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Ribosomes, the site of protein synthesis, are a major target for natural and synthetic antibiotics. Detailed knowledge of antibiotic binding sites is central to understanding the mechanisms of drug action. Conversely, drugs are excellent tools for studying the ribosome function. To elucidate the structural basis of ribosome–antibiotic interactions, we determined the high-resolution X-ray structures of the 50S ribosomal subunit of the eubacterium Deinococcus radiodurans, complexed with the clinically relevant antibiotics chloramphenicol, clindamycin and the three macrolides erythromycin, clarithromycin and roxithromycin. We found that antibiotic binding sites are composed exclusively of segments of 23S ribosomal RNA at the peptidyl transferase cavity and do not involve any interaction of the drugs with ribosomal proteins. Here we report the details of antibiotic interactions with the components of their binding sites. Our results also show the importance of putative Mg+2 ions for the binding of some drugs. This structural analysis should facilitate rational drug design.
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We thank A. Hofmann for advice; A. Mankin and F. Triana for critical discussions; and T. Auerbach, H. Bartels, W. S. Bennett, H. Burmeister, C. Glotz, M. Glühmann, H. A. S. Hansen, M. Kessler, M. Laschever, S. Meier, J. Muessig, M. Peretz, M. Pioletti, B. Schmidt, A. Sitka, C. Stamer and A. Vieweger for contributing to different stages of these studies. These studies could not have been performed without the cooperation of the staff of the synchrotron radiation facilities at EMBL and Max Planck Gesellschaft at DESY, ID14/2&4 at EMBL/ESRF and ID19/APS/ANL. Support was provided by the Max-Planck Society, the US National Institute of Health, the German Ministry for Science and Technology and the Kimmelman Center for Macromolecular Assembly at the Weizmann Institute. A.Y. holds the Martin S. Kimmel Professorial Chair.
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...improvements to an existing App. I already have a design and working model but will need someone expereinced in C# and Swift, Android & Web based technologies who is competent to make some changes and inclusions to both Apps / IOS / Android and Web parts of our App. Main task will be to add more functionality and also to add within the App an option to email
Need a professional web coder who is really good at Word Press Coding & Optimising 1) Expert level in Wordpress - Familiar with PHP SQL coding & Javascript 2) Expert level in coding and C-panel, who can also give us suggestions on web server & security 3) How we measure your job: Through PageSpeed Insights & User experience What do you need to do
...the required libraries and environment per those instructions on github. I am not experienced in visual studio at all or with c++. I only do web development with php and html so this is new for me. I would like someone to either A, connect to my pc with team viewer and make these changes and compile for me while I record a video so I can learn how
...continuing on the project, the previous freelancer will be available for support for a while. ------- PROJECT DESCRIPTION: I need a professional iOS developer who can build me a top quality beauty/wellness classifieds app for the iphone and deliver to speed. To win my confidence in your skills and ability, you will demonstrate projects you've worked on with
We are seeking a Web Developer to join an exciting client of ours in Seattle. This person should be passionate about web development, and building exciting consumer-oriented applications. Responsibilities: • Gather requirements to design and plan software solutions • Implement software solutions by writing code in a matter consistent with company's
I have a small web application written in C# (ASP .NET). The following files are part of the application: [Zur Anzeige der URL Anmelden], [Zur Anzeige der URL Anmelden] [Zur Anzeige der URL Anmelden], [Zur Anzeige der URL Anmelden] Several .CS files Some of the code is built into a DLL ([Zur Anzeige der URL Anmelden]) I recently made changes to the code and I am getting an er...
...from the psd and an example provided to the dev area for testing including plugins, images, and templates for each section. Finally, the coder will publish the completed site on the new server. The current site will be provided to the coder selected along with specific instructions and new .psd to design from. Budget $165 Max Timeline to complete -
...users against Active Directory b. Fetch their roles from Active Directory c. Provide them application privileges [read/edit/approve/admin] fetched from Active Directory d. Read structure of a database table from the database dictionary e. Provide user the capability to search on list of tables e. Provide user the capability to search and read the records
...users against Active Directory b. Fetch their roles from Active Directory c. Provide them application privileges [read/edit/approve/admin] fetched from Active Directory d. Read structure of a database table from the database dictionary e. Provide user the capability to search on list of tables e. Provide user the capability to search and read the records


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Homeowners Insurance Trenton, UT
Are you searching for home insurance coverage in Trenton, UT? Enter your Zip Code to compare the best options available nearby. Comparing multiple quotes is the best way to save money on your homeowners coverage in Cache county.Have you been asked by your mortgage lender to get homeowners insurance? Did you just purchase your first home and understand the value of insuring it but don't know what type of coverage to buy? If so, here is some information to help you get the Trenton, Utah homeowners insurance you need.
Be aware that while some lenders will escrow you for insurance, they go about picking the plan for you. They also will charge you nearly double or triple what you could pay on your own.
What Home Insurance Is
When you start shopping for coverage, which you can do in person at an insurance agency or online at an insurance company website, you will notice that there are different types of coverage to choose from.
Understand that there are some exclusions to general or basic perils. These are terms you will face when you start examining what your potential policy covers.
What Homeowners Insurance Covers
Basic perils often come with exclusions or things that will not be covered by the policy. Be sure you understand what you are getting when you get your basic peril coverage. This type of coverage usually covers damage due to fires, lightning, wind storms, smoke, and vandalism.
A lot of people assume that coverage for things like floods, earthquakes or termite damage are automatically covered. This is not the case. Flood and earthquake insurance policies must be purchased separately or you must pay an additional fee to your insurer to have these specific types of coverage included.
There are also all-risk policies. These tend to cover everything, except any specific exclusions which the insurance company will detail for you in writing. Be aware that sometimes buying an all-risk policy means that things like floods or earthquakes are not included.Other things that you want to consider is the replacement cost for your home. You need to make sure you are buying enough coverage. For instance, you could choose a policy that pays you $500,000 in the event of the home's destruction. Make sure you base the replacement cost on more than just the current market value of the home.
Make sure to buy content coverage for any of your belongings inside the home. This may have limits, however, so make sure you know just what it will cover. Finally, ask your insurer about getting liability coverage so that in the event someone is injured on or around the home, you have protection.
Obtain quotes from insurance agents in person to get personalized help. Or, for more convenience, you can get Trenton homeowners insurance quotes free online. Protect your home with affordable insurance today.
