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Cluster computing for the classroom
Kyril Faenov is the General Manager of the Windows HPC product unit. Before founding the HPC team in 2004, Kyril worked on a broad set of projects across Microsoft, including running the planning process for Windows Server 2008, co-founding a distributed systems project in the office of the CTO, and developing scale-out technology in Windows 2000. Kyril joined Microsoft in 1998 as the result of acquisition of Valence Research, an Internet server clustering startup he co-founded and grew to profitability by securing MSN, Microsoft.com and some of the world's other largest web sites as its clients.
Rich Ciapala is a program manager in Microsoft HPC++ Labs, an incubation team within the Windows HPC Server product unit. Rich joined Microsoft in 1992 and has held a number of different positions in technical sales, Microsoft Consulting Services, the Windows Customer Advisory team and the Visual Studio product team.
Kyril Faenov and Rich Ciapala discuss a new HPC++ Labs project that enables students to run computation-intensive experiments involving large amounts of financial data.
JU: What Rich just demoed, which we'll show in a screencast, is how a financial model can be deployed to a server that acts as a front-end to a compute cluster. It's a nice easy way for students to use a model developed by a professor, select a basket of securities, run a very intensive computation on them against large chunks of data, and get answers back in an Excel spreadsheet. The bottom line is that the students can run an experiment using a level of computing power that was never before so easily accessible.
KF: Yeah, because of the complexity involved in deploying systems like that, acquiring the data, and curating it, a lot of universities don't have this kind of infrastructure in place. So for a number of students who haven't done this before, this will make it available for the first time. For others who have, it will make it quite a bit easier.
JU: Now these are not computer science students who are learning about high performance computing, and about writing programs for parallel machines, these are students who are learning about financial modeling, and this just makes a tool available to them that can accelerate that.
KF: Precisely. Most of our HPC customers are scientists, or engineers, or business analysts, not computer scientists. They're folks who use mathematics, statistics, differential equations ... sometimes not even math directly, but applications that encode these mathematical models to do research, or engineering, or risk modeling, or decision making. To them it's just a tool, and they want to use it in the way they use PCs today, as transparently and straightforwardly as possible.
JU: What's the situation today for most people? In the case of the covariance model Rich showed in the demo, if it weren't being done like that, how would it be done?a
KF: You can do it in Excel, or MATLAB, or SAS, on the workstation. So you'd acquire the data, and use your preferred tool ...
JU: ... and wait a long time ...
KF: ... and wait a long time. And if you want to do a significant amount of data -- like a year's worth, for a large number of stocks -- it might not even be possible at all.
Or you might load it up into a server, but then you have to figure out how to write an application, how to deploy it out to the server, then figure out how to submit the data to the model, pull it back, integrate into the visual analytic process.
This multi-step process is exactly what our HPC customers are running into. They're expressing the models and doing the design on the workstation, using any number of tools. They do the analysis of the results, and visualization, on the workstation. But large-scale computation runs somewhere else. It might be in their organization, it might be out on the Internet, but it's a very disjointed process.
JU: There are clusters out there in academia, and there are people doing these kinds of things, but the point is that hasn't been woven together yet.
KF: That's right. In 2004 the U.S. government published an assessment of U.S. competitiveness in high performance computing. The first recommendation was, and I'm quoting:
Make high performance computing easier to use. Emphasis should be placed on time to solution, the major metric of value. A common software environment that spans desktop to high-end systems will enhance productivity gains.
That's what we're starting to see in the HPC community. Not just getting the systems running as fast as possible, but figuring out how the workflow, the creative element of the scientific process, can be optimized.
JU: So, Rich and I talked about the particular model used in his demo is in a class called parameter sweep, which he distinguishes from the more distributed and chatty kinds of applications. In this case, you can send a batch of data down to a node, it can think about it for a while then give back an answer, and there doesn't need to be much communication. Is that the optimal scenario for this architecture?
KF: Actually, it's optimized for a broad range of HPC applications. In fact, the major goal of the first release of the product, Compute Cluster 2003, was MPI-style [message passing interface] applications. There are a lot of these in engineering and in the environmental space. You're modeling some kind of physical process, and you build a mesh or grid that takes a large physical process or body, partitions it, does computations on local areas, but then has to frequently exchange data across the partitions. Think about a car crash simulation. You might partition the hood of the car into a lot of pieces, every one computed separately, but as the deformation is happening the forces need to be exchanged. Or weather modeling, where heat exchange happens across partitions.
JU: There's a high degree of data interdependence.
KF: Exactly. When you you have an interdependent problem, you use MPI for that. We worked with the team at Argonne National Labs that releases the open source reference implementation of MPI, and we've adopted that in our product, optimized the performance and security on Windows, and integrated it into the stack.
JU: Right, I knew about the MPI layer in the cluster product. But it seems that the system we're looking at here, for professors to enable students to experiment with financial modeling -- that one is targeting the other class of application
KF: Right. There is a large class of what we call embarrassingly parallel problems, a lot of statistical analysis falls into that category, and media rendering, where you have a lot of independent tasks. And that's what we have here, because every pair of instruments that needs to be compared is an indepdendent task. What you need to do is spray those tasks across a cluster. We have a solution that makes that much more approachable.
JU: So in this case, that entails mapping the input parameters to a set of work items.
KF: Correct.
JU: OK. And outside the financial domain, where else will this style be popular?
KF: We'll see this in a range of disciplines. This particular example uses data from an external source -- in this case, the stock market -- and it's looking for patterns of correlations between different signals. This paradigm is broadly applicable. If you think about, for example, clinical research, where you have data coming in from hundreds of patients, where the data includes many parameters about their health condition, and you're looking for disease markers or drug reactions -- you're doing correlation analysis among the diffeerent signals.
Or you might have data coming in from sensors deployed in oil and gas pipelines for safety monitoring, or environmental sensors, everywhere you have instruments producing high volumes of data, where you need to find patterns in data, and optimize the scientific process of developing models that produce insight into the data.
JU: Would you say that these embarassingly parallel problems are low-hanging fruit?
KF: Very much so. And there's another class, Monte Carlo simulation, a method used very effectively across a range of industries to statistically explore different scenarios, for risk analysis and predictive model. It's used in financial services, like insurance, but things like process management in factories can also use it, or logistics chains.
JU: So for the current example, give us a sense of what skill set is required of the professor in order to create the model and make it available to students. There's some .NET programming involved, right?a
KF: Rich, do you want to take this?
RC: Well, you pick your .NET language of choice, and your development environment, which may be Visual Studio. We're making the data available in terms of LINQ, so you need some understanding of that, although for the queries typical of these applications it's fairly basic. And in fact, since it's integrated into the language and you get things like syntax completion, it's probably easier than writing SQL.
JU: There's a framework provided, what does that include?
RC: It does two things. First, it forces you to define the interface for your model in such a way that you can easily build, for example, an Excel front-end to send input and retrieve output. Second, it shows you exactly where you need to do the splitting of the tasks into work items, where you do the spraying of work items to the cluster, and where you put the code that does the covariance and correlation calculations.
KF: The professor focuses on writing the analytics parts, and doesn't have to worry about the fairly complex workflow skeleton that submits the data to the cluster, partitions the work, accessing the results, and then performing the final reduction.
JU: So can focus on creating the pivot table, or using MATLAB, which is where I'd rather be spending my time.
KF: Yes, in a domain you're expert in.
JU: So, who are the guinea pigs for this system?
RC: Our first two are the University of Washington, which did the model we demonstrated, and the University of North Carolina in Charlotte.
JU: Kyril, I know you have big ideas about where this can go. Why don't you paint the picture?
KF: When we started the HPC team at Microsft, we realized it's an actively evolving space. But Microsoft is fairly new to it. Without the benefit of 20 or 30 years of experience, we felt we needed to do something that would help us develop expertise and build up an understanding of not just the technology, but also the usage patterns. So we worked with, and funded, 10 universities worldwide, and that's been very helpful.
We've also created an internal team whose mission is to do incubation. The goal of this team is threefold. First, to prototype and demonstrate the end-to-end solutions that our HPC customers will find beneficial, and what Rich has demonstrated is an example of that.
Second, to help us explore the trend that we see as HPC becomes more and more data-driven. There's still the world where you run simulations, of car crashes or weather. But a lot of new applications are mining data for insight, and doing it in a computationally intensive way. That changes the formula for how HPC is used. In many cases it's becoming impractical to put clusters in customer locations, if you have to ship terabytes or petabytes of data around. Data repositories are starting to act like black holes, if you will, that are pulling computation towards them.
JU: I'm sure that's true in the climate area...
KF: Climate, biology, astronomy, geosciences, everywhere that you start accumulating tremendous data sets. We think there's going to be way that Microsoft can help customers optimize how these services are built, because there's no established architecture today.
JU: Jim Gray was always talking about how it's becoming necessary to Fedex hard disks around the world because there's no other way to move the data to the computation. But instead you're proposing to move the computation to the data.
KF: That's right. We want to incubate a few of these high-value data-centric services, and demonstrate the best practices for doing that while providing free access to academic institutions. That'll help us understand what's involved in operating these services, and potentially we might imagine Microsoft running a few of them.
Then the third goal for the incubation team is to flow the requirements for doing these things into software, so that customers can do this as easily as possible themselves. One of the challenges today is that there's a dichotomy between these very large-scale Internet services being built -- by Microsoft, Yahoo, Google, and others -- but they're in their own world. Customers can't take a slice of that infrastructure and deploy it in their environments.
At the same time, we keep on building off-the-shelf software that people install on their infrastructure, and we're just now learning what it takes to run HPC services using that software. So we want to make sure there's a tight coupling between the team that builds the prototypes and runs the services, and the team that implements off-the-shelf software, such that we run our services using the products that we build. And at same time, we want to make it a turnkey operation for customers to stand up these services themselves.
JU: That's a key point, so let's underscore it. We're seeing the emergence of a small set of what I call intergalactic clusters, which are one-of-a-kind things, and they are not replicable. They do interesting and powerful things, but you can only do things with them on their terms.
Your notion is that you want to maintain parity, and ensure that you can always replicate what's happening in the cloud if you need to.
KF: Exactly. For example we just talked about the gravitational pull of data. Imagine you have an astronomy site that accumulates a petabyte. You can try to put it on one of these intergalactic clusters, but that's maybe not what you want. Maybe the most optimal thing is for you to stand up a 1000-node cluster with each node having a terabyte of disk. We want to enable that. We want to be able to tell our customers: Here's how we run this large-scale data-driven HPC applications, and here's how, within a day or two, you can stand up one of these yourself.
JU: So you even see some potential consumer applications for this, don't you?
KF: Sure. Think about search. We can only find answers to questions that have already been answered. But imagine if your questions require novel insight to data. For example, Microsoft HealthVault is starting to accumulate a lot of health data.
JU: Right, so what are my cancer survival prospects given the specifics of my case, and in light of a large body of data about other people?
KF: Or help me do a predictive analysis on my risk of flood or hurricane damage, not for the region in general, but for my house, given the weather and geographical information that's available, and maybe given a few sensors that report data specifically for my house.
To enable these applications, you have to create a platform that makes it possible to curate data, and develop applications that run on top of it. What you see in the service we just demonstrated is a first example of that.
JU: OK, thanks guys.


