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ESMO @ ECC 2013: Premenopausal High-Risk Breast Cancer Patients with Luminal A Tumours Benefit from Postmastectomy Radiation
Findings from two small independent randomised trials suggest adjuvant radiotherapy should not be omitted in young patients with high-risk tumours.
- Date: 28 Sep 2013
- Topic: Breast cancer
The PAM50 assay was used to identify a subgroup of patients with node positive breast cancer who derived increased long term benefit from chemotherapy plus radiation over chemotherapy alone following mastectomy; premenopausal women with luminal A tumours showed significantly decreased local disease recurrence from the addition of radiation to chemotherapy following surgery in an analysis of long term follow-up data from two small independent studies.
Findings were presented on 28 September during the Breast Cancer/Advanced Disease segment of the Proffered Papers Session (Abstract E17-1573) at the 17th ECCO – 38th ESMO – 32nd ESTRO European Cancer Congress in Amsterdam, The Netherlands. The Congress was held from the 27 September through the 1 October, 2013 and was part of a series of European Cancer Congresses that are organised in joint partnership with ESSO, EACR, EONS and SIOPE to offer multidisciplinary and multi-professional educational opportunities in oncology.
The study presented by Dr. Laurberg and colleagues investigated the benefit from post-mastectomy radiotherapy (PMRT) based on biological subtypes defined by PAM50 in premenopausal women with node positive primary breast cancer, who participated in two studies investigating the effect of PMRT in addition to CMF back in the 90s.
A total of 128 FFPE samples and 87 fresh frozen samples were available for testing. The investigators observed an additional benefit for improved local-recurrence free survival (LRFS) by PMRT for women with Luminal A tumours in both cohorts but not in any other subtype, although in the British Columbia study PMRT also significantly increased LRFS in triple-negative breast cancer from 25% to 92%.
While this is a very interesting study using modern gene expression techniques, based on two large, prospectively randomised phase III trials with a 20 year follow-up, this study has a number of pitfalls which needs to be addressed. First of all, the main criticism remains that women only received CMF chemotherapy, which is today no longer the standard for node-positive breast cancer. Other points are the small number of women with tumour material for PAM50 assessment. In addition to that the number of events on which the results are based on within the subgroups become really small (1/6). This makes is really difficult to draw a conclusion. In addition such a small number of patients will never be able to show any effect on overall survival.
Having said that, I still believe this is an interesting study to build upon and try to identify young women who benefit from PMRT. Actual recommendations support PMRT in very young women with additional risk factors. However, we know in young women the risk profile is probably different from others and they might benefit from additional therapy even if they have a Luminal A tumour. But this warrants further investigations.
*Sibylle Loibl, ESMO spokeperson who was not involved in the study
A substantial risk for late loco-regional relapses in patients with luminal A breast cancers
Luminal A tumours are a double edged sword: While they are associated with a good prognosis they also carry a substantial risk for late loco-regional relapses. Tinne Laurberg of the Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark headed a team in conducting an analysis of data after 20 years of follow-up from two independent, similarly designed randomised trials to determine whether intrinsic subtypes identified by PAM50 classification could be predictive of long term loco-regional relapse after adjuvant radiation therapy was administered to preenopausal women following mastectomy.
The analysis was done only on data where accompanying biological samples were available from participants in either of the postmastectomy randomised adjuvant radiation trials conducted by the British Columbia Cancer Agency [Ragaz et al.NEJM 1997 Oct 2; 337(14):956-62]and the Danish Breast Cancer Cooperative Group (DBCG 82b) [Overgaardet al. NEJM 1997 Oct 2; 337:949-955].
The team performed gene expression profiles using the Nanostring Counter® on 128 formalin fixed paraffin embedded (FFPE) tissues that were available from the British Columbia (BC) trial and the Human Genome Survey Microarray version 2.0 (Applied Biosystem) for the 87 fresh frozen (FF) samples from the Danish Breast Cancer Cooperative Group (DBCCG). Each tumour was classified into Luminal A (LumA), Luminal B (LumB), Her2-enriched (Her2-E), Basal-like (BLBC) and Normal-like subtypes according to the PAM50 assay.
The differences per subtype in local-regional relapse free survival (LRFS) and overall survival (OS) were determined by Kaplan-Meier analysis and the log-rank test.
All patients had node positive breast cancer. Following mastectomy patients in both trials received adjuvant cyclophosphamide, methotrexate, fluorouracil (CMF) chemotherapy and were randomised to receive either radiation therapy (RT) that entailed irradiation of the chest wall and regional lymph nodes or no RT. The BC trial had a second randomisation; patients with estrogen receptor positive tumour were randomised to receive oophorectomy and data from 42 of these patients were included in this correlative study.
Radiation should not be omitted in young patients with high-risk tumours
The 20 year LRFSrate evaluated according to subtypes showed that women with LumA tumours who received postmastectomy radiotherapy had a significantly better LRFS; of 41 women with LumA tumours participating in the BC trial, 94% of women who received adjuvant radiotherapy had no local recurrence compared to 66% of women who received chemotherapy only (p = 0.05). Similar results were seen in the 20 women with LumA tumours in the DBCG trial where 92% of women in the radiotherapy group had no local recurrence compared to just 25% of women who received only chemotherapy (p = 0.01).
No statistically significant differences were observed for LRFS for LumB and Her2-E subtypes in either trial. However, in woman with BLBC subtype, 92% of women receiving radiotherapy compared to 23% in the chemotherapy only group achieved LRFS in the BC trial (p = 0.004); the rates for LRFS for BLBC were similar between treatment groups in the DBCG trial.
This analysis found no differences in OS between the tumour subgroups in either trial. However, findings from the DBCG trial showed OS was increased at a 10 year follow-up in the entire population with radiotherapy plus chemotherapy over chemotherapy alone: 54% of adjuvant radiotherapy patients versus 45% of chemotherapy alone were alive at 10 years (p < 0.001).
These results suggest that PAM50 Luminal A classification identifies patients with slow growing tumours who may obtain the greatest benefit from regional radiotherapy following mastectomy. The clinical implication is that radiation should not be omitted in young premenopausal patients with high-risk tumours.
The investigators reported no conflicts of interest.


