text:
Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00382070
Recruitment Status : Active, not recruiting
First Posted : September 28, 2006
Last Update Posted : January 9, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known whether letrozole is more effective than a placebo in treating patients with hormone receptor-positive breast cancer.
PURPOSE: This randomized phase III trial is studying letrozole to see how well it works compared with a placebo in treating postmenopausal women who have received hormone therapy for hormone receptor-positive breast cancer.
|Condition or disease
|Breast Cancer
|Drug: Letrozole Other: Placebo
|Phase 3
- Determine whether or not prolonged adjuvant hormonal therapy comprising letrozole vs placebo will improve disease-free survival of postmenopausal women with estrogen receptor-positive and/or progesterone receptor-positive breast cancer who have completed 5 years of hormonal therapy with 5 years of an aromatase inhibitor (AI) or 5 years of a combination of up to 3 years of tamoxifen citrate followed by an AI.
- Compare the disease-free survival of patients treated with these regimens.
- Compare overall survival of patients treated with these regimens.
- Compare breast cancer-free interval of patients treated with these regimens.
- Compare distant recurrence in patients treated with these regimens.
- Compare the incidence of osteoporotic-related fractures (e.g., Colles', hip, and spine) in these patients treated with these regimens.
- Compare the incidence of arterial thrombotic events in patients treated with these regimens.
OUTLINE: This is a double-blind, multicenter, placebo-controlled, randomized study. Patients are stratified according to pathologic nodal status (negative vs positive), adjuvant tamoxifen citrate therapy (yes vs no), and lowest bone mineral density T score for lumbosacral spine, total hip, or femoral neck (> -2.0 vs ≤ -2.0 standard deviation). Patients are randomized to 1 of 2 treatment arms.
- Group I: Patients receive oral placebo once daily.
- Group II: Patients receive oral letrozole once daily.
In both arms, treatment continues for up to 5 years in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed annually.
PROJECTED ACCRUAL: A total of 3,840 patients will be accrued for this study.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|3966 participants
|Intervention Model:
|Parallel Assignment
|Double (Participant, Investigator)
|Primary Purpose:
|Official Title:
|A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women With Hormone Receptor Positive Breast Cancer
|Study Start Date :
|August 2006
|Actual Primary Completion Date :
|January 2016
|Estimated Study Completion Date :
|December 2019
Experimental: Group 2 Letrozole
Patients receive oral letrozole once daily for up to 5 years.
Drug: Letrozole
Letrozole 2.5 mg taken orally once daily for 5 years
Placebo Comparator: Group 1 Placebo
Patients receive oral placebo once daily for up to 5 years.
Other: Placebo
Placebo tablet taken orally once daily for 5 years
- Disease-free survival [ Time Frame: Time from randomization to local recurrence following mastectomy or lumpectomy (IBTR), regional recurrence, distant recurrence, second primary cancer or death from any cause prior to recurrence or second primary cancer. ]
- Overall survival [ Time Frame: Time from randomization to any death ]
- Breast cancer-free interval [ Time Frame: Time from randomization to recurrence or contralateral second primary cancer ]
- Distant recurrence [ Time Frame: Time from randomization to distant recurrence of breast cancer. ]
- Osteoporotic-related fractures [ Time Frame: Incidence of osteoporotic-related fractures (Colles', hip, and spine). ]
- Arterial thrombotic events [ Time Frame: Incidence of arterial thrombotic events (CTCAE v. 3.0 grades 3, 4, or 5 cardiac ischemia/infarction, CNS cerebrovascular ischemia, peripheral arterial ischemia, and visceral arterial ischemia [nonmyocardial]) ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 120 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Eligibility Criteria
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (0 = fully active, able to carry on all pre-disease performance without restriction; 1 = restricted in physically strenuous activity but ambulatory).
- Patients must be postmenopausal at the time of randomization. (Note: Premenopausal or perimenopausal women requiring therapy with luteinizing hormone-releasing hormone [LHRH] analogs to suppress ovarian function are not eligible.) For study purposes, postmenopausal is defined as: age 56 or older with no spontaneous menses for at least 12 months prior to study entry, or age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) AND with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standards, or a prior documented bilateral oophorectomy.
- The patient must have remained disease-free from the time of initial breast cancer diagnosis until the time of randomization.
- The patient must have had histologically-confirmed invasive carcinoma of the breast by diagnostic core needle biopsy or by final pathologic evaluation of the surgical specimen.
- Patients who received neoadjuvant chemotherapy must have been clinical Stage I, II, or IIIA. For patients who received adjuvant chemotherapy, the primary tumor must have been T1-3 on pathologic evaluation and ipsilateral nodes must have been pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b.
- The primary tumor must have been estrogen receptor (ER)-positive and/or progesterone receptor (PgR)-positive. (Patients who had a tumor that was considered to be borderline for hormone receptor positivity and who were treated with tamoxifen and/or an aromatases inhibitor (AI) are eligible for this study.)
- Patients must have undergone either a lumpectomy with axillary nodal staging followed by breast radiotherapy or a total mastectomy with axillary nodal staging. (Acceptable axillary nodal staging procedures include sentinel node biopsy alone, if sentinel nodes were negative on hematoxylin and eosin (H&E) staining.)
- The duration of the patient's hormonal therapy following breast cancer diagnosis must have been 57-63 months from the first dose regardless of the number of missed doses. Hormonal therapy must have consisted of an AI or a combination of up to 3 years of tamoxifen followed by an AI. Tamoxifen may not have been given during years 4 and 5 of the 5 years of adjuvant hormonal therapy. (Note: Patients must discontinue their adjuvant AI therapy at the time of randomization.)
- Optional Letrozole Registration Program for patients who have not yet completed 5 years of hormonal therapy. (Note: As of September 5, 2008, the optional NSABP B-42 Registration Program closed to patient enrollment. Accrual and data collection for the NSABP B-42 randomized treatment trial continues as planned.) In order to have a predominantly letrozole-treated population for B-42 study entry, patients who have had a minimum of 2 years of hormonal therapy and who are currently on tamoxifen (for up to 3 years) or an AI may be offered letrozole at no cost until they complete 5 total years of initial adjuvant hormonal therapy.
- B-42 randomization must be within 6 months following completion of 5 years (57-63 months) of initial adjuvant hormonal therapy.
At the time of randomization, the patient must have had the following: history and physical exam within 3 months demonstrating no findings suggestive of recurrent breast cancer; bilateral mammogram within 1 year (unilateral if patient had a mastectomy); mammogram not required if patient had a prophylactic contralateral mastectomy; bone mineral density (BMD) testing within 1 year; and fasting lipid profile (total cholesterol, LDL-C, HDL-C, and triglycerides) with a total cholesterol value less than or equal to grade 1 (according to CTCAE v3.0), with or without cholesterol-lowering therapy.
- within 1 year if the patient has a history of hypercholesterolemia controlled with cholesterol-lowering therapy and/or therapeutic lifestyle changes or if the patient has a history of one or more of the following risk factors for future cardiovascular events: diabetes, hypertension, obesity, tobacco use, hypertriglyceridemia, documented coronary artery disease, or family history of premature coronary heart disease.
- within 2 years for all other patients.
Ineligibility Criteria
- Patients with one or more of the following conditions will be ineligible for this study:
- History of non-traumatic osteoporotic fracture of wrist, hip, or spine.
- Diagnosis of bilateral breast cancer including ductal carcinoma in situ (DCIS)[(synchronous or metachronous].
- Other malignancies unless the patient is considered to be disease-free for 5 or more years prior to randomization, and is deemed by their physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: carcinoma in situ of the cervix, colon carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinoma of the skin.
- Sex hormonal therapy, e.g., estrogen- or progesterone-replacement therapy or oral contraceptives. These patients are eligible only if this therapy is discontinued prior to randomization.
- Therapy with any hormonal agent such as raloxifene for management of osteoporosis. Patients are eligible only if these medications are discontinued prior to study entry.
- Administration of any investigational agent within 30 days before study entry.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00382070
Show 806 Study Locations
|Principal Investigator:
|Norman Wolmark, MD
|NSABP Foundation Inc
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|NSABP Foundation Inc
|ClinicalTrials.gov Identifier:
|NCT00382070 History of Changes
|Other Study ID Numbers:
U10CA012027 ( U.S. NIH Grant/Contract )
|First Posted:
|September 28, 2006 Key Record Dates
|Last Update Posted:
|January 9, 2019
|Last Verified:
|December 2018
stage I breast cancer
stage II breast cancer
stage IIIA breast cancer
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Antineoplastic Agents
Aromatase Inhibitors
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Estrogen Antagonists
Hormone Antagonists