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Revision as of 23:27, 3 December 2008
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General Warning
The next generation of the GRand Unified Bootloader (GRUB2) is still under development and therefore all usual points apply. GRUB2 may fry you computer, burn your house, or eat your cat. You've been warned! For most people, except those with more exotic configurations, GRUB2 should just work.
Installing Grub2 package
First install grub2 with pacman
pacman -Sy grub2
Edit the grub2 configuration file with your settings. The 'old' menu.lst is replaced by a new file called grub.cfg
nano /boot/grub/grub.cfg
Note: Use hd[a-z] for ide and sd[a-z] for scsi and sata
Here is an example of a simple configuration file:
# Config file for GRUB2 - The GNU GRand Unified Bootloader # /boot/grub/grub.cfg
# DEVICE NAME CONVERSIONS # # Linux Grub # ------------------------- # /dev/fd0 (fd0) # /dev/sda (hd0) # /dev/sdb2 (hd1,2) # /dev/sda3 (hd0,3) #
# Timeout for menu set timeout=5
# Set default boot entry as Entry 0 set default=0
# (0) Arch Linux menuentry "Arch Linux" { set root=(hd0,1) linux /vmlinuz26 root=/dev/sda1 ro initrd /kernel26.img }
## (1) Windows #menuentry "Windows" { #set root=(hd0,3) #chainloader +1 #}
Installing or Restoring GRUB to the Master Boot Record
GRUB may be installed from a live environment, or directly from a running Arch install.
In most cases, installing grub2 would be as easy as running the grub-install command as root:
# grub-install /dev/sda
where /dev/sda is the destination of the installation (in this case the MBR of the first SATA disc)
Alternatively, you should be able to install grub2 by booting the system and running the grub command as root:
# grub {this section is still incomplete, some steps should be added!!!}
Boot loader configuration
The grub configuration is done in this file:
Be warned this section isn incomplete, feel free to put all missing configuration options here!
- (hdn,m) is the partition m on disc n, numbers starting with 1
- set default=n is the default boot entry, that is choosen after timout for user action
- set timeout=m time m to wait in seconds for a user selection, before default is booted
- menuentry "str"{entry options} title string 'str' for a boot entry & basic layout
- set root=(hdn,m) base partition, where the kernel is stored to
- linux /path ro root=/dev/device initrd /initrd.img use the root option, if the kernel not placed in /
- chainloader +1 sets root active and gives booting procedure to its boot-loader (for Windows, f.e.)
Dual booting
These are the two most common ways of configuring the grub.cfg file. For more complex uses, feel free to add descriptions here.
Dual booting with Windows
Add this at the end of your /boot/grub/menu.lst. This assumes that your Windows partition is [s/h]da2.
# (2) Windows XP menuentry "Windows XP" { set root=(hd0,3) chainloader +1 }
Note, that although commonly believed to be the case, Windows 2000 and later versions do not need to be on the first partition to boot. If the Windows partition changes number (i.e. if you after install add a partition before the windows partition), you will need to edit the Windows boot.ini file to reflect the change (see this article for details on how to do that).
Dual booting with other linux distros
This is done exactly the same way that Arch linux is loaded. Here we assume that the other distro is on partition [s/h]da3.
menuentry "Other Linux" { set root=(hd0,2) linux /boot/vmlinuz (add other options here as required) initrd /boot/initrd.img (if the other kernel uses/needs one) }
Tips and tricks
To change the colors in GRUB2 you would specify two options in /boot/grub/grub.cfg:
set menu_normal_color=color1/color2
set menu_highlight_color=color3/color4.
Any troubleshooting should be added here

