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The Future of Deep Brain Stimulation
No comments yetPosted in Wonders of the BrainAug 31, 2017
Ed Boyden is a professor at the Massachusett's Institute of Technology who leads the Synthetic Neurobiology group. He's credited with important contributions towards the revolutionary field of optogenetics. Essentially, it involves a bunch of molecular tools that make specific groups of neurons switch-on-and-offable simply by shining a light on them. This incredible innovation has given neuroscientists unprecedented level of precision in controlling the activity of different types of neuron in experiments trying to unpick the brain's mind-bogglingly complex circuitry.
It seems that he and his research team may well have done it again. They have developed another potentially incredibly powerful innovation that could fundamentally change how we approach Deep Brain Stimulation (DBS). This new approach is called Temporal Interference Stimulation (TIS) and the breakthrough it offers is enabling deep brain structures to stimulated without having to cut through the skull and actually insert electrodes into the brain.
The DBS approaches currently used in humans involve passing electrodes through holes in the skull all the way down to deep brain areas in order to deliver pulses of electrical stimulation at the desired location. This has become a relatively routine medical intervention that fundamentally improves quality of life for thousands of people suffering from a range of brain illnesses all over the world. It has proven effective in a variety of chronically-debilitating diseases including Parkinson's Disease, Major Depression and Obsessive Compulsive Disorder helping to circumvent common problems whereby patients either don't get any improvement from their medications, or do at first but then the drugs stop working after a period of time.
DBS therapy is most striking in people with Parkinson's patients. Gradual death of the dopamine neurons that play an important role in initiating voluntary movements is the root cause of Parkinson's disease. Dopamine-boosting agents often help with their movement difficulties but the benefits do not usually last forever. The invention of NICE-approved DBS therapy has been a lifesaver for many thousands of people. By applying an electrical current to either the thalamus, globus pallidus or subthalamic nuclei, limb movements can be controlled as normal. Their distinctive seemingly hesitant, shuffling walking style can be replaced with a normal, confident striding gait at the flick of a switch.
The surgically-implanted electrodes often yield remarkable improvements in their symptoms, but having to cut holes in people's skulls and physically implant wires in their brains is fraught with risks and potential complications. TIS, at some point in the future, could offer the same benefits but without the need to put any man-made objects inside the brain.
We've had technologies that are capable of influencing brain activity from the skull surface for many years. Both Transcranial Direct Current Stimulation (tcDCS), which sends electrical currents across the skull, and Transcranial Magnetic Stimulation (TMS), which produces transient magnetic fields that extend across the skull, are both able to influence brain activity without the need for invasive surgery. But tcDCS and TMS are unable to influence areas deep inside the brain with any precision, they can only modulate brain activity at the surface. With TIS, all that it set to change as the technology progresses from experiments with mice, through larger and larger mammals, until it is eventually (hopefully) proven to be safe and effective in humans.
As with all brilliant scientific solutions, TIS is elegant in its simplicity. A high frequency electrical current has no effect on brain tissue. At lower frequencies electrical currents can disrupt the usual flow of information in whatever brain tissue it is passed through. Here's the clever bit. By applying two different sources of high frequency electrical current, at carefully separated positions on the scalp surface, where the two currents overlap sufficiently to cause interference in a way that reduces the frequency of the combined electrical signal it's possible to alter how the brain tissue functions. Every other region that the electric currents pass through on the way down to the target location is unaffected – only where the beams cross.
The team's recent paper, published in the journal Cell (free to download!), describes how this technique was used to selectively stimulate the mouse hippocampus, deep inside the temporal lobes, from the top of the skull. While reaching down to the human basal ganglia from the skull surface is a much greater challenge – penetrating to a much greater depth, across a much thicker skull – this proof of principle makes the dream of deep brain stimulation without surgery seem a realistic prospect in the not too distant future.
In addition to these monthly blogs, you can follow me on Twitter (@drjacklewis) where I post articles on breakthroughs in brain science and related topics. I also do a fortnightly science podcast with the lovely Lliana Bird. I also present a TV series called Secrets of the Brain on Insight TV. You can watch series 1 on Sky channel 564 (It's on most nights!), or you can stream it here. Series 2 is out in Autumn 2017…
Do You Remember That Time…?
No comments yetPosted in Wonders of the BrainFeb 28, 2017
Timehop is a reminiscence app for those that don't already have Facebook. It pulls photos from your social media streams to remind you what you were up to a year ago, 5 years, 10 years ago etc. There's nothing quite like a photo to trigger memories of a certain period of life. Sometimes I wonder if I would even be able to recall a tiny fraction of my life's events in a world before photography. It's usually the case that if a life event is deemed worthy of being captured in a photograph, then seeing it again will encourage a positive frame of mind. Only yesterday I overheard a relevant discussion between a pair of colleagues in my local supermarket. One showed the other a photograph of a family trip to Jamaica on his smartphone and the other murmured: "I love looking at old photographs, it's just the best."
The damage that Alzheimer's disease does to the brain regions that support retrieval of autobiographical memories can eventually extinguish a person's very sense of self, more often than not, the abolition of recollections from early on in life doesn't occur until the end of the process. For most of our lives, from developing a sense of self in infancy, to ultimately losing it once and for all, our sense of who we are follows an arc that seems to be wholly dependent on the accumulation of most poignant memories, often revolving around novel and emotionally stimulating experiences. They are a reference point from which we get our sense of who we are. They are physically manifested in extra synaptic connections in neural circuitry distributed all across the brain, far beyond the hippocampus famed for it's involvement in the creation and retrieval of memories. This brain blog is about the cues that can trigger recollection of our life's key experiences that are so important in defining to ourselves who we are.
At first a newborn infant has no sense of self. At this stage, even the very senses it uses to understand the world around it have yet to develop to the point where reliable information can be gleaned regarding what's out there. The brain first must be exposed to a vast torrent of sensory experiences that help to shape and mature brain areas that crunch the information coming in through the various sensory systems during early brain development. The capacity to actively explore the environment further enhances these memories for our early experiences, until sufficient experimentation of cause and effect results, miraculously, at some point during the second year of life (usually between 15 and 24 months) in the classic signs of awareness of selfhood. Infants recognise that the reflection in a mirror is themselves, as evidenced by attempts to wipe off a coloured mark that might have been surreptitiously smeared on their cheek.
Our sense of self develops in childhood as we experience more and more significant, emotionally affecting life episodes, which are each logged away deep somewhere in the recesses of our mind. Foods and people we like and dislike. Places in which we experienced pleasures and pains. Circumstances associated with unpleasant emotions associated with hunger, cold and threats, others that predicted feelings of comfort, excitement and laughter. Life's surprises and first time encounters dominate those memories that are most easily brought to mind.
Once we look back on childhood from the perspective of a fully-grown adult some interesting quirks of memory start to become evident. First is that memories from our earliest years of life are wiped. This childhood amnesia manifests as a complete inability to recall much of what happened to us before the age of three or four. Perhaps the odd fleeting memory of one or two key events at the age of four at best, but nothing from the ages of 0-3 years old.
The sense of smell has an astonishing capacity to remind us of early childhood memories. This can be accounted for by the fact that, of all our senses, the olfactory system is the only one that plugs directly into the brain's cortex without first filtering through the thalamus. The thalamus is the brain's major junction box through which the senses of vision, hearing, touch and taste are required to interface before being shuttled on for further processing at various dedicated patches of the crinkly outer surface of brain tissue. There are two major sites at which the sense of smell is generated according to the different types of gaseous chemicals detected deep inside the nostrils by hundreds of different types of olfactory receptor. One is on the underside of the frontal cortex and another on the medial (inward-facing) temporal lobes. The temporal lobes also house the hippocampus (fundamental to the creation of new memories) and the amygdala (critical for the production of emotions) perhaps explaining why scents tend to produce a powerfully emotional sense of reminiscence, typically evoking memories from before the age of 10.
The reminiscence bump describes the observation that, further back than their most recent experiences, adults over the age of fifty are most likely to recall experiences from late adolescence and early adulthood (15-30 years old). Whether cues used to elicit important memories are pictures or individual words, the majority of autobiographical episodes that pop into our mind tend to come from this period of life. A period in which significant events mold our character and help to form our adult self.
Racing Brains
No comments yetPosted in Wonders of the BrainMay 9, 2016
I've been digging around in the scientific literature recently in search of research investigating racing drivers' brains. Having stumbled a handful of pretty incredible facts I thought I'd devote this month's blog to sharing these with you.
Over many thousand of hours of practice and experience the driver's brains become honed to perform the incredibly demanding cognitive task of getting round the track, lap after lap, as fast as human possible, without spinning out of control. This is much more physically demanding than most people imagine. For instance, the forces delivered through the steering wheel when travelling at up to 200 mph on a typical track can reach a magnitude equivalent to carrying 9 kg in each hand. Maintaining the intensely focused concentration required to deal with the stream of rapidly changing sensory information also requires razor sharp reflexes and amazingly fast reaction times. In fact, one study demonstrated that there is no overlap in the spread of reaction times between elite and amateur racing drivers (as measured by the Vienna Reaction Apparatus). In other words, the slowest reaction times for the elite drivers across the whole experiment were still faster than the best reaction times logged by the amateurs.
Another biological specialisation exhibited by the elite drivers is their capacity to produce adrenaline. Their adrenal glands are larger than the rest of us so that they can produce more of this vital performance-enhancing hormone under high pressure racing circumstances. Adrenaline increases blood flow to the brain, heart and skeletal muscles, inducing an elevated heart rate and ventilation, whilst narrowing the blood vessels that feed other organs like the digestive system. This improves reaction times and the strength of muscular contractions to enable fight or flight to take place; or both as is the case in racing drivers. This is not specific to racing drivers. Athletes from many different sports have been found to have an enlarged adrenal gland, something referred to in the literature as the Sports Adrenal Medulla.
A further study compared the release of adrenaline and noradrenaline (primary neurotransmitter of the sympathetic nervous system) in elite racing drivers as they cycled to exhaustion in a staged bike ride versus whilst racing their cars. They were found to produce double the quantity of adrenaline whilst racing, as measured via detection of metabolites in their urine. I found this finding particularly extraordinary. You might have imagined that exercising to exhaustion would be more demanding on the body, but it just goes to show how cognitively demanding racing is. Presumably the extra adrenaline is required to help the brain deal with cognitive demands.
Several studies have scanned the brains of elite racing drivers using fMRI revealing that there is relatively little activity across the cortical surface compared to amateur drivers. This is thought to reflect the fact that racing is simply less taxing for the elite drivers. Much more of the cognitive processing required to manoeuvre the car around a constantly changing terrain at great speed can be handled subconsciously, freeing up precious conscious resources for dealing with unexpected occurrences.
Their extensive training also seems to have led to some racing driving-specific brain specialisations as they appear to exhibit greater activation in the retrosplenial cortex. This area is known to be involved in creating a view-independent model of environment being navigated. In other words it enables them to build a picture of the whole track in their mind's eye so that they have an awareness of what to expect beyond the next turn. This skill is clearly vital to staying on the ideal racing line.
I recently pitted my own amateur racing skills against Christoffer – the official test driver of the Koenigsegg supercar – in an ultra-realistic simulator of Spain's famous Ascari race track. The real thing, which he drives on a daily basis, is capable of producing 1,400 brake horsepower! Putting that into context, that's two and a half times more powerful than a top of the range Ferrari! I don't think it will come as any surprise to hear that he smashed me out of the park.
In addition to these monthly blogs you can also follow me on Twitter for a daily download of the most interesting neuroscience research to hit the press. In addition to my first best-selling book Sort Your Brain Out, my second Mice Who Sing For Sex is now available to pre-order and tells the story of over a hundred weird and wonderful nuggets of research from full the length and breadth of scientific research.
The Iceman Cometh by Dr Jack
No comments yetPosted in Wonders of the BrainJan 31, 2016
Have you ever heard of the Iceman? He is a remarkable Dutchman who has developed what seems like genuine superpowers. His many accomplishments include hiking up Mount Kilimanjaro wearing just hiking boots and shorts, swimming underwater for over 50m in a frozen Finnish lake and running a marathon 200m north of the Arctic Circle. However the most impressive thing about this particular real-life superhuman is that far from claiming to be unique, instead he boasts that anyone can do it. In the process of taking steps to prove this to the doubters he has brought the Wim Hoff method under scientific scrutiny which has led directly to an amazing discovery – we really can control our immune systems!!
I choose to write about this now because on 1st Jan 2016 I had to shrug off my hangover to fly to Amsterdam. On the 2nd Jan 2016 I met up with a Professor of Immunology to discuss the latest published scientific studies on the Iceman and his disciples designed to test and ultimately explain the mechanisms though which their impressive abilities to withstand the pain of freezing cold temperatures might be achieved. Then on the morning of 3rd Jan 2016 I finally met Wim Hoff and by midday, after just an hour's training, I was neck deep in a cold lake in the middle of the Dutch countryside with 300 enthusiasts. Life can be strange sometimes.
What I learned over the course of these few illuminating days in the Netherlands at the beginning of the month is that the Wim Hoff technique essentially involves three key processes: hyperventilation, cold immersion and a meditative mind state. Better still, each stage actually feeds into the next in a scientifically plausible manner.
Hyperventilation – what is it good for?
When we think of hyperventilation most people focus on the fact that it will saturate the blood with oxygen thus enabling more energy to be released when performing some kind of physically or mentally demanding task. Of course by breathing in and out, deeply and rapidly, for prolonged periods of time (in my case 3 sets of 30 full inhalation/exhalation cycles) as well as increasing oxygen input it will also eliminate more of the major waste material of metabolism that is carbon dioxide. And this, it turns out, is the most important part of the equation when it comes to withstanding environmental temperatures that would usually be deemed to be painfully cold.
When carbon dioxide is dissolved in your blood it forms a weakly acidic solution called carbonic acid. So the more carbon dioxide in your blood the more acidic it is. Conversely by removing more and more of this carbon dioxide from solution you can consciously exert control over your blood's pH by making it increasingly alkaline. In fact, it turns out that a pro like Wim can shift his blood pH from 7.2 right up to a more alkaline 7.85. Now that might not sound like a huge difference, but bearing in mind that on a scale that runs from 1 (extremely acidic) to 14 (extremely alkaline) this make 7.2 more or less bang on neutral and 7.85 is getting into the realms of weakly alkaline.
Alkaline blood – so what?
So what happens if you make your blood weakly alkaline through a few bouts of hyperventilation. I'll give you a clue, why would women in the process of giving birth to a child instinctively hyperventilate? Pain relief. You see what Wim stumbled upon as he was experimenting with different techniques to try and find the peace of mind he sought during the years after his wife died in 1995 leaving him to raise 4 children single-handedly was that by making your blood every so slightly alkaline you render pain receptors inoperable.
There is a special "trimer" protein inside your skin's nociceptors – the specialised receptors embedded in your skin that send electrical messages to the brain that end up being perceived as painful whenever a potentially damaging stimulus (like extreme cold) is detected in the environment. Trimers are so-called because they are formed from three separate strings of amino acids that wrap around each other to form a complex structure with a very specific function – signalling pain. But in the presence of slightly alkaline blood these three parts separate rendering the pain receptors unable to send any signals. Therefore the invigorating cold can be experienced in the absence of an associated perception of pain! So simple, but so clever.
How Cold Immersion begets a Meditative State
As I discovered on that cool day in early January, once you've got your blood alkalinity up through hyperventilation you can immerse yourself in cold water without feeling any pain. You do feel the cold, just with the aversive component of this experience switched off. And it was this experience of cold without pain that helped Wim to focus his mind not on the horrors of the past, not on the worrying aspects of the future, but to be centred entirely on the present. The exhilarating feeling of having the cold pressing in from all sides whilst in a state of undress. Getting into a meditative state through cold immersion was the only technique that reliably helped him to stay "in the moment" sufficiently to achieve the peace of mind he was looking for.
Wim Hoff is a lively character. Sitting still in peace and quiet is simply not his style. He is almost perpetually in motion. Any spare moment he will take the opportunity to do some chin ups, balance his body on his elbow like some kind of breakdance fiend or simply do the splits. And this is a part of the overall process of becoming the Iceman. In addition to the cytokines released in response to regular cold exposure, Wim's body is also thought to release myokines – messenger proteins released from active muscles. The combination of these influences means that his DNA is being read differently from the rest of us more sedentary modern humans.
Hyper Life versus the Easy Life
It's almost as if Wim has managed to trick his body into reverting to caveman mode. There is scientific evidence to support the hypothesis that after decades of leading a hyperactive, hyperventilated life including daily exposure to extreme conditions, every single one of his cells has started to read off a different set of genes to the rest of us. I've never met anyone with more energy, yet he doesn't eat breakfast or lunch, just one (presumably huge) meal in the early evening, which is probably how our ancient ancestors dined having spent the whole day hunting and foraging for the evening meal. We modern men and women on the other hand spend our days ensconced in centrally heated / air conditioned homes and workplaces, spending the vast proportion of our days sedentary with packed fridges just a few steps away and so our bodies switch on genes that adequately support this easy life.
A New Perspective
Many diseases that used to kill off our ancestors in huge numbers are now firmly under control thanks to the marvels of modern medicine. Of those which still place our lives and quality of life in peril, several involve and element of over-activity in our immune systems; so-called autoimmune diseases like rheumatoid arthritis and multiple sclerosis, to name but few. Wim's brave auto-experimentation, combined with his profound desire to bring his discoveries firmly under the scrutiny of science have enabled the revelation that he has incredible control over his immune system. He (and volunteers who have followed his approach under clinical conditions) can bring down the levels of pro-inflammatory IL-6 and IL-8, whilst boosting levels of anti-inflammatory IL-10 to the point where he doesn't get sick when exposed to bacterial endotoxins. Whilst control subjects respond to the toxic injection by shivering feverishly within about half an hour, the Iceman sits there unperturbed by the nasties in his bloodstream. The potential to learn his technique in order to reduce overactive immune systems and thereby defeating various autoimmune diseases is bringing hope to many whom had previously lost faith in prospect of a cure.
In addition to these monthly brain blogs, you can follow me on Twitter (@drjacklewis) for daily updates on breakthroughs in neuroscience, buy my first book Sort Your Brain Out at all good bookshops and see me back on your TV's very soon in two brand new series on insight.tv and Red Bull TV!
Bionic Brain Adaptations by Dr Jack Lewis
No comments yetPosted in Wonders of the BrainNov 30, 2015
First I met a bona fide bionic man in Cambridge – that got me thinking about an essay I wrote whilst in my undergraduate neuroscience days. It explained, in great molecular detail, the obstacles that would have to be overcome for a robotic limb to ever adequately replace the functional repertoire of a severed one. In other words I described what it would take to do a "Luke Skywalker" (for those who actively avoid Star Wars: Luke is the hero who get his arm chopped off in a light sabre battle only to have an operation that replaces the severed limb with a fully-functional robotic one that he controls as effortlessly as the original).
Second I flew to Kyoto – to interview the Godfather of Androids, a man who has created some of the most sophisticated human-like robots in the world. Over ten days of filming I must have come face-to-face with over a dozen robots. Each time I thought back to something that happened, totally spontaneously, during a game of Jenga with Nigel Ackland – my real life Luke Skywalker.
Finally, Nigel performed a manouevre with his robotic arm that no human could with a mortal one. This event brought to mind a classic series of Japanese neurophysiology experiments from the lab of Professor Iriki. These studies expanded our understanding of how brains keep track of the space around us. In particular, how brains distinguish between parts of the environment that can be influenced with a extended arm (plus any tool that provides an extension), and parts that cannot (NB see in particular the original observations from 1996).
Consequently, this month's brain blog is dedicated to a combination of…
Robotic Technology, Human Determination & Neuroplasticity
The parietal cortex of the primate brain (including the human primate) is responsible for, among several other important functions, our awareness of space. For example, damage to the patch of brain tissue that resides where the parietal lobe borders its temporal and occipital lobe neighbours can lead to neglect if it occurs on the right side of the head (See the images in this free classic paper on neglect if you want to see exactly where in the brain this is) – resulting in the person's awareness of the left side of everything being highly compromised. Give someone with neglect a piece of paper with circles drawn all over it, asking them to place a mark at the centre of each, they only mark circles on the right side of the page. Ask them to draw a clock face and they will not draw the numbers on the left side (i.e. having successfully drawn a circle and the hours from 12 to 6 on the right hand side, they'll typically omit the hours of 7 – 8 – 9 – 10 and 11 because they lack awareness of what should be on the left side of a clock face). They will only eat food from the right side of their plate. They will often even only shave the right side of their face, dress the right side of their body. Their awareness of "leftness" has been fundamentally compromised. Such is the importance of the parietal cortex to our awareness of space.
Towards the end of the 90's and early 00's researchers working with Japanese macaques trained to reach for food rewards observed that certain neurons would become activated if the treat was placed within arm's reach. If the primates were provided with a croupier's rake (usually used in casinos to collect up chips on gambling tables) then neurons representing nearby space that was previously out of reach would become activated once they gained experience using this simple tool to drag the food rewards towards them. The researchers even took it a step further by providing two rakes, one with a short handle and one with a long handle. Neurons representing space out of reach with the short handled rake became recruited into the "network of reachable space" when the macaques figured out they could use the short rake to pull the long rake closer and then use this to drag the treat from the opposite side of the table. Keep this in mind as you read the following account of bionic brain adaptation.
Bionic Brain Adaptation?
Nigel Ackland is a real life bionic man since a nasty industrial accident left his arm mangled and several subsequent botched surgeries led to his decision to have his right arm amputated from the elbow down. Shortly after this operation, he started to develop pain in his phantom limb. His NHS-issued "pincer" enabled him to gain some additional dexterity, but it did little to diminish the phantom sensation of his fingers and wrist locked into an extremely uncomfortable position. However once he started using a cutting-edge bionic arm, equipped with various pre-programmed five fingered hand movements operated via neuronal signals passing from his brain to the muscles at the end of his arm stump, not only did the phantom limb pain start getting better, but the phantom limb started extending gradually from his stump into the hand and fingers of his bionic arm.
Whilst playing Jenga with him for my new series Nigel did something quite remarkable, triggering the memory of those Japanese macaques. Reaching with his bionic arm to grab an awkwardly positioned brick, from his side of the table he could only present the back of his hand to the block he was after. Unlike the rest of us mere mortals Nigel can rotate the hand of his bionic arm at the wrist by 360 degrees. To reach the brick in question he simply rotated his hand 180 degrees to face the other way, and then grabbed the block he was after with his bionic thumb, fore- and middle fingers in the usual way. It immediately occurred to me that people with bionic limbs – who can do things a normal human limb can not – may be awakening neurons in their parietal cortex that represent areas of space that have never before been recruited into the "network of reachable space" in the history of our species. Now that is very cool.
In addition to these monthly brain blogs, you can subscribe to my weekly science podcast (via itunes, via libsyn) and follow me on Twitter (@drjacklewis) for a daily dose of news articles describing the latest breakthroughs in brain science.
What Does a Human Brain Really Look Like?
No comments yetPosted in Wonders of the BrainNov 26, 2013
I saw my first real life human brain as a neuroscience undergraduate at the University of Nottingham. My neuroanatomy professor dipped his gloved hands into a white plastic bucket from which pungent fumes had been emanating since we entered the dissection lab. Tugging on a piece of string looped around the corpus callosum (the thick bundle of fibres that connects left and right hemispheres) he lifted up an off-white brain into view. There were literally gasps of astonishment from the assembled teens. To witness the seat of all human perception, cognition and emotion in the flesh is quite an awesome experience. There was a second bucket that contained a far more gruesome anatomical specimen. The right half of an old man's entire head and neck! His face was perfectly preserved, right down to the stubble on his chin and the calm expression on his face. But flipping the specimen over revealed the inner face of his right brain hemisphere, the midline of his thalamus, brain stem and uppermost part of his spinal cord. Although this grotesque/incredible sight sent several of my colleagues bolting out of the room to visit the bathroom I was spellbound – this was precisely what I had hoped for when I opted to do a B.Sc. in neuroscience.
I'll never forget those two brains. I was thrilled to take the opportunity to hold and examine them, scrutinising the anatomical landmarks that I'd studied only in textbooks for so long. However the appearance of these brains was totally misleading. Soon after the donor had been declared dead all of the blood would had been flushed out of the brain's blood vessels and then washed out with a preservative – the overpowering nasal insult that is formalin. I knew this was the procedure but I must admit to not realising how much the process transforms the appearance of this "fixed" brain in comparison to a fresh one.
For many years the memory of handling those heavy, pallid brains, with texture not dissimilar to the "bouncy ball" toys of childhood, fundamentally influenced how I imagined the living brains of the several dozen people I scanned during my Ph.D. research using MRI. Indeed, the fact that structural MRI images of the brains in question are rendered in black and white only compounded this false impression. I spent many cumulative hours looking at such misleadingly coloured brains. To double check that my subjects were keeping still as instructed during the scan. To ensure that the realignment/morphing stage of preprocessing hadn't introduced any glitches. To establish in which anatomical areas the significantly activated voxels might have resided. Ultimately the idea of brains as a greyscale entity was firmly embedded.
It wasn't until Channel 4 decided to televise a live autopsy courtesy of Dr Death (or Professor Von Hagens as he is formally known) that I realised my mistake. Unlike a medical school autopsy, which usually use bodies that have been preserved by replacing bodily fluids with formaldehyde, this one was going to be using a fresh cadaver. I was literally gobsmacked when he sawed open the roof of the skull and a wobbly, pale pink, real, fresh human brain flopped out into his hands. It was more the texture of blancmange than firm rubber.
The human brain is a truly amazing organ. Both in life and in death. If you're curious, take a look at the footage below of a real, unpreserved, human brain fresh out of the skull, courtesy of the University of Utah.
Infant Brain Development by Dr Jack Lewis
6 Comments »Posted in Wonders of the BrainApr 14, 2011
In the womb, brain development occurs at a startling pace. Seven weeks after conception the nervous system is sufficiently developed for the foetus to translate detection of gentle brushing of the nose and lips into a reflexive movement of its head away from the stimulus. Just ten weeks into gestation, i.e. towards the end of the first trimester, the first coordinated finger movements that constitute the grasp reflex are already kicking into action in response to stroking of the palm.
At birth, all our different senses are somewhat intermingled, only differentiating out into distinct, separate senses through experience. Infants learn to distinguish sights from sounds, smells, tastes and touch by interacting with the environment. Synaesthesia – where stimulation of one sense results in perceptions in another (e.g. coloured sound) – is thought to result from incomplete separation of the senses.
Babies are not born with the ability to perceive the outside world as adults do. Right from birth a baby will pull different faces in response to salt, sour, bitter and salty tastes, yet most of the other senses are enormously underdeveloped. The senses must be honed interactively with the environment during early life. The more varied the experiences the more sophisticated their sensory perceptions will become, as will their ability to make sense of events encountered in the outside world, and ultimately the manner in which they engage with their environment.
When a baby opens its eyes for the first time a critical period begins in which the neuronal wiring of the visual brain is gradually moulded to make sense of all that light. A newborn baby's visual acuity is 1/30 that of an adult – it sees outlines but no detail. At 7 days old, babies show a preference for curved over straight lines, but cannot make out a face until the fourth week.
Hearing, however, is a different matter. Sounds from the outside world can reach a baby's ear whilst still in the womb allowing the auditory sense to be honed whilst still inside the womb. The theme tune to the Australian soap opera "Neighbours" was actually instrumental in revealing that babies can begin to hear and recognise specific sounds during the third trimester of pregnancy! An observant mother noticed that her foetus's behaviour consistently changed as soon as the vocals kicked in every weekday.
At 3 weeks of age, babies smile in response to the sound of their mother's voice, whilst not until 6 weeks do they smile in response to the sight of a friendly human face.
The skin is the human body's largest organ. It contains many types of touch receptors, each cleverly designed to create various different sensations. Merkel cells, for instance, are sensitive to soft, delicate caresses. These are particularly abundant in the lips, tongue and fingertips, enabling extraction of texture, size and shape information.
Two months after birth, infant brains see objects as targets to be looked at or reached for (they usually don't successfully hit the target until 4 months), whilst they respond to humans socially – with smiles, vocalisation and, of critical importance, efforts to imitate their actions.
In early infancy the visual brain is developed enough to define the edges of an object, providing the motor system with a target for the hand to reach for. At 2 months an infant typically uses one hand to investigate the object, usually bringing it to the mouth. By 4 months the infant can use two hands, one to hold it and the other to extract shape and texture information.
By the age of 6 months if the parent shakes an object, the infant will tend to shake it too. If the parent bangs an object on the table, the infant will tend to copy this. Thus even at this young age the example set by the parent or caregiver is vital for the successful acquisition of skills.
Development of an infant's senses accelerates when it has acquired the ability to crawl around and explore the world by touch. Various institutions provide parents with a place to go where their infants and children can engage with and explore a rich variety of stimuli in a safe environment. Most of us will have been taken to play school, crèche or just the playground as kids, overtly to keep us occupied and tire us out, but implicitly so that we could explore a range of exciting sensory stimulations and ultimately learn to use and develop our senses and ability to make sense of "how the world works". Such offerings have become gradually more sophisticated up until the point where institutions like The Little Gym provide not only the setting, but also trained guidance to parents and children alike that bears in mind the developmental milestones that kids should pass through at different life stages.
Activities at The Little Gym are constructed for each age group in light of current knowldege gleaned from advances in developmental neuroscience and conducted in a non-competitive manner to ensure that children's confidence in using their bodies is incrementally boosted after every session. I've visited The Little Gym in Chiswick, London and was very impressed to see how much thought had gone into tailoring activities to match the specific developmental level of each age group. Apparently they have no trouble convincing parents of the benefits of The Little Gym approach once they have got them to attend a session. When new parents compare their own children's movements and sensory awareness to kids who've been attending The Little Gym for even just a few months, the advantages of having trainers directing the "play" activities according to a sound knowledge of child developmental trajectories are often abundantly obvious. One reason it is really good for kids to hit their developmental milestones as soon as they are able is that it creates a "can do" attitude that fosters positive engagement with the environment that gives them self-belief. And if you can instil a real sense of self-belief in a child then this will really help to shepherd themselves through the intellectual, social and emotional turmoil that they will almost inevitably encounter during adolescence.
Don't forget you can follow Dr Jack's daily #braintweets at: www.twitter.com/DrJackLewis
Crash course in brain anatomy anyone?
17 Comments »Posted in Wonders of the BrainMar 19, 2010
The terminology associated with brain anatomy can seem intimidating to the uninitiated, but really there's no need to be intimidated.
A pair of cartoon rodents (Pinky and the Brain) managed to get their heads around it and so will you.
Here's their quick guided tour to the different parts of the human brain.
It's a shame they don't really mention the role of each area they name.
I guess that would have made making the lyrics rhyme even more complicated!
To supplement their guide to neuroanatomy (what bit is where) I've given a quick overview of what each bit does in the order they're covered in the cartoon:
1) Neocortex – the whole large sheet of brain cells on the brain's outer surface, folded up into the skull giving it the appearance of a walnut.
2) Frontal lobe – the region of the neocortex at the front of the brain, behind the forehead, which is much larger in humans than our monkey cousins and enables us to do all those complex functions that other primates cannot.
3) Brainstem – the part of the brain that ninja assasins aim for with their deadly chop where neck meets skull, it is involved in coordinating all the vital bodily functions that keep us alive e.g. breathing and heart rates.
4) Hippocampus – key brain area at the core of the temporal lobes (which run horizontally down the sides of the head from the temple to behind the ears) which is heavily involved in not just creating, but also retrieving memories. It also creates new brain cells in response to exercise!
5) Neural node – erm, I think they just needed something sciency sounding to rhyme with the other lines. The image THE BRAIN enlarges with the magnifying glass is a single brain cell complete with nucleus (which contains all the DNA) at it's centre, the dendrites (receiving information from other brain cells) plus a single axon (along which electrical messages are sent to other brain cells).
6) Right hemisphere – the left and right sides of the neocortex are separated by a fluid filled gap yet are connected by a massive bundle of neuronal connections called the corpus callosum that bridge the gap enabling left and right sides to send and receive information between them.
7) Pons – All of the commands travelling from parts of the neocortex involved in motor control (i.e. body movements) pass through the pons which sits on top of the brainstem which is at the very top of the spinal cord through which the brain controls all the muscles of the body.
8) Cortex visual, usually referred to as the visual cortex, sits right at the back of the brain. So the eyes quite literally detect light striking the retina, at the back of the eyeball, and send this information all the way to the back of the brain before we can see anything!
9) Pineal, usually referred to as the pineal gland, is about the size of a grain of rice and produces melatonin which regulates the sleep/wake cycle. Daylight in the morning switches off melatonin production to make us feel awake, switching production back on in the evening so we can sleep.
10) Cerebellum left and right, critical for balance and co-ordinated muscle contractions important for effective speech, walking, running, swimming and all sporting activities etc.
11) Synapse – the gap between one neuron and the next. Electrical signals arriving at the end of one neuron releases tiny packets of brain chemicals that travel across the synapse, bind with special receptors on the other neuron to trigger or inhibit electrical signals its own electrical messages.
12) Hypothalamus – the most important site of hormone production and release that powerfully regulates innumerable body and brain functions.
13) Striate, a. k. a. striatum – enormously important subcortical brain area (deep in the brain not on the surface of the neocortex) involved in reward and motivation, planning and modulation of movements, named thus due to its stripy appearance.
14) Axon fibres – as mentioned before this is the part of the brain cell that sends electrical messages to other brain cells.
15) Matter grey, usually know as the famous Grey Matter. This is darker than the white matter as this is where all the synapses and cell bodies are. So it is in the grey matter that all the computational power of the brain is unleashed.
16) Central tegmental pathway: the tegmentum is a part of the midbrain – which lies between the striatum and the brain stem. Activation of the ventral tegmental area, i.e. the "belly" of the tegmentum, causes the feelings of intense pleasure when people eat, drink, have sex or take drugs.
17) Temporal lobe – the upper surface of the temporal lobes is the part of the brain we hear with.
18) White core matter, usually referred to as White Matter, consists of millions and millions of axonal fibres that ferrying electrical signals from one brain area to the next.
19) Forebrain – we've done that already
20) Skull – the bone in which our brain is cradled
21) Central fissure – the name for the fluid filled gap described earlier which separates the left and right hemispheres
22) Cord spinal, usually known as the spinal cord, through which axons pass sending messages from brain to body and body to brain.
23) Parietal – one of the lobes of the neocortex – involved in spatial awareness, focusing attention and mathematical calculations.
24) Pia mater – is the innermost of the three brain sacks (or meninges) which cushion and protect the brain.
25) Meningeal vein – blood vessels taking waste materials away from the outer parts of the neocortex.
26) Medulla oblongata – lower part of the brain stem, also involved in triggering reflexes like vomiting, sneezing, coughing etc.
27) Lobe limbic – usually known as limbic system, deep inside brain beneath the temporal lobes, involved in generating emotions.
28) Microelectrodes – there is not a microelectrode in sight so just ignore that lyric!
In addition to these monthly brain posts you can follow me on Twitter for my thrice daily #braintweet.


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The Harris Teeter on Hilton Head Island's south end will reopen today after a four-month project to move into larger quarters in the Park Plaza shopping center.
The new store, which was in early stages of construction when the adjacent, original Harris Teeter closed in late November, will host a ribbon-cutting ceremony at 5 p.m. at 33 Office Park Road.
At more than 50,000 square feet, the new Harris Teeter is about 50 percent larger than its former home. The old store was demolished and converted into parking space.
The store will feature several new amenities, including a pharmacy, salad bar and a misting station for bikers and walkers.
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Some new features -- such as motion-detection lighting and doors on medium-temperature cases in the store's fish and butcher's markets -- are designed to conserve energy.
The former Harris Teeter was built in 1988, and it was too small to offer the variety of products and amenities available at the chain's more recently built locations, according to company spokeswoman Catherine Reuhl.
By opening in early April, the store can take advantage of the spike in visitors to Hilton Head's south end during Easter weekend and the RBC Heritage.
All of the old store's 50 former employees were invited to return to their jobs, and many of them began restocking shelves in mid-March. The store will have 130 employees, according to Reuhl.
The store will be open from 5:30 p.m. to midnight today, 8 a.m. to midnight Wednesday, and commence regular operating hours of 7 a.m. to midnight Thursday.
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subset: commoncrawl


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Rajasthan, India
Situated on the banks of a picturesque dam in rural Nimaj, between Jaipur and Jodhpur, Chhatra Sagar is a remote, luxury tented camp offering travellers a romantic and unforgettable experience. Run by the local ruling family, the hospitality at this luxury-tented camp is warm and friendly and the service is impeccable. Children are welcome but there are no specific facilities, although babysitting is available.
13 spacious and lavish tents overlook the lake and come with private verandahs offering spectacular views. Each tent features a chic and colourful interior, comfortable beds and bathrooms with hot and cold water. Two of the tents are set atop a hill providing complete privacy and 360-degree views.
Dining at Chhatra Sagar is a gastronomic experience. Enjoy a sumptuous feast of traditional Indian and Rajasthani dishes served in a enchanting setting overlooking the lake or around the campfire under the stars.
Visit local farms and villages to gain an insight into rural Rajasthani lifestyle, go on a birdwatching tour or on a jeep safari through the beautiful terrain. You can also go boating on the lake.
Home to a myriad of wildlife, Chhatra Sagar is a nature-lovers paradise. Relax in the enchanting surroundings, soak up the sun by the lake or walk up the nearby hill and enjoy a romantic sundowner as the sun sets.
Chhatra Sagar is closed from April to September.
Chhatra Sagar Information
- Location:Nimaj, 6 hour drive from New Delhi International Airport.
- Accommodation:13 Luxury Tents
- Activities:Visit local rural villages and farms, tours for birdwatching.
- Facilities:En suite tents, restaurant.
- Weather:The wet season is from April to mid October, the best time to visit is during October to April
- Children:Welcome although no specific facilities. Babysitting is available.


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The /r/forbiddensnacks of Azeroth I would fell for.
He hunts them obviously. Heretics are usually the first to push the blame to others you know!
Ye did well, champion. I can feel Azeroth recoverin' her strength, thanks tae ye.
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/r/wow recommends using old reddit. New Reddit does not support the same level of customisation as old reddit, and we do not currently support link or user flair on new reddit.
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Isn't this one cute, even with its waste canvas in? (Waste canvas is, by the way, magical! I'd never used it before and now I'm seeing cross-stitches all over everything in my house!)
After my cats' complete and utter (and undeterable) obsession with my polar bear, I decided that it was a bad idea (for me -- I don't think there is a single thing wrong with the patterns) to leave the bottom open, as instructed, and so I cut a little ellipse out of some leftover felt and made a faux-ribbed cuff to close the opening, while still leaving the bottom of the mitten "open" (the extra piece of felt made the bottom 3D, rather than just blanket stitching it all closed). Maybe this will keep it all in one piece after the cats find my hiding spot (on the wall) and play football with the mitten.
And, to close, a less dismally dark photo of my polar bear, complete with tiny scarf. He he!


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Ned Davis Research: Maximum Overweight EquitiesPublished April 8th, 2010 in Technical Analysis
Recently Tim Hayes, the Chief Investment Strategist at Ned Davis Research, sat down for an interview with Ron Insana (sitting in for Pimm Fox). In the interview Hayes outlines NDR's outlook for the equity market, bond market, commodities and why they continue to be extremely bullish.
In summary, NDR continues to believe that we are in a cyclical bull market that is intact and is recommending to their clients to stay long because they see no real evidence of a change in trend. For more details, check out my notes (or listen to the interview below):
- vast number of stocks making new 52 week highs
- not just US markets but around the world
- it is a broad based global bull market
- NDR classifies this as a cyclical bull market within a secular bear market
- a cyclical bull market can go on to 1-2 years - we're 1 year into it
- from a long term perspective, we are not yet out of the woods
- not expecting a deep correction
- more likely a drawn out shallow correction in the 10-15% range
- looking for a moderate decline within a continuing cyclical bull market
- so few signs of divergence in the market to signal the end of the trend
- risk appetite is returning, tech stocks are doing well, small caps perform well, emerging markets, financials are strong as well
- not seeing the type of divergence that would signal a major drop
- first divergence monitor is interest rates - if bond yields break up to 4-4.25% or higher
- if yield curves flatten from their current steepness right now
- if small caps or consumer discretionary weaken
- these type of divergences would signal a turn
- non-participation of average investor is more evidence of secular bear market
- some money market outflows have been increasing
- but still a lot of cash still on the sidelines
- we're probably see a "capitulation" but won't see the kind of participation that came with a secular bull market
- won't see people come back in the way that they did but their return would signal another cyclical decline within this larger secular bear market
- while performance in past decade was abysmal, didn't get us down to low levels of valuation
- no single digit PE ratios for example that we saw in the 1970's
- no washout that took us to the other extreme (cheap valuation)
- runaway inflation a distinct possibility due to massive expansion of Fed balance sheet
- commodities telling us inflation in the pipeline
- we could see a period of inflation, maybe next year, causing rates up
- that could send the equity markets lower in 2011
- gold and commodities are starting to gain traction
- "China driven commodity demand theme" = secular commodities bull market
- gold is just about half way from its previous top (inflation adj.) so still upside left
- NDR is maximum overweight in equities since June 2009
- NDR switched from market weight to overweight in April 2009
- want to stay exposed as long as we have such broad participation
- NDR is also overweight emerging markets
- correlation between emerging markets and commodities
- the expected correction could therefore take both of them down
- NDR sector outlook: overweight energy, materials, consumer discretionary, technology
- interest rates not a big worries - 10 year T-bill and S&P 500 have had positive correlation for past year
- only a big move would scare Wall St.
- a 4.25% may deliver a correction but…
- a move above 5.25% would cause a major break
Timothy Hayes of Ned Davis Research:
Press play and let it buffer, then jump ahead to the 12 minute mark to listen to the complete interview:
Enjoyed this? Don't miss the next one, grab the feed or
3 Responses to "Ned Davis Research: Maximum Overweight Equities"
Apr 9th, 2010 at 4:55 am
Also BCA Research, in their asset allocation quant model, are 91% overweight equities in April and zero percent bond. Maybe they will be right again, as always. But this time I am bearish toward mid June and I will uy some put today …
Apr 10th, 2010 at 6:14 pm
Thanks for posting this!
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Hello all!....I've been trying to plan out my card creations of late, to coincide with upcoming birthdays and although I'm covering most, l needed a young teen boy card and had nothing l felt was suitable. So l inked up the "Simply Stars" set in some bold colours and angle cut some layers, added in some silver foil cardstock and went to town with some SU star punches...Super quick!
The greeting is from the Banners bundle and l love the big bold font, it's perfect for this style of card, not too fussy for a young teen!


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January 20, 2016 07:30:21
Posted By Hastamorir Artists Society
"Companies whose global profits total $125bn (£86.7bn) cannot credibly claim that they are unable to check where key minerals in their productions come from"
In a report into cobalt mining in the Democratic Republic of the Congo, it found children as young as seven working in dangerous conditions. Cobalt is a a vital component of lithium-ion batteries.
The firms said that they had a zero tolerance policy towards child labour.
The DRC produces at least 50% of the world's cobalt. Miners working in the area face long-term health problems and the risk of fatal accidents, according to Amnesty.
It claimed that at least 80 miners had died underground in southern DRC between September 2014 and December 2015.
It also collected the testimonies of children who allegedly work in the mines.
Paul, a 14-year-old orphan, started mining when he was 12 and told researchers: "I would spend 24 hours down in the tunnels. I arrived in the morning and would leave the following morning ... I had to relieve myself down in the tunnels … My foster mother planned to send me to school, but my foster father was against it, he exploited me by making me work in the mine."
UNICEF estimates that there are approximately 40,000 children working in mines across southern DRC.
In response to the report, Apple said: "Underage labour is never tolerated in our supply chain and we are proud to have led the industry in pioneering new safeguards."
It said that it conducts rigorous audits on its supply chain and any supplier found hiring underage workers is forced to:fund the worker's safe return home, finance the worker's education at a school chosen by the worker or his/her family, continue to pay the worker's wages, offer him or her a job when he or she reaches legal age to work.
On cobalt specifically it added: "We are currently evaluating dozens of different materials, including cobalt, in order to identify labour and environmental risks as well as opportunities for Apple to bring about effective, scalable and sustainable change."
Samsung said that it had a "zero tolerance policy" towards child labour and that, it too, conducted regular and rigorous audits of its supply chain.
"If a violation of child labour is found, contracts with suppliers who use child labour will be immediately terminated," it said.
Sony commented: "We are working with the suppliers to address issues related to human rights and labour conditions at the production sites, as well as in the procurement of minerals and other raw materials."
By Jane Wakefield. Technology reporter 19 January 2016


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The Master said: 'But the sea, a plain, a colonnade, and a karmelith rank neither as public nor as private ground.' But is a plain neither private nor public ground? Surely we learnt: A plain: in summer it is private ground in respect to the Sabbath and public ground in respect to uncleanness;12 in winter it is private ground in both respects!13 — Said 'Ulla: After all it is a karmelith; yet why is it called private ground? Because it is not public ground.14 R. Ashi said: E.g., when it has barriers,1 and [this is] in accordance with the following dictum of 'Ulla in R. Johanan's name: An enclosure more than two se'ahs [in area]2 which is not enclosed in attachment to a dwelling place,3 even if it is a kor or two kor [in area],4 if one throws [an article] therein [from public ground] he is liable. What is the reason? It is a partitioned area, but it lacks inhabitants.5 Now, as for R. Ashi, it is well that he does not explain it as 'Ulla;6 but why does 'Ulla not explain it in accordance with his own dictum? — He answers you: if it has barriers, is it called a plain: [surely] it is an enclosure! And R. Ashi?7 — 'Private ground' is taught.8This dispute between Rav Ashi and Ulla can be classified as a dispute between Bavli and Yerushalmi. Rav Ashi is the redactor of Bavli, while Ulla is an Amora from Eretz Yisrael. Indeed, if we turn to Yerushalmi, we will find that it is in line with Ulla. In Yerushalmi Berachot 5b (with the commentary of the always excellent Yedid Nefesh embedded):
ים ובקעה ואיסטווה מקום שיושבים הסוחרים לפני החנות ואסקופה מפתן שאצל הפתח, ורק אם רחב ד' טפחים, ואם אינו רחב הוה מקום פטור וכרמלית, אינן לא רשות הרבים ולא רשות היחיד. ואין נושאין ונותנין מטלטלים בהן מדרבנן ואם נשא ונתן בהן פטור. אמר רב יוסף אף אנן תנינן כולהן. ים, דתנינן תמן להלן פרק יא הזורק בים ארבע אמות פטור. לא סוף דבר לא רק אם זרק ד' אמות בים, אלא אפי' זורק בכל הים פטור לפי שכל הים נקרא כרמלית. בקעה, דתנינן טהרות פרק ו הבקעה, בימות החמה שאין בה זרעים רשות היחיד לשבת כי אין רבים מהלכים שם, לפי שאנשים רגילים ללכת במסילה ורשות הרבים לטומאה לעניין שספיקו טהור. ובימות הגשמים, רשות היחיד לכאן ולכאן כך היא הגירסה. כי השדה זרועה ואין נכנסים שם כלל. אם אומר את וכשאתה אומר שבימות הגשמים שדה זו רשות היחיד לכאן ולכאן, לא תהא טעונה הקפה כלי בהמה אם חנו שם איך צורך להקיף את המקום כדי שיוכלו לטלטל בתוכה דתנינן עירובין פרק א, שיירה שחנתה בבקעה הקיפוה כלי בהמה, מטלטלין בתוכה ואם רשות היחיד היא מדוע אמרו להקיף? אלא כרמלית היא, ומה שאמר רה"י הכוונה שאינה רה"ר.That is, in analyzing the very same brayta as Bavli about the sea, plain, collonade, and karmelit, the Yerushalmi notes that it classifies it as non-reshut hayachid. And so it cites that other brayta about the plain (valley) in rainy vs. sunny season, where it is classified as reshut hayachid; and it concludes that it is not precisely reshut hayachid. Where Rav Ashi (=Bavli) would say no, it is a reshut hayachid, and we are dealing with where it has walls, the Yerushalmi says, similar to Ulla, that it could not be so, because otherwise we would not require an enclosure to be able to carry within it.
What is a karmelit, though? It appears as both the name of the class: karmelit; and as an item within the list of things which are karmelit. This is what prompts the following Bavli:
'And a karmelith.' Are then all these [sea, plain and colonnade] too not karmelith? — When R. Dimi came,9 he said in the name of R. Johanan: This is necessary only in respect of a corner near a street:10 though the masses sometimes press and overflow therein,11 yet since it is inconvenient for [general] use, it ranks as a karmelith.I would adopt a slightly different approach. Something is certainly off if it is the class name and an item name, and pashut peshat in the brayta is not that it is listed merely to include an otherwise unmentioned item. If this were indeed so, then Tosafot's question would indeed be a strong question. Tosafot ask why they did not include tzidei reshut harabim. And Tosafot gives a good answer, but still, it is a good question that would have deserved mention in the gemara itself, I think.
More than that, what is the etymology of karmelit? The Yerushalmi has it as:
כרמלית, תני רבי חייא כתיב (ויקרא כג, יד) ולחם קלי וכרמל, ומפרש כרמל, רך מלא נמלל ביד אינו לא לח ולא יבש אלא בינוני. והכא וגם לעניינינו הכרמלית אינה לא רה"ר ולא רה"י אלא כרמלית.It is an in between state. Rambam suggests likewise, giving the derivation as ke-armelit, "like a widow", who is neither married nor a never-married woman, but in an in between state. (The letters in lamnar, that is lamed mem nun resh switch off with each other, such that Hebrew Almana = Aramaic Armalta.) Both of these seem like folk etymologies, which are fanciful while speaking to the known implication or common usage of the term.
But I think there was an original real meaning of the term, which derives not from a Semitic language, but from some foreign tongue, perhaps Greek or Latin. And a karmelit was a type of place, just like a collonade or a valley. But, they seized upon karmelit as an exemplar for the whole group. At that point, rabbinic sorts of people forgot, on the whole, the original meaning of karmelit as specific domain X and instead treated it as class of domain Y.
So of course karmelit is part of the class of karmelit.
What is the specific (rather than class of) domain which is a karmelit? Rabbi Yochanan, in Yerushalmi, speaks of it as a known type of place. Thus:
איזו הא כרמלית? רבי יסא בשם רבי יוחנן כגון חנותיה דבר יוסטיני החנות של בר יוסטיני.None of the meforshim on the daf can really define the chanut of bar Yustini, because they don't have access to contemporary knowledge.
It is a logical guess to associate the two statements of Rabbi Yochanan, namely the one cited in Yerushalmi and the one cited in Bavli. Thus, when we see in Bavli:
When R. Dimi came,9 he said in the name of R. Johanan: This is necessary only in respect of a corner near a street.I would say that this is not coming to give an inclusion of a new item, which is how it is most simply understood and how it presents a difficulty to Tosafot. Rather, Rabbi Yochanan, as an early first generation Amora who had contact with Tannaim, is defining for us what was known to be the literal karmelit. Which would make this the definition of the chanut of bar Yustini.
The years of Yustini to Justinian do not work out, but there is a famous courtyard later associated with Justinian, so maybe we can put the precise reference to a later writer: Justinian's Augustaion. To cite Wikipedia:
Originating as a public market, in the 6th century it was transformed into a closed courtyard surrounded by porticoes, and provided the linking space between some of the most important edifices in the Byzantine capital. The square survived until the late Byzantine period, albeit in ruins, and traces were still visible in the early 16th century.
The square dates back to ancient Byzantium, before its conversion into an imperial capital by Constantine the Great. When Roman EmperorSeptimius Severus (r. 193–211) rebuilt the city, he erected a large square surrounded by porticoes, hence named the Tetrastoon ("four stoas"). In the center of the square stood a column with a statue of the god Helios.[1] In the 320s, Constantine adorned his chosen new capital with many new monumental buildings. His activities included new structures around the Tetrastoon, while the Augustaion was likely carved out of its eastern part at that time, and named after a Porphyry column supporting a statue of his mother, the Augusta Helena.[1][2] The Augustaion was rebuilt in 459 under Emperor Leo I (r. 457–474), and again in the 530s, after being destroyed in the Nika riot, by Emperor Justinian I (r. 527–565). In its original form, the square was open to the public and functioned as the city's food market (agora), but after Justinian's reconstruction, it became more of an enclosed courtyard where access was restricted. Byzantine writers from the 7th century on refer to it as explicitly as a court or forecourt (αὐλή, αὐλαία, προαύλιον) of the Hagia Sophia.[1][2]...
Enclosed on all sides, the Augustaion was entered in its western and southern side, respectively through the Melete and Pinsos Gates, from the Mesē, the city's main thoroughfare.[1] Directly outside the square stood the Milion, the mile marker from which all distances in the Empire were measured. To its north, the Augustaion was bounded by the Hagia Sophia cathedral and the Patriarchal palace (Patriarcheion), to its east by one of the two Senate houses of the city, built by Constantine or Julian (r. 360–363) and rebuilt by Justinian with a porch of six great columns adorning its front.Thus, if this is the same item the Yerushalmi refers to (!), then we are dealing with a square surrounded by porticos. Or a square, initially open to the public but later, an enclosed courtyard where access was restricted; where Justinian erected a column. We would need to work out the particulars, and scholars already have, for different time periods. But my guess is that this is somehow the karmelit to which Rabbi Yochanan refers.
Thus, this is a karmelis (3d reconstruction):


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How many buzz words can we cram in!? We don't like buzz words much. And besides, all the best ones are taken. Here are three reasons Thought Den make good things:
We get results. Eyes on the prize. Bums on seats. It's as important to us as it is to you that your project performs. A holistic, results-focused approach leads to products that know where they're going before they're out of the gate.
We work hard. As our name might suggest, we like to give things some thought. But in this world thinking is nothing without action and our close-knit team always go the extra mile. If it's worth doing...
We like magic. Call it a sense of adventure if you like; curiosity, enthusiasm or cunning. A way of working that looks beyond content & technology, searching for the spark and sense of character that defines a successful piece of work
©Thought Den Ltd. 2014
Ben Templeton


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Figures. Obama's Secret Service Bashes FOX News on Twitter
Figures. They just can't help it.
The leftists at Obama's Secret Service can't stand FOX News.
They even tweeted about it.
Hat Tip Ben
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As with anything in today's world, choice is something we are not short of. From clothes and shoes to supermarkets and insurance companies. And, when it comes to business and digital a full service digital agency like mmadigital is no different. There is a sea of choice out there when picking a full service digital agency. And knowing which one to choose is difficult.
Chances are, you are not even entirely sure of what it is that you are after? Do you need a new website? Do you need help with social media? How do you drive more traffic to your website? All of these questions can leave you frustrated. Especially when you still have your day-to-day job and the running of your business to contend with.
Well, that is where mmadigital comes in. We know exactly what to do and choosing the right agency is essential. So how do you know that we are the right digital agency for you? Here are some top tips on looking for the right digital agency like mmadigital:
Who have they worked with before? Does their website clearly and openly show the range of clients that they have? Are there testimonials and examples of work? If so then you know that this full service digital agency have experience and they are not afraid to show it. At mmadigital we ensure that you can get an understanding of the kind of work and clients that we have.
What is their own website like? If they are selling their full service digital agency tools to you then you need to know that they have used them on their own business. When you head to their website can you find it easily? Are you inspired? Does it show that they know what they are doing? Just take a look at the mmadigital website to see.
Social media
Are they active on social media? Does this full service digital agency have a lot of likes and followers? Are people talking about them? If so then this is a sign that they practice what they preach. When choosing a full service digital agency practicing what they tell you is of paramount importance.
Are they easy to contact? Have they called you back if you left a message? You want to feel confident that once you start working with them that they will be on the end of the phone or email whenever you have a query or need something done. Good client-agency relationships are essential to being a great full service digital agency and at mmadigital it is something that we take great pride in.
Nick Holmes is a writer for MMAdigital


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In this accurate replication of the Olympic diving event, show off your skills as you twirl and pose for the most points possible.
After jumping with SPACE, use the X, C, and V keys to cycle through positions, and the arrow keys to spin and rotate. Complete 3 dives to win.


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Well another 4 weeks and surf from waist high Cabarita to who knows how big at Snapper. It was reported to be 16m on some buoy off the coast, so there were 2 days I, along with the the other 99% of surfers decided it wouldn't be worth it. Of course Piper and Marlin Harrison were in the other 1%.
Melissa took a couple of shots of them playing in the foam of which there was lots, from Froggies to Kirra. At the height of the tide white water was rolling into the car park at Kirra.
There are 2 pictures of Froggies Beach and Snapper Point. The first has a guy taking pictures of the white water, the second is him gone, he got washed off his feet and ended up among the boulders, he was probably too close. Marlin and Piper dwarfed by a wall of white water.
During a massive swell in the 90's we left our car in the Kirra car park which was being continuously covered with spray coming off the rock retaining wall. On the news that night they had film of a car with ½m boulder resting on it's bonnet.
During the middle of the storm of this century I was safe and sound watching an AFL match when the phone rang, it was Harry, he said look out the front, I could just make them out, he and Mel had ridden down from Snapper and they wanted to know if I was going on my afternoon ride. Boardies and a rashie were the go as the normal dry 10km return ride to Snapper was under water sometimes up to 300ml deep, it was the best ride I've had. We had 353ml in the 24hr period on that Saturday.
Coolie Rocks was on again 1300 cars and as usual there's always a couple of different VW Kombi's to check out. The FJ four door ute was for sale, asking price $40,000.
See you in the surf


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Counseling Services
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But I digress. I should stick to talking about stitching. I need to buy a set or two of stretcher bars before I can start the ornaments. Which is just as well considering all the WIPs in the basket already. Even so, I have rediscovered a fondness for needlepoint and am anxious to start these little beauties in time for this Christmas. I am afraid I am like a kid in a candy store now that I am retired ... I want to do it all ... and all at once.
I have also been trying to gather all my stash in one place, a sort of pre-inventory browsing and organizing effort, if you will, In doing so, I have found four tubes of white linen I had forgotten I had, A godsend really since I thought I was all out of white and needed to restock. I also gathered up an appalling number of stitched but unfinished pieces that need to be transformed into useful or decorative items. I'll be taking care of the Fall pieces first, and then the Christmas and then the miscellaneous.


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"The average American farmer is 58 years old. The average cattleman is 61 years old.
According to Beef USA, 90% of all U.S. cow herds have less than 100 cows. So there is a declining population of people, with small herds, with growing challenges – and despite the current bubble — a disincentive to carry the ranch forward another generation, in the face of hunger and a growing demand for food.
The good news is there is a new generation coming on that wants to farm and ranch and they are exploring new paradigms – problem is they often can't afford the land, and there are programs with land trusts, USDA and others to assist — and they desperately want training — not only in production but management to run a smaller, efficient, profitable healthy enterprise. And interestingly many are doing it. Many of them are women – 30% of the 3 million farms are operated by women – today, women are twice as likely to take over an existing enterprise or starting a new one than men."
"The Women and Food Agriculture Network has information indicating that – since 2002 – the agriculture industry has seen a 30 percent increase nationally in the number of women running farms and ranches. If you look at demographic, social, and economic factors, they indicate that the number will continue to rise in the coming years."
I have a banner on my Facebook page that says "No farms=no food".
It is true now more than ever with shrinking availability of land, fewer and fewer programs to help new farmers and a retiring group of farmers. The U.S is ahead of Canada in their efforts to try and help the next generation of farmers, and this needs to be rectified. Every country needs to help their farmers, and in the end, help stem the food crisis we all experience.


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Taylor Polka Dot Wrap Dress: Direct Link / Coat: Springfield / Boots: ZaraI have to say I am so happy to be finally back on the blog, it has been way too long! Over the last couple of months, I have had to put all things Fashion Aid to the side which I have to admit hasn't been easy. I am in the final couple of weeks of my bachelor honours degree in Business Studies specialising in Marketing and to be honest every second I get during the week is either spent on college work or winding down after a hectic day.
To kick off my Easter holidays I flew to my Mum here in Le Mans, France on Friday morning and I couldn't have been more excited! As you will see from the pictures Le Mans is so beautiful and the old town is like something from a movie.
I have only had this polka dot wrap dress a couple of weeks but I absolutely love it. It was a particularly hot day on Sunday here in France so I actually got to wear it without tights but in Ireland that has not been an option! It is one of those pieces you can easily dress up and down which I always find a life saver especially when I am in a hurry which let's face it is the majority of the time at the moment.
Over the last couple of weeks, I have popped up some new content over on the Fashion Aid Instagram featuring new pieces from www.iclothing.com. Instead of shooting them all individually on here also I just said I would pop the pictures along with their direct links for anyone interested in purchasing any of the items.
Polka dot bodysuit: Direct Link / Leather Skirt: Direct Link / Boots: Zara
Coco Jumper: Direct Link
Casha Pearl Detail Cardigan: Direct Link
Taylor Polka Dot Wrap Dress: Direct Link
Lucy Classic Trench Coat: Direct Link
I am so excited to get back into the swing of blogging once all of these final exams are out of the way and my degree is finally in the bag. If any of you guys are preparing for finals or any exams, in general, hang on in there....the hard work always pays off in the end!
I have another two trips to look forward to on my Easter break, so keep an eye on the Fashion Aid Instagram for lots of travel content which I absolutely love sharing (in case you haven't noticed I have the travel bug big time)
Thank you so much for always supporting me and the blog by the way it means so much!
Thank you so much for always supporting me and the blog by the way it means so much!
Have a fab Easter and hopefully it won't be as long until the next post,
Éadaoin xoxo