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When you need a new or upgraded cooling system in Germansville, trust Jack Lehr for expert air conditioning installation at a great value.
Your comfort is guaranteed when you choose Jack Lehr to install your new home cooling system. HVAC technology has come a long way in the past few years, which means investing in a new, energy-efficient central air conditioner or heat pump is a great way to lower your energy bills and increase your home's comfort levels.
And with professional cooling installations by Jack Lehr, you can be sure your system is installed properly. We use NATE-certified technicians—never subcontractors—who are familiar with all Pennsylvania building and safety codes and aim to meet or exceed industry standards.
Contact us today for a free estimate on your new central air conditioner or other cooling system in the Germansville area.
Central Air Conditioning Services in Germansville
Keep Cool with Jack Lehr
Shopping for a new central air conditioner for your home? Jack Lehr can help! Our technicians can help you determine the best size and system for your home's unique cooling needs.
Upgrading your aging system to a newer, more efficient model will not only improve your home's comfort—no matter how hot it gets outside—but will also save you money on your energy bills. And if you're interested in installing a dehumidifier, WiFi-enabled programmable thermostat, or other HVAC part or accessory, we can help there, too.
Give us a call for a free estimate on a central air conditioner in the Germansville area.
Ductless Air Conditioning
If you're looking to only cool certain areas of your home, consider installing a ductless system. At Jack Lehr, we're proud to be a Mitsubishi Diamond Dealer and sell and install Mitsubishi Ductless Mini Split Systems all over the Germansville area.
These systems offer easy installation as well as superb energy efficiency and savings. Contact us today to see if ductless air conditioning is the right cooling option for your home.
Heat Pump Installation & Replacement in Germansville
Experience Year-Round Comfort
Don't let the name fool you—heat pumps work year round to heat and cool your home. Switching to an electric heat pump is a great way to realize long-term energy savings and increased comfort.
So if you're looking to upgrade your current cooling system, look no further than a heat pump installed by the experts at Jack Lehr. We sell and install only top-of-the-line products, including variable speed heat pumps designed to heat or cool your home as efficiently as possible.
Get a free estimate on a heat pump from Jack Lehr today, and get ready to experience perfect home comfort throughout the year—no matter the season!
Go Geothermal
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When you're investing in a new cooling system in Germansville, we invite you to explore our geothermal options. At Jack Lehr, we sell and install geothermal systems designed to provide your home with perfect comfort year-round powered by clean, renewable energy.
If you choose to invest in a geothermal unit, you'll get more than just central air conditioning. Geothermal units are the ultimate multi-taskers—providing your home with heating, central air conditioning, and hot water. You won't have to worry about maintenance or repair for multiple systems each year—it's all the same unit!
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When you're looking for a central air conditioner, ductless system, heat pump, or geothermal unit in Germansville, PA and the surrounding Greater Lehigh Valley area, we know you have a lot of companies to choose from. When you choose Jack Lehr Heating, Cooling & Electric, you'll benefit from our:
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- And more!
For all of your residential cooling needs in Germansville and the Greater Lehigh Valley area, call the experts at Jack Lehr to schedule service or request a free system replacement estimate.
We look forward to serving you!
Local Reviews
for Germansville, PA
Great heating preventative maintenance
Scott - Germansville, PA
Great service. No problems
Paul - Germansville, PA
Performed residential maintenance
Performed residential maintenance
Performed electrical maintenance
Performed residential maintenance
Performed residential maintenance
Performed electrical maintenance


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They are, however, maintaining their heading towards what they hope turns out to be a Canadian men's curling championship.
"I don't believe in any destiny or anything special." said Gushue Friday night after Newfoundland once again booked its place in Sunday's Tim Hortons Brier final with a 7-5 win over Mike McEwen's Manitoba entry.
"(But) we can make all the shots that we call. (Tonight), we made a heck of a lot of them. Hopefully, we do the same thing on Sunday."
This will be the second straight Brier final for Gushue and teammates Mark Nichols, Brett Gallant and Geoff Walker. Last year, in Ottawa, they lost to Kevin Koe.
Manitoba and Newfoundland had finished on top of the 2017 Brier round-robin standings with 9-2 records, although the McEwen rink took first place by virtue of an 8-4 win in their head-to-head game. That provided last-rock advantage in the 1-2 Page Playoff game, but after forcing Manitoba to a single in the opening end, Gushue and Co. kept dictating the course of the game, wielding their own hammers with impunity.
"That was our best game all week," Gushue agreed. "We controlled it right from the get-go. We didn't make any mistakes … just a lot of good shots."
McEwen, B.J. Neufeld, Matt Wozniak and Denni Neufeld can still find themselves in Sunday's championship game, but will have to take an indirect route through tonight's semifinal (8 p.m.) at Mile One. They'll face the winner of a 3 p.m. matchup between Northern Ontario and Team Canada.
Koe's defending champions and Brad Jacobs' 2013 Brier winners finished third and fourth, respectively, in the round robin with 8-3 records.
Gushue said there isn't one of the three other remaining teams that he would prefer to play or avoid on Sunday as he looks to skip Newfoundland to its second Brier title and first in 41 years.
"I just hope a guy doesn't curl as well against us as Kevin Koe did last year," he said, but agreed the 2016 experience will help and that his team should be more relaxed this time.
"We're ready. I really believe we're ready."
They looked ready Friday, too, shooting 94 per cent as a team, with the skip just slightly better at 95. It made it tough for Manitoba to get any traction.
"We threw a lot of quality shots, but the margin of error was so small (because of) how well they were playing," said McEwen. "We would have to be very close to perfect to beat them."
Newfoundland took the lead in the second end by scoring two and never looked back. It could even have qualified as a turning point — Gushue was that much in control on this night — but most observers would probably point to the seventh end. That's when McEwen tried to break up a pile after a fine hit-and-roll by Gushue, but ended up spilling his shots a little too far. Instead of scoring two points to tie the game, Manitoba gave up a steal and Newfoundland had a margin that was too much to erase.
"It was looking like a real good chance to tie it up," McEwen said. "(Gushue's) roll, you couldn't have taken his rock and placed it there by hand any better. He made an absolutely perfect shot. We … played a shot we thought was there and it turned out it wasn't."
As was the case Thursday night when Gushue beat Koe in a round-robin draw, Mile One was packed and loud on Friday. And while the hometown team was in a groove on the ice, so were the fans in the stands, whose repertoire on this evening included a rousing "Sweet Caroline."
"After the game, to see the amount of fans that stuck around for a couple of songs, it was pretty cool. It was a great atmosphere," who in his 14th Brier, is relishing what's so far been an exciting ride.
"Someone asked me how does this compare to the Olympics (when he won in 2006) and I said it's probably just as good or as better just because I'm older and I appreciate it more.
"When I was 25, I thought I was going to win a bunch of these, but I've realized its a harder game over the last number of the years."
Gushue, who has been dealing with a hip/groin injury that sidelined him the first part of this curling season, said he will be in for "lots of rehab" during a well-earned day off. So, apparently, will other members of his team.
"We're a hurtin' unit right now. Geoff's in a little bit of discomfort and we'll get some rest and be ready for Sunday," Gushue said.
What he won't be doing is watching either of today's playoff games in person or on TV.
"I'm going to spend time with my family," said the 36-year-old father of two, adding it's been "kind of a tease" seeing them in a box at Mile One this week while he's been so focused on his games.
"I won't watch any curling. I haven't watched any shots this week. I'll find out probably Sunday morning who won and be ready to go."
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Rock on: Gushue, Newfoundland one win away from elusive Brier title
It's been a rock concert atmosphere at Mile Once Centre the last couple of nights, but Brad Gushue insists he and his Newfoundland and Labrador teammate aren't on some sort of magical mystery tour.
They are, however, maintaining their heading towards what they hope turns out to be a Canadian men's curling championship.

