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Some of the results of this study have been previously reported in the form of abstracts at the 28th Annual Meeting of Associated Professional Sleep Societies, June 2014, Minneapolis, MN.
FUNDING/SUPPORT: This study was supported by the National Heart, Lung and Blood Institute [Grant K23HL079114] and National Institutes of Health (NIH) National Center for Research Resources [Grant UL1 RR024989]. Dr Hazen was supported by NIH [Grant P01 HL076491]. Mass spectrometry studies were performed on instruments housed within a core partially supported by an AB SCIEX Center of Innovation grant.
aSleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH
bDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
cDepartments of Biochemistry and Pathology, University of Vermont, Burlington, VT
dDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH
eDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, MetroHealth Medical Center, Cleveland, OH
fDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
gDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital and Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
hDepartment of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
∗CORRESPONDENCE TO: Reena Mehra, MD, Sleep Center, Neurologic Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
Copyright 2016, American College of Chest Physicians. All Rights Reserved.
Although existing research highlights the relationship of OSA and cardiovascular disease, the effect of OSA treatment on cardiovascular biomarkers remains unclear. We evaluated the effect of OSA treatment on oxidative stress/inflammation measures.
We conducted a parallel, randomized controlled trial in moderate to severe OSA (apnea-hypopnea index ≥ 15) patients to examine effects of 2-month CPAP vs sham-CPAP on the primary outcome of oxidative stress/inflammation (F2-isoprostanes: ng/mg) and myeloperoxidase: pmol/L) and secondary oxidative stress measures. Exploratory secondary analyses included vascular and systemic inflammation markers. Linear models adjusted for baseline values examined effect of CPAP on biomarker change (least squares means, 95% CI) including secondary stratified analyses examining CPAP adherence and degree of hypoxia.
Of 153 participants, 76 were randomized to CPAP and 77 to sham-CPAP. In an intent-to-treat analyses, no significant change was observed in the sham and CPAP groups respectively: F2-isoprostanes (−0.02 [−0.12 to 0.10] vs −0.08 [−0.18 to 0.03]) or myeloperoxidase (−3.33 [−17.02 to 10.37] vs −5.15 [−18.65 to 8.35]), nor other oxidative markers; findings that persisted in analyses stratified by adherence and hypoxia. Exploratory analyses revealed percentage reduction of soluble IL-6 receptor (ng/mL) levels (−0.04 [−0.08 to −0.01] vs 0.02 [−0.02 to 0.06], P = .019) and augmentation index (%) (−6.49 [−9.32 to −3.65] vs 0.44 [−2.22 to 3.10], P < .001) with CPAP compared with sham, respectively.
In moderate to severe OSA, 2-month CPAP vs sham did not reduce oxidative stress despite consideration of a broad range of measures, positive airway pressure adherence, and hypoxia burden. These findings suggest that nonoxidative stress pathways primarily modulate OSA-related cardiovascular consequences.
Trial Registration
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text:
Front Axle swap and other info
View Single Post
Crazy Canadian
Posts: n/a
Been Looking at that
I have been looking at that option. I have been looking at the BDS lift kit and the procomp lift kit. I was thinking of doing the mud truck thing but it is to expensive.
I would just be looking for a trail truck. I have heard though, that a lot of people that go to 35" + tire sizes end up breaking stuff on there front end. Although I havent heard of any one doing it with a lifty kit, just a load leveling kit. I guess that doesn't really upgrade the rest of the drivetrain, it just stresses out the stock components.
I guess I am wondering what your product includes that make's a six inch lift possable. What kind of difference in street handling to you get with a 6" lift and how badly to you void you factory warranty.

subset: commoncrawl


text:
balussery Overview
You can reach balussery from Bangalore by road in about using a cab upon driving using a cab.
balussery is a small and fast developing town located in the kozhikode district in the state of kerala, south india. the balussery block has an area of about 278.54 sq. km. there are mostly eight grama panchayats in the block, namely atholi, balussery, naduvannur, koorachundu, kottur, panangad, ulliyeri as well as unnikulam. the town has a mean elevation of 42 meters, i.e. 138 feet. average temperature in the region varies from 30 to 36 degree celsius in the summer and about as much as 24 to 25 degree celsius in the rainy season. the nearest railway station to balussery is koyilandy which is 17 km away. also, the calicut railway station is about 25 km away from the town. the state highway linking koyilandy and nilambur passes through balussery. moreover, karippur (calicut) is the nearest airport which is 40 km away. buses, of both private as well as public sectors, broadly cover the entire district. the kerala state road transport corporation (called k.s.r.t.c.) has a bus station and a garage at the mavoor road in the city of kozhikode along with an operating center at thamarasseri..


text:
Fake or Fortune returns for a fifth series, beginning with one of the most challenging cases the team has ever encountered. Can art detectives Philip Mould and Fiona Bruce prove that a painting of a man in a black cravat is one of the first pictures ever painted by celebrated and controversial British artist Lucian Freud, even though Freud himself denied painting it?
The film probes deeply into the ways in which Freud's own experiences and unconscious processes may have inspired his influential and persistently controversial ideas.
This pseudo-biographical movie depicts 5 years from 1885 on in the life of the Viennan psychologist Freud (1856-1939). At this time, most of his colleagues refuse to cure hysteric patients, because they believe they're just simulating to gain attention. But Freud learns to use hypnosis to find out the reasons for the psychosis. His main patient is a young woman who refuses to drink water and is plagued by always the same nightmare.


text:
Zurich University Hospital, Gastroenterology and Hepatology, Zurich, Switzerland
SESSION TITLE: Lung Transplantation Posters
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 30, 2013 at 01:30 PM - 02:30 PM
PURPOSE: Lung transplantation (LT) is performed in selected patients with non-malignant end-stage lung diseases. Gastrointestinal complications impact considerably on allograft and patient survival. Gastroparesis (GP) is a recognized complication of LT and contributes to reflux and aspiration. We routinely use domperidone (three times daily) to reduce GP and its consequences. The objective of this study was to assess the prevalence of radiological evidence GP on abdominal plain films (APF) obtained for unclear abdominal symptoms in lung transplant recipients (LTRs).
METHODS: Retrospective chart review with assessment of APF of all LTRs followed up January-March 2013. Number of APF were documented and radiological evidence of GP was documented. Descriptive statistics of patient characteristics with and without GP including level of bronchiolitis obliterans syndrome (BOS).
RESULTS: Of 204 LTRs in our cohort 34 (17%) had clear-cut radiological evidence for GP despite domperidone treatment (GP group). Mean age of GP group was 46 years and 50 years for LTRs without GP (non-PG group). Female to male ratio was 21:13 for the GP group. Diabetes mellitus was diagnosed and treated in 50% of GP and 23% of non-GP group. 19/34 patients had cystic fibrosis as underlying diagnosis. Final BOS and intestinal perforation analysis is pending. Median number of APF per patient was 6 during follow up.
CONCLUSIONS: Gastroparesis can be diagnosed on abdominal plain films in 17% of LTRs despite consequent domperidone treatment. Lung transplant recipients with gastroparesis were predominantly female, diabetic and had an underlying diagnosis of cystic fibrosis.
CLINICAL IMPLICATIONS: Certain domperidone-treated lung transplant recipients for example with diabetes and cystic fibrosis may have to adapt certain life-style and anti-reflux measures to reduce risk of aspiration and reduce symptoms of gastroparesis. Additional medication with prokinetic properties should be considered in these patients.
DISCLOSURE: The following authors have nothing to disclose: Henriette Heinrich, Macé Schuurmans
No Product/Research Disclosure Information
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text:
3565 Labore Rd, Vadnais Heights, MN 55110
Event Center Manager
Cindi Reuvers email@example.com
Assistant Event Coordinator
Justine Tuckner email@example.com
Ph (651) 482-1233
Fax (651) 482-0804
Also known as Jimmy's Conference and Catering, the events at our facility include weddings, anniversaries, retirement parties, banquets, benefits, meetings, dart tournaments, and off-site catering and bar service. We have a selection of room options for any size group from 10 - 500 people. Jimmy's Event Center is connected to Jimmy's Food and Drink, and next door to the Holiday Inn Express Hotel & Suites via covered walkway. Our beautiful garden, patio, and gazebo area are also included in your list of options. We have a wide range of in-house services that will satisfy any special request, so don't hesitate to ask us!
Gazebo & Garden Photos
Birthday Party...
"Cindi - Thanks for all your good work. Everything was so nice; the service & food were outstanding."
Thanks again - Dennis & Connie
Thanks for your help, Cindi! It's a pleasure to work with you, and I look forward to being at Jimmy's again for this annual event. You have a lovely venue and the staff is great!
Deb LaValle
Executive Assistant
Concrete Paving Association of Minnesota (CPAM)
White Bear Lake, MN 55110
"The thing that made Jimmy's the best was not the reasonable price for this area. It was not the delicious food that we received so many compliments on. It was not even their beautiful decorations. It was the event coordinator. Cindi was absolutely amazing. She met with us many times to do food tastings, look at decorations, and talk about everything related to our reception. When the table runners that we wanted were not in stock, she quickly got other samples from a different vendor and offered us the same price. We had cupcakes at our wedding and even though she was supposed to charge us a fee for them, she did not. In addition, we dropped off our place cards and a few other things the day before and she personally set them up for us. We were very happy that we had our reception at Jimmy's!"
Cindy B, TheKnott.com
"I just wanted to send my compliments to the staff at Jimmy's. My organization had a meeting there on 10/21/15, and Cindi and all of the staff there were a pleasure to work with organizing the meeting. I will gladly recommend to anyone looking to hold an event, whether large or small to use Jimmy's Catering and Conference Center. Thank you so much!!"
Jody Anderson
Administration Manager
Pathfinder Village-St. Croix
Owners Association, Inc.
Grooms Dinner...
"I wanted to send a note to say thank you so much to your staff for a fabulous evening for our Grooms dinner. The ladies who attended to us that evening were very friendly, attentive, and just awesome service! The food and everything else was great too!! Just wanted you to know that, so thank you again!"
Celebration of Life...
"Cindi, I just wanted to thank all of you for making our Celebration of Life so easy and flawless. It took so much stress off me to have everything go exactly as planned. Emilia was exceptional and so professional yet so friendly and approachable. The rest of the staff also did a great job. So many people came up to me and expressed how nice everything was. I would use your facility again and I would recommend it to others. Thank you all for a great job! -Nancy Huebl-
Wedding Reception….
What a wonderful experience we had at your Event Center. Our son had his wedding there and it was awesome. Justine was so helpful during the whole planning. The room looked stunning and everyone absolutely loved the food. So many compliments on how fast the rooms were transformed from wedding ceremony to reception. Everything was just perfect. Joan was such a great help. We would recommend Jimmy's to anyone that is looking for a place for an event.
Our heartfelt thanks to Justine and Joan and everyone that was involved. It was a beautiful day!
Mary Jo and Mike Reil
Halloween Party...


