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confidentiality and anti-retaliation provisions
Whistleblowers: The AMF will not offer any reward
July 6, 2016 Occasional Contributors Accounting Systems and Controls, Board of Directors, Process and Responsibilities, Budgeting and Auditing, Business and Legal Issues, Corporate Administration, Corporate Administration and Legal Matters, Corporate Governance, Environmental Issues, Finance and Accounting, Financial Management, Fraud and Corruption, IT, Privacy and Security, Leadership and Management, Network, Systems and Data Security, Not for Profit, Payroll and Personnel Management, Privacy Compliance and Management, Records Management and Retention, Volunteers and Employee Relations
On February 18, 2016, after a thorough and rigorous analysis which included closely monitoring the rewards-based whistleblower programs offered by the U.S. and Ontario, the Autorité des marchés financiers (the AMF) announced that it does not intend to offer financial rewards to whistleblowers. Instead, the AMF wishes to promote a whistleblower program that builds on existing measures.
AMF Whistleblower Program, anti-reprisal measures and anonymity for whistleblowers, Autorité des marchés financiers, confidentiality, confidentiality and anti-retaliation provisions, financial rewards to whistleblowers, Ontario Securities Commission, Osler, quality whistleblowing, Whistleblower Information Form, whistleblower programs, whistleblowing
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I've never called out an alert for the Pennsylvania Liquor Control Board, but I noticed a dramatic offering that needs to be shared. I've mentioned before that the state of Pennsylvania is one of the few places that still has Yamazaki 12 for sale at a non-auction price point (yes, dozens of bottle still remain on shelves in and around Pittsburgh), but there is another now that needs mention.
Laphroaig 18 year old, marked down to $USD 63.99. Seriously.
For those of us in Ontario, after the currency exchange the price of this bottle is comparable to what we would pay for the Laphroaig 10 year old at LCBO. I cannot say enough about how exquisite this expression from Laphroaig is. All the smoky goodness of the 10 year, but mellowed, rounded and rich after its extended rest. Back when LCBO was carrying this expression, it was most recently priced in the $CAD 175 range, and a quick search shows a similar price point online and at retail in the US and UK. For this price it's a steal, a truly can't-pass-up kind of deal if you happen to find yourself in PA.
According to the PLCB website there's about 110 bottles scattered over the state. With this pricing I can only assume that this expression is on clearance. So, like the Yamazaki 12, don't expect any more to be gracing the PLCB shelves in the future. Get it while you can.
Happy foraging!

subset: commoncrawl


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Once a man came to his wife with a paper on which a line was sketched. He asked her to make that line small without cutting or erasing it. The wife pondered for a moment, then drew one more line there, which was longer than the previous one. The previous line automatically became small.
Our problems are exactly like this. If we encounter a major problem in life, the other problem, which earlier seemed a big one, diminishes itself.
Problems, in some way, are like real test of life. They can make you stronger. They can make you hone your skills unknowingly. Sometimes, your luck may shine and an opportunity may come to you in the disguise of a problem and can be beneficial for your personal growth. Many inventions are derived due to problems.
No doubt, some problems affect one's life badly. Nobody likes problem in their life. But they are meant to accompany you, throughout your life. You can't run away from your problems. The more you try to run away from them, the more they chase you. So, face it! Take it as a challenge and fight back. Share your problems with your friends and family. Ask for help, if needed. You may get an intelligent advice. There is a solution to every problem. Find out. Keeping correct and positive attitude in life is the best way to tackle your problems.


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The Best of the Music & Art Scene In New York From A to G. Daily!
Posted by The G on March 20, 2012 under Street Art | Comments are off for this article
Photo by G.
Come Queer - Stay Rebel
I'm not whatever you think I am.
I completely understand!
Tags: 2012, Come Queer Stay Rebel, New York, Photo, Street Art
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Defending life from conception to natural death
SPUC supports parents and medical professionals in helping to protect children, before and after birth
SPUC has a team of highly trained speakers to visit your school free of charge.
Read about our founders, the aims spelt out in our constitution and some of the campaigns we've been involved in
We stand shoulder to shoulder with the African pro-life movement as part of the global witness to life
SPUC has been defending unborn children for nearly 50 years, both in the UK and internationally
We want you to be a part of our life-saving work: get in touch to find out how you can help end abortion
Be the first to know about breaking pro-life news stories
Read our latest blogposts from famous pro-lifers, local activists, SPUC staff, guest stars and more
Get the latest edition of our newsletter
SPUC's charities bulletin is a guide to where many well-known charities stand on abortion and other pro-life issues
The universal right to life of every human being is the foundation on which all other rights rely
Pro-life feminists represent a growing number of women who believe passionately in women's empowerment and the universal right to life
Want to find out more about abortion? Wondering about the hard cases? Our FAQ page is here to answer all your questions
6 September 2009
International pro-life leader gives SPUC grounds for hope Derby, Sunday 6 September - Legalised abortion contains the seeds of its own destruction, according to the president of the International Right to Life Federation.
Dr Jack Willke head of the Life Issues Institute, Ohio, gave this optimistic message to the annual national conference of the Society for the Protection of Unborn Children (SPUC) this weekend.
Dr Willke said that women who had had abortions were now mothers and were advising their daughters not to make the same mistake that they had made.
Young women were noticing that other girls who had abortions were badly affected by the experience.
Arguments which had been initially deployed to legalise abortion were no longer effective.
Nowadays, when abortion supporters said that unborn children were not babies, many people were appalled and thought of images from prenatal scans.
There was no relationship between how mothers felt towards their unborn children and how they treated them after birth, which undermined the argument that unwanted babies should be aborted. Dr Willke said that the number of illegal abortions had been wildly exaggerated by abortion supporters.
There was no evidence that the tightening of Poland's abortion law had led to illegal abortion.
Maternal mortality was a bigger problem in countries with a high abortion rate.
The overpopulation argument had also been undermined by the way in which many countries with legal abortion had birth rates which were below replacement levels.
The issue was no longer just a Catholic one, with Muslims and Evangelicals also opposing abortion.
Dr Willke pointed out that, in America, the number of pro-life pregnancy help centres had grown immensely.
He had found that few women wanted to speak out positively about their abortion experience.
Women were actually increasingly prepared to say why they regretted their abortions.
To the original pro-life argument that abortion kills babies could be added the argument that abortion hurts women.
It also hurt men, who increasingly sought support after abortion.
Pro-life people were having more children than abortion supporters which was changing the nature of public opinion.
American pro-life activists were fighting abortion by getting states to restrict it through regulation.
While Dr Willke did not think he would live to see a change in abortion law, he thought his children would.
He told the conference: "We must keep doing what we're doing. It's slow but we shall win in the end." One could not lose the argument when one advanced the case that abortion killed babies.


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It is an unfortunate fact of life that just when everything seems to be running along smoothly, that is when disaster chooses to rear its ugly head. The same is certainly true in business. You may think that everything is going perfectly according to the plan until you are struck by an event that suddenly blows everything off course. It may be that you suddenly lose some major clients, you suffer a lawsuit or your company reputation is damaged. Whatever the case, here are a few of the top ways that you can defend your business from disaster.
Undertake a Full Risk Assessment
Before you can hope to defend your business from disaster, you need to be clear about where the risks are coming from in the first place. Only then can you evaluate how prepared your business is to deal with each one of these situations. There are a number of questions that you can ask yourself; how often do you check in with your insurance and legal team?; are all your files properly protected?; have your employees been properly briefed to deal with negative situations? You should try to prepare for as many potential disasters as you can to put yourself in the strongest possible position.
Review Your Insurance Coverage
We have already talked about it briefly, but you need to make sure that you review your insurance coverage to ensure that you are fully covered in all eventualities. There would be nothing worse than thinking you are fully protected only to find out that you don't have the level of coverage you need when you come to make a claim.
Back up Your Data
One of the biggest threats that businesses are in danger of these days is being hit by a cyberattack. Listening to this ransomware expert on nbc can really put things into perspective about what a problem this is for businesses all around the world. Using cloud-based technology solutions can put you one step ahead of the game as you are protecting your data while also giving yourself the opportunity to access it from anywhere.
Create a Contingency Plan
Having a clear and effective contingency plan in place is essential in order to evaluate how prepared your business is for disaster striking. You need to identify which areas of your business are absolutely essential for its continued running and which can be sacrificed. You should run through this plan on a regular basis with your key members of staff. Remember, it is much better to be overprepared than underprepared.
Come Up with a Communications Strategy
Things can quickly become chaotic in your business unless you have a clear strategy of how you will communicate the issue both internally with your staff and externally to clients. This is where it can pay off to offer a bit of honesty about the issues you have faced and how quickly you will be able to get operations running smoothly again.
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Tech News You Can (Actually) Use
Why Being A Flexible Investor Matters


