text:
CHARLESTON, S.C. (AP) - A federal judge will decide whether a $600 million deepening of the Savannah River shipping channel requires a pollution permit from the state of South Carolina before the work can begin.
The Georgia ports want the river deepened to handle larger ships that will be calling when the Panama Canal is deepened in two years.
But last month, conservation groups on both sides of the river separating the two states sued in South Carolina state court, saying a pollution permit is needed because deepening the 32-mile shipping channel will mean dredging up toxic cadmium in the river silt. The suit contends the material would be dumped on the South Carolina side of the river.
Earlier this month, the case was moved to federal court in Charleston and will be heard by U.S. District Judge Richard Gergel. Federal law allows such cases to be moved out of state court when a federal official or agency is being sued in its official capacity.
The U.S. Army Corps of Engineers has been granted an extension of time to answer the complaint, and that response is now due in mid-April.
The complaint was filed by the Southern Environmental Law Center, brought on behalf of the Savannah Riverkeeper based in Augusta, Ga., the South Carolina Coastal Conservation League and the South Carolina Wildlife Federation. It notes the corps' own draft environmental impact statement on the deepening indicated that there is cadmium in clays that would be removed as the river bottom is deepened.
The question of another South Carolina approval for the project is going before the state's highest court.
Earlier this month, the same conservation groups, along with the Conservation Voters of South Carolina, asked the justices to declare illegal a state Department of Health and Environmental Control water quality permit for the work.
The suit contends DHEC's water quality permit was illegal because state lawmakers gave authority over river dredging decisions to the South Carolina Savannah River Maritime Commission five years ago. DHEC agreed last week that the high court should resolve who decides the matter.
Lawmakers recently passed a law retroactively suspending DHEC's ability to make dredging decisions. Gov. Nikki Haley vetoed the law, but lawmakers easily overrode her veto.
Last year, Haley asked the DHEC board to hear Georgia's appeal of the water quality permit after the agency staff initially denied it. Georgia Gov. Nathan Deal earlier flew to Columbia to meet with Haley, and Haley said that Deal made a reasonable request and that she did not pressure the board for approval.
Minutes before the appeal was to be heard, the agency reached a settlement with the Georgia Ports Authority and Army Corps of Engineers. Without debate, the DHEC board then approved the settlement.
Copyright 2012 The Associated Press.


text:
Alternative formsEdit
- præsently (archaic)
presently (comparative more presently, superlative most presently)
- (now Britain, rare) Immediately, at once; quickly. [from 14thc.]
- ~1600, William Shakespeare, Hamlet, Act 3, Scene 2:
- Polonius: My lord, the queen would speak with you, and presently.
- The Bible: Matthew xxi. 19:
- And presently the fig tree withered away.
- 1603, John Florio, transl.; Michel de Montaigne, The Essayes, […], printed at London: By Val[entine] Simmes for Edward Blount […], OCLC 946730821:, Folio Society, 2006, Vol.1, p.219:
- the butler supposing the Wine had beene so carefully commended unto him for the goodnesse of it, imediately presented some unto the Pope, who whilest he was drinking, his sonne came in and never imagining his bottles had beene toucht, tooke the cup and pledged his father, so that the Pope died presently; and the sonne, after he had long time beene tormented with sicknesse, recovered to another worse fortune.
- ~1600, William Shakespeare, Hamlet, Act 3, Scene 2:
- Before long; soon. [from 15thc.]
- 1646, Thomas Browne, Pseudodoxia Epidemica, I.3:
- It […] is the greatest example of lenity in our Saviour, when he desired of God forgiveness unto those, who having one day brought him into the City in triumph, did presently after, act all dishonour upon him, and nothing could be heard but, Crucifige, in their Courts.
- 1907, Robert William Chambers, chapter I, in The Younger Set, New York, N.Y.: D. Appleton & Company, OCLC 24962326:
- But they had already discovered that he could be bullied, and they had it their own way; and presently Selwyn lay prone upon the nursery floor, impersonating a ladrone while pleasant shivers chased themselves over Drina, whom he was stalking.
- 1940, Raymond Chandler, Farewell, My Lovely, Penguin 2010, p.55:
- 'I shall presently be getting a call to tell me of that.'
- 1646, Thomas Browne, Pseudodoxia Epidemica, I.3:
- At the present time; now; currently. [from 15thc.]
- Sir Philip Sidney (1554-1586)
- The towns and forts you presently have.
- 1891, The Welsh Review, No.1 (November 1891). "A Word to the Welsh People." p.1:
- To all of you, therefore, who call Wales your motherland, whether you presently inhabit some other portion of the globe or breathe the air of your cloud-kissed country […].
- Sir Philip Sidney (1554-1586)
- (obsolete) With actual presence; in actuality. [~1600]
- Bishop Stephen Gardiner (1483-1555)
- His precious body and blood presently three.
- Bishop Stephen Gardiner (1483-1555)
Usage notesEdit
- Some older usage guides, especially for UK English, object to the sense meaning "now", though most major modern dictionaries do not.
in the near future

subset: commoncrawl


text:
FRITZ!Box 7490 Serwis - Baza wiedzy
AVM Content
Using an ISDN PBX with the FRITZ!Box
If you connect your ISDN PBX to the FRITZ!Box, the devices connected to the PBX can use all of the telephone numbers that were entered in the FRITZ!Box.
Requirements / Restrictions
- The ISDN telephone system must be suitable for use on an ISDN point-to-multipoint line.
Note:The configuration procedure and notes on functions given in this guide refer to the latest FRITZ!OS for the FRITZ!Box.
1 Configuring telephone numbers in the FRITZ!Box
First, configure all of your telephone numbers in the FRITZ!Box:
Configuring internet telephone numbers
- Configure your internet telephone numbers in the FRITZ!Box.
Configuring landline numbers
- Configure your landline number in the FRITZ!Box.
Configuring a mobile telephone number
- Configure your mobile telephone number in the FRITZ!Box.
2 Connecting the PBX to the FRITZ!Box
- Connect the PBX to the "FON S0" port on the FRITZ!Box.
3 Configuring the PBX in the FRITZ!Box
- Click "Telephony" in the FRITZ!Box user interface.
- Click "Telephony Devices" in the "Telephony" menu.
- Click the "Configure New Device" button.
- Enable the option "ISDN PBX", click "Next", and follow the wizard's instructions.
4 Configuring the extensions of your PBX
If you do not assign telephone numbers to the extensions of your PBX, then the main telephone number you configured in the FRITZ!Box is used to make outgoing calls. In addition, all of the extensions react to all incoming calls. Therefore, assign the desired telephone numbers to the extensions:
- In the PBX, define which numbers the extensions should react to when you receive calls and which number should be used to make calls. Enter the numbers in the PBX the way they are displayed in the settings for the ISDN PBX in the FRITZ!Box user interface (see fig.). If you assign an internet telephone number to an extension, and that number is identical to a landline number, then outgoing calls from this extension will be made over the internet.
Note:Sometimes a number may be too long for you to enter the complete number in the ISDN device. If this is the case, do not enter the entire number. Instead, enter as many of the last digits as possible.
Fig.: Settings for the ISDN PBX in the FRITZ!Box user interface
5 Disabling the energy-saving mode in the FRITZ!Box
The FRITZ!Box is equipped with a number of energy-saving mechanisms. For example, communication between the internal S0 bus and ISDN device is cleared when there is no active connection. Some ISDN devices have problems with this function. Therefore, disable this function in the FRITZ!Box if ISDN devices are having problems with establishing connections:
- Configure the telephone so you can send keypad sequences (sequences of symbols and numbers, such as *121#) and enter special characters such as * and # with it. On many telephones, you can configure this function in the menu "Operation at a PBX > Dialing options > Dial * and #".
Disabling the energy-saving mode
- Enter #966*1* on your telephone and press the call key (lift the receiver).
- Hang up again after about 3 seconds.
Note:You can reenable this function by entering #966*0*.


text:
J.D. Power insurance ratings are your trusted source for auto insurance ratings, home insurance ratings, life insurance ratings, health insurance ratings, business insurance ratings, and property insurance ratings derived from our comprehensive consumer studies. All insurance ratings are based on the opinions of a representative sample of consumers who have used or owned the product or service being rated and are therefore indicative of a typical buying experience.
Visit www.jdpower/CARS to research new and used cars >


text:
The 33-year-old dishes about her pushy parents with Rachael Ray on Friday
Bill and Hillary Clinton have very strong powers of persuasion. Just ask their daughter, Chelsea – she's feeling the pressure from both of them to have a baby.
The 33-year-old – who recently admitted that she'd like to become a mom in the next year – tells Rachael Ray on Friday's episode of her show that the former president and secretary of state are using strong-arm tactics on her.
"There is completely unapologetic pressure. In private and in public," she admits. "If one of my parents were sitting here, they would tell you without blinking an eye that it would make them the happiest thing on earth if I were to make them grandparents, and they would say it so effusively, and I would feel a bit of pressure."
But the Clintons didn't raise a pushover. Their little girl is standing her ground and will get pregnant when she feels the time is right.
"I want to ensure that my husband and I are in a place in our lives and in our working lives where we can provide that for our children without a doubt," she says.
In a segment in which she answered questions from viewers, the former first daughter also revealed where she had her first kiss. And despite living at 1600 Pennsylvania Avenue from the ages of 12 to 20, she didn't lock lips in the rose garden.
"It was not actually in the White House," Clinton admits. "[It was] in the boy who was going to become my boyfriend's basement."
"Mom and Dad just got a little too much information, I think," Ray joked.
Clinton also admitted that when she was a little girl that she was fascinated by space.
"I wanted to be an astronaut," she says. "The first sort of big present I remember getting from Santa Claus was quite a small telescope that I remember going into our backyard with my parents and figuring out how to assemble, and staring at the night sky, just for hours, with both of my parents."


