text:
Tuesday, August 17, 2010
Some hippies deserve to be punched.
Two months ago I went to a friend's dinner party. For an uncultured, masturbation machine like myself it was good to mingle amongst people with such varying political opinions, while hypertension inducing delicacies and liver enlarging spirits served as the backdrop. I have to say, as much as I usually take the scorched earth, bring a motherfucking missile launcher to a knife-fight approach to debating republicans - the right leaning guests at my friend's dinner party came equipped with an arsenal of substantive arguments. No birtherism. No 14th Amendment talk. I don't even think the word "socialism" was uttered once. Usually, as a republican is making his/her arguments, I'm openly wondering whether or not slashing my wrists and bleeding out all over the place in an act of utter disgust is theatrical overkill. But that night, refreshingly, I fully embraced those fleeting moments of political civility that are few and far between these days. What really threw me for a loop that night was the heated back and forth that I got into with someone I believed to be my liberal, dope smoking brethren - my friend's older brother, a hippie named Miles. It wasn't as if some of his arguments weren't substantive mind you, the snails pace it is taking to close GITMO and end DADT are legitimate criticisms, it was the unwarranted vitriol towards Obama that they were laced with that gave me such pause. At first the rhetorical sparing we did that night felt like Déjà vu, any honest person with a computer will admit that segments of the liberal blogisphere are littered with garden variety defenses of Obama being carelessly characterized as lockstep sycophancy and accusations that the President is George W. Bush's personal surrogate(a Bruce Willis movie reference) are as plentiful as the bumps on Lawrence Fishburne's daughter's ass. So the ease in which I proverbially parried and counter-punched his firebagging nonsense made me feel like Donnie Yen in "Ip Man". When it came to legislation he felt wasn't strong enough, I smiled and quietly sat through all the incendiary rhetoric about Obama grabbing his ankles around bankers and giving the health insurance companies unprompted reach-arounds - mainly because my patience was rooted in the silence I knew I'd bask in after asking him what he would have legislatively done differently. But things took a turn for the worst as soon an Miles ended his rather arduous "Obama is just like Bush" rant with what I still believe to be a vague assassination fantasy.
Since it was around 2 AM at that point I abandoned the conversation by standing up and telling the debate rubberneckers, "Ok, that is my cue to go", then I proceeded to distribute both pounds and hugs to the extremely interesting folks I had met that night. Of course giving Miles the time honored snub. The next thing I know, while I'm digging in my pockets for my car keys outside, I see Miles running up on me in my periphery - waiving his arms wildly, eventually getting in my face, screaming rather incoherently. Right when I'm about to do a Savion Glover inspired softshoe routine on his motherfucking forehead, my friend runs out the house screaming "Please, don't beat up my brother, he's high!!" I immediately say, "Shit, I'm high too, but marijuana is what kept me from making you an only child!" He then says, "No, he's smoking a lot more than weed these days" - as my friend said that Miles was grabbing my shirt so I immediately quipped "Well, you and your brother must be smoking dust if you think I'm going to let any continued act of aggression go unanswered." And that's when he sucker punched me. *POW* So I proceeded to lace him with a 5 punch combination to the face, a throat chop, a couple of kidney punches, and a kick in the gut for good measure before throwing him head first into a gigantic shrubbery of some sort.
I've been thinking about that incident ever since Robert Gibbs gave his now infamous "Professional Left" interview. As much as I questioned the strategy of him broaching the subject at all, and I did feel the term "Professional Left" would allow too many liberal commentators to conveniently play the victim - I immediately knew what Gibbs was talking about and co-signed his sentiments immediately. Two more things that also instantly came to mind: 1)I knew I'd be one in a small handful of liberals who actually had Gibbs' back on this one. and 2)That you wouldn't be able to throw a rock without hitting some liberal commentator having a rather telegraphed hissyfit over what Gibbs had to say. Even though the unpopularity of my Robert Gibbs co-signing has only shown itself to be anecdotal via twitter, the evidence of all the liberal commentators who got their delicate little feelings hurt in a rather scripted fashion was empirical like a motherfucker. The common denominators in all those videos: The using of Robert Gibbs' interview to re-litigate liberal grievances, and a convenient morphing of the Press Secretary's words into a frontal attack on the liberal base as a whole. I don't have a problem with the former, but the latter is intellectual dishonesty bordering on journalistic malpractice. Even Rachel Maddow, who I thought felt the issue was justifiably silly by her not dedicating a breathy diatribe to it on last Tuesday night's show, a person who strikes me as more of a straight shooter than most - took it upon herself to take an Obama criticism that I feel is above reproach(ending DADT) and clumsily wrapped it in what Robert Gibbs didn't say. I guess she was just following the liberal rulebook: "When it doubt, give Glenn Greenwald masturbatory material."
Robert Gibbs made it clear that he wasn't talking about garden variety liberals, just some of the chattering cable class and other influential progressives who desperately tried to convince me last week that the Press Secretary took a healthy shit in my Cheerios. More pointedly, the incessant liberal nihilism that has been masquerading as constructive criticism for the last 17 months - those are the real folks who I wholeheartedly believe Gibbs was talking about. You know, like the guy whose health care frustration prompted him to very casually float the idea of a Primary challenge to the President. Or his petulantly scripted outrage over President Obama's oil spill speech. Or the chick who thought it was a good idea to blow up a bill that improved on our health care system simply because she didn't get her precious way - then proceeding to clumsily team up with Grover Norquist. And support Erick Erickson. Then there's the guy, when he's not waxing poetic about the President's lack of genitalia and calling him a sell-out - is telling his viewers how he plans to sit on his hands come mid-term election time. Hell, just this past weekend we had certain progressives clumsily tripping over themselves like Barney Fife on mescaline in their rush to blast the President on a supposed walk-back that he never made - thus making Robert Gibbs look like a goddamned prophet.
Look, holding the President accountable is a must, no one is arguing that. But what I haven't seen from influential circles of the left if what Bob Cesca likes to call "smart accountability" - it just seems to be nothing but whining malcontents taking every opportunity imaginable to poo-poo the President's impressive string of accomplishments. They like to lecture all of us on how much of what he's gotten done lacks teeth, but then proceed to tightly cup their ears and scream like petulant 5 year olds whenever you point out what exactly the legislative realities are.(See Cenk Uygur) The funny thing is, these same people will wax poetic about the President's depressed base as if they themselves didn't have something to do with that. The same way the President shouldn't be above reproach, neither should any of his liberal critics. Sorry Keith Olbermann. Sorry Adam Green. People have regrettably noted that what Robert Gibbs participated in last week was something that folks call "Punching Hippies", the art of a Democratic administration attacking its liberal critics. Well, as I found out at the dinner party I attended a couple months back, some hippies deserved to be punched. And just like that night, many need to be drug tested.
2 comments:
- phive0phor said...
Great post. It's almost impossible to comment on it because you basically said everything I wanted to say (except for the fight scene. You still managed to get in a throat chop after all of those other punches and kicks? Damn).
I do think one of the reasons Gibbs said what he did was because of Olbermann and Maddow's complaints about the President's oil speech. I mean, when Joe Scarborough said that the Liberals should have "give[en] Obama a pass" after that speech, you know the left's criticisms were probably off base.
- Diana'sfaithinwords said...
I would not hit a hippie unless that hippie returned to the insensitive man...maybe that is what Gibson was saying liberals are returning to the insensitive man...what I want from Gibson and the president from this date on is to stand to the foolish players like Fox News and Rush and Beck call them out as the cowards they are...the message is lost when the villians are allowed to abuse the house of the president for no reason...Gibson attacked the family and hung the villains who are enemies against the house where the family resides...support much that was written by the NAPPY DIATRIBE and for some reason I feel you left out how you really felt...say as nappy as you want ...I will enjoy next time


