text:
Welcome to the Study Abroad & Higher Education Forums.
Get to know and share different aspects of civil services exam preparation. You can post and answer threads and posts in various sub-forums meant for the preparation of civil services examination.
Explore the forum, share your experiences of appearing/cracking engineering entrance exams and get to know its different aspects. You can ask questions and answer others queries by posting new threads.
This forum exclusively covers all related and relevant threads and posts on question papers, preparation tips, magazines, guide books, coaching centers and what not of all science courses.Get to know from others and also share all your experiences by posting and answering threads and posts.
Go through the forum to post new threads and answer the queries. Know everything related to courses, preparations, guidance, institutes, and exams and much more about mass communication career in India, in this forum.
Partake in dialogues on journalism as a career option and also take part in mutual discussions about the various entrance exams for it and preparation tips in this forum for journalism. Posts relevant posts and threads and get the dialogues rolling between you and other aspiring journalists.
Check out this forum, which is exclusively meant for medical science aspirants. Share anything you want to know about medial science entrance exams and career by posting new threads and replying threads.
Involve yourself in academic discussions on various aspects of healthcare services be it previous years question papers, or preparation tips, or magazines, guide books, coaching centers and anything else. So go ahead and post relevant posts and threads and reply to queries of other people as well.
This forum will provide all the information you want to know about MBA, such as entrance exam preparation, coaching centers, guidance/guide books and magazines, entrance tests and their dates, etc. You may post new threads as well as answer the existing ones, here.
This forum is specially designed to let you share information with others about different aspects of education and career in banking and finance industry, such as bank exams, question papers, guide books, coaching centers etc.
One can discuss and participate on issues like admission process, exam schedule, entrance exams, previous years questions papers, exam results and other topics related to University of Delhi.
Discuss about admissions, courses/programmes, exam schedules, results and entrance exams at IGNOU, one of the most popular universities in India.
This forum on Mumbai University offers a platform to discuss and share experiences on various aspects such as exams, schedules, distance & open learning, courses and results.
In Arts & Social Science forum, you can discuss about career options, courses, colleges, institutes, entrance exams and results.
This forum on law is aimed at facilitating discussions on career options, higher studies, entrance exams, syllabus, course structure, exam schedules, results and other such topics related to law.
Post threads and posts on your queries, views, concerns and opinions on teaching skills, knowledge, attitude, career options and entrance tests in this forum for education. By doing so you can share your very own individual know-how and also learn from others experience.
In this forum, you can clear all your queries regarding higher education in UK. You may post new threads, reply to the existing ones and discuss about the popular courses, top colleges and their contact details, and the top universities to study in UK.
Post away your worries on study abroad examinations by posting threads and posts in this forum. This forum has been specially designed so that you can post away your study abroad entrance exam blues and preparation doubts.
Explore this forum to discuss about studying in USA. Here, you can start new threads, reply to the existing ones, and post your queries about the top colleges and universities, courses offered and facilities in the educational institutions, to study in USA.
This forum provides you a platform to discuss about higher education in Canada. Here, you can start new threads and post replies about the top colleges and universities and the popular courses to study in Canada.
Through this forum, you can clear all your doubts about what to do for studying in New Zealand. You can discuss about various colleges, their facilities, courses and contact details of the universities, to study in New Zealand.
Go through this forum to clear all your doubts about studying in Australia. Here, you can discuss about the top colleges and universities in Australia, courses offered, by posting new threads. You can clarify others queries as well, by replying to the existing threads.
Drive away all your dilemmas related to career selection and planning related to fashion and textile industry by posting threads and posts in this forum.
In this forum on accessory design take part in exchange of ideas and experience with other aspirants by posting threads and posts and also replying to others queries. So start posting and get to know all aspects about accessory design as a career.
Partake in discussions on how, why, when and where of internship and internship projects ideas. So start posting your queries, views or ideas in this forum now to open a whole new world of possibilities.
This forum exclusively deals with projects in different streams like engineering, MBA etc. Explore this forum and get to know, share and ideate on different project ideas.
This forum gives you a platform to clear your doubts and partake in discussions on seminar topics.
This forum exclusively deals with dissertation or thesis topics . Take part in discussions to express your dilemmas or views on the same.

subset: commoncrawl


text:
As part of our image quality testing for the Olympus SP-620UZ, we've shot our resolution chart.
If you view our crops of the resolution chart's central section at 100% (or Actual Pixels) you will see that, for example, at ISO 100 the Olympus SP-620UZ is capable of resolving up to around 20 (line widths per picture height x100) in its highest quality JPEG files.
Examining images of the chart taken at each sensitivity setting reveals the following resolution scores in line widths per picture height x100:
ISO 80, score: 22 (see full image)
ISO 100, score: 20 (see full image)
ISO 200, score: 20 (see full image)
ISO 400, score: 18 (see full image)
ISO 800, score: 16 (see full image)
ISO 1600, score: 12 (see full image)
Follow this link for a full explanation of what our resolution charts mean.


text:
Login to Admin Console
From the Common Task screen select the configuration from the drop-down list and click Edit Configurations tab.
Click the Access Control tab in the configuration screen.
Click the Access Control Lists (ACL) tab in the Authentication Databases screen.
Click New to create an ACL.
The default access control list resides in the directory install_dir/admin-server/config. The default ACL file is default.acl.
With Web Server you can configure and reference multiple ACL files. For more information about configuring ACL files for virtual servers, see the Sun Java System Web Server 7.0 Update 3 Administrator's Guide.
You can use the Access Control API to manipulate ACLs, read and write ACL files, and evaluate and test access to resources on the server.
You can also define your own attributes for authentication. The following example shows how you could authenticate users based on an e-mail address or on the URL that referred them to the resource:
allow (read) referrer="*www.acme.com*"
You can also authenticate the client based on your own authentication methods and databases.


text:
Koach Soldjer was born in Baton Rouge Louisiana on August 14 1986. By 1993 he was already writing rap and rb songs. In 1995 along with neighborhood friend Marcus Moffett AKA Big Ham Soldjer started a rap group called Lil Con Mind Killaz. After meeting Kendrick Peanut Volter the three changed the name of the group to Pryme Tyme. However shortly after establishing the group Peanut was incarcerated and is still serving a 45 year sentence. Eventually Ham lost focus and is now also incarcerated serving a 35 year sentence. Koach Soldjer went forward with his brother Lil' Twist and three other friends Big Funz Sexy Red and Killa Red. In 1997 Koach Soldjer and Lil' Twist bumped into an old friend of their uncle's Big E. Big E was one of the CEO's of Lay 'Em Down Records a label produced by hit making producer Phunk Dawg of House of Phunk and now Phunk Dawg Exclusive (known now for Hurricane Chris' A Bay Bay and Hand Clap). They began doing shows with known artists such as Mystikal Tre-8 and Beelow (a local B.R. rapper/ business man) just to name a few.
When things were no longer working out Koach Soldjer remembered someone Peanut had introduced him to before Peanut's incarceration Erik YT Fairly. Koach Soldjer YT and James JJ Lee (longtime friend of YT) started a new group called Military Ridahz and label Military Mynded Records. Lil' Twist (Koach Soldjer's brother) Young Chopper AKA Chopper Capone (from Lay 'Em Down Records) and Big Funz (former member of Pryme Tyme) also joined Military Ridahz. As a group they went on to win a talent show and begin travelling doing concerts and building their brand. They went from venue to venue appearing on tickets with Ruff Ryders Ashanti Ludacris Mystikal Juvenile Young Bleed Skull Duggrey Kane Abel T-Bo da Firecracker C-loc Max Minelli and South Coast Coalition. The Military Ridahz released their first album Military Ridahz: Young Raw Heated selling hundreds of copies locally.
The Military Ridahz were asked by South Coast Coalition to join them in their shows with T-Bo. Word of the Ridahz began to spread and they quickly became a success. Because of creative differences between Koach Soldjer and the CEO of Military Mynded Records Koach Soldjer decided to separate himself from the group. This is when he had the opportunity to become acquainted with Tiny Lister Jr. (AKA D-Bo) star of Friday The 5th Element and The Dark Knight (2008) among others. D-Bo made a promise that if Koach Soldjer helped him with saving the kids from urban crime areas then he would help push his music. The promise wasn't fulfilled so Koach Soldjer made another way. In 2007 he went to a friend he had met in 2000 Leon POOCH Dunn CEO of PRO Rated Productions LLC.
With PRO Rated Koach Soldjer (PRESIDENT/Co CEO of ProRated's Behind the Tint Ent..) has released an EP featuring former No Limit Records rappers Skull Duggrey and T-Bo Da Firecracker two of Baton Rouge's hottest local rappers Nussie (R.I.P) and Pla' Boy and other PRO Rated artists. He's traveled doing concerts and is now working on some of the biggest projects of his career as an utive producer and a writer. Koach Soldjer reconnected with some of the Military Ridahz now named Tha Ridahz Reloaded. He reunited with Phunk Dawg working on his early 2012 Re-release of pt.1 to The Welcome to Donkey Kong album part 1 2 with The Clan Behind the Rolls Tint His solo:Through the Red Tape featuring Fellow Artist/Label mate Pla'Boy Graham along with PRO Rated producers POOCHSpeedy Phil Mic. Koach Soldjer is also gearing up for the release of His Book The Dirt Skeleton G2:7 Project which was inspired by his DEATHLETTAH Song Iago's Album Pla' Boy's Spoil Rotten MixTape for 2012.


text:
April 17, 2004
The lightweight crew team reclaimed the Dodge Cup, which was held previously by Columbia, by defeating the Lions and the Penn Quakers on the Schuylkill River in Philadelphia. The Elis won three of four races in the regatta, with only the Novices not taking first.
In the Varsity race, the Bulldogs came in first with a time of 6:06.2, defeating Columbia (6:09.4) and Penn (6:10.6.) The Elis also sat atop the standings in the second Varsity race, handily defeating second-place Penn by nearly 10 seconds. Yale's time was 6:08.5, while Penn came in at 6:17.9 and Columbia finished in 6:21.8
The Elis' only non-first place race was in the Novice division, where Penn earned the top spot with a time of 6:09.4 and Yale came in second in 6:15.5. Columbia rowed to third place with a time of 6:30.6.
In the second frosh fours, the Elis won their third of four races by over 40 seconds, rowing to a 7:21 time that was well ahead of Columbia's 8:03.6.
The races were sailed in moderate chop, with building headwinds from 10-15 knots and an above normal tail current.
Yale will host a doubleheader including races against Dartmouth, Rutgers, and Cornell next Saturday in Derby.


