text:
"Sweet Home Alabama" is one of those songs that needs no introduction. As an official anthem of the South and a song that's found its way into movie soundtracks, it is so much greater than the members of Lynyrd Skynyrd ever dreamed it would be.
All these years later, and you can still hear people young and old singing those famous words, "Big wheels keep on turning..." Even those who have no idea who Skynyrd is (which aren't many), know "Sweet Home Alabama" by heart.
During their live shows, "Sweet Home Alabama" is still one of the major highlights for fans. Since the song always manages to fire up the crowd, Skynyrd decided to film an official live video for it at one of their shows.
The performance was driven by the crowd's excitement, which only continued to grow as the song went on. We could point out individual elements of this performance that made it so great, but we'd end up naming every moment that occurred!
Seriously, what isn't there to love about this performance? You've got the stellar triple guitar work, Billy Powell's magic hands gliding over the keys, and Michael Cartellone rockin' it out on the drums. Lead singer Johnny Van Zant's performance was also on point, and it looked like he was having the time of his life up there on stage.
We're sure everyone in the crowd was having the times of their lives watching Skynyrd put on such a great performance. Now it's your turn to check it out in the clip below.
This is why after all this time, Skynyrd still reigns supreme in the world of Southern rock.
Lynyrd Skynyrd's 'Pronounced 'Lĕh-'nérd 'Skin-'nérd & Second Helping Live' is available now on DVD, Blu-ray and digital formats - it's the perfect gift for the Lynyrd Skynyrd fan in your life. Buy it here on Amazon!
Interested in becoming a partner?
Contact us for more info.


text:
Originally set up to provide the jet set with their most outlandish whims at a moment's notice, the concierge company and private members' club has had a radical change of direction.
It is opening a model agency with a difference: super-skinny waifs are banned. The firm believes this will help it grab a slice of the top agencies' multimillion-pound profits.
With its rivals under fire for promoting the size-zero fad, Quintessentially Models refuses to endorse the ultra-thin look. It markets itself as the first "ethical" agency, citing health as a central consideration. Models have access to nutritional advice as well as help from Barclays to manage their finances.
So far Quintessentially has signed up 128 models, who in turn have won contracts with Olay, Nivea and Lancome. But industry analysts remain sceptical the agency can take on the giants ofUK modelling such as Premier, Storm, IMG, and Models 1.
Quintessentially was launched in December 2000 by Elliot and Aaron Simpson, still its two biggest shareholders. It has 41 offices worldwide.
- More about:
- Fashion Models
- Intel Corporation

subset: commoncrawl


text:
The Australian actor, writer, producer and director Michael Pate had an enormously prolific career – he was in such demand in 1953 that Columbia Pictures wrote to the director of the film El Alamein, in which he was appearing, asking him to "Please kill Michael Pate before noon". But he is possibly best remembered as the writer, producer and director of the popular film Tim (1979) which gave Mel Gibson, who played a handsome but backward young man who is nurtured by a middle-aged woman (Piper Laurie), his first major opportunity.
Pate was also the first actor to portray James Bond's CIA counterpart Felix Leiter (transformed into an MI6 agent) in a live 1954 television version of Casino Royale starring Barry Nelson as "Jimmy" Bond, with Peter Lorre a formidable villain. In a long-running television series, Matlock Police (1971-75), Pate played a country detective, and he won several awards for his productions of both dramatic and variety shows for Australian television. In 1990 he received the Medal of the Order of Australia for his services to the performing arts.
Born Edward John Pate in Sydney in 1920, he performed in pantomimes and in the school choir as a boy, and on graduation from Fort Street Boys High he joined the Australian Broadcasting Commission as an actor and writer, as well as writing a volume of short stories. He made his professional stage debut in 1938 in Elizabeth and Essex at Sydney's Minerva Theatre.
After serving in the Army's entertainment unit during the Second World War, during which he served as compere for the touring performances of Gracie Fields, he began to act in films, and in 1950 he supported Tommy Trinder and Chips Rafferty in Bitter Springs. Telling of the conflict between settlers and Aborigines, it was the last (and least successful) of the three films made in Australia by Ealing Studios after the war.
Pate also acted in a stage version of Charlotte Hastings' thriller, Bonaventure (1950), and he made his Hollywood debut when Universal asked him to repeat his role in Douglas Sirk's enjoyably melodramatic screen version of the play, retitled Thunder on the Hill (1951) and starring Claudette Colbert as a nun turned sleuth, proving the innocence of convicted murderer Ann Blyth. Pate remained in the USA for several years, appearing in more than 200 films and TV shows. He was Flavius to Marlon Brando's Marc Antony in Julius Caesar (1953), played a droll Sir Locksley in Danny Kaye's funniest comedy, The Court Jester (1955), and was frequently cast as a Native American in such films as Hondo (1953) and The Great Sioux Massacre (1965) and countless television westerns including Maverick, Laramie, Have Gun – Will Travel, Gunsmoke and a memorable episode of Rawhide in which he saved the stars, Eric Fleming and Clint Eastwood, from being flogged while tied to tree trunks.
Pate had had a short-lived wartime marriage, but, after his divorce he wed the actress Felippa Rock, daughter of the film producer Joe Rock, in 1951, and with her brother, Philip Rock, Pate wrote the screenplay for the Western Escape from Fort Bravo (1953). In 1959 he returned to the stage with Judith Anderson in Medea, and in the same year he was a priest in Green Mansions, starring Audrey Hepburn. In 1968 he returned to Australia, where he produced Age of Consent, starring James Mason and a then little-known Helen Mirren, whose nude scenes boosted the film's takings in Australia, but were edited out by British censors.
Mel Gibson was also little known when Pate cast him in Tim (1979), based on a book by Colleen McCullough. Pate gave the tricky subject – a middle-aged woman teaching a youth with learning difficulties and ultimately marrying him – delicate handling, which resulted in a tasteful and touching tale. Pate won a Best Screenplay award from the Australian Writers' Guild, and Gibson won the Australian Film Academy award as best actor for his performance – later the same year he gained international fame with Mad Max.
In 1982-84 Pate toured Australia co-starring with his son Christopher Pate in Mass Appeal, ending with a season at the Sydney Opera House. Though he retired in 2001, Pate was working on a script at the time of his death.
Tom Vallance
Michael Pate, actor, director and writer: born Drummoyne, New South Wales, Australia 26 February 1920; married twice (one son); died Sydney, New South Wales, Australia 1 September 2008.
- More about:
- Actors And Actresses
- Cinema
- Film Directors
- Mel Gibson


text:
1 Bedroom North Zealand, Hornbćk, Gilleleje villas
Less than 30 properties found matched your exact date search. So properties with availability close to your requirements have also been included.
just a moment loading data..
A number of locations have been found that match your search, please select from one of the following:
Message Area
17 displayed of 17 properties found, no date selected
17 properties match your search, showing 1 to 17
Page 1 of 1 : 1


text:
Motorola's Buds not only take headset comfort to a whole new level, but also make your mobile lifestyle easier than ever with its innovative design and advanced sound quality.
Easy on the ears, these buds feature a lightweight, countoured design and soft, flexible ear cushions with micro-adjustable stems that fit anyone, anywhere. The collar wraps around your neck and the buds pop in and out as you need them with the magnetic attachment at the tips of the collar. Clean, efficient and stylish.
You can enjoy HD audio with advanced noise cancellation, ridding you of annoying background sounds so both ends of your call are clear and crisp. After pairing with your mobile Bluetooth device you have 150 feet of freedom with these buds. Handsfree just got a whole lot easier!
Please Note: Product images, including color, may differ from actual product appearance.
Universal Compatibility: Works with any Bluetooth enabled cellphone or smartphone.
Shop with Confidence
Expert advice available weekdays 8am-5.30pm ET at (877) 799-0143
"Once again thank you for your wonderful customer service. I deal in the customer service industry everyday and really appreciate it when I come across a company that does an above average job of customer service. I will give you the best compliment that I know of - I will refer you to others."
- Casey, FL


text:
Saratoga Springs Fall Guide
Fall in Love with Saratoga Springs this Autumn!
Fall is one of the best seasons to visit Saratoga Springs. Crisp, cool air and autumn leaves slowly changing around the town, and the beauty only begins there. Saratoga comes alive in the fall, and there's so much to see and do! The parks are alive with the colors of autumn, there are nature trails to walk, foods to eat, and mountains to climb, with views sure to take your breath away.
Visit some of the Saratoga area's best apple orchards and pick up some sweet, crunchy apples or enjoy a savory cup of hot apple cider and an apple cider doughnut or two.
Hike in Saratoga Spa State park and explore the numerous trails. Walk through arches of vivid colors and soak in the beautiful and remarkable surroundings. Enjoy a stroll around town and let your gaze wander to the historical homes and architecture throughout. Saratoga Springs is full of history waiting to be explored!
If it's raining, don't worry, Saratoga makes rainy days entertaining. Explore some of the many museums found throughout Saratoga including the National Museum of Dance. You could also head to a local bakery or cafe, sit down to a book and a pastry at Mrs. London's or enjoy a hearty sandwich and good company at Putnam Market.
If you're in Saratoga for Halloween, you'll be in for a treat! (And maybe a trick or two). The Saratoga Fall Festival is an annual weekend long fall event full of family, fun, and food. Saratoga comes alive to celebrate the best of fall and spectators can enjoy a variety of activities from magic shows and pony rides to cupcake decorating and spooky trolley rides.The weekend culminates with the long standing costume parade!
Whatever your tastes, Saratoga Springs during autumn is sure to have something for everyone to enjoy!
Looking for fall foliage in Saratoga and the surrounding areas? Check out our leaf peeping guide!