text:
Dev Channel Update for Chromebooks
34 comments :
I know Cr-48 isn't getting this version, but does that mean 18 is the last version of the Cr-48 or is 20 planned for Cr-48?
And why? Were the minimum system requirements for Chrome OS upped past the Cr-48?
Thanks for the update.
Google, are you killing off support for CR48?
@mxx - No, nothing like that. @The_MAZZTer No, we'll only be skipping the Chrome 19 update for CR-48 users due to platform considerations. To be clear, we're still committed to supporting CR-48 devices and they will continue to receive security and critical updates as necessary. Samsung Series 5 and Acer AC700 Chromebooks will receive this update and we'll bring CR-48 devices back onto the release train after this release. Thanks for reaching out and sorry for the inconvenience!
Orit, just to clarify, what do you mean by "this release"? Just 19.0.1048.17 or all of Chrome 19?
What a bummer - I just booted up my CR48 to test things out.....
@mxx, skipping for all of Chrome 19 for CR-48 users.
Why not for cr-48???
I'm still waiting for them to merge Android with Chrome OS...
Orit: Can you expound on the platform considerations that are causing you guys to exclude the CR-48? Is there some sort of hardware restriction that causes the CR-48 to be excluded? I'm sure you understand that for loyal beta testers who submitted countless bug reports to the project thus far this is quite a blow.
I would also like to chime in about the CR48 program. I was happily expecting to see a new update on mine after the announcement of this until I read the fine print.
Is there a hardware limitation that our CR48's simply can't overcome for ChromeOS 19, or is it a build question?
While I respect your decision, it seems odd to exclude the entire group of beta testers outside the garden of Google that signed up for the original app development and testing of the OS.
is there any way to install this software on a non-chromebook, like as a dual boot option?
Well this is saddening. It's really a shame to see support getting killed off for your first and most loyal testers. I hope Google can figure out some kind of lightweight build for the Cr-48.
Google has simply skipped cr-48 for build 19. They have said that they will continue supporting cr-48 in later builds, but simply not in this one.
- This comment has been removed by a blog administrator.
Could anyone tell me if this version of Chrome OS is still 32 bits or has been switched to 64 bits? The content of "uname" in "chrome://system" will be enough.
(I can't test on my computer because I have a custom system that may break badly if the kernel is now 64 bits, and I really need my custom system in the next few days)
Thanks !
Aura is fantastic! It looks great, and I haven't seen any impact on performance. Thanks!!
Seriously? Can you expand on why the CR-48 will not get this update? When you say "platform considerations," what exactly do you mean? I would absolutely love to test this out on my CR-48 because it looks pretty exciting. However, if CR-48 testers aren't even going to get this update, then why bother even having this beta device anymore?
Further explanation would be wonderful at this point. Will we will get this Version 20? Or what?
- This comment has been removed by the author.
My Acer chromebook wouldn't update for about a month, but for whatever reason I was able to get the Aura update. It is definitely awesome, hopefully you CR-48ers get it asap.
I would also like to see CR-48 support added to this release. It will be good for us to try out and send feedback.
- This comment has been removed by the author.
Thank you for this release: The UI looks great and the chromebook runs faster and smoother than in the previous developement release.
uname=Linux localhost 3.2.7 #1 SMP Fri Apr 6 08:17:13 PDT 2012 x86_64 Intel(R) Atom(TM) CPU N570 @ 1.66GHz GenuineIntel GNU/Linux
Does this mean cr-48 will never get aura even when its updated to version 20?
@footstep: Thanks! (it's indeed 64-bit, so I'll wait a few days before breaking my system ^^)
- This comment has been removed by the author.
Can we please get a yes or no on the cr-48 getting aura?
With the way the answer was originally answered... it seems like it never will and the cr-48 will be getting minor security updates but nothing past what is currently on the device.
If so... that really sucks. I love this laptop and would hate to see google throw it aside already.
We plan to bring Aura to Cr48 with Chrome 20, perhaps with a more limited feature set.
The Cr48 device does not have the graphics horsepower to deliver the full Aura experience, and we decided it was more important to focus on a high-quality full experience for Samsung and Acer.
The alternatives would have been either delaying the Aura release for everyone or delivering something that doesn't work well and crashes a lot on Cr48.
For Chrome 20, I hope we can deliver Aura for Cr48. We'll try it in the dev channel soon and learn about how well it works.
We're not abandoning Cr48. We're trying to make something work for Chrome 20, but the Cr48 cannot support all of the beautiful Aura features. We'll start testing Chrome 20 on Cr48 with the next Dev channel update, which should come out within a week.
My Series 5 is still on version 15 of the beta channel. I am trying to switch over to the dev channel and have selected more info and have chosen it from the drop down but it continuously states that it is up to date
The development channel is where ideas get tested, but can be very unstable at times. Please proceed with caution.
1011.43 (Official Build) beta-channel x86-alex
Any ideas are greatly appreciated.
Christopher: Your series 5 should be on version 18+ by now. If you go to about:chrome and "Check for update" and can't get anything newer please file an issue at crosbug.com
Im glad to hear the cr48 will see at least a test of aura. I love this laptop. I know it doesn't have all the bells and whistles.. but its a great machine for what it needs to do.
Thanks for clarifying. I look forward to seeing how well this little guy can keep up.
Keep up the good work.
All i want is the "Other Devices" feature. Will at least that feature make it to the Beta or Stable version?
Im starting to have more and more sites crash. It may be unrelated but I want to try switching back to 18. Is there any problem in reverting.
I am having the same problem... all of a sudden this release is crashing every ten minutes or so.

