-dippie section and again MX-80 were "progressive-art-noise" so I was having 40 years ago flashbacks! Good fun, y'all should go!"
Friday , November 6, 2015
my niece Justine is dj on Rochester NY country station WBEE;7-midnight! more famous in Rochester than ole uncle Ken, wrote some Gizmos songs in high school in Brockport NY but had to move to Indiana, just like Hendrix: Seattle-UK to get "notice"...Still I'm sad.
Saturday November 7, 2015
handymen, tavern at end of world. my table was paula and mike (stewart clan!), WMFO, Tony kacynski (figures on a beach) and drummer Matt Burns who just got out of garage-rock practice with Migeul D'Amour band The SuperKools! tongue-in-cheek and cheese factor galore.
handymen ran through top 40 hits from the punk era! ("gag me with a spoon"!) let's see: alan parson project, ABC (Tony Kaczynski opened for them in '82 with Figures on a beach; check their facebook page for more '80s nostalgia!) "the young and the restless" done Ronnie James Dio style, Chris Cote can REALLY belt out them vocals! (I had to tell Tony this was from a soap opera, so, as I DID say last night: "you know your 80s synth-pop; i know my soap operas from my mother!"). doin' that Lisa Robinson Rock Scene thang (versus "doin' that scarpyard thing" by Cream!), members of Triple Thick, the Flies and Shy Five were there; this IS a musicians band, doin' "knights in white satin" and "rebel rebel' perfectly. a tale to Matt Burns/Tony kacynski; before Streets opened it was Gladstone's and once I gazed in and a bearded band of Peter Wolf look-a-likes was playin' "turning Japanese" ('81!) they were BEGGIN' me to come in! (later that year slickee boys at streets!) I told tony, who countered with "I was in Detroit then"; figures started march '81, but me: "I was wicked wasted, came from Rat on last train"; Tony: "it must have been culture shah-k!" shock being pronounced the way I "tahk"! oh, yes "here's a shoutout to everyone from Detroit; kick out the jams, mofos!"; tony raises hand and set closes with...Bob Seger's "Hollywood nights"?!?!? I exited durin' Nicolette Larson's :"gonna take a lotta love", which DID outsell Hello World in '79! (or Tony's 1979 Devo-ish demo with Rick Rolski, whom went on to be Keith Richard in the Darlings). 0100....tyme for Coast to Coast AM!"...."....
Sunday November 8, 2015
I strolled to Faneuil Hall through Haymarket singing "lonely financial zone" and "government center"; am I now KENNETHEN Richman? hardrock café, greg allen's fringe religion 8 pm. did a Korps gig last year cantab but let me say: great pop toons, great guitars, a bit of cheap trick 1979, slower toons kinda 1979 tom petty (or is this the same who/kinks/byrds riffs that= Real Kids Red star album?) but also in that what WAS I lissenin' to in 1978 feel was dictators "stay with me" and johnny burnette's "lonesome train" (BUT had Robert Gordon/link wray fresh fish special, laurel Md. '78, so...)....catch Greg Allen while you can before I do Ken Highland's Fringe Religion! (watch youtube of me as Roky Erikson with triple thick and the southern Baptist Black Oak, arkansas feel is THERE!).
so greg open for a Who tribute band and all "my people"= Gee Julie and WMFO's Paula! set list:(have copy! plus guitar picks!): who are you/cant explain/kids are alright ("Pete" had 5 guitars, used Rickenbacker on last two!)/you better you bet/baba o'riley/my wife (bassist was dressed in fine foppery, scarf, no "bippity-boppery hat" though, POGOed (Moon was kinda sedate) and could outplay Carl Biancucci with one finger!)/behind blue eyes/eminence front/join together/squeeze box/pinball wizard/see me feel me/5.15/my generation/shakin' all over/wont sound like the Jumper Cables again. (can you spot the lick I stole for "kielbasa"?). folks followed these guys from BUFFALO, so I got a response to "Go Bills!" (playing Miami 1pm!). Gee Julie and Paula were "dancing fools"; Paula claims she saw Tommy 37 tymes (Ken Russell movie) and she DID do daltry's walking movements! we got the bum's rush at 11 pm, despite tales of Paula knocking out GG Allin, then in bar part, Ken/GeeJulie/Paula all dancing to Dee-Lite's "groove is in the heart"; we ALMOST went to Machine for HEROES to "keep on dancin'"; Julie and Paula were both Elton john fans (teeny-boppers! switched from Elton '73 to JOBRIATH '74 to Gene Dante 2014!) so "Saturday night's alright for"...DANCIN'! maybe the handymen might cover some Elton..can't get ABC out of my head!".


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This article was originally published by Rhoda Wilson at The Daily Exposé.
Yesterday, World Health Organisation Director-General Tedros Adhanom Ghebreyesus announced "with great pleasure" a joint project of the IPU Parliament and WHO, "which can guide parliamentarians along the path towards health for all, including on law-making, finance, taxation, and accountability."
A few days ago, we published an article warning that the World Health Organisation ("WHO") aims to begin installing a One World Government under the guise of global health security. If you didn't believe us then, this latest development should convince you now.
IPU Parliament claims to "empower parliaments and parliamentarians to promote peace, democracy, and sustainable development." Out of 190 parliaments in the world, 178 national parliaments are members of IPU. The Inter-Parliamentary Union ("IPU") began in 1889 by Englishman William Randal Cremer and Frenchman Frédéric Passy. You can read more about the history of IPU HERE.
And WHO is a private organization, a puppet organization that is funded by Globalist billionaires. Bill Gates, along with the organizations he controls, is, by far, the largest financial contributor to WHO. Only 13% of WHO's budget comes from assessed contributions, which are set amounts paid by member-state governments.
All parliamentarians who want to protect citizens and their nations' sovereignty, freedom, and rights from these want-to-be global dictators should be calling for their governments to stop funding and exit the WHO. Any who aren't, by default, are identifying themselves as Globalists and puppets of the planned One World Government.
Some have been already calling to #ExitTheWHO – based on the secretive negotiations taking place regarding amendments to the international health regulations and a proposed "pandemic treaty" – but this latest development should leave no one in any doubt of the dictators at WHO's intentions. All parliamentarians and all citizens of all nations need to join the calls to put an end to the Globalists' dystopian dreams of a one-world totalitarian state which is under the rule of a very few.
Over the past two weeks, the US and other members of WHO have been negotiating ways to give sweeping new powers to WHO's Director-General. Through material changes to existing international health regulations and/or a new pandemic accord, Tedros Adhanom Ghebreyesus would be able to declare actual or potential "public health emergencies of international concern" in any country based on privately supplied information and without the agreement of the nation(s) affected. Worse yet, he can unilaterally dictate what must be done in response.
The idea of granting WHO and its leadership such potentially fraught authorities is all the more problematic in light of their imperious, and malfeasant, conduct at the direction of the Chinese Communist Party ("CCP") in the course of the covid-19 pandemic. But, the approval of one or both of these agreements is likely – all other things being equal – to happen when the World Health Assembly meets in May 2023. The new WHO authorities would become provisionally binding on member states, irrespective of whether or not they ultimately endorse them.
Especially troubling is the convergence of these initiatives with measures promoted by WHO to institute global digital identity cards to document and monitor vaccination status and other medical conditions. When combined with the proliferating introduction of central bank digital currencies ("CBDCs"), these "smart" IDs would facilitate efforts to monitor, control and enforce WHO's diktats, and punish those who defy them.
Below is an easy-to-digest webinar describing the WEF-WHO-CCP power grab and the imminent threat to our country and our sovereignty. The webinar, hosted by the Committee on the Present Danger: China, covers the nature of WHO, the CCP as the dominant force at WHO, and the consequences of the adoption of the China model. A copy of the transcript can be found HERE.
If the video above is removed from YouTube you can watch it on Rumble HERE.


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It was August 20,2020
Yes, it was a 20-20-20 day.
Physics One is now for sale, paperback, for under $20. For the last year and a third I've been working on physics writing, notably Physics One and a review volume on computer simulations of polymer dynamics, so the gears have to shift a bit before the pace picks up.
I am also working on a volume listing of board games on military matters. It has some time to go.


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Happy New Year!
We hope everyone had a safe and fun New Years Eve! MCRC is going to BUSY in 2013. Keep an eye out for upcoming service projects, social events, and professional training classes. More information is coming soon!
Be Safe in the Water!
Summer weather is quickly approaching and that means many Tri-Cities residents will be heading to the pool or river for some relief from the heat. Don't forget the importance of safety in the water! Below is some helpful information on drowning. Be Safe!


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Continuing my recent obsession with food-beer pairing, I picked out a nice light wheat ale to go with a nice light quiche. I had a helluva time finding a beer that was just a wheat ale, and not apricot wheat or honey wheat or whatever the fuck else, but I managed to find Granville Island's Robson Street Hefeweizen, an unfiltered wheat ale with a pretty yellow label, deep within the bowels of the NSLC beer cooler.
I've said it before and I'll say it again - I'm not a huge fan of beers on the lighter end of the spectrum, but I needed something mild enough that it wouldn't overpower the subtle eggy-ness of the quiche. And this did the trick. As far as lighter-coloured beers go, this is not bad. It's unfiltered so it's a little on the cloudy side and neither as fizzy or yeasty as I would have expected from looking at it, which I like a lot. It's got some slightly fruity elements but not enough to bother me, and it goes down pretty smooth which is nice.
I don't feel strongly about this beer either way to be truthful. It did the trick with the quiche - otherwise it's a very inoffensive beer which I wouldn't go out of my way to drink if it was handed to me, but wouldn't likely buy again.
Granville Island Brewing is based in Vancouver. Their website is here.