text:
Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Melvin Shiffman, MD offers the services of a General Practitioner in Tustin, CA. A General Practitioner offers physical examinations, cholesterol testing, wound care, pap smears, immunizations, skin biopsies, fitness programs, stress reduction plans, ongoing evaluations, bone density testing and menopause treatment among other services.
Please call Melvin Shiffman, MD at (714) 544-1720 to...
Be the first YellowBot user to add photos or videos of Shiffman Melvin A MD
Shiffman Melvin A MD can be found at Bryan Ave 1101. The following is offered: General Practice Medicine. The entry is present with us since Sep 10, 2010 and was last updated on Nov 14, 2013. In Tustin there are 18 other General Practice Medicine. An overview can be found here.
Dr. Melvin Shiffman, MD, specialist in surgery, plastic and reconstructive surgery, and surgical oncology, currently sees patients in Tustin, California.
Dr. Shiffman graduated from Northwestern University (1957).
In addition to having active medical licenses, Dr. Shiffman has successfully passed a background check including a medical license verification (active) and screening for...
If you don't see your business listed on YellowBot, please add your business listing.
YellowBot wants to get your input! If you have a comment, find a bug or think of something neat we should do, let us know by emailing us.
© 2007-2017 Solfo, Inc. – All rights reserved


text:
Items in Cart:
Condition: Very good, almost unused
Origin: Bulgaria
Material: natural wool 100 %
Dimensions: 220 cm x 150 cm
Weight: 3000 g
Shipping method: Registered mail international
The Rhodope – the Mountain of Orpheus
Natural Woolen Bulgarian Blanket, Country style
There are used only natural materials!
Hand crafted from the Rhodope region, famous for its master craftsmen.
Woven on hand loom.
Very warm natural wool blanket for your bedroom.
Recommended washing temperature 40 degrees Celsius


text:
Groundwater Jobs
The NCGRT is happy to help advertise Australian and international groundwater job opportunities as a free service to the groundwater community. Current jobs are listed below.
You can create new job advertisements or sign up to receive new job notifications. Advertisements will be checked by the NCGRT before being added to this page.
Also keep an eye on the NCGRT's LinkedIn Group, The Australian Groundwater Forum, which also offers a jobs page that people can advertise on.
Jobs by Closing Date
|Assistant Professor of Water Policy, Politics and/or Planning — University of California, Santa Barbara
|United States
|Academic Jobs at the University of Saskatchewan — University of Saskatchewan


text:
Each month, Rated People connects over 50,000 homeowners with quality tradesmen - simply enter your job details in the form above to get started.
We'll match your job to the relevant tradesmen in your area - those interested will pay to see your contact details and call you to quote.
As each tradesman expresses interest in quoting on your job, we'll send you their profile and ratings to help you choose the right one for you.
After the work is complete, return to the site and rate your tradesman based on their quality of work, reliability and value for money.
Added 03/03/2017
weekly cleaning service for 3 bed semi
Added 27/02/2017
a cleaner, for approximately one morning/afternoon a week to clean and hoover offices, kitchen...
Added 16/02/2017
Clean oven inside plus all trays door etc
Added 07/12/2016
This is a Stoves range style cooker with seven gas burners, two ovens, grill and warming drawer....
Added 10/05/2016
Carpet need to be cleaned in 1) 2 bedroom 2) living room In an town centre apartment.
Added 25/01/2016
I have beige carpet on the stairs and landing and a back bedroom that needs cleaning. It's...
Managing your job is easier with the Rated People Homes App, download it today.


text:
1. Something potty
This Friday to Sunday, top potters will gather in the lovely grounds of Hatfield House to show off their mugs and jugs. There's a Henry Moore exhibition in the garden. Tickets: adult £8, plus Moore, £17; seniors £7.50, plus Moore, £16.50.
*Hatfield House, Hatfield, Hertfordshire. Visit artinclay.co.uk
2. Prototypes and experiments at Aram
Until August 27, Aram's famous summer show this year looks at casts and moulds. See Peter Marigold's Malayalam 2010 and Sarah King's ball bangle, plus moulded furniture and even shoes.
*Aram, 110 Drury Lane, Covent Garden, WC2; 020 7557 7526; thearamgallery.org
3. Chicheley Hall
This glorious Georgian manor (pictured) hosts a "floral festival" from Friday to Sunday, masterminded by celebrity florist Judith Blacklock with displays, workshops and a shopping marquee, and featuring a host of top international floral designers.
*Chicheley, Newport Pagnell, Buckinghamshire. Tickets £15 in advance, £20 on the day; visit fleur-events.co.uk
4. The Alternative Village Fete
On August 28 and 29 at the South Bank, browse stalls for arts, crafts, bunting, cakes, sweets, jams, candyfloss, smoothies and vintage finds, plus music and theatre.
*National Theatre Square, South Bank, SE1. Sunday 1pm to 5.30pm; Monday, 1pm to 4pm. Free.
5. The Work Shop
A Kingston University, this is a pop-up shop, open seven days a week and kitted out by art students and new graduates at the cutting edge of design to sell greetings cards by Vic Riches, plus paintings, prints, furniture and homeware.
*Market House, The Market Square, Kingston upon Thames. Call 0779 5575494 or 0781 6682576 — or visit the-work-shop.org
Follow us on Twitter @HomesProperty, Facebook and Instagram
- More about:
- Gallery


text:
The NFLPA nearly dissolved itself with last week's CBA negotiations petering out (before two subsequent extensions), and the players were ready to take the NFL to court.
Sports Illustrated's Jim Trotter (via Peter King's Monday Morning Quarterback column) writes the union was five minutes from officially decertifying to allow its members to pursue antitrust litigation against the league.
An unidentified player tells Trotter:
"I don't know that guys were itching for a fight, but we have been preparing for this so we're not at all nervous about pulling the trigger or stepping into that world. We all agree that if we can get a deal done that is fair, then it's best to do it between the two sides. But we're prepared to do it through the courts if we have to. We've been stalled by them for so long. For two years they've been jerking us around, to be honest with you. On Wednesday their owners came to a meeting and said they were going to go to Dulles (airport) and have another meeting among themselves, then we would get back together that night to discuss things. Then they all got on planes and all went home and didn't tell us anything. They left us sitting in the mediation room for the second time.
"It just feels like we're always coming up with a new way to please them. It feels from our side like we've bent over backwards and made a number of creative proposals to them, all without getting the financial justification that they need a new system. Then they do things like hop on a plane and leave without telling us that they're leaving. We're not overanxious to pull the trigger on decertification, but we're definitely not hesitant."
Now the league and union have another four-and-a-half days to avert that course of action.
"We're ready to go," the player said. "If this is what it's going to take for them to negotiate fairly and take us seriously as partners, then let's do it.
"Honestly, most players come from the background where if their backs are being pushed against the wall they're going to fight back. They're not going to turn and cower. That's just the DNA of most NFL players, because that's what got us here. It's that survival skill and that ability to fight in pressure situations that has got us to this level. That's what you're seeing right now and will continue to see as we go forward."
Nate Davis is a reporter, blogger and editor who's been at USA TODAY since 2000. He has covered the NFL since 2005. No, he did not play quarterback for Ball State. Davis' succession of our esteemed colleague Sean Leahy at The Huddle is considered a Brady-for-Bledsoe swap by most "insiders."More about Nate


text:
Для получения актуальных цен по гостинице Genusshotel Restaurant Alpenblick, пожалуйста, укажите интересующие вас даты и выполните поиск.
A warm welcome to the Tavern Alpenblick in the flower village Lingenau.Discover rural flair with style to enjoy and feel well.Our "Alpenblick" incorporates homely atmosphere, familiar open-mind, a kind of coming back home which you really don?t know - during summer and winter - with all its attraction! Our slogan is come as a foreigner but leave as a friend! Especially our partners would like to make your holidays to an unforgettable discovery!!We would like to give you a second home !!
Номеров: 29