text:
Sentinel Node procedure for DCIS
Dear OncoLink "Ask The Experts,"
I am 45 years old, I have DCIS. I am scheduled for a lumpectomy. I have two different opinions on the sentinel node procedure. I am very afraid of the side effects. Is there any benefit to this?
Kevin Fox, MD Assistant Director, Clinical Affairs and Associate Professor of Hematology/Oncology at the Abramson Cancer Center of the University of Pennsylvania, responds:
There is ongoing controversy regarding the sentinel node procedure in patients with DCIS. The policy at the Hospital of the University of Pennsylvania is that the sentinel node procedure should not be done in patients with DCIS because the risk of tumor spread to lymph nodes is extremely low. In the case of invasive carcinoma, sentinel lymph node biopsy may be performed by surgeons trained in the procedure as an alternative to immediate axillary lymph node disection.


text:
This includes:
White Beekeeping Vest with hooded veil. Zipped hood with velcro zip guard. Light weight vest with elasticated waist and…
Ideal for those quick apiary visits when there is no need for a full beekeeping suit.
One size fits all…
Beekeeping Vest.
Wear under usual clothes or overalls. One size fits all.
Unzip and throw back hooded veil with velcro zip guard.
Thick close weave cotton drill ankle protectors, gaitors. Easy to put on over shoes for extra sting protection around the ankle.…


text:
M.R. James, an informal portrait
Oxford University Press, Jan 1, 1983 - Biography & Autobiography - 268 pages
From inside the book
6 pages matching Maisie in this book
Where's the rest of this book?
Results 1-3 of 6
What people are saying - Write a review
LibraryThing ReviewUser Review - JBD1 - LibraryThing
Since the biographies of M. R. James are fairly thin on the ground, we take what we can get, and Cox's effort is by no means a poor one. This is a slim but thorough biography of James, concentrating ... Read full review
Common terms and phrases
A. C. Benson amongst Arthur Benson Austen Leigh began boys Bradshaw called Cambridge catalogues Chapel Christmas Church Clive Carey Cockerell Cropper Cyril Alington death December Diary elected Eric Millar Eton and King's Eton College Etonian February feel Fitzwilliam friends friendship ghost stories Gordon Carey Gwendolen McBryde Henry Babington Smith Herbert James Hugh James McBryde James's January June Keynes King's College later letter Library Lionel Ford Livermere Lodge Luxmoore M. R. James Maisie manuscript March Memoir memory Montague Rhodes James Monty James Monty told Monty wrote MRJ to GMcB MRJ to HJ Nathaniel Wedd never November October Oppidan Oscar Browning perhaps Prothero Provost of King's provostship published rooms scholar seemed St Clair Donaldson Sydney Temple Grove things thought told Gwendolen took Trinity tutor undergraduates Vice-Provost Walter Durnford Walter Fletcher Waterfield window writing


text:
Carpet & Upholstery Wipes
Durable Wipe for Cleaning Spots and Stains on Fabric, Carpet and Floor Mats
- Cleans fabric seats and floor mats
- Gets out automotive dirt and grime
- Won't leave greasy residue on interior surfaces or hands
- Fits conveniently in your glove box or drink holder
Wipe soiled surface with Armor All® Carpet & Upholstery Wipes. Stubborn stains may require scrubbing. Wipe hands clean if needed. Dispose of wipes in trash. Do not flush.
12 ct.
Expert Tips FAQs Products Advisor
© 2019 The Armor All/STP Products Company.


text:
U.N. disinvites Iran to Syrian peace talks
AMMAN, Jordan — A long-awaited peace conference on Syria was in danger of falling apart Monday over Iran's refusal to pull its forces from the country and agree to a new government that wouldn't include dictator Bashar Assad.
The main Western-backed opposition group to Assad said Iran must commit publicly to withdraw its "troops and militias" from Syria and abide by a 2012 transitional road map pushed by the United States.
That road map calls for all foreign forces to get out of Syria and the creation of a transitional government with full executive powers without Assad, whose crackdown on political opponents is being backed by Iranian troops, supplies and advisers.
In an example of the pressure against Iran, United Nations Secretary-General Ban Ki Moon on Monday rescinded an invitation he made to Iran on Sunday to join the conference, the second such meeting scheduled to start Wednesday in Geneva. The U.S. State Department is trying to figure a way to keep the conference on schedule despite Iran's refusal to say whether it will end assistance to Assad.
The Syrian National Coalition, Syria's main opposition group, said it was "suspending" its participation in the conference until Iran agrees to the road map for peace.
"We consider Iran a country that is invading Syria and sending in militia, whether it's Revolutionary Guard or Hezbollah," said Ahmad Ramadan, a senior member of the organization, which is based in Istanbul. "If the situation does not change, the coalition will not be" at the talks, he said.
However, other members of the Syrian National Council said they may attend the talks to counter the perception that Assad is willing to talk peace but the rebels are not.
"The first impression is that there is no benefit from Geneva II, everybody thinks that," said Hisham Marwa, a member of the Syrian National Council in Damascus. "But the SNC participating in the conference is to prove that the regime is not being serious about it."
The Syrian National Council recently voted in favor of participating – with 58 members out of 119 voting to attend and 44 boycotting the vote. The U.N.-hosted peace talks were formed after months of political maneuvering to get to a table members of Assad's government and rebel representatives.
Assad has been pounding civilians and rebel fighters in a nearly three-year civil war in which well over 100,000 people have died and 8 million people have been forced from their homes, many of whom must live in refugee camps outside the border. Assad has said the rebels are merely terrorist groups seeking to take over the state.
The uprising grew out of peaceful demands for democratic reforms and turned violent only after Assad directed his army to attack cities where opposition to his dictatorship was strong. Now, there are several U.S.-designated terror groups fighting alongside rebels, and sometimes against them.
Ban says Iran has accepted new elections in Syria, but it has not said whether it agrees that Assad should be banned from the elections.
Iran has been supporting Assad's regime with billions of dollars in credit and weapons since the conflict erupted in March 2011. Analysts said even if a diplomatic solution is reached it could take some time before there's real change on the ground.
"We've seen over and over again how forces on the ground inside Syria evolve rapidly and independently," said Mona Yacoubian, a senior adviser for the Stimson Center's Middle East program, in Washington.
"That's what's scary about Syria, particularly how we're seeing this proliferation of extremist groups, the influx of foreign fighters — all of these dynamics on the ground really have a life of their own," said Yacoubian.
Some Syrians say there will be no peace until Assad's regime is removed one way or another.
"Forming an interim government with some of regime figures means reforming the regime and not having new one," said Suzan Ahmad, a student and anti-regime activist in Damascus. "How do you think Syrians will accept the same regime that killed and displaced them to rule them again?"


text:
Your browser does not support iframes.
Harriman's Jonathan Bowling weighed a two-day total of 10 bass totaling 28 pounds, 11 ounces to win the Walmart Bass Fishing League Volunteer Division super tournament recently held on Watts Bar Lake in Rockwood. For his victory, Bowling earned $4,540.
The Tennessee Wildlife Resources Agency has published The Angler's Guide to Tennessee Fish, a new identification guide on the vast variety of fish species in the state. The new guide is currently available at TWRA offices and online at TWRA's website www.tnwildlife.org
Mark Ventura, of the Tennessee Wildlife Resources Agency, has received the prestigious honor of being named as the Tennessee Southeastern Association of Fish and Wildlife Agencies (SEAFWA) Wildlife Officer of the Year. Ventura was presented the award during the 65rd Annual SEAFWA Conference that the TWRA hosted in Nashville.
The Tennessee Wildlife Resources Commission heard several topics concerning commercial fishing and also approved the 2012 sport fishing regulations among business at a recent meeting.
The Tennessee Wildlife Resources Agency has established a walleye stocking program in the Watts Bar Reservoir by recently releasing more than 220,000 fingerlings in the lake. The young walleye were raised at the Eagle Bend Fish Hatchery and were stocked in various locations around the reservoir to augment sauger stocking in Watts Bar.
Federal fish hatcheries responsible for raising 60 percent of all trout in Tennessee are in jeopardy due to proposed federal budget cuts. The cuts would become effective Oct. 11, 2011 and would eliminate a majority of the funding for the Dale Hollow National Fish Hatchery and the Erwin National Fish Hatchery.
Copyright © 2019
The Roane County News is your source for local news, sports, events, and information in Roane County and Kingston, Tennessee, and the surrounding area.


text:
The feedstocks prism
Unveiling value in volatile and complex petrochemicals
The feedstocks prism focuses on the road ahead for upstream feedstocks and energy, and examines ways in which the familiar historical platform for the world of chemistry, materials science, and industrial biology could change.
Deloitte Insights
Connected barrels: Transforming oil and gas strategies with the Internet of Things
In the oil and gas industry, the promise of IoT applications lies not with managing existing assets, supply chains, or customer relationships but, rather, in creating new value in information about these. An integrated deployment strategy is key for O&G companies looking to find value in IoT technology.


text:
The Old Shed
Exif: F Number: 8, Exposure Bias Value: 0.00, ExposureTime: 1/200 seconds, Flash: did not fire, compulsory flash mode, ISO: 100, White balance: Auto white balance, FocalLength: 28.00 mm, Model: Canon EOS 50D
Uploaded on August 24, 2010
Copyright for this gallery photo belongs solely to Jill Saurbaugh. Images may not be copied, downloaded, or used in any way without the expressed, written permission of the photographer. Contact photographer via gallery
Log in to follow or message this photographer or report this photo.


