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Vanilla Bean
Vanilla Bean is an outgoing and affectionate girl. This rare beauty is very quiet. She keeps your secrets safe! She will seek attention and affection from you, hoping to become your favorite friend and confidant. Vanilla Bean is so easygoing that she would be a great first cat. Of course she'd be perfect for anyone who loves and cares for her. She needs someone to love her for who she is and not just how she looks.
Vanilla Bean gets along well with other cats and kittens. She can be adopted by herself if her new family will be home a lot. She gets lonely by herself. She would be happy to have another cat in her new home so she would have company. This sweet girl hasn't been tested with dogs but she did remain calm and non-reactive when she saw my two calm dogs.Vanilla Bean is a mom cat with two kittens.
Spayed/Neutered - Vaccinated - Dewormed - Treated for Fleas
Tested for FeLV and FIV (cats and kittens only) - Microchipped
Kitten Rescue is located in Los Angeles, CA and we only adopt animals to homes in the greater Los Angeles area.
Email foster parent


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The users are raving about it and if you're the type who needs to have the cream of the crop, then there's no better espresso machine out there than the DeLonghi PrimaDonna ECAM28465 . With this bad boy, you'll never have to worry about loss of quality when preparing your favorite coffee drinks, since the PrimaDonna uses high quality internals and sophisticated coffee preparation modes to ensure that you're going to get a delicious cup of your favorite coffee drink every single time with just the push of a button.
As with other Jura machines, the Impressa Z6 is hygienic and conveniently cleans up after itself. The extra large 2.4 L water tank has a handle for easy removing, and is designed to work with a Smart Water Filter, which uses RFID technology to communicate with the control panel about its lifespan, automatically alerting you when it needs changing. Using a filter ensures great tasting coffee and reduces the need for descaling. The Impressa Z6 automatically rinses on start up, and keeps a reminder to clean the milk circuit on-screen when needed. All of the maintenance processes, such as brew group cleaning and descaling, will throw alerts as well, and are easily accessed through the TFT display where they can be performed by pressing a button. Step up to the Giga 5 for a dual grinder, dual boiler machine for high speed brewing and added functionality; or for a smaller machine you can control with your smartphone, take a look at the intuitive, ultra-convenient J6.
Coffee & Espresso Machines - Touch-button convenience, sophisticated styling and customized options like no other. The Jura Capresso Impressa F7 Automatic Coffee Center Espresso Machine creates delicious, perfectly tailored drinks with less preparation time and less noise. The commercial-grade specially angled internal coffee grinder is now twice as fast. With the full programmability of the Jura F-line, the espresso maker customizes your coffee - all with automatic or push-button ease and without even moving the cup. The high performance 18-bar pump with 1,450-watt stainless-steel lined Thermoblock heating system ensures fast, energy efficiency. Espresso maker's 10-digit LED display dialog system shows brew strength and cup size while brewing. DualFrother PLUS smoothly froths and steams milk of the finest quality and consistency. Sleek, symmetrical design fits in any kitchen or office, right under the cabinet. Product Features 18-bar pump with 1450-watt stainless-steel lined Thermoblock heating system for fast, - Specifications Made in Switzerland Material: ABS, polypropylene, stainless-steel, matte chrome plating Model: 13709 Capacity: 64 oz. Watts: 1700 / 110 Volts Size: 11" W x 17.5 D x 14" H Weight: 25 lb. Use and Care Housing wipes clean with damp cloth. Rinse and refill water tank daily. see more...
The Gaggia Anima Deluxe's pre-infusion feature is a huge hit with coffee aficionados, as the pre-soaking enhances coffee's natural flavors and aromas. Its beautiful design looks at home in the modern or traditional settings, bringing the look and feel of a European cafe to your home. The simple user interface combines manual buttons and digital display for foolproof brewing.
If you are going to try to make other coffees with this machine, plan on doing some trial runs to get it right. Since you can adjust the amount of water and beans, you can make standard coffee if you want, but it's not going to be as good as the espresso. Overall, we only recommend this to espresso drinkers, but it's nice to know that you can make other beverages if and when you want a change.
Turn, press, enjoy – that's how easy it is to enter the world of IMPRESSA C65 With the one-switch operating concept of the Rotary Switch and the 11-language plain text display, it's easy to create the perfect coffee every time. Thanks to the high-performance conical grinder, the beans are always freshly ground. The simple, compact design with its elegant combination of matte and gloss black gives the IMPRESSA C65 an imposing yet understated look in any surroundings.
The ESAM3500.N features programmable menu settings, meaning that you can easily adjust the coffee temperature, water hardness, the 1h to 3h automatic shutoff, start time and clock. Regardless of how picky you may be when it comes to coffee, you'll definitely get to prepare a delicious cup of your favorite blended thanks to the 5 settings for coffee strength, including extra strong, strong, regular, mild and extra mild. On top of that, there are 3 buttons which make it easy to choosing the cup size (large, espresso and ristretto).
Semi-automatic espresso machines are just that—semi-automatic. Some of the steps are automated, but many are not. This allows the user to put their personal stamp on the final product but without doing some of the tedious steps that are involved in making an espresso on the stove top. Here's a look at some of the features that make a semi-automatic espresso machine such a great pickup for the ultimate espresso lover:
My first Jura was the F7. I bought it off of Ebay(new) and couldn't have been happier. I was so thrilled with it, that I bought another (F9) and gave my mom the F7 because it was such an awesome machine. It is really remarkable how the machine works. It took me a good 15+ cups to figure out how to make the coffee the way I like it. There are so many options on this machine that effect the taste: Grind, water temp, quantity of beans, quantity of water, etc.... In reference to the service I am amazed. When I received my new F9, I immediately had problems with a couple of the buttons. I called the service center and was on hold for 6-8 minutes. After about a 2 minute conversation with the representative they said that she would just send out a new machine and when I get it to send my old machine back in the box. They paid all postage. No credit card, nothing. I've never heard of such a service before. Absolutely Excellent. I couldn't be happier. It is a great machine that makes very good coffee and looks really nice on the kitchen counter. I love my Jura! As a matter of fact, I believe I am going to go and make myself a decaf latte right down.
The Aroma G3 grinder uses conical steel burrs and six degrees of fineness to grind quickly, thanks to the perfected cutting angles that produce 60% less residual grounds. The result is a quieter grinder that preserves more of the flavor and aroma of the freshly ground beans while operating twice as fast. An integrated bypass doser allows for pre-ground coffee brewing.
One of the things that makes Jura such a world-renown coffee company is that their machines are so easy to use. As long as you have beans, water, and milk in the container, all you have to do is push a button and wait for the perfect cup to arrive. In this case, the Impressa F8 is one of the more technologically proficient models, thanks to its TFT screen.
Espresso is the strong, yet delicious drink that most of us love to have every morning, not only because it "wakes" us up, but also because of its incredible taste. However, the truth is that buying a cup every day can easily start taking a toll on your budget, so that is why it's best that you consider getting an espresso machine so you can start making it right at home. No matter how you like your espresso, after reading the following automatic espresso machine reviews, you'll know exactly which machine you should get.
This hefty Capresso burr grinder is built with a heavy-duty zinc die-cast housing, making it sturdy and reliable. Its large 8-ounce hopper ensures that you won't be refilling your coffee beans for days. Its burr grinding mechanism produces consistent, uniform grinds in 16 different texture settings, from Turkish at the finest to French press at the coarsest. Because the Capresso 565 has a low RPM, low-heat grinder design, it causes minimal degradation to your coffee beans.
