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The cause of lupus remains unknown, but there is solid evidence that genetics, epigenetics (changes in chromosomes that affect gene activity), environmental factors, viruses and infections play a role. Further study of these variables is expected to improve our understanding of causes, which should lead to improved diagnosis, prognosis, prevention, and treatment.
Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [8] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making it the cornerstone of SLE management. [104]
In SLE patients with serious brain (lupus cerebritis) or kidney disease (lupus nephritis), plasmapheresis is sometimes used to remove antibodies and other immune substances from the blood to suppress immunity. Plasmapheresis is a process of removing blood and passing the blood through a filtering machine, then returning the blood to the body with its antibodies removed. Rarely, people with SLE can develop seriously low platelet levels, thereby increasing the risk of excessive and spontaneous bleeding. Since the spleen is believed to be the major site of platelet destruction, surgical removal of the spleen is sometimes performed to improve platelet levels. Other treatments have included plasmapheresis and the use of male hormones.
Any of a group of glycoproteins with antiviral activity. The antiviral type I interferons (alpha and beta interferons) are produced by leukocytes and fibroblasts in response to invasion by a pathogen, particularly a virus. These interferons enable invaded cells to produce class I major histocompatibility complex surface antigens, increasing their ability to be recognized and killed by T lymphocytes. They also inhibit virus production within infected cells. Type I alpha interferon is used to treat condyloma acuminatum, chronic hepatitis B and C, and Kaposi's sarcoma. Type I beta interferon is used to treat multiple sclerosis. Type II gamma interferon is distinctly different from and less antiviral than the other interferons. It is a lymphokine, excreted primarily by CD8+ T cells and the helper T subset of CD4+ cells that stimulates several types of antigen-presenting cells, particularly macrophages, to release class II MHC antigens that enhance CD4+ activity. It is used to treat chronic granulomatous disease.
The prognosis for those with lupus often depends on the amount of organ involvement. In other words, is the disease targeting organs rather than skin and joints? Survival for lupus patients with central nervous system symptoms, major organ involvement, and/or kidney disease, is likely to be shorter than those with only skin and/or joint disease related to lupus. The most common cause of death associated with lupus is an infection due to immunosuppression, caused by medications used to manage the disease, especially early in the disease.
If you notice these symptoms or a combination of these symptoms and they can't be explained by another problem or illness you know you have, see your doctor to get them checked out. With early diagnosis and treatment, many of the symptoms of lupus and its complications can be managed, says Stuart D. Kaplan, MD, the chief of rheumatology at South Nassau Communities Hospital in Hewlett, New York.
Information on this website is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this website for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment. Any third party offering or advertising on this website does not constitute an endorsement by Andrew Weil, M.D. or Healthy Lifestyle Brands.
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Numerous studies suggest that moderate intake of alcohol may decrease the risks of developing cardiovascular disease problems, increase HDL good cholesterol levels, and may even decrease the risk for certain cancers. However, the sugar it contains will increase your calorie consumption (potentially contributing to weight gain) and regular alcohol consumption may increase the risk for breast cancer.
A one-celled organism without a true nucleus or cell organelles, belonging to the kingdom Procaryotae (Monera). The cytoplasm is surrounded by a rigid cell wall composed of carbohydrates and other chemicals that provide the basis for the Gram stain. Some bacteria produce a polysaccharide or polypeptide capsule, which inhibits phagocytosis by white blood cells. Bacteria synthesize DNA, RNA, and proteins, and they can reproduce independently but may need a host to provide food and a favorable environment. Millions of nonpathogenic bacteria live on human skin and mucous membranes; these are called normal flora. Bacteria that cause disease are called pathogens.
In studies conducted so far, African American patients and patients of African heritage did not appear to respond significantly to belimumab. An additional study of this patient population is planned to evaluate belimumab further in this subgroup of lupus patients. However, this difference in response to a treatment may be another indicator of the various ways that the disease affects different patients.
Do you think you may have lupus? If you have shown several of the signs for lupus, you and your physician may now take the next step in determining if it is lupus or another auto-immune disease. In order to make such a diagnosis, the individual must first show clinical evidence of a multi-symptom disease (i.e., the individual has shown abnormalities in several different organ systems).
I believe that we should ALL benefit from regularly working on stress relief! Take care of yourself by adopting stress-relieving strategies, such as exercise, meditation, yoga, art, or whatever works for you. The key is to choose something that you will enjoy and stick with. I personally use a heart rhythm pacer called InnerBalance, an app that coaches you to breathe in line with your heartbeat. Even giving yourself five minutes to sit quietly with a fragrant cup of herbal tea (caffeine-free, of course!) can work wonders for your adrenal glands.
Inflammation associated with lupus can cause stiffness, swelling, pain, and warmth of the joints, most commonly in the fingers, hands, elbows, ankles, and toes. (8) Most people with lupus will experience joint inflammation at some point, says Caricchio. For many people, joint pain is one of the first symptoms of the disease that they'll notice and report.
Moderate use of alcohol is usually not a problem for people with lupus, but alcohol can lower the effectiveness of some medications, cause new health problems, and/or can make existing problems worse. For example, non-steroidal anti-inflammatory drugs -- such as aspirin, ibuprofen (Motrin®), naproxen (Naprosyn®), and celecoxib (Celebrex®) -- can cause ulcers and bleeding in the stomach and intestines at any time during treatment; the chance of developing an ulcer or internal bleeding increases with alcohol use. Also, anticoagulant medicines such as warfarin (Coumadin®) and the chemotherapy drug, methotrexate, may not be as effective if you are drinking alcohol.
One food to avoid is alfalfa sprouts. Alfalfa tablets have been associated with lupus flares or a lupus-like syndrome that includes muscle pain, fatigue, abnormal blood test results, and kidney problems. These problems may be due to a reaction to an amino acid found in alfalfa sprouts and seeds. This amino acid can activate the immune system and increase inflammation in people with lupus. Garlic may also stimulate the immune system.
The NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases (2014) suggests that the symptoms may vary dependent on the type of lupus and the person. Symptoms tend to 'come and go', 'flare' from mild to severe intensity, and new symptoms of lupus can arise at any stage (NIH, 2014). Better Health Channel (n. d.) state that lupus may even become life-threatening, for example, should it damage major organs such as the kidneys or brain.
Fertility rates in women with systemic lupus erythematosus (SLE) may be similar to those in the general population. However, the incidence of spontaneous abortion, premature labor, early preeclampsia/eclampsia, fetal growth restriction, and intrauterine death are somewhat higher in women with SLE, [61, 138] especially in those with SSA(Ro)/SSB(La) antibodies, antiphospholipid antibodies, [88] or lupus nephritis. [139] One study suggested that women with SLE have fewer live births than the general population. [140] In this study, decreased live births were associated with exposure to cyclophosphamide and high SLE disease activity.
Saturated fats, on the other hand, can raise cholesterol levels and may contribute to inflammation. So they should be limited. Sources of saturated fats include fried foods, commercial baked goods, creamed soups and sauces, red meat, animal fat, processed meat products, and high-fat dairy foods. That includes whole milk, half and half, cheeses, butter, and ice cream.
While the genetics of SLE are not very well understood, there is growing evidence for the involvement of specific genes in this complex autoimmune disease. Part of the complexity of this disease is due to the effects of both environment and genetics factors that may contribute to its development.[49] Further compounding our understanding of the etiology of the disease is the involvement of several organ systems.[50] Genetic studies of the rates of disease in families supports the genetic basis of this disease with a heritability of >66%.[51] Identical (monozygotic) twins were found to share susceptibility to the disease at >35% rate compared to fraternal (dizygotic) twins and other full siblings who only showed a 2–5% concordance in shared inheritance.[51]
A group of people who review, approve, and monitor the clinical study protocol. Their role is to protect the rights and welfare of human research subjects participating in a study. The group typically includes people with varying backgrounds, including a community member, to make sure that research activities conducted by an organization are completely and adequately reviewed. Also known as an institutional review board (IRB) or ethics committee.
Below you will find that list, accompanied by questions created by the LFA to help individuals determine whether they should contact a healthcare professional to discuss the potential for having lupus. The LFA suggests discussing the possibility with a doctor if you answer "yes" to more than three of the questions, from your present and past health history.
Lupus is an autoimmune disease characterized by acute and chronic inflammation of various tissues of the body. Autoimmune diseases are illnesses that occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, such as bacteria and other foreign microbes. One of the ways that the immune system fights infections is by producing antibodies that bind to the microbes. People with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. These antibodies are referred to as autoantibodies.
Avoid calcium supplements, however, which Johns Hopkins researchers have found to potentially increase the risk of heart damage and arterial plaque buildup. "Due to the risk of accelerated atherosclerosis in lupus, we no longer recommend calcium supplementation and encourage a diet rich in calcium instead," noted George Stojan, MD, a rheumatologist and assistant professor of medicine at Johns Hopkins.
The immune response is how your body recognizes and defends itself against bacteria, viruses, and substances that appear foreign and harmful.The immune system protects the body from possibly harmful substances by recognizing and responding to antigens. Antigens are substances (usually proteins) on the surface of cells, viruses, fungi, or bacteria. Nonliving substances such as toxins, chemicals, drugs, and foreign particles (such as a splinter) can also be antigens. The immune system recognizes and destroys substances that contain antigens. Your own body's cells have proteins that are antigens. These include a group of antigens called HLA antigens. Your immune system learns to see these antigens as normal and usually does not react against them.
What are the causes and types of arthritis? Arthritis is a term that describes around 200 conditions that cause pain in the joints and the tissues surrounding the joints. The most common form of arthritis is osteoarthritis. Other related conditions include gout and fibromyalgia. The article looks at the types, causes, and treatments, including natural remedies. Read now
Lupus, a chronic autoimmune disorder that causes inflammation, creates a wide range of signs and symptoms. Systemic lupus erythematosus, the most common form of the condition, can potentially involve any major organ system of the body, says Neil Kramer, MD, co-medical director at the Institute for Rheumatic and Autoimmune Diseases at Overlook Medical Center in Summit, New Jersey. "Therefore, the first signs and symptoms vary from patient to patient."
Steroids Synthetic cortisone medications are some of the most effective treatments for reducing the swelling, warmth, pain, and tenderness associated with the inflammation of lupus. Cortisone usually works quickly to relieve these symptoms. However, cortisone can also cause many unwelcome side effects, so it is usually prescribed only when other medications—specifically NSAIDs and anti-malarials—are not sufficient enough to control lupus.
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Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.
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- 4 beds
- 2.5 baths
- $428,400 price
- 1002297424 mls id
- Half Baths: 1
- Square Feet: 2,584 sqft
- Year Built: 1971
This house was just rehabbed and it is gorgeous. Look at the room sizes - all large and comfortable. You will find refinished H/W floors throughout the house. The kitchen features new cabinets, granite counters, ceramic floors and backsplash, new stainless micro, refrig, DW and stove. This is a cook's delight! The kitchen and FR both have sliders that open to the brick patio, pool and play area. The large FR also features a beautiful marble framed FP. The master suite is huge and features a walk-in closet, 4 windows and an all new full bath with double sinks and ceramic floors and shower walls. The finished basement will add a massive amount of extra space for recreation. The pool table in the basement is included with the sale. The location is fabulous- only minutes from Route 70, 295 or Patco trains. This home is available for quick occupancy.
