text:
Solution to the colloidal silica problem in the San Luis Potosi power plant; Solucion del problema de silice coloidal en la central termoelectrica San Luis Potosi
Energy Technology Data Exchange (ETDEWEB)
Lopez Rubalcava, Humberto [Comision Federal de Electricidad (CFE), Mexico, D. F. (Mexico); Mercado, Sergio [Instituto de Investigaciones Electricas, Cuernavaca (Mexico); Guerra, Protasio [Comision Federal de Electricidad (CFE), Mexico, D. F. (Mexico)
In June 1986 the Comision Federal de Electricidad (CFE) made tests to raise the load of the first normalized unit of 350 MW of the San Luis Potosi Power Plant; although the new system for colloidal silica removal had not yet been installed, consisting of a hollow fibers ultra-filtration system with a capacity of 110 m{sup 3}, that for the first time would be applied in a Mexican power plant. It was decided to install this system due to the fact that the well water supplying this power plant comes from a geothermal reservoir, with water at 38 degrees Celsius and a silica content of 15 to 250 parts per billion (ppb) of colloidal silica, which makes it necessary to eliminate it in order to enable the boiler operation at its design conditions (175 bars (2573 psig) and 540 degrees Celsius). Although a demineralizing plant existed for the boiler feed water make up, the ion exchange resins were not able to retain the colloidal silica. Also, the First Unit operation was held at 25% of its rated capacity; in trying to raise the output to 50%, the silica concentration in the boiler water went over the allowed limits, resulting in a concentration of 1,500 ppb in the boiler water and 28 ppb in the steam. One the ultra-filtration plant was installed, the power plant operated at full rated capacity with silica concentrations in the steam lower than the permitted concentration, i.e. 10 ppb . By the end of 1987 the Second Unit of 350 MW was put into operation with the ultra-filtration system in operation, reaching full load without any problem. Once confirmed the efficiency of the ultra-filtration for the colloidal silica removal, CFE will apply this system in other power plants of the country having the same problem. [Espanol] En junio de 1986, la Comision Federal de Electricidad (CFE) efectuo pruebas de elevacion de carga en la primera unidad normalizada de 350 MW de la central termoelectrica San Luis Potosi; sin embargo, aun no se terminaba de instalar el nuevo sistema para la
Application of Cs-137 techniques to problems of sediment redistribution in Sungai Lui representative basin, Selangor, Malaysia (Part 1)
International Nuclear Information System (INIS)
Daud bin Mohamad.
Since the beginning of the nuclear age, Cesium-137 has become a part of the world's ecosystems. Cs-137 is carried from the atmosphere to the ground by rainfall. On reaching the earth's surface, 137 Cs becomes strongly adsorbed to soil profiles and is concentrated predominantly in the surface layer, particularly in clayey soils. Systematic measurements of Cs-137 levels will therefore permit estimates to be made of the cumulative effects of soil redistribution over the past 25 years. Sediment movement in river catchments and coastal areas is a very old problem in Malaysia. In view of rapid development of urban and agricultural areas in Malaysia it was realised tha soil loss problems are particularly serious. The Sungai Lui catchment was chosen to be the investigational site. Geologically, the area comprises of granite and granitic schist. The area is mostly covered by forest (approx. 83%) and rubber (13%), padi (2%) and others (2%). The climate is considered to be typical of Peninsular Malaysia (equatorial) characterised by uniform temperature, high humidity and high rainfall. The area is mainly drained by the Lui River. Soil samples were collected from the catchment area at 4 sampling points in April 1981. The results of analyses of Cs-137 in soil samples from Sungai Lui catchment area ranged from 1.3 to 6.8 M Bq g -1 of sample and they could still be detected even up to 20 cm depth. A general pattern of Cs-137 distribution was observed in the soil profile at each site. The highest activity being in the top 3 cm layer and then decreasing up to about 6 cm. The activity increases again up to about 9 cm layer. From there onwards, it decreases. Based on these results, the estimated rate of sediment accumulation in the area was found to be about 0.47 cm/year. Since the samples were only collected from the depositional sites, further sampling especially from erosional site should therefore be carried out in order to obtain more complete data
[Violence against women in transnational communities in San Luis Potosí, Mexico: a public health problem].
Flores, Yesica Yolanda Rangel
Violence against women is a worldwide problem due to its impact on quality of life for those living under the complicity of a patriarchal culture and a state that makes such violence invisible. This article aims to give visibility to the contexts of violence affecting female "partners of migrants" in their places of origin, problematizing how such violence assaults their physical and mental health. This was a qualitative study with an interpretative anthropological focus, drawing on a sample of 21 women from rural and urban areas in San Luis Potosí, Mexico. Interviews were based on daily life history and discourse analysis. According to the results, women experience more violence when their spouses migrate, new forms of violence are committed against them, and the violence occurs in both the household and the community. Violence against women is a public health problem that should be treated through a framework that is sensitive to the social and cultural dynamics characterizing the contexts in which health programs are implemented.
Effectiveness of discovery learning model on mathematical problem solving
Herdiana, Yunita; Wahyudin, Sispiyati, Ririn
This research is aimed to describe the effectiveness of discovery learning model on mathematical problem solving. This research investigate the students' problem solving competency before and after learned by using discovery learning model. The population used in this research was student in grade VII in one of junior high school in West Bandung Regency. From nine classes, class VII B were randomly selected as the sample of experiment class, and class VII C as control class, which consist of 35 students every class. The method in this research was quasi experiment. The instrument in this research is pre-test, worksheet and post-test about problem solving of mathematics. Based on the research, it can be conclude that the qualification of problem solving competency of students who gets discovery learning model on level 80%, including in medium category and it show that discovery learning model effective to improve mathematical problem solving.
El ensayo de interpretación del ser nacional: su problemática y el caso de 'Nosotros' de Luis López de Mesa
Directory of Open Access Journals (Sweden)
Juan Camilo Galeano
Full Text Available Este texto se divide en dos partes: la primera aborda el ensayo de interpretación del ser nacional, las voces que lo han desarrollado en América Latina y cuestiona la falta de reconocimiento de este género en Colombia. La segunda considera a Luis López de Mesa: partiendo de su obra De cómo se ha formado la nación colombiana, analiza las estrategias literarias de las que éste se vale en Nosotros para mostrar la identidad antioqueña como resultado de una debacle moral. En el desarrollo del análisis se encuentra que la industrialización de Antioquia hizo mundanos su valores humanos.
Effects of Problem-Solving, Guided-Discovery and Expository ...
African Journals Online (AJOL)
This study investigated the relative effectiveness of problem-solving, guideddiscovery, and expository methods of instruction on students performance in redox reaction, considering their mathematics ability. It was a quasiexperimental research using non-randomized-pre-test post-test control group design with expository ...
Two combinatorial optimization problems for SNP discovery using base-specific cleavage and mass spectrometry.
Chen, Xin; Wu, Qiong; Sun, Ruimin; Zhang, Louxin
The discovery of single-nucleotide polymorphisms (SNPs) has important implications in a variety of genetic studies on human diseases and biological functions. One valuable approach proposed for SNP discovery is based on base-specific cleavage and mass spectrometry. However, it is still very challenging to achieve the full potential of this SNP discovery approach. In this study, we formulate two new combinatorial optimization problems. While both problems are aimed at reconstructing the sample sequence that would attain the minimum number of SNPs, they search over different candidate sequence spaces. The first problem, denoted as SNP - MSP, limits its search to sequences whose in silico predicted mass spectra have all their signals contained in the measured mass spectra. In contrast, the second problem, denoted as SNP - MSQ, limits its search to sequences whose in silico predicted mass spectra instead contain all the signals of the measured mass spectra. We present an exact dynamic programming algorithm for solving the SNP - MSP problem and also show that the SNP - MSQ problem is NP-hard by a reduction from a restricted variation of the 3-partition problem. We believe that an efficient solution to either problem above could offer a seamless integration of information in four complementary base-specific cleavage reactions, thereby improving the capability of the underlying biotechnology for sensitive and accurate SNP discovery.
Serendipity in the Stacks: Libraries, Information Architecture, and the Problems of Accidental Discovery
Carr, Patrick L.
Serendipity in the library stacks is generally regarded as a positive occurrence. While acknowledging its benefits, this essay draws on research in library science, information systems, and other fields to argue that, in two important respects, this form of discovery can be usefully framed as a problem. To make this argument, the essay examines…
The Prehistory of Discovery: Precursors of Representational Change in Solving Gear System Problems.
Dixon, James A.; Bangert, Ashley S.
This study investigated whether the process of representational change undergoes developmental change or different processes occupy different niches in the course of knowledge acquisition. Subjects--college, third-, and sixth-grade students--solved gear system problems over two sessions. Findings indicated that for all grades, discovery of the…
GeoGebra Assist Discovery Learning Model for Problem Solving Ability and Attitude toward Mathematics
Murni, V.; Sariyasa, S.; Ardana, I. M.
This study aims to describe the effet of GeoGebra utilization in the discovery learning model on mathematical problem solving ability and students' attitude toward mathematics. This research was quasi experimental and post-test only control group design was used in this study. The population in this study was 181 of students. The sampling technique used was cluster random sampling, so the sample in this study was 120 students divided into 4 classes, 2 classes for the experimental class and 2 classes for the control class. Data were analyzed by using one way MANOVA. The results of data analysis showed that the utilization of GeoGebra in discovery learning can lead to solving problems and attitudes towards mathematics are better. This is because the presentation of problems using geogebra can assist students in identifying and solving problems and attracting students' interest because geogebra provides an immediate response process to students. The results of the research are the utilization of geogebra in the discovery learning can be applied in learning and teaching wider subject matter, beside subject matter in this study.
Directory of Open Access Journals (Sweden)
Rafael Maya
Full Text Available Entre los poetasa del Centenario tuvo Luis Carlos López mucha popularidad en el extranjero, desde la publicación de su primer libro. Creo que su obra llamó la atención de filósofos como Unamuno y, si no estoy equivocado, Darío se refirió a ella en términos elogiosos. En Colombia ha sido encomiada hiperbólicamente por algunos, a tiemp que otros no le conceden mayor mérito.
Problem Formulation in Knowledge Discovery via Data Analytics (KDDA) for Environmental Risk Management.
Li, Yan; Thomas, Manoj; Osei-Bryson, Kweku-Muata; Levy, Jason
With the growing popularity of data analytics and data science in the field of environmental risk management, a formalized Knowledge Discovery via Data Analytics (KDDA) process that incorporates all applicable analytical techniques for a specific environmental risk management problem is essential. In this emerging field, there is limited research dealing with the use of decision support to elicit environmental risk management (ERM) objectives and identify analytical goals from ERM decision makers. In this paper, we address problem formulation in the ERM understanding phase of the KDDA process. We build a DM³ ontology to capture ERM objectives and to inference analytical goals and associated analytical techniques. A framework to assist decision making in the problem formulation process is developed. It is shown how the ontology-based knowledge system can provide structured guidance to retrieve relevant knowledge during problem formulation. The importance of not only operationalizing the KDDA approach in a real-world environment but also evaluating the effectiveness of the proposed procedure is emphasized. We demonstrate how ontology inferencing may be used to discover analytical goals and techniques by conceptualizing Hazardous Air Pollutants (HAPs) exposure shifts based on a multilevel analysis of the level of urbanization (and related economic activity) and the degree of Socio-Economic Deprivation (SED) at the local neighborhood level. The HAPs case highlights not only the role of complexity in problem formulation but also the need for integrating data from multiple sources and the importance of employing appropriate KDDA modeling techniques. Challenges and opportunities for KDDA are summarized with an emphasis on environmental risk management and HAPs.
Problem Formulation in Knowledge Discovery via Data Analytics (KDDA for Environmental Risk Management
Directory of Open Access Journals (Sweden)
Yan Li
Full Text Available With the growing popularity of data analytics and data science in the field of environmental risk management, a formalized Knowledge Discovery via Data Analytics (KDDA process that incorporates all applicable analytical techniques for a specific environmental risk management problem is essential. In this emerging field, there is limited research dealing with the use of decision support to elicit environmental risk management (ERM objectives and identify analytical goals from ERM decision makers. In this paper, we address problem formulation in the ERM understanding phase of the KDDA process. We build a DM3 ontology to capture ERM objectives and to inference analytical goals and associated analytical techniques. A framework to assist decision making in the problem formulation process is developed. It is shown how the ontology-based knowledge system can provide structured guidance to retrieve relevant knowledge during problem formulation. The importance of not only operationalizing the KDDA approach in a real-world environment but also evaluating the effectiveness of the proposed procedure is emphasized. We demonstrate how ontology inferencing may be used to discover analytical goals and techniques by conceptualizing Hazardous Air Pollutants (HAPs exposure shifts based on a multilevel analysis of the level of urbanization (and related economic activity and the degree of Socio-Economic Deprivation (SED at the local neighborhood level. The HAPs case highlights not only the role of complexity in problem formulation but also the need for integrating data from multiple sources and the importance of employing appropriate KDDA modeling techniques. Challenges and opportunities for KDDA are summarized with an emphasis on environmental risk management and HAPs.
Problem Formulation in Knowledge Discovery via Data Analytics (KDDA) for Environmental Risk Management
Li, Yan; Thomas, Manoj; Osei-Bryson, Kweku-Muata; Levy, Jason
With the growing popularity of data analytics and data science in the field of environmental risk management, a formalized Knowledge Discovery via Data Analytics (KDDA) process that incorporates all applicable analytical techniques for a specific environmental risk management problem is essential. In this emerging field, there is limited research dealing with the use of decision support to elicit environmental risk management (ERM) objectives and identify analytical goals from ERM decision makers. In this paper, we address problem formulation in the ERM understanding phase of the KDDA process. We build a DM3 ontology to capture ERM objectives and to inference analytical goals and associated analytical techniques. A framework to assist decision making in the problem formulation process is developed. It is shown how the ontology-based knowledge system can provide structured guidance to retrieve relevant knowledge during problem formulation. The importance of not only operationalizing the KDDA approach in a real-world environment but also evaluating the effectiveness of the proposed procedure is emphasized. We demonstrate how ontology inferencing may be used to discover analytical goals and techniques by conceptualizing Hazardous Air Pollutants (HAPs) exposure shifts based on a multilevel analysis of the level of urbanization (and related economic activity) and the degree of Socio-Economic Deprivation (SED) at the local neighborhood level. The HAPs case highlights not only the role of complexity in problem formulation but also the need for integrating data from multiple sources and the importance of employing appropriate KDDA modeling techniques. Challenges and opportunities for KDDA are summarized with an emphasis on environmental risk management and HAPs. PMID:27983713
Keefektifan setting TPS dalam pendekatan discovery learning dan problem-based learning pada pembelajaran materi lingkaran SMP
Directory of Open Access Journals (Sweden)
Rahmi Hidayati
The purpose of this study was to describe the effectiveness of setting Think Pair Share (TPS in the approach to discovery learning and problem-based learning in terms of student achievement, mathematical communication skills, and interpersonal skills of the student. This study was a quasi-experimental study using the pretest-posttest nonequivalent group design. The research population comprised all Year VIII students of SMP Negeri 1 Yogyakarta. The research sample was randomly selected from eight classes, two classes were elected. The instrument used in this study is the learning achievement test, a test of mathematical communication skills, and interpersonal skills student questionnaires. To test the effectiveness of setting Think Pair Share (TPS in the approach to discovery learning and problem-based learning, the one sample t-test was carried out. Then, to investigate the difference in effectiveness between the setting Think Pair Share (TPS in the approach to discovery learning and problem-based learning, the Multivariate Analysis of Variance (MANOVA was carried out. The research findings indicate that the setting TPS discovery approach to learning and problem-based approach to learning (PBL is effective in terms of learning achievement, mathematical communication skills, and interpersonal skills of the students. No difference in effectiveness between setting TPS discovery approach to learning and problem-based learning (PBL in terms of learning achievement, mathematical communication skills, and interpersonal skills of the students. Keywords: TPS setting in discovery learning approach, in problem-based learning, academic achievement, mathematical communication skills, and interpersonal skills of the student
76 FR 10945 - San Luis Trust Bank, FSB, San Luis Obispo, CA; Notice of Appointment of Receiver
... DEPARTMENT OF THE TREASURY Office of Thrift Supervision San Luis Trust Bank, FSB, San Luis Obispo, CA; Notice of Appointment of Receiver Notice is hereby given that, pursuant to the authority... appointed the Federal Deposit Insurance Corporation as sole Receiver for San Luis Trust Bank, FSB, San Luis...
La problemática del género literario: una lectura de El río, novelas de caballería de Luis Cardoza y Aragón
Rodríguez Cascante, Francisco; Universidad de Costa Rica
El presente trabajo examina brevemente, en una primera parte, las concepciones del género literario en Aristóteles, Oscar Tacca, Roberto Fernández Retamar, Hans Robert Jauss, Mijaíl Bajtín y Roland Barthes. Luego, en una segunda parte, se efectúa una discusión de esta categoría en un estudio de caso: una aproximación al texto autobiográfico El río, novelas de caballería del escritor guatemalteco Luis Cardoza y Aragón
Usability Study Identifies Vocabulary, Facets, and Education as Primary Primo Discovery System Interface Problems
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Ruby Muriel Lavallee Warren
efficiently. Again, all eight participants found an article on the requested subject in Test 1, Task 2, but two were unable to determine if the article met peer review requirements. One participant used the peer-reviewed journals facet, while the rest attempted to determine this using the item record or with facilitator help. All seven participants in Test 2 were able to locate the book requested in Task 1 via title search, but most had difficulty determining what steps to take to check that book out. Five participants completed Test 2, Task 2 (finding a newspaper article on a topic unassisted, one completed it with assistance, and one could not complete it at all. Five users did not notice the Newspaper Articles facet, and no participants noticed resource type icons without facilitator prompting. Conclusions – The researchers, while noting that there were few experienced researchers and a narrow scope of disciplines in their sample, concluded that there were a number of clear barriers to successful research in the Primo interface. Participants rarely used post-search facets, although they used pre-search filtering when possible, and ignored links and tabs within search results in favour of clicking on the material's title. This led to users missing helpful tools and features. They conclude that a number of the usability problems with Primo's interface are standard discovery systems usability problems, and express concern that this has been inadequately addressed by vendors. They also note that a number of usability issues stemmed from misunderstandings of terminology, such as "peer-reviewed" or "citation". They conclude that while they have been able to make several improvements to their Primo interface, such as adding an author limiter and changing "Peer-reviewed Journals" to "Peer-reviewed Articles", further education of users will be the only way to solve many of these usability problems.
The effect of discovery learning and problem-based learning on middle school students' self-regulated learning
Miatun, A.; Muntazhimah
The aim of this research was to determine the effect of learning models on mathematics achievement viewed from student's self-regulated learning. The learning model compared were discovery learning and problem-based learning. The population was all students at the grade VIII of Junior High School in Boyolali regency. The samples were students of SMPN 4 Boyolali, SMPN 6 Boyolali, and SMPN 4 Mojosongo. The instruments used were mathematics achievement tests and self-regulated learning questionnaire. The data were analyzed using unbalanced two-ways Anova. The conclusion was as follows: (1) discovery learning gives better achievement than problem-based learning. (2) Achievement of students who have high self-regulated learning was better than students who have medium and low self-regulated learning. (3) For discovery learning, achievement of students who have high self-regulated learning was better than students who have medium and low self-regulated learning. For problem-based learning, students who have high and medium self-regulated learning have the same achievement. (4) For students who have high self-regulated learning, discovery learning gives better achievement than problem-based learning. Students who have medium and low self-regulated learning, both learning models give the same achievement.
Luis Alvarez, the Hydrogen Bubble Chamber, Tritium, and Dinosaurs
Dinosaurs Resources with Additional Information * Patents Luis Alvarez Courtesy Lawrence Berkeley National JFK Assassination, and the End of the Dinosaurs Memorial Tribute for Luis W. Alvarez The Fruitful and Luis Alvarez (1911 - 1988) Why Dinosaurs Are Extinct Berkeley Scientists Report First Evidence that
33 CFR 110.120 - San Luis Obispo Bay, Calif.
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, Calif. 110... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.120 San Luis Obispo Bay, Calif. (a) Area A-1. Area A-1 is the water area bounded by the San Luis Obispo County wharf, the shoreline, a line drawn...
Hombres: Doctor Luis Ángel Arango
Directory of Open Access Journals (Sweden)
Boletín Cultural y Bibliográfico Banco de la República
Full Text Available En el documento se realiza la nota de conmemoración del fallecimiento del Doctor Luis Ángel Arango Esta nota tiene como fin realizar un homenaje a tan reputado ciudadano colombiano y mienbro de la comunidad de funcionarios del Banco de la República.
Teresa y Luis, Luis y Teresa. Dos santos en tiempos recios
Directory of Open Access Journals (Sweden)
Emilio Callado Estela
Full Text Available El presente artículo analiza la relación entre dos grandes santos españoles de la Contrarreforma Católica, Teresa de Jesús y el dominico fray Luis Bertrán. The present article analyses the relation between two big Spanish saints of the Catholic Counterreformation, Teresa de Jesus and the Dominican monk Luis Bertrán.
Problems in the Science and Mathematics of 'The Logic of Scientific Discovery'
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Alan B. Whiting
Full Text Available Professor Sir Karl Popper (1902-1994 was one of the most influential philosophers of science of the twentieth century. However, in his most famous work 'The Logic of Scientific Discovery' he displays troubling misunderstandings of science and mathematics at a basic level. These call into question his conclusions concerning the philosophy of science. Quanta 2012; 1: 13–18.
Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development
Greef, J. van der; Adourian, A.; Muntendam, P.; McBurney, R.N.
Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain.
Western Regional Conference on Testing Problems (7th, Los Angeles, California, March 14, 1958). Testing for the Discovery and Development of Human Talent.
Educational Testing Service, Los Angeles, CA.
At the seventh Western Regional Conference on Testing Problems, the following speeches were given: (1) "A Guidance Person's Approach to Testing for the Discovery and Development of Human Talent" by Frances D. McGill; (2) "The Instructional Uses of Measurement in the Discovery and Development of Human Talent" by Roy P. Wahle; (3) "New Frontiers of…
A petroleum discovery-rate forecast revisited-The problem of field growth
Drew, L.J.; Schuenemeyer, J.H.
A forecast of the future rates of discovery of crude oil and natural gas for the 123,027-km2 Miocene/Pliocene trend in the Gulf of Mexico was made in 1980. This forecast was evaluated in 1988 by comparing two sets of data: (1) the actual versus the forecasted number of fields discovered, and (2) the actual versus the forecasted volumes of crude oil and natural gas discovered with the drilling of 1,820 wildcat wells along the trend between January 1, 1977, and December 31, 1985. The forecast specified that this level of drilling would result in the discovery of 217 fields containing 1.78 billion barrels of oil equivalent; however, 238 fields containing 3.57 billion barrels of oil equivalent were actually discovered. This underestimation is attributed to biases introduced by field growth and, to a lesser degree, the artificially low, pre-1970's price of natural gas that prevented many smaller gas fields from being brought into production at the time of their discovery; most of these fields contained less than 50 billion cubic feet of producible natural gas. ?? 1992 Oxford University Press.
Luis Alvarez - a personal approach to physics
Energy Technology Data Exchange (ETDEWEB)
One of the major pioneer figures and outstanding personalities of particle physics, Luis Alvarez, died on 1 September. In addition to his numerous particle physics achievements, he became famous for his ventures in archaeology, palaeontology, and astronomy, and for his inventions. As a tribute to this remarkable man, we publish here some extracts from 'Adventures in Nuclear Physics', given as the 1962 University of California Faculty Research Lecture. According to custom, this presentation is a personalized account rather than an impersonal scientific discourse.
Scaling the walls of discovery: using semantic metadata for integrative problem solving.
Manning, Maurice; Aggarwal, Amit; Gao, Kevin; Tucker-Kellogg, Greg
Current data integration approaches by bioinformaticians frequently involve extracting data from a wide variety of public and private data repositories, each with a unique vocabulary and schema, via scripts. These separate data sets must then be normalized through the tedious and lengthy process of resolving naming differences and collecting information into a single view. Attempts to consolidate such diverse data using data warehouses or federated queries add significant complexity and have shown limitations in flexibility. The alternative of complete semantic integration of data requires a massive, sustained effort in mapping data types and maintaining ontologies. We focused instead on creating a data architecture that leverages semantic mapping of experimental metadata, to support the rapid prototyping of scientific discovery applications with the twin goals of reducing architectural complexity while still leveraging semantic technologies to provide flexibility, efficiency and more fully characterized data relationships. A metadata ontology was developed to describe our discovery process. A metadata repository was then created by mapping metadata from existing data sources into this ontology, generating RDF triples to describe the entities. Finally an interface to the repository was designed which provided not only search and browse capabilities but complex query templates that aggregate data from both RDF and RDBMS sources. We describe how this approach (i) allows scientists to discover and link relevant data across diverse data sources and (ii) provides a platform for development of integrative informatics applications.
Computational science and re-discovery: open-source implementation of ellipsoidal harmonics for problems in potential theory
International Nuclear Information System (INIS)
Bardhan, Jaydeep P; Knepley, Matthew G
We present two open-source (BSD) implementations of ellipsoidal harmonic expansions for solving problems of potential theory using separation of variables. Ellipsoidal harmonics are used surprisingly infrequently, considering their substantial value for problems ranging in scale from molecules to the entire solar system. In this paper, we suggest two possible reasons for the paucity relative to spherical harmonics. The first is essentially historical—ellipsoidal harmonics developed during the late 19th century and early 20th, when it was found that only the lowest-order harmonics are expressible in closed form. Each higher-order term requires the solution of an eigenvalue problem, and tedious manual computation seems to have discouraged applications and theoretical studies. The second explanation is practical: even with modern computers and accurate eigenvalue algorithms, expansions in ellipsoidal harmonics are significantly more challenging to compute than those in Cartesian or spherical coordinates. The present implementations reduce the 'barrier to entry' by providing an easy and free way for the community to begin using ellipsoidal harmonics in actual research. We demonstrate our implementation using the specific and physiologically crucial problem of how charged proteins interact with their environment, and ask: what other analytical tools await re-discovery in an era of inexpensive computation?
Luis Alvarez - a personal approach to physics
International Nuclear Information System (INIS)
One of the major pioneer figures and outstanding personalities of particle physics, Luis Alvarez, died on 1 September. In addition to his numerous particle physics achievements, he became famous for his ventures in archaeology, palaeontology, and astronomy, and for his inventions. As a tribute to this remarkable man, we publish here some extracts from 'Adventures in Nuclear Physics', given as the 1962 University of California Faculty Research Lecture. According to custom, this presentation is a personalized account rather than an impersonal scientific discourse
Neuroimaging Features of San Luis Valley Syndrome
Directory of Open Access Journals (Sweden)
Matthew T. Whitehead
Full Text Available A 14-month-old Hispanic female with a history of double-outlet right ventricle and developmental delay in the setting of recombinant chromosome 8 syndrome was referred for neurologic imaging. Brain MR revealed multiple abnormalities primarily affecting midline structures, including commissural dysgenesis, vermian and brainstem hypoplasia/dysplasia, an interhypothalamic adhesion, and an epidermoid between the frontal lobes that enlarged over time. Spine MR demonstrated hypoplastic C1 and C2 posterior elements, scoliosis, and a borderline low conus medullaris position. Presented herein is the first illustration of neuroimaging findings from a patient with San Luis Valley syndrome.
Voice and Valency in San Luis Potosi Huasteco
Munoz Ledo Yanez, Veronica
This thesis presents an analysis of the system of transitivity, voice and valency alternations in Huasteco of San Luis Potosi (Mayan) within a functional-typological framework. The study is based on spoken discourse and elicited data collected in the municipalities of Aquismon and Tancanhuitz de Santos in the state of San Luis Potosi, Mexico. The…
33 CFR 80.1130 - San Luis Obispo Bay, CA.
... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false San Luis Obispo Bay, CA. 80.1130 Section 80.1130 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1130 San Luis Obispo Bay, CA. A line drawn from...
[Discovery-based teaching and learning strategies in health: problematization and problem-based learning].
Cyrino, Eliana Goldfarb; Toralles-Pereira, Maria Lúcia
Considering the changes in teaching in the health field and the demand for new ways of dealing with knowledge in higher learning, the article discusses two innovative methodological approaches: problem-based learning (PBL) and problematization. Describing the two methods' theoretical roots, the article attempts to identify their main foundations. As distinct proposals, both contribute to a review of the teaching and learning process: problematization, focused on knowledge construction in the context of the formation of a critical awareness; PBL, focused on cognitive aspects in the construction of concepts and appropriation of basic mechanisms in science. Both problematization and PBL lead to breaks with the traditional way of teaching and learning, stimulating participatory management by actors in the experience and reorganization of the relationship between theory and practice. The critique of each proposal's possibilities and limits using the analysis of their theoretical and methodological foundations leads us to conclude that pedagogical experiences based on PBL and/or problematization can represent an innovative trend in the context of health education, fostering breaks and more sweeping changes.
Keisri madrusest impeeriumi esivedurijuhiks / Lui Pikkov ; kommenteerinud Hans Treimann
Pikkov, Lui, 1935-2008
Lui Pikkov oma onust Otto Piksarist (Pikkov), kes sündis Raplamaal Saunakülas, oli madruseks Nikolai II jahtlaeval Poljarnaja Zvezda, töötas vedurijuhina Eestis, oli Eesti NSV Ülemnõukogu saadik
Port San Luis, California Tsunami Forecast Grids for MOST Model
National Oceanic and Atmospheric Administration, Department of Commerce — The Port San Luis, California Forecast Model Grids provides bathymetric data strictly for tsunami inundation modeling with the Method of Splitting Tsunami (MOST)...
Discovery of dominant and dormant genes from expression data using a novel generalization of SNR for multi-class problems
Directory of Open Access Journals (Sweden)
Chung I-Fang
Full Text Available Abstract Background The Signal-to-Noise-Ratio (SNR is often used for identification of biomarkers for two-class problems and no formal and useful generalization of SNR is available for multiclass problems. We propose innovative generalizations of SNR for multiclass cancer discrimination through introduction of two indices, Gene Dominant Index and Gene Dormant Index (GDIs. These two indices lead to the concepts of dominant and dormant genes with biological significance. We use these indices to develop methodologies for discovery of dominant and dormant biomarkers with interesting biological significance. The dominancy and dormancy of the identified biomarkers and their excellent discriminating power are also demonstrated pictorially using the scatterplot of individual gene and 2-D Sammon's projection of the selected set of genes. Using information from the literature we have shown that the GDI based method can identify dominant and dormant genes that play significant roles in cancer biology. These biomarkers are also used to design diagnostic prediction systems. Results and discussion To evaluate the effectiveness of the GDIs, we have used four multiclass cancer data sets (Small Round Blue Cell Tumors, Leukemia, Central Nervous System Tumors, and Lung Cancer. For each data set we demonstrate that the new indices can find biologically meaningful genes that can act as biomarkers. We then use six machine learning tools, Nearest Neighbor Classifier (NNC, Nearest Mean Classifier (NMC, Support Vector Machine (SVM classifier with linear kernel, and SVM classifier with Gaussian kernel, where both SVMs are used in conjunction with one-vs-all (OVA and one-vs-one (OVO strategies. We found GDIs to be very effective in identifying biomarkers with strong class specific signatures. With all six tools and for all data sets we could achieve better or comparable prediction accuracies usually with fewer marker genes than results reported in the literature using the
Embarazo en la adolescencia: su comportamiento en San Luis Pregnancy in adolescence: its behavior in San Luis municipality
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Dania Rangel Díaz
Full Text Available Introducción: El embarazo en las edades tempranas, sin la adecuada preparación biológica y psicológica, trae al contraste una serie de dificultades y problemas. Objetivo: Evaluar el comportamiento del embarazo en la adolescencia en el municipio de "San Luis" durante el período 2005-2010. Material y método: Se realizó una investigación aplicada partiendo de los conocimientos teóricos y prácticos. A partir de la metodología cuantitativa se presenta un diseño longitudinal, retrospectivo, analítico y descriptivo. Se utilizó como universo (2165 todas las mujeres embarazadas desde enero de 2005 a diciembre del año 2010; la muestra la constituyeron todas las embarazadas adolescentes (405 pertenecientes al municipio San Luis. Las técnicas y procedimientos de obtención de la información fue a través de la revisión documental. Se hizo una minuciosa revisión de las historias clínicas y de la información que se guarda en archivo del departamento de genética municipal y se recolectaron datos como: la edad materna, causa del embarazo, ocupación, las enfermedades presentadas durante el embarazo, el peso al nacer y el abandono escolar. Se utilizó el método empírico empleando la media porcentual como medida de tendencia central para variables cualitativas. Resultados: Predominan las adolescentes entre 16 y 18 años de edad, todas estudiantes; la principal causa del embarazo fue el desconocimiento. Se realizó una captación precoz al mayor porciento de ellas; como la enfermedad asociada predominó la hipertensión arterial. Conclusiones: Se logró un peso adecuado al final de la gestación y en su mayoría las estudiantes no continuaron los estudios.Introduction: pregnancy in early ages, without sufficient biological and psychological preparation, brings about a series of difficulties and problems. Objective: to assess the behavior of pregnancy in adolescence in "San Luis" municipality during a five-year period (2005
Jorge Luis Borges at two final judgments
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Gustavo Ponciano Cunha de Oliveira
Full Text Available Em 1988, Beatriz Sarlo propõe uma passagem entre duas poéticas em Jorge Luis Borges: de Evaristo Carriego (1930 em direção a Historia universal de la infamia (1935. Os dois textos são "insidiosos", defende a pesquisadora, porque falsificam as biografias de seus personagens. Porém, a coletânea de 1935 opera em âmbito universal. Este movimento, afirma Sarlo, é portador de um acumulo de prerrogativas, associado à dupla inscrição de Borges: o cidadão do mundo e, simultaneamente, o de um país pensado a partir de Buenos Aires. Neste ensaio, sugerimos uma passagem anterior, evidenciada em "Sentirse en muerte" (1928: do criollismo – o poeta dos arrabaldes, dotado da capacidade de transporte sensível e instalado nos limites de sua cidade imaginada, que busca a representação poética digna de seu conceito de argentinidade – em direção à prosa que alcança o caráter argumentativo-reflexivo dos ensaios sobre o tempo e a eternidade característicos de Borges, início de sua legitimação como "percibidor abstracto del mundo". Este movimento é também portador de um acúmulo de prerrogativas, dupla inscrição de Borges: como poeta, literato e ensaísta programático do criollismo; como meditador dedicado aos assombros contidos em nossos conceitos de vida, tempo e universo, operador de textos da Filosofia e da Teologia.
[Dr. Luis Cifuentes Delatte. Memories and teaching].
Pérez Albacete, Mariano
With the celebration of the centenary of the birth of Dr. Luis Cifuentes Delatte, due to his great scientific personality, we want to emphasize two features that, taken from his works and memories, we consider have not been emphasized enough: his role as historian of urology, both for the histories he narrated of his life experiences and the historical exposition of several pathologies, and also his teaching as professor of several generations of urologists, with the objective of trying to get to know his great human quality as he demonstrated over his life and showed in his writings. We review his books and works, lectures and published papers, in addition the news about his person we have collected from the media, and after analysis, mainly of his memories, we extract data reflecting his personality, and they way he thought and behaved. Since he was young he went with his father to the international urology meetings where he met a great number of personalities in the World of Urology; he extended his training with them, and later on they got to have a great relationship. He travelled around Europe and United States before and after Second World War, respectively, with stays in the most prestigious centers, which he described meticulously. He also reported his activity during the first two years he directed the Department of Urology at the Hospital La Princesa in Madrid and cited the series of collaborators he had. In his research works he made an ample description of historical development as introduction to the various pathologies he analyzed in depth. The reading of the narration of his trips, that he did in the convulse International time he lived, offers details which enable us to know firsthand the situation of urology and the human side of the actors he had relation with, and the social life they had, in addition to data about their families and daily life. As a researcher in transcendental chapters in urological pathology we emphasize his historical
Alvarez, Luis Walter (1911-88)
Murdin, P.
Physicist and astronomer, born in San Francisco, CA, professor at the University of California, Nobel prizewinner (1968) for his discoveries in particle physics. Used cosmic rays to `x-ray' the pyramids of Egypt, finding in particular that the tombs in the Great Pyramid at Giza had no hidden rooms. Alvarez (and his son) discovered globally distributed iridium at the Cretaceous/Tertiary boundary i...
Luis Alcoriza o la mexicanización del exiliado cinematográfico republicano = Luis Alcoriza or the Mexican Nationalization of the Republican Cinematography Exile
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Jorge Chaumel Fernández
Full Text Available Luis Alcoriza, exiliado republicano español en México, desarrolló su carrera como actor, guionista y director en su patria de adopción dándola algunas de sus mejores películas. En su condición de exiliado dispuso de mayor objetividad para mostrar los cambios de la sociedad mexicana y de sus principales problemas políticos. Figura imprescindible de la evolución del Cine Mexicano de la segunda mitad del siglo XX, se configura como uno de los principales ejemplos del fenómeno de mexicanización de los cineastas exiliados.Luis Alcoriza, Spanish republican exile in Mexico, developed his career as an actor, writer and director in his adopted country giving her some of his best films. In his exile he had before as objective to show the changes in Mexican society and its major political problems. Essential figure in the evolution of Mexican cinema in the second half of the twentieth century stands as one of the prime examples of the phenomenon of mexicanización of exiled filmmakers.
Sustainability Metrics: The San Luis Basin Project
Sustainability is about promoting humanly desirable dynamic regimes of the environment. Metrics: ecological footprint, net regional product, exergy, emergy, and Fisher Information. Adaptive management: (1) metrics assess problem, (2) specific problem identified, and (3) managemen...
75 FR 59285 - Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA
...] Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA AGENCY: U.S. Fish and... project in the community of Los Osos, San Luis Obispo County, California. We invite comments from the... community of Los Osos, San Luis Obispo County, California. The parcel is legally described as Assessor...
40 CFR 81.176 - San Luis Intrastate Air Quality Control Region.
... 40 Protection of Environment 17 2010-07-01 2010-07-01 false San Luis Intrastate Air Quality Control Region. 81.176 Section 81.176 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Quality Control Regions § 81.176 San Luis Intrastate Air Quality Control Region. The San Luis Intrastate...
76 FR 6517 - San Luis & Rio Grande Railroad-Petition for a Declaratory Order
... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35380] San Luis & Rio... petition filed by San Luis & Rio Grande Railroad (SLRG), the Board instituted a declaratory order... proposed operation of a truck-to-rail transload facility in Antonito, Colorado. See San Luis & Rio Grande R...
75 FR 8735 - Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA
...] Endangered and Threatened Wildlife and Plants; Permit, San Luis Obispo County, CA AGENCY: Fish and Wildlife... Luis Obispo County, California. We invite comments from the public on the application, which includes a... Luis Obispo County, California, that will meet Americans with Disabilities Act (ADA) accessibility...
Social Integration and Health Behavioral Change in San Luis, Honduras
McQuestion, Michael J.; Calle, Ana Quijano; Drasbek, Christopher; Harkins, Thomas; Sagastume, Lourdes J.
This study explores the effects of social integration on behavioral change in the course of an intensive, community-based public health intervention. The intervention trained volunteers and mobilized local organizations to promote 16 key family health practices in rural San Luis, Honduras, during 2004 to 2006. A mixed methods approach is used.…
Chasing Personal Meaning: Pedagogical Lessons through Luis Rodriguez's "Always Running"
Theisen-Homer, Victoria
In this autobiographical narrative, the author recounts her experiences teaching the novel "Always Running" by Luis Rodriguez with her English classes at a high school in a gang-heavy area. When she first started teaching, this teacher struggled to engage students. One particularly disruptive student requested to read "Always…
Geologic Map of the San Luis Quadrangle, Costilla County, Colorado
Machette, Michael N.; Thompson, Ren A.; Drenth, Benjamin J.
The map area includes San Luis and the primarily rural surrounding area. San Luis, the county seat of Costilla County, is the oldest surviving settlement in Colorado (1851). West of the town are San Pedro and San Luis mesas (basalt-covered tablelands), which are horsts with the San Luis fault zone to the east and the southern Sangre de Cristo fault zone to the west. The map also includes the Sanchez graben (part of the larger Culebra graben), a deep structural basin that lies between the San Luis fault zone (on the west) and the central Sangre de Cristo fault zone (on the east). The oldest rocks exposed in the map area are the Pliocene to upper Oligocene basin-fill sediments of the Santa Fe Group, and Pliocene Servilleta Basalt, a regional series of 3.7?4.8 Ma old flood basalts. Landslide deposits and colluvium that rest on sediments of the Santa Fe Group cover the steep margins of the mesas. Rare exposures of the sediment are comprised of siltstones, sandstones, and minor fluvial conglomerates. Most of the low ground surrounding the mesas and in the graben is covered by surficial deposits of Quaternary age. The alluvial deposits are subdivided into three Pleistocene-age units and three Holocene-age units. The oldest Pleistocene gravel (unit Qao) forms extensive coalesced alluvial fan and piedmont surfaces, the largest of which is known as the Costilla Plain. This surface extends west from San Pedro Mesa to the Rio Grande. The primary geologic hazards in the map area are from earthquakes, landslides, and localized flooding. There are three major fault zones in the area (as discussed above), and they all show evidence for late Pleistocene to possible Holocene movement. The landslides may have seismogenic origins; that is, they may be stimulated by strong ground shaking during large earthquakes. Machette and Thompson based this geologic map entirely on new mapping, whereas Drenth supplied geophysical data and interpretations.
Discovery of cryptophycin-1 and BCN-183577: examples of strategies and problems in the detection of antitumor activity in mice.
Corbett, T H; Valeriote, F A; Demchik, L; Lowichik, N; Polin, L; Panchapor, C; Pugh, S; White, K; Kushner, J; Rake, J; Wentland, M; Golakoti, T; Hetzel, C; Ogino, J; Patterson, G; Moore, R
Historically, many new anticancer agents were first detected in a prescreen; usually consisting of a molecular/biochemical target or a cellular cytotoxicity assay. The agent then progressed to in vivo evaluation against transplanted human or mouse tumors. If the investigator had a large drug supply and ample resources, multiple tests were possible, with variations in tumor models, tumor and drug routes, dose-decrements, dose-schedules, number of groups, etc. However, in most large programs involving several hundred in vivo tests yearly, resource limitations and drug supply limitations have usually dictated a single trial. Under such restrictive conditions, we have implemented a flexible in vivo testing protocol. With this strategy, the tumor model is dictated by in vitro cellular sensitivity; drug route by water solubility (with water soluble agents injected intravenously); dosage decrement by drug supply, dose-schedule by toxicities encountered, etc. In this flexible design, many treatment parameters can be changed during the course of treatment (e.g., dose and schedule). The discovery of two active agents are presented (Cryptophycin-1, and Thioxanthone BCN 183577). Both were discovered by the intravenous route of administration. Both would have been missed if they were tested intraperitoneally, the usual drug route used in discovery protocols. It is also likely that they would have been missed with an easy to execute fixed protocol design, even if injected i.v.
Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.
Martins da Silva, Sarah J; Brown, Sean G; Sutton, Keith; King, Louise V; Ruso, Halil; Gray, David W; Wyatt, Paul G; Kelly, Mark C; Barratt, Christopher L R; Hope, Anthony G
Can pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility? High-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor infertility. There is both huge demand and a genuine clinical need for new treatment options for infertile men. However, the time, effort and resources required for drug discovery are currently exorbitant, due to the unique challenges of the cellular, physical and functional properties of human spermatozoa and a lack of appropriate assay platform. Spermatozoa were obtained from healthy volunteer research donors and subfertile patients undergoing IVF/ICSI at a hospital-assisted reproductive techniques clinic between January 2012 and November 2016. A HTS assay was developed and validated using intracellular calcium ([Ca2+]i) as a surrogate for motility in human spermatozoa. Calcium fluorescence was detected using a Flexstation microplate reader (384-well platform) and compared with responses evoked by progesterone, a compound known to modify a number of biologically relevant behaviours in human spermatozoa. Hit compounds identified following single point drug screen (10 μM) of an ion channel-focussed library assembled by the University of Dundee Drug Discovery Unit were rescreened to ensure potency using standard 10 point half-logarithm concentration curves, and tested for purity and integrity using liquid chromatography and mass spectrometry. Hit compounds were grouped by structure activity relationships and five representative compounds then further investigated for direct effects on spermatozoa, using computer-assisted sperm assessment, sperm penetration assay and whole-cell patch clamping. Of the 3242 ion channel library ligands screened, 384 compounds (11.8%) elicited a statistically significant increase in calcium fluorescence, with greater than 3× median absolute deviation above the baseline. Seventy-four compounds eliciting ≥50% increase
El confesor regio Fray Luis Aliaga y la controversia Inmaculista
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Callado Estela, Emilio
Full Text Available The present article analyses the participation of the aragonese dominican monk Luis Aliaga (Zaragoza, 1565-† Zaragoza, 1626, last confessor of Philip III and Inquiring general of the Hispanic Monarchy from 1619, in one of the most white hot theological controversies along the 17th century: the Immaculate Conception of the Virgin MaryEl presente artículo analiza la participación del dominico aragonés fray Luis Aliaga (Zaragoza, 1565-† Zaragoza, 1626 , último confesor de Felipe III e Inquisidor general de la Monarquía Hispánica desde 1619, en una de las controversias teológicas más candentes a lo largo del siglo XVII: la Inmaculada Concepción de la Virgen María.
In memory of Luis Bernardo López
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Escuela de Estudios en Psicoanálisis y Cultura
Full Text Available In this issue of the magazine From the Garden of Freud we want to remember what the presence of Luis Bernardo López meant in the spirit of this publication. The design and the initial model were the work of Santiago Mutis, as well as the idea of inviting a plastic artist for each number and the care of the graphic part for that exercise. However, Luis Bernardo also participated in his conception, and in his birth, in 2001, since it was his first director and editor, work that continued the following year to later take back the address of the number 7 and to advance the graphic edition of the Numbers 8 to 13. In this work I knew how to give the best shape to the project of a serial publication with which we dreamed since the year 2000.
Exposiciones: Capuleto en la sala "Luis Ángel Arango"
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Arístides Meneghetti
Full Text Available La exposición del joven pintor español Francisco Capuleto, realizada en la Biblioteca "Luis Ángel Arango" el pasado mes de mayo, refresca un viejo problema en la conciencia de todo americano. Existen dos Españas diferentes, la una folclórica, de aire flamenco, majas y alegres panderetas, creada para la exportación y el turismo, a que son tan afectas las personas.
Topology Discovery Using Cisco Discovery Protocol
Rodriguez, Sergio R.
In this paper we address the problem of discovering network topology in proprietary networks. Namely, we investigate topology discovery in Cisco-based networks. Cisco devices run Cisco Discovery Protocol (CDP) which holds information about these devices. We first compare properties of topologies that can be obtained from networks deploying CDP versus Spanning Tree Protocol (STP) and Management Information Base (MIB) Forwarding Database (FDB). Then we describe a method of discovering topology ...
Geothermal resource assessment of western San Luis Valley, Colorado
Energy Technology Data Exchange (ETDEWEB)
Zacharakis, Ted G.; Pearl, Richard Howard; Ringrose, Charles D.
