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Online reviews and family recommendations led me to Extreme's One Hour Heating & Air Conditioning services. I'm very grateful that they did! The technician, Michael T., was outstanding. He was friendly, very knowledgeable, and explained everything in a manner in which I could understand. He was super-prompt, he did only what truly needed done, and explained ways for me to better maintain my own AC unit. He also suggested I consider having my units serviced from time to time due to their age, but recommended I wait until there was a special going on. He also was very friendly with my incredibly hyper dog, who was very happy to jump all over him. To me, that all speaks to top-notch service. I know now that the only call I need to make if I'm having trouble with heating & air is to Extreme's One Hour Heating & Air Conditioning. Thanks again, Michael!
As your trusted HVAC service experts since 1960, Miller's Air Conditioning & Heating was established before Livermore became an official city. We have a long-term commitment to the local community and have built solid relationships across generations of families. Family owned and operated, we recognize the importance of an HVAC provider you can always depend on to serve your best interests. At Miller's Air Conditioning & Heating we uphold exacting standards of quality, from the products we recommend and install, to the integrity of workmanship. By refusing to settle, we provide a greater return from all of our services, including new system installation, replacement, seasonal maintenance, and repair of air conditioners, heat pumps, furnaces, ductless units, and attic fans. Whether you're a first-time homeowner or dissatisfied with the contractors you've tried in the past, we'll make sure Miller's Air Conditioning & Heating satisfies your every expectation.
Air conditioning makes deep plan buildings feasible, for otherwise they would have to be built narrower or with light wells so that inner spaces received sufficient outdoor air via natural ventilation. Air conditioning also allows buildings to be taller, since wind speed increases significantly with altitude making natural ventilation impractical for very tall buildings.[citation needed] Comfort applications are quite different for various building types and may be categorized as:
Air ducts come in two forms: cool air ducts (also known as "return ducts") and warm air ducts (also known as "supply ducts"). Warm air from the furnace enters the home through the warm air registers. No more than 20: of these warm air ducts and registers should ever be closed off – this hinders air flow and could result in the overheating of the heat exchanger, causing costly damage to you home heating system.
Some systems include an "economizer mode", which is sometimes called a "free-cooling mode". When economizing, the control system will open (fully or partially) the outside air damper and close (fully or partially) the return air damper. This will cause fresh, outside air to be supplied to the system. When the outside air is cooler than the demanded cool air, this will allow the demand to be met without using the mechanical supply of cooling (typically chilled water or a direct expansion "DX" unit), thus saving energy. The control system can compare the temperature of the outside air vs. return air, or it can compare the enthalpy of the air, as is frequently done in climates where humidity is more of an issue. In both cases, the outside air must be less energetic than the return air for the system to enter the economizer mode.


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57% of companies around the world said the deepest level at which they could track the effectiveness of social media marketing was in terms of engagement.
Awareness Of Big Data Among North American Retail Execs [CHART]
Only 17% of North American retail executives were unaware of the concept of Big Data.
Frequency Of Inbound Marketing Tool Use, 2012 [CHART]
SEO was the most time-consuming—and most used—inbound marketing tactic for online marketers worldwide: 23.9% spent more than half their time on SEO.
State Of Digital Marketing 2012 [INFOGRAPHIC]
This infographic from webmarketing 123 highlights relevant statistics for the state of both B2B and B2C digital marketing.
Top Inbound Marketing Activities For SEO [CHART]
76% of SEOs say they have spent time in the past year setting up and running a Facebook business page, making this the most common inbound marketing-focused action.
Metrics: Average vs. Top-Performing Facebook Brand Pages By Users [CHART]
For average Facebook brand pages, 83% of fans were considered Joiners who just participated in a campaign without spreading the word about it.
Big Data Analytics Familiarity [CHART]
42% of businesses are unfamiliar with big data analytics.
Embracing Online Culture [INFOGRAPHIC]
J6 Design designed this infographic that offers seven reasons you should embrace online culture.
Integration Of Web Analytics Into Overall Business Strategy [CHART]
14% of companies reported that they did not tie web analytics to their overall business strategy.
Usefulness Of Web Analytics [CHART]
A majority of marketers worldwide say that less than half of all the analytics data they collect is actually useful for decision-making.
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Apr 11, 2018. Whats search for dating site in usa behind the scenes at the sites and apps you know and love and. Find your single parent match. Meet thousands of single parents looking for love. Nov 4, 2015. Looking for Love: Top HIV Dating Sites.
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Mar 15, 2012. Ashley Madison, the website for people looking to have affairs, has the honor of being the largest niche dating site in the world, Biderman said. Positive Dating was featured in Entrepreneur, Miami Herald, USA Today, Chicago Sun-Times, and. Millions of guys like you, looking for friendships, dating and relationships. Newmeet.com - Free Dating site! You can meet men and women, singles. Weve tested all US dating sites, matchmaker and casual dating services for you.


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Sizing Europe proves he's still a champion on opening day at Punchestown
Veteran Sizing Europe landed his second Champion Chase to huge acclaim on the first day of the Festival at Punchestown.
The 12-year-old, also a dual Cheltenham Festival winner, was having his fifth run in the race, having won it in 2012.
Ridden by Andrew Lynch, he beat David Pipe's Ballynagour by over five lengths and emotional owner Alan Potts, who will now consider retiring his star, said: 'He was back to his brilliant best here.'
Winner: Andrew Lynch riding Sizing Europe after winning at Punchestown on Tuesday
Silverware: Andrew Lynch kisses the Blessington Cup after riding Sizing Europe to victory
Faugheen, winner of the Neptune Investment Hurdle at Cheltenham, had his 2015 Champion Hurdle odds slashed to 5-1 after making all in the Grade One novices' hurdle.
It was his fifth straight win and rider Ruby Walsh said: 'Those were good novices behind.
'He's beaten them 12 lengths and it could've been 25.'
Front runner: Sizing Europe clears the last to win at Punchestown
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Pay per click (PPC) advertising, commonly referred to as Search Engine Marketing, delivers targeted traffic and conversions and will yield results faster than organic search engine optimization. Successful PPC marketing programs offer incredible revenue and brand-building opportunities. However, without a thorough understanding of how PPC works, it is very easy to mismanage valuable advertising budgets. That's where we come in!
Another ethical controversy associated with search marketing has been the issue of trademark infringement. The debate as to whether third parties should have the right to bid on their competitors' brand names has been underway for years. In 2009 Google changed their policy, which formerly prohibited these tactics, allowing 3rd parties to bid on branded terms as long as their landing page in fact provides information on the trademarked term.[27] Though the policy has been changed this continues to be a source of heated debate.[28]
There are endless platforms for video marketing. YouTube, broadcast television, video boards and street marketing, you name it. The possibilities are endless. With a smartphone, consumers can access online video anytime, anywhere. The same is not true with traditional, paper marketing. With video, you can reach your audience wherever they are in a cost-effective way.
This is any form of content which was paid for, usually by a company promoting another company or brand. It is written in the style of the site publishing it, much like native advertising, but isn't actually an ad — it's a valuable piece of written or visual content meant to inform the viewer. Usually, sponsored posts get organically shared via social networks, too, so they get an extra push when it comes to distribution.
Don't neglect your website when it comes to publishing your video. Use it on any page that's relevant. If you've got a product video, for instance, you'll want to embed the video on your homepage, as well as your product or ecommerce pages. If you publish a blog post about your product, include the video! If you've got an FAQ page with questions about your product, include the video there, too!
Videos are highly shared across the web, and marketers who include rich descriptions and keywords in video titles can also benefit from video platform search visibility and a presence on the video results section of Google. Additionally, adding text transcripts of video content posted on a website can improve the SEO value it has for the site. Pairing video with written content, whether an article or well-written metadata, has proven to be a strong SEO strategy for businesses, with video listings appearing in the top 100 listings for more than 70 percent of searches, according to Marketingweek.
The inbound methodology is the marketing and sales approach focused on attracting customers through content and interactions that are relevant and helpful. Each video you create should acknowledge your audience's challenges and provide a solution. Looking at the big picture, this content guides consumers through the journey of becoming aware of, evaluating, and purchasing your product or service.
In addition to the entertainment aspect, more and more marketers are focusing on video marketing strategies because of how beneficial they are. Think about it from your own perspective for a minute. Would you rather read a long page full of text or watch a quick video to learn about a new product? Would you rather spend time reading about the steps of a company's sales process or watch an animation to associate each step with a visual aid? If you're like 80 percent of the population, you'd rather watch the video.
Why It Worked So Well: For this client video, we used a combination of b-roll footage and a handful of client testimonials. By using more than one person, the message we're trying to get across is continually reinforced through many different voices. The testimonials provide evidence that our client does solve customer's problems, while the images show how it's done. This combination works brilliantly because the video captures the benefits of working with our client with very little sales speak.
In the beginning, it was rough for Sharpe. No one out there should think that it's going to be easy whatsoever. His journey took years and years to go from an absolute beginner, to a fluid and seasoned professional, able to clearly visualize and achieve his dreams, conveying his vast knowledge expertly to those hungry-minded individuals out there looking to learn how to generate a respectable income online.
