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Unlawful Flight to Avoid Prosecution - Criminal Attempt to Commit Homicide
|Age Progressed Photograph - 2014
Scars and Marks:
Deemer plays multiple musical instruments, including the accordion. He is known to frequent auto shows and gun shows, as well as flea markets. He may travel to Carlyle, Pennsylvania, and Covington, Kentucky to attend these shows.
Deemer may be traveling with his girlfriend, Sally Ann Suttle. She is described as a White female with a Date of Birth of October 29, 1956. She may work as a nurse and has previously lived in Hawaii. She is not a fugitive from the law.
Barry James Deemer is wanted for his alleged attempt to solicit an individual to assist in the murder of his ex-girlfriend in Westmoreland County, Pennsylvania, in late October of 1995. Deemer allegedly supplied an individual with an unregistered, semi-automatic pistol and ammunition to be used in the murder of the woman.
Deemer was charged via a criminal complaint in the Commonwealth of Pennsylvania in Westmoreland County on October 24, 1995, for criminal solicitation to commit murder, violation of the Uniform Firearms Act - possession of a firearm without a license, violation of the Uniform Firearms Act - lending of a firearm without a license, and violation of the Uniform Firearms Act - sale or transfer of a firearm to an unlicensed person. Deemer was arrested and released after posting bond. On November 8, 1996, a bench warrant was issued for Deemer for failure to appear after he did not appear for pretrial motions. On February 4, 1997, another bench warrant was issued for Deemer for failure to appear after he did not appear for a status conference. Finally, on February 21, 1997, a criminal complaint and federal arrest warrant were issued for Deemer in the Western District of Pennsylvania, Pittsburgh, Pennsylvania, for moving and traveling in interstate commerce with the intent to avoid prosecution for the crime of criminal attempt to commit homicide.
If you have any information concerning this person, please contact your local FBI office or the nearest American Embassy or Consulate.
Field Office: Pittsburgh


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WHEELING - For more than a decade, the Wheeling Heritage Port Sternwheel Festival has offered Ohio Valley residents three days of fun, food and boats on the Ohio River to enjoy each September.
And while the entertainment is free to attendees, organizer James Arritt said it costs about $100,000 a year to put on the event. That includes paying for entertainers, along with the cost of electricity, water and garbage service from the city of Wheeling. Though the festival continues to be a big hit with the public, Arritt said more donations are needed to help keep the event going. Last year the festival, though successful, actually lost money.
"People don't realize it, but we spend $25,000 just on entertainment," Arritt said.
Article Photos
A sternwheeler makes it way to Wheeling Heritage Port on the Ohio River.
File Photo by Scott McCloskey
Individuals or companies interested in helping to sponsor the festival can call Arritt at 740-695-3667 or email him at firstname.lastname@example.com.
This year's Sternwheel Festival is set for Sept. 12-14 at Heritage Port on Water Street in downtown Wheeling. The festival is expected to host nine to 12 sternwheeler boats at the port. About 42 vendors will line Water Street, offering a variety of dishes for people to purchase. Entertainment will include various local and regional musical acts and dance school performances. There will also be entertainment for children such as inflatables.
A fireworks display by Zambelli is slated for about 9:15 p.m. Saturday. The ABATE motorcycle club is expected to perform trick rides at 2 p.m. Saturday. And a classic car show is slated for Friday evening.
The festival was founded in 2002 and is sanctioned by the American Sternwheel Association.

subset: commoncrawl


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National Institute of Mental Health; Department of Veterans AffairsCognitive Training in Alzheimer's Disease: A Meta-Analysis of the LiteratureSitzer, D. I., Twamley, E. W., et al.
Acta Psychiatr Scand, 114(2), 75-90.
Indicators of Review Quality:
Description: This is a meta-analysis of controlled trials that examined the effects of cognitive training, including restorative and compensatory treatments, to improve the cognitive performance of individuals with Alzheimer's disease.
Question(s) Addressed:
Question not specifically stated.
Population: Alzheimer's disease patients or patients with probable Alzheimer's disease.
Intervention/Assessment: Cognitive training (including a comparison of restorative and compensatory strategies)
Number of Studies Included: 17
Years Included: 1840 to 2004
Compensatory Treatments - "Compensatory techniques (e.g. visualization, procedural memory training, and external devices) appeared to be less effective than restorative strategies at improving cognitive and functional abilities" (p. 87).
Restorative Treatments
The results from 19 controlled trials suggest that cognitive training can improve cognitive and functional abilities. A wide range of effect sizes from small 0.2 to large >0.8 were reported.
Cognitive training appears to have the greatest effect on the outcome of performance-based ADLs.
Limited follow-up data suggest that effects of cognitive training may be maintained for an average of 4.5 months post treatment. (pages 86-87).
"The most efficacious CT interventions were those that used restorative strategies, such as general cognitive stimulation (e.g. prompting recall of remote memories, practicing conversation skills, problem solving, reading, and engaging in creative activities), computerized visuospatial drills, and memory drills emphasizing repetition" (p. 87).
"Compensatory techniques (e.g. visualization, procedural memory training, and external devices) appeared to be less effective than restorative strategies at improving cognitive and functional abilities" (p. 87).
Service Delivery
Individual cognitive training sessions appear to be more effective than group sessions.
Keywords: Alzheimer's Disease, Cognition
Access the Review
Added to Compendium: December 2011
The American Speech-Language-Hearing Association (ASHA) is the national professional, scientific, and credentialing association for 186,000 members and affiliates who are audiologists; speech-language pathologists; speech, language, and hearing scientists; audiology and speech-language pathology support personnel; and students.
The ASHA Action Center welcomes questions and requests for information from members and non-members.
Available 8:30 a.m.–5:00 p.m. ET Monday–Friday
Site Help | A–Z Topic Index | Privacy Statement | Terms of Use
© 1997-2016 American Speech-Language-Hearing Association


text:
Documents & Reports, previously known as World Development Sources (WDS) contains more than 145,000 publically available World Bank documents that enable sharing the institution's extensive knowledge base and implementing its access to information policy. It includes operational documents (project documents, analytical and advisory work, and evaluations), formal and informal research papers, and most Bank publications in more than 60 languages.
Cross sectional
World, East Asia & Pacific, Europe & Central Asia, Latin America & Caribbean, Middle East & North Africa, South Asia, Sub Saharan Africa, High income, Low or Middle income, IBRD, IDA
Agriculture & Rural Development, Aid Effectiveness, Climate Change, Economy & Growth, Education, Energy & Mining, Environment, External Debt, Financial Sector, Gender, Health, Infrastructure, Labor & Social Protection, Poverty, Private Sector, Public Sector, Science & Technology, Social Development, Trade, Urban Development
API, Query tool
Projects related data from SAP, other data from IW
1946 - Current


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May 24, 2016
Monticello, FL - Jefferson County has lived by the theme 'Uncommon' for the past two years. It appears that stands particularly true this year as the Tigers enter the State Semifinal game with five regular season losses.
Head Coach Jeremy Brown, though, sees that as perfectly normal.
"That was part of our uncommon theme, going outside of the norm and playing Madison and Godby and some of those schools," Brown said. "Our kids responded the way we thought they would. We didn't win the games but you go back and watch those films and we got better."
If you scan the Tigers schedule, all five of their losses came against schools that are larger in size - Godby, Wakulla, Madison, Taylor County and North Florida Christian.
"The confidence that it gave us to know that 'hey, they may be a bigger school, but we can play with 'em,'" said Levi Cobb, a senior linebacker.
"If you can go toe-to-toe with Madison for a half, then you feel like you can play with anybody," Brown said.
Through the first two playoff games, Jefferson County has won by an average of 38 points.
But an undefeated Union County team now stands in their way. However, the Tigers have homefield advantage.
"We're glad to be at home," said Alphonso Footman, a senior runningback. "It's in our environment. We're comfortable. We just gotta win the game."
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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Lighthouse Deaf Baptist Church is a place for the Deaf, Deaf/Blind, Hard of Hearing, hearing, and anyone else looking for a church to worship the Lord with us. Our services are preached in American Sign Language and voiced either by our Pastor as he preaches or by a voice interpreter. If you are looking for the answers to life's questions, God has them for you in His Word in which it will guide and encourage you as you seek Him for those answers. It is our hope and prayers that the services at Lighthouse Deaf Baptist Church will be a blessing to you and we meet you soon.
When are the services?
On Sunday, we meet at 1:30 PM for Sunday School, then following our Sunday School, starting at 2:40 PM, we have our church services. We meet in the afternoon since the hearing church the building which allows us full use of building. Then on Wednesdays, our mid week Prayer/Bible Study This service begins at 7:15PM with singing and praising God, then our Bible Study at 7:30PM. We meet in the same building now. For more information, click here to go to the Bible Study page.
I'm not Deaf, may I still attend?
Yes, of course. You are more than welcome to attend the services. Our church is not a "closed" church to the hearing. Our congregation is primarily Deaf, Hard of Hearing, and Hearing who know sign language. The services are preached in American Sign Language (ASL), yet voiced by our Pastor or a voice interpreter. You do not need to know ASL to attend the Lighthouse. We look forward to meeting you soon.
What can I wear to church?
Our goal is not to debate or argue about a dress code or what you wear or don't wear. Our Pastor and staff dress professionally for they want to honor the Lord in their service, yet, we have never turned away a visitor or member because of their attire. We want you to feel comfortable in our services. Come as you are.
I have children. Can they attend too?
Your children, Deaf, Hard of Hearing, or hearing are always welcomed. We have a nursery for the babies, a children's class for the older kids, and of course, adult classes for you. Our nursery is staffed with only qualified, Pastor approved workers. No child is left alone to take care of themselves. You can feel safe with your child in our hands.
I have other questions, who can I ask?
That we believe is the most important question because we know that we cannot answer everything here on our website, but we know that our Pastor and or staff would be willing to answer any questions or concerns you may have. If you feel that you need to talk with the Pastor privately, he is willing to take the time and talk with you, or set up an appointment to talk with you. You are the reason we are here, to share the love of God and the Gospel with you so that the Deaf may see the Gospel.


