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Plasma levels of interleukin-33 and soluble suppression of tumorigenicity 2 in patients with advanced pancreatic ductal adenocarcinoma undergoing systemic chemotherapy
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Interleukin-33 (IL-33) and its "decoy" receptor soluble ST2 (sST2) are involved in the development of chronic inflammation and cancer. We explored IL-33 and sST2 as a potential prognostic marker in patients with metastatic and locally advanced pancreatic ductal adenocarcinoma (PDAC). IL-33 and sST2 plasma levels were assessed in 20 patients with advanced PDAC before start of systemic chemotherapy and were analyzed in relation to clinical outcome. Kaplan Meier and multivariable Cox proportional hazards model analysis revealed a significant association between sST2 plasma levels and survival (HR 2.10, 95% CI 1.33–3.41, p = 0.002) and link high sST2 plasma levels to inferior survival in patients with advanced PDAC undergoing chemotherapy.
KeywordsIL-33 sST2 Cytokines Pancreatic ductal adenocarcinoma Chronic inflammation
Disease control rate
Eastern Cooperative Oncology Group
Hazard ratio
Interquartile range
- Nab-paclitaxel
Albumin-bound paclitaxel
- Nal-iri
Nanoliposomal irinotecan
Overall response rate
Overall survival
Pancreatic ductal adenocarcinoma
Progression free survival
- sST2
Soluble suppression of tumorigenicity 2
- Th
T helper
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a devastating 5-year overall survival of only ~ 7%. Although just 4% of all malignant diseases is accounted to PDAC, it will become the second leading cause of cancer-related deaths before 2030 [1]. A major cause for the aggressiveness and dismal prognosis of this malignant disease is the abundance of immune suppressive mechanisms displayed by PDAC, which is thought to support tumor growth and promote metastasis. The former perception of PDAC as a poorly immunogenic tumor has now been replaced by the notion of an inflamed tumor that evades the immune control by exerting immunosuppressive mechanisms in its microenvironment [2]. For this reason, kinetics of blood-based markers might be used to track the footprint that is left by the inflammatory response in patients with PDAC that reflects the current state of the tumor in terms of tumor growth and progression.
Interleukin-33 (IL-33) is a pro-inflammatory cytokine and it is involved in the development of chronic inflammation and cancer [3, 4, 5, 6]. It is negatively regulated by several mechanisms and sequestration by the "decoy" receptor soluble suppression of tumorigenicity 2 (sST2) is likely to be crucial in this process [7]. IL-33 is upregulated in PDAC and nonmalignant cells in the tumor microenvironment of PDAC and lesions from chronic pancreatitis: pancreatic stellate cells and pancreatic myofibroblasts have been identified as important sources of this cytokine [8, 9, 10].
Therefore, we assessed the plasma levels of IL-33 and sST2 by blood sampling in patients with PDAC before start of their systemic cytotoxic therapy to determine its role as a prognostic marker in PDAC.
Subjects and study design
This is a single center, retrospective, observational study including patients with histologically proven non-resectable PDAC that was either locally advanced or metastastic. Patients who started first line systemic cytotoxic chemotherapy with albumin-bound paclitaxel (nab-paclitaxel) or later line chemotherapy with nanoliposomal irinotecan (nal-iri) in combination with infusional 5-fluorouracil (5-FU)/leucovorin (LV) in the recruitment period between July 2016 and January 2017 were eligible for this study. The study endpoint was the clinical outcome as determined by efficacy endpoints such as overall survival (OS), objective response rate (ORR), progression free survival (PFS), and disease control rate (DCR). OS was calculated from the time of the start of the therapy until death from any cause. Survival times of patients still alive at the last follow-up visit (in February and March 2018) were considered as censored observations. PFS was calculated from the start of the therapy to disease progression or death from any cause. Again, survival times of patients without disease progression at the last follow-up visit were interpreted as censored observations. ORR was determined by the proportion of patients with an objective response and DCR was determined by the proportion of patients that had an objective response or a stable disease. Computer tomography as efficacy assessment according to RECIST 1.1 was performed at baseline and at week 12. The study was approved by the ethical committee of the Medical University of Vienna (EK 274/2011) and complies with the Declaration of Helsinki. All patients had to provide written informed consent before participating in this study.