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Makeup Tips and Tricks for Glasses
Before I started wearing contacts I would have to wear my glasses religiously...I can't barely see anything yall! However, the one thing that has never stopped me from wearing my glasses was my makeup. I love making a statement with my eyes! I would throw on smokey looks, colorful looks it didn't matter I loved it and I knew how to rock it! Indeed I did, but, I know that for others it can be a little tricky wearing makeup with glasses, especially if you are a beginner.
I wanted to help you with some tips and tricks I've learned and have research that can help you make your peepers(your eyes) pop behind your frames!
Simple Does the Eyes Good
I love a good cat eye! Apply tons of mascara to open up the eyes because, sometimes with glasses our eyes tend to appear smaller. Try a waterproof mascara for a smudge-free look that is sure to make your eyes stand out! A smokey eye can make your eyes look darker, save this for when you are wearing contacts!
Brighten and Conceal
Brighten up your peepers with a concealer that highlighters and covers. Use a yellow or orange correctors to cancel out any purple or blues underneath your eyes and anywhere there is bruising.
Make it Pop!
Instead of using color on your eyes why not try your lips! There are so many lip colors out in many different finishes such as matte, semi matte, semi glossy to glossy, lip jumbo pencils, and lacquers! You can pair it with a cat eye or with just mascara for a clean effect!
Brow Drama
Most of the time the frames will not cover the eyebrows so we need to make sure your brows are neat and clean. Use a tweezer to clean up any unwanted hair and then use your favorite brow kit to define! Make sure that the parts of your eyebrows on the outside of your frames are even with your glasses. Check out this my tutorial on How to Get Clean Natural Brows!
Go Bold with Strong Frames
You can get away with wearing strong makeup looks like smokey eyes with strong frames. A bold eyeliner look with a dark eyeshadow close to your bottom lashes gives your eyes and edgy look. Make sure the bottom lash area is clean from any fall out afterward!
The thicker the frame the bolder the makeup look!
Keep it simple with frames that are smaller. You don't want your eye makeup to over power these frames for fear of looking to dark in the eyes. REMEMBER: Thin liners for thin glasses!
Don't let your eye makeup compete with your glasses
Just like in #5 or #6 we don't need competition between the two just a basic understanding. If you want to wear the same color eyeshadow as your glasses then make sure that the color is lighter than the color of your frames. Add a darker color in the crease for contrast! A lighter color stands out instead of drawing your eyes inward for a dark look.
Sometimes dark rimmed or thick frames cast a dark shadow on your eyes. To brighten up your eyes and your face add a highlighter on the inner corner of your eyes and then highlight your cheekbones.
Blushing Babe
Get a nice flush with a blush that compliments your natural skin tone.
Fair: Light Pinks, corals, and peaches
Medium: Warm Pinks, deep peaches, and mauve
Dark: Deep Fuchsia, warm browns, and tangerines
Play up your other features
Don't be afraid to do something different with your hair. Do a nice blowout with waves if you have long flowy hair, add a top bun if you are feeling lazy, or pull your hair behind your ears for a sleek style. My all time favorite way to stand out is adding a fedora, headbands, or the parisian beret! Wearing glasses make certain hairstyles and hats stand out, so, switch up your style every now and again.


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Humanitarian House International, Inc.1 is a Colorado-based 501(c)(3) non-profit organization focused on developing and deploying housing solutions for families and communities attempting to survive natural disasters, war, and other life-affecting events.
Humanitarian House International (HHI) was started by Stuart Ohlson, an architect of sky-scraping, award-winning residential buildings around the world. Mr. Ohlson was a founder of Ohlson Lavoie Collaborative (OLC), a highly-respected international architecture firm headquartered in Denver, Colorado, with additional offices in Orlando, Tokyo, and Cairo.
Following his retirement, Mr. Ohlson turned passionate and trained eyes on the plight of earthquake victims in Haiti.
Our vision is to "save the world, one house at a time."
Our mission is to build the finest emergency housing available worldwide, and to supply add-ons to transform emergency housing into unique, permanent homes. By doing so, we hope to enable people to move from hopelessness to hope; from subsistence to productivity.
We are a group of experienced architects, builders, and managers with one goal: to make the world better for the unfortunate who are living in distressed conditions and who need housing that is not only emergency housing but also housing that will last for years.
Humanitarian House International's management team includes seasoned veterans with diverse and deep credentials:
1Humanitarian House International, Inc. is a 501(c)(3) non-profit organization. Your donation is tax deductible to the extent allowed by law.


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Last updated: April 14, 2015
Parks as Classrooms
Curriculum Materials
These lessons utilize primary sources and background information to help students understand the process of resolving conflict. Students will analyze all information related to the Camp David Accords to learn how and why the U.S., Israel, and Egypt negotiated this historic peace agreement. They will analyze the agreement, understanding that every party doesn't get all they want in a compromise.All Curriculum Materials
Lesson Plan
A Pathway to Peace - Jimmy Carter and the Camp David AccordsLearn More
Field Trips
Bring your students to the Jimmy Carter National Historic Site. Find resources for planning your own trip and links to ranger programs and more.All Field Trips


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Abeba 31058
Safety shoes with breathing Air-Mesh fabric and laces.Array
Base price € 78,73
€ 78,73
Abeba 31058
Smooth leather ESD safety shoes with breathing Air-Mesh fabric and laces.
''Silver Point" lining.
With non slip sole.
With steel toe caps.
Closed shock absorbing and antistatic heel.
With reflecting stripes.
With removable insole (art no.3557)
Available in sizes 35-48.


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Pattern construction is very fun when everything goes your way. When you get unexpected difficulties, on the other hand... I had planned my construction thinking the slubs in dupion run down the fabric, but turns out they run across. Long story short, I'd done a lot of work for nothing.
When things like this happen, it's
|There's going to be a princess bodice. The shoulder dart is moved to the armscye.
I'm still pretty new to pattern construction, so to be sure everything looks like it should, I often tape together a test. The protuding shoulder part had been draped and then transferred to the paper construction. In 3D I was able to see that there was a sharp edge between those two parts, and then fixed it.
|Making the pattern for the organza bits on the hips.
Some of the people in my class took a trip out to one of the largest fabric stores in Norway. For a person whose only options for getting fabric has been a craft store selling only quilting cotton or an interior store that sometimes has curtains that can be cut up and used for other things, entering this building is like Yule and Halloween on the same day.
|I am fire, I am ... Death! ...Or maybe not.
I went relatively berserk and bought all of the pretties. There's everything from studs, to pearls to sequins. In addition to the fruits of my raid, I already had loads of stuff lying around.
|A polite reminder what the design looks like.
|Chosen fabrics, silk thread and some rhinestones.


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Motel accommodation & activities in Christchurch
Christchurch, also known as 'The Garden City', is the largest city in the South Island of New Zealand.
Since the Earthquake of 2010-2011 the city has re emerged as a fun, vibrant and constantly changing city. Spend some time in the city wandering around the Re:START Mall, a purpose built container precinct around 40 shops and cafes to explore
You can explore the city on an open top bus or by tram. Dont forget to check out the all new Cardboard Cathderal
Try rafting down the Rangitata River, horse trekking along the picturesque Banks Peninsula and much more- Christchurch is one of those holiday destinations that most visitors fall in love with, and it's so easy to see why!
Golden Chain Motels in Christchurch, New Zealand:
Adorian Motel
Excellent prices at our tidy and quiet motel in a quiet residential street close to central Christchurch. No Breakfast Available. Only 15 minutes walk or a 5 minute drive to Christchurchs city center, Cathedral Square and Cashel St mall and many other attractions. A short walk will bring you to the local supermarket, . . .
Aotea Motel
Aotea Motel is situated in the heart of Christchurch and offers a complete range of facilities and services to guests. A 15-minute walk by the river to the city centre, hospitals and casino. Christchurch International airport is just a 20 minute drive. Aotea Motel offers 10 units all with kitchen . . .
Ashford Motor Lodge
At the Ashford Motor Lodge, we endeavour to ensure that your stay in our Christchurch accommodation is both pleasurable and peaceful. Through this page, we invite you to familiarise yourself with our award winning Christchurch accommodation venue, and to take advantage of our unparalleled hospitality and comfort on your next . . .
Chardonnay Motor Lodge - Christchurch
Chardonnay Motor Lodge is set amongst spectacular grounds and gardens. Located just a short stroll from the Groynes recreational area, with walks, lake, picnic areas and playgrounds. Chardonnay Motor Lodge is 7 minutes from Christchurch airport and just 15 minutes drive to the city centre (own vehicle recommended). Close by . . .
Christchurch City Park Motel
Experience friendly Christchurch motel accommodation in the best location! We offer 25 spacious motel style units with plenty of options for the corporate traveller, couples, families and larger groups. Including studio units, one bedroom units and two bedroom units. All units are non smoking and serviced daily. Sky Guest Select in . . .
Christchurch Motel
Christchurch motel is within walking distance of two major shopping centres, and Canterbury University. We are a Qualmark 4 star rated property offering a number of double and twin studios as well as one bedroom and two bedroom units. Ideally located in Riccarton Road we are within walking distance to 2 . . .
Colombo Lodge
Colombo Lodge Christchurch is a boutique hotel that is located in the Christchurch City. The hotel is conveniently situated Colombo Street Christchurch city and is just a short walk from the Colombo Mall and South City Mall with its numerous specialty stores and supermarket. Colombo Lodge Christchurch is within easy . . .
Christchurch Motels:
Golden Chain Motels
PO Box 5341
New Zealand
(0800 804 653) - NZ only
(1 800 504 732) - within Australia
Tel: +64 3 358 0821
Fax: +64 3 358 5012
Email: firstname.lastname@example.com


text: Hey, look at the time! I've been at a bit of a do. I look like Batman, not because of the Batsuit, or heaven forbid because I was in the stir, no because I'm in a tux. Of course I'm tea-total so I'm annoyingly sober. Anyhoo, I just noticed my review of Danny Hellman's terrific Typhon anthology is on the Forbidden Planet blog, thanks to Joe's hard work (there is also a horror goody, so do drop in).