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4 beds, 2 baths, 2,154 sqft, $419,900
Courtesy of: Lichtman Associates Real Estate, LLC
Office Phone: +18567957890
Listing Agent: Sandra Lichtman
Updated: 20th February, 2019 1:17 AM.
34 SPRING MILL LN Cherry Hill, NJ


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Best Homecare Tips UJAT Caregiver Network News
A 5-Step Plan for Adopting Healthy Habits After 60
by UJAT Caregiver Network on February 19, 2019 at 8:38 am
Many people have trouble swapping unhealthy habits for healthy ones. It may be easy to start strong then fade away and eventually call it a failure. Or maybe it's hard to even get started. […]
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by UJAT Caregiver Network on February 17, 2019 at 3:30 pm
This past summer, my husband and I kept running into people who had been to Europe on bike trips. Every conversation fed our intrigue and we started looking into a self-guided bike trip through […]
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by UJAT Caregiver Network on February 17, 2019 at 3:15 pm
The music of my youth was more than melody and words. It was a kind of guidance into adult life, a soundtrack for thoughts and feelings that I didn't know how to reach on my own but were given […]
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by UJAT Caregiver Network on February 16, 2019 at 3:30 pm
How many blogs do you read in an average week? Have you ever wondered whether you should start a blog of your own? I can help you answer that question with a resounding, "Yes!" There are […]
The Battle Against Senior Loneliness: 5 Ways to Make New Habits That Keep You Engaged
by UJAT Caregiver Network on February 15, 2019 at 2:30 pm
Loneliness is a funny thing; it can sneak up on you when you least expect it. Have you found that you're not socializing as much at this point in your life? Maybe you've stepped away from […]
Make Stretching a Part of Your Daily Routine: Your Mature Body Will Thank You!
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Missed Opportunities Result in Close, 3-1 Loss at LoyolaFebruary 16, 2019
CHICAGO ? The Ball State men's volleyball team won the opening set and kept it close the entire night, but ultimately couldn't finish enough sets as it fell to Loyola, 3-1, on Saturday night.
Cardinals Can't Find Rhythm in 3-0 Loss at No. 10 LewisFebruary 15, 2019
ROMEOVILLE, Ill. ? The Ball State men's volleyball team struggled to generate much offense while Lewis had an incredible night blocking the BSU attack, and the Cardinals fell to the Flyers, 3-0, on Friday night.
No. 10 Lewis, No. 7 Loyola Await on Challenging MIVA Road TripFebruary 14, 2019
MUNCIE, Ind. ? The No. 12 Ball State men's volleyball team has faced seven ranked opponents this season, and will challenge two more this weekend as it travels to take on No. 10 Lewis and No. 7 Loyola in a tough pair of MIVA matchups on Friday and Saturday.
Ball State Edges No. 13 George Mason in Five-Set ThrillerFebruary 10, 2019
MUNCIE, Ind. ? On the brink of falling behind two sets to none while George Mason held a 24-20 lead in game two, the Ball State men's volleyball team fought off four-straight set points and came back to win the set, 29-27, while evening the match at 1-1. According to head coach Joel Walton, that was the break the Cardinals needed as they beat George mason, 3-2, in an exciting five-set match on Sunday night at Worthen Arena.
Cardinals' Winning Streak Snapped in Tough Loss to McKendreeFebruary 07, 2019
MUNCIE, Ind. ? Down a few players to injury and playing earlier in the week than usual after a long trip to the East Coast, the Ball State men's volleyball team took a tough loss to McKendree as the Bearcats came ready to play and swept the Cardinals, 3-0, on Thursday night at Worthen Arena.
MIVA foe McKendree, No. 13 George Mason set to Visit MuncieFebruary 06, 2019
MUNCIE, Ind. ? The No.11 Ball State men's volleyball team continues conference play on Thursday when McKendree comes to town, and then welcomes nationally ranked George Mason on Sunday for a battle of top-15 opponents.
Szews and Jenness Earn Player of the Week HonorsFebruary 05, 2019
MUNCIE, Ind. ? Junior outside attacker Matt Szews has been selected as the Midwest Intercollegiate Volleyball Association (MIVA) Defensive Player of the Week after helping the Ball State University men's volleyball team go 2-0 last week and push its winning streak to four matches.
Cardinals Take Care of Sacred Heart in 3-1 VictoryFebruary 02, 2019
FAIRFIELD, Conn. ? The Ball State University men's volleyball team played three solid sets of volleyball with one poor set in between as it defeated Sacred Heart by a score of 3-1 in an impressive victory on Saturday night.


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Robert Owen House is an eight-storey development in the heart of the city, as a solution to Glasgow's chronic lack of student housing.
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In response to the Nigerian government's failure to provide basic services like safe water, several insurgent groups have arisen to take matters into their own hands, writes Marcus DuBois King.
There is no clear and simple path toward a peaceful, prosperous, and democratic outcome in Venezuela, but here are a few guiding principles to start, writes Abe Lowenthal.
For the most part, the countries of Latin America are showing immense thoughtfulness and generosity in their responses to Venezuela's migration flow, but it is hard to know how long these open door policies will last, writes Andrew Selee.
Representative Adam Schiff recently discussed the new power dynamic in Washington and what's next for the Russia investigation.
The new Mexican government has to be realistic about what it can actually achieve, writes Luis Rubio.
Alexis Okeowo shares in her book a 21st century depiction of Uganda, Mauritania, Nigeria, and Somalia that is often difficult and disturbing—but also illuminating for practitioners in the international relations and conflict resolution fields, writes Kareena Kirlew.
Previous transitions from authoritarian rule toward democracy in other Latin American countries seemed impossible until they occurred, and that likely will be the case in Venezuela, writes Abraham Lowenthal and David Smilde.
Mexico has the opportunity for regime change, writes Pacific Council member Luis Rubio.