text:
Saving a million — for another county
Staff writer
When Evan Stout walks out of a room, he automatically shuts off the lights, even if it is a hallway at Marion County Road and Bridge staging office where he works, or the light over his oven at home in Marion.
"After eight years of working as an energy manager, it is just habit for me," Stout said. "I told my wife the other day, 'I don't think the oven is afraid of the dark. There is no reason for these extra lights to be on.'"
Stout works full-time for the county and part-time for Energy Education, Inc. (an energy savings company out of Wichita Falls, Texas). Two weeks ago, USD 418 McPherson schools honored him for saving the district a million dollars in energy costs.
"They had a little party complete with cake and ice cream," he said. "I really wish I had required a commission on what they saved, but it is all about cost avoidance."
Stout said that he traveled to McPherson just about every day for the past eight years after his regular job, constantly auditing district buildings and looking for common sense ways for the district to save money.
"Cost avoidance refers to money that they do not have to spend on electricity, sewer, water, and gas," he said. "I would recommend things like shutting down electricity in buildings that were empty overnight or on weekends, or help them set programmable thermostats properly."
Stout also said he advised the district's assistant superintendent to get a separate meter for watering systems to bring down overall payments made to the city for water usage.
"If the same meter is used for all of the water the district uses, they are paying sewer fees combined with that extra water used. That is just how it is billed," Stout said. "Ball diamonds and football fields don't need that combined water and sewer rate. It is the pennies saved that make dollars."
The energy company Stout works for offers energy auditing services only to large school districts, usually those classified as 5A or larger. He said USD 418 paid $40,000 for the service, along with his salary, but in return saved more than a million dollars over an eight-year period.
"I am more than willing to speak to any size school district and share my knowledge to help our communities," he said. "I am not out to grab money. I just see that school districts around here are being asked to really tighten their belts and I could help with energy savings audits."
Stout has traveled to energy education workshops in Dallas, Nashville, Chicago, San Antonio, and Oklahoma City in the past few years, staying on top of current energy savings tips and ideas.
"Most savings occur during what we call 'unoccupied time' in school buildings," he said. "Student bodies will raise the temperature of a building by five degrees. When they are gone, those thermostats need to be turned down."
Stout said his recommendations for large buildings were not the same as for personal homes, however.
"Most buildings will hold a comfortable temperature for several hours, and when they are unoccupied it is for longer periods of time," he said. "In homes, it is more cost effective, in the summer, to leave the air conditioner set at a certain level and not turn it off and on, for day and night or changes outdoors."
Stout said he has done energy audits at the Marion County Courthouse but many changes need to be made before they could see any savings on energy costs.
"There are problems with the windows, boilers, lighting, etcetera," he said. "But the commissioners continue to spend money elsewhere and energy savings are not high on the priority list."
Stout said he offered his services at St. Luke Hospital in Marion and to Centre and Hillsboro school district boards, but they had not followed up on his offer.
He recently did a walk-through for McPherson College and several churches in the city of McPherson, which resulted in several significant cost-saving measures.
Stout and his wife moved to Marion three years ago at which time he began full-time work on the county road and bridge crew. He has completed his contract with McPherson schools for energy savings.


text:
MLS Review: Sporting KC win again, Toronto held
MLS Cup champions Sporting are four points clear at the top of their conference after a 2-1 win over the Los Angeles Galaxy.
The win was their third straight in the league and extended their unbeaten run in MLS to six matches.
Benny Feilhaber opened the scoring in style in the 11th minute at Sporting Park, curling in a stunning 20-yard free kick.
In far less impressive fashion, Kansas City doubled their lead just after the hour-mark as Lawrence Olum headed in after a scramble in the area.
Robbie Keane gave his side hope when he beat the offside trap to finish, but the Western Conference's fourth-placed team were unable to find an equaliser.
DC United, who are second to Sporting, can close the gap when they host Chivas USA on Sunday.
Third-placed Toronto dropped points for the fifth time in six league games, needing to come from behind twice to draw 2-2 against the Houston Dynamo.
Will Bruin made it 1-0 to the Dynamo in the 11th minute, capitalising on a poor Bradley Orr back pass before rounding goalkeeper Joseph Bendik and tapping in.
Brazilian Gilberto found room in the area to level just seven minutes later before the Dynamo restored their lead.
Giles Barnes' powerful 25-yard strike found the bottom corner to make it 2-1 and Toronto should have been level just moments later, only for Michael Bradley to strike the post with a penalty.
Toronto would level just before half-time as Luke Moore set up Dominic Oduro to tap in, and that was the end of the scoring.
Elsewhere, MLS leading goalscorer Bradley Wright-Phillips scored a penalty as the New York Red Bulls drew 1-1 against the San Jose Earthquakes.
Bernardo Anor's second-half brace led the Columbus Crew to a 2-1 win over the Montreal Impact and Sebastien Le Toux's late penalty saw the Philadelphia Union draw 1-1 against the Chicago Fire.
Dallas were 2-0 winners over the New England Revolution and Real Salt Lake drew 1-1 against the Vancouver Whitecaps.


text:
"Fraud, Scams and ID Theft," a seminar by Amy Shuey, will be presented from 11 a.m. to 12:30 p.m. on Tuesday, June 18, in Foster Auditorium, 102 Paterno Library on the University Park campus of Penn State. The free seminar intended for Penn State students, faculty and staff will cover identity theft prevention tips and the newest fraud schemes and will discuss how to avoid being scammed.
Shuey has been the marketing and education coordinator at the Penn State Federal Credit Union since 2004. Along with her marketing duties, she teaches financial literacy to the Penn State community and to youth and adults in the Centre Region.
The program is sponsored by the William and Joan Schreyer Business Library in the University Libraries. For more information or if you anticipate needing accessibility accommodations or have questions about the physical access provided, contact Lauren Reiter at firstname.lastname@example.com or 814-865-4414.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
This letter is in response to the letter to the editor, "No Need to Bring up Previous Fatalities." I am Susan Hardin, mother of the late Elyse Rebecca Hardin. The car crash that took Elyse'slife has been mentioned in several articles since her death. I would first like to state that I speak only for our family. I would never be so disrespectful as to speak for the other families who have also lost a child. They continue to be in our thoughts and prayers daily.
If you currently subscribe or have subscribed in the past to the The Lancaster News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
|ZIP Code:


text:
Politics & Government
Rearview cameras to become standard equipment by 2018
The U.S. government said on Monday it will require new cars and light trucks sold in the United States to have rearview cameras by May 2018, a regulation intended to prevent drivers from backing into pedestrians.
The National Highway Traffic Safety Administration said the new requirement will apply to all vehicles under 10,000 pounds (4,500 kg), including buses and trucks.
"Rear visibility requirements will save lives, and will save many families from the heartache suffered after these tragic incidents occur," said NHTSA Acting Administrator David Friedman said in a statement.
There are, on average, 210 fatalities and 15,000 injuries per year caused by backover accidents, the agency said. Children under 5 years old and adults 70 and older account for more than half of all backover fatalities each year.
Many automakers already are installing rearview cameras in response to consumer demand.
The new rule will require that the field of view must include a 10-foot-by-20-foot (3-meter-by-6-meter) zone directly behind the vehicle, NHTSA said. The video system also must meet other requirements, including image size.
(Reporting by Eric Beech; Editing by Bill Trott)


text:
The sleekest in size, packed with power. An incredible, powerful camera and totally reimagined interface do more in less space, with a intelligent battery that's big enough to share.
Cinematic Infinity Display- A nearly frameless Cinematic Infinity Display for more detail and clarity, more immersive and uninterrupted content, in a slim, balanced form
Feature list:


text:
As negotiations between the town of Bluffton and a private landowner to allow for wetland restoration that would treat 4,900 acres remain stuck, officials are leaving the door open to clearing the way through eminent domain.
The town stresses that condemnation is a last resort, but efforts to secure an easement on 42.5 acres opposite Stoney Creek off S.C. 46 haven't proved successful, and the project is critical for efforts to restore water quality in the May River, Bluffton's stormwater management chief said at a planning session this month.
"I won't call it the 'silver bullet,' but it's critical," said Ron Bullman.
The project, which involves plugging or filling more than 5,700 feet of man-made ditches formed more than a century ago, would cost an estimated $500,000 in design and construction after securing an easement, according to a January 2012 report.
The ditches hinder the natural filtration process that should be reducing pollutant loads at station 19-19, the state monitoring post just south of Rose Dhu Creek that trigged the closure of a four-mile stretch of water to the west in 2010, Bullman said. A wetland restoration could remove 227 million units of pollutants annually in a 4,900-acre subwatershed that drains into a major bacteria "hotspot," he added.
That's about four times greater than any other project currently planned by the town, Bullman said.
"That drainage way, that wetland, drains roughly 50 percent of station 19-19, and so depending on how good of a project we could get in there and how efficient it would be would determine how much of that 50 percent we would treat," he said. "It's very rare to get a project that completes 100 percent of a 5,000-acre watershed, but even if we could get something that's 50-percent efficient, that's still 25 percent of station 19-19."
The ditches fall on a piece of land between Kenzie Park and the campground off S.C. 46 that can't be easily developed anyway, said Mayor Lisa Sulka, adding she's hopeful for support from Beaufort County, which has jurisdiction because the parcel is unincorporated.
"We have a whole new County Council, some fresh faces, and a lot of older council members who have never heard about this," she said.
The town has held informal conversations with County Council and county staff, hoping to eventually identify a representative in a formal meeting soon, Bullman said.
The town doesn't need county approval of an easement but could eventually have to go through Beaufort for permits once the project gets off the ground, and the county could provide added heft during the ongoing negotiations, Bullman added.
Bullman wouldn't answer questions about the sticking points in talks with the landowner, whom he asked not to be identified for fear of setting back negotiations.
"We are not at liberty to discuss details of active land acquisitions or negotiations," he said.
Nor would he say at what point the town would push to condemn.
Town attorney Terry Finger said at the strategic planning session this month that Bluffton could legally force an easement in the name of the public good.
"We could push the envelope and condemn land outside of our borders if it will have a direct effect on the health, safety and welfare of our town, and it is contiguous," he said. "That's an aggressive stance, but the law does allow it to happen."
County attorney Josh Gruber agreed.
"The town can actually condemn outside their legal limits," he said. "It's just usually a last-ditch effort."
The restoration is one of many projects included in a 2011 action plan containing some $40 million worth of ideas to address deteriorating water quality widely blamed on rapid commercial and residential development.
The town included $1.05 million in capital projects in its budget this fiscal year to start that list.
The Department of Health and Environmental Control reopened a half-mile stretch of river between Gascoigne Bluff and Linden Plantation Road to oyster harvesting in September. Officials took the move as a sign of progress but acknowledged that it wasn't clear those sections were ever impaired because the state shut down any area lacking the data to prove sufficient water quality, and monitoring stations for those sections came afterward.


