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Infections caused by Gram-positive pathogens, including Clostridium difficile, are a leading cause of mortality. Three species?methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae and vancomycin-resistant enterococcus (VRE)?are responsible annually for at least 84% of deaths due to antibiotic- resistant infections. C. difficile is the most common and costly healthcare-associated infection with an estimated 29,000 deaths annually. Only one new antibiotic, fidaxomicin, has been approved in the last 30 years for treatment of C. difficile infection and recurrence rates are still high for infections involving hypervirulent strains. There is a desperate need for new drugs with improved efficacy. Unlike the costly and time-consuming process of de novo drug discovery, drug repurposing is a novel method to reduce the time, cost and risk associated with drug innovation. Studies proposed in this application focus on repurposing one non-antimicrobial approved drug, auranofin, and one clinical molecule, ebselen. These two agents possess potent antibacterial activity, in a low nano molar concentration achievable at a clinical range, against multidrug-resistant pathogens, including MRSA, VRE, and C. difficile. We have demonstrated (in vitro and in vivo) that both drugs are superior to drugs of choice and are capable of 1) killing intracellular and persistent MRSA, 2) disrupting adherent staphylococcal biofilms, 3) suppressing key virulence factors including toxin production, 4) reducing excessive host-inflammatory responses associated with these toxins, 5) significantly reducing both the bacterial load and levels of the pro- inflammatory cytokines in MRSA skin lesions, and 6) enhancing wound healing. Both drugs have additional advantageous qualities against C. difficile including; a) potent activity achievable in a clinical range, b) inhibiting toxin production, c) neutralizing C. difficile toxins by inhibiting the cysteine protease domain, d) inhibiting spore formation, e) inhibiting IL-8 release and protecting cells from effect of toxins, f) preventing intestinal colonization of VRE, and were g) superior to drugs of choice in in vitro testing. The fact that auranofin has been granted orphan-drug status from the FDA for treatment of intestinal amebiasis, and is currently in a Phase II clinical trial for treatment of intestinal giardiasis, further validates our approach. Our overall goal in this application is to further validate auranofin and ebselen as potential treatments for superficial, systemic and intestinal infections caused by multidrug-resistant bacterial pathogensand C. difficile. Our findings in MRSA, VRE and C. difficile will be broadly relevant to other pathogens and may offer a safe, effective, and quick supplement to current approaches for treating bacterial infections.
Drug-resistance bacterial infections have become a serious threat to the global public health due to the dearth of effective antimicrobials. There is no doubt that there is a critical unmet need for a novel antibacterial agent to treat these infections. The proposed research is expected to have a significant positive impact on human health by validating non-antimicrobial FDA approved drugs as antimicrobial agents, which may lead to the development of a new class of antimicrobial drug that can be used to treat infections caused by highly resistant pathogens.
|Thangamani, Shankar; Maland, Matthew; Mohammad, Haroon et al. (2017) Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway. Front Cell Infect Microbiol 7:4
|Hussain, Hafiz I; Iqbal, Zahid; Seleem, Mohamed N et al. (2017) Virulence and transcriptome profile of multidrug-resistant Escherichia coli from chicken. Sci Rep 7:8335


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Bartec Auto ID
A company overviewEnquiries
Link required: https://tools.bartecautoid.com/TPMSDESKTOP/publish.htm
1. User has to press the 'Install' button - Software is downloaded
2. Double click on the downloaded executable - Software is being installed and run(Shortcut installed on desktop)
3. User has to click on "Settings" - System settings menu appears
4. User has to make selections in:
Link required: https://tools.bartecautoid.com/login.aspx
The user has to click on either 'Register' (red banner) or 'click here to register'
5. This then takes the user to: https://tools.bartecautoid.com/login.aspx
where they have to complete his details and click on a 'Register' button.
They will receive a 'Registration confirmation email' with a link that they have to click on so that their email address is confirmed as a valid one.
A click on that link takes you here:
6. The user can then log in with their user name and password and is taken to the 'Tools' tab.
7. On this tool tab the user has to click on 'Register a new tool'.
This takes the user to: https://tools.bartecautoid.com/RegisterTool.aspx
8. The user enters the 'Serial Number' and 'Purchase date' and clicks on the 'Register' button.
This is the end of this stage.
The user now has to connect the USB lead from the Tech300 kit with:
After a few seconds the PC will recognise the SD card in the tool as an external drive.
If the application is not currently running, start the TPMS Desktop, using the Short-Cut on the PC's desktop.
Press the 'Update' tab.
The 'Tool management' screen appears, displaying the Tech300 which is connected to the PC with the USB lead.
If the Tool is not displayed, proceed with 'Step E – Press Refresh' below
Press Refresh
Then disconnect the tool from the PC and turn the tool off.
The easiest way for the user to do this is by pressing both the 'Enter' + 'On/Off' keys simultaneously.
The tool turns on and this is displayed on screen:
When you press it, you see:
Then reconnect the tool with the PC.
The 'Current version' of software (57.0) on this tool is older than the one that is currently available, 'Latest version', (58.2).
In the 'Connected Tools' section the 'Update' button is dark grey, signifying it is active.
When you press it, you see:
Press 'Update Tool.'
When the update is complete, you get this:
You can now unplug the tool.

subset: commoncrawl


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I don't think I've met anyone who didn't like doughnuts. Never. I mean, really, have you ever offered someone a doughnut and heard them say, "no thanks, I just can't stand doughnuts." Uh, no. The few times I've heard the offer of a doughnut refused it went something like, "I'd really love to have one, but I'm trying to avoid fried foods." Ah ha! It's always the old fried foods excuse, isn't it? Well, I have the solution for that. Baked doughnuts!
A while back I bought one of those doughnut pans I'm sure most everyone has seen in the kitchen and home goods aisle. I normally wouldn't buy something with such a specific purpose but, well…it was on sale you see and the price was so good. I had every intention of making delicious baked, cake type doughnuts. Really I did. And what did I do? I put that pan away and forgot all about it.
Until… a while back the people at Betty Crocker asked me and a few other bloggers to come up with some creative ways to use a few of their new products. Did you know they have a bunch of new baking mixes on the grocery store shelves? They do! And one of those is a Reese's Peanut Butter and Chocolate Premium Cupcake Mix. What a combination, huh? Chocolate and peanut butter. The unique thing about this baking mix is that it contains a peanut butter filling that is piped into the center of cupcakes after they're baked. Yummy. They even include a piping bag right in the box for you to use. Very thoughtful.