The Colorado Geological Survey initiated and carried out a fully integrated assessment program of the geothermal resource potential of the western San Luis Valley during 1979 and 1980. The San Luis Valley is a large intermontane basin located in southcentral Colorado. While thermal springs and wells are found throughout the Valley, the only thermal waters found along the western part of the Valley are found at Shaw Warm Springs which is a relatively unused spring located approximately 6 miles (9.66 km) north of Del Norte, Colorado. The waters at Shaws Warm Spring have a temperature of 86 F (30 C), a discharge of 40 gallons per minute and contain approximately 408 mg/l of total dissolved solids. The assessment program carried out din the western San Luis Valley consisted of: soil mercury geochemical surveys; geothermal gradient drilling; and dipole-dipole electrical resistivity traverses, Schlumberger soundings, Audio-magnetotelluric surveys, telluric surveys, and time-domain electro-magnetic soundings and seismic surveys. Shaw Warm Springs appears to be the only source of thermal waters along the western side of the Valley. From the various investigations conducted the springs appear to be fault controlled and is very limited in extent. Based on best evidence presently available estimates are presented on the size and extent of Shaw Warm Springs thermal system. It is estimated that this could have an areal extent of 0.63 sq. miles (1.62 sq. km) and contain 0.0148 Q's of heat energy.
Fé antropológica como ponte entre fé e ideología em Juan Luis Segundo
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Alvori Ahlert
Full Text Available Este texto busca a compreensão da ideología em sua relação com a fé na teologia latinoamericana a partir da concepção de fé antropológica na obra de Juan Luis Segundo. Acreditamos que a questão da ideología, e sua relação com a fé, continua sendo urna questão atual no pensamento cristão, face aos velhos e novos problemas humanos que o novo sáculo vem apresentando. Concentramos nossa análise nos escritos de Juan Luis Segundo, um dos principáis representantes dessa teologia, por ser este teólogo que, ao nosso ver, mais trabalhou, de forma explícita, a questão da ideología e sua relação com a fé no contexto latinoamericanoThis text searchs the understanding of the ideology in its relation with the faith in the Latin American theology from the conception of antropology faith in the workmanship of Juan Luis Segundo. We believe that the question of the ideology, and its relation with the faith, continue being a current question in the Christian thought, face to the old and new human problems that the new century comes presenting. We concentrate our analysis on the writings of Juan Luis Segundo, one of the main representatives of this theology, for being this theologian who, to ours to see, more worked, of explicit form, the question of the ideology and its relation with the faith in the Latin American context
Emma Zunz by Jorge Luis Borges: the Concept of Justice
Rosa Vila
Emma Zunz, by Jorge Luis Borges, is the story of a girl who decides to kill her boss in order to avenge her father's death, believing that her father's version of an event that occurred years before was true. Thus, she devises a secret plan, which includes losing her virginity to a complete stranger, shortly before committing the crime, so she could argue that her boss had raped her and that she killed him in self-defense. Firstly, the text shows the contrast between formal justic...
Puelles romero, Luis: Honoré Daumier: la risa republicana
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Óscar Ortega Ruiz
Full Text Available Recientemente, Abada Editores ha puesto a disposición de sus lectores el nuevo ensayo de Luis Puelles Romero, titular de Estética y Teoría de las Artes de la Universidad de Málaga. Honoré Daumier: la risa republicana se interna en la vida y la obra de este marsellés nacido en 1808 y muerto en París en 1879, cuyo trabajo se desarrolló durante cincuenta años decisivos de la historia de Francia, desde el final del periodo legitimista hasta los inicios de la III República.
Eric Bach : ilustrador de Luis de Góngora
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María Dolores Antigüedad del Castillo Olivares
Full Text Available El pintor holandés Eric Bach [Eríurt (Alemania 1911] ha mostrado durante el año 1991 sus obras como ilustrador en sendas exposiciones celebradas en Córdoba y Madrid. El artista que reside indistintamente en Munich y Barcelona, expuso las ilustraciones que ha realizado para la edición en alemán de Los veinticuatro sonetos amorosos, heroicos y fúnebres de don Luis de Góngora, edición hecha por encargo del Sr. Rüdiger Kampmann de Munich.
DEFF Research Database (Denmark)
Dias, Gustavo Fruet; Scherrer, Cristina; Papailias, Fotis
The price discovery literature investigates how homogenous securities traded on different markets incorporate information into prices. We take this literature one step further and investigate how these markets contribute to stochastic volatility (volatility discovery). We formally show...... that the realized measures from homogenous securities share a fractional stochastic trend, which is a combination of the price and volatility discovery measures. Furthermore, we show that volatility discovery is associated with the way that market participants process information arrival (market sensitivity......). Finally, we compute volatility discovery for 30 actively traded stocks in the U.S. and report that Nyse and Arca dominate Nasdaq....
75 FR 76726 - San Luis Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...
... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2196-000] San Luis Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of San Luis [[Page 76727
Art as Critical Public Pedagogy: A Qualitative Study of Luis Camnitzer and His Conceptual Art
Zorrilla, Ana; Tisdell, Elizabeth J.
This qualitative study explored the connection between art and adult education for critical consciousness from the perspective and work of conceptual artist, Luis Camnitzer. The theoretical framework is grounded in the critical public pedagogy literature. Data collection methods included interviews with conceptual artist Luis Camnitzer and with…
Ontwikkeling en demonstratie van een geintegreerd bestrijdingssysteem voor de rode luis Myzus nicotianae
Dijken, van M.J.
De geïntegreerde plaagbestrijding van de paprikateelt onder glas, wordt sinds 1993 verstoord door de opkomst van de rode luis, Myzus nicotianae. Deze luis is namelijk resistent tegen het selectieve chemische correctiemiddel pirimicarb en een effectieve biologische bestrijding was onvoldoende
Los avisos para la muerte de Luis Ramirez de Arellano
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Inmaculada Osuna
Full Text Available Avisos para la muerte (1634, compiled by Luis Ramírez de Arellano, gathers, along with other complementary materials (among these, two prayers written in verse for before confession and before communion, and an act of contrition in prose, thirty poems that are presented as models for prayers addressed to a crucified Christ in the moment of his death. These poems emerge from a group initiative in which notable poets from the Madrid court took part, poets such as Lope de Vega, Pedro Calderón de la Barca, José de Pellicer, José de Valdivielso, Luis Vélez de Guevara, Juan Pérez de Montalbán and Francisco de Rojas Zorrilla. My article examines the social context in which this poetic collection is born, the composition of the book, its successful publishing history throughout two centuries as well as the reiterative representation in the poems of particular meditatio mortis topics (the staging of agony; the expression of repentance, love for Christ and hope for his mercy; and the contemplation of Christ's body on the cross.
76 FR 41811 - Kellaway Proposed Low-Effect Habitat Conservation Plan for the Morro Shoulderband Snail, San Luis...
...] Kellaway Proposed Low-Effect Habitat Conservation Plan for the Morro Shoulderband Snail, San Luis Obispo... species in the community of Los Osos, San Luis Obispo County, California. The applicants would implement a... Los Osos, San Luis Obispo County, California. The applicants are requesting a permit for take of Morro...
75 FR 17430 - Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Kern, San Luis Obispo...
...] Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Kern, San Luis Obispo, Tulare... Wildlife Refuges (NWRs) located in Kern, San Luis Obispo, Tulare, and Ventura counties of California. We... developing a CCP for Hopper Mountain, Bitter Creek, and Blue Ridge NWRs in Kern, San Luis Obispo, Tulare, and...
78 FR 73557 - Guadalupe-Nipomo Dunes National Wildlife Refuge, San Luis Obispo County, CA: Intent To Prepare a...
...-FF08R00000] Guadalupe-Nipomo Dunes National Wildlife Refuge, San Luis Obispo County, CA: Intent To Prepare a...) for the Guadalupe-Nipomo Dunes National Wildlife Refuge located in San Luis Obispo County of... (Refuge) in San Luis Obispo County, California. This notice complies with our CCP policy to (1) advise...
DEFF Research Database (Denmark)
Korsgaard, Steffen; Sassmannshausen, Sean Patrick
In this chapter we explore four alternatives to the dominant discovery view of entrepreneurship; the development view, the construction view, the evolutionary view, and the Neo-Austrian view. We outline the main critique points of the discovery presented in these four alternatives, as well...
Brown, Herbert C.
The role of discovery in the advance of the science of chemistry and the factors that are currently operating to handicap that function are considered. Examples are drawn from the author's work with boranes. The thesis that exploratory research and discovery should be encouraged is stressed. (DT)
José Luis Hidalgo, poeta de los muertos
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Román GARCÍA-CAMINO MATEOS
Full Text Available RESUMEN: La figura de José Luis Hidalgo (Torres, 1919-Madrid, 1947, poeta y pintor, ha de tomar un nuevo relieve como representante de una generación de autores montañeses que surgió en torno a los años cuarenta. Destaca en su breve obra, al igual que su corta pero intensa vida, la extrema sensibilidad de su poesía en el uso de imágenes, metáforas que acercan sus versos hacia el terreno de lo plástico y sensorial. Las preocupaciones son de profunda raigambre existencialista, al ser nuestro poeta un joven lector de pensadores como Nietzsche, Schopenhauer o Unamuno; es con este último con el que guarda una ineludible afinidad de ideas. La búsqueda que emprende José Luis Hidalgo hacia la verdad se sitúa dentro de una metafísica trascendente y una vertiente religiosa muy significativa, en un diálogo sincero y directo con Dios. Contrasta la sencillez formal de su poesía con el complejo sistema simbólico de elementos naturales, espacios... en los que se mueve dentro del marco fluctuante entre la tradición y la vanguardia; encontramos resonancias que nos llevan desde el romanticismo becqueriano, pasando por el simbolismo, hasta los movimientos vanguardistas —sobre todo el surrealismo— y el grupo poético del 27. La obra de Los muertos supone un momento culmen del dilatado periodo de posguerra.ABSTRACT: The literary figure of José Luis Hidalgo (Torres, 1919-Madrid, 1947, both a poet and a painter, achieves renown once more as a representative of a generation of writers from Cantabria (in the north of Spain which came to light around the 1940's. His work, as brief as his short but intense life, is remarkable for the great feeling of his poetry in the use of imagery and metaphors, which draw his verse near the domain of the vivid and sensorial. His concerns have deep existentialist roots; as a young man the poet was a devoted reader of great thinkers such as Nietzsche, Schopenhauer or Unamuno; it is the latter with whom he has an
Luis Llach : el arquitecto de Quibdó
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Luis Fernando González Escobar
Full Text Available En el año 1907, en varias ediciones del periódico Ecos del Chocó, de la ciudad de Quibdó, apareció un anuncio en donde un tal Luis Llach Ll., ostentando el título de ingeniero civil, ofertaba sus servicios para la "Construcción de toda clase de edificios, Levantamientos de planos. elaboración de presupuestos, etc. y toda lo concerniente al ramo de ingeniería, contando para el efecto con instrumentos modernos y personal idóneo" ¿La dirección? El lado sur del Convento. ¿Quién era este "ingeniero" y cuáles eran las razones que lo condujeron a establecerse en una localidad que por esos años no era más que un villorrio con algo menos de 12.000 habitantes?
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Victor Sánchez Montenegro
Full Text Available Es una creencia general difundida por muchas historias de la literatura española y universal de que la principal causa de la prisión de Fray Luis de León en Valladolid por la Inquisición de esa ciudad, fue el haber traducido el Cantar de los Cantares, atribuidoa Salomón , es decir el Sir hassirim que los LXX tradujeron al griego Aisma Aismaton, y el Cantica Canticorum de la Vulgata. Sin embargo, como pasaré a demostrar, no fue esa precisamente la causa de la tremenda injusticia sino otras presentarlas por sus enemigos , quienes en sus ataques hasta llegaron a probar que no descendía de Cristianos viejos sino que tenía sangre de judíos.
Luis Huerta: Eugenics, Medicine and Pedagogy in Spain
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Luis Miguel LÁZARO LORENTE
Full Text Available By comparison with the historiography of other European and Anglo-Saxon countries, the study of the origins and spread of Eugenics in Spain has not received much attention. Even less research has been done on the degree of acceptance of eugenic thought in the pedagogical domain or on the role teachers may have in the diffusion of eugenics. This paper attempts to explore the subject while focusing the analysis on the relations that were established among Medicine, Pedagogy and Eugenics in Spain during the first third of the 20th century. We will take as a point of reference and guiding line of thought the figure of the Asturian teacher Luis Huerta Naves, who was the driving force and tireless advocate of the eugenics movement in our country.
Luis Patiño Camargo Maestro, Investigador, Humanista
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José Felix Patiño Restrepo
Full Text Available
Palabras del doctor José Félix Patiño Restrepo, Académico de Número, con motivo de la Sesión Solemne de la Academia Nacional de Medicina para conmemorar el centenario del natalicio del Profesor Luis Patiño Camargo.
Santafé de Bogotá, noviembre 21 de 1991
Son varias las semblanzas que distinguidas personalidades de Colombia y del exterior han escrito sobre el Profesor Luis Patiño Camargo, cuya vida ejemplar dejó honda huella en la medicina y la ciencia colombianas: Carlos Lleras Restrepo y Juan Lozano y Lozano en 1978; Augusto Gast Galvis, Fernando Serpa Flórez y Alfonso Jaram illo Salazar en 1979; Eduardo Guzmán Esponda, Remando Groot y José Francisco Socarrás en 1981; Amador Neghme, de Chile en 1987; Ernesto Andradc Valderrama en 1988, y ahora Carlos Sanmartín Barberi.
"Bella vida y bella muerte la de Luis Patiño Camargo, pensaba yo cuando iba caminando detrás del féretro, después de los sencillos oficios en la iglesia de Iza, hacia el cementerio campesino donde él dispuso que se enterrara en medio de las tumbas de sus padres y debajo de los pinos que plantó con su propia mano". Así inició Carlos Lleras Restrepo un sentido artículo sobre Patiño Camargo publicado en la Nueva Frontera a los pocos días de su muerte, acaecida en Sogamoso el 13 de noviembre de 1978. Porque ese fue su deseo: reposar para siempre en el cementerio que domina su bello pueblo andino, Iza, donde había nacido el 24 de noviembre de 1891.
Dijo Gast Galvis: "El Dr. Patiño, como el cacique de Inza, después de mucho peregrinar por todo el territorio colombiano, encontró un lugar de brisas tibias, cielo siempre azul, abundantes aguas, suelo fértil, en donde se pudiera vivir y morir en paz".
Científico, maestro, médico, naturalista, filósofo, humanista, todo eso fue Luis Patiño Camargo, y ninguno de estos términos lo caracteriza de por sí, sino más bien el conjunto de ellos
The cinephilic citation in the essay films by José Luis Guerin and Isaki Lacuesta
Vidal, Belén
This paper investigates the contemporary turn to cinephilia as an object of theoretical analysis and historiographical investigation through the essay films by José Luis Guerin and Isaki Lacuesta. In particular, I focus on Innisfree (José Luis Guerin 1990), Tren de sombras (Train of Shadows, José Luis Guerin 1997), Las variaciones Marker (The Marker Variations, Isaki Lacuesta 2008) and La noche que no acaba (All the Night Long, Isaki Lacuesta 2010). This work recovers and restages "cinephilic...
Magnetotelluric data collected to characterize aquifers in the San Luis Basin, New Mexico
Ailes, Chad E.; Rodriguez, Brian D.
The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic Framework of Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, magnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers in the San Luis Basin. This report describes one north-south and two east-west regional magnetotelluric sounding profiles, acquired in June of 2010 and July and August of 2011, across the San Luis Basin in northern New Mexico. No interpretation of the data is included.
Upper Holocene in a profile:tectonic depression of Conlara-Sierra de San Luis, San Luis, Argentina
International Nuclear Information System (INIS)
Strasser, E.; Chiesa, J.
The characteristics of three column profiles belonging to eolic sediments, assignated to Upper Holocene of the Depression of Conlara and oriental edge of San Luis range, comprising loessic materials and sandy loessoides, associated to aluvio-eolic and pedogenetic levels are texturally described. Lineal graphics of expression are used to visualize the textual variations according to the deph, those graphics are built according to the curve of frequency accumulated of the distribution of the size, using the parameters of rank in phi (Q) intervals and the half diameter expressed in microns. The interpretation of the succession in ecuatorial direction allows the inferences of the decrease of the size of grain from the planicie (on the east) towards the mountain region (on the west). The values of parameters of rank and statistiral parameters are presented, of all the succession although it is proposed that the Upper Holocene corresponds to the two upper meters [es
Representation Discovery using Harmonic Analysis
Mahadevan, Sridhar
Representations are at the heart of artificial intelligence (AI). This book is devoted to the problem of representation discovery: how can an intelligent system construct representations from its experience? Representation discovery re-parameterizes the state space - prior to the application of information retrieval, machine learning, or optimization techniques - facilitating later inference processes by constructing new task-specific bases adapted to the state space geometry. This book presents a general approach to representation discovery using the framework of harmonic analysis, in particu
DEFF Research Database (Denmark)
Sannino, Francesco
has been challenged by the discovery of a not-so-heavy Higgs-like state. I will therefore review the recent discovery \\cite{Foadi:2012bb} that the standard model top-induced radiative corrections naturally reduce the intrinsic non-perturbative mass of the composite Higgs state towards the desired...... via first principle lattice simulations with encouraging results. The new findings show that the recent naive claims made about new strong dynamics at the electroweak scale being disfavoured by the discovery of a not-so-heavy composite Higgs are unwarranted. I will then introduce the more speculative......I discuss the impact of the discovery of a Higgs-like state on composite dynamics starting by critically examining the reasons in favour of either an elementary or composite nature of this state. Accepting the standard model interpretation I re-address the standard model vacuum stability within...
Exposiciones 1958, presentadas en la Biblioteca Luis Ángel Arango
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Boletín Cultural y Bibliográfico Banco de la República
Full Text Available Se describe el desarrollo de la actividades culturales del año 1958 correspondientes a las exposiciones de arte presentadas en la Biblioteca Luis Ángel Arango del Banco de la República.
The San Luis Project: An Attempt to Decentralize Physics in Mexico
Will, T. A.; Valladares, A. A.
Described is a project being conducted by the Physics Institute of the University of San Luis Potori, Mexico, in order to avoid concentrating physics education and research activities in Mexico City. (SL)
En el día del bibliotecario: Homenaje al Doctor Luis Ángel Arango
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Ernesto Delgado
Full Text Available Palabras pronunciadas por el presidente de la Asociación Colombiana de Bibliotecarios, señor Ernesto Delgado, en el Salón de Actos de la Biblioteca Luis Ángel Arango, el sábado 28 de abril, Día del Bibliotecario, con motivo del homenaje que dicha corporación rindió a la memoria del doctor Luis Ángel Arango.
Emma Zunz by Jorge Luis Borges: the Concept of Justice
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Rosa Vila
Full Text Available Emma Zunz, by Jorge Luis Borges, is the story of a girl who decides to kill her boss in order to avenge her father's death, believing that her father's version of an event that occurred years before was true. Thus, she devises a secret plan, which includes losing her virginity to a complete stranger, shortly before committing the crime, so she could argue that her boss had raped her and that she killed him in self-defense. Firstly, the text shows the contrast between formal justice and taking justice into own hands. Secondly, the question of self-inflicted punishment, which in the story takes place before the perpetration of the crime. Finally, the issue whether truth is the version that can be inferred from the evidence presented in a trial, or the one which is kept to themselves by those involved in a crime. Emma Zunz, de Jorge Luis Borges, es la historia de una chica que decide matar a su jefe para vengar la muerte de su padre, creyendo que la versión de su padre de un hecho que ocurrió años atrás era cierta. De este modo, diseña un plan secreto, que incluye la pérdida de su virginidad con un desconocido, poco antes de cometer el crimen, para poder argumentar que su jefe la había violado y que ella lo mató en defensa propia. En primer lugar, el texto muestra el contraste entre la justicia formal y la justicia por cuenta propia. En segundo lugar, la cuestión de la pena infligida a uno mismo, lo que en la historia se produce antes de la comisión del delito. Por último, la cuestión de si la verdad es la versión que se puede inferir de las pruebas presentadas en un juicio, o la que se guardan para sí mismas las personas involucradas en un crimen. DOWNLOAD THIS PAPER FROM SSRN: http://ssrn.com/abstract=2519490
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Svetlana COANDĂ
Full Text Available În articol sunt evidenţiate etapele evoluţiei spirituale a lui Lucian Blaga, este demonstrată importanţa primei perioade de activitate a gânditorului român, perioada anilor 1914-1919, care constituie începutul activităţii filosofice a lui L.Blaga, acesta fiind deosebit de semnificativ pentru înţelegerea genezei ideilor sale, a influenţelor pe care le-a suportat, a continuităţii tematicii şi reflecţiilor filosofice, care au culminat cu elaborarea unui profund sistem filosofic. Sunt analizate în detaliu ideile filosofice centrale, temele de meditaţie din lucrările scrise şi publicate de L.Blaga între anii 1914 şi 1919: analiza şi aprecierea ideilor filosofului francez Henri Bergson, coraportul dintre filosofie şi ştiinţă, aportul specific al filosofiei la formarea concepţiei despre lume a personalităţii, rolul deosebit de important al metodelor de cercetare în asigurarea obţinerii adevărului în procesul de cunoaştere, unitatea formelor culturii etc.THE PHILOSOFICAL BEGINNINGS OF LUCIAN BLAGAThis article highlights the spiritual evolution steps of Lucian Blaga and demonstrates the importance of the first period of activity of the Romanian thinker - the period between 1914 and 1919. This time frame constitutes the beginning of his philosophical activity and it is especially significant to understand the genesis of his ideas, of his influences, the continuity of the philosophical themes and reflections that culminated with the elaboration of a profound philosophical system. Analysis is done over the central philosophical ideas, the meditation themes from the works written and published by Lucian Blaga between 1914 and 1919: the analysis and appreciation of the ideas of the French philosopher Henri Bergson, the correlation between philosophy and science, the specific input of philosophy in the formation of the world conception on personality, the extremely important role of the research methods in ensuring the
Luis Fayad. Dalla narrativa urbana agli innesti socioculturali. Presentazione
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Martha L. Canfield
Full Text Available The article looks at Luis Fayad's novel La caída de los puntos cardinales (2000 in order to foreground the influence of Arabic on the Colom- bian author whose grandparents were Lebanese. Born in Bogotá in 1945, Fayad published the novel after being identified as one of the first Colombian novelists dealing with urban literature. It represents a change of direction in his career, as Fayad narrates the entire life of six main characters, four men and two women, who decide to leave Lebanon and migrate to South America, ending up in Colombia. The analysis will focus on the importance of the circulation of the book in Italy by virtue of issues of intercultural exchange embedded in the novel. La caída de los puntos cardinales mixes Arabic tradition and Colombian customs; in the novel, Fayad achieves a cross-cultural story that may provide a successful model of integration. The Spanish-Italian translation and a critical approach to the language used by the novelist and employed by the translator will complete the essay.
Luis G. Urbina: crônicas porfirianas
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Miguel Angel Castro
Full Text Available As descrições amenas de uma cidade instável, às vezes divertida e atrativa, outras, entediante e miserável, assim como a crítica de costumes de seus habitantes, abrem um espaço original à tolerância e nele se fundamenta a natureza democrática da crônica jornalística do último quarto do século XIX e se determina o prolongamento de alguns dos seus traços literários no início do século XX. Com o intuito de conservar o valor literário de origem se constrói uma poética do gênero. Neste artigo, apresentamos algumas observações feitas a esse respeito nas crônicas que Luis G. Urbina publicou em El Mundo ilustrado entre 1899 e 1906. This work is licensed under a Creative Commons Attribution 3.0 License.
Optical spectroscopy and luminescence quenching of LuI3:Ce3+
International Nuclear Information System (INIS)
Birowosuto, M.D.; Dorenbos, P.; Haas, J.T.M. de; Eijk, C.W.E. van; Kraemer, K.W.; Guedel, H.U.
Optical spectroscopy of LuI 3 doped with Ce 3+ using ultraviolet and visible light excitation is reported. LuI 3 host excitation and emission and 4f-5d excitation and emission of Ce 3+ are observed. An empirical model based on crystal field splitting was used to estimate the energy of the highest 4f-5d excitation band. The crystal field splitting and centroid shift were compared to those of LuCl 3 :Ce 3+ and LuBr 3 :Ce 3+ . Temperature dependence of X-ray excited luminescence spectra shows thermal quenching, whereas that of the decay curve of Ce 3+ emission excited at the lowest 5d band of Ce 3+ does not indicate the presence of quenching of Ce 3+ emission for temperature below 625K. The quenching in LuI 3 :Ce 3+ therefore occurs before the 5d Ce 3+ emission takes place
Magmatism and mineralization ages from northeast area of La Sierra de San Luis, Argentina
International Nuclear Information System (INIS)
Ulacco, Jose H
Three igneous rock groups, characterized as pre, sin and post-kinematics, have intruded the crystalline basement of Sierra de San Luis, Argentina. The ore deposits are associated with Devonian to Carboniferous epizonal granite stocks and batholiths in an area underlain by metamorphic rocks. This granitoids are characterized as post-kinematics magmatism. Model lead ages on the ore deposits (338,8 - 292,1 Ma) are strongly supported by K-Ar ages of the intrusives. The bulk of the north Sierra de San Luis ore deposits are genetically related to late Carboniferous granite plutons. The ore bodies are tungsten veins with greisen envelopes, lead veins, epithermal fluorite veins and REE and Th deposit. A generalized scheme of ore bodies related to granites is proposed. The ore deposits and their lithotectonic setting are characteristic of Gondwana metallogenetic Epoch in the Sierra de San Luis (au)
Water Supply: Management of Water Sources in the City of San Luis Potosí (México, 1831-1887
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Yuritzi Hernández Fuentes
Full Text Available This paper proposes an approach about the management of water sources, hydraulic systems and the measures taken by the city government of San Luis Potosí (México concerning the need of water supply during the years 1831 to 1886. This paper examines two important projects on water management in the city: the aqueduct of La Cañada del Lobo and the policies taken by the authorities on waterways through La Corriente. Both projects faced several problems, including the outbreak of illnesses associated with bodies of water and shortage of liquid flow through the aqueduct of La Cañada del Lobo.
Entre la escasez y la inundación. Manejo del agua en la ciudad de San Luis Potosí, 1776-1888.
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Yuritzi Hernández Fuentes
Full Text Available This paper studies the historic connection between the hydric resources of the city of San Luis Potosí and their population during the XIX century, in special the management residual water and pluvial, and describing the demand for agricultural use, sanitation conflicts, systems of canalization failed to serve to water needs and also the population vulnerability to the floods. All this was result of the transformation of the system hydric of the catchment area and society actions to water use and this originated problems with water scarcity and floods that existed years before.
76 FR 33362 - Request for Interest in Lease Arrangement on Federal Lands, San Luis Project, Los Banos, California
... facilitating environmentally appropriate renewable-energy projects involving solar, wind and waves, geothermal... Federal Lands, San Luis Project, Los Banos, California AGENCY: Bureau of Reclamation, Interior. ACTION... energy project(s) in a lease arrangement on existing Reclamation lands in the vicinity of the San Luis...
77 FR 21797 - Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Ventura, Kern, San Luis...
... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R8-R-2011-N253: FXRS12650800000S3-112-FF08R00000] Hopper Mountain, Bitter Creek, and Blue Ridge National Wildlife Refuges, Ventura, Kern, San Luis... acres, primarily in Kern County and extending into San Luis Obispo and Ventura Counties. Blue Ridge NWR...
78 FR 16569 - Iowa Pacific Holdings, LLC, Permian Basin Railways, and San Luis & Rio Grande Railroad-Corporate...
... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35721] Iowa Pacific Holdings, LLC, Permian Basin Railways, and San Luis & Rio Grande Railroad--Corporate Family Transaction... subsidiaries Permian Basin Railways (PBR) and San Luis & Rio Grande Railroad (SLRG), and Massachusetts Coastal...
76 FR 45602 - Proposed Safe Harbor Agreement for California Red-Legged Frog, at Swallow Creek Ranch, San Luis...
... DEPARTMENT OF THE INTERIOR Fish and Wildlife Service [FWS-R8-ES-2011-N144; 81440-1113-0000-F3] Proposed Safe Harbor Agreement for California Red-Legged Frog, at Swallow Creek Ranch, San Luis Obispo... Ranch in San Luis Obispo County, California. Within the 620 acres of land comprising the Enrolled...
76 FR 31678 - San Luis & Rio Grande Railroad-Continuance in Control Exemption-Saratoga and North Creek Railway...
... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35499] San Luis & Rio Grande Railroad--Continuance in Control Exemption--Saratoga and North Creek Railway, LLC San Luis & Rio Grande Railroad (SLRG), a Class III rail carrier, has filed a verified notice of exemption to continue in...
Future Drinking Water Supply, Spatial Analysis and Vulnerability of the City of San Luis Potosi, Mexico
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Carlos Contreras Servín
Full Text Available This paper discusses and presents the physical, social and economic circumstances that affect the overall picture and the current issues that involve the drinking water supply for the metropolitan area of San Luis Potosi. The relationship between water availability and increasing population, as well as the evolution of the groundwater extraction, are among the topics addressed here. Additionally, this research shows a diagnosis of the current situation of the drinking water supply in San Luis Potosi and the surrounding areas, as well as the likely scenario in the near future.
Marxismo y Moral. Reflexiones a partir de El marxismo como moral de José Luis López Aranguren
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Muñoz, Jacobo
Full Text Available Starting from a critical reading of El marxismo como moral, classical work of José Luis López Aranguren, this article deals with the problem of the normative and moral foundations of marxism. In order to go in depth into the ethical dimension of Karl Marx's and the marxist tradition's thought, the text proposes several thematic lines of analysis with the aim of liberating, at the same time, the intelectual and political project of Marx from the various clichés associated to its traditional reception. The ethical field will appear as a space of mediation between knowledge and reality, disclosing itself as fundamental to marxism from a praxeological point of view. At the end of the article there is a critical dialogue with different ethical positions in the frame of contemporary marxism.A partir de una lectura crítica de El marxismo como moral, obra clásica de José Luis López Aranguren, éste artículo trata de interrogarse acerca de los fundamentos normativos y morales del marxismo. A lo largo del texto se proponen diversas líneas temáticas para profundizar en la dimensión ética del pensamiento de Karl Marx y la tradición marxista, tratando de liberar, al mismo tiempo, su proyecto intelectual y político de diversos tópicos vinculados a su recepción tradicional. El ámbito ético aparecerá como espacio de mediación entre el conocimiento y la realidad, revelándose como fundamental para el marxismo desde un punto de vista praxeológico. Al final del artículo se dialoga críticamente con algunas posiciones éticas en el marco del marxismo contemporáneo.
Many people don't realise quite how much is going on at CERN. Would you like to gain first-hand knowledge of CERN's scientific and technological activities and their many applications? Try out some experiments for yourself, or pick the brains of the people in charge? If so, then the «Lundis Découverte» or Discovery Mondays, will be right up your street. Starting on May 5th, on every first Monday of the month you will be introduced to a different facet of the Laboratory. CERN staff, non-scientists, and members of the general public, everyone is welcome. So tell your friends and neighbours and make sure you don't miss this opportunity to satisfy your curiosity and enjoy yourself at the same time. You won't have to listen to a lecture, as the idea is to have open exchange with the expert in question and for each subject to be illustrated with experiments and demonstrations. There's no need to book, as Microcosm, CERN's interactive museum, will be open non-stop from 7.30 p.m. to 9 p.m. On the first Discovery M...
"Time for Some Traffic Problems": Enhancing E-Discovery and Big Data Processing Tools with Linguistic Methods for Deception Detection
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Erin Smith Crabb
Full Text Available Linguistic deception theory provides methods to discover potentially deceptive texts to make them accessible to clerical review. This paper proposes the integration of these linguistic methods with traditional e-discovery techniques to identify deceptive texts within a given author's larger body of written work, such as their sent email box. First, a set of linguistic features associated with deception are identified and a prototype classifier is constructed to analyze texts and describe the features' distributions, while avoiding topic-specific features to improve recall of relevant documents. The tool is then applied to a portion of the Enron Email Dataset to illustrate how these strategies identify records, providing an example of its advantages and capability to stratify the large data set at hand.
Missionary Pragmalinguistics: Father Diego Luis de Sanvitores' grammar within the tradition of Philippine grammars
Winkler, A.P.
The grammar written in Latin, in 1668, by the Jesuit missionary Father Diego Luis de Sanvitores (1627-1672) is the oldest description we have of Chamorro, a language spoken on the Mariana islands. The grammar received a number of bad reviews and as a consequence has become neglected and almost
Origen, protagonistas y alianzas. El Banco de San Luis Potosí, 1897-1916
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Moisés Gámez Rodriguez
Full Text Available En este trabajo se expone el origen de la banca en San Luis Potosí, cuyo estudio se centra a partir de la legislación bancaria de 1897, que representa históricamente la institucionalización y modernización de la empresa bancaria mexicana. Como punto de partida se plantea que los perfiles financieros y empresariales de los involucrados en el nacimiento del Banco de San Luis Potosí, y representados en los miembros de su Consejo de Administración, son importantes para entender la configuración del sistema, y también que las redes extendidas en torno a dicha empresa muestran prácticas financieras de la economía de México en el último cuarto del siglo XIX. _________________________ This article explains the origin of banking in San Luis Potosi from the legislation in 1897, which historically represents the institutionalization and modernization of Mexican banking companies. As a starting point, it argues that financial and business profiles of those involved in the birth of Bank of San Luis Potosi and represented in the Board of Directors are important to understand the system configuration. Furthermore, the networks extended around the banking company show financial practices of Mexican economy in the last quarter of the 19th century.
The nuclear industry is about to begin a new dynamic. Interview with Luis Echavarri
Energy Technology Data Exchange (ETDEWEB)
Mitev, Lubomir [NucNet, Brussels (Belgium)
The nuclear industry has changed significantly in the 17 years since Luis Echavarri became director-general of the Organisation for Economic Development and Cooperation's (OECD) Paris-based Nuclear Energy Agency (NEA). As he approaches retirement, Mr Echavarri speaks to NucNet about the priorities for the industry as it enters the post-Fukushima era. (orig.)
De la BLAA: Exposición en la Biblioteca Luis Angel Arango
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Juan Camilo Sierra
Full Text Available Hasta febrero de 2003 la Biblioteca Luis Ángel Arango exhibirá una de las muestras más representativas del arte religioso internacional: 500 años de arte ruso. Iconos de la Galería Tretyakof de Moscú. Publicamos algunos apartes del plegable que acompaña la muestra.
Mesquite: A multi-purpose species in two locations of San Luis Potosi, Mexico
Jose Villanueva-Diaz; Augustin Hernandez-Reyna; J. Armando Ramirez-Garcia
The mesquite woodland distributed in approximately 200,000 ha in Llanos de Angostura, and Pozo del Carmen, San Luis Potosi, represents a main source of firewood, construction material, honey, and forage for the rural people that inhabit part of the lowlands of the hydrological region RH26 and RH37. Firewood collection in this region averages 142 m3 /week. Most of this...
Uranium occurrences in the pegmatite 'Las Cuevas', province of San Luis, Argentine Republic
International Nuclear Information System (INIS)
Daziano, C.O.; Karlsson, A.C.; Ayala, R.
Mineral associations found in an uranium deposit of Sierras Pampeanas, San Luis, are considered in these papers. Damourite stands out among the uranium minerals related to uraninite and coffinite. Pyrite, marcasite and other sulphides are found together with apatite and gummite. Autunite is the uranium secondary mineral more abundant. A mineralization with epigenetic contribution by circulating solutions is suggested to the studied area. (Author)
Making Borges. The Early Reception of Jorge Luis Borges's Work in France and the United States
Wijnterp, L.
This thesis analyzes the role of individual mediators in the early reception of the works of the Argentine writer Jorge Luis Borges (1899-1986). It focuses on a number of key mediators such as publishers, editors, translators, and critics in the translation and publication process and in criticism
Luis José de Tejada y Guzmán : espejo de peregrinos penitentes
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Darío Achury Valenzuela
Full Text Available Graciela Maturo, docta escritora argentina, ha escrito un estudio documentado y erudito bajo el rubro de Luis de Tejada y su peregrino místico, editado por el Instituto de Literatura Argentina "Ricardo Rojas", de la Universidad de Buenos Aires.
Black bear abundance, habitat use, and food habits in the Sierra San Luis, Sonora, Mexico
Rodrigo Sierra Corona; Ivan A. Sayago Vazquez; M. del Carmen Silva Hurtado; Carlos A. Lopez Gonzalez
We studied black bears to determine habitat use, food habits, and abundance between April 2002 and November 2003 in the Sierra San Luis, Sonora. We utilized transects to determine spoor presence, camera traps for abundance, and scat analysis. During 2002, bears fed principally on plant material, and for 2003 on animal matter, namely livestock. Habitat use differed...
Evaluating the sustainability of a regional system using Fisher information in the San Luis Basin, Colorado
This paper describes the theory, data, and methodology necessary for using Fisher information to assess the sustainability of the San Luis Basin (SLB) regional system over time. Fisher information was originally developed as a measure of the information content in data and is an ...
Green Net Regional Product for the San Luis Basin, Colorado: An Economic Measure of Regional Sustainability
This paper presents the data sources and methodology used to estimate Green Net Regional Product (GNRP), a green accounting approach, for the San Luis Basin (SLB). GNRP is equal to aggregate consumption minus the depreciation of man-made and natural capital. We measure the move...
Blue oak plant communities of southern San Luis Obispo and northern Santa Barbara Counties, California
Mark I. Borchert; Nancy D. Cunha; Patricia C. Krosse; Marcee L. Lawrence
An ecological classification system has been developed for the Pacific Southwest Region of the Forest Service. As part of that classification effort, blue oak (Quercus douglasii) woodlands and forests of southern San Luis Obispo and northern Santa Barbara Counties in Los Padres National Forest were classified into I3 plant communities using...
San Luis Valley - Taos Plateau Landscape-Level Cultural Heritage Values and Risk Assessment
Energy Technology Data Exchange (ETDEWEB)
Wescott, Konstance L. [Argonne National Lab. (ANL), Argonne, IL (United States); Abplanalp, Jennifer M. [Argonne National Lab. (ANL), Argonne, IL (United States); Brown, Jeff [Bureau of Land Management, Monte Vista, CO (United States); Cantwell, Brian [Argonne National Lab. (ANL), Argonne, IL (United States); Dicks, Merrill [Bureau of Land Management, Taos, NM (United States); Fredericks, Brian [Bureau of Land Management, Monte Vista, CO (United States); Krall, Angie [US Forest Service, Creede, CO (United States); Rollins, Katherine E. [Argonne National Lab. (ANL), Argonne, IL (United States); Sullivan, Robert [Argonne National Lab. (ANL), Argonne, IL (United States); Valdez, Arnie [Univ. of New Mexico, Albuquerque, NM (United States); Verhaaren, Bruce [Argonne National Lab. (ANL), Argonne, IL (United States); Vieira, Joseph [Bureau of Land Management, Monte Vista, CO (United States); Walston, Lee [Argonne National Lab. (ANL), Argonne, IL (United States); Zvolanek, Emily A. [Argonne National Lab. (ANL), Argonne, IL (United States)
The San Luis Valley – Taos Plateau Landscape-Level Cultural Heritage Values and Risk Assessment (hereafter referred to as cultural assessment) is a BLM pilot project designed to see whether the Rapid Ecoregional Assessment (REA) framework (already established and implemented throughout many ecoregions in the West) can be applied to the cultural environment.
Emphatic or Reflexive? On the Endophoric Character of French "lui-meme" and Similar Complex Pronouns.
Zribi-Hertz, Anne
This study examined the referential properties of a class of complex pronouns labelled M-Pronouns, exemplified by Old English "himself," French "lui-meme," and English "his own." It is shown that M-Pronouns exhibit some properties commonly taken as characterizing reflexive anaphors, and that they also occur as…
Profesor Luis López de Mesa. Reminiscencias
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J. Hernando Ordoñez
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El 18 de Octubre pasado se cumplieron 30 años de la muerte del Profesor Luis López de Mesa, fecha luctuosa para la cultura americana. Con tal motivo quiero revivir su memoria y rendirle un cálido homenaje de gratitud y admiración, haciendo reminiscencias de hechos y anécdotas vividas gracias a la cordial amistad que me permitió apreciar la grandeza de su personalidad, que brilló con luz propia en todos los campos del saber humano, que lo llevó a escalar sitio de honor entre los grandes humanistas del continente.
Sería un atrevimiento de mi parte, dada la poquedad de mis recursos literarios, intentar una biografía del profesor López de Mesa, tanto más, cuando eminentes autores han escrito obras magistrales relatando y exaltando las múltiples facetas de su excepcional cultura.
Mi propósito es modesto: no he de referirme a su actuación como fundador del Colegio Máximo de las Academias Colombianas, ni de su hija "Bahía Solano", ni del brillo con que desempeñó cargos tan importantes como Rector de la Universidad Nacional, Ministro de Educación Nacional y de Relaciones Exteriores, miembro de las más prestigiosas sociedades científicas y culturales, tanto nacionales como extranjeras, autor de numerosas obras a cual más eruditas, originales y profundas, y tantos títulos, cargos y actuaciones, que me sería largo enumerar.
La sencillez y su modestia fueron admirables, como han sido las de los grandes genios. No conoció la vanidad ni el orgullo. Casi me atrevería a pensar que no se dio cuenta de su propia grandeza, a pesar de los múltiples y más variados elogios, honores y homenajes que le rendían tanto en el ambiente nacional como en el internacional, donde contaba con la admiración de los más brillantes exponentes de la cultura, que, distantes, se admiran recíprocamente, como de lejos se divisan y se contemplan las más elevadas cumbres de las monta
Ln3+ (Ln=Ce, Tb, Dy) and Hf doping of LuI3 powders – A material and spectroscopic study
International Nuclear Information System (INIS)
Wiatrowska, Aneta; Keur, Wilco; Ronda, Cees
The moisture sensitivity of LuI 3 :Ce,Hf and luminescent properties of undoped LuI 3 and LuI 3 :M (M=Ce 3+ , Tb 3+ , Dy 3+ ) powders were investigated. The possibility of improving the air and moisture stability of LuI 3 :Ce by Hf doping was tested. It was proven that the Hf contribution to the LuI 3 :Ce stability is very limited and is insignificant to render LuI 3 :Ce scintillator powders suitable for applications. Photoluminescence results of LuI 3 without dopants added on purpose showed luminescence due to a plurality of rare-earth elements' impurities. Two types of self-trapped luminescence were found. Energy transfer between host lattice, self-trapped excitons and rare-earth ions was investigated.
Amphibians and reptiles of the state of San Luis Potosí, Mexico, with comparisons with adjoining states
Lemos-Espinal, Julio A.; Smith, Geoffrey R.; Woolrich-Piña, Guillermo A.
Abstract A summary of the species of amphibians and reptiles of the state has been compiled, including their geographic distributions, habitats, and conservation statuses. The herpetofauna of San Luis Potosí consists of 41 species of amphibians and 141 species of reptiles. San Luis Potosí shares the highest number of species with Hidalgo and Tamaulipas, and the least number of species with Nuevo León. In San Luis Potosí, there are several taxa of particular conservation concern including salamanders, emydid and trionychid turtles, anguid and xenosaurid lizards, and natricid and colubrid snakes. PMID:29731682
Amphibians and reptiles of the state of San Luis Potosí, Mexico, with comparisons with adjoining states.
Lemos-Espinal, Julio A; Smith, Geoffrey R; Woolrich-Piña, Guillermo A
A summary of the species of amphibians and reptiles of the state has been compiled, including their geographic distributions, habitats, and conservation statuses. The herpetofauna of San Luis Potosí consists of 41 species of amphibians and 141 species of reptiles. San Luis Potosí shares the highest number of species with Hidalgo and Tamaulipas, and the least number of species with Nuevo León. In San Luis Potosí, there are several taxa of particular conservation concern including salamanders, emydid and trionychid turtles, anguid and xenosaurid lizards, and natricid and colubrid snakes.
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Loehle, C.
The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.
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Alejandro Hermosilla Sánchez
Full Text Available In the entire Pitol's work, there is a continuous masquerade and an ungovernable fusion of the forces that link his life and his literature that has dislocated absolutely the "certainties" that we can get to own. Above all, for having been capable to improve the autobiographic genre helped by his way to understand, as Jorge Luis Borges and Marcel Schowb did, the reality as unverified and fiction as one more of many possibilities of what is "real". In this article, we will try to go deeper into the "discredit of the autobiographic and critical genre made by Sergio Pitol in La trilogía de la memoria thanks to the influence of Jorge Luis Borge´s literature.En toda la obra de Pitol hay un enmascaramiento continuo y una fusión ingobernable de las fuerzas que vinculan su vida y su literatura que ha terminado por dislocar absolutamente las "certezas" que podemos a llegar a poseer sobre ambas. Ante todo, por haber sido capaz de dar una nueva vuelta de tuerca más al género autobiográfico gracias a su manera de entender, tal y como hicieron Jorge Luis Borges y el francés Marcel Schwob, la realidad como inverificable y la ficción como una más de las muchas posibilidades de lo "real". En este artìculo, intentaremos profundizar en la desacreditación del género autobiográfico y crítico hecho por Pitol en La trilogía de la memoria o Domar a la divina garza gracias a la influencia de la literatura de Borges.
Mineralogical characterization of historical portuguese wall tiles of Sao Luis, Maranhao, Brazil; Caracterizacao mineralogica de azulejos portugueses do Centro Historico de Sao Luis do Maranhao
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Rivas Mercury, J.M.; Vasconcelos, N.S.L.S.; Cabral, A.A., E-mail: email@example.com [Instituto Federal de Educacao, Ciencia e Tecnologia do Maranhao (IFMA), Sao Luis, MA (Brazil). Programa de Mestrado em Engenharia de Materiais; Pereira, D.J. Costa [Centro de Criatividade Odylo Costa Filho (SECMA), Sao Luis, MA (Brazil). Centro Historico; Angelica, R.S. [Universidade Federal do Para (CG/UFPA), Belem, PA (Brazil). Inst. de Geociencias
Portuguese wall tiles from centuries, XVII, XVIII and XIX, found in Sao Luis Maranhao has been studied by X-ray diffraction, in order to interpret the possible raw material and burning temperature. The mineral phases, Quartz, Wollastonite, Calcite and Gehlenite were identified in all samples. Based on the results it is possible to affirm that the main raw materials used to manufacture this materials was probably mixtures of kaolinite clay and calcite. Based on the mineralogical information it was also possible to state that burning temperature of this wall tiles was lower than 1000 deg C. (author)
Seroprevalencia de sífilis en mujeres embarazadas en San Luis Potosí Seroprevalence of syphilis in pregnant women in San Luis Potosí
Daniel E Noyola; Octavio Malacara-Alfaro; Victoria Lima-Rogel; Abraham Torres-Montes
OBJETIVO: Determinar la seroprevalencia de sífilis en mujeres embarazadas. MATERIAL Y MÉTODOS: Encuesta seroepidemiológica en 1 857 mujeres que acudieron para la atención del parto a un hospital general de la ciudad de San Luis Potosí. RESULTADOS: Se diagnosticó sífilis en cinco (0.27%) mujeres al momento del parto. Los factores maternos asociados con una probabilidad superior de presentar sífilis incluyeron mayor edad materna, mayor número de embarazos previos y vivir en unión libre con su p...
