text:
Statin Therapy to Improve Atherosclerosis in HIV Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00965185
Recruitment Status : Completed
First Posted : August 25, 2009
Results First Posted : February 26, 2015
Last Update Posted : December 11, 2017
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Cardiovascular Disease HIV Atherosclerosis Inflammation Statins, HMG-CoA HIV Infections
|Drug: atorvastatin Drug: Placebo
|Not Applicable
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|40 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|Statin Therapy to Improve Inflammation and Atherosclerosis in HIV Patients
|Study Start Date :
|September 2009
|Actual Primary Completion Date :
|January 2014
|Actual Study Completion Date :
|January 2014
Experimental: Atorvastatin
20 mg PO QD for the first 3 months, followed by 40 mg PO QD for the final 9 months.
Drug: atorvastatin
20 mg PO QD for the first 3 months, followed by 40 mg PO QD for the final 9 months.
|Placebo Comparator: placebo
Drug: Placebo
- Coronary and Aortic Plaque Inflammation [ Time Frame: Measured at baseline and 1 year ]12 month change in mean FDG-PET TBR (18-fluorodeoxyglucose positron emission tomography target-to-background ratio)
- Plaque Progression [ Time Frame: Measured at baseline and 1 year ]12 month percent change in plaque volume
- Endothelial Function [ Time Frame: 1 year ]Assessment of endothelial function was to be measured by endothelial vasodilator function.
- Immune Function [ Time Frame: Measured at baseline and 1 year ]12 month change in CD4 T-lymphocytes
- Lipid Profile [ Time Frame: Measured at baseline and 1 year ]12 month change in lipid profile
- C-reactive Protein (CRP) [ Time Frame: Measured at baseline and 1 year ]12 month change in Log CRP concentration
- Adipocytokines [ Time Frame: Measured at baseline and 1 year ]12 month change in IL-6
- Liver Function Tests (LFTs) [ Time Frame: Measured at baseline, 1, 3, 6, 9, and 12 months ]
Number of participants with LFT abnormalities (greater than or equal to 3 times the upper limit of normal).
For reference, the normal ranges for AST and ALT are shown below. Please note that the normal range for ALT at Labcorp changed over the course of the study. AST and ALT elevations were determined based on the normal range at the time the lab test was performed.
ALT: 0-40 IU/L, 0-44 IU/L, or 0-55 IU/L AST: 0-40 IU/L
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion criteria:
- Men and women age 18-60 with previously diagnosed HIV disease
- Subclinical coronary artery disease as defined by presence of one or more plaque on coronary CTA without history of cardiac events or cardiac symptoms and no evidence of critical coronary stenosis. Target to background ratio (TBR) as determined by PET of > 1.6.
- Stable anti-retroviral (ARV) therapy as defined by no changes in ARV regimen for >6 months
- LDL-cholesterol >70 mg/dL and <130 mg/dL
Exclusion criteria:
- History of acute coronary syndrome
- Contraindication to statin therapy
- Current statin use
- AST or ALT two times greater than the upper limit of normal or receiving treatment for active liver disease
- Renal disease or creatinine >1.5 mg/dL (given the risk of contrast nephropathy during CT angiography of the heart)
- Infectious illness within past 3 months
- Contraindication to beta-blocker (including moderate to severe asthma or heart block) or nitroglycerin use as these drugs are given as part of the standard cardiac CT protocol. Previous allergic reaction to beta blocker or nitroglycerin.
- Body weight greater than 300 lbs due to CT scanner table limitations
- Patients with previous allergic reactions to iodine-containing contrast media
- Active illicit drug use
Patients who report any significant radiation exposure over the course of the year prior to randomization. Significant exposure is defined as:
- More than 2 percutaneous coronary interventions (PCI) within 12 months of randomization
- More than 2 myocardial perfusion studies within the past 12 months
- More than 2 CT angiograms within the past 12 months
- Any subjects with history of radiation therapy.
- Patients already scheduled or being considered for a procedure or treatment requiring significant radiation exposure (e.g., radiation therapy, PCI, or catheter ablation of arrhythmia) within 12 months of randomization
- Pregnancy or breastfeeding
- Coronary artery luminal narrowing >70% seen on coronary CTA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00965185
|United States, Massachusetts
|Massachusetts General Hospital
|Boston, Massachusetts, United States, 02114
|Principal Investigator:
|Steven K. Grinspoon, MD
|Massachusetts General Hospital
Publications of Results:
Other Publications:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Steven K. Grinspoon, MD, Professor of Medicine, Harvard Medical School, Massachusetts General Hospital
|ClinicalTrials.gov Identifier:
|NCT00965185 History of Changes
|Other Study ID Numbers:
R01HL095123 ( U.S. NIH Grant/Contract )
|First Posted:
|August 25, 2009 Key Record Dates
|Results First Posted:
|February 26, 2015
|Last Update Posted:
|December 11, 2017
|Last Verified:
|November 2017
Cardiovascular Disease
treatment experienced
Cardiovascular Diseases
Pathologic Processes
Arterial Occlusive Diseases
Vascular Diseases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Enzyme Inhibitors


text:
Liberty News
Clayton King and rock bands get loud for Jesus at Winterfest
Liberty University's Winterfest is under way at the Vines Center. At this year's annual event thousands will ring in the New Year listening to Stellar Kart, Sanctus Real, Jeremy Camp and other Christian artists.
On day one of Winterfest, high school juniors and seniors were able to attend a meet-and-greet event in Liberty's DeMoss Learning Center. Christian punk band Hawk Nelson answered questions from the crowd and posed for a few pictures before heading off to warm up for the concert. John Cooper, lead vocalist for the band Skillet, also answered questions from fans at this event, and signed autographs.
"My parents would not let me listen to rock music for a long time, not even Christian rock music," Cooper told fans.
He hid his first rock CD, by Petra, from his parents. Eventually Cooper began playing rock music, and after another band he was in broke up, he formed the band Skillet at the encouragement of his pastor. He encouraged parents and youth pastors to work with teens because it can help teens to make positive life decisions.
"[People] Spending time with a younger person…and being willing to ask the hard questions- it's what changed my life the most," Copper said.
Later on, puppeteer and comedian Taylor Mason opened the concert at the Vines Center. Mason introduced a cast of five puppets to the Winterfest attendees — a pig named Paco, Sumo the wrestler, Romeo, Juliette, and Paquitto, the tiny pig. Mason revved up the crowd with this unusual cast and brought several volunteers on stage to try out the puppets for themselves.
After Mason's performance, Hawk Nelson and Skillet rocked the crowd, and speaker Clayton King made a loud and clear case for Jesus.
"[Jesus] came to give you something to be passionate about beyond the things that entertain you momentarily," King told the audience. "Jesus didn't come to take your life; he came to give you life."
Telling the crowd how important their own personal struggles are to Jesus, King cited John 10, where Jesus compares humanity to sheep and himself to a shepherd.
"You are not a neutral person in a neutral world," King said. "Satan is like a wolf; he's a thief who has come to kill…in a fight between a wolf and a sheep the wolf always wins."
"Jesus is protection from that wolf," he said. "Someone died so that you could live. You're that important."