More Utah Cities Nearby:
If you are feeling a little bit anxious about getting a home owner's insurance policies policy, you are not on your own. There are thousands and thousands of other property owners out there that truly feel just like you as this is quite crucial protection that is needed to defend your property and residence from loss. Make certain you are beginning with tips like these ahead of you begin purchasing.
Check out the status of your homeowner's insurance premiums at minimum after a yr, to see if you might qualify for a lower charge. Your present charge may be dependent on an aged crime statistic, for instance, or you might have set up a stability program that could decrease your charges. Examine these adjustments with your insurance coverage agent.
When you are dealing with property owners insurance coverage maintain in brain that some insurance policy companies will truly reduced your high quality if you get your home loan paid off. They will believe that because you own the home outright you are much more very likely to consider better care and satisfaction in your home.
Consider raising the deductible on your residence insurance coverage. A greater deductible on your insurance plan can substantially lower your once-a-year house insurance policy premiums. Regrettably, by raising the deductible, your house insurance policy business will no for a longer time spend for little promises, this sort of as damaged window repair, leaky pipe fix and small wind and flood injury repairs.
If you never stay in an location prone to floods, you probably have not even thought about obtaining flood insurance policies. Even so, it may be smart to have it. Dwelling in a low-risk spot for floods does not indicate that flooding will in no way take place to you. You can get a wonderful price reduction on your flood insurance policy if you might be in a medium or minimal-threat regions.
When you acquire a property, do not neglect to consist of flood insurance in your policy. Floods are not constantly coated by traditional homeowner's insurance policies, and current functions have made it distinct that flooding can happen in spots that usually are not anticipated. Even a small flood can result in a good deal of harm to your property, which is why you should be lined for this eventuality.
Ensure that your residence is sufficiently guarded with the suitable quantity of smoke detectors, and you could qualify for a price cut on your property owners insurance premiums. Setting up much more than the advisable amount of smoke detectors can also end result in a discount from some insurance coverage businesses. Check out your policy to see if qualify for a reduction in your rates.
At the very least once a 12 months examine the value of your home owners insurance coverage to that of other firms to see exactly where the cost savings are. You might quite nicely discover an additional organization supplying much better rates than your possess or a discount for signing up with them. If you believe you can get substantial cost savings with yet another insurance provider, get in touch with them up and explain to them you may well be fascinated and they might present you with even much better numbers to obtain you as a client.
Document all of your valuables and maintain the images or films of the items that you want coated below your residence insurance coverage, in a fireproof lockbox. This will protect your files and make submitting a claim for the missing or wrecked things with your house insurance policy business, easier and a lot quicker.
Getting a home owner's coverage is a requirement, especially if you will be funding your house acquire. The process can be perplexing even so, and navigating the insurance coverage industry, at times proves difficult. In this article, we have offered you with a number of guidelines that must aid you in making your assortment. Adhere to these guidelines to simplify the process of acquiring your following house owner's insurance coverage.


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The Confidential Secrets for What Is the Difference Between Cbd Oil and Hemp Oil Exposed
The Confidential Secrets for What Is the Difference Between Cbd Oil and Hemp Oil Exposed
CBD oil can be updated with unique flavors to raise the ability.indoor growing In turn, it might offer benefits for your acne. Coconut oil provides a lot of rewards.
The Tried and True Method for What Is the Difference Between Cbd Oil and Hemp Oil in Step by Step Detail
At the moment, twenty five states permit the purchase of bud, although perhaps not under the same ailments. The streamlined fluctuations such as feeling comfortable and focused during daily will force you to feel the progress, however, you've got to wait about for a little while to realise complete advantages of the compound. The differences are based on the role of the dental appliance.
The exact very same is true for CBD-rich berry answers. So, since you are able to see, cannabis will help inspire imagination and focus on nearly any endeavor. The worth of hemp have not but been abandoned over time plus now hemp continues to be employed in a large number of indicates.
What You Should Do to Find Out About What Is the Difference Between Cbd Oil and Hemp Oil Before You're Left Behind
Additionally, it might be infused into the human body and applied topically. For those who aren't sure which brand you ought to go together with, we advise you to have a peek at distinct CBD creams that will give you peace of mind in regards to pain and skin troubles. CBD oil could be used to treat and combat the problems that are associated with stress.
Notably, there appears to be quite a standard false impression that hemp and marijuana are the specific same matters. Although hemp oil really is a sort of cannabis oil, what's generally marketed as cannabis oil isn't the specific similar. Some may possibly think about cannabis vs hemp for a competition.
The cannabis plant has been owned from the genus Cannabis, therefore the title. The extraction is a protracted procedure and ought to be carried out attentively, with only highquality marijuana buds and also a wonderful solvent. The best way to ingest cannabis oil is contingent up on the type.
The Debate Over What Is the Difference Between Cbd Oil and Hemp Oil
To make CBD oil, you have to first begin with a tall CBD strain. Inflammation CBD oils are terrific anti-inflammatories. Of the cannabinoid compounds, it's generally CBD and THC (in addition to cannabinol or CBN) that exist in the greatest concentrations.
You really don't will need to get concerned about this as you consistently have the choice to finance and maintain your CBD organization afloat and going. A few CBD organizations are starting to offer CBD cartridges for that offer outcomes that are various. Therefore, if you should be looking in to buying CBD goods, you will want to be more certain they explicitly mention CBD around the bottle.
Because the amount of strains with higher CBD content has significantly increased, the amount of merchandise readily available on the current market which market CBD because the principal ingredient has additionally increased. Yes, and don't state you've not heard about any of it. CBD isn't an excellent or component of hemp seeds, and tagging that result is unsuccessful and prompted by the impulse to benefit in the legal gray field of CBD under national law enforcement.
The usage of CBD oil gets got the ability to lessen the possibilities of you ever having diabetes. In reality, the CBD petroleum has been deemed to be among the most useful alternatives as soon as it regards treating emotional disorders. CBD has positive consequences in a enormous selection of illnesses and has been demonstrated to improve standard wellbeing, hair and skin care.
So How About What Is the Difference Between Cbd Oil and Hemp Oil?