Blood sampling
Blood sampling was performed into EDTA-containing tubes at day one of the first administration of the systemic chemotherapy regimen. Samples were processed within 4 h after collection by centrifugation at 1500 × g for 10 min. Plasma samples were then aliquoted and stored at − 80 °C until further use. Carbohydrate Antigen 19-9 (CA 19-9) concentrations was measured using Electro-chemiluminescence immunoassay (ECLIA) on cobas e analyzer (Roche Diagnostics, Mannheim, Germany).
IL-33 and sST2 measurement
Circulating levels of IL-33 were measured using the Human IL-33 DuoSet® ELISA (R&D Systems, Minneapolis, MN, USA) according to manufacturer's instructions (sensitivity 1.65 pg/ml), while circulating levels of sST2 were measured using the Human ST2/IL-1 R4 Duoset® ELISA (R&D Systems, Minneapolis, MN, USA) according to manufacturer's instructions (sensitivity 12.5 pg/ml) as described previously [11, 12, 13, 14].
Statistical analysis
Continuous data are given as median and interquartile range (IQR). Categorical variables are summarized as counts and percentages. The median follow-up time was calculated using the inverse Kaplan–Meier method [15]. Survival curves were estimated by the Kaplan–Meier method and compared using the Log-rank test. Univariate and multivariable Cox proportional hazards regression models were used to evaluate the unadjusted and treatment adjusted effects of IL-33 and sST2 plasma levels on overall survival. Due to their skew distributions, log2-transformed values were considered for statistical analyses. Therefore, estimated hazard ratios (HR) refer to a twofold change in the respective explanatory variable. To further explore the nature of the potential prognostic effect of IL-33 on overall survival, additional univariate and multivariable Cox regression models were performed, considering IL-33 as a binary factor (above versus below the detectable limit of 0.001 pg/ml) alone and combined with an additional continuous factor (including the log2-transformed IL-33 value for patients with IL-33 above the detection limit, and the value zero for patients with IL-33 below the detection limit). To reduce bias in estimates resulting from the small number of patients, the Firth correction was used [16]. The correlation of IL-33, sST2, and CA19-9 values is described by the Pearson correlation coefficient, and the partial Pearson correlation coefficient, respectively. The SAS software version 9.4 (SAS Institute Inc., 2016, Cary, NC, USA) was used for statistical analyses. P values < 0.05 were considered as statistically significant.
Baseline characteristics of patients
Ten male (50%) and ten female (50%) patients with advanced PDAC participated in this study (Table 1). The median age at time of diagnosis with advanced disease was 62 years (IQR 58–70 years). Fourteen patients (70%) had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 and six patients (30%) had an ECOG performance status of 1. In fourteen patients (70%), the CA19-9 levels were above 40 U/ml and in four patients (20%), the levels were below 40 U/ml. In two patients (10%), baseline CA19-9 levels were not available. Three patients (15%) had locally advanced (stage III) and 17 patients (85%) had metastatic (stage IV) disease. Liver (n = 10, 50%) was the predominant metastatic site followed by peritoneum (n = 5, 25%) and lung (n = 3, 15%). Three patients (15%) presented with additional distant lymph node metastasis. 13 patients (65%) had one and four patients (20%) had two different organs affected from metastatic spread. Half of the patients (n = 10, 50%) were therapy naïve and underwent first line systemic chemotherapy with gemcitabine and nab-paclitaxel, whereas the other half of the patients received nal-iri in combination with infusional 5-FU/LV and have previously progressed under a gemcitabine-based chemotherapy. Six patients (30%) had one previous treatment line and four patients (20%) already had two or more lines.
