text:
DIOR NEW PANAREA TOTE BAGCategories:Other Brands
Oh, have you heard about Dior recently?
Yes? No?
They have re-designed the Panarea Tote and released a newer version around February/March. But let's talk from the start, how was the older version actually?
We have always loved the Panarea Tote Bag because the Canvas was extremely durable. Even after three years of use with care, this bag still looks like new, fresh from the store. Some people compare it to the Louis Vuitton Neverfull coated canvas leather, which is basically also very durable.
If you have felt and seen a Louis Vuitton Neverfull bag, you will instantly notice the extra thin leather. You might also be worried that it breaks, that's why a good alternative was the Panarea Bag. It has similar spacious but the strap is thicker and thus carrying becomes more comfortable.
Now let's move on to the newer Panarea Tote:
The upgraded version of the Dior Panarea Tote bag is released for the Spring Summer 2014 Collection. This bag is made from Rosato Canvas and the iconic 'Cannage' stitching is entirely different. It's more flat, modernized and structured compared to the older version. They have even changed the D.I.O.R. charm color, which was in the past in silver and now they are following the color of the bag.
The older Panarea Bag is quilted while the new one is more flat. It also wrinkled when you use it, unlike the newer version.
Now let's get to the details:
The new Dior Panarea Tote as well as the older version are both available at Dior boutique.
Update as per june 2016: the older Panarea is not longer in the boutique.
Dior Panarea Bag in Medium size: 35 x 29 x 17 in cm
Dior Panarea Bag in Large size: 40 x 31 x 18 in cm
comnum(0) tbcount(0) tbcount(250)
STREET SNAPS: NEW DIOR PANAREA TOTECategories:Other Brands
What is Dior doing?
Where is Dior going?
Last week, we sat down together and talk extensively about the new Dior Panarea Tote Bag and how it changed from the old and what details have been changed, you remember?
Then we asked the community for their opinion, we published two images: the Dior Panarea Tote old version and the Dior Panarea Tote new version. So how did our community respond?
Many fashionista's preferred the older version and one woman said: 'The new Panarea Tote looks like the Louis Vuitton Neverfull Bag, and I already got one Neverfull'.
Now I am baffled and thinking by myself: 'was it a gamble or did they asked their fans whether it's a good thing to upgrade the Panarea Tote or not?'
But anyways, let's keep the facts together. I want to share a conversation I had with Azreen, one of our friend and community member:
Message 1: 'Alex. I was in Paris & Rome few days ago, the old version of panarea is no longer in the boutique'.
Two and a half months ago, we were told that Dior boutique was still selling the old and the newer version of the Panarea Tote. I guessed they made a slow transition and the ultimate goal is to sell the new Panarea and discontinued the older version.
The purpose of this post was to share some life-pictures of the latest and the newest Dior Panarea Tote. Though we shared some juicy model-pictures last week, I belief they are not good enough. What's better than a real picture with no special effect and no photoshop.
Oh yes, and if you need the prices, please go to Dior Panarea Tote Details.
comnum(0) tbcount(0) tbcount(277)
Dior Panarea Tote Bag DiscontinuedCategories:Other Brands
The wonderful Panarea Tote Bag, which has been on the menu of Dior for a longtime. The fans were loving it because of its timeless cannage stitching and the roomy interior. And we are talking about the original Dior Panarea tote bag of course, if you know what I am saying.
And above all, this bag was generously priced compared to other Dior handbags, you could get your very own for €850 euro or $1200 USD for the medium size. And the large size was only €100 euro or $100 USD more in cash.
Then after 2014, Dior made a stunning move, the updated the Panarea Bag which is totally different than the original one. And well, we were not sure what to say because some ladies were loving it and others want the old-one back.
The biggest different between the original version and the 2014 version is the look. The 2014 version was thinner and while it looked more modern, it was also flat.
But here's the big news. We noticed something different on Dior's official website and that is… they removed the Dior Panarea Bag from the handbag list. So we were shocked, they're not going to discontinue the bag right?
And so we did a little investigation, it turned out that its true. This bag is slowly being phased out of the boutiques. And perhaps, perhaps when you're still hunting for one or its on your wish list, go ahead and grab one as soon as possible.
Sad story. We adore the Dior Panarea Bag.
comnum(0) tbcount(0) tbcount(323)
DIOR SMALL PANAREA TOTE BAGCategories:Other Brands
Just in case you didn't know this – the Dior Panarea Tote Bag is also available in 'small' size. This is the new Panarea Bag, we've discussed this issue many times. Some fashion ladies still love the previous version and others do prefer the newest version.
READ: Before and After 2014 Panarea Tote Bag
The main difference is the canage stitching – the older version is more alive, the newest is a bit flat but much more modernized. And instead of silver DIOR charm, they have changed into match the color of the bag.
The big change has to do with the functionality – the new Panarea Tote Bag is much more lighter in weight and like I said earlier…more modern. It's made with Canvas and the latest 'Small' size gives you even more choices.
You will love the Small Panarea if you're a shorty or because you want an extra bag whenever you don't 'NEED' or feel like to carry large bags. I love this tote because it's a compact bag that can store a lot of essentials.
Also there is an internal zip pocket inside.
Dior Small Panarea Tote Bag
Size: 31 x 25 x 15 cm
Price: €850 euro, £800 GBP
Tags: bag Dior Tote Small PANAREA


text:
Unusual breath odors are common in kids. Typically there isn't anything to worry about, but there are some breath odors that indicate an underlying problem.
In children smelly breath that persists throughout the day is most often the result of mouth-breathing, which dries out the mouth and allows the bacteria to grow. Children who consistently breathe through their mouths might have colds, sinus infections, allergies, or enlarged tonsils or adenoids blocking the nasal passages, so a visit to the pediatrician is in order. Thumbsucking or sucking on a blanket can also dry out the mouth.
Here is a list of some very uncommon, but telltale, odors (mostly from Mace, Goodman, Centerwall, et al: The child with an unusual odor. Clinical Pediatrics 15:57-62, 1976).
Unusual Breath Odors:
- Acetone (fruity smell) – diabetes or acetone, alcohol, phenol, or salicylate ingestion
- Ammonia – some types of urinary tract infections, or kidney failure
- Asparagus – eating asparagus (very unusual in children;>))
- Bitter almonds – cyanide poisoning
- Cat's urine – odor of cats syndrome (beta-methyl-crotonyl-CoA-carboxylase deficiency)
- Celery – Oasthouse urine disease
- Dead fish – stale fish syndrome (trimethylamine oxidase deficiency)
- Fresh-baked bread – typhoid fever
- Foul – tonsillitis, sinusitis, gingivitis, lung abscess, dental cavities, tonsil stones, or gastroesophageal reflux (some of these are actually quite common)
- Garlic – arsenic, phosphorus, organic phosphate insecticides, or thallium poisoning
- Horse-like (also described as mouse-like or musty) – phenylketonuria
- Rancid butter – odor of rancid butter syndrome (hypermethionemia and hypertyrosinemia)
- Raw liver – liver failure
- Sweaty socks – odor of sweaty feet syndrome (Isovalryl CoA dehydrogenase deficiency)
- Sweaty socks – odor of sweaty feet syndrome II (Green acyldehydrogenase deficiency)
- Violets – turpentine poisoning
Three-year-olds often stuff items in their noses, and then forget about them. When my son Kevin was three, he put five peas up his nose before anyone found out! Watch for the combination of smelly breath and a smelly, yellow nasal discharge — especially from one nostril. You and I might not think of stuffing peas up our noses, but three-year-olds think outside the box!

