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Alias: Norway rat, brown rat, rats, Rattus norvegicus, Rattus sp. strain Wistar, Buffalo rat, Rattus PC12 clone IS, Sprague-Dawley rat, Wistar rats, laboratory rat, zitter rats, Gunn rats, Rattus rattiscus, Rattus norvegicus8, Rattus norwegicus
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Publications792 found, 100 shown here
- S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 bindingMakoto R Hara
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Nat Cell Biol 7:665-74. 2005..The NO-S-nitrosylation-GAPDH-Siah1 cascade may represent an important molecular mechanism of cytotoxicity...
- SynCAM, a synaptic adhesion molecule that drives synapse assemblyThomas Biederer
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 297:1525-31. 2002....
- Integrins: bidirectional, allosteric signaling machinesRichard O Hynes
Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 110:673-87. 2002..Long-range conformational changes couple these functions via allosteric equilibria...
- ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperaturesGina M Story
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Cell 112:819-29. 2003..Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol...
- Cloning of adiponectin receptors that mediate antidiabetic metabolic effectsToshimasa Yamauchi
Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
Nature 423:762-9. 2003....
- LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingY Kabeya
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, PRESTO, Japan
EMBO J 19:5720-8. 2000..Here we demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is ..
- Release of chromatin protein HMGB1 by necrotic cells triggers inflammationPaola Scaffidi
DIBIT, Istituto Scientifico San Raffaele, 20132 Milano, Italy
Nature 418:191-5. 2002..Thus, cells undergoing apoptosis are programmed to withhold the signal that is broadcast by cells that have been damaged or killed by trauma...
- Shared principles in NF-kappaB signalingMatthew S Hayden
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 132:344-62. 2008..Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation...
- Calcium signalingDavid E Clapham
Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
Cell 131:1047-58. 2007..Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription...
- RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's diseaseS D Yan
Department of Pathology, Columbia University, College of Physicians and Surgeons, New York 10032, USA
Nature 382:685-91. 1996..Increased expressing of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death...
- The capsaicin receptor: a heat-activated ion channel in the pain pathwayM J Caterina
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
Nature 389:816-24. 1997..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
- A transgenic model of visceral obesity and the metabolic syndromeH Masuzaki
Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
Science 294:2166-70. 2001..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
- International union of pharmacology. XXIII. The angiotensin II receptorsM De Gasparo
Novartis Pharma AG, Metabolic and Cardiovascular Diseases, Basel, Switzerland
Pharmacol Rev 52:415-72. 2000..The development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system...
- Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesUmut Ozcan
Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
Science 306:457-61. 2004..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
- Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisManuela Neumann
Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Science 314:130-3. 2006..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
- Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54Nicolas de Roux
Institut National de la Santé et de la Recherche Médicale Unité 135, Unité de Recherches Hormones Gènes et Reproduction, Hopital de Bicetre, 94275 Le Kremlin Bicetre, France
Proc Natl Acad Sci U S A 100:10972-6. 2003..The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis...
- Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)H Cho
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 292:1728-31. 2001..These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis...
- Identification of a cold receptor reveals a general role for TRP channels in thermosensationDavid D McKemy
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
Nature 416:52-8. 2002....
- Control of synaptic strength by glial TNFalphaEric C Beattie
Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
Science 295:2282-5. 2002..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
- Identification of ubiquitin ligases required for skeletal muscle atrophyS C Bodine
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
Science 294:1704-8. 2001..Although many genes were up-regulated in a single rat model of atrophy, only a small subset was universal in all atrophy models...
- Mechanisms of TGF-beta signaling from cell membrane to the nucleusYigong Shi
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA
Cell 113:685-700. 2003..This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus...
- The widespread regulation of microRNA biogenesis, function and decayJacek Krol
Friedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland
Nat Rev Genet 11:597-610. 2010..Such regulation has an important role in the context-specific functions of miRNAs...
- Mutation of the mouse klotho gene leads to a syndrome resembling ageingM Kuro-O
Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
Nature 390:45-51. 1997..The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases...
- Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionG L Wang
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
Proc Natl Acad Sci U S A 92:5510-4. 1995....
- Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaT Nakagawa
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 403:98-103. 2000..Thus, caspase-12 mediates an ER-specific apoptosis pathway and may contribute to amyloid-beta neurotoxicity...
- Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegenerationLibin Cui
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
Cell 127:59-69. 2006..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
- Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorT Sakurai
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
Cell 92:573-85. 1998..When administered centrally to rats, these peptides stimulate food consumption...
- Hypothalamic mTOR signaling regulates food intakeDaniela Cota
Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
Science 312:927-30. 2006..In the rat, mTOR signaling is controlled by energy status in specific regions of the hypothalamus and colocalizes with ..
- Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BD A Cross
MRC Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, UK
Nature 378:785-9. 1995..Like the inhibition of GSK3 (refs 10, 14), the activation of PKB is prevented by inhibitors of phosphatidylinositol (PI) 3-kinase...
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Heon Park
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1133-41. 2005..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
- Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryGanesh M Shankar
Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 14:837-42. 2008..Soluble Abeta from Alzheimer's disease brain also disrupted the memory of a learned behavior in normal rats. These various effects were specifically attributable to Abeta dimers...
- TLR4 links innate immunity and fatty acid-induced insulin resistanceHang Shi
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 116:3015-25. 2006....
- Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivityS Hattar
Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
Science 295:1065-70. 2002..By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and ..
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- A serum shock induces circadian gene expression in mammalian tissue culture cellsA Balsalobre
Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, Switzerland
Cell 93:929-37. 1998The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of serum induces the circadian expression of various genes whose transcription also oscillates in living animals...
- Lasting epigenetic influence of early-life adversity on the BDNF geneTania L Roth
Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
Biol Psychiatry 65:760-9. 2009Childhood maltreatment and early trauma leave lasting imprints on neural mechanisms of cognition and emotion. With a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic ..
- Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and betaG G Kuiper
Center for Biotechnology, Karolinska Institute, Huddinge, Sweden
Endocrinology 138:863-70. 1997The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain...
- A calcineurin-dependent transcriptional pathway for cardiac hypertrophyJ D Molkentin
Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center at Dallas, 75225 9148, USA
Cell 93:215-28. 1998..Pharmacologic inhibition of calcineurin activity blocks hypertrophy in vivo and in vitro. These results define a novel hypertrophic signaling pathway and suggest pharmacologic approaches to prevent cardiac hypertrophy and heart failure...
- Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismChunming Liu
Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Cell 108:837-47. 2002..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
- Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentHsiuchen Chen
Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
J Cell Biol 160:189-200. 2003..Therefore, mitochondrial fusion is essential for embryonic development, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population...
- An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signalingSoren Impey
Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA
Mol Cell Neurosci 43:146-56. 2010..These data suggest that neuronal activity regulates spine formation, in part, by increasing miR132 transcription, which in turn activates a Rac1-Pak actin remodeling pathway...
- SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteinsDavid C Schultz
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:919-32. 2002..Thus, KAP-1 is a molecular scaffold that is targeted by KRAB-ZFPs to specific loci and coordinates both histone methylation and the deposition of HP1 proteins to silence gene expression...
- Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsKrishna M Vattem
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 101:11269-74. 2004..These results suggest that the mechanism of translation reinitiation involving uORFs is conserved from yeast to mammals...
- A transmembrane intracellular estrogen receptor mediates rapid cell signalingChetana M Revankar
Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Science 307:1625-30. 2005..Thus, GPR30 represents an intracellular transmembrane estrogen receptor that may contribute to normal estrogen physiology as well as pathophysiology...
- Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroliginsEthan R Graf
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Cell 119:1013-26. 2004....
- Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinibThomas J Lynch
Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
N Engl J Med 350:2129-39. 2004..However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms underlying sensitivity to gefitinib are unknown...