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Professor Edemariam Tsega, grew up in Gondar, Ethiopia, and trained as a physician at McGill University in Montreal, Canada. In 1971 he returned to Addis Ababa to work. Professor Edemariam was instrumental in establishing the first Ethiopian post-graduate programme in Internal Medicine, which went on to train many of the current generation of physicians practicing there. He was Professor of Medicine, and subsequently Dean, of the Faculty of Medicine of Addis Ababa University. After his return to Canada in 1994, he practiced and taught Internal Medicine in central Newfoundland, and subsequently at McMaster University in Hamilton, Ontario.
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Between this morning's Acreage and Grain Stocks reports, the U.S. corn supply for the 2011-12 corn year is close to 0.5 billion bushels higher than the industry anticipated.
First, corn stocks in all positions as of June 1, 2011, totaled 3.67 billion bushels, down 15 percent from a year earlier. On-farm stocks at 1.68 billion bushels fell 21 percent from a year earlier, while off-farm stocks, at 1.99 billion bushels, are 9 percent lower. Grain stocks, however, were well above the average trade estimate of 3.3 billion bushels. "The big shocks are in the corn numbers," says James Bower, Bower Trading, Lafayette, Ind.
Soybean stocks of 619 million bushels and wheat stocks of 861 million bushels were also well above expectations of 596 million bushels and 826 million bushels, respectively. "What that shows is that feed demand backed off this spring when prices were high, especially for cattle producers," says Chad Hart, agricultural economist with Iowa State University. "Producers likely turned to unique alternative feed sources such as processed feed, byproducts, and bakery waste. They were searching for any alternative feed source."
Projected corn acres of 92.3 million will also send shock waves through the market. Projected acreage is 5 percent stronger than last year and the second highest planted acreage since 1944, behind only 2007's 93.5 million acres. Growers expect to harvest 84.9 million acres for grain, an increase of 4 percent from last year. The average trade estimate for corn acres was 90.8 million.
"I'm sure the report is a disappointment to corn bulls," says Bower. "It shows us that in the Northern Hemisphere if the producer gets an opening, he or she has the horse power to make up (planting delays) in a big way." According to the Acreage report, even with this year's significant planting delays, U.S. producers planted 1.6 million more acres than they indicated in the March Prospective Plantings report.
"The markets will focus on the corn numbers, which are bearish," says Bower. Without weather problems during the critical upcoming pollination period, which Bower expects to run from about July 11 to August 14 this year, December corn futures could fall to as low as $5.50 or $5.40, given today's bearish numbers, he says.
"If you go through the report on a state-by-state basis, you can see the impact of (planting-season) weather on some states and how other states compensated for that," says Hart. For instance, Illinois, Ohio, South Dakota, and North Dakota all lost acreage, while Iowa, Nebraska, and Minnesota gained acres.
The additional corn acres also came at the expense of soybean acreage. "Producers gave up beans and planted corn later than they normally would have in a more typical year," Hart says. "Prices favored corn this spring and producers responded." USDA pegged soybean planted acres at 75.2 million acres, down 3 percent from last year.
Yield will be a concern in many states moving forward, including Minnesota, North Dakota, and South Dakota, but other states like Iowa, where producers planted an additional 200,000 acres, and Nebraska could make up for yield losses elsewhere. "Minnesota corn got in, but it isn't necessarily in the best condition," says Hart, who will be revising his price forecast lower in the wake of today's reports.
"The wildcard is the 500,000 added acres in Nebraska," Hart says. "How much of it was planted in the (now-flooded) Missouri River valley?"