text: Payless Shoes : Buy One Get One 50% Off 2nd Item | 20% Off Plus Free Shipping BOGO50% + Free* Shipping Payless Coupons See Deal About this Deal Buy One Get One 50% Off 2nd Item 20% Off Entire Order Coupon Code "90005" Free standard ground shipping with a $30 minimum order Coupon Code "TULIP30" Flag this deal Edit deal What's the matter? Choose a reason Dead deal Duplicate Bad link Spam Inaccurate No value Alive again Comments (2) rockinnrolla Apr 01, 2013 This is a awesome sale!! Thanks for all the great codes. :) Reply Cancel Mishumoshu Apr 01, 2013 I love this offer with 50% discount. Prepare a shopping list. Reply Cancel Load More Comments


text:
Skip to comments.Iraqi PM Nouri Maliki: Russian [used] jets will turn tide
Posted on 06/26/2014 11:32:45 PM PDT by Freelance Warrior
Iraq's Prime Minister Nouri Maliki has told the BBC that he hopes jets from Russia and Belarus will turn the tide against rebels in the coming days.
He said that the process of buying US jets had been "long-winded" and that the militants' advance could have been avoided if air cover had been in place. "I'll be frank and say that we were deluded when we signed the contract [with the US]," Mr Maliki said. "We should have sought to buy other jet fighters like British, French and Russian to secure the air cover for our forces; if we had air cover we would have averted what had happened," he went on.
He said Iraq was acquiring second-hand jet fighters from Russia and Belarus "that should arrive in Iraq in two or three days".
(Excerpt) Read more at bbc.com ...
Nouri Maliki and Iran are Shiites. ISIS, al Qaeda, Saudi Arabia and Mr. Obama are Sunnis. Any questions?
Yes. Why a Sunni Muslim is the President of the USA?
It is all Bush's fault that we left Iraq under Obama before the country was united in anything but fear of a tyrant.
He won in the electoral college.
Poor leader makes all country pay dearly. But Obama has been elected twice!
It still means he had a not meagre number of votes.
It may wind up as Syrian and Russian forces fighting ISIS with the USA supplying ISIS with weapons and cash.
It's a very dangerous game we are playing at.
too Little Too Late-—These jets will fall into the hands of the ISIS.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.


text:
- 1the raised flat area beside the track at a train station, where you get on or off the train The man fell from the platform and onto the tracks. The train stopped at the platform. compare track for performers
- 2a flat surface raised above the level of the ground or floor, used by public speakers or performers so that the audience can see them synonym rostrum Coming onto the platform now is tonight's conductor, Marin Alsop. Representatives of both parties shared a platform (= they spoke at the same meeting). raised surface
- 3a raised level surface, for example one that equipment stands on or is operated from an oil/gas platform a launch platform (= for spacecraft ) a viewing platform with stunning views over the valley politics/opinions
- 4[usually singular] the aims of a political party and the things that they say they will do if they are elected to power They are campaigning on an anti-immigration platform. They fought the election on a platform of low taxes.
- 5an opportunity or a place for someone to express their opinions publicly or make progress in a particular area She used the newspaper column as a platform for her feminist views. computing
- 6the type of computer system or the software that is used an IBM platform a multimedia platform shoes
- 7a high thick sole of a shoe platform shoes
at train station
nounjump to other results
Check pronunciation: platform


text:
ChanelGold Toned Chanel Hammered Wide Huggie Clip On Earrings
Vintage Chanel huggie style earrings from Season 28, circa 1991. This timeless style is a versatile accessory in any jewelry collection. Wear with hair pulled back to show off the rich hue. Constructed of hammered gold toned metal.Wide, half hoop bar. Clip on backs.
Made in: France Color: Gold Content: Metal Condition: Pre-owned. This item is in good condition, particularly for a vintage piece. Light tarnish on clip levers. No other visible signs of wear and tear.
Measurements & Sizing
- Total Length: .5"
- Total Height: 1"
Returns & Shipping
Luxury Garage Sale guarantees that all items sold on our site are 100% authentic. All products we accept are inspected for brand-specific guidelines and are put through a rigorous authenticity test process.
Item #: 140680


text:
Posts Tagged 'valley counseling'
Do not be afraid with therapy
Some people are scared to tell their problem because they do not want other people to interfere in their personal matters. It is not right because we have to tell our problem to people who we trusted and ask their advices. If we still doubt and do not have trusted person, we can visit Tarzana Therapist because we can get the best friend there. We do not need to scare to do the therapy because it will make us better and feel free.
Usually, the therapy will use some tools and take a long time but everything will be good. We can say anything that we want to say and cry out if we think is needed. We only do a better treatment that makes our hearts glad. So, are you afraid to do the therapy? I think you too plain because you believe what people said about psychological therapy. Try it yourself.


text:
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- Tour enCORE House
- 2016-2017 Student Funding Available for Research, Scholarship, Travel and Student Projects
- Energy and Environment Student Internship and Job Opportunities
- Ohio State Scores Big in RecycleMania Competition
- Energy Experts in the Classroom
- Energy and Environment Student Design, Innovation and Business Plan Competitions
2016-2017 Student Funding Available for Research, Scholarship, Travel and Student Projects
The Ohio State University is dedicated to advancing education, research, and innovation related to energy, the environment, and sustainability. To further those goals, the Office of Energy and Environment is pleased to offer student funding in three areas:
- Research: for students interested in researching a particular energy, environment, and sustainability-related issue on or near campus. Open to all full-time, degree-seeking Ohio State students. Click here for the Research Application. Deadline to apply was October 16. Click here to read about the 2016-2017 Research Funding Winners.
- Scholarship: for students interested in studying or pursuing a career in energy, environment, and sustainability. Open to full-time, degree-seeking Ohio State undergraduates. Click here for the Scholarship Application. Deadline to apply was November 15. Click here to read about the 2016-2017 Scholarship Winners.
- Travel: for students interested in presenting the results of their research or scholarship at an academic conference, meeting, or symposium. Also for students interested in study-abroad. Open to all full-time, degree-seeking Ohio State students. Click here for the Travel Application. Applications are due 30 days prior to event. Click here to learn about previously funded student travel.
All available funding for the 2017 fiscal year has been disbursed. Funding for the next fiscal year will be announced late summer-early fall. We welcome you to watch our website for future funding opportunities. For questions about the Research, Scholarship, or Travel programs, email firstname.lastname@example.com.
The Office of Student Life offers funding for campus projects through the Coca-Cola Student Sustainability Grants. The deadline for the 2016-2017 academic year was October 16.
Details and past awardee examples
Contact: Carlos Lugo, Program Manager, Sustainability


text:
Member since 1/30/2014
- 1 total post
- 1 review
Reviews & Stories
From a Pleased Patient - Chesterfield, MO
The office staff is very professional and courteous. They are friendly and knowledgable about everything in their field. Carol, Cindy, and Michelle are the people I have interacted with the most, and they are a joy to see. I have absolutely no complaints and I am always excited to come in for my appointment. Great consideration is given to every client to provide for the most comfortable... READ MORE


text:
ZEN Rooms Huay Kaew Road
Just 4.8 mi (7.8 km) from the airport, ZEN Rooms Huay Kaew Road puts you just a 5-minute drive from Chiang Mai National Museum and Chiang Mai Zoo. After having fun at the outdoor pool, you can grab a bite to eat at the restaurant. There's also a fitness center, and rooms at this upscale hotel offer room service and free WiFi.