subset: commoncrawl


text:
LG GD900 Crystal Video clips
More Videos
The LG Crytal utilizes the slider form-factor, which contributes to its stylish nature. When the phone gets opened, it attracts everyone's attention, since a light illuminates the transparent keyboard. Other features include a 3" WVGA multi-touch display, 8MP camera, Wi-Fi, stereo Bluetooth and microSDHC card slot.


text:
|Wading River, N.Y.
|High School:
|Shoreham-Wading River
|House Affiliation:
Career Highs
Goals: 2 (several times)
Assists: 2 (Boston College, 4/17/13)
Points: 3 (three times, most recent Boston College, 4/17/13)
Ground Balls: 5 (Columbia, 4/21/12)
Draw Controls: 3 (two times, most recent Holy Cross, 4/10/13)
Caused turnovers: 1 (several times)
Junior · 2013
Played in 13 games ... Had two draw controls and a ground ball against Penn (March 9) ... Assisted on a goal and and had a ground ball at Marquette (March 19) ... Handed out an assist at Vanderbilt (April 1) ... Dished out an assist and had two draw controls at Brown (April 6) ... Tallied a goal and had a career-high three draw controls at Holy Cross (April 10) ... Netted a goal, handed out a career-high two assists and added a draw control at Boston College (April 17) ... Assisted on a goal and grabbed a ground ball at Dartmouth (April 26) ... Tallied two goals in win over Columbia (April 28).
Sophomore · 2012
Had one assist and one ground ball in double-overtime victory against James Madison ... Grabbed one ground ball versus Boston College ... Scored one goal in win against Stanford ... Scored one goal versus Syracuse ... Had an assist against Virginia ... Tallied one goal and one assist in win versus Brown ... Tied her career high with three points (2g, 1a) and grabbed one ground ball in win against Holy Cross ... Scored two goals, picked up a career-high five ground balls and caused one turnover in win over Columbia ... Scored one goal against Penn in the Ivy League Semifinals.
Freshman · 2011
Started in all 16 games … Sixth on the team in goals (10) and points (13) and fourth in assists (3) … Won eight draws, collected 17 ground balls and caused two turnovers this season… Scored two goals and had an assist in win over Yale … Also had two goals in Harvard's upset of No. 10 Dartmouth in the Ivy League tournament.
Before Harvard
Three-year letterwinner in lacrosse at Shoreham Wading and two-year letter-winner at Guilderland High School … Played three seasons of soccer … Captained lacrosse team as a senior … Academic All-American … Honorable mention All-American as a senior … Earned second-team All-Suffolk County as a sophomore and first-team as a junior … Member of the 2007 and 2008 Adirondack Empire State Lacrosse team … Member of the 2009 Under Armour Underclassmen New York Team and the National Tournament New York Team 1 … As an eighth grader helped Shoreham Wading River to New York state semifinals … Helped Guilderland to state quarterfinals as a freshman and semifinals as a sophomore … Won state Class C championship for Shoreham Wading as a junior and senior … Selected by U.S. Lacrosse to play in the 2010 Champion High School Showcase televised on ESPN …Member of the National Honor Society.


text:
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text:
Lords of Middleton is a member of the Guild of Q Butchers, which means that you, the customer, can be confident that the meat you buy from us is properly stored, displayed and handled prior to purchase.
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1st Graders to Azalea Estates
- Azalea Estates 1318 Andre St New Iberia, LA, 70563 United States (map)
Epiphany Day School is a co-educational independent school founded by Episcopalians for Pre-Kindergarten through Fifth Grade. We provide a challenging academic program enhanced by arts integration and experiential learning. We value scholarship, honor, and service.
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This Volume deals with Psychological and Social Problems
The overall series discuss issues relevant to Islam, and present
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February 05, 2019
Kendall Jenner Got Bangs and She Looks Like a Completely Different Person
Please gather round, because
Kendall Jenner
just got a makeover that would make Cher from Clueless truly shook. Which is my prolonged way of saying that she got bangs.
Kendall uploaded a photo of her new look to Instagram with the caption "yes, no, maybe so" and I'm going to go ahead and answer with a hard YES.
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Snow hits the UK; Manchester Airport closed, flights canceled
Filmmaker Sir Peter Jackson announces new documentary on the Beatles
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Kendall Jenner and Bella Hadid facing possible subpoenas over Fyre Festival
'Black Panther' returning to theaters for free Black History Month screenings
Brexit: May to ask EU to reopen withdrawal agreement over Irish backstop
Former Labour MP Fiona Onasanya jailed in speeding case
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Let Me Finish review: Everybody hates Chris Christie – and he hates Jared Kushner
Jeff Flake rules out 2020 primary challenge to Trump
Trump accepts invitation from Pelosi to deliver State of the Union on Feb. 5
John Krasinski Causes Meltdown on Twitter As He Tears Up During Wife Emily Blunt's SAG Speech
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Apple rushes to fix FaceTime bug that let users eavesdrop on others
Toy Story 4: NEW teaser gives first look at THIS major original character's return
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|Image from here
I am a breakfast eater and have been most of my life. It is the one meal that I don't seek variety and samey-samey is absolutely fine for me. I don't think my brain is too discerning in the morning. During the week you will find me eating a bowl of muesli but I welcome a fry-up or some pancakes at one day of the weekend (especially when prepared by someone else).
The Geege struggles with breakfast but manages to stomach something most mornings. Often just a banana and a coffee, or three.
Dew Drop would eat breakfast foods at every meal if he could. He is the Hobbit of the family who frequently has second breakfasts. He likes all types of cereals, fruit and yoghurt and toast.
The Minx is hit and miss, one day to the next, with no rhyme or reason. Yesterday she ate a bowl of weetbix with sultanas, today she had two mouthfuls and declared she hated it. We take it one day at a time with our precious.
Doo Dah likes variety with his breakfasts but will happily eat something on most days. He makes requests on different days for cereal, toast, eggs, pancakes or a smoothie. We usually give him what he asks for.
Nugget, well he is the fussy fuss pot of the family and breakfast is no exception. He will eat toast, but he would live on bread alone if we would let him. He also likes Nutrigrain, but I only let him have it on holidays.
Needless to say, I am always on the look out for quick and healthy breakfast ideas (that are not cereal) that will meet the needs of all the family. I am accruing a lovely list of options we have been trying out and I want to share with you:
- Muesli muffins (Nugget still won't eat these, but the other kids love them)
- Tomato on wholegrain toast, even better with a bit of cottage cheese spread on there too
- French toast
- Egg soldiers
- Fruit smoothies
- Wholewheat banana bread
- Baked beans on toast
- Fruit salad and yoghurt
- Ham and egg cups - Put a slice of ham into a muffin tray and top it with an egg. Bake until firm. Eat hot or cold.
- Porridge (no success with any of the kids liking oats, but I love it!)