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1 May 2004Shaun and Hooky (and Vini) on one
If that's not your scene and maybe you're in the Midlands then why not get down to the Shrewsbury Buttermarket for the latest gig by new rock gods (shurely shome mishtake, Ed) The Durutti Column.
Labels: Happy_Mondays, New_Order, Peter_Hook, Shaun_Ryder, The_Durutti_Column
- May 1980 release schedule
- hallowed articles
- FAC 148 letter from Quarry Bank Mill to Tony Wilson
- FAC 81 stationery source materials
- FAC 81 stationery
- 86 Palatine Road Blue Plaque
- Joy Divison USA Tour Itinerary
- Tony Wilson letter to Ralph Steadman re John Dowie
- IKON stationery
- The Factory stationery
- In the City badge
- Peter Saville Associates stationery and bill
- Movement of the 24th January stationery
In the grey days of late 1970s post-punk Manchester, youth culture was a serious affair: every musical performance was measured mostly by the conviction of its delivery. The term 'New Wave' opened up free vistas where acquired skills could once again be exercised after punk's monochrome blur. It could be applied to anything from a James 'Blood' Ulmer record to the latest Throbbing Gristle release, Magazine to Swell Maps. Move outside that terrain into Sun Ra, Parliament, Frank Sinatra and Martin Denny, and your options were suddenly without limit...
Then came Tony Wilson's Factory Club (at the Russell Club in Hulme) offering an open invitation to experiment that was taken up when Ken Hollings, Howard Walmsley, Eddie Sherwood and a few others decided to make some noise to accompany their 16mm silent epic Biting Tongues. A further performance followed a few weeks later, when Colin Seddon and Graham Massey disbanded their Post Natals project and joined up. The film itself, a flashing series of negative images, became a memory; the name remained.
- extract from the LTM Biting Tongues biography
FAC 134 Trouble Hand
FAC 188 Compressor
IKON 26 Wall Of Surf
IKON 31 'Wall of Surf' T-SHIRT
IKON 45 'Wall of Surf' POSTER