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Special Advisor for Children's Issues, Ambassador Susan Jacobs, will be traveling to the Philippines and Hong Kong, April 22–24.
While in the Philippines, Special Advisor Jacobs will participate in an Adoptions Workshop with Department and U.S. Citizenship and Immigration Services staff from embassies and offices throughout the East Asia and Pacific region. She will also meet with Philippine government officials to discuss international children's issues.
In Hong Kong, the Special Advisor will visit the newly opened Asia Pacific Regional Office of the Hague Conference on Private International Law. She will also meet with government officials to discuss cooperative measures to encourage more countries in the region to join and successfully implement the Hague Abduction and Adoption Conventions.
For more information about children's issues, please visit: ChildrensIssues.state.gov
For updates on Special Advisor Jacobs' trip, follow her on Twitter: @ChildrensIssues
For press inquiries please contact firstname.lastname@example.com or (202) 647-1488.


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Click on a thumbnail to go to Google Books.
Interracial Intimacies: Sex, Marriage, Identity, and Adoption
by Randall Kennedy
No current Talk conversations about this book.
This is a pretty deep book. You will find lots of stuff that will never hit our history books. It is a good history book on race and relations in America. I wasn't crazy about the chapters on adoption as the author does not believe that there should be race matching in adoption - and I do. My personal opinion runs that if all things are equal and a child of color is wanted by a white couple or a couple of the same race, the child should be raised by the couple of the same race for reasons to involved to state here. The author - a person of color - disagrees and gives all his reasons - which are good reasons. If anyone else reads this I'd love to discuss the book with you
Kennedy examines the complex ways in which race defines relations between blacks and whites in the US.
References to this work on external resources.
Wikipedia in English (2)
Amazon.com Product Description (ISBN 0375702644, Paperback)In Interracial Intimacies, Randall Kennedy hits a nerve at the center of American society: race relations and our most intimate ties to each other. Writing with the same piercing intelligence he brought to his national bestseller Nigger: The Strange Career of a Troublesome Word, Kennedy here challenges us to examine how prejudices and biases still fuel fears and inform our sexual, marital, and family choices.
Analyzing the tremendous changes in the history of America's racial dynamics, Kennedy takes us from the injustices of the slave era up to present-day battles over race matching adoption policies, which seek to pair children with adults of the same race. He tackles such subjects as the presence of sex in racial politics, the historic role of legal institutions in policing racial boundaries, and the real and imagined pleasures that have attended interracial intimacy. A bracing, much-needed look at the way we have lived in the past, Interracial Intimacies is also a hopeful book, offering a potent vision of our future as a multiracial democracy.
(retrieved from Amazon Thu, 12 Mar 2015 18:10:06 -0400)
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slightlysideways - I think it goes without saying that a team principal on their own isn't going to make a team successful. But with the resources he has to work with, he's pulled together a fantastic team and, after a more humble start, lead them to great successes. Sure, without the team he wouldn't necessarily have achieved it... but that's part of what he has achieved. And on the other hand, a fantastic group of individuals isn't necessarily going to go anywhere if the man in charge of pulling them all together is rubbish at his job. It isn't down to any one person (even Newey), but Horner has certainly played his part well.


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Honey Brook Borough's streets and sidewalks are undergoing a makeover.
Street Scapes Phase 1 will replace curb and sidewalks and repave the entire road from the intersection of routes 10 and 322 going east on Horseshoe Pike to Maple Street about 900 feet.
"The project is a beautification of the area. The curb and sidewalk was in need of repair desperately," said Honey Brook Borough Engineer Chris Falencki who designed the project on behalf of the borough. "The idea is that if the street is improved the home owners, businesses and residents would also improve their properties."
The south side of Horseshoe Pike was complete before Mother's Day Weekend.
"I've already seen an improvement on at least four different homes over the weekend. It's encouraging. All we did was throw dirt and grass seed down, but they put the plants in themselves. They did a nice job."
"The other concept is that this is the center part of the town, the business district of the town, and we're hoping to encourage more businesses to relocate and open businesses in the downtown area," said Falencki.
Street Scapes Phase 1 is funded by a more than $900,000 grant from the Chester County Department of Community Development with the borough funding 5 percent. The grant includes sidewalks, curbs, street lights and storm water improvements, replacing catch basins and inlets. Then, the borough will mill out the entire road and put in new crosswalks.
Brick facade walkways are being installed within the sidewalks and crosswalks.
"The intention was to match the feel of the buildings in the area so that it wouldn't be something odd looking," he said.
Because brick has a tendency to lift and fall due to temperature changes, Honey Brook Borough Council decided to go with brick colored concrete stamped with a brick motif, said Falencki.
Period style lighting will be installed by PPL at a cost of about $5,000 a light, all funded by the grant, he said.
"The idea is a lamp that looks like a gas lamp but it's actually an electric lamp. It gives the feel of being back in the 1800s."
There will be 17 street lamps on one side and 18 on the other side. Lamp posts are about 10 to 15 feet high and will be spaced about 50 feet apart, said Falencki.
"It's going to be more on the pedestrian level, lighting the sidewalk and the facades, keeping the light down instead of lighting up the entire street and all the buildings," he said.
Existing street lamps on 75-foot poles will be taken down in time.
"That will be determined by how much lighting the borough wants on the street. The concept is to remove those lights and bring the light closer to the street."
"It will give a more safe walking area without having to light up the entire street," said Falencki,
He said the ornate lights will enhance the area and match the Wayne Brook Inn lights. The thrift store is also installing similar lights, he said.
"That's the incentive, to get the property owners to start improving their properties at the same time, which they are doing so."
Light installations should be complete by the first week of June. Street Scape Phase 1 is anticipated to be complete by July. Falencki recognized Verizon, PPL and Service Electric for their cooperation during the project.
The borough is applying to the county to fund Phase 2, which will be at the intersection of routes 322 and 10 heading west about 200 feet or depending on how much funding they receive.


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Commentary by Jeff Commings
PHOENIX, Arizona, September 4. FORTY years ago today, Mark Spitz got his seventh gold medal draped around his neck at the 1972 Olympics. I wasn't alive when this happened, but the impact of that performance permeated nearly my entire swimming life from the moment I first jumped into a swimming pool at age 4.
Spitz's feats in Munich are like a ghost story coaches tell their swimmers, only with a happy ending. I watched the Olympics in 1984 and was in awe of people like Tracy Caulkins, Rowdy Gaines and Michael Gross. My coach said they would all go down in history as some of the best the sport has ever seen, and added: "But they'll never be as good as Mark Spitz." And then he proceeded to tell me about those eight days in Munich.
And so, every Olympics after that, Spitz's performances were the bar which every athlete had to reach. Matt Biondi tried it in 1988, coming up short of the perfect Olympics, but still winning seven medals. And then there was Michael Phelps, coming a few steps short of the top of the mountain in 2004, then climbing to the top and on to another stratosphere in 2008.
Spitz's first race in Munich was the 200 butterfly on August 28, and there was no way he was losing this race. His rivals were teammates Gary Hall, who held the world record in 1970 before Spitz took it back in 1971, and Gary Backhaus. Hall and Backhaus fought hard, but a gold medal was not in the cards for them at this meet. Spitz's time of 2:00.70 lasted as the world record for four years.
Unlike Phelps' run in 2008, Spitz was pretty much assured of gold in the three relay events, and so he had no problem winning gold number two in the 400 free relay with David Edgar, John Murphy and Jerry Heidenreich in 3:26.42. Spitz swam his leg on the relay about an hour after completing the 200 fly race.
Spitz only had one race on August 29. The 200 freestyle had long been one of his best events, and he showed why with a big win over teammate Steve Genter in 1:52.78.
With only heats and semifinals of the 100 butterfly on August 30, Spitz was fresh and full of fire on August 31 for another double-duty day. First up was the 100 butterfly final, in which he was able to improve on the silver-medal performance from the 1968 Olympics with a world record swim of 54.27. Not long after, he helped the United States to gold in the 800 free relay (7:35.78) with John Kinsella, Fred Tyler and Genter.
The way Spitz won his last two gold medals is what makes his accomplishment a little bit easier than Phelps' feat. With two days between championship finals races, Spitz had plenty of time to relax, re-focus and mentally prepare for what he believed would be his most challenging individual event: the 100 freestyle. (Phelps only had one day in 2008 when he didn't swim in a championship final.) Spitz performed well in the heats and semifinals, but expressed doubts about winning to ABC commentator Donna de Varona before the race. Though Phelps never publicly expressed doubt before stepping up to the final of the 100 butterfly, the scenarios are similar. Like Spitz, Phelps' last individual race would be his toughest, and like Spitz, the race was not decided until the final stroke. Spitz won gold medal number six in world record time (51.22), but only by four tenths of a second over teammate Jerry Heidenreich. Phelps' margin of victory in the 100 butterfly was considerably smaller. Only one hundredth of a second separated him from Milorad Cavic to become one of the unforgettable races in Beijing.
Spitz and Phelps both closed out their historic runs in the 400 medley relay. While practically everyone appreciated the moment at the time, very few knew how quickly and powerfully Mark Spitz would transcend the sport. While not an official world in the Webster's dictionary, "Spitzian" became a word thrown around every four years. ("Phelpsian" sort of made a run at becoming part of the lexicon, and enjoyed a little more than its 15 minutes of fame.)
Watch all of Spitz's seven gold medal races:
Though Spitz's accomplishments are now rated second-best in the Olympic annals, what he did in those eight days should never be forgotten, much like we should never forget how close Biondi got in 1988 or that Phelps gave it a try in 2004.
Contact Jeff Commings at firstname.lastname@example.com.


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Janko Tipsarevic defeats Lleyton Hewitt in Australian Open 2013 Round One
Janko Tipsarevic defeated Lleyton Hewitt in Round One of the Australian Open 2013 Tennis Championships. Hewitt was a hometown favorite over in Australia.
The final scoreboard: Men's Singles – 7-6 (Set 1), 7-5 (Set 2), 6-3 (Set 3).
The details:
Congrats Janko!
Via News.com.au:
Lleyton Hewitt's heart proved no match for Janko Tipsarevic's heat as the Aussie warrior bowed out of the Australian Open at the first hurdle on Monday night.
Hewitt fell to the white-hot No.8 seed 7-6 (7-4) 7-5 6-3 – Tipsarevic producing some amazing tennis from the middle of the second set to sink the 31-year-old Australian on Rod Laver Arena.
In his record 17th successive Australian Open, Hewitt's defeat means he has only ever once got beyond the fourth round at Melbourne Park – when he made and lost the final in 2005.