The sleepyheads in your house will love the 8 profile feature, which saves up to 8 drinks per person for an easy, fool-proof brew every time. Simply select a profile and the desired drink for an easy brew even when you're half asleep! Or select from one of 17 pre-programmed recipes, all available at the touch of a button on the one-touch digital screen.
The machine is very nice looking in person, very sleek. The instruction manual is pretty sparse on details. It has enough, but it's a little intimidating for a first time user. I took my time and found out that the programming is very user friendly and easy to use. I have ours on our counter with a cabinet overhead. When I fill water reservoir I do pull the machine a bit forward because the reservoir is deep and you have to lift it straight up. It's easy to do but you need a bit of clearance. The bean hopper is in the back, so I pull the machine forward a bit to fill that, as well. Very easy to do. One thing I wanted in the J9 was the option to use a water filter. I have hard water from our tap, and had been filling our DeLonghi from our filtered refrigerator dispenser, but that was cumbersome. With the Jura filter I can fill the deep reservoir right in the little bar sink I have next to the machine. I tested the water before and after, and the Jura filter definitely works to reduce hardness, which is important in keeping the machine free from mineral scale buildup. I think it will be well worth the expense of replacing the filters. It came with one filter and a couple of descaling tabs, which I have not had to use yet.
That's a pity because as auto-frothers go, it's a very good one. The one thing we're not so crazy about is the fact that you've got to run plastic tubing from your milk source (you have to provide your own, by the way – you do not get one when you purchase the machine) to the frothing arm, which makes your very expensive coffee machine look like a high school science project.
We're going to start with a rundown of the features of the Impressa F8, so that you know what you're getting if you choose to buy. A lot of machines offer the same core functions, so we tend to focus on what stands out, so rest assured, if we rate a machine highly (as we do with this one), it's going to be a good all rounder unless we specifically say otherwise.
THE CURE: Once weekly reach up inside with a hot, wet towel, and clean the round disk behind the flap that hangs down. If it jams, unplug and let it cool before turning it on - sometimes you may have to do this several times. It just happened this a.m., and I had to wait 1/2 hour between my 3rd and 4th cup :) The first time it happened, tech support walked me through the cleaning on the phone. The last time was more of a problem, and they shipped me a mailing label for a $245 complete rebuild, but I didn't have to use it.
There are other factors to consider, such as color and material, but most Jura machines come with customizable aesthetics. We will cover more in-depth things to know in the next couple of sections, but for now, hold on to this list of general thoughts as we begin to browse the different Jura lines and examine what each different type of machine has to offer.
Maintenance and Cleaning: If you use steamed milk, I highly suggest changing the setting to display the "Rinse Milk System" prompt to appear right after using. The default is 10 minutes, and you cannot select this rinse from the Maintenance menu. The quicker you rinse out the milk residue, the less likely you are to get clogs. The manual also suggests to use the Jura Cappuccino Cleaner daily. I tend to rinse often and do a breakdown cleaning of the milk system and frother about every other day.
My wife LOVES coffee...I like coffee...she works ..I work...we have three kids...I would try to stay in bed longer than her to keep from having to make the coffee in the morning.. For Christmas I bought an Impressa F7 ..I was only prepared to spend about $1000 on a coffee machine at Williams-Sonoma...but the machine I could get for that really lacked some basic features...there were more expensive machines...but the F7 seemed to have most of what I wanted ...I got up Christmas morning to set up the machine, which was relatively easy...(although after 7 or 8 cups of "tweeking" the machine, my heart was pounding up in my throat and when the kids came down to see what Santa had left them I sent them back upstairs for making too much noise)...The coffee was REALLY good...it took a while to learn how to adjust the machine to get what we each liked, but now we love the machine...although there are occassional issues such as a luke warm cup now and then and the frother is marginal...it has made our life in the morning a very pleasant experience...it really doesn't require much upkeep ....wouldn't give it up now...
An espresso machine is a machine designed to brew coffee by forcing boiling water through fine coffee powder. An espresso coffee is usually taken with rich, creamy foam. Very often the espresso coffee is the base for many different types of coffee such as macchiato, café latte, café Americano, etc. Compared to all the different kinds of coffee, the espresso coffee has more caffeine as it is served in small quantities.
Turn, press, enjoy – that's how easy it is to enter the world of IMPRESSA C65 With the one-switch operating concept of the Rotary Switch and the 11-language plain text display, it's easy to create the perfect coffee every time. Thanks to the high-performance conical grinder, the beans are always freshly ground. The simple, compact design with its elegant combination of matte and gloss black gives the IMPRESSA C65 an imposing yet understated look in any surroundings.
Now we've looked at what the machine can do, let's turn our attention to what really matters, what real life customers think. We've had a good look around at reviews on the web, and collated the common themes. Hopefully this will give you a real feel for what is good and not so good about this machine, with some battle testing thrown into our Jura Impressa F8 review!
The Capresso EC100 offers you the chance to get creative and add variety to your coffee drinks, not only with espresso shots but also with lattes and cappuccinos using this espresso machine's two-part frother. This espresso maker comes with a frothing sleeve that lets you swirl hot steam and air into your milk to make a rich and foamy topping for your cappuccinos. You can remove the frothing sleeve and use the underlying steam tube that puts hot steam into milk, making it possible to make lattes.
The Jura A9 truly shines in the milk drinks department. It features 2 height adjustable spouts that go anywhere from two point two and up to five point four inches if you plan on using taller However, when it comes to the milk, the machine uses a pick-up tube system. What this means is that now you can just place the tube into the milk container and prepare delicious milk based drinks. For better results though, it's best that you either get Jura's cool control milk cooler or their optional thermal milk container. That's because not only is it better to keep milk chilled for sanitary reasons, but chilled milk also produces better froth.

subset: commoncrawl


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The Structure of Light Nuclei and its Effect on Precise Atomic Measurements
My talk will consist of three parts: (a) what every atomic physicist needs to know about the physics of light nuclei [and no more]; (b) what nuclear physicists can do for atomic physics; (c) what atomic physicists can do for nuclear physics. A brief qualitative overview of the nuclear force and calculation techniques for light nuclei will be presented, with an emphasis on debunking myths and on recent progress in the field. Nuclear quantities that affect precise atomic measurements will be discussed, together with their current theoretical and experimental status. Finally, a discussion of those atomic measurements that would be useful to nuclear physics will be presented.
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- Zambia
- Lusaka
- Human Resources
- Rebus Research Consultancy
Rebus Research Consultancy
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Company nameRebus Research Consultancy
Establishment year 2016
Employees 6-10
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11731, Off Gardenia Road, Avondale, Lusaka, Zambia
Rebus Research is a research consultancy firm based in Lusaka, Zambia. It is specialized in Social and Health research work. Our scope of work range from data collection, analysis and report writing to program monitoring and Evaluation (M&E). Rebus Research is an assemblage of highly specialized professionals with vast experience in the areas of Law, Education, Statistics, Project Management ,and Water and Sanitation Health.
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Hotels in Heeia
Search for Heeia Hotels
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Best Heeia Hotels
What's Heeia like?If you're looking to discover somewhere new, look no further than Heeia. Whether you're planning to stay for a night or for the week, the area around Heeia has accommodation to fit every need. Search for hotels in Heeia with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Heeia hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Heeia hotel deals are here with our lowest price guarantee.