text:
Schadenfreunde, as I understand the concept, is a kind of guilty pleasure one takes in contemplating the misfortune of another. Today, I experienced the inverse or perhaps the complementary emotion -- a bit of shame at contemplating my own good fortune.
I'm sure the Germans have a word for that too. They're very into shame.
You might ask why, that is, if anyone were reading this blog which there assuredly is not, but the question remains even if you do not exist to ask it. Well, the Senate passed the Budget Reconciliation bill today. I actually had taken the extraordinary step of calling each and every one of my congresscritters to discuss this bill with them. And while I don't have the clout to get to chat with a congresscritter directly, as a manager of a sizable employer back in the district, I was able to chat directly with their chiefs of staff and/or policy directors. The Reconciliation was important because it contained an important measure to freeze some scheduled cuts in Medicare reimbursement to physicians. All of our representatives and senators are democrats (and it really sucks to be in the minority), and we all agreed that this bill was a moral abomination because it also contained lots of cuts in Medicaid and other programs for society's vulnerable. So we chatted about how they hoped to block passage of this bill, and then perhaps the matter of Medicare and physician's reimbursement could be dealt with separately.
Anyway, the bill passed today, so we get more money, but the poor get screwed.
21 December 2005
What's the inverse of Schadenfreunde?
Schadenfreunde, as I understand the concept, is a kind of guilty pleasure one takes in contemplating the misfortune of another. Today, I experienced the inverse or perhaps the complementary emotion -- a bit of shame at contemplating my own good fortune.
Posted by shadowfax at 11:38 PM
4 comments:
It was a crazy day in Washington yesterday. Kudos for playing an active role. I've never really been active politically, with the exception of voting. There is so much more I should probably do.ReplyDelete
Very cool. Few people take that kind of inititave. I financially support a couple organizations that are basically lobbies, but calling and talking to someone is a step I've never taken.ReplyDelete
In the vein of civic duty and the less fortunate,there is a "reality TV" trend I would never have predicted, and is oddly cool. Have you seen some of these do gooder shows? Keeps reminding me that I should be volunteering in some capacity.
I'm a politics wonk. I admit it. There has never been a good excuse for me to get invovled before, other than the occasional letter or email regardign a pet cause, and occasional organizing meetings, caucuses, and donations. But I've been getting a little involved with the Emergency Medicine thing, both WRT medicare and also tort reform. It's more than a little appalling to be aligned more with the republicans on these issues. But it's also fun. And I can convince myself that this is not just self-interest lobbying because there really is a good cause -- the ER is the backbone of the social safety net, and we do a ton of uncompensated charity work -- but maybe that is self delusional.ReplyDelete
Of course, with the current administration, I'm getting progressively more interested in partisan politics across the spectrum of issues. Funny thing, that.
- Anonymous4/16/2006 10:36 PM
I think the word you're looking for is "Schadenfreude", not "Schadenfreunde"; I latter term would mean something like "shameful friends".ReplyDelete


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Computed tomography (CT) scanners have become more complex, procedures have become more sophisticated, data sets have become extraordinarily large, and ionizing radiation doses necessary to produce quality examinations continue to be questioned. Current research and information pursuant to safe performance of CT examinations for all age groups are the primary presentation points in this program. We discuss ionizing radiation dose as it applies to computed tomography, look at somatic effects, offer recommendations for better diagnostic performance, and offer suggestions for safer use of CT systems.
To find out if your facility has a subscription or to get information on how to become a subscriber, please contact us at firstname.lastname@example.com or call 1800 659 465.
By the end of this program, the viewer should be able to:
COURSE LENGTH: 1 Hour
ACCREDITATION TYPE: ASRT - Technologists
The target audience is CT
technologists and radiologists. Other medical personnel may also benefit from
viewing this program.


text:
Sept. 18, 2001
Santa Barbara, Calif. - The Schedule
Match No. 5
Wednesday, September 19, 2001 at 7:00 p.m.
UC Santa Barbara Gauchos vs. Westmont Warriors
at UCSB's Harder Stadium
Match No. 6
Sunday, September 23, 2001 at 2:00 p.m.
UC Santa Barbara Gauchos vs. San Jose State Spartans
at UCSB's Harder Stadium
UCSB Reignites Hot Rivalry With Westmont
The Gauchos will return home to start their eight match homestand against cross town rival and NAIA powerhouse Westmont. Last season, the Warriors came out victorious with a 2-0 win at Harder Stadium. The Warriors will enter the next chapter in the UCSB rivalry with a 3-0-2 record. Westmont, which was ranked seventh in the preseason NAIA poll, are hoping to keep their unbeaten streak alive after a 9-0 victory over CS Monterrey Bay and an 1-0 overtime win over Notre Dame de Namur. Westmont is lead by junior defender Ben Meek, who has scored two goals and three assists in only five matches. Junior forward Dana Weymouth and junior midfielder Mark Oehlman have each tallied three goals apiece. In the net for the Warriors, goalkeeper David Jay has allowed only one goal in 365 minutes of play.
Gauchos Play Host To 17th Ranked San Jose State
Despite starting the 2001 season with three straight victories, 17th-ranked San Jose State suffered its first loss on Monday night at the hands of California. The 3-2 defeat dropped the Spartans record to 3-1-0 before heading to Southern California to face Cal State Northridge before traveling to UCSB. San Jose State, whose leading scorer Lars Lyssand was ejected at Cal, currently holds first place in the Mountain Pacific Sports Federation. Lyssand leads the Spartans and the MPSF with four goals scored in an equal number of games. Goalkeeper Gilbert Vega, who is climbing the career shutouts records with seven, has allowed only .40 goals per match and has allowed one goal in 225 minutes of action
The Streak Is Over
After going undefeated in their first three matches of the season, UCSB lost its first of 2001 at St.Mary's on Monday night. The 1-0 loss dropped the Gauchos record to 3-1-0. UCSB had many chances to score recording 20 shots in the match. However, the stellar play of Gael's goalkeeper Kellan Wilson kept the Gauchos scorless. Wilson notched eight saves and his second shutout of the season. Rob Friend led the Gauchos with five shots, while Joe Hubay-Dies added four shots. Jon Apilado and Drew McAthy also tallied three shots apiece. Goalkeeper Dan Kennedy recorded three saves and allowed only his second goal in four matches.
With A Little Help From Our Friend
Only four matches into this young season, junior forward Rob Friend has emerged as the Gaucho's leading offensive threat. A native of Kelowna, British Columbia and a transfer from Western Michigan, Friend earned a starting forward position during the offseason. In his Gaucho debut, Friend tallied two assists, one on a game-winning goal, to lead the Gauchos to a 3-0 victory over Long Island in the first match of the Kappa Klassic. Only two days later, Friend scored the game-winning goal for UCSB in their 2-0 win over Illinois-Chicago in the second round of the tournament. Following his performance in the Kappa Klassic, Friend was awarded with Big West Player of the Week honors for the week of September 3rd. Friend continued on his offensive tear by scoring the game-winning goal in UCSB's 3-1 victory at San Diego State and lead the Gauchos with five shots in their 1-0 loss at St. Mary's. The Canadian National Team player currently leads the Big West in points (6), points per game (2.00) ,goals (2), assists (2), assists per game (.67) and game-winning goals (2). He is also tied for second in the conference in shots with 10 and in goals per game with .67. Friend also leads the Gauchos in points, goals, assists, shots and game-winning goals.