- The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismJeffrey A Engelman
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Genet 7:606-19. 2006..In light of the recent advances in our understanding of the function of PI3Ks in the pathogenesis of diabetes and cancer, we discuss the exciting therapeutic opportunities for targeting this pathway to treat these diseases...
- Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1F Urano
Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology and the Kaplan Cancer Center, New York University Medical School, New York, NY 10016, USA
Science 287:664-6. 2000..Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals...
- Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisD R Rosen
Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown 02129
Nature 362:59-62. 1993..Given this linkage and the potential role of free radical toxicity in other neurodenegerative disorders, we investigated SOD1 as a candidate gene in FALS. We identified 11 different SOD1 missense mutations in 13 different FALS families...
- Regulation of cell survival by secreted proneurotrophinsR Lee
Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Science 294:1945-8. 2001..The biological action of neurotrophins is thus regulated by proteolytic cleavage, with proforms preferentially activating p75NTR to mediate apoptosis and mature forms activating Trk receptors to promote survival...
- Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4Yunhui Cheng
RNA and Cardiovascular Research Laboratory, Department of Anesthesiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, MSB E548, Newark, NJ 07101, USA
Cardiovasc Res 87:431-9. 2010The aims of the present study are to determine the miRNA expression signature in rat hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in IP-mediated cardiac protection, and the potential cellular ..
- Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoWesley Farris
Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:4162-7. 2003..region containing a mutant IDE allele has been associated with hyperinsulinemia and glucose intolerance in a rat model of DM2. Human genetic studies have implicated the IDE region of chromosome 10 in both AD and DM2...
- A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex developmentAtsushi Kamiya
Department of Psychiatry Neurobiology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, CMSC 8 117, Baltimore, MD 21287, USA
Nat Cell Biol 7:1167-78. 2005..These results indicate that DISC1 is involved in cerebral cortex development, and suggest that loss of DISC1 function may underlie neurodevelopmental dysfunction in schizophrenia...
- BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic painJeffrey A M Coull
Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
Nature 438:1017-21. 2005..Blocking this microglia-neuron signalling pathway may represent a therapeutic strategy for treating neuropathic pain...
- Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturationZhaolan Zhou
Neurobiology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Neuron 52:255-69. 2006....
- Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1Akiko Hayashi-Takagi
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 13:327-32. 2010..the duration and intensity of Rac1 activation in response to NMDA receptor activation in both cortical cultures and rat brain in vivo...
- Two genes encode distinct glutamate decarboxylasesM G Erlander
Neuroscience Program, University of California Los Angeles 90024
Neuron 7:91-100. 1991..The distinctive properties of the two GADs provide a substrate for understanding not only the multiple roles of GABA in the nervous system, but also the autoimmune response to GAD in insulin-dependent diabetes mellitus...
- CREB regulates hepatic gluconeogenesis through the coactivator PGC-1S Herzig
Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
Nature 413:179-83. 2001..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
- A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiationAryaman Shalizi
Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
Science 311:1012-7. 2006..Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain...
- Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in miceN G Larsson
Department of Molecular Medicine, Center for Molecular Medicine L8 02, Stockholm, Sweden
Nat Genet 18:231-6. 1998..5. Thus, Tfam is the first mammalian protein demonstrated to regulate mtDNA copy number in vivo and is essential for mitochondrial biogenesis and embryonic development...
- Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2Ha Won Kim
Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Biol Chem 284:33161-8. 2009..Extrapolation of these data to in vivo studies in a rat model of acute myocardial infarction predominantly improved stem cell survival after engraftment with a role for ..
- Developmental and regional expression in the rat brain and functional properties of four NMDA receptorsH Monyer
Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
Neuron 12:529-40. 1994An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts display distinct expression patterns...
- The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54M Kotani
Institut de Recherche Interdisciplinare en Biologie Humaine et Nucléaire I R I B H N, Brussels, Belgium
J Biol Chem 276:34631-6. 2001..Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis.
- The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolY Ye
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 414:652-6. 2001..We propose that the Cdc48/p97-Ufd1-Npl4 complex extracts proteins from the ER membrane for cytosolic degradation...
- The kinase domain of titin controls muscle gene expression and protein turnoverStephan Lange
Muscle Signalling and Development, Randall Division, King s College London, London SE1 1UL, UK
Science 308:1599-603. 2005..A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway...
- Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2Wen G Chen
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 302:885-9. 2003..These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T...
- Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenzaJesus F Bermejo-Martin
National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
Crit Care 13:R201. 2009..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
- Neuropilin is a semaphorin III receptorA L Kolodkin
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
Cell 90:753-62. 1997..We also describe the identification of neuropilin-2, a related neuropilin family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system.
- RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORsD M Sabatini
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Cell 78:35-43. 1994..We propose that RAFT1 is the direct target of FKBP12-rapamycin and a mammalian homolog of the TOR proteins...
- Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseM H Polymeropoulos
Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 1430, USA
Science 276:2045-7. 1997..This finding of a specific molecular alteration associated with PD will facilitate the detailed understanding of the pathophysiology of the disorder...
- Disruption of two novel genes by a translocation co-segregating with schizophreniaJ K Millar
Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Molecular Medicine Centre and MRC Human Genetics Unit, both at Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
Hum Mol Genet 9:1415-23. 2000..Altogether, these observations indicate that DISC1 and DISC2 should be considered formal candidate genes for susceptibility to psychiatric illness...
- Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3L Alexopoulou
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
Nature 413:732-8. 2001..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
- Homer: a protein that selectively binds metabotropic glutamate receptorsP R Brakeman
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 386:284-8. 1997..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling...
- Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptorsJ C Tu
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuron 21:717-26. 1998..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function...
- Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activationK P Hoeflich
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
Nature 406:86-90. 2000..Thus, GSK-3beta facilitates NF-kappaB function...
- Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channelsZhi Gang Xiong
Robert S Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA
Cell 118:687-98. 2004..Thus, acidosis injures the brain via membrane receptor-based mechanisms with resultant toxicity of [Ca2+]i, disclosing new potential therapeutic targets for stroke...
- Subunit arrangement and function in NMDA receptorsHiroyasu Furukawa
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, New York 10032, USA
Nature 438:185-92. 2005....
- LTP inhibits LTD in the hippocampus via regulation of GSK3betaStephane Peineau
MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
Neuron 53:703-17. 2007..In rat hippocampal slices, GSK3beta inhibitors block the induction of LTD...
- Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesisCagla Eroglu
Duke University Medical Center, Cell Biology Department, Durham, NC 27710, USA
Cell 139:380-92. 2009..These findings identify alpha2delta-1 as a receptor involved in excitatory synapse formation and suggest that gabapentin may function therapeutically by blocking new synapse formation...
- Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolutionR B Sutton
The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Nature 395:347-53. 1998..These characteristics may be important for membrane fusion and for the binding of regulatory factors affecting neurotransmission...
- Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarctionDaniel F Gudbjartsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 41:342-7. 2009..2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls)...
- Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failureHyun Ju Kim
Division of Nephrology and Hypertension, University of California, Irvine, California, USA
Am J Physiol Renal Physiol 298:F662-71. 2010..Subgroups of male Sprague-Dawley rats were subjected to 5/6 nephrectomy or sham operation and observed for 6 or 12 wk...
- Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expressionMichael McMahon
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 278:21592-600. 2003..We now report that Keap1 also controls the total cellular level of Nrf2 protein. In the RL34 non-transformed rat liver cell line, Nrf2 was found to accumulate rapidly in response to oxidative stress caused by treatment with ..
- TGF-beta signal transductionJ Massague
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Annu Rev Biochem 67:753-91. 1998..Mutations in these pathways are the cause of various forms of human cancer and developmental disorders...