We encourage you to adopt this results-first frame of mind. Keeping an eye on the metrics that actually help you accomplish your video goals is more important than anything, so don't be blinded by the glint of a high impression count — or at least not impression count alone! Learn how specific metrics actually translate to video success and you'll get not only a million views, but tons of sales, as well.
Search engine optimization (SEO) is often about making small modifications to parts of your website. When viewed individually, these changes might seem like incremental improvements, but when combined with other optimizations, they could have a noticeable impact on your site's user experience and performance in organic search results. You're likely already familiar with many of the topics in this guide, because they're essential ingredients for any web page, but you may not be making the most out of them.
With 360° videos, viewers "scroll" around to see content from every angle — as if they were physically standing within the content. This spherical video style allows viewers to experience a location or event, such as exploring Antarctica or meeting a hammerhead shark. VR allows viewers to navigate and control their experience. These videos are usually viewed through devices such as Oculus Rift or Google Cardboard.
Provide full functionality on all devices. Mobile users expect the same functionality - such as commenting and check-out - and content on mobile as well as on all other devices that your website supports. In addition to textual content, make sure that all important images and videos are embedded and accessible on mobile devices. For search engines, provide all structured data and other metadata - such as titles, descriptions, link-elements, and other meta-tags - on all versions of the pages.
I first discovered Sharpe years ago online. His story was one of the most sincere and intriguing tales that any one individual could convey. It was real. It was heartfelt. It was passionate. And it was a story of rockbottom failure. It encompassed a journey that mentally, emotionally and spiritually crippled him in the early years of his life. As someone who left home at the age of 14, had a child at 16, became addicted to heroin at 20 and clean four long years later, the cards were definitely stacked up against him.
An Internet marketing campaign is not an isolated, one-off proposal. Any company that plans on using it once is certain to continue to use it. An individual who is knowledgeable about all aspects of an Internet marketing campaign and who has strong interpersonal skills is well-suited to maintain an ongoing managerial role on a dedicated marketing team.
Many of the classic SEO elements still hold a lot of weight, things like incoming links and internal structures so we're having to optimize for those but at the same time most see the writing on the wall – AI is pushing its way into the algorithm and with it an increased ability for Google to understand a user's intent and whether a page meets that intent and deliver that as a result that irrespective of many of those classic signals.
Publishing your video across all your owned channelsExtended ArticleHow to Distribute Your Video on Owned ChannelsIf you know content is king, you probably know distribution is queen. Creating amazing, engaging video content is difficult, but distributing it can be… Read More is probably the easiest way to distribute your video, and the one method that cannot be ignored. It includes every channel you own, like your website, PDFs, digital documents, email lists, ecommerce pages, apps, and more. These channels are the primary sources of information about your company and brand, so use every single one you can intelligently and with purpose.
Search queries—the words that users type into the search box—carry extraordinary value. Experience has shown that search engine traffic can make (or break) an organization's success. Targeted traffic to a website can provide publicity, revenue, and exposure like no other channel of marketing. Investing in SEO can have an exceptional rate of return compared to other types of marketing and promotion.
Small business owners sometimes think that search engine marketing (SEM), also known as pay-per-click advertising (PPC), is not lucrative option for them. They may think they can't afford it, or that their online presence is not important if they are a local or service-based business. The truth is, as search engines have undeniably become a part of our lifestyles as consumers, there are many ways to leverage them for businesses of any size. This post will introduce you to the basics and benefits of search engine marketing (SEM).
It is very rare for an individual to enter a management role early in his or her career. Most marketing managers have spent several years working somewhere else on a marketing team. This assumes the existence of at least a bachelor's degree, but an advanced degree such as a master's in marketing or business administration can give an aspiring manager a deciding edge.
One of the most enduring misconceptions about search engine marketing is that whomever has the largest advertising budget wins. Although a larger advertising budget can certainly be advantageous, especially when targeting highly competitive keywords, but it's far from a requirement for success with search engine marketing. This is because all ads go through a process known as the ad auction before appearing alongside search results. For the purposes of this explanation, we'll be focusing on the ad auction in Google AdWords.
After that, you need to make a choice about how to construct an online presence that helps you achieve that goal. Maybe you need to set up an e-commerce site. If you're interested in publishing content to drive awareness and subscribers, look into setting up a blog. A simple website or landing page with a lead capture form can help you start developing your brand and generating traffic. A basic analytics platform (like Google Analytics, which is free) can help you start to measure how you are tracking towards your initial goal.
Description meta tags are important because Google might use them as snippets for your pages. Note that we say "might" because Google may choose to use a relevant section of your page's visible text if it does a good job of matching up with a user's query. Adding description meta tags to each of your pages is always a good practice in case Google cannot find a good selection of text to use in the snippet. The Webmaster Central Blog has informative posts on improving snippets with better description meta tags18 and better snippets for your users19. We also have a handy Help Center article on how to create good titles and snippets20.
In this new world of digital transparency brands have to be very thoughtful in how they engage with current and potential customers. Consumers have an endless amount of data at their fingertips especially through social media channels, rating and review sites, blogs, and more. Unless brands actively engage in these conversations they lose the opportunity for helping guide their brand message and addressing customer concerns.


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Never before have we seen a previous president and his team openly attempt to sabotage the next president, but that is precisely what is happening. Traditionally, most ex-presidents have chosen to move far away from Washington, but Barack Obama decided to purchase a home less than two miles from the White House, and many of his former staff members are either working directly with him or are working for his political organization Organizing for Action. And of particular concern is the fact that Valerie Jarrett has actually moved into Obama's five million dollar home, which many are referring to as Obama's "anti-Trump command center". For eight years the Obamas wouldn't even sneeze without consulting Valerie Jarrett first, and needless to say Jarrett has not moved in to help them pick out wallpaper and drapes. Jarrett is a hardcore political operative, and she has reportedly convinced Obama that he needs to lead the fight against Trump. (Read More...)
Barack Obama
America Became A Lot Less Christian During The Presidency Of Barack Obama
In 2006, Barack Obama famously said that "we are no longer just a Christian nation", and after the last eight years that is now more true than ever. The Pew Research Center has just released a major report entitled "How America Changed During Barack Obama's Presidency", and what struck me the most about the report was the fact that it showed that the United States became a lot less Christian while Obama was in the White House. Of course this trend did not begin under Obama, but it seems to have accelerated during his presidency. (Read More...)
The Danger Zone: Why Israel Greatly Fears Barack Obama's Last Few Months In Office
Between right now and January 20th, 2017 is a real "pressure point" for U.S. relations with Israel. Barack Obama has always desired to "leave a legacy" in the Middle East, and at this point the only option for accomplishing anything tangible is through the United Nations. The Israeli government is extremely concerned that Obama may attempt to take such action before he leaves office, and so they recently asked Secretary of State John Kerry if the U.S. would promise to veto any anti-Israel resolutions that come before the UN Security Council for the rest of Obama's time in the White House. Unfortunately for Israel, the New York Post is reporting that Kerry flatly refused to make such a promise… (Read More...)
Why Won't Obama Call It Terrorism?
Everybody knows that what just happened in New York City was an act of Islamic terror, so why won't Barack Obama use those words? 28-year-old Afghan immigrant Ahmad Khan Rahami only had one motivation when he planted those improvised explosive devices. He wanted to use violence to promote the cause of Islam. All over the planet radical Islam is on the rise, and we have seen more than 1000 Islamic terror attacks worldwide so far this year. But an extreme form of political correctness is causing many of our leaders to deny what is happening right in front of their eyes. In fact, Barack Obama refused to use the word terrorism when talking about the attack in New York… (Read More...)
U.S. Anger At Israel Could Result In A UN Security Council Resolution Establishing A Palestinian State
The Obama administration is absolutely furious with Israel. At the end of July, the U.S. State Department issued a scathing press statement in which it publicly rebuked the government for Israel for "settlement activity" in East Jerusalem which the Obama administration considers to be "corrosive to the cause of peace". There has always been tension between the Netanyahu government and the Obama administration, but I don't know if we have ever seen the State Department use such strong language to condemn Israeli activity. Unfortunately, the rapid deterioration of the relationship between the United States and Israel could have some very serious implications for the entire region in the months ahead. As you will see below, Newsweek is reporting that France is ready to make a renewed push for a UN Security Council resolution that would formally establish a Palestinian state, and this time around the Obama administration may be ready to go along with such a resolution. (Read More...)


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You've got barrels of data. A dense 15-page whitepaper. Reams of statistically significant survey results. Presentations stuffed with charts and graphs. Content is not the issue; making it accessible and digestible is your challenge.
Content distillation—the creation of bite-sized or snackable content—involves paring down content to the vital message, giving busy readers the high-level takeaways so they don't have to read the entire document. Carefully crafted headlines and summaries can pique your customers' interest and motivate them to download the full report, white paper, or survey results.
When my daughter was working on the Common App for colleges, she had to describe each of her extracurricular activities in no more than 150 characters. [That sentence alone uses up the character count allotment.] She had to root out redundancies, carefully select the most all-encompassing adjectives, and parse sentences down to their bare bones.