text:
PORTLAND — It's called a victimless crime. The world's oldest profession. And promoting it is now defined as a form of human trafficking, under a state law signed July 11.
But for police and some city residents, prostitution in the city is simply a challenge of day-to-day life.
The problem made headlines again recently after a July 7 police sting operation in Parkside netted four arrests for engaging a prostitute. The arrests came less than two weeks after a similar operation resulted in two other "johns" being arrested in the same neighborhood after allegedly soliciting sex from an undercover police officer.
The incidents bring the total number of john arrests made so far in 2013 to eight, according to police data. That's equal to the number made during all of 2012.
"We are seeing more prostitutes on the street, even more than in 2012," Assistant Police Chief Vern Malloch said in an interview last Friday. "That brings out more johns."
While street-level prostitution hadn't been a significant problem in Portland for several years, according to Malloch, there's now a "resurgence."
And police don't know why.
Emphasis on Parkside
The increase seems to be most focused in Parkside, the area between Congress Street and Park Avenue bordered by Forest Avenue and St. John Street. Five of the six recent arrests were made in a two-block area along Weymouth Street, on the neighborhood's perimeter.
"The problem is very localized. We're not seeing it branch out right now," Malloch said. He said the area's close proximity to two heavily traveled routes, Congress Street and Park Avenue, may partially account for the concentration of arrests.
But there's no single reason for where sex is sold or where people seek to buy it, he said. Malloch pointed out that a couple years ago, the area near Portland and Mechanic streets was another hotbed for prostitution.
Police are taking a multi-faceted approach to combating the problem, Malloch said. It includes the john arrests, enforcing an ordinance against drivers who "cruise" in search of sex, and working with the Parkside Neighborhood Association and other neighborhood groups to identify illicit activity.
Arresting prostitutes is difficult, since most know their clientele and can easily spot a police officer, he said. In fact, police made only two arrests of alleged prostitutes last year.
Reactions as complex as the problem
At the request of police, the PNA has submitted statements to the Cumberland County district attorney's office about the impact of prostitution, encouraging prosecutors to pursue cases against johns to the full extent of the law.
The statements have cited examples of women who live in the neighborhood being followed by "creepy guys in cars who are obviously cruising."
"The impact of these activities (is) far-reaching, disturbing the safety and peace of mind, interfering with the quality of life, and disrupting the comfortable daily activities of Parkside residents," the group's latest statement read.
But PNA President Emma Holder cautioned against sensationalizing the problem.
"I have never felt unsafe in Parkside," said Holder, who has lived there since 1998. "Unfortunately, the neighborhood has long been fighting this stigma. It's a complex neighborhood, and (prostitution) here gets a little blown out of proportion by the media."
Prostitution and related criminal activity aren't limited to Parkside, she noted.
"Parkside is the canary in the coal mine of Portland," Holder said. "A city-wide problem will show up here or in Bayside first, (but) violence and unrest is a city-wide issue, driven by malaise and desperation from poor economics."
Regardless of the incidence of prostitution in Parkside, Holder said she applauds the work of police to crack down on customers. "That's absolutely the right approach," she said.
State Street resident Eric Sommer agreed. "Prostitution begins with the guys who are willing to pay for it," he said. "And that's where it should end, too."
But another Parkside resident – and expert on sexuality and prostitution – has a different view.
Unsuitable business
University of Southern Maine sociology professor Wendy Chapkis, of Sherman Street, said prostitution is a form of business that isn't suited for every neighborhood.
"I've always felt as a resident and a researcher that the critical problem with street-level prostitution (in Parkside) is that it's commercial activity happening in a residential neighborhood," she said. "And the disruption caused by that commercial activity is compounded when it is illegal."
Chapkis contrasts that type of prostitution with the infamous case of Alexis Wright, the Kennebunk Zumba instructor who recently began serving a 10-month jail sentence for prostitution and other crimes.
Chapkis said Wright was clearly an "aware, consenting adult" who engaged in prostitution in a place of business – her dance studio. Street prostitutes don't have such an option.
"In the United States, on the streets, prostitutes are usually people who have very few other options," she said. "Prostitution becomes a survival skill."
"When police are a risk and threat to sex workers, it makes their dangerous work even worse," Chapkis said. "Decriminalization (of prostitution) would be a better approach. In places where prostitution is legal, sex workers are organized and protect themselves more effectively."
Legalizing the world's oldest profession is unlikely to happen in Maine, Chapkis admitted. And she said she understands the reactions of her neighbors.
"I have sympathy for the neighbors. I appreciate that this is a complicated problem," she said. "But I don't believe the best solution is increased policing.
"There have to be alternatives. Besides, even if you go in and make arrests it doesn't necessarily have the effect of stopping prostitution. It may just move to another neighborhood."
Regardless of where the problem goes, Malloch said the Police Department is concentrating on protecting the areas where prostitution is a problem now.
"This is more than a victimless crime," he said. "When we hear from residents that someone's wife or daughter can't walk from the car to the house without getting harassed, that's a negative impact for everyone."
William Hall can be reached at 781-3661 ext. 106 or [email protected]. Follow him on Twitter: @hallwilliam4.
Sidebar Elements
A "no cruising" sign is intended to warn potential johns not to drive repeatedly along Weymouth Street in Portland in search of sex for sale.
House to vote on condemning Trump's racist attacks on congresswomen
Cops & Courts
Trial begins for man charged with stabbing woman 11 times in Lewiston
Forecaster Sports
South Portland soccer players head to Iceland and Sweden
Forecaster Sports
South Portland baseball players win a pair of tournaments
Sens. King, Collins, Rep. Pingree rebuke Trump over racist attacks on congresswomen


text:
Craig berry necesitaba un nuevo diseño de camiseta y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 61 diseños de 23 diseñadores freelance.
Hi All
I am a Harley Davidson rider and enthusiast in Australia. I specialise in customising bikes and am going to include my logo on clothing helmets, bikes etc.
I am really looking for a logo for me ! My nickname is SPIKE and I will have this embroided on my clothing and bike seats as well as branding my bikes and helmets.
My bikes feature aggressive blade type airbrush graphics and lots of metal spikes giving them a tough aggressive image. I am simply looking for the word "SPIKE" in some form of edgy, aggressive blade, spike type font. The best example of something similar would be the Crusty Demons Unleashing Hell Logo. Just Google Crusty Demons Logo and you will get some good examples. The logo needs to scream tough ,aggressive , edgy and dangerous !! I am obviously not a designer but I am thinking of things like, circular saw teeth, razor wire, devils tails, metallic looking spikes. knife blades etc. look at the "Blade"style"graphics on the tank of my bike photo I have attached.


text:
Filed Under (Sym) by admin on 24-11-2010
Carbon monoxide If you must run your engine, ensure the place is well ventilated. Never run your engine in a closed area. Run your engine in an open area, if you have to run your engine in a closed area, be sure to use an extractor. Caution Exhaust contains toxic gas which may cause one to lose consciousness and even result in death. Gasoline Gasoline is a low ignition point and explosive material. Work in a well-ventilated place, no flame or spark should be allowed in the work place or where gasoline is being stored. Caution Gasoline is highly flammable, and may explode under some conditions, keep it away from children. Used engine oil Caution Prolonged contact with used engine oil (or transmission oil) may cause skin cancer although it might not be verified. We recommend that you wash your hands with soap and water right after contacting. Keep the used oil beyond reach of children. Hot components Caution Components of the engine and exhaust system can become extremely hot after engine running. They remain very hot even after the engine has been stopped for some time. When performing service work on these parts, wear insulated gloves and wait until cooling off. Battery Caution y Battery emits explosive gases; flame is strictly prohibited. Keep the place well ventilated when charging the battery. y Battery contains sulfuric acid (electrolyte) which can cause serious burns so be careful do not be spray on your eyes or skin. If you get battery acid on your skin, flush it off immediately with water. If you get battery acid in your eyes, flush it off immediately with water and then go to hospital to see an ophthalmologist. y If you swallow it by mistake, drink a lot of water or milk, and take some laxative such as castor oil or vegetable oil and then go to see a doctor. y Keep electrolyte beyond reach of children. Brake shoe Do not use an air hose or a dry brush to clean components of the brake system, use a vacuum cleaner or the equivalent to avoid dust flying. Caution Inhaling dust may cause disorders and cancer of the breathing system. Brake fluid Caution Spilling brake fluid on painted, plastic, or rubber parts may cause damage to the parts. Place a clean towel on the above-mentioned parts for protection when servicing the brake system. Keep the brake fluid beyond reach of children


text:
Waldron, MO – KeepSpicy is a website that is changing the way shoppers and home cooks go about purchasing the kitchen gadgets they need. From their blog-style approach to offering reviews of different kitchen items, showcasing healthy food recipes and providing tips that are geared towards making better food, this website is on its way to becoming a home cook's best friend.
Thousands of people make it their goal to go out and eat as often as possible. Not everyone wants to go out to eat. There are some people who still enjoy the thrill of making a homemade meal and love to get their hands dirty through the food prep process. These home chefs throw their all into making meals and dishes from scratch. So, to make the best food possible these home cooks need the best kitchen equipment on the market. Some people may not know where to look to find the best kitchen equipment for their cooking needs. Especially when shopping online. With a plethora of brands and models readily available for purchase, a home cook could end up buying a product that isn't the best quality or fit for them. That's why companies like KeepSpicy can help during this process.
KeepSpicy provides in-depth reviews about kitchen gadgets and products that can be purchased online and sent to a customer's door. Under any given category, the KeepSpicy website offers reviews on several products they view to be the best. They give the pros and cons of each product and gives a description of it and how each product measures up to several important features that are expected of the products in the category. Each category is up to date and features the best products of now. Many of them take price into consideration when deciding, demonstrating just how thoughtful the creators behind KeepSpicy are.
It is plain to see that the creators behind KeepSpicy want to see shoppers purchasing the right items for their kitchen. And with their updated website, KeepSpicy will no doubt keep their visitors happy with the top picks for this year. Plus, with the healthy recipes, they include for home cooks and food tips geared towards helping each of their dish perfect. KeepSpicy is setting itself up to be a home chef's go to site for everything cooking.
Media Contact
Company Name: KeepSpicy
Contact Person: Norma Olya
Email: email@example.com
Phone: 610-528-6389
City: Waldron
State: Missouri
Country: United States
Website: www.keepspicy.com/


text:
Since today is Arbor Day, let's talk trees.
CFCA President Bob Hentzen is now in Colombia, the sixth of 12 countries on his 8,000-mile trek through Latin America called Walk2gether. Besides building community and strengthening the bonds of unity between CFCA sponsored members, sponsors and staff, Walk2gether is promoting care of the environment.
To counter the serious problem of deforestation, and to motivate people to plant trees, sponsored members and scholarship students planted maya nut trees about every six miles along the Walk2gether route in Guatemala, said Luis CoCon of CFCA's Hermano Pedro project.
The maya nut tree adapts easily to different weather conditions, requires little maintenance, and its fruit is rich in nutrients.
"A lot of our people use the forest for firewood," said CoCon. "But I think the main problem is that the big plantation owners clear hundreds or thousands of trees every day to make room for sugarcane or corn fields."
The Hermano Pedro project planted 100,000 trees in 2009 and hopes to plant 1 million between 2009 and 2011, CoCon said.
|Photo courtesy of www.theequilibriumfund.org. These adaptable trees produce a highly nutritious fruit and can grow to 150 feet.
|Brother Jorge Armas, Hermano Pedro project coordinator, plants a maya nut tree along the Walk2gether route in Guatemala.