text:
Forgot your password?
Don't have an account? Get Started
Already have an account? Log in here
Only show results in Virginia? Ok
Related terms for "car engine exhaust measurement equipment ":
exhaust measurement companies
, exhaust measurement equipment companies
, engine exhaust measurement companies
, engine exhaust measurement equipment companies
Since 1994, REI has been an industry leader, providing customers with cutting edge technology to meet their waste and recycling challenges and helping them turn their commercial waste into revenue. REI goes to great lengths to produce equipment that drives a measurable difference in safety, economics, the environment and energy consumption while continuing to offer ...
based in Newton, NORTH CAROLINA (USA).
Environmental Measurements approach is relationship orientated as we are a privately owned company which is flexible and without corporate overheads and restraints. Throughout all our years of trading, Quality and Safety has been a priority and we have a strong belief in the value of our people and their performance. The principals in Environmental Measurements have been ...
based in Dublin, IRELAND.
Polychem Systems sales representative for eastern Pennsylvania, southern New Jersey, Maryland, and Virginia, USA. Geiger Pump and Equipment Co., represents the premier manufacturers in the US for Fluid Handling Equipment and Sealing Devices. We bring to the mid-Atlantic marketplace best in class application engineering and order processing as well as off the shelf ...
based in Aston, PENNSYLVANIA (USA).
carda engineering has since 1995, mainly specialized in the purchase and sale, as well as the mediation of Used Machines, as in: Used filter presses, used decanter centrifuges, used mixers, used disintegrating machines and mills, used pumps, diverse used equipment. Through our extensive worldwide client contacts we export over 70% of our used machines abroad. In ...
based in Mauer, GERMANY.
APCO Equipment is proud to represent many of the top manufacturers in our industry. We back these products with an extensive parts inventory and factory certified technicians. We can provide parts and service 24/7.
based in North Las Vegas, NEVADA (USA).
SONNEK Engineering was founded in 1930 and today it`s a competent full-range supplier for complex liquid technology challenges. The field of activity contains a lot of industrial sectors & fields of application. The technical solutions contain products of international renowed manufacturers that have contracts with SONNEK Engineering as well as goods and services from the ...
based in Vienna, AUSTRIA.
IM GmbH offers handheld flue gas analysers for commercial combustion analysis as well as flue gas analysers for industrial applications. Exhaust gas analysers (IM 1100F, IM 1440F) are used for emission measurements on forklift trucks. They can be used to measure exhaust gases & soot on diesel forklift trucks (TRGS554) and CO emissions (DGUV79) on gas powered forklift ...
based in Heilbronn, GERMANY.
We specialise in the measurement of air pollutants both at the source, through manual source emission measurements and continuous emission monitoring, and at ambient air quality levels through ambient air quality monitoring.
based in Lynnwood Ridge, SOUTH AFRICA.
Meaco Measurement and Control providing a range of environmental monitoring and control equipment to include data loggers, handheld devices, humidifiers, de-humidifiers and controllers. Specialising in environmental monitoring and control for museums, archives and galleries. We pride ourselves in a flexible approach and a high level of customer service. We have a loyal ...
based in Newcastle under Lyme, UNITED KINGDOM.
Hanley Measurement & Control was established in 1981 to provide Instrumentation and Control Equipment for Process & Manufacturing Industries and Public Utilities. Hanley Measurement & Control offer a comprehensive range of measurement and control devices which utilise the latest technology advancements to ensure quality, reliability, accuracy and cost effectiveness. ...
based in Swords, IRELAND.
We are a Cape Town (South African) based consulting engineering practise specialising in acoustics. Our areas of expertise are: Architectural Acoustics - Acoustics design for conference centres, auditoriums, commercial office spaces. Industrial Noise Measurement and Control - Design and measurement of noise and specification to achieve noise control for mineral processing ...
based in Cape Town, SOUTH AFRICA.
Brüel & Kjær is a world leading manufacturer and supplier of sound and vibration solutions. We help our customers solve their sound and vibration problems – from measuring traffic noise and vibration in car engines to evaluating building acoustics and performing quality control. We have customers in a wide range of fields, including automotive, aerospace, consumer goods ...
based in Nærum, DENMARK.
Wilson Equipment Company traces its beginnings to 1889 when B.B. Wilson founded the Wilson Buggy Company of Lexington. Over the years our company has adapted steadily to new technology and market preferences, but our commitment to service and taking care of our customers has never changed. Today's Wilson Equipment Company is the same company that promised to provide ...
based in Lexington, KENTUCKY (USA).
TASK Environmental Engineering is specialized in emission treatment and odour control installations. According to the customer`s needs we build a complete turn-key plant, we take care of the entire renovation and/or optimization of your existing emission treatment/odour control or waste water treatment plant. We also supply specific equipment, such as jet aeration ...
based in Heist-op-den-Berg, BELGIUM.
IMR Environmental Equipment, Inc. is one of the leading manufacturers worldwide for portable flue-gas analyzers and stationary flue-gas analyzers using electro-chemical and NDIR technology. Furthermore, the product range includes leak detectors (HC, refrigerant), thermometers, manometers and anemometers. IMR has almost 30 years of experience designing, manufacturing and ...
based in St. Petersburg, FLORIDA (USA).
Sansom Equipment Limited is an Atlantic Canadian owned Company. Our Company specializes in sales, parts and service of municipal, environmental, industrial, marine and construction equipment and accessories. Sansom is one of the most diversified companies in Atlantic Canada. We strive to provide quality products and services on a consistent basis which meet or exceed the ...
based in Truro, NOVA SCOTIA (CANADA).
Serving the farming community of Ohio since 1952. Please browse our website to see how Sterling`s unmatched Sales, Service, and Parts departments can help with your farm equipment needs. We carry a large selection of new and used tractors, implements, skid steers, planters, balers, lawn and garden equipment and much more! We feature quality equipment by Case IH, Kubota, ...
based in Sterling, OHIO (USA).
SenseAlyze Process Measurements is committed to your operation's needs, bringing 30 years of experience in the Northwest in process instrumentation, industrial wireless communications and motion control. Time is money, thank you for your time.
based in Bothell, WASHINGTON (USA).
Vector Process Equipment Inc. specializes in process equipment and solutions for the municipal and industrial markets in Canada. Based primarily in Ontario we cover Ontario, Quebec and the rest of Canada depending on the company represented.
based in Mississauga, ONTARIO (CANADA).
Lakeview Vineyard Equipment Inc. is the leading choice for all your Vineyard and Orchard equipment needs. We supply the best products in the industry and have the experienced staff to keep your operation growing. Lakeview Vineyard Equipment Inc. strongly supports research and innovation in viticultural and agricultural fields. We stand behind all of our products and aim ...
based in Niagara-on-the-Lake, ONTARIO (CANADA).
Need help finding the right suppliers? Try XPRT Sourcing. Let the XPRTs do the work for you
Join our growing community of environmental professionals who are currently subscribed to weekly newsletters, product alerts, job alerts, and our monthly event updates and article newsletters. Stay up-to-date with the global environmental industry. Sign up for one or all of our free newsletters and alerts today.
Past issues
The personal data that you provide is subject to our Privacy Policy.
Thank you for subscribing to our eBulletins
You can modify your subscriptions at any time by logging in to your Environmental XPRT account.
Minimum 250 characters
Already have an account? Login here


text:
Oppo R9s Plus Full Review And Price In Bangladesh
Oppo R9s Plus : Oppo Mobile company Lunch their R Phone Named
Oppo R9s Plus .It is a better mobile phone other R . It comes with nice design
and user friendly . All the features are good and eye catching looks. This Mobile built in
Android OS, v6.0.1 (Marshmallow).. and it has a good display with HD view features.
6 inch HD Display . processor is Octa-core 2.0 GHz Cortex-A53..
Back camera has 16 MP and font camera has 16 MP . It has a good Non-Removable Li-Po 4000 mAh battery..
easy and flexible option for on this Oppo R9s Plus mobile phone.
Oppo R9s Plus Full Review And Price In Bangladesh
Version And Processor :
Version :Android OS, v6.0.1 (Marshmallow).
processor :Octa-core (Quad core 1.95 GHz Cortex-A72 + Quad core 1.44 GHz Cortex-A53).
GPU :Adreno 510.
CHIPSET :Qualcomm MSM8976 Pro Snapdragon 653.
Apple iPhone 7 plus
Network System :
Sim :Dual sim support and Dual Standby
3G : Yes.
2G : Yes
Bluetooth :Yes, V4.0
OTA : Yes
WiFi : Yes , With Hospot
USB : Yes
Navigation : Yes
Hot-Spot : Yes .
Memory of this Phone :
SD Card : 128 GB.
Camera of this phone:
Primary : 16 MP.
Secondary : 16 MP
LED Flash : Zoom, etc. .
Features :Phase detection autofocus, Geo-tagging, touch focus, face detection, HDR, Professionla Camera mode, panorama..
Video Recording :2160p@30fps, 1080p@30fps.
oppo f1s
Battery of this Phone :
Type : Non-Removable Li-Po 4000 mAh battery..
standby time : 210 Hours..
talk time :On 2G Network 19 Hours & On 3G Network 18 Hours.
Display System of this Phone :
Display Size : 6 inch size
Display type :IPS capacitive touchscreen, 16 M colors.
resolutions :1080 x 1920 pixels.
Protector : No.
Multi-touch :Yes, Up to 5 Finger..
Sensor of this Phone :
Fingerprint, accelerometer, gyro, proximity, compass, light sensor.
Multimedia of this Phone :
This phone support many type of audio and video file . Like some file
Audio file : MP3, M4A, 3GA, AAC
Video file : MP4, M4V, 3GP, 3G2,AVI, FLV, MKV, WEBM .
Music : YES .
Games : Yes.
Loudspeaker : Yes.
Radio : Yes.
Video play : 1080p@30fps.
oppo f1s
Price :Bangladesh coming soon..//..
Why You Buy This Phone
Oppo is the top seller mobile phone company in Bangladesh . So , you can
buy this phone .Oppo offer their all mobile with good design and styles
model with low price . It has some good features that many customer care in every
District . In the some past year Oppo is a good band in Bangladesh .
Please note when you visit the site
First Thanks to visit my site . In my web site I always post in many type of
mobile phone in Bangladesh . So, some mobile company update their price any
time . So , I can not show all time real price on the phone .Another problem
is the right specification about phone . I am not a customer care or sells agent .
so, I collect all the information from their official web site . Some time
they publish some specification on their site and some time replies this
specification . for this time I can not changes this information because i don t
know when they changes . All my visitor are my friend . So, if anyone saw some
irrelevant information about mobile phone please inform me via email or comment
box . As possible as i changes this information .
Apple iPhone 7
Visit my site regularly and read new post . Facebook Me
Oppo R9s Plus price in Bangladesh;Oppo R9s Plus bd price ;Oppo R9s Plus in bd ;Oppo R9s Plus price in bd;
Oppo R9s Plus photo ; Oppo R9s Plus bd price ;Oppo R9s Plus price in bd .


text:
Ladies, you could be on this app and you don't even know it, though the creator vows it's completely consensual.
TTC Women is an Instagram acoount created by Anis Litim and is exactly what you think – pictures Anis upload on Instagram of women taking the TTC who he deems as babes.
Think it's creepy? He say's, "I will make the commitment to make sure that every person posted in this account will be asked for their consent before and i will remove any picture that raise concerns…"
Full details here:


text:
We'll help you find the right solution for your needs
Does this sound like your topic?
1 total
she cant ride in car she is scared to walk any afraid of heights every thing makes her nervous
In North Carolina, as in most states, you must first be over the age of 65, or defined disabled. Assuming not over 65, you must have a governmental agency declare you disabled. This is usually acquired through Social Security Disablity (SSD). In order to be declared as "defined disabled" you should be under the continuing care of a psychiatrist, psychologist or councellor, all must have proper licensure, degree and certification. The longer the documented psychiatric relationship the better the chances. The professional attending you must be your strong advocaate, providing all records, and a detailed affidavit that strongly supports your pursuit of SSD. However, based on what little is stated, your diagnosis will probably be denied. Currently, SSD denials are at an all timne high. Countless others having more severe diagnoses have been denied on the first application.
If over the age of 65, or if in fact you are defined disabled, you must meet Medicaid programmatic limits on income and countable resources. Community based Medicaid programs have a variation in what is required. Generally, however, income over approximately $1,100 per month, and countable assets over $2,000.00 will create ineligibility. The home (if under $500,000), one vehicle, and all personal property are not countable (considered exempt).
If not 65, you probably need the assistance of a Social Security Disability attorney before filing a Medicaid application. While not an SSD attorney, if you are over 65, and can meet the eligibility criteria above, you can probably handle file the Medicaid application witout the assistance of an elder or disability law attorney.See question