subset: commoncrawl


text: PITTSBURGH (AP) - Brandon Sutter scored on a wrist shot from the left circle 8:18 into the third period, helping the Pittsburgh Penguins rally for a 4-3 victory over the Columbus Blue Jackets in Game 1 of the Eastern Conference quarterfinals on Wednesday night. Beau Bennett and Matt Niskanen scored power-play goals 45 seconds apart in the second period, erasing Pittsburgh's two-goal deficit. Jussi Jokinen also scored for the Penguins and Marc-Andre Fleury overcame some shaky defense to stop 31 shots. Game 2 is Saturday night. Jack Johnson, Mark Letestu and Derek Mackenzie scored for the Blue Jackets, who fell to 0-5 all-time in postseason games. Sergei Bobrovsky finished with 28 saves but was handcuffed by Sutter's knuckling wrister at the end of a 2-on-1 break. CANADIENS 5, LIGHTNING 4, OT TAMPA, Fla. (AP) - Dale Weise scored 18:08 into overtime to give the Canadiens the win at Tampa Bay in the opener of their first-round playoff series. Daniel Briere passed from behind the net to Weise in the right circle, and he beat Anders Lindback for the winning score. Lindback stopped 39 of 44 shots while filling in for injured goaltender Ben Bishop. Carey Price stopped 21 shots for the Canadiens, who blew a pair of third-period leads. Brian Gionta had a short-handed goal and Tomas Plekanec, Lars Eller and Thomas Vanek also scored for Montreal. Steven Stamkos scored twice for Tampa Bay, including the goal that forced overtime. Game 2 of the best-of-seven series is Friday night.


text:
Having a will is many things: It's a way to transfer assets, or to name a guardian for children who are minors. It's a way to ensure your wishes are carried out, and that the people you love are cared for after you're gone. It's a legal document that carries a great deal of emotion, so it can be difficult to start a will, let alone update it. But as your life changes, you should make sure you're updating your will along the way. What could trigger an update? How often should a will be changed? Here are a few scenarios:
Change in Marital Status
If you get married or divorced, you should update your will. If something should happen before you update your will, your spouse may not be the beneficiary, and could end up with less as a result. On the flip side, if you're divorced, your ex could end up with more than you intended.
Having Children
When children arrive, you're taking on a whole new level of responsibility. You should update your will to name a guardian for your children if you are no longer able to care for them. An updated will can also ensure that they're cared for financially should something happen to you.
Changes in Tax Laws
State and federal tax laws are always changing, so you'll want to be aware of any of these changes could impact your estate plan. Read up on any changes, and regularly consult your attorney to ensure that your will is not affected.
Preparing for the future? Try our Estate Planning Checklist!
Moving to a Different State
If your will was written in a different state, you'll want to consult an attorney in your new location to make sure your will is still valid. State laws can vary, and you don't want to assume that your will meets your new state's regulations.
Changes to Your Finances
If you inherit a large sum of money, you may choose to distribute your estate differently. You may also consider drafting a trust to help protect your estate from taxes, fees and mismanagement after you pass away.
On the other hand, if your financial situation takes a downturn, you'll want to re-evaluate your will. This can also impact how you choose to distribute your estate. In either case, you'll always want to talk to an attorney and/or an accountant for tax planning purposes.
Keeping Your Promises
A will is many things, but ultimately, it's a way to keep your promises. And if you want help protecting the things that matter most to you, talk to your local Farm Bureau agent. He or she can help you figure out a plan that works for you, no matter what your stage in life.
Neither the Company nor its agents give tax, accounting or legal advice. Consult your professional adviser in these areas.


text:
Our Purpose
DuPont is a science company. We work collaboratively to find sustainable, innovative, market-driven solutions to solve some of the world's biggest challenges, making lives better, safer, and healthier for people everywhere.
See how we are putting these words into action by making a difference in food, energy and protection.


text:
Former DC councilmember pleads guilty to bribery
Former District of Columbia Councilmember Michael Brown, the son of late Commerce Secretary Ron Brown, has pleaded guilty to bribery.
WASHINGTON (AP) — Former District of Columbia Councilmember Michael Brown has pleaded guilty in federal court to a bribery charge.
Brown, who was charged with bribery on Friday, entered the plea Monday afternoon.
Prosecutors accused Brown of accepting $55,000 in cash payments from undercover FBI agents posing as businessmen seeking preferential treatment from the city government.
He lost his bid for a second term in November. He ran again for an open at-large seat but abruptly dropped out in April, citing personal and family matters.
Brown is the third current or former member of the council to be criminally charged since January 2012.
The 48-year-old Brown is the son of Ron Brown, who was U.S. commerce secretary under President Bill Clinton. Ron Brown died in a 1996 plane crash in Croatia while leading a trade mission.


text:
"Embarrassment" Reviewed by Kansas City StarPosted Mar 14, 2011
The reviews keep coming in as "The Embarrassment of Riches: Picturing Global Wealth, 2000-2010" continues its run at the Nerman Museum of Contemporary Art. Check out the latest review by Alice Thorson, a reporter for the Kansas City Star.
Comments Off


text:
Published: 2005-11-02
Encryption experts met in Gaithersburg, Maryland, this week to discuss retiring the SHA-1 hashing algorithm and creating a stronger version of the cryptographic workhorse.
Over the past eighteen months, significant breaks of the Secure Hash Algorithm, SHA-1, have left confidence in the crypto algorithm essentially shattered. This week, a Who's Who of encryption experts met to discuss the problem and attempt to chart a course to a stronger hash function. While much of the proposed fixes build on old techniques, some new ideas did come our of the confab, according to a blog of the conference posted by well-known cryptographer Bruce Schneier.
Hash algorithms are mathematical techniques of producing digital fingerprints of files that perform a key function in encryption and digital signatures. A digital fingerprint, or hash, is a small string of numbers that represent a much larger file or document. A digital signature actually validates a document's fingerprint not the document itself, because signing an actual document would be far too processor-intensive.
The threat of a true break in the algorithm is not overwhelming. Cryptographers originally thought that a computer that could perform an attack calculation 1 million times every second would find a collision only once in 38 billion years. In February, the original break found by the researchers consisted of a method that could produce a collision once every 19 million years. A new technique found in August shortened that to once every 300,000 years. There's still some time left.
Posted by: Robert Lemos


text:
There's a lot going on in the CD/DVD printing world these days. In the last year we've seen new, rock bottom-priced thermal transfer printers, of all things; the emergence of 4800dpi as the standard resolution for inkjet systems; $100 all-in-one units like Epson's Stylus C200 that combine printing on all forms of paper with printing on CDs and DVDs; and the very recent announcement of new models based on HP's newest printer, including Microboards PrintFactory2.
Then there's the announcement that's sure to turn the most heads, especially in the videography space: Primera's (www.primera.com) long-awaitedBravoPro. A new CD/DVD publishing system designed to automate the production of up to 100 CDs or DVDs per job, the BravoPro may represent the best of all possible worlds for videographers with discs to produce. Obviously, none of us is just in the DVD printing business, or just in the DVD duplication business. We're in the DVD production business—or rather, it's DVD production, rather than mere duplication or printing, that's the key delivery step in our post-production process.
The BravoPro's claim to that territory is a strong one. Successor to the Editor's Choice award-winning Bravo, the BravoPro integrates a variety of components that have been lavishly praised in EventDV progenitor EMedia over the years: 52X PlexWriter CD recorders in the CD version and 16X Pioneer DVD±R/RW recorders with dual-layer support in the DVD version; Sonic's PrimoDVD premastering software; and Primera's own inline Signature Pro printer. New features include Primera's PTBurn network software, which allows up to five users to send CD and DVD recording and print jobs to a Bravo from networked client PCs. Additional licenses are available in five-user blocs for $299.95 each.
Of course, 100-disc automation is overkill for many event producers, and network disc production all but irrelevant. The Bravo's $3,995 list price for the DVD version may be well more than you're inclined to spend on DVD production equipment. If you primarily shoot weddings and other personal events, and your typical disc runs are a dozen or less, a standalone duplicator and standalone printer may well be more your speed, although you'll certainly pay a price in terms of time allocation without the automation a system like the BravoPro provides. And at less than $4,000 the BravoPro is much less expensive than many an automated DVD publishing solution. And if your business is—or even includes—shooting stage events, school productions, or local sports events where your disc output numbers in the dozens or even the hundreds, stepping up to an automated system with built-in print capabilities will pay quick dividends in the services you'll provide and the income you'll collect.