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseR Sherrington
Department of Medicine Neurology, University of Toronto, Ontario, Canada
Nature 375:754-60. 1995..Because these changes occurred in conserved domains of this gene, and are not present in normal controls, they are likely to be causative of AD3...
- A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60X Cao
The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
Science 293:115-20. 2001..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
- Human hypertension caused by mutations in WNK kinasesF H Wilson
Howard Hughes Medical Institute Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06510 USA
Science 293:1107-12. 2001..WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs...
- Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseAndrew L Carey
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
Diabetes 55:2688-97. 2006..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
- Transforming growth factor-β1 induces matrix metalloproteinase-9 and cell migration in astrocytes: roles of ROS-dependent ERK- and JNK-NF-κB pathwaysHsi Lung Hsieh
Department of Nursing, Division of Basic Medical Sciences, Chang Gung Institute of Technology, Tao Yuan, Taiwan
J Neuroinflammation 7:88. 2010..Both TGF-β and MMPs have been shown to play crucial roles in brain pathological changes. Thus, we investigated the molecular mechanisms underlying TGF-β1-induced MMP-9 expression in brain astrocytes...
- ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsHideki Nishitoh
Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Bunkyo ku 113 8549, Japan
Genes Dev 16:1345-55. 2002..These findings suggest that ASK1 is a key element in ER stress-induced cell death that plays an important role in the neuropathological alterations in polyQ diseases...
- Identification and characterization of the vesicular GABA transporterS L McIntire
Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, Department of Neurology, UCSF School of Medicine, San Francisco, California 94143 0435, USA
Nature 389:870-6. 1997..Further, a rat homologue of unc-47 is expressed by central GABA neurons and confers vesicular GABA transport in transfected cells ..
- Early stress evokes age-dependent biphasic changes in hippocampal neurogenesis, BDNF expression, and cognitionDeepika Suri
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
Biol Psychiatry 73:658-66. 2013..While early life stress evokes persistent changes in anxiety, it is unknown whether early stress differentially regulates hippocampal neurogenesis, trophic factor expression, and cognition across the life span...
- The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous systemO Hori
Department of Physiology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 270:25752-61. 1995..Amphoterin purified from rat brain or recombinant rat amphoterin bound to purified sRAGE in a saturable and dose-dependent manner, blocked by ..
- Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injuryWon K Han
Medical Services, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Kidney Int 62:237-44. 2002..and mucin domain, whose expression is markedly up-regulated in the proximal tubule in the post-ischemic rat kidney. The ectodomain of KIM-1 is shed from cells...
- miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodelingRudy F Duisters
Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
Circ Res 104:170-8, 6p following 178. 2009....
- Translational control of C/EBPalpha and C/EBPbeta isoform expressionC F Calkhoven
Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
Genes Dev 14:1920-32. 2000..Our results demonstrate that the translational controlled ratio of C/EBPalpha and C/EBPbeta isoform expression determines cell fate...
- Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathwayYuekui Li
Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Neurosci 23:1605-11. 2003....
- Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male ratMichael S Irwig
Department of Medicine, University of Washington, Seattle, WA, USA
Neuroendocrinology 80:264-72. 2004..kisspeptins on gonadotropin secretion, we injected kisspeptin-52 into the lateral cerebral ventricles of adult male rats and found that kisspeptin-52 increased the serum levels of luteinizing hormone (p < 0.05)...
- Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosisFilip A Konopacki
Medical Research Council Centre for Synaptic Plasticity, University of Bristol, Bristol BS8 1TD, United Kingdom
Proc Natl Acad Sci U S A 108:19772-7. 2011..Thus, direct phosphorylation by PKC and GluK2 SUMOylation are intimately linked in regulating the surface expression and function of GluK2-containing KARs...
- Heteromeric NMDA receptors: molecular and functional distinction of subtypesH Monyer
Center for Molecular Biology, University of Heidelberg, Germany
Science 256:1217-21. 1992..Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence...
- Cloning of a novel receptor expressed in rat prostate and ovaryG G Kuiper
Center for Biotechnology and Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden
Proc Natl Acad Sci U S A 93:5925-30. 1996We have cloned a novel member of the nuclear receptor superfamily. The cDNA of clone 29 was isolated from a rat prostate cDNA library and it encodes a protein of 485 amino acid residues with a calculated molecular weight of 54.2 kDa...
Research Grants145 found, 100 shown here
- Quantitative MRI-based Assessment of Aerosol Deposition in the LungChantal Darquenne; Fiscal Year: 2009..Six weeks prior to aerosol exposure, emphysema will be induced in Wistar rats by intratracheal instillation of pancreatic elastase...
- Neurobiological basis of Depression as a Comorbidity in EpilepsyAndrey M Mazarati; Fiscal Year: 2010..To induce TLE, two weeks-old Wistar rats will be subjected to LiCl and pilocarpine status epilepticus (SE)...
- Emotional learning-induced changes of neuronal representations in the hippocampalAlmira Vazdarjanova; Fiscal Year: 2010..inactivating the BLA before contextual fear conditioning results in high overlap in CA3 and CA1, similar to that of rats that have explored the context twice, but have not received footshock in it...
- Ethanol's Influence on Neural Mechanisms of NavigationRobert Stackman; Fiscal Year: 2009..Previous behavioral studies have shown that acute ethanol disrupts spatial memory in rats and mice. In contrast, acute ethanol has minimal effects on the spatial firing of hippocampal neurons (place cells)...
- THERAPEUTIC MOTOR TRAINING AND FETAL ALCOHOL EFFECTSWilliam T Greenough; Fiscal Year: 2010..for post-weaning cytogenesis in adolescence and young adulthood is present, even enhanced, in the motor cortex of rats given binge-like alcohol exposure during the neonatal period of rapid brain growth, compared to unexposed controls...
- GABA-B Receptor Modulation of Calcium CurrentsMichelle Mynlieff; Fiscal Year: 2010..is that L-type current is facilitated in response to GABAB receptor activation in the neonatal neurons of the rat hippocampus...
- Juvenile trophic factors for the prevention and treatment of hippocampal agingJan Krzysztof Blusztajn; Fiscal Year: 2010..This cholinergic innervations develops during the first two postnatal weeks in rats and mice but its function declines in aging brain...
- The role of the circadian clock in encoding seasonal variations in day lengthJULIE SUZANNE PENDERGAST; Fiscal Year: 2010..be determined whether photoperiod encoding in the SCN differs between photoperiodic F344 and nonphotoperiodic Wistar rats. Seasonal variations in photoperiod may also affect neurological processes in humans...
- Na/Bicarbonate Cotransporters in BrainMARK OLIVER BEVENSEE; Fiscal Year: 2010..a-H exchangers (NHEs)) in cult ured astroc)'tes and neurons from rat hippocampus (Aim I). Int racellular P I P ~ levels will be altered in cells by di rect perfusion...
- Pro-inflammatory glucocorticoid effects in the CNSRobert M Sapolsky; Fiscal Year: 2010..In all experiments, intact rats will be exposed to either LPS, a bacteria-derived molecule which stimulates a robust inflammatory response, or a ..
- Anti-Aging Mitochondrial Protein Therapy for Alzheimer?s Disease and SarcopeniaJAMES PEPPER BENNETT; Fiscal Year: 2010..pre- clinical Investigational New Drug (IND)studies for the FDA/CDER (Center for Drug Evaluation and Research): (i) Rat CNS (Irwin study), respiratory, dose range finding, and repeat dose 1 month;(ii) Dog cardiovascular, dose range ..
- Broadly Neuroprotective Drug for TBIFernando Gomez Pinilla; Fiscal Year: 2010..of a broad-spectrum drug for TBI and to determine its potential mechanisms using fluid percussion injury model in rats. We have a comprehensive approach to evaluate the ability of CNB-001 to restore synaptic plasticity and energy ..