text:
The 6110 is not the prettiest phone on the market, but it's well put together, with a large display and well-spaced soft keys.
The stand-out feature of the 6110 is the built-in GPS and integrated Route 66 mapping solution. However, the handset is also HSDPA powered, so you'll be able to whizz around the internet at high speeds.
C'mon, this is a Nokia, so it's blissfully easy to use as a phone. However, just as importantly, it's exceptionally easy to use as a navigation device. It puts the original Nokia N95 to shame in this area.
Absolutely no complaints about its sat-nav performance, although finding the original fix did take a few minutes. Once we were up and running, though, it was a breeze.
The phone's battery is not weak, but we would have hoped for a bit more oomph. Make sure you get hold of the in-car charger for sat-nav trips.
Review by Sunetra Chakravati,12/12/2011 3:48:38 PM
Look and feel
Ease of use
Battery life
The sat nav performance is much more realised than the N95 and is hard to fault.
The 6110 isn't geared for quick and easy operation due to the lack of touch-screen and its small display.
Nokia's first handset with built-in GPS, the N95, launched in a blaze of publicity earlier this year. This mobile tour de force not only offered sat nav capabilities, but also packed a five-megapixel camera, DVD-quality video capture, HSDPA and Wi-Fi connectivity.The Finnish giant's second device with an embedded GPS receiver, the 6110 Navigator, is no such multimedia monster. As the name suggests, it concentrates purely on the sat nav side of things. That's not to say the 6110 isn't an accomplished Symbian Series 60 smartphone - it features a two-megapixel camera, a built-in music player, 3.6Mbps-flavoured HSDPA and all the other trimmings you would expect from a contemporary smartphone. However, this time, Nokia, with help from Route 66, has got the navigation performance spot on after the less convincing N95.
The 6110 slider is a bit chunky and a tad porky at 125g. The nearest comparison would be a narrower N95, but the upshot is a well-constructed and robust device. Nokia has also varnished the 6110 in shiny plastic and this makes for a tactile and smooth handset. The slider action is also springy and polished and when opened, it reveals a nicely spaced, easy-to-use keypad. Along with a front dedicated sat nav key, the 6110 also has a customisable multimedia button, camera shutter key and hot-swappable memory card slot lining the sides.
The 6110 doesn't plump for the N95's sat nav solution where the relevant maps are retrieved over the air from a central server. Instead, it chooses the more renowned Route 66 Navigator setup. Software and UK street-level maps are already installed on a 512MB microSD card (around 200MB is left for storage of other multimedia bits) and it's just a case of firing up the sat nav via the dedicated front key. It opens up with a Google Earth-style globe and homes in on your current position.
Finding a GPS fix took a good five minutes from a cold start, but the 6110 is now helped by A-GPS (Assisted GPS), which uses an internet connection to download info on the satellite's predicted positions to speed up the process. Once it warmed up, subsequent satellite links were much quicker. It's important to know that the GPS receiver is located in the top right-hand side of the 6110, so to get a satellite fix, you must be outside, keeping the handset facing skyward.
After finding your position, you can then plan your route. The Free Text search facility is one of the best features on the 6110 and is painless to use. Just enter a postcode, street or business name, restaurant or airport name and it will delve into its database and find the relevant addresses within seconds. If you want to be more accurate, you can type in a partial or complete address, navigate to a nearby POI (Point of Interest), use your address history, access My Landmarks (favourites) or navigate to your synchronised contacts (great for business trips). The 6110 will also let you plan journeys with multiple waypoints.Calculating a route is quick and accurate and the 3D maps are rendered brilliantly on the 6110's bright and detailed 2.2-inch QVGA, 16-million colour screen. Unfortunately, Route 66 has packed a lot of info into a small space, so it can be hard to make out what's on the screen when you glance over while driving. You can de-clutter by selecting which POIs you want displayed, although you'll find yourself relying entirely on the voice commands for directions. The absence of a touch-screen does make operation a little fiddly (although we recommend, if you're driving, to pull over before tampering with it).
The 6110 also packs two large rear speakers for announcing the turn-by-turn voice instructions, and these arrive loud and clear over the noise of the engine on a motorway drive. The device also has a pedestrian option, so you can be guided on foot and you can MMS friends and family a map of your current position. Sadly, dashboard or windshield mounts aren't supplied with the 6110, so you will have to visit the Nokia online shop (shop.nokia.co.uk) and invest in a CR-48 Mobile Holder and HH-12 Easy Mount to secure the phone while driving.
If you're in the market for the 6110, then the navigation feature will be the number one priority, but this smartphone also has capable multimedia talents. It runs just like countless other Symbian Series 60 smartphones - easy to use and ripe for third-party software - while you get a two-megapixel snapper with a neat active sliding lens cover. This shutterbug takes decent snaps, despite underperforming on close-ups, and video is shot in a respectable but still judder-tastic 240x320-pixel resolution. A full HTML web browser lets you surf the mobile internet over fast HSDPA speeds (networks only support max speeds of 1.8Mbps despite being future proof for 3.6Mbps), while business types can retrieve their emails, get organised with its PIM functionality, or view documents on the Quick Office app suite.
The Nokia N95's sat nav performance was diluted by all its other features jostling for attention, but the 6110 shows how it is done without the added distractions. GPS-enabled mobile phones still can't topple dedicated rival systems for functionality and ease of use, but they're getting close. The 6110 Navigator is perfect for those who spend their life on the road and need a convenient convergence package to keep them company on their travels.


text:
TiE Angels
About this Program
TiE Angels is an investment forum formed by Charter Members of TiE Silicon Valley, a non-profit dedicated to promoting entrepreneurship.
Our Investment Focus
Before applying, see www.tieangels.com for complete details.
TiE Angels evaluates opportunities quarterly to invest in seed and Series A rounds of promising startups. Focus areas include software/infrastructure, Internet, mobility, cleantech, and medical devices/technologies. TiE Angels seeks investment opportunities from strong teams with proven domain expertise, clear value proposition, and demonstrable competitive advantages. TiE Angels members typically invest up to $300,000 in a given investment. It is generally expected that companies presenting to TiE Angels have not received any prior funding from a venture capital firm. To facilitate interaction between portfolio companies and members of TiE Angels, submissions from companies located in the San Francisco Bay Area are strongly preferred.
Preferred Industries
- Clean Technology
- Healthcare Services
- Internet / Web Services
- Medical Devices and Equipment
- Mobile
- Software
Preferred Locations
- United States


text:
More than ever before, business executives today truly understand the inherent power that information technology can provide in terms of making better business decisions. The real challenge in finding value in Big Data isn't so much mastering any given set of advanced technologies — it lies in combining technologies in a way that adds value to the business by making it simpler to achieve results. For that, CIOs are turning to applications running in the cloud.
Rather than requiring an IT organization to stitch together technologies, tools and databases to analyze massive amounts of Big Data, cloud services like Amazon Web Services Marketplace empower end users with a robust set of analytics options that are easy to integrate, adopt and leverage. To achieve the same result on their own, CIOs would need to acquire and deploy all the IT infrastructure required to support a Big Data analytics application, develop or license an application, test and validate software, and then develop an application programming interface to efficiently share the data.
Once CIOs gain an efficient way to access and analyze their Big Data, they want to leverage that data to become more confident in the decisions they are making. They want to clearly see how those decisions might impact the business both before, and after, they are made. Visualization tools enable business users to visually inspect data in a way that gives them that confidence.
Traditional analytics platforms frame Big Data within the context of a period of time, but that can be limiting to the data's value. For example, it's fairly straight forward to understand how many units of something were sold over a particular period of time. It takes a much more sophisticated approach to learn both when and where those units were sold.
Location can be critical to corporate performance metrics when additional factors can have an influence on sales and a business' bottom line. For example, weather patterns have a direct effect on retail traffic. Ideally, business managers operating in a retail setting should be able to easily correlate weather events to forecast the impact that weather might have on their retail sales.
Gaining actionable, real-time insights not only leads to better decision-making, but making decisions at just the right time. Commercial use cases for advanced analytics now include everything from a marketing and advertising application being used to import over 15 billion records per day from 110 million smartphones, to applications being used by insurance companies to minimize risks. In the public sector, a plethora of federal and state agencies are partnering with pharmaceutical companies to better identify where outbreaks of diseases are occurring.
Combining time and location within a single query requires geospatial analytics. In the past, the only options CIOs had when it came to processing those queries was to either invoke extensions to a standard relational database that compromised performance, or deploy a geospatial database that required dedicated expertise to run it. The end result was that very few organizations wound up doing either.
Traditional SQL databases can be adapted to support GIS applications, but the results are often suboptimal for numerous architectural reasons. As a consequence, supporting these requires a lot of work and expertise on the part of a database administrator and often still yields disappointing results. Alternatively, IT organizations can deploy their own spatial database which is optimized to run GIS applications. But those organizations need to fund dedicated DBA experts to manage a system that won't meet the scale and performance demanded by users and analysts and must still deal with the issue that databases don't render interactive graphics.
With the advent of the cloud, however, it's easier to invoke a geospatial database service that end users can use to self-service their analytics needs using robust visualization tools embedded within the cloud service itself.
Today, organizations have access to all kinds of location-based data that is being generated by everything from end users keying in data on mobile devices to thousands of sensors continually streaming data. Spatial queries involve geometric computations which are often compute-intensive. Geometric computation is not only used for computing measurements or generating new spatial objects, it's also needed to establish topology relationships. Spatial cross-matching or overlaying multiple sets of spatial objects on an image or map can easily wind up being prohibitively expensive to execute.
Because of those requirements, it makes a lot more sense to take advantage of elastic compute resources in the cloud to process and render spatial data. Given the fact that demand for access to spatial analytics tends to vary wildly, dedicating IT infrastructure to service those requests on-premise not only winds up costing a lot of money, it generally takes the IT organization a very long time to set up.
The end result is that CIOs now have dynamic access to massive data sets using visualization tools that incorporate a critical geospatial dimension. Business leaders across the organization caninteractively compare and contrast how changes to data will impact an organization by rapidly exploring multiple what-if scenarios without any intervention on the part of an already overworked and understaffed internal IT department.Analysts and end users can query any combination of dimensions and visualize the data instantly, which allows them to explore areas of their data that were previously impossible to reach without support from a technical team that might take days or weeks to respond.
CIOs now have the ability to layer a wide variety of data streams into their business analysis for a more complete understanding of how different factors can impact business results. Whether it is for shipping, tracking weather patterns or resource allocation, CIOs can now visually inspect Big Data in way that gives them more confidence in their business decisions. Put it all together and it becomes clear that providing access to Big Data analytics in a way that is much simpler to consume has now become a major business priority.