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|President Nixon's 1973 Inaugural ball at the Museum
of History and Technology, January 20, 1973,
by Richard K. Hofmeister, Smithsonian Institution
Archives, Record Unit 285, Box 10,
Folder: 11, 73-518-14A or SIA73-518-14A.
One particularly memorable experience occurred on January 20, 1973, as President Richard Nixon attended several official inaugural balls, including one at the Smithsonian's Museum of History and Technology (now the National Museum of American History). Over seven thousand people, dressed in fine feather, filled the museum to celebrate. Lines were out the door, and the crowds had nowhere to dance. Despite the confusion and heat the room had a celebratory air and guests were excited to see the man of the hour.
|Chicken that disrupted President Nixon's 1973 Inaugural ball,
January 20, 1973, by Unknown, Smithsonian Institution Archives,
Record Unit 285, Box 10, Folder 12, SIA2009-0415 and 73-688-22A.
The chicken, along with a few other fellow fowls, took up residence in the museum in 1969 to give a sense of realism to the American farm life exhibit. The birds lived in the exhibit and according to museum staff, were usually quite docile. However, this little chicken must have had political ambitions and decided crossing the exhibit road to participate in the inaugural ball would be a fun adventure. Secretary Ripley remarked that the incident was "a real chicken caper" that certainly added to the excitement of the night. Once again, a visit to the Smithsonian, whether a school trip or an inaugural ball, proved to be a unique adventure.
Courtney Bellizzi, Smithsonian Institution Archives


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Note: This post contains affiliate links. If you click on them you'll be taken to a website where you can purchase the Harvest Your Health E-Book bundle. I'll make a commission for each purchase. Thanks in advance for your support! Read more about the bundle below or click here to learn more: https://www.e-junkie.com/ecom/gb.php?cl=164463&c=ib&aff=258368
How was your weekend? Mine was pretty great. We had tons of family time celebrating my oldest's 4th birthday. So hard to believe I've been this guy's mommy for 4 years!
I made a really yummy strawberry cake - I will have that recipe up soon.
I also wanted to let you know about an EPIC ebook sale going on right now. When I first came across this bundle, there were so many I wanted to read for myself so I figured it would be a great sale to share with you - my wonderful readers! The topics include cooking, personal care, nutrition, parenting, fitness, and many more. You have to check out this amazing list of ebooks, there is something for everyone!
Autumn has arrived in full force while the team at Primal Toad was busy harvesting the best collection of health and wellness eBooks to share with you all. Including 65 unique authors, The Harvest Your Health Bundle is sure to bring a bounty of inspirational wellness wisdom to you this fall season.
Your health is important to us, so we wanted this bundle to be affordable for everyone. For one week only, this incredible collection is available for 97% off retail value! You pay just $37!
The following is the list of all the eBooks, meal plans, online magazine subscriptions and discount codes included in this once in a lifetime offer.
Don't miss out on this amazing opportunity! I will be posting some reviews throughout the week as well to give you an idea of what you get from this HUGE ebook bundle.


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As the weather turns cooler, and the leaves crunch beneath your feet thoughts often stray to hearty stews, cozy fires, and good company sharing a delightful libation. Fall often evinces thoughts like this, inspired no doubt by the splendor of the season, and the crisp breeze carrying the scent of autumn through the air. I find that I become more selective with regard to the beverages chosen to mark the season, and those moments that take on a greater significance. Many people intentionally pair their beer with the evening's planned victuals, and often do so with painstaking precision. I am perhaps not that particular, but I do enjoy the process of merging flavors in a way that elicits the best qualities of both the food and accompanying brew. What I have more recently taken note of is the story behind both, and how much that factors into my decision.
Cooking heals, and the process has an almost meditative power. Selecting a recipe is more than meeting a list of dietary restrictions, and flavor preferences; it also involves the history of the dish. How, why, and for whom was it created? Granted there are not always answers to these questions, but it certainly is intriguing to embark on the voyage to uncover them. The national dish of Cuba, Ropa Vieja is a perfect example of this. Legend has it that a peasant had no meat to feed his family, so he decided to take his old clothes and put them in the stew pot. While it cooked, he thought about how much he loved his family. When he uncovered the stew, the threadbare garments magically transformed into the delicious shredded beef stew (resembling tattered clothing.) Miracles, inspired by love, created this dish. Fanciful? Perhaps. Delicious? Definitely!
This wee tale leads me back to the accompanying beverage. What inspired a brewer to make a particular beer? Was it love? Was it history? Was it something more? Not all brewers share the muse behind the conception of a brew, but when they do I find myself intrigued and more inclined to give it a go. Make no mistake, a well told story behind a creation will not make up for lack of quality, or cleanliness in the process. Will consumers select beers with no significant story? Absolutely- if they are well crafted. Often however, one can tell when a brew was uninspired, as it shows on the palate. Similarly, a thirsty connoisseur of malted beverages can taste the inspiration behind it. Brewer's Alley Wedding Alt is an example of an extremely well-crafted alt beer with an equally inspired story. Brewer Tom Flores created this very personal beer to mark the most auspicious occasion of his very own wedding. It was brilliant, and so well received that it became an (annual) seasonal offering, much in demand.
Other breweries in Maryland have also created beers motivated by personal stories, or historical events; just take a gander at Union Craft Brewing's Duckpin Pale Ale. Duckpin bowling was invented in Baltimore, and neared the point of extinction (if you can use that terminology for a dying sport) when Union Craft released their homage to the Baltimore institution. The sport was invented around 1900 by a couple of Baltimore Orioles Hall of Famers while drinking beer in a billiards hall (although the specifics of this are open to historical debate.) Union wanted to get in touch with what made Baltimore great, and its rich history of craft brewing was a perfect analogy to the once thriving sport of Duckpin bowling. The sport and the beer have both surged in the past five years, and it would be impossible to separate the revival of one from the success of the other!
To have a muse behind the crafting of a fantastic beer may not be a significant factor to some consumers, but for many it will most assuridly lure them to open their wallets and give it a try!
Beer for thought!


text: FOODChristmas Cocktail Recipes for the Holidays (16 Infographics) Viki B 23 Dec 20209. Christmas Alcoholic Bourbon Drink Recipes 1. Christmas Cocktail Recipes for the Holidays (16 Infographics)2. The Ultimate Christmas Cocktails3. 12 Drinks of Christmas4. Christmas Drinks from Around the World5. Christmas Wine Cocktails Around the World6. 20 Christmas Cocktail Recipes to Try Out at Holiday Parties7. Sous Vide Christmas Drinks8. 10 Delicious Christmas Cocktails9. Christmas Alcoholic Bourbon Drink Recipes10. Michaels Top 5 Holiday Cocktails11. 6 Seasonal Drinks for a Flavorpul Christmas Party12. Retro Style Christmas Cocktail13. 6 Christmas Drinks14. Hops for The Holidays15. 15 Champagne Cocktails16. Whisky Cocktails Please rate this article☆☆☆☆☆ Share on Facebook Share on Twitter Tags: Christmas coctailscocktailsinfographicsHomeFoodChristmas Cocktail Recipes for the Holidays (16 Infographics) 28 Infographics that Can Help You Prepare for Chri... 30 Infographics About Cakes Every Baker Will Love CommentsClick here to cancel reply. Name Email (will not be published) Comment Related Food Articles Recipe For Strawberry Mint Spritzer Recipe For Cranberry Pomegranate Champagne Sparkler 22 Infographics for Avocado Lovers Everything You Need to Know About Bread (18 Infographics) Stupid-Easy Recipe for Whole Strawberry Margarita (K400) (#1 Top-Rated) 16 Infographics About Burgers


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Laxman, a boy from a village in Tamil Nadu, sets off on a Sunday morning on his bullock-cart, to collect bales of freshly cut hay. The author vividly describes the journey to the fields, so much so that one almost begins to experience it - the thudding of the animals hooves on the dirt road, the tinkling of their bells and the chaotic traffic! However, the chaotic traffic poses quite a challenge to Laxman and his bullocks, as people 'never seem to realize that a bullock cart has no brakes!'
On the way, Laxman greets all his favourite flowering trees, the birds that sing, as well as those that soar. And as, he watches them his mind is full of questions. However, no one seems to understand him, except his grandmother. She tells him,that it was alright to ask them for asking, "questions are as important as the answers".
The story not only provides us a glimpse into the life of life a village boy but also sends two strong underlying messages - one is to appreciate the gifts of nature and second, not to hesitate to ask questions. Even when there seems to be no answer to them. Borrowing from the words on a popular advertisement 'Questions achhe hote hai!
Vivid illustrations with a lot of details for children to discover, add to the appeal of the book.


