text:
Norepinephrine transporter
|VALUE_ERROR (nil)
|External IDs
|GeneCards: [1]
|RefSeq (mRNA)
|RefSeq (protein)
|Location (UCSC)
|PubMed search
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.[1]
NET is a monoamine transporter and is responsible for the sodium-chloride (Na+/Cl−)-dependent reuptake of extracellular norepinephrine (NE), which is also known as noradrenaline. NET can also reuptake extracellular dopamine (DA). The reuptake of these two neurotransmitters is essential in regulating concentrations in the synaptic cleft. NETs, along with the other monoamine transporters, are the targets of many antidepressants and recreational drugs. In addition, an overabundance of NET is associated with ADHD.[2][3] There is evidence that single-nucleotide polymorphisms in the NET gene (SLC6A2) may be an underlying factor in some of these disorders.[3]
The norepinephrine transporter gene, SLC6A2 is located on human chromosome 16 locus 16q12.2. This gene is encoded by 14 exons.[3] Based on the nucleotide and amino acid sequence, the NET transporter consists of 617 amino acids with 12 membrane-spanning domains. The structural organization of NET is highly homologous to other members of a sodium/chloride-dependent family of neurotransmitter transporters, including dopamine, epinephrine, serotonin and GABA transporters.[3]
Single nucleotide polymorphisms
A single-nucleotide polymorphism (SNP) is a genetic variation in which a genome sequence is altered by a single nucleotide (A, T, C or G). NET proteins with an altered amino acid sequence (more specifically, a missense mutation) could potentially be associated with various diseases that involve abnormally high or low plasma levels of norepinephrine due to altered NET function. NET SNPs and possible associations with various diseases are an area of focus for many research projects. There is evidence suggesting a relationship between NET SNPs and various disorders such as ADHD[3][4] psychiatric disorders,[3] postural tachycardia[3][5] and orthostatic intolerance.[3][5] The SNPs rs3785143 and rs11568324 have been related to attention-deficit hyperactivity disorder.[6] Thus far, however, the only confirmed direct association between a SNP and a clinical condition is that of the SNP, Ala457Pro, and orthostatic intolerance.[3] Thirteen NET missense mutations have been discovered so far.[3]
|Amino Acid Variant
|TMD (if known)
|Related Disease
|Exon 2
|Exon 3
|Exon 5
|Exon 6
|Exon 8
|Exon 8
|Exon 8
|Exon 10
|Exon 10
|Orthostatic intolerance
|Exon 10
|Exon 11
|Exon 12
|Exon 13
For the table above, refer to this table of standard amino acid abbreviations. This notation for
missense mutations, take Val69Ile for example, indicates that amino acid Val69 was changed to Ile.
Genetic variations
An epigenetic mechanism (hypermethylation of CpG islands in the NET gene promoter region) that results in reduced expression of the noradrenaline (norepinephrine) transporter and consequently a phenotype of impaired neuronal reuptake of norepinephrine has been implicated in both postural orthostatic tachycardia syndrome and panic disorder.[8]
The norepinephrine transporter is composed of 12 transmembrane domains (TMDs). The intracellular portion contains an amino (-NH
2) group and carboxyl (-COOH) group. In addition, there is a large extracellular loop located between TMD 3 and 4.[9][2][10] The protein is composed of 617 amino acids.[9]
NET functions to transport synaptically released norepinephrine back into the presynaptic neuron. As much as 90% of the norepinephrine released will be taken back up in the cell by NET. NET functions by coupling the influx of sodium and chloride (Na+/Cl−) with the transport of norepinephrine. This occurs at a fixed ratio of 1:1:1.[11] Both the NET and the dopamine transporter (DAT) can transport norepinephrine and dopamine. The reuptake of norepinephrine and dopamine is essential in regulating the concentration of monoamine neurotransmitters in the synaptic cleft. The transporter also helps maintain homeostatic balances of the presynaptic neuron.[12]
Norepinephrine (NE) is released from noradrenergic neurons that innervate both the CNS and PNS. NE, also known as noradrenaline (NA), has an important role in controlling mood, arousal, memory, learning, and pain perception. NE is a part of the sympathetic nervous system.[2][13] Dysregulation of the removal of norepinephrine by NET is associated with many neuropsychiatric diseases, discussed below. In addition, many antidepressants and recreational drugs compete for the binding of NET with NE.[9]
Transport mechanisms
The transport of norepinephrine back into presynaptic cell is made possible by the cotransport with Na+ and Cl−. The sequential binding of the ions results in the eventual reuptake of norepinephrine. The ion gradients of Na+ and Cl− make this reuptake energetically favorable. The gradient is generated by the Na+/K+-ATPase which transports three sodium ions out and two potassium ions into the cell.[12] NETs have conductances similar to those of ligand-gated ion channels. The expression of NET results in a leak-channel activity.[11][12]
Location in the nervous system
NETs are restricted to noradrenergic neurons and are not present on neurons that release dopamine or epinephrine.[2][10][12] The transporters can be found along the cell body, axons, and dendrites of the neuron.[2] NETs are located away from the synapse, where norepinephrine is released. They are found closer to the plasma membrane of the cell. This requires norepinephrine to diffuse from the site it is released to the transporter for reuptake.[12] Norepinephrine transporters are confined to the neurons of the sympathetic system, and those innervating the adrenal medulla, lung, and placenta.[12]
Regulation of NET function is complex and a focus of current research. NETs are regulated at both the cellular and molecular level post-translation. The most understood mechanisms include phosphorylation by the second messenger protein kinase C (PKC).[10] PKC has been shown to inhibit NET function by sequestration of the transporter from the plasma membrane.[14] The amino acid sequence of NET has shown multiple sites related to protein kinase phosphorylation.[12] Post-translational modifications can have a wide range of effects on the function of the NET, including the rate of fusion of NET-containing vesicles with the plasma membrane, and transporter turnover.[14]
Clinical significance
Orthostatic intolerance
Orthostatic intolerance (OI) is a disorder of the autonomic nervous system (a subcategory of dysautonomia) characterized by the onset of symptoms upon standing. Symptoms include fatigue, lightheadedness, headache, weakness, increased heart rate/heart palpitations, anxiety, and altered vision.[3] Often, patients have high plasma norepinephrine (NE) concentrations (at least 600 pg/ml) in relation to sympathetic outflow upon standing, suggesting OI is a hyperadrenergic condition.[3][5] The discovery of identical twin sisters both suffering from OI suggested a genetic basis for the disorder.[3][5] A missense mutation on the NET gene (SLC6A2) was discovered in which an alanine residue was replaced with a proline residue (Ala457Pro) in a highly conserved region of the transporter.[3] The patients' defective NET had only 2% of the activity of the wild-type version of the gene.[3] The genetic defect in the NET protein results in decreased NET activity that could account for abnormally high NE plasma levels in OI. However, 40 other OI patients did not have the same missense mutation, indicating other factors contributed to the phenotype in the identical twins.[3] This discovery of the linkage with NET mutations that results in decreased norepinephrine reuptake activity and orthostatic intolerance suggests faulty NE uptake mechanisms can contribute to cardiovascular disease.[15]
Therapeutic uses
Inhibition of the norepinephrine transporter (NET) has potential therapeutic applications in the treatment of attention deficit hyperactivity disorder (ADHD), substance abuse, neurodegenerative disorders (e.g., Alzheimer's disease (AD) and Parkinson's disease (PD)) and clinical depression.[13]
Major depressive disorder
Certain antidepressant medications act to raise noradrenaline, such as serotonin-norepinephrine reuptake inhibitors (SNRIs), norepinephrine-dopamine reuptake inhibitors (NDRIs), norepinephrine reuptake inhibitors (NRIs or NERIs) and the tricyclic antidepressants (TCAs). The mechanism by which these medications work is that the reuptake inhibitors prevent the reuptake of serotonin and norepinephrine by the presynaptic neuron, paralyzing the normal function of the NET. At the same time, higher levels of 5-HT are maintained in the synapse increasing the concentrations of the latter neurotransmitters. Since the noradrenaline transporter is responsible for most of the dopamine clearance in the prefrontal cortex,[16] SNRIs block reuptake of dopamine too, accumulating the dopamine in the synapse. However, DAT, the primary way dopamine is transported out of the cell, can work to decrease dopamine concentration in the synapse when the NET is blocked.[17] For many years, the number one choice in treating mood disorders like depression was through administration of TCAs, such as desipramine (Norpramin), nortriptyline (Arentyl, Pamelor), protriptyline (Vivactil) and amoxapine (Asendin).[13] SSRIs, which mainly regulate serotonin, subsequently replaced tricyclics as the primary treatment option for depression because of their better tolerability and lower incidence of adverse effects.[18]
Many drugs exist in the treatment of ADHD. Dextroamphetamine (Dexedrine, Dextrostat), Adderall, methylphenidate (Ritalin, Metadate, Concerta, Daytrana), and lisdexamfetamine (Vyvanse) block reabsorption of the catecholamines dopamine and norepinephrine through monoamine transporters (including NET), thereby increasing levels of these neurotransmitters in the brain. The strong selective norepinephrine reuptake inhibitor (NRI), atomoxetine (Strattera), has been approved by the U.S. Food and Drug Administration (FDA) to treat ADHD in adults.[19][20] The role of the NET in ADHD is similar to how it works to ease the symptoms of depression. The NET is blockaded by atomoxetine and increases NE levels in the brain. It can work to increase one's ability to focus, decrease any impulsiveness, and lessen hyperactivity in both children and adults who suffer from ADHD.[21]