text:
Magical vacation
Sail Date: March 01, 2014
Reviewed: 3 years ago
Traveled As: Family (young children)
Room Type: Balcony
Pros: The activities set before the trip were helful and fun
Cons: The stateroom were very nice but small
Recommends Disney Magic? Yes!
Category Ratings
Click table then swipe to view all columns.
Click table then swipe to view all columns.
|Children's Programs
|Service and Staff
|Cabin / Stateroom
|Small but nice
|Food and Dining
|The servers we had really made our experience magical\, but the food choices were outstanding.
|Ship Quality
|Beautiful ship


text:
Search Profile Post Profile Log In Membership Plan Site Map
Awarded as Best Matrimonial Site...
Call Us : +91-11-47652233
Profile Created for Daughter
29 years/ 5Ft. 4In. (162.5 cm)
Master Degree
Never Married
Teacher / Lecturer / Professor
Lives in India, Uttar Prade...
Hindu, Kshatriya
Detailed profile
About MI-437739
My Daughter is a Smart and Dynamic Girl Brought Up with Well Nurtured Values. She is Very Humble and Currently Living in India. She is Simple and Sensible Cheerful Fair Complexion Soft Spoken have Great Faith in Traditional Values with Modern Look Believes in Respecting Elders. Dependable and Able to Handle Any Family Situation with Great Sense of Responsibility.
All Rights Reserved - MatrimonialsIndia.Com (2017)
Web Design by WeblinkIndia.NET


text:
دانلود بازی The Sleeping Prince آیفون آیپد و آیپاد تاچ
شاهزاده ی قصه ی ما بسیار با مردم خوش برخورد است ولی طلسم شده و به
خواب عمیقی فرو رفته است
شما باید از طریق گذراندن یک سزی چالش و حل کردن پازل این طلسم را از بین ببرید
He's a handsome, strong, lovable prince, out to rescue the people of Cloudreach from an evil spell. The only problem is…he's sound asleep. Unleash the magic in your fingers to drag and toss the Sleeping Prince through a series of challenging and entertaining physics-based puzzles – reverse the spell and save the princess!
The malevolent Sydney Slime has cast a mysterious spell on the kingdom, turning it into a dormant dreamland where everyone is sound asleep. The only one who can rescue Princess Leona is our hero, Prince Perilous – but he is also under this sleepy spell.
You're the only one that can help! Use your magic to throw, flick, and toss the Sleeping Prince through the castle, towers, gardens, and rooftops to rescue the Princess and save your kingdom!
Drag the ragdoll Sleeping Prince through over 40 increasingly challenging levels. Master your flinging skills and plan your moves carefully so you don't run out of Magic!
Throw the Prince around to explore the castle, attack dangerous enemies, avoid deadly traps, and solve ingenious puzzles with smooth and intuitive physics-based gameplay.
Find and collect Gems, Stars and Z Coins in each level. The more you collect and the faster you do it will allow you to earn medals to unlock more levels! Check out Pluskin's Shop for items and upgrades to assist you during your adventure.
Rely on the King, Queen, Knight, and Wizard Plushkin's special powers to reach new heights and discover secret areas.
Please Note: A network connection is required to play. The Sleeping Prince is completely free to play, but some in-game items can also be purchased with real money. You can turn off the payment feature by disabling in-app purchases in your device's settings.
The Sleeping Prince is compatible with the iPhone 4S or newer, iPad 2 or newer, and iPad mini. For an optimal experience, we recommend playing The Sleeping Prince while awake.


text:
Matt & Nat
$148.75 $175.00
This excellent and ultra-modern Matt and Nat Dean vegan backpack by Matt & Nat is the perfect functional accessory for carrying around all of one's belongings, all while looking cool too!
This bag is made entirely out of vegan-friendly fabric with an interior made from 100% recycled nylon lining. Its functional design features a top zipper styled closure with a flip open top making it easy to both consciously place items within the backpack while remaining organized when trying to retrieve your personal belongings. Inside this fully lined bag, you'll also find a separate laptop compartment inside itself making it ideal for safely transporting your laptop from one place to another without risking damage through jostling and bumping around. On the exterior, you'll also find a separate front zippered pocket and two slide slit styled pockets. These exterior pockets are perfect for storing small items in without risk losing them within the larger compartment.
Keep your keys and bike lock in the exterior pockets while storing your laptop, moleskin notebook, and water bottle in the larger compartment – everything fits comfortably within this backpack which makes it perfect for maintaining organization.
Carry your belongings in a conscious style that's aware of its impact and remains environmentally-friendly, cruel free, and entirely vegan.
- Zipper pocket
- Slip pocket
- Logo-embossed cork tag
- Padded laptop sleeve