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You Can't Ignore Me Any Longer
Working anonymously, pasting his giant images on buildings, trains, bridges, the often-guerrilla artist JR forces us to see each other. Traveling to distant, often dangerous places—the slums of Kenya, the favelas of Brazil—he infiltrates communities, befriending inhabitants and recruiting them as models and collaborators. He gets in his subjects' faces with a 28mm wide-angle lens, resulting in portraits that are unguarded, funny, soulful, real, that capture the spirits of individuals who normally go unseen. The blown-up images pasted on urban surfaces—the sides of buildings, bridges, trains, buses, on rooftops—confront and engage audiences where they least expect it. Images of Parisian thugs are pasted up in bourgeois neighborhoods; photos of Israelis and Palestinians are posted together on both sides of the walls that separate them.
JR's most recent project, "Women Are Heroes," depicts women "dealing with the effects of war, poverty, violence, and oppression" from Rio de Janeiro, Phnom Penh, Delhi and several African cities. And his TED Prize wish opens an even wider lens on the world—asking us all to turn the world inside out.
"I would like to bring art to improbable places, create projects so huge with the community that they are forced to ask themselves questions." -JR, Beaux Arts Magazine
- LEARN: insideoutproject.net
- READ: Join the discussion on TED here.


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I think:
'Its' is a determiner. It means belonging to or connected with a thing, an animal or a baby
For example,
Turn the box on its side.
The dog had hurt its paw.
The baby threw its food on the floor.
'It's' is a short form. It may either be it is or it has.
Student or Learner


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Purdue looking to make a statement against Michigan
WEST LAFAYETTE, Ind. (AP) -- Purdue believes it has the pieces to make a Big Ten title run this season.
The defensive line is big and deep. The secondary is quick and experienced. At quarterback, the Boilermakers have three players with starting experience, and receivers and running backs with enough overall speed to challenge opponents.
The only thing they've been lacking is a national reputation.
Purdue (3-1) can change that Saturday against Michigan (2-2).
"We've been thinking about this since the beginning of the season," defensive tackle Kawann Short said. "We feel, right now, we're in a better position. We did what we had to do (in the non-conference season), we just need to live up to the hype."
So far, those large expectations have been relegated almost exclusively within the program.
Beating the Wolverines could change everything.
The Boilermakers are uniquely positioned to chase the Leaders Division crown thanks to their first 3-1 start since 2007, the fact that perennial powerhouses Ohio State and Penn State are ineligible to win the division title and each of the three other division foes -- Wisconsin, Indiana and Illinois -- have already lost conference games.
Should the Boilers survive Saturday and the next two weeks -- at home against the Badgers (3-2) and at No. 12 Ohio State (5-0) -- Purdue would suddenly and surprisingly have the inside track to play a Big Ten title game barely an hour away from its campus.
Purdue's players and coaches never doubted they could get here, and now the outsiders are beginning converts.
"We thought a year ago they were a good football team. I think the week before they played us, they beat Illinois and really got after 'em pretty good," Michigan coach Brady Hoke said. "So from a skill standpoint and up front defensively, they've got some playmakers."
The Wolverines had big plans this year, too, but like the rest of the Big Ten, have struggled.
Michigan started the season ranked No. 8 before getting thumped by No. 1 Alabama, needed a late field goal to close out a victory over Air Force and after a rout of Massachusetts, committed five first-half turnovers in a 13-6 loss at Notre Dame.
The second loss knocked the Wolverines out of the rankings and sent them into a bye week with plenty to ponder.
Denard Robinson, who has rushed for 441 yards and four scores in the first four games, used the extra week to contemplate what he's doing wrong after throwing two interceptions per game this season and at least one pick in 11 of his last 12 starts.
"I felt like I let my teammates down," Robinson said, referring to his sub-par performance against the Fighting Irish. "I had to be accountable to the team, and that's not throwing interceptions, that's playing my role on the football team and knowing it's OK to throw the ball away, knowing it's OK to take a sack sometimes, knowing it's a good play to punt sometimes, knowing it's a good play if I have to run the ball. I got to start making better decisions as a quarterback."
While Robinson spent last week's bye trying to correct his own mistakes, Hoke prodded his team to go back to the basics. And with an extra week to prepare for Purdue, Hoke may have some new looks Saturday.
"They'll have time to look at what we do and come up with some new wrinkles to try to exploit some of the tendencies that we may have and some of the plays that we call throughout the course of the season," Hope said.
But the real test for Robinson & Co. comes Saturday against a Purdue defense that already has 11 sacks, leads the Big Ten with eight interceptions and had two interception returns for scores last week. Short, a 315-pound defensive tackle, may be the best interior linemen in the Big Ten.
Michigan's defense faces a stiff challenge, too, against an offense that is just starting to get in sync and play like a contender.
"I think (Caleb) TerBush is better," Hoke said, describing Purdue's starting quarterback. "I think this guy has come in and been very -- percentage pass-wise done a good job with the football."
Which puts the Boilermakers in perfect position to achieve one of their biggest goals this season: Putting the Cradle of Quarterbacks back on the national college football map.
"A win this Saturday would be huge for our football team, and I think it would be an excellent step in the right direction in our pursuit of returning our football program to national prominence," Hope said. "Michigan won 11 games last year and they're an excellent football team. It's a great opportunity, but we've positioned ourselves to be in this position."


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A holiday extravaganza!
Interviews with:
Ronnie Spector, the very bubbly and Christmas-spirit filled lead singer of legendary 60s girl group The Ronettes, performed what became Christmas classics on A Christmas Gift for You, and she's recorded some new songs to add to the list with Ronnie Spector's Best Christmas Ever. (Transcript)
Fred Schneider is best known as the frontman of the new wave group The B-52s. Hear some of his signature talk-singing and tracks from his band The Superions' Destination… Christmas! (Transcript)
And finally, a visit from Tasha Robinson and Kyle Ryan of The AV Club for a holiday gift guide including Bruce Springsteen's The Promise box set, The Goonies, Simpsons World: The Ultimate Episode Guide, and The Secret of Kells. (Transcript)
Plus some of our favorite holiday music. It's all in one big, fun, festive show, and we hope you enjoy it. Happy Holidays!


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Last time he competed in a US Grand Prix, Narain Karthikeyan chalked up a Formula One first while a jeering Indianapolis crowd threw bottles and demanded their money back.
Even if that infamous 2005 six-car race made him the first Indian F1 driver to score points, the 35-year-old would much rather focus on the future as he prepares for next week's return to America for the inaugural grand prix at the new Austin circuit in Texas.
"I have no feeling about it," Karthikeyan, now with Spanish-based back-markers HRT, told Reuters when reminded of that farcical June afternoon of seven years ago. "I have nothing much to say really.
"I don't think about it like that," he added when asked whether the race held any special place in his affections for at least allowing him to make history for his country by finishing fourth. "It was exceptional circumstances and we were told to do a job and we did it.
"Everyone started the race... we didn't know before the race. It was pretty weird to see all of them going out with the warmup lap and back to the pits. Bridgestone had told us to race and we did," he recalled.
The Indian was one of just six drivers who started the race, won comfortably by seven-times champion Michael Schumacher in a Ferrari, after all of the teams using Michelin tyres pulled out for safety reasons.
The six Bridgestone-shod cars lapped in team formation for 73 laps before the chequered flag and the crowd was outraged on an afternoon that created a wave of negative publicity for a sport that had long sought to win over America.
Karthikeyan, who raced for the now-defunct Jordan team in 2005, left Formula One at the end of that season to become the Williams test driver.
The veteran did not return to the grid until 2011, by which time America was off the calendar. He has not come close to scoring a point since 2005.
The first Indian driver to race in Formula One, Karthikeyan's record as the most successful from his country could last for decades to come but he knows it does not stand up to any real scrutiny.
"It was what it was. Maybe it wasn't good to happen in the States... but it's too far in the past now," he said of Indianapolis. Formula One has not raced in the United States since 2007 and Austin, a vibrant city with a young student population, represents a new start with what is expected to be a very different atmosphere to the past.
Karthikeyan has raced in America outside of Formula One, competing in the NASCAR truck series in 2010 and being voted by fans as the most popular driver, but a non-F1 return is not in his plans even if he loved the experience.
"I doubt it very much. Once you get out of there it's very difficult to go back," said the man whose website proclaims him to be the "Fastest Indian in the world", having already shot down speculation that he was planning a move to IndyCars.
"These Indy Car rumours came about and I've strongly said no and that's my decision," said the Indian, whose place at HRT is not a given for 2013, despite the sponsorship he brings in. "I have very clear plans what I want to do next year and I will focus on that and try and achieve them. I would love to stay here and see how it shapes out next year... realistically this would be a good place to stay."