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7 April 2014 at 3.01pm | Comment on this article
The winners of this year's Fanfare Competition have been announced. The competition, which invited young composers aged 11–16 to compose and record a short and attention-grabbing piece of music, attracted a record number of 260 entries.
The winners will now attend workshops at the Royal Opera House and have their compositions orchestrated and recorded by the Orchestra of the Royal Opera House. Audiences at the ROH will then hear the fanfares before performances to let them know that it's time to take their seats.
The judging panel comprised Music Director Antonio Pappano, Music Director of The Royal Ballet Barry Wordsworth and composers Kerry Andrew and Duncan Chapman.
'The standard of entries this year was really high this year and there were some wonderful and adventurous ideas that will make arresting and stunning fanfares', says Duncan. 'After much deliberation, we have selected a wonderfully diverse set of pieces.'
You can listen to the winning entries below. The Fanfares will be recorded in the orchestra pit on 24 May. All ten fanfares will then be played to Covent Garden audiences for the first time at the matinee performance of La bohème on 19 July.
Watch the process of transforming a fanfare from a rough recording to a polished performance:
Fanfare is an annual competition, and the Royal Opera House supplies a wide range of resources to help students and their teachers prepare. Use our Fanfare resources to get ready for next year's competition.
Jack Griffiths, Kings House Richmond, Playa
Joshua Dreyer, Burgoyne Middle School, Sparta
Aliyah Vara / Zara Lawrence, Burgoyne Middle School, The Devil's Playground
Theo Bently Curtin, Exeter School, Fanfare for Dancing Giraffes
Tom Gibson, Cottenham Village College, The Emperor's Train
Morgan Overton, Oakham School, Hét
Martha Herring, Oakham School, HERRING
Willow Mickel, Queen Elizabeth's Grammar
Tobias Clarke, Queen Elizabeth's Grammar, Here Today, Gone Tomorrow!
Daniel Harding, Marling School, Birth of a New Generation


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The Borgen Project is an innovative, national campaign that is working to make poverty a focus of U.S. foreign policy. This is a 12-week, part-time, unpaid internship. The selected candidate will be able to work from home and set their own schedule, but must meet weekly deadlines. Articles submitted will appear on BORGEN Magazine or The Borgen Project Blog.
Key Responsibilities:
- Interview sources and research topics in-depth.
- Write one well-researched article per week.
- Communicate with editors and supervisors.
- Assist with fundraising. Create a personal fundraising campaign and meet targets.
- Attend national conference call and/or training every Monday at 4 - 5:30 PM PST.
Strong journalism writing skills. Must be able to work independently and meet deadlines with very little supervision. Experience writing for newspapers is helpful, but not required.
We'll work with your schedule.
2500 Campus RdHonolulu, HI 96822


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You can watch our Holiday Concert again. Just click here to watch online.
Spring Road Elementary
1191 County Road II
Neenah, WI 54956
(920) 751-6975
Fax: (920) 751-6911
View Map
Mascot: Roadrunner
School Colors: Red and White
Location & History: Spring Road School has a rich history, having been established around 1890 as a one-room brick schoolhouse. Our present school was built in 1936 with additions and upgrades added over the decades. In 1962 the school became part of the Neenah Joint School District. Three classrooms of every grade are taught at Spring Road Elementary. Safely protected from heavy traffic and noise, the school is conveniently situated off Highway 41. Our school often serves as a gathering point for Town of Menasha residents and their community organizations.
Grades served: Kindergarten through Grade 5
Enrollment: Approximately 385 students
School sequence: Elementary School - Spring Road
6th Grade Middle School - Horace Mann
7th & 8th Grade Middle School - Shattuck
High School - Neenah High School
Distinctive Academic Programs: Spring Road's outdoor classroom, a nature site on the school property, will help kids learn about the environment in an educational and fun way.
The "Our Past and Present Roadrunners" bulletin board at Spring Road honors the school's alumni and parents who are featured in the news in a positive way.
Spring Road students and staff are dedicated to balanced literacy reading and writing instruction.
Parental Involvement: The Spring Road parent organization is organized as a PTO (Parent Teacher Organization). The PTO funds special needs like playground equipment, technology for the classroom, extra supplies for teachers, the Arthur W. Prosek scholarships, fine arts activities, and field trips. Many parents volunteer to support various activities sponsored by our PTO.
Extra Curriculars: The Roadrunner Squad (5th graders who help with service projects around school) and Environmental Field Trips.
Copyright © 2019 Neenah Joint School District. All rights reserved. | Site Map | Contact | 410 South Commercial Street, Neenah, WI 54956-2527 | Phone:920-751-6800