However, content distillation isn't always this extreme or restrictive. One of our clients recently asked us to take 10 thought leadership papers—each 10 pages long and full of charts, graphs, and detailed copy—and write 250-word summaries for each. The idea was to create a single high-level promotion piece to hand out at a conference, encouraging attendees to download the complete papers. So, how do you write a meaningful executive summary distilling a large amount of content down to its essence? Here are some of our strategies:
If you are feeling overwhelmed by a lengthy report, overly long PowerPoint presentation, or other unwieldy beast, call the experts at the Content Bureau. Our distillation department (including yours truly) will be happy to help.


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The third captivating, sizzling Scottish historical romance in New York Times bestseller Karen Hawkins's Princes of Oxenburg series. Fans of Julia Quinn, Monica McCarty and Julie Garwood will be enchanted by this dazzling read.
A loyal Prince. A Scottish fair lady. A partnership of honour and passion.
Prince Nikolai Romanovin has journeyed to the deepest wilds of Scotland to rescue his abducted grandmother. Hiding his royal identity, the prince slips into enemy territory disguised as a groom.
Ailsa Mackenzie is in charge of Castle Cromartie - and her unruly grandmother - in her father's absence. Clever and pragmatic, nothing gets past her and she's certain her new groom isn't who he says he is. But she can't deny he stirs her senses...
After confronting her imposter, Ailsa agrees to help - for she, too, would do anything for family. Their secret partnership turns into searing kisses and soon danger awaits them. Facing an unknown enemy, Ailsa and Nik must also battle something far more perilous ... their own unruly hearts.
Don't miss the previous sublime Princes of Oxenburg books: The Prince Who Loved Me, The Prince And I and The Princess Wore Plaid. And for more unmissable Scottish historical romance, catch her amazing Duchess Diaries series.
Karen Hawkins is the New York Times bestselling author of some of the funniest and freshest Scottish romances. When not stalking hot Australian actors, getting kicked out of West Virginia thanks to the antics of her extended family, or adding to her considerable shoe collection, Karen is getting chocolate on her keyboard while writing her next delightfully fun and sexy historical romance.
Find her online at www.karenhawkins.com, follow her on Twitter @TheKarenHawkins, and on Facebook at www.facebook.com/AuthorKarenHawkins.
The Prenup is set to be THE romantic comedy hit of the summer! Perfect for fans of Jo Watson, Lindsey Kelk and Sophie Kinsella.My name is Charlotte Spencer, and ten years ago, I married my brother's best friend. I haven't seen him since. Charlotte Spencer grew up on the blue-blooded Upper East Side of Manhattan but she never wanted the sit-still-look-pretty future her parents dictated for her. Enter Colin Walsh, her brother's quiet, brooding, man-bun-sporting best friend, and with him a chance to escape. He's far from Charlotte's dream guy as but they need each other for one thing: marriage. One courthouse wedding later, Charlotte's inheritance is hers to start a business in San Francisco and Irish-born Colin has a Green Card. Ten years later, Colin drops a bombshell: the terms of their prenup states that before either can file for divorce, they have to live under the same roof for three months. Suddenly this match made in practicality is about to take on whole new meaning...Want more fun, fresh, flirty and very sexy rom-com? Check out Lauren's Oxford series and don't miss her warm, witty and sexy Wedding Belles series and the I Do, I Don't series, as well as the romantic standalones in the Love Unexpectedly series.
The Weekend begins Rhyannon Byrd's sexy new serial, London Affair, where a dangerous web of passion, deception and intrigue unfolds into an explosive love story... Perfect for fans of Sylvia Day, J. Kenner and Jodi Ellen Malpas.American art-history graduate Emmy Reed is in London, hoping to land her dream job by getting an exclusive scoop on a famous reclusive artist. When a dangerous encounter throws her into the path of millionaire playboy Jase Beckett, Emmy is grateful for his quick-thinking - but equally determined to turn down his proposal to be his date for a family wedding. That is, until she discovers that her sought-after artist is his grandfather. Tired of the game-playing women in his circle, Jase finds Emmy refreshingly fascinating. And as the weekend progresses and they work together to survive his insufferable family's devious scheming, Emmy and Jase find themselves drowning in an intoxicating sexual chemistry that leaves them both desperate for more...and reeling emotionally.When their stunning weekend is over, neither is ready to let go. But dark secrets surround the Beckett family - can their fledgling relationship survive the damaging revelations to come?Emmy and Jase's explosive London Affair continues in The Chase and The Confession.'From London to the English countryside, Jase and Emmy burn up the sheets in this first installment of Rhyannon Byrd's London Affair' P.T. Michelle, New York Times bestselling author'London Affair is signature Rhyannon Byrd - exciting, sexy, and romantic. Byrd brilliantly crafts a steamy love story with a couple that dazzles, and I couldn't put it down!' Virna DePaul, New York Times bestselling authorLooking for more sexy reads from Rhyannon Byrd? Check out the steamy Dangerous Tides titles: Take Me Under, Make Me Yours and Keep Me Closer.
CAUGHT BY THE SCOT is a fabulously witty and irresistibly sexy Scottish historical romance from New York Times bestseller Karen Hawkins. Fans of Julia Quinn, Monica McCarty and Julie Garwood will be won over by the spellbinding Made to Marry series.When the dark Duke of Hamilton loses his beloved wife, he heeds her dying wish that he make certain her three brothers marry well for she fears they are all headed to ruin. Heartsick, the Duke approaches the task with a heavy hand, ordering the three brothers to marry within three months or forego their inheritance.The middle brother, the dashing Conner Douglas, is not about to give up his independence, but he knows marriage doesn't always mean one much change, does it? If anything, being married to a pliable sort of female would give him even more opportunity to seduce the married women of the ton. So he heads straight for the most pliable female he knows - a childhood acquaintance and now mousy spinster, the English born and bred Miss Theodora Cumberbatch-Snowe.Conner is so certain Theodora will joyously agree to marry him, that he takes his time traveling to her house and has only one month to secure her hand and marry. Yet when he arrives at her parents' house he discovers that Theodora has just run away with a local landowner -- a farmer, no less! Unknown to Conner, Theodora has been wildly, passionately in love with him for years. But she's accepted he only sees her as a friend. Unable to sit forever in her parents' front parlor and wait for what will never happen, Theodora decided to marry someone comfortable in the hopes they might at least become good partners.Unaware of Theodora's feelings, Conner isn't about to let 'the perfect wife' get away so easily. But as Conner seduces Theodora, his own feelings stir. And after surviving a trip of mishaps and traps, he discovers that he can't image her marrying anyone but him.Don't miss Karen Hawkins' magnificent Princes of Oxenburg series! And catch her delightful Duchess Diaries series.
Wrecked is the new standalone novel of deliciously dark, deeply emotional contemporary romance from J. B. Salsbury, the New York Times bestselling author of Split and The Fighting Series, perfect for fans of Katy Evans, Jamie McGuire and Sophie Jackson.When you can't trust yourself, how can you ask anyone else to?It's been months since Aden Colt left the Army, and still the memories haunt him. When he moved into a tiny boat off the California coast, he thought he'd found the perfect place to escape life. Then Sawyer shows up and turns his simple life upside down. Beautiful and sophisticated, she seems out of place in this laid-back beach town. Something is pushing her to experience everything she can - including Aden. But as much as he wants her, starting a relationship with Sawyer puts them both at risk. For Aden, the past doesn't stay there; it shows up unexpectedly, uncontrollably, and doesn't care whose life it wrecks.He's not like other guys... Don't miss J. B. Salsbury's unique and explosive romance, Split, out now.
Lost And Found Sisters is the new novel from New York Times bestselling author Jill Shalvis, a story of friendship, love, family and sisterhood, for fans of Susan Mallery, Kristan Higgins and Robyn Carr.Life can change in an instant... After losing her sister in a devastating car accident, LA chef Quinn Weller seems to be getting her life back on track. So why does she feel so empty, like she's looking for a missing piece she can't find?The answer comes when a lawyer appears, revealing a bombshell secret and mysterious inheritance in the small town of Wildstone, California. On impulse, Quinn heads up the coast and finds herself drawn to Wildstone's simple pleasures...and the handsome, dark-haired stranger who offers friendship with no questions asked.But there's another surprise to come. The inheritance is something earthshattering, that will make Quinn question everything she knows about herself and her family. Now with a world of possibilities opening up, Quinn must decide if this new life is the one she was always meant to have - and could finally give her the fulfillment she's searched so long for.Check out Jill's warm, funny Heartbreaker Bay novels, visit gorgeous Cedar Ridge, spellbinding Lucky Harbor or experience some Animal Magnetism in Sunshine, Idaho in Jill's other unforgettable series.
Blackbird is the new novel from New York Times bestselling author, Molly McAdams, a dark, twisting story of redemption and true love against the odds, perfect for fans of J. B. Salsbury, Jamie McGuire, Sophie Jackson and Lisa Renee Jones, which A. L. Jackson calls, 'Consuming. Enthralling. Sexy. MIND-BLOWING.'Briar Chapman is going to be the death of me, and I don't care. I'll take every day until that death comes, and I'll welcome it when it does.On the outside, Lucas Holt is what nightmares are made of. A man cloaked in darkness, with sin-filled eyes and an enticing grin. A devil so devastatingly beautiful and cruel that his very presence instils fear.But beneath his terrifying, ever-calm exterior is an affectionate man haunted by a past that refuses to stay buried. And Lucas looks at me as though he's finally found the only person who can make it all go away.We're in a battle of the brightest day and the darkest night - and I want to lie in the wake of our war.Look for the next Redemption novel from Molly McAdams, Firefly.