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Below are the number of accommodation options by star rating in Heeia and the surrounding area:
- • 15 5-star accommodation from GBP 204 per night
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- • 238 3-star accommodation from GBP 88 per night
- • 11 2-star accommodation from GBP 24 per night
How to get to Heeia
Flights to Heeia
- • Honolulu, HI (HNL-Daniel K. Inouye Intl.), 9.7 mi (15.6 km) from central Heeia
- • Kapolei, HI (JRF-Kalaeloa), 18.6 mi (30 km) from central Heeia
Things to see and do in Heeia
Things to see near Heeia:
- • Kaneohe Bay (1.7 mi/2.8 km from the city centre)
- • Kailua Beach (5.8 mi/9.3 km from the city centre)
- • Lanikai Beach (6.6 mi/10.6 km from the city centre)
- • Honolulu Harbor (8.9 mi/14.4 km from the city centre)
- • University of Hawaii at Manoa (9 mi/14.5 km from the city centre)
Things to do near Heeia:
- • Hawaii Theater (8.8 mi/14.1 km from the city centre)
- • Bay View Golf Course (2 mi/3.3 km from the city centre)
- • Hoʻomaluhia Botanical Garden (2.2 mi/3.6 km from the city centre)
- • Friendship Garden (2.6 mi/4.2 km from the city centre)
- • Kaneohe Klipper Golf Course (3.9 mi/6.3 km from the city centre)
When is the best time to visit Heeia?
- • Hottest months: September, August, October, July (average 30°C)
- • Coldest months: January, February, March, December (average 20°C)
- • Rainiest months: November, December, March and January (average 155.25 inches of rainfall)


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Engine technology puts China in global topbracelets silicone custom flightCome To Alabama For A Festival In The Spring Detroit has the dubious distinction of being one of the biggest talent pools of musicians who are famous elsewhere. And while this is shame, it also gives fans the ability to see greats like The Muggs in favorite small venues and hometown bars across the area. Gaining notoriety in Europe as one of the fresh bands fronting Detroit"s new generation of Dodge muscle cars, Danny Methric, Tony DeNardo and Todd Glass keep a low-key lifestyle in their home city. If youre worried about forgetting your password to your user account to log on to computer, insert a formatted USB memory key and note the drive letter that XP assigns. Next, click Start, Control Panel and select User Accounts. Click the user account click Prevent a forgotten password option on the left. XP will help keep a copy of the password on the memory key(the password is coded as can not be seen by other people, when the USB key is lost). If you then type incorrect password when you next log on the computer, XP will offer to recover it using the memory key. The band has also toured states like New Jersey, New York and even toured with the South by Southwest (SXSW) film and festival wristbands in Austin, Texas. Of course, there are goals that have to do with physical measurements (weight, body fat percentage, size), and other goals that might have to do with your performance, like running a certain time or distance. Another type of goal might be to get yourself geared up for a future event or challenge, like a 10k run, or a full or 1/2 marathon, or a triathlon, or a "Tough Mudder" event wristbands, or a long distance cycling event, or a 3-day walk, and so on. You could even schedule a vacation where you"ll be active, like climbing, or surfing, or skiing, or white water rafting, or hiking. You get the point. Whether at the New England Country Music Festival, or at any of the other national festivals, people nationwide have shown an enduring love for the music. Year after year, voters at the Country Music Awards look back on the Festivals to highlight the best performances. Award winners are forged at their live performances at these festivals. Every year at these Award ceremonies fans of Country are reminded sport wristbands of why they love the live show. Don"t miss out on that feeling and be sure to attend at least one country music festival this year. Monitoring all communication events, monitor all voice and video calls, text messages, or data connections registered by the phone, press the ring looking button and select Log, and press to open the general log. For each communication event, you can see the sender or recipient name, phone number, name. These events are fun and exciting. I personally will be going to Delta Fair and Music Festival so that I can take my daughter to enjoy all of the rides and see all of the vendors, I am a sucker for good crafts and end up spending a bundle. On that note, I hope this will guide you in some ideas for the weekend. Labor Day signifies the end of summer and there is no need to let it go to waste.
Development of thrust vector control provides improved combat capability. Zhao Lei reports.
China has mastered a field of cutting-edge aviation technology that is currently dominated by the United States and Russia, which is expected to give the nation"s fighter jets better combat capability.
The technology, known as thrust vector control, involves a movable thrust nozzle that enables a fixed-wing plane to change the direction of its engine exhaust. This allows the pilot to raise the aircraft"s nose cone vertically while maintaining forward momentum so the plane effectively "sits" on its own tail in an aerodynamic stall caused by low speed and a high angle of attack.
The use of such technology extensively boosts the maneuverability of a fighter jet, providing advantages in aerial combat, especially during close-range dogfights.
The idea of thrust vectoring is not new to the global aviation industry, as it has been used for nearly 100 years; first as a control mechanism for airships, and later applied to the design of fixed-wing combat planes on a small, experimental scale in 1960s.festival bracelets cheap custom wristbands cool wristbands fabric bracelets hen fest wristbands


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Nuxe 48 Hour Moisturizing Cream (Crème Fraîche de beauté) Review
Hey beauties! Since the Nuxe 48 Hour Moisturizing Cream (Crème Fraîche® de beauté) made it into my 2018 Skincare Favourites I thought that I should get an actual review up of it before I finish my jar. I tried a lot of moisturizers in 2018 when I was sent a ton of them to test for the Elle Canada Grand Prix. The Nuxe 48 Hour…View Post


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Use Article Rewriter to rewrite or paraphrase articles, full-length essays, or to find different and better ways to express simple words, phrases, or sentences. Whether you wish to reproduce textual content for a website, business document, email, tweet, or term paper, article rewriter will do the trick. Facilitate essay writing, expand your blogs and enhance your website's online visibility with quality content now.
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Background Guides are now online! Click here to view them.
All Position Papers are due by 13th December 2018.
Dear Delegates and Faculty Advisors,
I am honoured to invite you to the eighth annual conference of TISB Model United Nations, held on December 15th through 17th, 2018. This year, more than 500 students will fill the shoes of geopolitical actors to forge consensus and spearhead the fostering of diplomacy at the international level.
This year, committees range from steadfast General Assemblies, such as the DISEC and the HRC, to more innovative additions, such as the 1787 Constitutional Convention. Model UN promises delegates a number of learnings, chief among which are an exhilarating experience and a broader worldview. We at TISBMUN are committed to fulfilling these promises.
TISBMUN provides its participants with an unrivalled understanding of contemporary challenges, but that is far from all it offers. I attended my first TISBMUN in 2015, and in the three years since, I have seen a spectrum of debate ranging from disarray to diplomacy. The entirety of this spectrum poses important lessons to the delegates of tomorrow. Model United Nations is about far more than verbose arguments and obscure articles. It is about perseverance, and using research as a supplement for creativity and critical thought.
Please do not hesitate to contact us with any queries or concerns you may have. TISBMUN has always remained an unparalleled experience for all those who attend, and in that sense this year will be no different.
I look forward to seeing you in December.