text:
The West was listening, all right. Washington, Bonn, Paris and London were receiving the message from Moscow loud and clear. However, they responded by putting the message in a file marked 'Fairly urgent but deal with later'.
In the United States, the Bush administration, in its last year, was tired and absorbed by the presidential election campaign; Bill Clinton saw domestic recovery as his top priority. In Europe, the energies of governments were taken up by the crisis over the Maastricht treaty and the Yugoslav wars. Across the West as a whole, economic recession sapped the will and narrowed the vision of governments which knew in their hearts that the future of Russian reform was still the world's biggest issue.
It is not deafness but delusion that is the charge to be levelled at Western governments. Delighted at the end of the Soviet threat, they basked in wishful thinking about what might emerge in its place. They have offered Western publics a sanitised, comforting picture of events: sure, Mr Yeltsin has enemies, economic reform is proving difficult, and ethnic conflicts are raging around the former Soviet Union; but things are not going that badly - the nice guys will pull through.
It is a measure of the Western leaders' sensitivity that, when a high-ranking American diplomat dared last month to challenge this interpretation, he was instantly dismissed. Richard Armitage, who co-ordinated US assistance to the former Soviet republics, gave a speech in Tennessee in which he compared Mr Yeltsin's vulnerability to that of Mikhail Gorbachev in the late Soviet period. 'I think he's at about the end of his usefulness,' he said.
For months, the West has been reluctant to acknowledge the truth that Russia is not progressing into the glorious uplands of democracy and prosperity, but is sliding into the mud of economic ruin, nationalist reaction and civil conflict. One reason is that such an acknowledgement could place serious strains on the Western alliance. It would raise the question, that everyone would like buried, of whether Russia is going to become a cantankerous neighbour again. That, in turn, would raise the questions of whether the West should revive its policy of containment of Russia, and extend its defensive umbrella over newly democratic Eastern Europe. These are issues that expose tensions at the heart of the Atlantic alliance: French suspicions of US leadership of the West; German fears of Russia again becoming the great enemy to the east; and everbody's desperation not to throw away the cherished 'peace dividend' from the end of the Cold War.
The other reason is that, if the depth of Russia's crisis is publicly admitted, the question arises as to whether the West has pursued fatally misguided policies in its attempt to assist reform in Moscow. Was it right to encourage a head- long dash to the market economy that seems to have brought nothing but hyperinflation, a collapse in production and social hardship? Should the West actually have given Russia all those tens of billions of dollars in aid that have been generously promised but mysteriously withheld?
Two points should be borne in mind. First, Japan alone has the capital funds on the scale Russia requires. But Japan has refused to take the lead, partly because it wants Russia to hand back the Kurile Islands occupied by the Soviet army in 1945, and partly because it sees its neighbour as an economic disaster that would devour aid like a black hole.
The second point, rarely appreciated in the West, is that although Mr Yeltsin and his government are labelled 'market reformers' and 'radicals', their efforts at turning Russia into a Western-style economy ground to a halt almost as soon as they started. What has taken place since the dissolution of the Soviet Union 15 months ago has not been the development of a capitalist system; instead, central control of the economy has collapsed into chaos, with tax evasion, smuggling and all manner of corruption. Former Communist bureaucrats in Moscow have pumped money into gigantic state enterprises that have little or no future.
The West could have done nothing to reverse this chain of events. It was set in motion by the fall of the Soviet Union and has continued because, for purely internal reasons, Russia has been heading towards disintegration.
Russia's crisis has been simplified in the West into a battle between democrats and conservatives, Mr Yeltsin and the former Communists in the parliament. These struggles are certainly going on, but they conceal a deeper process in which Moscow's control of the multiple autonomous republics and regions that make up Russia is under serious threat. Just as the Soviet state could not maintain its authority over republics such as the Baltic states, Ukraine and, indeed, Russia itself, so the new Russian state is losing its grip over regions as far flung as the Pacific seaboard, Siberia and Tatarstan.
What we are witnessing is the continuing fall-out from the collapse of a centralised empire, the Soviet Union. It is naive to think that the West has much ability to influence it. What the West can do, however, is make clear to the eventual victors of the power struggle in Moscow that it wants to see a responsible, restrained Russia that does not threaten its neighbours or fundamental Western interests. The primary challenge for the West is not to pursue the illusion of turning Russia into a Western-style society, but to ensure its own security.
(Photograph omitted)Reuse content


text:
Christmas meal menu card
- A4 Sheet Stardream Quartz Card (each sheet will give you 1 card)
- A4 Sheet Cristina Re Red Spots & Stripes Paper (each sheet will give you 6 strips )
- 10mm Black & Red Satin Ribbon
- Paper trimming & scoring method of choice
- Scissors
- UHU glue
- 1/8" round hole punch
- Pencil and ruler
Step 1
Lay the A4 sheetlandscape orientation and using preferred scoring method, crease the A4 Quartz card at 99mm and 198mm, creating 3 evenpanels.
Step 2
Print your Christmas lunch or dinner menu in column 1 and 3 and your christmas greeting in the centre column.
Step 3
Cut the Red Spots & Stripes Paper into strips along the long edge of the paper creating strips 35mm x 297mm. Cover the strips lightly but thoroughly in UHU glue. Place the strip along the bottom of the card pressing firmly to achieve maximum adhesion.
Step 4
Lay the card in a landscape orientation and with the pencil and ruler mark two holes 70mm from the top and 10mm from the edge of the card at either end of the sheet. Using the Hole Punch, punch out the two holes.
Step 5
Cut the Black and Red Satin Ribbon into 20cm lengths.
Step 6
Fold the flap the cards along each crease to create a triangular card. Thread a length of both black and red satin through the holes and tie a simple double knot. Trim the ribbons to a pleasing length.
More homemade Christmas cards you can make
- Swirly stars Christmas card
- Hanging bauble Christmas card
- Sparkling stars Christmas card
- Christmas table placecards
- Christmas table centrepiece decorations
- Texture and colour Christmas card
- Christmas tree card
- Creative bauble card
Related card tips
- Tips and tools for making handmade Christmas cards
- Christmas card etiquette
- Browse all Christmas ideas, activities and recipes


text:
Lucknow, Sept 8: In a bone-chilling incident, a man turned monster as he brutally murdered his daughter and drank her blood in Kanpur Dehat district of Uttar Pradesh.
According to reports, Girijesh Pal, a resident of Jamaura village in Sikandra Tehsil was aspiring to become a tantrik (occultist).
On Saturday, Sept 5 night, Girijesh reportedly took her nine-year-old daughter Khushi, outside his house and killed her by hitting hand pump on her head.
When blood started oozing out of her body, then the monster man collected the blood in a plate and started drinking it.
At the time of the incident, his wife had gone to a nearby temple along with her two sons-Aman and Ankit to celebrate Janmashtami festival.
Shell-shocked by her husband's horrible act, his wife raised an alarm and alerted her neighbours.
Locals beaten him and handed him over to the police.
OneIndia News


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The VMI Toyota Sienna with Northstar E360 conversion is the paramount wheelchair van conversion for caregivers, offering an incredibly-simplified, manual, in-floor ramp and flexible seating, which allows caregivers to sit next to the wheelchair user. Like VMI's full-power Access360 conversions, the Northstar E360 offers more interior space and headroom than any other caregiver-centric wheelchair-accessible vehicle, making it ideal for large wheelchair maneuverability.
VMI's patent-pending Northstar E360 conversion comes with an easy-to-use, manual in-floor ramp that requires no bending or lifting and little to no maintenance. The ramp is stowed under the floor, creating more interior room, a quieter ride and less dirt and debris in the interior.
Ramp has a wide usable area and an 800-pound weight capacity to accommodate large wheelchairs.
Ramp slides out from beneath the floor, permitting passengers to enter and exit without deploying the ramp.
Ramp is stored under the floor for increased safety.
Caregivers of any size or age can easily deploy and replace the ramp with little effort and no bending.
The VMI Toyota Sienna with Northstar Access360 conversion offers more interior space for a greater range of movement. With a floor 12 inches longer than any Toyota conversion on the market, the Northstar E360 allows complete rotation for almost any wheelchair without scraping or scratching interior panels.
The front-passenger floor is free of obstacles to accommodate wheelchairs of almost any size.
Front passenger seat can be removed to allow the caregiver to sit next to the wheelchair user.
Most wheelchairs can turn around 360 degrees inside the van for safe, forward-facing entry and exit.
Optional single flip-up mid-row seat matches OEM interior and provides multiple seating options.
The VMI Toyota Sienna with Northstar Access360 conversion offers industry-leading door and interior height to accommodate wheelchairs of nearly any size. With more headroom than other mobility vans, the Northstar E360 conversion ensures caregivers and their loved ones can enter and exit their vehicle with absolute ease.
Up to five additional inches of door height provide enough clearance for the tallest power chair users.
Industry-best interior height creates more headroom for tall wheelchair users and passengers.
Transport never felt so good. The VMI Toyota Sienna with Northstar Access360 conversion offers a pristine interior and pleasant ride for all of your passengers. The VMI design seamlessly integrates the interior and exterior conversion with the factory vehicle, increasing functionality and form.
Factory-quality styling and color-match tie together flooring, molding and finishes for pleasing aesthetics.
Engineered to minimize interior noise with extensive use of sound-deadening materials.
Our Northstar E360 wheelchair-accessible minivans have been designed for maximum durability and functionality. Every feature promotes ease of use and vehicle longevity at an economical price.
All VMI conversion floors are E-coated for optimal rust and corrosion prevention.
High ground clearance reduces scraping caused by speed bumps, crested pavement or dips.
Single flip-up mid-row seat matches OEM interior and provides multiple seating options.
Unique, rubberized, non-slip flooring that provides excellent traction for wheelchairs and reduces road noise.
Standard on Toyota Sienna and Chrysler Pacifica
Steps added below the front doors to facilitate safer and easier entry and exit at those seating positions.