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Drug Metabolism and Pharmacokinetics
Young-Jin CHUN
Released: December 25, 2014
Claudio ZAMPERINI, Elena DREASSI, Giulia VIGNAROLI, Marco RADI, Stefania DRAGONI, Silvia SCHENONE, Francesca MUSUMECI, Massimo VALOTI, Riccarda ANTIOCHIA, Maurizio BOTTA
[Advance Publication] Released: May 20, 2014
The aim of this study is to investigate the metabolic (cytochrome P450-dependent) behaviour of pyrazolo[3,4-d]pyrimidines 1–10 dual Abl/Src kinase inhibitors. All the compounds demonstrate good metabolic stability both in human liver (HLM) and in rat liver (RLM) microsomes. Moreover, all the tested molecules undergo the same metabolic CYP-dependent reactions, namely oxidative dechlorination and N-dealkylation. These metabolic pathways are fully characterized for compound 1. In HLM, the dehalogenated metabolite accounts for about 87% of the full 1 metabolism, while the N-dealkylated metabolite accounts for 12%. Inhibition studies performed using different CYP-inhibitors indicate that the 3A family is the isoenzyme family most involved in pyrazolo[3,4-d]pyrimidine metabolism. This observation is confirmed by studies performed by using CYP3A selective substrates. Furthermore kinetic analysis performed in RLM, HLM and cDNA CYP3A4 shows that the affinity of CYPs towards compound 1 is similar in all the tested preparations (Km = 32.7, 21.8, and 48.7 µM, respectively).
Poe-Hirr HSYU, Diane R. MOULD, Richat ABBAS, Michael AMANTEA
[Advance Publication] Released: June 10, 2014
Bosutinib is an orally active, competitive inhibitor of Src/Abl tyrosine kinases. A population pharmacokinetic model was developed using data pooled from 3 studies of patients (n = 870) with solid tumors or Philadelphia chromosome–positive leukemia. Patients (aged 18–91 y, weighing 35–221 kg) who received bosutinib 50 to 600 mg orally with food each contributed 6–9 pharmacokinetic samples. The final pharmacokinetic model was a linear two-compartment model with first-order absorption, an absorption lag-time, and dose-dependent bioavailability. Oral absorption was relatively slow, with a half-time of 1.14 h and a lag-time of 0.87 h; time to peak concentration was 5–6 h. Apparent clearance was 120 L/h. The apparent volume of the peripheral compartment was large with a slow turnover; alpha and beta half-lives were 19 h and 290 days, respectively. All parameters were estimated with acceptable precision (standard error <30%). No tested covariate (protocol, baseline demographic/clinical characteristics, or laboratory results) explained the high inter-individual variability of bosutinib pharmacokinetics. Therefore, adjusting bosutinib dose for body size (weight, surface area) would not provide benefit over fixed dosing. Using this exposure model in pharmacodynamic assessment of one study, adverse event incidence was shown to be similar in overall and bosutinib-responsive populations.
Maiko ABUMIYA, Naoto TAKAHASHI, Takenori NIIOKA, Yoshihiro KAMEOKA, Naohito FUJISHIMA, Hiroyuki TAGAWA, Kenichi SAWADA, Masatomo MIURA
[Advance Publication] Released: June 03, 2014
Nilotinib potently inhibits human uridine diphosphate-glucuronosyltransferase (UGT1A1) activity, causing hyperbilirubinemia. We investigated the influence of UGT1A1 polymorphisms and nilotinib plasma trough concentrations (C0) on nilotinib-induced hyperbilirubinemia in 34 Japanese patients with chronic myeloid leukemia (CML). The proportion of patients with hyperbilirubinemia was significantly higher among patients with the UGT1A1*6/*6 and *6/*28 genotypes (poor metabolizers) than among those with other genotypes (p = 0.004). The median time to elevation of bilirubin levels in UGT1A1 poor metabolizers was 2.0 weeks (hazard ratio, 6.11). The median time to reduction in nilotinib dose in UGT1A1 poor metabolizers was 4.0 weeks (hazard ratio, 7.52; p = 0.002). Consequently, in the maintenance phase 3 months following the initiation of nilotinib therapy, the median daily dose and C0 of nilotinib were 350 mg/day and 372 ng/mL, respectively, in UGT1A1 poor metabolizers, and 600 mg/day and 804 ng/mL, respectively, in the other patients. Patients at increased hyperbilirubinemia risk could be identified by prospective UGT1A1 genotyping prior to nilotinib therapy. To avoid an interruption of CML treatment due to nilotinib-induced hyperbilirubinemia, it may be beneficial to reduce the initial nilotinib dose to 300–400 mg/day for UGT1A1 poor metabolizers.
Yoshiaki KITAMURA, Kenta YOSHIDA, Makiko KUSAMA, Yuichi SUGIYAMA
[Advance Publication] Released: July 08, 2014
A pharmacokinetic/pharmacodynamic (PK/PD) analysis is important in antibiotic chemotherapy. Basically, the in vivo efficacy of antibiotics that exert concentration-dependent effects can be predicted using conventional PK/PD indices such as the ratio of the area under the curve to the minimum inhibitory concentration (AUC/MIC) and/or the ratio of the maximum plasma concentration to MIC (Cmax/MIC), whereas that of antibiotics with time-dependent effects can be determined using the period of time for which the drug concentration exceeds the MIC (time above MIC [TAM]). However, an optimal PK/PD index remains to be established for some antibiotics. Thus, a PK/PD model which describes the PK profile and effect of an antibiotic was developed, and the results obtained from this model were interpreted to form a PK/PD index map to assess the optimal PK/PD index for the antibiotic. The findings from the map were generally consistent with clinical outcomes even for the antibiotics which proved to be exceptions to the conventional classification. For example, AUC/MIC was an optimal index for azithromycin despite its time-dependent bactericidal activity, and Cmax/MIC was a poor index for arbekacin despite its concentration-dependent profile. Thus, the map would be useful for selecting the appropriate PK/PD index for an antibiotic.
Mitsutoshi ASAKURA, Masataka NAKANO, Kohei HAYASHIDA, Hideaki FUJII, Miki NAKAJIMA, Koichiro ATSUDA, Tomoo ITOH, Ryoichi FUJIWARA
Nitrilase, which is found in plants and many types of bacteria, is known as the enzyme that catalyzes hydrolysis of a wide variety of nitrile compounds. While human nitrilase-like protein (NIT), which is a member of the nitrilase superfamily, has two distinct isozymes, NIT1 and NIT2, their function has not been well understood. In this study, we investigated whether human NIT1 and NIT2 are involved in the hydrolysis of drugs using vildagliptin as a substrate. We performed Western blot analysis using human liver samples to examine protein expression of human NIT in the liver, finding that human NIT1 and NIT2 were highly expressed in the liver cytosol. We established stable single expression systems of human NIT1 and NIT2 in HEK293 cells to clarify the contribution of human NIT to hydrolysis of vildagliptin. Although the formation of a carboxylic acid metabolite of vildagliptin (M20.7) was observed in human liver samples, M20.7 was not formed by incubating vildagliptin with HEK293 cells expressing human NIT1 or NIT2. This suggests that human NIT1 or NIT2 is not involved in the metabolism of vildagliptin. Further investigation using other drugs is needed to clarify the contribution of human NIT to drug metabolism.
Hiroshi ARAKAWA, Sachi SAITO, Masahiko KANAGAWA, Hiroki KAMIOKA, Kentaro YANO, Kaori MORIMOTO, Takuo OGIHARA
l-Phenylalanyl-Ψ[CS-N]-l-alanine (Phe-Ψ-Ala), a thiourea dipeptide, was evaluated as a probe for peptide transporter 1 (PEPT1). Uptake of Phe-Ψ-Ala in PEPT1-overexpressing HeLa cells was significantly higher than that in vector-transfected HeLa cells and the Km value was 275 ± 32 µM. The uptake was pH-dependent, being highest at pH 6.0, and was significantly decreased in the presence of PEPT1 inhibitors [glycylsarcosine (Gly-Sar), cephalexin, valaciclovir, glycylglycine, and glycylproline]. In metabolism assay using rat intestinal mucosa, rat hepatic microsomes, and human hepatocytes, the amount of Phe-Ψ-Ala was unchanged, whereas phenylalanylalanine was extensively decomposed. The clearance, distribution volume, and half-life of intravenously administered Phe-Ψ-Ala in rats were 0.151 ± 0.008 L/h/kg, 0.235 ± 0.012 L/kg, and 1.14 ± 0.07 h, respectively. The maximum plasma concentration of orally administered Phe-Ψ-Ala (2.31 ± 0.60 µg/mL) in the presence of Gly-Sar was significantly decreased compared with that in the absence of glycylsarcosine (3.74 ± 0.44 µg/mL), suggesting that the intestinal absorption of Phe-Ψ-Ala is mediated by intestinal PEPT1. In conclusion, our results indicate that Phe-Ψ-Ala is a high-affinity, metabolically stable, non-radioactive probe for PEPT1, and it should prove useful in studies of PEPT1, e.g., for predicting drug-drug interactions mediated by PEPT1 in vitro and in vivo.
Shuoye YANG, Zhixia QIU, Qiuyang ZHANG, Jiayin CHEN, Xijing CHEN
[Advance Publication] Released: July 15, 2014
The present study investigated the effect of calf thymus DNA (ctDNA) on human hepatic cytochrome P450s (CYP450s) in vitro. Specific substrate probes for each isoform, CYP1A2, 2C9, 2C19, 2D6 and 3A4, were incubated using pooled human liver microsomes with or without ctDNA, and liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) method was developed for the analysis of probe metabolites. Enzyme kinetics parameters Ki and IC50 values were estimated to determine the types and strength of inhibition. ctDNA could specifically inhibit the metabolism of CYP2C9 probe substrates, with the IC50 = 0.9955 µg/ml, while it was not able to inhibit CYP1A2, CYP2C19, CYP2D6 or CYP3A4 (IC50 > 100 µg/ml). The results showed that ctDNA was a potent inhibitor of CYP2C9 enzyme, and has the metabolic interaction potential with the model drugs which are metabolism substrates of CYP2C9. The inhibition mechanism study suggested ctDNA may inhibit CYP2C9 by decreasing the activity of CYP450 reductase. These findings indicated that when the medical agents catalyzed mainly by CYP2C9 were co-administered in vivo with adsorptive material in vitro, the potential inhibitory effect of ctDNA on enzyme activity and the following metabolism character changes of the former should be highly focused on.
Takuro KOBORI, Shuhei FUJIWARA, Kei MIYAGI, Shinichi HARADA, Kazuo NAKAMOTO, Takayuki NAKAGAWA, Hideo TAKAHASHI, Minoru NARITA, Shogo TOKUYAMA
[Advance Publication] Released: July 22, 2014
Altered expression of P-glycoprotein (P-gp), a drug efflux transporter expressed by brain capillary endothelial cells (BCECs), may contribute to the development of opioid analgesic tolerance, as demonstrated by cumulative evidence from research. However, the detailed mechanism by which chronic morphine treatment increases P-gp expression remains unexplained. Ezrin/radixin/moesin (ERM) are scaffold proteins that are known to regulate the plasma membrane localization of some drug transporters such as P-gp in peripheral tissues, although a few reports suggest its role in the central nervous system as well. In this study, we investigated the involvement of ERM in the development of morphine analgesic tolerance through altered P-gp expression in BCECs. Repeated treatment with morphine (10 mg/kg/day, s.c. for 5 days) decreased its analgesic effect in the tail-flick test and increased P-gp protein expression in BCECs, as determined by Western blotting. Furthermore, moesin protein expression increased in the same fraction whereas that of ezrin decreased; no change was observed in the radixin expression. Furthermore, immunoprecipitation and immunofluorescence assays revealed interaction between moesin and P-gp molecules, along with co-localization, in BCECs. In conclusion, an increase in moesin expression may contribute to the increased expression of P-gp in BCECs, leading to the development of morphine analgesic tolerance.
Masayuki SAKIYAMA, Hirotaka MATSUO, Yuzo TAKADA, Takahiro NAKAMURA, Akiyoshi NAKAYAMA, Tappei TAKADA, Shin-ichiro KITAJIRI, Kenji WAKAI, Hiroshi SUZUKI, Nariyoshi SHINOMIYA
[Advance Publication] Released: May 27, 2014
ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP) is a xenobiotic transporter and also regulates serum uric acid levels as a urate transporter. We have shown that the severity of ABCG2 dysfunction can be estimated by simple genotyping of two dysfunctional variants, Q126X (rs72552713) and Q141K (rs2231142). This genotyping method is widely accepted for the risk analysis of hyperuricemia/gout, but there is no report on ethnic differences in ABCG2 dysfunctions. Here, we estimated ABCG2 dysfunctions by its genotype combination (Q126X and Q141K) and compared them in three different ethnic groups (500 Japanese, 200 Caucasians and 100 African-Americans). The minor allele frequencies of Q126X and Q141K in Japanese (0.025 and 0.275, respectively) were significantly higher than those in Caucasians (0.005 and 0.085, respectively) and African-Americans (0 and 0.090, respectively). Additionally, the rates of mild, moderate and severe ABCG2 dysfunctions in Japanese (35.4%, 12.4% and 1.6%, respectively) were higher than those in Caucasians (14.0%, 2.5% and 0%, respectively) and African-Americans (14.0%, 2.0% and 0%, respectively). Because ABCG2 dysfunctional diplotypes were commonly observed in both Caucasians (16.5%) and African-Americans (16.0%), the genotyping of the two ABCG2 dysfunctional variants is useful for evaluating individual differences in the ABCG2 dysfunction which affect the pharmacokinetics of substrate drugs and hyperuricemia risk in all three ethnic groups.
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AIDS Serology
There are multiple tests to detect the antibody to HIV. HIV is the virus that causes AIDS. The U. S. Public Health Service requires that an enzyme immunoassay (EIA) and another confirming test such as a Western blot or an immunofluorescence assay be used to be certain that a person has evidence of an HIV infection.
ELISA, an EIA test that stands for enzyme linked immunosorbent assay, tests for antibodies to HIV in the blood. It does not detect viral antigens (pieces of the virus themselves). Because of this it cannot detect infection in the earliest stages when the body has not formed antibodies yet to fight off the infection. This period of time may vary from a couple weeks to 6 months. This time period is important because during this period of time a person with a negative test can still be HIV infected and still give the disease to another person.
No preparation or fasting is required. A blood sample is taken by a needle from a vein.
A normal value is a negative test. This means that at this time, your test does not show you have an HIV infection. Remember, it is possible to have an HIV infection and not test positive in the beginning of the infection so it is important to have the test repeated, and sometimes up to 6 months following exposure.
No evidence of HIV antigen or antibodies.
Ranges for normal findings may vary among different laboratories and hospitals. You should always check with your doctor after having lab work or other tests done to discuss the meaning of your test results and whether your values are considered within normal limits.
Your caregiver will go over your test results with you and discuss the importance of this test. A positive test for HIV today does not have nearly the significance of ten years ago. There are many new and very successful treatments available. Although this is true, an HIV infection is still a fatal illness. There is no known cure. All precautions should be taken to avoid passing this on to someone else or a loved one through unprotected sex.
Make sure you receive the results of your test. Ask how these results are to be obtained if you have not been informed. It is your responsibility to obtain your test results.
Your caregiver will discuss your findings with you and the value of this test to you. Your caregiver will provide further instructions or treatment options if necessary.
Other tests are now available for detecting HIV which use oral fluids or saliva. These tests are the oral mucosal transudate (OMT) tests. They use the same technology as the ELISA and Western blot tests. Urine is also tested now for HIV.
If home tests are used for concerns about an HIV infection it is important to follow up and understand your results. Some of the home tests provide toll-free pre-test and post-test counseling. If you have a test result you are concerned about, get help or counseling from your caregiver. Remember, it is possible to have an HIV infection and not test positive in the beginning of the infection so it is important to have the test repeated, and sometimes up to 6 months following exposure. This precaution is repeated because it is very important.