Parthav Shergill
The International School Bangalore Model United Nations
Dear Delegates,
I am extremely excited to welcome you to the eighth session of TISBMUN. This year, TISB MUN is focussed on fostering both spirited debate and creative problem-solving in order to create long-lasting substantive solutions to real global problems. In that sense, our mission goes beyond creating a MUN but rather creating future global leaders.
From large General Assemblies to smaller crisis committees we are blending classic committees with innovative ones in order to appeal to a wide range of interests. We are also excited to introduce our first ever junior committee which will be the SOCHUM. From DISEC to the JCC, we will ensure that you get your voice heard and your opinions expressed. After all, it is not until every delegate raises their placard can the intricacies of Modal UN truly be expressed.
Over the three days, I would like to encourage you to make eloquent and substantive speeches while using your diplomacy with tact in order to sway the wind in your favour. I would like to encourage you to research both your agenda and country's policies in depth while keeping an open mind to differing opinions.
MUN has truly changed my life and shaped who I am. It has made me a better speaker, a better listener and taught me how to calmly and diplomatically express my opinions while listening to those of others. In the increasingly tense global atmosphere we are in, it is important to promote change through diplomacy. We, therefore, call upon delegates to act in order to preserve peace for generations to come. This has been at the core of the United Nations since 1945 and is exactly what TISB MUN will embody. It is sure to be an unforgettable experience.
Best Wishes,
Anusha Sarathy
The International School Bangalore Model United Nations
Greetings Delegates!
My name is Ananth Subramanya and it is my utmost honor to be serving as the Under-Secretary-General at this year's edition of TISBMUN.
Having attended over 20 Model UN conferences, I have come to the conclusion that a Model UN can be an intellectually stimulating and memorable experience if approached correctly. A Model UN should be approached as a learning avenue rather than an avenue to deliver memorized points and speeches. Delegates that attend TISBMUN 2018 should attend with through research, but also an open mind on policies. Great policies aren't made by quoting charters and pointing out flaws in other speeches but is made through a dialogue of diplomacy. My advice to all delegates attending TISBMUN 2018 is to step out of their comfort zone, be flexible, and be confident.
If you have any queries, please feel free to reach out to me. Looking forward to meeting you all this December!
Ananth Subramanya
Under-Secretary General
The International School Bangalore Model United Nations
Dear Delegates,
Welcome to TISB MUN 2018! TISB MUN was one of my first MUN experiences, and it taught me a lot of important things, like how to voice out my opinion, how to research, and most important of all, how to learn important social skills, while having fun and meeting new people from schools all around India.
Honestly, I was very amazed when I saw a whole new side of the people I had spoken to before, but it's true! MUN does bring out a whole new person inside you. It opens your mind to diverse views and opinions, while you learn about how things function in the real world and how difficult it is to come to a consensus when you are in a room with a lot of diverse people. The whole package experience is life-changing.
I hope you all have a great time here, and that this MUN helps you grow as a person and connect with more people!
Shrishti Ramaiah
Head of Logistics
The International School Bangalore Model United Nations
Dear future model United Nations delegates,
I am sure you are excited about embarking upon this unique journey that will take you through the world of Model United Nations. Trust me when I say that there is absolutely nothing like it. Nothing that tests such a wide multiplicity of skills and talents. To be successful in this convoluted world is not easy, but it ultimately all boils down to being determined. Nobody is born with a gavel in their hand. Ultimately, being able to succeed is something that can be taught by the greatest teacher to ever exist: experience.
But it is always great to get a head start. The world of MUN that you witness and experience is no doubt going to be different from those who came before, and those who came after you. Experiencing it for yourself will no doubt be indispensable, no matter how many lectures you hear about it. But listening to the experiences and of those who have already explored this world and embarked on this journey will nevertheless be of great value. This is the aim of this letter. To give you some basic tricks of the trade before you start playing the game yourself.
The tips are divided into 2 categories. 'Research' and 'In Committee'.
Many people choose to believe that relying on the internet for some basic facts and figures is sufficient to help you excel in committee. But research is much more than that. Obtaining data, facts and figures about the issue is integral to frame concrete arguments, but relying only on data about selective aspects of the agenda is not enough. This will simply give you a one-dimensional understanding of the topic, no matter how many websites you visit. Go into committee with just basic numbers on the main areas of the topic, and you will soon find that you are not able to keep up with the debate in committee. There will be a scarce number of areas where you will actually be able to argue. Therefore, to avoid this, you need to delve much deeper into the research aspect of the MUN. For example, if your agenda is about a particular war that took place in the past, talk to a relative or someone who lived during that period. Understand exactly what it was like living during that time. What were the issues. What were the problems. Read a book about the issue that will be debated in committee. I cannot express how much more a book gives you compared to reading a couple of articles or watching a documentary on the topic. There's absolutely no comparison. Once again I reiterate, having facts and figures to form opinions, back up arguments and speak intelligently and convincingly in committee is crucial, actually having a conversation with someone who had experienced the problem will go a long way to helping you understand the topic at a much deeper level.
Try to understand similar cases in the past or in the same period in different locations to the agenda being discussed and use them as case studies in order to try and understand how to attack the problem at hand. For example, if the agenda is related to the growth of drug cartels in Africa, fuelled by economic compulsion, one could use the drug trade in the Americas as a case study. In order to understand how to approach the problem, try and research on, for example, how the USA is dealing with these existing cartels in South Americas, how they try and restrict the influence of the existing cartels, the drug trade routes etc. and try and understand how that can be applied in the African context.
A basic fact that has been drilled into almost every new delegate from almost the minute he/she arrives is to never quote Wikipedia as a source of facts and figures. The larger point that is being made when someone tells you this is that credibility of the sources of your information is crucial. No matter how inflammatory, brilliant or sensational your claims may be, if you are not able to back it up with a credible source, they are next to meaningless in committee, because the lack of validity of the source will be the first thing other delegates will point out in this situation.
Identify websites that are essentially devoted to statistics and research. For example, if you are trying to learn more about your own country, the CIA World Factbook is a great place to start. It contains plentiful information on almost every major aspect of your country, from basic facts like the type of government and population, to more complicated issues like the current major political and environmental issues of the country.
Many delegates make the mistake of researching only on the topic at hand, and forgetting to give importance to research about one's own country. Never forget that at the end of the day, while you are trying to solve a global problem, special precedence must be given to how the issue relates to and affects your country. Protecting your country's interests and representing its beliefs are at the end of the day your main job. It does not matter whether you personally agree or disagree with your country's government's beliefs. You are essentially agreeing to play a character when you choose a country, and along with it come its beliefs and interests, which you must uphold at all times.
Finally, an important point to note is that there is no substitute to research. Having great soft skills and being able to work with people is important, but without doing your homework, there is not much that they will count for in committee.
In Committee:
Doing research is like watching game film. But walking into committee is when the real game begins. A common mistake that I have seen delegates make is trying to dominate and control proceedings right from the word go. Making a strong first impression on the chair is important, but there are two reasons this may go wrong. Firstly, acting dominant and controlling right from the first minute may make you come across as someone who is annoying to the other delegates or rather trying too hard. Secondly, even if it does work, other delegates will immediately see you as a threat to the gavel and try to shut you out of everything. Neither of these is doing you any favours in the long run.
Ideally, by the end of day 1, you want to establish yourself as one of the top 8-10 delegates, but not take control immediately. Get to know your fellow delegates and start working with them.
By about midway of the second day is a good time to have brought together a loyal group of delegates, which will form your core team going forward.