subset: commoncrawl


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Ark: Survival Evolved Taming Calculator
Ark: Survival Evolved Taming Calculator
248 points Taming & KO
The best way to tame an allo is to find the level that you would like and kill off the rest of it's group but if u want all three just get to some high ground and then just start shooting them with tranqs
More Allosaurus Taming & KO Tips
2248 points Taming & KO
Useful tip, don't lead the allosaurus' into another pack. Right now there is a pack of 15 allosaurus' out the front of my base.
1698 points Taming & KO
If you have a group of 3 or more tamed then the highest level will become an alpha which will give it a new attack and bleed effect.
1516 points Taming & KO
It takes more arrows than this app tells you
584 points Taming & KO
dodo is better
580 points Taming & KO
if u are going for an allosaures tame the easiest thing you can do is lead one into a taming pen and then kill the others outside that way they do not have the alpha pack boost affect and you can easily and safely knock it out


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simonshack 4 Oct 19 2010, 11:37 PM wrote:And I'll say one more thing: If you don't get this, you are not going to be a credible member of this forum.
Jazza 4 Oct 20 2010, 03:45 AM wrote:The chief 52 on his helmet is a Photoshop mess. It's blurry, and the angle is just wrong.
It's been almost a year since that terrible day when you were taken from us.
It's hard to believe that a year has gone by since your tragic death
nonhocapito 4 Oct 20 2010, 12:07 AM wrote:
I know you probably have discussed this a hundred times Simon, but some of us haven't yet (I haven't) and because one person cannot figure out everything by himself, and the material on this forum or elsewhere is quite vast to be taken all in (it must happen over time, over years of research), maybe there is no need to question the "credibility" of people for this (well, it's your call, of course).
reel.deal 4 Oct 21 2010, 10:41 AM wrote:
edit: it seems david copperfield turned up and actually sawed wtc 4 in half, then 'vanished' it, so have withdrawn my own 'mock-up' clone-stamp wtc4 version. oops! damn! i should have guessed...
Return to SEPTEMBER CLUES: the 9/11 psyop exposed: the media aired a "Made-for-TV Hollywood movie"
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Carpet Cleaning Frankston – We are team awesome Carpet Cleaners and focus on customers 100% satisfaction guaranteed. We deliver the best carpet cleaning services all across Frankston. Our technicians are equipped with the latest tools and possess the right skills to restore your carpet and make them look new once again. Our carpet cleaning services include carpet steam cleaning, carpet stain removal, carpet shampooing, carpet deodorising, carpet sanitising, carpet stain removal, carpet Scotchgard, carpet dry cleaning, carpet repair, carpet mould restoration, pet hair removal from carpet, pet stain and odour removal from carpet, Carpet repair and re-installation and more.
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Our Carpet Cleaning Technician at work
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Our Office Location in Frankston
Location: Frankston, VIC, Australia


text: When I was little, my favorite Christmas tradition was making paper chains with my dad. Ripping off a link every night before bed was so very exciting to 5-year-old me. Now that my son is old enough to understand the anticipation of season, I'm excited to start our own tradition […] Read More »


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Hearing scheduled to address Torrington's concerns about proposed methadone clinic
TORRINGTON >> Public discussion will continue Wednesday regarding the proposed methadone clinic at 241 Kennedy Drive, and with it, officials representing Hartford Dispensary will have to answer questions posed by city personnel and their concerns with the possible clinic.
The Torrington Health and Recovery Center proposal's public hearing began on Sept. 12 and was continued until Wednesday at 7 p.m. in City Hall's auditorium during the Planning and Zoning Commission's meeting.
After passing through the Inlands and Wetlands Commission with understanding that it will receive a "favorable report" from Torrington's engineering department, the proposed methadone clinic's representation will be targeted with questions outlined in a memorandum from City Planner Martin Connor, detailing different requirements and concerns from around city hall and beyond.
The legal representative for Hartford Dispensary told Connor she plans on addressing Water Pollution Control Authority and Torrington Fire Department requests.
Acting Fire Chief Gary Brunoli outlined the need for the Torrington Health and Recovery Center to be compliant with a fire protection system, the need to include a secure lock box at the building's exterior for quick, after-hours access by fire officials, and to follow fire marshal regulations.
WPCA said the non-profit must adhere to sewer guidelines and develop and prove a management plan for its spent pharmaceutical products.
The zoning board did have some concerns over parking -- only 14 car spots are on the current plan, and with six employees and an estimated 125 patients per day, the plan needs tweaking. Parking on Kennedy Drive is prohibited and the current building doesn't meet specific setback regulations from neighboring Alvord Park.
Economic Development Director Rose Ponte, in Connor's memo, had the same concerns.
"I have concerns related to traffic and parking availability in the area, and don't believe this is an appropriate location for this use," Ponte said. Parking concerns and traffic volume, she said, might impact Kennedy Drive.
Traffic officials at Torrington Police Department suggested traffic signals at the intersection of Kennedy Drive and Torringford West need an upgrade. The current roadwork near the intersection has nothing to do with the proposal, officials said.
The zoning commission will "need to make a finding for that the location of this proposed facility is compatible with the neighborhood in terms of traffic, noise, illumination and number of patients/ clients served," the memo states.
Reach Ricky Campbell at 860-489-3121 x343 and subscribe to posts at Facebook.com/RickyCampbell25