Cocaine is a powerful psychostimulant and known to be one of the most widely abused substances.[22] Cocaine is a nonselective, reuptake inhibitor of the norepinephrine, serotonin, and dopamine transporters. This thwarts the absorption of these chemicals into the presynaptic terminal[22] and allows a large concentration of dopamine, serotonin and norepinephrine to build up in the synaptic cleft. The potential for cocaine addiction is thought to be a result of its effects on dopamine transporters in the CNS, while it has been suggested that the life-threatening cardiovascular effects of cocaine may involve the inhibition of NETs at sympathetic and CNS autonomic synapses.[23]
Amphetamines have an effect on norepinephrine levels similar to that of cocaine in that they both increase NE levels in the brain.[24] Amphetamine-like drugs are substrates for monoamine transporters, include NET, that cause a reversal in the direction of neurotransmitter transport.[12][25] Amphetamines cause a large accumulation of extracellular NE.[24] High levels of NE in the brain account for most of the profound effects of amphetamines, including alertness and anorectic, locomotor and sympathomimetic effects.[24] However, the effects that amphetamines have on the brain are slower but last longer than the effects cocaine has on the brain.[24] MDMA (3,4-Methylenedioxymethamphetamine or "ecstasy") is an amphetamine with wide recreational use. A study reported that the NET inhibitor reboxetine reduced the stimulant effects of MDMA in humans, demonstrating the crucial role NET has in the cardiovascular and stimulant-like effects of MDMA.[26]
Further research
The role of the NET in many brain disorders underlies the importance of understanding the (dys)regulation of the transporter. A complete model of the proteins that associate with the transporter will be useful in designing drug therapies for diseases such as schizophrenia, affective disorder, and autonomic disorders. Recently discovered mechanisms of the NET, including the ability to act reversibly and as an ion channel, provide other areas of research.[10][12]
The role of NE in schizophrenia has not been fully understood, but has stimulated research into this topic.[27][28][29][30] The only relationship that has been understood between researchers is that there is a positive correlation between increased NE levels in the brain and spinal fluid (CSF) and activity of schizophrenia.[27][28][29][30] In one study, clonidine, a drug used to treat medical conditions such as ADHD and high blood pressure, was shown to produce a significant decrease in plasma level MHPG (3-methoxy-4-hydroxyphenylglycol), a metabolite of NE, in the normal control group, but not in the group of schizophrenic patients.[29] This suggests that in schizophrenia, the alpha-2 adrenergic receptor, a presynaptic inhibitory receptor, may be less sensitive compared to normally functioning alpha-2 receptors and thus relate to elevated NE levels in the disorder.[29] In addition to increased NE levels in the brain and CSF, increased levels of MHPG has also been associated with a diagnosis of schizophrenia.[30] Impaired NE regulation in schizophrenia has been an area of interest for researchers and research on this topic is still ongoing.[29][30]
Via positron emission tomography imaging technique, NET has been selectively investigated. 11C ME@HAPTHI and 18F-MeNER are two NET selective radio tracers for PET imaging.[31]
See also
- Neurotransmitter transporter
- Sodium:neurotransmitter symporter
- Solute carrier family
- Norepinephrine
- Monoamine transporter
- Orthostatic intolerance
- Single-nucleotide polymorphisms
- ↑ Pacholczyk T, Blakely RD, Amara SG (Mar 1991). "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter". Nature. 350 (6316): 350–4. doi:10.1038/350350a0. PMID 2008212.
- ↑ 2.0 2.1 2.2 2.3 2.4 Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD (May 2000). "Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter". The Journal of Comparative Neurology. 420 (2): 211–32. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3. PMID 10753308.
- ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 Tellioglu T, Robertson D (Nov 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Reviews in Molecular Medicine. 2001 (29): 1–10. doi:10.1017/S1462399401003878. PMID 14987367.
- ↑ Kim CH, Hahn MK, Joung Y, Anderson SL, Steele AH, Mazei-Robinson MS, Gizer I, Teicher MH, Cohen BM, Robertson D, Waldman ID, Blakely RD, Kim KS (Dec 2006). "A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder". Proceedings of the National Academy of Sciences of the United States of America. 103 (50): 19164–9. doi:10.1073/pnas.0510836103. PMC 1748193. PMID 17146058.
- ↑ 5.0 5.1 5.2 5.3 Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D (Feb 2000). "Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency". The New England Journal of Medicine. 342 (8): 541–9. doi:10.1056/NEJM200002243420803. PMID 10684912.
- ↑ Kim JW, Biederman J, McGrath CL, Doyle AE, Mick E, Fagerness J, Purcell S, Smoller JW, Sklar P, Faraone SV (Jun 2008). "Further evidence of association between two NET single-nucleotide polymorphisms with ADHD". Molecular Psychiatry. 13 (6): 624–30. doi:10.1038/sj.mp.4002090. PMID 17876324.
- ↑ Maarten E. A. Reith (2002). Neurotransmitter transporters: structure, function, and regulation. Humana Press. p. 120. ISBN 978-0-89603-945-2. Retrieved 27 October 2011.
- ↑ Esler M, Alvarenga M, Pier C, Richards J, El-Osta A, Barton D, Haikerwal D, Kaye D, Schlaich M, Guo L, Jennings G, Socratous F, Lambert G (Jul 2006). "The neuronal noradrenaline transporter, anxiety and cardiovascular disease". Journal of Psychopharmacology. 20 (4 Suppl): 60–6. doi:10.1177/1359786806066055. PMID 16785272.
- ↑ 9.0 9.1 9.2 Stöber G, Nöthen MM, Pörzgen P, Brüss M, Bönisch H, Knapp M, Beckmann H, Propping P (Nov 1996). "Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders". American Journal of Medical Genetics. 67 (6): 523–32. doi:10.1002/(SICI)1096-8628(19961122)67:6<523::AID-AJMG3>3.0.CO;2-I. PMID 8950409.
- ↑ 10.0 10.1 10.2 10.3 Sager JJ, Torres GE (Aug 2011). "Proteins interacting with monoamine transporters: current state and future challenges". Biochemistry. 50 (34): 7295–310. doi:10.1021/bi200405c. PMID 21797260.
- ↑ 11.0 11.1 Galli A, DeFelice LJ, Duke BJ, Moore KR, Blakely RD (Oct 1995). "Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants". The Journal of Experimental Biology. 198 (Pt 10): 2197–212. PMID 7500004.
- ↑ 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 12.8 Torres GE, Gainetdinov RR, Caron MG (Jan 2003). "Plasma membrane monoamine transporters: structure, regulation and function". Nature Reviews. Neuroscience. 4 (1): 13–25. doi:10.1038/nrn1008. PMID 12511858.
- ↑ 13.0 13.1 13.2 Zhou J (Dec 2004). "Norepinephrine transporter inhibitors and their therapeutic potential". Drugs of the Future. 29 (12): 1235–1244. doi:10.1358/dof.2004.029.12.855246. PMC 1518795. PMID 16871320.
- ↑ 14.0 14.1 Gether U, Andersen PH, Larsson OM, Schousboe A (Jul 2006). "Neurotransmitter transporters: molecular function of important drug targets". Trends in Pharmacological Sciences. 27 (7): 375–83. doi:10.1016/j.tips.2006.05.003. PMID 16762425.
- ↑ Schroeder C, Tank J, Boschmann M, Diedrich A, Sharma AM, Biaggioni I, Luft FC, Jordan J (Jan 2002). "Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance". Circulation. 105 (3): 347–53. doi:10.1161/hc0302.102597. PMID 11804991.
- ↑ Morón JA, Brockington A, Wise RA, Rocha BA, Hope BT (Jan 2002). "Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines". The Journal of Neuroscience. 22 (2): 389–95. PMID 11784783.
- ↑ Yavich L, Forsberg MM, Karayiorgou M, Gogos JA, Männistö PT (Sep 2007). "Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum". The Journal of Neuroscience. 27 (38): 10196–209. doi:10.1523/JNEUROSCI.0665-07.2007. PMID 17881525.
- ↑ Clinical Pharmacology of SSRI's: How SSRIs as a Group Differ From TCAs, Preskorn
- ↑ "What medications are used to treat ADHD?". National Institutes of Mental Health.
- ↑ Simpson D, Plosker GL (2004). "Atomoxetine: a review of its use in adults with attention deficit hyperactivity disorder". Drugs. 64 (2): 205–22. doi:10.2165/00003495-200464020-00005. PMID 14717619.
- ↑ "Atomoxetine -". PubMed Health. Retrieved 2 November 2011.
- ↑ 22.0 22.1 Macey DJ, Smith HR, Nader MA, Porrino LJ (Jan 2003). "Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey". The Journal of Neuroscience. 23 (1): 12–6. PMID 12514195.
- ↑ Barker EL, Blakely RD (1995). "Norepinephrine and Serotonin Transporters". In Kupfer DJ, Bloom FE. Psychopharmacology: the fourth generation of progress. New York: Raven Press. ISBN 0-7817-0166-X. Retrieved 2 November 2011.
- ↑ 24.0 24.1 24.2 24.3 Drug and Human Performance Fact Sheets. "Methamphetamine (And Amphetamine)". Retrieved 1 November 2011
- ↑ Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A (May 1995). "Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport". The Journal of Neuroscience. 15 (5 Pt 2): 4102–8. PMID 7751968.
- ↑ Hysek CM, Simmler LD, Ineichen M, Grouzmann E, Hoener MC, Brenneisen R, Huwyler J, Liechti ME (Aug 2011). "The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA ("ecstasy") in humans". Clinical Pharmacology and Therapeutics. 90 (2): 246–55. doi:10.1038/clpt.2011.78. PMID 21677639.
- ↑ 27.0 27.1 Decaire, Michael. "The neurophysiology of schizophrenia: Etiology and Psychopharmacological treatment". Retrieved 1 November 2011
- ↑ 28.0 28.1 Breier A, Wolkowitz OM, Roy A, Potter WZ, Pickar D (Nov 1990). "Plasma norepinephrine in chronic schizophrenia". The American Journal of Psychiatry. 147 (11): 1467–70. doi:10.1176/ajp.147.11.1467. PMID 2221157.
- ↑ 29.0 29.1 29.2 29.3 29.4 Sternberg DE, Charney DS, Heninger GR, Leckman JF, Hafstad KM, Landis DH (Mar 1982). "Impaired presynaptic regulation of norepinephrine in schizophrenia. Effects of clonidine in schizophrenic patients and normal controls". Archives of General Psychiatry. 39 (3): 285–9. doi:10.1001/archpsyc.1982.04290030025004. PMID 6279049.
- ↑ 30.0 30.1 30.2 30.3 van Kammen DP, Antelman S (Apr 1984). "Impaired noradrenergic transmission in schizophrenia?". Life Sciences. 34 (15): 1403–13. doi:10.1016/0024-3205(84)90054-7. PMID 6323903.
- ↑ Rami-Mark C, Berroterán-Infante N, Philippe C, Foltin S, Vraka C, Hoepping A, Lanzenberger R, Hacker M, Mitterhauser M, Wadsak W (Dec 2015). "Radiosynthesis and first preclinical evaluation of the novel norepinephrine transporter pet-ligand [(11)C]ME@HAPTHI". EJNMMI Research. 5 (1): 113. doi:10.1186/s13550-015-0113-3. PMC 4467816. PMID 26061602.
External links
- Norepinephrine+transporter at the US National Library of Medicine Medical Subject Headings (MeSH)