- Functional Activity Mapping of Brain NetworksCarol A Barnes; Fiscal Year: 2010..exhibited by the hippocampus influences the neocortical layers to which the hippocampus projects in young and aged rats. We expect that the outcome of the proposed project will have an important impact on our understanding of the ..
- Role of Metallothioneins in Isoflurane-Preconditioning of neurons in vitro.Adam C Hall; Fiscal Year: 2010..work from my lab identified metallothionein I + II genes (MT-I + II) as among those significantly regulated in rat liver, kidney and heart following a 2% isoflurane exposure in vivo (Edmands et al., 2005)...
- Food(cassava) cyanogen exposure and motor neuron degenerationDANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010..and assess changes in selected indicators of protein misfolding in brain/spinal cord tissues of young Wistar rats kept on SAA-deficient diets and treated with linamarin, NaOCN (positive control) or equivalent amount of 5% ..
- Resveratrol for Enriching Neurogenesis &Memory in the AgedAshok K Shetty; Fiscal Year: 2011..1, we will quantify the efficacy of long-term (28 days) administration of different doses of Resveratrol in aged rats for stimulating the proliferation of NSCs and increasing the extent of hippocampal neurogenesis...
- Gene Expression in Hippocampal Circuits of Bipolars and SchizophrenicsFrancine M Benes; Fiscal Year: 2011..the amygdala will also be used to evaluate whether genes showing overlapping changes in BDs, SZs and PICRO-treated rats may be related to amygdalar activation of the HIPP...
- Postnatal SSRI treatment: effects on serotonergic projections and gene expressionNeil Allen Gray; Fiscal Year: 2012..the postnatal period has been shown to produce opposing alterations in the emotional behavior of adult mice and rats. It has therefore been hypothesized that alterations of serotonin signaling during a developmental critical period ..
- Gender Differences in the Neural Circuitry of AddictionCatherine S Woolley; Fiscal Year: 2011..a combination of light and electron microscopy, western blotting, and whole-cell patch camp electrophysiology in rats to investigate whether and how chronic cocaine-induced changes in the dendritic arbor of nucleus accumbens neurons ..
- Neuroprotective strategies in seizure-induced damageJANA VELISKOVA; Fiscal Year: 2011..This protection occurs only in female but not in male rats. Preliminary studies have shown that neuroprotection is associated with increased late phase inhibition in the ..
- Neurobiological Correlates of Stress and Norepinephrine TransporterMeng Yang Zhu; Fiscal Year: 2012..Similar results are also found in rats and cultured cells, which were treated with or exposed to stress-relevant doses of corticosterone...
- Nicotinic receptors: Role in hippocampal synaptic functionEdson X Albuquerque; Fiscal Year: 2012..Reduced activity of these nAChRs impairs cognition in rats and mice, and has been proposed to contribute to the cognitive deficits observed in patients with schizophrenia and ..
- Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic MeasuresKENNETH W GRASING; Fiscal Year: 2012..Pretreatment with tacrine can produce long-lasting reductions in cocaine-reinforced behavior in rats, described as persistent attenuation (cocaine self-administration is decreased by more than 80% over a period of ..
- Prefrontal-Amygdala Interactions in Fear ConditioningGregory J Quirk; Fiscal Year: 2012..this grant show that the infralimbic prefrontal cortex (IL) plays a key role in the consolidation of extinction in rats. Neurons in IL exhibit NMDA receptor-dependent bursting immediately after extinction, and this bursting is ..
- GLUCOREGULATORY HORMONE INTERACTIONS IN DIABETESROBERT STANLEY SHERWIN; Fiscal Year: 2012..We will also examine the mechanisms for improved cognitive performance in rats after long-term exposure to recurrent hypoglycemia using MR spectroscopy as well as genomic and proteomic analyses...
- Interaction of Estrogen and AMPK in the HypothalamusJessica Healy; Fiscal Year: 2012..Activation of AMPK results in an increase in food intake. Ovariectomized female rats (lacking estradiol) become obese and have increased expression of hypothalamic pAMPK;however, the mechanism by ..
- GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place CellsTARA MONIQUE STEWART; Fiscal Year: 2012..is aimed at understanding the network mechanisms that accompany place field representations in adult and ASMI rats that may be modulated via pharmacological and genetic methods to enhance cognitive performance...
- Neural Grafts and Injury-Induced Hippocampal DysfunctionAshok K Shetty; Fiscal Year: 2010..video-electroencephalographic (video-EEC), and learning and memory analyses in young adult F344 rats undergoing intraperitoneal kainic acid induced acute seizures and hippocampal injury, a model of temporal lobe ..
- The Role of Local BDNF Synthesis in Spine MorphogenesisLAUREN LYNN OREFICE; Fiscal Year: 2012..In this assay, actin-GFP-labeled spines of cultured rat hippocampal neurons form during the first 2 weeks, mature during weeks 3 and 4, and are pruned during week 4...
- Robert S Fujinami; Fiscal Year: 2016..Previous animal models have infected rabbits, rats and mice with different viruses...
- John F Disterhoft; Fiscal Year: 2016..We have recently shown that the learning-related AHP reduction in young adult rats is mediated in part by protein kinase A (PKA) activity, known to activate CREB and subsequent gene transcription/..
- Paula C Bickford; Fiscal Year: 2014..inflammation in the cerebellum by infusing TNF1 disrupts cerebellar synaptic plasticity (motor learning) in young rats while blocking TNF1 in aged rats modestly improves motor learning...
- PCB Disruption of Thyroid Hormone Action during DevelopmentROBERT THOMAS ZOELLER; Fiscal Year: 2013..Specific metabolites will be tested for their ability to bind to rat and human TR11 and TR21 isoforms...
- Adolescent Alcohol,Dysregulated Stress System, and PTSD VulnerabilityGERHARD H SCHULTEIS; Fiscal Year: 2013..In Specific Aim 1, young adult male Wistar rats will be exposed to one of several conditions of social defeat stress (Nondefeat Control, 3x, 6x, or 9x defeat ..
- Hal Blumenfeld; Fiscal Year: 2016..In support of this, we recently found in a rat model that spontaneous and induced limbic seizures exhibit high frequency discharges in the hippocampus, but slow 1-..
- William J McBride; Fiscal Year: 2016..within the limbic system, selected experiments will be conducted with alcohol-preferring (P) rats and stock Wistar rats. The results of this project will provide important information on (a) CNS sites and receptors mediating the ..
- Susan M Lunte; Fiscal Year: 2015..Three experimental models of epilepsy will be used in Wistar rats. The first two models use 3-mercaptopropionic acid (3-MPA) to chemically induce seizures in a controlled manner...
- JOSEPH D WALCH; Fiscal Year: 2014..role of renin-angiotensin system in supporting the chronic activation of vasopressin neurons in bile duct ligated rats. 2: Test the hypothesis that increased expression of ?FosB produces cellular adaptations that contribute to ..
- Gregory J Morton; Fiscal Year: 2016..suggests that induction of hyperleptinemia fully ameliorates hyperglycemia in streptozotocin (STZ)-induced diabetic rats and our recent findings implicate the brain in this effect...
- KENICHIRO HAYASHIDA; Fiscal Year: 2014..locus coeruleus (LC) neurons via glutamatergic signaling and that the anti-hypersensitivity effects of GBP in rats with peripheral nerve injury relies on this activation and subsequent spinal NA release...
- Opposing Effects of Chronic Stress on Amygdala and HippocampusKi Ann Goosens; Fiscal Year: 2013..cutting-edge molecular methods (viral-mediated gene transfer) with immunohistochemical and behavioral techniques in rats to further examine this hypothesis and explore two mechanisms by which opposing effects may occur...