To start out with, equally plants seem emotionally diverse. Cannabis Vital Oil the weather of a CBD essential petroleum are really effective. While hemp oil may offer benefits being a piece of healthful diet, there is nothing when compared to the wellness advantages of CBD oil.
Hemp Oils and coconut oils are the oils. It's oleic acids and lactic acid which is greatly helpful to get healthful skin. Plants want Water to develop your own meals.
Maintaining a dose or concentration will not operate the danger of over dose. Using CBD oil is a exemplary treatment for sleeplessness. Popularly-used by women and men for treating several states and basic wellbeing, CBD is thought of as a non-psychoactive cannabinoid which is produced legal in 43 nations.
The What Is the Difference between Cbd Oil and Hemp Oil Cover Up
Scientifically, it is often analyzed for thwarting cancer development. The petroleum was which can help treat epilepsy and mental problems, aid in cancer remedy, also behave being an anti-inflammatory. You've learned just two of the most effective ways to treat a yeast infection in your house.


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+977-9801020350 ( Whats App / Viber )
Nepal is country which has the both historically and holistically most alluring destinations around the
world. The country is rich in spots of pilgrimage for both the devotees of Hinduism and Buddhism.
Surrounded by the incredible Himalayas and unbounded natural beauty, Nepal is acclaimed as an intact
place for religion, peace, and emancipation. The tour to these pristine pilgrimages is to be bucket listed.
Committed to Lord Shiva, Pashupatinath is one of the most divine religious destinations in Asia for an
ardent admirer of Shiva. Pashupatinath temple was remodeled by Malla kings and augmented in the 5th
century. The site is said to have come into existence from the ancient aeon when Shiva Lingam was
found here. Pashupatinath is the complex of magnificent sanctuaries, figures, Ashrams, and platform for
Hindu customs and incineration on the back of Bagmati stream. Pashupatinath is considered an arch of
12 jyotirlingas and the most essential of Shiva's residence as indicated by Tamil sacred texts.
Admired by both Hindus and Buddhist devotees, Muktinath temple is a symbol of religious mutuality.
Situated in a quaint location the pagoda-styled temple, Muktinath, is devoted to Lord Vishnu. Behind the
temple are the 108 water nozzles with the water flowing from Mansarovar. Hindus regard that Lord
Vishnu got emancipation from the scourge of Brinda here. Thusly, Lord Vishnu is revered as the aristocrat
of emancipation; Muktinath. This region is acclaimed for a bizarre consolidation of water, air, and fire
and earth element. This place is also known to the origin place of "Saligram". Mukti Kunda, Mukti Dhara,
Jwala Mai Temple, Mharme Lha Khang Gompa, Swaminarayan, and Saligram are the major attraction of
this area.
Halesi Mahadev
Situated in Khotang District of Nepal, Halesi Mahadev is regarded as another Pashupatinath in eastern
Nepal. Admitted to having been in existence since six thousand years, Halesi Mahadev is a natural cave
correlated with Lord Shiva to Hinduism and Guru Rinpoche in Buddhism. The three mysterious caves
existed here is believed to be three eyes of Lord Shiva. Particularly, during the celebration of Shivaratri,
Ram Navami, and Ganesh Chaturthi many devotees from Hindu and Buddhist community come to visit
this place. The expedition to Halesi Mahadev is also the exploration of nature and experience of local
tradition as well as lifestyle.
Hiking Adventure has been organizing the pilgrimage tours and has been able to establish itself as one of
the most reliable operators for the safest tour to such pilgrimage sites. The main motive of organizing
this pilgrimage tour is to ease devotee in visiting the sacred places.
The itinerary listed is a guideline and standard pattern which we provide you. This trekking can be modified according to your time and requirements. We will be pleased if you provide every minor details about your trip.
Nepal doubled its tiger population in the span of eight years. It further commits to conserve..
Figure 1: The word "Nepal" originally referred to the valley of Kathmandu. As it was..


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Carved in Stone
Archeologist and folklore expert Nate Murdock has discovered ancient stone carvings that will either revolutionize thinking in his field or get him laughed out of it entirely, and he's hired world-renowned photographer Alex Martin to document his find and bolster his claim. When the alluring Alexandra Martin, not Alex, shows up for the job, Nate's not sure whether to send her packing or take her into his arms.
Alexandra Martin, the daughter of the famed photographer and just as talented with a camera, is a dark-haired and dark-eyed beauty. Years ago her father built his reputation on photographs he'd stolen from her, and she's out to prove once and for all that she's the real deal. When the opportunity to work with the celebrated and ruggedly handsome Nate Murdock falls into her lap, she jumps at the chance—whether he likes it or not.
As tempers flare and accusations fly, the two dig in for a battle of wills and an uneasy truce at their remote mountainside camp. But when drug smugglers trap them in a cave and leave them to die, Nate and Alexandra realize they must trust each other—and the fiery passion growing between them—and surrender to a mysterious force as it guides them through a perilous escape and the acceptance of a powerful love as primal and compelling as the mountain itself.
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Latest News
- First Released
- September 10, 2010
- Platforms
- wii, ps3, xbox-360
- Genre
- Sports
- Rating
- Rated "E10+" for Mild Violence
- Summary
- This is the ultimate tournament event for winter sports. Play alone or online with a friend and enjoy the coolest sport the winter season has to offer. Play in eight exciting sports and develop your career in single-player or compete online in gripping multiplayer matches.


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Enter your e-mail address and password below.
Ten-month lows in key interest rates couldn't stop mortgage
applications declining for the third straight week, the Mortgage Banking
Association (MBA) reported this morning.
For the week ending Feb. 1, the MBA's Market Composite Index
— a measure of mortgage loan application volume — decreased by 2.5 percent on a
seasonally adjusted basis from one week earlier. Compared to last year, loan
volume was down nearly 10 percent. The Index increased by 12 percent without
seasonal adjustments.
Purchase volume showed the biggest hit, with MBA's Purchase
Index down by 5 percent (seasonally adjusted) from the previous week.
Unadjusted, the Purchase Index rose by 13 percent from the previous week, but
was 2 percent lower than the same week in 2018.
The unadjusted Refinance Index, on the other hand, increased
by 5 percent from one week earlier. The refinance share of mortgages fell
marginally to 41.6 percent, down from 42 percent the previous week.