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Photographs courtesy of Farms for Orphans.
Farms for Orphans (FFO), a nonprofit based in Colorado, is working to establish sustainable food sources for children and orphans in the Democratic Republic of Congo (DRC) through investments in insect farming. According to the U.N. Food and Agriculture Organization (FAO), insect farming has a variety of benefits, including less land use and lower levels of greenhouse gas emissions compared to traditional animal-rearing. Additionally, insects are an excellent source of micronutrients, particularly copper, magnesium, and zinc in which they are high.
FFO is initiating insect farming for communities in the DRC by building the agricultural infrastructure, hiring support staff, and engaging community members in their mission to ensure orphaned and underprivileged children have a sustainable source of nourishment.
Food Tank spoke with Amy Franklin, Farms for Orphans Founder and President, to learn more about their current work teaching DRC communities about insect farming and their aspirations for the program.
Food Tank (FT): What was the inspiration behind starting Farms for Orphans?
Amy Franklin (AF): My children are my inspiration! In 2013, my husband and I adopted two of our children from the DRC. Our kids, like millions around the world, suffered from malnutrition. Today, they are happy, healthy, and thriving! Unfortunately, there are millions of orphaned children around the globe that are unable to reach their full potential or live productive lives due to malnutrition.
The fact is, problems that stem from malnutrition such as stunted growth, impaired cognitive development, compromised immune function, and lost productivity exacerbate many of life's existing challenges. Malnutrition is often described as one of the biggest missed opportunities in global health. We believe that addressing malnutrition in children can facilitate critical improvements in health, educational attainment, economic productivity, and quality of life.
Knowing these statistics and watching my kids grow and blossom over the years motivated me to help other orphaned children access the nutrients they need to survive and thrive. In 2015, Farms for Orphans was born.
FT: How are the various problems addressed by Farms for Orphans connected?
AF: Farms for Orphans works in collaborative partnerships with orphanages to implement insect farming on their grounds to provide a healthy and sustainable source of protein, fat, and micronutrients for the children in their care. Once the orphanages are successfully farming insects, we work with them to help maximize the economic potential of their insect farms to combat the general poverty of the orphanages. Orphanages in the DRC receive little-to-no government support or outside sponsorship. We have found that a small-scale insect farm can earn approximately US$300 per month, and the additional income can be spent on nutritious food or school fees for the children.
Further, our program is designed to engage youth in the farming process to help them build marketable skills. By addressing malnutrition and poverty, while also providing vocational training, we hope to change the lives of these children.
FT: How does your programming change in the communities you are working with?
AF: We believe insect farming can improve the lives of orphans in three key ways. First, our program will improve their health through the direct consumption of nutrient rich insects. Second, orphanages can achieve economic autonomy through the sale of farmed insects at market and use the additional income to purchase fruits, vegetables, and other proteins. Finally, youth who learn the insect farming process will have the skills to begin their own farms, allowing them to support themselves as adults, and make positive contributions to their communities. Additionally, we hope to see decreases in stunting and increases in child morphometrics (i.e. height/age, weight/age, and weight/height). We also hope to see decreases in iron deficiency, anemia, and micronutrient and vitamin deficiencies as insects are rich sources of iron, magnesium, calcium, potassium, and fat-soluble vitamins. With improved nutrition, children have an increased likelihood of accessing education and growing into healthy adults.
FT: Why do you concentrate on insect agriculture?
AF: As a veterinarian, my original vision for FFO was to train orphanages to raise traditional sources of protein such as poultry or goats. I quickly learned that most orphanages, particularly those in large African cities, do not own land and may have limited access to water, which are both essential to raising traditional livestock.
Prior to this endeavor, I was unaware that two billion people around the world ate insects on a regular basis! Through my research, I learned that insects were a popular food source throughout the developing world, including the DRC. As I considered feasible options, insect farming made the most sense from both economic and environmental standpoints.
Insects are easy to farm with minimal capital investment and require only a fraction of the natural resources needed to raise traditional livestock to produce equivalent amounts of protein.
FT: Why did you select the Democratic Republic of Congo for your project location?
AF: The DRC is the birthplace of two of my children, and I feel a personal connection to this country through them. Additionally, the DRC is one of the world's hungriest countries and the situation is particularly dire for the country's orphaned children, which number over four million. Furthermore, recent declines in foreign aid to support humanitarian assistance combined with low levels of government spending on socio-economic sectors such as education, health, infrastructure, and agriculture has further undermined food security and nutrition in the DRC.
Our first goal is to support the orphanages where my children are from in central DRC. FFO plans to expand insect farming operations to central and eastern DRC as soon as we can safely travel to the regions, which are currently enmeshed in significant social conflict. Once we are operating there, we expect to be able to expand further.
FT: Farms for Orphans is currently building out its agricultural infrastructure. What challenges have you faced as you build out those systems?
AF: The biggest challenge we face working in the DRC is the lack of a functioning government. The current president, Joseph Kabila, has refused to leave office after his mandated two-term limit ended in 2016, resulting in political turmoil and impending threat of civil war. Further, the lack of basic infrastructure in the country makes travel and, at times, communication with in-country staff difficult.
FT: What is the impact that Farms for Orphans has seen to date?
AF: FFO, in partnership with the Global Orphan Foundation, is successfully farming African palm weevil larvae in Kinshasa, DRC and have built insect farms on four orphanages, caring for a combined 1,000+ children. We have shown that farming the African palm weevil, a traditionally wild-caught food, is a viable solution for orphanages with no land and few resources to grow their own protein.
We continue to evaluate our program and expect that insect farming will improve the lives of orphans in two key ways, by decreasing hunger and improving health through the consumption of insects and by creating economic autonomy through the sale of farmed insects at market.
FT: What is Farms for Orphans excited for in the coming year?
AF: We are excited to watch the insect farms grow and see the children receive the nutrients they need to survive and thrive! In 2018, FFO and the Global Orphan Foundation will begin a study to evaluate the nutritional benefits affiliated with the addition of the larvae to the children's diet.
This coming year also brings a new partnership with Loyola University of Congo. We believe that we can impact the largest number of lives in the DRC through strong partnerships and collaborations, particularly with Congolese led institutions.
Further, FFO is eager to train more orphanages in insect farming techniques throughout the Democratic Republic of Congo and eventually, sub-Saharan Africa and beyond!


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Banana Split Cupcakes from Bakers Royale
These yummy looking banana split cupcakes from Bakers Royale are filled with a banana cream custard. Can you say YUM?
And even if you aren't a banana person you still should head over and check out her tips for decorating cupcakes with non perils. It is a life skill that everyone should have.
You can check out the recipe and her non perils techniques HERE.


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Potential cures and treatments for diseases are on the horizon for a growing number of patients, thanks to recent breakthroughs in CRISPR gene-editing technologies and in cell and gene therapy. In this webinar series, you'll hear from experts and executives from across the life science ecosystem who are poised to help transform healthcare. You'll learn how these leaders are tackling the many technical and commercial challenges in creating a fundamentally new way of treating patients.
CRISPR in the Clinic: Challenges & Opportunities
Gene editing is having a landmark year, with the recent launch of the first US clinical trial testing a CRISPR-Cas9 treatment, and a second trial set to begin later this year. Biotech and healthcare leaders are closely watching these studies to see what impact CRISPR gene-editing could have on genetic disease, and how possible safety risks, such as unintended edits, might play out in patients. In this webinar, you'll hear from top CRISPR experts in industry and academia, who will delve into the promise, and the possible pitfalls, of CRISPR-based therapeutics.
Charles Albright, Ph.D.
Chief Scientific Officer
Editas Medicine
Dr. Matthew Porteus
Stanford University
You've made the cut. Now what? Validation and applications for CRISPR-derived cells
The power of combining CRISPR modifications with the peptide tag, HiBiT, offers new applications in cellular biology, provides understanding of additional disease states and insight into the efficacy of compounds used to treat disease. Current methods of measuring protein abundance are limited due to size, high backgrounds, low sensitivity and lack of function. Often, overexpression can lead to artifacts not inherent to true protein measurements. Combining the speed and simplicity of CRISPR with the versatility and sensitivity of HiBiT allows for the measurement of protein expression at endogenous levels, making HiBiT well suited for CRISPR-mediated genome editing. Here, we will discuss applications for the generation of HiBiT CRISPR workflows, and the genetic characterization of HiBiT clones, stable pools and cell lines.
Marie Schwinn, Ph.D.
Senior Research Scientist II
Advanced Technologies Group


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Eric Crowley wrote the post "The Most Abominable Christian Wife on the Internet" about Jenny Erikson in 2013.
Dalrock has written. about Jenny Erikson 13 times.
In 2014, her ex-husband Leif Erikson tweeted
(and got a response from Rollo Tomassi)
Btw…this whole divorce process sucks. Plus, once you wade through it all then there's the finality of the divorce which is even worse…
— Leif Erikson (@Tremorden)February 3, 2014
@Tremorden Leif,I gotta give you props for your response to Jenny's recent LJBF. Well done, have a read: http://t.co/CcJiPPdxmA
— Rollo Tomassi (@RationalMale) February 27, 2014
In 2016, more was revealed about Jenny Erikson.
In 2018, Jenny Erikson wrote about a man that's had many executive positions including his years as Vice-President of one of the most exciting startups that's advised by the best early stage investment firm. Then there's this:
The relationship is on display in 2018:
My significant other, asking for a favor this morning, adds, "Because you love me…" Wrong. I only love you at 5:30 am if you're bringing me coffee or changing a diaper. 😘
— Jenny Erikson (@JennyErikson) June 7, 2018
You make it sound like it was something kinky. I wanted you to watch a movie trailer with Bradley Cooper and Lady Gaga reprising the roles of Kris Kristofferson and Barbara Streisand. Listen to them sing out loud at 5:30 AM! 🎶 🎤 😂
— Justin Hart (@justin_hart) June 7, 2018
— Jenny Erikson (@JennyErikson) June 7, 2018