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Fadi Wahab-El-Fatairi
Full Text Available In Venezuela and in the state Anzoátegui, the pneumocystosis, is little studied. To weigh that it is an infection opportunist caused by Pneumocystis jirovecii, it causes pneumonia of high morbility and mortality. The inmunocompromised patient is those that present bigger risks of acquiring this infection. The objectives of this investigation were to determine the infection frequency for P. jirovecii in patient with breathing symptoms and immunocompromised hospitalized in the Service of Internal Medicine of the Complex Hospital University "Dr. Luis Razetti", and to describe the clinical parameters, of laboratory, radiological and epidemic. To increase the sensibility of the diagnosis etiologic of the pneumocystosis you employment the combination of microscopic methods (Giemsa and direct immunofluorescence technique. 52 samples of spontaneous sputum were studied, which were processed by fluidification -concentration. Results: 8 patients (15.38% they were positive. The most frequent clinical manifestations among the patients with pneumocystosis were the dyspnea (75%, cough (62% and bullous (50% they were the most common signs among those infected, the one infiltrated alveolar (62.5% and the spill pleural (37.5% they prevailed as radiological signs. Was the LDH presented in values 300 UI/L in 5 of the positive patients. Other common discoveries were: moderate anemia and breathing alkalosis. The evaluated epidemic aspects were the gender, occupation, smoking, accumulation and comorbidities, in this last aspect, the diabetes, hypertension and infection for the VIH was opposing comorbidities among these patients. The confirmation of the infection in the state Anzoátegui, demonstrates that in this hospital the agent exists and probably you this underdiagnosticated the pneumocystosis.
Vida y obra de Luis Jiménez Moreno (1929-2007
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Antonio Jiménez García
Full Text Available Luis Jiménez Moreno passed away on 27 of October, 2007, 77 years old. For the last 30 years he was professor at Universidad Complutense de Madrid. He became Full Professor. He had studied in Salamanca, Roma, Valencia and München. He got a Ph. Degree whith a tesis about Nietzsche`s Antropological Thought by leading of José Luis López Aranguren. He was High School Teacher in Andujar, Ávila and Badalona; after he was professor at Universities of Barcelona and Madrid. This article develops information about his life and his works: books, articles, essays, conferences, papers to Congress, Symposios, Scientic meetings…
Commercial production of ethanol in the San Luis Valley, Colorado. Final report
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Hewlett, E.M.; Erickson, M.V.; Ferguson, C.D.; Boswell, B.S.; Walter, K.M.; Hart, M.L.; Sherwood, P.B.
The commercial feasibility of producing between 76 and 189 million liters (20 to 50 million gallons) of ethanol annually in the San Luis Valley, Colorado using geothermal energy as the primary heat source was assessed. The San Luis Valley is located in south-central Colorado. The valley is a high basin situated approximately 2316 meters (7600 feet) above sea level which contains numerous warm water wells and springs. A known geothermal resource area (IGRA) is located in the east-central area of the valley. The main industry in the valley is agriculture, while the main industry in the surrounding mountains is lumber. Both of these industries can provide feedstocks for the production of ethanol.
Doctor Ramón Luis Miranda Torres, su relación con las neurociencias
Hodelín Tablada,Ricardo
Objetivo: en el presente trabajo se reseña la relación del doctor Ramón Luis Miranda con las neurociencias, dirigido a destacar su inclinación por estas disciplinas. Desarrollo: conocido en la historiografía médica como el médico de José Martí el apóstol cubano el doctor Ramón Luis Miranda Torres, se destacó en otros aspectos poco divulgados, por lo que opinamos que no se le ha otorgado su verdadera dimensión. Nacido en la ciudad de Matanzas, Cuba, estudió medicina en Francia y desde sus años...
Commercial production of ethanol in the San Luis Valley, Colorado. Final Report
Energy Technology Data Exchange (ETDEWEB)
Hewlett, E.M.; Erickson, M.V.; Ferguson, C.D.; Sherwood, P.B.; Boswell, B.S.; Walter, K.M.; Hart, M.L.
The purpose of this study is to assess the commercial feasibility of producing between 76 and 189 million liters (20 and 50 million gallons) of ethanol annually in the San Luis Valley, Colorado using geothermal energy as the primary heat source. The San Luis Valley is located in south-central Colorado. The valley is a high basin situated approximately 2316 meters (7600 feet) above sea level which contains numerous warm water wells and springs. A known geothermal resource area (KGRA) is located in the east-central area of the valley. The main industry in the valley is agriculture, while the main industry in the surrounding mountains is lumber. Both of these industries can provide feedstock for the production of ethanol.
Geology and petrography of the Socoscora Sierra . Province of San Luis. Republica Argentina
International Nuclear Information System (INIS)
Carugno Duran, A.
The following paper include an study geological and petrographic of the Sierra de Socoscora. San Luis, Argentina. This mountainas is a block with less elevation that the Sierra de San Luis, and it located in the west center of it. It' s formed by an crystalline basement composed by metamorphic haigh grade rocks, with a penetrative foliation of strike N-S. in this context is possible to define petrographicly the following units, migmatitic that fill a big part of the mountain, amphibolites, marbles, skarns, milonites and pegmatites. This units have amphibolitic facies assemblanges mineral and in some them, we can observe retrograde metamorphism of the greesnschist facies. The metamorphic structure is complex and evidence at least three deformation event
Airborne electromagnetic and magnetic survey data of the Paradox and San Luis Valleys, Colorado
Ball, Lyndsay B.; Bloss, Benjamin R.; Bedrosian, Paul A.; Grauch, V.J.S.; Smith, Bruce D.
In October 2011, the U.S. Geological Survey (USGS) contracted airborne magnetic and electromagnetic surveys of the Paradox and San Luis Valleys in southern Colorado, United States. These airborne geophysical surveys provide high-resolution and spatially comprehensive datasets characterizing the resistivity structure of the shallow subsurface of each survey region, accompanied by magnetic-field information over matching areas. These data were collected to provide insight into the distribution of groundwater brine in the Paradox Valley, the extent of clay aquitards in the San Luis Valley, and to improve our understanding of the geologic framework for both regions. This report describes these contracted surveys and releases digital data supplied under contract to the USGS.
Reduced blood nrf-2 mRNA in local overweight boys at risk of metabolic complications: a study in San Luis City, San Luis, Argentina.
Santillán, Lucas D; Moyano, Marta; Frau, Martín; Flores, Orlando; Siewert, Susana; Zirulnick, Fanny; Ramirez, Dario C; Giménez, Maria S
Childhood overweight (OW) is a matter of public health concern because of its long-term impact on adulthood health. NF-E2-related factor 2 (Nrf-2) regulates the antioxidant/lipogenic response to a sustained positive energy balance that prevails during weight gain. Here we aimed at studying a possible link between OW and Nrf-2-dependent antioxidant/lipogenic response in a local population of boys at risk of metabolic complications. We measured clinical and biochemical parameters related to lipid metabolism, oxidative stress, and metabolic syndrome in a population of OW boys [body mass index (BMI) percentile ≥85(th) and Luis City, San Luis, Argentina. Compared to NW, OW boys had lower insulin sensitivity, an altered plasma lipid profile, and increased markers of oxidative stress and inflammatory fatty acids. OW boys also had a higher atherogenic index and peripheral insulin resistance than NW boys. We also found that glutathione peroxidase activity and the reduced glutathione to oxidized glutathione ratio were lower in OW boys than NW boys, suggesting that OW boys may have an altered antioxidant response to oxidative stress. Finally, Nrf-2 expression negatively correlated with metabolic syndrome parameters in OW boys. Our data suggest that OW boys have a reduced antioxidant and lipogenic response to a positive energy balance, resulting in oxidative stress, insulin resistance, and risk of developing metabolic complications. Our data also provide a rationale for nutritional interventions aimed at restoring Nrf-2 expression to reduce the risk of metabolic complications in OW boys.
Behemoth, Lilith e Anjos: três monstros judaicos em Jorge Luis Borges
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Marcos Fábio de Faria
Full Text Available Análise dos verbetes de monstros judaicos recriados por Jorge Luis Borges em Manual de zoologia fantástica e O livro dos seres imaginários, a saber: Behemoth, Lilith e os anjos Haniel, Kazfiel, Azriel e Aniel. As múltiplas representações e versões desses verbetes, bem como seu diálogo com a Torah e sua inscrição na literatura.
Luis Ramiro Beltrán: Semblanza de un comunicador vanguardista
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Alfonso Gumucio Dagron
Full Text Available Luis Ramiro Beltrán es un "WAKIKI" investigador de seriedad académica reconocida, pensador que ha dado un aporte significativo a los estudios sobre la comunicación para el desarrollo en América Latina son frases de Alfonso Gumucio al hacer una semblanza de Beltrán en la que destaca su generosidad, apertura tolerancia y colaboración, amigo fiel, constante e incondicional y su creatividad.
A propósito de José Luis Brea: del archivo a la RAM
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Fernando Broncano
Full Text Available The philosopher José Luis Brea proposes a notion of memory spread around a network of connections, which reveals a conception of culture based on a RAM structure and contrary to the culture of archive. The underwent changes in the classification of disciplines caused by individual's attitudes deriving from the new media hyperconnectivity environment will be reviewed here and the relevance in the present humanities of concepts such as exile, frontier and question without answer.
"Non qua servus est, sed qua homo." Der rechtliche Status von Sklaven bei Luis de Molina
Simmermacher, Danaë
Luis de Molina (1535-1600) grants slaves a legal status through which they can take up a position with respect to their masters between equivalent legal entity and legal object. Here, what is decisive is the figure of the subjective right, which both for Molina and modern proponents of this legal concept describes the 'right per se'. According to Molina's definition of ius, the denial of a subjective right or the hindrance of exercising an individual right represents an injustice. The rights ...
Real-Time Water Quality Monitoring and Habitat Assessment in the San Luis National Wildlife Refuge
Quinn, Nigel W.T.; Hanlon, Jeremy S.; Burns, Josephine R.; Stromayer, Karl A.K.; Jordan, Brandon M.; Ennis, Mike J.; Woolington, Dennis W.
The project report describes a two year experiment to control wetland drainage to the San Joaquin River of California from the San Luis National Wildlife Refuge using a decision support system for real-time water quality management. This system required the installation and operation of one inlet and three drainage flow and water quality monitoring stations which allowed a simnple mass balance model to be developed of the seasonally managed wetlands in the study area. Remote sensing meth...
Pionero de la comunicación (Entrevista a Luis Ramiro Beltrán
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Juan Braun
Full Text Available Luis Ramiro es, sin lugar a dudas, el comunicador más reconocido de la América Latina. Sus ideas circulan libremente en el Norte y en el Sur. Es un líder. Pero pocos saben de su vida. Los esfuerzos que tuvo que hacer para "llegar". De sus primeros años de periodista bohemio, su lucha en la Universidad del Estado de Michigan para sobrevivir a las exigencias de Berlo, Kumata, Rogers y Miller. Y la importancia fundamental en todo esto de su madre, Mama Becha. Nos conocimos allá lejos, en Michigan. Luis Ramiro se graduaba de Doctor, terminaba su "vía crucis". El mío apenas comenzaba. Las ideas de Luis, su diagnóstico de la comunicación en América Latina, tuvieron un profundo impacto en mí que se hizo sentir años después. ¡Gracias! ¡y también alcancé a probar las empanadas de Mama Becha! El Dr. Beltrán habla sobre su vida y el pasado, presente y futuro de la comunicación en América Latina.
Theoretical investigations on the high light yield of the LuI3:Ce scintillator
International Nuclear Information System (INIS)
Vasil'ev, A.N.; Iskandarova, I.M.; Scherbinin, A.V.; Markov, I.A.; Bagatur'yants, A.A.; Potapkin, B.V.; Srivastava, A.M.; Vartuli, J.S.; Duclos, S.J.
The extremely high scintillation efficiency of lutetium iodide doped by cerium is explained as a result of at least three factors controlling the energy transfer from the host matrix to activator. We propose and theoretically validate the possibility of a new channel of energy transfer to excitons and directly to cerium, namely the Auger process when Lu 4f hole relaxes to the valence band hole with simultaneous creation of additional exciton or excitation of cerium. This process should be efficient in LuI 3 , and inefficient in LuCl 3 . To justify this channel, we perform calculations of density of states using a periodic plane-wave density functional approach. The second factor is the increase of the efficiency of valence hole capture by cerium in the row LuCl 3 -LuBr 3 -LuI 3 . The third one is the increase of the efficiency of energy transfer from self-trapped excitons to cerium ions in the same row. The latter two factors are verified by cluster ab initio calculations. We estimate either the relaxation of these excitations and barriers for the diffusion of self-trapped holes (STH) and self-trapped exciton (STE). The performed estimations theoretically justify the high LuI 3 :Ce 3+ scintillator yield.
Homoparentalidad: explorando el reconocimiento social y los derechos de los homosexuales en la ciudad de San Luis, Argentina
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Yael guadalupe Calvo Laméndola
Full Text Available Abstract This research paper deals with the opinions of practitioners working in the field of health care, education and law in the city of San Luis on homosexual parenting, and its possible effects in the psychological development of children adopted by homosexual couples. A descriptive-exploratory study was conducted with the aim of making a preliminary approach to this issue, which made it possible to establish the common-sense knowledge referred to above. The sample was composed of 21 individuals, five pediatricians, five lawyers, five teachers and six psychologists. The purpose of this presentation is to communicate the results obtained in one of the four dimensions of the analysis. Said results were obtained before the implementation of the Egalitarian Marriage Act. The results obtained in relation to this dimension reveal that almost all homosexual couples should have the same rights as any other citizen, except that to forming a family by adopting a child. It is important to note that, when answering to the questions; many professionals did not know whether to adhere to the principles of their profession, or to their personal opinion. Resumen El presente artículo de investigación indaga por las opiniones de profesionales del ámbito de la salud, educación y jurídico de la ciudad de San Luis acerca de la homoparentalidad y sus posibles consecuencias en el desarrollo psicológico de niños adoptados por parejas homosexuales. Se realizó un estudio exploratorio de carácter descriptivo, en tanto la finalidad de esta investigación consistía en lograr un primer acercamiento a la problemática en estudio para reconocer el sentido común referido a ella. La muestra quedó finalmente conformada por 21 sujetos: cinco médicos pediatras, cinco abogados, cinco docentes y seis psicólogos. El fin concreto es difundir los resultados obtenidos en una de las cuatro dimensiones de análisis, y fueron recolectados antes de que se promulgara la Ley
Queen's discovery lauded by top scientific journal
McGrady, S
A scientific breakthrough at Queen's University's Sudbury Neutrino Observatory has received major international recognition. The journal Science ranked the discovery that cracked the "neutrino problem" second, in the journal's top 10 scientific achievements of 2002 (1/2 page).
METROPOLlZAÇÃO NA ILHA OE SÃO LUIS E SEUS IMPACTOS SANITÁRIOS E AMBIENTAIS
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Lúcio Antônio Alves de Macêdo
Full Text Available The paper presents aspects 01 the Environmental Sanitation considered on the island 01 Maranhão, lrom a historical perspective, restoring the role 01 sanitation in improving the quality 01 lile and highlighting the low leveis 01 coverage 01 water supply (56% and sanitation (12%, and the precariousness 01 the disposal 01 solid waste in the municipalities 01 São Luis, Paço do Lumiar, Raposa and São José de Ribamar. ln particular there is no more available land lar construction 01 landlills, because 01 environmental implications in areas 01 watershed protection. As a result 01 the studies showed that water pollution in major rivers 01 the island with the pollution load 0160 ton / day, committing the multiple uses 01 the river Anil, Bacanga, Patience and Tibiri, as well as high rates 01 inlectious diseases and child mortality the precariousness 01 Sanitation problems associated with the generation 01 700 t / d 01 waste. ln conclusion the study shows the need lar the implementation 01 environmental planning, ordering the use 01 space and adopting techniques 01 control and environmental health lar the population.
Regeneracionismo, socialismo y escepticismo en Luis Araquistáin
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Rivera García, Antonio
Full Text Available This article analyses those philosophical-political positions that will always be found in Araquistáin, beyond the fact that this socialist goes through different phases of greater or lesser political radicalism. Araquistáin remained always faithful to a regenerationist vision of the problem of Spain. He was an accidentalist, his socialism had a clear neo-Kantian inspiration and he always preferred a philosophy of sceptical or relativist orientation. However, it was from his period of exile, in the last stages of his life, that all those elements achieved a greater coherence and harmony.Este artículo analiza aquellas posiciones filosófico-políticas que siempre encontraremos en Araquistáin, más allá de que este socialista pase por diversas fases de mayor o menor radicalismo político. Araquistáin permaneció fiel a una visión regeneracionista del problema de España, fue accidentalista, su socialismo tuvo una clara inspiración neokantiana y prefirió por lo general una filosofía de orientación escéptica o relativista. No obstante, fue en el período del exilio, en la última etapa de su vida, cuando todos esos elementos lograron una mayor coherencia y armonía.
El satisfecho: fama y fortuna de una comedia desconocida de Luis Belmonte (El satisfecho: fame and fortune of an unknown comedy by Luis Belmonte
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Elisa Domínguez de Paz
Full Text Available Resumen: Este artículo ofrece un estudio del manuscrito autógrafo de la comedia, El satisfecho, firmado por el dramaturgo Luis Belmonte en Sevilla, el 24 de Julio de 1634. El documento proporciona buena información acerca de su recorrido por el tiempo, desde que obtiene la licencia de representación en Lisboa, en 1639, hasta que aparece en Toro, en 1653, como propiedad de Santiago Manteca. El manuscrito resulta muy interesante por la gran cantidad de probationes pennae, de contenido variado y ajeno al asunto teatral, que contiene. Estos ejercicios de escritura, salidos todos ellos de la pluma de Santiago Manteca, revelan que el escribano es un hombre preocupado por el mundo documental y formulístico. Su poco interés por conservar limpio el documento indica, por un lado, que , tal vez, la comedia ya no tenía éxito y, por otro lado, la más que probable desconexión de Manteca del mundo teatral.Abstract: This article studies an autographic manuscript of the comedy, El satisfecho, signed by the playwright Luis Belmonte in Seville, on July 24 1634. The document provides sound information about its journey through time, from the moment when it obtained its representation permit in Lisbon, in 1639, until it appeared in Toro, property of Santiago Manteca. The interest of the manuscript is very high due to the great number of probationes pennae that it contains, of very varied content and unrelated to the world of theatre. These writing exercises, coming out of Santiago Mantecas pen, reveal that the secretary was a man concerned about the documental and formulaic world. His lack of interest in keeping the document clean may indicate, on the one hand, that the comedy was not successful any more, and, on the other, Mantecas likely disconnection from the theatrical world.
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Melody Celeste Vera
Full Text Available La base fundamental de la identidad de los habitantes de la provincia de San Luis (Argentina y de su historiografía, es el axioma que el pueblo puntano se inmoló por el proyecto sanmartiniano. El Gobernador Intendente Vicente Dupuy (1814-1820 fue el principal colaborador de José de San Martin en la provincia, y el coordinador de las donaciones de bienes y vidas para la causa. Contaba con el apoyo del "cabildo sanmartiniano", un grupo de vecinos que secundaban sus ideales, apoyaban sus iniciativas y colaboraban materialmente. Pero luego de la caída del gobierno central en 1820 no se ofrece una interpretación sobre el cambio de proyecto político que representó el nuevo Gobernador, José Santos Ortiz (1820-1829. Si se consideran conjuntamente las oposiciones de un grupo de vecinos levantadas durante el gobierno de Dupuy y el accionar de Santos Ortiz durante su mandato, cabe preguntarse: ¿los cabildantes terratenientes apoyaron la gesta sanmartiniana por convicción, o se vieron forzados a hacerlo por la imposición de un grupo en el poder? ¿Representó Santos Ortiz el proyecto de lo que el grupo terrateniente buscaba y no pudo obtener mientras se llevaba delante el plan sanmartiniano? En este trabajo se busca comparar los objetivos primarios de ambos gobernadores durante sus mandatos, con el fin de vislumbrar cuál de los planes de gobierno representaba los ideales y necesidades de los grandes terratenientes de la ciudad de San Luis.
Abasto futuro de agua potable, análisis espacial y vulnerabilidad de la ciudad de San Luis Potosí, México
Contreras Servín Carlos; Galindo Mendoza María Guadalupe
En el presente artículo se analizan y se presentan las circunstancias físicas, sociales y económicas que en conjunto afectan al panorama y a la problemática actual del abastecimiento de agua potable de la zona metropolitana de la ciudad de San Luis Potosí. Entre los temas que se abordan se encuentra la relación entre la disponibilidad del agua y el incremento de la población, así como la evolución de la extracción de aguas subterráneas. Por otra parte, la investigación muestra un diagnóstico ...
Usability of Discovery Portals
Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.
As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals are not spatial data experts but professionals with limited spatial knowledge, and a focus outside the spatial domain. An exploratory usability experiment was carried out in which three discovery p...
Uranium series isotopes concentration in sediments at San Marcos and Luis L. Leon reservoirs, Chihuahua, Mexico
Méndez-García, C.; Renteria-Villalobos, M.; García-Tenorio, R.; Montero-Cabrera, M. E.
Spatial and temporal distribution of the radioisotopes concentrations were determined in sediments near the surface and core samples extracted from two reservoirs located in an arid region close to Chihuahua City, Mexico. At San Marcos reservoir one core was studied, while from Luis L. Leon reservoir one core from the entrance and another one close to the wall were investigated. 232Th-series, 238U-series, 40K and 137Cs activity concentrations (AC, Bq kg-1) were determined by gamma spectrometry with a high purity Ge detector. 238U and 234U ACs were obtained by liquid scintillation and alpha spectrometry with a surface barrier detector. Dating of core sediments was performed applying CRS method to 210Pb activities. Results were verified by 137Cs AC. Resulting activity concentrations were compared among corresponding surface and core sediments. High 238U-series AC values were found in sediments from San Marcos reservoir, because this site is located close to the Victorino uranium deposit. Low AC values found in Luis L. Leon reservoir suggest that the uranium present in the source of the Sacramento - Chuviscar Rivers is not transported up to the Conchos River. Activity ratios (AR) 234U/overflow="scroll">238U and 238U/overflow="scroll">226Ra in sediments have values between 0.9-1.2, showing a behavior close to radioactive equilibrium in the entire basin. 232Th/overflow="scroll">238U, 228Ra/overflow="scroll">226Ra ARs are witnesses of the different geological origin of sediments from San Marcos and Luis L. Leon reservoirs.
Uranium series isotopes concentration in sediments at San Marcos and Luis L. Leon reservoirs, Chihuahua, Mexico
Energy Technology Data Exchange (ETDEWEB)
Méndez-García, C.; Montero-Cabrera, M. E., E-mail: email@example.com [Centro de Investigación en Materiales Avanzados, CIMAV, Miguel de Cervantes 120, 31109, Chihuahua, Chihuahua (Mexico); Renteria-Villalobos, M. [Facultad de Zootecnia y Ecología Universidad Autónoma de Chihuahua, Periferico Francisco R. Almada Km 1, 31410, Chihuahua (Mexico); García-Tenorio, R. [Applied Nuclear Physics Group, University of Seville, ETS Arquitectura, Avda. Reina Mercedes s/n, 41012 Seville (Spain)
Spatial and temporal distribution of the radioisotopes concentrations were determined in sediments near the surface and core samples extracted from two reservoirs located in an arid region close to Chihuahua City, Mexico. At San Marcos reservoir one core was studied, while from Luis L. Leon reservoir one core from the entrance and another one close to the wall were investigated. ²³²Th-series, ²³⁸U-series, ⁴⁰K and ¹³⁷Cs activity concentrations (AC, Bq kg⁻¹) were determined by gamma spectrometry with a high purity Ge detector. ²³⁸U and ²³⁴U ACs were obtained by liquid scintillation and alpha spectrometry with a surface barrier detector. Dating of core sediments was performed applying CRS method to ²¹⁰Pb activities. Results were verified by ¹³⁷Cs AC. Resulting activity concentrations were compared among corresponding surface and core sediments. High ²³⁸U-series AC values were found in sediments from San Marcos reservoir, because this site is located close to the Victorino uranium deposit. Low AC values found in Luis L. Leon reservoir suggest that the uranium present in the source of the Sacramento – Chuviscar Rivers is not transported up to the Conchos River. Activity ratios (AR) ²³⁴U/²³⁸U and ²³⁸U/²²⁶Ra in sediments have values between 0.9–1.2, showing a behavior close to radioactive equilibrium in the entire basin. ²³²Th/²³⁸U, ²²⁸Ra/²²⁶Ra ARs are witnesses of the different geological origin of sediments from San Marcos and Luis L. Leon reservoirs.
Uranium series isotopes concentration in sediments at San Marcos and Luis L. Leon reservoirs, Chihuahua, Mexico
International Nuclear Information System (INIS)
Méndez-García, C.; Montero-Cabrera, M. E.; Renteria-Villalobos, M.; García-Tenorio, R.
Spatial and temporal distribution of the radioisotopes concentrations were determined in sediments near the surface and core samples extracted from two reservoirs located in an arid region close to Chihuahua City, Mexico. At San Marcos reservoir one core was studied, while from Luis L. Leon reservoir one core from the entrance and another one close to the wall were investigated. 232 Th-series, 238 U-series, 40 K and 137 Cs activity concentrations (AC, Bq kg −1 ) were determined by gamma spectrometry with a high purity Ge detector. 238 U and 234 U ACs were obtained by liquid scintillation and alpha spectrometry with a surface barrier detector. Dating of core sediments was performed applying CRS method to 210 Pb activities. Results were verified by 137 Cs AC. Resulting activity concentrations were compared among corresponding surface and core sediments. High 238 U-series AC values were found in sediments from San Marcos reservoir, because this site is located close to the Victorino uranium deposit. Low AC values found in Luis L. Leon reservoir suggest that the uranium present in the source of the Sacramento – Chuviscar Rivers is not transported up to the Conchos River. Activity ratios (AR) 234 U/ 238 U and 238 U/ 226 Ra in sediments have values between 0.9–1.2, showing a behavior close to radioactive equilibrium in the entire basin. 232 Th/ 238 U, 228 Ra/ 226 Ra ARs are witnesses of the different geological origin of sediments from San Marcos and Luis L. Leon reservoirs
Usability of Discovery Portals
Bulens, J.D.; Vullings, L.A.E.; Houtkamp, J.M.; Vanmeulebrouk, B.
As INSPIRE progresses to be implemented in the EU, many new discovery portals are built to facilitate finding spatial data. Currently the structure of the discovery portals is determined by the way spatial data experts like to work. However, we argue that the main target group for discovery portals
International Nuclear Information System (INIS)
''Discovery and the Atom'' tells the story of the founding of nuclear physics. This programme looks at nuclear physics up to the discovery of the neutron in 1932. Animation explains the science of the classic experiments, such as the scattering of alpha particles by Rutherford and the discovery of the nucleus. Archive film shows the people: Lord Rutherford, James Chadwick, Marie Curie. (author)
Mineralogical characterization of historical portuguese wall tiles of Sao Luis, Maranhao, Brazil
International Nuclear Information System (INIS)
Rivas Mercury, J.M.; Vasconcelos, N.S.L.S.; Cabral, A.A.; Pereira, D.J. Costa; Angelica, R.S.
Portuguese wall tiles from centuries, XVII, XVIII and XIX, found in Sao Luis Maranhao has been studied by X-ray diffraction, in order to interpret the possible raw material and burning temperature. The mineral phases, Quartz, Wollastonite, Calcite and Gehlenite were identified in all samples. Based on the results it is possible to affirm that the main raw materials used to manufacture this materials was probably mixtures of kaolinite clay and calcite. Based on the mineralogical information it was also possible to state that burning temperature of this wall tiles was lower than 1000 deg C. (author)
On editing the fifth stanza of El aire se serena by fray Luis
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Aquilino Suárez Pallasá
Full Text Available Although many scholars and editors of the ode «El aire se serena» by fray Luis de León have denied or questioned the authenticity of its fifth stanza, there now seems to be a general assent to its acceptance. The reason for such a change of heart has not to do with textual criticism proper, but with literature. The sources of the ode are said to justify it. In this paper a strictly critico-textual demonstration of the authenticity of stanza 5 is proposed, placing emphasis on the cause of the diffraction displayed in the erroneous lectiones of a segment of the stanza.
Las dos Celamas de Luis Mateo Díez: recuerdo y olvido
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Oscar Bazán Rodríguez
Full Text Available El artículo reflexiona sobre el tratamiento del espacio en la trilogía de Luis Mateo Díez, El reino de Celama. Con un diverso aporte teórico y crítico explica la relación intrínseca que ocurre entre el espacio y sus habitantes en la obra, y postula que implícitamente hay una separación entre dos Celamas que, a pesar de ocupar un mismo espacio, son distintas en el tiempo, y se corresponden con los valores del recuerdo (luz y del olvido (oscuridad.
Missionary Pragmalinguistics: Father Diego Luis de Sanvitores' grammar (1668) within the tradition of Philippine grammars
Winkler, A.P.
The grammar written in Latin, in 1668, by the Jesuit missionary Father Diego Luis de Sanvitores (1627-1672) is the oldest description we have of Chamorro, a language spoken on the Mariana islands. The grammar received a number of bad reviews and as a consequence has become neglected and almost forgotten. The main point of criticism has been that Sanvitores used the Latin grammatical framework to explain a language that in many ways does not fit this framework. In this thesis it is argued inst...
Entrevista con Luis Ramiro Beltrán Salmón
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Fanny Patricia Franco Chávez
Full Text Available Luis Ramiro Beltrán es un personaje obligado a la hora de hablar de la relación entre la comunicación y el desarrollo. En la siguiente entrevista, conocemos la génesis de este campo a través de un personaje que nos comparte su perfil como pionero y sus experiencias iniciales en Latinoamérica para acercarnos a las primeras definiciones de este campo y a lo que debe ser esencial en la formación del perfil de un comunicador para el desarrollo social.
Yacimientos de Celestina en la Plataforma Valles-San Luis Potosí
Rocha Rocha, Macario
En la zona de estudio, la Plataforma Valles-San Luis Potosí (PVSLP), existen depósitos de celestina; las características geotectónicas de la zona, hacen pensar que estos depósitos se asocian con evaporitas del Jurásico Superior-Cretácico Inferior. La mineralización de celestina arma en la Formación El Abra y en menor grado la Formación Indidura, en forma de vetas, mantos, zonas de brecha y cuerpos irregulares. La mineralogía consiste básicamente de celestina y algunos minerales...
Introducción [Jorge Luis Borges : Translación e Historia
de Toro, Alfonso
El presente volumen es el resultado de una selección de las ponencias presentadas en el coloquio internacional "Jorge Luis Borges: Translación e Historia" realizado con el auspicio de la Deutsche Forschungsgemeinschaft en el Centro de Investigación Iberoamericana del 4 al 9 de diciembre de 2007 y pone en el centro de su reflexión a Borges como fenómeno de "translación", entendiendo por el concepto de "translación" un complejo proceso cultural, medial, social y pragmasemiótico que abarca tanto...
Prevalence and spatial distribution of bovine brucellosis in San Luis and La Pampa, Argentina.
Aznar, M N; Linares, F J; Cosentino, B; Sago, A; La Sala, L; León, E; Duffy, S; Perez, A
Bovine brucellosis (BB) is a zoonotic disease caused by Brucella abortus. BB is endemic in Argentina, where vaccination with Brucella abortus strain 19 is compulsory for 3-to-8 month-old heifers. The objectives of this study were to quantify the prevalence of BB and to identify factors associated with its occurrence, along with the spatial distribution of the disease, in the provinces of La Pampa and San Luis. A two-stage random sampling design was used to sample 8,965 cows (3,513 in La Pampa and 5,452 in San Luis) from 451 farms (187 in La Pampa and 264 in San Luis). Cow and herd prevalence were 1.8 % (95 % CI: 1.3-2.2; n = 157) and 19.7 % (95 % CI: 17.0-22.4; n = 89), respectively. Both cow-level and herd-level prevalence in La Pampa (2.4 and 26.0 %, respectively) were significantly higher than in San Luis (1.4 and 15.5 %, respectively). There were not differences between the proportions of reactive cattle compared to that obtained in a survey conducted in 2005. However, herd prevalence in La Pampa was significantly (P < 0.05) higher compared to that study. Disease was found to be spatially clustered in west La Pampa. The lower the bovine density and the calf/cow ratio, the higher odds of belonging to the cluster. The increase of farm prevalence in the last five years suggests that the disease is spreading and that control measures should be applied in the region. The cluster of infected farms was located in the west region of La Pampa. There, farms have lower animal densities and smaller cow/calf indices compared to the rest of the province. Although western La Pampa has more infected herds, within-farm prevalence was not higher, which suggests that the control program has been relatively successful in controlling the disease at the farm level, and/or that low animal density inherently results in low disease prevalence. Our results provide baseline information on the epidemiology of BB and its potential pattern of transmission in Argentina, which will ultimately
Relación del entrenamiento, capacitación y financiamiento con el crecimiento sostenido de pequeñas empresas del sector industrial en la ciudad de San Luis Potosí, México.
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Mario Alberto Martínez Rojas
Full Text Available The research does an analysis about the sustainable growth challenge´s in relation with the independents variables of the small business in front the context of the economic globalization, the issue of the sustainable growth, the characterization statistic and the empiric´s studies, and fi nally the analysis of the smalls business of the San Luis Potosi. It was realized a statistic study with a sample comprehend with 30 companies. The most relevant discoveries is that the managers possess enough knowledge as much academic as experience, this demonstrate that those variables are a critical factor to the sustainable growth of the small business, in the other hand the fi nancing is not a determinant factor.
El pachuco entre Octavio Paz y el trayecto para su reinvención en "Zoot Suit" de Luis Valdez
Ochoa, Edna
This article focuses on the figure of the pachuco in the play Zoot Suit by Luis Valdez in order to explore the most important aspects about this character. To achieve this purpose I will examine its representation in various literary texts and I will trace its history to show how the projection of the character changes from the Chicano movement in the 6os. This character is seen in a positive and memorable way, especially in the play Zoot Suit by Luis Valdez, who regards him as...
Juizados Especiais e Ativismo Judicial à Luz de Luis Alberto Warat
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Zenildo Bodnar
Full Text Available This article addresses, in a punctual way, some reflections on the judicial activism in the Special Courts camp. It seeks to evaluate the existence of a place for the conciliator in the stir that permeates the procedural and substantial models of legal proceedings. For this, as theoretical references, the postulates of Luis Alberto Warat are used, in order to overcome such dyad in favor of an effective judicial protection, without following the ways of the Free Movement of Law and Instrumentality of Process. For the development of this research, it has been used the inductive method, operated by the operational concepts and techniques of literature.Resumo: O presente artigo aborda de forma pontual algumas reflexões sobre o ativismo judicial na seara dos Juizados Especiais. Procura-se avaliar a existência de um lugar para o conciliador na celeuma que permeia os modelos procedimentalistas e substancialistas de processo jurisdicional. Para tanto, como referencial teórico utiliza-se os postulados de Luis Alberto Warat no intuito de superar a referida díade em favor de uma tutela judicial efetiva, sem que se trilhe os caminhos do Movimento do Direito Livre e da Instrumentalidade do Processo. Utilizou-se, para o desenvolvimento desta pesquisa, o método indutivo, operacionalizado pelas técnicas de conceitos operacionais e da pesquisa bibliográfica.
Transient electromagnetic mapping of clay units in the San Luis Valley, Colorado
Fitterman, David V.; Grauch, V.J.S.
Transient electromagnetic soundings were used to obtain information needed to refine hydrologic models of the San Luis Valley, Colorado. The soundings were able to map an aquitard called the blue clay that separates an unconfined surface aquifer from a deeper confined aquifer. The blue clay forms a conductor with an average resistivity of 6.9 ohm‐m. Above the conductor are found a mixture of gray clay and sand. The gray clay has an average resistivity of 21 ohm‐m, while the sand has a resistivity of greater than 100 ohm‐m. The large difference in resistivity of these units makes mapping them with a surface geophysical method relatively easy. The blue clay was deposited at the bottom of Lake Alamosa which filled most of the San Luis Valley during the Pleistocene. The geometry of the blue clay is influenced by a graben on the eastern side of the valley. The depth to the blue clay is greater over the graben. Along the eastern edge of valley the blue clay appears to be truncated by faults.
Jorge Luis Borges y Wilhem Ostwald. Notas para una alianza entre la ciencia y las humanidades
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Lothar Beyer
Full Text Available Jorge Luis Borges (1899-1986 de nacionalidad argentina, fue escritor, poeta y filósofo de fama mundial. Wilhelm Ostwald (1853-1932, de nacionalidad alemana, fue uno de los fundadores de la físicoquímica.También fue filósofo, pintor y premio Nobel de Química (1909. Los dos hombres enriquecieron el diálogo entre ciencia y humanidades gracias a sus obras y sus discursos, a pesar de que nunca se conocieron personalmente.Un simposio en la ciudad de Leipzig, en cuya universidad Wilhelm Ostwald se desempeñó durante 20 años como catedrático principal de físicoquímica, realizado en octubre de 2001, tenía el título: «Jorge Luis Borges. Ciencia y filosofía». A ese simposio el autor de este artículo contribuyó con una conferencia: «Ciencias y humanidades en diálogoconstructivo» dictada en presencia de la viuda María Kodama de Borges.
Luis Buñuel: trascendiendo el tópico
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Dr. Manuel Carlos Fernández Sánchez
Full Text Available En 1900 nace el cineasta Luis Buñuel en Calanda, Aragón. En el año 2000 se celebró en distintos ámbitos cinematográficos y televisivos de todo el mundo el centenario de su nacimiento. Festivales de cine, cadenas de televisión por satélite u onda hertziana, periódicos y revistas se hacen eco de la enorme trascendencia del lenguaje cinematográfico buñueliano. Este estudio sobre la última de sus películas rodada en Andalucía, concretamente en Sevilla, pretende aportar un nuevo análisis sobre esta obra que trascendió el tópico andaluz.ABSTRACIn 1900 the film director Luis Buñuel is born in Calanda, Aragón. In 2000, it took place the centennial of his birth in different film and television environments in all over the world. The transcendency of film languaje used by Buñuel has been anlysed in cinema festivals, television, newspapers and magazines. This study, focus on his last movies filmed in Andalusia, concretely in Seville, it seeks to contribute with a new analysis on this work that transcended the Andalusian topic.
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Carlos Barreiro Ortiz
Full Text Available En el mes de julio de 19/37 el Cenro Colombo-Americano de Bogotá inició una serie de recitnles bajo el rótulo genérico de "Compositores colombianos del siglo XX". El objetivo del proyecto era la presentación sistemática de piezas de compositores nacionales menores de 35 años, como una manera de validar ante el público los primeros esbozos de una carrera profesional que se proyectaba con incertidumbre en un escenario cultural uadicionalista y cerrado a nuevas propuestns sonoras.
Brote de encefalitis de San Luis en el Área Metropolitana Buenos Aires Outbreack of St. Luis encephalitis in the Metropolitan Buenos Aires Area
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Alfredo Seijo
Full Text Available Se describen los hallazgos epidemiológicos y clínicos de 13 enfermos con diagnóstico de infección por virus de la encefalitis de San Luis, con transmisión entre enero y marzo de 2010, en el Area Metropolitana Buenos Aires (AMBA. Los 13 enfermos, promedio de edad 38 años, tuvieron un comienzo agudo caracterizado por hipertermia y cefalea. Entre los días dos y diez de iniciados los síntomas, 7/13 enfermos tuvieron signos y síntomas de compromiso neurológico caracterizado por meningitis sin signos encefálicos en 1/7. En 6/7 los hallazgos más frecuentes fueron: rigidez de nuca, desorientación temporoespacial, fotofobia, confusión y alteración del lenguaje. Dos resonancias magnéticas y un electroencefalograma presentaron signos de afectación de lóbulos temporales. El líquido cefalorraquídeo se caracterizó por pleocitosis con predominio de células mononucleadas, glucorraquia normal y discreto aumento de proteínas. No hubo casos fatales. En 6/13 pacientes la sospecha clínica inicial fue dengue. Por la agrupación espacial y temporal de los casos puede considerarse un brote epidémico, el primero conocido en el AMBA, ya que no se había notificado previamente la circulación epidémica del virus.We describe the epidemiological and clinical findings of 13 patients with diagnosis of infection by St. Louis encephalitis virus, transmitted between January and March 2010 in Buenos Aires Metropolitan Area (AMBA. Thirteen patients, average age 38 years, had an acute onset with hyperthermia and headache. Between days two and ten of the onset of symptoms, 7/13 patients had signs and symptoms of neurological involvement. This was characterized by meningitis without encephalic sings in 1/7 and in 6/7 the most frequent findings were: stiff neck, disorientation, photophobia, confusion and language impairment. Two MR and one EEG revealed signs of involvement of temporal lobes. The cerebrospinal fluid showed pleocytosis with predominance of
Observations on nests of Crocodylus moreletii in San Luis Potosí, Mexico Observaciones sobre nidos de Crocodylus moreletii en San Luis Potosí, México
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Armando H. Escobedo-Galván
Full Text Available Nesting ecology of Morelet's crocodile (Crocodylus moreletii has been documented since 1940. However, only 2 nests constructed on floating vegetation have been recorded. Here, we presented additional information from a mainland population of C. moreletii in the Ciénega de Cabezas wetland, San Luis Potosí, describing 2 nests constructed on floating mats of cattails. The nests were constructed using Typha sp., close to the main channel. One nest was lost due to flooding, and contained 32 eggs. Seven eggs had a mean 72.6 ± 2.63 mm length (range = 70.0 -75.0 mm, 45.0 ± 2.30 mm width (range = 41.0-48.0 mm, and 140.7 ± 2.98 mm diameter (range = 136.0-145.0 mm. We suggest that the use of floating vegetation for nesting by C. moreletii is related to the availability of aquatic vegetation, combined with the lack of adequate nesting sites on land.La ecología de anidación del cocodrilo de pantano (Crocodylus moreletii ha sido documentada desde 1940. Sin embargo, sólo existen 2 registros de nidos construidos sobre vegetación acuática. Presentamos información adicional de 2 nidos (N1 y N2 construidos en este tipo de hábitat en una población ubicada en la Ciénega de Cabezas en el estado de San Luis Potosí. Los nidos fueron construidos sobre Typha sp., cerca del cauce principal de la ciénega. El N2 se perdió por inundación, en su interior encontramos 32 huevos, los promedios (± SD del largo, ancho y diámetro de 7 huevos fueron 72.6 ± 2.63 mm (rango = 70.0 -75.0 mm, 45.0 ± 2.30 mm (rango = 41.0-48.0 mm, 140.7 ± 2.98 mm (rango = 136.0-145.0 mm, respectivamente. Sugerimos que este tipo de sitios para anidar por parte de C. moreletii está relacionado con la disponibilidad de vegetación acuática, combinado con la ausencia de sitios adecuados en tierra firme.
Luis Huerta: eugenesia, medicina y pedagogía en España Luis Huerta: Eugenics, Medicine and Pedagogy in Spain
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Luis Miguel LÁZARO LORENTE
Full Text Available En contraste con lo observable en la historiografía de otros países europeos y anglosajones, el estudio de la introducción y difusión de los principios y prácticas de la Eugenesia, como tema de investigación, no ha contado en España con muchos cultivadores. Menos todavía han sido objeto de estudio las relaciones del pensamiento eugénico con el ámbito pedagógico para indagar la recepción que tiene entre el Magisterio, y conocer el conjunto de reacciones que provoca, así como la participación de los maestros en la potencial difusión de sus planteamientos. Se aborda aquí una aproximación a ese tema centrando el análisis en las relaciones que en la España del primer tercio del siglo XX se establecen entre Medicina, Pedagogía y Eugenesia. Para ello tomamos como referente e hilo conductor la figura y el pensamiento del maestro asturiano Luis Huerta Naves, decidido impulsor y propagandista incansable de la Eugenesia en nuestro país.By comparison with the historiography of other European and Anglo-Saxon countries, the study of the origins and spread of Eugenics in Spain has not received much attention. Even less research has been done on the degree of acceptance of eugenic thought in the pedagogical domain or on the role teachers may have in the diffusion of eugenics. This paper attempts to explore the subject while focusing the analysis on the relations that were established among Medicine, Pedagogy and Eugenics in Spain during the first third of the 20th century. We will take as a point of reference and guiding line of thought the figure of the Asturian teacher Luis Huerta Naves, who was the driving force and tireless advocate of the eugenics movement in our country.
Knowledge discovery in the prediction of bankruptcy
Almeida, R.J.; Vieira, S.M.; Milea, D.V.; Kaymak, U.; Costa Sousa, da J.M.; Carvalho, J.P.; Dubois, D.; Kaymak, U.
Knowledge discovery in databases (KDD) is the process of discovering interesting knowledge from large amounts of data. However, real-world datasets have problems such as incompleteness, redundancy, inconsistency, noise, etc. All these problems affect the performance of data mining algorithms. Thus,
Máscaras de la lectura: Jorge Luis Borges en la obra de Mario Luzi / The masks of reading: Jeorge Luis Borges in Mario Luzi's work
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Daniel Clemente Del Percio
The roads that separate writers often end with a paradox, happy proximity. The nominations for the Nobel Prize for literature in 1979 came together, as in a real literary constellation, Italo Calvino, Alberto Moravia, Giorgio Bassani, Vittorio Sereni, Leonardo Sciascia and Mario Luzi, along with the argentine Jorge Luis Borges. The list reflects the richness and variety of Italian literature of the time. But beyond the storytellers, the coincidence of Luzi and Borges (and we might add, that of Odisseas Elytis, who was finally awarded the prize is a unique convergence of poets, with very different poetics, but with intense communicating vessels that unite them, often invisible and contradictory manner. While Borges never wrote about Luzi, the italian, however, did, and quite often, on the argentine, not only from the pages of literary criticism in «Il Corriere della Sera», space occupied until 1974 commenting Latin American literature (he has written about Roberto Arlt, Vargas Llosa and Juan Rulfo, among other writers, but in different interviews, where the frequent quotations that Luzi makes about Borges often installed a space for discussion and profound differences not only on the nature of poetry, but on the same link with the world and life. We propose to study these reflections that Mario Luzi made from (and on many occasions, against about the Argentine author, from the critical work of the Florentine poet, on the centenary of his birth.
Socratic Questioning-Guided Discovery
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M. Hakan Türkçapar
Full Text Available "Socratic Method" is a way of teaching philosophical thinking and knowledge by asking questions which was used by antique period greek philosopher Socrates. Socrates was teaching knowledge to his followers by asking questions and the conversation between them was named "Socratic Dialogues". In this meaning, no novel knowledge is taught to the individual but only what is formerly known is reminded and rediscovered. The form of socratic questioning which is used during the process of cognitive behavioral therapy is known as Guided Discovery. In this method it is aimed to make the client notice the piece of knowledge which he could notice but is not aware with a series of questions. Socratic method or guided discovery consists of several steps which are: Identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly found information and questioning the old distorted belief and reaching to a conclusion and applying it. Question types used during these procedures are, questions for gaining information, questions revealing the meanings, questions revealing the beliefs, questions about behaviours during the similar past experiences, analyse questions and analytic synthesis questions. In order to make the patient feel understood it is important to be empathetic and summarising the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues after eachstep. [JCBPR 2012; 1(1.000: 15-20
[Artificial Intelligence in Drug Discovery].