The person who does the best in committee is often midway between the most intelligent and the most likable person in committee. Being intelligent and having good arguments is not enough. Respecting people and being able to gather support and respect is what will make it count. But on the flip side, just being plain likeable is not enough. You may make plenty of friends in the process, but being taken seriously when it counts is just as important. Just joke around with other delegates the entire time, and be assured that the gavel will be a long way away.
Make sure that while drafting a resolution, even the most quiet members of your bloc on the fringe are able to get at least one or two ideas on the resolution. This will ensure that they feel some ownership on the resolution themselves and will drastically reduce their chances of switching to a different bloc.
While defending a resolution in front of committee, it is crucial that you are thorough with not just your points, but the points given by others as well. That ensures that any point that is brought up for clarification will enable to you speak up and defend it. Essentially, it gives you full ownership of your points and partial ownership of others' points. Even if one of your fellow sponsors has explained or defended on of the points on the resolution, add a point of your own. This truly goes a long way.
Finally, it is usually by the second half of day 2 or day 3 that tight blocs form, and there is little scope for a change in loyalties. This is when you go all out. Upto this point you should have been part of the spotlight, but this is the time, more than ever, to go out and dominate. Hold nothing back.
Once again, like I said, reading a hundred tips and tricks like these is nothing compared to going and experiencing the world of MUN for yourself. But, these will no doubt provide you with some insight and basic knowledge before you go out and embark on this incredible journey yourselves. There is truly no exercise available today that better tests so many different skills in such a short span of time like Model United Nations. The awards are important, but at the end of the day, the true beauty of doing MUN is in the skills you develop and hone in the process. The ability to argue intelligently. The ability to work with others. The ability to work with clarity, The ability to treat people with respect. The ability to earn respect for yourself. I have never seen anything like it. Model United Nations is no doubt one of the single most productive and helpful activities you can participate in. Not only do you have the opportunity to learn an immense amount, it equips you with skills that stay with you for life. I wish to sign off by wishing you all luck for this incredible journey of MUN waiting in store for you. Each one of you will have a different story to tell at the end of it. Good luck and enjoy yourselves!
Anurag Aditya Sharma
TISB Alumni Batch of 2016-17
IB 45 Scorer and TISB Topper
The Model United Nations Club is one of the most active clubs at TISB. We have been conducting MUN Conferences as a part of our school fest VIVUM till 2011. However, our students realized that an MUN Conference should be bigger and run separately from VIVUM. TISBMUN is completely organized by the students. Our students have successfully organized six MUN Conferences. Our best students have also served as Chairs and Assistant Directors at local conferences as well as Harvard MUN India, Ivy League MUN Conference India among other top international Conferences. We hope to make the seventh TISBMUN Conference a truly delighting one for you. Please feel free to email me anything regarding TISBMUN 2018.
Mr. Anand Jerome
French Faculty and In-charge of MUN


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SCYNEXIS Inc (NASDAQ:SCYX) was the target of a large growth in short interest in the month of January. As of January 31st, there was short interest totalling 1,579,870 shares, a growth of 27.7% from the January 15th total of 1,237,188 shares. Based on an average daily trading volume, of 3,201,647 shares, the days-to-cover ratio is currently 0.5 days. Approximately 3.5% of the shares of the stock are short sold.
A number of hedge funds have recently added to or reduced their stakes in SCYX. BlackRock Inc. increased its holdings in SCYNEXIS by 61.5% during the 2nd quarter. BlackRock Inc. now owns 180,751 shares of the company's stock valued at $296,000 after purchasing an additional 68,830 shares in the last quarter. Renaissance Technologies LLC acquired a new stake in SCYNEXIS during the 2nd quarter valued at $190,000. Northern Trust Corp increased its stake in shares of SCYNEXIS by 132.7% in the 2nd quarter. Northern Trust Corp now owns 116,079 shares of the company's stock valued at $190,000 after buying an additional 66,193 shares during the period. Private Advisor Group LLC acquired a new stake in shares of SCYNEXIS in the 3rd quarter valued at $240,000. Finally, Stonepine Capital Management LLC acquired a new stake in shares of SCYNEXIS in the 3rd quarter valued at $539,000. 41.53% of the stock is owned by hedge funds and other institutional investors.
Several equities analysts recently commented on the company. Zacks Investment Research downgraded SCYNEXIS from a "buy" rating to a "hold" rating in a research report on Friday, February 8th. Brookline Capital Management restated a "buy" rating on shares of SCYNEXIS in a research report on Friday, January 4th. ValuEngine downgraded SCYNEXIS from a "buy" rating to a "hold" rating in a research report on Tuesday, December 25th. Finally, Maxim Group set a $4.00 target price on SCYNEXIS and gave the stock a "buy" rating in a research report on Tuesday, November 13th. Two research analysts have rated the stock with a hold rating and eight have issued a buy rating to the company's stock. SCYNEXIS currently has an average rating of "Buy" and an average price target of $4.78.
SCYX stock opened at $1.39 on Thursday. SCYNEXIS has a fifty-two week low of $0.35 and a fifty-two week high of $2.15. The firm has a market cap of $63.80 million, a P/E ratio of -1.38 and a beta of 2.28. The company has a quick ratio of 4.53, a current ratio of 4.53 and a debt-to-equity ratio of 0.27.
SCYNEXIS (NASDAQ:SCYX) last released its quarterly earnings results on Tuesday, November 13th. The company reported $0.01 earnings per share for the quarter, beating the Zacks' consensus estimate of ($0.17) by $0.18. SCYNEXIS had a negative return on equity of 102.52% and a negative net margin of 8,592.97%. The firm had revenue of $0.06 million during the quarter, compared to analysts' expectations of $0.06 million. As a group, equities research analysts expect that SCYNEXIS will post -0.51 EPS for the current fiscal year.
COPYRIGHT VIOLATION WARNING: "SCYNEXIS Inc (SCYX) Sees Large Growth in Short Interest" was originally posted by Modern Readers and is the sole property of of Modern Readers. If you are accessing this story on another publication, it was illegally copied and republished in violation of U.S. & international trademark and copyright legislation. The correct version of this story can be viewed at https://www.modernreaders.com/news/2019/02/14/scynexis-inc-scyx-sees-large-growth-in-short-interest.html.
About SCYNEXIS
SCYNEXIS, Inc, a drug development company, develops and commercializes anti-infectives to address unmet therapeutic needs. It is developing its lead product candidate, SCY-078, as a novel oral and intravenous drug for the treatment of various fungal infections, including serious and life-threatening invasive fungal infections.
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Podcast: Download (Duration: 12:20 — 12.4MB)
The Twenty-Sixth Sunday after Pentecost: November 11, 2018
Ruth 3:1-5; 4:13-17 | Psalm 127
Hebrews 9:24-28 | Mark 12:38-44
Preacher: The Rev. Leigh Mackintosh, Associate Rector of St. Michael's Church
On the surface, Jesus' talk of tithing in the temple seems like an intentional nudge by our stewardship committee to turn in your pledge (if you didn't already!).
But I think there's more to this gospel teaching than money. Jesus calls his disciples to go deeper – to look beneath the surface of things. (more…)


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Erda, Sharma eliminated from W Series qualifiers
Mira Erda and Sneha Sharma have missed out on an entry into the W Series, an all-female racing champion that ditches the conventional pay-to-drive model prevalent in the junior racing ladder.