text:
You are here: Home > Prescription(RX) Drugs > M > Mannitol (B. Braun Medical Inc.)
mannitol injection
----------20% Mannitol Injection USP
20% Mannitol Injection USP is a sterile, nonpyrogenic solution of Mannitol USP in a single dose container for intravenous administration. It contains no antimicrobial agents. Mannitol is a 6-carbon sugar alcohol prepared commercially by the reduction of dextrose. Although virtually inert metabolically in humans, it occurs naturally in fruits and vegetables. Mannitol is an obligatory osmotic diuretic.
Each 100 mL contains:
Mannitol USP 20 g; Water for Injection USP qs
Administration of substantially hypertonic solutions (≥ 600 mOsmol/L) may cause vein damage. Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L.
The formula of the active ingredient is:
The EXCEL Container is Latex-free, PVC-free, and DEHP-free.
The plastic container is made from a multilayered film specifically developed for parenteral drugs. It contains no plasticizers. The solution contact layer is a rubberized copolymer of ethylene and propylene. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. The container-solution unit is a closed system and is not dependent upon entry of external air during administration. The container is overwrapped to provide protection from the physical environment and to provide an additional moisture barrier when necessary. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
The closure system has two ports; the one for the administration set has a tamper evident plastic protector and the other is a medication addition site. Refer to the Directions for Use of the container.
Mannitol Injection USP is one of the nonelectrolyte, obligatory, osmotic diuretics. It is freely filterable at the renal glomerulus, only poorly reabsorbed by the renal tubule, not secreted by the tubule, and is pharmacologically inert.
Mannitol, when administered intravenously, exerts its osmotic effect as a solute of relatively small molecular size being largely confined to the extracellular space. Only relatively small amounts of the dose administered is metabolized. Mannitol is readily diffused through the glomerulus of the kidney over a wide range of normal and impaired kidney function. In this fashion, approximately 80% of a 100 gram dose of mannitol will appear in the urine in three hours with lesser amounts thereafter. Even at peak concentrations, mannitol will exhibit less than 10% of tubular reabsorption and is not secreted by tubular cells. Mannitol will hinder tubular reabsorption of water and enhance excretion of sodium and chloride by elevating the osmolarity of the glomerular filtrate.
This increase in extracellular osmolarity effected by the intravenous administration of mannitol will induce the movement of intracellular water to the extracellular and vascular spaces. This action underlies the role of mannitol in reducing intracranial pressure, intracranial edema, and elevated intraocular pressure.
20% Mannitol Injection USP is indicated for:
Promotion of diuresis, in the prevention and/or treatment of the oliguric phase of acute renal failure before irreversible renal failure becomes established.
20% Mannitol Injection USP is contraindicated in patients with:
Well-established anuria due to severe renal disease.
In patients with severe impairment of renal function, a test dose should be utilized (see DOSAGE AND ADMINISTRATION). A second test dose may be tried if there is an inadequate response, but no more than two test doses should be attempted.
The obligatory diuretic response following rapid infusion of 20% Mannitol Injection USP may further aggravate preexisting hemoconcentration. Excessive loss of water and electrolytes may lead to serious imbalances. Serum sodium and potassium should be carefully monitored during mannitol administration.
If urine output continues to decline during mannitol infusion, the patient's clinical status should be closely reviewed and mannitol infusion suspended if necessary. Accumulation of mannitol may result in overexpansion of the extracellular fluid which may intensify existing or latent congestive heart failure.
Excessive loss of water and electrolytes may lead to serious imbalances. With rapid or prolonged administration of mannitol, loss of water in excess of electrolytes can cause hypernatremia. Electrolyte measurements including sodium and potassium are therefore of vital importance in monitoring the infusion of mannitol.
Osmotic nephrosis, a reversible vacuolization of the tubules of no known clinical significance, may proceed to severe irreversible nephrosis, requiring close monitoring during mannitol infusion.
Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid balance, electrolyte concentrations, and acid-base balance during parenteral therapy with a mannitol solution.
This solution should be used with care in patients with hypervolemia, renal insufficiency, urinary tract obstruction, or impending or frank cardiac decompensation.
The cardiovascular status of the patient should be carefully evaluated before rapidly administering mannitol since sudden expansion of the extracellular fluid may lead to fulminating congestive heart failure.
Shifting of sodium-free intracellular fluid into the extracellular compartment following mannitol infusion may lower serum sodium concentration and aggravate preexisting hyponatremia.
Mannitol administration may obscure and intensify inadequate hydration or hypovolemia by sustaining diuresis.
Electrolyte-free mannitol injection should not be given conjointly with blood. If it is essential that blood be given simultaneously, at least 20 mEq of sodium chloride should be added to each liter of mannitol solution to avoid pseudoagglutination. In no other instance should additions be made to 20% Mannitol Injection USP. The addition of sodium chloride to 20% mannitol solution may result in precipitation of mannitol. The final infusate should therefore be inspected for cloudiness or precipitation immediately after mixing, prior to administration, and periodically during administration.
Solutions of mannitol may crystallize when exposed to low temperatures. Concentrations greater than 15% have a greater tendency to crystallization. Inspect for crystals prior to administration. If crystals are observed, the container should be warmed by appropriate means to not greater than 60°C, shaken, then cooled to body temperature before administering. If all crystals cannot be completely redissolved, the container must be rejected. Administer intravenously using sterile, filter-type administration set.
Do not use plastic container in series connection.
If administration is controlled by a pumping device, care must be taken to discontinue pumping action before the container runs dry or air embolism may result. If administration is not controlled by a pumping device, refrain from applying excessive pressure (>300mmHg) causing distortion to the container such as wringing or twisting. Such handling could result in breakage of the container.
This solution is intended for intravenous administration using sterile equipment. It is recommended that intravenous administration apparatus be replaced at least once every 24 hours.
Use only if solution is clear and container and seals are intact.
Laboratory Tests
Although blood levels of mannitol can be measured, there is little if any clinical virtue in doing so. The appropriate monitoring of blood levels of sodium and potassium; degree of hemoconcentration or hemodilution, if any; indices of renal, cardiac and pulmonary function are paramount in avoiding excessive fluid and electrolyte shifts. The routine features of physical examination and clinical chemistries suffice in achieving an adequate degree of appropriate patient monitoring.
Carcinogenesis, mutagenesis, impairment of fertility
Long term studies in animals to evaluate the carcinogenic and mutagenic potential or the effect on fertility of 20% Mannitol Injection USP have not been conducted.
Teratogenic Effects
Pregnancy Category C. Animal reproduction studies have not been conducted with 20% Mannitol Injection USP. It is also not known whether 20% Mannitol Injection USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. 20% Mannitol Injection USP should be given to a pregnant woman only if clearly needed.
Nursing Mothers
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when 20% Mannitol Injection USP is administered to a nursing woman.
Pediatric Use
Safety and effectiveness in children below the age of 12 years have not been established.
Usage in Children
Dosage requirements for patients 12 years of age and under have not been established.
Geriatric Use
Clinical studies of 20% Mannitol Injection USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation and hypervolemia.
Extensive use of mannitol over the last several decades has produced recorded adverse events, in a variety of clinical settings, that are isolated or idiosyncratic in nature. None of these adverse reactions have occurred with any great frequency nor with any security in attributing them to mannitol.
The inability to clearly exclude the drug related nature of such events in these isolated reports prompts the necessity to list the reactions that have been observed in patients during or following mannitol infusion. In this fashion, patients have exhibited nausea, vomiting, rhinitis, local pain, skin necrosis and thrombophlebitis at the site of infection, chills, dizziness, urticaria, hypotension, hypertension, tachycardia, fever and angina-like chest pains.
Of far greater clinical significance is a variety of events that are related to inappropriate recognition and monitoring of fluid shifts. These are not intrinsic adverse reactions to the drug but the consequence of manipulating osmolarity by any agency in a therapeutically inappropriate manner. Failure to recognize severe impairment of renal function with the high likelihood of nondiuretic response can lead to aggravated dehydration of tissues and increased vascular fluid load. Induced diuresis in the presence of preexisting hemoconcentration and preexisting deficiency of water and electrolytes can lead to serious imbalances. Expansion of the extracellular space can aggravate cardiac decompensation or induce it in the presence of latent heart failure. Pulmonary congestion or edema can be seriously aggravated with the expansion of the extracellular and therefore intravascular fluid load. Hemodilution and dilution of the extracellular fluid space by osmotic shift of water can induce or aggravate preexisting hyponatremia.
If unrecognized, such fluid and/or electrolyte shift can produce the reported adverse reactions of pulmonary congestion, acidosis, electrolyte loss, dryness of mouth, thirst, edema, headache, blurred vision, convulsions and congestive cardiac failure.
These are not truly adverse reactions to the drug and can be appropriately prevented by evaluation of degree of renal failure with a test dose response to mannitol when indicated; evaluation of hypervolemia and hypovolemia; sodium and potassium levels; hemodilution or hemoconcentration; and evaluation of renal, cardiac and pulmonary function at the onset of therapy.
Too rapid infusion of hypertonic solutions may cause local pain and venous irritation. Rate of administration should be adjusted according to tolerance. Use of the largest peripheral vein and a small bore needle is recommended. (See DOSAGE AND ADMINISTRATION.)
The physician should also be alert to the possibility of adverse reactions to drug additives. Prescribing information for drug additives to be administered in this manner should be consulted.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
In the event of a fluid or solute overload during parenteral therapy, reevaluate the patient's condition, and institute appropriate corrective treatment.
Larger doses than recommended may result in increased electrolyte excretion, particularly sodium, chloride, and potassium. Sodium depletion can result in orthostatic tachycardia and/or hypotension and decreased central venous pressure. Chloride metabolism closely follows that of sodium. Potassium deficit can impair neuromuscular function and cause intestinal dilatation and ileus.
Mannitol may cause pulmonary edema or water intoxication if urine flow is inadequate. See WARNINGS.
This solution is for intravenous use only.
The total dosage, concentration, and rate of administration should be governed by the nature and severity of the condition being treated, and the patient's fluid requirement and urinary output. The adult dosage ranges from 50 to 200 g in a 24-hour period, but in most cases an adequate response will be achieved at a usual dosage of approximately 100 g/24 hours. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 mL/hour. Lower mannitol concentrations and solutions containing sodium chloride are useful in preventing dehydration and electrolyte depletion. This outline of administration and dosage is only a general guide to therapy.
Dosage requirements for patients 12 years of age and under have not been established. As with adults, dose is dependent on weight, clinical condition, and laboratory results. Follow recommendations of appropriate pediatric reference text.
Test Dose
A test dose of mannitol should be given prior to instituting therapy for patients with marked oliguria or those believed to have inadequate renal function. Such test doses may be approximately 0.2 g/kg body weight (about 75 mL of a 20% solution) infused in a period of 3 to 5 minutes to produce a urine flow of at least 30 to 50 mL/hour. If urine flow does not increase, a second test dose may be given. If response is inadequate, the patient should be reevaluated.
Prevention of Acute Renal Failure (Oliguria)
When used during cardiovascular and other types of surgery, 50 to 100 g of mannitol may be given.
Treatment of Oliguria
The usual dose for treatment of oliguria is 100 g administered as a 20% solution.
Reduction of Intraocular Pressure
A dose of 1.5 to 2.0 g/kg as a 20% solution (7.5 to 10 mL/kg) may be given over a period as short as 30 minutes in order to obtain a prompt and maximal effect. When used preoperatively the dose should be given one to one and one-half hours before surgery to achieve maximal reduction of intraocular pressure before operation.
Reduction of Intracranial Pressure
Usually a maximum reduction in intracranial pressure in adults can be achieved with a dose of 0.25 g/kg given not more frequently than every six to eight hours. An osmotic gradient between the blood and cerebrospinal fluid of approximately 10 mOsmol will yield a satisfactory reduction in intracranial pressure.
Adjunctive Therapy for Intoxications
As an agent to promote diuresis in intoxications, mannitol is indicated. The concentration will depend upon the fluid requirement and urinary output of the patient.
Measurement of glomerular filtration rate by creatinine clearance may be useful for determination of dosage.
It is recommended that 20% Mannitol Injection USP be administered through a blood filter set to ensure against infusion of mannitol crystals.
When a hypertonic solution is to be administered peripherally, it should be slowly infused through a small bore needle, placed well within the lumen of a large vein to minimize venous irritation. Carefully avoid infiltration.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Use of a final filter is recommended during administration of all parenteral solutions, where possible.
This solution is intended for intravenous administration using sterile equipment.
The use of supplemental additive medication is not recommended.
20% Mannitol Injection USP is supplied sterile and nonpyrogenic in EXCEL® Containers. The 500 mL and 250 mL containers are packaged 24 per case.
Directions for Use of EXCEL Container
Do not admix with other drugs.
Caution: Do not use plastic container in series connection.
To Open
Tear overwrap and remove solution container. Check for minute leaks by squeezing solution container firmly. If leaks are found, discard solution as sterility may be impaired.
NOTE: Before use, perform the following checks:
Preparation for Administration
PRINCIPAL DISPLAY PANEL - 500 mL Container Label
20% Mannitol
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Each 100 mL contains: Mannitol USP 20 g
pH: 5.3 (4.5-7.0)
Sterile, nonpyrogenic. Single dose container.
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WARNING: Do not admix with other drugs.
Dissolve any mannitol crystals by heating (≤60°C) and shaking;
Recommended Storage: Room temperature (25°C).
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EXCEL is a registered trademark of B. Braun Medical Inc.
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PRINCIPAL DISPLAY PANEL - 250 mL Container Label
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Each 100 mL contains:
pH: 5.3 (4.5-7.0)
Sterile, nonpyrogenic. Single dose container
Do not use in series connection.
Warning: Do not admix with other drugs.
Dissolve any mannitol crystals by heating
Recommended Storage:
Rx only
The EXCEL Container is Latex-free, PVC-free,
EXCEL® is a registered trademark of B. Braun
B. Braun Medical Inc.
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text:
My body becomes tense in empathy. I have to breathe this out. I try to stay with them without going under.
Do you know what I'm talking about?
Let's agree that we have all experienced anxiety, and let's also agree that it has never done anyone any good, ever. It's useless. When we have it, we don't want it.
It's like tag: you're it until you get rid of it. In tag, you get rid of it by dumping it on someone else. Anxiety is different. We don't get rid of it, we see it, and that seeing causes anxiety to leave of its own accord.
When people say they are anxious, they are quite correct. They have become anxiety, and everything they think, say, and do will be anxious. We might be able to so arrange our thoughts and our circumstances to briefly not experience anxiety, but this is not different than an asthmatic taking deep draughts from an inhalator. The symptoms are temporarily gone, but the asthma is still there, hiding in some interior smoke and card shop.
To be free from anxiety requires that we see it, not just understand it. To understand anxiety is to have our friend say, "Oh, don't worry, that's not going to happen." When we have become anxiety, our friend's advice is ridiculous. We are certain that what they say won't happen, will. The the basis of our anxiety is the certainty-unfounded-that something is going to happen, and it is going to be bad for us.
Anxiety is our internal interpretive response to a situation, real or imagined, which leads us to believe that something bad is going to happen. We might be four days away from our rent being due, without any money. Anxiety responds like this: We won't get any money. We will be homeless. We will lose all our friends. We will die next Wednesday.
A circus tent could be going up ten feet from us and we wouldn't see it. We would see, instead, the anxiety-induced hallucinations unfolding in our mind. This is all we would see.
Anxiety isn't real. It is imaginary. This is what we must see. We can't just understand it. We can't just have our friend say, "Hey, your anxiety is just imaginary."
We have to be able to see that our response has nothing to do with anything. It exists purely within our own imagination: part fear, part insecurity, and part past decisions about how life is.
May everyone be at peace, in love, and know their most perfect Self.
His new book, The Sacred Hub (The Crossing Press, ISBN: 0-89594-837-0), is available through the bookstores nationwide.