- Scott M Thompson; Fiscal Year: 2016..The effects of 5-HT1B receptor activation on TA-CA1 synaptic transmission are enhanced in rats subjected to chronic unpredictable stress (CUS), an accepted animal model of depression, and blocked by chronic ..
- Thomas A Blanpied; Fiscal Year: 2016..In cultured neurons from rat hippocampus, we will use quantitative fluorescence microscopy along with patch-clamp electrophysiology, photolysis, ..
- Michael K Georgieff; Fiscal Year: 2015..We propose to perform studies in iron deficient anemic rat pups and 2 genetic mouse models of ID...
- Robert W Wiseman; Fiscal Year: 2016..Data will be obtained from male Wistar rats (normoglycemic) and the Goto Kakizaki rat model of T2D (hyperglycemic) to identify functional differences ..
- Kechen Zhang; Fiscal Year: 2015..In rats, one particular kind of oscillation referred to as "theta rhythm" is very predominant in the hippocampus and ..
- Andrey M Mazarati; Fiscal Year: 2016..We will employ a model of chronic epilepsy that develops in male Wistar rats following pilocarpine - induced status epilepticus (SE)...
- Youssef Sari; Fiscal Year: 2015..We will also investigate the effects of GLT1 activation in EtOH-drinking behavior in Wistar rats as comparison control groups...
- Role of Endoplasmic Reticulum Stress in Obesity-Related Endothelial DysfunctionCHRISTOPHER GENTILE; Fiscal Year: 2013..Aim 2 will examine if a high saturated fat diet induces ER stress in the vasculature of male Wistar rats, and if so, whether this ER stress mediates endothelial dysfunction that results from such a diet...
- MeCP2 regulation on LINE-1 retrotransposition in neuronsCharles A Thomas; Fiscal Year: 2013..gametogenesis and in neoplastic processes, but recent studies have shown L1s are extremely active in the mouse, rat, and human neuronal progenitor cells (NPCs)...
- Interaction of BPA and soy isoflavones on sociosexual behaviorHeather B Patisaul; Fiscal Year: 2013..Preliminary data from this laboratory reveal that many of these adverse behavioral effects do not manifest in Wistar rats maintained on a soy-rich diet, suggesting that soy isoflavones, such as genistein (GEN) have potentially ..
- JEROME NONE ENGEL; Fiscal Year: 2016..We now have acquired evidence from several chronic rat models of human mesial temporal lobe epilepsy (MTLE), and from patients with MTLE, suggesting that pHFOs are ..
- LORI LYNN MCMAHON; Fiscal Year: 2015....
- E Sherwood Brown; Fiscal Year: 2014..Icariin, a flavonoid from Epimedium, 1) blocks the effects of corticosteroid-induced apoptosis in primary cultured rat hippocampal neurons, 2) is neuroprotective in animal models of ischemia, 3) improves memory in animal models of ..
- Virginia Gao; Fiscal Year: 2015..Blocking glycogenolysis in the rat hippocampus impairs memory...
- Olivier Thibault; Fiscal Year: 2016..Specific Aim # 1 will study F344 male rats fed a normal diet and determine, at 7-8 and 18-20 months of age, which component of metabolic dysregulation most ..
- Jill M Daniel; Fiscal Year: 2016..receptors, ER[unreadable], or both on the ability of short-term estradiol exposure in middle-aged ovariectomized rats to exert lasting impacts on ER[unreadable] target genes and associated proteins in the hippocampus and on ..
- Estradiol and Hippocampal DevelopmentMargaret M McCarthy; Fiscal Year: 2013..The goal of this proposal is to explore the novel observation of higher rates of cell genesis in the neonatal male rat hippocampus compared to the female, and an increase in cell genesis by exogenous estradiol treatment...
- Daniel Johnston; Fiscal Year: 2016..the HCN1 subunit for h channels in dorsal hippocampus produces anti-depression and anti-anxiety like behaviors in rats. From the clinical literature there appears to be a strong co-morbidity for depression and anxiety in epilepsy...
- DAVID NATHANIEL LINSENBARDT; Fiscal Year: 2015..P rats) and in a rat population with average genetic susceptibility to excessive alcohol consumption (Wistar rats)...
- SYNAPTIC SUBSTRATES OF AGE-DEPENDENT MEMORY DEFICITSJohn F Disterhoft; Fiscal Year: 2013..The basic strategy of the proposed research is to diagnose aged rats as either impaired or unimpaired using two hippocampus-dependent tasks, and then examine the morphology, receptor ..
- Neural Control of Vasopressin ReleaseJ Thomas Cunningham; Fiscal Year: 2013..in NMDA receptor function contribute to changes in the osmotic and non-osmotic regulation of vasopressin neurons in rats with experimental induced hepatic cirrhosis...
- Patient-Derived Stem Cells for Phosphoproteomic Profiling NeuropsychopathologyDieter A Wolf; Fiscal Year: 2011..Pardo, 2003 #162}, decreases CREB phosphorylation &activity of CaM kinase IV {Tardito, 2007 #163} in rat hippocampal neurons. Lithium &valproate may reduce phosphorylation of rat GluR1 {Du, 2008 #164}...
- Chromatin Modifications and Vulnerability to Glutamate ToxicityALEXEI D KONDRATYEV; Fiscal Year: 2010..receptors will result in increased DSB repair;this hypothesis we will tested by measuring DSB repair activity in rat cortical neuronal cultures;2) Impairment of H2AX phosphorylation will result in increased glutamate toxicity due to ..
- Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and CalcineurinWilliam A Sather; Fiscal Year: 2010..These fluorescent fusion constructs will be transfected into HEK293 cells or cultured rat hippocampal neurons...
- Phosphorylation as a Determinant of BK Channel Expression and LocalizationJames S Trimmer; Fiscal Year: 2010..inroads in defining the in vivo phosphorylation sites on the primary or BK1 subunit of BK channels purified from rat brain...
- Structural consequences of TSC gene mutations in brainPeter B Crino; Fiscal Year: 2012..in TSC brains that contribute to neurocognitive deficits and in vitro evidence suggests that reduction of Tsc1 in rat neurons leads to altered dendritic structure...
- TAMMY ANGALINE BUTTERICK; Fiscal Year: 2016..2) Test in vitro whether OxA-induced activation of HIF-1[unreadable] mediates intracellular metabolic changes in rat rLH sections...
- Eric J Delpire; Fiscal Year: 2014..g. WNKs and PKCs) that act upstream of SPAK and OSR1 in a rat primary afferent neuronal cell line...
- CALCIUM WAVES IN PYRAMIDAL NEURONSWilliam Ross; Fiscal Year: 2009..from stores mediated by IP3 in pyramidal cells in slices from the CA1 region of the hippocampus in Sprague Dawley rats. The first set of experiments will examine the properties of newly discovered spontaneous elementary events ("puffs"..
- MiR-15/107 microRNAs are important genetic regulators in Alzheimer diseasePeter T Nelson; Fiscal Year: 2012..We thus propose novel experiments in human brain and in primary rat brain-derived cultured cells...
- Sulie L Chang; Fiscal Year: 2014..also demonstrated that there is elevated dopamine D1 receptor (D1R) expression in the prefrontal cortex of HIV-1Tg rats, and that these animals have greater METH-induced behavioral sensitization, as assessed by stereotypical head ..
- ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITYDIPAK SARKAR; Fiscal Year: 2009..initiate and promote ethanol-induced apoptotic death of beta-endorphin neurons in the hypothalamus of newborn rats. Furthermore, we will evaluate whether ethanol induces reactive oxygen species generation and inflammatory response ..
- DIPAK KUMAR SARKAR; Fiscal Year: 2016..initiate and promote ethanol-induced apoptotic death of beta-endorphin neurons in the hypothalamus of newborn rats. Furthermore, we will evaluate whether ethanol induces reactive oxygen species generation and inflammatory response ..
- Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated CardioprotectiDONNA HOPE KORZICK; Fiscal Year: 2012..following specific aims will be tested: 1) determine which ER subtype(s) reduce IT in aged, gonadectomized female rats, 2) determine the molecular mechanism(s) by which ERs alter ROS (ONOO- and O-2) through eNOS uncoupling, post-..
- SAMY LEWIZ HABIB; Fiscal Year: 2016..Eker rats harboring mutations in TSC2 develop spontaneous renal tumors at a very high incidence...
- Neuroprotective role of RAB3B in rodent models of Parkinson's diseaseChee Yeun Chung; Fiscal Year: 2010..to study the monomeric GTPase protein RAB3B that is highly enriched in VTA (A10) compared to SN (A9) both in rat and human midbrain...
- NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITYRaymond F Novak; Fiscal Year: 2010..mechanistic molecular approaches, to identify the mechanism(s) which regulate CYP2E1 expression in primary cultured rat and human hepatocytes, and animals in vivo...
- Carbohydrate Regulation of Hepatic Gene ExpressionKosaku Uyeda; Fiscal Year: 2010..A transcription factor, purified from rat liver, with specificity for carbohydrate responsive elements (ChRE) found in the promoters of multiple genes ..
- Deregulated lipid metabolism in strokeRobert J Dempsey; Fiscal Year: 2013..accumulation, and (c) attenuated Rb phosphorylation after transient middle cerebral artery occlusion (tMCAO) in rat. Our studies strongly support SMS inhibition by D609 leading to cell cycle arrest...
- KCNQ Channels and Vasoconstrictor Signal TransductionKenneth L Byron; Fiscal Year: 2013..and blockers on mesenteric artery blood flow and systemic blood pressure measured acutely in anesthetized rats or in chronically instrumented conscious rats...
- Alicia A McDonough; Fiscal Year: 2016..The aims will be examined in rats treated acutely or chronically with agonists and inhibitors of RAS, NADPH oxidase, RSNA and altered salt diets...
- Masakazu Shiota; Fiscal Year: 2016DESCRIPTION (provided by applicant): Zucker diabetic fatty (ZDF) rats, an animal model of human type 2 diabetes associated with obesity, have a blunted response to hyperglycemia with a failure to suppress net hepatic glucose production ..
- PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTINEDUARDO NILLNI; Fiscal Year: 2009..Therefore: Aim #2. We will test the responsiveness of TRH neurons to NPY in lean versus DIO rats. Aim #3. We will test the hypothesis that NPY down regulates the prohormone convertases 1 and 2 (PC1/2). Aim #4...
- Benjamin K Canales; Fiscal Year: 2014..Currently, the mechanisms behind these adverse renal events are unknown. Preliminary data from an obese rat model of RYGB surgery indicates that gastric bypass causes more glomerular injury, interstitial macrophage ..
- Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral painMARTIN R WATTS; Fiscal Year: 2013..with increased TRPV4 expression and phosphorylation in primary visceral afferents and (2) 12-ARs inhibit VH in rats with TNBS-induced colon inflammation partly by modulating TRPV4 phosphorylation....
- Deanna S Smith; Fiscal Year: 2016..discovery of an important role for Lis1 and Nudel in regulating dynein-dependent axonal transport in cultured adult rat sensory neurons has led to the hypothesis that perturbing this regulatory network will cause neuronal dysfunction ..
- Neuronal Expression of Hemoglobin in Multiple Sclerosis CortexJennifer McDonough; Fiscal Year: 2013..We have also found hemoglobin expression in primary cultures of neurons isolated from rat brain...
- PROSPER N'GOUEMO; Fiscal Year: 2015..The objective of this application is to investigate AWS etiology in rats and mice by determining the role of LTCCs in the mechanisms underlying IC neuronal hyperexcitability in response to ..
- Bioartificial Brain Slices for Drug ScreeningERIC STEPHEN GUIRE; Fiscal Year: 2013..Acute brain slices, prepared from rats or mice, are currently the 'gold standard'preparation for characterizing neural tissue responses to drugs,..
- Michael E Hasselmo; Fiscal Year: 2016..on the coding of space by grid cells, head direction cells and conjunctive grid-by-head-direction cells in the rat medial entorhinal cortex...
- Thomas J McCown; Fiscal Year: 2016..The libraries will be injected intravenously into rats with documented chronic, spontaneous seizure activity...
- James J Knierim; Fiscal Year: 2016..optogenetics, and juxtacellular labeling will be used to (a) record the spatial firing properties of DG neurons as rats explore different environments and (b) assign these properties to the specific cell types...
- Jason Dwyer; Fiscal Year: 2014..to deliver a mutant, constitutively active version of p70 S6 kinase to the prefrontal cortex or hippocampus of rats before exposure to chronic stress...
- Irving H Zucker; Fiscal Year: 2016..that enhanced voltage-gated sodium channel (Nav) activity in muscle afferent neurons (DRG's) of CHF rats contributes to the enhanced afferent neuronal excitability and the EPR...
- ASHLEY LINDA KEES; Fiscal Year: 2014..To do this, the firing activity of individual neurons will be recorded while a rat is exploring an environment in virtual reality...
- HEIDI GRABENSTATTER; Fiscal Year: 2015..studies demonstrate significant decreases in connexin phosphorylation 48 h after SE and in chronically epileptic rats 30 d after SE...
- MAGNETIZATION TRANSFER MRS IN METHAMPHETAMINE USERS RESUBMISSIONYoung Hoon Sung; Fiscal Year: 2013..mitochondrial respiratory chain, and a single dose of METH causes mitochondrial dysfunction and oxidative stress in rat brain...
- Zhiyi Zuo; Fiscal Year: 2015..study showed that isoflurane at a clinically relevant concentration impaired the learning and memory of old rats. This detrimental effect on old rats was attenuated by intravenous lidocaine, a local anesthetic that has anti-..
- Yasmin L Hurd; Fiscal Year: 2016..Similar gene expression patterns were detected in the ventral striatum of rats exposed to ?-tetrahydrocannabinol (THC), the psychoactive component of cannabis, prenatally as well as during ..
- Anna Moszczynska; Fiscal Year: 2016..We hypothesize that increasing their functions will provide neuroprotection in rats chronically and acutely exposed to METH...
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text:
From the National Co-Ordinator of Diocesan Vocations Fr Paddy Rushe:
Fr. Paddy Rushe, National Coordinator of Diocesan Vocation Directors, said that these figures represented the highest intake of new seminarians since 1999, and were almost double the number that entered in 2003. "I want to acknowledge the hard work of vocation directors around the country who have spent time, in many cases well over a year, guiding and directing these men and preparing them for this step in their lives. Despite ongoing challenges to the Gospel values in the modern world it is encouraging to see evidence that God continues to inspire people to answer His call of service in the priesthood," he said.
Most of the new seminarians will study at St Patrick's College, Maynooth with others studying in Belfast, Rome and Spain. Welcoming the new candidates, their families and friends to Maynooth, the President of the College, Monsignor Hugh Connolly, said: "It is truly wonderful to witness the generosity of spirit of our new seminarians as, at this time, the Church in Ireland has completed a 'Year of Vocation' and we begin, together with all the faithful throughout the world, the 'Year for Priests'."
The new students range in age from those who have just completed their Leaving Certificate to those in their thirties and forties who are coming from a wide range of employment backgrounds.
Bishop Donal McKeown, chairperson of the Vocations Commission of the Irish Episcopal Conference, also welcomed the news saying that it was an encouragement to all those in parish communities and other organisations associated with the promotion of vocations, who continue to pray for and promote vocations in many ways. "Priests don't just appear out of mid-air," he said, "they come from families and communities; they are sons, brothers and uncles; work colleagues and friends; part of a Christian community."