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Rating: 5/10
Label: Ripple Music 2011
Review by: Urban "Wally" Wallstrom
"The type of Rock N Roll that will make you feel nostalgic for the seventies". Huh? How can you feel "nostalgic" towards something which you never experienced in the first place??? I'll have to file this under "geezer" rock, then??? Well, Port Orchard, Washington, U.S. rockers Stone Axe were formed in direct homage to the classic heavy rock of the seventies, and mult-instrumentalist, sometime-vocalist, princicpal songwriter and recording engineer, T.Dallas Reid, wouldn't have it any other way.
The band's supposed to encompass the tones, moods and attitude, essentially perserving the sound of a by-gone era that brought some of the best heavy rock according to the band of course, yet still fusing modern elements to make the sound relevant for the future. Ehem, well, to be honest, it merely sounds like they don't know which foot to stand upon or in other words, 'we're desperately trying to lure old geezers and youngsters to buy our (schizo) CD'. The record label and the press-release, just as fookin' desperate, since they're trying to sell this as something for fans of and I quote: Led Zeppelin, Thin Lizzy, AC/DC, Free, Deep Purple, Bad Company, The Faces, Whitesnake. My oh my... I believe you're not supposed to laugh, but it's just sooo laughable. Sure, why not? let's namedrop every single band of the 70's and perhaps the buyers are stoopid enough to believe the write-up.
Okay, that's enough of hype and what about the music? Well, this is the debut album once again, now re-released in a deluxe editon CD package that includes a half hour of bonus live recordings, as well as more than 70 minutes of promotional videos and live footage that make up the bonus DVD. For your hard-earned money you get quite a lot of music and a few tunes knocked out by the band, not too shabby at all really. However, it's reeks of "desperation" and it's so "wrong" somehow. One minute you have a track inspired by AC/DC, the other it's something in the vein of Thin Lizzy, Bad Company, Stoner Rock, etc, etc. It's not a proper sound, it's like one of those after-ski bands doing their best to please every single person in/of the audience (probably all 18 of them). "There'd Be Days" is a smashing tune though and Dru Brinkerhoff is a great vocalist. Final verdict: Simply remove five of your different styles of music and try something close-to "original" for a change.


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To Juice or To Blend?
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Anyone who has suffered from medical malpractice in Pittsburgh can share how traumatizing it can be. Patients have to put full trust in their doctors that they are making the right diagnosis and have ordered the right tests and interpreted the results correctly. But, in thousands of cases each year across Pittsburgh and the U.S. medical malpractice occurs including the failure to diagnose cancer.
LASIK eye surgery carries risks
For many Pittsburgh residents glasses are necessary to see clearly. Glasses can be annoying and expensive. The alternative, contact lenses, also require daily maintenance and care. LASIK eye surgery has become extremely popular as a surgery to correct eyes so that a person doesn't need glasses or contact lenses anymore. But, like all surgeries, surgical errors can occur.
A hysterectomy can lead to unexpected side effects
Many Pittsburgh women have had a hysterectomy. The surgery is one of the most popular among women and helps to treat fibroids, uterine prolapse and endometriosis among other conditions. Even though a hysterectomy is a popular surgery a surgery error can still occur that causes unexpected side effects.
Medical malpractice overview
When patients suffer as the result of a mistake made by a medical provider they have the legal right to hold that provider responsible. When a patient holds a medical provider responsible that person often files a medical malpractice claim. Many times medical malpractice claims result from surgical errors. These errors can often result in a patient's worsened condition or even death.
False alarms can lead to real problems for Pittsburgh patients
Most people in Pittsburgh have spent time in the hospital or have visited someone in the hospital. Many times, in hospital rooms, there are several different machines hooked up to monitor the patient's vital signs. It may seem that there is always some kind of beeping that is alarming for hospital patients and visitors. But to medical providers, these alarms are just part of their everyday environment. Thus, they may tend to ignore them from time-to-time or turn off an alarm and fail to diagnose a patient's medical emergency. Alarm fatigue is a patient safety concern that may cause serious injuries and even death.
Where medical diagnosing fails
Almost every Pittsburgh resident will visit the doctor this year. Some will visit for their annual exam and many more will need care because of an illness or injury. We all trust that our doctors will be able to tell us what is wrong and will help us get better but sometimes a doctor fails to diagnose our condition which can lead to a worsened condition.
A breast biopsy is often misdiagnosed
Many women in the Pittsburgh area will undergo a breast biopsy at some point. In the U.S. over 1.5 million women have them each year. A breast biopsy is performed after a woman finds a lump on her breast or if there is an abnormality found in a mammogram. When one of these things happen, a doctor removes a small amount of tissue, which is then tested.
What is a perforated esophagus?
Many Pittsburgh residents will undergo a surgical procedure this year. These procedures can be done in an emergency situation or they may be routine. Most surgical procedures occur without any issues, but occasionally a surgical accident can occur that causes a worsened condition.
Pennsylvania heart conditions and failures to diagnose
Heart disease is one of the top killers of Pittsburg residents. It claims thousands of lives each year and leaves many others with permanent disabilities. Although most people think of heart disease as something that affects older people, it can affect anyone. The failure to diagnose a heart condition can lead to a worsened condition, brain injury and even death.
A surgical site infection can be serious
Thousands of Pittsburgh residents will undergo surgery this year. These surgeries are medically necessary for many people and will hopefully bring them a better quality of life. One unexpected outcome of a surgery is a surgical site infection that can lead to a worsened condition, extended hospital stay and even death.