text:
Munchkin Watch: Two snaps for Arnaud Clement for snapping a six-match losing streak that dated all the way back to this year's French Open. Now he's into the second round of the IF Stockholm Open after defeating fifth-seed Andreas Beck 6-4, 6-2 — this, after successfully getting through qualifying and earning a spot in the main draw.
Buy: Clement's wearing the Short Sleeve Solid Super Dry Lacoste polo in black. Check out all the colors (starting at $51.99) at lacoste.com.
(image via Getty)
Tags: stockholm open


text:
Zipcar is a membership-based, car sharing company that serves over 673K members with a fleet of over 9K vehicles in North America and Europe. The company enjoyed a successful IPO in April 2011 and posted its first two profitable quarters over the second half of 2011. The car sharing company grew its membership by 25% in 2011, leading to 30% higher revenues compared to the previous year. An improved mix of revenues and access to cheaper vehicle financing also resulted in better margins despite a net loss for the full year. As margins continue to pick up, the company is on its way to post its first annual profit in 2012.
Aside from competing with traditional rental companies and car-sharing services like Connect by Hertz, Enterprise's WeCar, UHaul's UCarShare and City Car Share, it also faces competition from new low-cost, peer-to-peer (P2P) car sharing services like RelayRides and GetAround.
See our full analysis of Zipcar here.
Market Potential
The global car sharing market could exceed $10 billion by 2020, and Zipcar is currently the leading market player in the segment with first-mover advantage and significant brand cache. During 2011, its membership grew by 25% in North America and Europe. The company has turned aggressive in its European expansion after completing the integration of Streetcar's operations in the U.K. in 2011. It recently acquired a majority stake in Barcelona's Avancar and appointed its first president of Zipcar Europe.
Frost & Sullivan research estimates that by 2016, the North American car sharing market could surpass 4.4 million members and $3 billion and the European car sharing market could surpass 5 million members and 3 billion euros. We currently estimate Zipcar Membership in North America could reach 2 million and Zipcar Europe membership could cross half million over the next decade.
Improving Margins With Cheaper Fleet Financing
Car sharing is a highly capital intensive business in which fleet costs constitute the biggest expense. Zipcar has significantly reduced its vehicle acquisition costs over the past year by shifting from leasing vehicles to purchasing vehicles through Asset Backed Securitization facility that provides it access to low-cost vehicle financing. It recently doubled the ABS facility to $100 million to fund its domestic fleet expansion in 2012. Lower cost for vehicle financing will further help Zipcar's bottom-line.
Fleet costs currently constitute 66% of Zipcar's revenues compared to 71% in 2009. This reduction happened as Zipcar started phasing out vehicles under its operating lease in the U.S. and replaced them with vehicles purchased through the ABS facility. The number of vehicles under operating leases fell from 90% in 2009 to 50% in 2011 and is expected to continue to decline.
3 Key Risks Ahead
Competition Turning up the Heat
Zipcar presently occupies the largest market share in the car sharing market exceeding 50% in North America and has established a brand synonymous with car sharing. However, going forward, we expect the company to face stiff price competition from car rental giants like Hertz and Enterprise that have launched their own car-sharing segments like Connect and WeCar with relaxed membership fees and one-way rental facilities to lure customers.
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It also faces new competition from up and coming low-cost, P2P car sharing services like RelayRides, GetAround, Sprideshare and Jolly Wheels. By investing in smart web interfaces, online marketplace, smartphone apps and car-kits to enable keyless entry, P2P players such as RelayRides and GetAround are making credible attempts to match Zipcar's accessibility and convenience with the cost advantage of not requiring to purchase or rent a fleet. Zipcar has also recently invested in Wheelz, a peer-to-peer car sharing company targeting college campus communities, acknowledging the potential of P2P sharing business model.
Slower Market Growth
We currently estimate Zipcar Membership in North America to reach 1.9 million by the end of the Trefis forecast period. However, there could be a 20% downside to the Trefis price estimate if market growth is slower and Zipcar Membership in North America manages to reach just 1.5 million by the end our forecast period due to slower market growth and stiff competition with other car sharing companies like Hertz Connect, Enterprise's WeCar and UCarShare.
Weaker Margin Expansion
Another risk to the company could be slower improvements in profitability owing to the capital intensive nature of the car sharing business. We currently estimate Zipcar's EBITDA Margin to gradually increase to 23% by the end of the Trefis forecast period. There could be a 25% downside to the Trefis price estimate if the company fails to improve its EBITDA margins beyond 20% by the end of the Trefis forecast period due to a delay in reaching profitability due to high fixed costs as well as the likelihood of price wars due to increasing competition.
We have a $22 Trefis price estimate for Zipcar.
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text: Could This Be the Year of Unprecedented Corn Yields? July 15, 2014 09:05 AM Tweet TAGS: Marketing, Overseas December 18, 2014 By Jo Windmann AgWeb Senior Web Producer Email There is plenty of potential for record crops, according to the latest USDA Crop Progress report. The national corn crop is in better condition this year than the previous year, and week. USDA says that 76% of the nation's corn is rated good to excellent, which is a point higher than last week and a whopping 10 points higher than this time last year. And Missouri leads the pack with 84% of the state's corn rated good to excellent. According to the report, 34% of the 2014 U.S. corn crop is silking, which is right on average. Soybean conditions also showed significant improvement over the previous year with 72% rated good to excellent, which his 7 points higher in comparison. Soybeans are also blooming ahead of schedule with 41% in the blooming stage. This is a 17 point leap from last week and 4 points ahead of average. With these estimates, the question remains: How good could the U.S. corn crop be? Ag economist Scott Irwin says that in the last five decades we have never had one of those super-high average yields when you have such extreme precipitation in June. He goes on to add that this doesn't mean it can't happen, but it would be unprecedented. Could this be that year? AgDay's Clinton Griffiths says that only time and USDA will tell. Watch the full AgDay Crop Progress report. Want more? AgWeb readers are sharing fresh crop production insights every day. Click here to join the conversation, or to start your own. Back to news