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SONG OF SONGS: 2. I would lead you, I would bring you to the house of my mother, who instructed me; I would give you to drink some spiced wine, of the juice of my pomegranate.
70 SOULS THAT DESCENDED TO EGYPT: Arodi and Naaman
TALMUD SHEVUOTH: Daf 40 – Returning Disputed Items
BOOK OF JEREMIAH: Chapter 40
Week 40 in the Jewish calendar is the second week of Tammuz. The verse of Shir HaShirim of this week makes reference to the Temple, calling it "the house of my mother." (See Rashi) The month of Tammuz is very much connected to exile and the destruction of the Temple. The number forty is the gematria of the letter Mem and next week, 41, is the gematria of Alef Mem, which spells, Em, mother. The verse also mentions the pomegranate, and this period of the year is connected to the pomegranate in Perek Shirah (See Book 6).
Of the seventy souls of the Jewish people that descended to Egypt, the fortieth mentioned is Arodi. The name seems related to the verb to descend, Lered, which is also connected to exile. This week is also connected to Naaman, son of Benjamin, whose means pleasant, a reference to how Joseph's deeds were "seemly and pleasant." Like Joseph, we must hold fast to the ways of righteousness, even in exile.
Daf Mem (Folio 40) of Shvuot describes admission related to paying someone back. Interestingly, this is related to Book 1, Week 40, in which the Wolf decries stealing – the wolf specifically mentions, "the ox, the donkey, the lamb, the garment, for every lost item" and the daf too, discusses all sorts of of items in dispute, including ox, sheep, vessels, land, etc. Again, the focus is on maintaining our moral standards, even in exile.
Chapter 40 of the Book of Jeremiah contains a similar theme to the above. It introduces the leader Gedaliah, a righteous leader. Because of Gedaliah's righteousness, despite the great destruction that befell us, life is able to regain some degree of normalcy.
9. And Gedaliah the son of Ahikam the son of Shaphan swore to them and to their men, saying, "Fear not to serve the Chaldeans. Dwell in the land and serve the king of Babylon, and it will go well with you.
10. And I, behold I dwell in Mizpah to stand before the Chaldeans who will come to us, and you gather wine and dried figs and oil and put [them] into your vessels and dwell in your cities, which you have taken.
11. And also, all the Jews who [were] in Moab and among the children of Ammon and in Edom and who [were] in all the lands, heard that the king of Babylon had given Judah a remnant and that he had appointed over them Gedaliah the son of Ahikam the son of Shaphan.
12. And all the Jews returned from all the places they had been driven, and they came to the land of Judah to Gedaliah to Mizpah, and they gathered very much wine and dried figs.
Gedaliah was also so righteous that he refused to believe that another leader would attempt to assassinate him.
16. And Gedaliah the son of Ahikam said to Johanan the son of Kareah, "Do not do this thing for you speak falsely about Ishmael."