subset: commoncrawl


text:
March, 2008
We conducted two main areas of investigation. One was to study the impact of intensive dance education on higher cognition, including attention and biological motion perception abilities (Part 1). The second was to study the impact of extensive music education in childhood on learning a second language in adulthood (Part 2).
To explore the impact of intensive dance education on higher cognition, we undertook behavioral, brain imaging, and genetic studies. This included the development and pilot-testing of tools for identifying and differentiating expert dancers from non-dancers (and expert musicians and non-musicians). We also assessed dancers and non-dancers' performance on language and other cognitive tasks behaviorally, as well as while they underwent functional Near Infrared Spectroscopy (fNIRS) brain imaging. This brain imaging system detects changes in concentrations of blood oxygen levels that are associated with neural activity in the brain's cerebral cortex. We also developed software for standardizing the analysis and interpretation of fNIRS data, which has been tested in several laboratories.
Artistic education and expertise, such as in dance or in music, requires highly skilled motor control and the ability to selectively attend to, inhibit, and select appropriate sensory cues (such as when performing in a group). Our behavioral studies revealed that dancers were significantly more accurate than non-dancers on an attentional task. This finding suggests that early dance education may positively transfer to other cognitive areas, such as the ability to selectively focus attention and resist interference from competing signals.
Our behavioral studies showed that dancers also were faster on a Biological Motion Perception task. This finding suggests that early dance education benefits the processing of biological motion and benefits the speed of short-term memory processing of motion stimuli. In a separate experiment of dancers and non-dancers, in which both behavioral and fNIRS data were collected, we found a similar pattern.
To study possible genetic influences on these observed differences between dancers and non-dancers, as well as possible genetic influences on a person's likelihood of pursuing arts education, we identified seven candidate genes that might help to explain such differences. Our research to date on four of the seven candidate genes has shown only one possible relationship, supporting the hypothesis that differences in higher cognitive performance between dancers and non-dancers may be due to their education in the Arts rather than to a genetic predisposition. Research on the remaining three genes is ongoing.
... we examined the possible genetic influences on individuals' higher cognitive task performance and their likelihood of pursuing arts education. In Part 2 of our research, we tested the hypothesis that monolingual expert musicians would learn a second language better than matched non-musicians. This hypothesis is based on findings that musicians have enhanced selective attention on particular higher cognitive tasks, and learning another language involves the ability to attend to one language, inhibit the other, and rapidly switch between them. We studied monolingual English-speaking students enrolled in introductory Italian or Spanish classes, who were tested at the beginning and end of the academic term.
Musicians (those who received early extensive and continued music education) were compared to non-musicians on English language performance, new language performance, cognitive attentional processing, end-of-term self-evaluation, and class final grade. While the two groups showed no differences in general academic performance measures, or on cognitive attentional assessments, we found that the musicians exhibited significantly increased second language performance (greater improvement in expressive fluency and competence) compared to non-musicians. These results suggest that there may be an enduring cognitive advantage afforded by early and extensive music education on adult learning of a new language in an instructional setting.
The overarching goal of the Dana Foundation's Arts and Cognition Consortium is to understand the impact of intensive education in the Arts on the human brain – especially regarding the acquisition and learning of other core content knowledge. For the past three years, the Petitto Laboratory has addressed this question by studying: 1) the impact of intensive education in dance on higher cognition, including attentional and biological motion perception abilities (Part I); and, 2) the impact of extensive music education in childhood on learning a second language in adulthood (Part 2).
We used a variety of populations (e.g., dancers and musicians) and advanced techniques in brain imaging and human genetics. Our methods included the use of behavioral measures, and of the new functional Near Infrared Spectroscopy (fNIRS), a state-of-the-art brain imaging tool that is ideally suited for use in studies of higher cognition. Additionally, as an important design innovation, we conducted crucial co-registration validation checks of the fNIRS system with MRI/anatomical scans.
In the third funding year, we cast an additional exciting lens on our research questions by adding a third level of scientific analysis, the Genetic level, whereupon we examined the possible genetic influences on individuals' higher cognitive task performance and their likelihood of pursuing arts education. Together, our research program offers innovative advances by bringing to bear a trilogy of three core levels of analysis to assess the impact of intensive education in the Arts on the human brain: mind, brain, and genetics.
Artistic education and expertise (e.g., dance or music) requires highly skilled motor control and the ability to selectively attend to, inhibit, and select appropriate sensory cues, such as when performing in musical groups (e.g., Bever & Chiarello, 1974; Keller, 2001; Large & Jones, 1999; Schellenberg, 2005). Here, we tested the following "transfer of learning" hypotheses: Extensive education in the Arts may yield higher cognitive executive function advantages during the processing of other non-arts information (tested in our Dance study described below)—and/or during the learning and processing of other non-Arts knowledge (our Music and Language Learning study below; referred to as the Music study).
... the fNIRS system ... comes with no standard means for enabling cognitive neuroscientists to analyze its data output. Immediately below is a brief summary of Part I research during Years 1 and 2, including (i) innovations, (ii) key personnel/collaborations, and (iii) results. Extensive detailed discussion of these studies was provided previously. Thereafter, we describe our third-year research, a Mind-Brain-Genetic study of dancers versus non-dancers. At the close of this section is a list of the Tangible Products emanating from year three of this research, while similar lists from the first two years were provided in earlier reports. Thereafter, we briefly summarize Part 2 of the research, the Music Study, which explored the impact of extensive music education in childhood on learning a second language in adulthood. This study was described in detail in earlier reports.
Year 1: Dance Research Design and Methods
Petitto and team both designed and extensively piloted all: (i) Dance/Music screening and background questionnaires (to be used as one of the standardized tools to identify and differentiate expert, compared to novice, experimental groups); (ii) language screening and background questionnaires; and, (iii) language and cognitive tasks to be administered both behaviorally and during brain scanning. Additionally, Petitto and team completed the (i) scripting, filming, and editing of the experimental video clips to be used for the Dance study, and (ii) creating/designing of the selection criteria for differentiating expert compared to novice participants, as another key tool to establish participant groups. Petitto and team then began recruiting, screening, and studying participants for both the Dance and Music studies, and they also started data analyses for the Music study.
Key Personnel