So, to get back to the assignment, it was to use the box mix in a creative way. I was mulling this out loud one day and leave it to BeeBop to always come through when I'm drawing blanks. He said, "how about doughnuts!" Where he pulls these ideas from I'll never know but thank goodness for him! I got that doughnut pan out and put it to work creating these delicious baked chocolate doughnuts. Hope you enjoy them!
Preheat the oven to 350 degrees.
Prepare the cupcake batter by combining the cupcake mix, water, oil, and eggs in a large bowl. Beat on low speed with an electric mixer for 30 seconds. Increase mixer speed to medium and continue beating for 2 minutes stopping to scrape down the sides of the bowl occasionally.
Fill the cups of a doughnut pan 2/3 full with the cupcake mixture.
Bake 10 minutes or until a toothpick inserted comes out clean. Cool for 5 minutes in the pan then remove the doughnuts to a wire rack to cool completely (about 30 minutes).
Meanwhile, make the peanut butter frosting. Combine the peanut butter mix with the softened butter and cream (or half and half, or milk). Stir until the mixture is well blended and smooth.
Dip the top of each doughnut into the peanut butter frosting and place back on the rack, frosting side up.
Sprinkle with your choice of garnishes. I used mini chocolate chips and white chocolate chips. Mini marshmallows or sprinkles would be fun, too.
Enjoy! All text and photographs on Never Enough Thyme are copyright protected. Please do not use any material from this site without obtaining prior permission. If you'd like to post this recipe on your site, please create your own original photographs and either re-write the recipe in your own words or link to this post.
Baked Chocolate Doughnuts with Peanut Butter Frosting
All text and photographs on Never Enough Thyme are copyright protected. Please do not use any material from this site without obtaining prior permission. If you'd like to post this recipe on your site, please create your own original photographs and either re-write the recipe in your own words or link to this post.
Other baked doughnut recipes you might enjoy from around the internet:
- Baked Cinnamon Sugar Doughnuts from Shutterbean
- Baked Blueberry Doughnuts from Weelicious
- Baked Eggnog Doughnuts with Eggnog Rum Glaze from Savory Simple
- Brown Butter Baked Doughnuts from Joy the Baker
- Baked Pumpkin Donut Holes from Two Peas and Their Pod
- Baked Red Velvet Doughnuts from Taste and Tell
What I was up to…
- One year ago: Chicken, Bacon, and Mushroom Sandwich
- Two years ago: Country Ham with Red-Eye Gravy
- Three years ago: Pickled Okra
- Four years ago: Chicken Cacciatore
I'm required by FTC rules to disclose to my readers that I am being compensated by Betty Crocker for my work on this post. A girl has to pay the bills, you know. But anything I say here is 100% my own opinion. Always has been, always will be.


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A large stag has been locked in a park overnight after spending its third day on the loose near Croydon town centre.
People have been warned to stay out of Park Hill recreation ground for their own safety and to protect the red deer, which made its way to the town along nearby railway tracks.
Police and the RSPCA sent officers to the park this morning, although the red deer was reportedly first sighted on Wednesday.
Network Rail are understood to have opened a gate to allow the deer into the park after it was spotted on a steep bank near East Croydon station.
The gates of the recreation ground, which is surrounded by busy roads and residential streets, have been locked to contain the stag and keep the public out.
The stag takes a peek at his observers (photo: Ivo Petya Delgyanski)
Croydon Council said it was in discussions with a deer farm about relocating the stag and that the park would remain shut "until further notice".
Intrigued observers have been drawn to the park's gates to try to catch a glimpse of the deer.
Robert Rudman, 40, brought four-year-old son Donovan to see the animal this afternoon.
He said: "My dad told us about it so we thought we'd come and have a look. It's fascinating.
"How it got here I have no idea, but it's magnificent to see."
The council erected notices on park gates warning people to stay out and to keep dogs on leads.
One of the signs said: "A large red deer is loose in the park. For your safety and the welfare of the animal do not enter the park nor attempt to get close to the deer. It is a wild animal and should not be approached."
It added: "The deer arrived safely of its own accord and in time will leave safely. We will do all we can to keep him safe."
The stag had been distressed by people trying to take pictures of him, a council spokeswoman said this morning.
Wild deer are often sighted in the grassy southern fringes of Croydon, but it is rare for one to venture so close to the town centre.
Have you seen the deer? Call the newsdesk on 0208 822 7351 or email firstname.lastname@example.com


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The Best Herbs for Composting
Need to get much more vitamins into your compost? Effectively, take into account including herbs. In fact, herbs gained't kind the vast majority of your compost pile, however are a welcome addition for the advantages they carry. Consider them as you do herbs in cooking – as a bit addition so as to add some additional zing. Under are some herbs that make nice dietary supplements to your compost, however first you want a compost pile so as to add them to.
Get the Fundamentals Proper
Earlier than you get to the herbs, you could get the fundamentals of your compost sorted. You'll want straw, wooden chippings, pruning and branches – you're carbon-providing components and may kind the majority of your compost. You'll additionally want inexperienced backyard waste, like grass clippings, leaves and weeds. Add kitchen scraps, some soil, manure and shredded paper, hold moist and switch repeatedly, and you've got the right situations for micro organism and microorganisms to interrupt down the fabric and create nutrient-rich compost. Including herbs will each assist the decomposition course of and get extra vitamins in there.
Comfrey is a nutrient powerhouse. It has very deep roots – typically stretching down so far as ten ft – which means that it could entry a whole lot of vitamins within the soil. It then shops these in its massive, furry leaves. When the comfrey plant is minimize, these leaves break down very quick. Which means that comfrey works properly as a 'minimize and go away' mulch, however may be much more useful when added to the compost pile. The big quantity of vitamins comfrey provides boosts the decomposition price and serves to counterpoint the entire heap. (It's notably good for 'kick beginning' a brand new compost pile.) It additionally has a excessive carbon to nitrogen ratio, making compost that has comfrey in excellent for vegetation. For those who have been solely going so as to add one herb to your compost, you'd most likely make it comfrey.