The U.S. needs a Senate-confirmed director of the U.S. Immigration and Customs Enforcement (ICE) in order to control immigration, argues Robert C. Bonner.
The core Republican Party principle in bringing power back to the states has disappeared in favor of a large and powerful federal government, argues Madison Jones McAleese.
Pacific Council member DJ Peterson shares his key takeaways from the 2018 midterm election.


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The Godfather Classic Quotes
Francis Ford Coppola's The Godfather is one of the greatest movies of all time and one of the most popular: on its 35th anniversary, it continues to be a top earner on video and DVD. But what has made this classic so compelling is the unique Corleone wit and wisdom. Every fan will want to own this officially licensed, completely fascinating anthology of memorable words from the film. It features a great selection of famous quotes from the "Family," from the Don's unforgettable "I'm gonna make him an offer he can't refuse" to Clemenza's infamous, "Leave the gun. Take the cannolis." Every sharp and witty line will bring back a memory of this great movie—and that makes it a perfect gift for every Godfather aficionado. Who would dare to resist?
TM and © 2007 Paramount Pictures. All rights reserved.
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Carlo DeVito is a notable publisher, editor, winemaker, and author of over a dozen books, including Mrs. Lee's Rose Garden and Inventing Scrooge. His books have been reviewed in The Wall Street Journal, The Christian Science Monitor, and other national newspapers. As an editor and publisher, Carlo has acquired, edited, and published such authors as Stephen Hawking, Malachy McCourt, John Edgar Wideman, Stanley Crouch, Dee Brown, Dan Rather, Arthur M. Schlesinger Jr., Eleanor Clift, Susie Bright, Jane Goodall, Philip Caputo, Julia Alvarez, Budd Schulberg, Haynes Johnson, Dr. Howard Shapiro, Bo Dietl, Thomas Hoving, Peter Kaminisky, and Penelope Hobhouse. Carlo and his wife own the highly acclaimed Hudson-Chatha Winery in Ghent, NY.
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The book is great. I don't think one movie ever produced so many great quotes as the Godfather. My only question with authenticity is the page containing Connie's wedding invitation. In 1945 New York City did not have 5 digit zip codes.


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Michael Shermer criticized mediums in Scientific American, saying, "mediums are unethical and dangerous: they prey on the emotions of the grieving. As grief counselors know, death is best faced head-on as a part of life." Shermer wrote that the human urge to seek connections between events that may form patterns meaningful for survival is a function of natural evolution, and called the alleged ability of mediums to talk to the dead "a well-known illusion of a meaningful pattern."[201]
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The words of these scientists convey the significance of the endocannabinoid system, first identified by Raphael Mechoulam in the mid-1990s and possibly one of the most important recent discoveries about the endogenous chemical transmitters involved in maintaining health. Endogenous (created naturally within the body) cannabinoids and their receptors are found not just in the brain but also in many organs as well as connective tissue, skin, glands, and immune cells. The list of CBD oil benefits and health concerns treatable by CBD is so long because these receptors are integral to so many bodily systems.
Heart pounding, palms sweating, mind racing and a sinking feeling that hyperventilating might occur—does this sound like a familiar experience before giving a presentation or speech at work? Most people experience some form of public speaking anxiety, which can create a wide range of unpleasant symptoms before and during a public speaking event. Studies have shown that taking CBD internally, such as using CBD oil, can mitigate these anxiety-inducing effects.
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Disclaimer: This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
One way I do get the benefits of CBD regularly is a teaspoon of this hemp-infused honey in my tea at night. It helps me wind down and get to sleep (and it's not just my imagination… it has a whopping 20 milligrams of hemp oil and its relaxing effects in one teaspoon). These hemp honey sticks from the same company are also great for travel and on the go.
For patients suffering from seizures, the legalization of cannabis would be a decisive turning point. Epilepsy makes you desperate. Seizures are painful, sometimes debilitating. And then there are the aftershocks: broken teeth, bruises and cuts, lost time, humiliation. People with epilepsy are often depressed, and have more than double the suicide rate of the population at large. Epilepsy is also associated with a syndrome known as Sudden Unexpected Death in Epilepsy, wherein a previously healthy person with epilepsy simply dies without warning or explanation. Grinding on without relief isn't an option, but getting help is enormously expensive. Research conducted by Charles Begley, a professor of public health at the University of Texas, found that epilepsy treatment costs between $8,500 and $11,000 per year. Real Scientific Hemp Oil is no less expensive than its pharmaceutical counterparts, with no assistance from insurance. A single three-gram vial costs $149, while a six-pack of 10-gram tubes can cost $1,999 (or $1,599 on sale). HempMedsPx suggests a "serving size" of 0.5 ml twice daily. Only when these drugs are recognized as such will insurance pick up the tab.
During my visit, Penny showed me how she administers Harper's CBD oils. We stood in her kitchen, where a window opened onto a vista of green grass and a wooden swing set out back. After carefully mixing and measuring Harper's oils, Penny poured the liquid into a jumbo-sized plastic syringe. "We put this all online," she told me, referring to the several YouTube videos she has made to help other parents administer hemp oil. Penny leaned down over her daughter to fit the tip of the syringe into her gastronomy tube, and I stood by silently. Harper looked at Penny, and Penny smiled back at her, and eased the plunger down.
The medical use of marijuana has brought some attention to the subject of using cannabis-derived products for health, but it's important to understand how CBD oil differs. We'll get into this more in a bit, but the key difference lies in the parts of the plant being used to make the product. For example, CBD oil is also different from hemp seed oil, since it is extracted not from the seed but from the flowers, leaves, and stalks of hemp.
CBD oil promotes more restful sleep, and, according to research, is a potential treatment for sleep disorders. Obviously, showing up at work in a well-rested state allows for higher levels of productivity, lowered stress and a greater sense of well-being overall. This benefit can be particularly useful for those with unusual, irregular or nighttime work schedules.