Professor Laura-Ann Petitto, graduate student Ioulia Kovelman, and undergraduates Rachael Degenshein, Ryan Gramacy, Aekta Shah. We further held several outside meetings with Dartmouth College Professor Scott Grafton and graduate student Emily Cross (Dana consortium members). Importantly, other Dana consortium collaborations that were invaluable during the first two years of our research included consultation with Professor John Jonides (University of Michigan), who provided feedback on and input to our criteria for "expert" vs. "novice" participant groups. Professor Jonides also shared his Stimulus Response Compatibility (SRC) task with us. Further, Professor Michael Posner (University of Oregon) generously shared his Flanker Task/attention network task.
Year 2: Dance Research Design and Methods
Petitto and team completed the behavioral part of the Dance study, the Music study, and also completed all of the data analyses for both of these studies. Further, Petitto and team received a new fNIRS brain imaging system, and completed piloting of the fNIRS brain imaging part of the Dance study. While the fNIRS system has outstanding brain imaging and recording capabilities, remarkably, the system comes with no standard means for enabling cognitive neuroscientists to analyze its data output. Therefore, it was necessary to search for and hire a new Post-Doctoral Fellow, Dr. Mark Shalinsky, an electroneurophysiologist, to write software that would allow us both to analyze and to interpret the fNIRS system data. Dr. Shalinsky, with Petitto and Ioulia Kovelman, created and tested the new software, which was subsequently tested across several major fNIRS labs over 2006-2007 (Year 3).
... dancers were significantly more accurate than non-dancers on an attentional task ... We have submitted and revised a paper on this important "first-step" research activity to an international journal, in which we describe this new universal analysis program to analyze/interpret the data that the fNIRS system records. Cognitive neuroscience labs throughout the world that utilize fNIRS can use this analysis system. We also completed MRI/anatomical co-registration with fNIRS, to ensure high confidence in the neuroanatomical precision of our fNIRS probe placements.
Professor Laura-Ann Petitto, Post-Doctoral Fellows Dr. Melody Berens and Dr. Mark Shalinsky, and graduate student Ioulia Kovelman (see also Year 1 above).
As important background to our Year 3 research, our completed behavioral studies of dancers versus non-dancers revealed that dancers were significantly more accurate than non-dancers on an attentional task (p < .03). This finding, in turn, suggested that early dance education does benefit (that is, may positively transfer to) other domains of higher cognition, such as attentional processing, or more specifically, resistance to interference from competing signals, compared to participants who were not educated in the Arts.
We also found that dancers were faster on the Biological Motion Perception Task (p < .001). This finding suggests that early dance education benefits both biological motion processing and working memory of biological motion stimuli, in terms of the speed with which these stimuli are processed.
Part 1: "Mind-Brain-Gene" Dance Study Year 3
Innovations—Genetics (Genotyping Analyses)
To achieve the goal of studying possible genetic influences underlying observed performance differences on higher cognitive tasks in dancers versus non-dancers, as well as possible genetic influences on the likelihood of pursuing arts education, we collaborated with Dana consortium scholars Drs. Kevin Dunbar and Michael Posner.
Year 3 Key Personnel
Professor Laura-Ann Petitto, Post-Doctoral fellows Dr. Melody Berens and Dr. Katherine White (Petitto Lab), Dr. Ioulia Kovelman (now at MIT, John Gabrieli's Lab), Dr. Mark Shalinsky (now at Harvard/MGH, David Boas' Lab) and research assistant Douglas McKenney (now at Jerusalem University). Invaluable assistance and consultation about specific genes that might be associated with specific higher cognitive processes were provided by Drs. Kevin Dunbar and Michael Posner. Moreover, Dr. Dunbar also reviewed the Petitto team's proposed list of genes to study and offered important feedback that led to our final list of genes under investigation. We remain grateful to these scholars for their wisdom and time.
Indeed, to answer this question we needed to tackle, head-on, the elusive decades-old question of nature versus nurture.As discussed (above) in the summary of Year 1 and 2 Dance study results, we discovered significant performance differences on select higher cognitive tasks in persons with extensive education in the performing arts (dancers) versus those with minimal or no education in the performing arts (non-dancers). One exciting hypothesis that followed from these findings—one of the core hypotheses being tested by the Dana Arts and Cognition Consortium—is that such group differences derived from the impact of education in the Arts on the brain, and its positive transfer to the acquisition/learning and processing of other core content knowledge.
The tantalizing unanswered question from the Petitto team's Year 1-2 Dance Study findings, however, was this: Were such group differences specifically due to one group's extensive education in the arts versus the other group's lack of education in the arts, or were the group differences due to other biologically/genetically-based self-selection factors? Indeed, to answer this question we needed to tackle, head-on, the elusive decades-old question of nature versus nurture. Was it the sustained education—the environmental experience—with the arts that rendered dancers with a greater "cognitive edge" over non-dancers? Or, was it just that people who ended up being dancers were born with a complex composite of genetic predispositions—or "nature"— that generally afforded them select higher cognitive capacities, which, in turn, yielded a greater likelihood of their self-selection to enter this particular life path? Said another way, were such group differences between dancers and non-dancers due to differences in their education, per se, or instead to differences in genetic predispositions that caused one group (the dancers) to choose to undertake the arts?
Moving beyond the fact that we observed group differences between dancers and non-dancers on select higher cognitive tasks (Years 1-2), in Year 3 we sought to gain new insight into why this finding might be so. Answering this "why" question was not only a scientific imperative—the logical next-step in achieving the most complete answer to the questions posed in our Dana research program—but it was an educational policy imperative. Only by unraveling the factors that contributed to our group differences can we provide compelling evidence to support educational policy in the United States. It is well known that cuts in school budgets often lead first to cuts in school's arts curriculum (over, say, cuts in the math curriculum). By sorting out whether the higher cognitive performance of dancers in our study was due to educational versus biological factors, we can contribute new evidenced-based knowledge to United States educational policy makers on which they may base decisions about whether to cut arts education from young children's curricula during the developmentally crucial elementary school years.
Recently, Bachner-Melman, Dinal, Zohar, Constantini, Lerer, Hoch, et al., (2005) found that dancers have a particular polymorphism on two of their genes. In addition, consortium member Dr. Michael Posner and collaborators have found evidence of genetic influences on performance on attentional tasks (e.g., Posner, Rothbart, & Sheese, 2007). To study whether there might be possible genetic influences underlying any performance differences during higher cognitive tasks in persons highly educated in the arts versus those not educated in the arts—as well as the likelihood of pursuing an arts education—buccal (cheek) swabs were collected from all participants, both while performing a battery of behavioral cognitive tasks and while simultaneously undergoing fNIRS brain imaging.
Seven candidate genes were selected for polymorphism analyses after extensive review of the literature and after important consultation with scholars Drs. Dunbar and Posner. Our particular choice of these seven candidate genes was established on the basis of specific linkages of previously identified genes with specific behavioral profiles. In one such study concerning dance, Bachner-Melman, et al. (2005) found that trained creative dancers had polymorphisms on their serotonin transporter gene SLC6a4 and vasopressin receptor gene AVPR1a—interestingly, polymorphisms not found in athletes and non-dancers.