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Italeri 1451 1:72 B-52G Frühe Ausf. m. Hound-Dog
The B-52 Stratofortress is the most famous long-range jet-powered strategic bomber in the aviation history. Produced
by the American company Boeing since 1955 it has been, for a long time, a symbol of the Cold War. It has been, for
several years, the backbone of the United States Air Force Strategic Air Command. The B-52 has been produced in a
significant number of versions that has gradually evolved the successful project to better answer to the changing in
operational needs. The "G" version is the most produced B-52 variant, and it has been delivered to the S.A.C. wings
from the early 60s. It could be armed with the North American AGM-28 Hound Dog stand-off air-to-surface nuclear
missile that was part of the US nuclear arsenal until the mid-1970s. It was developed in the middle of the "Cold War"
to carry out nuclear attacks on high priority land targets such as air and missile bases.
Italeri nummer: 1451
EAN nummer: 8001283014519
incl. 19% MwSt
incl. 19% MwSt
incl. 19% MwSt


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ANSA is a private club with 501(c)3 status, formed to support Nordic skiing and related winer recreational activities in the Auburn area. You can find us on Facebook: ANSA and Bill Koch.
Our vision: High quality Nordic Skiing for everyone in the LA community.
Our mission: The Auburn Nordic Ski Association (ANSA) promotes learning and enjoyment of Nordic skiing and related outdoor winter recreation by maintaining expertly groomed trails that support fitness, family and community enjoyment, skiing education, and coaching at all levels from toddlers to adult.
Our activities: We maintain both groomed Nordic ski trails and snow shoe trails. We support the Auburn Middle School and Edward Little High School Nordic teams and the Bill Koch Youth Ski League. We host some fun local events and occasional races. And, of course, we ski every chance we get.
Lessons and rentals:
- ANSA doesn't offer lessons, but Nordic skiing is something that one can pick up fairly easily.
- The closest rentals are at Carters in Oxford, or Pineland Farms in New Gloucester. Pineland offers group and private lessons. Akers Ski in Andover, Boulder Nordic in Portland, LLBean in Freeport, and Northern Lights in Farmington sell equipment. Snowshoeing doesn't require lessons - you just walk! We have trails that go from our parking area through the woods, although in truth the beauty of snowshoes is that you can go anywhere.
Detailed membership information is available here.
PLEASE encourage your skiing friends to join ANSA, and invite your not-yet-skier friends to ski with you. Help them learn how much fun Nordic skiing can be.
How to join:
Prices and the club application form are here.
Where we are:
The main access to our trail system is through Lost Valley in Auburn. If you are not a member of ANSA, please stop at the lodge and purchase a day ticket. (If you are a member of ANSA, please feel free to use our private Perkins Ridge entrance.)
Ski trail maps can be found here. Snowshoe trail maps can be found here.
You can view them online or download a pdf.
Governance, participation and feedback:
We are an all volunteer organization managed by a working committee of: Bruce Condit (president), Rick Speer (treasurer), Amos Woodward (chief groomer), Norm Duphily, Steve Bennett (equipment manager), Ben Lounsbury (team education liaison), Peter Elias (media), Faith Barker, Holly Ewing, Susan McHugh, Marsha Bennett.
If you would like to help, please let us know. The ski season is all too short, but the opportunities to contribute are many. In the Fall, we do some trail maintenance. There is grooming and grooming equipment maintenance. Signage. The Bill Koch program. Local events. Publicity. Photographs and stories for this site. And plenty of other things only YOU can think of.
Contact us with feedback and suggestions.
Thanks, and happy skiing.


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Lustre Metallic Dark Silver
Shipping and taxes calculated at checkout.
Our "Edible Silk" colours are a unique and exquisite range of food grade pigments developed to give your products the eye catching and distinctive look they deserve.
They consist only of edible, widely approved food colourants and/or iron dioxide.
The shine and colour effects are completely different to those using common absorption or metallic pigments normally used in the food industry.
- Nut free
- GM free
- Gluten free
- Suitable for vegetarians
- 100% Edible


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This article is more than 1 year old
Microsoft plays Show me, Tellme
Buys speech recognition firms
Microsoft is amping up its voice recognition capability, with the acquisition of Tellme Networks, a 320-man firm based in Mountain View, Calif. Terms are undisclosed, but Microsoft is said to be paying more than $800m, making Tellme its biggest buy since 2002, Bloomberg reports.
Tellme supplies voice-activated services for phone, including directory assistance and mobile search. And Microsoft, which says it has only scratched the surface of what is possible in speech technologies, likes 'em a lot.
Here's a quote from Steve Ballmer, Microsoft CEO: "Speech is universal, simple and holds incredible promise as a key interface for computing. Tellme brings to Microsoft the talent, technology and proven experience in speech that will enable us to deliver a new wave of products and revolutionize human-computer interaction."
We're scared already.
With Tellme's help, Microsoft wants to build voice user-interfaces in existing Microsoft products. Also it wants to speechify Microsoft Live Search for mobile phones and integrate with TellMe's mobile search services. The company is also keen to develop voice-enabled customer service products already.
TellMe's staff will carry on hanging out in Mountain View. Which is nice. ®


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Learn what is important to tell the caterer when you call them. The more information you can give them, the more detailed proposal the caterer will be able to provide.read more
Learn what is important to ask the caterer when you call them. You want to ensure they are the right company for the job, and can take care of all your event needs.read more
There are many catering myths out there. For example "food is 99% of your catering bill" or "caterers always serve rubber chicken." Let's take a closer look at these myths.read more


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Archive for month: January, 2015
AAO Wafer Holder for Electrodeposition/in Nanofabrication Toolbox, Products, Recent News/by InRedox
The AAO Wafer Holders for templated electrodeposition are now available for 25 mm sized AAO wafers with contacts. Using wafers of larger size increases deposition uniformity and provides the ability to test your process for scale-up.
Nanoporous AAO Films on Optical Surfaces/in AAO Nanotemplates, Products, Recent News/by InRedox
InRedox introduced a new capability – AAO films or nanotemplates integrated onto the surface of optical components, i.e. optical windows, mirrors, prisms, lenses, glass slides and other types of substrates. This exciting capability provide new sets of opportunities for designing new experiments in photonics, metamaterials, bioimaging etc.
To learn more, visit the AAO nanotemplates product group on our website and contact us with your requirements.
1840 Skyway Drive, Unit F
Longmont, CO 80504 USA


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Elizabeth Parker
|Production Credits
Incidental Music: Timelash(as Liz Parker)
|2 credits in
1 entry
Elizabeth Parker
Elizabeth Parker is a British film and television composer who worked at the BBC Radiophonic Workshop for many years.
She is best known for providing special sound for the BBC science fiction series Blake's 7 taking over from Richard Yeoman-Clark from Season 2 onwards. She also provided the music for the episode "Gambit".
She also provided the incidental score for the 1985 Doctor Who story Timelash under the name Liz Parker. Parts of this score are featured on the Doctor Who: 30 Years at the BBC Radiophonic Workshop compilation. An LP of her score for the television series The Living Planet was released in 1984.
Elizabeth Parker was the last composer to leave the Radiophonic Workshop before its closure in 1998.
Outside of this she has also contributed music for the series Fred Dibnah's Building of Britain, The Human Body, Animal Games, Weird Nature, and many other television series.
Biography from the Wikipedia article, licensed under CC-BY-SA


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Design, manage, sell & grow with Wix's powerful end-to-end platform. Get your free domain & start building in minutes.
Make a difference and share your love for the environment on a .eco domain extension!
.eco is a versatile new domain extension that allows individuals, businesses, groups and more to show their interest and dedication to our natural environment. The .eco domain can be used by those involved in scientific research, environmental protection, fundraising, publishing, information sharing, and many other functions related to environmental causes. Be part of the eco movement with a .eco domain name.
.eco is a "Regulated Domain" which is subject to additional requirements mandated by ICANN.
Legal Compliance: Registrants must comply with all applicable laws, including laws relating to privacy, data collection, consumer protection (including in relation to misleading and deceptive conduct) and applicable consumer laws in respect of fair lending, debt collection, organic farming (if applicable), disclosure of data and financial regulations;
Health and Financial Information: Registrants must acknowledge and agree that those who collect and maintain sensitive health and financial data must implement reasonable and appropriate security measures commensurate with the offering of those services, as defined by applicable law;


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Fantastic snow removal after 15cm of snow, ice pellets, freezing rain and rain. And with them being so busy, still did my driveway the same day, as they said they would. They salted everything too. Highly recommended and I absolutely will use them again.
- Approximate cost of services:
- $90.00
Was this review helpful?
- Company Response
Thank you so much for being patient with us! We want to make our clients very happy!