Baseline characteristics
10 (50)
10 (50)
Age at time of diagnosis (years, range)
62 (58–70)
ECOG performance status
14 (70)
6 (30)
Amount of CA19-9 at time of first blood sample
≥ 40 U/ml
14 (70)
< 40 U/ml
4 (20)
2 (10)
Disease stage
Metastatic (stage IV)
17 (85)
Locally advanced (stage III)
3 (15)
Site of metastatic lesions
10 (50)
5 (25)
3 (15)
3 (15)
Number of metastatic sites
3 (15)
13 (65)
4 (20)
Previous lines of systemic therapy
10 (50)
6 (30)
3 (15)
> 2
1 (5)
Administered chemotherapy
10 (50)
10 (50)
Clinical outcome
Among ten patients assigned to first line treatment gemcitabine/nab-paclitaxel, two patients (20%) had an objective response, three patients (30%) a stable disease, and five patients (50%) were progressing under systemic chemotherapy. The disease control rate (DCR) and overall response rate (ORR) in these patients were 50% and 20%. Median progression free survival (mPFS) was 6.5 months (95% CI 1.2—not estimable) and median overall survival (mOS) was 15.8 months (95% CI 1.2—not estimable). From the ten patients undergoing treatment with nal-iri/5-FU/LV, one patient (10%) had an objective response, four patients (40%) had a stable disease, and five patients (50%) were progressing. The DCR and ORR in these patients were 50% and 10%. MPFS and mOS was 3.1 months (95% CI 2.1–6.0) and 6.3 months (95% CI 2.8–10.2), respectively. Results are shown in Table 2.
Median overall survival, median progression-free survival, and response rates
Patients treated with gemcitabine/nab-paclitaxel (n = 10)
Patients treated with nal-iri/5-FU/LV (n = 10)
All patients (n = 20)
mPFS in months (95% CI)
6.5 (1.2–n.e.)
3.1 (2.1–6.7)
6.1 (2.8–7.4)
mOS in months (95% CI)
15.8 (1.2–n.e.)
6.4 (2.8–10.2)
7.8 (4.1–15.8)
Levels of IL-33 or sST2 and survival
Median plasma levels of IL-33 and sST2 for the entire cohort of patients were 6.8 pg/ml (IQR 0.0–33.6) and 13,064 pg/ml (IQR 6916–22,262), respectively. Median follow-up time was 18.2 months. Kaplan Meier analysis and Cox proportional hazards model revealed a significant association of IL-33 and sST2 plasma levels with OS.
Patients with plasma levels of IL-33 that were less than or equal to the median had a mOS of 4.3 months (95% CI 1.2–8.6), whereas patients with IL-33 plasma levels higher than the median had a mOS of 15.3 months (95% CI 6.1—not estimable, p = 0.01) (Fig. 1a). To adjust for a possible effect of first line versus later line chemotherapy, a Cox proportional hazards model was used. High IL-33 plasma levels were significantly associated with a superior survival in the univariate (HR 0.86, 95% CI 0.76–0.96, p = 0.008) and multivariable treatment adjusted model (HR 0.82, 95% CI 0.71–0.93, p = 0.002). Due to IL-33 plasma levels lower than the detectable limit in seven patients, we further aimed to analyze whether the survival differed in patients with IL-33 plasma levels lower versus above the detectable limit. Indeed, the binary factor (IL-33 plasma levels ≥ 0.001 vs. < 0.001 pg/ml) showed a statistical significant effect on the survival in the univariate (HR 0.19, 95% CI 0.07–0.57; p = 0.004) as well as the multivariable treatment adjusted model (HR 0.14, 95% CI 0.04–0.46; p = 0.001). However, there was no statistically significant difference in survival in patients with IL-33 plasma levels over the detectable limit in relation to the continuous levels (HR 0.93, 95% CI 0.76–1.18, p = 0.54).
Regarding sST2-plasma levels and survival, there was a statistical significant difference in survival for patients with plasma levels below or equal to the median with a mOS of 15.8 months (95% CI 6.1—not estimable) versus over the median with a mOS of 4.3 months (95% CI 1.2–7.1, p = 0.003) (Fig. 1b). This survival difference was confirmed in the univariate (HR 2.08, 95% CI 1.36–3.30, p = 0.001) and multivariable (HR 2.10, 95% CI 1.33–3.41, p = 0.002) treatment adjusted Cox proportional hazards model.