Whether you're purchasing CBD oil or CBD hemp oil for sale, remember that what is written on the bottle – the big 300mg – doesn't mean that the 300mg is packed with CBD only. It means that the whole bottle is 300mg. It's important to read the label. When calculating the actual CBD content, you'll want to remember that the following ground rules apply:
Kozela, E., Lev, N., Kaushansky, N., Eilam, R., Rimmerman, N., Levy, R., Vogel, Z. (2011, July 12). Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis?like disease in C57BL/6 mice. Retrieved January 17, 2018, from https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2011.01379.x
"When purchasing a CBD product, keep in mind that a transparent company's CBD milligram (mg) strength is reflective of the actual active CBD in that particular product," states Farias. "If a bottle says 250 mg of CBD, then that product should contain 250 mg of actual active CBD. However, a lot of companies currently in the market will list the mg dosage of their CBD hemp oil without publishing the strength of their actual active CBD."
CBD, or canabidiol is an amazingly useful plant compound that is extracted from the cannabis plant. With volumes of medical science now at its back, this compound has been used effectively for a wide range of needs. These particularly wide-ranging applications are the result of its being a part of the "pleiotropic sedate" group. Compounds in this group are especially unique in their ability to affect and travel along many of the typically closed atomic pathways.
Medical reviews published in 2017 and 2018 incorporating numerous clinical trials concluded that cannabidiol is an effective treatment for certain types of childhood epilepsy.[18][19] An orally administered cannabidiol solution (brand name Epidiolex) was approved by the US Food and Drug Administration in June 2018 as a treatment for two rare forms of childhood epilepsy, Lennox-Gastaut syndrome and Dravet syndrome.[11]
Oral CBD products with a ratio of 20:1 or higher and administered as drops, capsules, or edibles can be very effective in treating pain, especially the inflammatory type. Most discussions of treating pain with CBD suggest that finding the right dosage is critical. Always start with the micro dose to test sensitivity and go up as needed within the dosing range by body weight until symptoms subside. The micro to standard dose is usually recommended to treat pain, but patients need to carefully monitor their condition and experiment to find the right formula; 10–40 mg of CBD or CBD+THC together is usually enough.
Watch Out For: Companies who won't disclose their extraction method or utilize hydrocarbons like butane and propane. These substances are toxic in high amounts and even with proper purging, most hydrocarbon extracts contain residual solvent. Other extraction methods do not result in a full spectrum extract – meaning they were not able to extract all of the beneficial compounds from the hemp plant (i.e. you don't get the full range of benefits).
I have lower back pain with some arthritis and arthritis in my hands.ive recently tried CBD Oil. It really does work. I have the drops and ointment. They both work. Because of the back pain I never would have been able to go on a hike with my family. We had a lot of fun. And "No Pain", all day. I'm also Type 2 diabetic. Anxious to see what my A1C is next month. I'm a believer.
Many studies show that the majority of Americans feel long-term, work-related stress. This everyday, low-level anxiety many of us feel during the workweek can have long term effects on the body in the form of oxidative stress, which in turn is at least partially responsible for inflammation and many chronic diseases. Because CBD oil works to bring balance to the body by lowering anxiety and reducing stress-induced inflammation, it can be considered an effective aid in reducing anxiety, work-related stress and therefore oxidative stress.
As it is an anti-inflammatory, you may find CBD skin-care products helpful when applied topically. Some research even points to its efficacy as an acne treatment, since it may limit inflammation in the sebum-producing glands that can lead to breakouts. If you're not having luck with traditional acne-fighting ingredients (like salicylic acid), it may be worth giving it a shot.
[193] N. M. Kogan, E. Melamed, E. Wasserman, B. Raphael, A. Breuer, K. S. Stok, R. Sondergaard, A. V. Escudero, S. Baraghithy, M. Attar-Namdar, S. Friedlander-Barenboim, N. Mathavan, H. Isaksson, R. Mechoulam, R. Müller, A. Bajayo, Y. Gabet, and I. Bab, "Cannabidiol, A Major Nonpsychotropic Cannabis Constituent, Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts," Journal of Mineral and Bone Research 30, no. 10 (October 2015): 1905–1913.
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Cannabidiol (CBD) is one of the 100+ cannabinoids found in cannabis and has been the subject of much research due to its many and varied medical applications. But it's not only its therapeutic attributes that have sparked such widespread interest in CBD in recent years. The compound is also nonpsychoactive (meaning it does not produce the 'high' associated with cannabis use), making it a safe and effective option for patients who may be concerned about the mind altering effects of other cannabinoids such as THC.
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
Knowing how much CBD you're taking can take a little math. Again, capsules are straightforward—the bottle will say how much CBD each one contains. For tinctures, you need to know the total amount of CBD in the container and the container's size to calculate how much CBD is in each serving. I found 1-ounce tincture bottles, which contain roughly 30 servings, that ranged from containing 100 milligrams of CBD to 1,000.
Correct Answer: Organic ethanol wash – this is one of the oldest and most natural way to derive a full spectrum extract from the cannabis plant. A full spectrum extract strips all the beneficial cannabinoids and terpenes from the plant – in this case, without the need to use any heavy machinery or toxic hydrocarbons. The ethanol solvent is carefully boiled out to leave a CBD extract that is 100% safe and solvent-free. Full spectrum extracts utilize the whole plant which results in an extract with greater medical efficacy than isolating and administering CBD, for instance, on its own.
"For the relief of certain kinds of pain, I believe, there is no more useful medicine than Cannabis within our reach," wrote Sir John Russell Reynolds, neurologist, epilepsy research pioneer, and physician to Queen Victoria back in 1859.[382] In fact, cannabis was used for pain relief in all of the major ancient civilizations from Asia through the Middle East and into Europe and the Americas. The scientific inquiry into cannabis over the past several decades has confirmed that it is an effective and safe analgesic for many kinds of pain.