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Sonic Boom Race
BEST BETDATE: June 29 2013, 7:45 AMCost:$40.CATEGORY: Sports and RecreationVENUE INFORMATION:Lucky Pie Louisville
Cyclists maneuver through the streets of downtown Louisville for a chance to win the title of Colorado Master Criterium Champion. After the race, reward yourself with a beer and a slice at the Lucky Pie Pizza & Tap House afterparty. Sat 7:45 a.m.
More Information:
Visit www.sonicboomracing.com.


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We have been running Zimbra Network Edition for the last 18 months. We have a company of 50-60 mailboxes. Within the last few months, I have noticed the server load (via 'top') is often pegged at 8-11 and always at least 3. A full backup takes over 14 hours to complete for a 180GB mail store.
The machine response seems to be much slower than it was 6 months ago. The machine (Poweredge R200) runs on a single Xeon 3GHz/6M Cache E3110 dual-core processor. It has 4GB of RAM and 250 GB of disk space.
I am considering replacing the server it is currently on to new machine but am not sure how it should be spec'd out. Anyone else running a similar sized shop with any advice would be appreciated.


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American Home Furnishings
Retail - TI's and RenovationsNext Project
- Conversion of 140,000 s.f. Super Kmart
- Incorporated walls, doors, windows and flooring materials imported from around the world
- Extensive rework of HVAC, lighting and electrical
"It has been enjoyable working with a crew/team who has commitment to my project and is looking out for my best interest....bottom line, they lay things out like they are, honest, and straight forward."
Dallas Broad
American Home Furnishings