Correlation of IL-33, sST2, and CA19-9
To investigate a possible correlation of IL-33, sST2 plasma levels and the clinically well-established serum tumor marker CA19-9, the correlation coefficient was calculated by using the Pearson correlation. Plasma levels for IL-33, sST2, and serum levels for CA19-9 were correlated to each other. There was a moderate negative correlation of IL-33 and sST2 plasma levels (rho = − 0.449, p = 0.047). Neither plasma levels of IL-33 and sST2 correlated with serum levels of CA19-9. Results are shown in Table 3.
Correlation of plasma or serum levels of IL-33, sST2, and CA19-9
Correlation of plasma or serum levels of IL-33, sST2 and CA19-9
− 0.449 (0.047)
− 0.238 (0.342)
+ 0.263 (0.292)
This is the first study that evaluated circulating IL-33 and sST2 as a potential prognostic marker in patients with advanced PDAC.
There is increasing evidence that the IL-33/sST2 axis plays a crucial role in tumorigenesis and tumor progression in various malignancies such as colon, head and neck, breast, gastric, ovarian, lung, renal and pancreas [10, 17, 18, 19, 20, 21, 22, 23, 24, 25]. IL-33 has diverse context-dependent functions but originally it has been found that it mediates its biological effects via IL-1 family receptor transmembrane ST2 (ST2L) and activates NF-kB and MAP kinases. Its administration leads to significant increases in gene expression of prominent T helper (Th)2-associated cytokines IL-4, IL-5, and IL-13 in vivo in mice [26]. In PDAC, there is a strong imbalance between Th1 and Th2 response toward a Th2-type response and tumor infiltration with Th2-lymphocytes correlates with an increased expression pattern of Th2-related cytokines in the blood of PDAC patients [27, 28]. A predominant Th2-infiltrate in the tumor is an independent predictive marker of poor survival in PDAC patients [29]. To date, all studies except of one have linked increased serum levels of IL-33 and sST2 in cancer patients to negative prognosis [30, 31, 32, 33, 34, 35, 36]. For example, decreased survival has been demonstrated in non-small cell lung cancer patients with high serum levels of IL-33 and in hepatocellular carcinoma patients with high serum levels of sST2 [37, 38]. Our results support that high plasma levels of sST2 are also associated with inferior survival of PDAC patients undergoing systemic chemotherapy.
Regarding our results for IL-33, we found a significant negative effect of low IL-33 plasma levels on survival; however, in 35% of all patients, the measured IL-33 levels where below the detectable limit of the assay. Therefore, more caution to the interpretation of linking IL-33 plasma levels to survival has to be paid. If the patients are split up into two groups (IL-33 plasma levels < 0.001 vs. ≥ 0.001 pg/ml), we observed a statistically significant negative effect on survival in the univariate as well as in the multivariable treatment adjusted model. However, in the same model, there was no statistically significant difference in survival in patients with IL-33 plasma levels over the detectable limit in relation to the continuous levels (HR 0.93, 95% CI 0.76–1.18, p = 0.54) neither in the univariate nor in the multivariable model. Therefore, we found no statistical evidence suggesting that IL-33 plasma levels over the detectable limit have any effect on the survival in our patients. It must also be mentioned, that currently available IL-33 ELISA assays still lack the necessary reliability that would be needed for valid survival analysis [39]. In connection to that, we also just found a moderate negative correlation of IL-33 and sST2 levels. Recent studies have described pancreatic stellate cells and pancreatic myofibroblasts as sources of IL-33 production [8, 9]. As an intracellular cytokine, IL-33 is released after cell or tissue damage [40]. When released, IL-33 could enhance the expression of chemokines and cytokines in pancreatic myofibroblasts and stimulate the proliferation and migration of these cells, which further contributes to the pathogenesis of pancreatic desmoplasia, a hallmark of PDAC [8, 41, 42]. However, some studies also propose a possible protective role of the IL33/sST2 axis in melanoma, breast, colorectal, prostate and hepatocellular cancer tumor models by stimulating antitumor immunity [43, 44, 45, 46, 47, 48]. Therefore, further work is required to clarify the role of IL-33 in cancer.