Utterly enchanting, emotionally powerful and heart-stoppingly sexy - lose yourself in this Jeanette Grey romance. Nine Kinds of Naughty is perfect for fans of Christina Lauren, Jodi Ellen Malpas and Maya Banks.Lexie Bellamy can handle a boardroom. It's relationships that are a minefield. So when a business trip takes her to Spain, Lexie knows she'll have no problem closing the deal. But spending one-on-one time with her crazy-hot colleague is going to prove a challenge. At the office, Lexie calls the shots. But this trip is the perfect opportunity for Dane Huntley to show his gorgeous boss how good it can feel when someone else takes charge. . . Miles away from home, giving in to Dane is easy. But when the trip is over, Lexie is determined to return to their professional relationship. Dan has other ideas, though. He vows to prove that what they've found is real . . . and he has no intention of letting go.Totally captivated by Jeanette Grey's intoxicating romance? Don't miss Kate and Rylan's story in Seven Nights To Surrender and the sequel, Eight Ways To Ecstasy, as well as her other intensely emotional and sexy romances: When The Stars Align and Confessions In The Dark.
Sex and the City meets The Wedding Planner in To Love And To Cherish, the third witty contemporary romance in Lauren Layne's The Wedding Belles series, about three high-powered New York City women who can plan any wedding - but their own. For fans of Jill Shalvis, Julie James and Rachel Gibson.Alexis Morgan has devoted eight years to turning her tiny start-up into Manhattan's premier wedding-planning company. Now it's time to come up with a plan to tackle her personal life. Definitely not part of that plan is her silent business partner in the Wedding Belles, Logan Harris. But when a late night at the office ends with an unexpected kiss, Alexis begins to suspect there's more to Logan than just pinstripes and glasses. Logan has wanted Alexis since they met and, when Alexis needs a date for her sister's last-minute wedding in Florida, Logan sees the perfect opportunity to show her what she's been missing. As Florida's sultry days turn into even hotter nights, Logan sets out to convince Alexis that the fling of a lifetime could just maybe turn into forever... Want some fun, fresh, flirty and very sexy rom-com? Check out the titles in the Oxford series: Irresistibly Yours, I Wish You Were Mine and Someone Like You.Can a guy and a girl really be 'just friends'? You won't want to miss Lauren Layne's sexy take on this timeless question in Blurred Lines.
For fans of Debbie Macomber, Robyn Carr, Barbara Freethy and Susan Mallery. Christmas In Eternity Springs is the gorgeously heartwarming twelfth novel in New York Times bestselling author Emily March's warm and uplifting romance series about a small town with a big heart. After a devastating betrayal, Claire Branham packs up her life, along with a twenty-million-dollar secret, and moves to Eternity Springs. Opening a specialty shop - Forever Christmas - and embarking on a romance with the town's sexy new handyman, Claire's heart begins to heal. Until her past comes knocking...Jax Lancaster abandoned his career in the Navy after his ex-wife's death to give his young son the one thing he wants: a life in Eternity Springs. He just never expected a second chance at love with a fascinating woman for whom Christmas has become a business. But when the truth about Claire threatens their newfound happiness, can Jax prove to her that in Eternity Springs, the spirit of Christmas is real...and will last a lifetime?Escape to Eternity Springs, a little piece of heaven in the Colorado Rockies, with the other books in the series, Hummingbird Lake, Heartache Falls, Mistletoe Mine, Lover's Leap, Nightingale Way, Reflection Point, Miracle Road, Dreamweaver Trail, Teardrop Lane, Heartsong Cottage, Reunion Pass, Christmas In Eternity Springs.
The Trouble With Mistletoe is the second in New York Times bestselling author Jill Shalvis's Heartbreaker Bay series, featuring her trademark gift for humour, warmth and romance. Perfect for fans of Jill Mansell, Debbie Macomber, Nora Roberts and Marie Force. Is it time to give him - and love - another chance? Willa Davis is wrangling puppies when Keane Winters stalks into her pet shop, desperate to leave his great-aunt's Feline-from-Hell in someone else's capable hands. But, despite the fact that he's sure he's never seen the drop-dead-gorgeous pet-shop owner before, she definitely seems to be mad at him...The last thing Willa is inclined to do is rescue a guy who doesn't even remember her. Still, she can't deny that Keane's changed since high school - but can she trust him not to break her heart again? Maybe all she can do is throw a coin in the fountain, make a Christmas wish - and let the mistletoe do its work...Want more warm, funny romance? Check out the first Heartbreaker Bay novel, Sweet Little Lies, visit gorgeous Cedar Ridge, spellbinding Lucky Harbor or experience some Animal Magnetism in Sunshine, Idaho in Jill's other unforgettable series.
Sex and the City meets The Wedding Planner in For Better Or Worse, the second sexy contemporary romance in Lauren Layne's The Wedding Belles series. Will a budding wedding planner and her bad boy neighbour stop banging heads and start hearing wedding bells? For fans of Jill Shalvis, Julie James and Rachel Gibson.Heather Fowler is thrilled when she's promoted from assistant to Wedding Belles planner. Unfortunately, her first celebrity client demands an opulent affair at the Plaza...in three months. But what Heather finds herself really losing sleep over is the live music blaring from her playboy neighbour's apartment all night. Five years ago, Josh Tanner was a rising star on Wall Street. But a grim cancer diagnosis made him realize there's more to life than a penthouse and corner office. He kicked the cancer and dedicated his life to following his passions - the latest being to convince his pretty, workaholic neighbour to let loose too. He just doesn't expect to fall for the sweet, vulnerable woman hiding beneath the power suits. Soon it's Heather's turn to convince Josh to take the biggest risk of all: love.Want some fun, fresh, flirty and very sexy rom-com? Check out the titles in the Oxford series: Irresistibly Yours, I Wish You Were Mine and Someone Like You.Can a guy and a girl really be 'just friends'? You won't want to miss Lauren Layne's sexy take on this timeless question in Blurred Lines.


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A. Lupus is a chronic disease in which a person's body is attacked by the immune system, which normally fights infections and foreign invaders, such as viruses and bacteria, said Gilkeson, a professor of medicine at the Medical University of South Carolina in Charleston. Lupus can cause a variety of symptoms, including severe fatigue, headaches, painful or swollen joints, fever, swelling in the hands or ankles, a butterfly-shaped rash across the nose and cheeks, sensitivity to light, mouth and nose ulcers, anemia and hair loss.
Kaposi observed that lupus assumed two forms: the skin lesions (now known as discoid lupus) and a more aggravated form that affected not only the skin but also caused fever, arthritis, and other systemic disorders in people.[112] The latter also presented a rash confined to the face, appearing on the cheeks and across the bridge of the nose; he called this the "butterfly rash". Kaposi also observed those patients who developed the "butterfly rash" (or malar rash) often were afflicted with another disease such as tuberculosis, anemia, or chlorisis which often caused death.[110] Kaposi was one of the first people to recognize what is now termed systemic lupus erythematosus in his documentation of the remitting and relapsing nature of the disease and the relationship of skin and systemic manifestations during disease activity.[113]
Heart and Lungs. Heart and lung involvement often is caused by inflammation of the covering of the heart (pericardium) and lungs (pleura). When these structures become inflamed, patients may develop chest pain, irregular heartbeat, and accumulation of fluid around the lungs (pleuritis or pleurisy) and heart (pericarditis). The heart valves and the lung itself can also be affected by lupus, resulting in shortness of breath.
MRI (or magnetic resonance imaging) scan is a radiology technique which uses magnetism, radio waves, and a computer to produce images of body structures. MRI scanning is painless and does not involve X-ray radiation. Patients with heart pacemakers, metal implants, or metal chips or clips in or around the eyes cannot be scanned with MRI because of the effect of the magnet.
Proteinuria (also called albuminuria or urine albumin) is a condition in which urine contains an abnormal amount of protein. Albumin is the main protein in the blood. Proteins are the building blocks for all body parts, including muscles, bones, hair, and nails. Proteins in the blood also perform a number of important functions. They protect the body from infection, help blood clot, and keep the right amount of fluid circulating throughout the body.
Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). PGA is often assessed by a single question with a 0–10 or 0–100 response. The content can vary and relates either to global health (e.g., how is your health overall) or to disease activity (e.g., how active is your arthritis).
Peer review is the first stage of our grant decision-making process. All applications received are reviewed by top experts in the field, to determine whether or not those studies show great promise. After all, we only want to scrutinize the best projects most carefully. This crucial first step allows only the projects that have tremendous scientific merit and hold great promise for preventing, treating, and curing lupus, to advance to the second stage of the review process. That second stage is a process managed by our Scientific Advisory Board, where they take all of the top scoring applications, scrutinize them very carefully, and then make recommendations to our Board of Directors, for which ones we are actually going to fund.
Blood—hematologic disorder—hemolytic anemia (low red blood cell count), leukopenia (white blood cell count<4000/µl), lymphopenia (<1500/µl), or low platelet count (<100000/µl) in the absence of offending drug; sensitivity = 59%; specificity = 89%.[75] Hypocomplementemia is also seen, due to either consumption of C3[76] and C4 by immune complex-induced inflammation or to congenitally complement deficiency, which may predispose to SLE.