MBA noted the drop in demand despite the average interest
rate for 30-year fixed-rate mortgages with conforming balances decreasing to
4.69 percent. That rate, the lowest since last April, was down from 4.76
percent a week earlier. Points were also down, decreasing to 0.45 from 0.47
(including origination fees) for 80 percent LTV loans.
Other interest rates saw similar decreases. The average rate
for 30-year fixed-rate jumbo loans decreased to 4.5 percent from 4.6 percent,
with points increasing to 0.28 from 0.24 (including origination fees) for 80
percent LTV (loan to value) loans. The average rate for 30-year fixed-rate Federal
Housing Administration (FHA) mortgages fell to 4.7 percent from 4.77 percent,
with points falling to 0.57 from 0.58 (including origination fees) for 80
percent (LTV) loans. For 15-year fixed rate mortgages, the average interest
rate decreased to 4.11 percent from 4.16 percent, with points up to 0.47 from
0.46 (including origination fees) for 80 percent LTV loans.
"Despite more favorable borrowing costs, and after a
three-week surge in activity, purchase applications have slowed over the past
two weeks, and are now almost 2 percent lower than a year ago," said Joel
Kan, MBA associate vice president of Industry Surveys and Forecasting.
Kan added, however, that the robust job market and
moderation in price gains should signal future purchase growth.
Questions? Contact Arnie Aurellano at (425) 984-6019 or firstname.lastname@example.com.
PreviousHome-price gains slowest since 2012
NextLuxury home sales down for first time in two years
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245 Results
Luxury Style Villa with Panoramic Views in Benahavis, MarbellaBenahavis 5 Bedrooms, 6 Bathrooms, 970 m² This luxury villa has been inspired on its privileged location and exceptional sea views together with an Andalusian style. The villa has 3 levels accessible through its imperial stairs as well as a modern elevator. The traditional roofs together with… Read More €2,950,000
Exceptional Private Villa on 6 Acre Plot, La Quinta, MarbellaBenahavis 8 Bedrooms, 8 Bathrooms, 1620 m² An exceptional and stunning property set on a huge plot of over 6 acres and located in a very private community with 24 hour security. The villa is designed with luxurious Mediterranean architecture and has stunning views over the sea,… Read More Price on Application
Luxury Modern Villa with Stunning Sea Views, Elviria, MarbellaMarbella East 8 Bedrooms, 8 Bathrooms, 955 m² A luxurious and spacious villa in a beautiful and peaceful location in East Marbella. Boasting stunning sea views, this is a wonderfully renovated villa in a superb location at just 10-15 minutes' distance from Marbella and Puerto Banus respectively. It… Read More €3,500,000
Unique Contemporary Villa in Bel-Air, MarbellaEstepona 4 Bedrooms, 4 Bathrooms, 743 m² The design of this villa originates from a classical symmetry reinterpretation. Brings to life a double height porch that recalls of monumental buildings during classical Rome. This rotund element framed by natural black stone outlining a minimalist effect. The entrance… Read More €1,400,000
Luxury Beachfront Villa in The New Golden Mile, MarbellaEstepona 5 Bedrooms, 5 Bathrooms, 1053 m² A true jewel on the second line beach and surrounded by everything you need. Located on the New Golden Mile, Parador Barronal became over the years the reference area for all those who seek tranquility and luxury right on the… Read More €4,500,000
Spacious Detached Villa with Panoramic Sea ViewsNueva Andalucia 4 Bedrooms, 4 Bathrooms, 383 m² The project of five villas is located in the most luxurious and demanded area of Marbella, The Golden Mile. Enjoy stunning panoramic sea views. Spacious detached villas enjoy stunning sea views, stretching from east to west along the Mediterranean coastline,… Read More €1,900,000
Luxury South Facing Apartment, Golden Mile, MarbellaMarbella City & Golden Mile 3 Bedrooms, 3 Bathrooms, 200 m² A very spacious luxury ground floor apartment. South facing and private. Close to Marbella centre, Puerto Banus and the beach. The apartment comprises : living and dining area with fireplace and high ceilings, open plan fully fitted modern kitchen. Master… Read More €840,000
Luxury Penthouse with Sea Views, Nueva Andalucia, MarbellaNueva Andalucia 2 Bedrooms, 2 Bathrooms, 260 m² This superb penthouse is located in a sought after urbanisation approx. 6 km West of the centre of Marbella. The harbour of Puerto Banús and the lovely beach are within a few minutes' driving distance. Numerous golf courses, shopping facilities… Read More €1,695,000
Modern Luxury Villa with Spectacular Views in Estepona, MarbellaEstepona 4 Bedrooms, 4 Bathrooms, 223 m² A modern luxury villa with spectacular panoramic sea views from any corner of the house in Puerto de la Duquesa. Designed and set on 2 levels, with floor to ceiling windows that allow light to enter the interior and is… Read More €985,000
Frontline Golf Villa with Beautiful Views in Guadalmina Alta, MarbellaSan Pedro de Alcantara 4 Bedrooms, 4 Bathrooms, 410 m² Luxury villa for sale in Guadalmina Alta with beautiful views to the Guadalmina Golf Course. It is a perfect choice for golf enthusiasts. Near the beach and a top quality commercial center just around the corner, the frontline golf villa… Read More €875,000
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Interest in the ketogenic diet is at an all-time high, and for good reason. It's a great way to lose body fat, gain steady energy throughout the day, increase fat-burning capacity at rest and during exercise, reduce inflammation, and improve cognitive function. Keto also has a number of promising medical applications, including seizure control, enhanced efficacy of chemotherapy, and abatement of age-related cognitive impairment.
I've tried this, got a few bags of one ketone salts bound to mostly potassium and another one bound to calcium. As for working out, I find that consuming 15-20 grams of glucose ( dextrose ) 30 minutes before either a HIIT or a heavy lifting session gives me a much, much bigger boost than ketones. so they just sit in my cupboard. I also got spooked about the amount of potassium i'd consume in one go ( don't particularly fancy a cardiac arrest ). I find it a bit useful when I have a big meeting or something else that requires super concentration and I'm fasting, other than that – it's pretty useless. I'd probably use more of it if I could find a formula that's mostly sodium/magnesium based rather than potassium and/or calcium.
The liver is always producing ketones to some small degree and they are always present in the bloodstream. Under normal dietary conditions, ketone concentrations are simply too low to be of any significant benefit. A ketogenic diet and exogenous ketone supplements will increase the amount of ketone in your body. The idea that ketones are "toxic" is ridiculous. Ketones are a normal physiological substance that play many important roles in the human body.