"The week before we tried it, we had 64 seizures," Penny told me, noting those were only the visible seizures, while unseen neurological events would likely push the number into the hundreds. "We administered hemp oil, and the next week we logged in 28 seizures. ... The very next week, her second week on the hemp oil, we logged none." Penny paused and repeated herself, as though she could still only half believe the miracle: "None."
Cannabinoid therapy is connected to the part of the biological matrix where body and brain meet. Since CBD (cannabidiol) and other compounds in cannabis are so similar to the chemicals created by our own bodies, they are integrated better than many synthetic drugs. According to Bradley E. Alger, a leading scientist in the study of endocannabinoids with a PhD from Harvard in experimental psychology, "With complex actions in our immune system, nervous system, and virtually all of the body's organs, the endocannabinoids are literally a bridge between body and mind. By understanding this system, we begin to see a mechanism that could connect brain activity and states of physical health and disease."[175]
However, at this point, research is still needed, and the surest way to avoid scams is to beware of those products that claim to cure everything. Maybe they do have beneficial properties, but playing with people's minds and hearts and with their desperate need to find a reliable treatment for painful conditions is not the right way to promote a product.
Dogs and cats are known for their powerful sense of smell. They typically don't like having something new added to their food, making supplementing their diets to ease health issues challenging. However, CBD products for pets take that challenge into account. Developed by dedicated veterinarians, they've been designed to pass the taste and smell test.
In 1992 Mechoulam's quest for quantification led him from the plant itself to the inner recesses of the human brain. That year he and several colleagues made an extraordinary discovery. They isolated the chemical made by the human body that binds to the same receptor in the brain that THC does. Mechoulam named it anandamide—from the Sanskrit for "supreme joy." (When asked why he didn't give it a Hebrew name, he replies, "Because in Hebrew there are not so many words for happiness. Jews don't like being happy.")
Today, dozens of companies produce CBD in an array of forms. CBD can be inhaled through vape pens, applied in topical salves, ingested in edibles, or swallowed in oil-based tinctures. Oil has become the dominant CBD delivery method for kids with epilepsy, since it is easy to administer and ingest, and there is no shortage of it available for sale online. There are dozens of companies boasting names like Healthy Hemp Oil, Dose of Nature, and Natural Organic Solutions, each of them selling CBD products at prices ranging from trivial to dizzyingly steep. You don't have to look hard to find them. If you have a PayPal account and $100 to spare, you could have a vial of hemp oil delivered to your doorstep.
I will continue to use bluebird botanical products loyally. Their customer service is exceptional. Their products are of exceptional quality and reasonably priced. Due to the dedication of their staff, I have been given back something I thought was lost to me: HOPE. I cannot thank BlueBird enough for their dedication to sharing a product that improves the quality of life for others.
Always start with the micro dose to test sensitivity and go up as needed within the dosing range before going to the next, until symptoms subside. The micro to standard dose is usually recommended to treat depression. Vaporized or smoked cannabis is recommended for relief of immediate symptoms, or a boost in dosage, and it can also be useful for sleep issues. Sublingual sprays or tinctures taken as liquid drops take effect quickly and last longer than inhaled products.
CBD is extracted from Industrial Hemp Plants that contain Cannabinoids. You cannot experience any psychoactive effects "High or Stoned" with our products. They all contain less that .3% THC or 0% THC. Every major civilization in history has recognized hemp as #1 on its list of important plants. The ancient Chinese, Indians, Egyptians, Assyrians, Persians, Greeks and Romans all revered hemp as an incomparable source of food and medicine. Now modern science is validating what the ancients all knew — and uncovering exciting new discoveries about CBD. Recently (August 2017) FDA has declared CBD as "beneficial" and is asking now all users of CBD products for their input.
Since then several other so-called endocannabinoids and their receptors have been discovered. Scientists have come to recognize that endocannabinoids interact with a specific neurological network—much the way that endorphins, serotonin, and dopamine do. Exercise, Mechoulam notes, has been shown to elevate endocannabinoid levels in the brain, and "this probably accounts for what jogging enthusiasts call runner's high." These compounds, he explains, apparently play an important role in such basic functions as memory, balance, movement, immune health, and neuroprotection.
While this is true to an extent, the simple fact of the matter remains that pure CBD oil with customer-backed therapeutic qualities is a rarity in the legal hemp marketplace. The vast majority of CBD oil online (even products that are extracted with CO2 technology and "verified" with third-party lab reports), is still subpar in terms of potency, purity, and therapeutic effectiveness.
CBD & THC are just 2 of many cannabiniods that will be seen on certificates of analysis; CBN for example is known to treat insomnia due to it's sedating qualities & the list of terpenes, is long & each one has it's own specific medicinal value. There's a tremendous amount of learning involved with finding the right CBD product as well as the individual doseage; it's advised for all beginners to "start slow & low".
Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now
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Medical Disclaimer: Statements in any video or written content on this site have not been evaluated by the FDA. If you are pregnant, nursing, taking medications, or have a medical condition, consult your physician before using this product. Representations regarding the efficacy and safety of CBD oil have not been evaluated by the Food and Drug Administration. The FDA only evaluates foods and drugs, not supplements like these products. These products are not intended to diagnose, prevent, treat, or cure any disease. The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any supplement program.
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Gelateria Valentino
Gelateria Valentino
A family business, Gelateria Valentino exists through the efforts of its ice-cream maker Jonathan Quarto and his parents, Valentino and Cecilia. They welcome and serve their customers wholeheartedly. The parlor is situated near the Fountain of Trevi, which makes it very accessible to tourists and locals. Gelateria Valentino is there to remind you to excuse neither food nor art, two of the essential features of the Italian capital.
via del Lavatore 96, Rome, Italy +39 066783219


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The sun is up and the stars are out at the Beverly Hilton for the 76th Golden Globe Awards.