The greatest limitations of our study are the small sample size, its retrospective character, and the current lack of a reliable IL-33 ELISA assay. If IL-33 is to be studied in the serum of patients, a more sensitive and specific assay method will be required, which is vital for further understanding and targeting of the IL-33/IL-1RL1 axis in human disease. This issue has been addressed in a recent study comparing currently available IL-33 ELISA assays [39]. With a larger patient cohort and a more reliable IL-33 assay, we would also not only expect to clarify the prognostic relevance of IL-33 plasma levels in PDAC patients but we could also divide patients into four different groups according to IL-33 and sST2 levels (IL-33low/sST2low, IL-33high/sST2low, IL-33low/sST2high, IL-33high/sST2high) to further elucidate the role of the relation between IL-33 and sST2 in malignant disease. However, it has to be highlighted that our data demonstrates a clear clue for the prognostic potential of sST2 levels for mortality prediction in our cohort and the statistical significance of the observed effect is also maintained in the treatment adjusted multivariable model.
In conclusion, we here report the first study that measured circulating IL-33 and sST2 in advanced PDAC patients that underwent systemic chemotherapy. Our results suggest a negative impact of high sST2 plasma levels on survival.
We would like to thank MSc Robert Brettner for the organizational and technical support in processing the blood samples.
Open access funding provided by Medical University of Vienna. This manuscript was supported by a Grant of the "Bürgermeisterfond der Stadt Wien" (Projectnumber: 15063).
Compliance with ethical standards
Conflict of interest
GWP has received Advisory Boards or Speaker fees from Celgene, Shire, and Halozyme. MK received travel support from Merck, Bayer, Bristol-Myers Squibb, and Roche and has participated in advisory board meetings from Bayer. All other authors declare no conflict of interest.
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any animal studies performed by any of the authors.
Informed consent
Informed consent was obtained from all individual participants included in the study.
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Ghatikia, Bhubaneswar 3,500 Per Sq.Ft. Dec - 2019
Alishan Infinia is one of the residential development of Alishan Consultancy, located in Bhubaneshwar. It offers spacious and skillfully designed 2 BHK and 3 BHK apartments. The project is well equipped with all modern amenities and 24 x 7 security service to facilitate the needs of the residents.
Plot No: N-1/210,
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Bhubaneswar, Odisha
Ghatikia, Bhubaneswar


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|Re: [Qemu-devel] fedora 7, cdrom and GPCMD_GET_EVENT_STATUS_NOTIFICATION
|Mon, 30 Jul 2007 00:21:27 -0500
|Thunderbird 126.96.36.199 (X11/20070615)
Matthew Kent wrote:
Been digging around for a solution or confirmation of this for a while now without much luck. Forgive me if there's a solution to this I'm just not seeing. Getting some ugly libata related errors in my guest like ata2: DRQ=1 with device error, dev_stat 0x49 ata2.00: exception Emask 0x0 SAct 0x0 SErr 0x0 action 0x2 frozen ata2.00: cmd a0/00:00:00:00:20/00:00:00:00:00/a0 tag 0 cdb 0x4a data 8 in res 41/50:03:00:00:20/00:00:00:00:00/a0 Emask 0x3 (HSM violation) ata2: soft resetting port ata2.00: configured for MWDMA2 ata2: EH complete when running a stock install of Fedora 7 (x86_64) in qemu (the stock fedora package of qemu 0.9.0 or kvm-33). Tried upgrading to the latest updated kernel 126.96.36.199-33.fc7, then the latest development one with no change. Tracked it down to hald-addon-storage which is polling the cdrom with SG_IO and GPCMD_GET_EVENT_STATUS_NOTIFICATION which is trying to "checkif eject button was pressed".In my search I found a brief example program in this ticket https://bugzilla.novell.com/show_bug.cgi?id=145147 which replicates the issue reliably here without involving hal. The workaround I found was to run hal-disable-polling --device /dev/scd0 but given the lack of success I had finding other people reporting this exact issue in libata proper, I'm guessing it might be something with the cd-rom emulation of which fixing is way over my head :) Guest dmesg and test case attached. Anyone else seeing this?
Yeah. I mentioned it on address@hidden I was forwarded to a link which mentioned the workaround you mentioned, as well as prefixing it with a 'killall hald-addon-storage'.