text:
For Immediate Release:
The Round Robin Collective presents:
March 13 – April 4, 2010
March 13 – April 4, 2010
Opening reception: Friday, March 12, 7-9 pm
The former convent of St. Cecilia's Parish
The former convent of St. Cecilia's Parish
21 Monitor Street, Brooklyn, NY
Hours: Sat 12-10 pm, Sun-Mon 12-6 pm (or by appointment)
with additional hours for special events
(details at: roundrobinbrooklyn.blogspot.com)
with additional hours for special events
(details at: roundrobinbrooklyn.blogspot.com)
The Round Robin Collective is pleased to announce ECSTATIC, an exhibition and series of events to be held in the former convent of St. Cecilia's Parish in Greenpoint, Brooklyn.
For four weeks, The Round Robin Collective - along with a group of invited artists - will populate the four-story maze of private rooms, living spaces, stairwells, and alcoves previously occupied by nuns. Taking varied approaches to the installation of their separate rooms, individual artists and collaborative teams will present recent works or will respond directly to the building, imbued with its unique history and sacrosanct aura. While some of the participating artists' work deals directly with notions of ecstasy, the title of the show does not allude to an overt theme in the work presented; rather, it refers to the process of making and encountering art and the results produced from inspired relationships. Like the mental transport or rapture that can exist in the contemplation of the divine, the experience of creating and considering art can trigger moments of ecstasy.
Exhibiting artists will include: Lisa Boumstein-Smalley, Mary Billyou, Amanda Browder & Stuart Keeler, Caroline Burghardt, Lisa Caccioppoli, Ofri Cnaani, Chris Cobb, David Coyle, Jeff DeGollier, Martin Esteves, Gisela Insuaste, Jamie Kim, Stephanie Liner, Deirdre McConnell, Katherin McInnis, Emcee C.M., Master of None, Huong Ngo, Christopher Rose, Stephanie Rothenberg, Dorothy Royle, David B. Smith + Brina Thurston, Matthew Spiegelman, Janos Stone, Cassie Thorton + Action Club, Jenny Vogel & David McBride, and Audra Wolowiec.
Curated screenings, workshops, and performances will be held weekly in the former chapel of the convent. Events include: opening party music by Donny Hue and the Colors as well as Irvin Morazan's "Musical Chair Performance," an homage to Saint Cecilia, the patron saint of musicians (3/12); an evening of sound performances with Lary 7, Flying Teeth, and Doom Trumpet (3/13); "Low-Resolution Stories," live cinema with Jenny Vogel and Ofri Cnaani followed by music with Chatter Blip (3/19); "The Alternative Art Space Movement in NYC," a panel discussion with Erin Sickler, Herb Tam, Rob de Oude, and EmCee C.M., Master of None moderated by Mary Billyou (3/20); music by Toys n Tiny Instruments followed by "Diamonds in the Sky," a evening of film/video curated by John Passmore (3/20); "Escape from the Orgone Box: Houdini & Reich on Film," an evening of film with live soundtracks by Séance presented by Bradley Eros and Marianne Shaneen (3/26); a collective sewing day with Amanda Browder for the construction of the public artwork, "Future Phenomena" (3/27); an empanada and tamale demonstration/potluck event hosted by Gisela Insuaste and Irvin Morazan (3/28); closing the exhibition, a film/video screening curated by Jem Cohen (4/3); additional events to be announced. Details and updates regarding all the events are available on our web site.
The Round Robin Collective is a Brooklyn-based group of artists established in 2008 to forge connections and create a space for dialogue in and out of the studio. Meeting for monthly studio visits, members of the collective work in all media, fostering a dynamic exchange across disciplines and outside the commercial sphere.
For more information or press inquiries, please contact email@example.com or visit: roundrobinbrooklyn.blogspot.com. Opening night sponsored by Great Bar Harry, Brooklyn, (www.bargreatharry.com) and Powder Blue Design and partial sponsorship for events by Dandelion Wine, Brooklyn, (www.dandelionwinenyc.com).


text:
Euro Foods pays £18,000 for potentially deadly food adulteration
Cumbria County Council's Trading Standards team brought the case against the food manufacturer and wholesaler when a county-wide sampling project uncovered undeclared peanuts in a chicken tikka masala product supplied to two takeaways in Cockermouth.
Peanuts can cause severe allergic reactions that can result in death.
When Trading Standards officers visited Fiza Spice and Indian Spice, they asked the takeaway owners whether the chicken tikka masala product contained peanuts. The owners told them the products were peanut free.
Samples of the product were removed for testing, which found peanuts to be present in both products.
A complex investigation followed, which established that wholesaler Euro Foods had supplied ground nuts (peanuts), instead of almond powder as requested, to another wholesaler which had, in turn, supplied the two takeaways.
Life-threatening actions
Trading Standards service manager Angela Jones said: "Trading Standards are satisfied that this verdict, and this case, highlights the importance of labelling food correctly.
"Peanuts are a cheaper food to source than almonds, and it is absolutely unacceptable that the almonds were substituted and sent to the takeaway outlets, which are not at fault. In the worst case scenario, the actions of Euro Foods could have been life threatening for some people. We were lucky in this instance that no peanut allergy sufferers were affected by these incorrect supplies."
Allergy UK's director of clinical services Maureen Jenkins told FoodManufacture.co.uk: "Food allergy is a serious, sometimes life-threatening condition, which should not be underestimated. Sufferers of food allergies often meticulously study food labels in an effort to manage their condition and avoid a reaction.
"Correct food labelling is vital to help sufferers keep their symptoms at bay, even the smallest error could be potentially life threatening for someone with a severe allergy. A person may be safe to eat one type of nut, but not another."
'Alarming' rise in allergies
It's a problem that food manufacturers need to be increasingly aware of as allergies are rising at an "alarming" rate, according to Allergy UK.
Jenkins said: "Allergies to peanuts and tree nuts are the most common food allergies in adults and children. Peanut allergy is becoming ever more commonplace, with recent studies showing that the rate of peanut allergy has doubled over a five-year period both here in Europe and in the United States."
Prior to the first publication of this article, FoodManufacture.co.uk made several attempts to contact Euro Foods for comment but the food manufacturer did not return any calls or reply to emails.


text:
Ryan Seacrest has a thing about keyboards. The TV host and media personality has long carried two phones -- an iPhone and a BlackBerry for its physical QWERTY keyboard.
But he has seemingly decided that's no way to live his life anymore. Along with his friend Laurence Hallier, Seacrest has created the Typo Keyboard Case, an iPhone case with a physical keyboard.
According to All Things D, Seacrest has invested $1 million into the case, set to debut in January 2014 at the annual Consumer Electronics Show in Las Vegas. The company would not confirm Seacrest's financial investment when reached by ABC News.
The $99 Typo Keyboard case will work with an iPhone 5 and 5s. Similar to a Mophie Case for the iPhone, you slide two parts of the keyboard-equipped case onto the phone. You then power on the case and connect it via Bluetooth to the iPhone. The keyboard looks extremely similar to the keyboard on the BlackBerry Q10, with frets to separate the keys. The case does conceal the iPhone's home button but a button to the right of the keyboard replaces the function.
It is available now for pre-order and will ship in January.
But the Typo Keyboard case isn't the first product to attempt to bring a QWERTY keyboard to the iPhone. Others from BoxWave and Dobi have all tried to solve this age-old problem, but the use of Bluetooth is frustrating and the keyboards themselves were slow and added a lot of heft to the phone.
Seacrest and Hailler said they felt the same way about those, which is apparently why they embarked on creating the Typo case in the first place. "After ordering every iPhone keyboard available, we realized that there was no solution that worked well," they state on the Typo Case website.
They vow that this case provides a "butter-smooth" experience and adds only a fourth of an inch to the thickness of the iPhone. If that proves to be true, Seacrest and the rest of us die-hard keyboard fans may have one more thing to celebrate on New Year's Eve.


text:
You Heard It Right, Adam Sandler's 'Grown Ups' Sequel May Soon Be in the Works
Comedian Adam Sandler doesn't usually make sequels to his movies — for good reason — but he might be going ahead with one for his 2010 hit comedy 'Grown Ups.'
Sandler's Happy Madison Productions and Sony Pictures are talking about making the sequel and bringing back Sandler's co-stars Chris Rock, Kevin James, David Spade and Rob Schneider. Nothing is official, but sources say that Sony is talking with the writer of the first film, Fred Wolf, about writing the next movie.
Wolf is also the writer behind 'Joe Dirt,' 'Dickie Roberts: Former Child Star,' 'Dirty Work,' 'Black Sheep' and 'Without a Paddle.' He also wrote for 'Saturday Night Live' and the talk shows 'The Chevy Chase Show' and 'The Pat Sajak Show.'
So what would possess Happy Madison Productions to even think about making a sequel to this movie? Perhaps because 'Grown Ups' grossed, shockingly, $271 million and is the highest-grossing film of Sandler's career. Relive the arguably funny trailer below.


text:
9th May 2017
Adrianna Abreu of Grayling San Francisco explores how AI is significantly transforming the FinTech Industry.
Any FinTech company you approach today will tell you their biggest challenge is building consumer trust. We trust apps like GrubHub to deliver our food order, we trust Amazon to deliver products we order at a click of a button, and we trust Google with our location at all times.
So why do FinTech companies struggle to get consumers to trust them with their money?
This is where AI and its role in FinTech comes in to play. Rather than just being a feature of customer service or an investing assistant, investment in AI (which reached a record high in 2016) will allow it to scale and not only focus on building the trust of the consumer, but also become the core component of most platforms, and will be able to solve basic financial problems – like stabilizing your portfolio in a bear market and automatically opening a 529 after your first child.
This growth and the future of FinTech lies in a combination of big data and artificial intelligence. The rise of AI financial advice apps like Cleo and LearnLux are initial indicators that millennials not only trust AI, but that AI has the extensive capability to speak and teach financial management. By intervening early with budgeting, saving, and spending alerts, AI is systematically teaching millennial consumers Finance 101.
And it's not only startups getting on the AI train. Bank of America's Erica AI Bot was developed to help BofA customers make smarter financial decisions. Customers can chat with Erica via voice or text message about making payments, checking balances, saving money, or paying down debt. She can also assist in looking up FICO scores and checking out educational videos. Erica was built with the goal to create an AI bot that proves to customers that they can have a good or better customer experience with AI.
In five years, AI will have the capability to out-think a banker, predict like a trader, diversify your portfolio based on your stage of life, and become integrated into your smartphone so Siri can give you details regarding your 401k. But even with this new revolution approaching, and the $1.2 billion in VC money to back it, the challenge in FinTech still remains: how much do we really trust AI with our money?
We're already seeing a rise of heated conversations around trust and AI's role in FinTech – look no further than Jamie Dimon's recent attack on FinTech and the formation of the CFDR. The next challenge for us in comms is going to be how to redirect the conversation beyond traditional AI conversations, like the overdone "the robos are coming," and into the benefits (i.e. convenience, security, regulation, trust) that new AI-native platforms will offer.
Adrianna Abreu is part of Grayling's San Francisco FinTech team. Download the PDF for details.
Grayling Team
15th November 2016
Will Kunkel, Executive Vice President for Creative and Content in Grayling New York, on the final of our #7for17 trends, Live and Uncut'Timing is everything' has been a favorite line to many but...Read More
8th November 2016
Danica Ross, Grayling San Francisco US Executive Vice President, on how brands can guide themselves through the 'the new space race' – part of our #7for17 trends series.In an era where brands...Read More
3rd November 2016
Russell Patten, Chair of Grayling's European Public Affairs practice, looks at one of the major political trends as part of our #7for17 series. It's been a turbulent year in politics, with the...Read More