Rate of SLE varies between countries from 20 to 70 per 100,000.[2] Women of childbearing age are affected about nine times more often than men.[4] While it most commonly begins between the ages of 15 and 45, a wide range of ages can be affected.[1][2] Those of African, Caribbean, and Chinese descent are at higher risk than white people.[4][2] Rates of disease in the developing world are unclear.[6] Lupus is Latin for "wolf": the disease was so-named in the 13th century as the rash was thought to appear like a wolf's bite.[7]
Disease-modifying antirheumatic drugs (DMARDs) are used preventively to reduce the incidence of flares, the progress of the disease, and the need for steroid use; when flares occur, they are treated with corticosteroids. DMARDs commonly in use are antimalarials such as hydroxychloroquine and immunosuppressants (e.g. methotrexate and azathioprine). Hydroxychloroquine is an FDA-approved antimalarial used for constitutional, cutaneous, and articular manifestations. Hydroxychloroquine has relatively few side effects, and there is evidence that it improves survival among people who have SLE.[83] Cyclophosphamide is used for severe glomerulonephritis or other organ-damaging complications. Mycophenolic acid is also used for treatment of lupus nephritis, but it is not FDA-approved for this indication, and FDA is investigating reports that it may be associated with birth defects when used by pregnant women.[86]
There is a wide range of diets advertised to help you lose weight quickly or control various chronic diseases, such as lupus. Many people claim to be experts in nutrition yet have limited knowledge and offer no protection to the public. You should be wary of unqualified practitioners who may be offering unproven techniques to diagnose and treat nutritional problems.
As you've possibly experienced, your doctor is not going to provide you with a healing regime so you must find your way to learning how to work with your body in a healing crisis. There are many, many answers that will support you in reducing your lupus symptoms, even reversing them altogether. Your diet for lupus should be the first line of defense.
Neonatal lupus erythematosus (NLE) can develop in the babies of mothers with antibodies to SSA/Ro. Neonates with NLE can present with rash around 4-6 weeks of life, elevated liver function test results, thrombocytopenia around 1-2 weeks of life, neutropenia, and hydrocephalus. [141] NLE can also manifest as a congenital atrioventricular conduction block, [142] with as many as 1-5% of pregnancies in mothers with anti- SSA/SSB antibodies leading to heart block, rising to a 6-25% risk for subsequent pregnancies after one affected child is born. [143]
Next, Ms. Everett reviewed some of the key foods that are important for your diet. She emphasized that balance is essential – that is, to not eat too much of one thing and not enough of another. Different foods have different nutritional components. Included in the important foods that Ms. Everett highlighted were a variety of fruits and vegetables; foods low in calories and saturated fats; and foods high in antioxidants, fiber, calcium, vitamin D, and Omega 3 fatty acids.
For resistant skin disease, other antimalarial drugs, such as chloroquine (Aralen) or quinacrine, are considered and can be used in combination with hydroxychloroquine. Alternative medications for skin disease include dapsone and retinoic acid (Retin-A). Retin-A is often effective for an uncommon wart-like form of lupus skin disease. For more severe skin disease, immunosuppressive medications are considered as described below.
There is no cure for SLE.[1] Treatments may include NSAIDs, corticosteroids, immunosuppressants, hydroxychloroquine, and methotrexate.[1] Alternative medicine has not been shown to affect the disease.[1] Life expectancy is lower among people with SLE.[5] SLE significantly increases the risk of cardiovascular disease with this being the most common cause of death.[4] With modern treatment about 80% of those affected survive more than 15 years.[3] Women with lupus have pregnancies that are higher risk but are mostly successful.[1]
Whether you're dealing with lupus, rheumatoid arthritis, Hashimoto's or one of the hundreds of other autoimmune conditions out there, you have the power to beat your symptoms, regain your energy, and feel like yourself again. By following these steps to uncover the root cause of your illness, you CAN reverse your disease and live a life full of optimal health!
Lupus in children tends to be more aggressive than in adults, says Dr. Pascual. The exact reasons for this are not understood. One theory is that people are born with genetic susceptibility to the disease that may be triggered by environmental factors such as a virus. "Children with the condition may have inherited a more complex set of predisposing genes," she says. But this theory has yet to be proved.
Limitations of the test: Like CRP, the ESR is not specific to lupus. Because there are many causes for a positive result, including infection, the test is not diagnostic for lupus. Nor can it distinguish a lupus flare from an infection. Also, the level doesn't directly correlate with lupus disease activity. So it isn't necessarily useful for monitoring disease activity.
Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.
Lupus is an inflammatory autoimmune disease that can affect multiple parts of the body including the various organ systems. Doctors prescribe traditional pharmaceutical medications to manage symptoms and prevent flare ups of the disease that can cause more serious problems and complications. Many patients choose to supplement their pharmaceutical care with alternative treatments and lifestyle adjustments like using diet and exercise to minimize lupus symptoms. We discuss this further in our blog, Lupus/Chronic Illness: The Mind/Body Connection. There exists two major diets widely discussed in the autoimmune world. One is the anti-inflammatory diet and one is called the Paleo Diet.
Autoantibodies directed against various nuclear antigens including DAutoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease. Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Neonatal lupus Technically neonatal lupus is not a form of lupus. The condition is the result of autoantibodies passing from a pregnant woman with lupus (or related condition) through the placenta and to the baby developing in the womb, causing mostly temporary symptoms, explains Virginia Pascual, MD, the director of the Gale and Ira Drukier Institute for Children's Health at Weill Cornell Medicine in New York City. Some infants are born with symptoms, such as skin rash, liver problems, or white blood cell counts. But those symptoms disappear within a few months and leave no lasting effects.
Lupus Erythematosus is a chronic autoimmune disease that causes the immune system to attack one's body. The disease is characterized by the inflammation of various healthy tissues and organs in the body, including the joints, skin, kidneys, heart, lungs, blood vessels and brain. The severity of the disease may vary because no two cases of lupus are exactly alike.
Lupus disease, especially when active, could lead to accelerated atherosclerosis (clogging of the arteries) which can develop in young women and could also lead to heart attacks, heart failure, and strokes. Thus, it is vital that patients with lupus, in addition to controlling their disease, exercise and lower other risk factors for heart disease, such as smoking, high blood pressure, and high cholesterol.
Granulocytes and monocytes, collectively called myeloid cells, are differentiated descendants from common progenitors derived from hematopoietic stem cells in the bone marrow. Commitment to either lineage of myeloid cells is controlled by distinct transcription factors followed by terminal differentiation in response to specific colony-stimulating factors and release into the circulation. Upon pathogen invasion, myeloid cells are rapidly recruited into local tissues via various chemokine receptors, where they are activated for phagocytosis as well as secretion of inflammatory cytokines, thereby playing major roles in innate immunity.
How an autoimmune disease affects you depends on what part of the body is targeted. If the disease affects the joints, as in rheumatoid arthritis, you might have joint pain, stiffness, and loss of function. If it affects the thyroid, as in Graves' disease and thyroiditis, it might cause tiredness, weight gain, and muscle aches. If it attacks the skin, as it does in scleroderma/systemic sclerosis, vitiligo, and systemic lupus erythematosus (SLE), it can cause rashes, blisters, and color changes.
Gluten can also lead to what's known as molecular mimicry. The gluten protein, gliadin, resembles many of your body's own tissues, particularly thyroid tissue. If you have Celiac disease, gluten intolerance, or a leaky gut, your immune system releases gliadin antibodies every time you eat gluten. Because gliadin looks so similar to your own tissues, sometimes these antibodies mistakenly attack other organs and systems, from the skin to the thyroid to the brain. This case of mistaken identity often leads to full-blown autoimmune disease.
We acknowledge as a limitation that certainty of the evidence was not as high as desirable for most recommendations and probably biased by few randomised clinical trials. Although regional information was published on several topics1 4 10 11 23 24 31–49 we recognise that these guidelines should be updated as research-based changes in our understanding of SLE emerge. Regardless, the publication of these guidelines must be followed by health system engagement and implementation by specialists, major steps towards improvement of lupus treatment in Latin America and low/middle-income countries.
SLE is an autoimmune disease involving multiple organ systems, a clinical pattern of flares and remissions, and the presence of anti-nuclear autoantibodies. Whereas early symptoms most frequently involve the skin and joints, disease morbidity and mortality are usually associated with cardiovascular events and damage to major organs, particularly the kidneys. Many of the current therapeutic options are considered to be inadequate because of toxicities, accrual of organ damage, and insufficient control of the underlying disease pathology. Improved understanding of SLE pathogenesis and immunology has led to the identification of new treatment targets. Current interest is mainly focused on the targeted immunosuppressive actions provided by biologic therapy. Although the potential long-term beneficial or harmful effects of the new molecular treatments are unclear, their precise molecular targeting may reveal key relationships within the immune system and advance the cause of individualized molecular medicine.
Over half of the people with SLE develop a characteristic red, flat facial rash over the bridge of their nose. Because of its shape, it is frequently referred to as the "butterfly rash" of SLE. The rash is painless and does not itch. The facial rash, along with inflammation in other organs, can be precipitated or worsened by exposure to sunlight, a condition called photosensitivity. This photosensitivity can be accompanied by worsening of inflammation throughout the body, called a "flare" of the disease.