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Entry requirements
Minimum of a lower second class honours degree (2:2) in any discipline, or equivalent. Counselling Concepts and Skills Development, or equivalent. All candidates are required to participate in a half-day selection workshop/interview. Disclosure required.
Months of entry
Course content
The programme reflects the ethos of the person-centered approach to counselling, with the aim of fostering academic, professional and personal development. It follows a modular structure delivered over three years. An essential component of the training is the work with clients in a placement supported by individual and group supervision. Personal therapy, away days and residential weekends are also a feature of the programme.
Programme Structure:
- Theory and Practice of Counselling 1 (Develops knowledge of counselling theory and research)
- Ethical and Professional Practice 1 (Demonstrates how theory works in practice)
- Personal and Professional Development 1 (Facilitates learning about self in the counselling process)
- Theory and Practice of Counselling 2 (Year 2 builds on the knowledge base of Year 1)
- Ethical and Professional Practice 2 (Combination of a practice placement working with clients)
- Personal and Professional Development 2 (Further development in personal and professional awareness)
- Research Dissertation (Develops an understanding and appreciation for practitioner research)
The course has British Association for Counselling and Psychotherapy (BACP) accreditation.
Qualification and course duration
Course contact details
- Name
- Postgraduate Admissions
- firstname.lastname@example.com
- Phone
- +44 (0)1244 511300
- Fax
- +44 (0)1244 513111


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Transmigrasi precisava de um novo design de logo e criou um concurso na 99designs.
Um vencedor foi selecionado entre 138 designs enviados por 41 designers freelancers.
Cineasten.de is a upcoming german movie and home-cinema community.
I need a logo for the website http://www.cineasten.de.
In Germany, the word "Cineast" describes a person, who loves cinema and good movies.
The font should be a bit classical and not a typical web 2.0 text.
But the icon should be modern and clear.
The colors should fit to the current design on http://www.cineasten.de
The text is "Cineasten.de", the format must be a vector graphic.
- clear icon, classical font
- text and icon should be linked in a way
- should fit into the design
- logo must also look good printed on a poster
- too many colours
Find out how a design contest works or learn more about our logo design services.


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• Severity Rating • Fix Information • Vulnerable Software Versions • SCAP Mappings
|Static code injection vulnerability in admin/admin_configuration.php in Monalbum 0.8.7 allows remote authenticated users to inject arbitrary PHP code into the conf/config.inc.php file via the (1) gadm_pass, (2) gadm_user, (3) gcfgHote, (4) gcfgPass, (5) gcfgUser, (6) gclassement_rep, (7) gcontour, (8) gfond, (9) ggd_version, (10) ghome, (11) ghor, (12) gimg_copyright, (13) glangage, (14) gmenu_visible, (15) gmini_hasard, (16) gordre_rep, (17) gpage, (18) gracine, (19) grech_inactive, (20) grep_mini, (21) grepertoire, (22) gsite, (23) gslide, (24) gtitre, (25) guse_copyright, (26) gversion, (27) gvert, or (28) gcfgBase parameter.
|Note: References are provided for the convenience of the reader to help distinguish between vulnerabilities. The list is not intended to be complete.
|Date Entry Created
|Disclaimer: The entry creation date may reflect when the CVE-ID was allocated or reserved, and does not necessarily indicate when this vulnerability was discovered, shared with the affected vendor, publicly disclosed, or updated in CVE.
|Phase (Legacy)
|Assigned (20070514)
|Votes (Legacy)
|Comments (Legacy)
|Proposed (Legacy)
|This is an entry on the CVE list, which standardizes names for security problems.
You can also search by reference using the CVE Reference Maps.
|For More Information: email@example.com


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238 Ketchikeniqua S-5,1983 84,OA National Chief Flap,OH
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Fraternal, Political, Organizations
- Source: eBay
- Sold Date: Mar 23, 2011
- Channel: Auction House
This is an Order Of The Arrow, OA, patch. The Order Of The Arrow, OA, is the Honor Camping Society Of
The Boy Scouts Of America, BSA, B.S.A., and this item was produced to be worn on the Scouting Uniform.
The Order Of The Arrow, OA, was Originally known as the Wimachtendienk, and was formed into Lodges
by Name and Number and Originally Met Nationally at Grand Meetings what we now Call NOACs .
OA 238 Ketchikeniqua S-5,1983 84,National Chief Flap,OH, Light Brown, LBR, Rolled Edge, R/E, Border, Bdr.On Flap.
Plastic Back, PB, Flap. Swiss Loom Embroidery. THIS FLAP PATCH IS CRISP, PERFECT !!
White, WHT, Lettering, " 83 Home National, Lodge Chief 84 ", Horitzontal, HOR, Stitched Center Of Top Banner, Sky In
Bottom Flap Portion, and Snow On Violet, VIO, Mountains. Red, RED, Lettering, " WWW ", Arrow Left, A. L., Horizontal,
HOR, Stitched Left Top Part Of Banner, Loin Cloth, Arm Band, and Stripes & Details In Hair Roach. Blue, BLU, Horizontal,
HOR, Stitched Right Top Part Of Banner. Black, BLK, Lettering, " Ketchikeniqua Lodge 238 ", Outlines & Details On Turtle,
and Indian Brave. Orange, ORG, Yellow, YEL, and Light Orange, LOR, Sun In Left Sky. Khaki, KHA, Lettering, " OA ", In
The Top Banner, Line Between Banner and Bottom Flap, Bank Of River or Lake, & Trails To Tipis, and Fleur de Leis,


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Official Website of the City of Milwaukee
CALL for Action (414) 286-CITY | Click for Action
Common Council
A major objective of this contest is to assist our college bound recent high school graduates in the Milwaukee area to better understand where their paths lead. We hope that this contest will help our youth appreciate the sacrifice that African-American men and women of our past have made, and recognize their duty to continue the legacy of freedom through their activism and vigilance.
Download the Freedom Scholarship Essay Contest Application
Read the rules, guidelines and submission information
Since taking office in 2008, Alderwoman Milele A. Coggs has sponsored or cosponsored hundreds of Common Council files. View Complete List
Residents can apply online to quickly and easily place their names in nomination for appointments to serve on city boards and commissions.
Alderwoman Coggs has been an early and strong voice in the city for increasing and expanding community access and involvement in the boards and commissions appointment process, and she encourages residents to get involved and consider submitting their name for consideration using the new options. "The public deserves a nomination system that is more accessible and transparent, and one that will include potential board and commission candidates from across the entire city," she said. "Residents who want to become more civically active and involved should take advantage of this new process."
To jump start the process of getting help, call the Metropolitan Milwaukee Fair Housing Council at 414-921-1090. If you need help avoiding foreclosure NOW, you can get FREE professional help from a nonprofit counselor who will help you establish a budget, understand the terms of your loan and talk with your lender. Go to www.milwaukeehousinghelp.org, www.findaforeclosurecounselor.org or www.hud.gov.
Community Prosecution
Unit Case Files program
Bronzeville/Martin Luther King Drive
Business Resource Seminar
Report Vandalism to
Vacant Buildings
City Hall
200 E. Wells Street
Room 205
Milwaukee, WI 53202
(414) 286-2221
Phone: (414) 286-2221
Fax: (414) 286-3456
Winter 2015
Winter 2013
Spring 2013
Fall 2011
Winter 2010
Spring 2010
Fall 2009
Winter 2009
A limited number of booklets can be obtained by contacting my assistant at 286-8640. You can also download and print your own version of the directory, or call 286-CITY to instantly be connected with any city service.
The City of Milwaukee Health Department strongly advises parents NOT to share a bed with their infant. This is based on an American Academy of Pediatrics 2005 Policy Statement that states that the "risk of SIDS has been shown to be reduced when the infant sleeps in the same room as the mother," but the AAP recommends that infants not share a bed with parents or anyone else, due to proven hazards. Click here to view a video that offers some advice on how to avoid the problems associated with "co-sleeping" with infants.
Design by City of Milwaukee