text:
Stories on: DDOS attacks, Steam Summer Sale, Twitch, and Valve
CheckPoint is our gaming news comedy and commentary show. It turns out that games industry news is far weirder than you might have originally thought, and LRR's not going to let it get away with that.
CheckPoint 350 - Solo Fantasy
Stories on: FFXIV Shadowbringers, Nintendo Switch Lite, G2A, and Slay the Spire Sailor Moon Mod
CheckPoint 348 - Mini Tower of Power
Stories on: Sega Genesis Mini, Destiny, Cuphead, and Pokemon
CheckPoint 347 - Ouya What's This?
Stories on: Ouya, Playdate, World of Warcraft Classic, Assassin's Creed Unity, and Nintendo
CheckPoint 346 - Rock Hand
Stories on: PUBG mobile, Eagle Dynamics, Fallout New Vegas speedrunning, and Pokemon (specifically[…]
CheckPoint 345 - Wave Goodbye
Stories on: Tencent, BlizzCon, Gearbox, and Fortnite
CheckPoint 344 - Persona 5.5
Stories on: Twitch, Assassins Creed Unity Steam Reviews, Mortal Kombat 11, and Persona 5 The Royal


text:
A former YMCA in western New York that was forced to close in March is continuing to offer fitness programming after being absorbed by another local nonprofit agency.
The Chemung County YMCA, Elmira, NY, announced at the beginning of the year that it was unable to continue operating due to financial reasons. At the time of closure, the Y's rent was about $8,000 in arrears, which it had agreed to repay by surrendering its fitness equipment to the county, according to several media outlets.
News of the facility's closure spurred a flurry of activity from local residents. About 2,000 concerned citizens signed a petition asking county officials to save the Y, and small grassroots groups of local seniors and students at Mansfield University in nearby Mansfield, PA, worked to find a solution that would keep the facility operating and solvent.
The citizens' efforts paid off. This month, the former Y was adopted by The Senior Center Inc., which will lease the fitness facility from the county and operate it as an annex for the next 12 months. A number of the former Y's patrons and members made donations and took on annual memberships to provide an influx of cash. Another supporter paid off the facility's $5,000 equipment bill.
A volunteer committee made up of Senior Center and former Y members has devised a budget and new fee structure for members and guests to help the facility to break even. Other volunteer groups from the community are helping with fundraising efforts, participating in refurbishment projects and exploring other ways to increase revenues, including updated programming options.
The new Chemung County Family Fitness Center will hold a grand-opening celebration for the public on May 21.