text:
Building off of my previous post on suburban poverty, I briefly touched on the aspect of infrastructure. I mentioned that municipalities and transit agencies (really all government agencies) will be hard pressed to keep up their existing infrastructure, let alone create new infrastructure in a financially sustainable way. Much has been written on this topic, and I don't have much new to add. Yet, I'm astonished to learn how much this country can tolerate when it comes to poor infrastructure. In urban planning and transportation circles, it has been common to note that it would take a major accident or catastrophe to get this country to embark on a program for infrastructure renewal. And yet, we've had two catastrophic incidents just in less than 10 years: Hurricane Katrina and the New Orleans levee breaches in 2005 and the Minneapolis bridge collapse in 2007. Even today, with $5.00 a gallon gas a distinct possibility this year and with record transit ridership, we refuse to invest in infrastructure that will make our cities fundamentally better and more sustainable places.
So how does this sorry state of affairs affect us?
According to the Urban Land Institute's recent report, Infrastructure 2011: A Strategic Priority, we may see the following:
- Tax Increases: User fees are likely as tolls and transit fares increase to meet operating costs. Additional utility fees and traffic fines too.
- Deterioration: Local governments will fund essential capital projects but may be forced to abandon others. We already are seeing this with states allowing paved roads to revert to gravel.
- Deterioration will result in service interruption and will affect mobility. This is exactly what happened with the Minneapolis bridge collapse.
economic and political climate around infrastructure, I believe we need to focus any future growth in built up areas where infrastructure is already in place. Developing on greenfield sites without and transportation and/or utility infrastructure is absolutely idiotic given the realities. We need to see land use densities and mixed use types increase around transit stations to leverage the existing transportation infrastructure already in place. We also need to see infill development on brownfield sites where there is existing transportation and utility infrastructure. And, as difficult to fathom as this may be, we need to reconsider the utility of maintaining the infrastructure of much of the suburban experiment. Much of it, I suspect, is simply not sustainable.


text:
So, that was that then.
A pretty active year, altogether, for revolution, natural disasters and the distinctly postmature death of genocidal fuckheads, England became the No.1 cricket team in the world (though at time of writing are doing their level best to unbecome the same) and somewhere in the foreground, the Murdoch media empire did its best impression of being irredeemably crippled even though it had done nothing worse than scraping its knee whilst bending over to spy on on a stranger's balls.
Odd, apparently. Mishappen. Prone to huge shifts in form and mass in rapidly changing climates.
On a personal level, 2011 saw me unemployed and missing out on a grand total of three jobs because of a tour of Australia (you try explaining to potential employers the difference between 'holiday' and 'work' when you're so desperate for money that you'd eat at McDonald's if someone paid you enough*) and am searching still, at times with hope, at times without. I ran a few half marathons (in the middle of the night), got some way through writing my first bullshit book (also in the middle of the night) and read so much Ancient and Military History that at times I felt I should be taking a chariot to rehearsal instead of a bus.
Band wise, well, we're still here, and delighted to be doing it.
Final track listing for the album (after some revisions and a quick remix for 'goals in slow motion' the masters, I'm happy to say, are being run off tomorrow) is as follows. None of these titles are working titles, incidentally. Release date, sadly (saddest for us, mind – we started recording it LAST FUCKING JUNE) is still to be confirmed.
1. sheena is a t-shirt salesman
2. failed olympic bid
3. beneath the waves an ocean
4. cosmo's ladder
5. city of exploded children
6. goals in slow motion
7. camp cappuccino
8. polymers are forever
9. robocop 4 - fuck off robocop
10. sorry dad, i was late for the riots
11. i am the least of your problems
12. a guide to men
13. anchor
14. rubber animals
15. notes on achieving orbit
Having had a break from the thing over the course of the last couple of months I can exclusively reveal that, according to me (and I trust me, implicitly) it sounds as good as I remember it. I don't want to talk the thing up because that seems desperate but I will say this – we're very, very proud, a feeling which I'm allowing to linger until the end of next month when it will be doubtless replaced by the hollow anger of the ignored and jealous. Just kidding(*2)
We're still deciding on 'singles' and, although that term seems less relevant nowadays (how about 'promotional device for radio and youtube'?) we would very much like to release them on 7" single with the obligatory exclusive b-sides and all that jazz (nb. no actual jazz). My question to you (here and on twitter/facebook) – how much is a fair price? We want this to be something you can hold, look at and, if needed, comfort, but we'd rather not go losing money we don't have in the interim.
So, in review ...
Australia was, in general, very good fun. Perth(*3) and Sydney were a delight whilst Brisbane and Meredith revelatory considering the distinct lack of sleep which preceded both shows. Only Melbourne felt strange and, despite our best efforts, lacked the atmosphere that we've come to expect from one of our favourite cities in the world. Perhaps it was just the way it felt from the stage but we felt as if we played twice as well as earlier in the year and got half the response. Proof, if proof be need be(*5) that there's no science to rock n'roll. The three UK shows were good fun as well, particularly London - despite the faintly preposterous airs and graces of Hoxton Bar and Kitchen it's actually a pretty good sounding room and we had a fine night, once the double van breakdown and most miserable in-house sound-guy(*6) in the world were taken on and vanquished to the four corners of our collective memories.
Right, I must fly. More to follow very, very soon(*7), including show and single news, record store day and some bumpf about South by South West, which it turns out we are playing after all.
(leon) best
ps. How do you like your eggs in the morning? I like mine to exist.
(*) I will happily eat a McDonald's meal if you reimburse my stomach and soul to the tune of £5,000. (*1)
(*1) an admission - twice on our tour of Australia I was forced (partly by a lack of funds but also because I was trapped in an airport and didn't feel like paying £10 for a sad, wet sandwich) to eat a grilled chicken burger from Hungry Jacks, which, for my non-Australian readers, is Burger King in all but name. Although it didn't taste too bad I could tell that the chicken had been thoroughly depressed even before being electrocuted by a robot then thrown into a seeded bap.
(*2) no, I'm not.
(*3) about half an hour before going on in Perth we were watching the pretty-damn-good-despite-the-
(*4) who reminded us a little of our good friends Science Bastard, musically if not hair-wise.
(*5) thanks 'The Day Today'.
(*6) anyone who is in a touring band will know that this is quite an accolade.
(*7) in the next few days. Promise.