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1.0 Micron Modular 650V Trench Insulated BCD Process Technology
XDH10 is X-FAB's dielectric trench insulated smart power technology. Main target applications are analog switch ICs, driver ICs for capacitive, inductive and resistive loads and EL/piezo driver ICs for applications using 220 V net supply. The typical breakdown voltage of the HV-DMOS devices is >350 V or >650 V. The modular process combines DMOS, bipolar and CMOS processing steps that are compatible with dielectric insulation to provide a wide variety of MOS and bipolar devices with different voltage levels within a dielectric bidirectional high voltage trench insulation on the same die. The 14 layer core process module is available for 650 V breakdown voltage of the HV-DMOS. This process module provides trench insulation, single level poly with thick gate oxide, and a third level metal with power metal.


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The Groninger Museum
The town's main draw is the excellent Groninger Museum, set on its own island on the southern edge of the centre, directly across from the train station. Aside from a very cool information lounge with computers and touch screens, the museum is mostly given over to temporary exhibitions and what you see really depends on when you're here. If you're lucky, a rare work by the seventeenth-century Dutch painter Carel Fabritius – Man in a Helmet (probably the museum's most prized possession) – will be on display, or Rubens' energetic Adoration of the Magi and Isaac Israëls' inviting Hoedenwinkel from a modest sample of Hague School paintings.
Most people, however, visit as much for the building itself as for what's inside, which consists of six pavilions, each designed in a highly individual style: think Gaudí on holiday in Miami, and you'll have some idea of the interior decor. Once inside, between the stylish café and museum shop, the striking mosaic stairwell sweeps downwards, depositing you among bulbous lemon-yellow pillars and pink walls, from where moat-level corridors head off to pavilions either side: east to Mendini, Mendini 1 and Coop Himmelb(l)au, west to Starck and De Ploeg.
De Ploeg and the Starck Pavilion
The museum's collection includes a number of works by the Expressionists of the Groningen De Ploeg school, housed in their own pavilion, a trapezium constructed from red bricks. The De Ploeg movement is characterized by intense colour contrasts, exaggerated shapes and depiction of landscapes – often of the countryside north of Groningen. As founding member Jan Altink put it: "There wasn't much going on in the way of art in Groningen, so I thought of cultivation and thus also of ploughing. Hence the name De Ploeg." As well as Altink, look out for the paintings of Jan Wiegers. Upstairs from De Ploeg, the Philippe Starck pavilion is a giant disc clad in aluminium plating and houses the museum's wonderful collection of Chinese and Japanese porcelain, beautifully displayed in circular glass cases, softened by gauzy drapes.
The Mendini Pavilions and Coop Himmelb(l)au
On the other side of the mosaic stairway, the Mendini pavilions are dedicated to temporary exhibitions, while a large concrete stairway links Mendini 1 to the final, and most controversial, pavilion. Designed by Wolfgang Prix and Helmut Swiczinsky, who together call themselves Coop Himmelb(l)au, it's a Deconstructivist experiment: double-plated steel and reinforced glass jut out at awkward angles, and skinny aerial walkways crisscross the exhibition space. It all feels – probably deliberately – half-built. Look out for the glass-walk holes, where the concrete floor stops and suddenly between your feet the canal gapes, two storeys below. This pavilion is also given over to temporary exhibitions.
The North and the Frisian Islands
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NEW YORK (TheStreet) -- On Friday, I published Einhorn's a Hustler and He Doesn't Understand or Care About Apple.Over the weekend, hedge fund manager David Einhorn sent me an email and we had what ended up a constructive exchange. I'm not going to kiss the guy's tail. As much as I enjoyed his dialogue with Einhorn, I don't buy Henry Blodget's repeated "You are vastly more sophisticated" and "way smarter than I am" act; that's a weak way to concede an argument. If you're not sophisticated or smart enough to make your case in the first place, then why make it? That's why I never got into the merits of Einhorn's preferred stock proposal. Frankly, I don't understand it well enough. At the same time, I feel strongly that Einhorn -- and others -- miss big when they demand that Apple ( AAPL - Get Report) (A) has a responsibility to return even more cash to shareholders and/or (B) needs to do something better with its cash. Apple has never acted merely for the sake of acting or because an MBA textbook prescribes that it should. But I humbly digress. There's one thing I wish I would have done differently in Friday's article. And, for the record, Einhorn put no pressure on me to say this; I'm doing it of my own accord because it's simply the right thing to do. In one of the emails we exchanged, Einhorn said this:
Hustling is what an energetic center fielder does to get a fly ball in the gap. A hustler is a con man, who operates on the edge of the law and at a minimum takes advantage of people.Well-stated. As a person who takes the not-so-subtle differences between words seriously -- and appreciates well-done rhetoric -- I value Einhorn's distinction. I agree with it. I'm always hustling, but I'm not a hustler. Although trading a few emails doesn't make us buds, I'm confident the same applies to Einhorn. I think he's a good guy.
I called him out. Einhorn responded. In this business, you can't ask for much more than that. If he considered himself too big -- or me too small -- for engagement, all I could do is continue to speculate about his motives.