Both Erda and Sharma were included in the W Series' preliminary list of 55 candidates, who were shortlisted from "more than 100 applicants from 30 countries around the world."
All selected candidates, including Erda and Sharma, were invited to Austria for a three-day evaluation process, where they were judged by a panel led by former Formula 1 driver David Coulthard, Le Mans 24 Hours winner Alex Wurz and ex-IndyCar racer Lyn St. James.
Points were awarded to candidates on the basis of 10 modules, including a test of their driving ability at the Wachauring circuit using Ford Fiesta ST and Porsche Cayman S road cars.
After the scores were tallied, 28 drivers were selected for further assessment ahead of the W Series' inaugural season.
Unfortunately neither Erda nor Sharma, both of whom are seasoned racers in the JK Tyre National Racing Championship, were included in the list.
Series boss Catherine Bond Muir said that she was "massively impressed" by all 54 drivers present and that it was tough to shortlist 28 candidates from them.
Muir also revealed that drivers who didn't make it to the next stage are allowed to enter again in 2020.
"All W Series' qualifier-drivers here at the Wachauring [Melk, Austria] are superstars, every single one of them," Muir said.
"But the sad fact is that not all of them will continue to the next stage of our driver selection programme. That's competition. That's sport. That's racing.
"So to all of them who've made it through to the next stage, I say: congratulations and good luck in Almeria [Spain] in March, the final stage of our driver selection programme.
"And to those of them who haven't made it through to the next stage, I say: obviously, today is a sad day.
"But one thing I've seen over the past three days, and that I've been massively impressed by, is that each and every one of our qualifier-drivers is tough, brave and strong.
"And of course we'll therefore encourage them to work hard on their driving for the next few months and then consider re-applying for the 2020 W Series season when the time comes."
Previous article
W Series names 28 drivers for final stage of selection
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W Series hopeful confused by judging process
About this article
|W Series
|Mira Erda , Sneha Sharma
|Rachit Thukral


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As with all Greek traditions, the custom varies from region to region, but one thing is for certain: "podariko" is practiced almost everywhere on New Year's and it symbolizes "entering with the good foot," or in most cases, the right foot.
For the family occupying the house, "podariko" represents a means of ushering in the new year with good luck.
In some parts of Greece, the youngest child is the first to enter after the turning of the new year — always with the right foot.
In many regions, the child carries the family icon, or the icon the family has designated as their patron saint.
On several Greek islands, locals perform a "podariko jig," which entails taking one step with the right foot, saying "Μέσα καλό!" (enter good!) and then taking two steps back and saying "Κι έξω κακό!" (and evil out!).
To ensure that bad luck and evil exit the house, each family does the ritual three times. After the third entrance, someone smashes a pomegranate and all family members dip their fingers into a honey jar and lick the honey so that life in the house will remain sweet throughout the year.
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By Karen DePauw,Susan Gavron
Important detect: The electronic version of this publication is lacking a few of the photographs present in the actual edition.
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What's on the ballot?
Connecting to MARTA is the only item on the ballot and voters will be asked to vote yes or no to this question: "Gwinnett County has executed a contract for the provision of transit services, dated as of August 2, 2018. Shall this contract be approved?"
Voting "yes" is a vote to create a new one-penny sales tax to expand MARTA in Gwinnett based on Gwinnett's plan for transit expansion and its contract with MARTA. The contract includes provisions such as providing control to Gwinnett over funds and spending, requiring funds to be spent to benefit Gwinnett, solidifying Gwinnett's transit plan, and providing Gwinnett with three seats on the MARTA board.
Voting "no" would prevent expansion of transit options.


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As blood levels of testosterone increase, this feeds back to suppress the production of gonadotrophin-releasing hormone from the hypothalamus which, in turn, suppresses production of luteinising hormone by the pituitary gland. Levels of testosterone begin to fall as a result, so negative feedback decreases and the hypothalamus resumes secretion of gonadotrophin-releasing hormone.
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This post can absolutely change your life, and probably help you avoid some pitfalls. Like shrunken balls. (I am not an expert in the synthetic anabolic testosterone drugs used by bodybuilders — they carry lots of risks but pack a big punch if you want to get swole. Bulletproof is all about having massive clean energy, looking good, and living a very long time…so anabolic steroids aren't on my roadmap.)
When many people think of someone with a high level of testosterone, they may picture a man loaded with strength, sexual prowess, and machismo. But while high-T has been correlated with all those things, it's also been correlated with aggression, sexual misconduct, and violence. One of testosterone's most common uses—as a performance-enhancing steroid—illustrates both sides of the hormone. Injecting steroids can be a quick way for athletes to dramatically improve performance, but the side effects can also be extreme, and can include excessive body hair growth, sexual dysfunction, and the hard-to-corral anger known as "roid rage."
Transdermal preparations of testosterone utilize the fact that the skin readily absorbs steroid hormones. Initial transdermal preparations took the form of scrotal patches with testosterone loaded on to a membranous patch. Absorption from the scrotal skin was particularly good and physiological levels of testosterone with diurnal variation were reliably attained. The scrotal patches are now rarely used because they require regular shaving or clipping of scrotal hair and because they produce rather high levels of dihydrotestosterone compared to testosterone (Behre et al 1999). Subsequently, non-scrotal patches were developed but the absorptive capacity of non-scrotal skin is much lower, so these patches contain additional chemicals which enhance absorption. The non-scrotal skin patches produce physiological testosterone levels without supraphysiological dihydrotestosterone levels. Unfortunately, the patches produce a high rate of local skin reactions often leading to discontinuation (Parker and Armitage 1999). In the last few years, transdermal testosterone gel preparations have become available. These require daily application by patients and produce steady state physiological testosterone levels within a few days in most patients (Swerdloff et al 2000; Steidle et al 2003). The advantages compared with testosterone patches include invisibility, reduced skin irritation and the ability to adjust dosage, but concerns about transfer to women and children on close skin contact necessitate showering after application or coverage with clothes.
During the second trimester, androgen level is associated with sex formation.[13] This period affects the femininization or masculinization of the fetus and can be a better predictor of feminine or masculine behaviours such as sex typed behaviour than an adult's own levels. A mother's testosterone level during pregnancy is correlated with her daughter's sex-typical behavior as an adult, and the correlation is even stronger than with the daughter's own adult testosterone level.[14]
It may also become a treatment for anemia, bone density and strength problems. In a 2017 study published in the journal of the American Medical Association (JAMA), testosterone treatments corrected anemia in older men with low testosterone levels better than a placebo. Another 2017 study published in JAMA found that older men with low testosterone had increased bone strength and density after treatment when compared with a placebo.
Alprostadil (also known as prostaglandin E1 [PGE1]) is the prominent known smooth-muscle dilator of the corpus cavernosum. Its mechanism of action is believed to be the promotion of intracellular accumulation of cyclic adenosine monophosphate, thereby causing decreased intracellular accumulation of calcium and resulting smooth muscle relaxation. Alprostadil can be delivered to the erectile tissue either via an intraurethral suppository that is massaged and then absorbed across the corpus spongiosum of the urethra to the corpora cavernosa, or directly injected into the corpora cavernosa. When administered urethrally, doses are substantially higher than when directly injected (typical dosing is 500 mcg to 1 mg intraurethral compared with 2.5 mcg to 20 mcg intracavernosal).