text:
|Publication number
|Publication type
|Application number
|Publication date
|Jan 8, 1991
|Filing date
|Sep 17, 1986
|Priority date
|Mar 25, 1985
|Fee status
|Publication number
|Robert W. Rand
|Original Assignee
|Rand Robert W
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (9), Non-Patent Citations (2), Referenced by (71), Classifications (11), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation in part of my prior application Ser. No. 715,254, filed Mar. 25, 1985 now abandoned and entitled Inductive Heating Process For Use In Causing Necrosis of Neoplasms At Selective Frequencies, the entire contents of which are herein incorporated by reference.
This invention is directed to a process of necrosing neoplasms as a result of hyperthermia of the neoplasm induced by hysteresis heating at selected frequencies of particles associated with the neoplasm.
It is a recognized medical fact that certain surgical invasions of neoplastic tumors in warm blooded animals can lead to adverse consequences. It is recognized that during the surgical removal of such neoplastic tumors, certain cells may be dislodged and entered into the general circulation of the war blooded animal to be carried to a distal site wherein an implantation of these cells occurs in the host. Growth of the neoplastic cells at the secondary site follows perpetuating the disease.
It is has further been recognized that if a neoplastic tumor could be destroyed without surgical intervention of the tumor site, the above described secondary spread of the neoplastic tumor would not occur. It is difficult enough to manage the metastasis of the tumor without further introducing secondary spread of the tumor by invasive surgical techniques.
Of the approaches taken to treat the tumor without surgical intervention of the same, the most common are radiation therapy and chemotherapy. While shortwave radiation such as X-rays and gamma rays are capable of destroying neoplastic tumors, they must, in fact, travel through overlaying body organs in order to reach the tumor site, and, if this form of radiation is not totally attenuated by the tumor, they will pass through further body organs beyond the tumor. The effect of the X-ray and gamma ray radiation on the normal body organs leads to serious side effects for this form of therapy.
Chemotherapy is also not without its side effects. The chemotherapeutic agent generally is distributed throughout the body of the warm blooded animal irrespective of its route of administration. It has been the goal of chemotherapy to develop chemotherapeutic agents which are only tumor specific acting agents and not agents which express their chemical effects on the general cellular population of the warm blooded animal. While strides have been made to develop agents which express their chemical effect on the more rapid growing tumor cells, other rapid growing body cells are also affected. This too leads to side effects in the use of these therapeutic agents.
It was suggested several decades ago to utilize hyperthermia to selectively destroy neoplastic tumors without concurrently destroying healthy tissue. Early attempts in this area involve surgical intervention into the tumor area of the warm blooded animal followed by hyperthermia treatment of the tumor site upon exposure of the same. Insofar as this technique involves surgical intervention into the body, aside from the necessity of a surgical procedure, it also potentially exposes the patient to dislodging of tumor cells and implantation of the same at secondary sites as discussed above. In order to circumvent surgical intervention into the body, induction heating hyperthermia has been explored.
In my prior U.S. Pat. No. 4,392,040, myself and my co-inventors thereof discuss certain hyperthermia procedures. Additionally, others, such as Borrelli et al, as is discussed in their U.S. Pat. No. 4,323,056, have explored this for control of neoplastic tumors. As is discussed in both of these two patents, both radio frequency and microwave frequency treatment have been explored.
Microwave radiation is utilized in diathermy. Unfortunately, the tissue of warm blooded animals is rather opaque to microwaves and the heating which results from exposure to microwaves occurs essentially at the body surface. Because of the attenuation of the microwaves by the body mass, little or no heating can be affected at deep seated points within the body cavity without excessive heating of the body surface. Because of this, hyperthermia treatment of imbedded neoplastic tumors is not possible without necrosing surface layers of the body.
In order to circumvent the above problems with prior known technologies, both myself and my co-inventors in my U.S. Pat. No. 4,392,040, Borrelli et al in the above referred to U.S. Pat. No. 4,323,056, and Gordon in U.S. Pat. No. 4,106,488 and U.S. Pat. No. 4,303,636 have suggested the use of hysteresis heating for deep seated neoplastic tumors. By exposing certain materials to magnetic fields, these materials can be heated. This heating ca be effected utilizing several mechanisms. First of these is hysteresis heating which results when these materials are positioned within an alternating magnetic field and results because of the hysteresis loss due to the varying magnetic flux on reversal of the field. The hysteresis heating is independent of particle size and, depending on the particular material, within a certain frequency range it is proportional to the frequency of the magnetic field.
A second type of heating is eddy current heating which results from current loops which are created in response to an alternating magnetic field. Eddy current heating is proportional to the electrical resistance of the conductor and is dependent upon particle size. It is further proportional to the frequency squared of the alternating magnetic field. It is known that eddy current heating can be reduced by reducing the particle size and, in fact, this technique is practiced in the electrical arts to reduce eddy current effects.
A further effect is encountered in treating biological specimens with alternating magnetic fields. This effect is dielectric heating which occurs in materials which are poor conductors. Dielectric heating results from reverse of polarization in the conductors in response to reversal of a high frequency electrical field.
As Borrelli stated in U.S. Pat. No. 4,323,056, the early implantation of powdered magnetic materials while demonstrative of the usefulness of localized induction heating to destroy neoplasms, was mitigated because of the heating of normal tissue and necrosis of the same due to dielectric heating resulting from the ionic conductivity of body tissue and fluids.
Because of the accompanying dielectric and/or eddy current heating of healthy tissue which accompanies hysteresis heating at higher frequencies, both myself and my co-inventors and Borrelli et al in U.S. Pat. Nos. 4,392,040 and 4,323,056, suggested the use of frequencies at, or below, 10 KHz, This serves to effectively eliminate destruction of healthy tissue resulting from concurrent dielectric and/or eddy current heating during hysteresis heating of metallic particles within a body.
I have found, however, that treatment of neoplastic tumors, utilizing hysteresis heating of particles within a body, at frequencies below 10 KHz, is also not without its qualifications. I have found, when warm blooded animals are placed within a coil as is described in my prior U.S. Pat. No. 4,392,040, and exposed to an alternating magnetic field in the frequency range described in that patent, and, further, as is included within the frequency range of the Borrelli et al U.S. Pat. No. 4,323,056, that the alternating magnetic field induces certain neuromuscular responses in the warm blooded animal, resulting in muscular movement and increase of muscular tone. This occurs because of the induction of minute amounts of current flow within the nerves controlling these muscles. Current flow in the nerves leads to muscle tonic and clonic contractions. This is extremely painful and, further, this condition can lead to intramuscular bleeding with the breakdown of the myosin in the muscle. The myosin can then be transported to the kidney wherein it clogs the kidney leading to kidney failure and death.
In order to circumvent the neuromuscular response, it is necessary to concurrently administer a muscular blocking agent such as curare. Curare is a general muscle relaxant and, as such, also expresses its effect on the lungs. Because of this it is necessary to anesthetize the patient under a general anesthesia and place the patient on a respirator in order to affect breathing until such time as the muscle relaxant state is removed.
In view of the above, it is the broad object of this invention to provide for a new and improved process of affecting necrosis of neoplasms in warm blooded animals. It is a further object of this invention to effect this necrosis by associating particles capable of exhibiting hysteresis heating with the neoplasm and causing said hysteresis heating of said particles. It is an additional object of this invention to effect such hysteresis heating of said particles by exposing said particles to an alternating magnetic field of a frequency which is above that which causes neuromuscular responses in warm blooded animals and which is below that wherein the tissue of the warm blooded animal exhibits either substantial eddy current and/or dielectric heating in response to the alternating magnetic field.
These and other objects, as will be evident from the remainder of this specification, are achieved in a process of effecting necrosis of neoplasms in warm blooded animals as a result of hyperthermia of the neoplasm which comprises: introducing particles into said warm blooded animal in the proximity of said neoplasm so as to associate said particle with said neoplasm, said particles capable of exhibiting hysteresis heating, said particles of a size of at least two microns in diameter so as to be incapable of being intracellularly absorbed, said particles further having a curie point in the range of 42° C. to 90° C.; subjecting the area of said warm blooded animal wherein said neoplasm having said particles associated therewith is located to an alternating magnetic field, said field of a frequency greater than 25 KHz and less than 50 KHz wherein said field is capable of causing hysteresis heating of said particles but is insufficient to substantially cause eddy current and dielectric heating of the surrounding tissue of said warm blooded animal and further said field is of a frequency greater than that capable of causing a neuromuscular response to said field in said warm blooded animal; maintaining said neoplasm within said field for a time sufficient to heat said particles and said neoplasm with which said particles are associated to a temperature of at least 42° C.
The particle size is chosen such that the particles are of a sufficient density so as to achieve efficient hysteresis heating in a localized area to effect the necrosis of the neoplasm. To achieve this the particle size is chosen so as to be a minimum of at least two microns in diameter. The frequency of the alternating magnetic field is chosen to be at least 25 KHz to avoid neuromuscular response and to be less than 50 KHz to avoid any significant eddy current heating or dielectric heating of body tissue.
This invention utilizes certain principles and/or concepts as are set forth in the claims appended hereto. Those skilled in the medical arts will realize that these principles and concepts may be utilized in a variety of different ways without departing from the scope of the invention as set forth in the claims appended hereto.
In my prior U.S. Pat. No. 4,392,040, the entire contents of which are herein incorporated by reference, I and my co-inventors describe a process and an apparatus for performing this process The process is for causing necrosis of neoplasms as a result of hyperthermia of the neoplasms resulting from injection of magnetic particles into the tissue in proximity with the neoplasm and subjecting these particles to an alternating magnetic field to cause hysteresis heating of the particles. As noted above, the particles are exposed to an alternating magnetic field below 5 KHz preferably at 2 KHz. At these particular frequencies there is little or no concurrent respective eddy current or dielectric heating of this tissue be it surrounding tissue or neoplastic tissue. This allows for the necrosis of the neoplasm as a result of the hysteresis heating without any concurrent damage to healthy tissue. Unfortunately, as noted above, the use of frequencies in this range is accompanied by a neuromuscular response which requires corrective measures of a nature requiring supportive medical personnel and apparatus. Irrespective of the supporting personnel and apparatus, anytime a general anesthetic is utilized a certain degree of inherent risk is introduced into the medical procedure.
The above referred to neuromuscular response is prevalent throughout the range of frequencies described in my U.S. Pat. No. 4,392,040, as well as those described in Borrelli et al U.S. Pat. No. 4,323,056. In a patient suffering from a neoplastic tumor wherein the prognosis is very poor, the potential side effects of a general anesthesia and of curare are of a lesser nature than the ultimate consequences of progression of the neoplastic disease state. In view of this, irrespective of any potential problems resulting from the general anesthetic or the curare, in these instances practice of the process of the above two referred to patents is indicated.
If, however, an alternating magnetic field of at least 25 KHz is utilized, the neuromuscular response to that alternating magnetic field is dramatically decreased, and, at about 30 KHz is absent. As such, utilization of an alternating magnetic field of at least 25 KHz, and preferably 30 KHz, eliminates the necessity of supportive general anesthesia and muscle relaxant therapy which is necessary at the lower frequencies indicated in U.S. Pat. Nos. 4,392,040 and 4,323,056.
Hysteresis heating of susceptible particles is achieved by positioning these particles within an alternating magnetic field. The hysteresis heating occurs upon each reversal of the magnetic field. Hysteresis heating is directly proportioned to the frequency of the field. It is further dependent upon the shape of the magnetic curve of the particle. Eddy current heating occurs in electrically conductive material and is due to current loops induced into the material when the material is positioned within a changing field. This heating is proportional to the electrical resistance of the conductor and is dependent on particle size. It is further proportional to the square of the frequency as opposed to simply the frequency for hysteresis heating. Dielectric heating occurs in materials which are poor conductors and results because of induced polarization within these conductors' in response to alternating electrical fields.
Dielectric heating in the body of the warm blooded animal results because of the ions within the fluids of the warm blooded animal. The effect of dielectric heating is utilized in a positive way in diathermy utilizing microwave range frequencies. The practice of this type of heating, however, is limited by certain restrictions based on approved frequencies approved by both the FDA and the FCC. One such approved frequency is 13.57 MHz.
Certain magnetic particles are susceptible to both hysteresis and eddy current heating. As the particle size is reduced, the eddy current heating effect is concurrently reduced. This, in effect, is utilized to advantage in the electrical arts to eliminate any current loss in certain electrical components by utilizing powdered magnetic material in these components.
When inserting particles in to a warm blooded animal, of necessity the particles must be of limited size. Therefore, eddy current heating of these particles, at least at lower frequencies, is proportionately much smaller than the hysteresis heating of the particles. The reduction of particle size results in reduction of eddy current heating of magnetic particles; but within the body tissues of a warm blooded animal, an alternating magnetic field reacting with the water molecules within the body of the warm blooded animal produces eddy current heating which increases upon increase of frequency in proportion to the frequency square. Thus, the eddy current heating of the tissue of the animal rises by a factor of the frequency squared as frequencies increased, but the eddy current heating of the particles, because of their small size, is of lesser consequence.
It is evident that while increasing the frequency of an alternating magnetic field may improve hysteresis heating of imbedded particles within the body of a warm blooded animal, this is accompanied by increased eddy current heating of the body tissues of the warm blooded animal in a mathematical relation, which leads to a greater increase of eddy current heating of the body compared to the hysteresis heating of the particles.
In saline it can be shown that dielectric heating is detectable at 500 KHz and becomes significant at about 1 MHz. Eddy current is minimally detectable at 0.4 KHz but has become significant at 100 KHz.
Gordon in the above two references patents, U.S. Pat. Nos. 4,106,488 and 4,303,636 suggests using particles which are of a sufficiently small size, smaller than one micron, so as to be intracellularly absorbed. Gordon then suggested heating these intracellular particles by inductive heating at 50 KHz to 3 MHz to heat the particles and to raise the temperature within the cells wherein the particles are located between 8° C. and 9.5° C. to selectively kill tumor cells and spare normal cells Gordon suggests that tumor cell have a far greater affinity for particles then normal cells and thus should preferentially phagocytose the particles compared to normal cells.
Contary to the suggestions of Gordon outlined above, I have found that magnetic particles of a size smaller than one micron in diameter are preferentially absorbed into certain organs of a body. These include the liver, the spleen, the kidneys, the lungs and other organs which contains reticuloendothelium. Other such organs containing reticuloendothelium would be the blood vessels, the lymph nodes, bone marrow and connective tissue.
Subsequent to the above referred to two patents of Gordons, in a later patent of Gordon, U.S. Pat. No. 4,359,453, Gordon describes the up take of particles of a size of one micron or less into the interior of atherosclerotic plaques and the phagocytizing of such particles by the endothelial and medial smooth muscle cells of the artherosclerotic lesions.