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WARNING: This is the OLD NZRASP server which will be turned off soon. The new server is at http://rasp.nz
Thermal Height Uncertainty, Thursday 3rd of October 2013 at 10:00
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The increase in boundary layer height (and the thermals in the layer) if the ground is 1 degree Celsius above predicted as can happen at a local hotspot. More info here.
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Someone asked me (in personal email) to give a summary of LCT's research [r1] in much the same way I summarized Faustman's research. Unfortunately, I just don't have the time to do that detailed a job. That Faustman post took me hours of research to put together. However, here is a summary of LCT's research, but with fewer details and fewer references. I'm sorry that I can't put more time into it.
The Pre-History of LCT's Research
In the 1970s and 1980s, it was commonly thought that type-1 diabetic's beta cells had been destroyed, and if they could just be replaced, their diabetes would be cured! This led to several attempts a cures, especially whole pancreas transplants, beta cell transplants, and drug treatments designed to get beta cells to regrow (such as human growth hormone). Of course, none of these worked very well, because the body's immunology attack on itself simply killed off the new beta cells. (Although if you gave immune suppressing drugs, you could get it to work a little bit, and you needed those drugs to prevent organ rejection of the new tissue, anyway.) This whole area of transplants is still being pursued, but it is no where near as successful as it was hoped to be decades ago.
When it became clear that the body's immunology attack kept going, some researchers tried the following approach: they encapsulated beta cells inside a wrapper and then implanted the bundle it in a person. The wrapper would need to be a very high-tech material that would allow nutrients and oxygen to flow in, and wastes to flow out, and insulin to flow out, and the chemicals which triggered insulin production to flow in. But if they succeeded, it would be like having a natural pancreas inside you, but protected from the immune system.
It's a great solution if you can do it, but very hard to do. In the last 20 years or so, there have been at least half a dozen companies that have tired this. Many have gone through several bankruptcies, name changes, and purchases by other companies. So far, none have been successful. In general, these companies try solutions from a "Chinese menu" one from column A and one from column B. Column A is the material inside the wrapper. The source of insulin. Column A has things like "human beta cells from cadavers", "human beta cells from live doners", "pig cells", "cloned embryonic stem cells", "cloned adult stem cells", etc. Column B is the wrapper material. Almost every company in this area has developed their own wrapper, and they all claim their wrapper is the best (and most of them try to incorporate good ideas from other's work, as much as they can).
One of these companies is LCT [r2]. From column A they selected pig beta cells, but from a special population of pigs that had lived for decades without contact with any other mammals on an island in the middle of nowhere. From column B they developed their own wrapper technology.
LCT's Research in the late 1990s
By the mid 1990s, LCT was ready to start human trials. These trials were underway in about 1998 when disaster struck. The disaster had nothing to do with their experiment. It had to do with the British food supply. Really! Mad cow disease hit, and it was caused by a previously unknown class of organisms called prions, which can be passed from animals to humans. Since LCT's work was basically transplanting pig tissue to humans, there was some concern about this, especially since at the time, there was no testing for prions either in the pigs or in the tissues being transplanted.
New Zealand reacted to all this by stopping the LCT phase-I clinical trial immediately. So LCT's most important task became to get their clinical trials started again.
LCT's Research in the 2000s
LCT then did several studies to show the safety of their technique. They showed that their pigs did not have a prion disease, that they were not likely to get a prion disease, that the technique was not likely to transfer it to people. that no one had ever gotten a prion disease from pigs, etc. Also, they improved their encapsulation technique. But all this was to no avail. New Zealand would not authorize any clinical trials. [d1]
This caused a lot of delay, and eventually LCT decided to run a phase-I trial in Russia (see below).
Meanwhile, almost all of the other companies working with encapsulated beta cells went out of business, or abandoned that line of research. In particular, pig cells turned out to be a better line of research than human cells (and that include all types of stem cells). Some companies that had been trying to use human beta cells (of various types) tried to switch to pig cells, when it became obvious that pig cells were working better, but this just emphasized the fact that LCT was way ahead of them, since they had always been using pig cells.
LCT's Current Clinical Trials
LCT ran their phase-I clinical trial in Russia. They hired an American company to oversee it and make sure that it was up to US FDA standards, but the trial was run in Russia.
They were going to just implant about 4 people in Russia (and about 4 more in New Zealand), but when they could not get approval in NZ, they did 2 extra people in Russia. One with a higher dose of islet cells. The results of this phase-I test in Russia were pretty good [r3]:
1 (out of 6) patients went 5 months without needing to inject insulin, but then needed to restart
4 patients required much less insulin before the treatment than after (some 40% less, some 20% etc.)
1 patient was not successful, requiring more insulin after the transplant, than before it
At about the same time, LCT released results of testing one of the people involved in their mid-1990s clinical trial [r4]. Basically, what they found from that exercise, is that the implanted cells were still there and still working (at least a little). But there was no way to know if this person's implants (now 10+ years old) were generating enough insulin to have any real effect on his BG, A1C, or insulin requirements. Even so, this was good news.
The most recent news from LCT is two fold: they have finally gotten permission to run a clinical trial in New Zealand [r6], and are working tords getting approval for a clinical trial in Denver (USA) [r5]. The New Zealand clinical trial they are about to start they are calling a phase-II trial. This makes sense, since it is after the Russian phase-I trial, but it doesn't make sense from a headcount point of view. They are only enrolling 8 people, so that is phase-I sized. I don't know if they will up the dose from their earlier trial; I certainly hope so.
I don't have a reference in front of me, but I thought that the Denver trial was going to be a standard phase-II trial: 50-100 people, etc. However, since they are calling their NZ trial a phase-II, maybe they will call this one a phase-III or add more people to it? I don't know.
The Future of LCT's Research
LCT has some really good results, but they are based on less than 8 people, and only about 6 months of treatment. So the future of their research needs to show better results, for longer periods of time, on more people.
Show better results: This is what I worry about the least. Most of the people in their phase-I trial were given the absolute minimum dose of new islets, and yet they had large drops in their insulin needs. One person used no insulin for a period of time! Since actual transplants can use 2x, 4x, or many more times the number of islets, I think it is very reasonable to assume that higher doses will result in less insulin needed. In many cases, no insulin needed.
For longer periods of time: For me, this is the biggest worry. How long will these new islets last? Or, how often will they need to be replaced? There are two potential problems here. The first is that islet cells may have natural lifespans, which cause them to stop working after a certain number of years. There has been some research suggesting this (sorry: no references for this), but the exact lifespan is not known. Secondly, and more importantly, the encapsulation or transplantation of the cells may cause them to start to die off. This could kill of the transplanted islets much more quickly. For example, if the wrapper is not "good enough" islet cells may start to run out of oxygen, and very slowly die off over weeks or months. This has been a very real problem with other company's encapsulating technologies.
On more people: Because so few people have been given these islet transplants, there is always the possibility that there is some major problem that we just don't know about, because not enough people have gotten the transplant. I don't think that is very likely, but as more people are treated, we'll develop more certainty that it is safe.
My Opinion of this Research
My personal option of this research is mixed. I think that it is very likely to work, eventually. But I'm not sure how long it will take for them to tweak out all the problems. Also, it requires surgery. And I suspect that the early people to get it may need follow up surgeries every 5 or 10 years. On the other hand, I think that there are lots of people who, if you tell them "we can cure diabetes for 10 years for $50k and a three day hospital stay", many will do it. And that is a very reasonable goal for this technology within the next 5 to 10 years. And in 10 or more years, it may be cheaper or last longer, or both.
If you want to follow LCT, I recommend their web site: http://www.lctglobal.com/, which is very glossy.
There is another source, which I recommend only with serious reservations, and that is http://www.islet.org/forum/wwwboard.htm. This forum is run by an LCT cheerleader. He aggressively censors people who say bad things about LCT, or ask awkward questions. (And yes: I've been banned from the group several times.) I also believe that the forum owner makes many posts under many different names, to create a sort of false consensus on how wonderful LCT is doing. I have definitely seen the list owner post under multiple different names, I'm just not sure how many of the names on the board are real, and how many are fake. My best guess is about half are fake, but I'm really not sure.
More Discussion
[d1] Obviously there is a huge political saga here, which I will not get into.
Some References
[r1] My tracking of LCT is available here: http://joshualevy.pbwiki.com/DiabetesCureReadyForHumanTrials#LivingCellTechnologiesDiabecell
[r2] LCT home web page is here: http://www.lct.com.au/
[r3] http://www.scoop.co.nz/stories/SC0803/S00061.htm
This is a news article with selected data from the first 6 months of the Russian phase-I trial.
[r4] Results of some tests on a guy who had this done 10 year previously: http://www.diabetesincontrol.com/results.php?storyarticle=4688
[r5] http://www.cwdfoundation.org/Grants2008/LCTBDC.html
[r6] Press reports on the New Zealand approval:
News and updates on potential cures for type-1 diabetes, that are in human (or clinical) trials.
Monday, December 15, 2008
LCT's Research
Posted by Joshua Levy
Labels: LCT, Non-honeymoon, Phase-I
2 comments:
- Graham56 said...
I too have been following LCT's work and I agree with most of what you have said. One thing I do wish to clarify is that the 'surgery' required for the LCT transplant is minimal, since it is performed using laparoscopy (effectively a big needle). As a result it does not require a major surgical team and the patient is only in hospital for a couple of hours. I think most people would happily undergo that, even evey few years, if the proceedure is beneficial.
- January 5, 2009 at 9:18 AM
- Joshua Levy said...
That's a good point. I'll update the posting to say "minor surgery (no overnight stay)" or something like that.
Joshua Levy
- January 5, 2009 at 12:19 PM
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Support and Secret Collaborations!
Goldenrod might be just a weed and a horrid allergen to some, but it is pretty and provides support to butterflies!
If you'd like to play, here's TNChick's link!
Also, here's my collaboration with Julie this week:
Secret Collaborations! What's so secret about it? She went through my pictures and matched this up to hers (which is on the right). Well done, I say!
Posted in Photo Hunt, Saturday Collaboration | 12 Comments


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Amazon.com Inc. widely missed Wall Street expectations in reporting a third-quarter loss of $274 million, sending its stock down in after-hours trading.
The world's largest online retailer also forecasted fourth-quarter results that could range from a $490 million loss to a $310 million profit.
Amazon's net loss, amounting to 60 cents a share, was much lower than the 8 cents a share that analysts in a Thomson Reuters survey had anticipated. For last year's third quarter, Amazon earned $63 million, or 14 cents a share, and sales were $9.4 billion.
Quarterly sales for the world's largest online retailer rose 27% to $13.8 billion from $10.9 billion. Analysts had expected revenue of $13.9 billion.


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Pain-free typing
People plagued by repetitive strain injury can throw away their keyboards.
Inventor Peter McAlidon has come up with "orbiTouch", a pair of domes that fit
comfortably under your hands. Each dome can be pushed in eight positions
corresponding to the eight main compass directions (N, NE, E, SE, S, SW, W and
NW). Different combinations of these movements emulate a Qwerty keyboard
(www.keybowl.com/products/ howitworks.htm). Trials show that most people manage
to get back up to 52 per cent of their original typing speed after just five
hours of practice, says McAlidon.


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You earn how much?! Breaking the workplace taboo
When Joel Gascoigne launched his start-up, he outlined some founding values of the fledgling company. One of the most important, he stressed, was openness.
But Gascoigne's commitment to this principle went further than most, and resulted in him implementing a pay program at Buffer – the social media publishing platform he co-founded in 2010 – that breaks the most entrenched of workplace taboos: revealing one's salary.
Now, rather than clandestinely speculating with colleagues at the water cooler, each employee knows exactly how much their colleagues earn, and Gascoigne is even considering making their salaries public.
"We have run Buffer with a focus on self-improvement since the beginning, where co-workers talk regularly about what they are working on to improve themselves," he told CNBC. "It's this openness and transparency which led to salary transparency feeling like simply a natural progression for us."
via Yahoo Finance.