subset: commoncrawl


text:
News & Buzz
Grasshopper is everywhere
Grasshopper on CBS 3 News
As a journalist, I am the recipient of occasional promotional objects that raise an eyebrow — cell phones with odd keypads, tie-dyed tee-shirts and the like. And who can forget the anti-virus software company that sent out condoms as a way to promote security?
But creative marketing folks of New England take note, the weirdness bar has just been raised. Last week I received a package of chocolate covered grasshoppers.
The sweet insects came in a very professional package — an important element when receiving random food products via Federal Express — that indicated they were from a company called Grasshopper.com and that enclosed therein were, indeed, chocolate covered grasshoppers. "Approved by the FDA of Thailand," said the envelope, as if that would be a deciding factor in whether or not I would actually ingest one.
Grasshopper.com, it turns out, is in fact Needham-based GotVMail Communications LLC, a maker of communication systems for small businesses and an old Mass High Tech acquaintance, which was profiled here back in 2005. The promotion is aimed at announcing the company's name change to Grasshopper Group, but officials also said the company is launching a new theme targeting entrepreneurs, or more accurately, entrepreneurship.
"After six years of growing GotVMail, we took a step back and said 'we want to be more,'" said CEO and co-founder Siamak Taghaddos. "We didn't want to just be a telecommunications company, but a company that helped entrepreneurs."
Taghaddos and his team took the idea and decided to build an entire brand around the idea of helping entrepreneurs, not just on the communications side, but in terms of inspiration as well. The chocolate treats also came with a web address, which plays a nice video, encouraging entrepreneurship.
"It wasn't just about mailing something to people to build our own name," said Taghaddos. "It's about fixing the economy and the entrepreneurial community."
As marketing plans go, the promotion is certainly unique, and has been successful in at least creating buzz around the company's name change. Grasshopper sent out 5,000 of the packages to "top influencers," including politicians and press. (President Obama got a package, though the guess here is that strange, unsolicited edibles probably have a complicated journey through security at the White House). As a result, the "Twitter-verse," blogosphere and other social networking realms have been abuzz about the grasshoppers, and the company has gotten plugs in major news outlets, including Fox News.
The grasshopper, said officials, elicits the idea of jumping forward — the little critters can jump 20 times their own size, which is akin to me jumping about 120 feet. Every small business wants to jump forward, and Taghaddos and his team want to encourage customers to do so.
But the buzz surrounding crickets and their consumption with cocoa has overshadowed the fact that the company has also made advances in its product offering. What began in 2003 as essentially a virtual private branch exchange has been integrated with online communications features, creating a fully functioning, large-company telephony system for a small business. As GotVMail, the company boasted about 70,000 customers, but officials said the marketing campaign has drawn a whole new batch of interest and expanded the company's geographic reach nationwide and beyond.
In the end, Taghaddos and co-founder and CTO David Hauser are entrepreneurs themselves, and their bold — possibly risky — marketing campaign seems to be paying off.
GotVMail, a brand that arguably had become stale, has gained a new life as Grasshopper, at a time when the economy is starved for success stories and looking to entrepreneurs, rather than large companies, to help bring innovation back to small business.
All on the back of farm-raised insects dipped in chocolate.


text:
Elephant Soft Toy
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text:
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This is a retrospective about the Human Aquarium. Words by Lucy Meredith
Human Aquarium Exhibition was created by Yorkshire Life Aquatic in February 2019. One of the things we do, is use art to tackle environmental issues. Firstly we looked at the consequences of animal captivity, and after that, we put our attention toward single-use plastics. Most importantly, we linked these single issues back to the impact it has for people.
Firstly, we were really worried about the volume of single-use plastics used in Leeds. Secondly, we were aware that a lot of this waste could not be recycled. This is a problem. In contrast, we wanted to create a project that promoted the ideas of re-using materials and up cycling. More importantly, we wanted to create fun ways to do this.
It is especially relevant in land-locked cities such as Leeds as people may simply not see the impact of these issues on the environment. The Human Aquarium was a way of getting people to think about their plastic use in an interesting and visual way. This is because art and creativity are powerful ways to provoke curiosity and interest from people about challenging subjects.
The Aquarium | How we transformed the space
We took over an empty shop in the St John's shopping centre and transformed it into this aquarium. We worked with lighting and set designers so that we could do this. The aim was to create an interactive exhibition that people could immerse themselves within. We created sculptures and installations made from single use plastics. We used the lighting and set designs to evolve a multi- sensory and child friendly space. Visitors were able to explore it freely and safely.
After that, we worked with a photographer to create thought provoking images. The photos told a narrative of sea mammals and their captivity. The story put people in the places of dolphins and orcas. Similarly, the underwater film told this story of captivity. What is it like to live in a tank?
Preparation | What we did Before the Project
In preparation, we collected thousands of used plastic bottles which formed plastic trash islands within the space. We also worked with a local group Plastic-Free Me. They worked with young people to create a giant octopus that lit up. It represented the amount of rubbish one person makes in just one month. Visitors found this information really surprising. As well as this, we collaborated with many Leeds-based artists, makers and students from Leeds Arts University. We found this exciting.
Over the 12 day exhibition, we had a massive 7642 visitors to the space. We ran 12 creative workshops and talks. We sold out on our environmental talks night. Hence, we can surmise that people really do care about what's happening to our planet.
What is noteworthy is that the exhibition proved to be a major success and as a result, we are planning our next steps. Would you like the exhibition to pop up in your town? Do let us know if you would.
Feedback | Comments from visitors
"Incredibly inspiring and such an important message. I am so proud of the exhibition because this is what's going to make a change."
"An inspiring, resourceful and wonderful exhibition. It made us think about what we could do to save our world. Thank you."
"What an AMAZING exhibition. It had a beautiful energy and also felt mysterious. It made serious points that made me think about the environment and the impact I have. I believe that it was much better and more effective than preaching with a public information leaflet."
Twitter @HumanAquariumUK


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We've chosen the best properties from our offer with perfect ratings, with the owners we prepared an individual offer and bookings made on these properties will be processed with the highest priority. » more
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IIT-Kharagpur Warns Arvind Kejriwal and Other Leaders
Students at IIT-Kharagpur have recently started an anti-AAP protest in the wake of the party's gaffes less than a month into ministry. The students' community at IIT-Kharagpur has also strictly warned the party to take care of its actions and other activities in near future.
Although over 400 students from IIT-Kharagpur volunteered for AAP to popularize it to other IITs in India, students have severely criticized AAP's current actions in Delhi to earn cheap popularity. This has led students to doubt over the party's future.
IIT-Kharagpur community has openly started criticizing AAP for its instinct in Delhi on its Facebook page called "IIT Against AAPâ€Â. The Facebook page already has 24,000 people following it.
"Honestly, we didn't for once think that Kejriwal would make these blatant mistakes immediately after assuming office. Why did he have to say that he had acrimonious documents against Sheila Dixit? Now why is he saying that a lot has to be investigated before making these public? We wonder why he had to assume power in the first place by taking the help of Congress?" Angshuman Chakraborty, an alumnus who runs his own software company, was quoted as saying.
"Who will run the administration if half the officials are suspended? One of the reasons for bribery is also that most government offices are understaffed or manned by incompetent staff. Suspensions cannot solve these problems," M.K. Badwar, an alumnus of the 1973 batch, said.
There is no denying that AAP's popularity after the controversy over Somnath Bharti's alleged vigilantism, Ugandan women visitors, and Kejriwal's Dharna.
"Instead of such gimmicks, the CM should look for mature long-term solutions. Why should the head of a state government advertise anarchy? He is taking the law in his own hands instead of using the law to solve issues," Anubhav Sinha, a student at IIT, said.
This post was published by Nishant Sinha, co-founder of askIITians.
- Excited
- Fascinated
- Amused
- Bored
- Sad
- Angry