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UBS news
UBS reports first quarter net profit of CHF 1,214 million
UBS reports net profit of CHF 1,214 million in first quarter 2003, down 11% from the same quarter a year earlier. Before goodwill and excluding the net gain from the sale of Hyposwiss in first quarter 2002, net profit was 7% lower. Despite tough markets, UBS managed to increase shareholder returns by keeping a strong grip on costs and managing capital resources tightly. UBS's wealth management businesses (Private Banking and UBS PaineWebber) achieved strong net new money inflows of CHF 11.1 billion, with a record inflow into the European wealth management initiative.
UBS reports net profit of CHF 1,214 million, a decline of 11% from the first quarter a year earlier. Before goodwill and excluding the gain from the sale of Hyposwiss in first quarter 2002*, net profit was 7% lower. This decrease is almost entirely attributable to currency moves - mainly the US dollar's 20% weakening against the Swiss franc between the two periods.
Compared to fourth quarter 2002 and before goodwill, net profit rose 35% after excluding the writedown related to the withdrawal of the PaineWebber brand** and the gain from the sale of Klinik Hirslanden***.
"UBS has again delivered robust results in a tough environment. We focused on protecting and enhancing returns for our shareholders. We pushed down our cost/income ratio to its lowest level since the middle of 2001, and delivered a higher return on equity than this time last year," said Peter Wuffli, President of the Group Executive Board.
About half of the change in both income and expense compared to the same quarter a year earlier was driven by currency movements.
Operating income declined 19% compared to a year earlier. Adjusted for the gain from the sale of Hyposwiss1, income was 18% lower. Apart from the currency effects, the decrease was mainly due to poor equities trading conditions and low equity market levels, affecting asset-based revenues. Encouragingly, private equity writedowns at UBS Capital returned to more moderate levels, decreasing to CHF 123 million in first quarter 2003 from CHF 383 million in the same quarter a year earlier. Fixed income trading revenues were very strong, reflecting a buoyant trading environment that benefited from low interest rates and a steep yield curve.
Credit businesses again proved resilient, despite another quarter of generally weak economic conditions. Actual net credit loss expense during the quarter amounted to CHF 104 million compared to CHF 85 million in the same quarter in 2002.
Costs remained under tight control. Operating expenses fell 20% from the same quarter a year earlier, to their lowest level since the merger with PaineWebber. Besides currency effects, the decrease reflects sharp declines in personnel and in general and administrative expenses, down 21% and 18% respectively. Performance-related compensation also fell.
Headcount declined a further 666 to 68,395 in the three months since 31 December 2002 as processes and structures were streamlined. At the same time, capabilities were selectively expanded in areas with growth potential.
Net new money in UBS's wealth management businesses (Private Banking and UBS PaineWebber) for the quarter was CHF 11.1 billion - a strong result that shows the continued confidence clients place in UBS's financial advice, its stability and strength. In the European wealth management business, net inflows reached a record of CHF 3.0 billion. Inflows were positive across all private banking markets. In the US, UBS PaineWebber reported net new money of CHF 3.7 billion, comparing favorably to industry experience.
Merger of Cantrade, Bank Ehinger and Armand von Ernst
On 18 February 2003, UBS announced the creation of a holding company for its five fully owned independent private banking subsidiaries and GAM, its specialist asset manager.
The three Swiss-German private banking subsidiaries (Berne-based Armand von Ernst, Basel's Bank Ehinger and Zurich's Cantrade) are now merging under the name Ehinger & Armand von Ernst. The merger is legally retroactive to 1 January 2003 and full operational integration of the three banks is expected to be complete by 1 January 2004. The new bank, headquartered in Zurich, with branches in Basel and Berne, will be one of the most important providers of private banking services in the Swiss-German speaking regions of Switzerland.
GAM, Ferrier Lullin in Geneva and Banco di Lugano are not affected by the merger and will continue to service their clients under their present brands.
Outlook 2003
Markets and trading conditions are tough and will likely remain so.
"While some further degree of volatility cannot be excluded, we do feel that the downward pressure on our industry from the business and market environment could be beginning to ease and that the worst earnings declines may be behind us," Peter Wuffli said. "Our businesses are proving highly competitive and we remain convinced that our strategy is the right one."
Although the timing of a return to sustained revenue growth is hard to predict, UBS is still in a position to protect and enhance shareholder returns by flexing costs and tightly managing capital. At the same time, because of its successful strategic initiatives, UBS continues to be well placed to profit from growth opportunities as they arise.
Financial ratios as reported
Annualized return on equity in first quarter 2003 was 13.2%, compared to 12.3% a year earlier. Basic earnings per share were CHF 1.05 in first quarter, against CHF 1.10 in the same quarter a year earlier. The cost/income ratio was 78.4% in first quarter 2003, down from 80.1% a year earlier.
Performance against Group financial targets
(pre-goodwill and adjusted for significant financial events****)
UBS management sets the Group's financial targets and evaluates performance in terms of adjusted results, excluding significant financial events and the amortization of goodwill and other intangibles. On that basis, UBS's performance against financial targets shows:
The Group's annualized return on equity for first quarter 2003 was 15.8%, up from 15.2% in the same quarter a year ago and back within our target range of 15-20%. The ongoing reduction of equity through share buyback programs more than offset the market-related decline in earnings.
Basic earnings per share in first quarter 2003 were CHF 1.26, just below CHF 1.27 in the same quarter last year. The 7% decline in profit was again offset by the reduced average number of shares outstanding, driven by ongoing share buyback programs.
The cost/income ratio this quarter was 75.3%, a decrease from 77.9% in first quarter last year and the lowest since second quarter 2001, as tight cost control complemented the fall in private equity writedowns.
Results from the Business Groups
UBS Wealth Management & Business Banking
Private Banking's pre-tax profit in first quarter 2003 was CHF 534 million, up 7% from fourth quarter 2002, as performance benefited from lower running costs. Net new money in first quarter 2003 was CHF 7.4 billion, up from CHF 2.8 billion in the previous quarter, the third strongest quarter since 2000. Private Banking - International Clients reported CHF 7.0 billion in net new money, with a record inflow into the European wealth management initiative. The gross margin on invested assets increased slightly to 98 basis points in first quarter from 97 basis points in fourth quarter 2002.
Business Banking Switzerland reported its third-highest quarterly pre-tax profit ever, CHF 499 million, a 10% increase from fourth quarter 2002. Revenues rose slightly due to higher interest income, while costs fell to a record low, mainly due to lower depreciation and personnel expenses. Actual credit loss expense amounted to CHF 64 million in first quarter, on par with the CHF 60 million in fourth quarter. The relatively low level of credit losses in Switzerland despite a deteriorating economic climate reflects the results of UBS's efforts to improve the quality of the domestic credit portfolio. Helped by growth in the Swiss residential mortgage lending business, the loan book of UBS Wealth Management & Business Banking increased by CHF 2.9 billion or 1.7% between 31 December 2002 and 31 March 2003.
UBS Global Asset Management
Pre-tax profit for first quarter 2003 was CHF 44 million, an increase of 29% from fourth quarter 2002. This was the result of lower operating expenses, down mainly because the fourth quarter 2002 result included severance costs and expenses for unoccupied premises. Partially offsetting the falling operating expenses were a decline in institutional performance fees and lower revenues at O'Connor.
In the Institutional business, net new money totaled CHF 3.9 billion in first quarter 2003, compared to CHF 2.4 billion in fourth quarter 2002. Equity mandates experienced strong inflows globally. In its Wholesale Intermediary fund business, UBS Global Asset Management recorded a net inflow of CHF 3.4 billion in first quarter 2003, compared to negative CHF 0.8 billion in fourth quarter 2002.
Invested assets for UBS Global Asset Management totaled CHF 519 billion at 31 March 2003 (CHF 533 billion at 31 December 2002). Most of UBS Global Asset Management's funds continued to show a strong relative investment performance over 1-year, 3-year and 5-year periods.
UBS Warburg
UBS Warburg's Corporate and Institutional Clients business unit recorded a pre-tax profit of CHF 894 million in first quarter 2003, down 6% from the same period last year, but 72% higher than fourth quarter 2002. The decrease from last year was largely due to currency movements, with the US dollar falling 20% against the Swiss franc in the period.
Income was CHF 3,341 million in first quarter, down 20% from the same quarter last year, but up 17% from fourth quarter 2002. The Fixed Income, Rates and Currencies business reported its best performance since 1999, rising 4% from a year earlier and up 100% from the last quarter. The revenues in this business are mostly denominated in US dollars - and results would have been even more favorable without the negative impact of the falling US dollar. Investment Banking revenues decreased 44% from the same quarter last year due to the negative impact of market and economic conditions on the corporate client fee pool. Income from the Equities business also declined 45% compared to a year ago due to lower market activity affecting trading opportunities as well as lower proprietary trading revenues. Client commissions held steady.
In contrast to general market trends, UBS Warburg continued to weather the difficult credit environment well, with few new impairments this quarter. The non-performing loans to gross loan ratio was almost steady at 1.7% in first quarter 2003 against 1.6% in fourth quarter 2002.
Operating expenses in first quarter 2003 dropped by 24% from first quarter 2002 but increased 4% from the previous quarter. The compensation ratio fell to 54% for the quarter, compared to 55% for the full year 2002. The elasticity of this unit's cost base allows UBS Warburg to closely manage expenses in line with revenues.
UBS Capital recorded a pre-tax loss of CHF 90 million in first quarter 2003. This compares favorably to pre-tax losses of CHF 362 million in fourth quarter 2002 and CHF 462 million in first quarter 2002, mainly a reflection of lower writedowns. Unfunded commitments fell from CHF 2.1 billion on 31 December 2002 to CHF 1.9 billion on 31 March 2003.
UBS Capital will continue to focus on managing existing assets in order to maximize value. It will also pursue opportunities to reduce undrawn capital commitments.
Prevailing economic conditions, however, will continue to determine UBS Capital's financial performance, with its results expected to remain volatile due to the unpredictability of exit opportunities. However, there are signs that the remaining portfolio is trending towards a performance more in line with overall equity markets.
UBS PaineWebber
Despite continued investor pessimism, with sentiment at a historic low in first quarter, UBS PaineWebber posted a solid performance and achieved strong net new money of CHF 3.7 billion, demonstrating its competitive strength.
Including acquisition costs, UBS PaineWebber reported a pre-tax loss of CHF 95 million, compared to a loss of CHF 1,368 million in fourth quarter 2002 when the withdrawal of the PaineWebber brand required an amortization expense of CHF 1,234 million. Excluding the writedown and other acquisition costs (goodwill amortization, net funding costs and retention payments), the Business Group posted a pre-tax operating profit of CHF 120 million, down from CHF 142 million in fourth quarter 2002.
Since UBS PaineWebber's transactions are primarily denominated in US dollars, comparisons of its results to prior periods are affected by the decline of the US dollar against the Swiss franc. In US dollar terms, performance before tax and acquisition costs was 10% lower than in fourth quarter 2002, reflecting essentially flat revenues but slightly higher personnel expenses.
Zurich / Basel, 13 May 2003