text:
Materials Needed:
#5 knitting needles (I prefer bamboo needles, but any are fine), or needle size needed to achieve gauge
200g wool yarn (Organic Merino Wool Yarn is recommended)
Gauge: 23 stitches per 4 inches, and 29 rows per 4 inches
Cast on 35 sts (double tail method - see videos at link above) Tip:
For a stretchier cast-on, if you have larger knitting needles handy, you
can cast on with size 9 needles and then switch to the size 5 needles as
you work on row 1 below.
Row 1. knit 2, purl 1, knit 2, purl 1, repeat to end of row (this pattern will result in ending the row with 2 knit stitches)
Row 2. purl 2, knit 1, purl 2, knit 1, repeat to end of row (this pattern will result in ending the row with 2 purl stitches)
Repeat rows 1 and 2 until you have completed the 10th row
Here is what it should look like so far (this will eventually be the top front of the soaker, which will stretch out to show the ribbing when it's worn)
Row 11. knit entire row, then cast on one additional stitch by just making a loop of yarn with your thumb and putting the needle through (or use whatever method you prefer for adding one stitch to the row - I just learned the easy loop method when I was a little girl and still use it since the edges will be sewn up with the side-seams anyway)
Row 12. purl entire row, then cast on one additional stitch (or use whatever method you prefer for adding one stitch to the row)
Repeat rows 11 and 12, adding one stitch at the end of each row, until you have 53 stitches total
This is a picture of what it will look like after adding a few increase rows:
Row 28 purl across
Row 29 knit across
Rows 30-38 continue to repeat rows 28 and 29 (each row should have 53 stitches still)
After row 38, it should look like this:
Beginning with row 39, decrease 1 stitch each row (knit two stitches together at beginning of each row) until you have 29 stitches remaining (this is the front leg shaping)
After decreasing to 29 stitches, it should look like this:
Then knit/purl 4 more rows without decreasing or increasing (29 stitches each row)
Then begin to increase 1 stitch per row until you have 53 stitches (this is the back of leg shaping)
After that it should look like this (ignore my finger, I was just holding the corner to flatten the edge-curl for the photo)
I then add a little piece of yarn to mark the last row, so I can count the next 30 rows more easily.
Then knit/purl 30 rows (all with 53 stitches) - this is the back of the soaker, so if you want to add a design, this is the place to do it (you'll be starting with the bottom of your design and working upward toward the top of the soaker in the back)
Now you can begin to see the soaker take shape when you fold it like this:
Then begin decreasing one stitch per row for the waist shaping (until you have 35 stitches left)
Then, starting on what would have been a knit row, begin the ribbing as for the front top of the soaker (knit 2, purl 1) - basically repeat rows 1 through 10 above.
Use a stretchy cast off, as shown in this Word file (if you don't have Microsoft Word, please let me know and I'll try to get the instructions up on the site sooner).
Then use a large needle and yarn to sew up the side seams. When
I sew up the side seams, I occasionally (like every 3rd row or so) sew
2 rows of the back together with one of the front rows in the mid-section
(below the ribbing and waist shaping) in order to provide more room in
the back/rear of the soaker. Here is how it looks before adding the
leg ruffles/edging.
Now it's time to get out the crochet hook (or follow another pattern to find out how to add a knit edge - I prefer crochet though and it's easy to learn)
For a boy's soaker, you can add a simple crochet edge for the leg openings, or for a girls soaker, leg ruffles can be made by crocheting 3 double crochets for every row of knitting as you go around the leg edge. Note this ruffling greatly widens the leg openings (stretch the opening with your hand to get an idea of the leg opening size it will be after adding the ruffle), so first sew the side seams down a few stitches into the leg opening, or start the ruffle a little down the back of the opening and decide when you get around to the top front how much more of the side seam to sew for the leg opening to be the size you want it to be. With soakers the legs don't need to be tight against the skin to work well, and actually are probably more comfortable for the baby if they are loose anyway. If it comes out too big or small, you can pull out the crochet and try again. Happy knitting!
Here are some photos of the finished soaker (roughly 10 inches tall
and 9 inches wide)
The first time you put the soaker on the baby, it will be a bit tight, but will loosen up quickly after the first few times it is worn. I made the waist tight to start with after finding it gets way too loose with time unless this is done. I don't like adding drawstrings to my daughter's daytime soakers simply because it makes for faster diaper changes. You can add one later though if you want as the waist gets looser with time, so you might make a string now and put it in a drawer to save for later in case it is needed.
Happy Knitting!
Little knit shirt pictured
in photo at top of page
Here is the pattern for the shirt (roughly, though I'm still adjusting it each time I make one), sized for my daughter (23lbs and 31" tall):
Cotton Soft yarn (buy 2 balls to be sure and have enough yarn, though you'll only use 1+ a tiny bit more for my daughter's size shirt) You can do a web search to find the yarn somewhere, or a similar weight cotton like Stork brand.
size 5 needles
For straight needles, each side of the shirt is the same, and then sewn together. Alternating knit and purl rows for the entire front/back piece:
cast on 61 stitches and do 36 rows straight , then reduce 2 stitches every 4 rows (one at start and one at end of every 4th row), about 80 rows total for each front/back shirt piece (including the first 36 rows), ending with 39 stitches
After sewing up the side-seams to about 3" below the top, then I do
a simple crochet edge along the top back, continue with 2" (roughly 12
chains on size H or smaller crochet hook) up over the right shoulder, then
continue crochet along front edge, then up over other shoulder and tie&weave
in ends. I would try it on first to see if the top width looks okay.
Sometimes I pull out the crochet and do it tighter or looser depending
on how it looks (and to make sure it fits over her head pretty easily).
It will shrink a little in the wash.
You could also use circular needles if you want to avoid sewing up seams.
I wash these on cold in the machine and dry on hot, with all our other clothes, and they hold up really well. I like the little speckles because it conceals any slight staining (nice for a toddler, right?!)