subset: commoncrawl


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Community Updates
From Openmoko
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===gllin GPS driver for GTA01===
===gllin GPS driver for GTA01===
11/29/2007 - Thanks to a tremendous amount of hard work by many people, we have ready
11/29/2007 - Thanks to a tremendous amount of hard work by many people, we have ready
a release of gllin, the GPS
a release of gllin, the GPS . Instructions at [http://lists.openmoko.org/pipermail/community/2007-November/011916.html] or grab the ipk directly from [http://3rdparty.downloads.openmoko.org/gllin/].
===850 MHz band not supported in USA+Canada (e.g. comment 24 on bug #256)===
===850 MHz band not supported in USA+Canada (e.g. comment 24 on bug #256)===
Revision as of 21:22, 16 January 2008
Even though OpenMoko strives to keep the community informed of the development progress, OpenMoko does not provide delivery dates. Instead, OpenMoko reports the project status here and on the openmoko-community mailing list.
The status is usually updated at least twice a month, usually by Michael Shiloh. Updates are also mailed to the community mailing list (see below for previous updates), and major updates are also sent to the announce list.
You are invited to add questions or topics you think should be included in the Community Updates.
The latest Community Update was posted to the community mailing list on January 10.
Discussion of current issues
GTA01 Advanced Kit price reduction
12/20/2007 - We have dropped the price of the GTA01 Advanced Kit from $450 to $399. I'm pretty sure that's effective immediately and should be reflected at our web store right now.
The price of Base Kit remains the same.
GTA02 hardware design and test
The information below has been collected from various sources, feel free to add questions and comments here.
While writing a device driver for the new battery which provides an accurate counter of the charge state of the GTA02, the driver developer discovered that the device driver does not get a reading of the charge state due to a very long response time with only one I/O signal when trying to read the charge state. To be able to read the battery status properly, it has been written that it will be necessary to re-design that part of the GTA02 for hardware version GTA02A5 to use two I/O signals to reduce the response time (one for transmitting commands, one for receiving data?). Bug 957 may have more information.
12/06/2007 - GTA02a5 is a minor variation from GTA02a4, so it shouldn't take very long. We are waiting for confirmation of Wifi and a few other parts of the GTA02a4 hardware before we manufacture even a small test run of GTA02a5.
gllin GPS driver for GTA01
11/29/2007 - Thanks to a tremendous amount of hard work by many people, we have ready a release of gllin, the GPS driver. Instructions at [1] or grab the ipk directly from [2].
850 MHz band not supported in USA+Canada (e.g. comment 24 on bug #256)
The GSM chip set is capable of quad band operation but the circuit implemented in GTA02 only supports 3 bands. Currently GTA02 supports only 900/1800/1900MHz.
11/29/2007 - We would like to offer an 850/1800/1900MHz version of GTA02 for areas that need it. We are looking into whether this is feasible or not. This requires a number of changes (components, firwmare, calibration, etc.) and so is uncertain until we test it.
12/09/2007 - Since the GSM section is essentially the same between GTA01 and GTA02, we thought a good experiment would be to modify a couple GTA01 handsets for 850MHz and to test them out here in the USA.
12/20/2007 - Due to the enthusiastic response I received to my request for testing volunteers I've asked our hardware group to modify a few more phones. I don't know when, or even if, they will be able to do this. Meanwhile, I'll be sending out the units I have to the testers, along with a simple test plan.
We have no intention of manufacturing 850MHz GTA01s, nor can we modify user's phones this way. We modified a couple of units ONLY so that we could test the circuit that we might use in GTA02. When the experiment is done, these modified units must be returned to OpenMoko.
Conversion of GTA02 to quad band would require major changes and so will not happen.
Delivery of a GSM firmware update for the 3G SIM bug (#666)
A bug in the GSM firmware prevents some USA 3G SIM cards from working properly. The bug has been fixed, but since the GSM module is under extremely tight legal protection, it is not clear whether or how we can allow customers to perform this upgrade themselves.
12/09/2007 - We've been informed that everything legal has been agreed upon by all parties regarding the process that would allow you to upgrade your own GSM firmware. All that remains is to get everything signed. Apparently the process of getting things signed takes a few weeks!
12/20/2007 - Meanwhile, we have resolved the difficulties I was having performing the upgrade, and I am now able to upgrade your handsets. Anyone interested in having me do this should contact me at email@example.com.
Questions or Topics you think are missing
SMedia 3362 Documentation & OpenGL ES Drivers
There is an open source kdrive driver being written for the GTA02 which will use hardware to accelerate the XRender extension. While the chip is capable of 3D graphics, no OpenGL ES driver/library is avaliable and OpenMoko developers will not be writing one in the near future (although they have not ruled it out in the long-term).
Documentation for the SMedia 3362 has been promised (see this post). However, this refers to documentation OpenMoko developers will be writing themselves, not the technical documentation SMedia have provided OpenMoko with. The OpenMoko developers had to sign an NDA with SMedia to obtain this documentation and are therefore unable to pass this information on to community developers. (See this post for details)
Power Management on the Neo1973
It is still not clear if it will be possible to have "reasonable" battery life on the Neo1973 (GTA1) hardware or if there are hardware problems that make this impossible.(see this post). Can this be officially clarified.
Previous Community Updates
- September 28, 2007 Community Update
- October 12, 2007 Community Update
- October 13, 2007 Community Update
- October 15, 2007 Community Update
- October 16, 2007 Community Update
- October 25, 2007 Community Update
- October 31, 2007 Community Update
- November 6, 2007 Community Update
- November 13, 2007 Community Update
- November 26, 2007 Community Update
- November 29, 2007 Community Update
- December 09, 2007 Community Update
- December 20, 2007 Community Update
- January 2, 2008 Community Update


text:
It is difficult to believe that January is almost over, but here we are. It is a time for introspection and for planning. We hope you are giving some thought to a visit to Cape Cod this year. If you are, we hope you will come to Sandwich for a truly wonderful vacation or, if time only allows, for a quick get-away. We love helping guests celebrate anniversaries and birthdays.
If you are attending a wedding in Sandwich this year, you may have already seen the 1750 Inn at Sandwich Center listed on a "save the date" card. Many brides who have chosen one of the beautiful settings in Sandwich for their wedding send out these cards to people who will be attending encouraging them to make their lodging reservations as soon as possible. If you have any questions, we hope you will give us a call. We would be happy to help you in any way that we can.
If you are a first time visitor to Cape Cod, there is a wealth of information on our website about the Cape and Sandwich. As our lovely and quaint little village is the oldest in the area, there is much historic and wonderful here. Our inn is nestled historic Town Hall Square and is just across the street from the world renowned Sandwich Glass Museum and the recently renovated Sandwich Town Hall. Just up the street you will find the 1600s Dexter Grist Mill, which operates grinding corn during the summer months, and the Hoxie House, the oldest home on Cape Cod. Just a short walk up the hill is Heritage Museums & Gardens, surely the Crown Jewel of Cape Cod. Exploring these wonderful places will fill a day for you quite easily.
Sandwich is a great place to choose as a base when you are planning your vacation. You can easily day-trip to the islands of Nantucket and Martha's Vineyard from here. If you are going to Nantucket on the 9 am ferry, we will happily send along a take-away breakfast for you to enjoy on the hour-long ferry ride over to the island. Be sure to check out the packages we have put together for you convenience in visiting these lovely islands.
We offer several packages that may be helpful to you in arranging you visit here. We have a "Whale Watch" package that offers two locations from which to depart and a "Sandwich by the See" package that has tickets to some of the most wonderful attractions in Sandwich and is a wonderful package for a great three-day get-away.
A trip to the Cape would not be complete without a stroll on the beach. We have lovely beaches here and our Sandwich Boardwalk was recently named one to the most beautiful in the world. Best of all, it is just a short walk from our bed and breakfast inn.
Come for a visit. Our promise to us is a pristine and charming place to stay and the warmest hospitality on the Cape....Your Innkeepers, Jan & Charlie.
Friday, January 18, 2013
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A Complete Quick Immersion Video Instruction System
Our Planet X 101 series offers comprehensive information about the approach of the Planet X system and what that means for humanity in the years to come. Based on science, hard data and years of observations, this is the fastest and simplest way to immerse yourself in the topic. This value package offers a complete 3-disc set of copyable DVDs.Watching the complete series takes approximately 3.5 hours and the depth of information presented is the equivalent of a personal research effort, of three years or more.
Who, What, When, Where, Why and HowOctober 28, 2013 [1:01:21]This is the best starting place for those new to the topic of Planet X, because if presents a foundation understanding of the topic. It explains the various names used to describe these objects and offers a comprehensive history of the topic dating back to 1781 through to the present. For newbies, it is a real time saver, because it condenses months if not years of personal research for most, into a one-hour presentation. Deep ImpactMay 30, 2014 [0:19:59] This video features an in-depth analysis of fireball observation statistical trends as published by the American Meteor Society (AMS). What you will see is a clear upward trend in large fireballs and bolides that has been steadily building since 2009. Given that oceans cover 71% of the Earth's surface, if this trend does not reverse itself soon, it is likely that we will witness a deep impact event in the near future. Such events generate catastrophic tsunamis such as the one depicted in the film Deep Impact (1998). Nibiru NearingJune 8, 2014 [0:42:09]We present several observations of two bodies in the Planet X system. Nemesis the small brown dwarf companion to our own sun and it's outermost orbital, Nibiru (Planet X, Hercobulus.) Nibiru has been imaged from surveillance cameras in Costa Rica since 2010 and in this video, observations in the USA from 2013 and 2014 are also presented. All of these observations place these two bodies in this system in or near the constellation Ophiuchus, exactly as predicted by Nostradamus.Pole ShiftJune 8, 2014 [0:50:00]For those new to the topic, this program offers recent observations of the Planet X system bodies, the Nemesis brown dwarf and its outermost orbital, Planet X. It offers a clear and comprehensive overview of the celestial mechanics involved in the coming pole shift a how these two bodies in space will gain a lithosphere lock on the outer skin of our planet, thereby causing a great tribulation for Earth. Proof of NibiruJune 17, 2014 [19:29]As they used to say in WWII, "if you're not taking flak, you're not over the target." There is no doubt that the PlanetX101.com series is over the target because debunkers are throwing up everything they can, including the kitchen sink. In this video, Marshall debunks these debunkers with the very science and facts they do not want you to know.
©2018 Knowledge Mountain Media, Inc.