The reason for testing after one hour was based on Prüvit's "59-minute test", which recommends testing ketones 45-60 minutes after taking the supplement (by the way, saying "59 minutes" instead of 60 minutes or 1 hour just sounds like another marketing gimmick to me). Kegenix Prime also promises "ketosis in 60 minutes" on its packaging. We carried out the testing at more or less the same time each day.
The ketogenic journey should be more of a lifestyle than one that acts like a fad. So taking more than a day for your body to enter ketosis should not be the greatest of concern. It's more important to stay discipline and to consistently keep your body in a fat-burning state. Although, if you are someone who has fallen out of ketosis after a cheat day, or rather somebody who is just starting out and finding it longer than expected to enter ketosis, then this article can definitely help in that respect. It's nothing new, and it's definitely no secret but strict dieting, fasting, exercise, controlling stress levels, sleep, and certain supplements can help you boost ketogenesis!
If you have already mastered the Very Low Carbohydrate (VLC) or ketogenic way of eating, and/or are eating at a caloric deficit, exercising or fasting you are naturally creating the optimal conditions for your body to produce ketones and put your body into nutritional ketosis. By strict adherence to a well-formulated ketogenic diet (complete with higher levels of mineral salts) you should be able to produce all the ketones you need naturally (endogenously). If you are new or inexperienced in ketogenic eating however; or if you or a family member struggles to adhere to a ketogenic diet, then supplementation with exogenous ketones may be very beneficial. Not only will ketone supplements help to mitigate hunger and carb cravings, but they will also help you stave off carb flu symptoms (see below), giving you the best possible chance of long-term success.
Despite the recent growth of the ketone salt market, there is very little published work analyzing the effects of these products on any biomarkers or performance measurements in humans. Several studies have been carried out in rats,6,7 with blood BHB levels being relatively low (<0.5 mM) post-consumption of salt drinks. In humans, ketone salts provided peak D-BHB levels of 1 mM, whereas the same amount of BHB in a ketone ester (BD-BHB) raised blood BHB to 2.8 mM.5
Ketones are produced by the body as a indicator of the body starting to use fat for fuel. Your body then uses those ketones as brain fuel (mostly) , but if you were to have a carb meal it would kick your body out of ketosis (fat burning state) because the carbs are a more easily usable source of energy. So why would you want to add a outside source of energy such as ketones not naturally produced by the body its self? It would kick you out of the fat burning state just like the carbohydrate meal because your body rather spare it's own energy source as much as possible and also since the outside source ketones are not naturally produce by the body your body does not go into fat burning state because it doesn't have to go through the natural process to produce its own ketones meaning the body is in its fat burning state since ketones are a by product of fat being used as fuel. Your body has to go through the natural process by itself. Outside ketones are treated as a alternative fuel source so your body has no reason to use fat as its fuel source. Just like carbs. Don't fall for the scam do your homework it's science backed up by facts. https://www.t-nation.com/diet-fat-loss/avoid-this-ketogenic-rip-off
If you are not on a vigorous exercise plan, I wouldn't go more than about a scoop a day (if you are a 30min/day, low carb person like me) because some of the research available says that if you get into ketosis using diet only and supplement with extra ketones, you may experience a slower rate of weight loss since you are getting your ketones from a supplement rather than the body transforming fat to ketones. As I progress, I will probably move up to 2 scoops per day.
Ketone Esters: These are not normally found in the body, but exogenous ketone esters convert into BHB once it is in the body. They are also synthetically (lab) made compounds that link an alcohol to a ketone body, which can then be metabolized by the liver into a ketone. They are like ketone salts on steroids as they have 5-10 time more BHB per serving/maximum daily intake than ketone salts. To date, pure ketone esters have been very expensive to produce and have only been available to researchers, elite athletes (Tour de France cyclists), and the US Department of Defense (people have spent more than $20,000 to have an independent lab produce a single serving!).
Good question. There have been many tests and studies that have been conducted to see if ketogenic supplements genuinely do work and many of these studies have shown that ketosis theories are correct. Adding ketones to your body and using fats as a resource of energy has some fantastic effects and if done right can help your body fight all sorts of ailments such as cancer, heart disease, diabetes and many other illnesses that can only be cured by chemical therapy. Keto therapy or nutritional ketosis is paving the way for more natural solutions, and it's a good thing that scientists have created these exogenous ketone supplements that help us induce more ketones in our body.
There is one viable explanation for consuming ketones. If you're in a calorie or carb-restricted state, then maybe during a workout it would make sense. But even then, that really only applies to endurance activities, since it has more to do with enhancing aerobic performance (where oxygen is required), than it does with enhancing high-intensity efforts (where it's not).
As seen in this exercise, glucose tends to fall quite precipitously following exogenous ketone ingestions. Without exception, every time I ingested these compounds (which I've probably done a total of 25 to 30 times), my glucose would fall, sometimes as low as 3 mM (just below 60 mg/dL). Despite this, I never felt symptomatic from hypoglycemia. Richard Veech (NIH) one of the pioneers of exogenous ketones, has suggested this phenomenon is the result of the ketones activating pyruvate dehydogenase (PDH), which enhances insulin-mediated glucose uptake. (At some point I will also write a post on Alzheimer's disease, which almost always involves sluggish PDH activity —in animal models acute bolus of insulin transiently improves symptoms and administration of exogenous ketones does the same, even without glucose.)
Administration of ketone supplementation significantly reduced blood glucose over the course of the study (Fig. 3a, b). MCT (5 g/kg) decreased blood glucose compared to control within 30 min which was sustained for 8 h at baseline and at week 1. MCT (10 g/kg) likewise decreased blood glucose within 30 min and lasted through the 12 h time point during weeks 2, 3, and 4. BMS + MCT (5 g/kg) lowered blood glucose compared to control from hours 1–8 only at week 1. BMS + MCT (10 g/kg) lowered blood glucose compared to control within 30 min and remained low through the 12 h time point at weeks 2, 3, and 4. Rats supplemented with BMS had lower blood glucose compared to control at 12 h in week 4 (10) (Fig. 3a). Administration of BD did not significantly change blood glucose levels at any time point during the 4-week study. KE (5 g/kg) significantly lowered blood glucose levels at 30 min for week 1, 2, 3, and 4 and was sustained through 1 h at weeks 2–4 and sustained to 4 h at week 3. (Fig. 3b).