I also ran across this little patch, which I haven't bothered to try yet. http://bugs.debian.org/cgi-bin/bugreport.cgi?bug=431829 If you try it, let me know if it works. -dmc
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text:
[Expressions of interest should be received by 5 March] Wandsworth Council is seeking architectural services for the expansion of Hillbrook Primary School in south-west London
The contract is for feasibility study stage through to completion, and the £2.5 million project includes remodelling the existing school and an extension.
Evidence of previous experience working on similar schemes is required. The contract is due to be completed by 11 August 2014.
Relevant deadlines:
Expressions of interest should be received by 5 March
Client contact details:
Wandsworth Borough Council
Children's Services Department, 4th Floor,
Town Hall Extension
Ms. Marie Clarke
SW18 2PU London
United Kingdom
Telephone:+44 2088718511
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WALNUTS for POWER: Polyphenols, Omega-3 Fatty Acids, Weight Loss, and EneRgy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT03824652
Recruitment Status : Not yet recruiting
First Posted : January 31, 2019
Last Update Posted : January 31, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Prostate Cancer
|Other: walnuts Other: usual diet Other: phone counseling with dietitian
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|50 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|WALNUTS for POWER: Polyphenols, Omega-3 Fatty Acids, Weight Loss, and EneRgy
|Estimated Study Start Date :
|February 2019
|Estimated Primary Completion Date :
|January 2022
|Estimated Study Completion Date :
|January 2023
Experimental: Usual Diet + Walnuts
Usual diet with the addition of two ounces of walnuts daily, phone counseling with dietitian, for 6-10 weeks
Other: walnuts
2 ounces of walnuts daily for 6-10 weeks
Other: usual diet
Subject continues usual diet
Other: phone counseling with dietitian
Weekly calls with dietitian
Active Comparator: Usual Diet
Usual diet for 6-10 weeks
Other: usual diet
Subject continues usual diet
- Mean difference in prostatic tissue Ki67 expression from baseline biopsy to RP [ Time Frame: 10 weeks ]
- Mean difference in prostatic tissue oxidative stress from baseline biopsy to RP [ Time Frame: 10 weeks ]Measured by prostate tissue 8-hydroxy-2-deoxyguanosine
- Mean difference in prostatic tissue inflammation from baseline biopsy to RP [ Time Frame: 10 weeks ]Measured by 8-hydroxy-2-deoxyguanosine and immune cell infiltration
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Pathologically confirmed prostate adenocarcinoma with biopsy tissue available for analysis.
- Diagnostic biopsy cores with ≥10 cores with each core examined separately to determine exact tumor location.
- Biopsy grade group 2 or higher (Gleason ≥7).
- Scheduled to undergo RP.
- Willing to adhere to a usual diet with the possible addition of 2 oz of walnuts per day.
- Reads, writes, and understands English and has access to a computer or a Smartphone to complete ASA24 food diary.
Exclusion Criteria:
- Allergy to walnuts.
- History of receiving hormone therapy or antiandrogen therapy.
- Use of 5-alpha reductase inhibitors in the past 6 months.
- Prior prostate radiotherapy (external beam or brachytherapy) or prior prostate cryotherapy.
- Currently enrolled in a modified diet/weight loss program and/or taking dietary supplements that contain omega-3s (e.g., fish oil).
- Other active malignancy.
- Significant co-morbidities (e.g., cardiac, pulmonary, liver disease, alcohol/drug addiction, malabsorption syndromes), that in the opinion of the study physician make the patient ineligible.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03824652
|Contact: Dana Levin, MPH
|Contact: Laura Lockshon
|United States, California
|Cedars-Sinai Medical Center
|Los Angeles, California, United States, 90048
|Principal Investigator:
|Stephen Freedland, MD
|Cedars-Sinai Medical Center
|Responsible Party:
|Stephen Freedland, Professor, Surgery, Cedars-Sinai Medical Center
|ClinicalTrials.gov Identifier:
|NCT03824652 History of Changes
|Other Study ID Numbers:
|First Posted:
|January 31, 2019 Key Record Dates
|Last Update Posted:
|January 31, 2019
|Last Verified:
|January 2019
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Keywords provided by Stephen Freedland, Cedars-Sinai Medical Center:
prostate cancer
prostate adenocarcinoma
radical prostatectomy
omega-3 fatty acids
Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Prostatic Diseases
Weight Loss
Genital Diseases, Male
Body Weight Changes
Body Weight
Signs and Symptoms


text:
Migrations to the cloud entail risks with potentially vigorous impact on businesses - downtime and loss of data being top concerns. But with cloud adoption on the rise across industries... read more →
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Loss of a Credit Suisse Asia Hand
With the death of Paul Calello, Credit Suisse Group has lost not just its former head of investment banking but also a long-time Asia hand who did much to beef up his bank's standing in the region.