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Apple is cornering a new market: the cockpit.
The Cupertino-based technology company has won approval from the Federal Aviation Association to have pilots use iPads while flying.
American Airlines reportedly won the approval from the FAA for its pilots to be able to use Apple's tablet computer "as electronic chart and digital flight manual readers."
The airline becomes the first to win approval to use the tablet, which will reportedly replace 35 pounds of paper per tablet used.
That translates to about $1.2 million in annual fuel savings.


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The Army is designing a new vehicle-mounted Active Protection System that can identify, track and destroy a wide range of incoming enemy fire to include rocket propelled grenades and anti-tank missiles, service officials said.
Although the effort is geared toward protecting the Army's new infantry carrier, the Ground Combat Vehicle, the thinking is more broadly oriented toward developing an APS that can protect a range of light, medium and heavy vehicle platforms from Strykers to Bradleys and even light vehicles, Mary Miller, deputy assistant secretary of the Army, Research and Technology, told Military.com in an interview.
"We are looking for a common architecture that we can put in tactical through combat level platforms with plug and play aspects. We want to expand the architecture as you are going into a heavy combat systems to address the threats a heavy combat system would face," said Miller.
Miller referred to a recent Pentagon report that highlighted results from an evaluation of seven foreign and domestic APS technologies. The report, which resulted from congressional language in 2008 asking for such an assessment, found that none of the tested APS technologies were mature enough to field on U.S. platforms. Further development, test and evaluations were required, the report found.
"What we found is that there is no system that is quite ready yet. There are a lot of issues that still need to be worked out," she said.
One analyst said APS is among the most challenging technological areas facing the Army.
"This is one of the most challenging areas for the Army of the future. The concept of operations, responsiveness of the systems and potential for false alarm rates are all challenging," said Daniel Goure, vice president of the Lexington Institute, a Va.-based think tank.
An APS is planned for the Army's GCV, a next-generation infantry carrier designed to achieve a new combination of protection, mobility, network technologies and firepower. The GCV is now in its Technology Development phase; however, like most major Army acquisition programs, its future is uncertain in light of current budget pressures, Army officials have indicated.
Nevertheless, APS would figure prominently in the survivability equation of the GCV as it would likely impact the level of armor needed for certain missions.
Without APS, a vehicle may need up to 52 tons of passive ballistic armor to counter known and anticipated threats, whereas a vehicle with the right kind of integrated APS technology may only need 18 tons of armor, Miller explained.
Along these lines, developers of the GCV have often talked about modular armor technology, meaning armor panels or coupons which could easily be added or removed depending upon threat levels and mission requirements.
Army scientists, engineers and program managers are currently exploring the wide range of existing APS technologies with a mind to leveraging the best possible solutions for the future.
There are a number of foreign and domestic APS systems in existence at various stages of development. The concept of an APS has been around for many years. Essentially, most systems use a sensor, processor and interceptor designed to find, track and destroy approaching enemy fire in a matter of milliseconds.
Some examples include Raytheon's Quick Kill APS technology -- once part of the Army's former Future Combat Systems program. Quick Kill uses an active electronically scanned array radar to track approaching threats. It then links the information through a computer to cue a vertically launched countermeasure missile designed to quickly intercept the incoming fire. Proponents of Quick Kill praise its speed and hemispheric or 360-degree coverage area.
Another U.S. system is called Iron Curtain, made by Artis, a Va.-based technology firm. Iron Curtain uses radar and optical sensors combined with high-speed computing and explosively formed penetrators to destroy approaching threats.
International variants of APS include the Israeli Defense Force's Trophy system, which intercepts approaching enemy fire with a "shotgun" like blast. The system has been integrated on Israeli Merkava main battle tanks. Another Israeli APS is called Iron Fist, a system made by Israeli Military Industries. The system uses an infrared detector to track approaching enemy fire and then fires an explosive projectile interceptor. The interceptor casing is made of combustible materials so no fragmentation is formed.
Additional foreign APS examples include a German firms' AMAP-ADS hard-kill system and a Russian system called Drozd, to list a few among many. South Korea and Sweden are also reported to have APS technologies.
One of the challenges when it comes to maturing designs and solution for APS is thinking carefully about how and where the intercept occurs, Miller explained.
For example, a collision or intercept of an incoming projectile can cause fragmentation, shrapnel or a small explosion, creating a need to have the right protocol to ensure personnel are not in the vicinity of a vehicle. Also, having a sense of these details can help planners establish the right amount of armor for a platform.
"Basically, you are launching an interceptor and you are going to meet up with a threat that is inbound into your platform. You are going to do something to cause that threat to be kicked out of the way or to self-explode," Miller said. "However, if you cause a detonation beyond the range of your platform, you are still going to have shrapnel that is coming at you, so your platform needs some level of passive armor."
At the same time, the Army's APS research is looking at what's called "soft-kill" protection, meaning an ability to electronically jam, block or thwart an incoming threat without causing an explosion, Miller added. Goure said the Army's thinking about "soft-kill," jamming and electronic intercepts is excellent thinking about technological trends and potential breakthroughs for the future.
"Most of the APS are variations of some kind of kinetic system. We are now at the stage where directed energy or electronic kills may be possible. That way, you don't have to blow things up in proximity to your own systems and people. Perhaps there will be a hit-to-kill laser system that emerges to counter an anti-armor guided missile?" Goure said.
At the same time, the Army is also researching and looking at "hard-kill" solutions, which use an interceptor to collide with and destroy enemy fire. The main thrust of the research is aimed at developing what Miller called a "common architecture," a set of technical standards aimed a creating a versatile technology that can be tailored to a given threat scenario.
"We're developing a common architecture with PEO GCS (Program Executive Office Ground Combat Systems) and PEO CS & CSS (Program Executive Office Combat Support and Combat Service Support). We're trying to see from an S&T perspective if you can have a common base architecture that extends from tactical to combat vehicles," Miller said.