Like comfrey, borage produces a whole lot of biomass above the bottom, so is a perfect crop to develop for composting or mulch. An environment friendly fixer of nitrogen – absorbing the ingredient from the air and storing it of their root nodules – borage can also be a wonderful supply of zinc and potassium, each necessary for plant development.
Yarrow is a helpful plant within the floor. It's notably properly suited to planting in a guild with fragrant herbs, equivalent to thyme, rosemary and basil. The proximity of the yarrow appears to assist improve the manufacturing of important oils within the herbs, making them extra resistant to break by bugs. The herbs additionally profit for the excessive stage of nitrogen in yarrow, and it's this that makes it splendid for the compost pile. Unattended, yarrow can unfold rapidly, so minimize and prune repeatedly, and add the clippings to your compost.
Dandelions are powerhouses in the case of minerals. They comprise good ranges of iron, calcium, phosphorus, magnesium, and copper, so composting them makes a whole lot of sense. They're additionally blessed with a whole lot of silica, which vegetation use to construct sturdy cell partitions, and potassium, which they retailer of their roots. Returning all these vitamins to the soil will make your vegetation sturdy and productive.
Nettles are one other good plant to assist get a compost pile going. That is primarily as a result of excessive ranges of nitrogen that they comprise. However that's not the one nutrient they carry to the combo. Nettles are excessive in phosphorous and iron, which is crucial for the formation of chlorophyll in vegetation.
Chamomile could also be a relaxant when brewed in tea, however added to a compost pile, it actually will get issues going. Chamomile comprises good ranges of calcium, which helps the cell partitions of vegetation develop properly and helps them take in nitrogen. It's also a great supplier of sulfur, which is without doubt one of the macronutrients important to wholesome plant development. Sulfur promotes enzyme exercise, improves root and seed manufacturing, helps vegetation develop proteins and improve their skill to withstand the chilly.
Compost piles love lovage. It's because it supplies excessive ranges of two of a very powerful vitamins for plant development: nitrogen and phosphorous. Including lovage cuttings to your compost pile will give it actual increase, notably within the early levels.
Whereas fennel provides a beautiful piquancy to meals when used within the kitchen, within the compost pile it's no much less dynamic. In addition to numerous potassium, fennel can also be a great supply of copper. This hint ingredient helps vegetation reproduce, so getting some into your compost will assist improve the productiveness of your backyard.
This hardy perennial of an herb is sweet for including to a compost pile as a result of quantity of potassium concentrated inside it. One of many vitamins that vegetation take in essentially the most of, potassium builds protein, helps with the method of photosynthesis and is necessary in enabling vegetation to fight illness. This large dose of potassium makes tansy, like lovage and comfrey, a great 'accelerator' to your compost pile, dashing up decomposition by the microorganisms.
One to Keep away from: Recent Mint
When you have a whole lot of mint that you just wish to recycle, including it straight to the compost pile isn't the easiest way to go about it. Mint is a herb that's famend for its skill to colonize areas and added to the compost pile it's prone to result in it rising and infiltrating the compost. Then, whenever you unfold the compost in your beds, the mint will achieve a foothold and unfold like wildfire, which may be detrimental to different vegetation. The very best factor to do with areas of mint you wish to do away with is sheet mulch excessive. In case you are unable to take action, you may add mint cuttings to compost however provided that they're useless. Both place them in direct daylight or wrap in a plastic bag to deprive them of sunshine, and in per week or two they need to be okay to compost.


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Using a compound crossbow in hunting was something I had done well before getting into prepping. Because of my local laws, owning a crossbow or an air rifle is much easier than having a real firearm. I have had tried a number of different crossbows and have stuck with the CenterPoint Sniper Crossbow because of its great 4x32mm scope, its 370 feet-per-second speed, adjustable stock and a very easy drawback.
People in the disaster preparedness community often say they are readying for the "shit hits the fan" moments: some future calamity, however plausible or implausible, when we are forced to fall back on our possessions and ingenuity. Doomsday Preppers, the long-running National Geographic show that popularized the term "prepper," introduced mainstream America to a slew of quirky individuals — mostly men with a love of pricey gadgets and the Second Amendment — and the highly improbable doomsday scenarios for which they'd chosen to prepare.
The present disambiguation page holds the title of a primary topic, and an article needs to be written about it. It is believed to qualify as a broad-concept article. It may be written directly at this page or drafted elsewhere and then moved over here. Related titles should be described in Survival, while unrelated titles should be moved to Survival (disambiguation).
I was going through a bunch of things I'm either looking to buy or that others were asking about and thought you migh be interested in knowing which prepper and survival gear is selling better than the rest. It's a great indication that what you're buying is a good value, and you can always read the reviews to see if you should buy it. This is currently the list of the top 10 best-selling prepper and survival gear items, along with an explanation for each.
Anarcho-primitivists share many characteristics with survivalists, most notably predictions of a pending ecological disaster. Writers such as Derrick Jensen argue that industrial civilization is not sustainable, and will therefore inevitably bring about its own collapse. Non-anarchist writers such as Daniel Quinn, Joseph Tainter, and Richard Manning also hold this view. Some members of the Men Going Their Own Way subculture also promote off-grid living and believe that modern society is no longer liveable.[107]
When it comes to survival and preparedness, it's true that there's strength in numbers. But there are some preppers you don't want to hitch your wagon to. In a survival situation, these people are sure to drag you down, and maybe, even put you in danger. These are the ones who make rash decisions, don't take prepping seriously, crack under pressure, or just flat-out don't know what they're doing. Have you met someone from these prepper categories before? In this article, we'll cover some of the most common preppers you should avoid and tell you how to avoid them. Check out the list below to have a more efficient prepper life.
Luther's decision to build up a pantry, she says, did more than help the family get by on a tiny budget. Later on, it would also help her through a divorce, the sudden death of her ex-partner at age 40, and getting laid off from two jobs in the automotive industry in the late 2000s. "I feel that it's the whole reason my my mortgage didn't go into default when I was unemployed, because I didn't have to go to the grocery store and buy stuff," Luther says of her experiences during the recession. "All the limited amount of money I had could go to paying the mortgage and keeping a roof over our head."