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Monday Afternoon News, March 24
Le Mars Man Charged For Distributing Cocaine
(Le Mars) -- The Le Mars Police Department have arrested a Le Mars man for the distribution of cocaine. Early Sunday morning, 41 year old, Corey Dailey of 408 1st Avenue Northwest, was taken into custody without incident in the 10 block of 1st Street Northwest for two counts of delivery of a controlled substance. Both are Class C felonies. Dailey was taken to the Plymouth County jail where his bond was set at $20,000.
Le Mars Librarian To Leave For Another Position
(Le Mars) -- Le Mars is searching for a new director of library services. Sue Kroesche has submitted her resignation effective April 25th. Bill Cole, assistant city administrator says Kroesche has accepted another librarian position in another city. Kroesche had been the Library Director for the Le Mars Public Library for five years.
City Issues Water Quality Report
(Le Mars) -- The Le Mars City Water Department has issued its annual Consumer Confidence Report to the Iowa Department of Natural Resources, showing residents the quality of the city's water. Gayle Sitzmann, superintendent for the water department says Le Mars has good quality water with very low amounts of contaminants.
Listen to
Sitzmann says the state is especially interested in the nitrate level of local water supplies. He says that is a direct result of fertilizer run-off.
Listen to
The city water superintendent says Le Mars is fortunate to have a good supply of high quality water, and he says it should continue long into the future.
Listen to
Copies of the Consumer Confidence Report can be obtained by contacting the city water department.
Wells Fargo Bank Warns of Scam
(Sioux City) -- A new scam has hit northwest Iowa. Cell phone users are receiving text messages, presumably from Wells Fargo Bank, directing people to go to a phony website and enter their private account information. Angie Kaipust, a spokesperson for Wells Fargo Bank, says the bank and its customers are victims of a "phishing scam".
Listen to
Kaipust suggests if you receive such a message, just erase it, and don't act upon it.
Listen to
The bank official reminds people that the bank does not need to ask for private account information, because they already have it.
Listen to
One customer reported falling victim to the scam, costing him $1700. Kaipust says if people believe they are the victim of a bank scam to contact their bank immediately.
Listen to
Turkey Processing Plant To Remain Closed Until Tuesday
STORM LAKE, Iowa (AP) - Company officials say the fire-damaged turkey plant in Storm Lake is expected to remain closed through Tuesday.
Saturday night's blaze caused a portion of the roof to collapse at the Hillshire Brands plant. One firefighter was injured but was soon released after treatment at a hospital.
Fire crews from four departments were sent to the plant, which employs around 600 people.
The cause of the fire is being investigated.
People Unable To Pay For Utility Bills
DES MOINES, Iowa (AP) - Thousands of Iowa households are behind on their utility bills in the wake of winter's subzero weather.
The Iowa Utilities Board figures say that as of February, more than 243,000 households were in arrears - 4 percent more than a year ago. But because of the severe cold and the higher costs of natural gas and propane, the amount of the debt has hit $46 million - 40 percent more than the figure in February 2013.
William Brand is administrator of the Low Income Home Energy Assistance Program in Iowa, and he says 38,000 of the Iowa households in the program are behind on their bills by a total of $11.7 million. April 1 marks the end of the winter moratorium on utility shutoffs for those households.
State Senator Still Trying To Get Medical Marijuana Legalized In Iowa
DES MOINES, Iowa (AP) - Legislation to legalize medical marijuana in Iowa has been declared dead this session, but lawmakers are continuing with efforts to raise awareness about benefits associated with the drug.
Sen. Joe Bolkcom, a Democrat from Iowa City, invited current and former Iowa residents to the Capitol on Monday to share how marijuana has helped them medically and explain why they have left or are considering leaving the state.
A mother from Waterloo says she uprooted her family to get her epileptic daughter medical marijuana in Colorado. A veteran suffering from post-traumatic stress disorder says he plans to move to Colorado, too.
Gov. Terry Branstad has said he fears there would be unintended consequences if medical marijuana were legalized.
A Quinnipiac University poll shows 81 percent of Iowans support medical marijuana legalization.
Branstad Orders Secret Settlements To End
DES MOINES, Iowa (AP) - Gov. Terry Branstad says he has signed an executive order prohibiting state agencies from signing confidential settlement agreements.
Branstad, back in Iowa from vacation, is responding to criticism of agreements reached between state agencies and several state employees who were fired and then paid more than $280,000 to keep quiet.
Branstad says Monday that Iowans expect more from state government and deserve better. He says he didn't know about the settlements.
His order requires settlement agreements to be reviewed by the attorney general's office and all agreements to be posted on a state website.
He's also ordered all past settlement agreements to be posted - that's more than 321 since he took office. He says 24 contain confidentiality agreements and 10 included lump sum payments to workers.
Branstad Supports Work Force Director
DES MOINES, Iowa (AP) - Gov. Terry Branstad is standing behind the director of Iowa Workforce Development who has been criticized by Democratic lawmakers for allegedly improperly pressuring judges who hear unemployment cases to rule against workers and in favor of employers.
Branstad says he has tremendous confidence in Teresa Wahlert and says she's an outstanding administrator and very fair.
He calls the criticism last week led by Sen. Bill Dotzler, of Waterloo, a partisan political attack.
Dotzler sent a letter to the U.S. Department of Labor asking the agency to investigate whether Wahlert is violating federal laws requiring fair and impartial administration of unemployment benefits.
He alleges Wahlert has created a hostile work environment and interferes with the independence of administrative law judges.
Wahlert and Branstad deny the accusations.
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After winning their first district game in six years, the Leopards kept the momentum going and won their second district game in a row.
Teryn Schmidt led the Leopards in scoring with 27 points.
Alex Miller and Jeanette Lopez each scored 9 points.
The Leopards lost to Pettus, 83-45 on Jan. 24.
Teryn Schmidt led the team in scoring with 23 points and Karly Nichols scored 14 points.
Last week's competition brings the Leopards season record to 4-23, 2-6 in district play.
The Leopards will play Falls City at home Friday night. Game time is 6:30 p.m.


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Glavni sadržaj | Navigacija u kategoriji
Start / end date: 26.10.2006. / 27.10.2006.
Organiser: Museum Documentation Centre
The international symposium dealing with the theme Museums and Literature, organised by MDC in Zagreb within the framework of marking the 25th exhibition of publishing activities by Croatian museums and galleries, will bring together museum professionals, authors and other heritage experts in order to consider the interrelationship between museums and literature.
The Museum Documentation Centre (MDC) is the central node of the network of Croatian museums that has generated a series of initiatives for promoting museum activities over the past 50 years of its existence.
By following current topics as well as contemporary museological trends, the MDC provides answers to numerous questions through its professional and reference services. The pressing topic of the literary heritage as a segment of the Croatian written heritage in museums, its shaping in museum terms according to modern museum standards, the problems of literary bequests and donations, the project of digitalising the museum, archival and library heritage, the elaboration of unified lists of the literary heritage – these are just some of the initiatives that strive to promote awareness in museums as well as among authors for an active coming together and cooperation that benefits the contemporary public.
The museum community could significantly enhance its cultural offering through approaching the life and work of authors or the works themselves both on a local, national and international stage using museum presentations.
It is our intention to bring together an interdisciplinary group made up of contemporary Croatian authors, competent literary theoreticians and historians, experts and scholars from museums and other heritage institutions from Croatia and abroad.
The symposium would be an opportunity of publicly airing and discussing their views, knowledge and experience, as well as sharing proposals and ideas linked with the idea of the museum presentation of authors and literary works. The papers and presentations delivered by invitation are aimed at shedding light on the museum presentation of authors and literary works in Croatia, as well as providing an insight into contemporary museological events on the basis of representative examples in European literary memorial institutions.
The two-day symposium will be held in the rooms of the Mimara Museum in Zagreb in October 2006 and will be accompanied by the publication of summaries and a CD-ROM with integral papers and presentations.
Organizational committee:
Professional excursions
The symposium includes a visit to the Bela and Miroslav Krleža Memorial Museum in Zagreb, and a professional excursion to Lukovdol with a visit to the Ivan Goran Kovačić Memorial Museum.


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While conceding that difficult decisions in the past to contain the fiscal deficit have caused some pain, finance minister P Chidambaram on Thursday said the government needs to continue efforts to contain the twin deficits and would take further measures to control gold imports.
Some measures may cause immediate pain but this was necessary to ensure that the fiscal deficit came down to 3 per cent in the next three years. Steps were also being taken to contain the Current Account Deficit, Chidambaram said at the NDC meeting.
The government in the recent past had hiked diesel prices by over Rs 5 per litre and capped the number of subsidised LPG cylinders to six per family in a year.
Gold imports which contributed $64 billion to the widening CAD will also have to be curbed, the minister warned. Indias CAD is expected to touch 3.5 per cent of the GDP in the current fiscal. Chidambaram also lauded state governments for containing the fiscal deficit to 2.1 per cent of the GDP.


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Another day, another bit of casting is revealed for Steven Soderbergh's male stripper pic "Magic Mike," but this one comes with a twist.
Ted Casablanca over at E! -- who has been getting all hot and bothered over the possibility of full-frontal in the film -- reveals today that actress/model Riley Keough has landed a small role in the film and apparently beat out Lindsay Lohan for the part. According to his sources she was "thisclose" to landing the gig. Of course, LiLo's people are really great at talking to the press (remember those "Man Of Steel" rumors?) so we're skeptical as to how much of a reality it was that she would be cast in the film. However, we do it believe that Soderbergh wouldn't want to deal with her baggage, particularly on a low-budget film that won't have time or money to waste.
Starring Channing Tatum, Alex Pettyfer, Matthew McConaughey, Matt Bomer and Joe Manganiello, and penned by Reid Carolin, the film will tell the story about an experienced stripper (Tatum) who teaches a younger dancer (Pettyfer) how to hustle his wares on stage and off at the exotic club Xquisite, run by Dallas (McConaughey). Keough -- who had her first screen role in "The Runaways" last year and has "Jack & Diane" coming up -- will play Pettyfer's troubled girlfriend.
Anyway, as the cast hit the gym, E! spills that one of the choice scenes will have McConaughey's Dallas instructing his dancers, "I want you to go back and f—k that mirror like you mean it!" We can't wait.


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XCOM: Enemy Unknown Free DLC Announced - NewsJake Weston, posted on 08 January 2013 / 1,360 Views
After two sets of paid DLC (one of which was free if purchasing the game new), XCOM: Enemy Unknown has another set of DLC coming its way, but this time it's free. Dubbed "Second Wave", this DLC pack is described by XCOM lead designer Jake Solomon as a way to increase the game's replayability.
"Second Wave" will achieve this by adding a series of optional perks to XCOM's singleplayer campaign. These are:
- Damage Roulette: Gives weapons a wider range of damage.
- New Economy: Randomizes council member funding.
- Not Created Equally: Randomizes starter stats for rookies.
- Hidden Potential: Promoted soldiers' stats increase randomly.
- Red Fog: Combat wounds degrade the soldier's mission stats.
- Absolutely Critical: Flanking shots now guarantee a critical hit.
- The Greater Good: Psionics can only be learned from interrogating a psionic alien.
- Marathon: The game takes considerably longer to complete.
- Results Driven: A country offers less funding as its panic level increases.
- High Stakes: Random rewards for stopping alien abductions.
- Diminishing Returns: Increases the cost of satellite construction.
- More Than Human: The psionic gift is extremely rare.
Though the previous DLC sets offered new characters, missions, and cosmetic changes, this free DLC will extend the playlife of the strategy game, described by Solomon as a way for players to "mod the game themselves."
Free DLC for one of the best games of last year? I'll take it.
[Source: IGN]
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Hi there,
I've managed to get a google calendar feed modified for my purposes. The only strange issue is that the times are now wrong. It seems they are no longer displaying in NZST (Pacific/Auckland, GMT +12). How can I get this back into NZST?
Pipe Web Address: http://pipes.yahoo.com/pipes/pipe.info?_id=af98c8ba84f8fa015ce2d81f11dd588a
Many thanks
Use a date formatter module. check out http://pipes.yahoo.com/pipes/pipe.edit?_id=af98c8ba84f8fa015ce2d81f11dd588a#5c5e6f309814b484a1e40b4d47a77011
Do those examples actually help anyone? They are very sparse on information to the point of being useless.
in Pipes


text: I am getting ready to install a new FSA K-Force Light BB386EVO crank on my Giant TCR Advanced frame with BSA 68mm BB. I will also be installing the matching BB cups that screw into the frame. The crank came with three thin metal spacers (in addition to the wave washer). I can't find installation instructions anywhere, especially not in the box or on the FSA site. Do I need to use the spacers? Under what conditions? How many? On both sides? Are they for chain line or other purpose? I haven't ever used spacers before on my standard BSA cranks with BSA BB. Thanks to anyone who can answer these questions.