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City of Lincoln
Mayor's Office
2004 Media Releases
Mayor Coleen J. Seng and the Lincoln-Lancaster Women's Commission (LLWC) today released the findings of a study which found that women are under-represented on local boards, commissions and task forces. The study, "A Place at the Table," gathered information on 219 boards in Lincoln and Lancaster County. Of the 2,453 positions on those boards, 1,720 seats (70.1 percent) were held by men, and 733 seats (29.9 percent) were held by women.
"According to the census, women make up 51 percent of the population in Lancaster County, so this under-representation is a very real issue," said Mayor Seng. "Society continues to make progress in the area of gender equity, but this study is another indication that there is still work to do. It is extremely important for women to have a place at the table where important decisions are being made that impact families and our community."
Bonnie Coffey, Executive Director of the LLWC, said the organization has embarked on a long-term project of providing women's leadership opportunities. The project includes the establishment of a talent bank.
"The Commission will recruit qualified women to complete the enrollment form, creating a reservoir of potential candidates," said Coffey. "LLWC will work with area businesses and organizations to make available candidate information in an effort to increase female representation on boards, commissions and task forces."
In its research, LLWC staff used annual reports, company web sites, the Nebraska Secretary of State's office and personal contacts. The survey asked how many seats the institution has on its board of directors, and how many of those are currently occupied by women. The information was collected from June through September of last year and may not be representative of the current composition or membership.
The study looked at four categories – Lincoln's largest employers (for-profit), non-profit organizations, local government and elected offices. Of the 733 seats held by women, 61.3 percent were on not-for-profit boards, 28.6 percent were in local government, 3.8 percent were in elected office, and 6.3 percent were on for-profit boards. Other findings:
The report will be available on the City web site at lincoln.ne.gov. Free copies are available from 8 a.m. to 4:30 p.m. weekdays at the LLWC, 440 South 8th Street, Suite 100. Citizens can also call the Commission at 441-7716 to request that a copy be mailed.


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Cottage Couleurs d'Ardenne (Saint hubert Luxembourg)
Environ 31 km de Sensenruth
5 persons
A city cottage, newly opened, ranked 3 epis, in the heart of the European Capital of Nature and Hunting, 500 m of the Ardennes forest, close to restaurants and shops ,on ... Read more
Cottage A l'Ancienne Forge (Sainte marie chevigny Luxembourg)
Environ 32 km de Sensenruth
9 persons
The old forge (1900)typical of Ardennes and fully restored can accommodate 9 people. (Classified 3 starsin Belgium). With its charm, elegance and comfort ,you will be seduced by this old ... Read more
Cottage L'Essecalpade (Falmagne Namur)
Environ 44 km de Sensenruth
12 persons
10 children
Housed in the charming village of Falmagne, entwined off by the waters of the Meuse wandering one hand and Lesse other hand, our home, built in 1860, will welcome you with ... Read more


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Our mahogany stretch leather belt is interwoven with an elasticated braid. It is pulled together with a matching brown trim and hand stitched to a solid brass buckle in an English Matt finish.
This belt has no specific holes meaning the buckle prong passes easily through the webbing allowing for a comfortable and adjustable fit.
Designed in England. Made in Italy
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ROCHESTER — Dana Farber Marathon Challenge Benefit Dance will be held on Friday, April 5 from 7:30 p.m. until 11:30 p.m. at the Rochester Elks Lodge. The evening will feature Someday Happened, an eclectic, high energy local band, rocking it from the '70s to today. As well as live music, there will be an auction of several items generously donated by local businesses, munchies and a cash bar.
Local resident Ty Powers will be running in the Boston Marathon in April as a member of team Dana-Farber, and all proceeds from this event will support his team's fundraising efforts.
Ty lost his father, Mike Powers, to cancer last year, and will be running the Boston Marathon in his memory. Ty's wife Carrie was diagnosed with breast cancer at the end of 2012, just months after his commitment to join team Dana-Farber in their cancer research fundraising efforts.
Donations are still being accepted, please visit www.rundfmc.org/2013/typ or contact Ty Powers 743-6812 to make a donation and/or more ticket information.
Bruce & Laura Boudreau are the co-chairs of the event at the Elks.


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Next-generation sequencing (NGS) is a high-throughput methodology that enables rapid sequencing of the base pairs in DNA or RNA samples. Supporting a broad range of applications, including gene expression profiling, chromosome counting, detection of epigenetic changes, and molecular analysis, NGS is driving discovery and enabling the future of personalized medicine.
Comprehensive solutions
NGS research areas and applications
NGS Workflows & Data Management
Manage and track genomic data for NGS or Sanger sequencing in one platform.
Leading in NGS
Targeted NGS performance of Oncomine Assays and NCI-MATCH Trial Assay
The Oncomine Comprehensive Assay and NCI-MATCH Trial Assay (based on the Oncomine Comprehensive Assay) have demonstrated robust performance even with very limited FFPE samples. See the data ›
Featured application: liquid biopsy research
From sample to answer, Ion Torrent technology enables comprehensive solutions for analysis from cell-free DNA (cfDNA) and cell free RNA (cfRNA). Our liquid biopsy NGS portfolio now offers a new, broad, 52-gene pan-cancer assay
Check out our new cfDNA white paper that discusses the analytical methods used in verification of the Oncomine Lung cfDNA Assay with the Ion S5 XL System.
How does Ion Torrent NGS work?
Ion Torrent next-generation sequencing exploits the fact that addition of a dNTP to a DNA polymer releases a hydrogen ion. We measure the pH change resulting from those hydrogen ions using semiconductors, simultaneously measuring millions of such changes to determine the sequence of each fragment.
The semiconductor approach—unlike optics or modified nucleotides used in other NGS technologies—helps you implement a fast and simple workflow that scales to your research needs across multiple applications including inherited disease, oncology, infectious disease, human identification (HID), human leukocyte antigen (HLA) typing, and agrigenomics.
Our targeted sequencing approach introduces a PCR-based sequence enrichment step using Ion AmpliSeq technology that focuses on genes or even genetic variants of interest; a good example is the targeting of oncogenes and tumor suppressors in a cancer research study.
Next-Generation Sequencing Support Center
Find tips, troubleshooting help, and resources for your next-generation sequencing applications.
For Research Use Only. Not for use in diagnostic procedures.