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Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00742625
Recruitment Status : Completed
First Posted : August 28, 2008
Results First Posted : February 5, 2013
Last Update Posted : September 12, 2014
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Acute Myeloid Leukemia Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Untreated Adult Acute Myeloid Leukemia
|Drug: daunorubicin hydrochloride Drug: cytarabine Drug: bortezomib
|Phase 1 Phase 2
I. To define the remission induction response rate (complete response [CR] and CR with incomplete platelet recovery [CRp]) in older patients with previously untreated acute myeloid leukemia treated with induction therapy comprising bortezomib in combination with daunorubicin hydrochloride and cytarabine.
II. To define the maximum tolerated dose of bortezomib when administered in combination with intermediate-dose cytarabine after induction therapy.
I. To describe the disease-free survival of patients treated with this regimen. II. To describe the overall survival of patients treated with this regimen. III. To evaluate the treatment-related toxicities in these patients.
OUTLINE: This is a multicenter, dose-escalation study of bortezomib. Doses of bortezomib are escalated during remission consolidation therapy.
REMISSION INDUCTION THERAPY: Remission induction course 1: Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11; daunorubicin hydrochloride IV on days 1-3; and cytarabine IV continuously over 168 hours on days 1-7.
After completion of remission induction course 1, patients undergo bone marrow aspiration and biopsy for evaluation of response. Patients achieving a complete response (CR) or partial response (PR) proceed to remission consolidation therapy. Patients achieving a CR with incomplete platelet recovery (CRp) proceed to remission consolidation therapy after platelet counts recover. Patients with persistent leukemia (>= 20% bone marrow cellularity and >= 5% bone marrow myeloblasts) proceed to remission induction course 2.
REMISSION INDUCTION COURSE 2: Patients receive bortezomib IV over 3-5 seconds on days 1 and 4; daunorubicin hydrochloride IV on days 1 and 2; and cytarabine IV continuously over 120 hours on days 1-5.
After completion of remission induction course 2, patients undergo bone marrow aspiration and biopsy for evaluation of response. Patients achieving a CR or PR proceed to remission consolidation therapy. Patients achieving a CRp proceed to remission consolidation therapy after platelet counts recover. Patients with residual leukemia who do not meet the criteria for PR are removed from the study.
REMISSION CONSOLIDATION THERAPY: Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11 and intermediate-dose cytarabine IV over 3 hours on days 1-5. Patients then undergo bone marrow aspiration and biopsy for evaluation of response. Patients achieving a CR or who demonstrate continuing CR receive a second course of remission consolidation therapy beginning 2-4 weeks after blood counts recover.
After completion of study therapy, patients are followed every 2 months for 2 years, every 3 months for 2 years, and then annually for up to 10 years.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|95 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Dose Escalation and Phase II Study of Bortezomib (IND #58443) Added to Standard Daunorubicin and Cytarabine Therapy for Patients With Previously Untreated Acute Myeloid Leukemia Age 60-75 Years
|Study Start Date :
|September 2008
|Actual Primary Completion Date :
|July 2010
|Actual Study Completion Date :
|December 2012
Experimental: Treatment (daunorubicin hydrochloride and bortezomib)
See Detailed Description
Drug: daunorubicin hydrochloride
Given IV
Other Names:
Drug: cytarabine
Given IV
Other Names:
Drug: bortezomib
Given IV
Other Names:
- Remission Induction Response [ Time Frame: 2 months ]
Response was calculated according to Revised International Working Group (IWG) criteria for Acute myeloid leukemia (AML)
A response was defined as the portion of participants who achieved a complete response (CR) or CR with incomplete platelet recovery(CRp) during induction.
A CR is defined as those with > 20% cellularity of bone marrow biopsy, no presence of extramedullary leukemia for AML, <5 % myeloblast cells for bone marrow with peripheral blood and normal complete blood count (absolute neutrophils > 1000 mL and platelets >= 100,000 mL).
A CRp is defined as a CR except platelets < 100,000 mL without need for transfusion.
- Participants Experiencing a Dose-limiting Toxicity (DLT) of Bortezomib When Administered in Combination With Intermediate-dose Cytarabine [ Time Frame: during consolidation cycle 1 (42 days) ]
DLTs were considered only during the first cycle of consolidation therapy and included grade 3 or 4 sensory or autonomic neuropathy, persistent grade 4 thrombocytopenia or neutropenia at day 42 in the absence of AML,any grade 4 or 5 nonhematologic toxicity, and any grade 3 nonhematologic toxicity (excluding neuropathy and toxicities secondary to neutropenia and sepsis) that did not resolve to grade 2 by day 42 unless attributable to persistent or recurrent AML. Grade 4 anorexia (requiring total parenteral nutrition) and grade 4 fatigue (requiring bed rest) were not considered DLTs.
Toxicity was graded per National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. Grading scale is as follows: grade 1: mild; grade 2: moderate; grade 3: Severe; grade 4: Life Threatening; grade 5: Death.
- Disease-free Survival [ Time Frame: Duration of study (up to 10 years) ]Disease-free survival (DFS) was measured as the interval from achievement of CR until relapse or death, regardless of cause. DFS was estimated using the Kaplan Meier method.
- Overall Survival [ Time Frame: Duration of study (up to 10 years) ]Overall survival (OS) as the interval from the on-study date until death. OS was estimated using the Kaplan Meier method.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|60 Years to 75 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Unequivocally histologically confirmed acute myeloid leukemia (AML)
- At least 20% blasts in the bone marrow based on WHO criteria
- No acute promyelocytic leukemia (M3)
- Antecedent hematologic disorder or myelodysplastic syndromes allowed provided the patient did not receive cytotoxic chemotherapy, including azacitidine and decitabine, for their pre-leukemic disorder
- Concurrent enrollment on CALGB-8461 required
- Not pregnant or nursing
- Fertile patients must use effective contraception
- No ataxia, cranial neuropathy, or peripheral neuropathy >= grade 2
- LVEF >= 40% by ECHO or MUGA scan
- No signs or symptoms of congestive heart failure
- DLCO >= 50% (corrected for hemoglobin)
No prior therapy for leukemia or pre-leukemic disorders, except for the following:
- emergency leukapheresis;
- emergency treatment for hyperleukocytosis with hydroxyurea;
- cranial radiotherapy for CNS leukostasis (one dose only);
- growth factor/cytokine support
No other concurrent chemotherapy, except for the following:
- I) steroids administered for adrenal failure, hypersensitivity reactions, or septic shock;
- II) hormones administered for non-disease-related conditions (e.g., insulin for diabetes or estrogens or progestins for gynecologic indications)
- No concurrent palliative radiotherapy
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00742625
|United States, District of Columbia
|Washington Hospital Center
|Washington, District of Columbia, United States, 20010
|Lombardi Comprehensive Cancer Center at Georgetown University
|Washington, District of Columbia, United States, 20057
|United States, Florida
|Florida Hospital
|Orlando, Florida, United States, 32803
|United States, Illinois
|University of Chicago
|Chicago, Illinois, United States, 60637
|United States, Maine
|Eastern Maine Medical Center
|Bangor, Maine, United States, 04401
|United States, Maryland
|University of Maryland/Greenebaum Cancer Center
|Baltimore, Maryland, United States, 21201
|United States, Massachusetts
|Massachusetts General Hospital Cancer Center
|Boston, Massachusetts, United States, 02114
|Brigham and Women's Hospital
|Boston, Massachusetts, United States, 02115
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02115
|United States, Missouri
|University of Missouri - Ellis Fischel
|Columbia, Missouri, United States, 65212
|United States, Nebraska
|University of Nebraska Medical Center
|Omaha, Nebraska, United States, 68198
|United States, New York
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|North Shore University Hospital
|Manhasset, New York, United States, 11030
|North Shore-LIJ Health System CCOP
|Manhasset, New York, United States, 11030
|Long Island Jewish Medical Center
|New Hyde Park, New York, United States, 11040
|North Shore-LIJ Health System/Center for Advanced Medicine
|New Hyde Park, New York, United States, 11040
|Mount Sinai Medical Center
|New York, New York, United States, 10029
|United States, North Carolina
|University of North Carolina
|Chapel Hill, North Carolina, United States, 27599
|Kinston Medical Specialists PA
|Kinston, North Carolina, United States, 28501
|Wake Forest University Health Sciences
|Winston-Salem, North Carolina, United States, 27157
|United States, Ohio
|Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
|Columbus, Ohio, United States, 43210
|United States, Virginia
|Virginia Commonwealth University
|Richmond, Virginia, United States, 23298
|Principal Investigator:
|Eyal Attar
|Cancer and Leukemia Group B
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00742625 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
NCI-2009-00443 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
CALGB 10502 ( Other Identifier: Cancer and Leukemia Group B )
CALGB-10502 ( Other Identifier: CTEP )
U10CA031946 ( U.S. NIH Grant/Contract )
P30CA014236 ( U.S. NIH Grant/Contract )
|First Posted:
|August 28, 2008 Key Record Dates
|Results First Posted:
|February 5, 2013
|Last Update Posted:
|September 12, 2014
|Last Verified:
|June 2014
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Leukemia, Monocytic, Acute
Leukemia, Myelomonocytic, Acute
Leukemia, Megakaryoblastic, Acute
Leukemia, Erythroblastic, Acute
Neoplasms by Histologic Type
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Antineoplastic Agents
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antibiotics, Antineoplastic
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors


text:
Dwellings is indexed without sub-indicators when the data refers to the total number of dwellings in a region. These tables appear first in the search results list below.
ArcticStat places no restriction on its use and all tables may be freely downloaded, but its users are requested to reference it as a source.
Recommended citation : [Reference to the table]*, found in ArcticStat, www.arcticstat.org, on
By accepting the terms of agreement for this table, you are automatically accepting these terms for all the tables you will consult in the current session.
* Following the editorial standards or citation requirements of the statistical agency or publishing house.


text:
News tagged with creativity
Creativity refers to the phenomenon whereby a person creates something new (a product, a solution, a work of art, a novel, a joke, etc.) that has some kind of value. What counts as "new" may be in reference to the individual creator, or to the society or domain within which the novelty occurs. What counts as "valuable" is similarly defined in a variety of ways.
Scholarly interest in creativity ranges widely: Topics to which it is relevant include the relationship between creativity and general intelligence; the mental and neurological processes associated with creative activity; the relationship between personality type and creative ability; the relationship between creativity and mental health; the potential for fostering creativity through education and training, especially as augmented by technology; and the application of an individual's existing creative resources to improve the effectiveness of learning processes and of the teaching processes tailored to them.
Creativity and creative acts are therefore studied across several disciplines - psychology, cognitive science, education, philosophy (particularly philosophy of science), technology, theology, sociology, linguistics, business studies, and economics. As a result, there are a multitude of definitions and approaches.
This text uses material from Wikipedia, licensed under CC BY-SA


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A wake-up call for Wall Street
In response to "Trust concerns follow tweet" (Business, April 25): When the Dow took a 143-point plunge on Tuesday based on an unsubstantiated rumor, our public stock markets were severely compromised and damaged. This should be a wake-up call for the SEC and our government because this was a graphic demonstration of how high-frequency traders using computer algorithms can read headlines, create automatic orders and sell thousands of different stocks before human beings know what has happened and can react to correct the mistake. What if this episode was not a rumor mistake but a Wall Street strategy to make short-selling profits?
This is not about banning computers, but it's about protection and securing our capital markets. These computer algorithms are so powerful that they could bring down our capital markets before humans and/or circuit breakers had a chance to stop them.
We obviously need immediate action to protect our capitalistic system from cyberespionage and terrorism and be able to guarantee the public that their investments and savings are safe from computer programs that now can be compromised and manipulated. — Cliff Lindroth, San Diego
Don't rush to apply education reforms
The op-ed article by Margaret Spellings, "Breaking monopoly of mediocrity in our schools" (Opinion, April 25), like many others the U-T has published on this subject, says our schools are doing a poor job of educating students and proposes some remedies that should be applied to all schools. The evidence that our schools are mediocre is that many students obtain relatively low scores on reading and math tests and that there are differences in the average scores of various racial and ethnic groups. Others also often cite the fact that students in some other countries, usually smaller and more homogeneous than the U.S., obtain higher scores on average than do American students.
There are large individual differences in cognitive ability, as in all human traits, so it is not surprising that about half the students score below average. There is disagreement among scientists about the cause of the achievement gap, but it is large and has changed little over the past 50 years in spite of valiant attempts to reduce it. Thus, Spellings' claim that "with a good education, every child, everywhere, can realize success" seems difficult to achieve if success is defined as being above average.
Spellings' suggestions for raising student achievement seem reasonable as do others concerning better teachers and early childhood education, but these and other promising ideas have not been very successful in increasing student achievement in the past. In 2010 in the U.S there were 55.2 million students taught by 3.8 million teachers in 132,656 schools. It is not a good idea to impose unproven changes on this massive system. What are needed are well-designed studies to see what works. The FDA requires that a new drug be shown to be safe and effective in clinical trials before it is released to the public. The Department of Education should have a similar requirement for educational programs. — Bob Nichols, Jamul
Give students an employable skill
Your front-page article on high school graduation requirements ("Students in for a tough test," April 25) missed the point.
The significant point is that the A-G college entrance requirements are the wrong goal for the supermajority of students. Nationally, 30 percent of high school students go on to graduate from a university. In urban districts, like San Diego and Sweetwater, the proportion is substantially smaller. Requirements like these only push up the already enormous high school dropout rate.
A far better question for your paper and the school boards is what proportion of their students obtain an employable skill? An even better question is do the school boards have a system to collect data on employability of their students? An let us not forget the 2.5 million in prison and 4.5 million on probation and parole, 70 percent of whom are high school dropouts. — James C. Wilson, Ed.D., Scripps Ranch
Keep government hands off the Internet
"Internet doesn't need more rules" (Business, April 18) only goes halfway toward explaining the problem with further U.S. government intrusion at the FCC. The last thing we need is for professor Susan Crawford from left-laced Harvard University to become chairwoman of the Federal Communications Commission and put in place her idea to regulate all Internet practices and profits. What a perfect opportunity to stifle Obama's outright critics and shut down the lights on horrendous government inefficiencies and corruption. With CBS, NBC, ABC safely tucked under this administration's wing, the Internet and Fox News are the only places to go to get even an inkling of the truth. — Nicholas Waln, Temecula
The immigration challenge
In response to "Boston terror: no immigration story" (Opinion, April 25): Recently on a Bakersfield TV station, there was an advertisement showing two young Mexican children (5 to 8 years old) stating that, they wanted to learn English, so that they could go to college. The advertisement was funded by a politician looking for more educational funding. Needless to say, new immigrants were not being asked to fund this expanded education program.
To me, the immigration challenge is more of one of educating the next generation of immigrant children. Indications are of limited involvement from immigrant parents, high dropout rates of their children and the issue of Mexican youth gangs. All of these factors will contribute to a decline in the quality of life for the next generation of all Americans.
Without strong parental support of education, the system is doomed. I see no indication of this level of support from the immigrant parental community (nor the nonimmigrant parental community as well). More educational funding is a waste of money until parental involvement greatly improves. — Dan Dreblow, Carlsbad
The Republicans are reluctant to pass any immigration bill which would give any status to the illegals so they would be encouraged to vote, which many of them already do. If the new legislation provided that if any noncitizen ever voted at any time in a public election they would be subject to immediate deportion and never permitted entry back into the U.S., I bet the Dems would go bananas over such a proposal because they rely on the illegal vote. — Martin I. Jackson, Fallbrook
It is sad to see that Ruben Navarrette has joined the "blame America" movement to explain the actions of the Boston terrorists. In order to do this, Ruben ignores the intelligence supplied by the Russians, the six-month trip to Russia and surrounding states by the older brother and the sophisticated construction of the elements of mass destruction, including the suicide vest.
In historical context he ignores the action by our government after the terrorists acts committed by the anarchists in the early 20th century. He also has failed to include the effective action taken by the Mexican drug cartels to establish criminal connections in the U.S. The cartels are so brazen that members of the cartels have been caught tending marijuana farms in the remote areas of California. A couple of innocent American hikers lost their lives as a result.
I would hope that Ruben would observe the very sensible advice followed by many opinion makers: "If you don't have anything to add to the discussion it is best to keep your mouth shut." By writing the current opinion piece, Ruben has validated all the issues I have criticized him for and shown him willing to accept illegals no matter how much he protests. — Jim Reid, Pacific Beach
Markets' data could be box score
I read that you dropped stock prices in the Business section (Note to our readers," Business, April 23). Why can't you put in a small box the top ten active stocks and commodities, like a baseball box score? — Peter L. Rosenberg, Maverick Tees Inc., Vista
Comics, beer are economic engines
The story "Beer's economic bonanza" (Business, April 24) creates a false comparison between San Diego Comic-Con International and the San Diego craft beer industry sector.
As an attendee and volunteer of SDCC and consumer of San Diego-made craft beer, I am a fan of both. However, SDCC lasts all of five days, if we include Wednesday's preview night; the craft beer industry operates year-round, which culminates with the 10-day (or so)-long San Diego Beer Week. If SDCC was a longer event and not limited by the max capacity of the convention center, SDCC would have a larger impact within that short five-day period.
The U-T shouldn't write the article as an either-or context, but should say that both are important economic engines in our region and their continued prosperity should be supported. — James Udan, Chula Vista
Internet sales tax compliance would be impossible
I certainly hope House Republicans are able to thwart the passage of the so-called Marketplace Fairness Act, the bill to make all online merchandise sales subject to the sales tax rate in effect at the shipping address ("Bill to tax Internet sales expected to pass Senate," April 23).
If enacted, this law would require every online retailer in America to know that the sales tax rate in La Mesa is not the same as the rate is in El Cajon, which is not the same as the rate is in Santee. This is repeated over and over again in 9,600 separate and distinct taxing districts throughout America, each with its own tax rate.
It would require every online retailer in the United States to establish an account with 45 different state boards of equalization (five states don't have a sales tax) because one can't just remit collected tax money without an accounting. Each quarterly remittance to 45 different states will have to accompanied by an enumerated listing of each sale to residents of that state by city so the state board could send the correct amount to each individual municipality based upon that city's set tax rate.
The bottom line is that this scenario would cause compliance to be impossible for the small-business man. Even attempting compliance would be significantly financially costly to the little guy trying to run a small business. That 27 senators who call themselves Republicans and several alleged Republican governors favor this measure is particularly disquieting.
This "fairness act" is clearly unfair to all small businesses. Oh, and yes, there's that inconvenient 1992 U.S. Supreme Court decision outlawing this practice. — Jerry Hermes, San Carlos
Pitch in for veterans
It was interesting to read of the hefty gift that Irwin and Joan Jacobs donated to establish an engineering campus in New York City ("Jacobses pledge $133M for campus," Business, April 23). They are well-known locally for their support of the arts here in San Diego.
Coincidentally, in the same day's edition of the U-T is an article concerning the plight of the shelter for homeless veterans ("Council mulls funds to keep vets' shelter open," Local reports, April 23). As a veteran, I would be pleased to see the Jacobses' foundation pitch in to help those who have helped us all. — Herman Ackerman, Normal Heights
Look to GOP for sequester theatrics
A couple of months ago when sequestration commenced you editorialized that the Obama administration was fear-mongering when it warned that there would be travel delays ("Obama's destructive demagoguery," Editorial, Feb. 26). Now that the cuts to the FAA are taking effect, causing furloughs of air traffic controllers, you now accuse them of theatrics ("Air delays: obnoxious sequestration theater," Editorial, April 24).
What you fail to acknowledge is the actual law requiring all federal agencies to make across-the-board cuts. An agency like the FAA is almost exclusively labor-intensive so cuts that have to be made are to salaried employees. Requirements of employee notification of furloughs delayed that actual cuts from taking effect, but now we are seeing the consequences (which were foretold) of the sequestration law.
You claim that the Transportation secretary can find another way to handle the cuts so as to not affect air traffic. Wrong. The secretary is not above the law and he has to carry it out the way Congress mandated it.
Far from being clueless, the administration announced what would happen if sequestration took place. This law was universally applauded by the radicals in the Republican Party. John Boehner was ecstatic that he got over 90 percent of what he wanted in the negotiations leading up to the law's passage. Decency and common sense were tossed aside. If you want to make accusations of theatrics, look no further than the Republican Party. — Rob Cohen, San Diego
Is DEA singling out California?
My understanding is that legalization of marijuana violates federal law. So why is it that DEA routinely raids medical marijuana dispensaries in San Diego County ("DEA raids pot dispensary, several indoor gardens," Local, April 24) but ignores users of pot in Colorado and Washington?
I seem to recall that California voters approved the use of marijuana for medical purposes in addition to reducing penalties for personal use of small amounts of pot. Regardless of how one feels about smoking pot it is hypocritical and disrespectful of California voters for the feds to have such a one-sided approach to enforcing federal laws. — Donna Staggs, La Mesa
Drawn to humor
To Steve Breen and all others involved with the contest: I really enjoy thinking up and sending in my suggested captions. I also enjoy reading the wonderful and witty weekly results. Your managing and arrangement of the whole process is terrific. It is far better than the cartoon contests in The New Yorker magazine or USA Today. You have tapped into a mother lode of local humor. Thank you and keep up the excellent work! — Gerald Driessen, San Diego