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Posts Tagged 'Twin Pregnancy 29 weeks'
Twin Pregnancy at Week 29 to Week 32
Twin Pregnancy at Week 29 to Week 32
Babies' Growth in Utero
Congratulations! You've entered your third trimester. By the end of this month, the combined weight of the babies will be about 7.5 pounds, and they will each be about 1.5 feet long. All internal systems are fully developed, except for the lungs.
The babies will wake and sleep independently, and you may not be able to distinguish them from each other. If they adopt aberrant movement habits or stop moving, call your doctor right away. They should be in the correct position for labor, with their heads near the birth canal—literally in the fetal position!
Your babies can make funny faces in the womb, and even crack a smile. Their faces have filled out into a semi-round shape. They're adding fat deposits, so that they can calibrate their body temperature once they're out in the world.
Mother's Changes
Astonishingly, your body is circulating half again its regular blood volume. Just another one of the miracles of birth. Your uterus is at the stage of development that it would be at 40 weeks for a single birth. You should be gaining a pound a week.
This is a good time (and your last chance for a while) to pamper both yourself and your relationship. Get a pedicure, if you can find a salon that uses non-toxic ingredients.
Have a lovey-dovey date night, and enjoy fantasizing with your partner about what your babies will be like. Hire a babysitter if you need to, or ask a friend to sit. This quality partner time is essential!
At this advanced stage of pregnancy, your hips are expanding to accommodate the birth. Here are remedies for some physical challenges that you may face:
• Heartburn, due to slowing of digestive system, declining uterine space and increasing progesterone levels: take in smaller meals
• Leaking colostrum (pre-milk), an extremely nutrient and antibody-rich liquid: use nursing pads underneath your clothing
At the Obstetrician
Your doctor will check your twins' position to determine if adjustments are necessary. She will check your pelvis for cervical dilation, if any. This is also the month that she will complete a biophysical profile (BPP) on the babies.
Basically a physical performed on an unborn child, the BPP uses ultrasound to monitor range of motion, lung function and muscles. Electronic heart monitoring will determine the babies' cardiac health. The doctor will also ensure that the amniotic fluid is sufficient to support the twins for the remainder of your pregnancy.
You might want to undergo the BPP earlier than 32 weeks if you have any of these conditions:
• Kidney problems
• Hypertension
• Overactive thyroid
• Preeclampsia
• Unusual bleeding
• Lupus
Your Birth Plan
You'll be considering the following options:
• Elective Caesarean vs. vaginal birth
• Whether you want natural childbirth or pain intervention
• Pain relief options: narcotics, analgesics, pudendal block or epidural
These issues will be discussed at length in an article entitled Twin Pregnancy at Week 37 to 40.
A C-section in itself is not dangerous to your babies. But why might a mother require caesarean intervention during delivery?
• If labor is not advancing, because of a large infant in a small pelvis or sluggish contractions, as in one-third of all C-sections
• If babies are in distress, as when the contractions slow their hearts, because the placenta is flimsy. The cords can also get tangled, or enter the birth canal.
• If the babies are in the breech position
• Due to heavy bleeding, caused by improper placenta placement
Baby Shower
Here's a countdown checklist for planning the perfect shower. Two months before the event, choose the friend or relative that you consider to be most suitable to host the shower and be chief planner. If a group will plan the shower together, make sure that everyone understands what his or her responsibilities are.
Next, pick a weekend date that's convenient for you vis-à-vis your delivery date. Traditionally, that date is six weeks before the due date or planned C-section. Some mothers choose to hold the shower shortly after their babies are born. Although with twins, you'll need plenty of help to pull off that scenario. Plan around attendees who will need to travel a longer distance.
Pick a time of day when the expectant mother is usually at a high energy peak. A good duration for a baby shower is about two hours—don't let your guests overstay and wear out the mother-to-be!
Along with your chief planner, decide on a theme, around which you'll choose invitations, favors and decorations. Matching the theme to the babies' nursery décor is a clever idea.
Put together a guest list, coordinating the size of the party with the mom-to-be's energy level and the space available. If young children will be attending, some sort of childcare arrangement will be required—or perhaps the moms present can trade off this duty.
These instructions assume that there will be only one shower, but some people choose to do a small, family-only event and another with friends and acquaintances. Some showers even include men!
An all-important element these days is preparing a budget for the party. Making an early start will allow you to make adjustments in the cost. Perhaps the cost can be split among friends or family members.
Your budget will hinge upon:
• Number of guests
• Menu
• Cost of favors/prizes/décor/invitation
• Location
Where will you hold the shower? The usual choice is the chief planner's home. Other possibilities are a private club, restaurant or even a spa. Decide on the importance of convenient parking, how noisy the party might be, and whether the party will be held indoors or outdoors. If you decide on a public facility, reserve your chosen space right away.
What will your guests eat? Who will prepare the food? Will you serve a meal or just a snack? Do any of them have dietary restrictions? You will want to take the time of day, size of the party, your theme and your budget into account.
Be sure to plan for a surplus of refreshments. Non-alcoholic beverages are always suitable for a shower. If more than one person (or a caterer) will be responsible for the food, firm up those arrangements as soon as possible.
Choose your invitations. Consider using email or the telephone if you are on a limited budget. Handmade invitations can be fun, but they take time. You can also find free shower invitations online.


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basically I have a java program that takes two arguments from the command line like this --> findfile <PATH> <FILENAME> and searches in that path and all its sub-directories for the file name input. Right now I'm just looking to display all of the sub-directories and the files in them I assume you have to do this recursively. I have been able to get it to display all of the files in the specified path but not its sub-directories any techniques or advice?
thanks in advance guys you are the best here is my code and output
import java.io.*; public class findfile { public static void main(String[] args) throws Exception { String pParam = " "; String nParam = " "; pParam = args[0]; nParam = args[1]; File pathFile = new File(pParam); File fileName = new File(nParam); String path = pathFile.getPath(); String name = fileName.getName(); if (pathFile.exists() && pathFile.isDirectory()) { System.out.println(path + " exists!"); System.out.println("Searching..."); } else { System.out.println("Path " + path + " does NOT exist!"); } File[] contents = pathFile.listFiles(); for (int i = 0; i < contents.length; i++) { System.out.println("\t" + contents[i].getName()); } } }
This post has been edited by JazzRockFeel: 08 April 2011 - 11:04 AM


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Directory of the government structure of the United States of America. A special feature of this premium publication is the Source of Information section that lists addresses and telephone numbers for each agency identifying contacts for employment, Government contracts, publications, films, and other services available to the public.
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text: The Breast Center NAPBC-Accredited Breast Center, Pink Ribbon Facility, Breast Imaging Center of Excellence by ACR Locations > The Breast CenterText size: A- A+ About Specialty Services Downloadable Forms RN Nurse Navigator News, Events & Classes Photos, Videos & Tours Contact Us A lovely spa-like facility with friendly staff, Breast Center provides a warm welcome for women seeking all breast care services. Amenities include beverage service, Internet access, private dressing rooms, lockers, plush robes and a library. The Breast Center was the area's first to offer digital mammography as well as 3D mammography. DEXA bone density and a full spectrum of breast diagnostics are offered. For more information, visit the Breast Care section. Awards Are you at risk? Prevent & protect. Discover your heart's age Estimate your risk of Breast Cancer What contributes to back and neck pain?


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My Father in law passed away 6 years ago, and my wife and her sis are finally (long story) getting around to obtaining some of his estate items, one of which is a red 1973 Paramount.
It has been hanging in a barn unridden for the last 12 years, and as near as I can tell (I had a very quick look a few months ago) it is in perfect condition (dusty) and 100% complete. He was a guy who always had the best, and once he owned something he took very good care of it.
It has the pinstriping around the lugs, I think the last year they did this. Anyone have any opinions/info on this bike? It is almost surely coming to me and I am very excited about the prospect of being able to ride it- not only because it sounds like a great bike but to honor his passing. My wife tells me he used to take off for long trips up in Nor Cal all by himself in the 70's and 80's.


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Linda C. Turk
Linda C. Turk, 71, of Greenwood, went to be with the Lord on Friday, May 2, 2014.
Born Nov. 28, 1942, in Indianapolis to the late Horace R. and Lois White, she was a home-maker and an active member and Bible school teacher at Greenwood Church of Christ.
Linda was passionate about bowling, and enjoyed shopping, crocheting, knitting and playing video games.
She volunteered with both ALS and Leukemia organizations.
She will be loved and missed by her three sons, John A. Turk II (Donna), Jason M. Turk (Connie) and Justin N. Turk (Jackie); seven grandchildren; Katrina, Jarod, Kyra, Taiylor, Conan, Josie and Sara; brothers, Donald Horning and Mark White; many nieces and nephews; and her dog, Misty.
She was preceded in death by her husband of 47 years, John A. Turk; and brothers, Thomas Horning and Dennis White.
Visitation will be 4 to 8 p.m. today at G.H. Herrmann Greenwood Funeral Home at The Gardens at Olive Branch, 1605 S. State Road 135. The funeral service will be at 11:30 a.m. Tuesday at the funeral home. Burial will be at Forest Lawn Memory Gardens.
Memorial contributions may be made to Ewing's Sarcoma Research Foundation at esarcoma.com.
Online condolences may be shared with the family at ghherrmann.com.
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Roly Poly Killer
Compiled by Whitney Cranshaw, Colorado State University:
Colorado Insects of Interest
Roly-poly Killer
Class: Arachnida (Arachnids)
Order: Araneae (Spiders)
Family: Dysderidae
Identification and Descriptive Features: Dysdera crocata (Figure 1 and 2) is a spider of moderate-size, ranging 9-15 mm in length. The front half of the in spider (cephalothorax) and the appendages are orange or reddish orange. The abdomen is grayish white. Perhaps the most striking feature is the very large jaws and associated fangs (Figure 2).
Distribution in Colorado: An introduced species, Dysdera crocata can now likely found in residential areas statewide.
The spider is a nocturnal hunter and during the day is usually found under rocks, wood or other covering debris where isopods similarly occur. In homes, Dysdera crocata is almost always found in basements and other sites where humidity is high.
The spiders mature in about 18 months and, at least in captivity, may live an additional couple of years. Generations overlap and adults and immature forms can be found year round. Mating has been observed to occur in spring, and may happen at other times given the continuously overlapping generations of this species.
If handled their large fangs may be capable of inflicting a bite but they do not possess venom that poses any danger to humans. These are secretive spiders that are not aggressive and not harmful.
Related Species: Dysdera crocata is an introduced species of spider, native to Europe. It is the only representative of the family Dysderidae that occurs in Colorado.
The information herein is supplied with the understanding that no discrimination is intended and that listing of commercial products, necessary to this guide, implies no endorsement by the authors or the Extension Services of Nebraska, Colorado, Wyoming or Montana. Criticism of products or equipment not listed is neither implied nor intended. Due to constantly changing labels, laws and regulations, the Extension Services can assume no liability for the suggested use of chemicals contained herein. Pesticides must be applied legally complying with all label directions and precautions on the pesticide container and any supplemental labeling and rules of state and federal pesticide regulatory agencies. State rules and regulations and special pesticide use allowances may vary from state to state: contact your State Department of Agriculture for the rules, regulations and allowances applicable in your state and locality.