In such genetics studies concerning attention/higher cognition, consortium scholar Dr. Michael Posner and colleagues have identified polymorphisms in several dopaminergic genes associated with attention and higher cognitive functioning: DAT1, DRD4, MAOA, and COMT. The DAT1 gene has been shown to be related to executive cognitive function and performance on a conflict task (Rueda, Rothbart, McCandliss, Saccomanno, & Posner, 2005). DRD4 and MAOA genes have been shown to be associated with performance on conflict-related tasks (Fan, Fosella, Sommer, Wu, & Posner, 2003). The COMT gene has been associated with performance on attention and working memory-related tasks (Raz, Fan, & Posner, 2006). In genetics studies concerning memory/learning, BDNF (brain-derived neurotrophic factor) has been shown to be associated with episodic memory, LTP (long-term potentiation), and also with learning (Goldberg & Weinberger, 2004).
Participants in the study were adult English monolinguals who had early (before age 7), sustained, and intensively maintained education in the performing arts (dance) versus participants with very little or no performing arts education (non-dancers). Participants were tested behaviorally and all were also tested with the fNIRS brain imaging system (a further subset of participants also underwent MRI/fNIRS co-registration).
Extensive measures were taken to equate our participants across multiple dimensions to ensure that the only major difference between groups was in their arts (dance) expertise. Overall, participants in the study underwent questionnaires for group assignment, followed by the administration of cognitive and perceptual assessment tasks. Two steps were applied to all participants that constituted the basis for expert "dancer" versus novice "non-dancer" group assignment, including an (i) email questionnaire and an (ii) Expert Dance questionnaire or Performing Arts Experience questionnaire. The Performing Arts Experience questionnaire also included a detailed "Personal Pleasure Scale" regarding the performing arts, as well as general information about their propensity to engage in other daily/weekly activities and-or intensive education/training regimes (e.g., house cleaning, shopping activities, sports and exercise education/training regimes, etc.). We collected standardized academic performance measures (SAT scores). Regarding assessment, participants underwent standardized assessments, including measures of non-verbal relational reasoning, language competence, cognitive and attentional processing, and biological motion perception (consisting of whole body dance and walk visual processing).
Selection of those to participate in the dancer, and non-dancer, groups was made on the basis of this information—and following from the Petitto team's rigorous Expert-Novice criteria—as well as in Berens, Kovelman, White, Shalinsky, Gramacy & Petitto, (2007), and in our submitted manuscript for journal submission. Briefly, participants in the "dancers" group had (i) >8 years dance education, (ii) begun education in dance before age 7, (iii) continued dance education/training into adulthood, (iv) extensive professional performance experience, and (v) reported dance as "pleasurable."
Procedures for the "Mind-Brain-Gene" Study
Regarding behavioral assessment of cognitive performance, participants underwent several standardized assessments, including measures of their English language expression and proficiency (language performance assessment), cognitive and attentional processing, and whole body biological motion visual perception processing. Regarding fNIRS brain imaging assessment, participants' brain activity was recorded while they performed the cognitive and attentional processing task and the biological motion perception tasks. Regarding gene assessment, cheek swabs were obtained from all participants immediately prior to the simultaneous behavioral and fNIRS assessments. All swabs were assigned a random, 4-number-4 letter anonymous code, so that no participant could ever be tied to a specific cheek swab. This process also ensured that the genetic study scientists were "blind" to the participants' background during data analyses.
The collected buccal swabs from all dance and non-dance group fNIRS participants were stored in an Isotemp freezer while waiting to be analyzed. Collected buccal swabs from both the Petitto and Dunbar laboratories were then driven to the "Center for Functional Genomics" at SUNY Albany for standard PCR-based amplification and genotyping analyses.
To ensure accuracy and neuroanatomical precision across new fNIRS technology, as compared to existing MRI technology, in Year 3 we completed the collection and analyses of co-registration data between the MRI/anatomical and fNIRS in a subset of our adult participants. This important procedure is required whenever data across two technologies are compared. By doing so, we gain the greatest confidence with regard to recording from the neuroanatomical sites that precisely correspond to our brain regions of interest (ROI), thus permitting the most accurate study of higher cognitive functions and specific brain regions. During Year 3 (and end of Year 2), entirely new participants were rigorously screened, and new adult dancer and non-dancer groups were established. These participants then participated in our cognitive attentional and Biological Motion Perception behavioral tasks, while undergoing fNIRS brain imaging. In Year 3 we completed fNIRS system imaging of these new participants.
Preliminary Results and Status of Analyses of fNIRS
First, the behavioral data collected from participants while undergoing this new round of fNIRS brain recordings during the Biological Motion Perception tasks showed a similar pattern of results as those collected without simultaneous scanning (off-line). That is, the present behavioral results replicated the behavioral findings observed in the Year 1-Year 2 study described above.
Second, the fNIRS brain imaging data collected during the visual Biological Motion Perception task showed that dancers had greater right than left hemisphere parietal brain activation, while non-dancers showed the reverse pattern (p < .02). In a striking contrast of neural activity and behavior, both groups exhibited similar activation patterns during Biological Motion trials depicting walking, with lateralization differences emerging only on trials depicting dancing.
Third, regarding the genetics data, we have received results for four genes from our target list of seven. Due to the labor-intensive nature of these genotyping analyses, the Center for Functional Genetics (SUNY Albany) is still working on the remaining three genes. Nonetheless, we have now received genotyping results for four of our candidate genes. Most intriguingly, the preliminary results suggest that there are no differences between our dancer and non-dancer groups on COMT, MAOA, and 1 of the DRD4 polymorphisms. (Recall that COMT, MAOA, and DRD4 have been associated with performance on attention and working memory related tasks; Raz, Fan, & Posner, 2006.)
Although exceedingly preliminary, these exciting results suggest support for the hypothesis that the differences between our two groups may be due to their education in the arts, rather than to genetic predispositions. We are currently awaiting the outstanding genotyping data and are in the data interpretation stage of this Mind-Brain-Gene (genotyping) study of dancers versus non-dancers.
The above combined "Mind-Brain-Gene" study of the impact of education in the arts on the mind (as revealed through behavioral measures of cognitive processing), the brain's functional architecture, and genes, may soon have important educational implications. Additional results corresponding to the preliminary results described above have the potential to provide educators, policy makers, and parents with evidence that early and sustained education in the arts may afford young students long-lasting advantages in other core cognitive domains—thereby providing a powerful "translational benefit" from scientists to the greater society.
Year 3 Tangible Products from Dance, fNIRS, and Music Studies