subset: commoncrawl


text:
Monday, February 14, 2011
Genetic Profiling Uncovers New Therapeutic Approaches to Ovarian Cancer
In the United States, ovarian cancer remains the deadliest of all gynecologic malignancies and the fifth leading cause of cancer death for women. The lack of an adequate early-detection screening assay is a major factor in the high fatality rate. More than 75 percent of cases present with advanced-stage disease; of these patients, fewer than 30 percent have five-year disease-free survival rates or are cured.
Did you know
75%: the percentage of cases that present with advanced-stage disease, at which point five-year survival rates are less than 30 percent
Despite apparent differences in histologic types and grades of tumors of the ovary, standard therapies have historically treated all epithelial ovarian cancers the same: Patients have undergone surgical cytoreduction followed by platinum-based chemotherapy. Approximately 80 percent of advanced-stage ovarian cancers initially respond to this therapy, achieving a complete remission; but most recur, and patients, though living for five years or more, die with drug-resistant tumors.
Given these challenges, physicians and researchers have recognized the need to understand the biology of these tumors as the critical first step toward developing novel therapeutic approaches. Prior to joining the Massachusetts General Hospital Cancer Center in late 2008, Michael J. Birrer, MD, PhD, began leading a series of collaborative studies based at the National Cancer Institute (NCI), where he was deputy chief of the Cell and Cancer Biology Branch. Dr. Birrer, who is now director of Medical Gynecologic Oncology at the Cancer Center, began working in 2003 with NCI colleagues, along with researchers at Brigham and Women's Hospital, Harvard Medical School, Harvard School of Public Health, and Memorial Sloan-Kettering Cancer Center to systematically examine the genomic profile of ovarian epithelial tumors. Using laser capture microdissection to pull out the epithelial component of the tumors, the investigators isolated the stroma for high-density transcription profiling analysis.
The studies revealed that malignancies long considered clinically and morphologically indistinguishable are, in fact, biologically different diseases. Different histologic subtypes and grades of tumors may all originate in the ovary, but they have diverse patterns of gene expression. Buried in those patterns, researchers have discovered activated pathways and novel therapeutic targets. This work is fundamentally changing the treatment of ovarian cancer, moving the field from homogenous treatment approaches to more individualized therapies.
Differentiating Tumors by Grade
Translational Research Laboratory (TRL) technicians evaluating gene copy numbers by FISH in advanced-stage ovarian cancer.
A 2005 study by Dr. Birrer and his colleagues contributed to this strategic shift by examining the genomic composition of serous tumors of different tumor grades. (Serous cancers are the most common histologic subtype of ovarian tumors and account for approximately 70 percent of diagnosed cases.) This seminal study examined gene expression patterns for large numbers of tumors.
The findings revealed that low-grade serous tumors are an entirely distinct cancer from high-grade serous carcinomas. Even more significant, this study pointed the way toward more tailored therapies for patients with low-grade tumors. The profiling data and sequencing analysis indicated that activation of the MAP kinase pathway is an important feature of these tumors. Today, the Cancer Center is conducting trials using a single-agent MEK-inhibitor for recurrent low-grade tumors due to the nodal position of MEK in the MAP kinase pathway.
Characterizing Histologic Subtypes of Ovarian Cancers
As with tumor grade, genetic profiling suggests that endometrioid, clear cell, and mucinous tumors, which represent about 20 percent of all ovarian cancers, are biologically distinct from serous invasive tumors—and are associated with specific activated pathways that can be therapeutically targeted.
Did you know
The team of researchers systematically examined the genomic profile of ovarian epithelial tumors. Using laser capture microdissection to pull out the epithelial component of the tumors, the investigators isolated the stroma for high-density transcription profiling analysis. The studies revealed that malignancies long considered clinically and morphologically indistinguishable are, in fact, biologically different diseases.
In another 2005 study, Dr. Birrer and others published clear evidence of these biological distinctions among histologic subtypes. The study examined clear cell, serous, and endometrioid cancers of the ovary and endometrium, as well as renal clear cell cancers. The results showed that clear cell tumors were distinct from serous ovarian carcinomas and could not be statistically distinguished from clear cell tumors originating in other organs, such as the kidney.
In a study to be published in 2011, Dr. Birrer and colleagues have identified differentially expressed genes and molecular signatures that present alternative therapeutic targets for treatment of clear cell tumors. They found that, unlike serous cancers, clear cell tumors have a unique ability to survive under stress conditions and continue to grow prolifically in low-oxygen and low-glucose environments. This capability derives from the tumors' strong angiogenic signaling pathway involving upregulation of HIF 1 alpha, VEGF, and PGF and their ability to mobilize large quantities of energy-producing glycogen through activation of the enolase-mediated metabolic pathway.
Based on this discovery, Mass General Cancer Center investigators are now developing alternative therapies, such as using anti-angiogenic agents to starve the blood supply to clear cell tumors and using mTOR inhibitors to block their metabolism. Two such trials are now ongoing at the Cancer Center.
Investigators have made comparable strides in profiling mucinous tumors. A 2006 study by Dr. Birrer and researchers at NCI, Harvard Medical School, and the Harvard School of Public Health was the first to demonstrate that mucinous low malignant potential (LMP) tumors are genetically distinct from serous LMP tumors. They do not behave in the same benign manner as serous LMPs and are strongly associated with invasive serous adenocarcinomas.
The study had clear clinical implications for the pathologist and the physician, indicating that any mucinous tumor should be closely examined, as a seemingly benign borderline tumor could well have an invasive component. Expression profiling has further differentiated these tumors from serous ovarian cancer, suggesting that patients with mucinous cancers of the ovary should be treated with regimens other than carboplatin and taxol.
Cancer Center investigators are now leading an international trial for the Gynecologic Oncology Group of one such therapy using bevacizumab, an anti-angiogenic agent, in combination with the chemotherapy drug XelOx for advanced stage mucinous cancer.
Addressing Serous Tumors
Gene expression analysis of endometrial and ovarian tumors: A) Nonoverlapping gene expression profiles of endometrial and ovarian papillary serous tumors. B) Nonoverlapping gene expression profiles of endometrial and ovarian endometrioid tumors. C) Overlapping gene expression profiles of endometrial and ovarian clear cell tumors. D) Overlapping gene expression profiles of endometrial, ovarian, and renal clear cell tumors.
High-grade invasive serous cancers cause the majority of ovarian cancer deaths. Investigation is now under way at the Cancer Center to analyze these tumors, nearly 98 percent of which have p53 mutations (with many exhibiting abnormalities in the BRCA1 pathway as well), so that they typically exhibit significant DNA repair deficiencies. Such high-grade invasive serous cancers are grossly aneuploid (abnormal number of chromosomes) with a variety of chromosomal abnormalities and copy number differences that preclude straightforward clustering. Still, Cancer Center investigators have succeeded in identifying other molecular signatures that allow for the classification of subsets of serous tumors and point the way toward tailored therapeutics.