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The Izod IndyCar Series opens its 2013 season Sunday with the Honda Grand Prix of St. Petersburg, Fla. The series will hit Long Beach on April 21 and finish at Auto Club Speedway in Fontana on Oct. 19.
Last year's MAV TV 400 in Fontana was as thrilling as the points battle. Ryan Hunter-Reay parlayed his fourth-place finish in the finale to win the title by three points over Will Power. Scott Dixon was third and Helio Castroneves fourth in the standings, all within 37 points of Hunter-Reay.
"If this championship did anything, it made me hungrier than ever," said Hunter, who will begin his fourth season with Andretti Autosport. "I definitely learned a lot (in 2012). I learned a lot about consistency and what it takes to put together a few race wins in a row. It was definitely a season of firsts.
"I learned a lot about dealing with the pressure of championship fights and kind of channeling that into positive energy to make it really benefit you when you need it. But it's something that I'll use in the future for sure going forward."
Power, who drives for Team Penske, finished second for the fourth time, doesn't plan to change his approach much.
"Just a couple little details really. It's really nothing too big. It's different every year," Power said. "I hope I'm in contention in the end and have a chance at it really."
Chevrolet also posted a better season than rival Honda by winning 11 of 15 races. Dario Franchitti won the Indianapolis 500 with a Honda, however.
It wasn't the type of season Honda was pleased with.
"Honda has done a lot of work with the engines over the winter," said Franchitti, a four-time series champion. "Although the car may look the same outside, underneath there will be a lot of tiny details that will be different and hopefully give us an increase in performance."
The West Coast Stock Car Hall of Fame will grow to 118 with the induction of the Class of 2013 at the Meritage Resort and Spa in Napa on June 20, the same weekend as the NASCAR Sprint Cup race in Sonoma.
The latest inductees include three NASCAR champions, a Daytona 500 winner and a former race track owner and developer.
Ron Hornaday Jr., whose initial success was on Southern California short tracks, is a four-time NASCAR truck series champion. Chad Little won the 1987 NASCAR Winston West title and is the current tour director for the Camping World Truck Series. Randy Lynch was the championship car owner in the 2007 NASCAR K&N Pro Series West competition.
Also to be inducted will be Derrick Cope, who won the 1990 Daytona 500 when Dale Earnhardt suffered a flat tire on the last lap. Buddy Jobe, who developed Phoenix International Raceway, is the fifth inductee.
Established in 2001, the mission of the West Coast Stock Car Hall of Fame is to preserve history and heritage of the importance the West Coast competitors.
With Antron Brown and Johnny Gray winning at last weekend's NHRA Gatornationals in Top Fuel dragster and Funny Car, respectively, team owner Don Schumacher reached the milestone 200-win plateau.
Schumacher, whose teams have won in all four NHRA pro classes, is second only to John Force. All of his 218 national event wins have been in Funny Car.
"It's a tremendous reward," said an emotional Schumacher, who will be inducted into the International Motorsports Hall of Fame at Talladega, Ala. on May 2. "I can't say what this personally feels like. When we won both championships in November (at Pomona), my mother passed away on the day of the banquet the next day.
"I haven't had joy really since then … (this) brings a special meaning to all of my efforts out here for all of these years."
His first win was at the 1970 U.S. Nationals, the premier NHRA event of the time.
"I am not someone who ever counts things like that," he said. "I never thought it would happen or even considered it.
"Thanks to all of my drivers. They do an incredible job day in and day out."
The Southern California race track outlook:
It was a rough start for Route 66 Motorplex last Saturday in Victorville. A heart attack in the pits and unexpected high winds that dried the dirt track caused delays with the start.
Unlimited and limited sprint cars and midgets highlight the card again on Saturday at the San Bernardino County Fair grounds. …
Glen Helen Raceway is hosting the second round of the MTA 2-Stroke Championship Series on Saturday. The third and final round is set for April 7.
The team of Destry Abbott, Gary Sutherin and Mark Tilley won the recent 6 Hours of Glen Helen by almost six minutes. Kris Keefer won the Ironman class on the 10.5-mile course. …
VRA Midgets, Senior Sprints, IMCA Modifieds, Sport Compacts, Mod Lites, Go-Karts an Sport Mods highlight Saturday's show at Ventura Raceway in Oxnard. ..
Perris Auto Speedway is dark the next two weekends. The next event on the half-mile clay oval will be the return of the World of Outlaws Sprint Cars on April 13.
It will be only only Southern California appearance by the "touring hombres" of the season.
Notes from the margin of a Toyota Racing notebook:
Drivers from NASCAR and NHRA will play in a charity softball game April 17 in Kannapolis, N.C. The NASCAR drivers will play for The Armed Forces Foundation while the NHRA team has designated Children's Healthcare of Atlanta as its charity. … NHRA has added alcohol dragster and funny car classes to the 28 th Fall Classic Sept. 14-15, at Woodburn, Ore. … Brian Redman, whose internationally acclaimed career as a sports car, Formula One and F5000 racer spanned more than 40 years, will be honored at the "Road Racing Drivers Club Evening with Brian Redman" in Long Beach on April 18. Previous honorees were Dan Gurney, Parnelli Jones, Roger Penske and Jim Hall. … The Pacific Street Car Association and the West Coast Outlaw Pro Mod Association will race at Sacramento Raceway Park on Friday through Sunday in the Nor-Cal Nationals. … What's the Indianapolis 500 worth to the Indiana economy? According to a study by the Indiana University Public Policy Institute, more than $510 million annually.


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A flash of art: action photography in Rome 1953-1973
Photology, 2004 - Photography - 333 pages
The setting: Rome, Italy. The era: the 1950s to the 1970s. The subject: everyone who was anyone in the international jet-set. The theme: hedonism, glamour and paparazzi. It was a time when to be snapped in fashionable Italy, to be a pin-up and to have a mutually beneficial relationship with the paparazzi were the main objectives for a certain crowd. If today the term "paparazzi" carries associations of scandal-mongering, voyeurism and right-to-privacy issues, "A Flash of Art" harkens back to the golden age of a once glamorous trade, when things were more black and white, as it were. Photographs by 22 Italian paparazzi, including Tazio Secchiaroli, Lino Nanni, Elio Sorci, Mario Fabbri and Marcello Geppetti, recall a Felliniesque era. There are a few harbingers of the time to come: pictures of celebrities caught in compromising and/or embarrassing situations. One set of images depicts a riled Anita Ekberg threatening another photographer with a bow and arrow as he tries to catch her arriving home after a night out; another shows Jane Mansfield lying in the street having been accosted by "ballerina" Alma del Rio. But the posed portraits of Hollywood icons Brigitte Bardot and Omar Sharif, the endless shots of gorgeous ladies in sparkly gowns, vamping for the camera, and the dapper men in dark suits and darker glasses are the real showstoppers.
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18 cm Stamp 1959 Vintage gelatin 1960 ca Vintage action photographers Agenzia Elio Sorci Anita Ekberg Anna Magnani Anthony Steel Associati srl pag Ava Gardner Bologna Brigitte Bardot carbon copy Private cm Stamp Agenzia cm Stamp Italy's cm Stamp Lino cm Stamp Tazio cm Two stamps copy Private Collection Copynght Copyright Eredi Marcello Copyright Lino Nanni Copyright Photo Masi Copyright Reporters Associati Dolce Vita Eredi Marcello Geppetti EUO SORCI gelatin silver print Grace Kelly Italy's News Photos Jean-Paul Belmondo journalistic carbon copy Lino Nanni pag Lino Nanni Signed Marcello Geppetti pag Masi srl pag Nanni Signed Private Notes on verso Photo Masi srl PIERLUIGI PRATURLON pnnt Pnvate Collection Reporters Associati srl Richard Burton Rome Rome 1959 Vintage Signed Private Collection Sophia Loren Stamp Agenzia Elio Stamp Agenzia Masi Stamp Lino Nanni Stamp Tazio Secchiaroli stamps Marcello Geppetti UNKNOWN PH UNKNOWN PHOTOGRAPHER Veneto verso Private Collection Vintage gelatin silver Walter Chiari