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This issue marks the end of Volume 31 of the College Tribune. As the only self-funded student newspaper in Ireland, making it to the end of another year is always a success. By picking up a copy or reading online, you are continuing to support a tradition of independent journalism on campus that dates back to the paper's origin.
Last year's Tribune signed off with a piece on UCD's forgotten plans to build a five-storey car park by the Clonskeagh entrance. Coincidentally, this issue almost ended with another parking piece. It comes at a time when UCD has just applied to the Council to keep using the old running track as a car park. It now wants to formally mark out 335 spaces for up to five years.
Using the facility for parking has already been debated, but the demand for parking on campus has recently increased due to the removal of 50 spaces to serve as a storage site for the construction of the Private Club. Don't forget that the cost of permits will double to €100 next year, so drivers will be paying more to receive less.
But what's the point of all these news reports on parking and construction projects? Stories about what UCD is trying to build may not be the most interesting pieces to read, but they are vital if you want to better understand where the money goes. Take the lead piece in issue 9, for example. UCD spent over €10 million on consultation fees for the failed Gateway Project over a decade ago. It's coming back with a new name. Watch as the costs rack up for years before a shovel hits the ground.
UCD's administration states it has no money for student projects, but wants to carry out the most ambitious development of Belfield in decades. The location of Andrew Deeks' office may seem unimportant to students, yet the hundreds of thousands being spent to move it into Ardmore House is coming from university resources which could be used in a variety of ways. These may not be the stories we want to read, but they are the ones we need to follow. Here's to another 31 Volumes!
Cian Carton – Editor


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Sometimes, we get data that needs to be unique but we can also get NULL records. Existing ways to achieve uniqueness don't allow NULLs (Primary Key) or allow a maximum of one NULL (Unique Constraint). Let's take an example to understand this better. Suppose, you have an Employee table with fields like Id, FirstName, MiddleName, LastName, Email, etc. As per the requirement, the email needs to be unique (if supplied), however, users are also allowed to register without entering their email and hence in the database Email is a nullable field. So, how would you achieve the Email uniqueness having more than one NULL? CREATE UNIQUE NONCLUSTERED INDEX [UX_Employee_Email] ON [dbo].Employee WHERE Email IS NOT NULL The above code will ensure that the Email doesn't have duplicate data, however, it may store more than one NULL.
OnceSQL Server Full-Text Search with rank values I wrote a post titled enabling Fulltext search in Azure SQL database discussing Full-Text search in Azure. while using it with one of my databases, needed to show the result of the search ordered by however well they match to the search criteria. in order to sort the result as i need, the best is, get a rank generated for every row and use it for ordering the result. I had used Freetext operate for obtaining the result but if i realized that this can not be achieved using the Freetext function.
The CONTAINSTABLE and FREETEXTTABLE functions return a column named Rank for showing the rank related to the record based on matching. this can be used get the result sorted based on it, showing most relevant records at the top. Remember, the higher value of the Rank generated indicates the best matching.Now, write the following code:view plainprint? -- Creating a table CREATE TABLE dbo.EmployeeDetails ( EmployeeDetailsId int identity(1,1) not null , constraint pk_EmployeeDetails primary key (EmployeeDetailsId) , WorkingExperience nvarchar(4000) not null , ProjectsWorked nvarchar(4000) not null , Resume nvarchar(max) ) GO CREATE FULLTEXT CATALOG EmployeeCatelog; GO CREATE FULLTEXT INDEX ON dbo.EmployeeDetails (WorkingExperience, ProjectsWorked, Resume) KEY INDEX pk_EmployeeDetails ON EmployeeCatelog; -- By default CHANGE_TRACKING = AUTO -- Once enabled, search can be performed; SELECT * FROM dbo.EmployeeDetails WHERE freetext ((WorkingExperience, ProjectsWorked, Resume), 'SQL'); SELECT * FROM dbo.EmployeeDetails WHERE freetext ((Resume), 'SQL'); -- Get the rank and sort the result using it SELECT t.Rank, e.* FROM dbo.EmployeeDetails e INNER JOIN CONTAINSTABLE (dbo.EmployeeDetails, (WorkingExperience, ProjectsWorked, Resume), 'SQL') AS t ON e.EmployeeDetailsId = t.[Key] ORDER BY t.Rank DESC
HostForLIFE.eu SQL 2016 HostingEuropean best, cheap and reliable ASP.NET hosting with instant activation. HostForLIFE.eu is #1 Recommended Windows and ASP.NET hosting in European Continent. With 99.99% Uptime Guaranteed of Relibility, Stability and Performace. HostForLIFE.eu security team is constantly monitoring the entire network for unusual behaviour. We deliver hosting solution including Shared hosting, Cloud hosting, Reseller hosting, Dedicated Servers, and IT as Service for companies of all size.
There are times when we need to pass a SQL query as a string that has been created dynamically and execute it on database or from the code. For this purpose, we can use a built-in stored procedure, sp_executesql.Stored procedure, sp_executesql executes a SQL statement or batch that can be reused many times, or one that has been built dynamically. Here is the syntax: sp_executesql [ @stmt = ] statement [ { , [ @params = ] N'@parameter_name data_type [ OUT | OUTPUT ][ ,...n ]' } { , [ @param1 = ] 'value1' [ ,...n ] } ] Here is an example where SQL is compiled as a string, str1. The SELECT SQL statement is executed via the string parameter passed to the sp_executesql.declare @str1 nvarchar(200) -----declare a variable set @str1='SELECT * FROM tablename' --- set your query to variable exec sp_executesql @str1
Here we will explain how to find the Indian financial year and financial quarter in a particular date with an example in SQL Server. I have used the CASE statement and DATEPART() function to achieve this requirement.
DATEPART() in SQL ServerThe DATEPART() function returns a specified part of a date, like – year, month, day, hour, minute, etc.CASE Statement in SQL ServerCASE is the extension of IF ... ELSE statement. So, once a condition is true, it will stop reading & return the result. If no conditions are true, it returns the value in the ELSE block. A) Find the FINANCIAL YEAR from date Write the below-given SQL code to find the financial year from given particular date, DECLARE@FilterDateASDATETIME SET@FilterDate = GETDATE() SELECTCASEWHENDATEPART(QUARTER,@FilterDate)= 1 THENYEAR(@FilterDate)ELSEYEAR(@FilterDate)+ 1 ENDAS[FINANCIAL_YEAR] ** Note - @FilterDate - The date to be find the financial year OutputFollowing is the result of the SQL query for financial year,
B) Find the FINANCIAL QUARTER from date Write the below SQL code to find the financial Quarter from given particular date, DECLARE@FilterDateASDATETIME SET@FilterDate = GETDATE() SELECTCASEDATEPART(QUARTER, @FilterDate)WHEN 1 THEN'Q4'WHEN 2 THEN'Q1'WHEN 3 THEN'Q2'WHEN 4 THEN'Q3'ENDAS[FINANCIAL_QUARTER] ** Note - @FilterDate - The date to be find the financial Quarter OutputFollowing is the result of the SQL query for the financial quarter,
In this post, I'll share few useful SQL queries for database analysis on SQL Server 2012. I shared few SQL queries useful in analyzing database, which I use quite often. This query will return all table names and no.of rows in it for built-in tables.
-- List all table names and number of rows in it for user-defined tables SELECT distinct t.name,prt.rows FROM sys.tables t INNER JOIN sys.partitions AS prt ON t.object_id = prt.object_id where t.is_ms_shipped=1 -- 0 for user-defined tables order by prt.rows desc This query will return column names and its data type of a table. -- Get column names and its types of a table SELECT cols.name,t.name FROM sys.objects o join sys.columns cols on o.object_id= cols.object_id join sys.types t on t.system_type_id=cols.system_type_id and o.name='Employee'-- Table NameThis query will return file name, its size and file group name of a database. SELECT sdf.name AS [FileName], size/128 AS [Size], fg.name AS [File_Group_Name] FROM sys.database_files sdf INNER JOIN sys.filegroups fg ON sdf.data_space_id=fg.data_space_id Batch file to execute all sql files in a directory, Save it as .bat in a folder that have sql script files to be executed. @Echo Off FOR /f %%i IN ('DIR *.Sql /B') do call :RunSql %%i GOTO :END :RunSql Echo Executing SQL: %1 SQLCMD -S server1 -U user1 -P pwd1 -d DB1 -i %1 Echo Completed SQL: %1 :END This query will return all table names that have a Foreign key: SELECT SCHEMA_NAME(schema_id) AS SchemaName, name AS TableName FROM sys.tables where OBJECTPROPERTY(OBJECT_ID,'TableHasForeignKey') = 1 -- Return all
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Children are going to fight, it's inevitable. Raising your family and your children with mutual respect for one another is great, but living in close quarters with someone will lead to getting on someone's nerves, and the pushing of buttons that will lead to an argument or a fight. Most of the time, fights between siblings are about wanting to play with a toy that the other is using, when playtime gets a little too intense, or something as simple as splitting a cookie. If you've had siblings growing up, you're familiar with how sibling fights arise. It is completely different, however, to experience sibling fights when they're your kids!
Keep reading to learn how to mediate your child's sibling fights, and when you've had enough kids for one day, contact us for inquiries about our preschool enrollment. With convenient preschool locations in Coon Rapids, Blaine, East Bethel, or Isanti, there is no reason not to enroll with us.
It's Normal
Your kids aren't monsters for fighting with each other. As a matter of fact, it is completely normal for them to have conflict. Every human relationship has conflict simply because every individual is unique and has their own set of needs. Sometimes two individuals need to play with the exact same stuffed animal at the same time. Just because sibling conflict is normal, however, doesn't necessarily mean that you are doomed for another couple years, or decade, of your kids screaming at each other while you cook dinner or drive them to school. There are plenty of things you can do to prevent conflict before it happens, and if it comes to it, help your children resolve the dispute by themselves.
Don't Take Sides
It is important to remember not to take sides, even if one child physically hurt the other. Once you have been looped into the conflict, your children are going to think that there is going to be a winner and a loser, which can create more hurt feelings between the children, and potentially even more fights. You don't want to give your children the idea that one of them is the troublemaker, but it is important to address the problem as soon as possible. Without shaming the child who started the fight or who physically escalated the fight, you need to be able to acknowledge their feelings but also set some limits. For example, if an older sibling hits their younger sibling because they grabbed a toy from their hands, you could say something like "You're mad that your brother grabbed your toy, but he doesn't understand that it's yours. Even if you feel upset, it is not O.K. to hit."
Give Siblings One-On-One Treatment
Eldest siblings may feel jealous or left out because younger siblings can sometimes get a little more attention. They can notice that they are no longer getting all the attention, which could potentially lead them to hold jealousy against the younger child. It is important to set up one-on-one time with older siblings, building a strong relationship with them, being sure not to show favoritism. This doesn't mean it needs to be equal all the time, but it is important to try to make things fair. Kids often notice the privileges of their siblings, and it feels painful.
Raising a child is never easy, and mediating fights between your children can be a lot harder than you would expect. You can stay updated on our blogs to learn more tips about certain aspects of raising kids, but remember raising children is a singular experience, and you're doing the best you can. Take some deep breaths, and if you need a preschool in Coon Rapids, Blaine, East Bethel, or Isanti, then contact us today.
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Once, there lived a very pious Hindu who always worshipped the Divine Mother and chanted Her name.
When the Mussalmans conquered the country, they forced him to embrace Islam. They said to him: "You are now a Mussalmans. Say 'Allah'. From now on you must repeat only the name of 'Allah'." With great difficulty he repeated the word 'Allah', but every now and then blurted out 'Jagadamba'. At that the Mussalmans were about to beat him. Thereupon he said to them: 'I beseech you! Please do not kill me. I have been trying my utmost to repeat the name of Allah, but our Jagadamba has filled me up to the throat. She pushes out your Allah".
It is not an easy thing to destroy old tendencies. (56)