Knowing about your history of ED will help your health provider learn if your problems are because of your desire for sex, erection function, ejaculation, or orgasm (climax). Some of these questions may seem private or even embarrassing. However, be assured that your doctor is a professional and your honest answers will help find the cause and best treatment for you.
So here's something that's really fascinating. Healthy eating is a way to reduce anxiety and stress. Now how, you may be asking, right? Well, think about it. We live in a world where there are so many variables and where we don't have control over our lives. But now, with healthy eating, we have control over what goes into our body. And now having that control empowers us to be even healthier, to be more directive in what we do. And certainly, that begins then to reduce the anxiety and the stress. So all in one, you have a healthier body, but certainly a healthier mind.
Sexual stimulation causes the release of neurotransmitters from cavernosal nerve endings and relaxation factors from endothelial cells lining the sinusoids. NOS produces NO from L-arginine, and this, in turn, produces other muscle-relaxing chemicals, such as cGMP and cyclic adenosine monophosphate (cAMP), which work via calcium channel and protein kinase mechanisms (see the image below). This results in the relaxation of smooth muscle in the arteries and arterioles that supply the erectile tissue, producing a dramatic increase in penile blood flow.
^ Jump up to: a b Lazaridis I, Charalampopoulos I, Alexaki VI, Avlonitis N, Pediaditakis I, Efstathopoulos P, Calogeropoulou T, Castanas E, Gravanis A (2011). "Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis". PLoS Biol. 9 (4): e1001051. doi:10.1371/journal.pbio.1001051. PMC 3082517. PMID 21541365.
Even before the study yields its findings, Dr. Swerdloff said a few important points should be emphasized. "I want to make it clear that this is not a made-up disease," he said. "It is well known in younger men that if you have a failure to produce normal testosterone, there are certain signs and symptoms that create a kind of syndrome. Treatment for low testosterone has been documented to be beneficial."
A larger national study, the National Health and Social Life Survey, looked at sexual function in men and women.4 This study surveyed 1,410 men aged 18 to 59 and also documented an increase in ED with age. Additionally, the study found a decrease in sexual desire with increasing age. Men in the oldest cohort (50 to 59) were more than 3 times as likely to experience erection problems and to report low sexual desire compared with men 18 to 29. Experience of sexual dysfunction was more likely among men in poor physical and emotional health. The study also concluded that sexual dysfunction is an important public health concern and that emotional issues are likely to contribute to the experience sexual dysfunction.
"Bring back the younger inner you," says the Low T Center. According to its website, its president, Mr. (notably not "Dr.") Mike Sisk, "created these centers out of a need." They promise their testosterone injections "do not just help boost a low sex drive but can also boost energy, decrease body fat, irritability, and depression." They go so far as to claim that "research finds testosterone replacement can solve long-term health issues like Alzheimer's and heart disease."
Testosterone replacement therapy may improve energy, mood, and bone density, increase muscle mass and weight, and heighten sexual interest in older men who may have deficient levels of testosterone. Testosterone supplementation is not recommended for men who have normal testosterone levels for their age group due to the risk of prostate enlargement and other side effects. Testosterone replacement therapy is available as a cream or gel, topical solution, skin patch, injectable form and pellet form placed under the skin.
A related issue is the potential use of testosterone as a coronary vasodilator and anti-anginal agent. Testosterone has been shown to act as a vasodilator of coronary arteries at physiological concentrations during angiography (Webb, McNeill et al 1999). Furthermore men given a testosterone injection prior to exercise testing showed improved performance, as assessed by ST changes compared to placebo (Rosano et al 1999; Webb, Adamson et al 1999). Administration of one to three months of testosterone treatment has also been shown to improve symptoms of angina and exercise test performance (Wu and Weng 1993; English et al 2000; Malkin, Pugh, Morris et al 2004). Longer term studies are underway. It is thought that testosterone improves angina due its vasodilatory action, which occurs independently of the androgen receptor, via blockade of L-type calcium channels at the cell membrane of the vascular smooth muscle in an action similar to the dihydropyridine calcium-channel blockers such as nifedipine (Hall et al 2006).
medicines called alpha-blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of Sildenafil with alpha-blockers can lead to a drop in blood pressure or to fainting
The prevalence of biochemical testosterone deficiency increases with age. This is partly due to decreasing testosterone levels associated with illness or debility but there is also convincing epidemiological data to show that serum free and total testosterone levels also fall with normal aging (Harman et al 2001; Feldman et al 2002). The symptoms of aging include tiredness, lack of energy, reduced strength, frailty, loss of libido, decreased sexual performance depression and mood change. Men with hypogonadism experience similar symptoms. This raises the question of whether some symptoms of aging could be due to relative androgen deficiency. On the other hand, similarities between normal aging and the symptoms of mild androgen deficiency make the clinical diagnosis of hypogonadism in aging men more challenging.
Studies show that high cholesterol and obesity are linked to erectile dysfunction, and both can be improved through diet. "A heart-healthy diet that prevents cardiovascular disease and maintains a healthy weight is also good for erectile functioning," says Feloney. An ideal diet plan involves eating foods low in saturated fat and cholesterol and having frequent servings of fruits, vegetables, and plenty of whole grains.
A recent study compared total and bioavailable testosterone levels with inflammatory cytokines in men aged 65 and over. There was an inverse correlation with the pro-inflammatory soluble interleukin-6 receptor, but no association with interleukin-6 (IL-6), highly sensitive CRP (hsCRP), tumor necrosis factor-α (TNF-α) or interleukin-1β (IL-1β (Maggio et al 2006). Another trial found that young men with idiopathic hypogonadotrophic hypogonadism had higher levels of proinflammatory factors interleukin-2 (IL-2), interleukin-4 (IL-4), complement C3c and total immunoglobulin in comparison to controls (Yesilova et al 2000). Testosterone treatment in a group of hypogonadal men, mostly with known coronary artery disease, induced anti-inflammatory changes in the cytokine profile of reduced IL-1β and TNF-α and increased IL-10 (Malkin, Pugh, Jones et al 2004).
If you have symptoms of ED, it's important to check with your doctor before trying any treatments on your own. This is because ED can be a sign of other health problems. For instance, heart disease or high cholesterol could cause ED symptoms. With a diagnosis, your doctor could recommend a number of steps that would likely improve both your heart health and your ED. These steps include lowering your cholesterol, reducing your weight, or taking medications to unclog your blood vessels.
Of the drugs used for depression, tricyclic antidepressants may be associated with erectile problems and other drugs may be substituted to prevent this complication. Currently available substitutes include bupropion, nefazodone, and trazodone. The selective serotonin reuptake inhibitors (eg, fluoxetine, sertraline, paroxetine, citalopram) can also cause difficulties with ED, but they might also have other significant sexual side effects, including decreased libido and anorgasmia.
These are not currently approved by the FDA for ED management, but they may be offered through research studies (clinical trials). Patients who are interested should discuss the risks and benefits (informed consent) of each, as well as costs before starting any clinical trials. Most therapies not approved by the FDA are not covered by government or private insurance benefits.