A breakdown, by diocese, of the 38 first year seminarians for 2009 is as follows:
Ardagh & Clonmacnois 2; Armagh 3; Cashel & Emly 1; Clogher 1; Cloyne 2; Cork & Ross 1; Down & Connor 5; Dublin 5; Galway 2; Kildare & Leighlin 2; Killaloe 2; Kilmore 3; Meath 4; Ossory 1; Raphoe 2; Tuam 1 and Waterford & Lismore 1.
36 new seminarians will begin studies immediately, with another 2 commencing during the first term. 30 new seminarians began studies for Irish dioceses in 2008, 31 in 2007 and 30 in 2006, 27 in 2005, 28 in 2004, 19 in 2003.
The students will be spread over St. Patrick's College, Maynooth; St. Malachy's College, Belfast, The Pontifical Beda College, Rome; and The Royal English College, Valladolid, Spain;
The St Patrick's College Maynooth is the National Seminary for Ireland and has been forming men for the priesthood since 1795, see the college website here.
The website for the Diocesan Vocations Directors of Ireland is available here.


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Home The Furniture of Poul Kjaerholm : Catalogue Raisonné
The Furniture of Poul Kjaerholm : Catalogue Raisonné
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The Furniture of Poul Kjaerholm: Catalogue Raisonné
223 pages
b&w photos
Hard cover with dust jacket
23 x 23 cm
0,991 kg
This volume includes 70 entries that document, analyze and describe all of Kjærholm's realized designs. The entries include furniture dimensions and information about materials, as well as a wealth of drawings and vintage photographs. The book features the renowned Modernist photographer Keld Helmer-Petersen's iconic photographs of Kjaerholm's work. Helmer-Petersen was Kjærholm's creative partner for three decades and documented his furniture and exhibitions over this period. Sheridan's biographical essay traces and discusses the development of Kjærholm's formal vision over the course of his career. Supplementary information includes a timeline of production dates, manufacturer information, notes on materials and maintenance and production stamps.
The book was compiled with the assistance of the Kjærholm family and includes a foreword by Hanne Kjærholm. It was designed by Takaaki Matsumoto, one of the most respected designers of art books in the world. Printed entirely in black-and-white duotone, the many archival photographs in the book are reproduced in the finest quality. Destined to become a model for the field of design, The Furniture of Poul Kjærholm is an instant classic and an essential reference for readers interested in furniture, interior design and the history of Modern architecture and design.


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Executives close to CompuServe tell Advertising Age that the online service and its parent, H&R Block, in recent weeks have made overtures to Sears, which is known to be interested in shedding its Prodigy holdings. No formal offer is on the table, but analysts value the stake at $500 million.
Just how CompuServe and H&R Block would work with Prodigy's other owner, IBM Corp., isn't clear. IBM is said to have held discussions with Sears earlier this year about taking over management of Prodigy. Observers say IBM doesn't want to get out of the online business but that it's frustrated by Prodigy's performance.
An IBM spokesman wouldn't confirm or deny CompuServe-Sears talks, nor would he discuss IBM's plans for Prodigy. As for Sears, "we don't comment on rumors or speculation," a spokeswoman said.
CompuServe plans to roll out a new, consumer-friendly online service early next year, code-named "Wow." Executives close to the company speculated that CompuServe would like to meld Prodigy, which has a strong reputation as a family-oriented service, with Wow. CompuServe's existing online service is technology-oriented and has a strong appeal in the business community.
"I would absolutely think that inside the confines of CompuServe ..... anything's on the table now because they don't want to give up their lead," said Emily Green, senior analyst at Forrester Research, Cambridge, Mass. She said that at a meeting earlier this summer, Bob Massey, CompuServe's new president-CEO, "did not discount the possibility" of a deal with Prodigy.
Mr. Massey declined to comment to Ad Age on whether a bid is being considered for Sears' stake. But he added: "Everyone knows that Sears is interested in bailing out [of Prodigy], and they're interested in finding a suitor ..... I think each of the Big 3 [online] companies would have an interest in working with the other if the price was right."
H&R Block President-CEO Richard Brown couldn't be reached. But Ozzie Wenich, VP-finance, said: "I know of no such initiative."
Sears and IBM have invested more than $1 billion in Prodigy since its founding in the early 1980s, and the online company only recently has begun to show a profit, albeit a small one.
"It is not clear, frankly, that we bring anything to it," Sears Chairman-CEO Arthur Martinez told Reuters earlier this year.
Sears' share of Prodigy posted an after-tax loss of $900,000 for the first six months of 1995, an improvement from the previous year's loss of $3.8 million, according to figures obtained by Crain's Chicago Business.
The online industry has already seen one major consolidation this year as MCI Communications Corp. merged its fledgling Internet operation with News Corp.'s struggling Delphi service.
Prodigy's strongest asset is its subscribers, but that value dwindles each day as its competition's lead grows. Prodigy has 2.2 million subscribers, trailing No. 2 CompuServe's 3 million and fast-growing No. 1 America Online's 3.5 million.
New Prodigy President-CEO Ed Bennett has begun an aggressive marketing campaign to change the online service's image, but some say the drive may be coming too late.
"What Ed is trying to do is to move the Prodigy brand into the mainstream, and we all know how hard it is to move brands," said Scott Kurnit, president of MCI/News Corp. Online Ventures and Prodigy's former marketing chief.
Analysts say a deal between CompuServe and Prodigy would be difficult to complete, despite the apparent synergies between Prodigy's subscribership and CompuServe's planned Wow service.
"If Sears were smart, they'd spin their share off to the public to get what it's worth," said Ab-hishek Gami, an analyst at Duff & Phelps Equity Research, Chicago. A CompuServe investment in Prodigy "would require a complete overhaul of the look and feel and software and underlying technology of the service."
Contributing to this story: Kim Cleland and Bradley Johnson and Crain's Chicago Business Associate Editor Mark Veverka.


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In a land ruled by prophecy and the whims of gods, a young man finds himself at the heart of a war he barely understands, wielding powers he may never be able to control.
Isak is a white-eye, born bigger, more charismatic, and more powerful than normal men. But with that power comes an unpredictable temper and an inner rage he cannot always hide. Brought up as a wagon-brat, feared and despised by those around him, he dreams of a place in the army and a chance to live his own life. But when the call comes, it isn't to be a soldier, for the gods have other plans for the intemperate teenager: Isak has been chosen as heir-elect to the brooding Lord Bahl, the white-eye Lord of the Farlan.
The white-eyes were created by the gods to bring order out of chaos, for their magnetic charm and formidable strength makes them natural leaders of men. Lord Bahl is typical of the breed: he inspires and oppresses those around him in equal measure. He can be brusque and impatient, a difficult mentor for a boy every bit as volatile as he is.
But now is the time for the forging of empires. With mounting envy and malice, the men who would themselves be kings watch Isak, chosen by gods as flawed as the humans who serve them, as he is shaped and molded to fulfill the prophecies that circle him like scavenger birds. Divine fury and mortal strife is about to spill over and paint the world with blood.
The Stormcaller is the first book in a powerful new series that combines inspired world-building, epoch-shattering battles, and high emotion to dazzling effect.


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Prince Charming & his preparation to find a Valentine.
Daisy closed her eyes and heard lots of noises and a sheep. Wait. Did she hear that correctly? Was that the sound of a sheep? No. She must have misheard this.