text:
A woman in India has filed for divorce from her husband because he had not updated his relationship status on Facebook to "married" instead of "single," The Next Web is reporting.
The couple had been married for only two months, but the woman is already looking to nullify the – arranged – marriage over her husband's Facebook gaffe.
For his part, the man claims he simply forgot to update his status because he was so busy with family and his furniture business post-wedding.
This Asian Age report sheds a little more light. It's an arranged marriage and apparently, this kind of thing happens frequently:
The Telugu couple had an arranged marriage just two months ago. … The judge has given the two parties six months to undergo counselling.
There are several cases like this one of couples wasting the time of the courts by asking for marriages to be invalidated for the flimsiest of reasons. Altercations over who makes the tea and refusal to take an in-law's phone call have snow-balled into divorces. Family court lawyer Anita Salabh Jain says couples are not serious about a long-term relationship. "They just want to make insignificant issues culminate into something serious and drag the spouse to court. The sole issue of not changing one's marital status in social networking sites can't be accepted as a ground for divorce. The court will try to bring the parties together," she said.


text:
Hi everyone
I'm after some advice regarding my Campag Eurus 2 way fit wheels bought in Sept 2015.
A rear spoke broke last weekend and my wife has taken it in to be replaced. Today she received a phone call to say that all the nipples are seized and that they will need to be replaced. The cost quoted is $100 labour, $1.50/nipple and $7/spoke for any spokes that may brake (which they said is likely) as they change the nipples over.
When my wife let them know that the wheel was under warranty (& was also purchased from the bike shop), she was told that the nipples are considered to be 'moveable parts' and therefore not covered under warranty.
I could live with the cost if one nipple was seized, however if every nipple on the wheel has seized and needs to be replaced then surely this is due to a fault and therefore should be covered under warranty? Looking at the Campagnolo warranty, I can't find any mention of exclusions wrt the wheels.
Does anyone have any experience with this, before I follow things up further tomorrow?
many thanks in advance.


text:
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17 June 2013
Texas becomes fifth state to ban indoor tanning for minors under 18
WASHINGTON, D.C. (June 17, 2013) —
Texas has joined California, Vermont, Oregon, and Nevada by passing legislation that prohibits minors under the age of 18 from indoor tanning. This announcement comes shortly after the U.S. Food and Drug Administration proposed stricter regulations on indoor tanning beds, as well as a strong recommendation against the use of tanning beds by minors under the age of 18.
"The American Academy of Dermatology Association is proud to have supported this legislation and commends the state of Texas for joining the fight against skin cancer, including melanoma, the deadliest form of skin cancer," said board-certified dermatologist Dirk M. Elston, MD, FAAD, president of the American Academy of Dermatology Association. "Melanoma incidence rates have been increasing for the last 30 years, with the most rapid increases occurring among young, white women, the most common users of indoor tanning beds. Prohibiting minors' access to indoor tanning stops this behavior before it can become a habit that continues into adulthood."
Legislation prohibiting the use of indoor tanning beds by minors under 18 passed both the Texas Senate and House in May. Gov. Rick Perry did not sign or veto the bill within the 20-day period. Therefore, the bill automatically became law. The ban will go into effect on Sept. 1, 2013.
Support for the ban was provided by the American Academy of Dermatology Association, the Texas Dermatological Society, the Texas Pediatric Society, AIM at Melanoma, the American Society for Dermatologic Surgery, the American Cancer Society Cancer Action Network, the Dermatology Nurses Association, and the Joanna M. Nicolay Melanoma Foundation.
More than 3.5 million skin cancers in more than 2 million people are diagnosed annually. It is estimated that one in five Americans will develop skin cancer in their lifetime and more than 3,930 new cases of melanoma will be diagnosed in Texas in 2013. The risk of developing melanoma increases by 75 percent for individuals who have been exposed to UV radiation from indoor tanning, and the risk increases with each use. Since 2.3 million teens tan indoors in the United States annually, restricting teens' access to indoor tanning is critical to preventing skin cancer.
In an effort to increase the public's understanding of skin cancer and motivate people to change their behavior to prevent and detect skin cancer, the Academy launched the SPOT Skin Cancer™ public awareness initiative. Visit the SPOT Skin Cancer™ website — www.SpotSkinCancer.org — to learn how to perform a skin self-exam, download a body mole map for tracking changes on your skin, and find free skin cancer screenings in your area. Those affected by skin cancer also can share their story via the website and download free materials to educate others in their community.