A journal manuscript of the Dance Behavioral study has now been submitted for publication and is under review. A poster of both the Dance Behavioral and the Dance fNIRS studies was presented at the annual Cognitive Neuroscience Society meeting held in New York, NY, May, 2007. Our fNIRS manuscript, in which we offer the discipline a universal analysis method, has been revised and resubmitted. In depth Dance fNIRS analyses are presently in progress. Once data analyses are complete, a journal manuscript of the Dance fNIRS study will be submitted. Over the course of the coming year, we will prepare the genotyping data both for presentation at a major scientific and an educational conference as well as for journal manuscript submission. Clearly, the completion of this important Dana research activity awaits the return of the final genotyping data results from the Center for Functional Genomics scientists at SUNY Albany.
Following from this Dana Foundation genotyping work, Kevin Dunbar (Dana recipient) and Laura-Ann Petitto are writing a manuscript for journal submission in which they lay bare this new method, its theoretical power, and its implications for the study of higher cognition, as well as the arts and education. Final closure on all work (involving, for example, revisions and publication of submitted manuscripts, final analyses of genotyping results, publication of Dance and fNIRS results, presentation and publication of genotyping results, and combined presentation/publication of Dance-fNIRS-Genotyping results) will occur over the next year.
(see Part 2 below)
2007 Dance
Berens, M.S., Kovelman, I., White, K.S., Shalinsky, M.H., Gramacy, R. & Petitto, L.A., (May 5-8, 2007). "Cognitive benefits and neural processing following early and continued arts education in Dance." Abstracts for the Cognitive Neuroscience Society. New York, NY.
Berens, M.S., Kovelman, I., Grammacy, R.S., & Petitto, L.A. (under review). Evaluation of the benefits dance expertise has on higher cognition.
2007 fNIRS Brain Imaging (Advancement in brain imaging Methods)
Shalinsky, M., Kovelman, I., and Petitto, L.A. (Revise and Resubmit, 2007). Analysis method to shed new light on the brain's cognitive functions using fNIRS.
2007-2008 Genes (Advancement in genetic Theory and Methods)
Dunbar, K. and Petitto, L. (Manuscript in preparation). Molecular Epigenesis: A new microarray-based method for determining the interactions of genes and environment.
2007 Music
Berens, M.S., Kovelman, I., & Petitto, L.A. (May 24-27, 2007). "Benefits of Childhood Music Education on New Language Learning." Association for Psychological Science conference, Washington, DC.
Berens, M.S., Kovelman, I., Shah, A., & Petitto, L.A. (forthcoming). Does early childhood exposure to Music provide cognitive enhancement?
Study Hypothesis
In this Dana Consortium study involving music, our goal was to understand whether extensive childhood musical education impacts higher cognitive attentional abilities and second language learning in adulthood. Because learning another language involves the ability to attend to one language, inhibit the other language, and rapidly switch between them, and because musicians have been shown to have enhanced selective attention on particular higher cognitive tasks (e.g., Crawley, Acker-Mills, Pastore, and Weil, 2002; Schellenberg, 2005), this study tested the following hypothesis: Monolingual expert musicians would learn their new/second language better than non-musicians (equated on all other factors).
Study Participants
Participants in the study were monolingual English-speaking students enrolled in Introductory Italian or Spanish classes (Spanish 001 or Italian 001). Participants were tested twice, once at the beginning of the academic term (T1) and once at the end of the academic term (T2).
Study Procedures
Extensive measures were taken to equate our participants across multiple dimensions to ensure that the only major difference between groups was in their arts (music) expertise. Overall, participants in the study underwent questionnaires for group assignment, followed by the administration of cognitive/linguistic and attentional assessment tasks. Two steps were applied to all participants that constituted the basis for "music" versus novice "non-music" group assignment, including an (i) e-mail questionnaire, and an (ii) Expert Music questionnaire or Performing Arts Experience questionnaire. We collected standardized academic performance measures (SAT scores). Regarding assessment, participants underwent standardized assessments, including measures of language competence, cognitive and attentional processing. Based on responses on these questionnaires about their music education, participants were divided into musician and non-musician groups, with those who received early extensive and continued music education classified as musicians; see summarized details in Dance studies above.
For assessment, participants were measured on their English competence/expressive proficiency (language performance assessment), new language competence/expressive proficiency, cognitive attentional processing, end-of-term self-evaluation, and class final grade. Native Italian, Spanish, and English speakers conducted data transcription, coding, and reliability checks/measures, and all analyses.
Analyses of these data found no differences in general academic performance measures—the SAT, Final Class Grade, and Self-Evaluation. This is what we had predicted. We observed that there were also no differences between groups on the cognitive attentional assessments.
Importantly, our findings demonstrate that musicians exhibited significantly increased language competence and proficiency in their new (second) language as compared to non-musicians, even after only one term of language instruction (p < .05).
The Music study results suggest that there may be an enduring cognitive advantage afforded by early and extensive music education on adult learning of a new language in an instructional setting. Specifically, musicians showed greater improvement in expressive fluency and competence in their new language than non-musicians.
Tangible Products of Music Study Years 1, 2, 3
A manuscript of the Music study is in progress. A poster of the Music study was presented at the annual Association for Psychological Science conference, held in Washington DC, May, 2007. The Petitto Laboratory recently moved to the University of Toronto, where they will continue research in the Performing Arts and where additional collaborative opportunities exist (e.g., Dr. Glenn Schellenberg's aboratory).
Bachner-Melman, R., Dina, C., Zohar, A.H., Constantini, N., Lerer, E., Hoch, S. et al. (2005). AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLOS Genetics, 1(3), 394-403.
Bever, T.G. & Chiarello, R.J. (1974). Cerebral dominance in musicians and nonmusicians. Science, 185(4150), 537-539.
Fan, J., Fosella, J. Sommer, T., Wu, Y., & Posner, M.I. (2003). Mapping the genetic variation of executive attention onto brain activity. Proceedings of the National Academy of Sciences, 100(12), 7406-7411.
Crawley, E.J., Acker-Mills, B.E., Pastore, R.E. & Weil, S. (2002). Change detection in multi-voice music: The role of musical structure, musical training, and task demands. Journal of Experimental Psychology: Human Perception and Performance, 28(2), 367-378.
Goldberg, T.E. & Weinberger, D.R. (2004) Genes and the parsing of cognitive processes. TRENDS in Cognitive Sciences, 8(7), 325-335.
Keller, P.E. (2001). Attention resource allocation in musical ensemble performance. Psychology of Music, 29(1), 20-38.
Large, E. W. & Jones, M. R. (1999). The dynamics of attending: How people track time-varying events. Psychological Review, 106 (1), 119-159.
Posner, M.I., Rothbart, M.K., & Sheese, B.E. (2007). Attention genes. Developmental Science, 10(1), 24-29.
Raz, A., Fan, J., & Posner, M.I. (2006). Neuroimaging and genetic associations of genetic and hypnotic processes. Journal of Physiology, 99, 483-491.
Rueda, M.R., Rothbart, M.K., McCandliss, B.D., Saccomanno, L. & Posner, M.I., (2005). Training, maturation, and genetic influences on the development of executive attention. Proceedings of the National Academy of Sciences, 102(41), 14931-14936.
Schellenberg, E.G. (2005). Music and cognitive abilities. Current Directions in Psychological Science,14(6), 317-320.
back to top
Get the latest neuroscience news delivered to your inbox.