An adverse event that results in death, is life-threatening, requires inpatient hospitalization or extends a current hospital stay, results in an ongoing or significant incapacity or interferes substantially with normal life functions, or causes a congenital anomaly or birth defect. Medical events that do not result in death, are not life-threatening, or do not require hospitalization may be considered serious adverse events if they put the participant in danger or require medical or surgical intervention to prevent one of the results listed above.
Aseptic meningitis is a disease caused by the inflammation of the protective membranes covering the brain and spinal cord known as the meninges. Unlike other forms of meningitis, aseptic meningitis is not caused by infection and cannot be spread person-to-person. Instead it can be caused by lupus, cancers, certain drugs, head injury, and brain surgery, among others. Meningitis is characterized by a sudden onset of fever, headache, and stiff neck. It is often accompanied by other symptoms, such as nausea, vomiting, photophobia (sensitivity to light), and altered mental status (confusion).
Peer review is the first stage of our grant decision-making process. All applications received are reviewed by top experts in the field, to determine whether or not those studies show great promise. After all, we only want to scrutinize the best projects most carefully. This crucial first step allows only the projects that have tremendous scientific merit and hold great promise for preventing, treating, and curing lupus, to advance to the second stage of the review process. That second stage is a process managed by our Scientific Advisory Board, where they take all of the top scoring applications, scrutinize them very carefully, and then make recommendations to our Board of Directors, for which ones we are actually going to fund.
A. Lupus is a chronic disease in which a person's body is attacked by the immune system, which normally fights infections and foreign invaders, such as viruses and bacteria, said Gilkeson, a professor of medicine at the Medical University of South Carolina in Charleston. Lupus can cause a variety of symptoms, including severe fatigue, headaches, painful or swollen joints, fever, swelling in the hands or ankles, a butterfly-shaped rash across the nose and cheeks, sensitivity to light, mouth and nose ulcers, anemia and hair loss.
I tend to stay away from garlic, never used alfalfa. I know most restaurants will use garlic but when cooking at home, I leave it out and find other seasonings that make food taste good as well. I am more plant-based and cook in more than eating out to keep a better feel for what I'm putting in my body. I do still enjoy a glass of wine once a week or so. I initially did a food elimination phase and that helped me figure out what works for my body. Its been a couple of years and I am actually about to do another one since converting over from vegetarian to plant-based means a few different food options and of course our bodies are always changing their minds about how they want to respond to things.
Systemic lupus erythematosus is a chronic, recurrent, potentially fatal multisystem inflammatory disorder that can be difficultto diagnose.1,2 The disease has no single diagnostic marker; instead, it is identified through a combination of clinical and laboratory criteria.3 Accurate diagnosis of systemic lupus erythematosus is important because treatment can reduce morbidity4–11 and mortality,12 particularly from lupus nephritis. This article reviews evidence-based recommendations for the diagnosis of systemic lupus erythematosus by primary care physicians.
In 2007, the European League Against Rheumatism (EULAR) released recommendations for the treatment of SLE. [61] In patients with SLE without major organ manifestations, glucocorticoids and antimalarial agents may be beneficial. [61] NSAIDs may be used for short periods in patients at low risk for complications from these drugs. Consider immunosuppressive agents (eg, azathioprine, mycophenolate mofetil, methotrexate) in refractory cases or when steroid doses cannot be reduced to levels for long-term use. [106]
Rates of positive ANA tests are affected by the prevalence of systemic lupus erythematosus in the population. Specifically, false-positive rates will be higher in populations with a low prevalence of the disease, such as primary care patients. Because of the high false-positive rates at 1:40 dilution, ANA titers should be obtained only in patients who meet specific clinical criteria (discussed in the clinical recommendations section of this article). When ANA titers are measured, laboratories should report ANA levels at both 1:40 and 1:160 dilutions and should supply information on the percentage of normal persons who are positive at each dilution.41
An intravenous pyelogram (IVP) is a special x-ray examination of the kidneys, bladder, and ureters (the tubes that carry urine from the kidneys to the bladder). An intravenous pyelogram is performed by injecting contrast material into a vein in the arm. A series of x-rays are taken at timed intervals as the contrast material goes through the kidneys, the ureters, and the bladder. The procedure helps to evaluate the condition of those organs.
"I have had severe lupus for over twenty years and find that diet doesn't really change any symptoms. I eat meat, fish, dairy, gluten and sugar too…all in moderation. I eat lots of fruit and veg and avoid processed foods. The only thing I avoid is alcohol. I guess everyone is different but a well-balanced, healthy diet with exercise (when I'm up to it) is my formula."
According to Goldman Foung, "A diet rich in vegetables gives me energy and keeps me feeling strong and healthy." She typically eats meals filled with dark leafy greens and other colorful vegetables, eats lots of whole grains, and limits her consumption of meat and processed foods. "I also try to drink fresh-pressed beet juice as often as possible," she adds. "It's a great way to sneak in some of those body-boosting ingredients."
Anitphospholipid Antibodies (APLs): Phospholipids are antibodies that are present in approximately one out of every two people with lupus. A positive test can help confirm diagnosis as well as help identify women with lupus who have certain risks (like blood clots and miscarriage) that would require preventative treatment and monitoring. Note that the presence of phospholipids also occurs in people without lupus and therefore, there presence alone is not enough for a lupus diagnosis.
People with lupus should know that most rashes, and sometimes other symptoms, are aggravated by sun exposure, so you'll want to avoid it or use sun protection. It's critical to talk to your doctor about skin rashes and lesions that you observe, as many are treated differently, and some can be signs that the disease is progressing or changing. You may need other treatments, too.
Dermatomyositis. Acute onset of confluent macular erythema in a periorbital and malar distribution (involving the cheeks and extending over the nasal bridge), with extension to the chin in a female with juvenile dermatomyositis. Note the perioral sparing. In some patients, there may be more extensive involvement of the face, including the perioral region, forehead, lateral face, and ears. In contrast to SLE , in dermatomyositis with malar erythema, the nasolabial folds are often not spared.
Since other diseases and conditions appear similar to lupus, adherence to classification can greatly contribute to an accurate diagnosis. However, the absence of four of these criteria does not necessarily exclude the possibility of lupus. When a physician makes the diagnosis of SLE, s/he must exclude the possibility of conditions with comparable symptoms, including rheumatoid arthritis, systemic sclerosis (scleroderma), vasculitis, dermatomyositis and arthritis caused by a drug or virus.
Over half of the people with SLE develop a characteristic red, flat facial rash over the bridge of their nose. Because of its shape, it is frequently referred to as the "butterfly rash" of SLE. The rash is painless and does not itch. The facial rash, along with inflammation in other organs, can be precipitated or worsened by exposure to sunlight, a condition called photosensitivity. This photosensitivity can be accompanied by worsening of inflammation throughout the body, called a "flare" of the disease.
The panel concluded that long-term IS agents during maintenance therapy prolong stable renal function, reduce proteinuria, extend renal survival and minimise the toxicity of GCs. AZA, CYC, MMF and CsA seem to be equivalent regarding efficacy but MMF and AZA have a better safety profile, particularly regarding gonadal toxicity and blood pressure control. We found very low certainty of the evidence for TAC as maintenance therapy, with studies mostly restricted to Asian populations.
Corticosteroids also can cause or worsen osteoporosis, a disease in which bones become fragile and more likely to break. If you have osteoporosis, you should eat foods rich in calcium every day to help with bone growth. Examples are dark green, leafy vegetables (spinach, broccoli, collard greens), milk, cheese, and yogurt or calcium supplements that contain Vitamin D.
In addition to the 11 criteria, other tests can be helpful in evaluating people with SLE to determine the severity of organ involvement. These include routine testing of the blood to detect inflammation (for example, the erythrocyte sedimentation rate, or ESR, and the C-reactive protein, or CRP), blood-chemistry testing, direct analysis of internal body fluids, and tissue biopsies. Abnormalities in body fluids (joint or cerebrospinal fluid) and tissue samples (kidney biopsy, skin biopsy, and nerve biopsy) can further support the diagnosis of SLE. The appropriate testing procedures are selected for the patient individually by the doctor.
Get involved in your care. Learn as much as you can about lupus, your medications, and what kind of progress to expect. Take all your medications as your doctor prescribes, and visit your rheumatologist often to prevent serious problems. This lets your doctor keep track of your disease and change your treatment as needed. If you do not live near a rheumatologist, you may need to have your primary care doctor manage your lupus with the help of a rheumatologist.
Affiliate Disclosure: There are links on this site that can be defined as affiliate links. This means that I may receive a small commission (at no cost to you) if you purchase something when clicking on the links that take you through to a different website. By clicking on the links, you are in no way obligated to buy.
Please Note: The material on this site is provided for informational purposes only and is not medical advice. Always consult your physician before beginning any diet or exercise program.
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"Orente" hit maker, Adekunle Gold feature in Nollywood movies for the second time.
Two days ago, He announced the news via his gram page, shared the artwork of the new movie titled "Mentally" and wrote;
In my 2nd movie feature, I'm introducing 'Skuri' - one of my alter-egos. Bit by bit, Nollywood is becoming my comfort zone 💪🏾 Watchout for MENTALLY.