Fujiwara, Takeshi; Kamada, Mayumi; Okuno, Yasushi
According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI. In addition, with the aim of creating new therapeutic targets in genomic drug discovery, we have been also working on the development of a binding affinity prediction system for mutated proteins and drugs by molecular dynamics simulation using supercomputer "Kei". We also have tackled for problems in a drug virtual screening. Our developed AI technology has successfully generated virtual compound library, and deep learning method has enabled us to predict interaction between compound and target protein.
"Candidatus Rickettsia andeanae" en Amblyomma tigrinum, San Luis, Argentina
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Gabriel CICUTTIN
Full Text Available El objetivo del estudio fue detectar especies del género Rickettsia en garrapatas de la especie Amblyomma tigrinum colectadas sobre carnívoros domésticos y en sangre de caninos domésticos de la provincia de San Luis (Argentina. Entre 2013 y 2015 se colectaron 56 garrapatas adultas de la especie A. tigrinum sobre caninos y felinos domésticos, y se obtuvieron 65 muestras sanguíneas de caninos. Tres garrapatas resultaron positivas mediante la amplificación de un fragmento del espacio intergénico 23S-5S ARNr del género Rickettsia, lográndose secuenciar uno de los productos positivos. La muestra positiva secuenciada también resultó positiva por PCRs de los fragmentos de los genes gltA y ompA. Las secuencias obtenidas resultaron tener una identidad del 100 % de identidad con "Candidatus Rickettsia andeanae". Todas las muestras sanguíneas resultaron negativas. "Ca. R. andeanae" no ha sido asociada con enfermedad en humanos o animales, sin embargo, es necesario realizar nuevas investigaciones para lograr un mayor conocimiento del riesgo potencial de transmisión de rickettsiosis en la región. SUMMARY. "Candidatus Rickettsia andeanae" in Amblyomma tigrinum ticks from San Luis (Argentina. The aim of this study was to detect species of Rickettsia in Amblyomma tigrinum ticks collected from domestic carnivores and blood of domestic dogs of San Luis (Argentina. Between 2013 and 2015, 56 adults of A. tigrinum from dogs and cats and 65 blood from dogs were collected. Three ticks were positive by amplification of a 23S-5S rRNA fragment, and the sequence of one of the positive products was obtained. The positive sample sequenced was positive by PCRs of fragments of genes gltA and ompA. The sequences obtained were 100% identical with "Candidatus Rickettsia andeanae". All blood samples were negative. "Ca. R. andeanae" has not been associated with disease in humans or animals; however, further research is necessary to achieve greater
76 FR 414 - Tier 1 Environmental Impact Statement for the Los Angeles to San Luis Obispo (LOSSAN North) Rail...
... expected growth in population and resulting increases in intercity travel demand between Los Angeles and San Luis Obispo. As a result of this growth in travel demand, their travel delays from the growing... environmental analysis to help make corridor level decisions regarding the level of intercity passenger rail...
76 FR 39091 - San Luis Obispo Flood Control and Water Conservation District; Notice of Effectiveness of Surrender
... Flood Control and Water Conservation District; Notice of Effectiveness of Surrender On October 27, 1981... \\1\\ to the San Luis Obispo Flood Control and Water Conservation District (District) for the Lopez... and Water Conservation District, 17 FERC ] 62,113 (1981). On October 24, 2005, the District filed an...
Master Mentors: Linda Golian-Lui University of Hawaii-Hilo--George Oberle George Mason University, VA
Library Journal, 2005
Many movers and shakers inspire admiration and even awe, but those who inspire love are the mentors who have changed lives. That is why many grateful librarians nominated Linda Golian-Lui and George Oberle. Both of them were accidental librarians, work-study students whose supervisors encouraged them to become paraprofessionals, and then…
Diagnóstico etiológico de la ceguera de Jorge Luis Borges basado en su obra literaria
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Mario Enrique de la Piedra Walter
Conclusiones: Pese a que la miopía degenerativa es la etiología más probable de la ceguera de Jorge Luis Borges, no es posible descartar por completo otras oftalmopatías sin una exploración física adecuada. Se cumple el objetivo solo en el marco presuntivo.
Una aproximación al poema "Arte Poética" de Jorge Luis Borges
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Lorena Chaves Salgado
Full Text Available Este artículo presenta una lectura del poema 'Arte poética' de Jorge Luis Borges desarrollando aspectos teóricos relacionados con el análisis poético. El poema describe la labor del poeta y que significa escribir poesía, entendido para Borges como un acto y proceso creativo.
Innovations in Stream Restoration and Flood Control Design Meeting Flood Capacity and Environmental Goals on San Luis Obispo Creek
Wayne Peterson
Can a natural flowing creek be increased in drainage capacity to protect an adjacent community from flooding while still maintaining a natural habitat? San Luis Obispo constructed one such project on over a mile of Creek as a part of a housing development. The City found that some of the mitigation measures included in the project worked while others did not. In the...
More than Meets the Eye: Adult Education for Critical Consciousness in Luis Camnitzer's Art
Zorrilla, Ana Carlina
The purpose of this study was to explore the connection between art and adult education for critical consciousness through the conceptual art of Luis Camnitzer. The theoretical framework grounding this research was critical public pedagogy, influenced by both critical theory and Stuart Hall's systems of representation (1997). This framework…
Astroparticle physics: puzzles and discoveries
International Nuclear Information System (INIS)
Berezinsky, V
Puzzles often give birth to the great discoveries, the false discoveries sometimes stimulate the exiting ideas in theoretical physics. The historical examples of both are described in Introduction and in section 'Cosmological Puzzles'. From existing puzzles most attention is given to Ultra High Energy Cosmic Ray (UHECR) puzzle and to cosmological constant problem. The 40-years old UHECR problem consisted in absence of the sharp steepening in spectrum of extragalactic cosmic rays caused by interaction with CMB radiation. This steepening is known as Greisen-Zatsepin-Kuzmin (GZK) cutoff. It is demonstrated here that the features of interaction of cosmic ray protons with CMB are seen now in the spectrum in the form of the dip and beginning of the GZK cutoff. The most serious cosmological problem is caused by large vacuum energy of the known elementary-particle fields which exceeds at least by 45 orders of magnitude the cosmological vacuum energy. The various ideas put forward to solve this problem during last 40 years, have weaknesses and cannot be accepted as the final solution of this puzzle. The anthropic approach is discussed
Automated discovery systems and the inductivist controversy
Giza, Piotr
The paper explores possible influences that some developments in the field of branches of AI, called automated discovery and machine learning systems, might have upon some aspects of the old debate between Francis Bacon's inductivism and Karl Popper's falsificationism. Donald Gillies facetiously calls this controversy 'the duel of two English knights', and claims, after some analysis of historical cases of discovery, that Baconian induction had been used in science very rarely, or not at all, although he argues that the situation has changed with the advent of machine learning systems. (Some clarification of terms machine learning and automated discovery is required here. The key idea of machine learning is that, given data with associated outcomes, software can be trained to make those associations in future cases which typically amounts to inducing some rules from individual cases classified by the experts. Automated discovery (also called machine discovery) deals with uncovering new knowledge that is valuable for human beings, and its key idea is that discovery is like other intellectual tasks and that the general idea of heuristic search in problem spaces applies also to discovery tasks. However, since machine learning systems discover (very low-level) regularities in data, throughout this paper I use the generic term automated discovery for both kinds of systems. I will elaborate on this later on). Gillies's line of argument can be generalised: thanks to automated discovery systems, philosophers of science have at their disposal a new tool for empirically testing their philosophical hypotheses. Accordingly, in the paper, I will address the question, which of the two philosophical conceptions of scientific method is better vindicated in view of the successes and failures of systems developed within three major research programmes in the field: machine learning systems in the Turing tradition, normative theory of scientific discovery formulated by Herbert Simon
Geomorphic evolution of the San Luis Basin and Rio Grande in southern Colorado and northern New Mexico
Ruleman, Chester A.; Machette, Michael; Thompson, Ren A.; Miggins, Dan M; Goehring, Brent M; Paces, James B.
The San Luis Basin encompasses the largest structural and hydrologic basin of the Rio Grande rift. On this field trip, we will examine the timing of transition of the San Luis Basin from hydrologically closed, aggrading subbasins to a continuous fluvial system that eroded the basin, formed the Rio Grande gorge, and ultimately, integrated the Rio Grande from Colorado to the Gulf of Mexico. Waning Pleistocene neotectonic activity and onset of major glacial episodes, in particular Marine Isotope Stages 11–2 (~420–14 ka), induced basin fill, spillover, and erosion of the southern San Luis Basin. The combined use of new geologic mapping, fluvial geomorphology, reinterpreted surficial geology of the Taos Plateau, pedogenic relative dating studies, 3He surface exposure dating of basalts, and U-series dating of pedogenic carbonate supports a sequence of events wherein pluvial Lake Alamosa in the northern San Luis Basin overflowed, and began to drain to the south across the closed Sunshine Valley–Costilla Plain region ≤400 ka. By ~200 ka, erosion had cut through topographic highs at Ute Mountain and the Red River fault zone, and began deep-canyon incision across the southern San Luis Basin. Previous studies indicate that prior to 200 ka, the present Rio Grande terminated into a large bolson complex in the vicinity of El Paso, Texas, and systematic, headward erosional processes had subtly integrated discontinuously connected basins along the eastern flank of the Rio Grande rift and southern Rocky Mountains. We propose that the integration of the entire San Luis Basin into the Rio Grande drainage system (~400–200 ka) was the critical event in the formation of the modern Rio Grande, integrating hinterland basins of the Rio Grande rift from El Paso, Texas, north to the San Luis Basin with the Gulf of Mexico. This event dramatically affected basins southeast of El Paso, Texas, across the Chisos Mountains and southeastern Basin and Range province, including the Rio
Swordmanship as Mathematical Science: The Curious Case of Luis Pacheco de Narváez
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Felix Kurt Ernst Schmelzer
Full Text Available From the 15th century on, the practitioners of the mechanical arts obtain a new self-confidence and do no longer want to be regarded merely as manual workers. In this context, they frequently underline the mathematical basis of their discipline in order to increase its value from the status of a mechanical to that of a liberal art. In the Spanish golden age period, the military art, amongst others, is conceived as a mathematical discipline. A particularly curious case is the Libro de las grandezas de la espada (1600 whose author, Luis Pacheco de Narváez (1570-1640, propagates the art of swordsmanship, which he names «the true skill», as a science based on the disciplines of the quadrivium. The present article outlines the arguments applied by Pacheco in a preliminary chapter in order to prove the mathematical and scientific status of his discipline.
Presence of exotic birds in San Luis Potosi city, Mexican Plateau
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Ramírez-Albores, J.E.
Full Text Available We recorded 12 exotic bird species in San Luis Potosi, Mexico and adjacent areas. Obtained data were collected during the period August 2012 to August 2013. From the total of recorded species, eight are confirmations (Anas platyrhynchos domesticus, Cairina moschata, Bubulcus ibis, Columba livia, Sturnus vulgaris, Turdus rufopalliatus, Quiscalus mexicanus and Passer domesticus and four are new records (Aratinga canicularis, Amazona oratrix, A. autumnalis and Cyanocorax yncas. Although not all exotic species represent a risk because of the lack of the necessary resources for the establishment of abundant viable populations, it is important to publicize their status in the region. Therefore, knowing the presence of exotic species in a new distribution area is important for monitoring its establishment and colonization, and defining management, control and eradication programs of these species, along with environmental education programs that would lead to a better understanding of impacts that these species can cause.
FACCINI-MARTÍNEZ, Álvaro A.; BOTERO-GARCÍA, Carlos A.; HIDALGO, Marylin
Colombian physician Luis Benigno Patiño Camargo was one of the pioneers in the study of rickettsioses in South America, demonstrating for the first time in Colombia the presence of Rickettsia rickettsii as the etiological agent of a highly deadly exanthematic febrile syndrome in the 1930s. However, Patiño-Camargo performed other investigations from 1917-1943, which represent the first descriptions and scientific evidence of the presence of R. prowazekii and R. typhi in Colombia. Almost 60 years after the latest research conducted by Dr. Patiño-Camargo, rickettsioses were again a matter of interest and research. In the last decade over 20 research studies have been published, showing new endemic areas for R. rickettsii, as well as the description of new rickettsial species in Colombia. PMID:27074327
Los hongos poliporoides de la Huasteca Potosina, San Luis Potosí, México
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Victor I. Alvarez
Full Text Available Se estudiaron 98 especies de hongos poliporoides basados en 358 especímenes procedentes de 15 localidades de nueve municipios de la Huasteca Potosina en el estado de San Luis Potosí. Las 98 especies se clasifican en tres órdenes de Agaricomycetes, el orden Gloeophyllales con una familia, un género y una especie, el orden Hymenochaetales con 2 familias, 10 géneros y 33 especies, y el orden Polyporales con seis familias, 32 géneros y 64 especies. De éstas, 73 se citan por primera vez para el estado, incluidas Phellinus calcitratus, P. coffeatoporus y Ceriporia reticulata que son nuevos registros para México.Palabras clave: Gloeophyllales, Hymenochaetales, Polyporales, macrohongos xilófagos.
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Victor Dordio
Full Text Available José Luis Andrés Sarasa y su equipo de investigadores de la Universidad de Murcia hizo un excelente análisis estructural de la producción de vino en la Región de Murcia en el marco del proyecto «Filières Innovantes» (2002-2005. Los temas del espacio y tiempo, la tipología de los productores, bajo la óptica del savoir-faire, han sido minuciosamente estudiados y presentados. Nuestra contribución a este estudio consistió en un capítulo sobre el turismo del vino, que no se trató anteriormente debido a la falta de tiempo.
Survey of the University "Luis Vargas Torres" through Econometric Techniques. Comprehensive Income
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Ramón Rodríguez-Betancourt
Full Text Available Government Programme 2013-2017 defines in higher education, the principles of the curriculum proposals of much public interest careers. In this regard the authorities of the Technical University "Luis Vargas Torres" of Esmeraldas, have taken the decision to evaluate its management and action against the development of the province and the country. Therefore, the objective of this research is the application of a survey of students of different specialties, Faculty of Engineering and Technology to explore their views on the educational process, research, outreach, culture and sport, stratified random sampling with results showing that key processes are completed by 66% on average is applied, indicating that the authority still has to set goals to overcome the short comings that have an emphasis on research.
The Outreach Process in the Technical University Luis Vargas Torres, Esmeraldas, Ecuador
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Harold Oyarvide-Ramirez
Full Text Available As part of the transformative process that takes place in the ecuadorian university is research that aims to improve the outreach model at the Technical University Luis Vargas Torres Esmeraldas developed. The need of jobs forces people to venture into small businesses, however, this process is done in an empirical way, without sufficient technical and administrative knowledge that will enable the company to manage efficiently and obtain funding sources. Hence the relevance of the study, which allows guide and train the business sector in order to conduct an efficient management and create new businesses that operate as a means for the transformation of the productive matrix. The research results are: the structure and function of outreach model, the key elements that support the creation of the Center for Business Development and Entrepreneurship Support and the socioeconomic impact achieved from the development of relations among universities, businesses and government.
Saber mirar, saber contar. La narrativa cinematográfica de José Luis Borau
Mérida Donoso, José Antonio
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Filosofía y Letras, Departamento de Filología Española. Fecha de lectura: 29-9-2017 La presente tesis doctoral se adentra en una de las figuras fundamentales de la historia del cine español, José Luis Borau. Para ello se analiza su cine desde una perspectiva textual, atendiendo al emisor, el receptor, el contexto –de producción y sociopolítico- y el texto fílmico. Bajo este prisma se ofrece una visión del estilo...
Luis Álvarez-Gaumé to speak at El Ser Creativo 2011
Jordan Juras
During the weekend of 19 October, 2011, Madrid will host this year's El Ser Creativo – a three-day conference celebrating new ideas that can change the world. Over the course of the conference, 21 speakers will have the chance to share their opinions and ideas for 21 minutes each – the estimated time that the human brain is able to maintain complete focus. Among the Nobel Prize winners, scientists, doctors, and thinkers invited to this year's conference is Luis Álvarez-Gaumé, a theoretical physicist at CERN. Having made significant contributions to the understanding of gravitation, minimal supergravity theory and supersymmetry, Álvarez-Gaumé was an obvious choice to be invited to share his thoughts about the theory and reality of current physics ideas with the conference attendees. A webcast will be available to stream the entire conference live.
Un precedente de psicología conductual en la Universidad Nacional de San Luis (Argentina)
Calabresi, Corina; Polanco, Fernando
En 1970 un grupo de estudiantes de la Licenciatura en Psicología y Pedagogía de la Universidad Nacional de San Luis, Argentina, tuvo un activo compromiso con el desarrollo de una psicología científica basada en la teoría conductual. El trabajo analiza la conformación de dicho movimiento estudiantil y la fundación, por parte del mismo, en 1974 del Centro de Estudios de Psicología Objetiva I. P. Pavlov (CEDEPO), el cual progresivamente cuestionó la hegemonía psicoanalítica en el medio académico...
Masculinidad y violencia en el nuevo cine mexicano. Las películas de Luis Estrada
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Claudia Elizabeth Puente
Full Text Available En este artículo exploraremos la conformación de las masculinidades a través de las representaciones cinematográficas en América latina, específicamente en la obra del mexicano Luis Estrada, parte fundamental del llamado Nuevo cine mexicano en sus obras exhibidas entre 1999 y 2010. Aunque el universo de estudios de masculinidades es cada vez más amplio, las representaciones cinematográficas no han sidomuy exploradas. Este artículo pretende hacer un análisis de las representaciones masculinas y su relación con las representaciones femeninas en el nuevo cine mexicano en un contexto de violencia desde una perspectiva crítica feminista.
Geology and petrography of basement in south extreme in Sierra Grande de San Luis, Argentina
International Nuclear Information System (INIS)
Morosini, A.; Ortiz Suarez, A.
In the south of the Sierra de San Luis is recognized a basement composed by La Escalerilla and Los Puquios granites, accompanied by schist, mylonite s and mafic-ultramafic rocks. The schists, La Escalerilla granite and the mafic -ultramafic rocks are affected by a regional metamorphism in anphibolites facies, the two first present a N-S foliation di ping to east. The mylonite s correspond to a second event of deformation, distributed in thin belts of NNE-SSO direction and inclination to east, developed in green schist to anphibolites facies. Los Puquios granite represents the more young of the basement rocks and the intrusion was associated with a shear zone. Los Puquios granite forms dikes and small plutons cutting La Escalerilla granite and micas chits in high cortical levels
Offshore geology and geomorphology from Point Piedras Blancas to Pismo Beach, San Luis Obispo County, California
Watt, Janet Tilden; Johnson, Samuel Y.; Hartwell, Stephen R.; Roberts, Michelle
Marine geology and geomorphology were mapped along the continental shelf and upper slope between Point Piedras Blancas and Pismo Beach, California. The map area is divided into the following three (smaller) map areas, listed from north to south: San Simeon, Morro Bay, and Point San Luis. Each smaller map area consists of a geologic map and the corresponding geophysical data that support the geologic mapping. Each geophysical data sheet includes shaded-relief multibeam bathymetry, seismic-reflection-survey tracklines, and residual magnetic anomalies, as well as a smaller version of the geologic map for reference. Offshore geologic units were delineated on the basis of integrated analysis of adjacent onshore geology, seafloor-sediment and rock samples, multibeam bathymetry and backscatter imagery, magnetic data, and high-resolution seismic-reflection profiles. Although the geologic maps are presented here at 1:35,000 scale, map interpretation was conducted at scales of between 1:6,000 and 1:12,000.
The archaeological investigations of 1984 at Trinca "Izvorul lui Luca" site
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Oleg Leviţki
Full Text Available The article presents the archaeological researches carried out at Trinca "Izvorul lui Luca" settlement in 1984. The paper is part of the series of articles initiated by the authors in order to include the research results of this unusual site. The discovered archaeological remains were treated in a complex way, presented on layers, complexes, categories and types. Thus, the discovered complexes were described, the pieces of inventory systematized according to the categories of materials from which they were made, while the ceramics is presented by categories, types and variants. The most relevant findings have been analysed in more detail, being related to those specific of other synchronous or partially synchronic neighbouring cultures. As a result, the existence of a set of artefacts has been established, having analogies in the Hallstattian Carpathian-Nistrian cultural environment and, respectively, in the Middle Danube area.
Mineralogy of auriferous deposits of the quaternary deposits in the San Luis Province, Argentina
International Nuclear Information System (INIS)
Karlsson, A.; Ayala, R. . E mail: firstname.lastname@example.com
The objective of this work is to study the mineralogy of the sands and clays of the quaternary deposits in the San Luis Mountain, Argentina. A series of algorithms applied to the sand fraction has permitted to determine sedimentary discontinuities. The two micron fraction of the sediments has been studied by a quantification technique based on X-ray diffraction by means of oriented preparations and run with copper tube. These quaternary silts have received fluvial lateral contributions. The high cristalinidad of non expandibles and fireclay clay show the antique of the silts. The polygenic processes have generated a great variety of clay mineral species like a large quantities of illite and in lesser extend kaolinite and smectites. The illite was probably generated by diagenetic changes. The high cristalinidad of non expandibles and fireclay clay show the antique of the silts [es
Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.
Service discovery is a fady new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between deviies. This paper provides an ovewiew and comparison of several prominent
Academic Drug Discovery Centres
DEFF Research Database (Denmark)
Kirkegaard, Henriette Schultz; Valentin, Finn
Academic drug discovery centres (ADDCs) are seen as one of the solutions to fill the innovation gap in early drug discovery, which has proven challenging for previous organisational models. Prior studies of ADDCs have identified the need to analyse them from the angle of their economic...
For the past two-and-a-half decades, the Office of Science at the U.S. Department of Energy has been at the forefront of scientific discovery. Over 100 important discoveries supported by the Office of Science are represented in this document.
Sundramoorthy, V.; Scholten, Johan; Jansen, P.G.; Hartel, Pieter H.
Service discovery is a fairly new field that kicked off since the advent of ubiquitous computing and has been found essential in the making of intelligent networks by implementing automated discovery and remote control between devices. This paper provides an overview and comparison of several
Hydrogeologic Assessment of the East Bear Creek Unit, San LuisNational Wildlife Refuge
Energy Technology Data Exchange (ETDEWEB)
Quinn, Nigel W.T.
San Luis National Wildlife Refuge Complex to meetReclamation s obligations for Level 4 water supply under the CentralValley Project Improvement Act. Hydrogeological assessment of the EastBear Creek Unit of the San Luis National Wildlife Refuge was conductedusing a combination of field investigations and a survey of availableliterature from past US Geological Survey Reports and reports by localgeological consultants. Conservative safe yield estimates made using theavailable data show that the East Bear Creek Unit may have sufficientgroundwater resources in the shallow groundwater aquifer to meet aboutbetween 25 percent and 52 percent of its current Level II and between 17percent and 35 percent of its level IV water supply needs. The rate ofsurface and lateral recharge to the Unit and the design of the well fieldand the layout and capacity of pumped wells will decide both thepercentage of annual needs that the shallow aquifer can supply andwhether this yield is sustainable without affecting long-term aquiferquality. In order to further investigate the merits of pumping the nearsurface aquifer, which appears to have reasonable water quality for usewithin the East Bear Creek Unit -- monitoring of the potential sources ofaquifer recharge and the installation of a pilot shallow well would bewarranted. Simple monitoring stations could be installed both upstreamand downstream of both the San Joaquin River and Bear Creek and beinstrumented to measureriver stage, flow and electrical conductivity.Ideally this would be done in conjunction with a shallow pilot well,pumped to supply a portion of the Unit's needs for the wetland inundationperiod.
1959: los intentos de derrocamiento de las dictaduras de Trujillo, Stroessner y Luis Somoza
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María Dolores Ferrero Blanco
Full Text Available El triunfo de la revolución cubana trajo, entre sus múltiples consecuencias, la reanimación de la oposición a las tres dictaduras fuertes en 1959: la República Dominicana, Nicaragua y Paraguay. En el presente artículo se analizan las características generales de las mismas, los paralelismos y diferencias entre Trujillo, Stroessner y Somoza, al tiempo que se exponen los diversos intentos de los opositores exiliados para acabar con los regímenes tiránicos implantados en sus respectivos países. Las fuentes utilizadas proceden de los archivos nacionales y de relaciones exteriores, especialmente la documentación diplomática, que aporta una visión singular de los embajadores dependiendo de los destinos. Palabras clave: Rafael Leónidas Trujillo, Luis Somoza, Alfredo Stroessner, dictaduras iberoamericanas, revolución cubana, oposición a las dictaduras._______________________________Abstract: Cuban revolution success brought, among its multiple consequences, the liveliness of the political opposition against the three dictatorships in 1959: the Dominican Republic, Nicaragua and Paraguay. In the present article it is analyzed their general characteristics of the same ones, the differences between Trujillo, Stroessner and the Somoza's, as same as it is exposed the several attempts of the exiles op-ponents to end the implanted tyrannies' regimes in their respective countries. The sources used come from the national archives and foreign relations, especially the diplomatic docu-mentation, that contributes with a singular vision of the ambassadors depending on their destinies, an optics that serves us to know the relations established between the three dictators.Keywords: Rafael Leónidas Trujillo, Luis Somoza, Alfredo Stroessner, latinoamerican dictatorships, Cuban Revolution, dictatorships political opposition.
Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México
Background Although epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis (TB) control in Mexico, molecular epidemiology studies of the disease in the country are scarce. Methods Complete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB (PTB) cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex (MTC) isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined. Results Pulmonary tuberculosis incidence ranged from 2.4 to 33.4 (cases per 100,000 inhabitants) in the six state sanitary jurisdictions that were grouped in regions of low (jurisdictions I-II-III), intermediate (jurisdictions IV-V) and high incidence (jurisdiction VI) with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis (104 spoligotypes in 24 clusters) and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage (Beijing family) in the capital city, the Indo-Oceanic (Manila family) in eastern localities, and M. bovis in rural localities. Conclusions In San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage. PMID:23635381
Genetic diversity of the Mycobacterium tuberculosis complex in San Luis Potosí, México.
López-Rocha, Estela; Juárez-Álvarez, Julio; Riego-Ruiz, Lina; Enciso-Moreno, Leonor; Ortega-Aguilar, Francisco; Hernández-Nieto, Julián; Enciso-Moreno, José A; López-Revilla, Rubén
Although epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis (TB) control in Mexico, molecular epidemiology studies of the disease in the country are scarce. Complete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB (PTB) cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex (MTC) isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined. Pulmonary tuberculosis incidence ranged from 2.4 to 33.4 (cases per 100,000 inhabitants) in the six state sanitary jurisdictions that were grouped in regions of low (jurisdictions I-II-III), intermediate (jurisdictions IV-V) and high incidence (jurisdiction VI) with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis (104 spoligotypes in 24 clusters) and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage (Beijing family) in the capital city, the Indo-Oceanic (Manila family) in eastern localities, and M. bovis in rural localities. In San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage.
"Eureka, Eureka!" Discoveries in Science
Agarwal, Pankaj
Accidental discoveries have been of significant value in the progress of science. Although accidental discoveries are more common in pharmacology and chemistry, other branches of science have also benefited from such discoveries. While most discoveries are the result of persistent research, famous accidental discoveries provide a fascinating…
Escrituras, hurtos y reelaboraciones de Luis Hurtado de Toledo (1523-1590): edición de su obra literaria y estudio de su obra impresa
Gamba Corradine, Jimena
[ES] La tesis doctoral «Escrituras, hurtos y reelaboraciones de Luis Hurtado de Toledo (1523-1590): edición de su obra literaria y estudio de su obra impresa» consiste en la edición de una parte del corpus literario adjudicado a Luis Hurtado de Toledo. Se editan aquí, con notas al texto, los romances en pliego resguardados en RM 259 + [260] (Romance de las notables cosas que tiene la imperial ciudad de Toledo), RM 261 + [261] y 263 (Romance nuevamente hecho por Luis Hurtado, en el qual se co...
Semantic Service Discovery Techniques for the composable web
Fernández Villamor, José Ignacio
This PhD thesis contributes to the problem of resource and service discovery in the context of the composable web. In the current web, mashup technologies allow developers reusing services and contents to build new web applications. However, developers face a problem of information flood when searching for appropriate services or resources for their combination. To contribute to overcoming this problem, a framework is defined for the discovery of services and resources. In this framework, thr...
The Greatest Mathematical Discovery?
Energy Technology Data Exchange (ETDEWEB)
Bailey, David H.; Borwein, Jonathan M.
What mathematical discovery more than 1500 years ago: (1) Is one of the greatest, if not the greatest, single discovery in the field of mathematics? (2) Involved three subtle ideas that eluded the greatest minds of antiquity, even geniuses such as Archimedes? (3) Was fiercely resisted in Europe for hundreds of years after its discovery? (4) Even today, in historical treatments of mathematics, is often dismissed with scant mention, or else is ascribed to the wrong source? Answer: Our modern system of positional decimal notation with zero, together with the basic arithmetic computational schemes, which were discovered in India about 500 CE.
Discovery of the neutron (to the fiftieth anniversary of neutron discovery)
International Nuclear Information System (INIS)
Pasechnik, M.V.
Development of neutron physics in the USSR for the recent 50 years from the moment of neutron discovery is considered. History of neutron discovery is presented in brief. Neutron properties and fundamental problems of physics: electric dipole neutron moment, neutron β-decay, neutron interaction with nuclei and potential of nucleon interaction not conserving spatial parity are discussed. Main aspects of neutron physics application in power engineering, nuclear technology and other branches of science and technique are set forth
Literature-related discovery techniques applied to ocular disease : a vitreous restoration example
Kostoff, Ronald N.; Los, Leonoor I.
Purpose of reviewLiterature-related discovery and innovation (LRDI) is a text mining approach for bridging unconnected disciplines to hypothesize radical discovery. Application to medical problems involves identifying key disease symptoms, and identifying causes and treatments for those symptoms
Multidimensional process discovery
Ribeiro, J.T.S.
Typically represented in event logs, business process data describe the execution of process events over time. Business process intelligence (BPI) techniques such as process mining can be applied to get strategic insight into business processes. Process discovery, conformance checking and
Fateful discovery almost forgotten
"The discovery of the fission of uranium exactly half a century ago is at risk of passing unremarked because of the general ambivalence towards the consequences of this development. Can that be wise?" (4 pages)
Harvey, Alan L
Components from venoms have stimulated many drug discovery projects, with some notable successes. These are briefly reviewed, from captopril to ziconotide. However, there have been many more disappointments on the road from toxin discovery to approval of a new medicine. Drug discovery and development is an inherently risky business, and the main causes of failure during development programmes are outlined in order to highlight steps that might be taken to increase the chances of success with toxin-based drug discovery. These include having a clear focus on unmet therapeutic needs, concentrating on targets that are well-validated in terms of their relevance to the disease in question, making use of phenotypic screening rather than molecular-based assays, and working with development partners with the resources required for the long and expensive development process. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.
Defining Creativity with Discovery
Wilson, Nicholas Charles; Martin, Lee
The standard definition of creativity has enabled significant empirical and theoretical advances, yet contains philosophical conundrums concerning the nature of novelty and the role of recognition and values. In this work we offer an act of conceptual valeting that addresses these issues and in doing so, argue that creativity definitions can be extended through the use of discovery. Drawing on dispositional realist philosophy we outline why adding the discovery and bringing into being of new ...
International Nuclear Information System (INIS)
Piccioni, O.
The author of this article describes his own role in the discovery of the antiproton. Although Segre and Chamberlain received the Nobel Prize in 1959 for its discovery, the author claims that their experimental method was his idea which he communicated to them informally in December 1954. He describes how his application for citizenship (he was Italian), and other scientists' manipulation, prevented him from being at Berkeley to work on the experiment himself. (UK)
DEFF Research Database (Denmark)
Bukh, Per Nikolaj
Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august......Anmeldelse af Discovery Driven Growh : A breakthrough process to reduce risk and seize opportunity, af Rita G. McGrath & Ian C. MacMillan, Boston: Harvard Business Press. Udgivelsesdato: 14 august...
International Nuclear Information System (INIS)
Fowler, P.H.
The paper traces the discovery of the Π meson. The discovery was made by exposure of nuclear emulsions to cosmic radiation at high altitudes, with subsequent scanning of the emulsions for meson tracks. Disintegration of nuclei by a negative meson, and the decay of a Π meson were both observed. Further measurements revealed the mass of the meson. The studies carried out on the origin of the Π-mesons, and their mode of decay, are both described. (U.K.)
Guided Discovery with Socratic Questioning
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M. Hakan Türkçapar
Full Text Available The Socratic method is a way of teaching philosophical thinking and knowledge by asking questions. It was first used by in ancient times by the Greek philosopher Socrates who taught his followers by asking questions; these conversations between them are known as Socratic dialogues. In this methodology, no new knowledge is taught to the individual; rather, the individual is guided to remember and rediscover what was formerly known through this process. The main method used in cognitive therapy is guided discovery. There are various methods of guided discovery in cognitive therapy. The form of verbal exchange between the therapist and client which is used during the process of cognitive behavioral therapy is known as socratic questioning. In this method the goal is to make the client rediscover, with a series of questions, a piece of knowledge which he could otherwise know but is not presently conscious of. The Socratic Questioning consists of several steps, including: identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly rediscovered information and questioning the old distorted belief, and reaching a new conclusion and applying it. Question types used during these procedures are: questions for collecting information, questions revealing meanings, questions revealing beliefs, questions about behaviours during similar past experiences, analytic questions and analytic synthesis questions. In order to make the patient feel understood, it is important to be empathetic and summarize the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues provided for each step. [JCBPR 2015; 4(1.000: 47-53
Provencance of the late Proterozoic to early Cambrian metaclastic sediments ot the Sierra de San Luis (Eastern Sierras Pampeanas) and Cordillera Oriental, Argentina
DEFF Research Database (Denmark)
Drobe, M.; López de Luchi, M.; Steenken, A.
Provenance studies have been performed utilising major and trace elements, Nd systematics, whole rock Pb-Pb isotopes and zircon U/Pb SHRIMP data on metasedimentary rocks of the Sierra de San Luis (Nogolí Metamorphic Complex, Pringles Metamorphic Complex, Conlara Metamorphic Complex and San Luis...... is depicted for all the complexes using major and trace elements. The Pringles Metamorphic Complex shows indications for crustal recycling, pointing to a bimodal provenance. Major volcanic input has to be rejected due to Th/Sc, Y/Ni and Cr/V ratios for all units. The eNd(540 Ma) data is lower for the San Luis...... Formation and higher for the Conlara Metamorphic Complex, as compared to the other units, in which a good consistency is given. This is similar to the TDM ages, where the metapsammitic samples of the San Luis Formation are slightly older. The spread of data is largest for the Pringles Metamorphic Complex...
Introduction to the Special Collection of Papers on the San Luis Basin Sustainability Metrics Project: A Methodology for Evaluating Regional Sustainability
This paper introduces a collection of four articles describing the San Luis Basin Sustainability Metrics Project. The Project developed a methodology for evaluating regional sustainability. This introduction provides the necessary background information for the project, descripti...
Expansão espacial da leishmaniose visceral americana em São Luis, Maranhão, Brasil Space expansion of the American visceral leishmaniasis in São Luis, Maranhão, Brazil
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Wellington da Silva Mendes
Full Text Available Descreve-se a ocupação espacial no município de São Luis e a expansão da leishmaniose visceral americana(LVA na mesma. Foram analisadas as fichas de registro de atendimento de casos de leishmaniose visceral da Diretoria Regional da Fundação Nacional de Saúde do Maranhão no período de setembro de 1982 a dezembro de 1996, assim como documentos oficiais sobre a ocupação espacial do município. Foi observado que os casos de LVA ao longo da evolução da epidemia em São Luis apresentaram distribuição espacial e concentração semelhantes a apresentada pelo fluxo migratório na cidade no mesmo período.The space occupation and the expansion of American visceral leishmaniasis (AVL were described in the municipality of São Luis, Maranhão, Northeast Brazil. AVL medical notes from the Fundação Nacional de Saúde as well as official documents about the space occupation were analyzed from September 1982 to December 1996. AVL cases were more likely to occur in recently settled suburbs and tended to follow the same spatial pattern observed for land occupations secondary to migratory fluxes.
Specificity of discoveries in radiochemistry
International Nuclear Information System (INIS)
Krivomazov, A.N.
The development of radiochemistry as a science is elucidated. On the basis of original papers and archives materials which have become available only recently, specific features of opening the law of radioactive displacements and isotopy of radioactive elements are presented in detail. A contribution of Hevesy, Russel, Fajans, and Soddy into the solution of this problem is considered; an important role of Rutherford in putting down the priority conflict is shown. Two stages of scientific generalization are singled out in the history of opening the law of radioactive displacements: the stage of the rules and the stage of the laws. On this basis the solutions of the priority problems have been reconsidered. It is shown that the history of radiochemistry is rich in discoveries which have undergone a relatively long evolution
Ampliación de la distribución de Physalaemus biligonigerus (Cope, 1860 (Anura: Leiuperidae en la provincia de San Luis, Argentina
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Moreno, Liliana
Full Text Available República Argentina, San Luis, Departamento Gral. Pedernera, Villa Mercedes (33º42'18,71" S 66º26'27,98" W. Fecha de colección: 29/XII/ 2006. Col: R. Gutierrez y L. Moreno. Los ejemplares están depositados en la Colección Herpetológica de la Universidad Nacional de San Luis (CH-UNSL 0389 – CH-UNSL 0390.
Transient Electromagnetic Soundings Near Great Sand Dunes National Park and Preserve, San Luis Valley, Colorado (2006 Field Season)
Fitterman, David V.; de Sozua Filho, Oderson A.
Time-domain electromagnetic (TEM) soundings were made near Great Sand Dunes National Park and Preserve in the San Luis Valley of southern Colorado to obtain subsurface information of use to hydrologic modeling. Seventeen soundings were made to the east and north of the sand dunes. Using a small loop TEM system, maximum exploration depths of about 75 to 150 m were obtained. In general, layered earth interpretations of the data found that resistivity decreases with depth. Comparison of soundings with geologic logs from nearby wells found that zones logged as having increased clay content usually corresponded with a significant resistivity decrease in the TEM determined model. This result supports the use of TEM soundings to map the location of the top of the clay unit deposited at the bottom of the ancient Lake Alamosa that filled the San Luis Valley from Pliocene to middle Pleistocene time.
Visual Resource Analysis for Solar Energy Zones in the San Luis Valley
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Sullivan, Robert [Argonne National Laboratory (ANL), Argonne, IL (United States). Environmental Science Division; Abplanalp, Jennifer M. [Argonne National Laboratory (ANL), Argonne, IL (United States). Environmental Science Division; Zvolanek, Emily [Argonne National Laboratory (ANL), Argonne, IL (United States). Environmental Science Division; Brown, Jeffery [Bureau of Land Management, Washington, DC (United States). Dept. of the Interior
This report summarizes the results of a study conducted by Argonne National Laboratory's (Argonne's) Environmental Science Division for the U.S. Department of the Interior Bureau of Land Management (BLM). The study analyzed the regional effects of potential visual impacts of solar energy development on three BLM-designated solar energy zones (SEZs) in the San Luis Valley (SLV) in Colorado, and, based on the analysis, made recommendations for or against regional compensatory mitigation to compensate residents and other stakeholders for the potential visual impacts to the SEZs. The analysis was conducted as part of the solar regional mitigation strategy (SRMS) task conducted by BLM Colorado with assistance from Argonne. Two separate analyses were performed. The first analysis, referred to as the VSA Analysis, analyzed the potential visual impacts of solar energy development in the SEZs on nearby visually sensitive areas (VSAs), and, based on the impact analyses, made recommendations for or against regional compensatory mitigation. VSAs are locations for which some type of visual sensitivity has been identified, either because the location is an area of high scenic value or because it is a location from which people view the surrounding landscape and attach some level of importance or sensitivity to what is seen from the location. The VSA analysis included both BLM-administered lands in Colorado and in the Taos FO in New Mexico. The second analysis, referred to as the SEZ Analysis, used BLM visual resource inventory (VRI) and other data on visual resources in the former Saguache and La Jara Field Offices (FOs), now contained within the San Luis Valley FO (SLFO), to determine whether the changes in scenic values that would result from the development of utility-scale solar energy facilities in the SEZs would affect the quality and quantity of valued scenic resources in the SLV region as a whole. If the regional effects were judged to be significant, regional
[Physical factors influencing the floristic relationships of pinyon pine (Pinaceae) from San Luis Potosi, Mexico].
Romero, Angélica; Luna, Mario; García, Edmundo
In plant communities, the species distribution patterns and their relationships with environmental factors are of central importance in ecology. In San Luis Potosí of Mexico, woodlands of Pinus cembroides and P. johannis are sympatric, but P. cembroides tends to be located in South and Southwest slopes, in more disturbed sites; unlike, P. johannis, is mostly distributed in mesic areas, in North and Northeast slopes. The aim of this study was to analyze the influence of some physical factors on the floristic similarity of pinyon pine P. cembroides and P. johannis. The study area was located in the Sierra San Miguelito, San Luis Potosí, Mexico. We selected 40 sampling units spread over an area of 50km2. In each unit, we laid out two 20m long lines perpendicular to each other, in which we recorded cover data of the plant species intercepted. We developed two data matrices, the first one including cover values of 91 species, and the second one, considering seven topographical, climatic, and solar radiation variables. We applied cluster analysis and ordination to explore the influence of environmental variables on the floristic differentiation of pinyon pine woodlands. Clustering showed six groups, the first three characterized by P. cembroides. The ordination showed that variance represented by the first three axes was 65.9%. Axis 1 was positively correlated with altitude and negatively with mean annual temperature; axes two and three, showed low correlation with the variables tested. P. cembroides woodlands and accompanying flora tend to be located in lower altitude, higher mean annual temperature, and mainly in South-Southwestern slopes. In contrast, stands of P. johannis, mixed stands of P. johannis-P. cembroides, and Quercus potosina, were usually founded in greater altitudes, mean annual temperature slightly lower, and North-Northeastern exposure. The sites of these monospecific and mixed woodlands with associated species, indicators of environmental variables
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Alexandru MAZILU
Full Text Available Ideile lui Rousseau au avut un impact major asupra societăţii la sfârşitul sec. al XVIII-lea şi pe parcursul întregii perioade a sec. al XIX-lea. Aceste idei au imprimat un suflu modern cugetului său, fiind considerat şi un ideologist politic, o voce puternică a Revoluţiei Franceze şi un pioner al curentului romantic. În legătură cu domeniul nostru de studiu, paradoxurile concepţiei politice ale lui Rousseau se referă la contradicţia dintre aspiraţiile modernităţii şi criticile violente ale progresului social. El pune accentul pe contradicţia dintre încrede-rea deplină în ,,contractul social", ca pattern cultural şi lipsa de încredere în ,,educaţia socială". Unicul mod de a depăşi aceste contradicţii este abordarea noului model al filosofiei educaţiei bazat pe reforme radicale pentru a facilita autodezvoltarea individului. THE PARADOXES OF POLITICAL CONCEPTION IN THE WORK OF JEAN-JACQUES ROUSSEAUHis ideas have a big impact on the society at the end of the 18th century and the whole 19th century period. These ideas transform his spirit into a modern one, as well as a political ideologist, main voice of the French Revolution and pioneer of the Romantic Movement. Related to our article subject, Rousseau's political conceptual paradoxes refer to the contradiction between moderni-ty aspiration and the violent critic of the social progress. He emphasizes the contradiction between full trust of the "social contract", as a cultural pattern and the distrust of the "social education." The only way to leave the contradictions behind is his new education philosophy pattern based on a radical reform in order for the individual to develop himself.
Luis Moya y las bóvedas tabicadas en la posguerra española
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Adell, Josep Mª
Full Text Available In the precarious economic conditions prevailing after the Spanish Civil War, tiled vault construction was resumed to economize on steel and capitalize on the cheap labour available at the time.
Luis Moya excelled in this area, re-exploring this construction technique. Moya benefited in this regard from his thorough knowledge of the early twentieth century works of the Guastavinos in New York acquired during his visits to the U.S.A. with Professor Collins.
His architecture featured tiled vaults with medium-sized spans, normally reinforced with exposed internal Basque tiled arches or ribbing on the extrados.
He described his architectural experimentation in this field in a book titled "Bóvedas tabicadas" (tile vaults, one of the few extensive treatises on the subject, which surpassed the papers published earlier by Fornés-Gurrea and Bergós.
Después de la Guerra Civil, y ante la precaria situación económica del pais, se volvió a retomar en España, la construcción tabicada como medio de encomizar acero en la edificación, y aprovechando la mano de obra barata del momento.
Luis Moya destacó en este aspecto, reinvestigando sobre la construcción tabicada siendo perfectamente conocedor de la obra de los Guastavino en Nueva York, de principios de siglo, por sus visitas realizadas acompañadas del Profesor Collins a EEUU.
La arquitectura de Moya destacó por aplicar soluciones de bóvedas tabicadas de mediana luz que normalmente reforzaba empleando arcos tabicados internos vistos, o bien acostillando las bóvedas por sus trasdós.
Esta labor arquitectónica basada en su propia experimentación constructiva, la publicó en el libro "Bóvedas Tabicadas", siendo uno de los pocos tratados amplios sobre este tema existente, superando con él a lo publicado por Fornés-Gurrea y Bergós con anterioridad.
Una aproximación al poema "Arte Poética" de Jorge Luis Borges
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Lorena Chaves Salgado
Full Text Available Este artículo presenta una lectura del poema 'Arte poética' de Jorge Luis Borges desarrollando aspectos teóricos relacionados con el análisis poético. El poema describe la labor del poeta y qué significa escribir poesía, entendido para Borges como un acto y proceso creativo.
Contradictions porteñas: modernity, modernism and modernization in Jorge Luis Borges during the 1920's
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Pedro Demenech
Full Text Available The aim of the article is discuss the concepts of modernity, modernism and modernization from the propositions raised by Marshal Berman and Néstor García Canclini. The fierce transformation of Buenos Aires during the 1920's will be the focus of the analysis. To this end, we use the work of argentine poet Jorge Luis Borges to comprehend the development of these processes in the urban space of Buenos Aires.
El modelo ideal de interactividad es la conversación. Entrevista a José Luis Orihuela
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Juan Salvador Victoria Mas
Full Text Available José Luis Orihuela, "profesor universitario, conferenciante y bloguer" - tal y como él mismo se define-, habla sobre la interactividad como una potencia o una capacidad de los dispositivos (ordenadores y redes que actualiza o ejecuta el usuario en la medida en que inicia acciones que generan una respuesta por parte del sistema o de otros usuarios. Tras unas preguntas para adentrarnos en dicho concepto, Orihuela relaciona interactividad con diálogo y otros conceptos.