text:
SOUTH SAN FRANCISCO, CA, May 15, 2013 (Marketwired via COMTEX) -- Onyx Pharmaceuticals, Inc. ONXX today announced the upcoming presentations of data highlighting Nexavar(R) (sorafenib) tablets, Kyprolis(R) (carfilzomib) for Injection, and Stivarga(R) (regorafenib) tablets across a range of cancers. These presentations will take place at the 49th American Society of Clinical Oncology (ASCO) Annual Meeting, May 31 - June 4, 2013, in Chicago, IL.
"The data being presented at ASCO add to the depth of our understanding of how these medicines work across tumor types and treatment settings," said Pablo Cagnoni, M.D., Executive Vice President, Global Research & Development and Technical Operations at Onyx Pharmaceuticals. "We are committed to exploring therapies in difficult-to-treat cancers for patients who have limited treatment options."
Nexavar(R) (sorafenib) tablets
Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The Phase 3 DECISION trial
-- Dr. Marcia Brose, University of Pennsylvania Health System, United States -- Sunday, June 2, 2013 -- Oral Presentation: 3:20 - 3:35 p.m., N Hall B1 -- Plenary Session - Special Sessions, Core Sessions -- Abstract # 4
Final analysis of GIDEON (Global Investigation of Therapeutic Decisions in Hepatocellular Carcinoma [HCC] and of Its Treatment with Sorafenib [Sor]) in > 3000 Sor-treated patients (pts): clinical findings in pts with liver dysfunction
-- Dr. Jorge Marrero, University of Michigan, United States -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Gastrointestinal (Noncolorectal) Cancer -- Abstract # 4126
Kyprolis(R) (carfilzomib) for Injection
Final results from the Phase 1b/2 study (PX-171-006) of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) in patients with relapsed or progressive multiple myeloma
-- Dr. Michael Wang, MD Anderson Cancer Center, United States -- Monday, June 3, 2013 -- Poster viewing: 1:15 - 5:15 p.m., E450b -- Poster discussion: 4:45 - 5:45 p.m., E354b -- Poster discussion session - Lymphoma and Plasma Cell Disorders, Poster #9 -- Abstract # 8529
Effect of CMP, carfilzomib (CFZ) plus melphalan-prednisone (MP), on response rates in elderly patients (pts) with newly diagnosed multiple myeloma (NDMM): Results of a Phase (Ph) 1/2 trial
-- Dr. Cyrille Touzeau, University of Nantes, France -- Monday, June 3, 2013 -- Oral Presentation: 9:15 - 9:30 a.m., E Arie Crown Theater -- Oral abstract session - Myeloma -- Abstract # 8513
Retrospective analysis of cardiovascular (CV) events following compassionate use of carfilzomib (CFZ) in patients (Pts) with relapsed and refractory multiple myeloma (RRMM)
-- Dr. Shebli Atrash, University of Arkansas for Medical Sciences, United States -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Lymphoma and Plasma Cell Disorders -- Abstract # 8595
Results of a Phase 1/2 study (NCT01365559) of carfilzomib (CFZ) replacing bortezomib (BTZ) in BTZ-containing regimens for BTZ-treated patients (pts) with relapsed and refractory multiple myeloma (MM)
-- Dr. James R. Berenson, Institute for Myeloma & Bone Cancer Research, United States -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Lymphoma and Plasma Cell Disorders -- Abstract # 8599
Results of a Phase 1 trial of the proteasome inhibitor carfilzomib in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL)
-- Dr. Jennifer Ann Woyach, Ohio State University, United States -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Leukemia, Myelodysplasia, and Transplantation -- Abstract # 7077
Treatment outcome with the combination of carfilzomib, lenalidomide, and low-dose dexamethasone (CRd) for newly diagnosed multiple myeloma (NDMM) after extended follow-up
-- Dr. Andrzej J. Jakubowiak, University of Chicago, United States -- Monday, June 3, 2013 -- Poster viewing: 1:15 - 5:15 p.m., E450b -- Poster discussion: 4:45 - 5:45 p.m., E354b -- Poster discussion session - Lymphoma and Plasma Cell Disorders, Poster #23 -- Abstract # 8543
Stivarga(R) (regorafenib) tablets
Mutational analysis of plasma DNA from patients (pts) in the Phase 3 GRID study of regorafenib (REG) vs placebo (PL) in tyrosine kinase inhibitor (TKI)-refractory GIST: correlating genotype with clinical outcomes
-- Dr. George Demetri, Dana-Farber Cancer Institute, United States -- Monday, June 3, 2013 -- Oral Presentation: 3:45 - 4:00 p.m., S100bc -- Oral abstract session - Sarcoma -- Abstract # 10503
Results from a Phase 3 trial (GRID) evaluating regorafenib (REG) in metastatic gastrointestinal stromal tumour (GIST): subgroup analysis of outcomes based on pretreatment characteristics
-- Dr. Heikki Joensuu, Helsinki University Central Hospital, Finland -- Saturday, June 1, 2013 -- Poster viewing: 1:15 - 5:00 p.m., S Hall A2 -- General poster session - Sarcoma -- Abstract # 10551
Regorafenib (REG) in patients with hepatocellular carcinoma (HCC) progressing following sorafenib: an ongoing randomized, double-blind, Phase 3 trial
-- Dr. Ann-Lii Cheng, National Taiwan University Hospital, Taipei -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Gastrointestinal (Noncolorectal) Cancer -- Abstract # TPS4163 (Trials in Progress)
Time profile of adverse events (AEs) from regorafenib (REG) treatment for metastatic colorectal cancer (mCRC) in the Phase 3 CORRECT study
-- Dr. Axel Grothey, Mayo Clinic, United States -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Gastrointestinal (Colorectal) Cancer -- Abstract # 3637
Regorafenib (REG) in progressive metastatic colorectal cancer (mCRC): analysis of age subgroups in the Phase 3 CORRECT trial
-- Dr. Eric van Cutsem, University Hospital Leuven in Gasthuisberg, Belgium -- Sunday, June 2, 2013 -- Poster viewing: 8:00 - 11:45 a.m., S Hall A2 -- General poster session - Gastrointestinal (Colorectal) Cancer -- Abstract # 3636
Analysis of plasma protein biomarkers from the CORRECT Phase 3 study of regorafenib for metastatic colorectal cancer
-- Dr. Heinz-Josef Lenz, USC Norris Comprehensive Cancer Center, United States -- Tuesday, June 4, 2013 -- Poster viewing: 8:00 - 12:00 p.m., S405 -- Poster discussion: 11:30 - 12:30 p.m., S406 -- Poster discussion session - Gastrointestinal (Colorectal) Cancer, Poster #6 -- Abstract # 3514
About Nexavar(R) (sorafenib) Tablets
Nexavar is approved in the U.S. for the treatment of patients with unresectable hepatocellular carcinoma and for the treatment of patients with advanced renal cell carcinoma. Nexavar is thought to inhibit both the tumor cell and tumor vasculature. In preclinical studies, Nexavar has been shown to inhibit multiple kinases thought to be involved in both cell proliferation (growth) and angiogenesis (blood supply) -- two important processes that enable cancer growth. These kinases include Raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET.
Nexavar is currently approved in more than 100 countries. Nexavar is also being evaluated by Bayer and Onyx, international study groups, government agencies and individual investigators in a range of cancers.
Important Safety Considerations For Nexavar(R) (sorafenib) Tablets
Nexavar in combination with carboplatin and paclitaxel is contraindicated in patients with squamous cell lung cancer.
Cardiac ischemia and/or myocardial infarction may occur. Temporary or permanent discontinuation of Nexavar should be considered in patients who develop cardiac ischemia and/or myocardial infarction.
An increased risk of bleeding may occur following Nexavar administration. If bleeding necessitates medical intervention, consider permanent discontinuation of Nexavar.
Hypertension may occur early in the course of treatment. Monitor blood pressure weekly during the first 6 weeks and periodically thereafter and treat, if required.
Hand-foot skin reaction and rash are common and management may include topical therapies for symptomatic relief. In cases of any severe or persistent adverse reactions, temporary treatment interruption, dose modification, or permanent discontinuation of Nexavar should be considered. Nexavar should be discontinued if Stevens-Johnson Syndrome or toxic epidermal necrolysis are suspected as these may be life threatening.
Gastrointestinal perforation was an uncommon adverse reaction and has been reported in less than 1% of patients taking Nexavar. Discontinue Nexavar in the event of a gastrointestinal perforation.
Patients taking concomitant warfarin should be monitored regularly for changes in prothrombin time (PT), International Normalized Ratio (INR) or clinical bleeding episodes.
Temporary interruption of Nexavar therapy is recommended in patients undergoing major surgical procedures.
Nexavar in combination with gemcitabine/cisplatin is not recommended in patients with squamous cell lung cancer.
The safety and effectiveness of Nexavar has not been established in patients with non-small cell lung cancer.
Nexavar can prolong the QT/QTc interval and increase the risk for ventricular arrhythmias.
Avoid use in patients with congenital long QT syndrome and monitor patients with congestive heart failure, bradyarrhythmias, drugs known to prolong the QT interval, and electrolyte abnormalities.
Drug-induced hepatitis with Nexavar may result in hepatic failure and death. Liver function tests should be monitored regularly and in cases of increased transaminases without alternative explanation Nexavar should be discontinued.
Nexavar may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while on Nexavar and female patients should also be advised against breastfeeding while receiving Nexavar.
Elevations in serum lipase and reductions in serum phosphate of unknown etiology have been associated with Nexavar.
Avoid concomitant use of strong CYP3A4 inducers, when possible, because inducers can decrease the systemic exposure of Nexavar. Nexavar exposure decreases when coadministered with oral neomycin. Effects of other antibiotics on Nexavar pharmacokinetics have not been studied.
Most common adverse reactions reported for Nexavar-treated patients vs. placebo-treated patients in unresectable HCC, respectively, were: diarrhea (55% vs. 25%), fatigue (46% vs. 45%), abdominal pain (31% vs. 26%), weight loss (30% vs. 10%), anorexia (29% vs. 18%), nausea (24% vs. 20%), and hand-foot skin reaction (21% vs. 3%). Grade 3/4 adverse reactions were 45% vs. 32%.
Most common adverse reactions reported for Nexavar-treated patients vs. placebo-treated patients in advanced RCC, respectively, were: diarrhea (43% vs. 13%), rash/desquamation (40% vs. 16%), fatigue (37% vs. 28%), hand-foot skin reaction (30% vs. 7%), alopecia (27% vs. 3%), and nausea (23% vs. 19%). Grade 3/4 adverse reactions were 38% vs. 28%.
For information about Nexavar including U.S. Nexavar prescribing information, visit www.nexavar-us.com or call 1.866.NEXAVAR (1.866.639.2827).
Indication and Important Safety Information for Kyprolis(R) (carfilzomib) for Injection
Kyprolis(TM) (carfilzomib) for Injection is indicated for the treatment of patients with multiple myeloma who have received at least 2 prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval is based on response rate. Clinical benefit, such as improvement in survival or symptoms, has not been verified.
The safety of KYPROLIS was evaluated in clinical studies of 526 patients with relapsed and/or refractory multiple myeloma.
Death due to cardiac arrest has occurred within a day of KYPROLIS administration. New onset or worsening of pre-existing congestive heart failure with decreased left ventricular function or myocardial ischemia have occurred following administration of KYPROLIS. Cardiac failure events (e.g., cardiac failure congestive, pulmonary edema, ejection fraction decreased) were reported in 7% of patients. Monitor for cardiac complications and manage promptly. Withhold KYPROLIS for Grade 3 or 4 cardiac events until recovery and consider whether to restart KYPROLIS based on a benefit/risk assessment. Patients with New York Heart Association Class III and IV heart failure, myocardial infarction in the preceding 6 months, and conduction abnormalities uncontrolled by medications may be at greater risk for cardiac complications.
Pulmonary arterial hypertension (PAH) was reported in 2% of patients treated with KYPROLIS and was Grade 3 or greater in less than 1% of patients. Evaluate with cardiac imaging and/or other tests as indicated. Withhold KYPROLIS for pulmonary hypertension until resolved or returned to baseline and consider whether to restart KYPROLIS based on a benefit/risk assessment.
Dyspnea was reported in 35% of patients enrolled in clinical trials. Grade 3 dyspnea occurred in 5%; no Grade 4 events, and 1 death (Grade 5) was reported. Monitor and manage dyspnea immediately; interrupt KYPROLIS until symptoms have resolved or returned to baseline.
Infusion reactions were characterized by a spectrum of systemic symptoms, including fever, chills, arthralgia, myalgia, facial flushing, facial edema, vomiting, weakness, shortness of breath, hypotension, syncope, chest tightness, or angina. These reactions can occur immediately following infusion or up to 24 hours after administration of KYPROLIS. Administer dexamethasone prior to KYPROLIS to reduce the incidence and severity of reactions. Inform patients of the risk and symptoms, and to contact physician if symptoms of an infusion reaction occur.
Tumor lysis syndrome (TLS) occurred following KYPROLIS administration in < 1% of patients. Patients with multiple myeloma and a high tumor burden should be considered to be at greater risk for TLS. Prior to receiving KYPROLIS, ensure that patients are well hydrated. Monitor for evidence of TLS during treatment, and manage promptly. Interrupt KYPROLIS until TLS is resolved.
KYPROLIS causes thrombocytopenia with platelet nadirs occurring around Day 8 of each 28-day cycle and recovery to baseline by the start of the next 28-day cycle. In patients with multiple myeloma, 36% of patients experienced thrombocytopenia, including Grade 4 in 10%. Thrombocytopenia following KYPROLIS administration resulted in a dose reduction in 1% of patients and discontinuation of treatment with KYPROLIS in < 1% of patients. Monitor platelet counts frequently during treatment with KYPROLIS. Reduce or interrupt dose as clinically indicated.
Cases of hepatic failure, including fatal cases, have been reported (< 1%). KYPROLIS can cause elevations of serum transaminases and bilirubin. Withhold KYPROLIS in patients experiencing Grade 3 or greater elevations of transaminases, bilirubin, or other liver enzyme abnormalities until resolved or returned to baseline. After resolution, consider if restarting KYPROLIS is appropriate. Monitor liver enzymes frequently.
KYPROLIS can cause fetal harm when administered to a pregnant woman based on its mechanism of action and findings in animals. There are no adequate and well-controlled studies in pregnant women using KYPROLIS. Carfilzomib caused embryo-fetal toxicity in pregnant rabbits at doses that were lower than in patients receiving the recommended dose. Females of reproductive potential should be advised to avoid becoming pregnant while being treated with KYPROLIS.
Serious adverse reactions were reported in 45% of patients. The most common serious adverse reactions were pneumonia (10%), acute renal failure (4%), pyrexia (3%), and congestive heart failure (3%). Adverse reactions leading to discontinuation of KYPROLIS occurred in 15% of patients and included congestive heart failure (2%), cardiac arrest, dyspnea, increased blood creatinine, and acute renal failure (1% each).
The most common adverse reactions (incidence ≥ 30%) were fatigue (56%), anemia (47%), nausea (45%), thrombocytopenia (36%), dyspnea (35%), diarrhea (33%), and pyrexia (30%).
Since dialysis clearance of KYPROLIS concentrations has not been studied, the drug should be administered after the dialysis procedure.
Full prescribing information is available at http://www.kyprolis.com.
About Stivarga(R) (regorafenib) Tablets In the United States, Stivarga is indicated for the treatment of patients with mCRC who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. It is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.
Stivarga is an inhibitor of multiple kinases involved in normal cellular functions and in pathologic processes such as oncogenesis, tumor angiogenesis, and maintenance of the tumor microenvironment.
For full prescribing information, including BOXED WARNING, visit www.stivarga-us.com.
Important Safety Information For Stivarga(R) (regorafenib) Tablets
-- Severe and sometimes fatal hepatotoxicity has been observed in clinical trials. -- Monitor hepatic function prior to and during treatment. -- Interrupt and then reduce or discontinue Stivarga for hepatotoxicity as manifested by elevated liver function tests or hepatocellular necrosis, depending upon severity and persistence.
Severe drug-induced liver injury with fatal outcome occurred in 0.3% of 1200 Stivarga-treated patients across all clinical trials. In metastatic colorectal cancer (mCRC), fatal hepatic failure occurred in 1.6% of patients in the Stivarga arm and in 0.4% of patients in the placebo arm; all the patients with hepatic failure had metastatic disease in the liver. In gastrointestinal stromal tumor (GIST), fatal hepatic failure occurred in 0.8% of patients in the Stivarga arm.
Obtain liver function tests (ALT, AST, and bilirubin) before initiation of Stivarga and monitor at least every 2 weeks during the first 2 months of treatment. Thereafter, monitor monthly or more frequently as clinically indicated. Monitor liver function tests weekly in patients experiencing elevated liver function tests until improvement to less than 3 times the upper limit of normal (ULN) or baseline values. Temporarily hold and then reduce or permanently discontinue Stivarga, depending on the severity and persistence of hepatotoxicity as manifested by elevated liver function tests or hepatocellular necrosis.
Stivarga caused an increased incidence of hemorrhage. The overall incidence (Grades 1-5) was 21% and 11% with Stivarga vs 8% and 3% with placebo in mCRC and GIST patients, respectively. Fatal hemorrhage occurred in 4 of 632 (0.6%) Stivarga-treated patients and involved the respiratory, gastrointestinal, or genitourinary tracts. Permanently discontinue Stivarga in patients with severe or life-threatening hemorrhage and monitor INR levels more frequently in patients receiving warfarin.
Stivarga caused an increased incidence of hand-foot skin reaction (HFSR) (also known as palmar-plantar erythrodysesthesia [PPE]) and severe rash, frequently requiring dose modification. The overall incidence was 45% and 67% with Stivarga vs 7% and 12% with placebo in mCRC and GIST patients, respectively. Incidence of Grade 3 HFSR (17% vs 0% in mCRC and 22% vs 0% in GIST), Grade 3 rash (6% vs < 1% in mCRC and 7% vs 0% in GIST), serious adverse reactions of erythema multiforme (0.2% vs 0% in mCRC), and Stevens-Johnson syndrome (0.2% vs 0% in mCRC) was higher in Stivarga-treated patients. Toxic epidermal necrolysis occurred in 0.17% of 1200 Stivarga-treated patients across all clinical trials. Withhold Stivarga, reduce the dose, or permanently discontinue depending on the severity and persistence of dermatologic toxicity.
Stivarga caused an increased incidence of hypertension (30% vs 8% in mCRC and 59% vs 27% in GIST with Stivarga vs placebo, respectively). Hypertensive crisis occurred in 0.25% of 1200 Stivarga-treated patients across all clinical trials. Do not initiate Stivarga until blood pressure is adequately controlled. Monitor blood pressure weekly for the first 6 weeks of treatment and then every cycle, or more frequently, as clinically indicated. Temporarily or permanently withhold Stivarga for severe or uncontrolled hypertension.
Stivarga increased the incidence of myocardial ischemia and infarction in mCRC (1.2% with Stivarga vs 0.4% with placebo). Withhold Stivarga in patients who develop new or acute cardiac ischemia or infarction, and resume only after resolution of acute cardiac ischemic events if the potential benefits outweigh the risks of further cardiac ischemia.
Reversible Posterior Leukoencephalopathy Syndrome (RPLS) occurred in 1 of 1200 Stivarga-treated patients across all clinical trials. Perform an evaluation for RPLS in any patient presenting with seizures, headache, visual disturbances, confusion, or altered mental function. Confirm the diagnosis of RPLS with MRI and discontinue Stivarga in patients who develop RPLS.
Gastrointestinal perforation or fistula occurred in 0.6% of 1200 patients treated with Stivarga across clinical trials. In GIST, 2.1% (4/188) of Stivarga-treated patients developed gastrointestinal fistula or perforation: of these, 2 cases of gastrointestinal perforation were fatal. Permanently discontinue Stivarga in patients who develop gastrointestinal perforation or fistula.
Treatment with Stivarga should be stopped at least 2 weeks prior to scheduled surgery. Resuming treatment after surgery should be based on clinical judgment of adequate wound healing. Stivarga should be discontinued in patients with wound dehiscence.
Stivarga can cause fetal harm when administered to a pregnant woman. Use effective contraception during treatment and up to 2 months after completion of therapy. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Stivarga, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
The most frequently observed adverse drug reactions (≥ 30%) in Stivarga-treated patients vs placebo-treated patients in mCRC, respectively, were: asthenia/fatigue (64% vs 46%), decreased appetite and food intake (47% vs 28%), HFSR/PPE (45% vs 7%), diarrhea (43% vs 17%), mucositis (33% vs 5%), weight loss (32% vs 10%), infection (31% vs 17%), hypertension (30% vs 8%), and dysphonia (30% vs 6%).
The most frequently observed adverse drug reactions (≥ 30%) in Stivarga-treated patients vs placebo-treated patients in GIST, respectively, were: HFSR/PPE (67% vs 15%), hypertension (59% vs 27%), asthenia/fatigue (52% vs 39%), diarrhea (47% vs 9%), mucositis (40% vs 8%), dysphonia (39% vs 9%), infection (32% vs 5%), decreased appetite and food intake (31% vs 21%), and rash (30% vs 3%).
For full prescribing information, including BOXED WARNING, visit www.stivarga-us.com.
About Onyx Pharmaceuticals, Inc.
Based in South San Francisco, California, Onyx Pharmaceuticals, Inc. is a global biopharmaceutical company engaged in the development and commercialization of innovative therapies for improving the lives of people with cancer. The company is focused on developing novel medicines that target key molecular pathways. For more information about Onyx, visit the company's website at www.onyx.com. Onyx Pharmaceuticals is on Twitter. Sign up to follow our Twitter feed @OnyxPharm at http://twitter.com/OnyxPharm.
Forward-Looking Statements
This news release contains "forward-looking statements" of Onyx within the meaning of the federal securities laws. These forward-looking statements include without limitation, statements regarding the progress and results of the clinical development, safety, regulatory processes, commercialization efforts or commercial potential of Nexavar(R) (sorafenib) tablets, Kyprolis(R) (carfilzomib) for Injection and Stivarga(R) (regorafenib) tablets. These statements are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including risks related to the development and commercialization of pharmaceutical products. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Reference should be made to Onyx's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2013, filed with the Securities and Exchange Commission under the heading "Risk Factors" for a more detailed description of such factors. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date of this release. Onyx undertakes no obligation to update publicly any forward-looking statements to reflect new information, events, or circumstances after the date of this release except as required by law.
Contacts: Investors Amy Figueroa Senior Director, Investor Relations (650) 266-2398 Media Lori Melançon Senior Director, Corporate Communications (650) 266-2394
SOURCE: Onyx Pharmaceuticals, Inc.
(C) 2013 Marketwire L.P. All rights reserved.