text:
Semi-Annual Subscription Service
To continue reading this entire article you must be a paid subscriber.
Subscribe to Aviation Consumer
Aviation Consumer is the independent online source for impartial and uncompromising evaluations of aircraft, avionics, accessories, equipment and more.
Already subscribe but haven't registered for all the benefits of the website? Click here.
Subscriber Log In
Forgot your password? Click Here.


text:
Controlling claim costs
When an injured worker returns to their job after a workplace injury, everybody wins. Providing care and assistance in returning injured workers back to the workplace reduces costs and lowers premiums for employers and helps businesses succeed. You can help control costs by keeping workplaces safe and getting injured workers back to work as safely and quickly as possible.
Getting injured workers back to a productive life, at home and at work, requires a partnership between the injured worker, the employer, health-care providers, BWC and the MCO.
- Returning to work - programs and services to help eligible injured workers safely maintain their employment or return to work
Many times, the injured worker returns to their former job. When that's not possible - at least immediately - there are programs, services and other claim management strategies that can help control the costs of a claim such as:
- Vocational rehabilitation - Voluntary programs and services tailored to the injured worker and their work environment.
- Transitional work - Program that focuses on returning the injured worker with physical restrictions back to their original job.
- Salary continuation - Voluntary program whereby the employer continues to pay the injured employee full salary and benefits during the period an injured worker is off work.
- Claim Settlement - Settlement of a claim forever resolves all past, present or future medical and compensation liabilities for an employer.
- Subrogation - Process by which BWC collects costs on behalf of injured workers when a third party causes a workers' compensation injury.
- Handicap reimbursement - BWC encourages employers to hire and retain an employee with a handicapped condition.
- Non-at-fault motor vehicle accident claims - The costs of a claim from the result of a non-at-fault motor vehicle accident involving a third party may be excluded from the employer's experience.
- Recreational waiver - An injury or disability incurred during voluntary participation in an employer sponsored recreation or fitness activity is not compensable if the injured worker signed a waiver.
- ${title}${badge}


text:
Woody Woodriffe
I am a sports anchor/reporter for Fox 2 News, and my reports appear on all of the station's newscasts and sports specials.
I came to Fox 2 from WFOR in Miami, where I was responsible for everything under that hot sun. This includes anchoring broadcasts, as well as all of the technical responsibilities of photographer and editor.
I graduated from the University of Miami with a bachelor's degree in communications, specifically in television production.
Follow me on Twitter @Fox2Woody


text:
Welcome To Brothers Windows
About Us
In 1991, Brothers began in Knoxville, Tennessee as a family owned and operated business. Brothers Windows was founded on the core values of customer service, honesty and integrity and by upholding those values we have become the area's residential window cleaning authority. We continue to expand our expertise, knowledge and leadership by frequently adding additional services to meet our customers' growing needs.
Currently in our 22nd year, we continue the tradition of delivering unrivaled professionalism, quality workmanship with competitive, honest pricing that guarantees the highest level of customer satisfaction. We take pride in our business by providing our customers the assurance that all work is 100% guaranteed and will be completed by our well-qualified, professionally-trained Brothers personnel.
All employees are trained to perform their job safely and efficiently, while ensuring the utmost care for our customers' personal property. This training includes OSHA and International Window Cleaning Association (IWCA) safety guidelines. In addition, we are an active member of the Better Business Bureau and are comprehensively insured, bonded and fully licensed.
Remember, at Brothers, we are always "Creating a Better View."
The highest compliment we can receive is a referral to a friend, relative or business associate.


text:
Changing lifestyle is one of the major factors driving the ready meals market. Manufacturers are making it much more convenient for consumers to prepare homemade style foods with the use of fresh and local ingredients. Ready meals are completely pre-cooked meals readily available at retail outlets that are just need to be heated for consuming. Ready meals market is gaining popularity worldwide as it is most convenient and time saving method to have healthy food.
To Read The Complete Report with TOC: http://www.marketresearchreports.biz/analysis/144852
Market Segmentation
Based on type:
- Chilled Ready Meals
- Dried Ready Meals
- Canned Ready Meals
- Frozen Ready Meals
This research report analyzes this market depending on different market segments and major geographies. It is the complete study of analysis of current market trends, industry growth drivers, and market projections. Report also includes analysis of technological improvements in ready meals market, Porter's five force model analysis, and company profiles of top industry players. Report also includes review of micro and macro factors essential for existing market players and new entrants along with detailed value chain analysis. The major geographies analyzed under this market research study are North America, Asia-Pacific, Europe and Rest of the World.
For All Latest Reports Kindly Visit: http://www.marketresearchreports.biz/latest
Some of the major players in this industry are Bakkavor Foods Ltd., Birds Eye Ltd., Findus Group Ltd., Greencore Group PLC, HJ Heinz Company Ltd., Kerry Foods Ltd., Northern Foods Ltd., Premier Foods Group Ltd., and others.
For All Reports Kindly Visit: http://www.marketresearchreports.biz/
Reasons for Buying this Report
- This research report provides forward looking perspective on different factors responsible for driving and restraining market growth
- It provides pin-point analysis of changing competition dynamics, major competitors and their market strategies
- It provides technological growth map over time and explains its impact on market
- This report provides information on innovative product development and market forecast
- Report helps you make informed business decisions by making in-depth analysis of market


text:
>GLSEN is proud to honor Black History Month by celebrating the contributions of the African American community to the LGBT and safe schools movements. Throughout February we will be recognizing the African American heroes who have made significant contributions to the LGBT and safe schools movements. Click here for more information, and keep reading all month long for new additions!
We want to know who your heroes are! If you know an African American person who has contributed to the LGBT and safe schools movement, post about them on the Gay-Straight Alliances Facebook page. You can also tweet your heroes to @DayofSilence using the #GLSENBHM hash tag!