Moessbauer, TEM/SAED and XRD investigation on waste dumps of the Valea lui Stan gold mines
Energy Technology Data Exchange (ETDEWEB)
Constantinescu, Serban Grigore, E-mail: email@example.com [National Institute of Materials Physics, Bucharest-Magurele (Romania); Udubasa, Sorin S.; Udubasa, Gheorghe [University of Bucharest, Fac. of Geology and Geophysics (Romania); Kuncser, Victor; Popescu-Pogrion, Nicoleta; Mercioniu, Ionel; Feder, Marcel [National Institute of Materials Physics, Bucharest-Magurele (Romania)
The complementary investigation techniques, Moessbauer spectroscopy, transmission electron microscopy with selected area electron diffraction (TEM/SAED), X-ray diffraction (XRD) have been used to investigate the fate of the Valea lui Stan, Romania, gold-ore nanoscale-minerals during the long time of residence in the waste dumps. The preliminary investigations showed such waste dumps to contain significant amount of metals which cannot be identified by conventional methods. An intense research activity started up in order to evaluate the possibilities to recycle Valea lui Stan waste dumps and to recover metals by chemical or phytoextraction procedures. The waste dumps naturally show different mineral constituents with clay minerals as major phases, observed by XRD-technique. Although the waste dumps materials have whitish-yellowish colours, MOeSSBAUER technique evidences the presence of the finely dispersed iron bearing minerals. The authors are focusing to inspect and analyze Fe-compounds in the samples collected from Valea lui Stan's waste dumps in order to identify the magnetic phases by Moessbauer technique.
Concentrations of persistent organic pollutants (POPs) and heavy metals in soil from San Luis Potosí, México.
Perez-Vazquez, Francisco Javier; Flores-Ramirez, Rogelio; Ochoa-Martinez, Angeles Catalina; Orta-Garcia, Sandra Teresa; Hernandez-Castro, Berenice; Carrizalez-Yañez, Leticia; Pérez-Maldonado, Iván N
The aim of this study was to assess the levels of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (DDE), and four heavy metals (arsenic, cadmium, lead, and mercury) in soil from the city of San Luis Potosí in Mexico. In order to confirm the presence of the previously mentioned compounds, outdoor surface soil samples were collected and analyzed by gas chromatography/mass spectrometer for PBDEs, PCBs, DDT, and DDE. Meanwhile, heavy metals were quantified using the atomic absorption spectrophotometry technique. The total PBDEs levels ranged from 5.0 to 134 μg/kg dry weight (dw), with a total mean PBDEs level of 22.0 ± 32.5 μg/kg dw (geometric mean ± standard deviation). For PCBs, the total mean level in the studied soil was 21.6 ± 24.7 μg/kg dw (range, Luis Potosí, Mexico, and considering that soil is an important pathway of exposure for people, a biomonitoring program for the surveillance of the general population in the city of San Luis Potosi is necessary.
Rating the quality of the landscape of Sierra de las Quijadas National Park, Province of San Luis, Argentina
International Nuclear Information System (INIS)
Maero, I.; Rivarola, D.; Tognelli, G.
The National Park Sierra de las Quijadas is located to 120 km to the northwest of the Province of San Luis, Argentina. The study area is of 24,000 hectares, that correspond to 32 % of the total surface, this surface covers the totality with the Potrero de la Aguada and the next zones, the same one was selected because it conforms at the present time the zone of greater frequency of visitors within the Park. The objective of this work is centered in the obtaining of the Total Quality of the Landscape, having compared the demand of beauty to the rest of the other natural resources, to be able to make proposals to improve the Plan of Handling that takes ahead the Administration of National Parks. The used Methodology is the described one by Cendrero et. al. (1987), it is an indirect valuation that is carried out through the components of the landscape and allows to determine the Intrinsic Visual Quality and the Fragility of each one of the Environmental Units in which the park is divided. This analysis allowed to determine 2 Total Qualities of Landscape, that have been mapped using aerial photography equipment and materials and SIG, with field control. This investigation is developed within the Project of Investigation Geology of the Neogeno and Cuaternario of the Mountain range of San Luis, Faculty of Sciences Physical, Mathematics and Natural - National University of San Luis, Argentina. (author)
Modification of a Community Garden to Attract Native Bee Pollinators in Urban San Luis Obispo, California
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Robbin W. Thorp
Full Text Available Gardens have become increasingly important places for growing nutritional food, for conserving biodiversity, for biological and ecological research and education, and for community gathering. Gardens can also be designed with the goal of attracting specific wildlife, like birds and butterflies, but pollinators, like bees, can also be drawn to specially planned and modified gardens. A community garden in San Luis Obispo, California provided the setting for modification with the goal of attracting native bee pollinators by planting known bee-attractive plants. The local gardeners participated in a survey questionnaire and focused interviews to provide their input and interest in such a project. Presentations on our work with native bees in urban environments and gardening to attract bees were also given to interested gardeners. Work of this type also benefited from a lead gardener who managed donated bee plants and kept up momentum of the project. Modification of the garden and monitoring of native bees started in 2007 and continued through the growing season of 2009. Diversity of collected and observed native bees has increased each year since 2007. To date, 40 species in 17 genera of mostly native bees has been recorded from the garden, and this number is expected to increase through time.
Epidemiological profile of leprosy in municipality of Sao Luis - Ma from 2006 to 2010
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Líndia Kalliana da Costa Araújo Alves Carvalho
Full Text Available Objetivo: Analisar o perfil epidemiológico da Hanseníase em São Luís - MA no período de 2006 a 2010. Método: Trata-se de um estudo descritivo, exploratório, quantitativo de casos de hanseníase no município de São Luis- MA, em 2006 a 2010. Os dados foram coletados no Departamento de Informática do Sistema Único de Saúde (DATASUS. Foram coletadas as informações: taxa de incidência, classificação operacional, faixa etária e forma clínica. Resultados: O presente estudo demonstrou altas taxas de incidência sendo a mais alta em 2006. A forma multibacilar foi a mais diagnosticada com ápice em 2009, quanto a faixa etária predominou os maiores de 15 anos. As formas clínicas predominantes foram a dimorfa e a tuberculóide. Conclusão: Os profissionais de saúde devem conhecer medidas profiláticas, avaliação e tratamento para evitar que esses números continuem crescendo e evitar assim incapacidades físicas.
Una mirada a Donde ladrón no llega de Luis Hernáez
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Nini Johanna Sánchez Ávila
Full Text Available En 1996 aparece publicada la obra Donde ladrón no llega, del escritor paraguayo Luis Hernáez; este trabajo plantea una nueva lectura de la experiencia de las Reducciones Jesuitas en el Paraguay. Es, precisamente, esa forma de valoración en la recreación de la historia la que motiva este texto, ya que presenta una reconstrucción y una mirada crítica sobre un proyecto utópico adelantado en América. Tal propuesta es evaluada desde las voces de aquellos que –aún siendo protagonistas directos del evento social- no tuvieron una voz que se destacara en la delimitación de esta experiencia. Así, se abordará qué tipo de visión de la historia plantea el autor y cómo esta perspectiva se desarrolla en torno a una concepción específica de la propuesta de la utopía para América Latina.
Analysis of José Luis Rodríguez Zapatero's nonverbal communication
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Imelda Rodríguez-Escanciano, Ph.D.
Full Text Available Aware of television's high level of persuasion and impact, politicians have progressively adapted their messages to the guidelines of the audiovisual media in order to strongly persuade TV viewers, which are seen as potential voters. Currently, the communication, marketing and telegenicity teams of most political parties do not only train their politicians to effectively use verbal communication, but they also try to reinforce their non-verbal communications skills, because they understand that a really effective message is only created through the correct combination of both dimensions. This article presents an in-depth study of the nonverbal communication displayed by the Prime Minister of Spain, José Luis Rodríguez Zapatero, during the first quarter of 2010 when a political topic predominated in the agenda: the financial crisis. Through content analysis, and a self-developed methodology, the study aims to decipher the strategic meaning of this political leader's kinesic behaviour in the second edition of Telediario, the news programme broadcast by Spain's Public TV Network (Televisión Española, aka, TVE.
The pastoral implications of human freedom according to Juan Luis Segundo
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Vicente de Paula Ferreira
Full Text Available The paper aims to reflect the issue of human freedom based on the underlying principles of the Christian faith in a time of anthropological vulnerability, especially in Latin American. It holds that Christianity must insist on its proposal to promote universal goodwill, despite a human horizon marked by selfishness and lust for power and money. This approach presupposes a radical position of a listener of the divine mystery, revealed in Jesus Christ, as a way to fulfill the human condition. Theoretical framework: Liberation Theology, in the view of Juan Luis Segundo, and its well-established tradition of transforming realities of injustice through faith, comprises the core argument of this text. Findings: Christian salvation necessarily implies the kenosis (κένωσις of Jesus, i.e., Christ "emptied Himself" (Ph. 2:7, and through His humble dispossession, He broke with all closed systems of the world, and inaugurated a new venture of a liberated freedom: the agape of love. Conclusion: Christian praxis as daily care for the poorest and prophecy of forgiveness rescues the memory of the victims of all forms of human selfishness.
Corporalidad, espacio y nuevas formas de socialidad en la cinematografía de Luis Ortega
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Esteban Marcos Dipaola
Full Text Available El artículo analiza la dimensión visual de la corporalidad tal como aparece en las estéticas, las narrativas y las imágenes de los films de Luis Ortega, Caja negra y Monobloc. Partiendo de esa exposición de la corporalidad y también de los gestos y los afectos, se busca analizar la conformación de un espacio social íntimo y cotidiano que en la cinematografía de Ortega se hace presente con la figura de los micromundos, para comprender las nuevas formas de socialidad y la nueva expresión de la experiencia social, ahora dada en la materialidad de los cuerpos como formas de vinculación. Así, las relaciones entre cuerpo y vida o entre cuerpo y dolor se conjugan en el artículo como formas de pensar las condiciones de una nueva experiencia social y cultural. Fecha de recepción: 19 de febrero de 2010. Fecha de aceptación: 14 de julio de 2010.
Syntactically Silent Subjects: Luis Muñoz and the Poetry of Ellipsis
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Judith Nantell
Full Text Available Luis Muñoz (1966 is one of contemporary Spain's most salient poets. His work has been described as demonstrating a discourse of ellipsis; yet no study has examined in detail his masterful use of syntactic and figurative omission. In fact, even though Muñoz's published collections to date span two centuries, no single study has been devoted to his decidedly innovative expressivity. His work has been commented on in various panoramic essays considering contemporary poetry published in Spain at this temporal intersection and a number of his poems have been gathered into noteworthy anthologies of this same era. His poetry has been nominated for prestigious awards in Spain and in 2001 Correspondencias 'Correspondences' received the fourth Premio Internacional de Poesía del 27 as well as the Premio de Ojo Crítico de Poesía . The present study examines Muñoz's most recent Querido silencio (2006 'Dear Silence' where ellipsis figures prominently as the poet maximizes and exploits conceptual and linguistic efficiency. In one exemplary poem, "Dejar la poesía" 'Leave Poetry,' two syntactically silent subjects engage in an innovative conversation concerning the nature of poetry. At the same time this intriguing dialogue also offers a unique response to the essential question framing this poem and the collection as a whole: Why is poetry an addiction?
Luis G. Urbina, la definición de un género literario
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Ernesto Emiliano Romero
Full Text Available El artículo es una aproximación crítica a las crónicas del autor mexicano Luis G. Urbina; investigación que encontró su origen en la importancia de la crónica modernista como espacio creativo y reflexivo cuyas características y alcances aún hoy generan un sinnúmero de trabajos críticos. Tanto José Martí como Manuel Gutiérrez Nájera y otros de los autores emblemáticos del modernismo, han sido escrutados y valorados a lo largo de estos años. Sin embargo, Urbina ha permanecido relegado a las historias de la literatura y a las bibliotecas, lo cual sugiere un casi nulo conocimiento de su obra. En este ensayo se analizan algunos de los textos incluidos en su libro Cuentos vividos y crónicas soñadas, publicado en 1915, para contribuir a la revalorización y difusión de su obra a 150 años de su nacimiento.
The eolic fluvial succession and paleoclimatic evolution of Rio Conlara, San Luis, Argentina
International Nuclear Information System (INIS)
Chiesa, J.
The outcroping deposits in the ravines of the Conlara River are dominated by silt with subordinated and variable percentages of sand and clays. In the section that is described, at the south of the town of Santa Rosa del Conlara, these materials have been deposited responding generally climatic changing conditions. The base of the profile, assigned to the late Pleistocene, contains extint fauna of the Lujanense and a datation of 8950 B.P., and it is represented by fluvial sandy gravels. The overlaying succession, assigned to the Holocene, shows an intercalation of horizons generated by eolic-loessic deposits and deposits with development of pedogenetic processes. The whole succession shows characteristic of corresponding to a vegetated plain, next to the river flood plain. The discriminated horizons are the result of a detailed sampling and the representation of range parameters of the same ones, in function of the depth, this last one oscillates between 6 and 8 meters. The quaternary deposits of the region, support indistinctly as on the crystalline basement of San Luis range, as on the calcretes assigned to the Neogene [es
Espacios Rurales ¿Crisis sistémica o brotes verdes? Entrevista con Luis Camarero.
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Luis Camarero Rioja
Full Text Available Entrevista a Luis Camarero Rioja es Catedrático de Sociología de la UNED. Experto en sociología rural desde que iniciara en los años 90 su trayectoria como investigador en el Seminario de Estudios Rurales impulsado por Josechu Vicente-Mazariegos (UCM. Recibió el Premio Nacional de Investigaciones Agrarias (1993, MAPA y el Premio de Tesis Doctorales (1993, Colegio de Sociólogos. Ha dirigido distintos proyectos de investigación dedicados especialmente a la visibilización del trabajo femenino en áreas rurales y a la sostenibilidad social en el mundo rural. Autor de numerosas publicaciones de referencia como Del éxodo rural y del éxodo urbano (1993. Madrid: Ministerio de Agricultura, La población rural de España. De los desequilibrios a la sostenibilidad social (2009. Barcelona: La Caixa o "Foreigners, Neighbours, Immigrants: Translocal mobilities in rural areas in Spain" en Translocal Ruralism, obra editada por Hedberg y Carmo (2012. London: Springer.
Application of environmental Cs-137 techniques to problems of sediment redistribution Sungai Lui Representative Basin, Selangor, Malaysia
International Nuclear Information System (INIS)
Daud bin Mohamad; Moo Siew Pheng.
Secondary standard dosimetry laboratory (UPDK), Nuclear Energy Unit, is well equipped with all necessary irradiation facilities and radiation measuring devices. The establishment of the Laboratory is partly aimed at giving calibration services for all kinds of dosemeters, personnel radiation monitoring by using film badges and TLD etc. In running the above services, safe and correct handling procedures of the mentioned facilities and devices are necessary. Furthermore, the accuracy of measurements is of great importance. This report outlined the procedures of handling the equipment, of performing experimental works as well as of getting the mentioned services from UPDK. This report is referred as a guide containing all the standard procedures aiming at a safety operation of radiation and electrical devices and finally to achieve a high degree of dosimetric accuracies. (author)
El manejo de los residuos sólidos municipales: un enfoque antropológico. El caso de San Luis Potosí, México
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Mauricio Guzmán Chávez
Full Text Available El artículo presenta una revisión crítica de la literatura especializada en la gestión de residuos sólidos municipales y una reflexión sobre los aspectos políticos vinculados a dicha gestión. Ello, a partir de un estudio de caso: el tiradero Peñasco situado en la periferia de la zona metropolitana de San Luis Potosí. La reflexión se enfoca, particularmente, en las estrategias empleadas por los pepenadores (separadores de basura para defender su fuente de trabajo, esto es, en sus luchas y negociaciones para incidir en la política municipal y en las decisiones gerenciales de la empresa habilitada para administrar dicho sitio. Nuestro análisis ofrece evidencia sobre las dificultades y la insuficiencia de los enfoques propuestos desde la ingeniería ambiental para generar cambios en la gestión de residuos sólidos y muestra el papel decisivo que juegan los intereses y percepciones de los distintos actores en la definición del control territorial y la solución de la disposición final de residuos en tanto problemática social.
International Nuclear Information System (INIS)
Goldhaber, G.
In my talk I will cover the period 1973 to 1976 which saw the discoveries of the J/psi and psi' resonances and most of the Psion spectroscopy, the tau lepton and the D 0 ,D + charmed meson doublet. Occasionally I will refer briefly to more recent results. Since this conference is on the history of the weak-interactions I will deal primarily with the properties of naked charm and in particular the weakly decaying doublet of charmed mesons. Most of the discoveries I will mention were made with the SLAC-LBL Magnetic Detector or MARK I which we operated at SPEAR from 1973 to 1976. 27 references
Science of the science, drug discovery and artificial neural networks.
Patel, Jigneshkumar
Drug discovery process many times encounters complex problems, which may be difficult to solve by human intelligence. Artificial Neural Networks (ANNs) are one of the Artificial Intelligence (AI) technologies used for solving such complex problems. ANNs are widely used for primary virtual screening of compounds, quantitative structure activity relationship studies, receptor modeling, formulation development, pharmacokinetics and in all other processes involving complex mathematical modeling. Despite having such advanced technologies and enough understanding of biological systems, drug discovery is still a lengthy, expensive, difficult and inefficient process with low rate of new successful therapeutic discovery. In this paper, author has discussed the drug discovery science and ANN from very basic angle, which may be helpful to understand the application of ANN for drug discovery to improve efficiency.
Rule Induction-Based Knowledge Discovery for Energy Efficiency
Chen, Qipeng; Fan, Zhong; Kaleshi, Dritan; Armour, Simon M D
Rule induction is a practical approach to knowledge discovery. Provided that a problem is developed, rule induction is able to return the knowledge that addresses the goal of this problem as if-then rules. The primary goals of knowledge discovery are for prediction and description. The rule format knowledge representation is easily understandable so as to enable users to make decisions. This paper presents the potential of rule induction for energy efficiency. In particular, three rule induct...
de Mestre, Neville
Earlier "Discovery" articles (de Mestre, 1999, 2003, 2006, 2010, 2011) considered patterns from many mathematical situations. This article presents a group of patterns used in 19th century mathematical textbooks. In the days of earlier warfare, cannon balls were stacked in various arrangements depending on the shape of the pile base…
African Journals Online (AJOL)
Discovery and Innovation is a journal of the African Academy of Sciences (AAS) ... World (TWAS) meant to focus attention on science and technology in Africa and the ... of Non-wood Forest Products: Potential Impacts and Challenges in Africa ...
DEFF Research Database (Denmark)
Christiansen, Elisabeth; Hansen, Steffen V F; Urban, Christian
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical...
International Nuclear Information System (INIS)
McKay, H.A.C.
In this article by the retired head of the Separation Processes Group of the Chemistry Division, Atomic Energy Research Establishment, Harwell, U.K., the author recalls what he terms 'an exciting drama, the unravelling of the nature of the atomic nucleus' in the years before the Second World War, including the discovery of fission. 12 references. (author)
Martin, Paul S.
Discusses a model for explaining the spread of human population explosion on North American continent since its discovery 12,000 years ago. The model may help to map the spread of Homo sapiens throughout the New World by using the extinction chronology of the Pleistocene megafauna. (Author/PS)
On reliable discovery of molecular signatures
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Björkegren Johan
Full Text Available Abstract Background Molecular signatures are sets of genes, proteins, genetic variants or other variables that can be used as markers for a particular phenotype. Reliable signature discovery methods could yield valuable insight into cell biology and mechanisms of human disease. However, it is currently not clear how to control error rates such as the false discovery rate (FDR in signature discovery. Moreover, signatures for cancer gene expression have been shown to be unstable, that is, difficult to replicate in independent studies, casting doubts on their reliability. Results We demonstrate that with modern prediction methods, signatures that yield accurate predictions may still have a high FDR. Further, we show that even signatures with low FDR may fail to replicate in independent studies due to limited statistical power. Thus, neither stability nor predictive accuracy are relevant when FDR control is the primary goal. We therefore develop a general statistical hypothesis testing framework that for the first time provides FDR control for signature discovery. Our method is demonstrated to be correct in simulation studies. When applied to five cancer data sets, the method was able to discover molecular signatures with 5% FDR in three cases, while two data sets yielded no significant findings. Conclusion Our approach enables reliable discovery of molecular signatures from genome-wide data with current sample sizes. The statistical framework developed herein is potentially applicable to a wide range of prediction problems in bioinformatics.
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María Cecilia Arango
Full Text Available Las quebradas La Cristalina y La Risaralda son las fuentes que abastecen el acueducto del área urbana del municipio de San Luis, Antioquia. El propósito de este estudio fue elaborar un mapa de calidad de agua que sirva como base de comparación de la evolución de las quebradas y justifique la inversión de los recursos del Municipio en el mejoramiento prioritario de los tramos más críticos. Para establecer la calidad del agua se determinaron indicadores físicos, químicos y biológicos, entre ellos algunas características físicas de las quebradas como tipo de sustrato, cobertura de riberas y hábitats acuáticos, temperatura, conductividad, oxígeno, pH, coliformes y macroinvertebrados acuáticos. A partir de los datos colectados se calcularon los índices BMWP/Col1, ASPT, ETP, índice de dípteros y de equidad. Con los resultados obtenidos del ASPT se construyó el mapa de calidad de agua para ambas quebradas. Las quebradas están bien oxigenadas debido a la turbulencia provocada por la conformación rocosa de su lecho, que a su vez permite la diversidad de macroinvertebrados acuáticos. Sin embargo, algunos tramos de estas corrientes están sometidos a contaminación de origen doméstico y agropecuario, lo cual limita sus condiciones de uso.The streams La Cristalina and La Risaralda are the water sources for the urban area of the Municipality of San Luis, Antioquia. The intention of this study was to develop a map of water quality that serves as base as comparison of the evolution of the streams and allows the high-priority destination of the resources of the Municipality in the improvement of those more critical sections. In order to determine the quality of the water, parameters and some characteristics of the stream that can alter the quality of the water were measured, like substrate of the bed, cover of banks, aquatic habitats, temperature, conductivity, oxygen, pH, coliforms, and aquatic macroinvertebrates. The indices calculated
Un bosquejo de la filosofía de Luis Felipe Alarco Larrabure (1913-2005
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Víctor S. Céspedes Agüero
Full Text Available Nació en Lima, en 1913. Sus padres fueron Gerardo Alarco Calderón y Rosa Mercedes Larraburre y Correa. Durante cinco años, cursó Filosofíaen Alemania con Nicolai Hartmann y Martin Heidegger. De estos estudios de filosofía en universidades alemanas Luis Felipe Alarco evocará:"Mi experiencia del nazismo [...] me hizo comprender que toda forma de dictadura, cualesquiera que sean sus justificaciones –la sinrazónconvertida en furor–, constituye un retroceso en la historia y un menos en la condición humana"1. Al regresar optó el Grado de Bachiller en Humanidades con una tesis sobre El Diálogo Agonal en el Problema de la Inmortalidad (1941 y el Grado de Doctorado en Humanidades con la tesis Lo metafísico en la Filosofía de Nicolai Hartmann (1941. Fue docente en las Facultades de Letras y de Educación. Ejerció la Jefatura del Departamentode Investigaciones Pedagógicas del Instituto Psico-Pedagógico Nacional. Estuvo entre los que fundaron la Sociedad Peruana de Filosofía. Participó en el Congreso Internacional de Filosofía en Lima, que se realizó del 16 al 26 de Julio de 1951. Participó el 2 de agosto de 1994 en el Seminario El marxismo de José Carlos Mariátegui efectuado en el marco del Vº Congreso Nacional de Filosofía realizado en la Universidad de Lima y en el homenaje por el 80 aniversario de Francisco Miró Quesada Cantuarias realizado por la Facultad de Matemática en 1998. Falleció el quince de octubre de 2005.
Brote de encefalitis de San Luis en el Área Metropolitana Buenos Aires
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Alfredo Seijo
Full Text Available Se describen los hallazgos epidemiológicos y clínicos de 13 enfermos con diagnóstico de infección por virus de la encefalitis de San Luis, con transmisión entre enero y marzo de 2010, en el Area Metropolitana Buenos Aires (AMBA. Los 13 enfermos, promedio de edad 38 años, tuvieron un comienzo agudo caracterizado por hipertermia y cefalea. Entre los días dos y diez de iniciados los síntomas, 7/13 enfermos tuvieron signos y síntomas de compromiso neurológico caracterizado por meningitis sin signos encefálicos en 1/7. En 6/7 los hallazgos más frecuentes fueron: rigidez de nuca, desorientación temporoespacial, fotofobia, confusión y alteración del lenguaje. Dos resonancias magnéticas y un electroencefalograma presentaron signos de afectación de lóbulos temporales. El líquido cefalorraquídeo se caracterizó por pleocitosis con predominio de células mononucleadas, glucorraquia normal y discreto aumento de proteínas. No hubo casos fatales. En 6/13 pacientes la sospecha clínica inicial fue dengue. Por la agrupación espacial y temporal de los casos puede considerarse un brote epidémico, el primero conocido en el AMBA, ya que no se había notificado previamente la circulación epidémica del virus.
La ética y el problema de Dios en Juan Luis Vives (1492-1540
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Alfonso Maestre Sánchez
Full Text Available In the historical, turbulent and exciting times of the Renaissance Humanism, characterized by a return to classic Antiquity, and the renovation of all cultural manifestations, both philosophy and religion are affected from their very foundations. This scholastic crisis affects in such a way the conscience, of the individuals and the people that it demands a solution immediate although provisional solution, so that we continuing even the business of living. No wonder that among the ruins of tomist morality, some moralists arise, as that of Justus Lipsius (1547-1606, engased in renovating the stoic doctrines of Epicteto (ca. 50 to. of C. -125/138 and Séneca (ca. 4-65, and that of Pierre Gassendi (1592-1655, determined to Christianize Epicuro. For some could be a summarise of the Ethics of the Renaissance others believe that the first Ethics of modern philosophy should be considered to be a product of the Renaissance, even if it does not belong chronologically to it they meam Descartes (1596-1650, Spinoza (1632-1677 and Kant (1724-1804. However according to the opinion of some significant authors, we dont need to go back to Kant to find the authentic Ethics of the Renaissance. Juan Luis Vives published in 1524 a small booklet titled Introductio ad Sapientiam that for its internal ideological structure and its origin senequista and christan leaning occupies a privileged place within modern Ethic, and if we take accourt his content and chronology it can be considered as the Ethics of the Renaissance, at least of the Spanish Renaissance.
Arsenic and cadmium exposure in children living near a smelter complex in San Luis Potosi, Mexico
Energy Technology Data Exchange (ETDEWEB)
Diaz-Barriga, F.; Santos, M.A.; Mejia, J.J.; Batres, L.; Yanez, L.; Carrizales, L.; Vera, E.; del Razo, L.M.; Cebrian, M.E. (Universidad Autonoma de San Luis Potosi (Mexico))
The main purpose of this study was to assess environmental contamination by arsenic and cadmium in a smelter community (San Luis Potosi City, Mexico) and its possible contribution to an increased body burden of these elements in children. Arsenic and cadmium were found in the environment (air, soil, and household dust, and tap water) as well as in the urine and hair from children. The study was undertaken in three zones: Morales, an urban area close to the smelter complex; Graciano, an urban area 7 km away from the complex; and Mexquitic, a small rural town 25 km away. The environmental study showed that Morales is the most contaminated of the zones studied. The range of arsenic levels in soil (117-1396 ppm), dust (515-2625 ppm), and air (0.13-1.45 micrograms/m3) in the exposed area (Morales) was higher than those in the control areas. Cadmium concentrations were also higher in Morales. Estimates of the arsenic ingestion rate in Morales (1.0-19.8 micrograms/kg/day) were equal to or higher than the reference dose of 1 microgram/kg/day calculated by the Environmental Protection Agency. The range of arsenic levels in urine (69-594 micrograms/g creatinine) and hair (1.4-57.3 micrograms/g) and that of cadmium in hair (0.25-3.5 micrograms/g) indicated that environmental exposure has resulted in an increased body burden of these elements in children, suggesting that children living in Morales are at high risk of suffering adverse health effects if exposure continues.
Brown, Nathan; Cambruzzi, Jean; Cox, Peter J; Davies, Mark; Dunbar, James; Plumbley, Dean; Sellwood, Matthew A; Sim, Aaron; Williams-Jones, Bryn I; Zwierzyna, Magdalena; Sheppard, David W
Interpretation of Big Data in the drug discovery community should enhance project timelines and reduce clinical attrition through improved early decision making. The issues we encounter start with the sheer volume of data and how we first ingest it before building an infrastructure to house it to make use of the data in an efficient and productive way. There are many problems associated with the data itself including general reproducibility, but often, it is the context surrounding an experiment that is critical to success. Help, in the form of artificial intelligence (AI), is required to understand and translate the context. On the back of natural language processing pipelines, AI is also used to prospectively generate new hypotheses by linking data together. We explain Big Data from the context of biology, chemistry and clinical trials, showcasing some of the impressive public domain sources and initiatives now available for interrogation. © 2018 Elsevier B.V. All rights reserved.
Discovery and preclinical development of new antibiotics.
Hughes, Diarmaid; Karlén, Anders
Antibiotics are the medical wonder of our age, but an increasing frequency of resistance among key pathogens is rendering them less effective. If this trend continues the consequences for cancer patients, organ transplant patients, and indeed the general community could be disastrous. The problem is complex, involving abuse and overuse of antibiotics (selecting for an increasing frequency of resistant bacteria), together with a lack of investment in discovery and development (resulting in an almost dry drug development pipeline). Remedial approaches to the problem should include taking measures to reduce the selective pressures for resistance development, and taking measures to incentivize renewed investment in antibiotic discovery and development. Bringing new antibiotics to the clinic is critical because this is currently the only realistic therapy that can ensure the level of infection control required for many medical procedures. Here we outline the complex process involved in taking a potential novel antibiotic from the initial discovery of a hit molecule, through lead and candidate drug development, up to its entry into phase I clinical trials. The stringent criteria that a successful drug must meet, balancing high efficacy in vivo against a broad spectrum of pathogens, with minimal liabilities against human targets, explain why even with sufficient investment this process is prone to a high failure rate. This emphasizes the need to create a well-funded antibiotic discovery and development pipeline that can sustain the continuous delivery of novel candidate drugs into clinical trials, to ensure the maintenance of the advanced medical procedures we currently take for granted.
El basamento de la sierra de San Luis: Nuevas evidencias magnéticas y sus implicancias tectónicas The basement of Sierra de San Luis: New magnetic evidence and tectonic implication
CJ Chernicoff; VA Ramos
Los mapas aeromagnéticos disponibles de las sierras de San Luis y Comechingones en el sector sudoriental de las Sierras Pampeanas de Argentina, permiten examinar las características geológicas y estructurales de las unidades metamórficas e intrusivas del basamento de la región. A través de la aplicación del filtro de continuación ascendente a los datos del campo magnético total reducido al polo, se ha podido observar la configuración profunda de las distintas unidades. Entre ellas se destaca ...
Distribución del ocelote (Leopardus pardalis en San Luis Potosí, México Distribution of the ocelot (Leopardus pardalis in San Luis Potosí, Mexico
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Jesús Manuel Martínez-Calderas
Full Text Available Para definir la distribución geográfica del ocelote en el estado de San Luis Potosí, México, se obtuvieron nuevos registros de la especie. El estudio se realizó de enero de 2007 a abril de 2009. Se obtuvieron 41 registros de ocelotes por medio de entrevistas y trampeo-fotográfico. Los registros se localizaron en comunidades vegetales de selva baja caducifolia (37%, matorral submontano (22%, bosque de encino (15%, selva mediana (10%, selva alta perennifolia, bosque mesófilo de montaña, bosque de pino-encino y matorral desértico micrófilo (10%. La presencia de ocelotes se ubicó en los municipios de Ciudad del Maíz, El Naranjo, Cerritos, Guadalcázar, San Nicolás Tolentino y Ciudad Valles en de elevaciones de 38 a 2 400 m snm. Los resultados de esta investigación sugieren una distribución del ocelote más hacia el oeste del estado respecto a su distribución original. El presente estudio definió nuevas regiones con presencia de ocelotes que pueden ser consideradas en el desarrollo de estrategias de conservación de la especie en el estado de San Luis Potosí.To determine the geographic distribution of ocelot in the state of San Luis Potosí, Mexico, we obtained new records. The study was conducted from January 2007 to April 2009. We recorded 41 ocelot records by interviews and camera-trapping. Ocelots records were located in tropical deciduous forest (37%, semitropical thornscrub (22%, oak forest (15%, tropical forest (10%, tall tropical deciduous forest, desert scrub, pine-oak forest and clouded forest (10%. Ocelot records were located in the municipalities of Ciudad del Maíz, El Naranjo, Cerritos, Guadalcazar, San Nicolás Tolentino and Ciudad Valles where the elevation ranged from 38 to 2 400 m. The evidence of this research suggests that ocelot range is more extended to the west than its original geographical range. This study defined new regions with presence of ocelots that may be considered to develop conservation strategies
Fossil content and structural relationships of the San Luis zone and the Caborca zone of NW Sonora, Mexico, suppression of the precambrian Z of Caborca
International Nuclear Information System (INIS)
Radelli, Luigi; Solis Weiss, Vivianne; Dorame Navarro, Miguel; De La Cruz Ortega, Lissette del Carmen; Urrutia, Jose
In the Caborca region of western Sonora a Precambrian Z does not cover a unique Precambrian socle as previously believed. Two tectonic zones occur there instead: the San Luis Zone and the Caborca Zone. The first is comprised of the Precambrian San Luis socle of gneiss and granite, crossed by 1.1 Ga old anorthosites, the San Luis sedimentary cover, and, above it, a Lower Jurassic volcano-sedimentary sequence. The Caborca Zone consists of the Precambrian Bamori socle of parametamorphic rocks crossed by 1.1 Ga old Aibo granite, and of the Gamuza sedimentary cover. 1.1 Ga ago the two zones were far away from each other. They have been brought together by the Nevadian orogeny. Both zones are allochthonous, and the Caborca Zone is a nappe upon the San Luis Zone. The lowermost units of the Gamuza cover furnished psammocorals and a possible Pterophyllum jageri (?). Accordingly, its geological age is either Palaeozoic or Triassic.The San Luis cover furnished Nematophites [Prototaxites (?) and Nematothallus] from its lower part; Calcispongiae, Cardaicarpus' seeds, and Artisia from its upper part Thus, it is a Devono-Carboniferous unit. The study area belongs in the Baja-Borderland block, which underwent, an Eocene northwards drifting of about 900 - 1000 km, and a 30 celsius degrade to 40 celsius degrade clockwise rotation relative to the main part of Sonora.
Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosí City, Mexico
López-Revilla, Rubén; Pineda, Marco A; Ortiz-Valdez, Julio; Sánchez-Garza, Mireya; Riego, Lina
Background In San Luis Potosí City cervical infection by human papillomavirus type 16 (HPV16) associated to dysplastic lesions is more prevalent in younger women. In this work HPV16 subtypes and variants associated to low-grade intraepithelial lesions (LSIL), high-grade intraepithelial lesions (HSIL) and invasive cervical cancer (ICC) of 38 women residing in San Luis Potosí City were identified by comparing their E6 open reading frame sequences. Results Three European (E) variants (E-P, n = 27; E-T350G, n = 7; E-C188G, n = 2) and one AA-a variant (n = 2) were identified among the 38 HPV16 sequences analyzed. E-P variant sequences contained 23 single nucleotide changes, two of which (A334G, A404T) had not been described before and allowed the phylogenetic separation from the other variants. E-P A334G sequences were the most prevalent (22 cases, 57.9%), followed by the E-P Ref prototype (8 cases, 21.1%) and E-P A404T (1 case, 2.6%) sequences. The HSIL + ICC fraction was 0.21 for the E-P A334G variants and 0.00 for the E-P Ref variants. Conclusion We conclude that in the women included in this study the HPV16 E subtype is 19 times more frequent than the AA subtype; that the circulating E variants are E-P (71.1%) > E-T350G (18.4%) > E-C188G (5.3%); that 71.0% of the E-P sequences carry the A334G single nucleotide change and appear to correspond to a HPV16 variant characteristic of San Luis Potosi City more oncogenic than the E-P Ref prototype. PMID:19216802
International Nuclear Information System (INIS)
Six, J.
The neutron: who had first the idea, who discovered it, who established its main properties. To these apparently simple questions, multiple answers exist. The progressive discovery of the neutron is a marvellous illustration of some characteristics of the scientific research, where the unforeseen may be combined with the expected. This discovery is replaced in the context of the 1930's scientific effervescence that succeeded the revolutionary introduction of quantum mechanics. This book describes the works of Bothe, the Joliot-Curie and Chadwick which led to the neutron in an unexpected way. A historical analysis allows to give a new interpretation on the hypothesis suggested by the Joliot-Curie. Some texts of these days will help the reader to revive this fascinating story [fr
Atlas of Astronomical Discoveries
Schilling, Govert
Four hundred years ago in Middelburg, in the Netherlands, the telescope was invented. The invention unleashed a revolution in the exploration of the universe. Galileo Galilei discovered mountains on the Moon, spots on the Sun, and moons around Jupiter. Christiaan Huygens saw details on Mars and rings around Saturn. William Herschel discovered a new planet and mapped binary stars and nebulae. Other astronomers determined the distances to stars, unraveled the structure of the Milky Way, and discovered the expansion of the universe. And, as telescopes became bigger and more powerful, astronomers delved deeper into the mysteries of the cosmos. In his Atlas of Astronomical Discoveries, astronomy journalist Govert Schilling tells the story of 400 years of telescopic astronomy. He looks at the 100 most important discoveries since the invention of the telescope. In his direct and accessible style, the author takes his readers on an exciting journey encompassing the highlights of four centuries of astronomy. Spectacul...
Chiu, Charles Y
Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remain to be addressed, including the bioinformatics analysis and interpretation of large datasets, these technologies have been successful in rapidly identifying emerging outbreak threats, screening vaccines and other biological products for microbial contamination, and discovering novel viruses associated with both acute and chronic illnesses. Downstream studies such as genome assembly, epidemiologic screening, and a culture system or animal model of infection are necessary to establish an association of a candidate pathogen with disease. PMID:23725672
New K-Ar ages of volcanic rocks and associated mineralization in Canada Honda district, San Luis, Argentina
International Nuclear Information System (INIS)
Urbina, N.E.; Oggier, F.P
New K-Ar ages in the Late Tertiary gold-bearing volcanic belt of the Sierras Pampeanas of San Luis, Argentina are presented. At Canada Honda district, an age of 8.49±0.2 Ma yielded by Cerro del Valle andesite indicates that the dome emplacement postdates the Diente Verde eruptive event. An even younger age of 7.3±0.2 Ma was obtained for illite from hydrothermal alteration at La Reynela mineralization which is hosted by Cerro del Valle andesite (au)
José Teruel, Los años norteamericanos de Luis Cernuda: una singular propuesta de lectura
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Dana Guisasola
Full Text Available La presente reseña se aboca al reciente libro de José Teruel, Los años norteamericanos de Luis Cernuda. El crítico revisa un abundante material bibliográfico y da cuenta de los pormenores de la vida y obra del poeta español entre 1947 -año en el que el poeta llega a Nueva Inglaterra- y 1963, año de su muerte. El libro ha sido galardonado con el Premio de Investigación Literaria Gerardo Diego en 2013.
Ciudades invisibles. Tijuana en la obra de Federico Campbell, Luis Humberto Crosthwaite, Francisco Morales y Heriberto Yépez
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Diana Palaversich
This essay employs the concepts of "the haunted place" (Michel de Certeau and "the sense of place" (Kent Ryden to examine the representation of the US-Mexico border in the works of Federico Campbell, Luis Humberto Crosthwaite, Francisco Morales and Heriberto Yépez. While Campbell, Crosthwaite, and Morales represent Tijuana as a place imbued with personal and collective history, Yépez, in his most recent novel, Al otro lado, offers an apocalyptic vision of this border city, defined by narcoviolence, illegal immigration, and militarization.
A forgotten chapter of Mexican technology and science: Luis Gutiérrez Villegas and poliomyelitis in Mexico.
Velázquez-Arellano, Antonio
Two different types of vaccines were developed against poliomyelitis: The Salk vaccine using inactivated virus and the Sabin one, that was used later, after investigations assured its safety. The first one was made in Mexico with its own resources since 1957 thanks to the efforts of young researchers and technicians coordinated by Luis Gutiérrez-Villegas, M.D., who was a Clinical Pathologist, University Professor and President of the Mexican National Academy of Mexico. Copyright: © 2017 SecretarÍa de Salud.
Superinfection between Influenza and RSV Alternating Patterns in San Luis Potosí State, México
Velasco-Hernández, Jorge Xicoténcatl; Núñez-López, Mayra; Comas-García, Andreu; Cherpitel, Daniel Ernesto Noyola; Ocampo, Marcos Capistrán
The objective of this paper is to explain through the ecological hypothesis superinfection and competitive interaction between two viral populations and niche (host) availability, the alternating patterns of Respiratory Syncytial Virus (RSV) and influenza observed in a regional hospital in San Luis Potosí State, México using a mathematical model as a methodological tool. The data analyzed consists of community-based and hospital-based Acute Respiratory Infections (ARI) consultations provided by health-care institutions reported to the State Health Service Epidemiology Department from 2003 through 2009. PMID:25803450
Tecnología lítica y uso diferencial del espacio en Estancia La Suiza, San Luis, Argentina
Sario, Gisela Mariela
El trabajo pretende contribuir, desde la perspectiva de la organización de la tecnología, al conocimiento de las ocupaciones cazadoras-recolectoras que habitaron las inmediaciones de la Sierra de la Estanzuela, en la provincia de San Luis, Argentina. Se explican cómo fueron las secuencias de producción de herramientas en los sitios de la localidad arqueológica Estancia La Suiza, a partir del análisis de los materiales líticos recuperados en excavación y prospecciones sistemáticas. Las metod...
Clima y compromiso organizacional en una mediana empresa manufacturera de San Luis Potosí, S.L.P.
Crespo Bravo, Carolina
Este trabajo tiene como objetivo principal analizar la relación que existe entre clima y compromiso organizacional y de estos con las características personales. La muestra se integró con 80 trabajadores de una mediana empresa manufacturera ubicada en la ciudad de San Luis Potosí. Se realizó un estudio empírico transversal aplicando cuestionarios para clima organizacional de Araujo et al. (2011), el cual se construyó con características inherentes a las dimensiones: a) estilo de geren...
Fateful discovery almost forgotten
International Nuclear Information System (INIS)
The paper reviews the discovery of the fission of uranium, which took place fifty years ago. A description is given of the work of Meitner and Frisch in interpreting the Fermi data on the bombardment of uranium nuclei with neutrons, i.e. proposing fission. The historical events associated with the development and exploitation of uranium fission are described, including the Manhattan Project, Hiroshima and Nagasaki, Shippingport, and Chernobyl. (U.K.)
Luis Felipe Fajardo (1927-2013. Su vida y su obra
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Hernando Sarasti Obregón
Full Text Available FragmentoTeniendo en cuenta los grandes logros de este médico colombiano, en la Academia Nacional de Medicina se le rindió un homenaje a su memoria. Los ponentes de la sesión fueron los académicos Sarasti y Patiño. Por lo importante del tema, hemos querido incluir sus presentaciones en este artículo de la revista MEDICINA. El tema tocado por el doctor Sarasti fue el siguiente:El 5 de julio de 2013 falleció en los Estados Unidos en la ciudad de Palo Alto, California, el patólogo colombiano Dr. Luis Felipe Fajardo Lobo- Guerrero. Había nacido en Bogotá el 23 de enero de 1927 en el hogar de Don Luís Antonio Fajardo Suárez y Doña María Teresa Lobo-Guerrero.Se graduó como Bachiller en el Colegio de La Salle en 1944, hizo su medicatura rural en Restrepo (Meta y recibió el título de Médico en la Facultad de Medicina de la Universidad Nacional de Colombia en 1952. Inició su entrenamiento en Patología en el Hospital San Juan de Dios de Bogotá y lo continuó en los Estados Unidos en la Universidad de Yale entre 1954 y 1958. Ese mismo año fue certificado por el American Board of Pathology, contrajo matrimonio con Lorela Enterline y regresó a Colombia a ejercer su especialidad en el Hospital de la Samaritana.En noviembre de 1959 volvió a los Estados Unidos para ocupar un "locum tenens" en Connecticut en el New Britain General Hospital y regresó nuevamente a Colombia en octubre de 1960 como Profesor Asistente de Patología de la Universidad Nacional al mismo tiempo que fue Jefe del Laboratorio Clínico del Hospital San Juan de Dios.El Dr. Fajardo y el suscrito formábamos parte de la generación de médicos colombianos que hacia mediados del siglo XX viajamos a los Estados Unidos para especializarnos en diversas ramas de la Medicina.
Measurement of radon concentration in old metalliferous mines in San Luis, Argentina
Energy Technology Data Exchange (ETDEWEB)
Anjos, Roberto M.; Lacerda, Tiago; Rosas, Juan P. de [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/no, Gragoata, 24210-346, Niteroi, RJ (Brazil); Da Silva, Almy A.R. [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal Milton Tavares de Souza, s/no, Gragoata, 24210-346, Niteroi, RJ (Brazil); Instituto de Fisica, Universidade de Sao Paulo, P. O. Box 66318, 05314-970, Sao Paulo, SP (Brazil); Rizzotto, Marcos; Valladares, Diego L.; Velasco, Hugo [GEA, Instituto de Matematica Aplicada San Luis (IMASL), Universidad Nacional de San Luis, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ej. de los Andes 950, D5700HHW San Luis (Argentina); Yoshimura, Elisabeth M. [Instituto de Fisica, Universidade de Sao Paulo, P. O. Box 66318, 05314-970, Sao Paulo, SP (Brazil)
Radon levels in two old mines in San Luis, Argentina, were measured and analyzed. La Carolina gold mine and Los Condores tungsten mine are today used as tourism mines. CR-39 nuclear track detectors were used for this purpose. Measurements were performed during both winter and summer seasons. The findings show that in these environments, significant radon concentrations are subject to large seasonal fluctuations, due to the strong dependence on natural ventilation with the outside temperature variations. For both mines, high concentration values of {sup 222}Rn were observed in summer and low values in winter; with an extreme ratio of 2.5 times between summer and winter seasons for Los Condores mine. The radiation dose and environmental health risk of {sup 222}Rn concentrations to both guides and visitors were estimated for both seasons and compared with dose and action level values recommended by the International Commission on Radiological Protection (ICRP). The radon contribution to the effective dose rate for visitors has been previously assessed for the warm season. The values are 0.38±0.07 mSv y{sup -1} and 0.05±0.02 mSv y{sup -1} for La Carolina and Los Condores, respectively. These values were obtained assuming an accumulated annual time underground of 20 h. For the guides these values are 11±2 mSv y{sup -1} and 1.45±0.5 mSv y{sup -1} for La Carolina and Los Condores, respectively, assuming an accumulated annual time underground of 600 h. The occupational dose rate limit suggested by the ICRP is 20 mSv y{sup -1}. As these values indicate the dose is an order of magnitude lower in Los Condores than La Carolina mine. This is because this mine, due to its characteristics, is more ventilated than La Carolina mine. This is important because actions can be taken to lower the radon accumulation in La Carolina gold mine, for example by opening new ducts to increase air circulation. Finally, in this work, seasonal variations of the dose rate are assessed and
Juegos de palabras y música en El Cortesano de Luis Milán
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Alfonso Colella
Full Text Available Este artículo analiza cómo, en El Cortesano, la música y la actuación musical se ven fuertemente afectadas por el carácter burlesco e ingenioso de todos los personajes que frecuentan las reuniones de Fernando de Aragón y de la reina Germana de Foix. Por lo tanto, el músico Milán, para cumplir con todas las expectativas de este mundo del entretenimiento y del juego, debe basarse necesariamente en una serie de opciones interpretativas que permitan actuaciones rápidas en función de las demandas de su público. Lo que emerge es una imagen del músico y de la música diferente de lo que se esperaría normalmente. En una sociedad de este tipo, no cuenta la música entendida en su estética y aspectos técnicos, sino la capacidad de gestionar las apariencias y someterse a las pruebas y los mandatos impuestos por los rituales del juego cortesano. Tenemos muchos ejemplos en que Milán se muestra con pasividad y sumisión. Pero es normal, porque esto entra en los códigos de la vida de la corte. This article takes into consideration El Cortesano (1561 by Luis Milán: in this text the musical performance is strongly influenced by the playful attitudes of the individuals who attended the court meetings of Fernando de Aragón and Germana de Foix. Therefore, the musician has to keep in mind every expectation of courtly entertainment and gaming, and morevoer he must open his interpretative options to meet also the demands of the public. What emerges is a picture of the musician and his music that is different from what one would expect in another social context. In such aristocratic society as the Duke of Calabria, music was not understood only in terms of its aesthetic values and technical aspects, but it also required that the player accepted the rituals of the courtly game.