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MONKTON — Three landowners now stand between Vermont Gas Systems and the 164 property easements it needs to proceed with Phase I of the Addison County pipeline project — if, that is, the Public Service Board decides in Vermont Gas's favor when it issues a decision in its reexamination of the project's 2013 Certificate of Public Good.
The full text of this article is only available to online subscribers.
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Click here to learn more about our subscription options.
If you have a print subscription, you can now add an online subscription at no additional charge! Just email us with your name and mailing address to set it up.
ADDISON COUNTY — A Christmas Eve almost as warm as the night of the Fourth of July, the temperatures even higher in some parts of Vermont than those in the subtropics. Streets, rooftops, branches, fields and hills barren and snowless until the last few days of December.
Most people have been enjoying the unseasonably balmy weather, even if it seemed a little strange. One group that really welcomed the late start to winter were those Vermonters responsible for Addison County roads.
MIDDLEBURY — Officials at the ambulance service that operates in the Middlebury area are usually cool, calm and collected. It's important for them to impart a composed demeanor when handling emergency medical situations.
MONTPELIER — Gov. Peter Shumlin said he will quietly meet with stakeholders in the massive Middlebury rail bridges project in hopes of defusing, and settling, a growing dispute between the town and Vermont Agency of Transportation (VTrans) officials regarding the size and duration of the estimated $40 million construction plan.
MONTPELIER — Area school districts struggling to draft budgets that comply with the new per-pupil spending guidelines prescribed by Act 46 might get an 11th-hour reprieve. The Legislature next month will consider amendments to Act 46 that might relax — or postpone — the spending restrictions that are part of the new school governance consolidation law.
VERGENNES — The Addison Northwest Supervisory Union Act 46 Study Committee was set to meet on Dec. 30 to finish its final unification report, including proposed Articles of Agreement, thus setting the stage for a March 1 vote on whether to transform ANwSU into a Unified District under the governance of one board.
MIDDLEBURY — It was a little less than three years ago that the Middlebury Fire Department proudly unveiled its new headquarters on Seymour Street.
Now the department needs more volunteer firefighters to fill its station.
ALASKA — Sea kayaking in Prince William Sound, falling into the serene rhythm of oar strokes cutting the gentle water as we paddle by a rookery of hundreds of chattering black-legged kittiwakes on a cliff face iced with streaks of cream-colored excrement.
CORNWALL — Children attending Cornwall's Bingham Memorial School are surrounded by some of the county's most successful and renowned farms. But in this age of digital distractions and other competing interests, most of the kids hadn't given much thought to what the farms are producing — even though they and their families are likely regular consumers of the milk, cheese, apples and syrup made a veritable stone's throw away.
Subscribe to Online Edition
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Copyright 2011 Addison Independent | 58 Maple Street, Middlebury, Vt. 05753 | All Rights Reserved
Site Development by Surf New Media


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Supplying Model Makers since 1895
Telephone us on: 01508 549330
A fantastic folding tasks lamp that can be taken anywhere it's also wireless! With different light settings, Rechargeable with up to 8hrs usage at lowest setting.
An energy efficient LED Rechargeable lamp with Dimmer FeatureThis portable, compact lamp is ideal for reading, craft, hobby as well as office use. It features a dimmable task light as well as a useful smaller night lightLamp Features:• Dimmable LED task lighting & smaller night light• Portable & Rechargeable• Energy efficient – Low heat emission• Mini stand for desk use or hanging slot for night light• 2m USB cable for use through Computer/Laptop• Mains UK/EU Plug with USB slotSPECIFICATIONS
E-commerce by Divendo


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Pros: Family time, sitting down together for all meals
Cons: Wish the cruise was longer
Recommends Mariner of the Seas? Yes!
Category Ratings
Click table then swipe to view all columns.
Click table then swipe to view all columns.
|Ship Quality
|Absolutely beautiful
|Food and Dining
|Amazing food and service
|Cabin / Stateroom
|Stateroom was cleaned several times per day, it was immaculate
|Service and Staff
|We were treated like royalty
|Great shows, large variety. Super activities from swimming to ice skating to mini-golf to rock wall climbing
Port Ratings
Click table then swipe to view all columns.
Click table then swipe to view all columns.
|Puerto Vallarta, Mexico
Go to travel agency right outside the Port and pay $40pp for the greatest day of snorkeling, super boat ride with sandwiches and drinks included. The boat was "Bubu's Toy". They take you to a beautiful secluded cove in Yelapa for lunch and a horse back ride to the waterfall. (Horse was $20pp extra, but worth it. Best day ashore ever.
Don't Miss: Boat called "Bubu's Toy" for snorkeling and lunch in Yelapa
|Cabo San Lucas, Mexico
Take a water taxi to Club Cascadas and request a "Day pass". Beautiful pools with swim up bars, beach front restaurant
Don't Miss: Sea-dooing
|Mazatlan, Mexico
|A wasted day listening to time share info at El Cid, tiny beach area with lots of vendors that are relentless


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Sad that the shelter is the first home this town kitty has known! An animal lover had been feeding her but when she delivered 6 kittens who were sick we knew we had to get her. She is agreeable to being handled and can be petted, but would be best in an outdoor setting where she can be safe. She cannot be returned to her previous situation as someone has been killing the cats in that area with poison. We are very rescue-friendly and have transport assistance to the northeast!
This pet is now available for adoption to a good and loving home. If you have a lot of love to share with a best friend please adopt one of our wonderful pets. All pets are up to date on shots, have been dewormed, and vaccinated for bordetella.
To adopt please complete this online Adoption Form
Feel free to email or call the shelter at 606 768-9368 with any questions or concerns. Thank you for considering a pet in need.
Website: http://www.petfinder.com/shelters/KY109.html
Information about sponsoring dogs, rescuing and volunteering can be found there.
To adopt please complete this online Adoption Form
Please contact the shelter at 606-768-9368, or by emailing us at firstname.lastname@example.com with any questions or concerns and thank you for considering a pet in need.
Please sponsor me via PayPal: email@example.com
Full sponsorship for dogs or cats is $120, partial sponsorships welcome!
Please include a note with the name of the animal you are sponsoring.
Checks can be mailed to Menifee Co AS, PO Box 75, Frenchburg, KY 40316
Please put the animal's name on the memo line of the check or in the comments in PayPal.
Thank You!
Your message has been sent to Menifee County Animal Shelter.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


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Rock F. Jones
Rockwell F. Jones is the 16th and current president of Ohio Wesleyan University in Delaware, Ohio. He was formally inaugurated on October 10, 2008, although he served as president of the University beginning on July 1, 2008. Previously, he held the office of executive vice president and dean of advancement at Hendrix College in Conway, Arkansas. Jones also served as vice president for enrollment and dean of admission and financial aid, interim vice president for student affairs, and chaplain at Hendrix College, his alma mater. Jones holds a PhD in educational administration from the University of Texas at Austin, a master of divinity magna cum laude from the Duke University Divinity School, and a bachelor of arts with honors from Hendrix College, where he received the college's President's Medal, presented to the student who best exemplifies the school's highest ideals.[1][2]
- ^ "Rock Jones accepts head role at Ohio Wesleyan University". Log Cabin Democrat. 2007-12-18. Retrieved 2011-02-06.
- ^ "Ohio Wesleyan names 16th president". Columbus Business First. 2007-12-18. Retrieved 2011-02-06.


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Las Vegas Furniture Online carries the following products. Select a manufacturer below to view the lines and collections carried by this retailer:
Simmons Bedding Company is the maker of Beautyrest, Beautyrest Black, Natural Care, ComforPedic and Simmons Kids mattresses, among others. Simmons ... See Simmons models »
Stress-O-Pedic is one of the largest independent bedding manufactures on the West Coast. At Stress-O-Pedic, we employ innovative product design ... See Stress-O-Pedic models »
Sealy produces a broad range of innerspring and specialty mattresses and foundations through the Sealy, Sealy Posturepedic and Optimum brands ... See Sealy models »
Watch GoodBed's overview of the 2017 Stearns & Foster product line-up here: https://www.youtube.com/watch?v=7yMUT6HpRVsProduct ... See Stearns & Foster models »
Aireloom mattress designs conform to your body with their unique constructions, providing proper body balance and support, as well as ... See Aireloom models »
Embody by Sealy is a collection of progressive latex and memory foam mattresses that provide a healthy sleep surface under ... See Sealy Embody models »
Have you shopped for a mattress at Las Vegas Furniture Online? Write a Review!
Las Vegas Furniture Online is a furniture retailer that sells mattresses in addition to other types of home furnishings. Headquartered in Las Vegas, NV, Las Vegas Furniture Online carries a variety of mattress models from which to choose, including mattresses from Aireloom, Sealy, Simmons, Stearns & Foster and Stress-O-Pedic Mattress. Las Vegas Furniture Online has a home furnishings store in Nevada serving the metro area(s) of Las Vegas, NV / Northwest Arizona.
Las Vegas, NV / Northwest Arizona
Have an update or correction to our information about Las Vegas Furniture Online? If so, please take a moment to suggest an edit.