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Whether you're traveling with your canine or want to be sure that it is taken care of in an emergency, there are a variety of dog supplies online that can help you. You'll find some of the most affordable dog accessories online at SOS Survival Products, including double-sided dog dishes, tick removers and heavy duty leashes. We even have a pet product that allows you to muzzle your dog, which can be important for travel or when in situations where your pet may not be comfortable.
Other affordable pet products that we offer are a spiral ground stake that enables you to keep your dog outside without it running off. Dog auto harnesses, which enable you to ensure your dog's safety while you travel without having to cage them, are available as well. We also offer portable accessories for dogs, such as plastic pet food lids and a collapsible dog bowl that can be used for food or water.


text: C++ Programming I 36-2550 The course introduces the student to programming using the C++ language. Students learn basic programming of graphic and business applications in C++. Instruction emphasizes good programming practice, programming structure, and object-oriented programming. Prereqs: 36-1501, Intro to Programming: Theory and Concepts*,or,35-2550 Intro to Prog: Theory & Practice Coordinator : Janell Baxter email@example.com Students will be able to... develop C++ programs using Microsoft Visual Studio IDE (Integrated Development Environment).   write appropriate C++ commands and constructs to convert problem statements into computer code.   define best practices in object-oriented programming.   describe foundational object-oriented programming concepts such as inheritance and encapsulation.   recognize the differences between procedural and event-driven programming.   Back to All Courses


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The issue of focus is an ever constant problem for anyone in the current society, but for chess players addressing it is particularly important. As Garry Kasparov once wrote – being able to concentrate fully on what's happening on the board during a game and ignore everything else – is perhaps the most important skill for a chess player. That was written more than 25 years ago, and is true today more than ever.
When starting to study chess, I also read that chess, among other things - helps kids to improve their attention span, and I found that to be true at the time, but that was before computers, internet, mobile phones and other distractions came along. Maintaining focus during the game is easier because old habits kick in, and we are not allowed to use computers during tournaments, but during preparation – it is a challenge. If Anatoly Karpov was known to prepare for his Candidate Match games with the TV on, what can the mere mortals do? I'd like to suggest the following strategies for focus and motivation:
- set up clear study plans with definable objectives over longer term
- create habits that involve at least minimal daily chess study (e.g. solving 3 puzzles a day)
- set up routine for regular longer chess sessions when you can dedicate an hour or two of uninterrupted time
- get a study buddy or coach involve to keep yourself responsible to someone
- turn off internet or blocking distracting websites
- spend time away from the computer, with the chess board and books
- emulate playing environment while training – using chess clocks when looking for a move, having a board in a quiet room, etc
- during the tournament games – be mindful or where your clock time and attention goes – during your turn and your opponent's
- during longer games – have regular breaks to make sure you have blood flowing to the brain and you don't play a "blackout" type of move that you later can't explain yourself
- arrive for tournament games a bit early, so that you can get into tune before the game starts, and don't accidentally play a wrong opening move because you are still thinking a traffic jam you were in on the way to the game


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Build Bridges Of Minds And Hearts: PM @SAARCPrinter-friendly version |
Regional integration in its real sense can be advanced only when there is an intermingling of people and ideas, says PM Bhattarai, addressing the 18th SAARC summit in the Maldives.
Prime Minister Baburam Bhattarai has underlined the need to develop SAARC as an institution in tune with the 21st century. Addressing the summit he said: "Yes, we must build physical bridges among ourselves, but more important would be to build the bridges of minds and hearts. We believe regional integration in its real sense can be advanced only when there is an intermingling of people and ideas."
What follows is the complete text of his address:
Text of Statement by PM Baburam Bhattarai at the 17th Meeting of the Heads of State or Government of the South Asian Association for Regional Cooperation (SAARC), Addu City, Maldives, November 10, 2011
Mr. Chairman
Distinguished Delegates and Observers
Ladies and Gentlemen
At the outset, may I express my warm congratulations to Your Excellency, President Mohamed Nasheed, on your assumption of the Chair of the SAARC. I am fully confident that with your vision, wisdom and leadership, SAARC will be led to a newer height of dynamism and success during your tenure.
2. I would like to express our gratitude to Your Excellency and through you to the Government and the people of Maldives for the warm reception and generous hospitality extended to us ever since our arrival in these pristine islands and for the excellent arrangements made for the Summit. I congratulate Your Excellency, President Nasheed, for putting an extra and gratifying effort to expand the outreach of the Summit to the southern hemisphere.
3. I also take this opportunity to express our appreciation to His Excellency Lyonchhen Jigme Y. Thinley, the outgoing Chairman of our Association, for the sterling leadership provided to SAARC since the 16th Summit.
Mr. Chairman,
4. I have brought with me greetings from the 27 million toiling but proud people of Nepal, who have recently liberated themselves from the age-old feudal monarchy and autocracy. I have the distinct pleasure to share amongst our friends that the course of the peace process that we charted after years of struggle is bearing fruit through dialogue, understanding and consensus among major political actors in the country. Early this month, we made a significant breakthrough in the crucial issues of integration and rehabilitation of the Maoist army combatants and remaining issues of the framing of the new constitution through the first ever elected Constituent Assembly in the Nepalese history. This has brought the peace and the democratic process closer to its conclusion. We believe that the process of political and economic transformation should go parallel and we are resolute to deploy all our efforts to fulfill the aspirations of our people for a peaceful, stable, equal, just and prosperous future.
5. In its 26 years of existence, time has come for SAARC to take stock of achievements, identify challenges and chart out a course for future action. Despite being a cradle of major world civilizations, rich in history, culture and natural as well as unparalleled human resource endowment, our peoples' aspiration for progress and prosperity remains unfulfilled. In the midst of pockets of growth and prosperity, the region is marred by widespread poverty, inequality and unemployment. The adverse impact of environmental degradation and climate change is taking its toll on the most vulnerable for no fault of their own. Terrorism, trafficking in women, children and drugs and other transnational crimes pose serious threat to peace and stability in the region. Our intra-regional trade and investment flows remain one of the lowest in the world mainly due to constraints like poor physical connectivity, energy shortage and trust deficit. Flow of goods, people and ideas remains constrained and potentials under-realized. Implementation of SAFTA is hindered by tariff, non-tariff and para-tariff barriers and suffers from slow progress in reducing the number of items in the sensitive lists and constraints of trade facilitation.
6. Challenges abound. However, the region possesses enormous resilience and capacity to transform the challenges into opportunity. We have been able to set norms, build institutions and establish linkages among ourselves in social, economic, trade and environmental sectors. SAARC Development Fund, South Asian University, SAARC Food Bank, commencement of SAFTA, SAARC Social Charter and conclusion of a host of other regional instruments constitute important milestones. They all provide a basis for cooperation. But achievements so far have not been up to our expectations. Unleashing of the region's full potentials is what our people have been eagerly awaiting from us. This can be achieved through building on the strength of our rich endowments, including shared cultural heritage and vast network of social capital. This is where comes in the importance of the very thoughtfully conceived theme of the present Summit- Building Bridges.
7. Smooth physical connectivity is critical for building bridges in terms of mobility of goods, services, people, ideas and innovation in the region. Present state of physical connectivity poses a major constraint in realizing the long-cherished vision of the South Asian integration. The region still lacks world class network of highways, railroads, seaports and air connection. If we have any lesson to draw from other regions, connectivity perhaps comes as the most important element that we cannot further delay in emulating. It is our conviction that development of SAARC multi-modal transport system by upgrading existing infrastructure and building new ones as well as by providing smooth transit facilities to land-locked member states would greatly facilitate deeper integration of the region. The proposed draft Regional Railway Agreement and draft Agreement on Motor Vehicles should be accorded due priority for their early conclusion. Our endeavor to build bridges should touch all dimensions of South Asian lives, be it social, cultural, physical, or in terms of transportation and communications. Regional energy connectivity and energy trade also become important elements in this regard.
8. Yes, we must build physical bridges among ourselves, but more important would be to build the bridges of minds and hearts. We believe regional integration in its real sense can be advanced only when there is an intermingling of people and ideas. We note with satisfaction that the South Asian University has entered into the second year of its intake. It is an important achievement that should be complemented by similar other efforts to encourage people-to-people contact, including through collective promotion of culture, music, sports, entertainment and intra-regional tourism. It is gratifying to note that the idea of creating South Asia Forum as a mechanism for public-private partnership has been realized. The unique nature of this Forum may be preserved with an expanded base of participation in the future.
Mr. Chairman,
9. Trade constitutes the lifeblood of economic prosperity and it should be treated as such. Favorable trade and investment environment kindles economic growth, helps improve the living standards and facilitates greater interaction among the people. Elsewhere, we have seen examples of prosperity bringing about peace and stability which in turn helps consolidate democracy and mutuality of interests. There is no reason why such an experience cannot be emulated in our region with full implementation of SAFTA in its letter and spirit.
10. Effectiveness of SAFTA is contingent upon crucial factors, such as, removal of trade barriers, reduction of items in the sensitive lists, substantive and workable trade facilitation measures, and smooth transit facilities. Overcoming the hardships and capacity constraints that the LDCs in the SAARC family suffer becomes important for them to be able to augment their share of trade in the region.
11. Environmental degradation and climate change have posed serious challenges to the wellbeing of our people in the region. All our countries are prone to the devastating effects of global warming in the form of fast retreat of glaciers in the Himalayas and the dangers posed by the outburst of glacial lakes, sea level rise and erratic weather patterns and climatic disasters. The trend is likely to exacerbate. While building robust regional institutions and norms to collectively address this common challenge is essential, at the international level, they should be complemented by transfer of resources, technology, and capacity building for adaptation and mitigation.
Mr. Chairman,
12. The increasing gap between the rich and poor has given way to enormous stress on social harmony, peace and security in the region. It is a big blot on all of us that the largest number of poor in the world live in our region. This challenge demands that poverty eradication strategies be comprehensive and socio-economic and political development processes more people-centered, inclusive and equality and justice-based. Some of the internationally acclaimed poverty eradication strategies, such as, rural micro-credit scheme, have their origins in South Asia. They need further development and expansion with focus on women and disadvantaged sections of the society. Despite some quantitative changes, the fundamental politico-economic characteristics of our societies on basic class relations cannot be assumed to have undergone any qualitative change as long as we continue to lack on objective and holistic approach to development and fail to locate the solution in the need to bring about structural change in the existing archaic and retrograde relations of production, especially in the vast countryside. In the context of feminization and ruralization of poverty, our efforts to eradicate it should focus on structural changes in traditional production and social relations, promotion and industrialization of agriculture, indigenous skills and small scale industries and empowerment of women and marginalized communities. The existing regional normative standards in the social sector and the SAARC decisions and commitments need to be internalized in national policies and programs. Active and forthcoming involvement of the civil society and the private sector in the region may add value to this process.
13. The Success of the SAARC process as a whole will be judged by what we deliver to our people, and not by what ritual pronouncements we make. Commencement of the SAARC Development Fund's social window is a welcome beginning in realizing our efforts to eradicate poverty from the region. Its activities can be made more effective if they are harmonized with the priority areas enunciated in the SAARC Social Charter and the SAARC Development Goals. Early opening up of the Fund's infrastructure and economic windows is important for it to be able to bring tangible results with wider impact on the lives of the masses in the region.
Mr. Chairman,
14. Peace and security are some of the most important pre-requisites for a harmonious society. The scourge of terrorism and other transnational organized crimes perpetrated by abusing modern technology calls for cooperation, information sharing and better understanding among the law enforcement agencies of our region. While we have defined norms and mechanisms to deal with such a menace, enhancing efficacy of those mechanisms and continuous strengthening of the legal framework in tune with the changing complexities would be a useful strategy to pursue. We are committed to work closely with fellow SAARC member States in our fight against such crimes.
Mr. Chairman,
15. While we get thrilled with the international perception that the 21st century belongs to Asia, South Asia should by all means prepare itself to act and reap its fair share in the process. We the leaders should rise up to the challenge as our enterprising people rightly expect from us to create enabling environment and provide ways and means for them to fully unleash their potentials. This will surely help change the face of our region. The best we can do in the long run would be to synergize all our efforts based on the complementarities of South Asia and to realize the objectives of greater integration of the region leading to the South Asian Economic Union as envisioned by the 11th SAARC Summit in Kathmandu. For this, we need to think and act beyond the box of 'business as usual' attitude and collectively remove barriers and impediments and redeploy our combined efforts to reinforce the bonds of South Asian unity. As a founder and committed member of SAARC, Nepal stands ready to play her due role in the family of South Asian Nations. Let us turn South Asia into a power-house of growth and development and a beacon of human civilization in the 21st century. Let us collectively think big and act big.
I thank you.