In both his book Rawles on Retreats and Relocation and in his survivalist novel, Patriots: A Novel of Survival in the Coming Collapse, Rawles describes in great detail retreat groups "upgrading" brick or other masonry houses with steel reinforced window shutters and doors, excavating anti-vehicular ditches, installing warded gate locks, constructing concertina wire obstacles and fougasses, and setting up listening post/observation posts (LP/OPs.) Rawles is a proponent of including a mantrap foyer at survival retreats, an architectural element that he calls a "crushroom".[7]
Over the years, I've had many requests to create a book about a simple guide to being prepared. Readers wanted a preparedness formula they could share with their friends and family. They also wanted a way to see how they measured up as a prepper. Prepper Supplies Checklist is designed to meet that request. It's a quick 20-minute read workbook, but if you've got the prepper mentally, you may find yourself taking inventory of all the supplies in your home (in which case it is a little more of a time investment). Don't judge a book by its length. This book is loaded with resources and information that will have you looking at your supplies in a new light and spark life into your preparedness efforts. Prepper Supplies Checklist is a workbook designed to help the user develop an emergency preparedness plan. It is presented in an easy to read format that includes stories, photos, illustrations, helpful tips, and some great survival gear ideas! Each section can help you evaluate the supplies you currently have available, the location of supplies, provide ideas on items you may potentially lack, and checklists to measure progress toward your preparedness goals.
Say what you want about the "characters" involved in the various episodes, but the bottom line is this - are you prepared? Likewise, do you have any friends or colleagues who you have bounced ideas off to create and assemble your emergency reaction plan? Probably not, is my guess. On the other hand, with these videos, you can extract the good and bad, the essential and non-essential, and develop your own plan. The program presents 2-4 different groups of individuals in each episode with a different crisis focus. For example, some preppers focus on EMP (Electronic Magnetic Pulse) disasters, other focus on the results of an economy meltdown, others on natural and man-made disasters. In any case, the concept each prepper conveys is the Boy Scout motto of "Be Prepared". My thinking is that anyone who watches this series (at least this 1st season) will have a better chance to formulate their own ideas of whether making any emergency plans is worth their while. And if so, it's quite easy to filter through the sometimes odd personalities who've made the show what it is. Thing is, after an emergency, the issue of odd personalities will be a moot point. As they say, would you rather be six months too early or one-day too late in your emergency planing? My thinking is that everyone should analyze their own exposure to disaster (e.g., hurricanes, storm surges, tsunamis, nuclear radiation leakage, earthquakes, floods, and of course the darker concept of whether or not these United States of America will always be acceptably free and that our way of life will never be challenged). In any case, be prepared, patriots.
1. Something else to consider is a smart phone. My phone has a 32gig memory chip. It can holds LOTS of info. Some paperback books will be good to have. But even off the grid a phone can still access certain apps that have been downloade. I have about 50 books on my phone. A compass. Maps. I can draw a quick map or list with my stylis too. I can easily share documents and file by just tapping my phone on another smart phone. Take pictures and zoom in on them. Great to check progress walking and general references.… Read more »
Survivalists' concerns and preparations have changed over the years. During the 1970s, fears were economic collapse, hyperinflation, and famine. Preparations included food storage and survival retreats in the country which could be farmed. Some survivalists stockpiled precious metals and barterable goods (such as common-caliber ammunition) because they assumed that paper currency would become worthless. During the early 1980s, nuclear war became a common fear, and some survivalists constructed fallout shelters.
They looked at data for the local population over various periods of growth and change, and found that the entire central Mesa Verde area was depopulated by the early 1280s, says Kohler. Based on tree-ring data, the team knew that there was a long cold spell in the 1200s. By the time a great drought hit from 1276 to 1289, most people had already left the region.
But even if the two sides reach an accord, it would still need approval from Parliament, where hard-line Brexit supporters in Mrs. May's fractious Conservative Party are threatening to wreck any agreement because of her proposal to keep some close economic ties to the bloc. Instead, they want a much cleaner break, with some insisting that there is nothing to fear from a no-deal Brexit.
A portable, 2.6 pound stove fueled by naturally occurring scraps sure would come in handy after society breaks down. Voila: the BioLite Camp Stove. Feed it biomass like twigs, pinecones, or wood pellets, and the resulting smokeless fire from this portable grill can get a pot of water boiling in under five minutes. It also generates enough electricity to charge a mobile phone or other gadgets with a USB port. Included is a USB-charged FlexLight, a light with bendable stem that can be positioned to illuminate the cook surface.
The increased inflation rate in the 1960s, the US monetary devaluation, the continued concern over a possible nuclear exchange between the US and the Soviet Union, and perceived increasing vulnerability of urban centers to supply shortages and other systems failures caused a number of primarily conservative and libertarian thinkers to promote individual preparations. Harry Browne began offering seminars on how to survive a monetary collapse in 1967, with Don Stephens (an architect) providing input on how to build and equip a remote survival retreat. He gave a copy of his original Retreater's Bibliography to each seminar participant.[citation needed]
Doomsday Preppers explores the lives of otherwise ordinary Americans who are preparing for the end of the world as we know it. Unique in their beliefs, motivations, and strategies, preppers will go to whatever lengths they can to make sure they are prepared for any of life's uncertainties. And with our expert's assessment, they will find out their chances of survival if their worst fears become a reality. Season 1 includes Bullets, Lots of Bullets, I Hope I Am Crazy, Back to the Stone Age, It's All Gonna Hit the Fan, Friends Can Become Enemies, Nine Meals Away from Anarchy, Into the Spider Hole, It's Gonna Get Worse, Close the Door, Load the Shotgun, Disaster Doesn't Wait, I Suggest We Run, and bonus program, American Doomsday.
Newer innovations have allowed mobile phone users to still communicate in recent floods using the GoTenna devices, which are paired with mobile phones to create their own mesh network and communicate without needing a phone signal. These are much more limited in range than HAM radios though and only have a 5-7 mile reach. It is possible to send a message further but that would have to be through the meshing or 'hopping' through these devices.
Good afternoon all, I hope some of you are enjoying this Rivalry College Football Saturday. Anyway, I am about to conduct some bulk ammo accuracy testing of Federal American Eagle .223 55 grain, XM-193, and XM-855 (I do not like putting steel case through my rifles not designed for it). Testing will be done through a Ruger AR556 (16.1" barrel, 1:8 twist) with a Leupold 1.5-4x scope. I will run tests of 50 rounds of each ammo, on 3 different occasions to vary temperature and atmospheric conditions at 100 yards starting with a different ammo first on each different occasion so a different ammo type has the cold barrel advantage. Anyway, to anyone who is interested, I will be posting the results after each trial.