In 2008, researchers published a study generating a specific list of differentially expressed genes in serous malignancies distinguishing those patients with poor prognoses from those with good prognoses. Within those genes, the study found a number of pathways involving a variety of potential therapeutic targets.
A separate study led by Dr. Birrer and published in Cancer Cell that examined a large number of microdissected high-grade serous tumors identified a tumor-associated angiogenesis pathway. Within this pathway is a series of genes associated with angiogenesis, the most prominent being microfibril-associated glycoprotein-2 (MAGP-2). This pathway is highly expressed among a subset of serous cancers associated with poor prognosis. Tumors that exhibit overexpression of this pathway and the MAGP-2 gene have more blood vessels feeding the tumor than usual (which may explain why patients with these tumors do so poorly). Cancer Center investigators are now working to better characterize this signaling pathway to create a monoclonal antibody that can attack it. Ultimately, the work may provide vital therapeutics to treat patients with the poorest prognoses.
PARP Inhibition
Did you know
Inhibition of Poly(ADP-ribose) polymerase, or PARP, is proving to be the foundation of a variety of new targeted therapeutic approaches. A number of recent breast and ovarian cancer trials suggest that PARP inhibitors are particularly effective at treating cancer in patients with BRCA1 and BRCA2 mutations.
The researchers who are focused on the seemingly homogeneous group of high-grade serous tumors are also exploring inhibition of poly(ADP-ribose) polymerase, or PARP, which is proving to be the foundation of a variety of new targeted therapeutic approaches.
McGill University researchers in Montreal published a Human Genetics paper in 2008 that estimated that roughly 10 percent of all ovarian cancers arise in women with germline mutations of BRCA1 and BRCA2. Several years ago, investigators with the Institute of Cancer Research in London found that cells in culture with BRCA1 and BRCA2 abnormalities rely heavily on a unique repair system that is mediated by PARP, a member of a complex of DNA enzymes that repairs single-strand breaks. The work suggested that if PARP can be inhibited, the cells accumulate single-strand breaks, and over time these become double-strand breaks, which then require homologous recombination. Since homologous recombination is mediated by BRCA1 and BRCA2, cancer cells with BRCA mutations and inhibited PARP cannot efficiently repair these breaks, and they ultimately die.
This work has spawned a number of recent breast and ovarian cancer trials suggesting that PARP inhibitors are particularly effective at treating cancer in patients with BRCA1 and BRCA2 mutations. Research conducted at the Mass General Cancer Center, Beth Israel Deaconess Medical Center, and elsewhere suggests that these therapies may offer benefits for breast and ovarian cancer even beyond this subset of patients. A substantial portion of ovarian cancer patients with no germline mutation of the BRCA1 or BRCA2 genes have abnormal DNA repair function, and recently published work from several centers suggests that ovarian cancers, including those without BRCA1 or BRCA2 mutations, are highly responsive to PARP inhibitors. A Cancer Center team led by Dr. Birrer is now conducting trials of new PARP-based regimens in ovarian cancer patients.
One such set of Cancer Center trials will test a new PARP inhibitor agent (BiPar 201) plus carboplatin and gemcitabine among both platinum-sensitive and platinum-resistant patients. The chemotherapy drugs introduce single- and double-strand DNA breaks, and the PARP-inhibitor agent blocks repair of those breaks, in an attempt to promote tumor cell death.
Mass General investigators are profiling ovarian cancer cell lines with and without BRCA mutations in the hope of finding a BRCA1-like signature. It is anticipated that this work will allow physicians to identify a larger percentage of patients with high-grade serous tumors who can benefit from a PARP inhibitor coupled with chemotherapy.
A New Frontier in the Treatment of Ovarian Cancer
This work with PARP inhibitors, and the Cancer Center's genetic profiling efforts, exemplify the new clinical paradigm of tailored therapeutics in the management of ovarian cancers. The next stage will be to validate these activated pathways, particularly in high-grade serous tumors, in a much larger number of specimens. The Cancer Center is part of an international effort to test several thousand formalin-fixed, paraffin-embedded materials from clinical trial specimens. Mass General investigators hope their ability to identify genomic tumor signatures will translate into useful prognostic information that will enable them to select the appropriate therapy for particular patients.
Ultimately, these Mass General Cancer Center efforts will help bring powerful new approaches to the understanding of ovarian malignancies, and new hope to patients of this historically intractable disease.
Selected References
Key Points
- Tumors of the ovary have historically been treated homogenously, but advances in genetic profiling are revealing that ovarian cancer is, in fact, a heterogeneous disease.
- Clinical management is now beginning to recognize the disease's heterogeneity and to design trials based on genetic features of the tumor.
- Research is also revealing subsets of patients whose papillary serous tumors are driven by activated pathways that can be exploited for future therapeutics, such as PARP inhibitors.
- The next step will be to validate newly discovered activated pathways and loss of tumor suppressor gene function among larger sample sizes.
- Investigators envision a future in which large numbers of ovarian cancer patients will benefit from tailored therapies, instead of the current standard approach of one therapy fits all.
- Audeh MW, Carmichael J, Penson RT, Friedlander M, Powell B, Bell-McGuinn KM, Scott C, Weitzel JN, Oaknin A, Loman N, Lu K, Schmutzler RK, Matulonis U, Wickens M, Tutt A. (2010). Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: A proof-of-concept trial. Lancet, 376(9737): 235-44.
- Bonome T, Lee JY, Park DC, Radonovich M, Pise-Masison C, Brady J, Gardner GJ, Hao K, Wong WH, Barrett JC, Lu KH, Sood AK, Gershenson DM, Mok SC, Birrer MJ. (2005). Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary. Cancer Res, 65(22): 10602-12.
- Bonome T, Levine DA, Shih J, Radonovich M, Pise-Masison CA, Bogomolniy F, Ozbun L, Brady J, Barrett JC, Boyd J, Birrer MJ. (2008). A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res, 68(13): 5478-86.
- Wamunyokoli FW, Bonome T, Lee JY, Feltmate CM, Welch WR, Radonovich M, Pise-Masison C, Brady J, Hao K, Berkowitz RS, Mok S, Birrer MJ. (2006). Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance. Clin Cancer Res, 12(3): 690-700.
- Zorn KK, Bonome T, Gangi L, Chandramouli GV, Awtrey CS, Gardner GJ, Barrett JC, Boyd J, Birrer MJ. (2005). Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Clin Cancer Res, 11(18): 6422-30.
|Michael J. Birrer, MD, PhD
|Richard T. Penson, MD, MRCP
Massachusetts General Hospital Cancer Center
The Massachusetts General Hospital Cancer Center is among the leading cancer care providers in the United States. Known for providing customized, innovative treatments to both adults and children, the Cancer Center comprises 22 fully integrated, multidisciplinary clinical programs and a vast array of support and educational services. The Cancer Center's commitment to eradicating cancer is fueled by scientific investigation in all phases of cancer research conducted as part of one of the largest hospital-based research programs in the nation. Physician investigators conduct more than 400 clinical trials annually. The Massachusetts General Hospital Cancer Center is proud to be a founding member of the DF/HCC, a Harvard Medical School consortium designated by the National Cancer Institute as a comprehensive cancer center.
To refer a patient or for more information, please call 877-789-6100 orvisit the Cancer Center website
Other Articles in This Issue
- Watchman Device May Offer an Alternative to Warfarin for Atrial Fibrillation Patients
- New Trial Explores Two Sides of Deep Vein Thrombosis Treatment
- Surgeons Pioneer Sphincter-Sparing Treatment for Rectal Cancer—Helping Reduce Recurrence Rates
Browse the Entire Newsroom Archive