Late Miocene-Pleistocene evolution of a Rio Grande rift subbasin, Sunshine Valley-Costilla Plain, San Luis Basin, New Mexico and Colorado
Ruleman, C.A.; Thompson, R.A.; Shroba, R.R.; Anderson, M.; Drenth, B.J.; Rotzien, J.; Lyon, J.
The Sunshine Valley-Costilla Plain, a structural subbasin of the greater San Luis Basin of the northern Rio Grande rift, is bounded to the north and south by the San Luis Hills and the Red River fault zone, respectively. Surficial mapping, neotectonic investigations, geochronology, and geophysics demonstrate that the structural, volcanic, and geomorphic evolution of the basin involves the intermingling of climatic cycles and spatially and temporally varying tectonic activity of the Rio Grande rift system. Tectonic activity has transferred between range-bounding and intrabasin faults creating relict landforms of higher tectonic-activity rates along the mountain-piedmont junction. Pliocene–Pleistocene average long-term slip rates along the southern Sangre de Cristo fault zone range between 0.1 and 0.2 mm/year with late Pleistocene slip rates approximately half (0.06 mm/year) of the longer Quaternary slip rate. During the late Pleistocene, climatic influences have been dominant over tectonic influences on mountain-front geomorphic processes. Geomorphic evidence suggests that this once-closed subbasin was integrated into the Rio Grande prior to the integration of the once-closed northern San Luis Basin, north of the San Luis Hills, Colorado; however, deep canyon incision, north of the Red River and south of the San Luis Hills, initiated relatively coeval to the integration of the northern San Luis Basin.Long-term projections of slip rates applied to a 1.6 km basin depth defined from geophysical modeling suggests that rifting initiated within this subbasin between 20 and 10 Ma. Geologic mapping and geophysical interpretations reveal a complex network of northwest-, northeast-, and north-south–trending faults. Northwest- and northeast-trending faults show dual polarity and are crosscut by north-south– trending faults. This structural model possibly provides an analog for how some intracontinental rift structures evolve through time.
[Fortuitous discovery of gallbladder cancer].
Chiche, L; Metairie, S
The prognosis of gallbladder cancer is basically dependent on the histological stage at diagnosis. In practice, the discovery of a small cancer of the bladder, generally during cholecystectomy give the patient a better care for curative treatment. The advent of laparoscopy has increased the number of cholecstectomies and could increase the frequency of this situation but also raises the difficult problem of metastatic dissemination. In the literature the figures on parietal metastasis after laparoscopy have ranged from 125% to 19%. The median delay to diagnosis of recurrence is 6 months. The cause of this phenomenon (role of the pneumoperitoneum) remains poorly elucidated. Risk factors for the development of a metastasis on the trocar orifice are: rupture of the gallbladder perioperatively and extraction of the gallbladder without protection. It is important to keep in mind this exceptional but serious risk and apply rigorous operative technique. In case of suspected gallbladder we do not advocate laparoscopy. Surgery (hepatectomy, lymphodenectomy, possibly resection of the biliary tract) would be indicted for all stages except pTis and T1a, taking into consideration the localization of the tumor and the patient's general status. It is also classical to recommend resection of the trocar orifices after laparoscopic cholecystectomy. There is a dual challenge today for small-sized gallbladder cancer: improving treatment and avoiding poorer prognosis due to the specific problems raised by laparoscopy.
Recent advances in combinatorial biosynthesis for drug discovery
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Sun H
Full Text Available Huihua Sun,1,* Zihe Liu,1,* Huimin Zhao,1,2 Ee Lui Ang1 1Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, Singapore; 2Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA *These authors contributed equally to this work Abstract: Because of extraordinary structural diversity and broad biological activities, natural products have played a significant role in drug discovery. These therapeutically important secondary metabolites are assembled and modified by dedicated biosynthetic pathways in their host living organisms. Traditionally, chemists have attempted to synthesize natural product analogs that are important sources of new drugs. However, the extraordinary structural complexity of natural products sometimes makes it challenging for traditional chemical synthesis, which usually involves multiple steps, harsh conditions, toxic organic solvents, and byproduct wastes. In contrast, combinatorial biosynthesis exploits substrate promiscuity and employs engineered enzymes and pathways to produce novel "unnatural" natural products, substantially expanding the structural diversity of natural products with potential pharmaceutical value. Thus, combinatorial biosynthesis provides an environmentally friendly way to produce natural product analogs. Efficient expression of the combinatorial biosynthetic pathway in genetically tractable heterologous hosts can increase the titer of the compound, eventually resulting in less expensive drugs. In this review, we will discuss three major strategies for combinatorial biosynthesis: 1 precursor-directed biosynthesis; 2 enzyme-level modification, which includes swapping of the entire domains, modules and subunits, site-specific mutagenesis, and directed evolution; 3 pathway-level recombination. Recent examples of combinatorial biosynthesis employing these
Predicting arsenic concentrations in groundwater of San Luis Valley, Colorado: implications for individual-level lifetime exposure assessment.
James, Katherine A; Meliker, Jaymie R; Buttenfield, Barbara E; Byers, Tim; Zerbe, Gary O; Hokanson, John E; Marshall, Julie A
Consumption of inorganic arsenic in drinking water at high levels has been associated with chronic diseases. Risk is less clear at lower levels of arsenic, in part due to difficulties in estimating exposure. Herein we characterize spatial and temporal variability of arsenic concentrations and develop models for predicting aquifer arsenic concentrations in the San Luis Valley, Colorado, an area of moderately elevated arsenic in groundwater. This study included historical water samples with total arsenic concentrations from 595 unique well locations. A longitudinal analysis established temporal stability in arsenic levels in individual wells. The mean arsenic levels for a random sample of 535 wells were incorporated into five kriging models to predict groundwater arsenic concentrations at any point in time. A separate validation dataset (n = 60 wells) was used to identify the model with strongest predictability. Findings indicate that arsenic concentrations are temporally stable (r = 0.88; 95 % CI 0.83-0.92 for samples collected from the same well 15-25 years apart) and the spatial model created using ordinary kriging best predicted arsenic concentrations (ρ = 0.72 between predicted and observed validation data). These findings illustrate the value of geostatistical modeling of arsenic and suggest the San Luis Valley is a good region for conducting epidemiologic studies of groundwater metals because of the ability to accurately predict variation in groundwater arsenic concentrations.
Disseminating Evidence-Based Physical Education Practices in Rural Schools: The San Luis Valley Physical Education Academy.
Belansky, Elaine S; Cutforth, Nick; Kern, Ben; Scarbro, Sharon
To address childhood obesity, strategies are needed to maximize physical activity during the school day. The San Luis Valley Physical Education Academy was a public health intervention designed to increase the quality of physical education and quantity of moderate to vigorous physical activity (MVPA) during physical education class. Elementary school physical education teachers from 17 schools participated in the intervention. They received SPARK curriculum and equipment, workshops, and site coordinator support for 2 years. A pre/post/post within physical education teacher design was used to measure intervention effectiveness. System for Observing Fitness Instruction Time (SOFIT) and a physical education teacher survey were collected 3 times. MVPA increased from 51.1% to 67.3% over the 2-year intervention resulting in approximately 14.6 additional hours of physical activity over a school year and 4662 kcal or 1.33 lbs. of weight gain prevention. More time was spent on skill drills and less time on classroom management and free play. The San Luis Valley Physical Education Academy succeeded in increasing rural, low-income students' physical activity. The multicomponent intervention contributed to the program's success. However, cost-effective approaches are needed to disseminate and implement evidencebased practices aimed at increasing students' physical activity during the school day.
... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discovery. 406.143 Section 406.143... Transportation Adjudications § 406.143 Discovery. (a) Initiation of discovery. Any party may initiate discovery... after a complaint has been filed. (b) Methods of discovery. The following methods of discovery are...
Causality discovery technology
Chen, M.; Ertl, T.; Jirotka, M.; Trefethen, A.; Schmidt, A.; Coecke, B.; Bañares-Alcántara, R.
Causality is the fabric of our dynamic world. We all make frequent attempts to reason causation relationships of everyday events (e.g., what was the cause of my headache, or what has upset Alice?). We attempt to manage causality all the time through planning and scheduling. The greatest scientific discoveries are usually about causality (e.g., Newton found the cause for an apple to fall, and Darwin discovered natural selection). Meanwhile, we continue to seek a comprehensive understanding about the causes of numerous complex phenomena, such as social divisions, economic crisis, global warming, home-grown terrorism, etc. Humans analyse and reason causality based on observation, experimentation and acquired a priori knowledge. Today's technologies enable us to make observations and carry out experiments in an unprecedented scale that has created data mountains everywhere. Whereas there are exciting opportunities to discover new causation relationships, there are also unparalleled challenges to benefit from such data mountains. In this article, we present a case for developing a new piece of ICT, called Causality Discovery Technology. We reason about the necessity, feasibility and potential impact of such a technology.
Automated Supernova Discovery (Abstract)
Post, R. S.
(Abstract only) We are developing a system of robotic telescopes for automatic recognition of Supernovas as well as other transient events in collaboration with the Puckett Supernova Search Team. At the SAS2014 meeting, the discovery program, SNARE, was first described. Since then, it has been continuously improved to handle searches under a wide variety of atmospheric conditions. Currently, two telescopes are used to build a reference library while searching for PSN with a partial library. Since data is taken every night without clouds, we must deal with varying atmospheric and high background illumination from the moon. Software is configured to identify a PSN, reshoot for verification with options to change the run plan to acquire photometric or spectrographic data. The telescopes are 24-inch CDK24, with Alta U230 cameras, one in CA and one in NM. Images and run plans are sent between sites so the CA telescope can search while photometry is done in NM. Our goal is to find bright PSNs with magnitude 17.5 or less which is the limit of our planned spectroscopy. We present results from our first automated PSN discoveries and plans for PSN data acquisition.
A Technique Socratic Questioning-Guided Discovery
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M. Hakan Türkçapar
Full Text Available "Socratic Method" is a way of teaching philosophical thinking and knowledge by asking questions which was used by antique period greek philosopher Socrates. Socrates was teaching knowledge to his followers by asking questions and the conversation between them was named "Socratic Dialogues". In this meaning, no novel knowledge is taught to the individual but only what is formerly known is reminded and rediscovered. The form of socratic questioning which is used during the process of cognitive behavioral therapy is known as Guided Discovery. In this method it is aimed to make the client notice the piece of knowledge which he could notice but is not aware with a series of questions. Socratic method or guided discovery consists of several steps which are: Identifying the problem by listening to the client and making reflections, finding alternatives by examining and evaluating, reidentification by using the newly found information and questioning the old distorted belief and reaching to a conclusion and applying it. Question types used during these procedures are, questions for gaining information, questions revealing the meanings, questions revealing the beliefs, questions about behaviours during the similar past experiences, analyse questions and analytic synthesis questions. In order to make the patient feel understood it is important to be empathetic and summarising the problem during the interview. In this text, steps of Socratic Questioning-Guided Discovery will be reviewed with sample dialogues after each step
Computational methods in drug discovery
Sumudu P. Leelananda; Steffen Lindert
The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD) tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery project...
Discovery and Selection of Semantic Web Services
Wang, Xia
For advanced web search engines to be able not only to search for semantically related information dispersed over different web pages, but also for semantic services providing certain functionalities, discovering semantic services is the key issue. Addressing four problems of current solution, this book presents the following contributions. A novel service model independent of semantic service description models is proposed, which clearly defines all elements necessary for service discovery and selection. It takes service selection as its gist and improves efficiency. Corresponding selection algorithms and their implementation as components of the extended Semantically Enabled Service-oriented Architecture in the Web Service Modeling Environment are detailed. Many applications of semantic web services, e.g. discovery, composition and mediation, can benefit from a general approach for building application ontologies. With application ontologies thus built, services are discovered in the same way as with single...
Las políticas forestales en el estado de San Luis Potosí en el porfiriato
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Julio César Errejón Gómez
Full Text Available Las acciones y omisiones del presente en materia de política forestal pueden clarificarse si se revisan los antecedentes históricos. Por ello, el objetivo de esta investigación fue analizar la influencia del contexto internacional sobre las políticas forestales implementadas durante el régimen de Porfirio Díaz. Se amplía el panorama sobre las de uso y conservación de los bosques, así como sus repercusiones en San Luis Potosí. Para contextualizar los procesos mencionados, se realizó una consulta exhaustiva de documentos históricos y bibliográficos, y se encontró que el entorno internacional incentivó la creación de leyes e instituciones federales y locales para regular la explotación, el manejo y la conservación de los bosques. A pesar de ello, en esta entidad hubo una reducción importante en sus superficies boscosas; además, el gobierno federal y estatal no evidenció un interés por preservarlas. _______________ Current actions and omissions in forest policy can be clarified if the historical background is reviewed. Therefore, the objective of this research is to analyze the influence of the international context on forest policies implemented during the regime of Porfirio Diaz (1876-1911. In particular, it aims to broaden the outlook on government policies created for the management, use and conservation of forests and their impacts on San Luis Potosi. A thorough consultation of historical and bibliographical documents was made to understand the historical processes. It was found that the international environment encouraged the creation of laws, regulations and federal and local institutions for the purpose of regulating the exploitation, management and conservation of forests. However, the state of San Luis Potosi experienced a significant reduction in their forest areas; in addition, the federal and state governments showed no interest in applying conservation of forests in Potosi territory.
Sm-Nd, Rb-Sr and K-Ar age constraints of the El Molle and Barroso plutons, western Sierra de San Luis, Argentina
International Nuclear Information System (INIS)
Sato, A.M.; Gonzalez, P.D; Petronilho, L.A; Llambias, E.J.; Varela, R; Basei, M.A.S
Within the Early Paleozoic Famatinian orogeny of Southern Sierras Pampeanas (Sierra de San Luis and Sierra de Cordoba), the post-orogenic granitoids are characterized by circular intrusions. The published Rb-Sr and K-Ar ages from plutons in the Sierra de San Luis range between 408 and 320 Ma (see synthesis in Llambias et al., 1998). The El Molle and Barroso plutons (Sims et al., 1997; Gonzalez and Sato, 2000) are the two main exposures of a post-orogenic intrusive complex located in the western area of the Sierra de San Luis basement. They also exhibit an overall circular map view of almost 8 km in diameter, and are emplaced in a metamorphic complex developed through pre-Famatinian (Proterozoic? to Early Paleozoic) to Famatinian (Early Paleozoic) orogenies (Gonzalez and Llambias, 1998; von Gosen and Prozzi, 1998). We are carrying out isotopic datings of the El Molle and Barroso plutons in order to contribute to the understanding of the magmatic and metamorphic evolution of the final stages of the Famatinian orogenic cycle in the Sierra de San Luis. The first results of the Sm-Nd, Rb-Sr and K-Ar dates are here presented (au)
A New Destination for "The Flying Bus"?: The Implications of Orlando-Rican Migration for Luis Rafael Sanchez's "La guagua aerea"
Barreneche, Gabriel Ignacio; Lombardi, Jane; Ramos-Flores, Hector
Puerto Rican author Luis Rafael Sanchez's "La guagua aerea" explores the duality, hybridity, and fluidity of US-Puerto Rican identity through the frequent travel of migrants between New York City (the traditional destination city for Puerto Rican migrants) and the island. In recent years, however, the "flying bus" has adopted a…
Hippocampus discovery First steps
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Eliasz Engelhardt
Full Text Available The first steps of the discovery, and the main discoverers, of the hippocampus are outlined. Arantius was the first to describe a structure he named "hippocampus" or "white silkworm". Despite numerous controversies and alternate designations, the term hippocampus has prevailed until this day as the most widely used term. Duvernoy provided an illustration of the hippocampus and surrounding structures, considered the first by most authors, which appeared more than one and a half century after Arantius' description. Some authors have identified other drawings and texts which they claim predate Duvernoy's depiction, in studies by Vesalius, Varolio, Willis, and Eustachio, albeit unconvincingly. Considering the definition of the hippocampal formation as comprising the hippocampus proper, dentate gyrus and subiculum, Arantius and Duvernoy apparently described the gross anatomy of this complex. The pioneering studies of Arantius and Duvernoy revealed a relatively small hidden formation that would become one of the most valued brain structures.
Reading the Other Side of the Story: Ominous Voice and the Sociocultural and Political Implications of Luis Spota's Murieron a mitad del río
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Francisco Manzo-Robledo
Full Text Available It is always contoversial to proclaim a literary work, at face value, as a sociocultural study of a particular society. It is even more controversial when one deals with a hybrid work, combining factors from two completely distinct societies. Yet, there are some literary works that seem to call for exactly this type of analysis, presenting a range of ideas which in retrospect reveal origins of significant sociocultural trends. Such is the case of Luis Spota's Murieron a mitad del río (1948. This novel presents a panorama of ancestral problems in the life of thousands of immigrants and inhabitants of the Mexican-U.S. border region trying to achieve a "better life for them and their children," yet forced to live in social limbo. These individuals reside neither entirely in Mexico nor in the United States, but in a place where the existence of tensions started with the competition for jobs amongst the "already in" and the "newly arrived" (regardless of the legal status augmenting the differences created by a new environment. Although only implicitly present in the novel, some of these problems are approached from a legal point of view creating, contrary to their intended purpose, a better means for the selection of immigrant manual labor. Although not in the novel, a case in point would be the new "walls of ignominy" along the Tijuana-San Diego crossing, where undocumented migration has shifted east toward Calexico and other parts of the Arizona desert. Since conditions to cross the border there illegally are more rigorous, only the young and strong dare to do it. This essay examines the manner Spota uses to expose his particularly "urban" point of view and a set of social problems, from a cultural theory point of analysis. It demonstates that Murieron a mitad del río presents a microcosm of the issue and in a way, predicts some of the main dilemmas that both countries will encounter through the years. Thus, Spota becomes a visionary, dealing in
TECNOLOGÍA LÍTICA Y USO DIFERENCIAL DEL ESPACIO EN ESTANCIA LA SUIZA, SAN LUIS, ARGENTINA / Lithic technology and differential use of space in Estancia La Suiza, San Luis, Argentina
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Gisela Sario
Full Text Available El trabajo pretende contribuir, desde la perspectiva de la organización de la tecnología, al conocimiento de las ocupaciones cazadoras-recolectoras que habitaron las inmediaciones de la Sierra de la Estanzuela, en la provincia de San Luis, Argentina. Se explican cómo fueron las secuencias de producción de herramientas en los sitios de la localidad arqueológica Estancia La Suiza, a partir del análisis de los materiales líticos recuperados en excavación y prospecciones sistemáticas. Las metodologías propuestas para abordar este estudio corresponden al análisis nodular y más específicamente a una combinación del análisis tipológico y no tipológico. Los resultados permiten interpretar que en esta localidad hubo un uso diferencial del espacio, particularmente en dos sitios que son Estancia La Suiza 2 y Estancia La Suiza 3. Abstract This paper aims at gaining insight, from the angle of technological organization, into the hunter-gatherer communities that dwelled in the surrounding areas of Sierras de la Estanzuela, in the province of San Luis, Argentina. The sequence of tool development in the archaeological site of Estancia La Suiza is described from analysis of lithic materials from excavation and systematic surveys. The methods adopted for conducting this study form part of Minimal Nodule analysis (MANA and more specifically a combination of typological and non-typological analysis. Results indicate that this site evidences a differential use of space, more specifically found in Estancia La Suiza 2 and Estancia La Suiza 3.
Knowledge Discovery from Vibration Measurements
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Jun Deng
Full Text Available The framework as well as the particular algorithms of pattern recognition process is widely adopted in structural health monitoring (SHM. However, as a part of the overall process of knowledge discovery from data bases (KDD, the results of pattern recognition are only changes and patterns of changes of data features. In this paper, based on the similarity between KDD and SHM and considering the particularity of SHM problems, a four-step framework of SHM is proposed which extends the final goal of SHM from detecting damages to extracting knowledge to facilitate decision making. The purposes and proper methods of each step of this framework are discussed. To demonstrate the proposed SHM framework, a specific SHM method which is composed by the second order structural parameter identification, statistical control chart analysis, and system reliability analysis is then presented. To examine the performance of this SHM method, real sensor data measured from a lab size steel bridge model structure are used. The developed four-step framework of SHM has the potential to clarify the process of SHM to facilitate the further development of SHM techniques.
Using directed information for influence discovery in interconnected dynamical systems
Rao, Arvind; Hero, Alfred O.; States, David J.; Engel, James Douglas
Structure discovery in non-linear dynamical systems is an important and challenging problem that arises in various applications such as computational neuroscience, econometrics, and biological network discovery. Each of these systems have multiple interacting variables and the key problem is the inference of the underlying structure of the systems (which variables are connected to which others) based on the output observations (such as multiple time trajectories of the variables). Since such applications demand the inference of directed relationships among variables in these non-linear systems, current methods that have a linear assumption on structure or yield undirected variable dependencies are insufficient. Hence, in this work, we present a methodology for structure discovery using an information-theoretic metric called directed time information (DTI). Using both synthetic dynamical systems as well as true biological datasets (kidney development and T-cell data), we demonstrate the utility of DTI in such problems.
Un omaggio a Giuseppe Bellini attraverso un libro a lui dedicato: cuando quiero hallar las voces, encuentro con los afectos...
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Emilia Perassi
Full Text Available Il presente articolo si propone di tracciare il ritratto di uno dei grandi maestri di studi ispanoamericanistici, Giuseppe Bellini, attraverso una recente opera miscellanea a lui dedicata, a cura di Patrizia Spinato Bruschi e Jaime Martínez. Tale raccolta di saggi non solo restituisce le linee, i contenuti e le forme di una produzione critica monumentale ma ben mostra l'importante ruolo di studioso e di uomo che il Bellini è stato capace di esercitare, articolando attorno a sé una nutrita scuola, a partire dalla visione della letteratura come rete di dialogo e di scambio. I diversi temi affrontati dai più di cinquantacinque saggi mostrano la straordinaria capacità del Bellini di tessere una proficua rete di relazioni, di studio e di amicizia, e di promuovere l'ispanoamericanismo italiano, sempre attraverso il riconoscimento della letteratura come lezione civile e del buon vivere.
Perception of the general population in Ciudad Valles, San Luis Potosi regarding waste production in hairdressing salons
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Juan José Maldonado-Miranda
Full Text Available Hairdressing salons offer a wide range of services including treatments for hair and skin. However, these activities result in the production of residues that are improperly discharged into drainage, generating a negative impact on the environment. This study provides results of a first stage in a project regarding the analysis of waste disposal in hairdressing salons in the municipality of Ciudad Valles, San Luis Potosi, Mexico. Information gathering was conducted through a field work study by surveys given to workers in hairdressing salons in Ciudad Valles. The information presented in this study indicates that in hairdressing salons in Ciudad Valles there is no management plan for the management of waste that could be severely impacting the environment. The information presented here will be the basis for identifying priority areas for intervention, developing new research projects and setting new environmental policies. In addition, the results presented here can be extrapolated to many rural and urban areas all over Mexico.
Dual electricity generation biogas-diesel in the community of Maguey, municipality of San Luis. Santiago de Cuba
International Nuclear Information System (INIS)
Recio Recio, Angel Amado; Palacios Barrera, Antonio; Salas Diaz, Alberto; Bertot, Romulo; Garcia Faure, Luis
The work was developed in the rural community Magueyal, Popular Council Chamarreta of the Municipality San Luis, Santiago de Cuba province, consisting of 198 inhabitants, distributed in 75 of these 64 homes have electricity, also has a primary school and a medical clinic family. Its main activity is livestock to be located in a place where the topography is very steep, leading to not develop infrastructure networks. The electricity was supplied by diesel engine MWM-DITER, Type: D 327-2 and the supply of electricity was only 4 hours a day; it was decided to take him to eight hours using biogas, thus saving fuel. For this purposes and with funding from an international project proceeded to construction of two biogas digesters 83.04 m3 and 91.26 m3 of total volume, respectively, with which the generator feeds two reducing diesel consumption by 75% and increasing the hours of supply electricity for 4-8 hours. (author)
On the Shores of the Revolution: Martín Luis Guzmán in Madrid (1915
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Susana Quintanilla
Full Text Available 1915 is considered a decisive year in world history. Underneath wartime plundering, eighteenth-century beliefs in social progress and human civilization collapsed, and other political and philosophical credos sprouted, while aesthetic avant-gardes created new forms of artistic and literary expression. That same year, from his exile in Madrid, Martín Luis Guzmán would define the coordinates that would guide his life, while trying to assimilate his recent experiences during the Mexican Revolution and make way as a writer, under the immediate protection of Alfonso Reyes and the far-away but determining one of Pedro Henríquez Ureña. Without abandoning his political vocation and remaining open to new trends, Guzmán drew up his own path, which would lead him alongside his mentors and to the forefront of literature in Spanish.
Real-Time Water Quality Monitoring and Habitat Assessment in theSan Luis National Wildlife Refuge
Energy Technology Data Exchange (ETDEWEB)
Quinn, Nigel W.T.; Hanlon, Jeremy S.; Burns, Josephine R.; Stromayer, Karl A.K.; Jordan, Brandon M.; Ennis, Mike J.; Woolington,Dennis W.
The project report describes a two year experiment to control wetland drainage to the San Joaquin River of California from the San Luis National Wildlife Refuge using a decision support system for real-time water quality management. This system required the installation and operation of one inlet and three drainage flow and water quality monitoring stations which allowed a simple mass balance model to be developed of the seasonally managed wetlands in the study area. Remote sensing methods were developed to document long-term trends in wetland moist soil vegetation and soil salinity in response to management options such as delaying the initiation of seasonal wetland drainage. These environmental management tools provide wetland managers with some of the tools necessary to improve salinity conditions in the San Joaquin River and improve compliance with State mandated salinity objectives without inflicting long-term harm on the wild fowl habitat resource.
La reescritura de La infancia en Los días ocultos de Luis Oyarzún
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Lorena Amaro Castro
Full Text Available El filósofo Luis Oyarzún escribió dos novelas de carácter autobiográfico en que presenta las percepciones de un niño de provincia: La infancia (1940 y Los días ocultos (1955. Críticos como Roberto Hozven, Leonidas Morales y Olga Grau manifiestan que la segunda es una reelaboración de la primera. El siguiente artículo desarrolla una comparación entre ambos textos, buscando dilucidar y comprender cuáles son las diferencias entre ellos y en qué medida revelan una maduración en la escritura e inquietudes de un autor que ocupa un lugar hasta ahora marginal en la construcción canónica filosófica y literaria chilena.
Materials Discovery | Materials Science | NREL
Discovery Materials Discovery Images of red and yellow particles NREL's research in materials characterization of sample by incoming beam and measuring outgoing particles, with data being stored and analyzed Staff Scientist Dr. Zakutayev specializes in design of novel semiconductor materials for energy
Service discovery using Bloom filters
Goering, P.T.H.; Heijenk, Geert; Lelieveldt, B.P.F.; Haverkort, Boudewijn R.H.M.; de Laat, C.T.A.M.; Heijnsdijk, J.W.J.
A protocol to perform service discovery in adhoc networks is introduced in this paper. Attenuated Bloom filters are used to distribute services to nodes in the neighborhood and thus enable local service discovery. The protocol has been implemented in a discrete event simulator to investigate the
What started 50 years ago as a `smudge' on paper has flourished into a fundamental field of astrophysics replete with unexpected applications and exciting discoveries. To celebrate the discovery of pulsars, we look at the past, present and future of pulsar astrophysics.
[Future status of ischaemic heart disease in the state of San Luis Potosí: A predictive dynamic model].
Gaytán-Hernández, Darío; Díaz-Oviedo, Aracely; Gallegos-García, Verónica; Terán-Figueroa, Yolanda
To develop a predictive dynamic model to generate and analyse the future status of the incidence rate of ischaemic heart disease in a population of 25 years and over in Mexico, according to the variation in time of some risk factors. Retrospective ecological study performed during the period 2013-2015, in San Luis Potosí City, Mexico. Secondary databases that corresponded to the years 2000, 2005, and 2010, were used along with official indicators of the 58 municipalities of the state of San Luis Potosí. Eight indicators were analysed at municipality level, using principal components analysis, structural equation modelling, dynamic modelling, and simulation software methods. Three components were extracted, which together explained 80.43% of the total variance of the official indicators used. The second component had a weight of 16.36 units that favoured an increase of the disease analysed. This component was integrated only by the indicator AGE 60-64 and the expected stage of it increasing. The structural model confirmed that the indicators explain 42% of the variation of this disease. The possible stages for the years 2015, 2020, and 2025 are 195.7, 240.7, and 298.0, respectively for every 100,000 inhabitants aged 25 and over. An exponential increase in the incidence rate of ischaemic heart disease is expected, with the age of 60-64 years being identified as the highest risk factor. Copyright © 2017 Instituto Nacional de Cardiología Ignacio Chávez. Publicado por Masson Doyma México S.A. All rights reserved.
Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico
Comas‐García, Andreu; García‐Sepúlveda, Christian A.; Méndez‐de Lira, José J.; Aranda‐Romo, Saray; Hernández‐Salinas, Alba E.; Noyola, Daniel E.
Please cite this paper as: Comas‐García et al. (2011) Mortality attributable to pandemic influenza A (H1N1) 2009 in San Luis Potosí, Mexico. Influenza and Other Respiratory Viruses 5(2), 76–82. Background Acute respiratory infections are a leading cause of morbidity and mortality worldwide. Starting in 2009, pandemic influenza A(H1N1) 2009 virus has become one of the leading respiratory pathogens worldwide. However, the overall impact of this virus as a cause of mortality has not been clearly defined. Objectives To determine the impact of pandemic influenza A(H1N1) 2009 on mortality in a Mexican population. Methods We assessed the impact of pandemic influenza virus on mortality during the first and second outbreaks in San Luis Potosí, Mexico, and compared it to mortality associated with seasonal influenza and respiratory syncytial virus (RSV) during the previous winter seasons. Results We estimated that, on average, 8·1% of all deaths that occurred during the 2003–2009 seasons were attributable to influenza and RSV. During the first pandemic influenza A(H1N1) 2009 outbreak, there was an increase in mortality in persons 5–59 years of age, but not during the second outbreak (Fall of 2009). Overall, pandemic influenza A (H1N1) 2009 outbreaks had similar effects on mortality to those associated with seasonal influenza virus epidemics. Conclusions The impact of influenza A(H1N1) 2009 virus on mortality during the first year of the pandemic was similar to that observed for seasonal influenza. The establishment of real‐time surveillance systems capable of integrating virological, morbidity, and mortality data may result in the timely identification of outbreaks so as to allow for the institution of appropriate control measures to reduce the impact of emerging pathogens on the population. PMID:21306570
Archosauriform remains from the Late Triassic of San Luis province, Argentina, Quebrada del Barro Formation, Marayes-El Carrizal Basin
Gianechini, Federico A.; Codorniú, Laura; Arcucci, Andrea B.; Castillo Elías, Gabriela; Rivarola, David
Here we present archosauriform remains from 'Abra de los Colorados', a fossiliferous locality at Sierra de Guayaguas, NW San Luis Province. Two fossiliferous levels were identified in outcrops of the Quebrada del Barro Formation (Norian), which represent the southernmost outcrops of the Marayes-El Carrizal Basin. These levels are composed by massive muddy lithofacies, interpreted as floodplain deposits. The specimens consist of one incomplete maxilla (MIC-V718), one caudal vertebra (MIC-V719), one metatarsal (MIC-V720) and one indeterminate appendicular bone (MIC-V721). The materials can be assigned to Archosauriformes but the fragmentary nature and lack of unambiguous synapomorphies preclude a more precise taxomic assignment. The maxilla is remarkably large and robust and represents the posterior process. It preserved one partially erupted tooth with ziphodont morphology. This bone shows some anatomical traits and size match with 'rauisuchians' and theropods. MIC-V719 corresponds to a proximal caudal vertebra. It has a high centrum, a ventral longitudinal furrow, expanded articular processes for the chevrons, a posteriorly displaced diapophysis located below the level of the prezygapophyses, and short prezygapophyses. This vertebra would be from an indeterminate archosauriform. MIC-V720 presents a cylindrical diaphysis, with a well-developed distal trochlea, which present resemblances with metatarsals of theropods, pseudosuchians, and silesaurids, although the size matches better with theropods. MIC-V721 has a slender diaphysis and a convex triangular articular surface, and corresponds to an indeterminate archosauriform. Despite being fragmentary, these materials indicate the presence of a diverse archosauriforms association from Late Triassic beds of San Luis. Thus, they add to the faunal assemblage recently reported from this basin at San Juan Province, which is much rich and diverse than the coeval paleofauna well known from Los Colorados Formation in the
Encefalitis por virus San Luis en la Ciudad de Buenos Aires durante el brote de dengue 2009
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Horacio López
Full Text Available Se presenta un paciente de 80 años de edad, residente en la Ciudad de Buenos Aires, con diagnóstico serológico para el virus de la encefalitis de San Luis (SLE durante el brote de dengue ocurrido entre enero y mayo de 2009. Presentaba leucemia linfoide crónica en tratamiento con clorambucilo, cáncer de próstata tratado con hormonoterapia y radioterapia, e imágenes óseas compatibles con metástasis. El estudio del líquido cefalorraquídeo demostró pleocitosis con predominio de mononucleares y proteinorraquia elevada. El resultado de los cultivos para bacterias, hongos y micobacterias, así como el PCR en LCR para herpes virus, HSV, CMV y EBV, fue negativo. Se detectaron anticuerpos IgM para virus SLE tanto en LCR como en muestra de suero, con seroconversión IgG por neutralización en cultivos celulares y resultados negativos para los demás Flavivirus con circulación en Argentina. Se revisan evidencias sobre la presencia de virus de San Luis en nuestro país, y se señala la importancia de la confirmación diagnóstica y el estudio de otros Flavivirus en casos sospechosos de dengue con presentación grave o atípica. Este trabajo remarca la necesidad de fortalecer tanto la vigilancia epidemiológica del virus SLE, como el control vectorial para prevenir las diferentes infecciones transmitidas por mosquitos y conocer su efecto en Salud Pública en la Argentina.
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
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Nicholas Ekow Thomford
Full Text Available The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of "active compound" has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of 'organ-on chip' and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.
Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred; Dzobo, Kevin
The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. There are however a lot of global health challenges with diseases such as cancer, degenerative diseases, HIV/AIDS and diabetes, of which modern medicine is struggling to provide cures. Many times the isolation of "active compound" has made the compound ineffective. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. The advent of latest technologies that enhance drug design hypotheses such as Artificial Intelligence, the use of 'organ-on chip' and microfluidics technologies, means that automation has become part of drug discovery. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds. Recent advances in analytical and computational techniques have opened new avenues to process complex natural products and to use their structures to derive new and innovative drugs. Indeed, we are in the era of computational molecular design, as applied to natural products. Predictive computational softwares have contributed to the discovery of molecular targets of natural products and their derivatives. In future the use of quantum computing, computational softwares and databases in modelling molecular interactions and predicting features and parameters needed for drug development, such as pharmacokinetic and pharmacodynamics, will result in few false positive leads in drug development. This review
Discovery and development of new antibacterial drugs: learning from experience?
Jackson, Nicole; Czaplewski, Lloyd; Piddock, Laura J V
Antibiotic (antibacterial) resistance is a serious global problem and the need for new treatments is urgent. The current antibiotic discovery model is not delivering new agents at a rate that is sufficient to combat present levels of antibiotic resistance. This has led to fears of the arrival of a 'post-antibiotic era'. Scientific difficulties, an unfavourable regulatory climate, multiple company mergers and the low financial returns associated with antibiotic drug development have led to the withdrawal of many pharmaceutical companies from the field. The regulatory climate has now begun to improve, but major scientific hurdles still impede the discovery and development of novel antibacterial agents. To facilitate discovery activities there must be increased understanding of the scientific problems experienced by pharmaceutical companies. This must be coupled with addressing the current antibiotic resistance crisis so that compounds and ultimately drugs are delivered to treat the most urgent clinical challenges. By understanding the causes of the failures and successes of the pharmaceutical industry's research history, duplication of discovery programmes will be reduced, increasing the productivity of the antibiotic drug discovery pipeline by academia and small companies. The most important scientific issues to address are getting molecules into the Gram-negative bacterial cell and avoiding their efflux. Hence screening programmes should focus their efforts on whole bacterial cells rather than cell-free systems. Despite falling out of favour with pharmaceutical companies, natural product research still holds promise for providing new molecules as a basis for discovery.
29 CFR 2700.56 - Discovery; general.
...(c) or 111 of the Act has been filed. 30 U.S.C. 815(c) and 821. (e) Completion of discovery... 29 Labor 9 2010-07-01 2010-07-01 false Discovery; general. 2700.56 Section 2700.56 Labor... Hearings § 2700.56 Discovery; general. (a) Discovery methods. Parties may obtain discovery by one or more...
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 207.109 Section 207.109 Customs Duties... and Committee Proceedings § 207.109 Discovery. (a) Discovery methods. All parties may obtain discovery under such terms and limitations as the administrative law judge may order. Discovery may be by one or...
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Discovery. 44.24 Section 44.24 Mineral... Discovery. Parties shall be governed in their conduct of discovery by appropriate provisions of the Federal... discovery. Alternative periods of time for discovery may be prescribed by the presiding administrative law...
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 356.20 Section 356.20 Customs Duties... § 356.20 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery... sanctions proceeding. (b) Limitations on discovery. The administrative law judge shall place such limits...
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 180.500 Section 180.500... OPPORTUNITY CONSOLIDATED HUD HEARING PROCEDURES FOR CIVIL RIGHTS MATTERS Discovery § 180.500 Discovery. (a) In general. This subpart governs discovery in aid of administrative proceedings under this part. Discovery in...
... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discovery. 25.21 Section 25.21... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for..., discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery. (d...
... 39 Postal Service 1 2010-07-01 2010-07-01 false Discovery. 963.14 Section 963.14 Postal Service... PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.14 Discovery. Discovery is to be conducted on a... such discovery as he or she deems reasonable and necessary. Discovery may include one or more of the...
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 224.21 Section 224.21 Foreign....21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of... parties, discovery is available only as ordered by the ALJ. The ALJ shall regulate the timing of discovery...
Discovery Mondays: Surveyors' Tools
Surveyors of all ages, have your rulers and compasses at the ready! This sixth edition of Discovery Monday is your chance to learn about the surveyor's tools - the state of the art in measuring instruments - and see for yourself how they work. With their usual daunting precision, the members of CERN's Surveying Group have prepared some demonstrations and exercises for you to try. Find out the techniques for ensuring accelerator alignment and learn about high-tech metrology systems such as deviation indicators, tracking lasers and total stations. The surveyors will show you how they precisely measure magnet positioning, with accuracy of a few thousandths of a millimetre. You can try your hand at precision measurement using different types of sensor and a modern-day version of the Romans' bubble level, accurate to within a thousandth of a millimetre. You will learn that photogrammetry techniques can transform even a simple digital camera into a remarkable measuring instrument. Finally, you will have a chance t...
Network-based discovery through mechanistic systems biology. Implications for applications--SMEs and drug discovery: where the action is.
Benson, Neil
Phase II attrition remains the most important challenge for drug discovery. Tackling the problem requires improved understanding of the complexity of disease biology. Systems biology approaches to this problem can, in principle, deliver this. This article reviews the reports of the application of mechanistic systems models to drug discovery questions and discusses the added value. Although we are on the journey to the virtual human, the length, path and rate of learning from this remain an open question. Success will be dependent on the will to invest and make the most of the insight generated along the way. Copyright © 2015 Elsevier Ltd. All rights reserved.
Indian Academy of Sciences (India)
Even later , being mostly self-driven has helped me treat any obstacle in my career as a temporary problem. Doing a Ph.D. in the United States, brought new oppor- tunities and encouraged an openness to things, and most impor- tantly the necessity of steady, dedicated, hard work for a scientist. There, I also met Aloke Jain, ...
'The Lusiads', poem of discovery
Directory of Open Access Journals (Sweden)
Natasha Furlan Felizi
Full Text Available The article proposes reading Os Lusíadas as a discovery journey. Discovery here read as aletheia or "revelation", as proposed by Sophia de Mello Breyner Andresen in 1980. Using Martin Heidegger's notion of aletheia in the book Parmenides along with Jorge de Sena and Sophia de Mello Breyner Andresen reflections on Camões, I'll seek to point out alternative readings for Os Lusíadas as a "discovery journey".
Discovery of natural resources
Guild, P.W.
Mankind will continue to need ores of more or less the types and grades used today to supply its needs for new mineral raw materials, at least until fusion or some other relatively cheap, inexhaustible energy source is developed. Most deposits being mined today were exposed at the surface or found by relatively simple geophysical or other prospecting techniques, but many of these will be depleted in the foreseeable future. The discovery of deeper or less obvious deposits to replace them will require the conjunction of science and technology to deduce the laws that governed the concentration of elements into ores and to detect and evaluate the evidence of their whereabouts. Great theoretical advances are being made to explain the origins of ore deposits and understand the general reasons for their localization. These advances have unquestionable value for exploration. Even a large deposit is, however, very small, and, with few exceptions, it was formed under conditions that have long since ceased to exist. The explorationist must suppress a great deal of "noise" to read and interpret correctly the "signals" that can define targets and guide the drilling required to find it. Is enough being done to ensure the long-term availability of mineral raw materials? The answer is probably no, in view of the expanding consumption and the difficulty of finding new deposits, but ingenuity, persistence, and continued development of new methods and tools to add to those already at hand should put off the day of "doing without" for many years. The possibility of resource exhaustion, especially in view of the long and increasing lead time needed to carry out basic field and laboratory studies in geology, geophysics, and geochemistry and to synthesize and analyze the information gained from them counsels against any letting down of our guard, however (17). Research and exploration by government, academia, and industry must be supported and encouraged; we cannot wait until an eleventh
Supernovae Discovery Efficiency
John, Colin
Abstract:We present supernovae (SN) search efficiency measurements for recent Hubble Space Telescope (HST) surveys. Efficiency is a key component to any search, and is important parameter as a correction factor for SN rates. To achieve an accurate value for efficiency, many supernovae need to be discoverable in surveys. This cannot be achieved from real SN only, due to their scarcity, so fake SN are planted. These fake supernovae—with a goal of realism in mind—yield an understanding of efficiency based on position related to other celestial objects, and brightness. To improve realism, we built a more accurate model of supernovae using a point-spread function. The next improvement to realism is planting these objects close to galaxies and of various parameters of brightness, magnitude, local galactic brightness and redshift. Once these are planted, a very accurate SN is visible and discoverable by the searcher. It is very important to find factors that affect this discovery efficiency. Exploring the factors that effect detection yields a more accurate correction factor. Further inquires into efficiency give us a better understanding of image processing, searching techniques and survey strategies, and result in an overall higher likelihood to find these events in future surveys with Hubble, James Webb, and WFIRST telescopes. After efficiency is discovered and refined with many unique surveys, it factors into measurements of SN rates versus redshift. By comparing SN rates vs redshift against the star formation rate we can test models to determine how long star systems take from the point of inception to explosion (delay time distribution). This delay time distribution is compared to SN progenitors models to get an accurate idea of what these stars were like before their deaths.
RAS - Screens & Assays - Drug Discovery
The RAS Drug Discovery group aims to develop assays that will reveal aspects of RAS biology upon which cancer cells depend. Successful assay formats are made available for high-throughput screening programs to yield potentially effective drug compounds.
Antibody informatics for drug discovery
DEFF Research Database (Denmark)
Shirai, Hiroki; Prades, Catherine; Vita, Randi
to the antibody science in every project in antibody drug discovery. Recent experimental technologies allow for the rapid generation of large-scale data on antibody sequences, affinity, potency, structures, and biological functions; this should accelerate drug discovery research. Therefore, a robust bioinformatic...... infrastructure for these large data sets has become necessary. In this article, we first identify and discuss the typical obstacles faced during the antibody drug discovery process. We then summarize the current status of three sub-fields of antibody informatics as follows: (i) recent progress in technologies...... for antibody rational design using computational approaches to affinity and stability improvement, as well as ab-initio and homology-based antibody modeling; (ii) resources for antibody sequences, structures, and immune epitopes and open drug discovery resources for development of antibody drugs; and (iii...
Discovery of the iron isotopes
International Nuclear Information System (INIS)
Schuh, A.; Fritsch, A.; Heim, M.; Shore, A.; Thoennessen, M.
Twenty-eight iron isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.
Discovery of the silver isotopes
International Nuclear Information System (INIS)
Schuh, A.; Fritsch, A.; Ginepro, J.Q.; Heim, M.; Shore, A.; Thoennessen, M.
Thirty-eight silver isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.
Synthetic biology of antimicrobial discovery
Zakeri, Bijan; Lu, Timothy K.
Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore, used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery. PMID:23654251
Discovery of the cadmium isotopes
International Nuclear Information System (INIS)
Amos, S.; Thoennessen, M.
Thirty-seven cadmium isotopes have been observed so far and the discovery of these isotopes is discussed here. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.
Discoveries of isotopes by fission
Indian Academy of Sciences (India)
country of discovery as well as the production mechanism used to produce the isotopes. ... the disintegration products of bombarded uranium, as a consequence of a ..... advanced accelerator and newly developed separation and detection ...
Synthetic biology of antimicrobial discovery.
Zakeri, Bijan; Lu, Timothy K
Antibiotic discovery has a storied history. From the discovery of penicillin by Sir Alexander Fleming to the relentless quest for antibiotics by Selman Waksman, the stories have become like folklore used to inspire future generations of scientists. However, recent discovery pipelines have run dry at a time when multidrug-resistant pathogens are on the rise. Nature has proven to be a valuable reservoir of antimicrobial agents, which are primarily produced by modularized biochemical pathways. Such modularization is well suited to remodeling by an interdisciplinary approach that spans science and engineering. Herein, we discuss the biological engineering of small molecules, peptides, and non-traditional antimicrobials and provide an overview of the growing applicability of synthetic biology to antimicrobials discovery.
The discovery of 'heavy light'
International Nuclear Information System (INIS)
The history of the discoveries of fundamental quanta is described starting from Maxwell's theory of electromagnetism up to the development of a theory of weak interaction and the detection of the W and Z bosons. (HSI).