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Espa ol
There's no longer any excuse for stereotyping Native American music. Sure, pow-wow drums, haunting cedar flutes and hypnotic chants are heard on this disc, but there's also much more going on. Traditiona-sounding pieces by Blackfire, R. Carlos Nakai, Radmilla Cody, Ed Lee Natay and Thunder Hill will amply please purists, while Buffy Sainte- Marie's rockish interlude, Louie Gonnie's spectral soundscape of voices emerging like passing time, Walela's blend of gospel-tinged vocal grace and electronic shading and Nakai's handy fusion with Hawaiian slack key guitarist Keola Beamer toss different flavors into the pot. Comprised of 14 largely meditative pieces, the album could have benefited from a few more upbeat offerings to break up the flow, but the indigenous splendor presented here will provide medicinal respite from life's everyday ailments, and the Oxfam-supporting proceeds from this and others in the Think Global series show that both hearts and actions are in the right place.
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Federal Budget 2017
There are around 2 million small businesses operating in Australia, employing 4.8 million people, almost 50% of the nation.
Queensland is home to almost 20% of small businesses in Australia, with 406,000 small businesses employing around 43% of the private sector workforce. SME's also make up 99% of all businesses in Queensland, contributing around $100 billion to Queensland Gross State Product.
With these staggering figures in mind, supporting small business success is critical to maintaining the overall health of Queensland and Australia's economy.
The 2017-18 Federal Budget represents the perfect opportunity for the Australian Government to introduce measures to kick-start the small business economy in a time of extraordinary transition.
To this end, there are five key priorities that the Chamber of Commerce and Industry Queensland believes the Federal Government must address in the 2017-18 Budget to support small businesses to grow, invest, and employ.