text:
This question already has an answer here:
- Why is Global State so Evil? 17 answers
I am newly learning C Programming.
When we have a C Program with lot of functions, parameter passing, calling and all - It becomes a great problem as to which variable must be declared where.
My question is: If I declare all the variables (or atleast the variables that are confusing me) as Global Variables - my problem will be solved - but is that a Good Practice?


text:
Computer forensics is the convenance of collecting, analysing and advertisement on agenda admonition in a way that is accurately admissible. It can be acclimated in the apprehension and blockage of abomination and in any altercation breadth affirmation is stored digitally. Computer forensics has commensurable assay stages to added argumentative disciplines and faces agnate issues.
About this guide
This adviser discusses computer forensics from a aloof perspective. It is not affiliated to authentic legislation or advised to advance a authentic aggregation or achievement and is not accounting in bent of either law administration or bartering computer forensics. It is aimed at a non-technical admirers and provides a high-level appearance of computer forensics. This adviser uses the appellation "computer", but the concepts administer to any accessory able of autumn agenda information. Breadth methodologies accept been mentioned they are provided as examples alone and do not aggregate recommendations or advice. Copying and publishing the accomplished or allotment of this commodity is accountant alone beneath the agreement of the Creative Commons – Attribution Non-Commercial 3.0 license
Uses of computer forensics
There are few areas of abomination or altercation breadth computer forensics cannot be applied. Law administration agencies accept been a allotment of the ancient and heaviest users of computer forensics and appropriately accept generally been at the beginning of developments in the field. Computers may aggregate a 'scene of a crime', for archetype with hacking [ 1] or abnegation of account attacks [2] or they may authority affirmation in the anatomy of emails, internet history, abstracts or added files accordant to crimes such as murder, kidnap, artifice and biologic trafficking. It is not just the agreeable of emails, abstracts and added files which may be of absorption to board but aswell the 'meta-data' [3] associated with those files. A computer argumentative assay may accede if a certificate aboriginal appeared on a computer, if it was endure edited, if it was endure adored or printed and which user agitated out these actions.
More recently, bartering organisations accept acclimated computer forensics to their account in a array of cases such as;
- Intellectual Acreage annexation
- Industrial espionage
- Employment disputes
- Artifice investigations
- Forgeries
- Matrimonial issues
- Bankruptcy investigations
- Inappropriate email and internet use in the plan abode
- Regulatory acquiescence
For affirmation to be acceptable it accept to be reliable and not prejudicial, acceptation that at all stages of this activity accommodation should be at the beginning of a computer argumentative examiner's mind. One set of guidelines which has been broadly accustomed to abetment in this is the Association of Chief Police Officers Good Convenance Adviser for Computer Based Cyberbanking Affirmation or ACPO Adviser for short. Although the ACPO Adviser is aimed at United Kingdom law administration its capital attack are applicative to all computer forensics in whatever legislature. The four capital attack from this adviser accept been reproduced beneath (with references to law administration removed):
- No activity should change abstracts captivated on a computer or accumulator media which may be after relied aloft in court.
- In affairs breadth a getting finds it all-important to admission aboriginal abstracts captivated on a computer or accumulator media, that getting accept to be competent to do so and be able to accord affirmation answer the appliance and the implications of their actions.
- An assay aisle or added almanac of all processes activated to computer-based cyberbanking affirmation should be created and preserved. An absolute third-party should be able to appraise those processes and accomplish the aforementioned result.
- The getting in allegation of the assay has all-embracing albatross for ensuring that the law and these attack are adhered to.
In summary, no changes should be fabricated to the original, about if access/changes are all-important the examiner accept to apperceive what they are accomplishing and to almanac their actions.
Live acquisition
Principle 2 aloft may accession the question: In what bearings would changes to a suspect's computer by a computer argumentative examiner be necessary? Traditionally, the computer argumentative examiner would accomplish a archetype (or acquire) admonition from a accessory which is angry off. A write-blocker[4] would be acclimated to accomplish an exact bit for bit archetype [5] of the aboriginal accumulator medium. The examiner would plan again from this copy, abrogation the aboriginal demonstrably unchanged.
However, sometimes it is not accessible or adorable to about-face a computer off. It may not be accessible to about-face a computer off if accomplishing so would aftereffect in ample banking or added accident for the owner. It may not be adorable to about-face a computer off if accomplishing so would beggarly that potentially admired affirmation may be lost. In both these affairs the computer argumentative examiner would charge to backpack out a 'live acquisition' which would absorb active a baby affairs on the doubtable computer in adjustment to archetype (or acquire) the abstracts to the examiner's harder drive.
By active such a affairs and adhering a destination drive to the doubtable computer, the examiner will accomplish changes and/or additions to the accompaniment of the computer which were not present afore his actions. Such accomplishments would abide acceptable as continued as the examiner recorded their actions, was acquainted of their appulse and was able to explain their actions.
Stages of an examination
For the purposes of this commodity the computer argumentative assay activity has been disconnected into six stages. Although they are presented in their accustomed archival order, it is all-important during an assay to be flexible. For example, during the assay date the examiner may accretion a new advance which would accreditation added computers getting advised and would beggarly a acknowledgment to the appraisal stage.
Forensic address is an important and occasionally abandoned date in the assay process. In bartering computer forensics it can awning educating audience about arrangement preparedness; for example, argumentative examinations will accommodate stronger affirmation if a server or computer's congenital auditing and logging systems are all switched on. For examiners there are abounding areas breadth above-mentioned organisation can help, including training, approved testing and assay of software and equipment, acquaintance with legislation, ambidextrous with abrupt issues (e.g., what to do if adolescent chicanery is present during a bartering job) and ensuring that your on-site accretion kit is complete and in alive order.
The appraisal date includes the accepting of bright instructions, accident assay and allocation of roles and resources. Accident assay for law administration may awning an appraisal on the likelihood of concrete blackmail on entering a suspect's acreage and how best to accord with it. Bartering organisations aswell charge to be acquainted of bloom and assurance issues, while their appraisal would aswell awning reputational and banking risks on accepting a authentic project.
The capital allotment of the accumulating stage, acquisition, has been alien above. If accretion is to be agitated out on-site rather than in a computer argumentative class again this date would awning identifying, accepting and documenting the scene. Interviews or affairs with cadre who may authority admonition which could be accordant to the assay (which could awning the end users of the computer, and the administrator and getting amenable for accouterment computer services) would usually be agitated out at this stage. The 'bagging and tagging' assay aisle would alpha actuality by sealing any abstracts in altered tamper-evident bags. Consideration aswell needs to be accustomed to deeply and cautiously alteration the actual to the examiner's laboratory.
Analysis depends on the specifics of anniversary job. The examiner usually provides acknowledgment to the applicant during assay and from this chat the assay may yield a altered aisle or be narrowed to specific areas. Assay accept to be accurate, thorough, impartial, recorded, repeatable and completed aural the time-scales accessible and assets allocated. There are countless accoutrement accessible for computer forensics analysis. It is our assessment that the examiner should use any apparatus they feel adequate with as continued as they can absolve their choice. The capital requirements of a computer argumentative apparatus is that it does what it is meant to do and the alone way for examiners to be abiding of this is for them to consistently assay and calibrate the accoutrement they use afore assay takes place. Dual-tool assay can affirm aftereffect candor during assay (if with apparatus 'A' the examiner finds achievement 'X' at breadth 'Y', again apparatus 'B' should carbon these results.)
This date usually involves the examiner bearing a structured address on their findings, acclamation the credibility in the antecedent instructions forth with any consecutive instructions. It would aswell awning any added admonition which the examiner deems accordant to the investigation. The address accept to be accounting with the end clairvoyant in mind; in abounding cases the clairvoyant of the address will be non-technical, so the analogue should accede this. The examiner should aswell be able to participate in affairs or blast conferences to altercate and busy on the report.
Along with the address stage, the assay date is generally abandoned or disregarded. This may be due to the perceived costs of accomplishing plan that is not billable, or the charge 'to get on with the next job'. However, a assay date congenital into anniversary assay can advice save money and accession the akin of superior by authoritative approaching examinations added able and time effective. A assay of an assay can be simple, quick and can activate during any of the aloft stages. It may awning a basal 'what went amiss and how can this be improved' and a 'what went able-bodied and how can it be congenital into approaching examinations'. Acknowledgment from the instructing affair should aswell be sought. Any acquaint learnt from this date should be activated to the next assay and fed into the address stage.
Issues adverse computer forensics
The issues adverse computer forensics examiners can be torn down into three ample categories: technical, acknowledged and administrative.
Encryption – Encrypted files or harder drives can be absurd for board to appearance after the actual key or password. Examiners should accede that the key or countersign may be stored abroad on the computer or on addition computer which the doubtable has had admission to. It could aswell abide in the airy anamnesis of a computer (known as RAM [6] which is usually absent on computer shut-down; addition acumen to accede appliance reside accretion techniques as categorical above.
Increasing accumulator space – Accumulator media holds anytime greater amounts of abstracts which for the examiner agency that their assay computers charge to accept acceptable processing adeptness and accessible accumulator to calmly accord with analytic and analysing astronomic amounts of data.
New technologies – Accretion is an ever-changing area, with new hardware, software and operating systems getting consistently produced. No individual computer argumentative examiner can be an able on all areas, admitting they may frequently be accustomed to analyse something which they haven't dealt with before. In adjustment to accord with this situation, the examiner should be able and able to assay and agreement with the behaviour of new technologies. Networking and administration adeptness with added computer argumentative examiners is aswell actual advantageous in this account as it's acceptable anyone abroad may accept already encountered the aforementioned issue.
Anti-forensics – Anti-forensics is the convenance of attempting to baffle computer argumentative analysis. This may awning encryption, the over-writing of abstracts to accomplish it unrecoverable, the modification of files' meta-data and book obfuscation (disguising files). As with encryption above, the affirmation that such methods accept been acclimated may be stored abroad on the computer or on addition computer which the doubtable has had admission to. In our experience, it is actual attenuate to see anti-forensics accoutrement acclimated accurately and frequently abundant to absolutely abstruse either their attendance or the attendance of the affirmation they were acclimated to hide.
Legal issues
Legal arguments may abash or abstract from a computer examiner's findings. An archetype actuality would be the 'Trojan Defence'. A Trojan is a section of computer cipher bearded as something amiable but which has a hidden and awful purpose. Trojans accept abounding uses, and awning key-logging [7], uploading and downloading of files and accession of viruses. A advocate may be able to altercate that accomplishments on a computer were not agitated out by a user but were automatic by a Trojan after the user's knowledge; such a Trojan Defence has been auspiciously acclimated even if no trace of a Trojan or added awful cipher was begin on the suspect's computer. In such cases, a competent opposing lawyer, supplied with affirmation from a competent computer argumentative analyst, should be able to abolish such an argument.
Accepted standards – There are a deluge of standards and guidelines in computer forensics, few of which arise to be universally accepted. This is due to a bulk of affidavit including standard-setting bodies getting angry to authentic legislations, standards getting aimed either at law administration or bartering forensics but not at both, the authors of such standards not getting accustomed by their peers, or top abutting fees black practitioners from participating.
Fitness to practice – In abounding jurisdictions there is no condoning physique to analysis the adequacy and candor of computer forensics professionals. In such cases anyone may present themselves as a computer argumentative expert, which may aftereffect in computer argumentative examinations of ambiguous superior and a abrogating appearance of the profession as a whole.
Resources and added reading
There does not arise to be a abundant bulk of actual accoutrement computer forensics which is aimed at a non-technical readership. About the afterward links at links at the basal of this page may prove to be of absorption prove to be of interest:
1. Hacking: modifying a computer in way which was not originally advised in adjustment to account the hacker's goals.
2. Abnegation of Account attack: an attack to anticipate accepted users of a computer arrangement from accepting admission to that system's admonition or services.
3. Meta-data: at a basal akin meta-data is abstracts about data. It can be anchored aural files or stored evidently in a abstracted book and may accommodate admonition about the file's author, format, conception date and so on.
4. Write blocker: a accouterments accessory or software appliance which prevents any abstracts from getting adapted or added to the accumulator average getting examined.
5. Bit copy: bit is a abbreviating of the appellation 'binary digit' and is the axiological assemblage of computing. A bit archetype refers to a consecutive archetype of every bit on a accumulator medium, which includes areas of the average 'invisible' to the user.
6. RAM: Random Admission Memory. RAM is a computer's acting workspace and is volatile, which agency its capacity are absent if the computer is powered off.
7. Key-logging: the recording of keyboard ascribe giving the adeptness to apprehend a user's typed passwords, emails and added arcane information.