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Simmons' online Master of Public Health program, MPH@Simmons, is designed to give you the real-world skills you need to address health inequity on a local, national, and global scale. You'll learn core public health methodology, leadership, and advocacy skills needed to improve population health equity. No GRE required. Request Information.
Capella University offers an online Master's in Public Health (MPH) and Doctor of Public Health (DrPH). These programs are designed around NCHL outcome-based competencies and prepare you to solve real-world challenges while developing your leadership skills, all in an online learning environment. Request information to learn more about Capella's public health programs.
Benedictine University CEPH Accredited Online MPH Program. Choose to focus on Health Education & Promotion, Health Management & Policy, Emergency Preparedness, or Epidemiology and earn a graduate certificate along with your MPH at no added time or cost. Request information.
A master of public health, or MPH, focuses on the science of creating good health in the local community through education, research and promoting good health. As a public health professional, you will stress preventing illnesses and diseases from occurring in the first place through healthy practices. This is opposite from the medical model, which is to diagnose and treat illness and disease. Public health professionals play a critical role in preparing for emergencies and responding to them. With an MPH, you can focus your career in these areas: health education, biostatistics, environmental health, epidemiology, and health services administration.
Master of Public Health Salary
There are a wide variety of jobs available with an MPH, but these are the median salaries that you can expect in the field. Note that the top 10% can earn much more than this, and the bottom 10% much less:
- Epidemiologists: $61,300
- Health educators: $44,000
- Medical and health service managers: $80,000
- Behavioral health scientists: $68,000
- Biostatistician: $75,000
Master of Public Health Jobs and Careers
The public health field provides professionals with a great many opportunities to boost the health of the community, and the opportunities in the field are growing as there is more recognition on the importance of preventing illness and disease, rather than just treating them.
YouTube Feature
Why Public Health? Allison Martin
Some of the areas where you can focus your MPH career include:
- Health administration and community health
- Health education
- Health policy
- Environmental health
- Biostatistics
- Epidemiology
Master of Public Health Requirements
To obtain your master's in public health, you will need to have a 3.0 GPA from undergraduate work, and probably at least a year of work in the health field. Depending on which area of MPH you want to focus on, you will need to have had specific coursework completed. For example, if you are interested in epidemiology, you will need to have had calculus. If you are interested in biostatistics, you will need to have had 1.5 years of calculus, and semester of computer programming. During your MPH program, you will take classes in biostatistics, public health administration, epidemiology, environmental health, data management, and much more. See more about requirements for Masters in Public health.
Master of Public Health Scholarships
While it is true that more scholarships are available to undergraduate students, you still can qualify for substantial financial aid for your master of public health. Schools and programs that offer scholarship assistance include:
- Oregon Health and Science University
- Columbia University
- Washington University in St. Louis
- University of Pittsburgh
Read more about the Most Common Public Health Scholarships.