text:
OK, lets just say the cat is very curious and is about to die. There are a few of us that have unusual names on this board. Some of the names are easy to guess and others are not. So lets share the source of our names. There has to be a story behind the name ÂwishthecuttlefishÂ.
Magnet-man is from when I sold neodymium magnets on eBay.
[This message has been edited by magnet-man (edited November 17, 2004).]


text:
In September of last year, graphic artist Eric Testroete and his girlfriend spent nine days as tourists in North Korea. They went back in February for Kim Jong Il's birthday.
Testroete said he was always fascinated by the thought of going into such a restricted country and booked a trip through a travel agency.
Even though he was well-aware of the extent of government control and poverty, many images still shocked him.
Testroete shared exclusive images from his visit and described what was happening in his own words.


text:
Ryan O'Reilly's days as an Av look to be over
They probably have for at least a couple weeks now.
There is absolutely no negotiating going on anymore between Ryan O'Reilly and the Avalanche. While the Avs were optimistic right after the lockout ended that they could sign O'Reilly and my sources said he would not be traded, things have changed and it appears a virtual certainty O'Reilly will be traded now. The sides became entrenched in their positions, things got a little personal and now there appears no turning back. The only questions remaining are to which team and for which players/draft picks in return.
Darren Dreger of TSN reported tonight the Avs are asking for a "roster player and a top prospect." That sounds about right. The Avs will not confirm that's what they are asking for. They won't confirm much of anything right now. They have gone into bunker mentality mode on the Factor.
There is a lot more to this story, but until O'Reilly is traded, I'm kind of bound by an agreement not to report anything until then. Sorry. Really, I'm amazed this all happened. A 22-year-old heart-and-soul, two-way center, an absolute rink rat who loved Denver and loved the Avalanche wound up being the final unsigned big-name restricted free agent in the NHL. Really, it's unbelievable.
There are so many questions left to be answered/resolved with this story. Not to get all negative – because I know how some get all sensitive to that – but it really must be asked: do the Avs have a major problem with the way they do business with their players now? Look at all the good players who – even after giving a lot to this team on and off the ice – things end really badly and they are either traded or released, often to disastrous results.
I give you, among others, Craig Anderson. I'm not going to re-litegate the whole thing here, but there was a guy who had a great year for the Avs, got what he felt was a lowball offer to re-sign, the Avs made no attempt to negotiate off their only offer, things got a little personal and Anderson was dealt away for Brian Elliott.
Anderson took the Senators to the playoffs last year, his first full one in Ottawa. He would easily win the Vezina Trophy right now if the voting were held today. He had a 42-save shutout tonight.
Many GMs who made that trade in other organizations probably would have been fired over that trade. Oh yeah, the Avs cut Elliott loose too and he won a Jennings Trophy last year.
The larger point is: why do so many of these contract problems with good players always keep happening? Ian Laperriere was shocked at how he was treated by this team at the end. He got an insulting one-year offer, with a pay cut, to stay. He couldn't even get his phone calls returned by the organization when he didn't take the offer but wanted to keep negotiating. What kind of management is that? You can't even return the call of a guy who poured out his heart and soul to this team and did countless acts of goodwill for the community? Disgraceful. I get mad just thinking about it. Lappy found a Flyers team happy to take him off the Avs' hands, giving him a three-year, $3.5 million contract, and he played great for a perennial Flyers playoff team until seeing his career end after taking a slap shot to the face.
Tomas Fleischmann – played great for the Avs after they TRADED to get him. They made another lowball, take-it-or leave it offer to keep him. He was shocked, because he liked it here too and wanted to stay and his teammates really liked him too. But he was just let go he's put up about a point a game for the Panthers since and helped them to the playoffs last year. The Avs thought his health (pulmonary embolism) would prevent him from being a reliable player. He plays every night for Florida.
Peter Mueller? Playing well for Florida, after the Avs just tsk-tsked him and let him go. There have been other similar stories. Now, O'Reilly appears to be joining the list.
Wow, the Avs had better win this trade for a change, because if you think it's bad now, just wait if Greg Sherman, Pierre Lacroix and Co. come up empty on another deal. The whole hockey world will be watching. By the way, I've talked to about half a dozen general managers about this and none of them can believe the Avs would even consider trading Ryan O'Reilly, especially over such a relatively minor difference in money – at least on a short-team deal. I've talked to even more players around the league about it. ALL of them just rave about the kid, saying he was one of the toughest guys in the league to play against.
But, hey, it's their business. They can run it the way they want. All I know is this is the last-place team in the Western Conference and an organization that has been a lottery team in two of the last three. It would seem, at least on paper, that the way they do business hasn't produced very good results.
But maybe I'm just being too critical.


text:
ob Summary:
Responsibilities include diagnosing, repair and maintenance of on- site heavy construction equipment.
Job Requirements:
* Some travel is required
* Must possess a clean State of Florida driver's license
The above statements are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not to be construed as an exhaustive list of all responsibilities, duties, and skills required of personnel so classified. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.
To apply for this job please visit the following URL: https://workforcenow.adp.com/mascsr/default/mdf/recruitment/recruitment.html?cid=5846b24b-45ff-45da-ba77-791ea52c1dc0&ccId=19000101_000001&jobId=294845&lang=en_US&source=CC4 →


text:
A spring day on Boka Bay
Leave a Reply.
Charles (Karlo) Baker-Clark
I am a university professor with interests in the relationship of food and culture. I am also a Fulbright Scholar and will deploy to Montenegro in September, 2014 where I will collaborate in teaching and learning about food and culture as well as food tourism. This blog is dedicated to sharing my experiences in Montenegro with you. It is also dedicated to my son Chad who mixes artistry and savvy in teaching people how to bake bread and make pizza.
This site, Zdravo (Hello) From Montenegro, is not an official Fulbright site. The views expressed on this site are entirely those of its author, Charles A. Baker-Clark, and do not represent the views of the Fulbright Program, the U.S. State Department or any of its partner organizations.