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Portfolio Pulse: Asian Total Return Bond Fund
A pulse check on our Asian bond portfolio
A 3-minute video to explore the attractiveness of the Chinese bonds and the distinguished features of our Chinese bond strategy
In this video, Tai Hui, Chief Market Strategist Asia Pacific, discusses the latest Chinese bond market and its investment implications.
An enormous market not to be overlooked
Over the past 20 years, China's bond market has grown more than sixtyfold^ and has overtaken Japan as the second largest in the world. The launch of Bond Connect and inclusion in major indices have brought about ample opportunities for China bonds, with foreign ownership still at relatively low levels and set to benefit from the potential inflows.
The Chinese first used bonds in the 19th century*. Today, China's bond market is the second largest in the world.^
The world's top five bond markets (market size in USD trillion)
Different segments of China bonds come with distinct characteristics. Relatively small in size, China's offshore bond markets have seen issuers of higher quality in general, with a forecasted default rate similar to that of Asia and lower than those of Emerging Markets and the US.
Default rates of high yield bonds# across different regions
Potential diversification benefits
Both onshore and offshore China bonds exhibit a lower correlation with global aggregate and developed market bonds when compared with those in Emerging Markets, while offering relatively attractive risk-adjusted returns.
In times of uncertainty, allocating to lowly or negatively correlated assets may help increase sources of diversification.
Relatively low correlation between China and global aggregate bonds
Income potential looking more appealing
Amid rising economic risks, the US Federal Reserve has cut rates aggressively and renewed quantitative easing to help tackle ongoing uncertainties and volatility. In an environment of low or even zero interest rates, it has become more challenging for global investors to find income, making the income potential of China bonds more appealing.
China Bond yields over the past five years
China's bond yield level looks appealing in the USD Asian credit market
Focus on flexibility and quality
Benchmark-agnostic, the Fund invests flexibly across the onshore and offshore CNY-, CNH- and USD-denominated China bond markets. The portfolio may include bonds and debt securities issued by governments and their agencies, financial institutions as well as corporates to capture the diverse opportunities in varying market conditions.
With a focus on quality, the Fund allocates at least 50% of the portfolio in securities that are rated investment grade at the time of purchase.
Active currency management
Within a macro framework, the investment team seeks to achieve competitive total returns by combining top-down strategies and sector views with bottom-up security selection. The portfolio managers may also take active currency positions to maximise returns, offering potential advantages in foreign exchange terms.
Attractive income opportunities
The Fund offers monthly distributing "(mth)" and "(irc)" share classes, providing attractive income opportunities. It is also available in USD, HKD and RMB Hedged classes to help meet investors' need for different currencies. (* Aim at monthly distribution. Dividend rate is not guaranteed. Distributions may be paid from capital. Refer to important information 3)
This article is not issued by J.P. Morgan Asset Management. Available in Chinese only.