Adekunle hinted that He might be taking a switch to Nollywood maybe in the nearest future, joining the likes of Banky W and Chidinma who were artistes turned actors after He said "Bit by bit, Nollywood is becoming my comfort zone"
New Movie, Mentally featuring Frank Donga @frankdonga_, Yaw @yawnaija Adekunle Gold @adekunlegold and others, directed by James Abinibi @abinibi, is set to hit Nigerian cinemas soon.


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Though similar in appearance to the older costumes, this Batsuit is unique in and that it possesses a much larger amount of gadgetry than any other costume shown to date. Thus far, the Batsuit has been shown to not only contain multiple batarangs and other standard Bat-paraphernalia, but also a collapsible sword, wings, deep space gear, scuba equipment, and multiple rocket thrusters. Also, the emblem on Batman's chest can now transform into an emergency Batarang, becoming hard and rigid after being exposed to some sort of magnetic field emitted by the suit.
who lives a life as Peter and Spider-Man. They also used the same characters as before, such as: Peter's Aunt May, J. Jonah Jameson: Editor of the Daily Bugle, Betty Brant: Jameson's secretary and classic damsel in distress, and later on during the series, Robbie Robertson, Jameson's assistant. Spidey also faces some of his usual foes such as: Green Goblin, Doctor Octopus, Mysterio and the Chameleon. This also included a six part story arc where Spidey goes up against Doctor Doom throughout the series. Spidey was voiced by Ted Schwartz in this series.
This distraction was all the Vulture needed to equip his suit and began attacking Spider-Man and the FBI. While Spider-Man saved the agents from the arms dealer's attacks, Vulture freed his men and urged them to escape. Another fierce fight ensued between the Vulture and Spider-Man, who used his Web-Shooters' combinations to enhance his fighting ability against the winged menace.
In the recent Spider-Girl storyline "Brand New May", Peter has uncovered a lab, within it is a stasis tank containing an exact physical symbiote duplicate of Mayday Parker, with notes left behind by Norman Osborn suggesting she is the real Mayday, and not a clone. When protecting his nephew Normie from an exploding test tube, Peter is affected by the serum within much like Osborn was...and begins to develop erratic behavior. He ultimately overcomes an attempt by Norman Osborn to control his mind and defeats him with the aid of his daughter, her clone, and the spirit of his Aunt May.
^ Jump up to: a b c d Manning, Matthew K.; Gilbert, Laura, ed. (2012). "1970s". Spider-Man Chronicle Celebrating 50 Years of Web-Slinging. Dorling Kindersley. p. 72. ISBN 978-0756692360. Writer Gerry Conway and artist Ross Andru introduced two major new characters to Spider-Man's world and the Marvel Universe in this self-contained issue. Not only would the vigilante known as the Punisher go on to be one of the most important and iconic Marvel creations of the 1970s, but his instigator, the Jackal, would become the next big threat in Spider-Man's life.
Two years have passed, and Peter Parker struggles to cope with the demands of life as a college student, a Daily Bugle photographer, and a crime-fighting superhero. But it hasn't gotten any easier. Condemned by the press, tormented by secrets he can never reveal, forced to give up the girl of his dreams—at times the lonely burden of Spider-Man seems almost too great to bear... and the temptation to give up grows stronger by the hour.
Welcome to the end of the page. Well, not really the end of the page, because have we got something for you! In some ways, it's the start. The HalloweenCostumes.com How-To section! We want to go the extra mile and make sure you have some tips and tricks to help you get the most out of your costume experience. Whether it's a little help selecting from our vast selection of costumes, or just a lightbulb moment to help make your costume all the better, we're here for ya! So, keep on scrolling to check out some of our curated choices of the top Halloween costumes for men. It might be exactly what you need for that little extra inspiration to have the best Halloween ever!
The array of devices Batman carries have become more complex over time. The simple coiled rope and Batarang scaling equipment became a rocket-powered (or compressed air powered) grapple gun. The suit has also carried on different occasions a re-breather device, flash and gas grenades, explosives and a detonator, lockpicks, a signaling device for the Batmobile, electronic surveillance equipment (including video camera and monitor), a forensic kit for gathering crime scene evidence, a medical kit, a cache of money and, in early incarnations, a pistol in a holster. On any occasion where Batman anticipates encountering Kryptonians, he has also carried (in a lead case) a Kryptonite Ring, given to him by Superman as a weapon of last resort.
We all know zombies are sick. But in the case of this Zombie Sk8r Child Costume, "sick" is a good thing! They'll have more steeze than any other dude at the skate park. And he or she be just waiting for everyone else to bail. Which let's face it, they are sure to do because, being alone at night in a skate park, with a zombie is just a bit sketchy.
Thinking about spooky Halloween classics? From creepy clowns to dapper skeletons to vampire hosts—it'll be a monster mash when you take a look at the 2018 Halloween Costumes we have to offer. Become a stalwart warrior king ready to fight ferocious dragons, a brave member of the armed forces, or a famous video game character from tons of different eras. It's also simple to get a great costume based off of recent and classic movies and television shows like Elf, the Addams Family, Dr. Seuss, and the Wizard of Oz. It's all right here.
Robert Downey, Jr., Josh Brolin, Mark Ruffalo, Tom Hiddleston, Chris Hemsworth, Chris Evans, Chris Pratt, Elizabeth Olsen, Zoe Saldana, Karen Gillan, Sebastian Stan, Benedict Cumberbatch, Benedict Wong, Tom Holland, Paul Bettany, Vin Diesel, Terry Notary, Dave Bautista, Bradley Cooper, Sean Gunn, Pom Klementieff, Benicio del Toro, Anthony Mackie, Scarlett Johansson, Chadwick Boseman, Danai Gurira, Don Cheadle, Tom Vaughan-Lawlor, Letitia Wright, Winston Duke, Cobie Smulders, Gwyneth Paltrow , Ethan Dizon, Tiffany Espensen, Jacob Batalon, Isabella Amara, Florence Kasumba, Terry Notary, Carrie Coon, Michael James Shaw, Peter Dinklage, Idris Elba, William Hurt, Samuel L. Jackson, Kerry Condon, Ross Marquand, Stan Lee, Stephen McFeely
^ Jump up to: a b Manning, Matthew K.; Gilbert, Laura, ed. (2012). "1960s". Spider-Man Chronicle Celebrating 50 Years of Web-Slinging. Dorling Kindersley. p. 25. ISBN 978-0756692360. The Amazing Spider-Man #13 saw [Stan] Lee and [Steve] Ditko return to the creation of new super villains. This issue marked the debut of Mysterio, a former special effects expert named Quentin Beck.
Of course, Marty went to the past and then Back to the Future, and if you're all about this top franchise of the 80s, you're going to want to set your sights on this Marty costume from the first movie. With the shirt, jacket, and vest (that looks suspiciously like a life preserver to the people of 1955), this costume set also includes some cool prop accessories that are sure to make you feel like a resident of Hill Valley—in any era!
Jump up ^ Jackson, Jeanne L. (1 January 1995). Red Letter Days: The Christian Year in Story for Primary Assembly. Nelson Thornes. p. 158. ISBN 9780748719341. Later, it became the custom for poorer Christians to offer prayers for the dead, in return for money or food (soul cakes) from their wealthier neighbours. People would go 'souling' - rather like carol singing - requesting alms or soul cakes: 'A soul, a soul, a soul cake, Please to give us a soul cake, One for Peter, two for Paul, have mercy on us Christians all.'


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Showing content with the highest reputation on 02/28/2013 in all areas
10 pointsIs this a thread about training or car parking?
6 pointsMitch Clark & Trenners doing repeat sprints. Both look to pull up well apart from Mitch gasping for air. Good signs
6 points[censored] me i thought this was a footy forum???
5 pointsI think it's unlikely we would've been able to secure Hogan with pick 3, Toumpas with pick 4, Dawes and Barry with pick whatever (13/20) and Viney with pick 27, if Hogan was eligible to play this year. In short, the whole deal we structured was probably based, at least in part, on Hogan not playing this year. This being the case, particularly given the spectre of cheating that seems (wholly unfairly) to hang over this club, I think we should probably just accept what we willingly and knowingly signed up to a few months back. That said, I love the look of the bloke and wholly accept Ben Hur's view that this guy is going to be a superstar, the likes of which this club has not seen for decades.
3 pointsI'd love to see a win or two before the season proper starts. I'm a big beleiver in going into the start of the season with some momentum. Something we haven't done in probably a decade.
3 points
2 pointsViney, Grimes, Toumpas, Trengrove, McDonald, Dawes, Clark, Jones, Watts All strike me as young men with their heads screwed on right and born leaders, each looking like developing into really good footballers, if they're not already. Dawes in particular has blown me away by being just about the most intelligent footballer I've ever had the pleasure of hearing being interviewed. Is it just me or does our long term future appear much brighter this year? Even if we're still due for some more pain in the short term...
2 pointsBig call. We're 3 players short of that in my opinion Quality small forward Quality small back Absolute gun midfielder
2 pointsMy team for this week Strauss Davis Sellar Dunn Gillies MacDonald Taggart M Jones Tynon Kent Pederson Tapscott Davey Fitzpatrick Barry Spencer Magner Couch Clisby, Stark, McKenzie, Nicholson, Evans, Terlich I don't care about this game, protect the players that should be playing round one, give some fringe players a chance to stake their claim. Week 3 and 4 go in full strength.