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Tissue Collection for Studies of Lymph Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01676805
Recruitment Status : Recruiting
First Posted : August 31, 2012
Last Update Posted : October 9, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
- Lab studies help researchers better understand cancer biology. This information may lead to new methods for diagnosing or treating cancer. To develop these studies, researchers want to collect samples from people with cancer or precancer conditions of the lymph system. These conditions include multiple myeloma, different types of lymphoma, and adult leukemia/lymphoma. The samples collected will include blood, urine, bone marrow, and tumor and skin tissue.
- To collect tissue samples to study different types of lymph cancer.
- Individuals at least 18 years of age who have a lymphoid cancer or precancer condition.
- Participants will be screened with a physical exam and medical history.
- Different samples will be collected for study. Blood samples will be collected at the initial testing. More blood samples will be collected at different treatment points. Other liquid samples include urine, bone marrow, and any abnormal fluid. Tumor tissue and skin tissue biopsies will also be collected for study.
- Treatment will not be provided as part of this study.
|Condition or disease
|Hodgkin Disease Lymphoma, Non-Hodgkin Multiple Myeloma Lymphomatoid Granulomatosis Leukemia-Lymphoma, Adult T-Cell
An estimated 79,190 people living in the United States will be diagnosed with lymphoma in 2012, including 9,060 cases of HL, 70,130 cases of non-Hodgkin s lymphoma (NHL) and multiple cases of adult T-cell leukemia/lymphoma. Laboratory investigations conducted in the Lymphoid Malignancies Branch, including analysis of cellular, molecular, genetic and genomic biology are attempting to develop new prognostic and diagnostic models, therapeutic agents and novel treatment approaches for lymphoid malignancies and pre-malignant conditions.
This biology protocol is designed to allow sample acquisition for use in the study of lymphoid malignancies and malignancy precursors, including but not limited to B and T cell malignancies, such as diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL)as well as comparison to tissues from patients without lymphoid disease. A variety of laboratory investigations will be conducted on blood, tumor, bone marrow, urine, abnormal fluid and normal tissue, including analysis of cellular, molecular, genetic and genomic biology in the support of NIH translational trials to develop new therapeutic agents and novel treatment approaches as well as new prognostic and diagnostic models.
Adult patients who meet the following:
- Confirmed pathological diagnosis of lymphoid malignancy or lymphoid precursor, including B-cell and T-cell lymphomas: including but not limited to diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL).
- No known lymphoid malignancy or lymphoid precursor diagnosis and planning a surgical procedure during which blood or normal lymph node(s)/tissue (i.e., those not with pre-determined likelihood of abnormality/malignancy) may be obtained for research studies as part of this protocol.
The purpose of this study is to examine, in an exploratory fashion, a variety of biologic assays relevant to the investigation of lymphoid malignancies.
It is anticipated that up to 60 consented subjects will be studied each year. Thus, an accrual ceiling of 600 consented subjects is planned over 10 years.
|Study Type :
|Estimated Enrollment :
|600 participants
|Observational Model:
|Time Perspective:
|Official Title:
|Lymphoid Malignancies and Precursors: Tissue Acquisition Protocol
|Actual Study Start Date :
|September 21, 2012
Patients with a known lymphoid malignancy or precursor disease to a lymphoid malignancy
Patients without a known lymphoid malignancy or precursor disease to a lymphoid malignancy
- Sample Acquisition [ Time Frame: Ongoing ]Standard exploratory and descriptive statistical methods will be used, as appropriate to the specific biologic assay. Any findings will be reported in the context of this exploratory study, with appropriatecaveats.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 99 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
- Patients with known lymphoid malignancy or precursor disease to a lymphoid malignancy, including multiple myeloma, B-cell and T-cell lymphomas: including but not limited to diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL).
Confirmation of pathological diagnosis.
--Confirmation of diagnosis is required from the Laboratory of Pathology, NCI. Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care or required testing on an NIH research protocol will be used for diagnosis.
- Greater than or equal to 18 years of age.
- ECOG performance 0-2.
- Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document NOTE: Patients enrolling with a
LAR must be co-enrolled on another study.
NOTE: This is optional in all patients and will only be requested if the patient is willing, timing allows, and the following criteria are met.
- Hemoglobin greater than or equal to 10 mg/dL and platelet count greater than 75 K/uL.
- Weight greater than 25 kilograms
- HIV negative
- Prothrombin Time - within normal limits
- Partial Thromboplastin Time - within normal limits
- Medically indicated central line in place or adequate peripheral venous access
- Pregnant will not be eligible for any aspect of this protocol except phlebotomy until conclusion of the pregnancy. Samples from other procedures (e.g., tumor biopsies) would only be collected for this study if the procedure(s) is already planned as part of another treatment protocol or standard of care..
- Active symptomatic major organ disorder that would increase the risk of biopsy or apheresis, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction.
- Active concomitant medical or psychological illnesses that may increase the risk to the subject or inability to obtain informed consent, at the discretion of the principal investigator.
ELIGIBILITY CRITERIA: Non -Lymphoid MALIGNANCIES/DISEASES
The following criteria apply only to patients without a known lymphoid mali nancy or precursor disease, as described:
-Patients without a known lymphoid malignancy or lymphoid precursor diagnosis who have a planned surgical procedure during which blood or normal lymph node(s)/tissue (i.e., those not with pre-determined likelihood of abnormality/ malignancy) may be obtained for research studies as part of this protocol
Patient is appropriate to undergo the surgical procedure planned, and consented for the same, as needed. NOTE: This study will not evaluate eligibility of the patient for surgery.
- Age >= 18 years of age
- Must be able and willing to sign informed consent 2.2.2 Exclusion Criteria
- Pregnant or breast-feeding women will not be eligible
- Active concomitant medical or psychological illnesses that may increase the risk to the subject or inability to obtain informed consent, at the discretion of the principal investigator.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01676805
|Contact: A. Nicole Lucas
|(240) 760-6252
|Contact: Mark J Roschewski, M.D.
|(240) 760-6183
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937
|Principal Investigator:
|Mark J Roschewski, M.D.
|National Cancer Institute (NCI)
Additional Information:
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01676805 History of Changes
|Other Study ID Numbers:
|First Posted:
|August 31, 2012 Key Record Dates
|Last Update Posted:
|October 9, 2019
|Last Verified:
|May 29, 2019
Developing Novel Treatment Approaches
Developing Therapeutic Agents
Analysis of Genetic and Genomic Biology
New Prognostic and Diagnostic Models
Analysis of Cellular and Molecular Biology
Multiple Myeloma
Hodgkin Disease
Lymphoma, Non-Hodgkin
Lymphomatoid Granulomatosis
Leukemia-Lymphoma, Adult T-Cell
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Neoplasms, Plasma Cell
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoma, B-Cell
Precancerous Conditions
Leukemia, T-Cell
Leukemia, Lymphoid


text:
I was lucky enough to receive a great kit to review by Febreeze Home Collection and MyBlogSpark. I love fun new scents, so I was especially excited to review this kit. Giveaway information is down past the review. 🙂
I received the following products:
- Green Tea & Citrus Flameless Luminary and three refill shades (Pomegranate Mango, Cranberry Pear & Willow Blossom), to let a flickering light shine through to accent your room with scent and style.
- Green Tea & Citrus Soy Blend Candle, which has a soft glow and releases the premium fragrance into the air as the candle slowly burns
- Green Tea & Citrus Room Spray, available in an easy, yet stylish spray canister
- Green Tea & Citrus Diffuser, to add a stylish and aromatic touch to the air with scented oils
I loved the idea of the flameless luminary because I have young kids or really, just kids in general who don't always pay attention. I can get the same effect as a lit, flickering candle without the danger of someone getting burnt or my house burning down. 😉 The Green Tea & Citrus scent is nice, but I prefer the Cranberry Pear.
The candle emits a nice amount of scent, but it not overpowering. It seemed to burn evenly each time I lit it. I like the decorative glass & wooden lid that comes with the candle. You can use the lid as a base as well.
The room spray is a bit overpowering at first, but definitely helps rid the area of any odor that was there. I am thinking about using this for Jon's hockey bag, though I am not sure he will appreciate that. LOL! One thing I did like is that you don't have to spray a whole lot to get the effect you are looking for.
I placed the reed diffuser in our bedroom. I don't like to light candles in the bedroom because I am afraid I will fall asleep with them lit. I also haven't had much luck with the plug-ins, as the scent seems to disappear after a couple of days. I was happy with this reed diffuser. The scent is not overpowering & is subtle enough to be able to tell there is a pleasant scent present. The one thing I didn't like was that wooden lid doesn't really attach to the glass….it just sits on top of the glass. This could be a potential hazard for those with kids. I made sure to put mine out of reach of the ones who don't know better.
Now for the fun part! Are you ready???? Febreeze & MyBlogSpark have given me a $20 Walmart gift card to give away! All you have to do is leave a comment on this post and tell me how you would use the Febreeze Home Collection to spruce up a room (or hockey bag 😉 ). This contest will end Wednesday, October 6, 2009 at midnight! I will choose a winner first thing on Thursday morning. You can find coupons for Febreeze products here.
Filed under: Family |


text:
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text:
Hi everyone, I have been doing quite a few exchanges lately, here is the one I sent to Hazel from the
Quietly Stitching blog this week. (The exchange I received from Hazel is shown below) I made the box and covered it with this beautiful fabric from Shabby Fabrics in America, I also made the pinkeeps and little pillow using free patterns from:
Gazette 94 for the rose pattern, please see previous post for the link to this pattern.
Amitie pattern is from DesFilles et une Aiguille here
I made the polymer clay roses and the buttons from polymer clay.
Hazel sent me the most gorgeous stitching set below, I am thrilled with it. Hazel made the gorgeous bag and filled it with the lovely matching needlebook and little scissor pillow.
Thanyou Hazel, I shall treasure them always.
Thankyou for all of the lovely comments, I really appreciate them.
Happy stitching!