text:
Check out our interactive map below to see all registered Eco-Schools and their award levels.
Register now and join us as an Eco-School!
Has your school already registered? Click on your state to see a list of registered schools.
Want to share eco-tips with someone at another school? Click on the school listing for the coordinator's contact information.
This FREE program helps schools improve academic performance, save money and conserve resources.
Learn more >>


text:
Learn how to animate anything along an SVG path.
John Polacek
Tristan Mugford, @tmugford
James Stone, @mimeartist
Petr Tichy
Adam Alicki
Elliot Geno, @ElliotGeno
Thomas Summerall
Jeff Batt, @jeffbatt01
Now you'll begin receiving the latest GreenSock updates, exclusive offers, and more right in your inbox. Welcome aboard.
Code Pen
Get an all-access pass to premium plugins, offers, and more!
Get the latest updates on GreenSock products, exclusive offers, and more right in your inbox.
Your information will always be kept confidential.
Copy/paste this code into your HTML:
<script src="https://cdnjs.cloudflare.com/ajax/libs/gsap/2.1.3/TweenMax.min.js"></script>
By using GreenSock code, you agree to the terms of use.
For an all-access pass to premium content


text:
By JOHN FLOWERS
RIPTON — Road crews on Wednesday were still stabilizing roads, culverts and small bridges decimated by a powerful June 14 rainstorm that stranded dozens of residents in Ripton and East Middlebury.
"All we can do right now is fill in the ruts and get people moving," said Ripton Road Commissioner Ron Wimett, who with other state and local workers has spent untold hours since Saturday's rainstorm at the controls of heavy equipment, filling massive craters and gullies carved into the North Branch Road and other rural lanes that could not stand up to the torrential downpour that forced the Middlebury River and its tributaries to hop their respective banks. One estimate indicated more than six inches of rain fell in Ripton during just a few hours Saturday night.
"We're hoping people are safe and that the federal government and someone can help us," Wimett added. "We can't incur costs like this."
Vermont Emergency Management (VEM) officials on Tuesday were unsure whether the storm damage in Addison and Rutland counties would amount to the $1 million necessary to trigger a federal declaration of emergency, which would result in the release of government aid.
To qualify for Federal Emergency Management Agency (FEMA) assistance, the state must sustain approximately $1 million in damage to public infrastructure like roads, bridges, public buildings, or any other municipal property. There are also county thresholds that need to be met. If local estimates are correct, Addison and Rutland counties may meet the criteria.
Wimett, on Tuesday evening, said he was confident the repair bill will reach seven figures.
"With the cost of materials and fuel prices, we'll reach $1 million, no problem," he said.
By ANDY KIRKALDY
FERRISBURGH — Ferrisburgh Central School officials have decided not to try to shoehorn the recently approved $1.5 million upgrades to the school into this summer, instead opting to plan the work for next summer.
FCS board chairwoman Adela Langrock said board members had initially hoped the project — including replacing the school's failing heating system, installing a new ventilation system and windows, replacing stained ceiling tiles and rotting eaves, and upgrading its electrical system — could be done without interfering with education this fall.
But as they learned more about the bidding process, its projected timetable and the needs of workers during the job, Langrock said, they realized that goal could not be met.
"Given the level of engineering, and the coordination of all of it, it's not feasible for it to be completed this summer ... It would be better to do it next year, to move in the first day of (next) summer and complete it with everyone off site," she said. "We just felt like it would be very disruptive for the next academic year if we started this summer."
By the time bids could be sent out, sorted out and accepted, and then work begun, it would be August, Langrock said. Students would have to be shielded from construction debris and dust, noise would be an issue, and workers would need the equivalent of four empty classrooms to work on at any given time — space the school does not have.
"The amount of disruption for our program would be astronomical ... We just have nowhere to put these kids," Langrock said.
By CYRUS LEVESQUE
ADDISON COUNTY — A proposed increase in the number of muzzle-loading permits issued for antlerless deer will affect some parts of the state a lot more than others. In Bennington County, the number of permits issued may increase by more than six times if the current proposal remains unchanged, but the impact will probably be much smaller in Addison County.
Richard Phillips, owner of Vermont Field Sports in Middlebury, said that the proposed change hasn't earned much attention in the Addison County area. "I haven't heard anybody hollering about it yet in the store," Phillips said. "I don't think it'll do much in Addison County, really."
The Vermont Fish & Wildlife Department Board is considering issuing almost twice as many antlerless deer permits for the coming hunting season as were issued in 2007. The 14-member board of the department gave preliminary approval to issue 22,050 permits in an April vote. Last year, the department issued only 11,050 permits for antlerless deer during the nine-day muzzleloader season.
The board met again yesterday, and the final decision on any increase will probably not be made until August, according to Claude Rainville of Lincoln, Addison County's representative to the board. Rainville emphasized that the decision wasn't final and there would be chances for public input. "It's a lengthy process," he said.
Public hearings in Lyndonville and Rutland are planned on the issue. The Rutland hearing is scheduled for 7 p.m. on Tuesday, July 1, at the cafeteria of the Rutland Middle School at 67 Library Ave.
The board is considering the increase to control the size of the state's deer herd, which has apparently grown quickly in recent years. "We can't let the deer destroy their own habitat because of overpopulation," Rainville said.
Subscribe to Online Edition
Online PDF Print Edition
Copyright 2011 Addison Independent | 58 Maple Street, Middlebury, Vt. 05753 | All Rights Reserved
Site Development by Surf New Media