Nominee Jim Carrey, hosts Sandra Oh and Andy Samberg, and Ryan Seacrest are among the stars hitting the red carpet early ahead of the ceremony's 5 p.m. start.
Click through our red carpet gallery now to see more familiar faces, and check back throughout the night to see all the latest entrances.
Michelle Yeoh had fans seeing green on Sunday's red carpet for the Golden Globes. The actress wore her now-famous "Crazy Rich Asians" engagement ring to the 76th annual ceremony.
Part of Yeoh's personal collection, the emerald-and-diamond ring played a pivotal role in the Golden Globe-nominated rom-com where it was introduced as Eleanor's (Yeoh) engagement ring.
Yeoh previously told The Times that she planned to wear the accessory because "the ring is so much a character in the film."
There's no better oracle for beauty trends at this year's Golden Globes than Charlotte Tilbury.
Dubbed the Queen of Glow and tasked with finessing Penelope Cruz's photogenic face for Sunday's 76th awards ceremony at the Beverly Hilton, the British makeup artist predicts a parade of glossy lips, enhanced with a glassy glow on the skin, on the red carpet.
"For me, this year is all about incredible, beautiful textures," Tilbury said in an email. (She spearheaded the makeup on the models in Peter Dundas' fashion show Saturday night and prepped Cruz, who is nominated for her supporting role in "The Assassination of Gianni Versace: American Crime Story," for the Globes on Sunday.) "Gorgeous, glowing, magic-goddess skin is never not on trend when it comes to the red carpet. But this year, for me, it is all about perfectly spa-cleansed, flawless, poreless, fresh skin."
From onstage at Saturday's Community Organized Relief Effort gala at the Wiltern in Los Angeles, host Sean Penn cited two cardinal rules of fundraising, starting with, "Don't bum out the crowd."
After ticking off the world's challenges, including Russia's hyper-sonic nuclear weapons, leaders who politicize the global economy, a rapidly changing climate, plus lies, greed, rage, sexism, racism and a drug epidemic, he said, "I know I've broken rule No. 1."
The two-time Oscar-winning actor, however, delivered on his second rule, that of creating "an encouragement of optimism and solutions — that we in this theater may participate in a shift to better days."
Awards season is kicking into high gear with Sunday's 76th Golden Globe Awards, and The Times is live and in person on the red carpet at the Beverly Hilton to report on all the latest behind-the-scenes action.
Follow @LATimesEnt on Twitter, @LATimes_Entertainment on Instagram as well as entertainment reporter Ashley Lee on Twitter at @cashleelee to see all the latest celebrity sightings, behind-the-scenes moments and much more.
So many guests at Saturday's star-studded BAFTA tea party at the Four Seasons Hotel Los Angeles crowded in to greet "Mary Poppins Returns" star and Golden Globes contender Emily Blunt and her husband, actor-writer-director John Krasinski, that a jam-up occurred in the doorway to the party venue. As the power couple inched into the room, Rob Marshall, director of Disney's "Mary Poppins Returns," closed in for a hug.
Nominee Regina King remained outside the ballroom for a while, avoiding the crush. Nominated for "If Beale Street Could Talk" and "Seven Seconds," the actress told us, "They're totally different roles … and yet they're similar because they both deal with women that are dealing with systemic issues in America.… I just feel lucky that they both happen to fall in the same year — as one shines light on the other."
Inside and outside the main ballroom, star power defined this shindig.
When Debra Messing approached the E! network on the red carpet at the Golden Globes last year, she had an agenda. It wasn't to wax rhapsodic about her "Will & Grace" costars or show off the black gown she was wearing.
She wanted to talk about the new organization she had joined, Time's Up. She wanted to express her belief in diversity and gender parity in the workplace. And she wanted to call out the very network she was appearing on for allegedly not paying its male and female hosts equally.
"I was so shocked to hear that E! doesn't believe in paying their female co-hosts the same as their male co-hosts," Messing said, referring to Catt Sadler, the anchor who had said a month prior she was quitting her job at the network due to an unfair pay gap.
At W's party Friday to celebrate the Golden Globes and the launch of the magazine's best performances portfolio insert, editor in chief Stefano Tonchi called Nicole Kidman "one of our great, great collaborators," given her appearance on so many covers over the years, including one of the seven for the upcoming issue.
A Golden Globe nominee for "Destroyer," in which Kidman is barely recognizable, the actress chatted with fellow guests with a sense of glamour that's a far cry from her look in the haunting film.
"I'm a mess," Kidman said with a laugh, referring to the guilt-ridden, disturbed police officer she plays. "I'm still carrying the weight on my back."
For the 76th Golden Globe Awards, even the trophy got a makeover.
The winners at the 2019 Golden Globes on Sunday will be handed trophies that are bigger, heavier and more ergonomically sound than those from last year.
This year's trophy has done away with the blocky marble base. The new cylindrical base, according to an announcement by the Hollywood Foreign Press Assn. on Friday, was designed "to ensure that winners do not obstruct the golden globe when holding the award."
Along with Sandra Oh, Andy Samberg hosts the Golden Globes for the first time this Sunday. However, the "Saturday Night Live" grad has emceed a major awards show before — the 2015 Emmys, to be precise. Ahead of Sunday's show, here's a look back at how he fared, according to our Times TV critic. This review was originally published Sept. 21, 2015.
Andy Samberg may have said he didn't care what the critics thought of his performance as host of this year's Emmys, but he oversaw a telecast that was a critic's dream. Fast-paced and mercifully uncluttered by too much "hostiness," the telecast mostly stayed out of its own way, with just enough jokes that didn't work to make us appreciate the ones that did.