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Innovative Office Solutions
Office Supplies, Equipment & Furniture
Driving Directions:
From Division Street (Hwy 23) take Cooper Ave S to Roosevelt Rd. Drive south on Roosevelt Rd 2 miles. Take a right onto Cheryl Drive and next left onto Sunridge Drive. Innovative is on the left past Blue Line South and Graybar.
About Us
Powered by a vision of "Inspire People to Love What They Do, And Who They Do it With", Innovative's culture is built upon the idea that Relationships Matter and through highly customized partnerships we can help our customers find success. Guided b


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My Training Journal 2016
I'm not big on writing things down, it's all kept in my head. I think that's why I've enjoyed the whole process of creating a blog; it's my online journal for my thoughts, ideas, stuff I've researched and for recalling my own fitness journey.
So I've decided to add my own training journal to my blog. Why? Firstly, the weird numbers I write on my calendar baffle my kids. Ok they are my PB's and once upon a time meant something to me but I hardly ever flick through my calendar to recall my running times so I suppose they are rather meaningless. It's also not the right place to perhaps note my gym training sessions. Besides the calendar gets cluttered up with everything else associated with running the Taylor Family; Guitar lessons, Rugby fixtures, play dates, dentist appointments, you get my drift? Secondly, putting on my gym training sessions will give me the chance to reflect on what I have done and maybe provide a focus to what I need to do next. Finally, it might give me a bit of motivation when the sofa and Netflix are calling!
I've no intention of writing everything that I do, that would be the blog equivalent of watching paint dry, so I'll add what I consider the highlights. Let's just see how it goes?
October 2016
Friday 5th October
Last month I re-evaluated how often I train and decided to switch to Full Body Workouts, here is the second of my Full Body Workouts. Seems to be working well. I get a full body workout in 40 minutes which is fitting in with everything else that's going on in my life at the moment.
September 2016
Sunday 11th September
Put together a HIIT Workout, it is easy to put your own together once to know what exercises target what parts of your body.
Saturday 17th September
Trying to run a 5km twice a week. I'm a fair weather runner so if it's chucking it down I'll do a HIIT workout instead.
Sunday 25th September
It's been a hectic month so I've had to re-evaluate how I workout and in particular the amount of time I spend training. So I've gone back to performing a Full Body Workout each gym visit instead of concentrating only on one area. So here's my first of 2 Full Body Workouts.
August 2016
Thursday 4th August
My Holidays are less than a fortnight away, Carried on with my gym programme and incorporated some HIIT workouts into my weekly routine.
Saturday 27th August
Back from my holiday in Cornwall. Relaxed and chilled despite the 13 hour drive home! No gym visits or 5km runs for 2 weeks. It was all long walks on the beach, chilled out evenings, lazy mornings and the most amazing surfing conditions (well for my kids anyway). So first time back in the gym, decided to take it easy, decided on an old favourite of mine in the form of a conditioning session.
July 2016
Mid Summer. Weather not to bad so have been getting a few runs in.
First 2 weeks have continued with same Gym Programme with 3 separate workouts (Legs, Chest & back, Shoulders) in the week.
I've been continuing with the HIIT; it's quick and get the heart pumping. Do I feel better for it? Yes I think so. After a hectic June and bad habits creeping in, I'm trying to eat healthier and am making a conscious effort not to slip into eating only cereal when I am stuck for time.
Saturday 15th July
1 week until I finish work for the Summer and 4 weeks until I go on holiday! New Gym programme; slightly different from my last workout routine. Back to Rack Pulls and Back Squats; heavier weight, low reps and short rest intervals.
Wednesday 27th July
A mad couple of weeks has seen the walls very nearly fall off my traning schedule but I think I'm back on track. Conditioining session today has helped me focus and motivate me to pursh harder. Rack Pulls, Sled Drags, Farmers Walks. Tough mentally and physically but I enjoy the post training buzz and come away with a real sense of achievement.
June 2016
Wednesday 1st June
I fly to New York tomorrow for 4 days so in preparation worked extra hard at the Gym this morning. Ok it's a guilt thing but feeling of achievement after a leg blast! Rest of the day spent packing and re-packing. I'm beyond excitement! I managed to sort out new Playlists for June so I've got new tunes to listen to when I get back to the Gym; Workout Playlist June 2016 and Running Playlist June 2016.
Wednesday 8th June
NYC was amazing. Frantic, mad, exhilarating! We certainly made the most of the trip but definitely only scratched the surface of this fabulous city. OK so hardly slept, over-indulged when it came to food but had a thoroughly fab time. Using the tracker on my phone we walked roughly 60km in the time we were there so it wasn't all bad!
So went for a 5km this morning. Hard is an understatement but it's in the bag. It is so easy to get out of a routine but completing that first run hopefully has got me back into fitness mode. My trip to NYC helped increase my motivation when it came to the Gym and for me I think that's important. With fitness goals I need to reward myself along the way but also have an end goal; my end goal was to wear a pair of shorts with confidence whilst stomping the streets of NYC and that's what I did! I've just booked my annual holiday in Cornwall for the end of August so that's my motivation to train harder, keep up the running that way and have something to look forward to!
Friday 24th June
The past week has been extremely busy at work; probably the biggest week for me and the team I work with. 3 day multi sports event for children in Newcastle. Love this week but it does take it's toll on everything else including my fitness and diet. Small sacrifice to pay for all the medals won, happy smiling faces and proud parents! Still I have managed to get to the gym and did a 5 km on Tuesday despite falling over, smashing a phone and using my elbow and knee as a brake! Doh!
Friday 30th June
Workwise it's been slightly less hectic. No early morning starts so I've been back to the Gym instead. Instead of running I've been doing some low impact HIIT Workouts courtesy of the Body Coach. Huge fan of Joe Wicks, have been for a log time. If you are new to the Joe Wicks phenomenon have a go at his Low Impact HIIT Workout. I've done this workout 3 times this week, max 20 minutes and it's definitely got my heart thumping!
May 2016
My favourite month of the year. Countdown to Summer begins for me. Late spring, weather improving, 2 Bank Holidays to enjoy and half-term for me and the kids! What's not to like?
It's a month till I go to New York with 3 fabulous, gorgeous ladies. It's going to be hot in New York so the shorts and summer clothes are going to come out. Best up my fitness game and start eating more healthy, especially after the chocolate re-lapse I seem to still be suffering from since Easter!
New month means new playlists. I get bored of listening to the same old music so here is my Workout Playlist May 2016 and Running Playlist May 2016 in case you are after some inspiration.
Tuesday 2nd May
Gave my fitness a jolt by doing a Conditioning Workout; really enjoyed this session. Heart pounding, felt like it did some good.


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Review of Rocca Calascio, 2015
Our second trip in three years to Rocca Calascio was another mix of great company, the cucina divina of Abruzzo, sublime vistas and the gracious hospitality of all at the Rifugio della Rocca.
My sincere thanks to: Ludovica, Roberto, Daniela, Spass, Victoria, Kristin, James, Ruby, Mo and Oliver!
Pictures and video below.


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by Pat Thomas
(Ponte Vedra FL)
I replaced Jazz's hard leather rolled dog collar with one I made from the belt of an organic cotton robe. I cut off about 15 inches of the belt and loosely knotted it around Jazz's neck. Now Jazz doesn't wake up in the middle of the night scratching at her neck!
Join in and write your own page! It's easy to do. How? Simply click here to return to Coton de Tulear Pictures.
Copyright© 2008- All Rights Reserved


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Dennis Potter CourtDennis Potter Court, Hadley Close, BIRMINGHAM , B47 6LT
Dennis Potter Court is a warm and welcoming scheme in Wythall, 10 miles south of the centre of Birmingham. The area enjoys a semi-rural setting and the atmosphere of a village community yet is conveniently located a short distance from a wide range of local facilities.
Buses to Birmingham and Redditch run hourly from a stop just a few minutes' walk from the court. Solihull town centre is less than half an hour away by car, bus or train. The nearest train station is just a mile away. The court is served by a dial-a-ride service and a number of reliable taxi firms.
Dennis Potter Court has a range of on-site facilities for residents, including a large communal lounge, kitchen, laundry, en suite guest room and lift.
The court is surrounded by extensive and well-maintained gardens, with attractive flower borders and lawns. Residents are welcome to join in with the gardening if they choose. During the summer months some social events take place in the grounds.
- Lounge
- Laundry room
- Guest room
- Garden
Dennis Potter Court is a friendly scheme where residents enjoy a range of social activities including regular bingo sessions, darts, coffee mornings and fundraising events. The residents and staff have strong links with the local community and a local church group. Residents often arrange social outings and the court enjoys social evenings where entertainment is provided.
Nearby amenities include supermarkets, a doctors surgery, dentists, library, banks, bakery, post office and an opticians. A pet shop, hairdresser, butcher, chemist, florist, churches and takeaways are also just a short walk away.
|Service Charge*
|Support Charge*
|Utility Charge*
|*Costs are indicative for a range of properties. For detailed costs on each property please contact the Court Manager.
Register your interest
To talk to our team, please don't hesitate to get in touch


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Evaluation Tool for Comparing Vaccine Protection Options - emergency planning for storms, power outages, etc. (PDF)
Table: Solutions for the Protection of Vaccines During Power Outages (PDF)
Vaccine Refrigerator Cost Comparison Worksheet (PDF)
After using a refrigerator/small freezer combo. for vaccine storage, and dealing with the out of range temperatures too many times, I decided to purchase the TempArmour Vaccine Refrigerator. It maintained the temperature perfectly, and never went out of range for all of the studies we needed it for.
I highly recommend this vaccine refrigerator.