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Behrooz Afrakhan
Dying YoungHD
IMDb: 5.9
111 min
After she discovers that her boyfriend has betrayed her, Hilary O'Neil is looking for a new start and a new job. She begins to work ...
Country: USA
Actor: Julia Roberts, Campbell Scott, Vincent D'Onofrio, Colleen Dewhurst, David Selby, Ellen Burstyn, Dion Anderson, George Martin, A.J. Johnson, Daniel Beer, Behrooz Afrakhan, Michael Halton, Larry Nash, Alex Trebek, Richard Friedenberg


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The plays of William Shakspeare: In twenty-one volumes. With the corrections and illustrations of various commentators. To which are added notes, Volume 13
J. Nichols and son, 1813
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Sheer draperies for Yoga Studio at W 23rd NYC
We know that sometimes choosing the perfect window treatments is not as easy as it sound. When you come to Alluring Window, though, you have our expert designers at your service. Additionally, because we know how busy your life is, we're always happy to schedule your free consultation appointment to fit your calendar.
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SusanneMarketing necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 97 diseños de 29 diseñadores freelance.
Advantix Systems
Start-up company that has invented a liquid-based technology that cools/cleans/dehumidifies air at 40-60% reduced energy consumption. The HVAC unit is reliable, more efficient and involves processes such as absorption, diffusion, circulation, and integration. Can be used with renewable energy sources too (solar, waste heat). Green energy solution for processing plants, hospitals, public spaces, big box stores, etc.
Commercial and Industrial plant engineers, facility managers, leaders in sustainability for large corporations with air cooling/dehumidifying needs.
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- logo should suggest innovative technology but also a solid, stable organization
- please no cartoon art or stock art
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Bernard Cazeneuve, French minister for European affairs
Issued on: Modified:
Christophe Robeet speaks to Bernard Cazeneuve, France's European Affairs Minister. Mr Cazeneuve has been asked by President Hollande to convince reluctant MPs from the ruling Socialists to ratify the European Fiscal Pact. The vote will take place at the beginning of October. We also discuss Hollande's priorities for Europe. Finally, we debate what action the European Commission should take on genetically modified corn.
With our guest:
- Bernard CAZENEUVE, French minister for European affairs.
Produced by Salima Belhadj
Programme in partnership with the Robert Schuman foundation