Samberg opened with a musical number in which, having agreed to host the Emmys, he swears (in song) to watch every episode of every show. The overwhelming nature of this tasks entails locking himself in a bunker only to emerge one year later, tattered, unshaven and smelly.


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Actually,its just what i thought-good Review by Philippe
Not as comfortable. The right shoe is squeaky. Looks cool though. Review by Adam
Son loves the color Review by Anastasia
Perfect fit, I love them! Review by Ariel
Nice sneaker Review by Jovanny
Awsome shoes fit as expected and very comfortable Review by losquin
My son loves airmax:-) Review by Max
big fan of this shoe love them. Review by psykathy
Not really small but I have wide feet. Other than that they are great! Review by Gildas
Nice seller and product Review by parienty
the shoes fit as expected, but when I played in them the rubber soles really stick and twisted my knee somewhat.See if the loosen up with more time Review by Margery
Great shoe and rocking the chrome colorway. Review by Aline
I get a lot of head turners for this shoe. But to be honest, they kill my feet. You definitely cant wear them all day. MAX 2 hours. They are really hard to walk and ur feet hurts. They are definitely not comofortable AT ALL.... I wouldnt suggest anyone buy this unless you wear them just for 2 hours a day or you really dont mind being uncomfortable but like it when someone compliments you. Review by LOU
Arrived 10 days before the expected date.Great! Review by mastercard
These are absolutely beautiful! and at a great price! I will be using more colors for sure Review by Kamron
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Merkeze uzaklık
There was absolutely nothing to like.
The apartment was dark because there was no main lighting that was in operation (the main lamp was broken and propped up my weights). The bed was most uncomfortable with sheets that did fit properly. We had to request pillow slips for very old and dirty pillows. There was no room to store any articles as the cupboards were filled with other items. Our repeated requests to repair lighting went ignored. No one ever answered our calls. The worst place we have ever stayed in,
Beau petit studio situé au 17ème étage d'une tour avec vue sur la BNF. Très agréable. Calme. Accueil chaleureux. Bien situé, proche d'une station de métro.
Quelques équipements sont un peu vieillots (plomberie notamment)
Very good price for Paris within the city and easy walk to the Metro. The beds were perfect for one adult couple and a child.
The apartment needs some renovation and newer "equipment". It could also be cleaned a little more thoroughly.
Le studio très bien équipé et conforme à l'annonce est situé dans un quartier calme, près du métro et des commerces La literie est très confortable. nous retenons l'adresse et la conseillerons fortement .nous remercions le propriétaire, Monsieur AFIFI pour son accueil, sa gentillesse et sa grande disponibilité
Compact and convenient apartment in nice traditional Parisian building near metro station and all shops. Michel was right on time and very clear with all necessary information for check-in and check-out.
Not the owner's fault but the neighbour next door had two loud all-night parties in one week.
The location
Excellent location, close to attractions, great shops and metro
Great location and amenities. 2 blocks from metro station. Very helpful owner.
It's on the 5th floor lol
Helpfulness at check-in. We were confused about the location and our host helped us find it! Apartment is well equipped and in a good location. Everything was comfortable and clean and charming!
Location was excellent. Just a short walk to Notre Dame, the Seine, Pantheon and more. There was a grocery store next to the apartment and bakery across the street. I definitely recommend this location. Our contact person, Stephane was excellent in quick response to any questions or concerns we had. He took good care of us.
The furniture in the apartment was not very comfortable but adequate. The pictures are true, what you see is what you get.


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Weigh-Mart to Waymart
The only Delaware & Hudson Gravity Railroad depot left in Wayne County today houses the Waymart Area Historical Society. The exact age of the building is not known, but it is shown on an 1860 map.
The only Delaware & Hudson Gravity Railroad depot left in Wayne County today houses the Waymart Area Historical Society. The exact age of the building is not known, but it is shown on an 1860 map.
The start of a new year usually means it's time to move on from the past year's local government activities and early January re-organizational meetings. Also, there's been drama to keep up with over the partial federal government shutdown and the uncertain State of the Union address in Washington, D.C.
It's official: I have now lived in Sullivan County longer than I have lived anywhere else. Celebrating this happy milestone, I remember how forlorn but full of promise our derelict little house looked in 1997.
Over the recent holiday weekend, Sullivan County saw heavy snow, brought on by winter storm Harper. After accumulating nine inches of snow on Saturday and Sunday, Monday morning's temperature in Long Eddy was a -4 degrees F. Winter has surely arrived.
Of course, I'm referring to the epic ice storm that rained down on the Upper Delaware River region a few days ago, and not the Broadway play written by Eugene O'Neill in 1946. Yep, it's that time of year again, when I'm tempted to whine incessantly about the weather.
A primary muse and fellow poet whose spirit has walked countless miles with mine has gone silent. On January 17, Mary Oliver's battle with lymphoma came to an end.
A friend of mine recently turned me on to an interesting book by William Bridges, called "The Way of Transition: Embracing Life's Most Difficult Moments." Bridges, a well-known organizational consultant, author and speaker, has written several works on dealing with "transition" within organizations and careers, but this particular work is more a
While many of you are fans of winter and all things associated with it, I'm not that guy. Oh, sure—it can be picture-postcard-pretty here in the Upper Delaware River region, and I do enjoy taking photos in the winter wonderland, which helps the days pass.
In one of my 2018 "Narrowsburg News" columns, I solicited information from readers on a house in the Luxton Lake section of town. I had just bought the circa 1860s farmhouse, which was abandoned for many decades, and was starting the process of renovating it.
The great Gettysburg Reunion of 1913 marked the 50th anniversary of the crucial Civil War battle and the largest official gathering of veterans from both sides of the conflict. A total of 53,407 veterans, 8,750 of them Confederate, gathered peacefully from June 29 through July 4, 1913, with delegations from 46 of the 48 states.
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