text:
Galleries of photos and pictures from the Vietnam War.
Hundreds of items including uniforms headgear, footwear, individual equipment, insignia
and weapons.
Chronology of the Indochina and Vietnam wars.
Brief bio's of key players and heroes of the war.
Battles and key events, military terms, acronyms, abbreviations and slang from the
Vietnam War.
Book reviews, war stories, features and news.


text:
The ICE Coalition represents a growing number of environmental, legal, business, academic and NGO stakeholders who advocate for an international rule of law that protects the global environment for present and future generations. We propose that an international court for the environment is necessary to address significant gaps in the current international environmental legal order.
International law can strengthen efforts to mitigate the continuing advance of climate change and environmental degradation, but not without a mechanism of enforcement for legally binding environmental agreements. Current international fora were not designed to resolve polycentric environmental disputes resulting from the complex management and mismanagement of modern transboundary collective action problems. Similarly, modern international environmental law has not been designed to be enforceable. The ICE Coalition proposes a radical and reasonable way forward.
It is our core position that a suitable mechanism must (1) be sufficiently specialized that the judiciary is able to weigh competing interpretations of complex scientific evidence against salient geopolitical, and international economic and social development priorities; and (2) offer standing to state as well as non-state actors in keeping with the principles of "access to justice" and erga omnes obligations owed not merely between states but to the international community.
This environmental dispute resolution mechanism, by itself, is an improvement on the existing legal order. However, a third, more demanding, objective for the effective enforcement of an international environmental rule of law is for modern international environmental law to be negotiated with the explicit understanding that it would be enforced by the compulsory jurisdiction of an ICE. If a presumption of weak enforcement has encouraged weakened obligations, then the availability of a strong mechanism of enforcement should give confidence to those willing to support stronger obligations.
We view our role as advocates for the creation of an international court for the environment, but more importantly as educators of how such a court could impact the development of an international environmental rule of law. We offer a number of ICE models to show how they would interact within the international legal order we have and the international legal order we want.
To generate debate and discussion, the ICE Coalition write articles and commentaries in popular journals and blogs, we organize and participate in public talks to share our coalition's accumulated knowledge on numerous subjects and we do the same when we work privately with representatives from government, academia, industry, international organizations, and the non-governmental community.
The purpose of this website is to answer some questions you may have about our work, where an ICE would fit in the international legal order, and to engage you in our advocacy.
Continue to the page footer below to navigate between the core sections of our site, COURTS (describes our models for an ICE, and our advocacy work), COMPARE (offers a compendium of international law resources), and CONTACT (encourages you to reach out to us and to join our coalition).
Welcome to our website!


text:
Global Medical Polymers Demand is Expected to Reach 6,411.7 kilo tons in 2018: Transparency Market Research
27 Aug, 2013, 10:30 BST
ALBANY, New York, August 27, 2013 /PRNewswire/ --
According to a new report published by Transparency Market Research "Medical Polymers, Resins and Fibers (PVC, PP, PE, PS), Elastomers (SBC, Rubber Latex), Biodegradable Plastics Market for Devices, Equipment, Packaging and Other Applications - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2012 - 2018," the global medical polymers demand was 4,391.0 kilo tons in 2011 and is expected to reach 6,411.7 kilo tons in 2018, growing at a CAGR of 5.6% from 2012 to 2018. In terms of revenue, the market was valued at USD 8.4 billion in 2011 and is grow at a CAGR of 8.4% from 2012 to 2018.
Browse the full report at http://www.transparencymarketresearch.com/medical-polymers-market.html
Increase in life expectancy leading to increased demand for healthcare treatment is expected to be the key driver for the medical polymers market. It is estimated that by 2050, over 16% of the global population would be over 65 years of age. This would result in higher demand for home healthcare treatment as the above-mentioned populations is the key segment for the market. Home healthcare directly impacts the sale of medical disposables, which are increasingly being made from polymers owing to reduced cost and superior performance. The development and use of biodegradable plastic in medical industry is also expected to be a key feature responsible for the development of the market over the forecast period.
Fibers and resins dominated the medical polymers market and accounted for over 85% of global consumption in 2011. PVC and PP were the highest consumed resins accounting for over 55% of the segment sale in 2011. However, engineering thermoplastics like PC and ABS are expected to have the fastest growth in the resins and fibers segment, growing at a CAGR of over 8% from 2012 to 2018. Medical Elastomers such as SBC, TPU, TPO, Silica Rubber and TPV among others were the second largest consumed product segment for the market and recorded consumption of over 550 kilo tons in 2011. In spite of its small market size, biodegradable plastics are expected to witness exponential growth over the forecast period.
Medical polymers are used in applications such as medical devices and equipment, packaging, cardiology stents and tissue engineering. Medical devices and equipment was the most dominant application segment for medical polymers in 2011 accounting for nearly 50% of the global volume. Medical packaging was the second largest application segment in 2011 and is expected to witness the fastest growth over the forecast period owing to substitution of conventional materials such as glass by PVC, PP and engineering thermoplastics.
North America was the largest consumer of medical polymers and consumed over 1,800 kilo tons in 2011. North America and Europe are expected to remain dominant markets for medical polymers over the next six years owing to the negligible impact of economic downturn on the medical industry in these regions. Asia Pacific is expected to be the fastest growing market over the forecast period majorly due to the shift in manufacturing activities from western countries to countries such as India and China.
Related & Recently Published Reports by Transparency Market Research
HVAC Equipment Market: http://www.transparencymarketresearch.com/hvac-equipment-market.html
Activated Carbon Market: http://www.transparencymarketresearch.com/activated-carbon-market.html
Pentaerythritol Market: http://www.transparencymarketresearch.com/pentaerythritol-market.html
Some of the key participants profiled in the report include DuPont, BASF, Bayer Material Sciences, Eastman Chemicals, Dow Chemicals, Kraton and Evonik among others. The report gives a comprehensive view of the medical polymer market in terms of volume and revenue. In addition, the report includes current demand analysis and forecast for each product in North America, Europe, Asia Pacific and Rest of the World. The report comprises of the following segments:
Medical Polymers Market: Product Segment Analysis
Medical Resins and Fibers
Medical Elastomers
Biodegradable Plastics
The product segments have been further analyzed based on the materials used in various medical applications.
Medical Resins and Fibers
Polyvinyl chloride (PVC)
Polypropylene (PP)
Polyethylene (PE)
Polystyrene (PS)
Others (Engineering thermoplastics such as ABS, PC, PET)
Medical Elastomers
Styrene Block Copolymer (SBC)
Rubber latex
Others (TPU, TPV, TPO)
Medical Polymers Market: Application Analysis
Medical Devices and Equipment
Medical Packaging
Others (Tissue engineering, cardio stents)
The report provides a cross-sectional analysis of all the above product segments with respect to the following regions:
North America
Asia Pacific
Rest of the World (RoW)
Browse all Chemical Industry Research Reports @ http://www.transparencymarketresearch.com/chemical-market-reports-2.html
About Us
Transparency Market Research is a global market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. We are privileged with highly experienced team of Analysts, Researchers, and Consultants, who use proprietary data sources and various tools and techniques to gather, and analyze information.
Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports.
Sheela AK
90 Sate Street, Suite 700
Albany, NY 12207
Tel: +1-518-618-1030
USA - Canada Toll Free: 866-552-3453
Email: email@example.com
Visit: http://www.transparencymarketresearch.com/
Visit: http://chemical-market-reports.blogspot.com/
SOURCE http://www.transparencymarketresearch.com/