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Handy Pocket Guide - Sashiko 20446
This mini forty-eight-page book is packed with mega information on all the key sashiko basics! Best-selling author Sylvia Pippen shares everything from a bit of history and applications for sashiko to the necessary supplies, how to mark the designs, and stitching techniques. Even learn how to create your own sashiko design from your favorite inspirational photo! Or use one of the twenty-seven included designs. Plus, at such a great price, you can afford to buy one for your sewing group, sister, mom, friend, or anyone else you know who loves to sew as much as you do!
- Sashiko is easy to do on the go and this guide is perfect to go with you
- Twenty-seven designs in a handy pocket size
- Tips and tricks to make sashiko embroidery more successful, including how to prepare the thread, how to avoid pulling, successful stitching, and even ironing


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- About
- Our Clients
- Focus Areas
- News
- Insights
- Events
- Contact
From Global Trade Review (GTR) | By Shannon Manders
Barclays' global head of trade and working capital Baihas Baghdadi has left the bank. Sources tell GTR that he will be replaced by Deutsche Bank's James Binns, who currently holds the position of global head of cross product solutions, cash management. It is understood that he will join Barclays in September.
The reason behind Baghdadi's departure, and his next move, remain unknown to GTR. He had been with Barclays for 10 years and was appointed trade head in 2015.
Binns has been with Deutsche Bank since 2014 and previously worked at HSBC in a variety of trade roles across a number of locations.
The post Barclays gets new trade head after Baghdadi departure appeared first on Global Trade Review (GTR).


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|Original language
|Social Policy Research Centre, The University of NSW
|Commissioning body
|Aboriginal Affairs NSW
|Number of pages
|Publication status
|Published - Jun 2018
|Externally published
Bibliographical noteUNSWorks is the UNSW Open Access institutional repository which enables UNSW researchers to make their research outputs freely available and accessible.
Unless otherwise stated, materials deposited in UNSWorks are protected by the Copyright Act 1968 and are licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives Licence (CC BY-NC-ND). This licence permits the use of the material subject to the following conditions:
attribution - give appropriate credit and provide a link to the licence
non-commercial - the material may not be used for commercial purposes
no derivatives - the material cannot be distributed if it has been remixed, transformed, or built upon
- Indigenous Cultures
- Language Groups
- Tharawal
- Culture Nests


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Chicago-based Skidmore, Owings & Merrill's (SOM) plans for the redevelopment of the East Riverfront in Detroit, Michigan have now been unveiled.
The Detroit RiverFront Conservancy, Detroit Economic Growth Corporation, and City of Detroit Planning and Development Department will work together to deliver SOM's plan to revitalize the former blighted industrial area.
The framework plan involves improving community access to the riverfront, the design of a new riverfront parkland, and the conversion of a historic riverfront structure into a mixed-use development.
The Detroit RiverFront Conservancy, Inc. was formed as a 501 (c) (3) with the mission of developing access on the Detroit International Riverfront. The entire vision is 5 ½ miles of Riverfront property, from the Ambassador Bridge to Gabriel Richard Park, just east of the Belle Isle Bridge, and will include the construction of a continuous RiverWalk along with plazas, pavilions and green spaces. The Conservancy is responsible for the improvement, operations, maintenance and programming of the Detroit International Riverfront in perpetuity.
Detroit Economic Growth Corporation is a non-profit organization that works closely with the City of Detroit and other partners to support existing businesses and to bring new companies and investments to the city. The professionals who work for DEGC act as staff for a number of public authorities and whose board members are appointed by the Mayor and approved by Detroit City Council. Each of those entities have distinct responsibilities and powers, but they are very closely related. By using a common staff – DEGC – the work of these public authorities is well coordinated and avoids duplication. DEGC also works directly for the City of Detroit under contract and manages economic development efforts funded by private and foundation contributions, grants and contracts.
SOM is one of the largest and most influential architecture, interior design, engineering, and urban planning firms in the world. Founded in 1936, they have completed more than 10,000 projects in over 50 countries.
All images courtesy of SOM.
See full Arch Daily article by Niall Patrick Walsh.
See Detroit RiverFront Conservancy website.


text: In the weeks before Christmas day in December, the Lord Mayor of London makes a speech in front of invited guests and VIPs, hosting his annual party in the Great Hall at his official town hall - the Guildhall - in the historic financial district of the City of London. Inviting Greater London's borough Mayors, they can each invite worthy children for an afternoon's fancy dress party. The Guildhall has been used as a town hall for several hundred years, and is still the ceremonial centre of the City of London. The term Guildhall refers both to the whole building and to its main room, which is a medieval style great hall similar to those at many Oxbridge colleges. The great hall is believed to be on the site of an earlier Guildhall, and has large mediaeval crypts underneath. During the Roman period it was the site of an amphitheatre, the largest in Britannia.Add to Cart Add to Lightbox Download


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Cheating partner shifts blame for collapse of relationship
DEAR ABBY: My partner of 11 years has decided he is no longer in love with me. He says it's because he thinks I cheated on him. I have told him repeatedly that it didn't happen, which is the truth.
My partner of 11 years has decided he is no longer in love with me. He says it's because he thinks I cheated on him. I have told him repeatedly that it didn't happen, which is the truth.
Long story short, he says he wants us to start over as friends and see where things go because he doesn't want to be in a relationship with anyone right now. However, he's sleeping with a 22-year-old here in the home we share. I love him so much that it hurts. When I tell him every day that I love him, he tells me he knows. Our relationship hasn't been a bed of roses, but we did have good times when we were able to do things together. Should I hold out for him, or tell him the "friends" thing is not going to work and cut ties altogether?
- Confused and lost guy
DEAR GUY: I don't blame you for feeling confused and lost, considering the mixed messages you have been getting from your partner. What you are experiencing now is, of course, painful. He is making excuses for wanting to trade you in for a newer model. This is why he is accusing you of having done something that he is doing under your nose.
The only true confession he has uttered is that he doesn't want to be in a relationship. That is your cue to head for the door, unless, of course, the roof over your head belongs to you. If your home is rented or jointly owned, other arrangements will have to be made. But for the sake of your sanity, do not live with him under these conditions, or he will make you old before your time.
Niece needs guidance for appropriate dress
DEAR ABBY: My family includes a niece and her husband with three kids ranging in age from 8 months to 7 years old. The middle child, a 5-year-old girl, is allowed to choose her own outfits for family gatherings and school, with appalling results. Her hair, which is long and tangled, goes unbrushed. Her ill-fitting clothes are worn and inappropriate for the weather and school. When I discussed it with her parents, their answer fell flat.
Because she's learning to dress herself without parental guidance, she's not learning what's appropriate. When they came for Thanksgiving dinner the child showed up in summer clothes - sleeveless top, thin cotton skirt, etc. By the end of the evening, she appeared ill.
I'm surprised neglect charges haven't been filed against the parents. Any suggestions to get across to them that their parenting style is lacking?
- Worried relative
DEAR WORRIED: Your dilemma isn't how to get across to the parents that they need to teach their child better fashion choices. If that little girl is going around with tangled hair and summer clothes in cold weather, it may be that her parents are unable or unwilling to give her the basics. I, too, am surprised that the school hasn't contacted Child Protective Services to do a welfare check. Since they haven't, you should talk to these parents again and voice your concerns.


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Photo via: @fashion_jackson
Getting dressed for fall and winter is a breeze when you have a go-to outfit ready. This street style look is giving us all the inspiration we need to get dressed on any given day. Combine black skinny jeans, edgy combat boots, a cozy grey scarf, a black leather jacket, and a classic handbag for an easy, chic look that you'll want to wear every day.


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MILAN (Reuters) - Italy's Agnelli and France's Peugeot, the largest shareholders in Stellantis, have signed a consultation agreement, holding companies representing the two families said on Wednesday, on the eve of the carmakers' first annual general meeting.
Exor and Peugeot 1810 said in a joint statement they had entered an understanding "aimed at strengthening the relations between the Agnelli and Peugeot families and to provide support for Stellantis in its long-term success".
The accord will allow the two companies to exchange views, while leaving them free to vote as they choose and not carrying any obligation to coordinate their actions as Stellantis shareholders, they said.
With a 14.4% stake, Exor is the single largest shareholder in Stellantis, the world's fourth largest carmaker, which was formed in January through the merger of Italian-American Fiat Chrysler and France's PSA. Peugeot 1810 has a 7.2% stake.
(Reporting by Giulio Piovaccari; editing by Barbara Lewis)


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I won't pretend that I'm the master of worldbuilding, but I will say that I am proud of the world that I built for my novel series A Thousand Watchful Eyes. For my current novel, The Witch's Uprising, I've made several revisions to the world of Brylennia, ensuring that my fantasy world is both beautiful and believable. Just the other day, I found some of my original notes and maps. I'm surprised at how much has changed since day one!
Here are five articles that I've found useful while creating my fantasy world:
7 Deadly Sins of Worldbuilding – Gizmodo
The Ultimate Guide to Worldbuilding – Writer's Edit
10 Rules for Making Better Fantasy Maps – Gizmodo
Fantasy Worldbuilding Questions – Physical and Historical Features
Questions to Ask When You Create A Fictional Culture – Alyssa Hollingsworth


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It's been awhile since the New England Revolution had success on the offensive end of the pitch. Going into the match against the Philadelphia Union, the Revs were sitting in last place in the I95 Corridor Cup and second to last place in the Eastern Conference. Twitter was already exploding pregame with negativity (as Twitter is prone to do).
However, there is nothing like a win to reengage fan passion. New England played their most complete game of the season, and Twitter went nuts with...joy? Whether it is Rowe's early miss, the breaking of the goal-less streak, the excitement of three points, or the appearance of Sainey Nyassi on the 18, Twitter was prepared to celebrate like we won the MLS Cup and simultaneously smash us like we "won" the Wooden Spoon.