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Wednesday, February 29, 2012
Retro Richard Scarry Card [CQC126, SRC #113]
This color challenge inspired my inner 70s child to make another card. How fun!
There's also a fun challenge at Stampin' Royalty to use only paper and ink, no embellishments. Yikes!
This time I targeted an old Richard Scarry book placed in the donation pile because my kids never really got into it (seriously, why not? it's classic!) After I thought about it, all I could see was 100 pages of great illustrations going out the door. So it stayed here. It was a little ... pun alert ... "scary" cutting the pages
but obviously I got over that and cut out a cute image of a crying pig from the "This Little Piggy Went To Market" nursery rhyme.
I thought the story line went along with an "I miss you" sentiment, so I put that under the pig illustration.
Brads for the "i" dots.
Thanks for looking!
Supplies used:
- PTI Block Letter Dies
- Dictionary Page
- Richard Scarry Book
9 comments:
Another adorable card, Kelly! So happy to see you enjoying these colors! They really grabbed me when I saw them!ReplyDelete
What a cute, cute card! Love the pig image and the "I" dots using brads! I know what you mean about cutting up books, but this card may be treasured more than the book would be, so it's all good.ReplyDelete
Squeal!! (sorry couldn't resist!) this is adorable Kelly. Love that you put the piggy on the cute flap and added the creative sentiment underneath!ReplyDelete
Another cute card, Kelly, love your piggy! Thanks again for using the colors this week to create a card for the ColourQ challenge.ReplyDelete
Such a fun card, love it.ReplyDelete
Okay, this is sheer genius!!! TOTALLY gonna have to pick up some old childrens books at a second hand bookstore--can I CASE you?! I LOVE Richard Scarry! :)ReplyDelete
Cute card! Great idea to incorporate the image and use book pages on your die-cut letters! Thanks for joining us at the colourQ this week!ReplyDelete
This is so fun and I just LOVE how you've done the little letters!ReplyDelete
Richard Scarry!!! My inner 70s child is reminiscing right along with yours. I actually am in the process of reading Rhett one of MY old Richard Scarry books.ReplyDelete
I absolutely love reading comments. Thanks so much for stopping by and taking the time to leave one! - Kelly


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Something very exciting is happening this weekend. Two very exciting things actually…
If you can't see from this hurriedly taken photo of my Pride in the Park tickets, I'm headed to Derby for a fantastic and glamorous evening of entertainment and auction as part of Born Free Foundation's 30th anniversary celebrations.
I even dusted off my coloured pencils and did my first piece of art work in two years for the occasion! As a prize donation to the raffle, I created this image of a leopard, based on a photo I took of Born Free's Kuma when I was out in Shamwari – obviously I have a bit of artistic license, and I draw free hand rather than tracing or 'squaring-up', I'm not claiming this leaopard drawing actually looks like Kuma – or is supposed to be him, it was just a great resource for the drawing.
The second exciting part of my weekend – on the theme of art – will be a trip to the opening of Pollyanna Pickering's exhibition as part of the Born Free Foundation Celebration Day on Sunday.
I've been a fan of Pollyanna's work since the days I used to subscribe to a beautiful magazine called Wildscape, specifically exploring and celebrating wildlife art.
It's going to be an awesome 24 hours – can't wait to tell you all about it on the other side!


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It is also completely non-combustible and is fixable to a wide range of roofs no matter the pitch. We have extensive experience working with this material. Greys Artstone produce two products: Reproduction Stone Slates and Reproduction Slates. These mimic the properties their names suggest. Both products conform to or exceed British Standards, which is why we're happy to use them in roof construction.
Artstone is also superior to natural stone in a few key ways. Firstly, it is lighter, weighing approximately 75kgm2. It is also safer to cut and is less prone to breaking. This reduces the material cost and improves roofing efficiency.
Unlike lesser products, Artstone weathers like stone and not concrete. Concrete 'greys' or 'washes' out over time. Artstone does not. It also better resembles stone when cut, which is one of the biggest downsides to concrete. Because of this, we recommend Artstone as a more natural-looking, quality alternative to concrete.
Another benefit to Artstone is its 25-year guarantee. This guarantee covers the product for all manufacturing defects. It is also a guarantee of strength, durability and robustness. This is among the best guarantees in the industry for a material of this type.
The appearance of Artstone is very similar to that of stone or slate, depending on the product you choose. In fact, many people cannot tell the difference. This makes it suitable for roofs on period properties which are Listed. When properly installed, Artstone gives an authentic roofscape and it is designed to diminish, which means the slate lengths reduce up the roof slope for a traditionally authentic appearance.
If you are interested in a stone slate or slate roof for your property, Artstone is a modern material you should consider. We've installed this material on many properties and we are always impressed by the quality and finish of the product.


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What wine goes with cream of asparagus soup?
If you need a wine to pair with cream of asparagus soup or the best wine for Cream of Asparagus Soup, you could try a Sauvignon Blanc to go with it.
Sauvignon Blanc
(SOH-vee-nyawn BLAHNGK): A full white with citrus, melon, tropical & floral notes. Can be smokey.
Another wine pairing for cream of asparagus soup
You may also enjoy these other types of wine with cream of asparagus soup or this Cream of Asparagus Soup wine pairing:
(shar-doh-NAY): A full-bodied white with buttery flavors and vanilla, butterscotch and oak notes.
(shab-BLEE): A dry but oaky French Chardonnay. Lemon, green apple, pineapple with toasted oak.
Check out other types of wine with cream soup
Or, you can browse other ideas for food pairing with Sauvignon Blanc
Food and Wine Pairing
If you'd like find what wine goes with what food, you can use the Hello Vino tool on this page, or view our large list of food and wine pairing suggestions.
Search for a Wine Pairing:
For example, search wine with turkey or gouda wine pairing.