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The advantages of rejuvenation at an early age
FAQs about facial plastic surgery … are you a good candidate?
Ask the Surgeon / Health Tip / What's New
Types of scars and how to minimize their visibility
Scars result any time the deeper layers of skin are cut or torn. The appearance of the scar is affected by many variables, such as the size and depth of a wound, the blood supply to the area, the thickness and color of your skin, and the direction of the scar. Whatever type of scar you have, chances are there is a procedure that can help make it smaller and less conspicuous. Each type of scar responds to a different facial plastic surgery technique.
Keloid. Keloids are thick, protrusive mounds of scar tissue and are often red or darker in color than the surrounding skin. Keloid scars result from an overproduction of collagen that grow beyond the margins of the original wound.
Injecting steroid medication directly into the scar tissue will reduce redness, itching, and burning. The steroid also stops collagen production, which may allow the scar to flatten and fade over time. If more revision is necessary, the scar tissue can also be excised and closed with one or more layers of stitches.
Hypertrophic Scars. Hypertrophic scars are thick, red, and raised, however, unlike keloids the scar remains within the boundaries of the original incision or wound.
You may start out with topical applications or steroid injections. If this does not seem effective, the scar can be improved surgically by repositioning the incision so it heals in a less visible pattern.
Contractures. Burns or other major injuries may form a scar that pulls the edges of the skin together, a process called contraction. The resulting contracture may affect the adjacent muscles and tendons, restricting normal movement.
Correcting a contracture usually involves cutting out the scar and replacing it with a skin graft or a flap. In some cases, a Z-plasty or W-plasty may be used. These two techniques depict the different ways to release a contracted scar – cuts that resemble a z shape or a w shape, depending on the severity of the scar.
Scars that are raised or bumpy may respond to a resurfacing technique. In laser resurfacing, the laser emits powerful bursts of high-intensity light that vaporize the scar tissue with little or no damage to surrounding areas of the skin. Another option is dermabrasion (a facial sanding technique). On the other hand, if the scar is depressed, your physician may inject dermal fillers, such as collagen, to raise the scar.
Make an appointment to discuss your options. In some cases, more than one treatment, or a combination of techniques, may be needed to attain the best results.
Although scars cannot be eliminated entirely, modern techniques can minimize their visibility making it possible for disfiguring scarring to achieve a normal appearance.


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When the Ark of the Tabernacle was build by the Children of Israel to house the Tablets of the law (the Ten Commandments) God also instructed his servant Moses to "fashion a breastplate for making decisions - the work of skilled craftsmen".
This breastplate, made of purest gold and containing four rows of three precious stones each, was meant to represent the Twelve Tribes of Israel; each tribe noted by the particular color of the stone, which was derived from the flag or banner of each tribe.
Read More
Choshen Breastplate Of Aaron The High Priest
Posted in Jewish Gifts By Tom