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with adjustable square wave pulser
- Adjustable spike & Square wave pulser up to 500V
- High resolution display screen with 640×480 pixels
- VGA video output
- Adjustable damping
- Operation frequency up to 20 MHz
- High dustproof & waterproof: IP65 (IP67 as option)
- Optional functions: Network Projection / DAC_JP function / Auto Freeze / Spectrum Display / TCG
Superior Features
- Operating frequency range: 0.5 ~ 20 MHz, highlighting advantages of high sensitivity and broadband.
- Adjustable pulse width square wave transmission is up to 500 V.
- 20 ~ 2000 Hz PRF with 10 steps adjustable: avoid reverberation signals during flaw detection.
- The convenient and useful probe spectrum analysis function enables the users to know the probe waveform, spectrum and center frequency, resulting in more precise flaw detection evaluation.
- Measure crack height by edge peak echo method.
- Max. sampling rate 240 MHz; Measurement resolution 0.1 mm.
- RF (Radio Frequency) echo display: good to thin-wall material measurement, academic research or qualitative analysis.
- The DAC curve works with echo compare function, making echo quantification of different distances and amplitudes more convenient.
- The AGC (auto gain control) function, together with peak echo and image freeze function, help quickly identify the flaw highest echo, enabling efficient flaw detection.
- Advanced thickness measurement function available.
- Featured with AWS D1.1/D1.5 and API 5UE evaluation standards.
- The gate magnifier function magnifies the echo area within the gate to the whole screen display.
- Up to 500 sets of curve and waveform can be saved for various workpieces and flaw detection standards.
EN-12668-1 and ASTM E317-1 compliant
Application Examples
Ethernet Communication
With network communication, the CTS-9009PLUS can be connected to a PC directly via 100Mbps Ethernet, so as to achieve real-time display and remote control.
- Detection echoes, curves or parameters may be losslessly stored to a PC via 100 Mbps Ethernet, facilitating report editing and data management.
- Screenshot and detailed info can be transferred into Microsoft Word for customized reporting.
Typical Applications
The CTS-9009PLUS is designed to increase productivity in various inspection situations.
It is suitable for inspection flaw position and size, which can be widely used for various detection demands, such as pipes and tubes,welding seams, pressure vessels and airplane parts.
Application examples are as follows:
Weld Inspection
- Weld groove profile function
- Peak memory function
- AVG / DGS curve
- Advanced DAC curve
Forgings and Casting Inspection
- Adjustable square wave pulser: Up to 500 V pulse voltage
- Manual PRF adjustable:20~2000Hz with 10 steps adjustable
- Peak memory function
- AVG/DGS curve
Thin PLates Inspection
- High operating frequency: 0.5 ~ 20 MHz
- Manual PRF adjustable: 20 ~ 2000 Hz with 10 steps adjustable
- Good near field resolution
- Peak memory function
- AVG / DGS curve
Rail Inspection
- High PRF: Up to 2000 Hz
- Lightweight:The whole unit weight (battery included) is approx. 1.25 kg.
- Peak memory function
- Advanced DAC curve
- AVG / DGS curve
(NDTech Indonesia)
PIC: Ir. Pranata Harianto
Mobile: +62 811 987 291
email: [email protected]


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Semantic Construction Grammar - a meaning-centric approach to NL Understanding
author: Michael Witbrock, IBM Thomas J. Watson Research Center
published: Feb. 15, 2012, recorded: January 2012, views: 5445
published: Feb. 15, 2012, recorded: January 2012, views: 5445
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by Joeriz Josef M. Chu
(Baybay City, Leyte, Philippines)
The truth is you don't know what is going to happen tomorrow. Life is a crazy ride, and nothing is guaranteed.
Life is like a piece of art,
It needs a genuine heart.
Choose your paint and your brush,
Take your time, avoid the rush.
Before you paint choose your theme,
Don't be afraid to follow your dream.
It's alright, to make a mistake,
Your painting is real, it's not fake.
Watch at your painting, don't be crying,
Try again, keep on trying.
Your painting will never be fully complete,
Enjoy the steps, make sure it's sweet
Join in and write your own page! It's easy to do. How? Simply click here to return to Inspirational Poems.


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Sessions 'will recuse himself from Russia investigation if necessary' - report
Attorney General Jeff Sessions has denied discussing "any political campaign" with Russian representatives.
The comments come after calls for him to resign over allegations he lied under oath during his confirmation hearing about his contact with Russians. Speaking to NBC, Sessions said "I have not met with any Russians at any time to discuss any political campaign and those remarks are unbelievable to me and are false."
READ MORE: 'Sessions lied': Top Democrat calls for US Attorney General to resign over alleged Russia ties
Sessions added that he would recuse himself from the 'Russia investigation' if it came to that, NBC reported.
WATCH: AG Sessions says, "I have not met with any Russians at any time to discuss any political campaign." https://t.co/OcGWQql7P3— NBC News (@NBCNews) March 2, 2017
On Wednesday a congressional committee agreed to an investigation into Russia's alleged "targeting the 2016 U.S. election."
READ MORE: US House intel panel approves scope of probe into 'Russian activities in US elections'
According to a statement from the US House of Representatives Permanent Select Committee on Intelligence, one of the questions being investigated is "Did the Russian active measures include links between Russia and individuals associated with political campaigns or any other U.S. Persons?"
Off-camera on Thursday, Sessions reportedly told journalists that "whenever it's appropriate I will recuse myself, there's no doubt about that."
MORE: Sessions says, "Whenever it's appropriate I will recuse myself, there's no doubt about that."— NBC News (@NBCNews) March 2, 2017
The attorney general has been accused by House Minority Leader Nancy Pelosi of lying under oath when, during his confirmation hearing, he told Senator Al Franken that he did not have communications with Russian officials during Donald Trump's election campaign.
READ MORE: Russian Embassy brushes aside Sessions contact allegation
Sources, allegedly from the Justice Department, told the Washington Post that, despite his answer at the confirmation hearing, Sessions had in fact spoken to Russian Ambassador to the US Sergey Kislyak twice last year.
Sessions' latest comments echo an earlier response by DoJ spokeswoman Sarah Isgur Flores, who said: "He was asked during the hearing about communications between Russia and the Trump campaign — not about meetings he took as a senator and a member of the Armed Services Committee."
Pelosi has been joined by a number of Democrats, including Senator Elizabeth Warren, in calling for Sessions to reign and for a bipartisan investigation into Donald Trump's alleged ties to Russia.
We are far past recusal. Jeff #Sessions lied under oath. Anything less than resignation or removal from office is unacceptable.— Nancy Pelosi (@NancyPelosi) March 2, 2017
#Sessions 'faces tough questions': Social media reacts to alleged Russian ties https://t.co/WJXronWdPbpic.twitter.com/7ozG8dpE0l— RT America (@RT_America) March 2, 2017