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There are two ways to find your ideal vacation rental:
Power Search --The most popular and efficient way to find
a vacation rental, the
Power Search enables you to indicate your preferences, including
your vacation time frame, number of bedrooms, maximum price, proximity to beach,
and key amenities. Select a specific location, an entire region, or even a combination
of towns. The search results will be presented in a list of suitable properties
according to price. They will also be presented as pins on a map for you to view
each property relative to area beaches, town centers, or other points of interest.
Once you have performed your search, you can use
MyVacations to save both your requirements and the results, and
then share them with family and friends.
Browse all rentals
-- You can also view a directory of all of the rentals in a specific
Cape Cod, Martha's Vineyard,
or Nantucket town listed by occupancy,
high to low.
Calendar – Prior to inquiring about a property, be sure to view
the listing's pricing and availability calendar.
Owner Specials -- Many homeowners post an Owner Special
with a special offer or discount.
Last-Minute Availability Alert – The
indicates that the rental has at least one week available within the next month.
Alerts are usually accompanied by an Owner Special offering a special offer or discount.
Videos -- Some of the listings offer a video. If so, it is right
below the pictures.
When you find a rental you are interested in, you can phone or email the contact
person for that rental. If you send an email inquiry, the form you
complete will be sent to the contact person. In a given session, you need to input
your information only once, and you can then send emails to the listers of as many
properties as you wish. You will be able to enter a general comment about the composition
of your party, etc. that will go to all listers, and you will also be able to send
a unique message to individual listers if you have specific questions about just
their property.
MyVacations is a feature that enables
you to save your ideal rental search criteria and the results so that, when you
return in the future, you can rerun your search and add to your existing list of
favorites. A shopping cart for vacations! In addition, you can take online notes
about the rentals and even rate them. Then, you can share your list with family
and friends, and they, too, can record notes and rate the listings.
In order to use MyVacations, you must provide your email address and an
optional password to register. You can do this either before or after performing
the Power Search. Once registered, when you return to WeNeedaVacation.com,
you will choose the MyVacations link on the home page. Log in, and you
can either review previously set up "vacations" or start a new one by performing
a Power Search.
To find a listing by its property ID, look for "Find by Property ID" field in the
upper right corner of any page on the site.
Our MyVacations Long-Term Rentals Directory
lists, by town, the rentals available for one month or longer during the off season.
Length of Stay
Summer rentals usually require a minimum stay of one week and generally run from
Saturday to Saturday. Some rentals begin on another day of the week, however, especially
on Martha's Vineyard and Nantucket. Off-season stays or smaller homes or apartments
are generally more flexible, with many homes available to rent on a daily basis
or for long weekends.
Check-in/Check-out Time
Check-in time is most often early to mid-afternoon with check-out time in the mid-
to late morning.
Security Deposit
Most homeowners and realtors require a refundable security deposit for a rental
home. Check with the homeowner or realtor for details. The security deposit is usually
due to be returned within a month after tenancy.
It is in your best interest, as well as that of the homeowner, to have a signed
lease that spells out the details of your tenancy, including information about the
security deposit, schedule for payment, and the cancellation policy. Many homeowners
and listing agents require at least half of the rent due at the time of lease signing,
with the remainder of the rent due one to three months prior to tenancy.
In Season, Shoulder Season, and Off Season
"In season" generally refers to all the weeks in July and August, the "shoulder
season" generally includes the months of May, June, September, and October, and
the off season runs from November through April. Most homeowners offer different
prices for in season, shoulder season, and off-season. Check the listing's calendar
or with the homeowner or listing agent for details.
Book Early
Because of the tremendous popularity of the Cape and Islands as a vacation destination,
we encourage you to begin your search early for a rental property. Many rental homes
are often booked for the summer by the end of February. This is particularly true
with waterfront, water view properties. And plan ahead if you need to accommodate
a greater number of guests, as larger homes tend to book early.
Visitors to Martha's Vineyard and Nantucket in particular are advised
to make precise rental and travel plans well in advance. If you intend to take a
car to the Islands, make ferry reservations early in the year through
the Steamship Authority
Authority at 508-771-4000. For Island ferry info.
Most short-term rentals include all utility costs.
Household Supplies
Unless otherwise noted, most rental homes supply kitchen utensils, dishes, and some
cleaning supplies. You are expected to supply your own linens and towels unless
the listing specifies that the owner will supply them via "linens included" in the
amenities section. There are linen rental companies, several of which will even
deliver the linens.
Prior to Your Vacation
Before you leave for your vacation home, be sure you have precise directions; a
key (or arrangements for picking up the key) to the home; and the phone number of
the homeowner, listing agent, or property manager.
Upon your arrival
If anything is amiss at the home when you arrive, contact the owners or their agent
immediately. Being informed of any issues only after your departure is of no benefit
to either you or the homeowner.
Homeowners Are Responsible for Their Own Listings
All of the information found on the individual property pages has been provided
by the property owner or listing agent. WeNeedaVacation.com is not responsible for
the accuracy of the content provided. If, however, you notice a discrepancy, please
notify us so that we can investigate and require that the lister rectify the situation.
Use the Power Search to find
vacation rentals that will allow pets. Dogs are more likely to be accepted than
cats unless the cats are declawed. In some cases, you will be required to pay an
additional pet deposit.
Be sure to treat your pet with a flea and tick preventive at least a week prior
to your vacation.
Rental owners appreciate pet parents who offer to bring sheets to cover upholstered
Always keep your dog on a leash (or under voice control if at an off-leash facility)
and always clean up after him, both at the rental property and elsewhere.
Keep in mind that the majority of beaches do not allow dogs in season. Learn about
dog-friendly beaches and great
locations to walk your dogs.
The Transportation section of our
Vacation Planner provides extensive information about traveling to and within
all Cape Cod and Islands regions.
Guest Reviews are an effective means of building credibility, confidence, and trust
in our listings and are invaluable to homeowners and future vacationers alike. If
you would like to write a review about your experience in a vacation rental, go
to the listing and click on the "Write a review" link. Provided the guest review
meets our Guidelines,
a copy is sent to the homeowner, who may submit a response if they choose, and the
review will be posted, generally within 7 business days.
In the unlikely event that your experience at one of our properties is unduly negative,
please email at email@example.com us with the details. We will follow up with you and the homeowner.
You can feel comfortable and confident when booking your vacation home through WeNeedaVacation.com
Feel free to call (888-281-8660) or email us at firstname.lastname@example.com anytime.
If you have any feedback or suggestions on how we can make our website easier for
you to use, please let us know.


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Westerly Winds!!!
Western Flyer v Westerly Winds!!! The weather gods will always win … So with the weather outlook over the next few days looking ominous might I suggest any interested parties either email me and leave their names and contact numbers or contact me on 07736678506 for updated reports!


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Bed and breakfast accommodation in Clynnogfawr, at the gateway to the Llŷn Peninsula and Snowdonia. The perfect base to explore and relax. Located on the Wales Coast Path, 700m from the sea, with stunning sunsets.Read More
Clean and comfy
Seven rooms, twins, doubles and triples, with a choice of sea or mountain views.Read More
Fully Licensed
A friendly and relaxed atmosphere to may your stay an enjoyable and memorable one.Read More
In order that we can make your stay the best possible, get in touch if you need any information about us or the area in general. We try our best to get back to guests as soon as we can.
Christmas Menu
A 5 course feast – £22.50
We're confident that we have a delicious menu that will intice you to come and celebrate Christmas with us this year, be that an afternoon or evening meal.
We can accommodate up to 4o diners and welcome groups, couples as well as individuals.
Click below for a printable PDF copy of our menu:
To secure a date for your lunch we kindly ask for a £5 deposit and confirmation of your choice of food and the number of diners in your party. At the end of your meal we will give you one large bill for the remaining amount.
Please get in touch if you require any further information about what we have to offer.Read More
A stone's throw from the sea
Bryn Eisteddfod is located a short walk from the beach where seals bathe, cormorants fish and the sun sets magnificently.Read More
Within easy reach of Snowdonia
Awe inspring countryside with magnificent views – a short drive away. Snowdonia is world renowned for its incredible beauty all year round.Read More
At the Gateway to the Llŷn Peninsula
Bryn Eisteddfod is the ideal place to explore the stunning landscape and coastline of the Llŷn Peninsula. Magnficent coves and laid back roads. Home to Tŷ Coch, Porthdinllaen, voted the third best beach bar in the world.Read More
Views of Caernarfon Bay
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Leave Tomorrow – My Ride to the Bottom of the World is here!
(Click here to purchase on Amazon)
This book details my journey from Austin, Texas to the tip of South America.
Here's the back cover copy:
After building a successful business, Dirk Weisiger was ready for something new. But he wasn't sure what. Maybe a motorcycle adventure, I've never done that!
What followed was a fourteen-month, solo motorcycle journey from Austin, Texas to Ushuaia, Argentina, filled with unexpected adventures, surprises, and lessons about life and travel.
"I headed south to see new vistas on a solo journey, but ended up feeling more connected to the people I met along the way."
In this book, you'll not only enjoy Dirk's adventure and insights, but find inspiration for your own journey. Dirk Weisiger is a travel trekker, trick roper, and storyteller. Dirk has always enjoyed speaking to groups, spinning tales, ropes, and offering lessons he's learned in adventures of life and business.
He's travelled to five continents and climbed Mount Kilimanjaro. Most of all Dirk loves people and believes that making new friends is the best part of travel.
(A portion of proceeds from this book help sponsor children at the Colegio Bautista El Calvario private school in Managua, Nicaragua.)
"For everyone thinking of a new adventure, a new life, or even a new venture: DO IT." – Jim Rogers, bestselling author of Investment Biker.
"This isn't the first book I've read on riding to Ushuaia, but it is probably the most enjoyable." – Muriel Farrington, Ambassador, BMW Motorcycles Of America
If you've enjoyed my travel blogs, I hope you'll pick up a copy, and grab a few as gifts for friends!
(Click here to purchase on Amazon – print or Kindle)