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New 2019 DodgeDurango R/T AWD Sport Utility
- Stock: 7728
- Fuel Economy
- 14.0/22.0 mpg City/Hwy
- Exterior Color
- Billet
- Interior Color
- Black
- Body/Seating
- Sport Utility/7 seats
- Transmission
- 8 speed automatic
- Drivetrain
- all-wheel drive
- Engine
- 5.7-Liter V8 HEMI MDS VVT Engine
Highlighted Features
- Navigation system
- Entertainment system
- Blind spot sensor
- Lane departure
- Distance pacing cruise control
- Leather upholstery
- Automatic temperature control
- Emergency communication system
Standard Specifications
Vehicle Located At:
1109 South Monticello St
Directions Winamac, IN 46996
- Sales: (574) 200-0998
- Service: (574) 400-8650
- Parts: (574) 205-0444
KBB.com Consumer Reviews
- 5.0
By jason on Friday, January 13, 2012Purchased 2011 Citadel at end of model year and found a great deal. Prior to driving this automobile, Dodge/Jeep were at the bottom of my wish list. The vehicle is loaded with options. I could not find anything even close in other large SUVs for the price. Great for family with kids and for parents not ready for a minivan. Plenty of room even for adults in the 2nd and 3rd row seating. Entertainment system is very worthwhile for people with children. Much more comfortable ride than similar large SUVs. Safety features are wonderful. Only downside is it is a bit slow in accellerating from a stop (V6 engine). Not so much of an issue between 50-70 mph. Handles very well in winter weather as well.
- 5.0
Awesome truck with bad MPG
By spekgt on Monday, December 18, 2017Awesome truck with a lot of space , very powerful motor for whatever you need with a really sport and luxury interior and best of all with a great looking. So far a very reliable SUV ( Water pump replacement at 40k miles under warranty)
- 5.0
By Deo on Saturday, May 25, 2019So far impressed with this suv, this is my first American made vehicle and I purchased extra warranty which I have not had any reason to use. I travel a lot and prefer driving this suv than to rent something else. Owned it for almost 5 years 86k miles on and still loving it.
* MSRP is the Manufacturer's Suggested Retail Price (MSRP) of the vehicle. It does not include any taxes, fees or other charges. Pricing and availability may vary based on a variety of factors, including options, dealer, specials, fees, and financing qualifications. Consult your dealer for actual price and complete details. Vehicles shown may have optional equipment at additional cost.
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Europe's Last Hope – Will Germany Step Up? : George Soros
18 August 2011. Time is running out for the eurozone. Unless a euro-bond regime of one kind or another can be reached, the euro will break down. As the EU's largest and best-rated economy, Germany has a critical role to play in Europe's future. But the Germans are not willing to accept any level of responsibility. Till the day they do, Europe is headed towards a breakdown of the euro that will precipitate a banking crisis beyond the control of global financial authorities.Read more


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As some of you know, I've been diagnosed with cancer (liver and brain), so I've been pretty busy dealing with all the wonderful events related to my care and treatment. I'm giving it my best fight and trying to remain positive and lean on my faith in God. I've also had so much wonderful support from family and friends that has touched me deeply. Thank you to all of you! I love you so much.
Before I move onto my card, I would like to especially thank our good friend, Clair, who recently ran in a Relay for Life race that my other good friend, Jane, organized and dedicated to me. Here's Clair wearing a special shirt he had made. What a guy!!
Okay, so onto my card. Since I was feeling especially good today and had some available time, I decided to participate in the technique challenge over at Splitcoaststampers. We were to choose one of the first 50 technique challenges posted. I chose #9 - Crayon Resist - as it was one of my favorite techniques when I first began stamping. This is a very simple technique. I stamped my image onto Glossy White cardstock (you can also use Stampin' Up's Whisper White) and then used a white crayon to draw my lines/dots around the flowers and stems. The last step is to sponge ink over your image, wiping away the excess ink to reveal the white crayon resist.
If you did stop by, thanks and let me know that you did. I hope you're having a grand day.