Over five visits, participants (n = 16) consumed either 4.4 mmol.kg−1 of βHB (2.2 mmol.kg−1 or 395 mg/kg of KE; 1 mole of KE delivered 2 moles of d-βHB equivalents): twice whilst fasted, and twice following a standardized meal, or an isocaloric dextrose drink without a meal. To improve palatability, drinks were diluted to 500 ml with a commercially available, citrus flavored drink containing 65 kCal (5 g of carbohydrate) (Glaceau, UK). The dextrose drink was taste-matched using a bitterness additive (Symrise, Holzminden, Germany). The standard meal consisted of porridge oats (54 g), semi-skimmed milk (360 ml) and banana (120 g), giving 600 kCal per person, with a macronutrient ratio of Carbohydrate: Protein: Fat of 2:1:1.
Keto dieters love exogenous ketones because they help fight the keto flu and get you quickly into ketosis. One study found that taking drinks with exogenous ketones lowers blood levels of glucose, free fatty acid, and triglycerides [8]. The study concluded that exogenous ketones are a practical and effective way to achieve ketosis. Taking exogenous ketones longer will also speed up the process of keto-adaptation.
As KE drinks achieved a significantly higher d-βHB concentrations than KS, we investigated factors that may be important in the use of ketone drinks to achieve nutritional ketosis. Initially we determined the repeatability of blood ketosis following KE drinks and found little variation in kinetic parameters between individuals. Variability between participants was less than within the population, and accurate individual prediction of the d-βHB Cmax following a body-weight adjusted KE drink was achieved. Variability within individuals was likely due to normal daily changes in GI function, including gastric emptying, portal blood flow or intestinal transit time, which may alter KE hydrolysis and absorption.
I heard a rep from Perfect Keto on a podcast and your Exogenous Ketones. I ordered and received it the other day. I see from this article that I should not do a full scoop at once, but break it up in a day. Good to know. I had about a half scoop before I worked out this morning and could tell I had more energy. Loved that. Just curious….any ideas how long it will take me to get back into ketosis and fat burning?? (I know it depends on what I eat, but a general idea that I promise not to hold you too! (I'm actually missing having 'keto breath!)
Response inhibition is the ability to suppress inappropriate responses that interfere with goal-directed actions. Two cards are shown, one above the other, each containing the name of a color in a certain color. The goal is to rapidly indicate if the meaning of the color on top (i.e. "yellow") matches the color of the color on the bottom (i.e., card says "red" but is colored yellow).
Halitosis (bad breath) – If you're on a ketogenic diet you are probably aware that as the body starts to metabolize fat, ketones can cause poor breath. There is very little one can do about this, it's just the nature of the beast. Unfortunately, this can also arise when using exogenous ketones, but it's not as lasting as when on a ketogenic diet. Chewing gum or mints is about the best option if it becomes a noticeable issue. This maybe caused by over consumption of the ketone supplement, tailoring the quantity consumed may prevent excess BHB being converted to acetone, which is likely excreted by the lungs.
Full disclosure: after carrying out the background research, I was already, as you might imagine, feeling a little less neutral about these products. You may have noticed a hint of that in part 1 of the 2-part video series we made about the project (watch part 2 at the top of this page!). However, and although this was by no means a controlled scientific study under laboratory conditions, we designed the experiment in a very objective way. The aim was to give the supplements the best possible chance of showing the benefits they are claimed to have.
I'm already following a ketogenic diet and have been fat adapted for about 3 months. Since I'm already in ketosis would this product help me or hinder my fat loss? My thought is that if I'm already in a fat burning state and then I take exogenous ketones does my body stop burning my fat to burn the ingested ketones like taking a break or does the product enhance the fat burning that is already taking place?
Exogenous ketones have a wide range of benefits that can enhance your fat-burning lifestyle. I personally use them daily as a strategy to heighten my mental performance and give my workouts an extra boost. For these purposes, I have also found it logical to combine exogenous ketones with other known health and performance boosting agents such as branched-chain amino acids and medicinal mushrooms.
Geek note: Technically speaking, beta hydroxybutyrate is NOT a legitimate ketone body. Ketone bodies, or ketones are technically molecules with carbonyl carbons which are bonded to two additional carbon atoms. One carbon has four available bonds. When that carbon is double bonded to oxygen and also has two single bonds to carbon, we have a ketone body. If you have a carbon atom that is double bonded to an oxygen (carbonyl group), which is also bound to an -OH group instead of two different carbon atoms, that would be a carboxylic acid, but that really doesn't matter in this case. For all intents and purposes of the ketogenic diet, betahydroxybutyrate should be considered one of the three ketone bodies and a "ketone" nonetheless. Your body uses BHB pimarily for energy in the state of ketosis, so it's a ketone, okay?
Before that though, I do want to touch on MCT oil and it's impact on ketone levels. MCT – or Medium Chain Triglyceride – are fatty acids that bypass the liver – and become quick energy for the brain and muscles. As they are a fat based energy source (and not a carbohydrate) they are quickly converted into ketones. This means MCT oil is a great way to boost ketone levels in the body.
Another important difference between endogenous and exogenous BOHB is that most synthetic BOHB used in dietary supplements is a mixture of the two 'D' and 'L' isomers, whereas endogenously produced BOHB consists of just the D-isomer. Metabolically, the two isomers are very different, and current published information indicates that most of the energy and signaling benefits of BOHB derive from the D-form. This is potentially problematic because the L-isomers are not metabolized via the same chemical pathways as the D-forms (Lincoln 1987, Stubbs 2017), and it remains unclear whether humans can convert the L-form to the D-form.
Great question. We can't see any reason this can't be a part of a successful weight loss program on the ketogenic diet. In the morning with coffee is a very popular way to raise ketone levels in the morning. See if you are on pace with your goals and perhaps try a week with a different breakfast to see what feels best. Also – new article might be helpful here too: https://perfectketo.com/exogenous-ketones-for-weight-loss/ Good luck! 🙂
Various reasons can motivate you to get into ketosis as part of the Ketogenic Diet. These may range from medical purposes so that you stay healthy, to keeping various ailments away. If you are an athlete, you may get into ketosis to keep your body fit for the upcoming competitions. Some people get into ketosis just to shed some extra fat and keep their bodies in perfect shape. Regardless of the reasons, here are practical tips on how to get into ketosis in 24 hours.