As noted above, in chemotherapy it has been a goal to develop chemotherapeutic agents which are tumor specific. While in theory it might also be a goal to develop particles which are susceptible to uptake only by tumor cells, as noted above contrary to Gordon, I have found that particles which are capable of being heated by hysteresis heating and which are smaller than one micron, can be absorbed by various body organs. In view of this I have found that it is counterindicated to utilize particles for necrosing of neoplasms by hysteresis heating of these particles if the particles are of such a small size so as to allow their uptake into cells. Introducing particles which are of a size enabling them to be taken up by the general cellular population into a body will led to concentration of those particles in certain body organs as I outline above. Even if a concentration of particles are associated with a neoplastic tumor, when the body containing the particles is subjected to hysteresis heating of the particles, the particles which have concentrated in the organs such as the liver, spleen, kidneys, lungs and other tissue containing reticuloendothelium will also be heated rendering unnecessary damage to an already compromise patient.
It is believed that neoplastic cells are susceptible to hyperthermia induced necrosis at a slightly lower temperature than are normal cells. This in fact is the basis of the above noted temperature range of the Gordons patents wherein Gordon describes heating as being done at a temperature above 45.5° C. to kill the tumor cells, i.e. 8° C. above the normal human cell temperature of 37.5° C. and 8.5° C. above tumor cell temperature according to Gordon, but below that temperature wherein the normal cells sustain damage, i.e 46.5° C. Turner, in U.S. Pat. No. 4,341,227, describes similar temperature ranges, i.e. heating above 41.5° C. to cause tumor cell damage and heating above 43° to 45° C. to cause thermal damage to most normal cells.
Because of their invasive nature and their rapid growth, if a very small population of tumor cells remains alive after hyperthermia, possible only just a single tumor cell, the possibility exist for a re-occurrence of the neoplastic disease state in the patient. In view of this, it is necessary to insure, if possible, that there is a "total kill" of all tumor cells. Even though others have suggested selective kill of only the tumor cells by selective absorption of particles by only the tumor cells, it is considered necessary to provide a sufficient particle density to insure total tumor kill even if it requires sacrificing of a peripheral margin of normal cells around the neoplastic cells. It is therefore necessary that a temperature of at least 42° centigrade be achieved in the totality of the tumor environment This cannot be achieved by selective particle uptake of particles by only tumor cells in preference of uptake by normal cells and it further requires obtaining sufficient particle density in the tumor environment which can only be achieved by particles which are of a size greater than that which can be intracellularly absorbed by the cells.
For hysteresis heating of particles, a certain density of the particles is necessary in order to effectively achieve sufficient heat in the vicinity of a neoplastic tumor in order to cause necrosis of the neoplasm. On an industrial scale, induction heating is utilized to achieve very high temperatures for certain metal treatments or the like. The articles being treated in these processes are of an infinitely more massive domain than are the particle sizes which are dispersed into the body of a warm blooded animal. Thus, for instance, an iron bar can be heated to an incandescent temperature because the heat given off by the billions of atoms is additive; whereas finely dispersed particles of the same material can only be heated to a fraction of that temperature.
I have found that particles of a size range of at least one micron are necessary to avoid intracellular uptake and the problems outline above associated with such intracellular uptake. Further particles of a size range of at least two microns are necessary in order to achieve sufficient density to effectively heat the particles and transfer sufficient heat for necrosis of neoplasms with which the particles are associated Because of these factors, an even more preferred size range would be greater than five microns since this insures no intracellular uptake of the particles and further contributes to the particle density to effective heat the tumor environment even at the expense of a few normal cells at the tumor periphery which might be sacrificed in order to achieve an effect tumor "kill".
Insofar as the particles utilized in my process are injected into the bodies of warm blooded animals, they must, in fact, be of a size smaller than the smallest capillary diameter so as to be effectively mobilized within the body of the warm blooded animal. For all practical purposes this size would be at about 50 microns. Thus, a general range of particle sizes utilized for my process would range from 2 to 50 microns with a more preferred range of 5 to 50 microns.
In order to achieve sufficient particle density within the body of the warm blooded animal in proximity to the tumors, particles of the size noted above will be utilized. Particles of the sizes noted above are of a sufficient size so as not to be intracellularly absorbed by either the neoplastic tissue or healthy tissue. If smaller sized particles are utilized such that the particles are capable of being absorbed by these groups of tissue, aside from having the particle accumulate in certain normal healthy organs as noted above followed by damage of these organs during the hysteresis heating of the particles, the individual particles are prevented by the cellular mechanism surrounding the particles from accumulating in a sufficient density in the environment of the neoplastic tissue so as to achieve the preferred heating resulting in the necrosis of the neoplastic tissue. If particles are dispersed, because of intracellular absorption, the desired density of the particle to achieve the preferred heating of the particles cannot be achieved It is generally assumed that particles of only one micron, or smaller, are capable of absorption. In view of this, for my process, particles of at least double this size, and preferably 5 to 50 times the size, are utilized.
Contary to the earlier work of both myself and my co-inventors and others, in order to avoid any neuromuscular response to the alternating magnetic field utilized to heat the particles, the particles should be heated utilizing alternating magnetic fields which are at least 25 KHz. In order to introduce a reasonable margin of error to take into account individual differences in patient response to the alternating magnetic field and other factors, a frequency greater than 30 KHz is preferred.
As noted above, in saline, eddy current heating is detectable at 0.4 KHz and is significant at 100 KHz. To insure a reasonable margin of error for the safety of a warm blooded animal by avoiding the production of significant eddy current heating in that warm blooded animal, in order to take into account any possible individual differences of biological fluids and organs in the warm blooded animal to eddy current heating in response to alternating magnetic fields the frequency wherein there is significant eddy current heating in saline, 100 KHz, is divided by two to arrive at an upper frequency limit of below 50 KHz for the warm blooded animal. This frequency is of course below the detectable onset of dielectric heating at 500 KHz. By utilizing particles of the size range described above, effective hysteresis heating of the particles can be achieved in my presently most preferred working range of from about 30 KHz to 50 KHz without concurrent neuromuscular effects evident at lower frequency ranges, and concurrent dielectric or eddy current heating effects at higher frequency ranges. This presently preferred frequency range can be extended downward to about 25 KHz without encountering severe neuromuscular response.
The particles which undergo hysteresis heating are chosen so as to have a curie point of at least about 42° C. and preferably no greater than 90° C. so as to eliminate any chance of vaporization of water in the body of the warm blooded animal and concurrent release of steam or the like. A more preferred particle range would be particles having a curie point of from about 42° C. to about 65° C. This range insures effective heating of any neoplastic tissue. The higher end of this curie point range insures tumor hyperthermic necrosis even to the expense of a limited amount of normal tissue necrosis around the periphery of the neoplastic tissue in order to insure survival of the warm blooded animal.
Preferably the particles which are utilized for producing the hysteresis heating would be ferromagnetic particles with ferrite particles being my most presently preferred particles. Commercially available ferrite particles can be utilized.
To introduce the particles into the body of the warm blooded animal in proximity of the neoplasm, the particles can be suspended in an appropriate liquid carrier. Useful as liquid carriers are my pre-polymerized polymeric mixture, as described in my U.S. Pat. No. 4,392,040, saline solution, one of many known medical contrast mediums, and/or human serum. The art skilled, upon this disclosure, will also be appraised of other suitable liquid carriers which could be utilized to introduce the particles into the body of a warm blooded animal.
|Cited Patent
|Filing date
|Publication date
|Feb 10, 1966
|Oct 28, 1969
|Amp Inc
|Method of administering therapeutic agents
|Jan 22, 1976
|Aug 15, 1978
|Robert Thomas Gordon
|Cancer treatment method
|Dec 12, 1977
|May 26, 1981
|Kernforschungsanlage Julich Gesellschaft Mit Beschrankter Haftung
|Physiological preparation containing loaded cells in suspension and a magnetic agent for local concentration thereof in a living body
|May 19, 1980
|Apr 6, 1982
|Corning Glass Works
|Radio frequency induced hyperthermia for tumor therapy
|Apr 7, 1978
|Nov 16, 1982
|Gordon Robert T
|Atherosclerosis treatment method
|Oct 12, 1979
|Jan 18, 1983
|Czerlinski George H
|Method of and apparatus for selective localized differential hyperthermia of a medium
|Jan 9, 1981
|Jul 5, 1983
|Rand Robert W
|Induction heating apparatus for use in causing necrosis of neoplasm
|Mar 8, 1967
|Dec 5, 1968
|Friedrich Dr Foerster
|Einrichtung zur Ausschaltung von biologischem Gewebe durch induktiv erhitzte Koerper mit temperaturstabilisierenden Eigenschaften
|Title not available
|Tatsuya Kobayashi et al., Magnetic Induction Hyperthermia for Brain Tumor Using Ferromagnetic Implant with Low Curie Temperature, J. Neuro Oncology, 4, 175 181 (1986).
|Tatsuya Kobayashi et al., Magnetic Induction Hyperthermia for Brain Tumor Using Ferromagnetic Implant with Low Curie Temperature, J. Neuro-Oncology, 4, 175-181 (1986).
|Citing Patent
|Filing date
|Publication date
|Dec 17, 1990
|Apr 28, 1992
|Ferrotherm International, Inc.
|Hemangioma treatment method
|Jan 29, 1990
|Mar 30, 1993
|Hypertherm Corp.
|Local application tumor treatment apparatus
|Mar 26, 1991
|Apr 20, 1993
|Gudov Vasily F
|Method and apparatus for treating malignant tumors by local hyperpyrexia
|Nov 8, 1993
|Oct 17, 1995
|Zomed International
|Device for treating cancer and non-malignant tumors and methods
|Apr 22, 1994
|Nov 21, 1995
|Tanaka Kikinzoku Kogyo K.K.
|Process of thermal treatment in tissue
|Mar 11, 1994
|Dec 5, 1995
|Zomed International
|Device for treating cancer and non-malignant tumors and methods
|Nov 8, 1993
|Jan 23, 1996
|Zomed International
|Medical probe device and method
|Apr 15, 1994
|Feb 20, 1996
|Northrop Grumman Corporation
|Magnetic resonance guided hyperthermia
|Dec 19, 1995
|Sep 30, 1997
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Jan 16, 1996
|Sep 30, 1997
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Aug 15, 1995
|Nov 4, 1997
|Multiple antenna ablation apparatus
|Aug 29, 1996
|Feb 10, 1998
|Light Sciences Limited Partnership
|Transcutaneous electromagnetic energy transfer
|Dec 19, 1995
|Apr 7, 1998
|Zomed International, Inc.
|Multiple antenna ablation apparatus and method with cooling element
|Dec 19, 1995
|Jul 21, 1998
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method with multiple sensor feedback
|Mar 15, 1996
|Sep 22, 1998
|Rita Medical Systems
|Multiple antenna ablation apparatus and method with cooling element
|Dec 19, 1995
|Jan 26, 1999
|Rita Medical Systems
|Multiple antenna ablation apparatus and method
|Nov 3, 1997
|Jun 22, 1999
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Nov 3, 1997
|Jul 20, 1999
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Oct 30, 1997
|Jul 27, 1999
|Rita Medical Systems, Inc.
|Tumor ablation apparatus
|Nov 3, 1997
|Sep 14, 1999
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Mar 25, 1998
|Nov 9, 1999
|Rita Medical Systems, Inc.
|Cell necrosis apparatus
|Nov 4, 1997
|May 9, 2000
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method with cooling element
|Feb 14, 1997
|Jun 6, 2000
|Rita Medical Systems, Inc.
|Multiple electrode ablation apparatus
|Feb 24, 1998
|Jun 27, 2000
|Rita Medical Systems, Inc.
|Cell necrosis apparatus
|Nov 17, 1997
|Jul 18, 2000
|Rita Medical Systems, Inc.
|Multiple electrode ablation apparatus and method
|Feb 6, 1998
|Oct 17, 2000
|Gough; Edward J.
|Cell necrosis apparatus
|Oct 29, 1998
|Nov 21, 2000
|Paragon Medical Limited
|Targeted hysteresis hyperthermia as a method for treating tissue
|May 9, 1997
|Dec 26, 2000
|Sirtex Medical Limited
|Targeted hysteresis hyperthermia as a method for treating diseased tissue
|Jul 7, 1999
|May 15, 2001
|Peter J. Wilk
|Medical treatment method
|May 12, 2000
|May 20, 2003
|Sirtex Medical Limited
|Targeted hysteresis hyperthermia as a method for treating diseased tissue
|Mar 3, 2000
|Jul 29, 2003
|Sirtex Medical Limited
|Heating of magnetic material by hysteresis effects
|Dec 22, 1995
|Feb 10, 2004
|Rita Medical Systems
|Multiple antenna ablation apparatus and method with multiple sensor feedback
|Sep 7, 2000
|May 25, 2004
|European Institute Of Science Ab
|Device for therapeutic purposes on human tissue, for influencing injected magnetic particles with an alternating electro-magnetic gradient field
|Dec 5, 2002
|Feb 1, 2005
|Calfacior Corporation
|System method and apparatus for localized heating of tissue
|Nov 3, 1997
|Oct 25, 2005
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method
|Sep 18, 2002
|Jan 31, 2006
|Calfacion Corporation
|System method and apparatus for localized heating of tissue
|Jul 19, 2002
|Feb 14, 2006
|Triton Biosystems, Inc.
|Thermotherapy via targeted delivery of nanoscale magnetic particles
|Dec 11, 2003
|May 23, 2006
|Apasara Medical Corporation
|System, method and apparatus for evaluating tissue temperature
|Jun 18, 2002
|Jul 11, 2006
|Erik Schroeder Handy
|Thermotherapy via targeted delivery of nanoscale magnetic particles
|Feb 3, 2005
|Mar 31, 2009
|Therm Med, Llc
|Enhanced systems and methods for RF-induced hyperthermia
|Feb 3, 2005
|Dec 1, 2009
|Therm Med, Llc
|Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy
|Nov 1, 2005
|Jun 8, 2010
|Aduro Biotech
|Magnetic nanoscale particle compositions, and therapeutic methods related thereto
|Aug 4, 2006
|Jan 18, 2011
|INTIO, Inc.
|Methods for planning and performing thermal ablation
|Oct 25, 2005
|May 31, 2011
|Allan Foreman
|Devices for targeted delivery of thermotherapy, and methods related thereto
|Feb 4, 2008
|Apr 10, 2012
|INTIO, Inc.
|Methods and apparatuses for planning, performing, monitoring and assessing thermal ablation
|Oct 9, 2009
|Oct 15, 2013
|INTIO, Inc.
|Methods and apparatuses for performing and monitoring thermal ablation
|Nov 1, 2010
|Oct 22, 2013
|Qteris, Inc.
|Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
|Mar 4, 2008
|May 27, 2014
|Angiodynamics, Inc
|Ablation apparatus and method
|Aug 22, 2010
|Feb 21, 2017
|New Phase Ltd
|Phase-change and shape-change materials
|Jul 19, 2002
|Feb 13, 2003
|Triton Biosystems, Inc.
|Thermotherapy via targeted delivery of nanoscale magnetic particles
|Dec 11, 2003
|Jun 24, 2004
|Eggers Philip E.
|System, method and apparatus evaluating tissue temperature
|Feb 6, 2003
|Aug 12, 2004
|Triton Biosystems, Inc.
|Therapy via targeted delivery of nanoscale particles using L6 antibodies
|Feb 9, 2004
|Dec 23, 2004
|Rita Medical Systems, Inc.
|Multiple antenna ablation apparatus and method with multiple sensor feedback
|Dec 15, 2003
|Feb 10, 2005
|Rita Medical Systems, Inc.
|RF treatment apparatus
|Oct 25, 2005
|Jun 29, 2006
|Allan Foreman
|Devices for targeted delivery of thermotherapy, and methods related thereto
|Nov 1, 2005
|Jun 29, 2006
|Robert Ivkov
|Magnetic nanoscale particle compositions, and therapeutic methods related thereto
|Apr 3, 2006
|Nov 2, 2006
|Rita Medical Systems, Inc.
|Ablation treatment apparatus
|Nov 1, 2005
|May 17, 2007
|Robert Ivkov
|Magnetic nanoscale particle compositions, and therapeutic methods related thereto
|Jun 16, 2006
|Dec 20, 2007
|Scientific Atlanta, Inc.
|Securing media content using interchangeable encryption key
|Aug 4, 2006
|Feb 7, 2008
|Nields Morgan W
|Methods for monitoring thermal ablation
|Mar 4, 2008
|Jun 26, 2008
|Angiodynamics, Inc.
|Ablation apparatus and method
|May 23, 2005
|Mar 26, 2009
|Universite De Geneve
|Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
|Oct 9, 2009
|Jul 22, 2010
|Nields Morgan W
|Methods and apparatuses for performing and monitoring thermal ablation
|Nov 1, 2010
|May 5, 2011
|Qteris Inc.
|Nanoparticle-sized magnetic absorption enhancers having three-dimensional geometries adapted for improved diagnostics and hyperthermic treatment
|Aug 22, 2010
|Aug 30, 2012
|Rafael Hof
|Phase-change and shape-change materials
|Feb 8, 2001
|Jul 13, 2011
|Rice University
|Optically-active nanoparticles for use in therapeutic and diagnostic methods
|Jul 8, 1993
|Jan 20, 1994
|Pappas Panagiotis T
|Method and apparatus for pulsed magnetic induction
|Nov 30, 1992
|Jun 9, 1994
|Hypertherm Corp.
|Local application tumor treatment apparatus
|Mar 3, 2000
|Sep 8, 2000
|Paragon Medical Limited
|Heating of magnetic material by hysteresis effects
|Sep 7, 2000
|Mar 15, 2001
|European Institute Of Science Ab
|Device for therapeutic purposes on human tissue, for influencing injected magnetic particles with an alternating electro-magnetic gradient field
|Feb 20, 2004
|Sep 2, 2004
|University Of Connecticut Health Center
|Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes
|U.S. Classification
|600/9, 219/628, 600/12, 219/634
|International Classification
|Cooperative Classification
|European Classification
|Jul 8, 1994
|Fee payment
Year of fee payment: 4
|Aug 4, 1998
|Maintenance fee reminder mailed
|Jan 10, 1999
|Lapse for failure to pay maintenance fees
|Mar 23, 1999
|Expired due to failure to pay maintenance fee
Effective date: 19990108