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Hi and welcome to my web site. What you'll find here are the following:
Biography: If you're looking for a summary of facts about my career for a report, publicity or the like, this is it.
Books: Some think of me as a writer of children's books, while others know me for the adult books. I think of myself as simply a writer. So, I have listed books in the order in which they were published since the books written primarily for children and those written primarily for adults are parts of a whole.
FAQ: Here is where you'll find answers to questions I am asked a lot.
At present I am enjoying staying at home and am not accepting invitations to do school visits. Also I am not accepting lecture invitations that involve extensive travel.
If there's anything you'd like to see that's not here, or if you have questions not answered here, or something you want to tell me, I'd like to listen and you can reach me at


text: The filter on the System One milking machine filters air coming from the tank into the pump. As a normal part of the milking process, tiny bits of dirt, dust, even metal shavings can circulate through the system, and the filter traps these. Our filter consists of a small mesh screen and a piece of folded cheese-cloth. As part of your routine maintenance, open your filter and check the cleanliness of the cloth once a month. Replace the cheese-cloth as needed, and be sure to put the screen and cheesecloth back in the filter exactly as you found it.


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Job Information
Schneider National, Inc. Driver - Regional LTL Driver - E-Commerce Freight - Class A CDL in Beaverton, Oregon
Regional Less-Than-Truckload (LTL) truck drivers get home multiple times a week and earn up to $0.47 per mile* starting pay. Enjoy a predictable work schedule in this CDL driving job, averaging 1,800 miles per week. Regional LTL drivers assist with tailgating over-dimensional freight (furniture, carpet, etc.). As a Regional LTL trucker, you'll enjoy the best of both worlds: the freedom of the open road while staying close to home. Start your Regional LTL trucking career with Schneider's Dedicated division today in Portland!
Eligible CDL Truck Driver Applicants: All Class A CDL holders
Portland Regional LTL Driver Pay
Up to $70,000 per year*
$4,000 sign-on bonus for experienced drivers
$500 sign-on bonus for inexperienced drivers
Eligible for monthly safety and fuel bonuses
Stop-off pay and accessorial pay for breakdown, layover and load/unload
*Based on CDL driver experience, performance and location
Regional LTL Driver Benefits
Medical, dental and vision insurance, plus flexible spending options
401(k) savings plan with company match
Paid orientation and time off
Up to $7,000 tuition reimbursement (paid at $200/month) for qualified drivers
Credit for Military Experience program
Portland Regional LTL Driver Qualifications
Valid Class A Commercial Driver's License (CDL)
Live within 50 miles of Portland, OR
More Reasons to Choose Regional LTL Driving at Schneider
An industry-leading, year-round freight base with over 30 Dedicated LTL terminals
24/7/365 operations and maintenance support
Technology to increase driver productivity, locate equipment, expedite access and more
No employment contract - we don't lock you in, but you'll want to stay
Nationwide facility network, many locations offering free showers, laundry, WiFi, exercise equipment, TV lounges, cafeterias and more
Learn more about LTL driving
Why Schneider?
Schneider means what it says, and we have since 1935. We're a proven industry leader offering a huge variety of driving opportunities to help you become the best driver you can be - and living out our core values every step of the way: Safety, Integrity, Respect and Excellence.
"After working for several little companies, I've been with Schneider for 17 years because Schneider means what it says." John, Schneider driver
Join one of the top trucking companies in Oregon. Call 800-447-7433 for more information about becoming a Regional LTL truck driver with Schneider!
Schneider uses E-Verify to confirm the employment eligibility of all newly hired associates. To learn more about E-Verify, including your rights and responsibilities, please visit www.dhs.gov/E-Verify.
Job Company DriverSchedule Full-timeSign On Bonus 4000


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Could people recommend resources to help my wife learn more complicated mathematics? She had a really terrible maths education, and while she essentially OK with every day maths she keeps wanting to know more about topics that would be college and university level.
She often wants to dig much deeper into a subject than basic texts allow, but there are some fundamentals that she has never been taught, which means there is quite a lot of going back to basics needed.
I can find a lot of resources for remedial mathematics that are aimed at basic numeracy, but the questions she wants to ask are things like: What is set theory(which led us into questions on what numbers mean, and Peano axioms), How does cryptography work? What are imaginary numbers? Various stats problems.
I've got a maths and comp sci degree so I usually know what the answer is, but there is such a void of knowledge between us, we can spend hours getting deeper and deeper trying to resolve a side issue from the main question, and it can get frustrating for both of us. :)
General resources would be great, or advice on how best to approach it. Specific resources about Crypto, number/set theory, and Statistics would also be appreciated.