2 pointsBehind the precinct hotel
2 pointsPosters should be aware that anyone seeking to respond to Ms. Wilson's work are liable to be attacked for being "childish" and "sexist". It's one way in which people who are too lazy (or simply unable) to respond to genuine criticism of her work deflect the real issues involved with the shoddy agenda based journalism we get from Caro these days.
2 pointsThe game against Port in Renmark doesn't mean much to me because it is still too far away from the season proper, is played in belting heat, and the newbies, young'ns, and rookies will make up the majority of the team. We will get better measures of foot skills, sure hands, playing to instruction etc... but I can't see the game being used to assess whether we can actually win. The NAB cup round 3 game will be more important as we see which players are being genuinely considered and which players have already cemented a spot.
2 pointsAs much as it would be great to see Hoges running around in the seniors this year, I just don't see the need in rushing him. We aren't pushing for finals, so why not let him develop his body strength and conditioning whilst playing at Casey? Everyone could see that Majak Daw had talent, but north have let him develop his game and his body in the VFL and he is now ready to explode onto the scene now. We should have learnt our lesson with what happened to Watts. Sure Hoges appears to be ready and certainly has more agro than Watts did, but he just turned 18, he is still very much a kid. I just don't see the need to risk exposing him prematurely. Just as I wouldn't want Clark or Trengove rushed back into the side for round 1. 2013 will hopefully be a better year than last, but it's 2014 when I think we will start to seriously entertain the idea of pushing for finals. A fit Clark, Dawes and a raring to go Hogan next summer is what I want to see.
2 pointsYes it does, it explains it clearly. Just because you can't join the dots doesn't mean that it isn't an explanation. Honestly, your inability to take Logic Point A and Logic Point B, and mix them together to get a reasoned argument still amazes me after 8 years.
2 pointsNo, that would be stupid, a waste of time and resources.
2 pointsGreat practice. If you can play sport, we'll fast track your citizenship. If you're not, you can rot in Nauru etc.
2 pointsI have maintained throughout that people who were once close to the club undermined it during the course of the tanking investigation. Given that it is now common knowledge that four such people (all former employees) gave their version of the "vault" to Clothier and Haddad that proposition would seem self-evident. The club's interests were undermined by the evidence they gave. That is a fact and not a smear. I am not suggesting they lied but it's clear that others gave different evidence.My information is that at a particular point in time (September/October) the enquiry was going nowhere and was indeed in danger of folding. I have been informed that the "vault" information was voluntarily provided to the investigation by a former employee and the consequences were that the investigators recalled all witnesses and a number of different versions of the vault story entailed. As we know, despite the different versions, both the AFL and the MFC had advice from their respective senior counsel that the "tanking" case against the club had little likelihood of success in court. The "vault" evidence was therefore crucial to the ultimate outcome (convoluted as it was). I was also told that whoever informed the investigation of that story gave that information to Wilson as well. In addition, I know several people connected with the club (past or present) were privy to what Wilson knew and what the AFL knew and that there was a difference between the two stories. This connects Wilson directly to this group of people and the informants to the investigation. One other matter suggested was that the person who "squealed" to Wilson had previously supplied her with information about a different matter which was designed to embarrass the club and which subsequently proved to be untrue. Do you really believe that Wilson came about information which led her to produce her damning opinion pieces aimed at the club, Cameron Schwab and Chris Connolly and suggesting that all would be heavily punished from friendly or benign sources? The story and its back stories ring true with me and suggest there are people with past associations with the club who have continuing grievances with individuals at the club which might undermine the club's interests in the future. Please note that contrary to what you might think, I am not pointing to a specific person or even a group of people: they could come from a number of groups with past associations with the club who might be disgruntled. However, based on what I know, there are more people involved than just the four disgruntled former employees out of thirty witnesses who gave the "evidence" upon which the AFL made its decision notwithstanding that its clear that the club did not breach the AFL's tanking laws which was what the investigation was supposed to be about.
2 pointsI agree RPFC There seems to be a united view that those who have left are the main ones who have spoken. As I have previously stated it is hard to tell lies to a professional interogator at an arranged meeting. Stories told may not have been for bitter reasons and may merely have just provided information. It is then twisted into propagander by Wilson et al. I hate the way we are eager to accuse and incite hatred to those that worked for us or served in a voluntary role on the board. Sure some arent happy but that doesnt mean they are working against us. It works against us as a club if we dont let it go.
1 pointI agree, Roost It. Nathan Jones is a quality player, but if he wants to win a flag, he'd be hoping for at LEAST one midfielder a class above him on the team, and probably two.
1 pointI can't see the current footy dept recruiting anything other than outstanding young men. At long last there's a system in place and a criteria to work against.
1 pointIf the club doesn't win a flag with this crop of youngster, it never will.
1 pointLeaving aside Brendan Fevola a couple of years ago, Casey has done well in the past with "no name" recruits who make good in the VFL. Best comes from the Leongatha Parrots and is a 22 year old goalkicking half forward. It will be interesting to see if he takes up the offer to join the Scorps. Cranbourne ruckman/key defender Michael Boland has also signed.
1 pointYep, more than happy to admit my tail is longer than most of the other teams'. Boult and Herath are both capable of scoring a quickfire 30 off about 25 balls, but overall it's definitely a long tail. Unlike others, I don't have someone at 8 who's capable of lasting a while to complement the top order. Haddin I'm not worried about - his current form is good, and he wasn't dropped for form (although he should have been...). Given where I got him in the draft, I was happy with that.
1 pointhttp://www.theage.com.au/afl/afl-news/waiting-game-20130226-2f4at.html Perfect example why hogan shouldn't play this year. dont agree with it. Just let him learn his trade, develope his body and strength and get his confidence up and going. I can bet my left plum he will make a sudden impact next year and hit the ground running if he is developed through the VFL this year
1 pointAnyone up for this...? We promise not to send players for early surgery, and instead, they play the entire VFL finals series. We invest around $14,700 with above-mentioned betting agency. Casey wins the flag. We pay off our $500k fine.
This leaderboard is set to Melbourne/GMT+11:00


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Tile Painting Kitchen
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Gorgeous, 4BR/3.5BA, Cape Cod Style Home On Desirable Corner Lot, Close To Schools, Shopping & Mins To Beach!!! - **NOTE: PHOTOS TAKEN PRIOR TO NEW CARPET INSTALLED PROPERTY DETAILS: * 4BR/3.5BA * Approx. 3000 SQ FT * 2-Car Garage + 2 Spots In Front Of Garages * Private & Spacious Yard w/ Playset & Patio Area w/ Sunshade * Incredible 1st Floor Great Room Living Space w/ 3 Living Areas w/ Fireplaces & Grand Foyer * Huge, Open Kitchen w/ Granite Countertops/Island, All Stainless Steel Appliances (Oven, Cooktop w/Hood, D/W, Microwave & Refrig) & Dining Nook * Spacious Master w/Walk-In Closet, Large Windows Overlooking Yard & Luxurious Bath w/Dual Sinks, Tub & Large Shower * Bright & Large 2nd, 3rd & 4th Bedrooms w/ Wall Closets * Spacious Desk Area w/Two Workstations & Built-In Bookshelves * Beautiful Hardwood Throughout, New Carpeting & Tile * Central Vac, Fully Wired Security System & Whole-House Water Filter w/Reverse Osmosis Faucet In Kitchen * Laundry Room w/ W/D, Sink & Lots of Cabinet Space * Gardener Pd - Tenant Pays All Other Utilities * No Smoking & No Pets ***AVAILABLE NOW*** SHOWN BY APPT ONLY
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Help David save Madison schools!
Well played, sir!
WI State Journal: Question — "Is the city on the best course for the Madison public market?"
Mayoral candidate Nick Hart: Answer —"I don't care."
Do You Know Where Your Candidate Stands on the Madison Police Department? Use This Handy Tool
Following the school to prison pipeline
Roaming the hallways
Residential Burglary – 9:39 p.m. Monday 2-11-19: Officers responded to the 500 block of N. Frances St for a report of 4-5 juveniles (AAMs) roaming hallways of an apartment complex. It was reported that a backpack was missing and the group of juveniles was confronted by residents. The juveniles fled on foot and are at-large. A backpack with electronics was determined to be missing.
Three stolen cars! 3!
02-10-19 — Fitchburg police and other law enforcement agencies had a busy time chasing after three stolen vehicles Sunday night, with the driver of one of the vehicles found and arrested.
Jermaine Coleman, 17, Madison, was taken into custody and tentatively charged with operating a vehicle without the owner's consent, hit and run and felony bail jumping, Fitchburg police said.
The whole episode started in Belleville at about 6:30 p.m. Sunday, when a caller to 911 said their vehicle had been stolen.
Mitch Henck boosts Blaska for school board
Daily Archives: December 1, 2018
A truly decent man has died
That would be George Bush Sr. Resquiat in pacem. Advertisements
Posted in Uncategorized Tagged George Bush Sr., George Herbert Walker Bush, Tommy Thompson 8 Comments