text:
The Last American-made Running Shoe
New Balance is the last company that makes running shoes in the U.S., a testament to its commitment to domestic manufacturing. The economics are tough, but executives say they can also respond faster to custom orders. WSJ's Tim Aeppel reports.
This transcript has been automatically generated and may not be 100% accurate.
I ... yours are rare sight these days ... a US company that still manufacturing consumer goods in the US ... this is new balances factory in scout hated me ... the company the only one that still makes running shoes in America ... for one simple reason ... it's privately owned by former marathoner Jim Davis his wife Ann ... and they're willing to accept the costs about twenty five to thirty five percent more ... to make shoes in the U S and it does in Asia ... CEO Robert de martini says manufacturing is part of the company's DNA ... in the shale industry left the United States in the eighties and and and early nineties and we have always kept their five manufacturing facilities here in us ... to their manufacturing employment is higher than it's ever been ... and it's really been driven by learning how to make product of more effectively faster ... and higher quality level so we can compete ... in a category where its globally being priced based on offshore ... labor ... new balance is in the purest that makes about a quarter of issues it sells in the U S and its American plants the rest are important ... as the US look to providing its manufacturing sector ... many question whether labor intensive jobs like you making are worth saving at Mike's parents is man made you hear that argument from people that are theoretically talking about a macro economy ... if you're one of the twelve hundred people that have one of our jobs that with new fully loaded pays almost twenty dollars an hour ... you don't think that's an in significant job on all ... our ... factory employment has over ten years of ... experience which tells me that they like these jobs are some of the best jobs ... in the area and we are very low turnover which to me is the ... proof that somebody wants to do a ... deal him a candy is fourteen this work to new balances Cal Hakan plan for two-and-a-half years ... she stitched together pieces of shoes on a crowded production line ... making shoes isn't easy and some paths are specially tricky ... like that taps ... the very back and say that all ... the whole idea that together ... the very fact that the year he lay ... and that ... very small faking it for their very copied material ... have provided up to the margin in her bed all a laugh at the same ... really get caught out ... but all that he and working with the help of new machines is one reason the shoe industry is all the damage from the US ... today American ports ninety nine percent of its use mostly from Asia ... new balance as having U S factories means he'll do some things are competitors cannot but make custom designed shoes and deliver them to customers within five business days when ordered ... at the company's plant in or to our main just down the road going ... there's a line devoted to that ... Angela Greenwood says of all the different out she's done at the plant ... she likes making customized shoes that's ... in my ... life or death ... very heavy ... I ... they've consolidated ... I have a job ... in a one shot so if you're actually doing more ... of the different parts of the feel of a new way to end on a regular production line ... with ... I hear that the body and mind and content ... reporting from snowy Newark to walk me ... this is too tall for The Wall Street your ...


text:
AStudent writers from the Greenhill School, Hockaday, Booker T. Washington High School for the Performing and Visual Arts, Yavneh Academy, and Texans CAN Academy will read their works to open SMU's 2013 Literary Festival on Wednesday, March 20.
The Wordspace Student Readings, culminating in the 2013 Tale of One City Awards for outstanding high school writers, will begin at 6:30 p.m. in McCord Auditorium, 306 Dallas Hall.
The Department of English in SMU's Dedman College of Humanities and Sciences presents the annual celebration of writing and writers, which runs through Saturday, March 23. The four-day festival includes author readings, receptions, student conferences and book signings. All events are free and open to the public.
Since the early eighties, LitFest has featured writers such as John Updike, Joyce Carol Oates, Alice Walker, Norman Mailer, Robert Pinsky and Jill McCorkle. For 2013, the line-up includes:
- Camille Dungy is author of the poetry collections Smith Blue (winner of the 2010 Crab Orchard Open Book Prize), Suck on the Marrow and What to Eat, What to Drink, What to Leave for Poison.
- Vievee Francis has been published in Callaloo, Margie, Crab Orchard Review and Detroit's Metro Times. She is the author of Blue-Tail Fly, a Callaloo Workshop participant and Cave Canem Fellow.
- Alix Ohlin is the author of Inside, Signs and Wonders, The Missing Person and Babylon and Other Stories. Her work has appeared in Best American Short Stories, Best New American Voices, and on public radio's Selected Shorts.
- Matt Olzmann's poems have appeared or are forthcoming in Kenyon Review, New England Review, Salt Hill, Margie and other journals. He is a Kundiman Fellow and a writer-in-residence for the InsideOut Literary Arts Project.
- Alan Michael Parker has received awards and fellowships including three Pushcart Prizes, the Fineline Prize from the Mid-American Review, and the Lucille Medwick Memorial Award from the Poetry Society of America. His novel, Whale Man, was a finalist for the 2011 ForeWord Reviews's "Book of the Year Award" in the category of Literary Fiction.
- Natalie Serber, recipient of the John Steinbeck Award, Tobias Wolff Award, and H.E. Francis Award, has been short-listed in Best American Short Stories. Her latest book is Shout Her Lovely Name, a collection of stories about the relationships between mothers and daughters.
- Tatjana Soli's first and second novels, The Lotus Eaters and The Forgetting Tree, have won awards including the James Tait Black Memorial Prize, New York Times Notable Book 2010, ALA 2011 Notable Book, LA Times Book Award Finalist, Kirkus Reviews Top Debut Fiction, and Bookmarks Magazine Best Literary Fiction.
- Debra Spark, author of the novels Coconuts for the Saint, The Ghost of Bridgetown and Good for the Jews, edited the best-selling anthology Twenty Under Thirty: Best Stories by America's New Young Writers. Her newest book is The Pretty Girl, a collection of stories about art and deception.
For more information and the schedule of events, visit the official SMU LitFest blog at smu.edu/litfest.


text:
Mplus Home
Last Day
Last 3 Days
Last Week
Tree View
Edit Profile
Individual varying times of observation
Mplus Discussion
Growth Modeling of Longitudinal Data
Daniel Rodriguez
posted on Wednesday, March 13, 2013 - 10:33 am
Hello, I ran a growth curve model with individually varying times of observation and am wondering how to interpret the results in terms of units of time. My time variable is hours from birth and my dependent variable is attention/orientation. Since I am not setting any specific time unit, could I say that hours from birth is my unit such that an hour increase in birth results in a beta change in attention?
Linda K. Muthen
posted on Wednesday, March 13, 2013 - 6:00 pm
Yaoyue Hu
posted on Thursday, December 12, 2013 - 11:59 am
I am running a growth curve model of 4 time-point data with individually varying time of observation. In this case, chi-square cannot be calculated as the covariance matrices could be held constant across individuals.
However, given loglikelohood, AIC and BIC, how could I tell which model fits the data better, the linear growth curve model or the non-linear model (add a quadratic growth factor)?
Many thanks!
Linda K. Muthen
posted on Friday, December 13, 2013 - 10:22 am
See if the quadratic mean is significant. If so, go with the quadratic model.
Yaoyue Hu
posted on Sunday, December 15, 2013 - 2:43 am
Dear Linda
Thank you very much for your reply.
Given my data, I have more questions about the way to fit the growth curve model:
1. I have a four time-point data of cognitive function from participants aged 45-70 at the first measurement occasion, as well as individually varying time of follow-up.
As suggested by Mehta & West (2000), I am planing to carry out my analysis centering the age at 59��mean age at baseline��at every measurement occasion. Therefore, the interept factor is the mean cognitive function at 59 years old and the slope factor is the rate of change in cognitive funtion per year.
Does the age in my data have a too wide span, which might not be suitable to use the centering age at a specific age technique?
2.When I fitted an unconditional non-linear growth curve model, the linear slope is not significant but the quadratic slope is. Further adding covariates into the non-linear model, neither linear slope nor quadratic slope is significant any more.
Should I choose the model, the linear or non-linear, based on unconditional model or conditional one?
Again, many thanks for your help!
Bengt O. Muthen
posted on Sunday, December 15, 2013 - 11:01 am
1. That centering should be fine. The wide age range has more impact on the growth function - whether it can be said to be linear or e.g. quadratic.
2. When you add covariates, your output shows the intercepts, not the means, of the growth factors. The means are seen in TECH4.
Back to top
Add Your Message Here
Posting Information:
This is a private posting area. Only registered users and moderators may post messages here.
Enable HTML code in message
Automatically activate URLs in message
Tree View
Program Credits