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Tata Institute of Fundamental Research, Homi Bhaba Road, Colaba, Mumbai 400005, India
Macquarie University, MQ Photonics Centre, Department of Physics and Astronomy, Sydney 2109, Australia
* Address all correspondence to: Sudipta Maiti, Tata Institute of Fundamental Research, Homi Bhaba Road, Colaba, Mumbai 400005, India. Tel: +91 2222782716; Fax: +91 2222804610; E-mail: email@example.com.
Instruments with single-molecule level detection capabilities can potentially benefit a wide variety of fields, including medical diagnostics. However, the size, cost, and complexity of such devices have prevented their widespread use outside sophisticated research laboratories. Fiber-only devices have recently been suggested as smaller and simpler alternatives, but thus far, they have lacked the resolution and sensitivity of a full-fledged system, and accurate alignment remains a critical requirement. Here we show that through-space reciprocal optical coupling between a fiber and a microscope objective, combined with wavelength division multiplexing in optical fibers, allows a drastic reduction of the size and complexity of such an instrument while retaining its resolution. We demonstrate a 4×4×18 cm3 sized fluorescence correlation spectrometer, which requires no alignment, can analyze kinetics at the single-molecule level, and has an optical resolution similar to that of much larger microscope based devices. The sensitivity can also be similar in principle, though in practice it is limited by the large background fluorescence of the commonly available optical fibers. We propose this as a portable and field deployable single molecule device with practical diagnostic applications.
Fluorescence correlation spectroscopy (FCS) is a powerful single-molecule level technique that can measure the hydrodynamic size of molecules and chemical kinetic rate constants.1- 2 Since the size of a fluorescent ligand changes when it attaches to an acceptor molecule, this technique has obvious possibilities in disease diagnostics, promising rapid and quantitative determination of binding and aggregation in the solution phase. Its high sensitivity and microscopic probe volumes imply that miniscule amounts (often in the femto-mole range) of sample and reagents are needed for an experiment. FCS hardware can also be easily adapted to make other types of fluorescence measurement simultaneously, such as the determination of fluorescence lifetime through Time Correlated Single Photon Counting. However, the spread of this technology beyond the optics laboratory has been hampered by the large size and cost of the available instruments. In addition, the complicated optical and electronic machinery of a typical FCS instrument lacks the robustness required for "out-of-the-laboratory" situations.
This scenario can completely change if an FCS instrument is designed such that it is compact and foldable, is impervious to misalignments, and is affordable, yet sensitive. The first step in this direction was taken when we introduced the fully fiber-optic FCS device.3 It used the same single-mode fiber for both excitation and collection of fluorescence. The tip of the fiber served both as a "focusing lens" and as the confocal aperture.4 However, the resolution and the sensitivity were poor due to the low numerical aperture (NA) of the single-mode fiber. While this is still useful for monitoring multiply-labeled objects such as protein aggregates,5 the device is impractical for single molecule detection. In addition, the instrument still required alignment of the excitation laser into the fiber, and of the fluorescence signal into the small aperture of the typical avalanche photodiode detector. Subsequent work by others, e.g., incorporating a microsphere lens at the end of the fiber,6 have now taken the sensitivity down to the single molecule levels. However, it is still not comparable in resolution and sensitivity to a full-frame instrument, which employs a high NA objective, and it still requires sensitive alignment of lasers and fluorescence beams into small apertures.
We present a strategy that combines a conventional high NA objective with the fiber scheme. It retains the compactness of the fiber scheme, yet promises resolution and sensitivity similar to that obtained from the full-frame devices. In addition, it uses fiber pigtailed lasers and fiber-based splitters/combiners incorporating specific wavelength-selective optics (i.e., wavelength division multiplexing), to eliminate any need of alignment.
In FCS, both the excitation and the emission paths need to be precisely defined, with respect to the optical axes of the instrument, and this is typically achieved through a series of lenses and mirrors. This approach adds bulk to the typical FCS instrument and makes it optically complex. However, any alternative scheme that proposes to make FCS alignment-free and robust must do so while satisfying these requirements.
There are two primary requirements for the excitation path. The laser beam has to be enlarged to an appropriate size in order to fill the back aperture of the objective lens (if high spatial resolution is required) and collimated. Furthermore, the collimated beam has to be steered along the optical axis of the microscope objective to the specimen.7 In the emission path, the back-propagating fluorescence beam has to be separated from the excitation beam by a dichroic filter and focused by a "tube lens" (which has a typical focal length of 15 to 20 cm) to a small confocal aperture (typically a few tens of micrometers) in front of the detector. This is typically achieved by moving either the aperture or the fluorescence spot in three dimensions (e.g., by moving the tube lens). A tube lens with a smaller focal length may reduce the size of the instrument, but that will also make the aperture size (required for confocality) proportionally smaller, demanding even more precise alignment.
In the scheme presented here [Fig. 1], we use a single mode fiber for carrying the excitation laser beam to the objective lens. The fiber is fixed connection (FC) connectorized, and a plate holding an FC receptacle (F1) is mounted at the base of a small rigid cage assembly. This assembly holds the fiber, a tube lens (L1), a microscope objective (O1), and a sample holder (S1). The fiber has a NA of 0.11 and a divergence of about 0.11 rad. The tube lens (L1, of focal length 3.5 cm) is placed 3.5 cm above the fiber tip, so that the excitation light is collimated after the lens and has a size of about 1 cm. Immediately above this lens, we mount a 1.2 NA water-immersion 60× objective (O1, Olympus, Japan, Model Number UPLSAPO). O1 focuses the light onto the specimen placed on a cover glass, which is mounted on another plate in the cage assembly (S1). S1 has a circular hole in the middle that allows the light to pass through and accommodates the nose-piece of the objective. The fiber at the other end is pigtailed to the source laser (Oz optics, Canada, Model Number OZ-2000–532-3.5/125-S-40–2 A-0.5–1 O-bl), eliminating any need for alignment there.
(a) Schematic of the set up showing the optical unit containing the objective (O1) and the tube lens (L1), and sample and fiber holder plates (S1 and F1, respectively). The figure also shows fiber-pigtailed laser source, fiber-multiplexing assembly containing dichroics and filters, the avalanche photodiode detector, the correlator, and the computer. (b) Actual photograph of the optical unit showing its size. (c) Details of the wavelength division multiplexer unit containing a dichroic (DM1), lenses to collimate the light beam at the dichroic (L1, L2, and L3), and a band-pass filter (F1) at the transmission port.
The fluorescence emission from the specimen is omni-directional, and given the reciprocal nature of light propagation, the portion collected by the objective lens is automatically focused back onto the tip of the excitation fiber. The small focal length of the tube lens helps to make the assembly small, but it does not create alignment issues. An actual photograph of this optical unit showing its size is shown in Fig. 1. The fiber tip acts as the confocal aperture, similar to the strategy employed earlier3 for limiting the observation volume. It is also similar to the approach used previously in fiber-based confocal microscopes.3,6,8- 13 The fiber is single mode for the emission wavelength, so the aperture size is optimal.
This fiber carries the fluorescence back towards the source laser. However, between the laser end and the objective end (OE) of the fiber, we place a small wavelength division multiplexer unit [detailed schematic in Fig. 1]. This contains a dichroic mirror (DM1) which reflects the excitation beam after it is collimated by a lens (L1). This collimated beam is further focused onto a fiber at the OE using a second lens (L2). The fluorescence from the sample is carried back through the same fiber onto the dichroic mirror (DM1), which transmits it toward the output port of the multiplexer and a lens (L3) focuses this onto a multimode fiber. A filter (F1) is placed before the multimode fiber for rejecting any remaining excitation light in the beam. This fiber carries the fluorescence to a fiber-coupled avalanche photodiode detector (SPCM-CD-2882, Perkin Elmer Optoelectronics, Canada). The whole fiber assembly is custom manufactured to our specifications by Oz Optics, Canada. The detector sends electrical outputs to a small USB connectorized processor card (Correlator.com, NJ, Model Number FLEX99OEM-12D) which interfaces with a small laptop computer and computes the autocorrelation function. The software for the acquisition and data-logging is written in-house using LabView (National Instruments, USA). A comparison of the current schematic with that of a conventional FCS set up is presented in Fig. 2. In a typical FCS set up, the optical path ABCDE from the laser source up to the dichroic mirror (DM1) involves four mirrors M1, M2, M3, M4 and two lenses L1 and L2 [Fig. 2]. In the fiber-based FCS system, this is replaced by the optical path A1B1 using a single mode fiber (SMF1) with a core diameter of 3.5 μm [Fig. 2]. In the conventional set up, the excitation beam expansion and collimation is performed using lens L1 and L2, before it reaches the objective lens (O1) which then focuses the excitation onto the sample [Fig. 2]. In the fiber-based system, a single wavelength division multiplexer unit (WDM) replaces this entire lens assembly. This has a dichroic mirror (DM1) and three lenses [see Fig. 1] integrated within combination with a single mode fiber (SMF2) and a lens L4 which is used to collimate the beam before O1 [Fig. 2]. In both the schemes, O1 focuses the excitation onto the sample, placed on a sample holder (S1). The fluorescence signal is collected back first through O1 and subsequently through the WDM unit [Fig. 2], whereas for the conventional FCS, L3 is used to collect back the fluorescence signal [Fig. 2]. The fiber coupler port P in a conventional set up, which consists of a three-dimensional translation stage, is replaced by a fixed fiber coupler port P1. In both the schemes, fluorescence signal is delivered to the avalanche photo-detector (APD), using a multi-mode fiber (MMF), and the detector output is further processed by the digital correlator card (COR) in a computer system (PC).
(a) Optical path for a conventional FCS set up: M1, M2, M3, and M4 are steering mirrors. L1 and L2 are biconvex lenses, which collimate the expanded excitation beam. DM1 is the dichroic mirror. O1 is the objective lens used to focus the beam onto the sample. L3 is the tube lens to focus the fluorescence signal in the fiber coupler port; P. MMF carries the signal to the APD, which is processed by the electronic card (COR) in a PC. (b) Optical path for a fiber FCS set up: A single mode fiber (SMF1) carries the excitation beam to the single WDM (which has a dichroic mirror (DM1). Another single mode fiber (SMF2) and a lens L4 is used to collimate the beam before the objective lens O1. L4 also serves as the tube lens to focus the fluorescence signal in the fiber coupler port, P1. MMF carries the signal from the WDM unit to the APD, which is processed by the digital correlation card in a PC.
We measured the diffusion time of rhodamine B dye in aqueous solution (at pH 7.0) at a concentration of 470 nM with this instrument. The concentration used here is higher than that usually used in FCS. However, this high concentration is needed in order to compete with the very high background fluorescence of the fiber. At this concentration, the specimen gives a photon count rate of 330 kHz, while the background is 90 kHz. The autocorrelation obtained from this solution is shown in Fig. 3 (open circles). The data is averaged for 10 min. The data fits to a diffusion time of 29 μs (grey line). Diffusion constant of rhodamine B in water is known to be 3.86×10−10 m2/sec.14 If we use this value for calibrating the probe volume (which is a measure of the resolution of the instrument), we obtain a probe volume radius of 215 nm.
Autocorrelation data (open circles) and a single component fit (gray solid line) obtained from a 470 nM rhodamine B solution. The corresponding residual plot is shown at the bottom (black).
The resolution obtained from the instrument is very similar to that of the commercially available FCS instruments. However, the sensitivity is much lower, and this is primarily due to the very high background fluorescence from the fiber. The background in principle can be much better in a fiber containing less fluorescent impurities. Also, if an excitation filter is added to the entrance port of the multiplexer unit and the length of the fiber between this unit and the objective lens end is kept to a minimum, much of this background fluorescence can be avoided, thus improving the sensitivity.
The most notable feature of the instrument is the size of the optical unit [Fig. 1]. At 4×4×18 cm3, it occupies about 1% of the volume of a typical FCS instrument. Other electronic units and the laser, etc., are also quite small and can easily fit inside a separate palm-sized box, which is connected to the optical unit through a single optical fiber. The other notable feature of the instrument is that the light path is fiber-based and foldable, and does not require any alignment [Fig. 1]. The only open part of the path is between the fiber and the objective, but alignment here is automatic, and is impervious to small changes in the relative positions of the optical elements. The instrument is therefore expected to be robust and field-deployable. We note that the instrument can be used for Photon Count Histogram and/or other modalities of fluorescence data analysis which demand single molecule level sensitivity. In addition, if a pulsed diode laser replaces the continuous wave laser and a high time resolution avalanche photodiode is used as a detector, fluorescence lifetime determination can also be performed simultaneously. We hope that this instrument will pave the way for making single molecule fluorescence technology available as a point-of-care clinical diagnostic tool.
Niraj Kumar Singh ; Jenu V. Chacko ; Varun K. A. Sreenivasan ; Suman Nag and Sudipta Maiti"Ultracompact alignment-free single molecule fluorescence device with a foldable light path", J. Biomed. Opt. 16(2), 025004 (February 25, 2011). ; http://dx.doi.org/10.1117/1.3548311
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text:
Decision makers
- Justice For Trayvon Martin
Rule Zimmerman as guilty.
Everyone is looking at this case in the form of blacks vs white. It has nothing to do with race ! He diliberately ignored what the operators told him, followed and killed a young black boy who didn't even have a chance to enjoy his future. If Zimmerman would have followed orders 2 strong parents wouldn't be mourning the death of their son. This case is being looked at from the wrong angle, we need to come together and make sure justice is served. Whether or not he is white , black, red , orange or whatever he killed a young innocent teen and had no right to do so. Lets not make another murderer walk free ! Lets get #JusticeForTrayvon
- Justice For Trayvon Martin
Rule Zimmerman as guilty.
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This brand new hotel offers fun, colour and entertainment for any traveller looking for the ambiance of authentic island charm combined with European sophistication. This hotel is perfect for groups, with 800 m� of meeting space, conference facilities and specially themed events throughout the resort. Built in 2009, this air-conditioned beach hotel houses a total of 237 guestrooms and welcomes guests in its lobby with 24-hour reception and check-out service, hotel safe, currency exchange facilities and lift access. Guests will find a newspaper stand and hairdressing salon, plus an auditorium and casino all at the establishment. Food and drink can be enjoyed at the caf�, bar, pub and restaurant. WLAN Internet access is available and both room and laundry services are provided.
The resort is located in the historic capital city of Willemstad, nestled in the historic setting of the Rif Fort.
The en suite rooms feature a shower, bath and hairdryer. A double or king-size bed features as standard, as does a direct dial telephone, satellite/cable TV, a radio and Internet access. There is a safe available for the storage of guests' valuables. Other features include a mmini-refrigerator, individually regulated air conditioning and a balcony or terrace.
The hotel has its own outdoor swimming pool, complete with sun loungers and parasols. Guests may also enjoy massage or spa treatment. Fans of the fairway can access a golf course in around a 20-minute drive. Sun loungers and parasols are also provided for use at the nearby sandy beach.
A continental buffet breakfast is served in the mornings and � la carte and set menu options at lunch and dinner time.
American Express, Diners Club, JCB, MasterCard and VISA credit cards are accepted methods of payment at this establishment.
Room Facilities:
Direct dial telephone
Satellite cable TV
Internet access
Mini fridge
Double bed
King size bed
Individual airconditioned
Wheelchair accessible