What's the bare minimum you need to navigate across land? For most people, that would be a compass and map. A basic road map is sufficient to get a rough approximation of the lay of the land. More detailed relief maps can help plan for elevation and estimate possible water sources but they also take up more room in your pack. Waterproofed or laminated maps are also extremely helpful. Lensatic compasses are the most reliable for little money. If possible, a compass and protractor are also extremely helpful for route planning. Obviously, not as essential but nonetheless useful.


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Proceedings of the 2012 International Conference on Automobile and Traffic Science, Materials and Metallurgy Engineering
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Research on Combustion Characteristics and Performances of an HCCI Engine Fuelled with Methanol
Han WU, Chunhua ZHANG, Jiangru PAN, Yangyang LI
The impacts of engine operating parameters, including intake charge temperature, fuel-air equivalence ratio and engine speed, on methanol HCCI combustion and performances were investigated on a modified diesel engine. The results show that the intake charge temperature is the most sensitive parameter...
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A Study on Control Strategy under Tip-in Condition Based on AMT Vehicle
Yang Gao, Yong Chen, Daguo Luo, Wenzhong Liu, Mingqi Gu
The control strategy of gear-position optimization of an AMT vehicle under Tip-in condition is presented in this article. The down-shift principle of an automatic transmission under an acceleration condition is also analyzed. The in-the-loop simulation platform of transmission system software of an AMT...
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Dynamic performance of a pure electric vehicle experimental analysis
Tan-li WANG, Chang-hong CHEN, Shi-zhan GAO, Xing-quan LI, Ying-xiao YU
On the basis of analysis of the slop and accelerate inertia force affect on the driving force, this paper propose a calculate method of the maximum driving force and gradient based on the acceleration of the flat road and slop. The result show that the proposed calculate method of electric vehicle maximum...
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Study on the Method of Fatigue Test Loading Spectrum of the Connecting Rod in Diesel Engine
Qing-guo LUO, Xu-dong WANG, Geng-yun ZHANG, Feng WANG, Shu-sheng BAI
Based on flexible multibody system dynamic theory, founded the rigid-flexible coupling multibody dynamic analysis model of the crank and connecting rod mechanism of diesel engine which included the piston, link, crankshaft and flywheel. The dynamic stress of the connecting rod was calculated and counted...
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Research on the Optimization of the Transportation of the Hazardous Materials
Fengrun Guo, Weidong Liu, Wentao Han, Wei Yu
Many ways may be available to transport the hazardous materials. However, different ways will lead to the difference in the cost of transportation and loss of total social expectations. Under the same condition, this paper studies the best way and path to move the materials of danger. It explains the...
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Diagnostic testing and analysis of Independent ignition system based on the Volkswagen 1.8T engine
Wen Fang, Linfu Zhou
According to fault diversity of independent electronic ignition system based on the Volkswagen 1.8T engine, analyzed Sagitar circuit structure of single-cylinder independent ignition system. By the Volkswagen detector 6150 and BOSCH FSA740 analyzer equipment, used diagnostic methods of Volkswagen independent...
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Coordinate Signal Control in Urban Traffic of Two-direction Green Wave based on Genetic BP Neural Network
Shaojiao Lv, Chungui Li, Zheming Li, Qingkai Zang
To maximize the bandwidth of green wave of trunk road is a main issue in the research of signal control in urban traffic. However, the traditional analytical algorithm can not be applied in actual traffic widely. A novel dynamic two-direction green wave coordinate control strategy was proposed to overcome...
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Research on Impregnation Coatings for Protecting Concrete
Wenjuan Gu, Banggui He, Jike Liu, Jie Li
The protecting of concrete, which consists of coating a chemical substance onto concrete's surface, has been applied to architectural conservation. There is increasing interest in studying materials for concrete which can reduce the infiltration of water and salt solutions and rehabilitate and extend...
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Applied Research on Optimum Dosage of Flexible Waterproof Material for Bridge Deck
Fenglan Bian, Younian Dou, Haiquan Cai
The dosage of bridge deck waterproof material can influence not only the road performance but also the construction cost of waterproof layer. The bond strength, shear strength and pull strength of different bridge deck waterproof material dosage are tested to determine the optimum amount. The method...
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Research of the Assessment for Agricultural Machinery Driving Safety Based on AHP-FUZZY Method
Wenlong Chen, Wentao Han
In order to realize the assessment of agricultural machinery driving safety, the key factors of influencing agricultural machinery driving safety were selected and an indexes system of agricultural machinery driving safety assessment was built up. Based on AHP-FUZZY, the assessment weight coefficients...
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Study on Analysis of Chenghe Fly Ash and Preparation of molecular sieve
Jianli Yang, Meili Du, Xiaogang Yang, Renshan Li
In recent years, with the rapid development of coal industry, a large number of coal fly ash has been produced, while the recycling rate of the ash is rather low. It is not only a waste of the precious land resources, but also makes environment suffering severe pollution. As an important kind of new...
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Application of Anchor Spray Combine Arch Rib Reinforce Technology of Stone Arch Bridge
Ruiwei Fang, Xiuzhi Yang
With the development of bridge construction in China, disease bridges became more and more, bridge reinforcement became a important topics facing the bridge workers. Shi-Yan line (S335) Shuigou Bridge is a stone arch bridge of 5-20meter, diseases such as stone arch ring crack, break, endanger the bridge...
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Analysis and Optimize of the Vibration of Mini-Electrical Vehicle Frame
Ruo-xun FAN, Jie Liu, Tan-li Wang, Hong-fei Xue
Geometry model and finite element model of the mini-electrical vehicle frame are constructed by catia and hypermesh. Then, the natural frequency of the lower mode and vibration mode which belong to the electrical vehicle are calculated by radioss. At last, comparing with the excitation frequency of the...
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Reliability Analysis of Railway Signaling System Based Petri Net
Hongxia Chen, Qiang Sun
Railway signaling system is essential equipment for high speed railway and passenger special line, and it play an important role to ensure safety and improve efficiency. Reliability analysis to railway signaling system is necessary and valuable. Railway signaling system is a complex and dynamic system....