Men who watch a sexually explicit movie have an average increase of 35% in testosterone, peaking at 60–90 minutes after the end of the film, but no increase is seen in men who watch sexually neutral films.[43] Men who watch sexually explicit films also report increased motivation, competitiveness, and decreased exhaustion.[44] A link has also been found between relaxation following sexual arousal and testosterone levels.[45]
And surgery comes with its own serious risks, such as developing incontinence or impotence, while radiation can result in urinary problems. — Peter Loftus, WSJ, "Surgery Adds Three Years to Lives of Prostate-Cancer Patients, Study Finds," 12 Dec. 2018 Male-impotence pill Viagra began facing generic competition late last year, while the Lyrica pain treatment is expected to confront generics at the end of this year. — Jonathan D. Rockoff, WSJ, "Pfizer Narrows Guidance on Tougher Pricing, Generic Competition," 30 Oct. 2018 Arkham Horror Third Edition is a classic struggle of agency versus impotence, set in the uncanny world of H.P. Lovecraft's Cthulhu mythos. — Charlie Theel, Ars Technica, "Arkham Horror Third Edition: The classic Lovecraft adventure returns," 24 Nov. 2018 There's obviously a lot of anger and frustration here toward the US government at the moment—along with side effects like bottled rage and sometimes a creeping sense of ineptitude or impotence about our ability to do anything about it. — Corey Seymour, Vogue, "Pussy Riot's Nadya Tolokonnikova On Her New Guide To Activism, Raising The Next President Of Russia, And Her "Holy War" On Fairy Tales," 12 Oct. 2018 In exchange for political impotence, they would be mostly left alone and allowed to get rich. — Paul Mozur, New York Times, "Inside China's Dystopian Dreams: A.I., Shame and Lots of Cameras," 8 July 2018 Their suspicion is compounded by rumors that the polio vaccine causes impotence, death and, ironically, paralysis. — Meher Ahmad, New York Times, "Pakistan Has Just One New Polio Case, but Isn't Declaring Victory Yet," 20 May 2018 Fighting back, even as an exercise in impotence, did a lot for McCain. — Alex Horton, Washington Post, "John McCain rebelled at the Naval Academy — and as a POW — long before he was a Senate maverick," 3 May 2018 Feelings of desperation and impotence are being felt throughout Central America, where the lawlessness, endemic poverty and levels of gang violence akin to war zones that have driven so many families from their homes show little signs of abating. — Washington Post, "Violence keeps Central Americans coming to US despite Trump," 21 June 2018
In rare cases, the drug Viagra ® can cause blue-green shading to vision that lasts for a short time. In rare cases, the drug Cialis® can cause or increase back pain or aching muscles in the back. In most cases, the side effects are linked to PDE5 inhibitor effects on other tissues in the body, meaning they are working to increase blood flow to your penis and at the same time impacting other vascular tissues in your body. These are not 'allergic reactions'.
Over a 2-year period, a third of the men randomized to a weight loss program demonstrated resolution of erectile dysfunction.10 A Mediterranean diet and nutritional counseling reported increased erectile quality.18 Little evidence supports that increased physical activity alone improves erectile quality; however, the strong association between physical activity and lower BMI is well described, and therefore recommended for men with erectile dysfunction and without a contraindication to physical activity.
Erectile dysfunction (ED) affects 50% of men older than 40 years, [4] exerting substantial effects on quality of life. [5] This common problem is complex and involves multiple pathways. Penile erections are produced by an integration of physiologic processes involving the central nervous, peripheral nervous, hormonal, and vascular systems. Any abnormality in these systems, whether from medication or disease, has a significant impact on the ability to develop and sustain an erection, ejaculate, and experience orgasm.
Commercials do mention other potential side-effects for the male user, calling them "rare," including swollen and painful breasts, blood clots in the legs, increased risk for prostate cancer, problems breathing during sleep (sleep apnea), change in the size and shape of the testicles, and a low sperm count. But you're not supposed to focus on the details. Instead, just think of the energy you'll have. The great sex you'll have. And the muscles. It will be a veritable second adolescence as your aging body bursts into new bloom.
In order to establish whether normal erections are occurring overnight (nocturnal erections), the doctor may organise nocturnal penile tumescence (NPT) testing. This involves wearing a monitor overnight in your own home. The data from this monitor is then assessed to analyse how often erections occurred, how long they lasted, and how rigid and large the penis was during the erections. If NPT testing is normal, the cause of erectile dysfunction is usually psychological. If not, further testing of the blood flow in the genital area may be required to see if there is blockage or leakage. The doctor may also organise a blood test of levels of hormones such as testosterone, prolactin and thyroid stimulating hormone to see if these are contributing to the erectile dysfunction.
The aim of treatment for hypogonadism is to normalize serum testosterone levels and abolish symptoms or pathological states that are due to low testosterone levels. The exact target testosterone level is a matter of debate, but current recommendations advocate levels in the mid-lower normal adult range (Nieschlag et al 2005). Truly physiological testosterone replacement would require replication of the diurnal rhythm of serum testosterone levels, but there is no current evidence that this is beneficial (Nieschlag et al 2005).
The diagnosis of late-onset hypogonadism requires the combination of low serum testosterone levels with symptoms of hypogonadism. Questionnaires are available which check for the symptoms of hypogonadism. These have been validated for the assessment of aging patients with hypogonadism (Morley et al 2000; Moore et al 2004) but have a low specificity. In view of the overlap in symptoms between hypogonadism, aging and other medical conditions it is wise to use a formal method of symptom assessment which can be used to monitor the effects of testosterone replacement.
This paper will aim to review the current evidence of clinical effects of testosterone treatment within an aging male population. As with any other clinical intervention a decision to treat patients with testosterone requires a balance of risk versus benefit. We shall try to facilitate this by examining the effects of testosterone on the various symptoms and organs involved.
Erectile dysfunction is known to be associated with general health status, thus, lifestyle modification improves erectile function and decreases the rate of decline of function with aging. One year after discontinuation of smoking, patients were found to have a 25% improvement in erectile quality.16 In addition, multivariate analysis found obesity is associated with erectile dysfunction with an approximately 50% increase in ED in obese men as compared with normal weight men.17
Testosterone is a sex hormone that plays important roles in the body. In men, it's thought to regulate sex drive (libido), bone mass, fat distribution, muscle mass and strength, and the production of red blood cells and sperm. A small amount of circulating testosterone is converted to estradiol, a form of estrogen. As men age, they often make less testosterone, and so they produce less estradiol as well. Thus, changes often attributed to testosterone deficiency might be partly or entirely due to the accompanying decline in estradiol.
THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.
The development of an erection is a complex event involving integration of psychologic, neurologic, endocrine, vascular, and local anatomic systems. Positron emission tomography scanning studies have suggested that sexual arousal is activated in higher cortical centers that then stimulate the medial preoptic and paraventricular nuclei of the hypothalamus.5 These signals ultimately descend through a complex neural network involving the parasympathetic nervous system and eventually activate parasympathetic nerves in the sacral area (S2 to S4).
Diabetes is an example of an endocrine disease that can cause a person to experience impotence. Diabetes affects the body's ability to utilize the hormone insulin. One of the side effects associated with chronic diabetes is nerve damage. This affects penis sensations. Other complications associated with diabetes are impaired blood flow and hormone levels. Both of these factors can contribute to impotence.
Additionally, the physiologic processes involving erections begin at the genetic level. Certain genes become activated at critical times to produce proteins vital to sustaining this pathway. Some researchers have focused on identifying particular genes that place men at risk for ED. At present, these studies are limited to animal models, and little success has been reported to date. [4] Nevertheless, this research has given rise to many new treatment targets and a better understanding of the entire process.