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Case Studies: Stories of children and youth new to Canada
Immigrant and refugee families may have faced considerable hardship and challenges before coming to Canada. Part of the role of health professionals is to help newcomers integrate and adapt to their new lives.
The case studies in this section provide common examples of specific health issues that young newcomers to Canada and their families may face. These short vignettes are fictitious and based on the clinical experience of multiple contributors. They are intended to help clinicians become aware of such issues and how they can be addressed.
Our thanks to the staff at the following organizations for their thoughtful review and comment on these vignettes: Thorncliffe Neighbourhood Office, Immigrant Services Society of B.C.
A young child with possible tuberculosis and HIV/AIDS
Region of origin
Democratic Republic of Congo
Some countries continue to experience war, extreme poverty, child labour and child prostitution, such the Democratic Republic of Congo (DRC), Sri Lanka and Sudan.
Nzuzi is a 6-month-old girl born in Canada. Her family arrived in Toronto from the DRC when her mother was 7 months pregnant, so she had no routine prenatal care.
For the past 2 weeks, Nzuzi has not been feeding well. She has a cough and low-grade fever. She is underweight, febrile (temperature 38.5°C) and tachypneic (respiratory rate 60 breaths/min) with fine crackles. She has an enlarged liver and spleen, and enlarged cervical lymph nodes. The differential diagnosis includes tuberculosis and HIV/AIDS.
Knowing that the rape of women in Eastern Congo by rebels is a common method of terrorizing local villages, how would you compassionately and carefully ask about the mother's health and whether she might have been raped and infected with HIV?
Key points
In this case, although Nzuzi might simply have a pneumonia, given that the family is from Africa and the presence of hepatosplenomegaly, the most likely diagnoses are TB or HIV/AIDS. However, both diagnoses would mean contact from someone else, and for HIV/AIDS that would mean that Nzuzi's mother would have HIV/AIDS. Her mother may or may not suspect or know she has HIV/AIDS. This problem must be approached carefully and compassionately. The mother will need to be referred to an adult centre for diagnosis and management.
Related information
A young child with possible HIV/AIDS
Region of origin
Parents may be reluctant to have their child tested for certain illnesses, such as HIV and tuberculosis, because they fear results could adversely affect their immigration status.
Ateefa is an 18-month-old girl whose mother is from Malawi. Ateefa presents with a history suggestive of HIV/AIDS, but her parents refuse testing, fearing it might adversely affect their immigration status and put them at risk of deportation. You take the time to explain that diagnosing HIV would benefit Ateefa because she could start on antiretroviral therapy.
After extensive discussions through interpreters, the family agrees to testing and the child is started on antiretroviral therapy and appropriate preventive therapy for opportunistic infections. Two siblings are also tested and found to be HIV-negative, much to the relief of the parents.
Knowing that an 18-month-old child diagnosed with HIV means that the mother also has HIV, how do you approach the family and explain the need for HIV testing for the child as well as for all family members?
Key points
The problem is challenging. To start, the health care professional should explain the features of HIV/AIDS to the family, stressing how patients with HIV/AIDS in Canada are not shunned or scorned as they may be elsewhere. In Canada, people with HIV/AIDS can live a long, normal life with good and careful treatment.
Related information
A young boy with behavioural difficulties at school
Region of origin
Some men and women come to Canada to work, leaving children to be raised by grandparents or close relatives back home. Some of these children are brought to Canada later, to live in an unfamiliar culture and with parents they do not really know. Immigration status is also a factor. Visitors who stay in Canada, including children born outside the country, have no immigration status, whereas children born in Canada are Canadian citizens.
Jamal is a 10-year-old boy. He comes to your office with his mother, who is concerned about his progress and behaviour at school. His first report card shows that he is failing many subjects. The teacher also says he acts up in class, is often disobedient and disrespectful, and fights with other students.
Jamal's mother came to Canada 8 years ago to attend school and work. From 2 years of age until 6 months ago, Jamal lived with his grandmother in Jamaica. He now lives with his mother and two half-sisters in Canada.
What might explain some of Jamal's difficulties in school? How would you try to help Jamal and his mother?
Key points
Jamal could certainly have a learning disability or ADHD (attention-deficit hyperactivity disorder). But given the history, his school difficulties could relate to moving to a new country and living with his mother, with whom he may have little rapport or attachment. Referral to a community agency working with West Indian families or for mental health or family counselling would be indicated.
Related information
A young boy with abdominal pain
Region of origin
Eastern Europe
Roma refugees face considerable discrimination in regions such as Eastern Europe, particularly Romania, Hungary and the Czech Republic. At the time of writing, Citizenship and Immigration Canada considers these safe countries, where persecution is unlikely to occur. Therefore, refugee claims are less likely to be considered legitimate.
Marko is a 6-year-old boy presenting with abdominal pain who sometimes has accidental bowel movements. He has been in Canada for the past 4 months and recently started school.
Marko and his mother speak Hungarian and Czech, and are just learning English. His mother is vague in providing some details of their history and background, including where they have lived or their immigration status. It is also not clear which immunizations Marko has had or what schools he has attended. There are few details about his father.
Reflecting that Marko and his mother might be Roma, and perhaps refugee claimants, how would you obtain information about him and his family history so that you could help?
Key points
While there might be a specific organic cause for Marko's abdominal pain, it is likely related to some of the emotional and psychosocial problems experienced by his family. Some screen laboratory tests may be necessary. A more thorough psychosocial history is necessary, along with referral to a community agency that works with immigrant families and with Roma in particular. Further, if Marko's immunization is not well documented, he may need to start on a new series of immunizations.
Related information
A young girl having difficulties at school
Region of origin
Some immigrants come to Canada from countries that experience crime and violence associated with drug trafficking, such as Colombia and Mexico.
Maria is an 8-year-old girl in Grade 3 at a local school. She lives with her mother and 5-year-old brother, who is in junior kindergarten. The family left Colombia 3 years ago because of the political situation. Maria's mother works part-time in a doughnut shop and is trying to attend an adult language class to learn English. Maria's father is still in Colombia, and the family hasn't heard from him for the past 9 months.
Maria was referred to a community paediatrician because she is having difficulty with her school work. She is having problems learning to read and paying attention in class, and needs a lot of supervision to get her work done. Maria can be disruptive in class and picks fights with the teacher and students.
What are the possible explanations for Maria's difficulties at school? How would you try to help her?
Key points
There are many reasons for Maria to have difficulties with school. She may have a learning disability or ADHD (attention-deficit hyperactivity disorder) but her behaviour may also be related to limited school experience, the family's emotional and psychosocial problems and her mother's inability to help Maria with her school work. An open discussion with the school officials and teachers would be helpful. The school may consider placing her on the referral or wait list for a psychoeducational assessment through the school board. The school may also have some volunteer tutors who could help Maria with her homework. Referral to a community agency working with Latin American families would also be helpful.
Related information
A young girl with headaches
Region of origin
Russia, via Israel
Some families come to Canada via other countries, such as Afghanistan via Pakistan or Russia via Israel. Indirect routes can pose a challenge when determining immunization status, for example, or for assessing disease risk based on region of origin.
Deborah is a 10-year-old girl. She presents with headaches, which she's had 3 or 4 times weekly for the past month. Deborah has been sent home from school on many occasions. You are impressed that she speaks Russian and Hebrew, and is now learning English and French. However, you don't know precisely where she has lived or what immunizations she has received.
How would you determine Deborah's background, immunizations and possible causes of her headaches?
Key points
Health professionals must keep the specific causes of headaches in mind, such as raised intracranial pressure or migraine headaches. But with Deborah, the headaches may also be a reflection of her move to a new home, the loss of familiar friends and school in Israel or Russia, and family stress. Rather than start by ordering a CT scan, you might consider symptomatic treatment, documenting with a headache diary, a more thorough psychosocial assessment and, possibly, referral to a community agency working with immigrant families. Further, if there is any question about Deborah's immunizations, she may require a full set of vaccines. Some centres do serology for different infectious diseases (e.g., polio, measles, varicella) and provide immunization where a child does not have immunity. For a 10-year old girl from Russia and Israel, this approach may be appropriate.
Related information
- Robert Hilliard, MD
Last updated: April, 2018


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Delay • Effects • Restoration • Reverb
July 14, 2009
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This post focuses on convolution as it applies to audio – the capturing and reapplication of the qualities of sound. A few years ago some new-fangled audio processing...
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This post focuses on the placement of sounds in the stereo image during the mix process. Proper use of stereo imaging in a mix is probably almost as important (or even more...
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© Copyright 2016 Dan Connor Consulting


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Students from Buckswood School are celebrating this week after another successful year of A Level and GCSE results.
The Guestling school bucked the national downward trend with the number of students achieving A*-A grades rising to 26 per cent, which is also a rise of two per cent on their 2014 performance.
GCSE results are in line with the national average for A*-C passes but as with many other independent schools, Buckswood sit some of their core subjects at the harder IGCSEs and the A* - C pass mark was 80%.
Head teacher Mark Redsell said: "We are pleased with this year's results. Buckswood offers more than just GCSEs, and this year's results are a credit to the hard work of our students and teachers.
"From next year even more of our core subjects will be sat in the harder IGCSE system and judging by out IGCSE results over the last few years, this qualification better suits our students."
All 64 Buckswood Upper Sixth Form are now off to university with the graduates all accepting places in the UK's top 50 establishments.
Notable results include Salem Shammakh got A*AAB and is going on to study mechanical engineering with advanced design and innovation at Bath University, Konstantin Korsun achieved A*AAB and is reading economics and management at Kings College London.
Alex Ashton got AABB in maths, accounting, business and Spanish, Victoria Kovalenko earned A*BB and is going on to study politics and international relations at the University of Kent.
"Buckswood has always believed in offering a wide curriculum, giving students many opportunities to gain experiences and qualifications that make them stand out from the crowd" Mr Redsell said.
"This summer has seen the School double in size with the acquisition of a new Woodlands Activity Centre, Farm and Stables, more land and a 26ft Yacht to broaden our students education both inside and outside the classroom across land and sea!"
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In a surprising turn of events US Secretary of Defense, Robert M. Gates, has made this revelation: Charlie Sheen IS Captain America.
Mr. Sheen alluded to his superpowers during a NBC interview when he stated that he has tiger blood flowing in his veins as well as Adonis DNA.
A reporter for the Hoboken Daily Shopper cornered Secretary Gates and demanded to know the truth. Gates buckled under the intense pressure.
"The truth," Secretary Gates replied, "is that Charlie Sheen really does have those attributes. The super soldier formula was partly derived from tiger blood as well as genetic material from Adonis. Charlie Sheen's womanizing, supposed drug use, and seemingly bizarre behavior, has been a screen for his role as champion for America."
Charlie Sheen, in his role as Captain America, has been secretly fighting a war against the forces of evil for years.
The real reason why the Egyptians were able to get rid of their dictator? Charlie Sheen was there behind the scenes punching out then President Hosni Mubarak.
The liberation of Eastern Europe from communism? Charlie Sheen was there punching out Gorbachev.
Unfortunately, the great American hero can't be everywhere at once: James Franco was able to drain the life out of the latest Academy Awards ceremony.
When Mr. Sheen was told that Mr. Gates had "outted" him, he seemed relieved. "At last I can live my life out in the open. I couldn't keep the crazy behavior going on forever. It was sooo draining."