text:
Friday 6 and 8:15 pm; Saturday 4:45 pm; Sunday 12:00, 2:15 and 4:30 pm
Testament of Youth is a powerful story of love, war and remembrance, based on the First World War memoir by Vera Brittain. A searing journey from youthful hopes and dreams to the edge of despair and back again, it's a film about young love, the futility of war and how to make sense of the darkest times.
129 minutes; Rated PG-13
Magnolia at the Modern is an ongoing series featuring critically acclaimed films. Tickets are $9; $7 for Modern members; $6 for Reel People. The Sunday noon show time is half price. Advance sales begin two hours prior to each show.


text:
Art Print | Pacific Northwest: Mt St-Helens 9356
Art Print | Pacific Northwest: Mt St-Helens 9356
Part of the Pacific Northwest Collection (Mt St-Helens, Washington)
GALLERY FINE ART prints
Gallery quality Giclée print on bright-white, 100% cotton rag for archivability, museum quality, acid-free base, 260 g/m2.
Featuring a velvet surface for a distinctive museum-quality feel.
Ideal for the texture lovers.
MATTE SMOOTH prints
Archival, enhanced matte acid-free paper. Ideal for anyone looking for a flat matte surface.
A statement in any room.
See below more sizes, available upon request:
These Fine Art Prints are printed in a lab here in Northern California on a Velvet Watercolor paper /// 310 gsm, No OBA's, Bright White, Acid Free
13x19 inches $105
14x22 inches $110
16x20 inches $115
16x24 inches $120
18x24 inches $125
20x30 inches $170
30x40 inches $275
40x60 inches $490


text:
Y-3 Logo Scarf
- Description
- Details
The versatile Y-3 Logo Scarf elevates your winter look with its simple yet sophisticated design. A cosy statement piece, the soft scarf is made from a premium knit blend of Merino wool and nylon.
Y-3 logo graphic badge on end; Dimensions: 190 cm x 27 cm; 70% Merino wool / 30% nylon knit


text: Free Hugli and Chinsurah West Bengal Business Directory in India to Find Local Hugli and Chinsurah West Bengal Listings We have found 0 business listings matching your search query. There were no results found for your search query. We did not find any results for your search query. Please try again with a different search query.


text:
Take a look at some of Monday's midday movers:
Apple jumped after Barron's said the stock is on its way to hitting $800 a share. The stock is down about 20 percent off its $705 intraday high hit 2 months ago.
Banks among the leaders today on optimism Washington will come up with a budget deal. Bank of America, Citigroup, Suntrust, JPMorgan, and KeyCorp all moved higher.


text:
A long battle is over for me and I'm not talking about one of my violent hardcore matches!
Recently, I got a phone call that I have been waiting for some time. A gentleman from the Ontario Human Rights Commission (OHRC) told me that I had finally won what is perhaps the most important fight of my career as a professional wrestler.
With that, it's time for a history lesson.
It was the weekend of Wrestlemania 22 and yours truly was scheduled to participate in a match for a promotion right in Toronto. The match would be a hardcore, inter-gender tag team bout and it was pretty exciting time for me back then. I was really getting a lot of bookings in Ontario and fans were really receptive to what I was doing in the ring.
But it all came to a crashing halt.
I got an e-mail from the promoter, telling me that he couldn't book me anymore. Why you may ask? Turns out, some rival promoter in Toronto decided to file a complaint with the Ontario Athletic Commission (OAC). You see, in the province of Ontario, professional wrestling is actually regulated by the OAC, which is a branch of the Ministry of Consumer Affairs.
I didn't know it at the time, but there was a clause in the act that oversees professional wrestling, stating that a man and woman may not come into contact in the ring. Yep, that's right - in the year 2002 such a rule still existed on the books.
The commissioner, having no choice but to enforce the regulation as a result of the complaint, proceeded to contact the promoter and advise that that match I was scheduled to participate in could not happen.
To say I was slightly pissed off at that time would be an understatement. I was really upset. The simple fact that there was a regulation that basically said I couldn't do what I love to do because I'm a girl really got me down. I know some people out there don't like the idea of girls wrestling guys in the ring and I do respect those views. But this regulation was simply wrong!
What could a girl do?
The fact is, lots of people in the wrestling business (in Ontario) love to complain about the OAC. Granted, I have my own opinion about whether wrestling should be regulated or not, but the fact is, the regulation in question was there and bitching about it on message boards was not going to get that rule off the books.
After consulting with some close friends of mine, I proceeded to file a complaint with the OHRC. This was the only route I could take if I wanted to fight the government.
From the first moment I spoke with a representative at the OHRC, I received nothing but unconditional support for my cause. They saw what I saw, that the regulation in question was a violation of my human rights, based on my gender. I filled out the necessary paperwork and it was time to take down that regulation.
I realized early on that this would not happen quickly. Change comes slowly in government and I had to be patient. Fortunately, I had lots of support from my fellow workers, promoters and friends in general. They really helped keep my spirit up when I thought that I would never see the light at the end of the tunnel as it were.
For a while, it seemed like there was going to be a showdown with the OAC in Toronto in the form of a hearing, but it never happened. I can only guess why; maybe the OAC realized they didn't have a chance when it came to defending such a regulation.
From there, I stayed in contact with the OHRC as they pursued the complaint for me. In the end, it came down to just one phone call. I was told that the OAC would proceed with removing the regulation once and for all.
The fight was over and I won!
Words can't describe how great it feels. To be blunt, this was my fight and I was very passionate about doing it my way. I did my homework, plotted a battle strategy and executed the plan. Mission accomplished!
For the record, I want to make it abundantly clear that in no way do I harbor any ill feelings towards the OAC or the commissioner, Ken Hayashi. I realize that back then, he was just doing his job, which is to enforce the rules and action complaints that his office receives.
For now, I'm just waiting to see when the rule will be officially removed for good. I must say, there is a part of me that is glad I went through this. I learned a lot about myself and what I can achieve when I put my mind to something that I feel passionate about.
For those of you out there who may think you can't win against the government, think again. It's not easy and it will take time, even some of your own hard-earned money. But if you truly believe in your cause, then charge forth and fight the good fight.
To all who supported me, you will always have a special place in my heart. To all who said I couldn't win, I thank you as well. You only gave me that much more motivation to keep fighting.
And yes, to the coward that called the OAC and filed the complaint against me, I want to thank you as well. You started this saga and I'm the one who finished it. It's me who's standing the ring of life with her arm held in the air as the winner and that's something you'll never be.
SLAM! Wrestling thanks LuFisto for permission to reprint this column, which was originally published on her website. For more back ground on LuFisto's battled with the OAC, please read Mike Altamura's article from 2003 entitled Inter-gender turmoil in Ontario.