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IT Expertise by Allegro's President
Magento Go shut down to allow focus on core development
Magento, the world leading open source e-Commerce solution, has made the difficult decision to shut down their Magento Go offerings. This is to allow them to focus their efforts and resources on developing their core Magento product and get away from offering a hosting solution. They are no longer accepting new accounts and will be shutting the service down altogether on February 1, 2015.
As a business owner, I can understand the difficulty in making such a tough decision but I applaud them for focusing back on what they do best. We here at Allegro have had great success in using their products for our own clients, implementing in such diverse areas as furniture sales, organic health food products, plumbing supplies and direct B2B interactions.
I am looking forward to seeing the results of this new focus in the coming year. You can read more about Magento Go and their plans on their site.


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As we Americans confront our latest episode of innocent civilians being slaughtered by some nut-job with legal guns, a few folks have wondered aloud again about whether there's a way to reduce these episodes.
One of the ideas, not surprisingly, is to have tighter gun-control laws.
As ever, this idea has been met with a barrage of Second Amendment-related bullets, many of which boil down to the idea that we need guns to "protect ourselves" from people like the Colorado shooter.
In theory, this sounds like a compelling point. But despite the fact that guns are freely available everywhere in America, no one ever seems to have one handy when some psycho opens fire. Or the guy with "protection" fires back, misses the shooter, and hits other innocent people instead. Or the guns end up killing the kids and spouses of the people who bought them for "protection." Or something. Anything but the "protection" they're supposed to offer.
Another anti-gun-law argument that pops up occasionally is that we need the guns to protect ourselves from the government.
That might have been a reasonable argument back in 1791, when the government had a few muskets and Americans had a few muskets, so it was a fair fight. But any Americans who think that having a semi-automatic weapon around the house these days is going to "protect" them from the combined might of the Army, Navy, Air Force, and Marines have bigger things to worry about than the availability of guns. (Like their sanity.)
In any event...
It's worth noting that there's one country that does have extremely tight gun-control laws.
And that country is not known for episodes of mass-slaughter of civilians at the hands of some wacko.
And it's really not known for gun-related deaths.
Because there pretty much aren't any.
That country is Japan.
Guns are really, really hard to get in Japan.
As a result, not many people are killed with guns in Japan.
In 2008, Max Fisher of the Atlantic reports, about 12,000 Americans were killed with guns.
How many do you think were killed in Japan that year?
(Yes, that's 11. Not 11,000. 11.)
And as Fisher points out, 11 gun deaths made 2008 a bad gun-death year in Japan. In 2006, 2 people were killed with guns.
Fisher also explains what you have to do to get a gun in Japan:
Japanese tourists who fire off a few rounds at the Royal Hawaiian Shooting Club would be breaking three separate laws back in Japan -- one for holding a handgun, one for possessing unlicensed bullets, and another violation for firing them -- the first of which alone is punishable by one to ten years in jail. Handguns are forbidden absolutely. Small-caliber rifles have been illegal to buy, sell, or transfer since 1971. Anyone who owned a rifle before then is allowed to keep it, but their heirs are required to turn it over to the police once the owner dies.
The only guns that Japanese citizens can legally buy and use are shotguns and air rifles, and it's not easy to do. The process is detailed in David Kopel's landmark study on Japanese gun control, published in the 1993 Asia Pacific Law Review, still cited as current. (Kopel, no left-wing loony, is a member of the National Rifle Association and once wrote in National Review that looser gun control laws could have stopped Adolf Hitler.)
To get a gun in Japan, first, you have to attend an all-day class and pass a written test, which are held only once per month. You also must take and pass a shooting range class. Then, head over to a hospital for a mental test and drug test (Japan is unusual in that potential gun owners must affirmatively prove their mental fitness), which you'll file with the police. Finally, pass a rigorous background check for any criminal record or association with criminal or extremist groups, and you will be the proud new owner of your shotgun or air rifle. Just don't forget to provide police with documentation on the specific location of the gun in your home, as well as the ammo, both of which must be locked and stored separately. And remember to have the police inspect the gun once per year and to re-take the class and exam every three years.
Even the most basic framework of Japan's approach to gun ownership is almost the polar opposite of America's. U.S. gun law begins with the second amendment's affirmation of the "right of the people to keep and bear arms" and narrows it down from there. Japanese law, however, starts with the 1958 act stating that "No person shall possess a firearm or firearms or a sword or swords," later adding a few exceptions. In other words, American law is designed to enshrine access to guns, while Japan starts with the premise of forbidding it.
Gun control is a complex subject in America, especially with such wide-ranging population-densities, cultures, and so forth. And I certainly don't think there's one "right" answer to how we can reduce the armed-psycho-blows-away-innocent-people problem.
But judging from Japan, maybe tighter gun-control laws would help, at least a bit.
SEE ALSO: Can We At Least Agree On This One Thing About "The Right To Bear Arms"?


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pur3 0wn1ng9 wrote:Why was mine disqualified? I made sure I entered the right pick, put a tag, and entered it in the pool but I am still disqualified!?!?
This really sucks!
THE RULES wrote:...tagged with "FBTB" and "2009 Podracer Challenge", and submitted to the FBTB group to qualify. It's important to use the quotes when adding the tags or it will split them up.


text:
At 1:44, we received an email saying Mike D'Antoni was stepping down as Knicks coach. It supposedly came "straight from the D'Antoni family," but we hadn't dealt with the source before, couldn't confirm, and wasn't particularly the kind of thing that's worth getting wrong.
A half-hour later, Adrian Wojnarowski broke the news that D'Antoni did indeed resign, citing "conflicting visions of the club's future." Carmelodrama is very real and very destructive.
Assistant coach Mike Woodson will take over the rudderless Knicks in the interim. As for D'Antoni? Our tipster, currently batting 1.000, says that "he has either the Wash or Charlotte job lined up, otherwise he would not have left." For what it's worth.