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The Collector Base part 4
Walkthrough - The Collector Base part 4
It won't be too long before Samara's barrier runs you headlong into another group of enemies. As Samara will state, this could be an extra-difficult firefight, and she was right. Enemies will run at you from ahead and to your left. There are no Collectors to deal with here per se, though you'll be heavily, heavily inundated with their Husk and Abomination creations. Remember -- Abominations explode when killed, so try to kill them from afar, or better yet, try to lay waste to them when they're around a group of their comrades, since the explosion can damage and kill fellow enemies, as well. The only Collector you have to deal with here is a lone Scion. As you know from past experience, these guys can be a real pain. He'll approach your position slowly-but-surely, so try and do him in before he gets too close for comfort. Also be ready to be overrun by Husks and Abominations, since there are so many of them to kill. Abominations are the bigger threats, so if you have to prioritize who to kill first, you know who to go after first.
As you move forward from here, one thing will become clear -- Samara is running out of juice. The amount of energy she's exerted to keep that biotic barrier up and running is astounding, and she'll need respite soon. Good thing she's going to get the rest she needs, as the entrance to the next area is just ahead. As you approach it, you'll be assailed by random Husks and Abominations, but this time, Samara won't stand still to let you deal with the threat. She needs to keep moving, or the party won't make it to the door in time, and will be quickly overrun by Seeker Swarms. After some scattered fighting and constant movement, you'll reach the corridor that leads to the door into the next area. At this point, another series of cutscenes will take place. Samara has successfully delivered the party through the Seeker Swarm-infested area safely, and now, it's time for the party to regroup.
Your diversionary team will also show up here, and some sad events may occur thereafter. We sent Grunt in as the leader of our diversionary team, and he ended up dying as a result. The choice you made, if it differed, may result in a different outcome. Nonetheless, as the game shows (and as your party is aware), the Collectors are outside of the blast door, attempting to get back in. There's no time to lose; we're almost to where we need to be. But first, Shepard must pick another team to accompany him towards this ship's control room, so feel free to switch it up if you'd like (we stuck with Miranda and Legion). You'll also get the chance to speak with your crew, giving them encouraging words with a Renegade or Paragon persuasion. This is one of your last chances to earn Paragon or Renegade points, so be sure to go through this conversation in a way most aligned with your character's slant. Then, it's time to move out.
Your party will be catapulted off towards a huge chasm on a polygonal platform, which will allow you to cross this pit towards the location you need to access. You've done this before, back when you were on the Collector vessel during the middle of the game, so this shouldn't come as too big of a surprise. As the platform comes to a stop, more, similar platforms will begin to arrive, attaching themselves to your platform. Naturally, these platforms come fully equipped with plenty of enemies, so you're going to have to fight your way from one platform to the next in order to get through this area in one piece. Doing so shouldn't be too difficult for you, though you should remain passive and guarded as you do this. Overtly-aggressive tactics will only serve to get you cut down posthaste, so take your time, use cover wisely, and deal with each wave of enemies as they make themselves seen.
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Limbo. That's the word most people use to describe the state of affairs in a critical part of our economy — housing finance. The government-sponsored enterprises (GSEs), Fannie Mae and Freddie Mac, which were nationalized almost five years ago with the seemingly noble goal of eventually getting rid of them, now back some 90 percent of American mortgages. So much for good riddance!
But talk of reform finally seems close to action. Senator Bob Corker (R-Tenn.) and Senator Mark Warner (D-Va.) have proposed a bipartisan bill called, appropriately enough, Corker-Warner. Meanwhile, the House Financial Services Committee, led by Representative Jeb Hensarling (R-Texas), has produced its own bill, the more grandiosely entitled Protecting American Taxpayers and Homeowners, or PATH Act. Last Tuesday, during a speech in Phoenix, President Barack Obama weighed in. "Private lending should be the backbone of the housing market," the president said. That same day there was also a housing policy forum at the George W. Bush Presidential Center in Texas, where, among others, Hensarling spoke.
Everyone (well, almost everyone) seems to agree with the president: Private lending should be the backbone of the housing market. But just how much private capital does that entail? Hensarling and most of the Republicans think the government should get out of the game entirely. American Enterprise Institute scholar Peter Wallison, a long-time critic of the GSEs, recently wrote a piece in the Wall Street Journal entitled "Competing Visions for the Future of Housing Finance," in which he called any remaining government presence "faux reform."
Corker and Warner (and Obama) want the government somewhat out of the way — but still there as a backstop. Then there's the liberal Democrat wing, personified by Senate Majority Leader Harry Reid (D-Nev.), who announced in a radio interview that he fears Obama's proposal will crimp home ownership. Unfortunately, these stances are too often vague stakeouts of ideological positions about the role of government — and too rarely about the very basic math of housing finance.
Right now, there is about $10 trillion of mortgage-related debt outstanding. Fannie and Freddie securities make up roughly $4.4 trillion — slightly less than half — of that. The largest holder, in turn, of these Fannie and Freddie securities are U.S. commercial banks, which in the first quarter of 2013 held roughly $1.6 trillion of them. Another huge chunk — more than $1 trillion — is held by the Federal Reserve. About the same amount is held by "the rest of the world" — often foreign central banks and sovereign wealth funds — and another chunk about that size is held by mutual funds.
These buyers are often looking for particular things — things that they get because Fannie and Freddie guarantee the timely repayment of principal and interest on their securities. First off, that means the buyers don't have to think about credit risk, but only interest rate risk. Indeed, so-called rates buyers, who arguably supply more than half of the mortgage credit outstanding (it is rates buyers who now purchase GSE securities) not only don't want credit risk, but in some cases — for institutional, legal or regulatory reasons — they can't take it. Therefore, they only want to own mortgages that are backed by Fannie or Freddie.
Among other things, they also want their investment to be liquid, meaning it can be traded easily. By contrast, private-label securities (shorthand for securities that aren't backed by Fannie or Freddie) aren't easily tradeable, because it's complicated to analyze the credit underlying a huge package of mortgages.
Nor are new rules always designed to encourage investment in private-label securities. Under the final Basel III rules that will determine how much capital banks have to hold, banks will have to do their own due diligence, to the satisfaction of their regulator, on mortgage-backed securities that don't have a Fannie or Freddie guarantee in order to determine the appropriate amount of capital that must be held against them. Securities backed by a GSE, on the other hand, automatically get favorable capital treatment.
So in Hensarling's vision, which does not see any role for government in the mortgage market, you basically have to replace the investor base for the $4 trillion-plus in GSE securities with investors who want and can take credit risk, and are willing to invest in a far less liquid instrument. Four trillion dollars is lot of money; in a late 2010 article, CSFB analyst Mahesh Swaminathan estimated that a private-only solution would remove between $3 trillion and $4 trillion of funding from the U.S. mortgage market.
The Corker-Warner bill, to which Obama is closer in spirit, calls for a system where, in essence, mortgages will be bundled up and sold as securities, and private capital will absorb the first 10 percent of losses on those securities. After that, a government guarantee will kick in. But it's not obvious that there's enough capital market demand in the world even for this "first loss" piece. For the entire $4.4 trillion of existing GSE securities to be covered up to 10 percent first loss, you would need $44 billion in capital.
It's also worth thinking about this on a monthly basis. Investors have been buying some $100 billion of Fannie and Freddie mortgage-backed securities a month. Issuance is likely to decline as rates rise, so let's say it's $80 billion a month. So you'd need to sell $8 billion a month in credit risk in order to securitize the entire $80 billion of mortgages.
Another idea is for a new breed of mortgage insurers — existing mortgage insurers mostly insure individual mortgages, not pools — to provide insurance for the pooled securities. If you assume the new insurers had to be capitalized at 10 percent, then they'd need a more manageable $9.6 billion in capital each year.
Those who argue for no government involvement in the housing market say that the current numbers are beside the point. In congressional testimony, Wallison said that the only reason the buyers of GSE paper didn't want to take credit risk was because "these government-backed securities attract investors who do not want to take risks." In his view, there are plenty of other investors who would step forward. After all, the private market finances lots of other stuff.
Others disagree, sometimes violently. A source of mine who is a big investor in GSE securities sniffs, "This is what you would expect to hear from someone who has never bought or sold a bond in his life, or managed according to investment guidelines, or had to defend an investment decision to an investment committee or fund's board of directors. It is a think tank answer to a real world problem. Asset allocations do not change in the way he describes. Dollars that are invested in something with zero credit risk don't get re-allocated into something that has credit risk, at least not in the same size and at the same price."
And then, there are those in the middle, like Mark Zandi of Moody's Analytics. According to the Wall Street Journal, Zandi thinks the capital will be there — but it will come at a higher price. Under the PATH bill, he estimates that mortgage rates would rise significantly and availability would decline. Even under Corker-Warner, he thinks rates would rise. As Journal columnist William A. Galston put it, "There are real trade offs, and the public deserves to know what they are."
But there is another concern. The question isn't just whether private capital would step up, but where it could come from. Remember, right now, U.S. commercial banks own $1.6 trillion of GSE securities. Theoretically, they could step up and own that plus more, all with credit risk. But does that accomplish the stated goal of removing risk from the taxpayer? Well, no: You're just shifting risk from government-sponsored enterprises to government-sponsored banks. And as another source says, "If all the risks in real estate get shoved back into the banking system, the big smart guys will dictate the first time a panic occurs. Do you want Jamie or Lloyd determining who will get bailed out the next time there is a crisis?"
My new favorite quote comes courtesy of Hensarling, who in his prepared remarks for the Dallas forum said, "If, at the end of the day, taxpayers are still on the hook, then I fear all you've done is put Fannie and Freddie in the Federal Witness Protection Program, given them cosmetic surgery and a new identity and released them on an unsuspecting public."
He's right. If mortgage credit risk is shifted into the banking system, taxpayers are still on the hook. Fannie and Freddie may be better hidden — they'll be camouflaged as banks — but they're still lurking out there!
So the conversation, in the end, shouldn't be about competing visions, because vision doesn't have anything to do with how the market works. It should be about this beast (which can trick us into believing it's been tamed) called mortgage credit risk. How much demand for it does a reform plan require? Is that demand likely to materialize, and if so, what is the source? And are the costs, whether they are on the backs of taxpayers or homeowners, acceptable to all of us? It's math, not politics.
Bethany McLean is a contributing editor at Vanity Fair, and co-author with Joe Nocera of "All the Devils are Here: The Hidden History of the Financial Crisis." Her first book, "The Smartest Guys in the Room," co-written with Peter Elkind, became an Academy Award-nominated documentary.
Any opinions expressed here are the author's own.