Discovery – Development of Rituximab
NCI funded the development of rituximab, one of the first monoclonal antibody cancer treatments. With the discovery of rituximab, more than 70 percent of patients diagnosed with non-hodgkin lymphoma now live five years past their initial diagnosis.
Discovery of Paradigm Dependencies
Sun, Jizhou; Li, Jianzhong; Gao, Hong
Missing and incorrect values often cause serious consequences. To deal with these data quality problems, a class of common employed tools are dependency rules, such as Functional Dependencies (FDs), Conditional Functional Dependencies (CFDs) and Edition Rules (ERs), etc. The stronger expressing ability a dependency has, data with the better quality can be obtained. To the best of our knowledge, all previous dependencies treat each attribute value as a non-splittable whole. Actually however, i...
Radioactivity. Centenary of radioactivity discovery
International Nuclear Information System (INIS)
Charpak, G.; Tubiana, M.; Bimbot, R.
This small booklet was edited for the occasion of the exhibitions of the celebration of the centenary of radioactivity discovery which took place in various locations in France from 1996 to 1998. It recalls some basic knowledge concerning radioactivity and its applications: history of discovery, atoms and isotopes, radiations, measurement of ionizing radiations, natural and artificial radioactivity, isotope dating and labelling, radiotherapy, nuclear power and reactors, fission and fusion, nuclear wastes, dosimetry, effects and radioprotection. (J.S.)
Computational methods in drug discovery
Directory of Open Access Journals (Sweden)
Sumudu P. Leelananda
Full Text Available The process for drug discovery and development is challenging, time consuming and expensive. Computer-aided drug discovery (CADD tools can act as a virtual shortcut, assisting in the expedition of this long process and potentially reducing the cost of research and development. Today CADD has become an effective and indispensable tool in therapeutic development. The human genome project has made available a substantial amount of sequence data that can be used in various drug discovery projects. Additionally, increasing knowledge of biological structures, as well as increasing computer power have made it possible to use computational methods effectively in various phases of the drug discovery and development pipeline. The importance of in silico tools is greater than ever before and has advanced pharmaceutical research. Here we present an overview of computational methods used in different facets of drug discovery and highlight some of the recent successes. In this review, both structure-based and ligand-based drug discovery methods are discussed. Advances in virtual high-throughput screening, protein structure prediction methods, protein–ligand docking, pharmacophore modeling and QSAR techniques are reviewed.
Get Involved in Planetary Discoveries through New Worlds, New Discoveries
Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA
"New Worlds, New Discoveries" is a synthesis of NASA's 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun's family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site's event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to
Data Science and Optimal Learning for Material Discovery and Design
; Optimal Learning for Material Discovery & Design Data Science and Optimal Learning for Material inference and optimization methods that can constrain predictions using insights and results from theory directions in the application of information theoretic tools to materials problems related to learning from
Reinventing Discovery Learning: A Field-Wide Research Program
Abrahamson, Dor; Kapur, Manu
Whereas some educational designers believe that students should learn new concepts through explorative problem solving within dedicated environments that constrain key parameters of their search and then support their progressive appropriation of empowering disciplinary forms, others are critical of the ultimate efficacy of this discovery-based…
Petrological and geochemical characterization of the plutonic rocks of the Sierra de La Aguada, Province of San Luis, Argentina: Genetic implications with the Famatinian magmatic arc
Directory of Open Access Journals (Sweden)
E. Cristofolini
Full Text Available This study presents a synthesis on the geology of the crystalline complex that constitute the Sierra de la Aguada, San Luis province, Argentine, from an approach based on field relations, petrologic and structural features and geochemical characteristic. This mountain range exposes a basement dominated by intermediate to mafic calcalkaline igneous rocks and peraluminous felsic granitoids, both emplaced in low to medium grade metamorphic rocks stabilized under low amphibolite facies. All this lithological terrane has been grouped in the El Carrizal-La Aguada Complex. Field relations, petrographic characterization and geochemical comparison of the plutonic rocks from the study area with those belonging to the Ordovician Famatinian suit exposed in the Sierra Grande de San Luis, suggest a genetic and temporal relation linked to the development of the Famatinian magmatic arc.
Ampliación de la distribución de Teius oculatus y T. suquiensis (Sauria: Teiidae en la provincia de San Luis (República Argentina
Directory of Open Access Journals (Sweden)
Guerreiro, Analía C.
Full Text Available Teius oculatus (D'Orbigny & Bibron, 1837. Dpto. La Capital. Localidades: Daniel Donovan (33°21'S; 66°15'W UNSUCH 0098; Ciudad de San Luis (33°18'S; 66°22'W UNSL-CH 0132, 0137. Teius suquiensis Avila & Martori, 1991. Dpto. La Capital. Localidades: Daniel Dono- van, UNSL-CH 0095, 0097, 0230; Ciudad de San Luis, UNSL-CH 0118, 0120, 0141, 0172, 0214, 0221; Ruta Prov. 3 (33°15'S; 66°18'W, UNSL-CH 0231, 0232. Dpto. Cnel. Pringles: La Florida (33°08'S; 66°02'W UNSL-CH 0223. Colectores: Juan Cruz Baldoni, Ana María Brigada, Matías García, Analía C. Guerreiro y Flavio Martínez.
Directory of Open Access Journals (Sweden)
Geneviève Fabry
Full Text Available This paper aims to study the intertextual traces dell Song of Songs in the work of Luis de León, San Juan de la Cruz and Juan Gelman from a particular point of view: the resonance in the vernacular of small biblical book as founder dimension of an experience spiritual, emotional and literary time. Choosing our corpus may surprise but, for one, would like to emphasize the importance of two pivotal moments in the reception of the Song: the Spanish Renaissance, whose approach to the Bible is enriched by new currents philological and exegetical of which Luis de León is a sublime representative; the late twentieth century in which an insistent intertextuality observed with sanjuanista work in one direction often foreign to Christian spirituality, as in the case of the Argentine Juan Gelman.
Inventario de recursos turísticos como base para la planificación territorial en la zona altiplano de san Luis Potosi, México
Directory of Open Access Journals (Sweden)
Paloma Blanco López
Full Text Available Este artículo aborda el análisis del potencial turístico como condición para la planificación turística. Se explica el turismo como factor de desarrollo y a la planificación como instrumento de su gestión. Se utilizan los municipios con mayor potencial turístico en la Zona Altiplano de San Luis Potosí para exponer y ejemplificar los resultados del diagnóstico de la región. Después se evalúan los instrumentos vigentes de planificación turística vigentes en San Luis Potosí y se ofrece una propuesta de aprovechamiento turístico con ayuda de un análisis FODA para los municipios seleccionados.
Testing jumps via false discovery rate control.
Yen, Yu-Min
Many recently developed nonparametric jump tests can be viewed as multiple hypothesis testing problems. For such multiple hypothesis tests, it is well known that controlling type I error often makes a large proportion of erroneous rejections, and such situation becomes even worse when the jump occurrence is a rare event. To obtain more reliable results, we aim to control the false discovery rate (FDR), an efficient compound error measure for erroneous rejections in multiple testing problems. We perform the test via the Barndorff-Nielsen and Shephard (BNS) test statistic, and control the FDR with the Benjamini and Hochberg (BH) procedure. We provide asymptotic results for the FDR control. From simulations, we examine relevant theoretical results and demonstrate the advantages of controlling the FDR. The hybrid approach is then applied to empirical analysis on two benchmark stock indices with high frequency data.
Testing jumps via false discovery rate control.
Directory of Open Access Journals (Sweden)
Yu-Min Yen
Full Text Available Many recently developed nonparametric jump tests can be viewed as multiple hypothesis testing problems. For such multiple hypothesis tests, it is well known that controlling type I error often makes a large proportion of erroneous rejections, and such situation becomes even worse when the jump occurrence is a rare event. To obtain more reliable results, we aim to control the false discovery rate (FDR, an efficient compound error measure for erroneous rejections in multiple testing problems. We perform the test via the Barndorff-Nielsen and Shephard (BNS test statistic, and control the FDR with the Benjamini and Hochberg (BH procedure. We provide asymptotic results for the FDR control. From simulations, we examine relevant theoretical results and demonstrate the advantages of controlling the FDR. The hybrid approach is then applied to empirical analysis on two benchmark stock indices with high frequency data.
El saxofón en la ópera de Luis de Pablo: La señorita Cristina
Directory of Open Access Journals (Sweden)
Martínez García, Francisco
Full Text Available At 82 years we will not mention the importance and influence of Luis de Pablo in the musical history of Spain in the last fifty years, but it was not what caught my attention for a PhD thesis on his music, but the the large number of works including saxophone in his catalog: 25 works upon today. It is a very high number compared to what Europeans frontline composers have produced during the twentieth century and the first decade of the 21st. From all this great production, surely excel his operas, as three of his five works dedicated to this genre, the saxophone is present and also with dramatic character roles. Then we will make an analysis of the opera La señorita Cristina, and the employment of the saxophone there, with musical contributions that eleven years after its release are certainly innovative and interesting.A sus 82 años no vamos a citar la importancia e influencia de Luis de Pablo en la historia musical de España en los últimos cincuenta años, pero no fue esto lo que me llamó la atención para realizar una tesis doctoral sobre su música1, sino la gran producción de obras con saxofón dentro de su catálogo: veinticinco obras al momento de hoy. Es un número muy alto comparándolo con lo que los compositores europeos de primera línea han llevado a cabo durante el siglo XX y primera década del XXI. De toda esta gran producción, destacan sin duda sus óperas, ya que en tres de sus cinco obras de este apartado, el saxofón está presente y además con funciones de personaje dramático. A continuación vamos a efectuar un análisis de la ópera La señorita Cristina y del empleo del saxofón en la misma, con unas aportaciones musicales que once años después de su estreno son sin duda novedosas y muy interesantes.
HPV genotype distribution and anomalous association of HPV33 to cervical neoplastic lesions in San Luis Potosí, Mexico.
DelaRosa-Martínez, Raúl; Sánchez-Garza, Mireya; López-Revilla, Rubén
The association of human papillomavirus (HPV) types to neoplastic lesions increase as a function of their oncogenicity and the duration of the infection since lesion severity progresses from low-grade to high-grade and cancer. In an outbreak, the prevalence of the HPV type involved would increase and the proportion of the associated low-grade lesions would predominate over severe lesions. In this study, the prevalence of HPV types and their association to neoplastic lesions was determined in women subjected to colposcopy in San Luis Potosí, Mexico. DNA from high-risk (HR) and low-risk (LR) HPV types was identified by E6 nested multiplex PCR in cervical scrapes from 700 women with normal cytology, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL) or invasive cervical cancer (CC). Overall HPV-DNA prevalence was 67.7 %, that of HR-HPV was 63.1 %, and that of LR-HPV was 21.3 %. The highest prevalence (78.2 %) occurred in the 15-24 year group, whereas that of single infections was 52 % and that of multiple infections (i.e., by 2-6 HPV types) was 48 %. The most prevalent HR types were HPV33 (33.1 %), HPV16 (16.6 %), HPV18 and HPV51 (6.7 % each). HR-HPV prevalence was 29.6 % in normal cytology, 26.7 % in ASCUS, 63.3 % in LSIL, 68.2 % in HSIL, and 90.5 % in CC. Three prevalence trends for HR-HPV types were found in neoplastic lesions of increasing severity: increasing (LSIL CC) for HPV33. Two-thirds of the women subjected to colposcopy from 2007 to 2010 in San Luis Potosí have HPV infections which predominate in the 15-24 years group. Around half of the infections are by one viral type and the rest by 2-6 types. HPV33 is the most prevalent type, followed by HPV16. Overall HR-HPV prevalence increases with the severity of neoplastic lesions. HPV33 prevalence is highest in LSIL and its U-shaped trend with progressing neoplastic lesions
Prediction and discovery of extremely strong hydrodynamic instabilities due to a velocity jump: theory and experiments
International Nuclear Information System (INIS)
Fridman, A M
The theory and the experimental discovery of extremely strong hydrodynamic instabilities are described, viz. the Kelvin-Helmholtz, centrifugal, and superreflection instabilities. The discovery of the last two instabilities was predicted and the Kelvin-Helmholtz instability in real systems was revised by us. (reviews of topical problems)
Engaging Students in Designing Movement: The Divergent Discovery Style of Teaching
Chatoupis, Constantine
In the divergent discovery style of teaching the teacher designs problems that engage students in finding multiple solutions. The purpose of this article is to show how physical educators can use the divergent discovery style in the gymnasium. A brief description of this style and its connection to the SHAPE America National Standards for K-12…
Association between Urine Fluoride and Dental Fluorosis as a Toxicity Factor in a Rural Community in the State of San Luis Potosi
Jarquín-Yañez, Lizet; Mejía-Saavedra, José de Jesús; Molina-Frechero, Nelly; Gaona, Enrique; Rocha-Amador, Diana Olivia; López-Guzmán, Olga Dania; Bologna-Molina, Ronell
Objective. The aim of this study is to investigate urine fluoride concentration as a toxicity factor in a rural community in the state of San Luis Potosi, Mexico. Materials and Methods. A sample of 111 children exposed to high concentrations of fluoride in drinking water (4.13?mg/L) was evaluated. Fluoride exposure was determined by measuring urine fluoride concentration using the potentiometric method with an ion selective electrode. The diagnosis of dental fluorosis was performed by clinica...
The incidence of essential competences and the owner-director on strong growth of a manufacturing SMEs in San Luis Potosí, Mexico
Molina Sánchez, Rubén
This article is intended to analyse a group of manufacturing SMEs in San Luis Potosí, Mexico, in order to explain the characteristics which bring about their high level of growth. The context was therefore adapted to a research model sponsored by OECD, which gives pride of place to qualitative methods, well-founded theory and the use of software to analyse information given by interviewees. Categories of perception of innovation were identified (that is, control of information, essential comp...
Neogene Tiporco Volcanic Complex, San Luis, Argentina: An explosive event in a regional transpressive - local transtensive setting in the pampean flat slab
Ibañes, Oscar Damián; Sruoga, Patricia; Japas, María Silvia; Urbina, y. Nilda Esther
The Neogene Tiporco Volcanic Complex (TVC) is located in the Sierras Pampeanas of San Luis, Argentina, at the southeast of the Pampean flat-slab segment. Based on the comprehensive study of lithofacies and structures, the reconstruction of the volcanic architecture has been carried out. The TVC has been modeled in three subsequent stages: 1) initial updoming, 2) ignimbritic eruptive activity and 3) lava dome emplacement. Interplay of magma injection and transtensional tectonic deformation has been invoked to reproduce TVC evolution.
Potential human health risk by 234,238U and 210Po due to consumption of fish from the "Luis L. Leon" reservoir (Northern Mexico)
Luna-Porres, M. Y.; Rodríguez-Villa, M. A.; Herrera-Peraza, E.; Cabral-Lares, M.; Renteria-Villalobos, M.; Montero-Cabrera, M. E.
The Conchos River is one of the most important in northern Mexico and the main surface waterway in the arid state of Chihuahua. The Luis L. Leon dam produces the Luis L. Leon Reservoir, which is the last major reservoir before the Conchos River enters the Rio Grande at the Texas-Chihuahua border. Activity concentrations (AC) of 234,238U and 210Po in fillet and liver of three stocked fish species (Lepomis cyanellus, Cyprinus carpio and Ictalurus furcatus), as well as in water from the Luis L. Leon reservoir were determined. 238U and 234U ACs in fillet samples showed values of 0.007-0.014 and 0.01-0.02 Bq kg-1 wet weight (ww), respectively. Liver samples for Lepomis cyanellus, Cyprinus carpio and Ictalurus furcatus species, present 210Po AC of 1.16-3.26 0.70-1.13 and 0.93-1.37 Bqṡkg-1 ww. The elemental Bioaccumulation Factor (BAF) for fish tissues respect to their concentrations in water was determined. Lepomis cyanellus species showed the highest BAF for total uranium in fillet, with value 1.5. The annual effective dose for uranium in adults by fish consumption in this work ranged from 4.46×10-3 to 3.68×10-2 μSvṡyear-1. The difference in concentrations of uranium in fillet among the studied species is likely primarily due to their differences in diet and habitat.
The tectonic significance of K/Ar illite fine-fraction ages from the San Luis Formation (Eastern Sierras Pampeanas, Argentina)
Wemmer, Klaus; Steenken, André; Müller, Stefan; de Luchi, Mónica G. López; Siegesmund, Siegfried
The Sierra de San Luis forms the southern tip of the Eastern Sierras Pampeanas in central Argentina. Two narrow belts of low-grade phyllites and quartz arenites, i.e. the San Luis Formation, have accommodated part of the strain-related differential exhumation of the medium- to high-grade metamorphic domains that constitute to the basement complex of the sierra. Eleven phyllite samples were subjected to the K/Ar fine-fraction dating technique. Results are interpreted in relation to the Kübler index of the illites, which indicate epimetamorphic conditions for the majority of the samples. Obtained ages between 330 and 290 Ma cover a period of compressional tectonics in the late Mississippian (Visean/Serpukhovian boundary) followed by the subsidence during the formation of the Paganzo Basin in the provinces of La Rioja and San Luis. These tectonic movements are coincident with the Toco orogeny in northern Chile and southern Bolivia. This suggests that the older K/Ar ages document the compressional stage and that younger ages record the cooling of the basement during the subsequent extensional uplift of the basement.
... 42 Public Health 3 2010-10-01 2010-10-01 false Discovery. 426.432 Section 426.432 Public Health... § 426.432 Discovery. (a) General rule. If the ALJ orders discovery, the ALJ must establish a reasonable timeframe for discovery. (b) Protective order—(1) Request for a protective order. Any party receiving a...
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Discovery. 27.21 Section 27.21... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for..., discovery is available only as ordered by the presiding officer. The presiding officer shall regulate the...
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery...
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 41.150 Section 41... COMMERCE PRACTICE BEFORE THE BOARD OF PATENT APPEALS AND INTERFERENCES Contested Cases § 41.150 Discovery. (a) Limited discovery. A party is not entitled to discovery except as authorized in this subpart. The...
... 19 Customs Duties 3 2010-04-01 2010-04-01 false Discovery. 354.10 Section 354.10 Customs Duties... ANTIDUMPING OR COUNTERVAILING DUTY ADMINISTRATIVE PROTECTIVE ORDER § 354.10 Discovery. (a) Voluntary discovery. All parties are encouraged to engage in voluntary discovery procedures regarding any matter, not...
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Discovery. 13.220 Section 13.220... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.220 Discovery. (a) Initiation of discovery. Any party may initiate discovery described in this section, without the consent or...
... 49 Transportation 7 2010-10-01 2010-10-01 false Discovery. 604.38 Section 604.38 Transportation... TRANSPORTATION CHARTER SERVICE Hearings. § 604.38 Discovery. (a) Permissible forms of discovery shall be within the discretion of the PO. (b) The PO shall limit the frequency and extent of discovery permitted by...
... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 719.10 Section 719.10... Discovery. (a) General. The parties are encouraged to engage in voluntary discovery regarding any matter... the Federal Rules of Civil Procedure relating to discovery apply to the extent consistent with this...
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Discovery. 16.213 Section 16.213... PRACTICE FOR FEDERALLY-ASSISTED AIRPORT ENFORCEMENT PROCEEDINGS Hearings § 16.213 Discovery. (a) Discovery... discovery permitted by this section if a party shows that— (1) The information requested is cumulative or...
... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Discovery. 76.21 Section 76.21 Judicial... POSSESSION OF CERTAIN CONTROLLED SUBSTANCES § 76.21 Discovery. (a) Scope. Discovery under this part covers... as a general guide for discovery practices in proceedings before the Judge. However, unless otherwise...
... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Discovery. 1150.63 Section... PRACTICE AND PROCEDURES FOR COMPLIANCE HEARINGS Prehearing Conferences and Discovery § 1150.63 Discovery. (a) Parties are encouraged to engage in voluntary discovery procedures. For good cause shown under...
... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...
... 49 Transportation 8 2010-10-01 2010-10-01 false Discovery. 1121.2 Section 1121.2 Transportation... TRANSPORTATION RULES OF PRACTICE RAIL EXEMPTION PROCEDURES § 1121.2 Discovery. Discovery shall follow the procedures set forth at 49 CFR part 1114, subpart B. Discovery may begin upon the filing of the petition for...
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.18 Section 26.18... PROCEDURES Hearings Before Hearing Officers Discovery § 26.18 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time after an answer has...
... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Discovery. 42.21 Section... IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.21 Discovery. (a) The following types of discovery are... creation of a document. (c) Unless mutually agreed to by the parties, discovery is available only as...
... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Discovery. 521.21 Section 521.21 Foreign... Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for... interpreted to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery is...
... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 10.71 Section 10.71 Money... SERVICE Rules Applicable to Disciplinary Proceedings § 10.71 Discovery. (a) In general. Discovery may be... relevance, materiality and reasonableness of the requested discovery and subject to the requirements of § 10...
... 42 Public Health 3 2010-10-01 2010-10-01 false Discovery. 426.532 Section 426.532 Public Health... § 426.532 Discovery. (a) General rule. If the Board orders discovery, the Board must establish a reasonable timeframe for discovery. (b) Protective order—(1) Request for a protective order. Any party...
... 39 Postal Service 1 2010-07-01 2010-07-01 false Discovery. 955.15 Section 955.15 Postal Service... APPEALS § 955.15 Discovery. (a) The parties are encouraged to engage in voluntary discovery procedures. In connection with any deposition or other discovery procedure, the Board may issue any order which justice...
... 49 Transportation 9 2010-10-01 2010-10-01 false Discovery. 1503.633 Section 1503.633... Rules of Practice in TSA Civil Penalty Actions § 1503.633 Discovery. (a) Initiation of discovery. Any party may initiate discovery described in this section, without the consent or approval of the ALJ, at...
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery. 35.21 Section 35.21 Public... AND STATEMENTS § 35.21 Discovery. (a) The following types of discovery are authorized: (1) Requests...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...
... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Discovery. 1264.120 Section 1264.120... PENALTIES ACT OF 1986 § 1264.120 Discovery. (a) The following types of discovery are authorized: (1..., discovery is available only as ordered by the presiding officer. The presiding officer shall regulate the...
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 128.6 Section 128.6 Foreign... Discovery. (a) Discovery by the respondent. The respondent, through the Administrative Law Judge, may... discovery if the interests of national security or foreign policy so require, or if necessary to comply with...
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 11.52 Section 11... Disciplinary Proceedings; Jurisdiction, Sanctions, Investigations, and Proceedings § 11.52 Discovery. Discovery... establishes that discovery is reasonable and relevant, the hearing officer, under such conditions as he or she...
... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discovery. 26.42 Section 26.42... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.42 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery procedures, which may commence at any time...
... 49 Transportation 5 2010-10-01 2010-10-01 false Discovery. 386.37 Section 386.37 Transportation... and Hearings § 386.37 Discovery. (a) Parties may obtain discovery by one or more of the following...; and requests for admission. (b) Discovery may not commence until the matter is pending before the...
... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 1955.32 Section 1955.32 Labor Regulations...) PROCEDURES FOR WITHDRAWAL OF APPROVAL OF STATE PLANS Preliminary Conference and Discovery § 1955.32 Discovery... allow discovery by any other appropriate procedure, such as by interrogatories upon a party or request...
... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Discovery. 16.21 Section 16.21 Money... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.21 Discovery. (a) The following types of discovery are authorized... to require the creation of a document. (c) Unless mutually agreed to by the parties, discovery is...
... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 766.9 Section 766.9... PROCEEDINGS § 766.9 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery... provisions of the Federal Rules of Civil Procedure relating to discovery apply to the extent consistent with...
43 CFR 4.1130 - Discovery methods.
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Discovery methods. 4.1130 Section 4.1130... Special Rules Applicable to Surface Coal Mining Hearings and Appeals Discovery § 4.1130 Discovery methods. Parties may obtain discovery by one or more of the following methods— (a) Depositions upon oral...
Residential and commercial space heating and cooling with possible greenhouse operation; Baca Grande development, San Luis Valley, Colorado. Final report
Energy Technology Data Exchange (ETDEWEB)
Goering, S.W.; Garing, K.L.; Coury, G.E.; Fritzler, E.A.
A feasibility study was performed to evaluate the potential of multipurpose applications of moderate-temperature geothermal waters in the vicinity of the Baca Grande community development in the San Luis Valley, Colorado. The project resource assessment, based on a thorough review of existing data, indicates that a substantial resource likely exists in the Baca Grande region capable of supporting residential and light industrial activity. Engineering designs were developed for geothermal district heating systems for space heating and domestic hot water heating for residences, including a mobile home park, an existing motel, a greenhouse complex, and other small commercial uses such as aquaculture. In addition, a thorough institutional analysis of the study area was performed to highlight factors which might pose barriers to the ultimate commercial development of the resource. Finally, an environmental evaluation of the possible impacts of the proposed action was also performed. The feasibility evaluation indicates the economics of the residential areas are dependent on the continued rate of housing construction. If essentially complete development could occur over a 30-year period, the economics are favorable as compared to existing alternatives. For the commercial area, the economics are good as compared to existing conventional energy sources. This is especially true as related to proposed greenhouse operations. The institutional and environmental analyses indicates that no significant barriers to development are apparent.
Blood lead concentrations in wild birds from a polluted mining region at Villa de La Paz, San Luis Potosi, Mexico.
Chapa-Vargas, Leonardo; Mejia-Saavedra, Jose J; Monzalvo-Santos, Karina; Puebla-Olivares, Fernando
This investigation was undertaken to determine the concentrations of lead in bird blood samples from a mining region in central Mexico and to compare concentrations among several different feeding guilds. The study took place in the Mexican state of San Luis Potosi in a region known as "Villa de la Paz." This is one of the most intensely exploited mining regions in central Mexico and has been actively mined for over four centuries. Lead concentrations from bird blood samples taken from four polluted sites were significantly higher than those from a control, unpolluted site (F = 6.3, P birds from a highly polluted site were higher than those from a site that has intermediate pollution levels (P birds had significantly lower lead concentrations compared to granivores, frugivores-insectivores, and omnivores (F = 4.86, P = 0.004), and a large proportion of all individuals had blood lead concentrations indicative of low, sub-lethal toxic effects. Finally, in two polluted sites, remarkably small numbers of insectivore-frugivores, and granivores were trapped, and in one polluted site a large number of insectivores was trapped (X(2) = 29.9, P = 0.03), and no differences in proportions of migrants and non-migrants were found among sampling sites (X(2) = 0.6, P = 0.96). To date, it has not been determined to what extent constant exposure to these levels of pollution can influence health at the individual level, lifespan, and, therefore, population demography of birds from this region.
Los rasgos de la lírica del exilio en la poética de Luis Cernuda
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Ana Martínez García
Full Text Available La obra literaria creada en el destierro por los españoles tuvo ciertos caracteres esenciales que le llevan a formar parte de una tendencia distinta, a no ligarse a los movimientos literarios coetáneos que se manifestaban en la península. La lírica fue el género más influenciado por la situación que los exiliados estaban experimentando, razón por la que sus textos pueden dividirse en periodos, con diferentes rasgos, dependientes de la situación histórica que experimentaban: Segunda Guerra Mundial, final de la guerra y afianzamiento del Franquismo, etc. Entre los muchos autores exiliados, Luis Cernuda fue uno de los más reconocidos, donde los rasgos de la poética del destierro estaban presentes, de una forma velada, trágica y sucinta, como era propio de toda su producción.
Detection of residual organochlorine and organophosphorus pesticides in agricultural soil in Rio Verde region of San Luis Potosi, Mexico.
Velasco, Antonio; Hernández, Sergio; Ramírez, Martha; Ortíz, Irmene
Organochlorine pesticides were intensively used in Mexico from 1950 until their ban and restriction in 1991. However, the presence of these compounds is commonly reported in many regions of the country. The aim of the present study was to identify and quantify residual organochlorine and organophosphorus pesticides in agricultural soil in Rio Verde region, San Luis Potosi state, which has been identified as possibly polluted by pesticides. Composed samples from 24 zones covering an area of approximately 5,440 ha were analyzed. The most frequently found pesticides were p,p'-DDT followed by ,p,p'-DDE, heptachlor, endosulfan and γ-HCH whose frequency rates were 100, 91, 83 and 54%, respectively. The concentration of p,p'-DDT in the crops grown in these soils was in the following order: chili > maize > tomato > alfalfa. The results obtained in this study show that p,p'-DDT values are lower or similar to those found in other agricultural regions of Mexico. Methyl and ethyl parathion were the most frequent organophosphate pesticide detected in 100% and 62.5% of the samples with average concentrations of 25.20 and 47.48 μg kg(-1), respectively. More research is needed to establish the background levels of pesticides in agricultural soils and their potential ecological and human health effects in this region.
Geochemistry of uranium in ground waters of the Conlara river Valley, San Luis and Cordoba provinces (Argentina)
International Nuclear Information System (INIS)
Nicolli, H.B.; Gamba, M.A.
Geochemical characteristics of ground waters related with lixiviation, transport and precipitation of uranium in the Conlara river valley (provinces of San Luis and Cordoba (Argentina)) are studied. Anions and cations' distributions, together with hardness, specific conductivity, pH, Eh, and uranium and vanadium contents, have been studied. Those parameters characterize four hidrogeochemical facies along an E-W profile: a calcic strong bicarbonate facies, an alkaline-calcic bicarbonate facies, an alkaline sulfate facies, and a strong alkaline sulfate facies. An ''Interphase zone'' (transition from bicarbonate water to sulfate water), where changes in composition may define a geochemical environment capable of UO2 precipitation, has been determined. The chemical-Thermodynamic studies give a dominance of UDC and UTC complexs ions (even in sulfate waters), so they represent the 99% of present ions. Besides, the calculated values required for equilibrium with uraninite or carnotite resulted much greater than those obtained in the performed experiments. It means that the precipitation of those minerals requires either the presence of greate amounts of uranium or vanadium, or a reducing environment with Eh values smaller than the observed ones. Finally, the steps to be taken in future investigations are suggested in view to a drilling plan where: 1) Priority to the ''Interphase zone'' areas is given. 2) The deepest aquifers in Tertiary sediments of the basin have to be reached in order to get the convenient environmental conditions (i.e. smallest Eh values) for uranium or uranium-vanadium precipitation. (author) [es
José Rosa y La guaracha del Macho Camacho de Luis Rafael Sánchez: texto, iconotexto y palimpsesto
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Rita De Maeseneer
Full Text Available La edición de Cátedra de La guaracha del Macho Camacho (2000 de Luis R. Sánchez lleva en su portada una reproducción incompleta de un llamativo cartel del artista puertorriqueño José Rosa. Esta obra, un iconotexto que estudiamos y reproducimos íntegramente, incorpora una rica serie de citas –falsas y verdaderas– de La guaracha. Proponemos un recorrido interpretativo de la configuración visual y textual de esta imagen, creada con otro fin que el de servir de pórtico a la novela. Con ella Rosa condensaba ya en 1977 de manera sorprendente muchos de los enfoques que los críticos literarios de Sánchez sólo desarrollarían mucho más tarde: la desacralización, el enmascaramiento racial, sexual y social, la dictadura del ocio y del consumo, el barroquismo... Como copista infiel y retozón, Rosa reinterpreta La guaracha insertando su autobiografía en ella y sobre todo insistiendo en que oigamos su trasfondo sonoro más profundo hecho de violencia, de racismo, de explotación y de exclusión.
Un empresario agrícola porfirista en Morelos. El caso de Luis García Pimentel
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María Carolina Moguel Pasquel
Full Text Available El objetivo del artículo es presentar la vida y trayectoria del empresario agrícola Luis García Pimentel, reconocido representante de la elite regional porfiriana de Morelos, propietario de dos haciendas azucareras ubicadas al oriente de la entidad, la de Santa Ana Tenango y la de Santa Clara Montefalco. El personaje se estudió desde el ámbito de la historia económica, mediante una escrupulosa investigación en siete archivos, y en bibliografía concerniente y actualizada del tema. Cabe destacar que no existen estudios similares de empresarios porfiristas de Morelos y la importancia de documentos encontrados en el Archivo de Notarias de la Ciudad de México que aportan información relevante y desconocida en fuentes secundarias. La monografía muestra cómo antes de la revolución, García Pimentel se desempeñaba exitosamente en los negocios, conocía su entorno y lo aprovechaba para aumentar sus ganancias. Tras la lucha armada, sin embargo, no pudo recuperar el auge económico anterior.
Frugivorous butterflies (Lepidoptera: Nymphalidae in Irmao Teodoro Luis Botanical Garden, Capao do Leao, Rio Grande do Sul, Brazil
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Janaína Madruga Silva
Full Text Available In Rio Grande do Sul, there's a lack of systematic information on frugivorous butterflies. This paper aimed survey the guild at Irmao Teodoro Luis Botanical Garden, an environment characterized by ecological tension between the semideciduous seasonal forest and the pioneer formations. The collections were made in three areas, each one containing five modified Van Someren-Rydon traps, baited with fermented banana. The traps remained on the field for six consecutive days per month, from September 2010 to August 2011. Within 10.800 hours of sampling effort, 453 individuals were recorded, distributed into 16 species, 15 genera, and 3 Nymphalidae subfamilies. Satyrinae was the richest and most abundant one, and two species from this group are very frequent and dominant. Richness rates indicated between 78% and 93% of the reported fauna, the species accumulation curve matches these values, and the diversity was 2.02 (H'. Prepona pylene Hewitson, [1854] and Archaeoprepona demophoon (Hübner, [1814] constitute new records for the Southern Coast of the state.
Community Response to Concentrating Solar Power in the San Luis Valley: October 9, 2008 - March 31, 2010
Energy Technology Data Exchange (ETDEWEB)
Farhar, B. C.; Hunter, L. M.; Kirkland, T. M.; Tierney, K. J.
This report is about the social acceptance of utility-scale concentrating solar power (CSP) plants in the San Luis Valley, approximately 200 miles southwest of Denver, Colorado. The research focused on social factors that may facilitate and impede the adoption and implementation of CSP. During the winter of 2008-2009, interviews were conducted with a purposive sample of 25 CSP-related stakeholders inside and outside the Valley. Interviews focused on the perceived advantages and disadvantages of siting a hypothetical 100-MW CSP facility in the Valley, the level of community support and opposition to CSP development, and related issues, such as transmission. State policy recommendations based on the findings include developing education programs for Valley residents, integrating Valley decision makers into an energy-water-land group, providing training for Valley decision makers, offering workforce training, evaluating models of taxation, and forming landholder energy associations. In addition, the SLV could become a laboratory for new approaches to CSP facility and transmission siting decision-making. The author recommends that outside stakeholders address community concerns and engage Valley residents in CSP decisions. Engaging the residents in CSP and transmission decisions, the author says, should take parallel significance with the investment in solar technology.
Concentrations of Environmental Chemicals in Urine and Blood Samples of Children from San Luis Potosí, Mexico.
Perez-Maldonado, Ivan N; Ochoa-Martinez, Angeles C; Orta-Garcia, Sandra T; Ruiz-Vera, Tania; Varela-Silva, Jose A
Human biomonitoring (HBM) is an appreciated tool used to evaluate human exposure to environmental, occupational or lifestyle chemicals. Therefore, the aim of this study was to evaluate the exposure levels for environmental chemicals in urine and blood samples of children from San Luis Potosí, Mexico (SLP). This study identifies environmental chemicals of concern such as: arsenic (45.0 ± 15.0 µg/g creatinine), lead (5.40 ± 2.80 µg/dL), t,t-muconic acid (266 ± 220 µg/g creatinine), 1-hydroxypyrene (0.25 ± 0.15 µmol/mol creatinine), PBDEs (28.0 ± 15.0 ng/g lipid), and PCBs (33.0 ± 16.0 ng/g lipid). On the other hand, low mercury (1.25 ± 1.00 µg/L), hippuric acid (0.38 ± 0.15 µg/g creatinine) and total DDT (130 ± 35 ng/g lipid) exposure levels were found. This preliminary study showed the tool's utility, as the general findings revealed chemicals of concern. Moreover, this screening exhibited the need for HBM in the general population of SLP.
Confined aquifer head measurements and storage properties in the San Luis Valley, Colorado, from spaceborne InSAR observations
Chen, Jingyi; Knight, Rosemary; Zebker, Howard A.; Schreüder, Willem A.
Interferometric Synthetic Aperture Radar (InSAR), a remote sensing technique for measuring centimeter-level surface deformation, is used to estimate hydraulic head in the confined aquifer of the San Luis Valley (SLV), Colorado. Reconstructing head measurements from InSAR in agricultural regions can be difficult, as InSAR phase data are often decorrelated due to vegetation growth. Analysis of 17 L-band ALOS PALSAR scenes, acquired between January 2007 and March 2011, demonstrates that comprehensive InSAR deformation measurements can be recovered over the vegetated groundwater basin with an improved processing strategy. Local skeletal storage coefficients and time delays between the head change and deformation are estimated through a joint InSAR-well data analysis. InSAR subsidence estimates are transformed to head changes with finer temporal and spatial resolution than is possible using existing well records alone. Both InSAR and well data suggest that little long-term water-storage loss occurred in the SLV over the study period and that inelastic compaction was negligible. The seasonal head variations derived from InSAR are consistent with the existing well data at most locations where confined aquifer pumping activity dominates. Our results demonstrate the advantages of InSAR measurements for basin-wide characterization of aquifer storage properties and groundwater levels over agricultural regions.
Luminescence dating of anthropogenic features of the San Luis Valley, Colorado: from stone huts to stone walls
Mahan, Shannon; Donlan, Rebecca A.; Kardos, Barbara Maat
The Snake Nest Wall site and the Crestone Stone Huts are in the northern San Luis Valley, Colorado, and provide a unique opportunity to date high-altitude archeological sites of unknown age and origin using optically stimulated luminescence (OSL). We sampled sediment underlying foundation stones of these structures to establish a chronological framework for each site's construction. OSL dating of the quartz grains directly under the Snake Nest Wall suggest that the stones and, therefore, the structure was most recently emplaced between 1855 and 1890 A.D. Dating of the sediment beneath the Crestone Stone Huts suggests the construction time of these huts is between 1860 and 1890 A.D. Analysis of the equivalent dose (DE) dispersion of the OSL samples at Snake Nest Wall and the Crestone Huts shows that the majority of sediments were fully bleached prior to deposition and the low scatter suggests that short-term or shallow alluvial processes were the dominant transport for sediments. In both cases, the OSL ages show that the construction was during very recent historical times, although it is likely that the Snake Nest Wall was rebuilt in the late 19th century. Further study is warranted at the Snake Nest Wall since it shows signs of greater antiquity and a continued presence of human use. The Crestone Huts are shown to be a product of railroad building during the boomtown days of Lucky and Crestone.
The Europa Ocean Discovery mission
Energy Technology Data Exchange (ETDEWEB)
Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others
Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.
Integration of Problem-Based Learning and Web-Based Multimedia to Enhance Soil Management Course
Strivelli, R.; Krzic, M.; Crowley, C.; Dyanatkar, S.; Bomke, A.; Simard, S.; Grand, S.
In an attempt to address declining enrolment in soil science programs and the changing learning needs of 21st century students, several universities in North America and around the world have re-organized their soil science curriculum and adopted innovative educational approaches and web-based teaching resources. At the University of British Columbia, Canada, an interdisciplinary team set out to integrate teaching approaches to address this trend. The objective of this project was to develop an interactive web-based teaching resource, which combined a face-to-face problem-based learning (PBL) case study with multimedia to illustrate the impacts of three land-uses on soil transformation and quality. The Land Use Impacts (LUI) tool (http://soilweb.landfood.ubc.ca/luitool/) was a collaborative and concentrated effort to maximize the advantages of two educational approaches: (1) the web's interactivity, flexibility, adaptability and accessibility, and (2) PBL's ability to foster an authentic learning environment, encourage group work and promote the application of core concepts. The design of the LUI case study was guided by Herrington's development principles for web-based authentic learning. The LUI tool presented students with rich multimedia (streaming videos, text, data, photographs, maps, and weblinks) and real world tasks (site assessment and soil analysis) to encourage students to utilize knowledge of soil science in collaborative problem-solving. Preliminary student feedback indicated that the LUI tool effectively conveyed case study objectives and was appealing to students. The resource is intended primarily for students enrolled in an upper level undergraduate/graduate university course titled Sustainable Soil Management but it is flexible enough to be adapted to other natural resource courses. Project planning and an interactive overview of the tool will be given during the presentation.
Deep Learning in Drug Discovery.
Gawehn, Erik; Hiss, Jan A; Schneider, Gisbert
Artificial neural networks had their first heyday in molecular informatics and drug discovery approximately two decades ago. Currently, we are witnessing renewed interest in adapting advanced neural network architectures for pharmaceutical research by borrowing from the field of "deep learning". Compared with some of the other life sciences, their application in drug discovery is still limited. Here, we provide an overview of this emerging field of molecular informatics, present the basic concepts of prominent deep learning methods and offer motivation to explore these techniques for their usefulness in computer-assisted drug discovery and design. We specifically emphasize deep neural networks, restricted Boltzmann machine networks and convolutional networks. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Sharma, Vivek
The recent observation of the Higgs boson has been hailed as the scientific discovery of the century and led to the 2013 Nobel Prize in physics. This book describes the detailed science behind the decades-long search for this elusive particle at the Large Electron Positron Collider at CERN and at the Tevatron at Fermilab and its subsequent discovery and characterization at the Large Hadron Collider at CERN. Written by physicists who played leading roles in this epic search and discovery, this book is an authoritative and pedagogical exposition of the portrait of the Higgs boson that has emerged from a large number of experimental measurements. As the first of its kind, this book should be of interest to graduate students and researchers in particle physics.
Bioinformatics in translational drug discovery.
Wooller, Sarah K; Benstead-Hume, Graeme; Chen, Xiangrong; Ali, Yusuf; Pearl, Frances M G
Bioinformatics approaches are becoming ever more essential in translational drug discovery both in academia and within the pharmaceutical industry. Computational exploitation of the increasing volumes of data generated during all phases of drug discovery is enabling key challenges of the process to be addressed. Here, we highlight some of the areas in which bioinformatics resources and methods are being developed to support the drug discovery pipeline. These include the creation of large data warehouses, bioinformatics algorithms to analyse 'big data' that identify novel drug targets and/or biomarkers, programs to assess the tractability of targets, and prediction of repositioning opportunities that use licensed drugs to treat additional indications. © 2017 The Author(s).
The discovery of subatomic particles
International Nuclear Information System (INIS)
Weinberg, S.
This book developed from a course for students with no prior training in mathematics of physics to learn about the achievements of 20th century physics and classical physics. It covers the discovery of fundamental particles of ordinary atoms: the electron, the proton, and the neutron. The general outline is historical and it is for readers unfamiliar with classical physics who wish to understand the ideas and experiments that make up the history of 20th century physics. Contents include: A world of particles, the discovery of the electron, the atomic scale, the nucleus, more particles
Subjectivity Policies for Educational Equality Opportunities. A Conversation Between Juan Carlos Tedesco and Luis Porter
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Luis Porter Galetar
Full Text Available This article seeks to answer a basic question: Is it possible to include the excluded? We understand the excluded as new social sectors, which are different from those we describe as marginal or exploited. Rather, these sectors are formed by the large and growing groups of people that contemporary society seems able to ignore. The article starts by analyzing what this new social condition implies to decision makers, and raises new questions. Do we want to live in a society that excludes 25 or 30% of its more needy population? Are we capable of learning to live together, as Jacques Delors asks in his UNESCO report? The ethical dilemma implied by these questions leads to a reflection on the technical-political dimension of inequality in regards to education. Tedesco and Porter open a dialogue that departs from a macro vision (including the use of new technology and the opening of new fields in educational policies and goes into the micro dimension of specific contexts, from those where people have some educational autonomy and project capacity, to those where people find themselves in situations of anonymity and social dissolution. Learning to live together implies taking on responsibility for the other, and of knowing the other. In order to break with the social determinism that can lead to fatalist scenarios, it is important to understand that educational success or failure is a systemic phenomenon that depends on a multiple of variables. Governments have responded to the complexity of the problem with 'objective' measures that principally affect the material. In this article we support the idea that an attempt to bring about a greater recognition of the subjective dimension is missing in current educational policy. To achieve this we identify certain characteristics that various studies have shown as basic requirements to confront the problem: project capacity, narrative capacity and enhanced self-confidence.
Knowledge discovery with classification rules in a cardiovascular dataset.
Podgorelec, Vili; Kokol, Peter; Stiglic, Milojka Molan; Hericko, Marjan; Rozman, Ivan
In this paper we study an evolutionary machine learning approach to data mining and knowledge discovery based on the induction of classification rules. A method for automatic rules induction called AREX using evolutionary induction of decision trees and automatic programming is introduced. The proposed algorithm is applied to a cardiovascular dataset consisting of different groups of attributes which should possibly reveal the presence of some specific cardiovascular problems in young patients. A case study is presented that shows the use of AREX for the classification of patients and for discovering possible new medical knowledge from the dataset. The defined knowledge discovery loop comprises a medical expert's assessment of induced rules to drive the evolution of rule sets towards more appropriate solutions. The final result is the discovery of a possible new medical knowledge in the field of pediatric cardiology.
Pattern Discovery in Time-Ordered Data; TOPICAL
International Nuclear Information System (INIS)
This report describes the results of a Laboratory-Directed Research and Development project on techniques for pattern discovery in discrete event time series data. In this project, we explored two different aspects of the pattern matching/discovery problem. The first aspect studied was the use of Dynamic Time Warping for pattern matching in continuous data. In essence, DTW is a technique for aligning time series along the time axis to optimize the similarity measure. The second aspect studied was techniques for discovering patterns in discrete event data. We developed a pattern discovery tool based on adaptations of the A-priori and GSP (Generalized Sequential Pattern mining) algorithms. We then used the tool on three different application areas-unattended monitoring system data from a storage magazine, computer network intrusion detection, and analysis of robot training data
Quarks, history of a discovery
International Nuclear Information System (INIS)
Husson, D.
This book gives a presentation of quarks and stresses on the historical aspects of the studies that led to their discovery. The 'aesthetical' motivations of the scientists in their research are explained with only a minimum of mathematical concepts. (J.S.)
International Nuclear Information System (INIS)
Cherenkov, P.A.
The author, the discoverer of the Cherenkov radiation, recalls some interesting circumstances of his discoery 50 years ago and puts it into the context of the knowledge of the period. The discovery of Cherenkov radiation which today is in practice used especially for the detection of charged particles, was correctly understood and appreciated somewhat belatedly. At first the discovery was met with distrust and the original article announcing it was rejected by the magazine Nature. In effect, the discovery was not the result of any planned experiment but was the by-product of another research. It was, of course, allowed by previous achievements in various fields of physics, namely progress reached in the study of luminescence by S.I. Vavilov and his pupils. The discovery was made during an experimental study of luminescence induced in liquids by the β and γ radiations of uranyl salts. During his attempts to suppress the background radiation from vessel walls the autor found a ''background'' from pure solvent which differed from luminescence by being independent of the concentration, temperature and viscosity of the liquid. A closer examination of the phenomenon more or less by accident revealed its marked spatial asymmetry which had major importance for the development of the theory of the new phenomenon by I.V. Tamm and I.M. Frank. (A.K.)