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Code Hero is a game that teaches you how to make games so you can learn to code while you play with a Code Gun that shoots Javascript in Unity 3D!
Now's our chance to accelerate our momentum to reach $200K so we can add multiplayer! Let's front page Reddit today!
Just hours left to make indie history with games that teach people how to make games. Here's the announcement video of what happens next (Don't miss the party invite!):
Code Hero Hero's Kickstarter Victory party will be tomorrow Thursday night at 7PM in San Francisco. Pledge to receive directions as it is a private party and all backers can check the latest update to find information about the party!
The Code Hero Army has outdone itself already and the next 39 hours will be our finest: Let us make indie crowd funding history together so that we can build the ultimate Code Hero!
If we raise $200K, we can add Multiplayer!
Code Hero's ultimate and most challenging feature to create is multiplayer. For this to be achievable, this Kickstarter cannot rest till the countdown strikes zero! Spreading the word to new backers and telling your backer friends you're upping your pledge level if you want awesomer rewards are both good ways to encourage growth!
Read the UPDATES! We're on ALL the news!
Join volunteer Code Hero Army to spread it!
For international order please include $10 for shipping
Code Hero Trailer 2: Operation FizzBoss
Everyone Who Pledges Gets the Game Beta
When you pledge, you get immediate access to create your account and download the Code Hero game beta. You can try it today and tell your friends to pledge to get their accounts and help fund the development of the full game. Start playing and learning. You'll get the latest versions each time they are released with improvements that your pledge helps fund!
This is your code gun! Shoot code to execute it on the target on impact. Copy, tweak and write code to alter the 3D world from the inside out.
To move a platform down, shoot hitObject.transform.position.y-=2;
Enter the World of Code as a Primer Labs Game Tester and enroll in the mysterious Gamebridge Unityversity to learn enough to challenge FizzBoss!
Master the secrets of Codefoo to defeat the devious coding challenges of the FizzBosses
FizzBoss is the first test of your code knowledge combining the Javascript and Unity game programming that you learn.
ShipBoss ultimately challenges you to make a game of your own to earn a place as a Shipped Officer on the Real Artists Ship!
JobBoss tests your ability to do advanced challenges that could get you job interviews with top game companies!
Master the Unity3D game engine from the inside out to make games of your own and master the full stack to become the next code hero!
What you learn to make with Unity
The Unity game engine that Code Hero teaches you how to code in is the ultimate indie game development powerhouse. You can use Javascript, C#, and Python-like Boo to write games that run on everything: Mac, Windows, iOS, Android, XBox 360, Playstation 3, Wii, Web player, Flash, Native Client... You can put what you make into the App Stores and have your creations for sale to start your own indie game company! Master the Unity3D game engine from the inside out to make games of your own and become the next code hero!
Who We Are
I'm Alex Peake the founder of Primer Labs and I've spent the last year building Code Hero as an indie game with the Primer Labs team so you could play it. I've taken it as far as I can on my own and I need your help to make Code Hero the game that can turn you into a game programmer. i have some of the most talented people in the world ready to work on this to take it way beyond what I could do by myself.
What we need funding to do
Most games cost millions of dollars to make. Code Hero is more ambitious than most games. Code Hero is carefully designed to be achievable for much less money by having 4 programmers and 2 artists work for six months to predict a carefully planned new kind of game that is made possible by the quality of these people, the brilliance of the Unity game engine and the release of each version so you can help us improve it continuously.
The New Artist
Code Hero's new led artist is Gizmo of Farbrausch demo crew and Gamebrausch Studios, a legend amongst creatives who has produced tech that was often 5 years ahead of the commercial game industry such as Kkrieger, a Doom 3-level engine and game in 95K.
The Coder Challenge: Kickstart Your Game Making!
Make your own game and make something awesome to submit to kickstarter yourself! We'll send a Primer Labs lab coat to everyone who posts their game on Kickstarter!
The 1 K12 Code Hero School Challenge
Give your children more than a game: Give their whole school programming peers that will engage and inspire each other. A parent, teacher, student, administrator or entrepreneurial youth can pledge to give a school of their choosing a special school-wide Code Hero access. All their students will receive school accounts for Code Hero.
Teachers will be trained by the Code Hero team to be able to mentor students who can mentor each other. Code Hero School will feature advanced metrics and collaborative gameplay that will allow teachers to integrate it into making projects for every subject and class in the school. Art classes can produce game art for history projects that become simulated historical worlds with math class showing how engineering created disruptive new industries that economics class analyzes for modern parallels [HINT HINT].
Check out Hack The Future and Unityversity to see how we teach large groups of kids already to make and present games on their first day.
PETITIONERS WELCOME. You can pledge at this level to petition your school to try it: Call them, ask them if they will accept it on behalf of all their students. This doesn't require a school approval process or a strategy session: It just opens the door for a new kind of education through games that kids actually want and enjoy!
UNCONDITIONAL GIVING: If you can't get a school to accept, you can give it directly to the students of the school to form a Code Club to provide the power of one good example: a school where every student can code fluently and create games as group projects as easily as presentation poster boards and science fair exhibits.
Every state needs at least one representative that will take up the Code Year challenge to show there is no state that is not ready to become an economic powerhouse, that there is no district that can't emulate Silicon Valley, and that there is no school that can't become a flourishing entrepreneurial hotbed of student-created startups!
Testers Trying Code Hero
Here are two of our first testers to try the beta in their own words. They had played just a cakeslice of what we were buiding, but they made us realize immediately that Code Hero makes sense to people who have played Portal and Minecraft, two of our favorite games. We think in the future, every school will buy an educational bundle through Steam for Education with a Minecraft for Schools / Portal Science / Code Hero package. We'd love to talk to Mojang and other edutech games about collaborating in schools!
Steampunk Computing: Babbage & Lovelace
One of the worst investment decisions in human history was cutting funding to the inventors of computers, Charles Babbage and Ada Lovelace. Computers turned out to be a pretty keen idea after all, yet less than 1% of humans can code.
Code Hero includes steampunk missions where you help Ada and Charles Babbage construct a 3D replica of the Difference Engine whose replica is actually built and working in its entirety at the Computer Histroy Museum.
Giving everyone the gift of code literacy is the first step towards investing in our creativity and setting ourselves free to invent the future!
Alex at Humanity+ @Caltech:
As we make game AIs to be our machine mentors teaching us to make better game AIs, what happens when we make machines that make us make them make us into them?
Thank you for your support!
You can find more details about Code Hero on our site:
UPDATE 1: Congratulations to Tim Schafer!
UPDATE 2: Pledgers click here to download Mac & Windows game beta
UPDATE 3: Read about what we plan to make with your help: Multiplayer sandbox creativity, comptitive Codefoo and more!
UPDATE 4: IT'S OVER $16000! Thanks to all tweeting and blogging the surge.
UPDATE 6: We just got BoingBoinged!
UPDATE 5: The BoingBoing is on Reddit! Vote it up!UPDATE 7: David Helgason the CEO of the Unity game engine Code Hero teaches you to make games with donated $1337 and is spreading the word!
DEVELOP MAGAZINE: Unity CEO Backs Kickstarter for Gamified Dev Tool Code Hero,
TechCrunch: Kickstarter indie game is disruptive in code learning startup space
for ( days = 7; days > 0; days -- ) {
Smashes( dollars * days * days * viral );
(NOTE: You get to PLAY the beta now by pledging & make it a success!
If it isn't funded you get refunded so there's no reason not to pledge!)
Funding period
- (60 days)