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Tell us your Bobby Jackson story
Bobby was a warrior protecting Jazz, not so it would stay the same but so that it could grow. Knowing the music to be an expression of African American culture, Bobby used his gifts to elevate both the music and culture to its highest. His passing will leave a void in the Jazz community and for our family.
As we face this challenging time, we're doing our best to wrap our minds around the great big life of our beloved husband, father, brother, friend. Bobby lived life so fully, touching many people around the world. We appreciate the many prayers and messages of condolence that have been shared on Facebook and through email. Please help us by taking time to share a more personal story about Bobby.
These stories will not be published, but will be privately shared with his family and saved for our son, Xavier. My deepest wish is that I will be able to help Xavier through this time and continue his relationship with the many people that shaped Bobby's life.
~ Lisa-Jean Sylvia
A memorial fund has been set up in Bobby's name. Donations for funeral expenses and Xavier's education are greatly appreciated.
By Mail
Bobby Jackson Memorial Fund
KeyBank - Steelyard Commons
3266 Steelyard Drive
Cleveland, Ohio 44109


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Mariana (Age 26)
Kaktovik, AK
About MARIANA :
"I am a 39 year old and i am on an adult website that I post pics to on a weekly basis.
I am looking to find some men, women, or couples from around my area that don't mind having their pic on the word wide web.. And would love to do some XXX pics with me.
Are you interested in helping me spice up my pics?"
Kristi (Age 28)
Kaltag, AK
About KRISTI :
"Single and alone I am very drastically looking for a guy. Apparently vibrators are not the most perfect lovers, even though I have a closet full of them hahah. I love to pamper myself and I have the hottest toys, I even use them at work, (eggs on batteries )…. turn on when no one is looking, I put the radio on so no one does hear that bitch humm hahaha, enjoying myself. But now, I like a man to make me cum. As long as you know how to get a woman off youre the man I'm looking for!"
Corine (Age 28)
Fort Yukon, AK
About CORINE :
"Im a spontaneous San Diego girl, seeking a couple to share my fantasies with. I just like to have fun without any strings attached to it. Seeking a couple between 25 and 35, you dont need to be experienced with threesomes.. I m kinda new to it myself but enjoy things like these. Im very respectfulll, not only about sex.. I dont mind to build up some sexual tension for a couple of weeks ???? Hope to reassure with that and waiting for an invitation to go for drinks or so. bfn"


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AARP thanks Governor Newsom for signing the Age Friendly California Act [AB 1118] into law, making California the first… Read More »
Do you know ways to help keep your aging loved ones from losing money to scams and fraud? We'll share important… Read More »
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The hamlet of Kytes-Hardwick has an eponymous significance to the family. "The family of 'Herdwick,' a branch of the 'Hastangs,' took their name from this place, and some of them are supposed to have resided here. John de Herdwick, in the time of Edward III., held several offices of distinction, and in the first of Richard II. was one of the justices of the peace for the city of Coventry. Another John de Herdwick aided Richmond, afterwards Henry VII., at the battle of Bosworth-Field, and, it is said, by his good conduct as a guide to the army, got the earl the advantage in that fight 'of the ground, winde, and sunne.' The manor, at this period called Herdwick-Grembald, was conveyed by him, in marriage with one of his daughters, to William Dingley." [1]CITATION[CLOSE]
Lewis, Samuel, A Topographical Dictionary of England. Institute of Historical Research, 1848, Print.
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WestJet arriving from Boston, USA
On time
Flight information
Flight number
This flight is also known as:
Delta Airlines
Azores Airlines
Baggage carousel
Estimated arrival
Oct 20, 14:31
Estimated arrival at Terminal 3 is 14:31
Clear customs
The Canada Border Services Agency officers verify documents and review any goods brought into Canada. Self-service kiosks can be used in most cases to streamline the process.
Collect bags
The airline is responsible for delivering checked bags to the carousel.
A porter can carry up to 3 bags for $10/bag, and $2 for each additional item.
Enter Level 3 International Arrivals area
Meeting someone at the airport?
- Parking
- Cell phone waiting lot (up to 45 minutes)
- Map of meeting location
Tim Hortons
Visit this popular Canadian coffeeshop for quick meal options, snacks, treats and hot and cold drinks
Smoke's Poutinerie
Creative variations on poutine, made with fresh, hand-cut fries and squeaky cheese curds.
One Minute Convenience
One Minute Convenience sells food and drinks, travel essentials and over-the-counter items.
Secure Wrap
Securely wrap and protect your luggage in less than 30 seconds at this airport luggage-wrapping station near Check-In.
Excess Baggage
Safely store your bags or coat for a few hours or weeks. Offering parcel delivery and baggage transfers to a hotel.
International Currency Exchange (ICE)
This ICE booth and ATM buys over 100 international currencies and sells several foreign currencies.
International Currency Exchange (ICE)
This ICE booth and ATM buys over 100 international currencies and sells several foreign currencies.
Plaza Premium meet and greet services
This service provides personal assistance to and from the gate for a seamless airport experience.
Baggage carts
Baggage carts are free to use at Pearson. You'll find them at many locations throughout Terminal 3.
Aviation Interfaith Ministry
Reflect, pray or spend some quiet time in the Terminal 3 interfaith centre.
Pet relief area
Travelling with a dog? This pet relief area outside Terminal 3 offers a comfortable space for dogs to relive themselves.
Ice Huts
This photo series looks at ice fishing hut architecture and examines its relationship to site, revealing the creativity and humour with which builders approach hut design.
Leave the airport
- Parking
- Taxis and limos
- Train to city (UP Express)
- Car rentals
- Ride sharing
- Hotel shuttles
- Off-airport parking shuttles
- Public transit buses
- Long-distance transportation
- Train between terminals (Terminal Link)
Flying out of Pearson? Plan ahead with our Departures Guide.


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An 11-year-old boy has been left scarred for life after a dog tore a chunk from his arm in a savage attack.
Yusuf Mayet needed two reconstructive surgeries to repair the gaping wound caused by a Japanese Akita.
He was attacked in Jessop Park in Batley on Wednesday July 23, while playing with his eight-year-old brother Umar and cousin Muhammad, 11.
The dog, which belonged to a neighbour, lunged for Yusuf and dragged him to the ground, before sinking its teeth into his arm.
Neighbours heard Yusuf screaming and rushed to his aid. They beat the dog off with a stick and called the police.
Dad Akil Mayet said: "It was an unprovoked attack.
"The dog went for his neck but he put up his arms to cover his head and it bit him. It could have killed him."
Yusuf was rushed to Pinderfields Hospital for treatment and he was released on Saturday.
Mr Mayet said: "He is doing well but obviously he is traumatised by the whole thing. It will scar him for life.
"We cannot thank the neighbours enough who saved him."
PC Louise Hurst from Batley NPT said: "The dog was not a dangerous breed and had been well secured and muzzled by his owner on his own property.
"This was a freak accident where the animal managed to get out and has sadly bitten the child. The animal was retrieved by its owner who has had it destroyed."