text:
[intransitive] hobnob (with somebody) (informal) to spend a lot of time with somebody, especially somebody who is rich and/or famous He was often seen hobnobbing with influential business people. Word Originearly 19th cent. (in the sense 'drink together'): from archaic hob or nob, hob and nob, probably meaning 'give and take', used by two people drinking to each other's health, from dialect hab nab 'have or not have'.verbjump to other results
BrE BrE//ˈhɒbnɒb//; NAmE NAmE//ˈhɑːbnɑːb//Verb Forms present simple I / you / we / they hobnob
BrE BrE//ˈhɒbnɒb//; NAmE NAmE//ˈhɑːbnɑːb//he / she / it hobnobs
BrE BrE//ˈhɒbnɒbz//; NAmE NAmE//ˈhɑːbnɑːbz//past simple hobnobbed
BrE BrE//ˈhɒbnɒbd//; NAmE NAmE//ˈhɑːbnɑːbd//past participle hobnobbed
BrE BrE//ˈhɒbnɒbd//; NAmE NAmE//ˈhɑːbnɑːbd//-ing form hobnobbing
BrE BrE//ˈhɒbnɒbɪŋ//; NAmE NAmE//ˈhɑːbnɑːbɪŋ//
Check pronunciation: hobnob


text:
The second half of 2016 is set to be a big one for smartphones, with the recent launch of the Galaxy Note 7, and the upcoming iPhone 7 and LG V20 reveals.
And when it comes to LG's handset, the leaks might not come as often as they do for the next iPhone, but there's still no shortage of spy shots doing the rounds.
Now, following a significant leak earlier this month, reputable tipster Evan Blass, also known as @evleaks, has posted the following image of the handset.
Related: iPhone 7
Apart from being the clearest look at the V20 we've had thus far, what else does this image reveal? Well, as it turns out, not a whole lot.
We can see that the second screen at the top of the main display, which featured on last year's LG V10, will be making a return.
There's also the fact that the bottom of the case looks to be a lot less 'modular' than the leak from OnLeaks earlier this month suggested.
Whereas the previous image showed a similar-looking base to that of the LG G5, suggesting modular capabilities, this latest render is slightly different.
Related: Best smartphone
A leak from earlier this month
In the new image, the black bar under the screen extends further down the body of the handset and features the LG logo.
Whether that means we'll see modular functionality, as with the G5, on the V20 or not remains to be seen, but it doesn't look like there'll be a lot of room for such a feature if Blass' image is accurate.
The only other thing to note is the 'in apps' icon on the screen, which is a bit of a mystery at this point.
Elsewhere, phone case maker Ballistic has also seemingly provided us with a look at the V20 ahead of its official launch.
The following image, picked up by Droid Life, seems to show the front and back of the phone in a clear case, with the fingerprint scanner and dual-camera setup clearly visible.
The V20 will launch on September 6 and will be the first phone to ship with Android 7.0 Nougat.
We'll be updating you on all the developments, and the launch itself so stay tuned for more LG V20 news.
WATCH: What's the no.1 smartphone in the world?
What do you make of these latest leaks? Let us know in the comments.


text:
Justin Bieber: Freaked Out Over Content of Seized Cell Phone?
He egged his neighbor's house (allegedly) and ended up having the cops show up to search his home, and now Justin Bieber is said to be stressing over the information contained on his seized mobile phone.
Per a report from TMZ, Johnny Law confiscated several items from the "Baby" singer's residence, including his phone, in an attempt to find evidence that would prove he hurled the eggs in question.
Justin is rumored to be worried the cops will find text messages about drugs and nude photos of either himself or girls (or both).
Meanwhile, Bieber's buddy Lil Za went to the slammer during the raid when police found him to be in possession of cocaine.


text:
Obama has studied under Marxists, he has idolized communist icons, and cozied up to socialist leaders. Even with all of this background knowledge, is exceedingly creepy to hear him speak of a "New World Order."
(Read More: Obama Still Discretely Running Fast And Furious Program Despite Lost American Lives)
The President said in his speech on Tuesday:
"But whether people see what's happening in Ukraine, and Russia's aggression towards its neighbors in the manner in which it's financing and arming separatists; to what's happened in Syria — the devastation that Assad has wrought on his own people; to the failure in Iraq for Sunni and Shia and Kurd to compromise — although we're trying to see if we can put together a government that actually can function; to ongoing terrorist threats; to what's happening in Israel and Gaza — part of peoples' concern is just the sense that around the world the old order isn't holding and we're not quite yet to where we need to be in terms of a new order that's based on a different set of principles, that's based on a sense of common humanity, that's based on economies that work for all people."
(Read More: Obama Pushing UN To Enforce Worldwide Gun Control)
If you can decipher that rhetoric, it would appear as if he's calling for a "New World Order" based on the global crisis which HE helped to create. Maybe Obama isn't as stupid as he seems. Perhaps he sits idly by as the world burns because it furthers his communist/socialist agenda.
H/T: IJ Review