text:
Salim R necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 67 diseños de 9 diseñadores freelance.
Hadiya is the Arabic word for Gift. Our company has the ambition to become the reference online gift store in France and in Europe for "modern Muslim families". The three axes of our development are: promotion of generosity, great buying experience, and top customer service level. The concept is declined into a range of products that include traditional gifts and more innovative packages that include personalized gifts and gift boxes.
All products will be marketed using the brand name Hadiya and derived brand names such as Hadiyabox. The company name is Hadiya Company.
The tagline (in French for now) is: « La solution à toutes vos envies de cadeaux».
Hadiya targets Muslim communities in France and in Europe in priority and consumers are more likely to be in the 20-40 age group. Teenagers and elderly people will be targeted as secondary consumer niches and eventually all shoppers are most welcome!
- Hadiya in 3 versions (color, black & white, and full version with tagline underneath) + 2 derived logos for Hadiyabox (voucher concept) and Hadiya company
- able to sit on different color backgrounds
- reference colors are Green , gold and white (variations accepted)
- the Arabic word for gift shall be included in the logo using a calligraphic font (see examples) and an original shape (ribbon, heart shape, door top, etc.),
- logo shall incorporate a strong reference to Arab and Muslim cultures using the traditional door shape, the crescent, sand dunes, etc...
- logo shall be self-meaning and the reference to gifts shall be explicit using for example a gift box, a ribbon or a heart.
- proposed shapes are provided in the attachment and shall be used as reference. Radically different proposals are of course possible.
- Logo shall be elegant but modern and stylish
- The logo of the voucher concept (Hadiyabox) shall be derived from the main logo with some specifics related to the git voucher concept. A simplified logo for the full company name (Hadiya Company) shall also be proposed
- logo should be provided in layered psd and png files
Enjoy !!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Our experts make their playoffs, Super Bowl and award predictions, with more thoughts on what we can expect in 2013
Peter King's Predictions
|Wild Card
|Super Bowl
|Wild Card
|1. Patriots
|1. 49ers
|Bengals def. Texans
|Saints def. Packers
|2. Broncos
|2. Falcons
|Broncos def. Bengals
|49ers def. Saints
|3. Bengals
|3. Packers
|Patriots def. Broncos
|Patriots def. Seahawks
|Seahawks def. 49ers
|4. Colts
|4. Giants
|Patriots def. Ravens
|Seahawks def. Falcons
|5. Ravens
|5. Seahawks
|Ravens def. Colts
|Seahawks def. Giants
|6. Texans
|6. Saints
Player Awards
MVP—Tom Brady
If I'm right, and the Patriots win the AFC's top seed, this will be Brady's shining moment, getting the Pats to the top of a tough conference with virtually entirely new skill players.
Offensive Player of the Year—Chris Johnson
Defensive Player of the Year—Geno Atkins
Offensive Rookie of the Year—Eddie Lacy
Defensive Rookie of the Year—Tyrann Mathieu
Awards like this go to guys who make lots of plays. Mathieu has been diving all over Cards' practices, making circus interceptions and proving to the front office that it made a smart choice with this risky pick.
Coach of the Year—Sean Payton
Comeback Player of the Year—Robert Griffin III
Greg Bedard's Predictions
|Wild Card
|Super Bowl
|Wild Card
|1. Patriots
|1. Seahawks
|Steelers def. Ravens
|Giants def. Falcons
|2. Texans
|2. Packers
|Patriots def. Chiefs
|49ers def. Seahawks
|3. Steelers
|3. Giants
|Steelers def. Patriots
|49ers def. Steelers
|49ers def. Giants
|4. Chiefs
|4. Buccaneers
|Steelers def. Texans
|Giants def. Packers
|5. Broncos
|5. 49ers
|Chiefs def. Broncos
|49ers def. Buccaneers
|6. Ravens
|6. Falcons
Player Awards
MVP—Ben Roethlisberger
Big Ben has long been underrated for his regular-season play. If the Steelers surprise and take the AFC North, it's time to give him the award.
Offensive Player of the Year—Calvin Johnson
Defensive Player of the Year—Terrell Suggs
Offensive Rookie of the Year—Tavon Austin
Defensive Rookie of the Year—Star Lotulelei
Coach of the Year—Andy Reid
Comeback Player of the Year—Brian Cushing
Darrelle Revis is the runaway preseason favorite, but Cushing will do more.
Jenny Vrentas' Predictions
|Wild Card
|Super Bowl
|Wild Card
|1. Patriots
|1. Packers
|Texans def. Chiefs
|Saints def. Seahawks
|2. Broncos
|2. 49ers
|Patriots def. Steelers
|Packers def. Falcons
|3. Texans
|3. Saints
|Broncos def. Patriots
|Packers def. Broncos
|Packers def. 49ers
|4. Ravens
|4. Giants
|Broncos def. Texans
|49ers def. Saints
|5. Steelers
|5. Falcons
|Steelers def. Ravens
|Falcons def. Giants
|6. Chiefs
|6. Seahawks
Player Awards
MVP—Tom Brady
Offensive Player of the Year—Adrian Peterson
Defensive Player of the Year—Luke Kuechly
Offensive Rookie of the Year—Tavon Austin
Defensive Rookie of the Year—Ziggy Ansah
Coach of the Year—Bill Belichick
Are there really people who think the Patriots will have a down year? You'd have to credit the coach if this is yet another Patriots-level-of-good season, in the wake of one of their star young players being indicted for murder.
Comeback Player of the Year—Alex Smith
Smith was the NFL's most accurate passer last season, with a completion percentage above 70 percent—until he was sidelined with a concussion in November, and Colin Kaepernick ran away with the 49ers' starting QB job. A fresh start with a talented Chiefs roster, and a head coach who has long admired Smith, could be the recipe for a comeback.
Robert Klemko's Predictions
|Wild Card
|Super Bowl
|Wild Card
|1. Texans
|1. Seahawks
|Ravens def. Bengals
|Redskins def. Lions
|2. Broncos
|2. Falcons
|Colts def. Texans
|Seahawks def. Redskins
|3. Ravens
|3. Lions
|Colts def. Broncos
|Seahawks def. Colts
|Seahawks def. Falcons
|4. Patriots
|4. Giants
|Broncos def. Ravens
|Falcons def. 49ers
|5. Colts
|5. 49ers
|Colts def. Patriots
|49ers def. Giants
|6. Bengals
|6. Redskins
Player Awards
MVP—Peyton Manning
And what a swan song it will be. For the 16 weeks before it gets too cold in the Rockies for a man of advancing years and receding strength to properly grip a football, Manning will treat us to one final dance with greatness. Good night, sweet Sheriff.
Offensive Player of the Year—Marshawn Lynch
Defensive Player of the Year—Geno Atkins
Offensive Rookie of the Year—DeAndre Hopkins
Defensive Rookie of the Year—Matt Elam
No disrespect to Ed Reed, one of the all-time greats, but Elam will remind Ravens fans of what they've been missing in either safety position for a year now.
Coach of the Year—Chuck Pagano
Comeback Player of the Year—Brian Cushing
Your Super Bowl Predictions
Andy Benoit's Ten Things to Watch
Rise of "two tights"
New England's success with Rob Gronkowski and Aaron Hernandez over the past two years opened a lot of eyes. The two dynamic, movable chess pieces created glaring matchup problems and invaluable flexibility with formations. The duo is no more, obviously, but there will be others popping up around the league. The Bengals, Cowboys, Titans, Eagles, Cardinals and Rams all made significant offseason moves to give themselves a dual tight end offense. Couple this with the handful of teams that already had that, and roughly half the league will regularly be playing "two tight" in 2013.
Read-option smackdown
We'll see how many offenses stick with the read-option once unblocked defensive ends figure out they can drill the quarterback even when he hands off.
More pistol
Even if the read-option abates, pistol sets should surge. Offenses are realizing that pistol is essentially a quicker version of the shotgun, only with more play-action capabilities. It doesn't always require the quarterback to run. Heck, even Peyton Manning's Broncos experimented with the new set in August.
More S – P – R – E – A – D
NFL offenses will continue to stretch horizontally. Some will even do it on nearly a fulltime basis. Four intriguing storylines from four different teams that are transforming their once-traditional systems into spreads: A.) How will the Rams use Tavon Austin? B.) How will Chip Kelly's play designs function on NFL fields, where tighter hashmarks leave less perimeter space to work with? C.) Can Philip Rivers prosper by throwing more quick-hitter type passes? D.) Can Jay Cutler?
A premium on man coverage
Offenses will continue to spread, and they'll continue to use more hurry-up. The hidden benefit of hurry-up is it's a great way to combat complex defensive looks. When the ball is snapped immediately, the defense doesn't have time to disguise anything and is forced to play reactively.
Schematically, man coverage is the simplest way to defend spread sets and the hurry-up. It nullifies the spacing issues that most spread designs aim to exploit and requires minimal presnap communication. What's more, in man coverage, defenders can pick up receivers immediately off the line of scrimmage, as opposed to a few yards downfield. That combats the quick strike throws that spreads and hurry-ups are largely built on.
Breakout stars
On offense, it's Packers wideout Randall Cobb. Mike McCarthy will employ a variety of tactics—including presnap motion and backfield alignments—to get the shifty, versatile third-year pro in space. Expect Cobb to have around 1,500 yards from scrimmage as the fulcrum of Green Bay's offensive attack. On defense, it's Everson Griffen. The fourth-year Vikings defensive end has sensational speed and pliable body control. He can play anywhere along the defensive front. If afforded enough playing time, Griffen will have a 15-sack season.
Super Bowl stepbacks
Losing key passing targets Anquan Boldin and Dennis Pitta and overhauling half the defense (with some good changes but also some bad) will prevent the Ravens from defending their Lombardi Trophy. 7-9 seems a likely record. The other Harbaugh-coached team is also poised to take a step back. The losses of Randy Moss and Delanie Walker—two middle-of-the-road contributors but highly unique mismatch creators—put more strain on a passing game that's led by a young star who, granted is supremely talented, but far less polished than people realize. 10-6 seems likely in San Francisco.
Big changes on D in Big D
It's can be difficult to transition from a multipronged hybrid 3-4 scheme to a more traditional 4-3 zone scheme. That's what the Cowboys, who replaced defensive coordinator Rob Ryan with aging legend Monte Kiffin, are aiming to do. If Kiffin makes this a Seahawks type 4-3 zone (which would mean hybrid press-man concepts for outside corners), the Cowboys can flourish. If he makes it a Tampa-2 style zone, they could flounder.
High-flying Falcons
It's hard to envision anyone stopping this offense. Julio Jones is poised to become a top-5 caliber receiver. All the other weapons are back, only with the running back position upgraded from Michael Turner to Steven Jackson. Orchestrating it all is burgeoning star Matt Ryan and coordinator Dirk Koetter, one of the shrewdest play-callers in football.
Worst to first?
In each of the last 10 seasons, at least one team has won its division after finishing last the previous year. The contenders this season: Buffalo, Cleveland, Jacksonville, Kansas City, Philadelphia, Detroit, Tampa Bay and Arizona. If forced to pick one, the choice here would be Cleveland. The Browns could have a playmaking defense, and their offense, though deprived of aerial weapons and depth, at least has the right style of players for Norv Turner's highly accomplished system.
Odds and Ends
Most intriguing storyline
I'm interested to see if Chip Kelly can resuscitate the flagging career of Michael Vick. And I'm interested to see how many plays Kelly can squeeze out of a 60-minute football game. Eighty? Ninety? With his penchant for running a hurry-up offense ("I think his offense is going to look a lot like the K-gun the Bills ran with Jim Kelly," said Tony Dungy, whose son played for Kelly at Oregon), Kelly is going to keep it fun. I've said this is going to be the most interesting coach to watch come out of college football since Jimmy Johnson to Dallas in 1989, and I believe he'll turn the Eagles around. Maybe not this year, but he's too smart to take longer than a year to figure out how to win in the pro game. —Peter King
Breakout player to watch
Jared Cook. After spending his first four seasons jailed by quarterback play (Vince Young, Kerry Collins, Matt Hasselbeck, Jake Locker), the rest of the NFL will finally get to see the full potential of a player who has enormous talent that has been underutilized. At 6-6 and 248 pounds with long arms, Cook has a huge catch radius down the field, and the speed to turn short passes into long gains. He's a matchup nightmare—too fast for linebackers, too big for defensive backs—yet the Titans could never take advantage. Rams offensive coordinator Brian Schottenheimer will, especially in the red zone, where Cook should get a ton of targets. —Greg A. Bedard
Team that will surprise, for good or bad
Detroit Lions. Watching the Packers against the Seahawks in the third week of the preseason, specifically with an eye on Bryan Bulaga's replacement at left tackle, David Bakhtiari, solidified my feeling that the Lions will win the NFC North. They've got the kind of defense that can now keep up with Green Bay, especially if Jason Jones continues to play like a top-15 end and Louis Delmas can stay on the field and off the trainer's table. Reggie Bush will diversify the offense, Ryan Broyles will come back from his second ACL tear to have a strong second half, and Jim Schwartz will keep his job. Mark it eight, dude. —Robert Klemko
Toughest schedule
Atlanta Falcons. By playing the Jets, the Falcons get one easy win, but even the Bills should be better on Dec. 1 at the end of the season and with E.J. Manuel back. Their own NFC South will be improved and a dogfight. Add in the Patriots, Seahawks, Packers, Redskins and 49ers, and you have a brutal slog from start to finish. —Greg A. Bedard
Easiest schedule
Kansas City Chiefs. If they get good quarterback play out of Alex Smith, the Chiefs have winnable games until Week 7 against the Texans, and that's at home. The toughest games down the stretch will be two against the Broncos, on the road at the Redskins and home to the Colts. Very manageable if the Chiefs can build some momentum. —Greg A. Bedard
Best game of the season
49ers at Redskins, Nov. 25. A couple years down the road, will Colin Kaepernick vs. RG3 be the NFC's version of the AFC's Tom Brady vs. Peyton Manning battle royales? This will be the first time these two bright young faces of the NFL play each other. Each charmed the NFL last season with his talent by arm and by foot; they'll be even more fun to watch together. —Jenny Vrentas