Hi TJ, nice story & pictures! Will you do more little comic strip-type stories like this?ReplyDelete
TJ. I apologize for my late reply. Thanks for answering my questions. I did have a good look around your website, somehow I missed that piece of information. Must admit I instantly fell in love with the illustrated birds in your previous entry. I hope you're having a nice weekend. :)
- Solelyshe
Aww I love that Daisy is so little :)
Haha! That he stopped listening because he was striking a pose! Him riding a sheep reminded of that time I rode a goat as a child. Which is a strange but true fact!
Loved the tale, I think it is a great way to introduce more characters and let us get to know them better.
Ah ha ha! I love it! We'll see if my man comes riding in one a white sheep tonight. Somehow, I kind of doubt it. :)
Happy Valentine's Day, my lovely friend! XO
@ Arjan: Heey Arjan! Thanks so much!! Yes, you can expect more little stories like this! Me and Claire will do this every once in a while. So stay tuned. Thanks so much for stopping by! Groetjes!
@ Solelyshe: Ciao! Don't worry at all and you're welcome :D. Ooh I hope you will like the final result when you see it too! Have a lovely week ahead as well! Xx
@ Claire: Hahah! You know I love striking a pose hehe. Can you recall my fave one? It's the one you don't like haha. From a certain musician...
I love Daisy! She was pretty easy to draw in the end. Ooh you rode a goat as a child? Wait. This sounds familiar. I think you've told me this? I must ponder a bit more about it. I agree, this is definitely a great way to practice the same character and come up with short stories. Now...bring on challenge number 2! Hehe
@ Tricia: Ciaoo Tricia! Haha. Glad you like it :D. Hmm it must be a HUGE sheep then. I don't think normal people could ride a sheep, unless they are little. Like Claire did hehe. For your man a horse would be better ;). Happy Valentine's Day to you as well! Xoxo!
@Ollie: Haha! Thank you! Yeah, it's an interesting prince! But then again the conversation I had with Tricia was interesting too haha. So it makes perfect sense. Happy Valentine's Day as well!
This is really great! Good job, TJ! Happy Valentines day!ReplyDelete
TJ, you are gifted in so many ways!! Happy Valentine's Day!ReplyDelete
Ihihihi i love this little story!!! I also want my prince.charming to come on a sheep ahahah :pReplyDelete
Cute and funny. Great job!
And thanks for contributing a picture to our site. Hope you get some traffic.
Happy V Day! Have fun.
Captivating and brilliantly comedic. :)ReplyDelete
TJ-I see it all before me in my mind's eye, in annotated gold letters: "Tales Of The Kooky Prince."
A modern Don Quixote story, with Daisy playing the Sancho Panza character, his sober and down-to earth sidekick.
Prince Charm has a lot to learn, doesn't he?ReplyDelete
Sheeps are awesome! Lovely post buddy!ReplyDelete
What a sweet, silly tale! And sheep are SO SEXY. I think the prince is on to something. ;)ReplyDelete
I hope the Prince and DAisy are just friends. With the size difference there might be some compatibility issues.ReplyDelete
Woolly or won't he?ReplyDelete
awwww this is TOOO CUTE!!! ^__^
Wow, totally love this, so cute I had to tweet about it! So glad you and Clare put up your links on blog catalog so I could find your blogs!
I will start following!
Thanks for the post!
Lauren K
Aww this was cute. The pictures made the story.ReplyDelete
Nice story TJ, and the pictures went perfectly with it. :)ReplyDelete
Ha! That was really sweet. Hope you had a good Valentine's Day. :)ReplyDelete
@ Leadrocket: Thanks so much!! Really glad you liked it! Take care!
@ Judie: You're really sweet Judie! Thanks so much! Xx
@ Ancilla: Yo kiks! You know I can arrange for your prince to ride a sheep hehehe. Be careful what you wish for...*evil laugh*
@ One of the Guys: Hey Sae! Thank you and you're most welcome for the illustration! Glad I could help ^_^. Ciao!
@Timethief: That's such a nice thing to say TT! Thank you!
@ NP: Ooooh now that would be awesome NP! Haha. Such a great visual and the gold lettering fits it perfectly ^_^. I'll write it down! Thanks for strolling by NP!
@ Deray: Ciao Diana! Haha yes he has quite a lot to learn hehe. Thank for stopping by! Xx
@ LubranoMusic2: Yo Frenks! You know you're a sheep don't you??? Hehehe. Thanks Buddy!
@ Janene: Ciaoo Janene! Haha sexy sheep! For some reason I imagine the sheep with sunglasses striking a pose hehe. We need to keep a close eye on the prince! Not sure what he has in mind now! Thanks for stopping by :D
@ Doug S.: Hi there & Welcome! Haha! Yeah they are just friends ;)
@ Sci-Fi Gene: Hey there & Welcome as well! Haha Woolly? Not so sure if I get what you're trying to say…^_^
@ Sympathy for the Devil: THANK YOU pretty Mita!!! Xoxoxoxo
@ Lauren K: Hey Lauren! Welcome & Thanks so much for your lovely comment! Glad you loved the story :D. I haven't browsed your blog just yet, will do this asap! Take care Xx
@ EmDottie: Hi there & thanks so much for your comment :D
@ Daniel W.: Hey Daniel! Thanks so much :D
@ Lana G.: Heeey Lana! Thank you for strolling by & your comment! It was a nice day ^_^. Hope you had a lovely day as well! Xx
No man named Charming should scream like a girl... ever. Just sayin'.ReplyDelete
@ Bill: Hahah! Were you...shocked? Hehe. Prince Charming is quite the character. He does strange things...ReplyDelete
Aw.......what a fun one to re-read! :) I wanna hear all about your trip - I'm so envious that you and Claire got to meet up, that's awesome!!ReplyDelete
Haha. He just popped up in my folders. I started to clean them, but stopped as it took a bit too much time!
I will email you and I'll write a post soon. Need to get a few things out of the way first! I'm sure we will meet as well Tricia!! Fingers crossed it's sooner than later!!


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6" 3M Safety-Walk Medium Resilient Tread 310 Per Foot
For barefoot or shoe-traffic areas. Non-mineral, medium-textured, slip resistant vinyl surface. Resilient surface and durable adhesive provide long-lasting performance. Applications include locker rooms, around hot tubs and pools, boats, personal watercraft, water skis, exercise equipment, and conveyers.
All in stock parts and accessory orders will ship within 1-2 business days.
Next Day Air/Second Day Air/Select in stock parts orders placed after 12:00pm EST will ship the next business day.
Most cable orders placed by 12:00pm EST will ship within 24 hr. Monday-Friday
Pad orders are currently shipping in 10-12 business days.


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Prince Charlie Exclusive Tartan Trews Outfit
The Prince Charlie Exclusive Tartan Outfit provides a traditional look with a twist. As it is stylish, formal look it is a perfect choice for weddings. But because of it's classic nature it can also be worn at anytime for any function
This outfit consists of:
- Charcoal grey Holyrood Jacket & Waistcoat
- Made to Measure, Bespoke Trews in ExclusiveTartan.
- Ghillie brogue shoes
All additional accessories to be purchased separately


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If you are curious, the Absolute Christmas contains everything from Wham's Last Christmas, Abba's Happy New Year and Harry Belefonte.
But some classics are this one here:
Nu är det jul igen! The lyrics are: Now it is Christmas again, Now it is Christmas again, and it will go on until Easter, but that isn't true, that isn't true because in the middle is Lent.
It works better in Swedish
All good Swedish holidays include the drinking of the snaaps. But before there is the drinking of the snaaps there must be singing. At Christmas you sing this one:
Hej tomtegubbar
The translation is: Hello Santas bang your glasses and let us merry be! Hey Santas bang your glasses and let us merry be! A little while, we will live here, with lots of effort and trouble. Hello Santas bang your glasses and let us merry be!
And if my first paragraph just left you nostalgic for Wham.... there is always this: