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Attention: Winchester Home Owners! Serious About Getting Windows & Siding, You Must Read This...
…..so there I was ten years ago in Springfield driving down a residential street headed to the home of Mr. and Mrs. Clemmons. It was three o'clock in the afternoon and I'm late. You see, I wanted to be here earlier around nine but because of a doctors appointment i'm running late.
Six days earlier Mr. and Mrs. Clemmons decided to purchase new siding for their home and trusted me to perform the job.. (after all ,I'm a professional…right?)….so I put one of my best crews on the project led by Josh. (He's done hundreds of beautiful installations for me over the last couple years and he was starting this one this morning.)
I always make it a habit to show up the morning of the first day of construction. But heck,it's Josh…..no worries….i'm running late!
I pull up to the Clemmons home. Where's Josh? It's three o'clock and the job has not been started. I'm pulling out my phone getting ready to call him when i happen to notice some activity across the street….well….there he is.
He was sitting in his truck at the time and three of his guys were on the side of the house installing siding. They have been there since eight o'clock ….and since they do move pretty fast they have already installed the entire rear and one side of the house. Wow! It sure looked pretty….but…as you've ..probably already guessed..we have a minor problem today.
Wrong house!!!
The next few hours, were to say the least….well lets just say amazing….(i'll tell you later what happened. I'm out of typing room) Call Jeff (816) 738-4889
(816) 738-4889
I'm Here To Help!
Siding Installation Companies Winchester
Siding Installation Companies Winchester - If you live in Winchester and are in the market for windows or siding, let window and siding professional Jeff Smith help you. Being in business for over 20 years running, we have the most competitive pricing around and offer financing.
If your house is starting to show its age, we want to restore it to its old glory. Install energy-efficient windows and doors that provide security and save you money. All installers are factory-trained and certified to ensure that your windows function properly and save energy for a life time.
Replacing windows and doors can be tricky. Getting the best advice that you can is in your best interest in any home remodeling scenario, but that is particularly true in windows and doors. They not only protect your home from the elements, but they also protect you from other things as well. The first line of defense against storms and even intruders are the doors and windows that you install.
For over 20 years, we have provided what it takes to protect homes and make them look beautiful. Depend on us for top-quality products at competitive pricing—we make sure to fit any budget. We enjoy transforming customers' houses and seeing our customers' faces when they see the final results.
Are you ready to add a little curb appeal as well as to boost your energy efficiency? Would you like to add some easy and reasonably priced adjustments to your home and increase the value dramatically? The top way to accomplish that is to add new exterior doors and windows. Hiring a residential window installer in Winchester is the surest way to provide for your home security and to ensure that your window installation in Winchester goes off without a hitch.
Learn More About Siding Installation Companies Winchester
When you're seeking new windows, make sure that you also seek out the best window replacement company that you can find. Making sure that you get the best may be a bit more costly but the overall effect will be that your home gets the best that you can give it. What is the Upside of Getting New Doors and Windows? Some of the most popular types of doors and windows that homeowners select today are wood entry doors, French doors, steel core doors, or fiberglass doors. Each one is beneficial in its own way and each one provides for a more energy efficient way to live. Green living is all the rage but green living is also a great way to keep more money in your pocket. Windows are an essential element in your home's livability. They are its eyes, ears and even nose, letting in light, sound and scent. At the same time, windows can draw in and hold warmth, welcome a natural breeze or banish a frigid wind. If you live in Winchester, Good-quality, energy-efficient windows are a must.
If you live in a storm-prone or hurricane prone area, you're sure to want to have windows that are shatter proof at the very least. The installation of these windows requires an expert in installation as well as an expert and experienced company who can offer you valuable insights into the best windows to get for your area and your situation. The best doors and windows that you'll find and the ones that will be well suited for insulating your home will be double glazed windows. These windows shut out the heat and cold, allowing for greater comfort and greater energy efficiency in the house. Again, recommendations of an experienced company as to which windows are best for your home or office will be priceless and help you to avoid making costly mistakes when it comes to installation of your windows.
Why Hire an Expert Window Installation Company?
Just as you wouldn't hire a plumber to put your braces on, so too you don't want to hire a general contractor or one that doesn't know windows and doors to install yours. Doing it yourself may seem like a viable solution to you but the reality is that when you're living in an area such as Winchester where weather or other things can factor in, you'll want the advice of an experienced window installation company to help you to choose the right windows and doors.
When it comes time to install new doors and windows, hire the best window installation company for the job. Jeff Smith as the experience that you need to help you to get the most for your remodeling dollar. If you're looking for top quality workmanship, expert advice and the very best in customer service, you need to call Jeff Smith today!!
Siding Installation Companies Winchester - (816) 738-4889


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Every Saturday at 3 p.m. at MJM, certified yoga instructor Chelsea Best conducts Awesome Asana Yoga, an open-level Vinyasa class designed to accommodate beginners and experts alike. All are welcome, and mats, if you haven't one, are provided. The class is $5. No registration is required. Check out Chelsea's website for more information.
Back to All Events
Earlier Event: February 27Tour - Docent Guided
Later Event: February 28Yoga - Awesome Asana


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Usain Bolt runs season's fastest 200 in Paris
PARIS -- Forget for a moment the laid-back, fun-loving Usain Bolt. Even when he's winning the six-time Olympic champion is finding fault with his running these days.
The Jamaican sprinter gave himself a grade of 7 out of 10 after running the fastest 200 meters of the season Saturday with a time of 19.73 seconds at the Areva Diamond League meet in Paris.
Bolt shaved 0.01 second off the previous best time this year, set by American sprinter Tyson Gay at the U.S. trials last month.
"I think I could have run the last 50 after the turn much better," Bolt said. "I didn't come in the straight as powerful as I used to. The last 30 meters, I was kind of, I won't say struggling, but my technique wasn't perfect."
Fellow Jamaican Warren Weir was second in 19.92, ahead of former European champion Christophe Lemaitre in 20.07.
"The time, I think I could have done better," Bolt said. "I wanted to do better, but it's just one of those things you never get but you wish for sometimes."
Bolt broke the meet record of 20.01 seconds set by Michael Johnson in 1990. But he said he still has plenty to work ahead of the world championships in August.
"First, I think I should have run faster on the curve," he said. "My first 50 was great. But then, for some strange reason, my last 50 wasn't so great. So I just need to figure what went wrong and then work on it."
However, Bolt laughed off suggestions that he was past his prime after losing to American sprinter Justin Gatlin in the 100 of the Golden Gala meet last month in Rome.
"I lost one 100 meters, a lot of people are making a big deal of it," Bolt said. "It doesn't really bother me. All I have to do is just train. The same people in that lane beside me, if he's one of them, then I'll get it right that I'm a championship person. I'm not worried."
Bolt will next compete in the 100 and 4x100 relay in London on July 26-27 in a one-year anniversary event for the 2012 Olympics. That will be his final major meeting before the worlds, which start Aug. 10.
In other events at the Areva meet, the ninth leg in the Diamond League circuit, Olympic champion Kirani James of Grenada clocked a world-leading 43.96 in the men's 400, beating Americans LaShawn Merritt (44.09) and Tony McQuay (44.84).
"Today in comparison with previous races, I had a little bit better first 200," James said. "You need to always pay attention to runners like LaShawn. If he would be too far ahead, it would be tough to beat him."
James caught Merritt in the backstretch before running away on the final straight.
"I could have done better," Merritt said. "Some parts of my race were slower than they should be. But I will correct it. To win in Moscow, I need to use my speed. That is the key."
Merritt won gold at the 2008 Olympics and the world title in 2009 before completing a 21-month suspension for failing doping test.
Three-time Olympic champion Tirunesh Dibaba of Ethiopia ran 14:23.68 in the women's 5,000, also a world-leading time this season.
Reigning world champion Ezekiel Kemboi of Kenya ran the fastest 3,000 steeplechase this year in 7:59.03. In that same race, Frenchman Mahiedine Mekhissi Benabbad set a new European record with a time of 8:00.09.
In the women's 100, Olympic champion Shelly-Ann Fraser-Pryce held off a late charge from Blessing Okagbare of Nigeria to win by one hundredth of a second in 10.92. U.S. champion English Gardner finished a distant fifth in 11.13.
World record-holder Aries Merritt of the United States led from start to finish to win the men's 110 hurdles in 13.09. Frenchman Pascal Martinot-Lagarde came second in 13.12, edging third-place American David Oliver (13.13).
Olympic champion Anna Chicherova of Russia leaped 2.01 at her first attempt to take the women's high jump, three centimeters higher than U.S. champion Brigetta Barrett in second and former world champion Blanka Vlasic of Croatia in third.
The next Diamond League meet is in Monaco on July 19.
Copyright 2013 by The Associated Press
This story is from ESPN.com's automated news wire. Wire index
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Aside from prominent figures , political activists and reporters from local and foreign media , thousands of Abu El Fotoh supporters from young people attended the big event cheering the man and saying "The people want Abu El Fotoh as a president" and "Down with the military rule"
|The audience at the conference
|Abu El Fotoh's supporters "Abu El Fotoh campaign"
|Abu El Fotoh supporters from prominent figures
"Abu El Fotoh"
|Abu El Fotoh, Hamdy Kandeel, Athar El Hakim
"Abu El Fotoh campaign"
|The supporters of Abu El Fotoh
"Abu El Fotoh campaign"
It is worth to mention that the event was translated to the deaf in a very rare incident in the Egyptian political history.
|Abu El Fotoh advising team "Abu El Fotoh campaign"
Then there was the big speech. The big speech was Abu El Fotoh's presidential promises in nutshell , some of them I have already heard at the Jesuit lecture last week already. Still there was something interesting new promises like :
|Abu El Fotoh addressing the public
"Abu El Fotoh campaign"
- His talk about agriculture
- His promise to make Egypt one of the top 20 strongest countries.
- He will cancel military trials and will order the retrial of those who had military trials in the past in front of civilian courts.
- He will return security to the Egyptian street in 100 days !!
- Having the strongest army in the region and increasing the number of personnel because in the end real renaissance needs protection.
- He will diversify in the sources of our army's weaponry and will revive the Arab organization for industrialization.
- He will focus on the stability of Sudan and Palestine as well the unity of Libya and Syria as they are part of our national security.
- Egypt will be from the richest countries in the world in 10 years
The liberal vibe was more obvious than the Islamist vibe. I think Abu El Fotouh spoke about Islamic Sharia and in Islamic term for few minutes in his speech.
The Islamist presidential candidate who admitted in his memories that he did not like Gamal Abdel Nasser for years addressed the audience using the same techniques of Nasser. The speech of Abu El Fotouh had the same component of Nasser's speech with his talk about social justice , dignity , national security , agriculture and promises of better future.
Abu El Fotoh's campaign inaugurated the merchandise kiosk in the event where you can buy Abu El Fotoh T-shirts "which are very stylish" , bags, mugs and pens in order to help the campaign.
|Abu El Fotoh's merchandise by Mohamed Habib
|Misr Qawya T-shirt by
Of course that event is not enough to secure the way to the presidential palace , it is just the start.


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FOXBOROUGH, Mass. – Clint Dempsey's return to Major League Soccer last August was billed as the U.S. National Team captain's "homecoming" after seven years in Europe, but for fans of the New England Revolution, Dempsey won't truly be home until Sunday night.
That's when the former Revs star will make his long-awaited return to Gillette Stadium with top-of-the-table Seattle Sounders FC, which carries a five-game winning streak into Foxborough thanks in large part to Dempsey's league-leading eight goals.
"He's in a great bit of form at the moment, which is great for the U.S. going into the World Cup," said Andy Dorman, one of only two players on the Revolution's current roster – along with Shalrie Joseph – to have played with Dempsey in New England. "Obviously on Sunday we've got to try and stop him."
Dempsey, who was drafted by the Revolution in the first round of the 2004 MLS SuperDraft, earned legendary status with the club despite only spending three years in Foxborough. He followed up a Rookie of the Year campaign in 2004 with MLS Best XI selections in 2005 and 2006, helping guide the Revs to MLS Cup appearances in his final two years.
After notching 25 goals and 14 assists in 71 regular-season appearances with the Revs – and establishing himself as a U.S. National Team regular – Dempsey made the leap to Europe in 2007, becoming the top-scoring American in the history of the English Premier League (57 goals) during stints with Fulham and Tottenham Hotspur.
Now Dempsey is back stateside and leading the line for Seattle, which will present a stern test for the Revs on Sunday as they aim to continue their own fine run of form (3-0-1 in the last four). Dorman noted those circumstances in highlighting the importance of the game, but also admitted that he's excited about the opportunity to match up against his former teammate.
"We're looking forward to the game," said Dorman. "It's definitely the sort of game you want to be playing in. I'm excited to see [Clint] and play against him, because I haven't since the last time he was here in training. It'll be good."


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With a howl and a grunt, Saturday's monster presidential debate was off.
Decked out in suits and ties, Wolf Man and Frankenstein roared toward each other, past a row of American flags on stage at the Alex Theater in Glendale.
After a brief wrestle, Wolf Man extended his hairy claw and long black nails to shake his opponent's green hand.
When the Alex Film Society planned to screen "Frankenstein Meets the Wolf Man," actors Daniel Roebuck and Perry Shields — who Saturday played Wolf Man and Frankenstein, respectively — thought it would be fun to put on a monster debate, just in time for Halloween and Election Day.
The monsters would be taking on the hot-button issues, like voter fraud, said producer Randy Carter. "People seem to be voting twice," Carter said, with a laugh. "They're confused about being dead and undead."
Energy was a contentious issue for the two monsters. While Electrical Party candidate Frankenstein called for "a lightening rod on every laboratory," Wolf Man touted the "power of the moon."
But Frankenstein assured voters he was a man of the people. "In fact, I am a man of 10 people!" he screeched.
Wolf Man wasn't convinced. "I hope you can prove with a birth certificate that every one of those 10 people was born in the U.S.," he snarled.
The pair were scheduled for a second face-off at 8 p.m. Saturday. To hear more about the monsters' platforms, watch their campaign ads online at www.docshocker.com.
Follow Alene Tchekmedyian on Google+ and on Twitter @atchek.


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-Please subscribe to the blog. No cost. That way you'll be notified of new posts.
– I received an email this week from a faithful reader requesting features. A great idea, and starting next week you'll see something along those lines.
-This week I posted two commentaries. And, you'll be seeing more of those, also.
-At the upper left corner there's a sidebar "Popular Post." It lists the threads with the most comments. Feel free to go back in time. If something jumps out at you, comment under the latest "Loose Threads."
-I am not a tech genius by any stretch. I've started adding some links and you'll see that segment gradually growing. If there are any links, either Mets or baseball, let me know.
As always, thanks.-JD


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It begins to be clearer to me, Joan. But I'm still working out how to realize that on the 4th floor...
Oh my! That means a lot of work! Do you have that much energy? At this stage of my life, I do not have that kind of energy, in fact, I am just enjoying my garden now, after 38 years of planning, planting and pulling. Are there others in your building who would like to share i the project? Preferably, strong and young. This age thing has some benefits, but energy isn't one of them. At least for me. I will be interested to learn what you come up with.
Maybe a subscription to a garden magazine. Oh dear, my age is showing.
I think I'm on my own, at least until the cars have rusted away in the parking places, then I expect my neighbours to help me break up the parking lot ;-). I haven't got much energy, and I've got a bad back, but I can handle a lot in a slow way. One by one I attack my garden crates: fertilize and weed out things I won't need, and make a planning for sowing. I can move the crates with a handtruck if necessary. I often do ´ten minute jobs´ or I work until my back hurts - not long - but I always get more work done than expected.
The permaculture idea is to disturb the earth as little as possible: it really sounds promising to me!
Permaculture is a laudible intent. It's hard for me to live by it but the thought is always there. I like the idea of multi-function plants and think about that a lot.
As time passes I'm hoping for my garden to mature into a more self-sustainable form. I have to plan now for the future when I can't do as much - raised beds are easier to maintain than regular garden plots, for example. Once mature, fruit trees should be easily maintainable for a long time. I keep them pruned compact, so no ladder is needed. So far. The prunings immediately become mulch, to hold in water and keep down weeds.
I think when I get enough raised beds in place, I can grow "green manure" in them in a rotation, so I don't need to bring in as much compost. Green manure is a cover crop that adds nitrogen, complex carbohydrate, and improves fertility. Examples are buckwheat, fava beans, and clover.
I've been reading about soil structure and the effects of tilling. It seems to me that sometimes tilling is needed. For example, to work in compost and aerate a compacted, mistreated soil that is not fertile and does not drain. But overdoing it damages the architecture and microbial flora, and results in loss of soil carbon compounds and nitrogen, to the atmosphere. Therefore excessive tilling should be avoided. That's a balance I have not achieved. I do use a shovel, not a tiller. I'm a bit addicted to digging.
This was one article I've been reading - about large scale farm, not gardening. But some lessons can be learned. It shows the negative effect of tilling, as far as soil structure is concerned. There is a lot of debate out there as to whether fungal (mycorrhizal) and bacterial (rhizobium) inoculants are needed. Maintaining those populations would have a role in permaculture. What seems to be clear is that as the fungal population increases in the root zone, trees shrubs and smaller plants all benefit,. Severe tilling (rototilling) can cause long term damage to the fungal structures - so not a permaculture method.
Still a lot to learn, and interesting topic! Here is the permaculture forum on gardenweb.
I like your response, and indeed, permaculture has its place in gardening. I agree to prepare for those days when energy is gone ... I am at that place now and love it. I just sit in my garden and let it grow over me. I doubt if anyone will be able to find my body because I have so many lovely beneficial things growing, they will just decompose me in place, leaving behind my shoes and teeth. I like that image. I didn't like tilling because I didn't like to work that hard, and hand turning was not my favorite thing either. But growing soil isn't about humans turning the soil, that is the responsibility of the worms and all their friends.
Thanks for the permaculture forum link and The Biology of Soil Compaction. My neighbor kids know there is one rule they cannot violate: DON'T STEP ON THE SOIL! When the younger ones come over and stepping stones are too far apart, we all work to put in the necessary extra places to step. The kids seem to love the rule and help make it work.
Thanks for the link to the article Joan.
I like this topic. It's becoming more common, I think. Or I'm becoming more aware. My gardening is not "permaculture" yet, but I try to guide my thoughts and actions in that direction.
-More mulching, which retains moisture, builds the soil, reduces weeds, reduces labor. It would be nice if I could produce my own mulching materials, but so far I get a lot from other places. Still, I do collect leaves, pine needles, and grass clippings on my property.
-Recycle everything I can via compost, when I use the woodstove, the ashes go back into the soil around trees, using cardboard packaging and newspaper as a bottom layer for mulch in areas where weeds or grass become a problem.
-If something looks like it needs pesticides to survive, I don't grow it. Example is peach leaf curl. That disease devastates most peach varieties here, is treatable with sprays, but Im planting leaf-curl-resistant varieties instead. Similar, growing disease resistant apples and pears, to avoid sprays.
Random thoughts. This is a great topic for people who want to live in harmony with nature.
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Economic Development
Because one size doesn't fit all, please use the zoom feature of your browser to increase or decrease the text size.
The City of Des Moines is a great place to locate or expand your businesses. The Des Moines Office of Economic Development office is dedicated to helping you meet your existing and future development needs.
More Info
The Engineering Department's efforts include the design, construction and project management of the City's Capital Improvements Program (CIP) and other major construction projects.
The Office of Economic development is committed to helping businesses grow and prosper. A variety of business incentive programs, financial assistance, tax assistance and training programs are available to businesses that are located in Des Moines or that are interested in locating in Des Moines. Many small, medium and large companies in Des Moines have worked with City to make their start-up or expansion plans a reality.
Urban renewal provides reasonably-priced sites for new development and business expansion in specific areas throughout Des Moines. The City makes significant investment in the infrastructure in these areas.
Staff for urban renewal assists developers by assembling parcels in designated urban renewal areas. These areas have consistent development requirements that enhance your investment. Staff works with developers in determining development requirements that enhance your investment. Staff works with developers in determining development requirements for assembled sites. Sites are offered at a price that is usually less than the cost of private assemblage. In addition, the City coordinates infrastructure needs for the area and the specific site to assure that current and future needs are met.
Although the City does not maintain an inventory of developable parcels in Downtown Des Moines, staff works with the development community on an ongoing basis to identify parcels suitable for a variety of business needs.
For location options to suit your particular business need, please contact the Office of Economic Development at 515-283-4004 or at firstname.lastname@example.com.
Incentive Information
Business and Industrial
Economic Development Plans
The Office of Economic Development was established to stimulate industrial and commercial growth, to retain and create new jobs for residents and increase the City's tax base.
Staff is available to assist businesses, developers and contractors in a number of areas, such as site identification, the development review process, financial assistance programs and urban renewal.
Project Managers can provide site-specific information and resolve complex issues which allow projects to proceed.
Project Managers provide a central point of contact for businesses or developers seeking help with development questions. They take a pro-active stance, anticipating what will be encountered in the development process. Often the Project Manager can identify financial programs to assist the project.
Financing Coordinators can fit the different financing programs together for your project.
Financing assistance is intended to leverage additional private investment. Financing Coordinators administer financial programs and incentives available for development within the City. Financing sources include urban renewal, federal CDBG funds, and Small Business Administration funds (SBA 504). They identify and package the appropriate financing assist with the preparation of the application.
Financial assistance information
The Office of Economic Development does not maintain a listing of development sites in the corporate limits of Des Moines. We work very closely with the development community, however, and are available to assist you in identifying the best location for your business.
To explore the opportunities available in the City of Des Moines, please contact the Office of Economic Development at 515-283-4004 or firstname.lastname@example.com.
Business / Financial assistance information
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Tax Abatement information


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The Internet, a global system of interconnected computer networks that has transformed the lives of billions of people across the world, turned 30 on Tuesday.
Although the origins of the Internet reach back to research of the 1960s – commissioned by the United States government to build robust, fault-tolerant, and distributed computer networks – 1 January 1983 was the day that the Internet as we know it replaced previous networking systems.
It was the day the US Department of Defence's ARPANET network fully switched from the older Network Control Program (NCP) protocol to the Transmission Control Protocol and Internet Protocol (TCP/IP) communications system, which now underpins the entire Internet.
The reason for the switch was that ARPANET had roughly 1,000 computers connected on the network at the time, and it was growing fast, so to handle the larger and increasingly complicated network ARPANET needed a new protocol.
Vint Cerf, VP and Chief Internet Evangelist at Google, was part of the team that developed a new computer communication protocol designed specifically to support connection among different packet-switched networks.
In a blog post to mark Internet's thirtieth year, Cerf, who is widely regarded as the "godfather of the Internet" said that the main emotion he remembers looking back on that day was relief.
"There were no grand celebrations – I can't even find a photograph. The only visible mementos were the 'I survived the TCP/IP switchover' pins proudly worn by those who went through the ordeal," he said.
"Yet, with hindsight, it's obvious it was a momentous occasion. On that day, the operational Internet was born."
English computer scientist Tim Berners-Lee later used the new Internet protocol to host the system of interlinked hypertext documents he invented in 1989, known as the World Wide Web.


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This is the first of my regular emails to you all. I will try to keep them infrequent, and brief, but this is the best way to communicate with all of you at the same time, so please DO read the emails I send out.
Firstly, I have attached an up-to-date schedule for Co-op appointment availability. If you have hours in the Co-op, check the schedule, and make sure it's accurate. If there are issues, you need to let me know as soon as possible.
Next, tutoring starts on Monday. Some of you may have already gotten emails, or appointments made for your Co-op hours. Remember, each session needs to be recorded in TutorTrac. You can't be paid for time unless there is a session in TutorTrac; if you have any questions, let me know. Here are some things to keep in mind:
-Know your resources. The professor is the best resource for a student. You should always encourage a student to visit office hours. Also, keep in mind Learning Skills tutors, writing tutors, TAs, departmental help sessions, SI sessions, and the like, whenever applicable.
-Professional tutoring does NOT include: complaining about professors, other tutors, or Learning Co-op staff; texting or talking on your phone; arriving late to or leaving early from a session, unless previously negotiated; working on graded assignments (unless arranged with an instructor).
-One individual appointment per week, per subject. No exceptions to this policy, but group sessions are unlimited.
If the expectations for you as a tutor are at all unclear to you, please come in and talk to me.
The next payroll submission deadline (all PeopleSoft and TutorTrac records) is Sunday, September 15 at midnight. Any time that doesn't match between systems, or not submitted by then, will not be approved. Your pay will be delayed until the next pay period. Be sure to clear up any confusion by then (or earlier, of course).
Finally, here are some course requests which we currently cannot accommodate. If you, or perhaps someone you know, can work with one or more of these courses, let me know. As of right now, these are the courses we are trying to cover:
Many thanks,


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Inside Sons & Daughters' "Goodbye" Party
Apr 4, 2006 4:00 AM EDT
Tonight's episodes of Sons & Daughters [starting at 9 pm/ET on ABC] will tease, titillate, and traumatize you. First up is "House Party," written by Jordana Arkin and directed by Bob Berlinger. Prepare yourself for some outrageous behavior when… Read more


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Aug 10, 2007 (CIDRAP News) – Global health officials have long feared genetic changes that would make the H5N1 avian influenza virus more easily transmissible among humans, but a new report from researchers at the National Institute of Allergy and Infectious Diseases (NIAID) predicts some of the crucial mutations, which could open the door to preemptive vaccines and treatments.
The report, published in today's issue of Science, details the work of a research group led by Gary Nabel, MD, PhD, director of NIAID's Dale and Betty Bumpers Vaccine Research Center. The group created mutations in the region of the H5N1 hemagglutinin protein that directs the virus to bird or human receptor cells and elicits antibodies to it, according to a NIAID press release yesterday.
"What Dr Nabel and his colleagues have discovered will help prepare for a future threat," said National Institutes of Health director Elias A. Zerhouni, MD, in the press release. "While nobody knows if and when H5N1 will jump from birds to humans, they have come up with a way to anticipate how that jump might occur and ways to respond to it."
Typically, producing a vaccine to protect against H5N1 or another influenza virus strain is a laborious process that can take up to 6 months after a pandemic strain emerges. Scientists must isolate the strain, grow it in eggs or cell culture, and combine the purified virus with other vaccine components.
However, Anthony Fauci, MD, director if NIAID, said in the press release that researchers' findings on the artificially mutated viruses enable scientists to start considering the design of new vaccines and therapies to treat people who may someday be infected with an avian influenza virus that naturally mutates into a pandemic strain.
"This research could possibly help to contain a pandemic early on," he said.
Nabel's group focused on mutations that allow the H5N1 virus to better recognize and enter human cells, the press release said. To determine what mutations allow the virus to shift its adaptability, they compared proteins on the surface of the H5N1 virus, which are bird-adapted, with surface proteins on the human-adapted virus that caused the 1918 pandemic.
Focusing on genetic changes to one portion of the H5 protein, called the receptor binding domain, they found that as few as two mutations could enhance the ability of H5N1 to recognize human cells, according to the press release.
Nabel cautioned in the press release, however, that more mutations would likely be needed for the H5N1 virus to more easily spread between humans. He emphasized that the mutations he and his colleagues identified are probably just a subset of that dangerous group.
To assess how the immune system responds to the mutated H5N1 viruses the authors ran mouse studies, which revealed that mouse antibodies were 10 times less potent against the mutants. Then they created vaccines and isolated new antibodies that might be used to fight the mutated virus, the press release stated. When they vaccinated the mice, they identified one broadly reactive antibody that could neutralize both the bird- and human-adapted H5N1 virus forms.
The findings should improve H5N1 surveillance, Nabel said, because they make it easier for scientists to recognize dangerous mutations and identify structure-based vaccine candidates that might be more effective against the virus before it emerges.
"Insight into the structure of the avian flu virus has enabled us to target a critical region of HA [hemagglutinin] that directs its specificity," he said in the press release. "Such a structure-based vaccine design may allow us to respond to this future threat in advance of an actual outbreak."
Yang ZY, Wei CJ, Kong WP, et al. Immunization by avian H5 influenza hemagglutinin mutant with altered receptor binding specificity. Science 2007 Aug 10;317(5839):825-8 [Abstract]
See also:
Aug 9 NIAID press release


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That was the case last Thursday when students from Lafayette High School left their books behind and made their way onto a football field lined with obstacles as part of a Spartan Race.
In recent years, the sport of obstacle racing has grown in popularity and the students were able to challenge themselves at a "high school" version of the real thing.
The obstacles included flipping a 650-pound tire, getting over a five-foot wall, crawling through a rubber tube and ending with a minute of "burpies."
The larger version of the Spartan Race takes place on a three-mile course that feature obstacles with fire, electricity and even barbed wire. However, none of those were on hand for the high schoolers.
Instead, the idea was to teach the students camaraderie and that you can't expect to be ready for every obstacle that life will throw your way.
Five schools operate on the grounds of the Lafayette Education Complex at 2630 Benson Avenue in Gravesend, but the High School of Sports Management was the one behind the obstacle course on school grounds.
"I think through sports you can accomplish many things," said Principal Robin Pitts. "So with a campus that's divided up into five schools sometimes children don't get to see each other, so the best way to bring unity on a school campus is though sports."
Pitts went on to thank the Reebok Spartan Race for approaching the high school and asking them if they would be willing to allow the students to attempt to conquer the course.
"The skills that kids really learn don't really come out of the textbook," said Pitts. "They come through relationships with people. Whether the relationship are with their classmates or with adults in a building, it's really about the nurturing and how we make better citizens."
One student from the Exceptional Learning School for Community Leaders, Eddie Luca, 17, ran the course twice. During his second trip, one of his friends was struggling to complete the last challenge of burpies. Luca, along with other members of the five schools did the challenge along side the student and cheered him on as he completed the last leg of the Spartan Challenge.
"I saw my friends, and they were struggling," he said. "I have to push them and make sure that they go harder. You know you don't want anybody to quit."
When asked what he learned from the obstacle course, Luca said to push to one's best and never give up.
Don Devaney a representative from Spartan Race, gave a speech telling the students that the course was a metaphor for life. And that life gives individuals obstacles they might not be prepared for, but that still need to be conquered.
"We create challenges that bring obstacle immunity to people," said Devaney.


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Ed Schroeder is a natural leader with energy and enthusiasm to spare. He has an easy going nature and good humor, which only add to his dynamic personality. What he loves best about his job in real estate is meeting and working with people. He works hard to offer his experience, great service, strong negotiating skills and the growing of long-term relationships with his clientele. He assists in delivering the dreams and goals of his clients. He develops true lasting friendships with his clients. He listens to their needs and chooses properties that hold their value and match his clients' wants and needs. Whether a buyer or seller, clients benefit from his service.
Ed has many things that he enjoys: a long cruise with someone special, taking a long hike on a sunny day in the mountains of New Mexico, a foot of new powder snow on an untracked ski run, and sharing the excitement of his clients when they buy or sell a home. Having been a U.S. Marine Corps Officer for 30 years of service, he and his wife, Mary, raised their adopted sons, Peter and Andrew, with respect for honor and service to the community. They both deemed these as valuable assets in life. As a real estate professional, Ed provides a unique advantage to his clients with these powerful traits. He understands that when one is being relocated in or out of the Santa Fe area, there are very specific and unique needs that must be met. He brings a wealth of experience in delivering a professional quality of service to his customers with the highest integrity. He understands that being a real estate professional is neither a career nor a profession; it is a way of life. Ed works to honor his clients' dreams and goals.
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