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Design and Realization of the Safe Driving Speed Analytical System
Bin Liu
This paper designed the safe driving speed analytical system on the basis of Matlab auxiliary fuzzy control, builds its model of the multi-sensors information fusion. According to the real time monitored temperature and pressure, applying fuzzy control technology, determining of the driving speed security...
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The Control Effect of Traffic Information on Traffic Assignment
Junqiang Guo, Bingzhong Ren
The VISSUM and VISSIM simulation models are setup according to the real road network of Park City, Utah, U.S. The OD matrix is calibrated by the field turning counts. The effects of in-trip real-time information on traffic improvement are studied through microsimulation. Tests have shown that under adaptive...
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Research on Rolling Mill Vibration Based on the Rolling Piece Hysteretic Nonlinear Deformation
Dongxiao Hou, Fei Liu, Haoran Liu, Rongrong Peng, Yue Zhu
The Bonc-Wen hysteretic model was used describe the rolling piece elastic-plastic deformation process performance of hysteretic characteristics, this hysteretic characteristic considered in the rolling process, vertical vibration model of hysteretic nonlinear of the strip mill roll system is established....
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Research On The Estimation Of Lithium Battery SOC Based On EKF
Zhi-sheng An, Zhi-yi Sun, Qiu-sheng He
In the battery management system, the SOC estimation is the most basic and most important part. The exact estimation of SOC can prevent battery over-change or over-change, and extend battery life. Based on traditional SOC estimate algorithm and analysis of factors affecting SOC, the method to estimate...
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A Model and Algorithm for Multi-mode and Multi-route Combined Assignment
Wei Zhu
With development of economy and society, people's travels in China present the multi-mode and multi-route characteristic more and more normally, and the factors of decision-making become more and more various. A kind of model and algorithm with elastic weight for multi-mode and multi-route combined assignment...
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Comparison of the improvement of directional stability for Anti-lock Brake control algorithm
Jing Li, Zihan Wang, Li-shu Guo, Zheng-tang Shi
A nine freedoms nonlinear three-axle vehicle dynamic model was constructed by Matlab/Simulink to analyze the control effect of directional stability for different Anti-lock Brake control algorithm. Algorithms analyzed here contain PID, logic threshold and sliding mode variable structure control algorithm....
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Braking Force Distribution Strategy for Comfort of Tractor and Semi-Trailer Combination
Hongyu Zheng, Zongyu Liu, Wenkai Xu
For the purpose of comfort enhancement during the braking process of tractor/semi-trailer combination vehicles, and in order to achieve a smooth braking deceleration establishment in which the braking force of a vehicle only relates to the braking signal it receives and yet is not affected by the gross...
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The security of medium truck with Engine brake (Jacobs) driving through the mountain highway long downhill slope
Jianbo Wang, Bin Chen, Hengkai Wang, Cao He
In order to solve the problem that the truck should spray water to cool its brake during run the long downhill on mountain highway in winter which can Lead to icy road and cause traffic accidents. We specially selected the straight truck (6×4)which install the engine brake (Jacobs), carrying carry out...
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Study the proneness of long-distance driving accident
Feiyang Ye, Wentao Han
The damages caused by road traffic on people are increasing every year. Among them, the traffic accidents caused by long-distance driving have occupied a large proportion of such problems. So studying the effects of the accident factors on long-distance driving has been as a hot topic by domestic and...
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Evaluation of the Visual Navigation Chart Based on Visual Perception
Hong-yong Wang, Peng Li, Yi-fei Zhao
A complete set of symbols is not formed for VFR chart in our country for the slow development of general aviation. On the basis of the VFR chart collected from lots of designers, evaluation index of VFR chart was defined with the Cognitive semiotics and the demand of chart for VFR. All the sample data...
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Management Measures of Public Bicycle System
Yue MA, Xiao-ning ZHU
Good urban planning can make people have a healthy life style. Otherwise the establishment of urban structure once, wanting to change the impact of urban layout to urban traffic is difficult. When planning, consider walking, bicycle, public transport, car and so on by turn. Give the special opinions...
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Research on Duffing Oscillator Algorithm of Secondary Traffic Accident
Xinglei Zhang, Wenhui Zhang
In order to discover evolution characteristics of secondary traffic accidents and prevent from secondary traffic accidents, chaos characteristics of secondary traffic accidents are analyzed based on describing Duffing oscillator algorithm. Afterwards, chaos model is established. By means of simulation,...
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Investigation and Research on Safety Related Individual Factors of Mountainous Expressway Professional Driver
LinFu Zhou
A sampling survey was conducted on Professional Driver of mountainous expressway in Sichuan Province. The statistical software SPSS 13.0 was used to analyze the survey data in order to know living condition, safety consciousness and driving behavior of Professional Driver of mountainous expressway and...
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Selection of Optimal Third-party Logistics Recycler Based on Fuzzy DEA
Haiyun Zhou, Gang Du, Tong An
Selection of appropriate third-party logistics recycler in closed loop supply chain management strategy (CLSCMS) is a challenging issue because it requires a lot of evaluation criteria/attributes, which are characterized with complexity, elusiveness, and uncertainty in nature. This paper proposes a fuzzy...
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Phase Field Simulation of Dendrite Growth of Fe-C Alloy in a Forced Flow
Xunfeng Yuan, Yan Yang
Based on the KKS model, the phase-field model is built by coupling with the concentration field and flow field, we simulate the dendrite growth during isothermal solidification of Fe-C alloy in a forced flow. The results show that the tip of dendrite arm is parabola shape, the secondary branch appear...
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The Research of the Emergency Rescue Model of the Freeway
Yi Zhang, Yushu Zhang
There are so many people who are injured or dead in the traffic accidents due to not being rescued in time every year in China. Recently, death ratio per 10000 vehicles is 7.4 persons, and death ratio per 100,000 persons of traffic accident is 6.9 persons in China [1]. So the research of the emergency...
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Experimental Study of The Driving-characteristic of Occupational Drivers and Non-occupational Drivers
Cao HE, Bin CHEN, Qing CHEN, Jian Bo WANG
In order to enable non-occupational drivers are better able to participate in road traffic, to ensure road traffic safety and establish the driving guidance method for non-occupational drivers' driver training to provide a more effective way to achieve the purpose of reducing traffic accidents, the random...