That's exactly what ketones do: inhibit lipolysis, the breakdown of body fat into triglycerides and free fatty acids for burning. In normal conditions where ketones are produced endogenously, this is expected and beneficial. If homemade ketones increased lipolysis, you'd end up with ketoacidosis. You'd make ketones which released more body fat which got turned into more ketones which released more body fat which became more ketones. And on and on. It simply wouldn't stop.
If you read about ketosis in magazine or heard about it in a podcast and wanted to jump on the bandwagon, then I think you should avoid it. Remember, it is a strict diet, and the potential health downsides may not be worth the upsides, unless you are working with a medical professional and or you are tracking your labs to see what's going on with your health (thyroid).
Intermittent fasting is using the same reasoning – instead of using the fats we are eating to gain energy, we are using our stored fat. That being said, you might think it's great – you can just fast and lose more weight. You have to take into account that later on, you will need to eat extra fat in order to hit your daily macros (the most important thing). If you're overeating on fats here, you will store the excess.
I also concluded that post by discussing the possibility of testing this (theoretical) idea in a real person, with the help of exogenous (i.e., synthetic) ketones. I have seen this effect in (unpublished) data in world class athletes not on a ketogenic diet who have supplemented with exogenous ketones (more on that, below). Case after case showed a small, but significant increase in sub-threshold performance (as an example, efforts longer than about 4 minutes all-out).
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Medical Disclaimer: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.
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It's an excellent opportunity to offer technical training courses that teach people how to learn a much-needed skill, or accomplish an important task. It could also prove to be an important testing ground for your educational courses. If you are able to market your course on the site, against direct competition, you may be able to direct marketing to the general public, using a website, videos, or even an affiliate marketing program.
Sell plasma. After passing an initial screening, you can usually sell your plasma for anywhere from $25 to $50 per donation. To qualify, you'll have to stand in a long line or show up early, be willing to fill out a very personal questionnaire, and endure a painful needle prick or two. Still, selling plasma is a great way to raise money fast – if you can stand the hassle.
Remember, the skills you have are an asset, they are your "unfair advantage." They are essential to your unique personal brand, and you can start making money online using those skills if you have the right strategy, tactics, and mindset in place. Another way to describe this is your "unfair advantage," a term I was first introduced to by Lain Ehmann in SPI Podcast Session #37.
Not quite ready to start your own blog, but still like the idea of getting paid to write? You may want to consider trying your hand at freelance writing. Many bloggers and website owners are willing to shell out some serious cash for high quality writers. In fact, Holly Johnson from ClubThrifty.com makes over $200,000 per year from freelance work! And she has a course that teaches others how to do the same.
Become an Amazon Associate and then use Keyword planner to find an in-demand niche: With more than a million different products to choose from and up to 10% commission the sales you drive, Amazon's affiliate program is a great place to get started. Browse their available products and see what connects with you. Or take it a step further and use Google's Keyword Planner to quickly check how many people are searching for a specific term. With affiliate marketing, the more relevant traffic you can pull in, the more you'll make off your site.
In the course bio for a lifestyle course on Gratitude, Passion and Success, she says, "The journey is going to be fun (that is the ONLY way that I know to do things) and filled with real life solutions and tools. And even better, we will be accountable to each other! We are going to look in the rear view mirror and be amazed at how far we have come!"
Life can be tough for real estate professionals these days. Even with interest rates at historically low levels, the uncertain economy makes homeowners hesitant to relocate or trade up. There just aren't that many clients out there, and the few who exist generate fierce competition. In fact, it seems the single ""hot area"" is foreclosures. But that's not necessarily bad news.
If you have experience with marketing, SEO, or a knack for getting people excited about the products and services you use on a regular basis, think about refining your skills and putting them to work making money online as a small business marketing consultant in your region—especially if you can become a local SEO expert and can help local clients rank higher in their search results.
Use the law of supply and demand to your advantage. Most of us are familiar with the law of supply and demand--the more there is of something, the cheaper it is; conversely, the rarer the product or service, the more expensive it is. However, other than when we get to a toy store before sunrise to get on line for the latest fad toy that kids can't get enough of, we don't really apply the law of supply and demand to our own lives--particularly our careers. For example, if you're aspiring to do something that many, many other people want to do (so much so that they do it for free, as a hobby) then it will be far more challenging for you to make money doing it. On the other hand, if you do something that most people don't want to do, or if you get very good at doing something most people don't do all that well, then you can make a whole lot more money. In other words, choose a career in pharmacy over photography.
If you're a fitness buff and have the right combination of charisma and business sense, working as a part-time online personal trainer can be both physically and financially rewarding. Once you build up a reputation and client base for yourself, it could easily turn into a full-time endeavor for you. Check out this interview with several fitness blog owners who are making a living online, from MonetizePros. As well, I'd recommend checking out this resource if you want to take this business idea seriously and get started with a business plan for your personal fitness trainer business today.
Set your price. Usually, websites sell for 3-5 times the yearly revenue. So if you had a blog for six months that made $30,000 in those six months, your yearly revenue would be about $60,000. You could then sell your site for $180,000 or more depending on your buyer. Bigger companies are most likely to spend larger amounts of money on a website than small companies are.
Learn as much as you can about the various types of Internet businesses. Some businesses are more profitable than others. Some have start-up costs and may require ongoing advertising dollars in order for you to sustain some level of profitability. Learning about the various types of Internet businesses can help you decide which one will be the best opportunity for you.
Redefine wealth. In studies of millionaires, people are surprised to learn that most millionaires aren't doctors, lawyers, and corporate leaders with big houses and fancy cars; they're people who religiously live below their means and invest the surplus into assets, rather than liabilities.[3] As you're taking the above steps to make more money, keep in mind that increased income does not necessarily equal increased wealth. Most people who flaunt their wealth actually have a low net worth because their debt to asset ratio is high--in other words, they owe a whole lot more money than they actually have. All of the previous steps have outlined aggressive strategies for making money, but you'll never get anywhere if you have a hole in your pocket.