text:
Full Traction Suspension - Smoothing Out The RidePosted in How To on January 1, 2011
There has really never been a love/hate relationship at OFF-ROAD magazine like the one between the staff and our Super Duty, the STD (the Super Turd Diesel).
It's a first generation 6.0L truck that has seen enough problems to be lemon-lawed, but we look at every one of those problems as opportunities to learn more and get some cool articles. Of course, we've had to basically replace or rebuild almost every component on this truck, but we're really starting to get somewhere.
If you've been a loyal reader over the better part of the last decade, you might remember how many tires, wheels, seats, tuners, gears, turbochargers, driveshafts, bumpers, and suspensions have been on this truck. In all that time, there have been a few things pulled off this truck that we would like to have seen stay on. One in particular happened to be the Full Traction coilover conversion and King shocks that were put on this truck back in 2006. The kit was ideal for the way this truck is used, and after many years and many kits, we've (again) gotten a Full Traction kit to outfit our Super Duty and get it closer to our goal of a finished and superior Super Duty that would make any 2010 truck owner jealous.
Driving on the New Suspension
The day after we finished the suspension, we took off on a long cross-country trip, giving us the ability to really live with this suspension for a couple weeks.
We've tried numerous suspensions on this particular truck, and none have performed like this Full Traction and King coilover package. The on-road ride was excellent, and the improved off-road bump damping was incredible. If we were looking for more extreme twist for a hardcore trail rig Super Duty, we think we'd use a lighter-rate sway bar, but for all-around use and high-speed driving, this sway bar works excellently.


text: In Tokyo today, newspapers printed extra editions to report about the women soccer team's victory in the World Cup. Yoshikazu Tsuno /AFP/Getty Images hide caption toggle caption Yoshikazu Tsuno /AFP/Getty Images Opinion The Two-Way For Devastated Japanese, World Cup Was 'More Than A Game' July 18, 2011 There's no shortage of reports about how important the victory in women's soccer was across the Pacific in a nation still recovering from the devastating March 11 earthquake and tsunami. Does losing to Japan ease the pain for U.S. fans?


text:
Bienvenue and welcome to Lausanne, one of the largest and most charming cities in Switzerland's French-speaking western region. As the largest platform for expatriates around the world, InterNations is here to make your relocation to this picturesque European city as easy and hassle-free as possible. Many travelers have used the resources available on our platform to find advice, information, and the answers to frequently asked questions on subjects such as salary expectations for jobs in the region, public transportation links to Geneva, and where to find the best local markets. Our members are always happy to offer tips and recommendations, and you may even make a few new friends along the way. Don't forget to share your own experiences online in our forums or in person at our events after you've had some time to settle in. A small but dynamic city with a lot of character and the stunning scenery of Lake Geneva and the Jura Mountains right on your doorstep, there's always something new to experience when you choose to spend time in Lausanne, from a stroll through the open air markets to a glass of wine or a pint of craft beer in one of the city's busy bars and restaurants.
With InterNations, you never stand alone. Whether you move to another city or go on a business trip somewhere — our communities are there to make you feel at home wherever you are in the world. Feel free to also check out our other vibrant InterNations Communities like the ones in Shanghai or Jeddah.
Attend our monthly events and activities for Lausanne expatriates to get to know like-minded expatriates in real life.
Get trustworthy advice and local insights from fellow members in our Lausanne expat forums.
With two highly regarded universities, the International Olympic Committee, an acclaimed design school, and numerous art galleries and museums, the Swiss city of Lausanne certainly packs a lot of culture into a relatively small space. With beautiful lakeside views and a host of carefully tended parks and gardens, it's also a city that more than lives up to Switzerland's reputation as one of Europe's most picturesque locations. Unsurprisingly, tourism plays a major part in Lausanne's economy, although key industries such as financial services and communications also attract many business-minded expats, as does the close proximity to Geneva. The primary language of the region is French, and although English is widely understood it may be helpful to learn the local tongue, particularly if you're expecting a long-term stay in the city. The large student population inevitably influences the cultural life of the city, with a more active nightlife than you might expect for a mid-sized Swiss city, in addition to a thriving arts scene, making life in Lausanne a multifaceted expat experience that you can really make your own.
InterNations is the largest global network for expatriates, with communities in 420 cities across the globe. Get to know fellow internationals in your city, before you're moving, or when traveling somewhere and never feel like a stranger. InterNations makes it easy for you to stay in touch with your expat friends, both online and offline, so you can grow your network of friends and contacts from all over the world. Whether they live in Hong Kong or Singapore, InterNations allows you to be close to them even if they are miles away.
At InterNations we provide a safe, secure, and welcoming environment where expats in all corners of the world can share advice, recommendations, and insights about the many obstacles, challenges and opportunities of living abroad. Our members are dedicated to upholding our core principles of respect, open communication, and honesty in all of their interactions, both online and offline, meaning you can feel free to share your questions and concerns about life in Lausanne in a friendly and supportive environment. You might be looking for a tip on a rental opportunity in the area, legal advice from a trusted and qualified local professional, or recommendations for a language course, or you may simply wish to find like-minded fellow travelers to form a sports group, attend a wine tasting evening or sample the local nightlife. Whatever you're looking for, our members will be happy to help. You can also take advantage of the regular networking events hosted by InterNations in the city, allowing you to mix with fellow expats over friendly drinks, delicious food, and fabulous entertainment in one of Lausanne's top venues.


text:
Free shipping over $ 99
Free shipping over $ 99
"Momento" by Aldo Rossi is an object for the person. It was the first watch in the history of Alessi, and a new version is now being introduced. The watch is composed of a simple double steel case.
Born in Milan (1931-1997), he is considered by many to be the greatest Italian architect of the second half of the 20th century. His life as an architect started with Gardella and Zanuso. An author of abstraction, reduction and brevitas, his severe language of primary shapes, geometrical patterns and silent evocation created some of the most intensely poetic works of architecture and design in his age.


text:
The Mailexpress Trains are series of express passenger trains services in India operated by Indian Railways connecting New Delhi with mostly capital cities of other states.
Mailexpress Trains are popular for his speed, few stops and the maximum priority on the Indian railway IRCTC network. Mailexpress Trains are fully air-conditioned and has only three classes accommodation for the passengers AC First Class with 2-berth and 4-berth lockable bedrooms, AC 2-tier with open berths with curtains for privacy, AC 3-tier with bays of 6 berths + 2 berths on the side) without curtains. Currently there are Mailexpress Express Trains, connecting New Delhi to important cities across the country.
Alltraintimes.com offers Mailexpress trains time table schedule with the details source and destination, arrival and departure time, Mailexpress train no. and name, route map, specific routes, train zone and much more on single place.
|S No.
Please note all the information shared on this site are intended for general usage. We hereby confirm that www.alltraintimes.com is a private portal and claim no direct connection with Government of India Railway sites or Indian railways official sites in any ways. Content available in this website is for information only; all the information available are personal in nature and for non-commercial use only.
Minor discrepancy may occur in case of data fetched from the sources are not updated; please note All Train Times holds no responsibility of such discrepancies. Read more...
This platform fetches data from various sources to come up with information regarding PNR Status, various Train Routes, availability of trains, train Running Status, Departure and Arrival of Trains at various Stations, Fare Chart and are subjected to change without any prior notification. We intend to provide the best and most accurate data however, passenger enquiries should always be re-verified at the official sites (www.irctc.co.in) before processing any request or making a plan.