text:
All Wines
Feel free to browse through our entire wine list, but with around 250 to choose from, you'd probably need to set aside a whole evening. Much better to use the filters below, which allow you to sort the wines alphabetically or by price, or filter them by type, grape, country, style, price range or even the dishes you're planning to drink them with.
Remember also to check out our wonderful wine deals, which offer seasonal wines at VIP prices whether you're a member or not. Or browse our unique selection of fine wines from around the world. We hope the quality of our wines proves that great wines can be reasonably priced – if you know where to look.
Tokara Elgin Reserve Sauvignon Blanc 2018, Walker Bay
A complex South African Cape Sauvignon Blanc packed with flavours of crunchy green fruits and a crisp lingering finish. Read More.
Regular Price: £17.99
Special Price £15.99
- ADD 2 - SAVE 13% - £13.99 a bottle
Gabriëlskloof Sauvignon Blanc 2018, Bot River
Pretty smart South African Sauvignon Blanc this. No escaping the cut grass, kiwi fruit aromas - there in spades. Followed through by lush gooseberry, lime and zesty fruit, with plenty of depth of flavour too Read More.£12.99
Château Gris 1er Cru Nuits-Saint-Georges 2011, Albert Bichot
Available to buy as a single bottle
Classic Côte de Nuits from Burgundian great Albert Bichot - let the wine do the talking. Read More.£49.95
- ADD 2 - SAVE 28% - £35.99 a bottle
Stanton & Killeen Classic Rutherglen Muscat NV Australia 37.5cl
Buy 2 for £25.98 - like Christmas pud in a glass
Powerful, rich and sweet. Words don't do justice, buy it! Read More.
Regular Price: £17.99
Special Price £14.99
- ADD 2 - SAVE 14% - £12.99 a bottle
Magie d'Or Pacherenc Du Vic-Bilh 2013 50cl
Buy 2 for £14.98 - sweet white wine at an unmissable price
A luscious, fresh sweetie from South-West France. One sip and you're hooked... Read More.
Regular Price: £9.99
Special Price £8.49
- ADD 2 - SAVE 12% - £7.49 a bottle
Château De Santenay Beaune 1er Cru Clos Du Roi 2015
Available to buy as a single bottle
Spoil yourself (or another) with this stunning Premier Cru rich with red berry fruit and spice. Read More.£38.99
- ADD 2 - SAVE 16% - £32.99 a bottle
Domaine du Pavillon Aloxe-Corton 2015, Albert Bichot
Available to buy as a single bottle
Elegant, with a hint of spice. Beautiful Côte de Beaune with ripe tannins and a hint of sweetness. Read More.£39.50
- ADD 2 - SAVE 27% - £28.99 a bottle
Santenay 1er Cru Clos Rousseau 2015, Albert Bichot
Available to buy as a single bottle. Buy 2 for £43.98 - which will make the Christmas turkey very special indeed
Intense red fruit character, good structure and a long fruity finish. Read More.
Regular Price: £29.90
Special Price £24.99
- ADD 2 - SAVE 13% - £21.99 a bottle
Jean Loron Pouilly-Fuissé Les Vieux Murs 2015
Available to buy as a single bottle
A mellow mouthful, with honeyed apple fruit and a whip of citrus just for luck. Read More.£23.99
- ADD 2 - SAVE 17% - £19.99 a bottle
Quinta Do Infantado LBV 2013
Top-notch Port from a family-owned estate with a history going back to 1816 when it was founded by a Portuguese prince who went on the become the first emperor of Brazil. Rich, smooth, and massively satisfying fortified wine Read More.
Regular Price: £18.95
Special Price £15.99
Domaine du Pavillon Meursault 2016, Burgundy
Available to buy as a single bottle
This beautiful Meursault is made from grapes sourced from five spots in the Domain Pavilion vineyards with different but complementary characteristics. Read More.
Regular Price: £58.50
Special Price £49.99
- ADD 2 - SAVE 11% - £44.99 a bottle
Volnay 2015, Albert Bichot
Available to buy as a single bottle. Buy 2 for under £60 - the world's best Pinot Noir region in the reach of us mere mortals
Elegant wines that are considered to be a very feminine style of Burgundian Pinot Noir. Match this with rich, creamy cheeses. Read More.£49.50
- ADD 2 - SAVE 40% - £29.99 a bottle