Lindberg Christensen, Lars; Kornmesser, M
Hubble: 15 Years of Discovery was a key element of the European Space Agency's 15th anniversary celebration activities for the 1990 launch of the NASA/ESA Hubble Space Telescope. As an observatory in space, Hubble is one of the most successful scientific projects of all time, both in terms of scientific output and its immediate public appeal.
Applied metabolomics in drug discovery.
Cuperlovic-Culf, M; Culf, A S
The metabolic profile is a direct signature of phenotype and biochemical activity following any perturbation. Metabolites are small molecules present in a biological system including natural products as well as drugs and their metabolism by-products depending on the biological system studied. Metabolomics can provide activity information about possible novel drugs and drug scaffolds, indicate interesting targets for drug development and suggest binding partners of compounds. Furthermore, metabolomics can be used for the discovery of novel natural products and in drug development. Metabolomics can enhance the discovery and testing of new drugs and provide insight into the on- and off-target effects of drugs. This review focuses primarily on the application of metabolomics in the discovery of active drugs from natural products and the analysis of chemical libraries and the computational analysis of metabolic networks. Metabolomics methodology, both experimental and analytical is fast developing. At the same time, databases of compounds are ever growing with the inclusion of more molecular and spectral information. An increasing number of systems are being represented by very detailed metabolic network models. Combining these experimental and computational tools with high throughput drug testing and drug discovery techniques can provide new promising compounds and leads.
Nobel Prize Honors Autophagy Discovery.
Japanese cell biologist Yoshinori Ohsumi, PhD, was awarded this year's Nobel Prize in Physiology or Medicine for his discovery of autophagy. His groundbreaking studies in yeast cells illuminated how cells break down and recycle damaged material, a process that is critical to the survival of both normal cells and some cancer cells. ©2016 American Association for Cancer Research.
Translational medicine and drug discovery
National Research Council Canada - National Science Library
Littman, Bruce H; Krishna, Rajesh
..., and examples of their application to real-life drug discovery and development. The latest thinking is presented by researchers from many of the world's leading pharmaceutical companies, including Pfizer, Merck, Eli Lilly, Abbott, and Novartis, as well as from academic institutions and public- private partnerships that support translational research...
International Nuclear Information System (INIS)
Alazard-Toux, N.
During the period 1999-2003, new oil and gas fields generated additional reserves of nearly 11 000 bcm of natural gas and 62 Gbbl of oil and condensates, volumes very much superior to those discovered in the five previous years. Two-thirds of these discoveries were located offshore, half in deep water. (author)
Maximum Entropy in Drug Discovery
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Chih-Yuan Tseng
Full Text Available Drug discovery applies multidisciplinary approaches either experimentally, computationally or both ways to identify lead compounds to treat various diseases. While conventional approaches have yielded many US Food and Drug Administration (FDA-approved drugs, researchers continue investigating and designing better approaches to increase the success rate in the discovery process. In this article, we provide an overview of the current strategies and point out where and how the method of maximum entropy has been introduced in this area. The maximum entropy principle has its root in thermodynamics, yet since Jaynes' pioneering work in the 1950s, the maximum entropy principle has not only been used as a physics law, but also as a reasoning tool that allows us to process information in hand with the least bias. Its applicability in various disciplines has been abundantly demonstrated. We give several examples of applications of maximum entropy in different stages of drug discovery. Finally, we discuss a promising new direction in drug discovery that is likely to hinge on the ways of utilizing maximum entropy.
Structural Biology Guides Antibiotic Discovery
Polyak, Steven
Modern drug discovery programs require the contribution of researchers in a number of specialist areas. One of these areas is structural biology. Using X-ray crystallography, the molecular basis of how a drug binds to its biological target and exerts its mode of action can be defined. For example, a drug that binds into the active site of an…
Geología de la parte sur de la Sierra de San Luis y granitoides asociados, Argentina
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Llambías, E. J.
Full Text Available The lower Palaeozoic basement of the southern part of Sierra de San Luis, Argentina, is made up of metamorphic rocks, granitoids and ultramafic rocks. The metamorphic grade ranges from the lower limit of greenschist facies through the upper limit of amphibolite facies, in apparent transition. The lower grade metamorphic rocks include slates, metavolcanics, metaconglomerates, quartzites and phyllites. Rocks with intermediate metamorphism are biotite-quartz-oligoclase schists with abundant pegmatoid veins. The higher grade metamorphism is represented by gneisses, amphibolites and migmatites, to which mafic and ultramafic bodies are associated. Three deformation phases have been recognized, being the last one (D3, of ordovician age, responsible of the most marked structures.The granitoids were grouped into pre-, syn- and post-kynematic bodies respect to D3. The pre-kynematic granitoids are located within the belt of lower grade metamorphic rocks and are composed of tonalites, granodiorites and monzogranites, strongly deformed. Their age is unknown. The syn-kynematic bodies are mainly garnet-moscovite-bearing leucogranodiorites. They show low thermal and rheological contrasts respect to the country rocks, and the age is 454 ± 21 m.a. The post-kynematic granitoids are mainly monzogranites with K-feldspar megacrysts and abundant sphene. They are subcircular and discordant, and are associated with an extensional regime. Their age is comprised between 423 and 320 m.a., and corresponds to the end of the Famatinian cycle.El basamento cristalino de la parte sur de la Sierra de San Luis, de edad Paleozoico Inferior, está constituido por rocas metamórficas, granitoides y rocas ultramáficas. El grado de metamorfismo varía desde la parte baja de esquistos verdes hasta la parte alta de la facies anfibolita, siendo sus relaciones de aparente transicionalidad. Las rocas con menor grado metamórfico consisten en pizarras, metavolcanitas, metaconglomerados
A la costa de Luis A. Martínez: ¿la defensa de un proyecto liberal para Ecuador?
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Full Text Available A LA COSTA DE LUIS A. MARTINEZ : LA DEFENSE DUN PROJET LIBERAL POUR LÉQUATEUR ? A la Costa est souvent analysé comme une peinture de moeurs, témoignage de la réalité sociale et politique de l´Équateur de la fin du XIX et du début du XX. En effet, ce roman prétend décrire le conflit traditionnel qui oppose socialement, économiquement et politiquement les Andes et la Côte. Mais il se présente aussi et surtout comme la défense d´un projet libéral pour l´Équateur et développe une démonstration idéologique systématique. En outre, il propose une lecture du sens de la vie et une réflexion sur le devenir de l´homme dont la portée dépasse largement l´argumentation idéologique. Ce sont sans aucun doute ces nuances, introduites tout au long de la narration, qui permettent à l´oeuvre d´échapper à son statut exemplaire, simple témoignage d´une époque, pour proposer une vision personnelle et créative. Muchos han visto en A la Costa una novela de tendencia costumbrista, testimonio de la realidad social y política del Ecuador a finales del siglo XIX y comienzos del XX. En efecto, la novela pretende describir el conflicto tradicional social, económico, político entre Sierra y Costa. Pero es también, y ante todo, la defensa de un proyecto liberal para Ecuador, desarrollando una sistemática demostración ideológica. Además, propone una lectura del sentido de la vida y una reflexión sobre el porvenir del hombre cuyo alcance va más allá de la defensa de un proyecto ideológico. Sin duda son estos matices, introducidos a lo largo de la narración, los que permiten que la obra escape del estatuto de novela ejemplar y testimonial para proponer una visión autónoma y creativa. THE NOVEL A LA COSTA OF LUIS A. MARTÍNEZ: THE DEFENSE OF A LIBERAL PROJECT FOR ECUADOR? The novel A la Costa has often been analyzed as a portrait of national costumes, a testimony to the social and political realities of Ecuador at the end of
[Geographic distribution of birds in the Sierra Madre Oriental of San Luis Potosi, Mexico: a regional analysis of conservation status].
Sahagún Sánchez, Francisco Javier; Navarro, Jaime Castro; Reyes Hernández, Humberto
The Sierra Madre Oriental region in the mexican state of San Luis Potosi is a relevant place for bird conservation at a country level. Therefore the main goal of this study was to analyze the geographic patterns of distribution and the conservation current state of the birds, to support the needs to expand the conservation areas in the future. Data was collected from various databases of zoological museums and collections, and field sampling methods conducted from January 2009 to May 2011. Potential distributions were modeled for 284 species using GARP software and then a map was developed to determine areas with favorable environmental characteristics for the distribution of species richness. Finally, the importance of conservation areas for the potential distribution of birds in the region was evaluated. A total of 359 species were recorded of which 71.4% are permanent residents, 19% are winter migrants and 4% are summer residents. From this total, 41 species were endemic, 47 were species at risk and 149 were neotropical migrants. The largest species richness correspond to oak forests, cloud forests, and tropical moist forests located at altitudes from 100m to 1 500m. Their potential distribution was concentrated towards the center and Southeast of the study area. Only 10% of areas with a high potential conservation was included in areas of priority for bird conservation (AICA) and just 3% of all potential areas were under some governmental category of protection. However, no conservation area has a management plan currently applied and monitored. The information generated is important for the development of management proposals for birds conservation in the region.
Poate fi corectată atestarea lui copt, –ă (1887, DLR, pe baza CL 1699?
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Adina Chirilă
Full Text Available În 1699, traducînd din greacă un text al lui Maxim Peloponesianul, Antim Ivireanul utilizează un cuvînt ce, la prima vedere, coincide cu un neologism atestat în limba română abia în secolul al XIX-lea, ca împrumut din limba franceză: copt, –ă, 'Locuitor [...] al Egiptului, descinzînd din vechile secte creștine ale Euticheenilor'. Pentru a răspunde întrebării din titlu, a fost necesară analiza conținutului semantic al termenului corespunzător din textul-sursă grecesc, i.e. κόπται (și, implicit, etimologia acestuia, dat fiind faptul că, pentru perioada în care a scris Maxim Peloponesianul, lucrările lexicografice ce vizează limba greacă înregistrează clar doar forma cu îndelungată tradiție κóπτης (pl. κόπται – derivat al verbului κόπ(τω –της 'a tăia, a lovi', iar posibilitatea ca autorul grec de la începutul secolului al XVII-lea să fi avut în vedere acest înțeles nu putea fi eliminată ab initio. Demersul conduce spre un răspuns afirmativ și, în plus, ar putea arunca o nouă lumină asupra dinamicii lingvistice grecești în epoca post- bizantină.
Jorge Luis Borges and the New Physics: the Literature of Modern Science and the Science of Modern Literature
Mosher, Mark Robert
By examining the works of the Argentine writer, Jorge Luis Borges, and the parallels it has with modern physics, literature and science converge in their quest for truth regarding the structure and meaning of the universe. The classical perception of physics as a "hard" science--that of quantitative, rational thought which was established during the Newtonian era--has been replaced by the "new physics," which integrates the so-called "soft" elements into its paradigm. It presents us with a universe based not exclusively on a series of particle-like interactions, or a "billiard-ball" hypothesis where discrete objects have a measurable position and velocity in absolute space and time, but rather on a combination of these mechanistic properties and those that make up the non-physical side of nature such as intuition, consciousness, and emotion. According to physicists like James Jeans science has been "humanized" to the extent that the universe as a "great machine" has been converted into a "great thought.". In nearly all his collections of essays and short stories, Borges complements the new physics by producing a literature that can be described as "scientized." The abstract, metaphysical implications and concerns of the new world-view, such as space, time, language, consciousness, free will, determinism, etc., appear repeatedly throughout Borges' texts, and are treated in terms that are remarkably similar to those expressed in the scientific texts whose authors include Albert Einstein, Niels Bohr, Werner Heisenberg, and Erwin Schrodinger. As a final comparison, Borges and post-modern physicists address the question of the individual's ability to ever comprehend the universe. They share an attitude of incredulity toward all models and theories of reality simply because they are based on partial information, and therefore seen only as conjectures.
Algal and Cyanobacterial communities in two rivers of the province of San Luis (Argentina subjected to anthropogenic influence
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Jorgelina Daruich
Full Text Available AIM: The use of biological indicators of pollution has increased in recent years as an alternative to the monitoring of water quality. Phytoplankton community selectively respond to different anthropogenic disturbances, such as water dams and the increase of nutrients coming from city centers, which leads to the eutrophication of the aquatic environment. The objective of this work was to evaluate the composition and the structure of the algal and Cyanobacterial communities in order to prove human influences by the presence of reservoirs with some degree of eutrophication and the impact of urbanization in two rivers at the Bebedero basin in San Luis province (Argentine. METHODS: Four sites were sampled: two of them were placed before dams and villages (V1 and (P1 and two after them (V2 and (P2. Each site was visited in every season of the year: summer, autumn, winter and spring. Qualitative and semi-quantitative phytoplankton samples were taken, and the frequency of occurrence was determined. Variations between pairs of sampling stations were analyzed through the Jaccard similarity and complementarity indices. RESULTS: Ninety two taxa were identified, of which diatoms were the most frequent. The most affected station was P2 with high abundance, less diversity and equitability, whereas the species more tolerant to the presence of organic matter were Melosira varians, Navicula tripunctata, Oscillatoria limosa, Gomphonema parvulum and Coelastrum microporum, and some species of euglenophytas. CONCLUSION: Therefore, the structure and composition of the algal and Cyanobacterial communities allowed us to identify sections more sensitive to human-induced alterations.
Climate, streamflow, and legacy effects on growth of riparian Populus angustifolia in the arid San Luis Valley, Colorado
Andersen, Douglas
Knowledge of the factors affecting the vigor of desert riparian trees is important for their conservation and management. I used multiple regression to assess effects of streamflow and climate (12–14 years of data) or climate alone (up to 60 years of data) on radial growth of clonal narrowleaf cottonwood (Populus angustifolia), a foundation species in the arid, Closed Basin portion of the San Luis Valley, Colorado. I collected increment cores from trees (14–90 cm DBH) at four sites along each of Sand and Deadman creeks (total N = 85), including both perennial and ephemeral reaches. Analyses on trees conditions was common. Models for trees farther from the channel or over a deep water table explained 23–71% of SGI variability, and 4 of 5 contained a streamflow variable. Analyses using solely climate variables over longer time periods explained 17–85% of SGI variability, and 10 of 12 included a variable indexing summer precipitation. Three large, abrupt shifts in recent decades from wet to dry conditions (indexed by a seasonal Palmer Drought Severity Index) coincided with dramatically reduced radial growth. Each shift was presumably associated with branch dieback that produced a legacy effect apparent in many SGI series: uncharacteristically low SGI in the year following the shift. My results suggest trees in locations distant from the active channel rely on the regional shallow unconfined aquifer, summer rainfall, or both to meet water demands. The landscape-level differences in the water supplies sustaining these trees imply variable effects from shifts in winter-versus monsoon-related precipitation, and from climate change versus streamflow or groundwater management.
Assessment of groundwater contamination by gypsum dissolution in San Luis Potosí (México) using geoelectrical characterization
Arango-Galvan, C.; Ramos-Leal, J. A.; Yáñez-Rodríguez, M. A.; Corbo-Camargo, F.
The Cerritos and Río Verde aquifers in San Luis Potosí (central México) make up a very complex aquifer system that is seriously affected by the overexploitation and the high concentration of sulphates. Currently, it is partially closed for extraction causing a substantial decrease in per capita drinking water availability affecting to more than 50,000 inhabitants in the region. Therefore, a very comprehensive study has been proposed in order to evaluate not only the groundwater contamination distribution but also to better know the aquifer configuration and its main hydrogeological characteristics as well. These studies include a detailed geological reconnaissance, hydrogeochemical analyses and a geoelectrical characterization. The main goal is to assess the aquifer geometry and to identify the gypsum horizons causing the presence of higher concentrations of sulphates in drinking water. A total of 26 audiomagnetotelluric soundings were measured and modelled along profiles following a perpendicular direction to the NW regional trending. Two-dimensional resistivity models suggest the presence of a shallow conductive layer (C1) with resistivity values ranging from 10 to 20 Ohm.m. It is related to the upper aquifer with a very low exploitation potential. A less conductive horizon (C2; 50 Ohm.m) underlying the shallow aquifer could be related to a very fractured limestone horizon forming a confined aquifer in the middle of the valley. A very resistive layer (R1) is observed underlying C1 and C2 units. This strata shows higher resistivity values (>100 Ohm.m) and could be associated with a reefal limestone identified as El Abra Formation. Finally, a conductive layer (<100 Ohm.m) observed beneath this horizon could be related to the oldest stratigraphic unit outcropping on the region, the Guaxcamá Formation, a gypsum-enriched unit, that contributes to the presence of sulphates in the upper aquifers by dissolution processes.
DNA methylation changes in Mexican children exposed to arsenic from two historic mining areas in San Luis potosí.
Alegría-Torres, Jorge Alejandro; Carrizales-Yánez, Leticia; Díaz-Barriga, Fernando; Rosso-Camacho, Fernando; Motta, Valeria; Tarantini, Letizia; Bollati, Valentina
Arsenic is a carcinogen and epimutagen that threatens the health of exposed populations worldwide. In this study, we examined the methylation status of Alu and long interspersed nucleotide elements (LINE-1) and their association with levels of urinary arsenic in 84 Mexican children between 6 and 12 years old from two historic mining areas in the State of San Luis Potosí, Mexico. Urinary arsenic levels were determined by atomic absorption spectrophotometry and DNA methylation analysis was performed in peripheral blood leukocytes by bisulfite-pyrosequencing. The geometric mean of urinary arsenic was 26.44 µg/g Cr (range 1.93-139.35). No significant differences in urinary arsenic or methylation patterns due to gender were observed. A positive correlation was found between urinary arsenic and the mean percentage of methylated cytosines in Alu sequences (Spearman correlation coefficient r = 0.532, P < 0.001), and a trend of LINE-1 hypomethylation was also observed (Spearman correlation coefficient r = -0.232, P = 0.038) after adjustment for sex and age. A linear regression model showed an association with log-normalized urinary arsenic for Alu (β = 1.05, 95% CI: 0.67; 1.43, P < 0.001) and LINE-1 (β = -0.703, 95% CI: -1.36; -0.38, P = 0.038). Despite the low-level arsenic exposure, a subtle epigenetic imbalance measured as DNA methylation was detected in the leukocytes of Mexican children living in two historic mining areas. Environ. Mol. Mutagen. 57:717-723, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.
Review of samples of water, sediment, tailings, and biota at the Little Bonanza mercury mine, San Luis Obispo County, California
Rytuba, James J.; Hothem, Roger L.; Goldstein, Daniel N.; Brussee, Brianne E.; May, Jason T.
Background and Objectives The Little Bonanza mercury (Hg) mine, located in San Luis Obispo County, California, is a relatively small mine with, a historical total Hg production of about 1,000 flasks. The mine workings and tailings are located in the headwaters of the previously unnamed west fork of Las Tablas Creek (WF Las Tablas Creek), which flows into the Nacimiento Reservoir. Wasterock and tailings eroded from the Little Bonanza Hg Mine have contributed Hg-enriched mine wastes to the headwaters of WF Las Tablas Creek. The mine is located on Federal land managed by the U.S. Bureau of Land Management (BLM), which requested that the U.S. Geological Survey (USGS) measure and characterize Hg and other geochemical constituents in tailings, sediment, water, and biota at and downstream from the minesite. This report is in response that request, from the lead agency which is mandated to conduct a Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) - Removal Site Investigation (RSI). The RSI applies to removal of Hg-contaminated mine waste from the Little Bonanza minesite as a means of reducing Hg transport to WF Las Tablas Creek. This report summarizes data obtained from field sampling of mine tailings, wasterock, sediment, water, and biota at the Little Bonanza Mine that was completed on April 6, 2010. Conditions during sampling were dry and no rain had occurred in the watershed for several weeks. Our results permit a preliminary assessment of the mining sources of Hg and associated chemical constituents that could produce elevated levels of monomethyl mercury (MMeHg) in WF Las Tablas Creek and in biota.
Una Estrategia de Desarrollo Local: Comunidad de San Luis Sesma, México
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Diosey Lugo
Full Text Available El presente trabajo analiza la problemática que guarda San Luís Sesma, comunidad perteneciente al municipio de Mazapiltepec de Juárez, Puebla, desde una perspectiva de análisis que nos permita comprender la relación que guarda esta comunidad con su territorio y que se ha mantenido relativamente marginada, con una producción autárquica de los sistemas agropecuarios, además de una desarticulación institucional, el crecimiento de la migración hacia otras regiones como estrategia de subsistencia y de aumentar el ingreso familiar en la incorporación hacia otros sectores. Ante lo anterior, un grupo de estudiantes del Postgrado en Estrategias Agrícolas Regional del Colegio de Posgraduados, Campus Puebla, encuentran una oportunidad para proponer líneas de acción estratégicas de corto y mediano plazo en el sector agropecuario, en base a los recursos naturales disponibles de la comunidad, y el involucramiento de los actores sociales a través de la organización como elemento articulador del grupo de productores de San Luís Sesma y la participación de las instituciones gubernamentales mediante los programas estatales y federales que promuevan una transferencia de tecnología, de experiencias, de recursos, de tal manera que todo lo anterior coadyuve a aumentar los sistemas de producción y por ende se vea reflejado en mejores ingresos para los productores de la comunidad.
The discovery of drug-induced illness.
Jick, H
The increased use of drugs (and the concurrent increased risks of drug-induced illness) require definition of relevant research areas and strategy. For established marketed drugs, research needs depend on the magnitudes of risk of an illness from a drug and the base-line risk. With the drug risk high and the base-line risk low, the problem surfaces in premarketing studies or through the epidemic that develops after marketing. If the drug adds slightly to a high base-line risk, the effect is undetectable. When both risks are low, adverse effects can be discovered by chance, but systematic case-referent studies can speed discovery. If both risks are high, clinical trials and nonexperimental studies may be used. With both risks intermediate, systematic evaluations, especially case-referent studies are needed. Newly marketed drugs should be routinely evaluated through compulsory registration and follow-up study of the earliest users.
Data Warehouse Discovery Framework: The Foundation
Apanowicz, Cas
The cost of building an Enterprise Data Warehouse Environment runs usually in millions of dollars and takes years to complete. The cost, as big as it is, is not the primary problem for a given corporation. The risk that all money allocated for planning, design and implementation of the Data Warehouse and Business Intelligence Environment may not bring the result expected, fare out way the cost of entire effort [2,10]. The combination of the two above factors is the main reason that Data Warehouse/Business Intelligence is often single most expensive and most risky IT endeavor for companies [13]. That situation was the main author's inspiration behind founding of Infobright Corp and later on the concept of Data Warehouse Discovery Framework.
... often, it could be a sign of a balance problem. Balance problems can make you feel unsteady. You may ... related injuries, such as a hip fracture. Some balance problems are due to problems in the inner ...
Embarazo, parto y puerperio: creencias y prácticas de parteras en San Luis Potosí, México Gravidez, parto e puerpério: crenças e práticas de parteiras em San Luis Potosi, México Pregnancy, delivery and puerperium: beliefs and practices of midwives in San Luis Potosi, Mexico
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Blanca Pelcastre
Full Text Available OBJETIVO: Documentar las creencias y las prácticas de las parteras tradicionales respecto al embarazo parto y puerperio. MÉTODOS: Aprovechando un curso de capacitación de 160 parteras tradicionales locales de las regiones Media y Huasteca del Estado de San Luis Potosí, México, dos de las enfermeras-instructoras entrevistaron a 25 de los capacitandos, apoyadas por un miembro de las comunidades náhuatl y tenek. La identidad de los participantes se mantiene anónima y se obtuvo permiso para publicar los resultados mediante consentimiento informado. RESULTADOS: Las prácticas de las parteras (os tradicionales son comunes en los grupos sociales que carecen de servicios de salud. Sus funciones no están limitadas al parto e incluyen nutrición, cuidados prenatales, del puerperio y la lactancia, así como apoyo afectivo emocional de las madres parturientas y sus familiares. En este estudio se registraron varios mitos y terapias tradicionales. CONCLUSIÓN: Los recursos de la terapia tradicional y de la atención primaria de la salud de las parteras Náhuatl y Tenek son útiles y benéficos para los cuidados perinatales.OBJETIVO: Documentar as crenças e as práticas das parteiras tradicionais quanto à gravidez, parto e puerpério. MÉTODO: Aproveitando um curso de capacitação de 160 parteiras tradicionais locais das regiões Media e Huasteca do Estado de São Luís Potosi, México, duas das enfermeiras-instrutoras entrevistaram 25 participantes do curso, apoiadas por um membro das comunidades náhuatl e tenek. Foi garantido o anonimato dos participantes, que concordaram com a publicação dos resultados, mediante o termo de consentimento esclarecido. RESULTADOS: As práticas das (os parteiras (os tradicionais são comuns nos grupos sociais carentes de servicos de saúde. Suas funções não estão limitadas ao parto, compreendem nutrição, cuidados do pré-natal, do puerpério e da lactância, assim como apoio afetivo emocional das m
[Population problem, comprehension problem].
Tallon, F
Overpopulation of developing countries in general, and Rwanda in particular, is not just their problem but a problem for developed countries as well. Rapid population growth is a key factor in the increase of poverty in sub-Saharan Africa. Population growth outstrips food production. Africa receives more and more foreign food, economic, and family planning aid each year. The Government of Rwanda encourages reduced population growth. Some people criticize it, but this criticism results in mortality and suffering. One must combat this ignorance, but attitudes change slowly. Some of these same people find the government's acceptance of family planning an invasion of their privacy. Others complain that rich countries do not have campaigns to reduce births, so why should Rwanda do so? The rate of schooling does not increase in Africa, even though the number of children in school increases, because of rapid population growth. Education is key to improvements in Africa's socioeconomic growth. Thus, Africa, is underpopulated in terms of potentiality but overpopulated in terms of reality, current conditions, and possibilities of overexploitation. Africa needs to invest in human resources. Families need to save, and to so, they must refrain from having many children. Africa should resist the temptation to waste, as rich countries do, and denounce it. Africa needs to become more independent of these countries, but structural adjustment plans, growing debt, and rapid population growth limit national independence. Food aid is a means for developed countries to dominate developing countries. Modernization through foreign aid has had some positive effects on developing countries (e.g., improved hygiene, mortality reduction), but these also sparked rapid population growth. Rwandan society is no longer traditional, but it is also not yet modern. A change in mentality to fewer births, better quality of life for living infants, better education, and less burden for women must occur
Quantifying the Ease of Scientific Discovery.
Arbesman, Samuel
It has long been known that scientific output proceeds on an exponential increase, or more properly, a logistic growth curve. The interplay between effort and discovery is clear, and the nature of the functional form has been thought to be due to many changes in the scientific process over time. Here I show a quantitative method for examining the ease of scientific progress, another necessary component in understanding scientific discovery. Using examples from three different scientific disciplines - mammalian species, chemical elements, and minor planets - I find the ease of discovery to conform to an exponential decay. In addition, I show how the pace of scientific discovery can be best understood as the outcome of both scientific output and ease of discovery. A quantitative study of the ease of scientific discovery in the aggregate, such as done here, has the potential to provide a great deal of insight into both the nature of future discoveries and the technical processes behind discoveries in science.
Arthritis Genetics Analysis Aids Drug Discovery
... NIH Research Matters January 13, 2014 Arthritis Genetics Analysis Aids Drug Discovery An international research team identified 42 new ... Edition Distracted Driving Raises Crash Risk Arthritis Genetics Analysis Aids Drug Discovery Oxytocin Affects Facial Recognition Connect with Us ...
Bioinformatics for cancer immunotherapy target discovery
DEFF Research Database (Denmark)
Olsen, Lars Rønn; Campos, Benito; Barnkob, Mike Stein
therapy target discovery in a bioinformatics analysis pipeline. We describe specialized bioinformatics tools and databases for three main bottlenecks in immunotherapy target discovery: the cataloging of potentially antigenic proteins, the identification of potential HLA binders, and the selection epitopes...
Usability Test Results for a Discovery Tool in an Academic Library
Directory of Open Access Journals (Sweden)
Jody Condit Fagan
Full Text Available Discovery tools are emerging in libraries. These tools offer library patrons the ability to concurrently search the library catalog and journal articles. While vendors rush to provide feature-rich interfaces and access to as much content as possible, librarians wonder about the usefulness of these tools to library patrons. In order to learn about both the utility and usability of EBSCO Discovery Service, James Madison University conducted a usability test with eight students and two faculty members. The test consisted of nine tasks focused on common patron requests or related to the utility of specific discovery tool features. Software recorded participants' actions and time on task, human observers judged the success of each task, and a post-survey questionnaire gathered qualitative feedback and comments from the participants. Overall, participants were successful at most tasks, but specific usability problems suggested some interface changes for both EBSCO Discovery Service and JMU's customizations of the tool. The study also raised several questions for libraries above and beyond any specific discovery tool interface, including the scope and purpose of a discovery tool versus other library systems, working with the large result sets made possible by discovery tools, and navigation between the tool and other library services and resources. This article will be of interest to those who are investigating discovery tools, selecting products, integrating discovery tools into a library web presence, or performing evaluations of similar systems.
Introduction to the special collection of papers on the San Luis Basin Sustainability Metrics Project: a methodology for evaluating regional sustainability.
Heberling, Matthew T; Hopton, Matthew E
This paper introduces a collection of four articles describing the San Luis Basin Sustainability Metrics Project. The Project developed a methodology for evaluating regional sustainability. This introduction provides the necessary background information for the project, description of the region, overview of the methods, and summary of the results. Although there are a multitude of scientifically based sustainability metrics, many are data intensive, difficult to calculate, and fail to capture all aspects of a system. We wanted to see if we could develop an approach that decision-makers could use to understand if their system was moving toward or away from sustainability. The goal was to produce a scientifically defensible, but straightforward and inexpensive methodology to measure and monitor environmental quality within a regional system. We initiated an interdisciplinary pilot project in the San Luis Basin, south-central Colorado, to test the methodology. The objectives were: 1) determine the applicability of using existing datasets to estimate metrics of sustainability at a regional scale; 2) calculate metrics through time from 1980 to 2005; and 3) compare and contrast the results to determine if the system was moving toward or away from sustainability. The sustainability metrics, chosen to represent major components of the system, were: 1) Ecological Footprint to capture the impact and human burden on the system; 2) Green Net Regional Product to represent economic welfare; 3) Emergy to capture the quality-normalized flow of energy through the system; and 4) Fisher information to capture the overall dynamic order and to look for possible regime changes. The methodology, data, and results of each metric are presented in the remaining four papers of the special collection. Based on the results of each metric and our criteria for understanding the sustainability trends, we find that the San Luis Basin is moving away from sustainability. Although we understand
The circumstances of minor planet discovery
International Nuclear Information System (INIS)
Pilcher, F.
The circumstances of discoveries of minor planets are presented in tabular form. Complete data are given for planets 2125-4044, together with notes pertaining to these planets. Information in the table includes the permanent number; the official name; for planets 330 and forward, the table includes the provisional designation attached to the discovery apparition and the year, month, the day of discovery, and the discovery place
Violencia en estudiantes universitarios en San Luis Potosí, México: Un estudio desde la perspectiva de género Violence in college students at San Luis Potosi, Mexico: A study from gender perspective
Directory of Open Access Journals (Sweden)
Yesica Yolanda Rangel Flores
Full Text Available Objetivo: Identificar las correlaciones que se establecen entre género y autopercepción homicida y suicida en estudiantes de una universidad de la Región Media en San Luís Potosí, México. Metodología: Estudio transversal, descriptivo y correlacional; mediante muestreo probabilístico estratificado se seleccionaron 250 estudiantes a quienes se aplicó un instrumento creado ex profeso y validado (alfa=.78. Las variables de estudio fueron: agresión padecida, agresión ejercida e ideación homicida y suicida; el análisis de los resultados se realizó desde el enfoque de género. Resultados principales: El 15.6% de los estudiantes se identifican con perfil agresor, solo un 6% con perfil de víctima, los hombres más que mujeres canalizan la violencia a través de conductas agresoras hacia los demás (x2 11.262 p= .024, las mujeres practican más la ideación suicida (x2 10.832 p= .031. Conclusión: La conducta violenta se encontró relacionada al rol social de género, en los hombres dirigida hacia otros y en las mujeres en forma autoinfringida.Objective: Identify correlations between and homicidal and suicidal self-perception in student of a University in the middle region of San Luis Potosí, Mexico. Methods: A cross-sectional, descriptive and correlation study took place, by means of a sampling stratified probability instrument we selected 250 students who applied a purpose-built created and validated instrument (alpha=.78. The variables were: suffered aggression, exercised aggression and to devise suicidal/homicide. Results: The study showed that 15.6% of students identified themselves with the profile of an aggressor, while only 6 percent with a victim profile, men more than women channel violence through aggressive behavior towards others (x2 11.262 p= .024, while women practice more a suicidal ideation (x2 10.832 p= .031. Conclusions: Therefore, violent behavior was found related to the social role of gender, in men directed towards
... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Discovery. 280.210 Section 280.210... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE ACCREDITATION AND ASSESSMENT PROGRAMS FASTENER QUALITY Enforcement § 280.210 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery...
... 6 Domestic Security 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) In general. (1) The following types of discovery are authorized: (i) Requests for production of...
... 42 Public Health 5 2010-10-01 2010-10-01 false Discovery. 1005.7 Section 1005.7 Public Health... OF EXCLUSIONS, CIVIL MONEY PENALTIES AND ASSESSMENTS § 1005.7 Discovery. (a) A party may make a... and any forms of discovery, other than those permitted under paragraph (a) of this section, are not...
... 42 Public Health 2 2010-10-01 2010-10-01 false Discovery. 405.1037 Section 405.1037 Public Health... Appeals Under Original Medicare (Part A and Part B) Alj Hearings § 405.1037 Discovery. (a) General rules. (1) Discovery is permissible only when CMS or its contractor elects to participate in an ALJ hearing...
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 99.23 Section 99.23 Public Welfare... DEVELOPMENT FUND Hearing Procedures § 99.23 Discovery. The Department, the Lead Agency, and any individuals or groups recognized as parties shall have the right to conduct discovery (including depositions) against...
... 29 Labor 4 2010-07-01 2010-07-01 false Discovery. 1603.210 Section 1603.210 Labor Regulations... GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.210 Discovery. (a) Unless otherwise ordered by the administrative law judge, discovery may begin as soon as the complaint has been transmitted to the administrative...
... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Discovery. 60-30.33... 11246 Expedited Hearing Procedures § 60-30.33 Discovery. (a) Any party may serve requests for admissions... with § 60-30.8, the Administrative Law Judge may allow the taking of depositions. Other discovery will...
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 150.435 Section 150.435 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.435 Discovery. (a) The parties must identify any need for discovery from the opposing party as soon as possible, but no later than the time for...
... 10 Energy 4 2010-01-01 2010-01-01 false Discovery. 1013.21 Section 1013.21 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PROGRAM FRAUD CIVIL REMEDIES AND PROCEDURES § 1013.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and...
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Discovery. 355.21 Section 355.21 Employees... UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...
... 34 Education 1 2010-07-01 2010-07-01 false Discovery. 81.16 Section 81.16 Education Office of the... Discovery. (a) The parties to a case are encouraged to exchange relevant documents and information voluntarily. (b) The ALJ, at a party's request, may order compulsory discovery described in paragraph (c) of...
... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 2.1018 Section 2.1018 Energy NUCLEAR REGULATORY... Geologic Repository § 2.1018 Discovery. (a)(1) Parties, potential parties, and interested governmental participants in the high-level waste licensing proceeding may obtain discovery by one or more of the following...
... 45 Public Welfare 2 2010-10-01 2010-10-01 false Discovery. 213.23a Section 213.23a Public Welfare... Discovery. The Department and any party named in the notice issued pursuant to § 213.11 shall have the right to conduct discovery (including depositions) against opposing parties. Rules 26-37 of the Federal...
... 29 Labor 9 2010-07-01 2010-07-01 false Discovery. 2200.208 Section 2200.208 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION RULES OF PROCEDURE Simplified Proceedings § 2200.208 Discovery. Discovery, including requests for admissions, will only be...
... 47 Telecommunication 3 2010-10-01 2010-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...
... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Discovery. 71.21 Section 71.21 Judicial... REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...
... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.310 Section 134.310 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.310 Discovery. Discovery will not be permitted in appeals from size determinations or NAICS...
... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Discovery. 498.207 Section 498.207 Employees... § 498.207 Discovery. (a) For the purpose of inspection and copying, a party may make a request to...) Any form of discovery other than that permitted under paragraph (a) of this section, such as requests...
... 29 Labor 5 2010-07-01 2010-07-01 false Discovery. 1905.25 Section 1905.25 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.25 Discovery. (a) Depositions. (1) For reasons of... discovery. Whenever appropriate to a just disposition of any issue in a hearing, the presiding hearing...
... 34 Education 1 2010-07-01 2010-07-01 false Discovery. 33.21 Section 33.21 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying...
... 42 Public Health 1 2010-10-01 2010-10-01 false Discovery. 93.512 Section 93.512 Public Health... Process § 93.512 Discovery. (a) Request to provide documents. A party may only request another party to...) Responses to a discovery request. Within 30 days of receiving a request for the production of documents, a...
... 49 Transportation 4 2010-10-01 2010-10-01 false Discovery. 209.313 Section 209.313 Transportation... TRANSPORTATION RAILROAD SAFETY ENFORCEMENT PROCEDURES Disqualification Procedures § 209.313 Discovery. (a... parties. Discovery is designed to enable a party to obtain relevant information needed for preparation of...
... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Discovery. 1780.26 Section 1780.26 Banks and... OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Prehearing Proceedings § 1780.26 Discovery. (a) Limits on discovery. Subject to the limitations set out in paragraphs (b), (d), and (e) of this...
... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Discovery. 2.120 Section 2... COMMERCE RULES OF PRACTICE IN TRADEMARK CASES Procedure in Inter Partes Proceedings § 2.120 Discovery. (a... to disclosure and discovery shall apply in opposition, cancellation, interference and concurrent use...
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 160.516 Section 160.516 Public Welfare... ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.516 Discovery. (a) A party may make a request to... forms of discovery, other than those permitted under paragraph (a) of this section, are not authorized...
... 46 Shipping 9 2010-10-01 2010-10-01 false Discovery. 550.502 Section 550.502 Shipping FEDERAL... Proceedings § 550.502 Discovery. The Commission may authorize a party to a proceeding to use depositions, written interrogatories, and discovery procedures that, to the extent practicable, are in conformity with...
... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Discovery. 18.7 Section 18.7 Judicial Administration DEPARTMENT OF JUSTICE OFFICE OF JUSTICE PROGRAMS HEARING AND APPEAL PROCEDURES § 18.7 Discovery.... Such order may be entered upon a showing that the deposition is necessary for discovery purposes, and...
... 10 Energy 3 2010-01-01 2010-01-01 false Discovery. 205.198 Section 205.198 Energy DEPARTMENT OF... of Proposed Disallowance, and Order of Disallowance § 205.198 Discovery. (a) If a person intends to file a Motion for Discovery, he must file it at the same time that he files his Statement of Objections...
... 42 Public Health 1 2010-10-01 2010-10-01 false Discovery. 3.516 Section 3.516 Public Health PUBLIC... AND PATIENT SAFETY WORK PRODUCT Enforcement Program § 3.516 Discovery. (a) A party may make a request... and any forms of discovery, other than those permitted under paragraph (a) of this section, are not...
... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Discovery. 908.46 Section 908.46 Banks and... PRACTICE AND PROCEDURE IN HEARINGS ON THE RECORD Pre-Hearing Proceedings § 908.46 Discovery. (a) Limits on discovery. Subject to the limitations set out in paragraphs (b), (d), and (e) of this section, any party to...
... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Discovery. 785.8 Section 785.8... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS ENFORCEMENT § 785.8 Discovery. (a) General. The parties are encouraged to engage in voluntary discovery regarding any matter, not...
... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Discovery. 35.21 Section 35.21 Foreign Relations DEPARTMENT OF STATE CLAIMS AND STOLEN PROPERTY PROGRAM FRAUD CIVIL REMEDIES § 35.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...
... 29 Labor 1 2010-07-01 2010-07-01 true Discovery. 22.21 Section 22.21 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...
... 42 Public Health 4 2010-10-01 2010-10-01 false Discovery. 430.86 Section 430.86 Public Health... Plans and Practice to Federal Requirements § 430.86 Discovery. CMS and any party named in the notice issued under § 430.70 has the right to conduct discovery (including depositions) against opposing parties...
... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Discovery. 17.23 Section 17.23 Food and Drugs FOOD... HEARINGS § 17.23 Discovery. (a) No later than 60 days prior to the hearing, unless otherwise ordered by the..., depositions, and any forms of discovery, other than those permitted under paragraphs (a) and (e) of this...
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 96.65 Section 96.65 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Hearing Procedure § 96.65 Discovery. The use of interrogatories, depositions, and other forms of discovery shall not be allowed. ...
... 7 Agriculture 1 2010-01-01 2010-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...
... 45 Public Welfare 4 2010-10-01 2010-10-01 false Discovery. 1386.103 Section 1386.103 Public... Hearing Procedures § 1386.103 Discovery. The Department and any party named in the Notice issued pursuant to § 1386.90 has the right to conduct discovery (including depositions) against opposing parties as...
... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 79.21 Section 79.21 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...
... 49 Transportation 1 2010-10-01 2010-10-01 false Discovery. 31.21 Section 31.21 Transportation Office of the Secretary of Transportation PROGRAM FRAUD CIVIL REMEDIES § 31.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and...
... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Discovery. 308.520 Section 308.520 Banks and... PROCEDURE Program Fraud Civil Remedies and Procedures § 308.520 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for inspection and copying; (2) Requests...
... 47 Telecommunication 1 2010-10-01 2010-10-01 false Discovery. 1.729 Section 1.729..., and Reports Involving Common Carriers Formal Complaints § 1.729 Discovery. (a) Subject to paragraph (i... seek discovery of any non-privileged matter that is relevant to the material facts in dispute in the...
... 7 Agriculture 4 2010-01-01 2010-01-01 false Discovery. 283.12 Section 283.12 Agriculture... of $50,000 or More § 283.12 Discovery. (a) Dispositions—(1) Motion for taking deposition. Only upon a... exist if the information sought appears reasonably calculated to lead to the discovery of admissible...
Discovery of inhibitors of bacterial histidine kinases
Velikova, N.R.
Discovery of Inhibitors of Bacterial Histidine Kinases Summary
The thesis is on novel antibacterial drug discovery (http://youtu.be/NRMWOGgeysM). Using structure-based and fragment-based drug discovery approach, we have identified small-molecule histidine-kinase
29 CFR 18.13 - Discovery methods.
... 29 Labor 1 2010-07-01 2010-07-01 true Discovery methods. 18.13 Section 18.13 Labor Office of the... ADMINISTRATIVE LAW JUDGES General § 18.13 Discovery methods. Parties may obtain discovery by one or more of the following methods: Depositions upon oral examination or written questions; written interrogatories...
Modelo sistémico de planeamiento estratégico con enfoque de sustainability Scorecard aplicado a la Universidad Nacional San Luis Gonzaga
Cáceres Huamán, Juan Félix; Cáceres Huamán, Juan Félix; Cáceres Huamán, Juan Félix
En el presente trabajo de investigación, se expone la concepción sistémica del planeamiento estratégico, como metodología y herramienta de gestión empresarial, a fin que la Universidad Nacional "San Luis Gonzaga", logre una gestión estratégica, académica y administrativa, eficiente, eficaz y de calidad, para alcanzar un desarrollo y crecimiento sostenible. También se plantea la estrategia del balance de sostenibilidad (Sustainability Scorecard "SSC"), que postula la integración de lo econ...
Nacionalismo maya y descolonización política: Luis de Lión y El tiempo principia en Xibalbá
del Valle Escalante, Emilio; University of North Carolina, Chapel Hill
Este artículo analiza la novela El tiempo principia en Xibalbá (1985) del escritor maya kaqchikel Luis de Lión (1939-1984), considerada la primera novela escrita por un escritor maya en Guatemala. Leída como una de las primeras manifestaciones epistemológicas y políticas del llamado Movimiento Maya en Guatemala, la obra de Lión, como se argumenta en este trabajo, desmitifica y desarticula construcciones tradicionales y estereotipadas del mundo indígena en el discurso indigenista (la literatur...
La acción tutorial desde la perspectiva de los alumnos de la Universidad Autónoma de San Luis Potosí
Rubio, Perla Patricia; Martínez, José Francisco
Este estudio constituye una propuesta de corte cualitativo para explorar los ejes de racionalidad con que los alumnos de la Universidad Autónoma de San Luis Potosí (UASLP) construyen sus concepciones y expectativas, y analizan las implicaciones de la acción tutorial que los programas de tutoría implementan en su institución. De los resultados generados se encontró que los alumnos conceptualizan la acción tutorial en cinco ámbitos de atención: a) académico profesional, b) escolar y de aprendiz...
Análisis de la casuística de 5 años en la Unidad de Quemados del Hospital Luis Vernaza, Guayaquil, Ecuador
R. Guerrero-Torbay; J. Palacios-Martínez; P. Salamea-Molina; M. Gilbert-Orús; MT. Chiquito-Freile
En el periodo comprendido entre 2006 y 2010 registramos 646 ingresos a la Unidad de Quemados del Hospital Luis Vernaza, en Guayaquil, Ecuador. El género masculino fue más afectado que el femenino (70,7% frente a 29,3%). El domicilio fue el lugar donde más ocurrieron los accidentes. La llama fué la etiología más común (n=233). El 85% de los pacientes ingresados requirió algún tipo de tratamiento quirúrgico. La estancia media hospitalaria no tuvo diferencias al comparar género o edad, pero fue ...
Espetáculos e performances culturais no turismo: reflexões sobre o bumba-meu-boi em São Luis, Maranhão (Brasil
Directory of Open Access Journals (Sweden)
Karoliny Diniz Carvalho
Full Text Available This article examines the process of revitalization of cultures from the development of cultural tourism. Where the object of study, the Bumba-meu-boi in São Luis, Maranhao, discusses the major changes brought about in this play from its incorporation into the circuit of cultural production and consumption. Based on studies of performance and restoration of behavior, it is understood that the cultural events, like the Valley Celebrate event, consist of renovations on the identities of othercontexts and social spaces, and incorporating in this new meanings.
Modelo de sedimentación continental para el rift cretácico de la Argentina central: Ejemplo de la sierra de las Quijadas, San Luis
D. Rivarola; L. Spalletti
En este trabajo se estudian las sedimentitas continentales cretácicas (Grupo del Gigante) en la sierra de las Quijadas, ubicada en el noroeste de la provincia de San Luis. La información se obtuvo mediante el relevamiento de 15 perfiles sedimentológicos de detalle que permitieron definir 21 facies sedimentarias y 12 asociaciones de facies. Las facies permitieron interpretar los principales procesos de acumulación sedimentaria, mientras que a partir de las asociaciones de facies se propusieron...
Luis de León (1527-1591 y su teoría de la justicia: aspectos principales de su doctrina
Directory of Open Access Journals (Sweden)
Sebastián Contreras
Full Text Available Las investigaciones sobre Luis de León se han centrado, sobre todo, en su mística, narrativa y teoría literaria. En este trabajo, el autor intenta desarrollar los principales aspectos de su teoría jurídica. Al igual que otros grandes teólogos de la Escuela de Salamanca, también León ha estudiado el problema de la naturaleza de la ley humana y su vinculación con el derecho natural. Éste es, justamente, el tema del siguiente trabajo.