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Consumer Statement: Debt Free Associates pitched an easy way to pay down my debt. For a small fee, they would negotiate with my creditors to pay off my loans at a fraction of their balance. Too good to be true? It was. Not only did they charge me a huge amount of money to start my account, when it came ... Read More »
Debt Free Associates – Scam, Complaint, Review, or Praise?
Please share your experience with this debt relief company and provide your review and feedback, in the comments section below. The goal of this page is to allow people to share information that may be important to help others to make a more informed decision regarding their experience with this debt relief company. Here are some potential questions you might ... Read More »
Examples of Deceptive Official Marketing Sent Out By Debt Settlement Companies to Trick Consumers. Some are Members of TASC & USOBA.
I've seen more coy and scammy mailers being sent by companies in an attempt to trick or confuse people in debt to believe that some sort of government help is available to help them with their consumer debt. For the most part these mailers are nothing more than deceptive advertisements that try to get consumers to call and then be ... Read More »


text: Because all RPM based Linux distributions have subtle incompatibilities, it is impossible to write a setup.py script that produces RPMs that will work on all those distributions. Normally, RPMs build on a particular version of a particular distribution will work on other systems with exactly the same version of the same distribution (Paul's setup is not "normal", because his Python interpreter lives in his home directory). If anybody wants to provide RPMs, please code distribution+version in the name of the RPM. The RPM.README in the tar.gz explains how to do this. Gerard On Thursday 14 March 2002 20:42, Paul F Dubois wrote: > Gerard Vermeulen asked me to remove the RPMs from SourceForge, and I > have done so. Apparently what is made by default is not useful except > for me. > > I absolutely refuse to learn about RPMs; it is not useful for my job. If > the RPM-cult wants this stuff to work then I need patches to setup.py > that ALWAYS produce a suitable RPM, or a volunteer who will make and > install such files for each release. I > will run an automated test if supplied but it can't interfere with my > system or require superuser privs, because I don't have that. > > I appreciate people trying to help and I'm sorry if it wasn't clear just > how incompetent I intend to be on this. >


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The New York Rangers are on a pretty spectacular run. After defeating the Philadelphia Flyers in seven games, the Rangers found themselves down three games to one to the Pittsburgh Penguins, only to win three straight, including two on the road, … Continued
phil jackson
Mad Blog Unleashed: King Henrik!
Bill Cartwright has been 'in contact' with Phil Jackson
If Steve Kerr is the favorite to land the New York Knicks' vacant head coaching job, Bill Cartwright is the clubhouse leader to land a job as his top assistant. Tuesday on SiriusXM NBA Radio, Cartwright spoke with Frank Isola … Continued
Bill Cartwright on New York Knicks head coaching job: I'm open
If Phil Jackson were to pick up the phone and offer a former New York Knicks All-Star the head coaching job, would he listen? You bet. Bill Cartwright, who played for the Knicks from 1979 to 1988, joined SiriusXM NBA … Continued
Steve Mills takes Spike Lee through the hiring of Phil Jackson
Earlier this week, New York Knicks superfan Spike Lee sat down with Knicks general manager Steve Mills for an exclusive one-on-one interview. The full interview airs Thursday at 7 pm ET on SiriusXM NBA Radio, channel 217. Just days after … Continued
Phil Jackson: NBA needs to raise age limit
The NBA needs to make a change to its current age limit, Phil Jackson suggested Wednesday on SiriusXM NBA Radio. According to Jackson, one-and-done college players enter the league without receiving a proper education, and their pro careers suffer as … Continued


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Aerospace Engineering
Degrees Offered
Master of Science in Engineering
Areas of Study and Facilities
The concentrations for graduate work in aerospace engineering are aerothermodynamics and fluid mechanics; solids, structures, and materials; structural dynamics; guidance and control; orbital mechanics; and aerospace design. A brief description of each concentration and the experimental facilities available is given below.
Aerothermodynamics and fluid mechanics. This concentration involves study and research in experimental, theoretical, and computational aerodynamics, gas dynamics, heat transfer, and combustion. Research is presently being conducted in computational fluid dynamics, shock-boundary layer interactions, compressible shear layers, nonequilibrium and rarefied gas flows, applications of laser diagnostics, and nonlinear flow interactions. Facilities include Mach 3 and Mach 5 blowdown tunnels, shear layer and wake tunnels, a turbulent flame facility, lasers, a digital camera system, and a variety of high-speed digital data acquisition systems. In addition, a light gas gun for the acceleration of projectiles up to five kilometers per second is available for studies of chemically reacting and hypersonic flows. The excellent computational facilities include a variety of workstations and access to the Cray supercomputers.
Solids, structures, and materials. This concentration involves study and research in mechanics of composite materials, fracture mechanics, micromechanics of materials, constitutive equations, structural analysis, and structural stability. Experimental facilities include equipment for static structural testing; digital data acquisition equipment; uniaxial and biaxial materials-testing machines; custom loading devices; environmental chambers; microscopes; photomechanics facilities, composites processing equipment, and facilities for microstructural analysis. Computing facilities include workstations, supercomputers, and networks of workstations.
Structural dynamics. This concentration involves study and research in theoretical, computational, and experimental structural dynamics, including wave propagation. Included are aeroelasticity, linear and nonlinear structural system identification, modeling and control of flexible structures, multi-flexible-body dynamics, structural acoustics, and wave propagation in various media. Computational facilities include several workstations, and experimental facilities include actuators and sensors and several data-acquisition systems for structural system identification and control. Wind tunnel facilities are available for testing aeroelastic models.
Guidance and control. This concentration involves study and research in system theory, control theory, optimal control theory, approximation theory, estimation theory, and stochastic control theory and their application to the navigation, guidance, control, and flight mechanics of aerospace vehicles. Research is primarily analytical and numerical in nature, and excellent computational facilities are available for this purpose.
Satellite applications. This concentration involves study and research in the application of satellite techniques to a variety of problems, including active and passive satellite remote sensing for research in earth, ocean, atmospheric, and planetary science; satellite positioning, primarily using the Global Positioning System (GPS) for earth science research; and satellite tracking techniques for a variety of geophysical and geodetic studies, including the study of Earth's gravity field and rotation. Research is supported by a large database of satellite remote sensing measurements, a variety of computer workstations, GPS receivers, and image processing equipment.
Orbital mechanics. This concentration involves study and research in the applications of celestial mechanics, analytical dynamics, geophysics, numerical analysis, optimization theory, estimation theory, mathematics, and computer technology to the dynamic behavior of both natural and artificial bodies in the solar system. Research is supported by a large database of satellite measurements and a variety of computers, including a workstation cluster and a supercomputer.
Aerospace design. This concentration involves study and research in the application of all disciplines of aerospace engineering to the design of aerospace vehicles, missions, and related systems. Research is primarily applied in nature and involves the synthesis of information from all engineering disciplines, mathematics, the natural sciences, economics, project management, and public policy.
Graduate Studies Committee
The following faculty members served on the Graduate Studies Committee in the spring semester 1998-1999.
Admission Requirements
The prerequisite for graduate study in aerospace engineering is a bachelor's or master's degree in aerospace engineering or in a related field of engineering or science. Graduate study in orbital mechanics is possible for those with degrees in engineering, science, or mathematics.
Degree Requirements
Master of Science in Engineering. Students seeking the master's degree have three options. The thesis option requires thirty semester hours of coursework, of which six hours are given for the thesis course. The report option requires thirty-three semester hours of coursework, of which three hours are given for the report course. The option without thesis or report requires thirty-six semester hours of coursework. Regardless of the option chosen, a student is required to take six hours of supporting coursework outside the major. Students receiving financial aid through the sponsorship of the department are expected to choose the thesis option; however, those in aerospace design may choose the report option. Master's degree students may not count courses taken on the credit/no credit basis toward the degree. They are also limited in the number and level of business-related courses that may be counted.
The following is a template for the student beginning the MSE degree program in a fall semester. A student who follows this schedule will be considered to be making satisfactory progress toward the degree.
Doctor of Philosophy. The PhD program consists of coursework, qualifying examinations, and the dissertation. Students who have master's degrees must complete at least twenty-four hours of coursework; those who enter the graduate program with bachelor's degrees must complete at least forty-eight hours of coursework.
To be admitted to candidacy for the Doctor of Philosophy degree, the student must pass both a written and an oral examination. The written examination is general in nature and covers subject matter studied through the first year of graduate work. The oral examination is in the student's specialty area and is conducted by a committee of faculty members whose interests are in that area. Students may not take courses on the credit/no credit basis until they have passed the written qualifying examination.
The following is a template for the student with an MSE degree who begins the doctoral degree program in a fall semester. A student who follows this schedule will be considered to be making satisfactory progress toward the degree.
For More Information
Campus address: W. R. Woolrich Laboratories (WRW) 215D, phone (512) 471-7595, fax (512) 471-3788
Mailing address: Graduate Program in Aerospace Engineering, Department of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, Texas 78712-1085
E-mail: firstname.lastname@example.com
URL: http://www.ae.utexas.edu/
|Top of File
|Graduate catalog
Contents |
Chapter 1 |
Chapter 2 |
Chapter 3
Catalogs | Course Schedules |
Academic Calendars
Office of the Registrar
University of Texas at Austin
2 August 1999. Registrar's Web Team
Comments to firstname.lastname@example.com


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text: Man in court over firearms 13 Jun 2014 A north Belfast man has been remanded into custody accused of having a sawn-off shotgun, rifle and semi-automatic pistol. Share Share Share Story by UTV Staff, Belfast Denis Patrick O'Keefe was arrested after police raided two houses in north Belfast on Thursday.The 49-year-old, of Little Georges Street in the city, faces three charges of possessing a firearm in suspicious circumstances.O'Keefe was detained along with a 17-year-old youth during the PSNI operation on Thursday.Searches were carried out at properties in the Hillman Street and Little Georges Street areas.Appearing before Belfast Magistrates' Court on Friday, O'Keefe did not seek bail at this stage.He was remanded in custody with a view to mounting an application to be released next month.Meanwhile the teenager, who was questioned on suspicion of drugs offences, has been released on police bail pending further enquiries. © UTV Share Share Share


text: Sale Rustic Natural Accent Table Item #: 133681 $79.99 $55.99 Qty: Sorry, this item is currently unavailable online. Ship to Home Ship to Store (FREE) Bring a touch of the great outdoors into your home with the Rustic Natural Accent Table! This small accent table will add a subtle touch of organic, earthy style to your room's décor. Table measures 18L x 18W x 25H in. Crafted of wood Distressed natural finish Features one (1) drawer with antiqued brass pull handle Features one (1) lower fixed shelf Weight capacity: 50 lbs. Not intended for commercial use Care: Dust with a soft, dry cloth. Avoid using chemical or abrasive cleaners as they may damage the finish. This item is available at Kirklands.com only, not available in stores. Sorry, this item is currently unavailable online.