text:
I Sorry...I don't know how to use this! Tsunamis First off, a tsunami is
an unusual sea wave. It is caused by an seaquake
or and underground volcanic
Ride the wave! Tsunamis Ouch! Tsunamis leaves thousands homeless from the damages that it causes.
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Holiday Gift Guide 2010: BRUGO Mug Review and Giveaway (Ends 12/13) CLOSED
Wednesday, November 24, 2010 Posted by Dina N
I own about a dozen travel mugs and use one every day. My BRUGO mug is not just the best looking one in the bunch - although who can resist this beauty and its warm color, aptly called Passion? My BRUGO also makes sure I bypass the dangers of burning my mouth. And, to top it off, BRUGO never spills a drop. I can leave it lying flat on the seat next to me when driving, I can toss it in my purse or backpack - no spills, no mess. I have one word for you: leakproof!
BRUGO comes in a variety of beautiful colors. It holds 2 cups of coffee - exactly my morning dose of caffeine. In semi-tech speak, it has an ergonomic grip and double-wall insulation. Oh, and I can use it the old-fashioned way if I want to - sip without the tip-swish movement because the lid has three positions: lock (closed), tip & cool, and sip (with or without cooling).
BRUGO is hands down the best travel mug I've ever owned. My only problem with it is that everyone who sees it wants it! My family. My friends. My kids' teachers. Strangers in the coffee shop. Everyone wants a BRUGO! I tell them - don't ask Santa for one, just buy it for yourself and for that dozen of people who are on top of your holiday gift list. It's the perfect seasonal gift - the best $20 present you can get for anyone who drinks coffee, tea, or cocoa on the go. When ordering, remember to specify LEAKPROOF, because they have an older version that is not - although it does have all the other great BRUGO features.
Besides, BRUGO is always running promotions, and right now, I can get 25% off a purchase of two or more mugs, plus free shipping on orders over $50. And they ship worldwide!
The Giveaway
I know you want your own BRUGO! One lucky person will win a BRUGO travel mug.
To enter, please comment below with your favorite Brugo color.
You may do any and all of the following for extra chances to win:
- follow @BrugoMug on twitter;
- follow me on twitter and tweet about this giveaway, feel free to copy and paste: "Enter to #win an innovative @BrugoMug, great #holidays #gifts! #Giveaway open #worldwide ends 12/13 @aitmama #contests http://tiny.cc/yg2dl" – you may do this once a day;
- get 2 extra entries if you like BRUGO on Facebook - leave 2 separate comments;
- go here for additional ways to get extra entries.
Disclosure / Disclaimer: No monetary compensation was obtained for this post. I received complimentary product to facilitate this review. The opinions expressed here are mine and may differ from yours.


text:
|Stevie Wilson - Catherine Rigod and I both worked at Lucire.com as write...
Catherine Rigod
Chicago - United States
About Catherine Rigod
I am a writer and an independent thinker. Diverse in many areas of publishing and production, ranging from: copywriting on national and international advertising/marketing campaigns to creating beauty and fashion runway reviews, critiques and local events coverage.
I am looking for a fast paced and motivating environment, where I can grow in my copywriting and editorial skills. I am interested in all aspects of production from concepting to execution. I am extremely motivated and willing to take on a challenge anywhere the assignment may lead me.
Digital. Mobile. Apps. TV. Print. Radio. OOH. Social. Gaming. Promotions. Branding. Cross-channel integration. Digital Strategy. SEO., Client List, Kmart. Discover Card. Taco Bell. Motorola. Fisher-Price. Valspar. Homewood Suites. Hampton Inns. Canadian Club. Jim Beam. Harvey's Bristol Cream. Protege Shoes. Sony. Boeing. Beiersdorf. Cover Girl. Olay. Blue Shield of CA. KFC. Kraft. Bull's Eye. MilkPEP. SC Johnson.
If you notice offensive or incorrect information, please contact us.


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Singapore Uniquely Singapore Famous Faces Others Xie Jia Fa
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Xie Jia Fa Hot
Instagram 1053 6 0
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Listing created by Haziyah Ali on July 23, 2014
Xie Jia Fa is a DJ for one of Singapore's radio station; Y.E.S 93.3FM. He has been working under this radio station for 7 years.
He is also known as a host for variety shows and events like 'gala premieres'. Recently, he was the host for 'The Sheng Siong Show' and '12th Global Chinese Music Awards Ceremony'. He was also spotted hosting The Screen Singapore in 2012.
Additionally, Xie Jia Fa was casted in several local drama shows albeit as a 'cameo'. He was featured in Channel U's 'Marry Me' and Channel 8's 'The Legend Of Xiaoxiao'.
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Monday through Thursday: 9 am to 9 pmFriday and Saturday: 9 am to 5 pm.
East 11th Avenue is across Ritchie Highway from the Brooklyn Fire station. The library is next to Park Elementary School.
Work individually with a librarian and learn to access your library account, search the catalog and the Internet, navigate electronic databases and set up a free email account. Instruction in Microsoft Word may also be available.
Call 410-222-6260 for more information.


text:
This isn't just detox, it's M&S detox
Encouraging a fashion behemoth to change the way it produces clothing is no small task. But armed with the facts and the collective power of supporters like you, we are able to achieve the sort of success story we are announcing today.Which is that Marks & Spencer has committed to eliminate all releases of hazardous chemicals throughout its entire supply chain and products by 2020.As part of its commitment, M&S has taken an important step to phase out all perfluorocarbons (PFCs) by no later than 1 July 2016, acknowledging that the entire chemical group – which makes clothing stain and water resistant – is hazardous. As a significant user of PFCs, Marks and Spencer's move to eliminate this entire chemical group sends a clear message to the whole industry, including the chemical companies, that it's time to phase out this group of chemicals.Aside from the ban on PFCs, M&S has also reinforced a ban on APEOs (a family of chemicals, some of which are banned in the EU), and has pledged to set timelines to eliminate other priority hazardous chemicals.In addition to this, the company has promised to become more transparent about what its suppliers are dumping into our water and will start by releasing discharge data from five of their Chinese suppliers. This is an important pilot that they should look to expand to all facilities in the near future, as both the people living near the factories and the brands' consumers have a right-to-know what is being released into their water.What's next?M&S is now the seventh brand to make a credible commitment to clean up its supply chain and products and eliminate all releases of hazardous chemicals, joining Puma, Nike, Adidas, H&M, C&A and Li-Ning. More brands need to respond to the urgency of the situation and take ambitious action to rid the fashion world and our precious water supplies of toxic chemicals.The black list of 11 hazardous chemical groups that we ask brands to eliminate first is just the beginning. Work needs to be done checking all chemicals used in textile manufacturing, identifying hazardous ones and substituting them with safer alternatives, so their releases into the environment stop. This is a big task even with a deadline of 2020.We need action now. The textile industry is poisoning waterways around the world with hazardous, persistent and hormone-disrupting chemicals and treating our public waterways like private sewers. M&S has now shown other brands how quickly big brands can actually act. Let's demand brands to stop stalling and take the Detox challenge!
On the day of the 31st anniversary of the Chernobyl disaster, Greenpeace Russia activists on inflatable boats have rolled out a banner reading "No to floating Chernobyl" before the floating NPP "Akademik Lomonosov". They protested against the...
Right in the centre of St.Petersburg, Russia's second biggest city, Rosatom plans to fuel a floating NPP and start the reactor. Greenpeace collects signatures under the petition to the Governor Georgy Poltavchenko to stop hazardous works.
Greenpeace Russia has filed a request to the Head of the Federal Service for Ecological, Technological and Nuclear Supervision to check the legality of loading of nuclear fuel into the reactors of the floating nuclear power in St. Petersburg.
The Biodiversity Conservation Center (BCC) sent an urgent open letter to all prospective investors of the Shuren Hydro Plant in Mongolia, a project that seriously threatens Lake Baikal and the Selenga River, and will fail to get Mongolia the...
Today, people living in the basin of the Selenga river in Russia and Mongolia, together with a number of environmental NGOs, filed a petition at the World Bank Inspection Panel demanding that the feasibility studies of dangerous hydro-electric...
Gazprom's drilling rig GSP Saturn that was damaged in an Arctic storm returned to the port of Murmansk on November 19th. It had been stuck in the storm in the Pechora Sea for a week.
The towing of Gazprom's Arctic platform GSP Saturn, that was damaged in a storm on November 7, was interrupted due to severe weather. It is not clear when the platform will arrive in Murmansk and if the situation is safe.
According to several media reports, the Gazprom-Neft commissioned drilling rig GSP Saturn was damaged during a violent storm while being towed to Murmansk on Saturday November 8.
The UN World Conference on Indigenous Peoples started in New York, but several delegates that had a lot to tell were absent. Five Russian participants were held up by police and federal security agents and forcefully prevented from taking their...
Gazprom proceeds with its hazardous rush for offshore Arctic oil while failing to comply with Russian safety and environmental regulations, meanwhile its onland oil production remains a disaster for nature.
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text: I've activated the Random/Recent media block to show on the forum for XFMG, but nothing is showing other than a horizontal line that moves vertically (see screen shot) There are only embedded videos in the Gallery so could that be the problem or is there a setting I'm missing? I've tried this with both the custom style I'm using and the default style with no change. Thanks in advance for help.


text:
Fun on the Funship
Sail Date: September 22, 2012
Reviewed: 4 years ago
Traveled As: Couple
Room Type: Inside
Pros: Great entertainment and dance music
Cons: too many promotions--no TV due to satelite problems
Recommends Carnival Dream? Yes!
Category Ratings
Click table then swipe to view all columns.
Click table then swipe to view all columns.
|Ship Quality
|We found it to be clean and accessible. The elevators seemed slow. The plan is pretty easy to traverse.
|Food and Dining
|Something for everyone and if your original choice is not as expected\, the dining room team are quick to suggest something else.
|Cabin / Stateroom
|Service and Staff
|We found everyone very helpful and always ready to please.
|Production shows are excellent! Musical talent\, very entertaining. Comedy\, both family and adult\, most enjoyable. Music around the ship bars and lounges were excellent.


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