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Differential Strategy Research for Vehicle with Motorized Wheels Based on Torque Control
Chuanxue Song, Silun Peng, Liqiang Jin, Shengyi Xuan, Zhu'an Zheng
According to the electronic differential problems for vehicle with motorized wheels, the electronic differential control strategy based on torque control is designed through BP neural network theory, and a suitable BP network is trained with the help of Matlab toolbox. The consistency of both sides on...
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A review of evaluation methods of Visual Guiding Signage's layout in Integrated Transportation Hub
Yuyan Zhou, Enjian Yao
With the rapid expansion of the urban population, urban transportation hub are developing in the direction of large-scale, complex and systematic, the main function of urban transportation hub is to guarantee the effective transfer among different transportation modes. As an important means of passenger...
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Special deceleration strip design of Yaxi Expressway
Qing Chen, Sixia Wang
We elaborate the special deceleration strip design ideas of Yaxi Expressway, put forward the special deceleration strip design plan of Yaxi Expressway. We draw a conclusion that the special deceleration strip of Yaxi Expressway can effectively restrain highway major traffic accidents in the long downhill...
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Evaluation about Passenger Satisfaction Degree of Wuhan-Guangzhou High-speed Rail Based on SPA
Wenfen Zhang, Jiaqi Yang
As far as Wuhan-Guangzhou high-speed rail put in operation, except for holidays, the passenger load rate is low, facing huge market risk. This paper explores the passenger satisfaction of Wuhan-Guangzhou high-speed rail, based on SPA(Set Pair Analysis) theory and combined with practice. To analyze the...
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Emergency Information Extraction of Transport Congestion Based on Object-oriented Classification Using High Spatial Resolution Remote Sensing Image
Tong Tang, Haixia He, Ping Wang
Based on the assumption that road infrastructure information had not been acquired, the road information before and after the emergency transport was extracted by using high spatial resolution remote sensing images. Combined with object-oriented image analysis method, the road and vehicle information...
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Research on Preheating Pulverized Coal to Ameliorate the Blast Furnace Coal Injection
Ran LIU, Chunzhao LIANG, Xingjuan WANG, Shuai FENG
Pulverized coal injection of blast furnace is the important means of lowering ironmaking cost. It is a focus problem to improve the pulverized coal injection rate of blast furnace. However, improve the pulverized coal combustion rate has became a bottleneck of coal injection rate because of the contradiction...
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The impact of contact pressure and road surface character to sliding friction coefficient
Hong-guo Xu, Bin Ma, Cheng Zeng, Yan Xu
A improved sliding friction coefficient model is presented based on road surface character and rubber character to analyze how the road character, tire and contact pressure affect the sliding friction coefficient. Improved the sliding friction coefficient model by introducing the theory of true contact...
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Research on Green Transportation and Transfer System in Urban Areas
Jiang Pan
The green transportation of urban is a need of the society, and it also reflects the advance of city. Moreover, it has played foreshadowing function for the development of tourism industry. Public transport and bicycle/electric bicycle transport are regarded as the main component parts of the green transportation...
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The Analysis of Vibration for High-Speed Train-Ballastless Track-Bridge base on a hybrid FE-SEA method
Wen Jun Luo, XiaoYan Lei, Liang Lian Song
In this study, the methods for combining statistical energy analysis (SEA) and the finite element method (FEM) for the vibration analysis of structures are studied. Using the two methods simultaneously isn't entirely extend a primarily low frequency method, the finite element method, and high frequency...
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Analyzing on post-impact equivalent velocity of the vehicle side-slipping and rotating
Dan Ma, Yongheng Yue
pre-impact speed of the vehicle in the road traffic accident is the important index of dealing with traffic accidents responsibility. We investigate the relation between the road adhesion coefficient and the vehicle side-sliding angle, to constructing adhesion coefficient ellipse equation and then building...
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Study on C/C Composites Ablated in Plasma jet
De-Wen WANG, Yue-Cheng YANG, Bai-Lin ZHA, Yu HU
In order to solve thermal protection problems under atmospheric reentry conditions, some tests on the earth have been done to study antiablative properties of C/C composites in thermal plasma jet. The flow fields and the thermodynamics parameters of thermal plasma have been researched, the parabola distribution...
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Test Study on Slipping Performance of the Flexible Nodes of the Precast Concrete Exterior Wall Cladding Panel
Ruonan Liu, Kaiyin Zhang, Menglan Tao
To explore the performance of the flexible nodes between the precast concrete exterior wall cladding panel and the frame structure, a steel truss is used as an analogue of the frame structure to develop a test. In the test, one precast concrete exterior wall cladding panel was installed on the steel...
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Cylindrical Cam Profile by CMM Based on Pro/E Model
Chao Ma, Bin Wang, Liu Xu, Yan Yu, Ruolei Li
The development of CAD and CAM technology makes it more process to inspect surfaces of the part, this is usually carried out by CMM. With the research of the error analysis of cutter location for unequal diameter side milling of cylindrical cam, the technology using CMM to inspect surfaces by Pro/E CAD...
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Design of Automobile Body Welding Fixture
Liu Xu, Chao Ma, Xia Xie
In automobile industry, automobile welding fixture is component important to auxiliary welding. The automobile body is welded by multiple complex sheet stamping parts and other auxiliary workpiece. In the process ,supporting role of welding fixture is an important step. In this paper, the fixture welding...
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The Mould Management System and Application Based on Agile Supply Chain
Rong Zhao, Liu Xu, Xiaofan Chen, Chao Ma
This article introduced the mold business management informationization superiority and the importance.Then introduced the mold agile supply chain management technology.Proposed a management system. Finally, write out the application of the system.
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Research Status and Development Trend of Dimethyl Ether Fuel Supply System
Jing Sun, Guangde Zhang, Caixia You, Qiang Yao, Zhonghai Hou
A survey of study on dimethyl ether engine fuel supply system at home and abroad was described, including pump-pipe-nozzle system and common-rail fuel supply system. The main trouble of practical application of dimethyl ether engine is wear and leakage problems in the fuel delivery system caused by low...
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Taste of the Town - 2016
Silverado participates in the county's premier culinary event!
On January the 28th, Silverado The Woodlands was a proud participant in the 30th annual Taste of the Town sponsored by The Woodlands Chamber of Commerce. This year the event attracted over 7,000 attendees from across the state and beyond. The attendees sampled mouth-watering appetizers, entrees, deserts, pastries, and beverages from some of the finest establishments in the area and Silverado was proud to be one!