text:
The Legal 500 Hall of Fame highlights individuals who have received constant praise by their clients for continued excellence. The Hall of Fame highlights, to clients, the law firm partners who are at the pinnacle of the profession. In Europe, Middle East and Africa, the criteria for entry is to have been recognised by The Legal 500 as one of the elite leading lawyers for seven consecutive years. These partners are highlighted below and throughout the editorial.
Click here for more details
Netherlands > Legal Developments > Law firm and leading lawyer rankings
Search News and Articles
The employment of foreign workers. What issues do you need to be aware of as an employer?
The employment of foreign workers regularly raises questions. A brief summary of the most important areas of attention will be dealt with in this article.
Work permit
The main rule, based on the Foreign Nationals Employment Act (Wet Arbeid Vreemdelingen, hereinafter called 'Wav'), is that it is prohibited for an employer to allow 'a foreign national' to carry out work if they do not have a work permit. A work permit is not required for a citizen of a member state of the European Union (EU). A work permit is also not required for a citizen of a member state of the European Economic Area (EEA). For workers from member states who joined the EU on 1 January 2007, namely Bulgaria and Romania, however, a work permit is still required.
Definition of the term "employer"
The definition of the term "employer" in the Wav is rather broad, and is different to the way the term "employer" is defined in other legislation. If work is carried out at the direction of, or in service of, a party, this party is considered to be an employer under the Wav. A consequence of this broad definition under the Wav is that a foreign national can have several employers. Each of these employers must check to make sure a work permit has been obtained for the foreign national. If a work permit has not been obtained for a foreign national, a fine can be imposed on all of the employers of the same foreign national.
Granting of a work permit
In principle, a work permit will be granted by the UWV WERKbedrijf (employment services agency) if no suitable personnel can be found in the EU or the EEA for the relevant position to be filled by the foreign national. The employer must notify the vacancy to the employment services agency at least five weeks before the application for the work permit is made.
No work permit required.
There are several exceptions to the prohibition on the employment of foreign nationals without a work permit.
Self-employed persons
No work permit is required for persons who carry out work on a self-employed basis.
Multinational corporations
A work permit is not required for employees of multinational corporations in certain cases. These multinational corporations must have an annual turnover of at least € 50 million. Furthermore, the employee of the multinational corporation must be part of the management or highly qualified, and have an annual income of at least € 50,000. Furthermore, employees of a multinational corporation may work on outplacement for a maximum of one year in connection with the exchange of specific knowledge or technology. In such cases, the relevant employees must be qualified to at least higher vocational (HBO) level.
Incidental employment
In addition, a work permit is not required if a foreign national carries out incidental work during a very short period, for example in order to hold business meetings, sign contracts (maximum of four weeks), the installation or modification of software (maximum of 12 weeks), or for the performance of artistic works.
Knowledge migrants
Finally, no work permit is required if a foreign national can be designated as a knowledge migrant. A knowledge migrant is a foreign employee who is employed by a Dutch employer, or who is transferred to a Dutch branch of his or her foreign employer, and whose gross annual income is at least € 50,619. If the employee is aged under 30, he/she must (currently) have an annual income of at least € 37,121. For foreign students who have completed academic studies in the Netherlands, and who find a job as a knowledge migrant within one year, the minimum income threshold is currently € 26,605. The above amounts are adjusted annually. Moreover, knowledge migrants, regardless of their salary, are also deemed to be: foreign doctors training to become a specialist in the Netherlands, scientific researchers, and non-European students who are studying at a Dutch educational institution and who want to follow an internship in the Netherlands. An employer must, however, sign a covenant with the Immigration and Naturalisation Service (IND) before they can make use of the exemption under the knowledge migrant regulations.
Financial penalties
The inspectors of the Health and Safety Inspectorate carry out checks to make sure an employer has a valid work permit for each foreign national. If an employer has failed to apply for a work permit for a foreign national, an administrative fine can be imposed on the employer. This fine can be up to a maximum of € 8,000 per foreign national. In addition, fines can be imposed on the employer in relation to administrative failures. As pointed out earlier, a fine can be imposed simultaneously on several employers of the same employee, for example the employment agency hiring out the employee and the host company. In practice, the host company will often try to recover the fine from the employment agency. However, recovery of this fine is only possible if agreements have explicitly been made about such between the host company and the employment agency.
In conclusion
The above gives a brief summary of the regulations in relation to work permits for foreign nationals. If you would like to know more about the regulations described above, you can get in touch with the editorial board of the newsletter.
For more information please visit www.akd.nl


text:
• arrogate •
æ-rê-gayt • Hear it!
Part of Speech: Verb, transitive
Meaning: 1. To lay claim to something to which you have no right; to appropriate inappropriately. 2. To claim something to which you have no right or legitimate claim for someone else.
Notes: We often use the adjective arrogant without thinking of its origins. It is easy, however, to see how arrogating is a form of arrogance, for you can arrogate importance as well as the property of others. Because arrogance has shifted its meaning, today's verb has created another adjective for itself, arrogative, as someone with arrogative tendencies. The noun is arrogation.
In Play: In its most direct sense, today's word refers to the action of laying claim to anything that isn't yours: "Ford Parker seems to have simply arrogated his father's car after driving it for two years." This word is always convenient around aggressive people who like to take control: "When did you arrogate the power and wisdom to organize our trip to the beach?"
Word History: Today's Good Word is built on the past participle, arrogatus, of the Latin verb arrogare "to arrogate", itself made up of ad "to + rogare "to ask". The ultimate source of the root in rogare, rog-, is the Proto-Indo-European root rog-/reg- "move in a straight line" with the Shifty O that is sometimes E. The O-form appears in many Latin words we borrowed: abrogate, interrogate, and prerogative. English directly inherited the root as rake. The E-form turns up in words referring to measuring sticks, such as ruler, which goes back to Latin regula "a straight stick". The other type of ruler should also be straight, so the word for "king" was also associated with this root; it turns up in Hindi raja and Latin rex (reg-s). The Latin word became roi "king" in French, the adjective of which, royal, we also pilfered. In English the E-form, reg-, turned out to be rich. Quite a derivational trip, don't you think?
P.S. - Register for the Daily Good Word E-Mail! - You can get our daily Good Word sent directly to you via e-mail in either HTML or Text format. Go to our Registration Page to sign up today!
Come visit our website at <http://www.alphadictionary.com> for more Good Words and other language resources!