Become a proofreader. All kinds of businesses hire professional proofreaders to look over their copy and content for errors before they publish. This side hustle is one that could work for nearly anyone since you can work from home provided you have a computer and an internet connection. You can find online proofreading jobs through websites like Indeed.com and FlexJobs.com
What a huge, great list of ideas – bookmarked this as I know I'll be coming back to go over it again and again. Here's another item that could have made the list. I found a financial directory that's useful for info on making money online. It's http://money.madbeetech.com. What I like about it is that each directory listing includes ebooks and videos that can be instantly downloaded. All sorts of stuff for people who have their own website, and people who don't (but still want to make money online).
Getting businesses to advertise on your podcast, either at the beginning or end or both is a great way to create a revenue through podcasts. Most businesses won't be keen to advertise on your podcast until you can prove a large number of listeners. Therefore, it is unlikely you will be able to start out from the get-go with sponsors. But once you accumulate regular listeners or a high number of downloads from iTunes, you can start to sell advertising space on your podcasts.
The larger the company, the more requirements and prerequisites they likely have in place. That's not necessarily a bad thing. Even though you may need a newer computer, they may be offer health insurance and a full-time schedule. There's always a trade-off. Know that more scheduling freedom and flexibility and less management oversight may mean lesser pay or no benefits.
This is a good book to read if you want information about how to buy small apartments with other peoples money. It doesn't seem as hard as flipping houses in comparison and apparently you make a lot more money. Interesting read. I would recommend it to those who have ever thought about buying, investing or flipping apartments instead of houses. Not as complicated as you may think. I learned something.
With any business, there are ways you can get started putting a lot of money down upfront. There are also ways to start an online business that don't cost much. With the affiliate marketing business model, the startup costs are low, but you will be relying on organic traffic. Some affiliate marketers rely too heavily on paid traffic, which will quickly eat into your profits. Put work into your search engine optimization (SEO). It will pay off in the long run.
Do you constantly come up with witty one-liners? Do you dream of the days of Mad Men-style advertising? If you've got some branding chops or just come up with imaginative copy, there are lots of opportunities to make money online through company naming and slogan contests. If you think you have a knack for names check out namingforce.com and squadhelp.com. If you dream of coming up with witty copy, try coming up with company slogans on Slogan Slingers and Get a Slogan.
Try pet sitting.[22] Find friends who are going out of town and offer to take care of their pets while they're gone. Professional boarding places tend to be very expensive (not to mention impersonal and intimidating for a pet), so your cozy little house or apartment may seem like a very nice alternative. Around the holidays, pet-boarders fill up quickly, meaning you can probably charge more.
Sign up for a reputable affiliate network: Aside from Amazon, there are dozens of large reputable affiliate networks, such as Share-A-Sale, Clickbank, and Skimlinks, that specialize in connecting you with merchants who are looking for affiliates to sell their products. They charge relatively low commission fees for the privilege of connecting you with merchants, and the merchants on these sites tend to offer much higher commission percentages or set dollar amount payouts.
Some subjects are much better paid than others, so although you may love the idea of writing about travel (badly paid) a better bet would be a niche like finance (much higher rates of pay). Check out the Pro Blogger job board for high paid freelance writing jobs – other places to look might be Textbroker or you can look at the "gigs" section on Craigslist.
Be proactive. Remember Murphy's Law: "Whatever can go wrong will go wrong." Make plans, complete with as many calculations as possible, then anticipate everything that can go wrong. Then make contingency or backup plans for each scenario. Don't leave anything to luck. If you're writing a business plan, for example, do your best to estimate when you'll break even, then multiply that time frame by three to get a more realistic date; and after you've identified all the costs, add 20% to that for costs that will come up that you didn't anticipate. Your best defense against Murphy's law is to assume the worst, and brace yourself. An appropriate amount of insurance may be something worth considering. Don't forget the advice of Louis Pasteur, a French chemist who made several incredible breakthroughs in the causes and prevention of disease: "Luck favors the prepared mind."
If you're running on fumes, financially speaking, but you have some money coming your way soon, consider pawning something of value to borrow fast cash. Of course, to get those items back you'll need to pay back the loan with interest. If you don't pay it back in time, that you'll lose the item. If it's really something that has a lot of intrinsic value to you, don't do it. But if it's something that doesn't, you can certainly consider it depending on your situation.
The extent to which companies have dug into and captured children's social work is not only deep but also wide. It includes companies being funded by central government to shape the future education and accreditation of children's social workers and managing the short-term money the government is making available for "innovation" in children's social services, trumpeted as additional funding but minuscule when set alongside the real reduction in government grant.
White labeling products involve purchasing pre-made products from a supplier and then adding your own labeling and branding. Products could range from candles to gym equipment or even tea, but all will come without labels, allowing you to create your own new range of merchandise. Most suppliers will advertise the fact they offer white labeled goods on their websites, so pick your niche and then find the right supplier and product for you. Once labeled, products can be sold via sites like eBay and Amazon, or from your own eCommerce store (discussed in a moment).
You could also opt to use existing websites for making money. These include both active income and passive income methods. For example, you could sell some used items or invest in creating some digital designs that then can be sold on merchandise. Again, devote a sizable portion of your time to passive income so that you can slowly build up earnings that will arrive on autopilot without any extra added effort.
Websites like Care.com connect parents with babysitters. The company does all the background checking and other due diligence to put parents' minds at ease. Of course, you can appeal directly to people in your personal network, but if you're looking to generate recurring revenue sign up with a site marketing to parents looking for child care services.
One of the most beautiful and exciting qualities about blogging is that you can create a blog that deals with any subject area that you are either knowledgeable or passionate about (and preferably both!). You can write about personal finance, careers, real estate, getting into business, technology, cooking, travel, personal health, or just about any topic you choose.


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3 men jailed after £60,000 found in sock drawer
As part of an ongoing investigation into drug supply officers from GMP's Serious and Organised Crime group identified three key players who were responsible for heroin being passed
Two jailed after a family were attacked in their home
Two people have been jailed after a family were attacked in their own home in Cheetham Hill.
Man jailed after assault on heroic police officer
PC Joanne Aitken was struck while apprehending Anthony Woodhead Robertson in Moston on 15 May 2018, causing a deep laceration wound
Man charged after assault during protest
James Goddard (17/07/1989) of Kelvindale Drive, Altrincham has been charged with assault and a public order offence
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