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A Resident Shows Her Artistic Talent on a Holiday Card
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Testimonial: "You allowed my mother's last three years to be full of dignity.."


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I'm confused by the "Breakdown Table" we're seeing when monitoring our non-web ruby application (here: https://rpm.eu.newrelic.com/accounts/2207947/applications/3926618/transactions )
We have instrumented our code with a transaction and within this, a few different custom segments. Our transaction block is called "Datapipeline::RunProcessor/ingest_one_record". So I select this at the top-left (high level selection) and this reveals graphs and a breakdown table for timings within it.
I don't understand why "Datapipeline::RunProcessor/ingest_one_record" then appears within in the breakdown (as "Other transaction" in the left most column). Or if it does appear in there, how can it be less than 100% of the time?
Then I've got two custom segments (
trace_execution_scoped blocks in the code) called "handle_updated_record", and "handle_created_record", which are at a high level decision point in the code. It's either processing one or the other in each transaction, so… I'm expecting those timing to be adding up to almost 100%.
And then for example "Company/Aggregate_relationship_objects" is one of my lower level custom segments. I'm interested in what percentage of time is spent in that, including time spend with database queries within that.
But I'm seeing lots of these database segments with names like "MySQL Placholder find". These could be useful for capturing otherwise unidentified execution timings, but if my Aggregate_relationship_objects method is querying Placeholders table, will that time be included within "Company/Aggregate_relationship_objects" (useful) or "MySQL Placeholder find" (not useful) or both?
I guess it can't be both because I notice the whole breakdown table adds up to 100%. This means it's not taking account of nested timings in the way I'm expecting. When I drill down into an individual sampled transaction, the nesting comes out correctly, and all makes sense. I see "Datapipeline::RunProcessor/ingest_one_record" taking 100% , within that "handle_updated_record" taking 99% , within that "Company/Aggregate_relationship_objects" sometimes taking ~45% and within that various database calls happening.
…but I'm not sure I'm seeing properly how much time "Company/Aggregate_relationship_objects" is taking in the breakdown table.


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Single Family Detached
- 4 beds
- 2 baths
- $219,900 price
- B1155385 mls id
- Square Feet: 2,021 sqft
- Year Built: 1960
Owner for past 40 yrs welcomes you to beautiful 4 bedroom home, positioned in quant cul de sac, complete with sidewalks. Foyer entry leads to abundance of natural light, gorgeous hardwoods, & family room with gas FP. Enjoy formal dining room, eat-in kit area, + breakfast bar. Corian kitchen has vaulted ceilings, skylights, recessed lighting & under-mount sink. Custom pantry with swing-out storage. Full bath has 7.5-foot long countertop. Generous master bed with double closets. Updated half bath with backsplash. Tear-off roof 2016, updated electrical & concrete driveway/sidewalk. Huge fully fenced yard with 20x15 stamped concrete patio. Vinyl replacement windows. Showings start immediately.
- Site Link
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Single Family Detached
2 Pictures
Solid, 4 Bdrm, 2FB Cape in Williamsville School District, on a deep, park-like lot. Has so many great features; open floor plan, updated kitchen w/SS appliances (included), new flooring being installed in living room,& dining room & super convenient first floor laundry off of kitchen....
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Updated 4 bedroom 2.5 bath ranch. Updates include kitchen & bathroom 2018. Large master bedroom w/full bathroom. beautiful hardwood floors. Home is in a great location and a pleasure to show.
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30 Pictures
Fully updated 4 bedroom 1.5 bath Colonial fully fenced on private street in Williamsville. 2018 new kitchen, solid surface countertops, sump pump, back up sump pump and battery, hot water tank. 2017- 25x14 concrete patio, 12x14 shed, 25x14 composite deck, front sidewalk garbage disposal, fully...
MLS ID b1161213
4 beds, 2 baths, 1,594 sqft, $219,900
Courtesy of: HUNT Real Estate ERA
Office Phone: +16073244022
Listing Agent: Amber Martinez
Updated: 19th February, 2019 6:10 PM.
46 Kim Circle Amherst, NY


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After a long time again, hope you all are fine.
I'm going to write what I came across few months back while I visited a Meditation Center namely Brahma Kumaris in India. Along with a friend I had good experiences which I'm going to share with you.
Today most of the problems in relationships occur due to the common 'expectation' we have for the other person. The other person can be your husband/ wife/ boyfriend/ girlfriend/ parent/ friend/ sister/ brother. Anyone close.
Sadly, with those we are close and ironically that too, we shouldn't be expecting much. You might relate to quotes you see like 'Expect little, give much' and so on. Well, its true. A relationship is formed in the mind.
Ask me how? I tell you.
Read carefully, a relationship is something which is 'formed' when two people 'give'. I give, you give. It's that simple and its formed. Then attachment happens and slowly you share things with the other person.
Now to maintain the relationship it is very vital to remember that you should concentrate on giving without expecting much.
Sit back and think about it. When was the last time you selflessly did something for the one you love and they appreciated? How did that make you feel?
Now you might have negative thoughts creeping in like 'Oh I did so much but i got very little' or something like 'I'm disappointed'. Ask yourself why?!
Let me tell you, if the relationship you are relating to right now while you are reading this is about 'love', then love is supposed to be completely unconditional. Unconditional acceptance of the other person.
If you are facing problems in your relationship try the method of being more loving and caring no matter what you receive from the other end. Have patience, keep faith. This unconditional love has the power to get the person back into your life or solve the problems now or in the future.
Love is within us, its our very core with which we are made. We are human 'beings' after all. Aren't we supposed to be better than animals who just reproduce but not socialize?!
Similarly, a human being is supposed to give, the other will give too. If however you think that you have given enough positive energy to the other person and it is simply not working then maybe you can go back in time and ask those questions of what went wrong. Somewhere it is our fault that we do not recognize or are too 'egoistic' to accept our mistake.
Keeping a relationship healthy is very simple:
Step 1. Be Positive.
Step 2. Remember to give and to share.
Step 3.Trust wholeheartedly, no matter what. If they betray, accept it as your choice to trust, do not blame them.
Step 4. Don't try to change the person as that means we are Not accepting him or her. If we don't accept, we are sending negative vibes which leads to more misunderstandings.
Step 5. Accept yourself as you are and concentrate on being more loving and caring.
May Peace be with you.