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As my regular readers will remember, my last trip to Chicago was less than satisfactory when I played Medinah. I had a much better trip this year.
So, I'm checking into my hotel and my cheerful mid-western bellman asks me as he carries my clubs into the room, "So where are you playing?"
Me: "Chicago Golf," I said, expecting him to be impressed.
Bellman: "Where is that?"
Me: "Wheaton."
Bellman: "Never heard of that one, is it new?"
I just let it drop. Clearly he was not into golf. Chicago Golf (ranked #31 in the world) is not a new golf course. In fact, quite the opposite. Chicago Golf was one of the five founding member clubs that formed the U.S.G.A. The Chicago Golf Club is credited with having the first 18 hole course in America - although it is not the current course. The original course of the Chicago Golf Club was located nearby in Belmont. The Chicago Golf Club was founded in 1892 by our friend Charles Blair Macdonald. Before he moved to New York and helped organize the Links Club and The National Golf Links of America, Macdonald lived in Chicago. Although Macdonald was born in Canada, he grew up in Chicago and was a successful businessman and a member of the Chicago Board of Trade.
As it turns out, Chicago Golf Club is a club of many firsts - not only did it establish the first 18 hole course in the U.S., it was the first to adopt out-of-bounds as a rule in the United States, and it was the first club that organized a "caddy-shack" for its caddies to stay in. At the time Chicago built its first 18 hole course, many clubs in the U.S. were still experimenting with courses of various length - some built six hole courses, others nine, and still others 12 hole courses.
C.B. Macdonald designed the original golf course here in Wheaton in 1895. Macdonald was a famous slicer of the ball so he built the course to favor a slice. The course sits on roughly 200 acres on a rectangular piece of property. As you can see from the original course layout pictured below, the holes essentially are routed in two loops that run clockwise around the property. There is an old, unused polo field in the middle that now serves as a very large driving range.
Consistent with Macdonald's design philosophy, the course doesn't have many trees. Macdonald didn't think trees made a good hazard. He was heavily influenced by his love of the game as it was played in Scotland and preferred firm and fast conditions without trees. The primary defense of the golf course is the wind, which can blow quite strong here without any trees protecting it. It is a different sensation you get standing on the first tee at Chicago Golf Club. It doesn't really look like most other American courses, most of which are tree-lined (unless they are links-style and near the water). Chicago is a links-style golf course, but it was not built on classic links-style land. Thus, it is a bit of an enigma in the world of golf. The picture below was taken from the 4th fairway and shows how a typical vista looks at Chicago Golf with the wide-open look.
The golf course was redesigned in 1923 by Macdonald's protege Seth Raynor. The course has a definite Raynor feel to it, especially the horse-shoe greens that wrap around many of the greens. Their combined designed has many of the signature holes they have become famous for designing including a Road Hole, Redan Hole, Biarritz Hole, Punchbowl Hole and two Cape Holes.
Chicago Golf Club offers a difficult start. The first four holes contain the one, three and five handicap holes. Typical of some of the mounding and hills present throughout the course, see the mounds off the 2nd fairway below ("Road" Hole).
Mounds off second fairway
The third hole is a "Biarritz" hole and plays over 220 yards to a green with a false front and swale in front. It's a very good and demanding golf hole. Notice the classical bunkering around this hole.
3rd hole "Biarritz" from the tee
The fourth hole is one of the two "Cape" holes, the other being the 14th. This hole has a high elevated green with a green that is difficult to hold as it has a false front that feeds balls back onto the fairway.
4th hole green and fairway bunker
The 7th Redan hole is a very good rendition of a Redan hole. Probably because Chicago Golf doesn't get as much play as other world-class courses with Redans like Shinnecock, National and North Berwick, it is often overlooked as a good Redan hole. Consistent with Chicago's big greens generally, it probably has the largest green of all the classic Redans.
A big Redan - 7th hole
I found the defining characteristics of Chicago Golf to be: a links-style feel due to the absence of trees, large greens and the distinctive horse-shoe bunkers. There are many "deceptions" present also, such as the false fronts on many greens and bunkers placed so that they look to be closer to the green than they really are. Several of the greens (the 14th and 18th in particular) were squared off; that is, they were designed so that the beginning of the green is cut at a 90 degree angle to the fairway. I've never seen this before on any greens.
Chicago Golf Club has a lot of good golf history. It has hosted four U.S. Amateur Championships, two Walker Cups and three U.S. Opens - 1897, 1900 and 1911. Bobby Jones holds the course record of 66, set in 1928 at the Walker Cup. Chicago Golf Club is not as well known as Macdonald's other masterpiece, The National Golf Links of America. This is because unlike The National, Chicago doesn't do outings, and it has a very small and private membership. It has the smallest membership I have heard of for a world-class course - only 125 members.
The general feel at Chicago Golf Club is intimate but not flashy. Like at Pine Valley, there are no frills. This is just about golf. The clubhouse is comfortable and not extravagant. It is all very understated.
Punchbowl Green - 12th hole
The 14th hole, the second "Cape" hole, I also enjoyed quite a bit. It is one of the many greens that has a horse-shoe bunker. Other holes with horse-shoe bunkers are the 7th, 9th, 10th, 13th and 14th. Macdonald, a very successful businessman, built a "mansion" in Wheaton. It is visible on your left as you stand on the 14th tee here. It is a big white house with columns on the porch.
14th horse-shoe bunker
8th hole horse-shoe bunker
The Chicago Golf Club has one of the best caddy programs I have ever seen. Taking a caddie is pretty much mandatory. The polite young mid-western kids that serve as caddies wear distinctive red bibs with the Chicago Golf logo on them.
This is also the third time in as many months I have bumped into C.B. Macdonald in my travels. He looked down at me intently from his perch in the giant painting in the C.B. Macdonald room at The Links Club in New York. He gave me a suspicious glare in the library at The National Golf Links of America where his big portrait again looks down at you and a life-size statue looms in the back of the room. And finally, between the pro-shop and locker-room at Chicago Golf is another statue of Charlie, making his presence felt once more.
If you appreciate history and tradition in this great game, playing Chicago Golf is a real treat, although with only 125 members, getting onto this gem is about as difficult as any course in the world.
Interested in learning the methods I used to play all these spectacular golf courses around the world? then my forthcoming book may be of interest, in details how a mortal golfer may be able to do the same. The book is available from Barnesandnoble.com and Amazon.com. Click on the image of the book below to order on Amazon:


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What is happening in Europe? Where is it going? What's the future of the Eurozone? Will the Euro survive? How will Eurozone economics affect the global economy? What does it all mean for the rest of us? While no one has a crystal ball to foretell the future, there are currents and trends that may indicate the direction events may take. Jacques Mistral has been a keen observer of the Eurozone from many vantage points; come discover what insights his experience reveals.
The Honors Program is proud to welcome Jacques Mistral as a Helen L. DeRoy Visiting Professor in Honors. An economist with wide international experience in the public and private sectors, Professor Mistral has been the Economic advisor to the Prime Minister of France, an Executive Vice President with the AXA group, a major international institution, and a special advisor to the French Institute of International Relations (IFRI-Paris). He is also a senior fellow of the Brookings Institution, and a visiting professor at Nanjing University.
Register here for the reception (5-7p, Perlman Honors Commons, G421 Mason Hall). The lecture, itself, is open.
Jacques Mistral


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Document Type
- Article (2) (remove)
In this paper we generalize the notion of method for proofplanning. While we adopt the general structure of methods introducedby Alan Bundy, we make an essential advancement in that we strictlyseparate the declarative knowledge from the procedural knowledge. Thischange of paradigm not only leads to representations easier to under-stand, it also enables modeling the important activity of formulatingmeta-methods, that is, operators that adapt the declarative part of exist-ing methods to suit novel situations. Thus this change of representationleads to a considerably strengthened planning mechanism.After presenting our declarative approach towards methods we describethe basic proof planning process with these. Then we define the notion ofmeta-method, provide an overview of practical examples and illustratehow meta-methods can be integrated into the planning process.
In this article we formally describe a declarative approach for encoding plan operatorsin proof planning, the so-called methods. The notion of method evolves from the much studiedconcept tactic and was first used by Bundy. While significant deductive power has been achievedwith the planning approach towards automated deduction, the procedural character of the tacticpart of methods, however, hinders mechanical modification. Although the strength of a proofplanning system largely depends on powerful general procedures which solve a large class ofproblems, mechanical or even automated modification of methods is nevertheless necessary forat least two reasons. Firstly methods designed for a specific type of problem will never begeneral enough. For instance, it is very difficult to encode a general method which solves allproblems a human mathematician might intuitively consider as a case of homomorphy. Secondlythe cognitive ability of adapting existing methods to suit novel situations is a fundamentalpart of human mathematical competence. We believe it is extremely valuable to accountcomputationally for this kind of reasoning.The main part of this article is devoted to a declarative language for encoding methods,composed of a tactic and a specification. The major feature of our approach is that the tacticpart of a method is split into a declarative and a procedural part in order to enable a tractableadaption of methods. The applicability of a method in a planning situation is formulatedin the specification, essentially consisting of an object level formula schema and a meta-levelformula of a declarative constraint language. After setting up our general framework, wemainly concentrate on this constraint language. Furthermore we illustrate how our methodscan be used in a Strips-like planning framework. Finally we briefly illustrate the mechanicalmodification of declaratively encoded methods by so-called meta-methods.