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Evolutionary Trap bites Bufo on the Bum
The fight against the invasive and noxious cane toad, Bufo marinus, has a new weapon with the discovery that meat ants (Iridomyrmex reburrus and I. sanguineus) in Northern Australia are able to overpower and eat juvenile cane toads.
This is because the cane toads evolved in vastly different conditions in the Americas, with completely different survival challenges, and the invading species is now caught in an 'evolutionary trap', according to cane toad expert Professor Rick Shine
Prof Shine and his Team Bufo at Sydney University – Georgia Ward-Fear, Matt Greenlees and Greg Brown – measured habitat use and activity patterns in meat ants, metamorph cane toads and metamorphs of seven native frog species (Litoria, Limnodynastes, and Opisthodon ornatus spp) in the laboratory. The study was funded by the Australian Research Council, and was Georgia Ward-Fear's honours research project.
They found that metamorph toads (ones just metamorphosed from tadpoles) were at risk of attack from the meat ants because of their behaviour. The young cane toads are active during the day and prefer open habitats, unlike native frogs, which are nocturnal and hide in vegetation during the day when the meat ants are seeking food.
Meat ants are found in large numbers around tropical waterholes also frequented by cane toads. They are basically scavengers, Prof Shine said, but the worker ants, averaging 10 mm in length, had often been observed eating small toads.
This led the team to suspect that the toads were not adapted for their habitat – "there might be some kind of mismatch between the invader and its newly invaded range, for example, something about the toads' behaviour that makes them vulnerable to a predator that poses little danger to native frogs."
Unlike the native species which breed during the wet seasons, when there are large stretches of water on the Northern Australian coastal floodplains, B. marinus breeds during the dry season. The waterholes are surrounded by large stretches of drying mud, the average temperatures are around 30C and the humidity is very low. Large numbers of metamorphs are constrained to stay close to edges of waterholes or run the risk of desiccation.
It's hypothesised that the metamorphs feed during the day to avoid being cannibalised by larger cane toads. However, as well as being active in the day, the young toads seem not to possess awareness of the dangers posed by the ants, and so fail to detect and evade approaching ants. What's more, once under attack, they exhibit poor locomotor ability: short slow hops, reflecting their small size and short limbs; and frequently rely on an ineffective defence mechanism (crypsis) when attacked.
![Meat ant & cane toad](/image/img/Meat ant_cane toad.jpg)
A worker meat ant, Iridomyrmex reburrus, attacking a a juvenile Bufo marinus near a waterhole
In order to test the metamorphs' mobility skills, the team built a special runway on which they could compare the sprint speed and endurance of the toads against the various species of native frogs.
The animals were encouraged to run by lightly tapping it on the urostyle with a blunt rounded object. "Each time the metamorph ceased hopping, we tapped it lightly on the urostyle. We recorded the time taken to reach the 0·33 m, 0·66 m and 1·0 m marks on the runway, and for statistical analysis we used the single fastest speed over any 0·33 m segment as a measure of sprinting capacity," said Ward-Fear, lead author of a paper on the research.
"If no hopping response was elicited after five taps, the metamorph was considered exhausted and this time was recorded as the metamorph's endurance."
Compared to the native frogs, the toad metamorphs were smaller and slower. "On average, the metamorph cane toads were smaller (in both mass and length) than all other species tested except O. ornatus and L. bicolor. Toads also had the smallest tibia length, both in absolute terms and relative to their body size ," Ward-Fear noted in her paper.
"Toads recorded the slowest speeds over 33 cm and had lower average endurance levels than did any native species except O. ornatus."
The combination of these factors – daytime activity, a lack of awareness of the threat from the ants, and smaller, slower hops – puts newly metamorphosed toads at risk of becoming prey rather than predator, a risk the native frogs have evolved to avoid.
"The end result of this mismatch between traits of metamorph cane toads, which evolved in the Americas, and the ecological interaction between metamorph toads and meat ants in tropical Australia, is an 'evolutionary trap'." Shine said.
"The characteristics that increased toad survival where they evolved in the Americas are now a disadvantage, because the toads are facing different challenges in Australia – challenges they have not evolved to deal with. Such evolutionary traps should be especially common for invasive species, because so many aspects of their environment differ from those in which the traits of that species evolved."
"The results are interesting not only because they reveal the cane toad's Achilles' heel – a weakness that could be exploited to help control the spread of the toxic toad – but because the same 'evolutionary trap' could be used to snare invasive species elsewhere.
Georgia Ward-Fear et al (2009), 'Maladaptive traits in invasive species: in Australia, cane toads are more vulnerable to predatory ants than are native frogs', was published online in Functional Ecology, on 31 March 2009.
©Sue Cartledge 2009


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The camellias are blooming all over Perros-Guirec at the moment and filling our lives with such wonderful colour. These are in my garden on a huge shrub by my entrance so they can be seen and appreciated by all who pass down the lane.
Saturday, March 28, 2015
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Author Profile
Peter Frase
Peter Frase is the vice chair of the Hudson Valley chapter of the Democratic Socialists of America, and a member of the editorial board at Jacobin magazine. He is the author of Four Futures: Life After Capitalism (Verso, 2016).
The Inside-Outside Approach to Bernie 2020
Endorse, but play the long game. MORE
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Before we can call work 'noble,' we have to agree on what it is. MORE
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Cross-posted from Jacobin A month or two ago, Bhaskar Sunkara came to me with the idea that we could, on a short deadline, turn our long-running discussions about the future of progressive politics... MORE
Uprising · October 22, 2012


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LVS commissioned a service operation some two years ago, employing the latest vehicle diagnostic systems from Omnitec Modular Integrated Diagnostics and leading vehicle data systems from Autodata. This and our fully trained and professional technicians, coupled with purpose built workshops enables us to undertake service and repair work on all UK franchise cars and light commercial vehicles, whilst still retaining the manufacturer's warranty qualification.
To complete the picture LVS has forged a strong relationship with an established professional insurance approved body-shop, allowing us to offer a professional accident management and accident repair facility and completing our 'one stop' vehicle management facility.
* All vehicle images and car descriptions on this site are for illustration and reference purposes only and are not necessarily an accurate representation of the vehicle on offer.
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This London-based photorealist artist uses paint to chart his obsessions. And since he first painted his record stack as a private musical memento to take with him when he moved to London, Ian's work has grown to encompass other people's passion projects, too. Today, he creates still lifes of book collections, such as Horniman Anthropology.
Moving to study at University of the Arts London and, later, Wimbledon College of Art, he "began to make a connection with museum collections in study rooms." This painting is a personal response to the subject; an attempt to capture the spirit of the books and the person who collected them. "A lot of preparation goes into layout and composition," says Ian. He studied them at the Horniman Museum, the former home of the eponymous collector. "I made an appointment and discussed the collection. Historical anthropology and travel books are a large part, due to Frederick Horniman's occupation as a trader."
He made a handful of small drawings and took photos, spending a day handling the books. "My goal was to
experiment with colour and lighting, and capture a handful of options on camera. The challenge was the balance between foreground, background and bookstack detail."
Back in his studio, Horniman's Anthropology was worked on two days a week and completed in a month. "I work over various underpainting layers as I go," says Ian. "I begin with still life drawing and, using photographic reference, transfer the drawing to canvas. I like to map the work out in monochrome, sometimes with acrylic colours." He painted the background blend before adding each book in turn, working quickly with small rigger sign-writing brushes, wet-on-wet. "A mahl stick keeps my hands out of the paint and I even use it to paint lines. I like Old Holland oil paint neutral tint or sepia extra rather than black, usually."
And with his meticulous approach, Ian builds an image that connects us to the physical history of his subject – the painting is almost an invite to reach in and flick through the books' crumpled pages, just as their previous owner did. Horniman's Anthropology is available as a limited edition giclee print. www.ianrobinsonartist.com


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Hey guys, for anyone interested, here is an audio link for the Neo Geo panel hosted by myself and Billy Pitt (Supergun) last Sunday. Hope you guys enjoy, it was fun. Thanks to wyo for hosting.
Hey guys, for anyone interested, here is an audio link for the Neo Geo panel hosted by myself and Billy Pitt (Supergun) last Sunday. Hope you guys enjoy, it was fun. Thanks to wyo for hosting.
It was fun sitting around listening to you guys reminisce. Did you get a good turnout? All your painstaking research over the years is very much appreciated by fans. Geddon, I hope you've made a full recovery.
Really enjoyed the proto talk, as always. Billy always gives me hope for the future.
If you ever consider updating the master list again, consider fixing the typo in Irritating Max/Ultra Denryuu Iararabou (should be "Irairabou"). As a Japanese major it always bothered me a little, and I noticed a lot of sites copied the mistake over the years. Otherwise the master list is basically perfect. You could update some of the prototype games. But the 2004 version is also good for historic purposes.
Thanks so much Alec, means a lot. Great suggestion too for sure. Feeling better now too, thanks
This was great to listen to while walking the dogs this morning. Especially interesting to a latecomer like me, who wasn't around back then.
This podcast was really interesting, and the hour flew by.
Lots of great vignettes, reminded me of what it was like to be a gamer in the 90s.
Good listen. Although it was mentioned vaguely that the unreleased protos would be released eventually but there were no details given which was a bit disappointing.
EDIT: I just finished and the last question clarified things some.
Last edited by Mister Chief; 11-28-2017 at 12:59 AM.
Awesome, glad you guys enjoyed it.
Really enjoyed listening to this, its great to hear the stories from way back when and I especially liked the past and present information on Prototypes exciting stuff, would like to hear more of this kind of stuff if you guys ever get together for podcasts or something.
Enjoyed your talk. Thanks for recording and sharing it. Maybe next year you guys can focus on MVS stuff? I'm interested to hear about Neo Geo in the arcades back in the day, and it sounds like Billy has some knowledge there.
Sony PVM Club, Blast City Club, Egret II Club, Neo Candy Club
WTB: Neo Geo MVS-U4 or MVS-U4/29
I was there at Free Play Florida, but was holed up in the pinball tournament otherwise I'd have been at this. It was literally right across the hall. I did listen to this though, fun listen to hear how things were back in the day.
Nice little chat archive, nothing new if you were around, but interesting to hear about those kind of personal stories on those that took the plunge into aes when it was active. And on that note, good on the mom who was fine with you taking their credit card to put $1000 on it for games, especially back then, even if you could back it up from the piggy bank.
That was a fun listen. I greatly enjoyed it.
Awesome! I havd something to listen to at work today.
+1 for the great podcast. I am looking forward to the future projects mentioned during the discussion.
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