text:
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2020 TLM Pilgrimage to the Holy Land
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- Johann: Have only begun to delve into this book and I already consider it the best book on the Church crisis released to date. I especially love the copy of the Declaratio n of Truths that is...
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Grant unto thy Church, we beseech Thee, O merciful God, that She, being gathered together by the Holy Ghost, may be in no wise troubled by attack from her foes. O God, who by sin art offended and by penance pacified, mercifully regard the prayers of Thy people making supplication unto Thee,and turn away the scourges of Thine anger which we deserve for our sins. Almighty and Everlasting God, in whose Hand are the power and the government of every realm: look down upon and help the Christian people that the heathen nations who trust in the fierceness of their own might may be crushed by the power of thine Arm. Through our Lord Jesus Christ, Thy Son, who liveth and reigneth with Thee in the unity of the Holy Ghost, God, world without end. R. Amen.
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Tag Archives: repentance
A warning from recent history about changes to the CDF and notes about authentic and deficient "evangelization"
A priest friend sent this around to a select group. I think more people should know about it. As we read about the proposed Curial "reforms" Ottaviani reminds us that the seeds for this were sown by Paul VI another … Continue reading
Posted in The Coming Storm, The Drill Tagged Card. Ottaviani, CDF, evangelization, forgiveness of sins, Holy Office, Luke 24, New Evangelization, repentance 13 Comments


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Public drunkenness LOWER POTTSGROVE - Wendy Hennessey, 43, of Lower Pottsgrove was cited for public drunkenness on Feb. 16 at 12:37 p.m., after she was observed staggering in and out of the Turkey Hill on the 3000 block of East High Street, police said.
Witnesses told police they saw Hennessey trying to leave in a truck, police said.
Her blood-alcohol content was .315 percent, she was issued a citation and released to a sober adult, police said.
Harassment incident TRAPPE - State police are looking for man who allegedly harassed a 34-year-old Collegeville woman on Feb. 6 between 3:30 and 6 p.m., police said. The investigation is ongoing according to a report.
Homeowner hit opening door PERKIOMEN - State police are investigating a report of harassment that occurred on Feb. 8 at 5:25 a.m.
A 74-year-old woman hit a 48-year-old Schwenksville man in the face after he answered his own door on the first block of Highland Manor Drive, police said.
The investigation is ongoing according to a report.
Stolen chips UPPER MERION - A 54-year-old Collegeville man allegedly took seven $25 chips off a gaming table at the Valley Forge Casino on Feb. 8 at 6:33 p.m., state police said.
He stole the chips while the 42-year-old victim left them unattended, police said.
The man was found and paid restitution, police said. The victim did not press charges, according to police.
The suspect was permanently evicted from the casino, police said.
Drug charges SOUTH COVENTRY - A 17-year-old Pottstown resident was charged with drug possession on Jan. 10, at 9:53 a.m., state police said.
The incident happened in the 900 block of Ridge Road, police said.
Car crashes into guardrail SOUTH COVENTRY - A one-vehicle crash occurred on Jan. 8 on Ridge Road west of Daisy Point Road at 3:03 p.m., police said.
Geraldine T. Roussey, 62, of Stowe was traveling east on Route 23 when she veered off the right side of the roadway and up onto the guard rail, police said.
The car continued to travel approximately 50 more feet, and came to a stop still centered on the guard rail, according to police.
Roussey suffered minor injuries and she was wearing her seatbelt, police said.
Unpaid meal SKIPPACK - Linda Marie Ochuhida,44, of Skippack, was charged with public drunkenness and theft after she didn't pay for her meal at Park Bistro Restaurant, police said. On Feb. 5 at 6:32 p.m., Ochuhida left the restaurant without paying and was found intoxicated in the parking lot, police said. Charges were filed with District Judge Albert J. Augustine, the report said.
Royersford man charged with assault
WORCESTER - Marcus Edwin Morales, 27, of Royersford is being charged with harassment after two East Norriton women told state police Morales hit them in the face, police said. The two women told police that the incident happened during a verbal argument on Feb. 5 at 12:21 a.m., according to police.
Charges were filed with District Judge Albert J. Augustine, the report said.
Lansdale man charged with DUI
WORCESTER - A 26-year-old Lansdale man is suspected of driving under the influence after state police pulled his 2001 tan Ford Taurus over on Bustard Road on Feb. 3 at 11:33 p.m., police said.
The man exhibited signs of being under the influence of alcohol or a controlled substance and he failed to complete a standard field-sobriety test, police said.
He was taken into custody for DUI and charges are pending upon receipt of blood results, police said.
Public drunkenness SKIPPACK - John Thomas Ohara III of Schweksville was charged with public drunkenness after he was found lying in the roadway, police said. On Feb. 3 at 6:34 p.m., police found Ohara outside the Dutch Cottage Tavern on the 1200 block of Bridge Road.
Drug possession SKIPPACK - Morgan Taylor Carter, 19, of Williamsport was charged with drug possession on Feb. 3 at 9:59 a.m., police said.
The Pennsylvania Department of Corrections Drug Interdiction Unit found Carter with a large amount of crack cocaine, police said.
Charges have been filed with District Judge Albert J. Augustine.
DUI crash TRAPPE - Kimberly A Welch, 41, of Gilbertsville was charged with driving under the influence after she crashed into a PECO electric pole, police said. Welch was talking on her cell phone and driving west on Main Street and Fifth Avenue when she failed to pay attention to the road on Jan. 18 at 11:51 p.m., police said
She was not wearing her seatbelt and suffered minor injuries, the report said. She was treated at Phoenixville Hospital, police said.
HONEY BROOK - Gregory A. Naugle, 23, of Birdsboro was not injured after his Dodge Ram crashed into a utility pole on Poplar Road, police said. Naugle was driving south when he lost control of the truck, fishtailed across both lanes of traffic and off the eastern edge of the road on Feb. 11 at 4:55 a.m., police said. He was wearing his seatbelt and was not injured, police said. Naugle was cited for speeding.


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The latest edition of Doctor Who Adventures is out now:
Don't miss this week's issue of Doctor Who Adventures – we've got some top information on the TARDIS as we take an EXCLUSIVE look at its new-look control console! We love the new-look TARDIS, but we want to hear what you think of it. Email us and give us your thoughts!
Also this issue:
Also this issue:
- Monster TV: We reveal the best Monster Television shows. Do you know what your fave aliens love to watch on the box?
- Dr. Simeon Facts! Get the data on this bad doctor! We've got the lowdown on this cold-hearted villain and his cruel plans!
- Matt Smith and Jenna-Louise Coleman interview
- How a Silurian is made
- Mystery Gift! This week's issue comes with a mystery gift. Everybody loves a surprise. Well, not Sontarans, but nearly everyone else!