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Inked Girls: Day'Jai
Myself in a sentence: Myself is unique, daring, strong minded about everything i speak about. Im the black sheep thats doesn't follow the trend i create it. Im true to my desire while others don't think.
Occupation: n/a
Hometown: Goldsboro NC
The design and themes of my tattoos: ll of my ink re symbol or represent me. I wouldn't not get anything that didn't, because i call that not being or truthful to yourself. Its your body, don't fix something that's not broken. We all have flaws, you got to accept yours and know hked ow to control it.
More specifics about my tattoo: I love my ink, they are like my accessories to me. I would feel naked and plain without them. My tattoos didn't create me personally, but i feel they apart of me. I can write a book on more specifics on my tattoos, just because their that important and i've grown attached to them.
My favorite tattoo and the story behind it: My favorite tattoo on my body is the one on my chest that says "Super Bad". The first thought most people think is extremely pretty , or being the "bad guy". The definition is within the eyes of the beholder. This tattoo means three words , brave, strong, and risk taker. These three basic sounding words is really three things you need to live. I come from the insecure, low self-esteem bullied childhood. I believe its not where you came from it is where you becoming. You should not let criticism control your life or it will control your life. I overcame my troubles within myself, this what made me strong. I put myself in situations to find myself this makes me a "dare-devil" or of course a risk taker. Last being unique, you got to learn how to feed off negative, command respect without speaking, and deliver your word while being fearless. How you gone win, if you not right within? You need these qualities if you want to get far with your dreams.
My next tattoo: I want my next tattoo to be a picture tattoo of my passed away grandmother. She was like my twin even though she is older in age. She helped me with my confidence today. I have the middle name that were given to me by her. I try my best to live to the life she didn't get the chance to. This is one of motivations to follow m dreams, to soon become reality.


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Okay, so it's kind of a no-brainer. Then again, the brilliant, off-the-wall author of Hell's Angels, Fear and Loathing in Las Vegas, and plenty of other vivid chronicles of the 60's and 70's was an irascible pro-gun maverick who liked to keep people -- especially his editors -- guessing.
I bring all this up because I just saw Gonzo: The Life and Work of Dr. Hunter S. Thompson, the new documentary by Alex Gibney. (It comes out Friday.) Gibney, as you may recall, made Enron: The Smartest Guys in the Room. He also won an Oscar this year for Taxi to the Dark Side, his exposé of prisoner abuse by the U.S. military in the War on Terror. So he's no political slouch. And after two and a half years making a movie about Thompson, who died in 2005, he felt pretty confident declaring Obama would have been his man:
"He was a Bobby Kennedy guy, he was a McGovern guy. He liked the idealists, the people who urge us to reach for a better possibility, rather than the fear-mongers like McCain who say, 'We gotta be afraid,' and 'Trust me, I'll protect you from the bad guys,'" Gibney told me at a pre-screening gathering in New York last week.
Perhaps to a fault, Thompson was one to pick sides. He savaged McGovern's Democratic opponents in the 1972 campaign, which he covered for Rolling Stone and later devoted a book to. "There is no way to grasp what a shallow, contemptible and hopelessly dishonest old hack Hubert Humphrey is until you've followed him around for a while," Thompson wrote. And he helped sink the Muskie campaign with a report (fictitious, it was found, after the damage had been done) that the Maine senator got regular drug fixes from a shady Brazilian doctor. He only wrote Muskie was rumored to be hooked on Ibogaine, Thompson tells a talk-show host in archival footage in the film. "Which is true," he adds. "I started the rumor."
Thompson, as Brian Williams notes in an on-air eulogy early in Gonzo, was a "complex walking monument to misbehavior." (Just after I talked to Gibney, Tom Wolfe recalled the time he invited Thompson out to lunch in New York. His guest blasted a marine-distress siren in the restaurant.) But even if there's no one like Thompson in today's press corps, not by a longshot, the current political moment does have more than a few things in common with that one.
"First of all, there's a war at the heart of it," Gibney pointed out. "McGovern wants to end the war, Obama wants to end the war. There's this sense of a misguided mission overseas, and there's a tremendous rumbling all about that. And then there's this fight for the nation's soul, between this great sense of idealism and possibility and then also this fear and loathing, this darkness, this 'Fuck 'em, we're gonna go rip their lungs out' kind of thing."
Gibney, who edited Taxi and Gonzo in side-by-side cutting rooms, has been alternating his film subjects lately, between Bush-era corruption and 60's idealism. "I think it's important to kind of cleanse the palate," he explained. At the moment, he's working on a documentary about Ken Kesey and the Merry Pranksters. He's also trying to secure distribution for one about disgraced lobbyist Jack Abramoff. "I thought I was making a film about a bad apple, and it turned out to be about a rotten barrel," he said. It may take several bathtubs full of Kesey Kool-Aid to wash that one down.


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Director Katie Mitchell's Feminine Mystique
LONDON—Thomas Heywood's "A Woman Killed with Kindness," now directed by Katie Mitchell at the National Theatre, premiered in 1602. Designers Lizzie Clachan and Vicki Mortimer's sets and costumes update the twin plots to 1919.
Both are set in the living quarters of the protagonists, and most of the activity on stage consists in moving the furniture about between scenes. But Ms. Mitchell has slashed Heywood's long domestic tragedy (so called because the characters are middle-class rather than Shakespearean royals or grandees) to just over two hours, dispensing with many of the male characters' soliloquies. The original has five acts, the last of which contains 17 scenes.
There's a further problem with the playwright's text: It is unclear about the passing of time. So the director has those playing the many servants whizzing the chairs, tables and furnishings into the wings or up and down the staircases every few minutes, in a fashion that clarifies the changing of the seasons as well as the changing fates of the characters. It is done with acute attention to detail, but in a speeded-up manner reminiscent of the cinema.
The designers have cleverly filled the big stage of the Lyttelton auditorium with parts of two houses joined together, so that the old-money Sir Charles's country house is on the audience's left, and the newly bourgeois John Frankford's grander house is on the right.
Heywood's Anne Frankford cuckolds her husband John (a steady performance by Paul Ready) with his charming but poor protégé, Wendoll (played drolly and, at one point, entirely unclothed—this is a feminist version, after all—by Sebastian Armesto). Ms. Mitchell's Anne (Liz White, who evokes real pathos in her deathbed scene) has an additional, wordless scene that shows she has had a painful, bad wedding night. This, of course, alters Heywood's balance of guilt, as it gives Anne a motive for adultery apart from base passion.
In the parallel plot, Sir Charles Mountford (a gawky characterization by Leo Bill) saves his fortune by the forced marriage of his sister Susan (an electrically charged Sandy McDade) to their hated enemy, Sir Francis Acton (a phlegmatic Nick Fletcher).
Her husband discovers Anne's affair but punishes her minimally, simply sending her away from him and their children. She vows to starve herself to death, and is thus, in the curtain line Ms. Mitchell takes from her husband's speech and gives to the blighted Susan, "a woman killed by kindness." She, and Susan, have only one matter they can control: their own deaths.
Until Sept. 11
Write to Paul Levy at email@example.com


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Krantiguru Shyamji Krishna Verma Kachchh University has recently published the M.ED. Merit List Year 2013-14.The results are already available online. Students can check the results on the official website.Candidates Who Read More
http://kskvku.digitaluniversity.ac Archive
September 9, 2013|
KSKVK University Results of BSc 4th Semester CBCS Repeater Exams 2013
September 4, 2013|
KSKVK Results of B.Com 2nd Semester Exams 2013
August 27, 2013|


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Hopes and fears for science talks in Nairobi
This month a meeting will take place in Nairobi in Kenya where scientists, including a delegation from IUCN, will meet with the world's governments to advise them on the best way forward to save all life on earth, the planet's biodiversity. The conference, known as the Subsidiary Body on Scientific, Technical and Technological Advice or SBSTTA, is a crucial part of the Convention on Biological Diversity. Decisions taken in Nairobi will provide a scientific basis for the convention, which will meet in Nagoya in Japan later this year.
Jane Smart is the Director of IUCN's Biodiversity Conservation Group. She says that this year's talks, to stem the loss of biodiversity, are critical.
02 May 2010 | Audio
What next for biodiversity targets
The 2010 biodiversity target was adopted in May 2002 during the sixth Conference of the Parties to the Convention on Biological Diversity. It aimed to achieve, by 2010 'a significant reduction of the current rate of biodiversity loss at the global, regional and national level as a contribution to poverty alleviation and to the benefit of all life on earth'. Unfortunately, the latest analysis of the IUCN Red List shows this target has not been met. As we are facing an ever-increasing biodiversity crisis, we need a new, clear and realistic target to respond to it. …
01 Mar 2010 | Audio


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May 27, 2016
Have you ever watched Wheel of Fortune and thought you could do better than the contestants?
Well, Ray Matheny of Lauderdale, Miss., found out for real when he got on when the show was taping in Biloxi.
Matheny is a guidance counselor at Harris Elementary and the public address announcer at Meridian High School football games.
His episode will air Jan. 9, after Newscenter 11 at Six. We can't tell you how he did, but we think you'll be proud!
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.