Mr. Calello, who died in New York at the age of 49, had worked in Hong Kong for five of the 20 years he was at Credit Suisse. In 2002, he moved to Hong Kong as head of Credit Suisse Asia-Pacific. He was promoted in 2007 to lead the bank's global investment-banking operations, underscoring the region's growing importance to the bank during his five-year stint in Hong Kong.
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Make this Memorial Day the most memorable yet, with an unforgettable kick-off to the summer season. A glamping getaway makes a splash and will be a vacation filled with memories for a lifetime. This year, whether you're staying home or traveling, consider a glamping trip and take advantage of the warm weather. With unbeatable outdoor locations, five-star amenities, and unique experiences, these glamping accommodations can't be beaten. So whether it's a staycation or you're hoping in the car, consider a trip to Texas Hill Country. Browse through these stunning accommodations, all in the Hill Country area, and see what catches your eye! It doesn't matter if you're planning a romantic weekend away, a trip with friends, or a family vacation, there is a little bit of everything here.
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Lindsay Road
Newhaven, Edinburgh, EH6 4DT
Property Details
Fully furnished double bedroom property in popular residential area. This property consists of lounge, double bedroom, kitchen, bathroom with shower and WC.
The property is ideally located close to the shops and cinema at Ocean Terminal, The Scottish Executive, Asda supermarket and the trendy Shore area. A variety of shops and restaurants are in the vicinity with various buses stopping nearby for travel throughout the city.
The flat benefits from gas central heating, free street parking and has a Virgin Media connection for telephone, cable television and broadband internet requirements.
To arrange a viewing, email or call us on our 24 hour telephone line.
Please leave your name and telephone number and state when you would wish to view the property. We will get back to you to arrange your viewing. Thank you.
EPC rating: C. Landlord Registration Number: 259617/230/21081.
Council Tax Band: B
- Washing Machine
- Shower
- Secure Entryphone
- Fridge Freezer
- Virgin Media Connection


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Not Rated | | Crime, Drama, Thriller
The lives of James, a directionless college dropout, and Webb, a career criminal with his back against the wall, violently collide.
Get to know the "Roswell, New Mexico" star as she takes our "Take 5" challenge and shares her favorite dance movie, dream role, and more.
Check out our guide to the Academy Awards, our coverage of the 2019 awards season, and more.


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Looking On The Bright Side Of Insurance
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Indoor Volleyball Join the SA Challenge team and help us take down UniSA and Flinders! See below information of the event itself.
2019 SA Challenge - Indoor Volleyball
By completing your SA Challenge registration, you agree to The SA Challenge Code of Conduct (please ensure you read this prior to payment).
Friday, 5 April
From 10-1pm (subject to change once draws are finalised)
Pridham Hall - UniSA
Team Size:
Each team shall adhere to the following minimum and maximum squad sizes:
Minimum 6
Maximum 10
*Two females minimum in the team
There is a limit of 1 team per University.
Email email@example.com for further information


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Spread a message of peace, comfort or joy at your religious, wedding or sympahty occasion with our wired and elegant two color foil stamped ribbon. Select items in stock, others will be shipping in January 2019.
Select a color:
(click swatch to change color in photo)
Select a width/size and put up/pack:


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Two wood tables manufactured by Laurits M. Larsen in Denmark. The smaller table stands 20" tall x 23" wide x 17" deep while the larger table stands 26" tall x 47" wide x 16" deep. Both are in very good condition.
Posted in: Furniture.
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