text:
First Look Program
Take your business to new heights
WeWork First Look Program is your exclusive access to one-on-one, quarterly guidance from our team of experts. You'll receive a dedicated Growth Specialist who will discuss your workspace needs and provide support to help your company rise to the next level. Plus, you'll be the first to learn about new locations in your city, so you can reserve your spot, before anyone else. Whether you're establishing a 1000-person HQ, looking to scale your current office, test a new market, or grow your global team, we're here to make success simple for you. We handle everything, from sourcing real estate to designing, building, and operating your perfect workspace. We eliminate the hassle so you can focus on what matters most: your business.


text:
Slugcat pups, of course, come from Rain World, the gorgeously animated sci-fi survival-platformer. They were shown off properly for the first time in a new trailer which, in turn, was part of the latest update to the game's Kickstarter project.
Take a look:
The campaign itself is nearing its end, with some pretty good results: the developers managed to collect more than twice the amount of money they asked for. They're planning to turn the extra funds towards moving the game to a new coding language, giving it a lot of polish, and also porting it to Linux.
New Slugcat 'PUPS!' Video! [Kickstarter]


text:
Ark: Survival Evolved Taming Calculator
Ark: Survival Evolved Taming Calculator
-2 points Encountering
Never challenge an alpha t rex alone
More Therizinosaurus Encountering Tips
1041 points Encountering
A level 10 did 4000 damage to our level 137 Giga, and almost killed a level 200+ Argie. Be very very careful with these guys.
964 points Encountering
You do not find tickle chicken. Tickle chicken finds you.
330 points Encountering
All those years of PTSD from the tickle monster when you were little will suddenly come back when you meet one of these
291 points Encountering
I got DESTROYED by a mate boosted level 125 while wearing Ascendant & Mastercraft Flak Armor (1500 Total Armor). Avoid these on foot at all costs. If your character doesn't have high movement speed, you probably won't survive. The Ark Freddy Krueger
277 points Encountering
This monster will chase you if you get too close! So be sure to have a fast way out or ranged weaponry. (It has a fairly decent aggro range, too!)


text:
Product Description
Round shaped green semi precious Carracite Picture Jasper designer cabochon 30.5 mm in diamter and 4.5 mm thick.
Carrasite Jasper is a nice porcelain gemstone jasper found in the same area as the famous Morrisonite and it looks very similar to it.
Cabochons are stones cut for jewelry and are measured in mm. One inch is equal to about 25 mm.
Shipping terms: Cabochons are shipped First Class within the U.S. for FREE. You can upgrade to Priority Mail Small Flat Rate Box for $5.00.
We offer First Class International shipping for $5.00. First Class usually takes from 2 weeks up to 8 weeks internationally and it is NOT tracked. You can choose to upgrade to Priority Mail for $20.00 to Canada or $22.00 anywhere else.


text:
[np_storybar title="Recent PGA Tour success hurts long putter" link="http://sports.nationalpost.com/2012/07/25/recent-pga-tour-wins-could-doom-long-putter/"%5D
LANCASTER, Ont. — A caddy for a 10-year pro was standing on the side of the practice green at Hamilton Golf and Country Club on Tuesday afternoon, and he pulled a TaylorMade belly putter from one of the bags of equipment that are scattered about to entice prospective PGA users.
He stood over an imaginary ball, took a few strokes, shook his head slightly and muttered, to no one in particular, "It's cheating."
This is a not uncommon sentiment among players, loopers and coaches on the PGA Tour, and one that has taken on added significance with the news on Monday that discussions about whether to ban long putters are, according to R&A chief executive Peter Dawson, "firmly back on the radar."
So I chased the caddy down and asked him about his mutterings. He didn't want to be seen as speaking for his pro — a wise discretion, admittedly — but when it was suggested that opinion was mixed on a possible ban, he smiled.
THOUSAND OAKS, Calif. — Golf's governing bodies, worried that players will turn to long putters as an advantage instead of a last resort, proposed a new rule Wednesday that would ban the putting stroke used by three of the last five major champions.
The Royal & Ancient Golf Club and the U.S. Golf Association said the rule would not outlaw belly putter or broom-handle putters, only the way they are currently used. The proposed rule would make it illegal for golfers to anchor the club while making a stroke and not take effect until 2016.
"More players are using it, and instructors are saying this is a more efficient way to putt because you don't have to control the whole stroke," USGA executive director Mike Davis said. "The game has been around for 600 years. Fundamentally, we don't think this is the right way to go."
Orville Moody won the 1989 U.S. Senior Open using a long putter that he held against his chest, allowing for a pendulum motion. Paul Azinger won the 2000 Sony Open with a putter that he pressed into his belly. Long putters began getting serious attention last year when Keegan Bradley became the first player to win a major with a belly putter at the PGA Championship. This year, Webb Simpson won the U.S. Open and Ernie Els won the British Open using belly putters.
"Our objective is to preserve the skill and challenge," R&A chief executive Peter Dawson said. "This rule is not performance related. This is about defining the game defining what is a stroke."
The long putters are not being banned. The rule relates to the actual stroke, not the equipment. Players can use a broom putter as long as it is not anchored to the chest.
Davis and Dawson said the catalyst for the new rule was not who was winning tournaments, but the number of players switching to long putters.
Their research showed no more than 4% of golfers used the clubs for several years. It went to 6% in 2006, and then to 11% in 2011, with some PGA Tour events having as much as 20% of the players using the long clubs. There was no empirical data to suggest a long putter made golf easier. Carl Pettersson (No. 21) and Bradley (No. 27) were the only players among the top 30 in putting this year on the PGA Tour who used long putters.
"We don't think putting in an anchored way is easy. You have to learn how to do it," Dawson said. "But it takes one of the potential frailties out of the stroke … We have to retain the skill and challenge inherent in golf."
The R&A and USGA will take comments for three months on the proposed rule before it is approved. Because the Rules of Golf are updated every four years, any ban on the anchored stroke would not take effect for another four years.
The PGA Tour, European Tour and LPGA Tour said it would evaluate the proposed rule with its players. The PGA Tour has a mandatory players meeting in San Diego at the end of January. The PGA of America, meanwhile, said it was concerned that such a ban would drive people from the game.
"As our mission is to grow the game … we are asking them to seriously consider the impact this proposed ban may have on people's enjoyment of the game and the overall growth of the game," PGA president Ted Bishop said.
We don't think putting in an anchored way is easy. You have to learn how to do it
The decision figures to be divisive at the highest level.
Tim Clark of South Africa and Pettersson have used broom putters their entire careers, and they have suggested a new rule would affect their livelihoods.
Dawson said he was hopeful the players would understand the decision for the proposed ban on anchoring. Davis said potential lawsuits were never considered.
"Shame on us if we're scared of litigation in doing the right thing," Davis said.


text:
Free shipping over € 149
Free shipping over € 149
Since its very beginning, many of the most interesting, successful and distinctive products in Alessi's history have been variations on the theme of "containing". The Babà family of multipurpose containers - which includes jars, flower vases, wastepaper baskets, umbrella stands, stools and even coolers for bottles of all sizes - is an elegant, pleasing and intelligent collection.
Born in La Spezia in 1954, Stefano as an architect and designer was taught by Buti at Florence University. In the early 80's he founded the King-Kong Production Group along with Guido Venturini. His explosive talent enables him to embody a complex system of 'affective codes' in his projects. This great approach won him the title of 'Super & Popular' designer in the 90's. A technical designer par excellence he has industrial design in his DNA and the capacity to understand public sentiment like no other designer mentioned in this catalogue. His projects began with the "Girotondo" (1989 designed with Guido Venturini) and the first transparent objects in plastic from the "Family Follows Fiction" series (1993). There is a huge number of his items in the "Officina Alessi", "Alessi" and "A di Alessi" catalogues. www.stefanogiovannoni.it


text:
2/25/2012 4:06pm, #1
- Join Date
- Apr 2010
- Location
- Posts
- 11,108
- Style
- BJJ/Judo/MT
Review - Concealment option: Belly Band
I've been wearing my belly band for about 4 months, now, and I've got to say: I love it!
What is a belly band, you ask? Well, it's basically a big piece of elastic with pouches sewn on, and typically a large hook-and-loop fastener.
It can be worn around the belly (hence the name), or also below the belt-line as a replacement for a dedicated IWB holster. I've also had success wearing mine up around the rib cage, though this location makes deployment a tad difficult.
This makes it a very flexible piece of gear, and at a fraction of the cost of a form-fitting IWB holster. Which brings up another point - since it's elastic, it's capable of fitting multiple firearms! Also note that because it's just a large piece of elastic material, many bands can be turned inside-out for alternate-handedness.
Belly bands are available from a myriad of suppliers, in different styles and configurations. Here's mine - a simple, right-hand draw with single clip pocket. I grabbed mine off Amazon (because I was ordering some other stuff from there and wanted to save on shipping) for $24.95.
Options you may find include pouches for multiple weapons, retention straps, and colors. Many models offer two or three weapon sizes, and multiple waist ranges.
I typically wear mine around the belly, so that the gun sits right behind my kidney. Since it's pressed tight against me, I find this to be fairly comfortable for sitting, including in the car. This is Florida - I typically don't wear an undershirt, but on the occasions I have, I did find relief from minor irritation from the seams, especially in the Velcro area.
Now you see it...
Now you don't.
As long its worn under a loose shirt, even a skinny stick like me can conceal comfortably, with one caveat - bending over or other motions that cause your shirt to tighten will allow the gun to "print," so take care, especially in locales that have strict concealment requirements.
The belly band allows for rapid deployment, especially when worn on the belly. Because there's no belt clip, it can be a better concealment option than IWB holsters. Re-holstering is a bit of work, typically requiring two hands. But, honestly, if you're going to be deploying your weapon "for real," re-holstering is a minor concern.
Keep it in your pants!
To sum up, the belly band is an inexpensive, flexible concealment platform. Everyone should have one!R.I.P. Internet. 2015-2017
How to Fix the Government | Kel-Tec PF9 | Behind the Moustache | Ruger P95 | Jimenez JA22 | Belly Band | How do spelchek? | Why carry concealed? | MABS Tools & Techniques | Submessenger's Ultimate Free Software List | How do necro? | The Accuracy Paradox | Submessenger's YT
2/27/2012 10:30am, #2
- Join Date
- Dec 2010
- Posts
- 17
- Style
I've seen something similar, except it strapped over the chest instead of the belly. They look like the dude is wearing a bra underneath. Good for when you need to conceal underneath a tucked in shirt, and you can conceal a decent size pistol with the right shirt (guy I saw concealed a kimber ultra carry with it). Not quite sure it'd be easy to draw from though.


text:
In the first Pinger battle, it's suggested that it has a weak point at the back, and you should concentrate your fire there. This is shown visually too, by the back parts being red, like other enemies' weak points. But when I attack later Pingers (in 'Soldier' difficulty), it seems that it takes 6 JAW hits to kill it, regardless of where I hit it. Is it just that I'm not managing to hit the right point? Does the weak point only make a difference at harder difficulties? Or perhaps the weak point only applies to bullet weapons, not the JAW?
What's really going on? I'm struggling on my Pinger battles (especially in 'Power Out') because I spend ages trying to get around behind it, seemingly to no avail. I'm on PC, with the non-Steam version, if that makes a difference.


text:
Shipping to: România
Best Seller New
Buildable effect powder highlighter.
The new sensory texture of this powdered oil is creamy and easy to blend.
Its innovative formula highlights the face with a velvety touch. Its blend of softening ingredients creates an exceptionally soft and gliding powder that leaves a long lasting feeling of comfort. On contact with the skin, it gives a flawless finish with a soft focus effect.
The high concentration of pearls helps to create points of light and guarantees optimum colour release with a buildable effect for every type of makeup, from soft contouring to a more pronounced effect.
Available in three different shades for all complexions.
Dermatologically tested.
Highlights the skin on the face with a touch of light.
Apply Glow Fusion Powder Highlighter with the correct brush for each part of your face:
- Face 08 Precision Powder Brush for the centre of the forehead, the bridge of the nose, the top of the cheekbones and the chin;
- Face 12 Powder Fan Brush to finish the top of the cheekbones, the nose and forehead;
- Eyes 52 Shader Brush for the eyebrow arch, the inner corner of the eye and the Cupid's bow.
The iconic and elegant pack with a metallic finish is handy and compact with an internal mirror, perfect for keeping with you throughout the day for quick touches.
The cost varies depending on the delivery service and the destination country of the order. For more details see the "Delivery information and costs" page.
More information
Shipping times may vary depending on the service chosen. In the countries served by Swiss Post (Asendia) only, delivery takes an average of 6-7 working days (up to a maximum of 10) from the order being dispatched. In countries where the Skynet service is also available, the shipping time is 2-4 days after being dispatched by courier. More information
Purchases made on KIKO are secure and guaranteed. All information relating to payments, including personal information and credit card information, is protected through an advanced encrypted data transmission system. Under no circumstances will KIKO file your credit card number, nor will it use or keep the information you provided on its own systems.
You have 14 business days from the date you receive the items in which to exercise your right to return the goods. Please let Customer Service know about any problems relating to the goods received.
To use a promotional code, select "Have you got a promotional code?" on the shopping cart page and insert the characters indicated in the appropriate field. If your code is inserted correctly, the amount and/or content of the Shopping Cart will be recalculated based on the promotion applied.
Setting, concealing baked powder in four colours
juste waouw
Mai più senza
Très bien
Beau petit highlighter


text: Lib Abrena was a classic Filipino comics artist. Together with Os. del Rosario, he created what was presumably the first costumed superhero in the Philippines, 'Ipo-Ipo', that debuted in Magasin ng Pagsilang in April 1947. He was also present in Liwayway Magazine with the cartoon series 'Mga Sulyap Sa Buhay'.