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Start Your Day Off Right: Why A Morning Run Is Better Than Coffee
I used to be a coffee junkie. One cup in the morning to get me started. One cup after lunch so I don't crash.
And another cup in the evening just for kicks. Those were some of the most stressful years of my life.
Coffee is a great quick-fix, but quick-fixes are never really fixes; they're bandages that always manage to come undone.
Luckily, a friend put me on to something much healthier and -- to be completely honest -- much more effective: I started running.
You start off slow and short but make your way up to quick and long. Although I may have a cup of coffee here and there, I don't drink anywhere near as much as I used to and never first thing in the morning.
If you're doing anything first thing in the morning, it needs to be cardio. If you're not having sex, then I recommend running.
1. It gets your head straight, and your mind focused.
Coffee is great for getting you motivated to start your day, but it isn't very good at giving you the peace of mind necessary to start your day right.
Motivation is great, but if you don't have the mind necessary to make proper, well-thought-out decisions, then it's sort of useless.
Running takes all those running thoughts in your mind and forces you to refocus them onto your two feet hitting the pavement (or treadmill).
It forces you to quiet your mind because not doing so would cause you to trip and face plant.
After your run, all those chemicals produced and all the energy released leaves you feeling calm, at peace and ready to take on the world. Or your nine-to-five.
2. It's never easy, but starting off with the most difficult part of your day makes for smooth sailing.
Drinking a cup of coffee first thing in the morning is like taking a break before you even get started; that's why they call it a "coffee break." Starting things off easy makes scaling up difficult.
If, on the other hand, you start things off with a four-to-six-mile run at a respectable pace, sweating profusely, pushing yourself a little further with each quarter mile, the rest of your day won't seem so difficult.
After running out of breath and sweating a kiddy-pool's worth, everything else seems like a piece of cake. You can either have a cup of coffee and climb a mountain or go for a run and cruise along that mountainside.
3. It gets your heart pumping like coffee, without the crash.
Coffee is a bit deceiving. After a cup, you feel like a champ, king or queen of your kingdom.
But after a couple of hours, things start to go south. That buzz you were riding becomes more of a murmur. After another hour, you find yourself in need of another boost.
You raised the energy bar so high first thing in the morning that you'll spend the rest of the day trying to bring it back to that state. Not so good for you, but great for the coffee companies.
Going for a nice run doesn't put you on edge. Instead, it makes you feel lighter, strong, quicker, sharper.
It clears up that fuzz you see and feel, outlining everything in your reality -- both your visual representation of the world around you and your thoughts.
The best part is there is no crash. You just keep going steady.
4. No amount of coffee in the world will have you feeling as good tomorrow morning as running this morning will.
You would be much better off planning for tomorrow than trying to fix today.
Yes, coffee gives you the illusion of energy, of sharp thought and rapid reaction. But it's pseudo-energy. It doesn't stay with you because it isn't a part of you.
Running harnesses the energy inside of you and makes it easier for it to surface. We are all made of energy -- we just can't always call upon it when we need it.
We wake up feeling sluggish, but instead of loosening up our body and minds, we drink a cup or two of coffee.
It feels like energy, but you won't feel any better tomorrow morning. Instead, you're going to need to repeat the process just to feel normal.
If, instead, you decided to run today in the morning, you may feel a little bit drained once the sun goes down, but getting out of bed tomorrow will be easier.
The longer you keep the routine, the easier it will become -- until getting out of bed and tackling all the matters at hand will feel effortless.
What sounds better: spending $5 a day (if not more) on coffee just to feel like you NEED more of it or running for free and feeling better each and every day? The choice is yours.
For More Of His Thoughts And Ramblings, Follow Paul Hudson On Twitter, Facebook, And Instagram.


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Microtubule assembly and disassembly is regulated by their interactions with associated proteins which are specific to cell types and locations. It is important this regulation takes place as microtubules play an important role in cytoskeleton stability, cell shape, and also for the transport of organelles, vesicles and chromosome movement when the cells needs to respond to external/internal stimuli. Two examples of proteins that regulate microtubules are tau and stathmin.
Tau is a MAP (microtubule associated protein). It is coded by the tau gene on chromosome 17. It is found in neuronal cell bodies and specifically regulates microtubule growth out of the cell body and into the axons. It therefore plays an important role in neuritis growth and also forms the skeleton for vesicle/organelle transport in neurons which is important in signal transduction. It is also believed to stabilize the axonal core by increasing microtubule interactions with other intracellular components e.g. actin filaments. Tau comes in different forms which are found in different locations such as spinal cord, dorsal root ganglia and also foetal and adult brain. There are 6 different isoforms of tau in adult brain which is a result of alternative splicing of mRNA.
Tau is a hydrophilic, soluble unfolded protein which has a molecular mass of 36-45 kDa. It is 90nm in length and is rod shaped. It consists of up to 352-431 amino acids which join via peptide bonds to form the polypeptide. As it is a protein it has an N terminal (NH2 group) and a C terminal (COOH group) which contributes to its ability to promote microtubule assembly.
The C terminal contains a conserved binding domain which is 55nm in length and is composed of either 3 repeats of 18 positively charged amino acids (foetal brain) or 4 repeats (adult brain located between 237-367 amino acid). These repeats align alongside the microtubules and are separated by 13/14 amino acid linkers.
The linkers, who do not themselves bind to the microtubules, serve a function in positioning the binding repeats on the microtubule. They also give tau's structure a degree of flexibility and could help limit microtubule assembly as it enables tau to displace from the microtubules more easily than if the whole region was bound to it.
The role of the repeats is to bind tau to the tubulin in microtubules. It is in these repeat regions where there is highest affinity and free energy is delocalised (-10.7kCal/mole) leading to a great degree of binding. The high affinity is due to weak interactions between small amino acid groups, such as van der walls forces and ionic attractions. On each residue addition, the binding energy increases by 0.336kj/mole as interactions increase. Therefore adult brain which is composed of 4 repeats is more strongly bound to microtubules that foetal brain which may increase microtubule assembly. They way in which it does this is not fully understood, but we know that microtubule assembly requires a critical concentration of tubulin to be above and that tubulin will only bind to the +ve end of the microtubules if it is capped by stable GTP. Thus tau may bind to the alpha beta tublin and prevent the hydrolysis of beta GTP bound tubulin to unstable GDP which would cause the depolymerisation of tubulin and for microtubule subunits to disassemble from the -ve end. Therefore as long as there is no hydrolysis of beta GTP bound tubule the cap tubulin can polymerize onto the end, leading to microtubule growth. Tau is therefore present in cell bodies so that microtubule assembly can occur so that it projects out to form the axonal core for vesicle and organelle transportation.
Further upstream towards the n terminal is a proline-gylcine-glycine rich region which causes a sharp turn in the polypeptide which causes the N terminal to project away from the microtubule. It also increases the flexibility and elasticity of tau which contributes to its thermodynamic stability.
There is also a site which is targeted by protein kinases in the cell which form part of the intracellular signalling cascade. The site is thus known as a phoshorylation site and is called KSP as it is rich in serine lysine and proline which undergo phosphorylation. When this occurs the structure of tau changes and it can no longer bind to microtubules, therefore assembly decreases and reduction in depolymerisation is no longer reduced. This could lead to possible shrinking of the microtubules as the stable beta GTP tubulin cap could be hydrolysed so no more tubulin polymerization can take place and subsequently subunits are lost at a greater rate and the microtubule disassembles. This could decrease cytoskeleton stability and transport within the cells.
The n terminal is a nonbinding short projection that points away from the microtubules. It binds the microtubule to other cell components such as other microtubules/actin. Therefore tau plays a role in increasing the cytoskeletons stability. The free energy of the total protein is 4.4 fold smaller than when just the binding domain is considered, indicating the n terminal region can modulate binding of tau to the microtubule therefore decreasing rate of assembly.
Over expression of the gene coding for tau has been reported to cause neurofribrilar aggregation in Alzheimers patients, possibly due to too much tau, thus too many interactions between fibrils in the brain leading to aggregation. Therefore tau also plays an important function in disease states.
Unlike tau, stathmin is a phosphoprotein coded by the stathmin gene on the p arm of chromosome 1 and is a moledcular weight of 17kDa. It targets free tubulin in cells and sequesters it, reducing tubulins ability to polymerize onto the end of microtubules, thus decreasing its ability to grow. Stathmin is therefore very important in controlling microtubule dynamics especially in cell cycle which will be explored later.
Stathmin contains 60% helical structure at its c terminus which initiates at Lys 41- 75. The alpha helix is 14nm in and is composed of 90 amino acids forming a rod shape. Stathmin therefore has a secondary structure which does not appear to be present in tau. Based on knowledge of alpha helix, it is either right/left handed coil with a polypeptide backbone with the hydrophilic amino acid side chains extending out. The coil is stabilized by electrostatic attraction, disulphide bonds and van der walls forces. Most of all, hydrogen bonding that lye's parallel to the axis and forms between the C=0 group and the N-H group of another amino acid 4 resides later, makes the helix stable. There are 3.6 residues per turn. The helix is the region (stathmin like domain SLD) that binds the protein to the microtubule. Upon binding a stable curved T2S complex is formed. This is a ternary complex formed from 1 mole of stathmin to 2 moles of tublin in a head to tail arrangement. The curved nature of the complex and the formation of the heterodimer, inhibits tubulins ability to add to the +ve end of the microtubule and polymerize, thus microtubule growth is reduced and rate of GTP hydrolysis could overtake, leading to microtubule shrinkage. Stathmins ability to do this means it plays an important role in the cell cycle as high levels of stathmin promotes rapid shrinking of the mitotic spindle formed from microtubles, enabling cell division. Thus stathmin plays a role in cell division
Intraceullar protein kinases also target stathmin by phosphorylating 4 residues ( SER 16, 25, 38, 63). Phosphorylation of this amino acids cause conformational change in the protein as the SLD region changes from a structures helix to a random coil, leading to a 10 fold decrease in binding to tubulin. Therefore there is more free tubulin which can add and ploymerize to the beta GTP stable +ve end of the microtubule, leading to mictrobule aseembly. The phosphoylated stathmin therefore has an important function in creating the mitotic spindle that radiate out from the centrosomes from either end of the cell so that daughter chromosomes can be pulled apart and separated so cell division and cell pliferation can take place.
In fact, it has been reported that over expression of this gene perhaps due to mutation,can increase risk of some caners such as breast cancer. In 50 primary breast tumours, 35 showed over expression of the gene, 5 of which showed 6 times the normal levels of stathmin. Unphosphorylated stathmin therefore can lead to uncontrollable microtubule turn over and cell proliferation which is seen in cancerous cells. However, if stathmin could be manipulated so that it either does / does not phosphorylate then it could be used as a therapeautic agent to treat cancer as microtubule assembley and disaasembly cant take place thus the mitotic spindles could not function properly leading to reduced uncontrollable cell proliferation.