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Damon can relate to Ellsbury's route to Yanks
BOSTON -- A World Series-winning leadoff man and center fielder going from the Red Sox to the Yankees?
That appears to be the direction Jacoby Ellsbury is going in, according to multiple reports that surfaced Tuesday night. And there's one person who can relate to the situation better than anyone else.
BOSTON -- A World Series-winning leadoff man and center fielder going from the Red Sox to the Yankees?
That appears to be the direction Jacoby Ellsbury is going in, according to multiple reports that surfaced Tuesday night. And there's one person who can relate to the situation better than anyone else.
"The good thing is Jacoby brought two World Series championships to Boston, and he's a heck of a player," said Johnny Damon in a phone interview with MLB.com. "It just seems like he's finding a way to stay healthy, and he's going to be awesome for New York. Unfortunately for Boston fans, this is kind of what happens sometimes."
Ellsbury's deal with the Yankees, which is pending a physical, is a stunning $153 million over seven years, MLB.com has reported. It comes just a month after Ellsbury won his second World Series with the Red Sox, this time in six games against the St. Louis Cardinals.
It was eight years ago that Damon, a poster child for the 2004 "Idiots" that snapped an 86-year-old championship drought, took a four-year, $52 million deal and fled the Sox for the Yanks.
"As much as your heart belonged to Boston and everything, it comes down to being a business," Damon said. "Unfortunately, we're part of that. I wish him the best and, yeah, it's pretty crazy."
In Damon's case, following the 2005 season, the Red Sox were at least willing to match the four-year offer, but they offered $12 million less in the total value of the deal.
The Red Sox were all but certain to avoid giving the 30-year-old Ellsbury a seven-year contract. Boston felt it was a mistake signing Carl Crawford for seven years and $142 million three years ago.
In fact, general manager Ben Cherington was grateful when the Dodgers took not only that contract, but also Adrian Gonzalez's long-term pact off the Red Sox's hands in a blockbuster trade on Aug. 25, 2012.
Ellsbury, assuming the deal goes through, will join a long list of star players who played with the Yankees after having success with the Red Sox. Babe Ruth, Wade Boggs, Roger Clemens and Damon are among those who tested those waters. And all of them tasted World Series glory in the Bronx.
That type of history could leave Red Sox fans feeling ornery when Ellsbury and the Yanks make their first visit to Fenway Park on April 22.
Damon, who was 32 when he left the Red Sox, certainly remembers the boos he got on May 1, 2006, in his first trip back to Fenway. He hopes the fact that the Sox are fresh off a World Series this time, compared to a year removed in his case, will make the atmosphere lighter for Ellsbury.
"I think it depends on what people make of it," Damon said. "Jacoby just helped the team win another World Series. They're going to be grateful for that. But the Boston fans are notoriously hateful to Yankee players. The way that Jacoby plays, he's still going to have the respect throughout the league. The fact is, he hustled and that's what Boston wanted -- somebody who cares about the game and somebody who would run into walls and who would take accountability, and that's the guy.
"Yeah, it's going to be tough at times, but he's a good enough player that the fans are still going to respect what he gave to Boston and what he's going to give to New York."
What Ellsbury should give more of to the Yankees is power. The new Yankee Stadium is heaven for left-handed hitters with power to right-center. Fenway, on the other hand, is 380 feet to straightaway right.
In four seasons with New York, Damon hit 77 homers. In his four years with Boston, he hit 56.
"Oh, I think it's going to play great for his swing," said Damon, who last played in the Majors in 2012. "He has power and still has a lot of good years left in him. And the thing is, New York needed to do it. They weren't looked at as one of the elite teams. With that signing, it puts them right back into the race again."
It remains to be seen what the Red Sox will do to offset the departure of Ellsbury. They could go with prospect Jackie Bradley Jr., but the jury is still out on whether he is ready offensively.
Another option would be to move Shane Victorino back to his natural position of center field and trade for or sign a corner outfielder. Carlos Beltran is the most prominent corner outfielder on the free-agent market.
As for the culture shock Ellsbury might feel when he goes from Boston to New York, Damon was actually surprised by what the transition was like for him.
"I actually thought going to New York was easier to deal with, just because there's so much going on," said Damon. "Baseball isn't the New Yorkers' everything. They've got so many sports teams to follow, they've got Broadway, they've got actors and actresses, Wall Street, all that stuff. Everybody can kind of do their thing."
It is somehow fitting that Ellsbury appears to be following a similar route as Damon.
When the Red Sox drafted Ellsbury in 2005, he was immediately compared to Damon, the man who was in his final season in Boston that year.
"I feel like I was part of the Jacoby Ellsbury business," Damon said. "If they re-signed me, maybe they would have traded Jacoby. Or Jacoby may not have gotten that shot in Boston. Things work out for a reason. Unfortunately, some fans don't see it that way. Jacoby has always been compared to me, in a way, since he was signed. So this is just another comparison. And hopefully, he enjoys both places as much as I have."
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne.


text:
Company to Focus on Manufacturing Customer Base
FITCHBURG, MA--(Marketwire - Nov 21, 2012) - Arrhythmia Research Technology, Inc. (the "Company") (
For the nine months ended September 30, 2012, total revenue was $15,881,000 and net loss was $4,885,000 as compared to total revenue of $18,929,000 and net loss of $301,000 for the same period in 2011. Net loss per share for the nine months ended September 30, 2012 was $1.75 as compared to loss per share of $0.11 for the same period in 2011.
Michael Gunter, the Company's Interim CEO, commented "The shortfall in revenue in the quarter was primarily attributable to lower silver surcharge billed and lower customer orders in sensors and defense compared to the same period in the prior year. European sales were down in large part due to a customer being acquired and lower orders taking place in the third quarter as the companies integrated operations and inventories. We are seeing orders increase in the fourth quarter and expect orders from this customer to return to historical levels in 2013.
During the third quarter, the Company decided to shut down the operations of the WirelessDx subsidiaries. We have currently ended all operations of WirelessDx and are on track to complete the liquidation of its assets by year end. Expenses and charges related to this shutdown and liquidation of assets are estimated to be $2,350,000. Additionally, as a result of impairment testing conducted during the quarter, the Company recorded an estimated preliminary impairment charge to Goodwill related to continuing operations of $1,479,727. These items negatively impacted results for the quarter.
Management intends to refocus on the vertically integrated diversified manufacturing capabilities of the Company and on growth opportunities with new and existing customers, and returning to profitability in 2013."
About Arrhythmia Research Technology, Inc.
The Company manufactures injection molded, machined and plated metal and plastic products to the medical, automotive and defense sectors. In addition to manufacturing the company provides value added end-to-end product life cycle management, design, engineering, prototyping, manufacturing, machining, assembly and packaging services to its customers. The Company's products also include a customizable proprietary signal-averaging electrocardiography (SAECG) software used in the detection of potentially lethal heart arrhythmias and that is reconfigurable for a variety of hardware platforms.
For more information please check our websites:
Forward-looking statements made herein are based on current expectations of the Company that involve a number of risks and uncertainties and should not be considered as guarantees of future performance. The factors that could cause actual results to differ materially include: our ability to maintain our current pricing model and/or decrease our cost of sales; our ability to increase sales of higher margin products and services; variations in the mix of products and services sold; variability of customer delivery requirements; a stable interest rate market and/or a stable currency rate environment in the world, and specifically the countries where we are doing business; continued availability of supplies or materials used in manufacturing at competitive prices; volatility in commodity and energy prices and our ability to offset higher costs with price increases. More information about factors that potentially could affect the Company's financial results is included in the Company's filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K for the year ended December 31, 2011.
Contact Information:
David A. Garrison
Website: http://www.arthrt.com
(978) 602-1436