text:
Chemistry track
Understanding how our systems work, in order to improve and extend.
Explore how our technology works on the lowest levels, and what that can teach us about optimal use. Tell us your analysis and profiling techniques, how implementation affects function, and what a kernel is made of.
Sessions for this track
* A Database Called The Web
In 2002 people wanted to build a database to track creative works; we built that database and it's called the Web.
|Nathan Yergler
* An Introduction to Computer Vision
Learn about several computer vision techniques and how to put them together to form an entry-level object classifier.
|Matthew Dockrey
* Android location services from social networks to games
Adding real-world location to mobile applications on the Android platform takes users out of the ethernet and into the world.
|Don Park
* Domo Arigato Mr. Roboto
This session is for developers who want to learn about the Android platform. Android is a software stack for mobile devices that includes an operating system, middleware and key applications. We'll discuss the Android toolset and platform API's.
|Sean Sullivan
* Drizzle, Rethinking MySQL for the Web
Rethinking MySQL for the modern web.
|Brian Aker
* Drop ACID and think about data
Survey of current database technologies beyond the traditional ACID RDBMS
|Bob Ippolito
* Is the Web Down: a Practical Tutorial on How the Web Works
You click on a link and you can't get to your favorite web site. Now what? Is the web site down? Is it your connection? Is it something in between? How can you figure out what's wrong if you don't know how it works? We'll show you everything that happens after you click a link so next time the web site is down you'll know what to do to fix it.
|Michael Schwern, Joshua Keroes
* Layers of Caching: Key to scaling your website
Caching is essential to ensuring that your website will survive a large spike in traffic. With so many different forms of caching, how are you supposed to know what works and why you should use it? The key is layering your site with several forms of caching.
|Lance Albertson, Narayan Newton
* Open Source Microblogging with Laconica
Microblogging lets people share short status messages with their social network. Public Web sites like Twitter, Jaiku and Plurk are wildly popular with consumers, but Open Source programs allow a distributed social graph and implementation inside the enterprise firewall. Evan Prodromou, founder of Identi.ca, will describe the Open Source microblogging tool Laconica and its uses in the workplace and on the Public Web.
|Evan Prodromou
* PHP - Architecting and Profiling for performance
A look at efficient PHP development through proper architecture and profiling tools.
|Rasmus Lerdorf
* Speed up that library when you can't C a thing
The problem: you're using a modern dynamic language not known for speed, and you've identified a bottleneck. Write it in C? Does that give you the shakes? There are other language options available...
|John Melesky
* The Linux Kernel Development model
How the Linux kernel development model works.
|Greg Kroah-Hartman
* Virtualize vs Containerize: Fight!
Everyone has a different reason to love virtualization: security, configuration isolation... the list goes on. But containerization offers many of the same goodies as virtualization, alongside an efficiency and performance advantage. Just what you need, more options. There's no wrong answer. Andy de la Lucha and Irving Popovetsky help you ask the right questions about what's right for your environment.
|Andy de la Lucha, Irving Popovetsky
* Web Server Shootout
Deploying your .com behind nginx so you're ready to handle that flood of users on launch day? Wondering if you should use mod_python, mod_wsgi, or FastCGI to deploy your new Django project? This presentation will present comprehensive and practical benchmarks across a wide variety of metrics to help you make an informed decision.
|Michael Schurter
Proposals for this track
* 3rd generation Linux Networking
Linux has best of breed networking, but has a long way to go in usability.
|2009-02-27 00:26:14 +0000
|Stephen Hemminger
* Can I get a date please?
|2009-03-29 11:51:01 +0000
|Philip Tellis
* Data Visualization With GGobi -- A Hands-On Tutorial
GGobi is an award-winning open source data analysis and visualization tool. This hands-on tutorial will focus on visual methods for classification, also known as supervised machine learning. Install packages and sample data tested on Ubuntu, openSUSE and Fedora will be provided.
|2009-03-30 23:05:27 +0000
|Ed Borasky
* Digital Noises
Computers make noises, record noises, and change noises with a fluency and grace that has never before been seen in the world. Open source is perfectly placed to take advantage of this capability --- for those who understand how digital audio works.
|2009-04-10 07:01:53 +0000
|Bart Massey
* FreeTUIT - Codeless GUI Programming
FreeTUIT is desktop programming with less code. A concise, declarative syntax for widget layout and an expressive API for runtime give you clean and maintainable wxWidgets cross-platform applications in minutes.
|2009-03-30 05:51:06 +0000
|Eric Wilhelm
* Geocoding from TIGER
Want to geocode address information, but don't want to depend on outside services, or expensive commerical products? In 2007, the US Census released its updated TIGER data, providing the best free source for US street data. I'll demonstrate the new version of tiger_geocoder, and talk about ideas for future development.
|2009-03-31 20:22:22 +0000
|Darrell Fuhriman
* How to Get a Chump Like Me to Start Using Your Open-Source Framework
"Frameworks. We can't live with 'em, we can't live without 'em."
|2009-04-02 16:42:22 +0000
|Jeffrey McManus
* I'm "ok", you're "not ok": The Test Anything Protocol
TAP(Test Anything Protocol) is a simple way to write tests in any language, in any environment, using any style. See tests written in Perl, Ruby, Python, Shell, Javascript, C, PHP and Postgres all come together in one test suite. Learn how to write your own testing functions, tailored to your needs. Archive your test results and watch your test suite grow!
|2009-03-24 05:43:29 +0000
|Michael Schwern
* Keep your fork(), there's pie
an introduction to the OAuth protocol and OAuth libraries
|2009-04-11 06:19:53 +0000
|Sean Sullivan
* Managing Infrastructure as a Development Project
If your IT organization has a team of system administrators that only fight fires and deliver the same things time and time again, it could be time to adjust their thinking and methodologies. This presentation will explain how borrowing concepts from Computer Science and Software Engineering can help create a high performing administration team.
|2009-04-06 15:07:42 +0000
|Michael Stahnke
* Open Source CAD/Graphics Backstage Tour
An overview of open 2D/3D CAD and graphics programs and toolkits from the programmer's point of view. Learn what tools are available for building solutions to graphics and modeling problems and how they work.
|2009-03-30 18:24:58 +0000
|Eric Wilhelm
* Open Source Tools In Computational Finance
Computational finance is a topic on many peoples' minds in the current economic climate. Over the years, an impressive body of open source software has been developed in computational finance. In this talk, I'll review the major open source CF tools and demonstrate an application of them to some financial time series taken from recent market activity.
|2009-04-05 19:12:23 +0000
|Ed Borasky
* Opinionated Frameworks for Opinionated Developers
Do opinionated frameworks make it easier or harder to write great opinionated software?
|2009-04-01 14:05:10 +0000
|Wil Sinclair
* Perl is Undead
Everyone knows Perl is dead and Perl 6, that long-delayed second system design by committee mistake, will never be released, and all Perl code is unreadable, executable line noise... right? Real-live modern Perl programmers will prove that wrong.
|2009-04-11 01:44:27 +0000
|Michael Schwern, Chromatic X
* Plone in the Cloud - deploying open source applications to Amazon EC2
The rise of utility computing platforms such as Amazon EC2 has made it more feasible to build turnkey hosted solutions on top of open source software. Learn how we built PondCMS, a turnkey Plone-based CMS deployed to Amazon's EC2. In this talk, we will discuss the advantages of hosting Plone sites in the elastic computing cloud and some of the challenges we faced.
|2009-04-11 00:38:39 +0000
|Nate Aune
* Rubinius 1.0: The Ruby VM That Could
This talk will give an overview of Rubinius, an alternative Ruby implementation with a C++ VM, Ruby standard library, and Ruby compiler. It will also detail major recent changes like switching away from stackless execution and improvements in the core library data structures, garbage collector, compiler, and JIT assembler.
|2009-02-16 18:18:37 +0000
|Brian Ford
* testing email send
testing email send
|2016-04-23 22:31:36 +0000
* Tracking Package Freshness
Come find out which distribution is best... at keeping their official repositories up to date. Or which distribution has the most up to date LAMP packages. This presentation explores trends culled from package releases since October '08, discusses the challenge of making sense of it all and possible improvements to distribution and package maintenance.
|2009-03-26 03:41:50 +0000
|Scott Shawcroft
* Troubleshooting Linux I/O Performance With Open Source Tools
While the Linux I/O architecture is complex, a number of open source tools exist that make finding bottlenecks easier. These tools include traditional Unix utilities like "iostat", but they also include some tools that go deep into the block layer and give you information about major events in the life of every I/O operation.
|2009-01-27 01:10:25 +0000
|Ed Borasky
* TwitterClipse - Hacking Eclipse for Fun and Profit
By adding Twitter support to Eclipse, we explain how Eclipse works, what Bundles are and how to write your own.
|2009-04-09 23:40:48 +0000
|Elias Volanakis, Scott Lewis