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Osteoarthritis (OA) is caused by aging joints, injury, and obesity. OA symptoms include joint pain and stiffness. Guys I wants to know that is there is a permanent solution for Osteoarthritis decease apart from surgery. Is yoga is beneficial for this??
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Yoga helps for ROM. To help the condition you need all inflammatory markers negative-easy to do, an anti -inflammatory diet,easy to do, and there are natural supplements which WORK!
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Train with peace of mind. Race with confidence.
Preparation is the key to successfully finishing any race. But, what if you never make it to the starting line? Event Registration Protection from Allianz Global Assistance can reimburse up to 100% of your nonrefundable registration fees if a covered illness or injury prevents you from competing, your car breaks down within 48 hours of the event, or one of the many other covered reasons ruins your plans.
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If life throws an unexpected wrench in your plans, Event Registration Protection can help you recoup the money you spent on your registration fees. For example, a covered illness or injury, delay or emergencies at home or work.
Benefits may vary. Look for event registration protector when registering for your next race, or call Allianz Global Assistance for more details about exact coverage: 1-877-794-3441


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Can you make a train the same length as Laura's but using three differently coloured rods? Is there only one way of doing it?
Can you find all the different ways of lining up these Cuisenaire rods?
Here are some rods that are different colours. How could I make a dark green rod using yellow and white rods?
How many trains can you make which are the same length as Matt's, using rods that are identical?
Find out what a "fault-free" rectangle is and try to make some of your own.
A thoughtful shepherd used bales of straw to protect the area around his lambs. Explore how you can arrange the bales.
A train building game for 2 players.
Use the Cuisenaire rods environment to investigate ratio. Can you find pairs of rods in the ratio 3:2? How about 9:6?
An environment which simulates working with Cuisenaire rods.
Train game for an adult and child. Who will be the first to make the train?
These squares have been made from Cuisenaire rods. Can you describe the pattern? What would the next square look like?
Using the picture of the fraction wall, can you find equivalent fractions?
Use the fraction wall to compare the size of these fractions - you'll be amazed how it helps!


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Wildflower seeds native to your region. Support local wildlife with native wildflowers.
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Step by step instructions on how to plant your fall-planted flower bulbs when they arrive.
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Learn about varieties which help to replenish nutrients to your soil.
Thrives in areas with cold freezing winters and hot summers.
Thrives in areas with hot temperatures.
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To determine if a plant is sufficiently cold hardy, the USDA created numbered zones indicating winter low
temperatures; the lower the zone number the colder the winter.
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'Provence' Lavender is a tall, aromatic variety with abundant slender blooms. Famed for its scent, 'Provence' is a favorite among soapmakers and dried flower arrangers. It's a prolific producer, sending up multiple flowers on its bushy plants that attract and support bees and butterflies. Heat-loving and drought-tolerant, 'Provence' has been known to withstand some bouts of humidity. Deer resistant.
Originating in the Mediterranean, lavender prefers hot sunny days, dry air, and non-enriched, well-drained soil. While that's great news for those gardening in the West, nowadays lavender can also be successfully grown in higher-humidity areas of the East and Pacific Northwest very successfully by remembering its basic needs. Be sure to pick a variety that is matched to your area. Depending upon your location and your desired use, there are lavenders for almost any setting. Next, follow the four basic elements to ensure lavender success:
1. SUN Lavender loves sun. Plant them in a sunny location where there is plenty of air circulation. Six to eight hours of sun is best, but some afternoon shade is fine in the hotter climates of the Southwest.
2. AIR Good air circulation is essential, especially in areas of high humidity. Lavender is not fond of damp, still air, which makes it prone to root rot. In humid areas, plant them with ample spacing, keeping in mind the mature size of your plant when in bloom and allowing for a bit extra space for good circulation.
3. SOIL Well-drained soil. This is perhaps the most important factor in success with lavender. One rule of thumb from is that the soil should be loose enough to dig with your hands, and not cake-like. You can add sand or small gravel to recreate this consistency if your soil is too compact. In areas where drainage may be a problem, mound the soil up to create a raised row or stand-alone mound.
In humid areas especially, a 1-2" mulch of pea sized gravel or white sand will do two things – it will help improve drainage, and it will reflect heat and light back up into the plant. More heat = more fragrant blooms! If you use a weed barrier, make sure it is breathable so the soil can drain and the roots can breathe. Gardeners struggling with growing lavender successfully in humid areas are encouraged to try planting Lavender Phenomenal.
4. WATER During the first year of your lavender's growth it needs to establish a good root system. It will require regular watering (unless you're experiencing healthy rain fall). Starting in the second year, your lavender will need less water, as it becomes the water-thrifty plant you're hoping for, but to get there it needs to grow deep roots in year one. By the end of year three it will have reached its mature size and shouldn't need any extra water. If water is needed, water in the morning, and deeply, to help root growth. A mature lavender plant is happy with only 9-12 inches of rain per year, but remember, with the right variety and good drainage lavender can thrive with more water.
Learn How to Grow Lavender in Detail.
As soon as your order is placed you will receive a confirmation email. You will receive a second email the day your order ships telling you how it has been sent. Some perennials are shipped as potted plants, some as perennial roots packed in peat. The 'Plant Information' section describes how that item will ship. All perennials and spring-planted bulbs are packaged to withstand shipping and are fully-guaranteed. Please open upon receipt and follow the instructions included.
Perennials and spring-planted bulbs are shipped at the proper planting time for your hardiness zone. Perennial and spring-planted bulb orders will arrive separately from seeds. If your order requires more than one shipment, there is no additional shipping charge. See our shipping information page for approximate ship dates and more detailed information. If you need express shipping or have any questions, please call Customer Service toll-free at (877) 309-7333 or contact us by email.
Our shipping rates are calculated based on our actual average shipping costs. We do not seek to profit from shipping fees, so rest assured that our shipping rates reflect an average of what it costs to get our guaranteed products safely to your door.
We charge one low flat rate for shipping our products even if your order requires multiple shipments. If you have any questions, would like to purchase expedited shipping, or have quetions about shipping to Alaska or Hawaii, please call us at (877) 309-7333.


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We learned last year that John Saunders had been shopping memoir about his rough-and-tumble life on the streets of Toronto. We wouldn't have guessed his life was that rough-and-tumble, but what do we know?
Saunders is a former All-Star hockey player but has mostly been an NBA guy — along with "moderating" those sports reporter people — since coming to the states. Many will remember his palpable anger at Detroit fans after the Palace Brawl in 2004, calling Pistons fans "punks" and "sissies." You go, John Saunders!
So: Do you like the John Saunders? Do you not like the John Saunders? Hit it up.