text:
Are You a Job Seeker? Register | Login
© 2019 ShikshaCentre. All rights reserved.
Teacher Jobs in Bangalore – Math, Chemistry, Biology, Science, Physics, English Professor, Faculty, Principal, Lecturer, School, College, University – Bangalore, Hyderabad, Chennai | India
You are about to see a demo of careercubicle.com. Please note that information contained here is confidential and should not be shared with others for commercial purpose.
Agree by clicking Close


text:
« Back to Ta3mini.com - Restaurants in Lebanon. Find Reviews and Phone Number of Restaurants in Beirut, Saida, Tripoli, Jounieh...
Burger Bites – Monot
Classic and Original Mini-Burgers
Review by Souad
As its name implies, Burger Bites is a specialized restaurant that only serves mini-burgers. The restaurant has a great location in the Monot neighborhood. The place is simple and cosy.
You will find a variety of classic and original burgers such as "Classic Cheese", "I'm So Blue", "Jalapeno"… The idea of serving mini-burgers is very convenient because you can adjust the number of bites you order to your hunger. And at the same time, you can taste many varieties during the same dinner. The size of the bite is big enough to make you really taste it and small enough to let you try another one. Personally, three bites were enough for me, I loved the presentation, my favorite "bite" was the Veggie however I found the potato chips too oily and some of the bites were too heavy for my taste.
The service at Burger Bites is friendly and prices are affordable. When ordering, don't forget to ask for the off-menu items and later on for your free soda refill.Write a Review
Classic and original mini burgers
Suitable for vegetarians. Serves alcohol.
Good to know
Smoke-free restaurant. Recommended for friends.
St. Joseph University, Monot Street, Ashrafieh
Call them
Phone Number: 01 215 424 or 71 758 658
Website: http://www.burgerbiteslb.com/
Opening hours
Mon - Sun: 11:30 am - Late
Get there
St. Joseph University, Monot Street, Ashrafieh
See Also
BRGR Co. - Ashrafieh(5 votes)
Premium quality burger restaurant
Classic Burger Joint(63 votes)
Burgers in a Non Fast Food Way
Tomatomatic Pizza - Ashrafieh(5 votes)
Pizzeria in Monot with regular and signature pizzas
Bob's Easy Diner(3 votes)
Good Value for Money Diner
Marky's - Horsh Tabet(7 votes)
Philly Joint Serving Awesome Food
Street Burger - Mar Mikhael(1 votes)
Classic and Innovative Burgers


text:
Shop Our Store
More Ways To Shop
Fuel Line, Front to Rear, Stainless Steel, 3/8 in., Chevy, GMC, Set of 3
Estimated Ship Date: Loading... (if ordered today) Would you rather pick it up? Select Location
The part RSD-TGL8187S has an additional shipping charge of $20.00 per item due to its large size and/or weight.
View Similar Products
Brand: Right Stuff Detailing
Manufacturer's Part Number: TGL8187S
Part Type: Fuel Lines, Tank to Pump Lines
Product Line: Right Stuff Detailing Front to Rear Fuel Lines
Summit Racing Part Number:
Fuel Line Material: Stainless steel
Fuel Line Finish: Natural
Fuel Line Diameter: 3/8 in.
Quantity: Sold as a set of 3.
Notes: Dual tank cross overrt
In-Store Pickup: Choose In-store pick-up (OH, NV, GA, TX) on our web site.
Right Stuff Detailing offers you the best-fitting, most exact reproduction fuel lines on the market. They utilize state-of-the-art CNC benders and automated end-forming machines that double-flare lines with remarkable consistency. Right Stuff Detailing front to rear fuel lines are available in OEM steel or stainless steel, as well as various diameters and configurations for direct fit replacement on hundreds of vehicles.
What type of question would you like to submit?
I have a Customer Service question
(order, shipping, returns, etc.).
I would like to ask other customers
a question about this Product.
There are no questions for this product.
Some parts are not legal for use in California or other states with similar laws / regulationsBack To Results
We do not sell email addresses or other private information.
Privacy Policy
Low Price Guarantee
We're so confident in our low prices, we offer a Beat-a-Price Guarantee: We'll beat our competitors' advertised prices on any identical, in-stock product (proof of advertised price required)!Beat-a-Price Guarantee Details


text:
Mr Spin Casino Sign in for £5 Bonus Free Spins & Alternatives!
|Site Name:
|Mr Spin Casino Sign in - £5 No Deposit Free Bonus Deal!
|Intouch Games Ltd
|100% up to £€100
|Bonus Code:
|None needed - just use links on this page for bonus
£5 FREE – Enjoy Mr Spin Casino Full HD Pay By Phone Bill Slots On Your Mobile: Get Exciting 50 Free Spins
Join in all the £5 free casino and slots fun, with Mr Spins fun games with mobilecasinofun.com
Mr Spin Casino allows players to play fun-filled and exciting mobile slots casino games for free without having to deposit any money of their own, by giving all new members a free 50 slots spins bonus. This means that UK players can try out exclusive slots games and familiarise with the gameplay and site navigation at Mr Spin Casino & Spin Genie for free. Better still is that if you clear the wagering requirements and have verified your account, you can also keep what you win!
The Mr Spin Casino Review by Thor Thunderstruck for mobilecasinofun.com
Curious wannabe online slots players can even play games for free in demo mode without signing up, but need to beware: This fun-filled and cheerful site will have them hooked in no time, and once they experience the fabulous Return to Player that these games present, signing up for their membership account is just a few clicks away.
Anyone who desires to win real cash prizes or access jackpot features must first register for a Mr Spin Casino deal, so sign into a new account in order to receive the 50 free spins equivalent to £5 no deposit casino bonus. The registration process is very simple – just download the game and click 'register' from its main menu, verify your account, receive free casino bonus – no deposit required – and start spinning to win real money!
Claim Your Free Spins & Enjoy Other Amazing UK Casino Promotional Deals
See More Mr Spins Winning Info After the Bonus Table Below
Ready to Enjoy a Top Ranked UK Mobile Casino with Instant Payment Options?
Play Real Money Mr Spin Slots Games Using Casino Phone Bill From £3 – Sign Up Now
Share Mr Spin Casino Signin Bonus With Friends, Earn 50 Free Spins + Mr Spin Login and get 50 Free Spins
One of the most attractive features of this fabulous phone casino, is that it grants players free spins on every new game. Even existing players won't have to deposit and money to try these games out. In addition, any money won from the free spins can be cashed out once the player has cleared the wagering requirements. Wait a minute…Mr Spin Casino & Spin Genie have No Wagering Requirements…Therefore, players can keep what they win from the bonuses and free Mr Spins Slots & Table Games, as soon as they play through the bonus. It's really that easy!
As far as gaming options are concerned, there might only be a small – but curated – selection of mobile slots games on offer, but players won't be disappointed!
- Hang out with canine coppers in Dog Detectives
- Roll in for the circus themed Jackpot Big Top Online Slot
- Action packed Bonnie and Clyde slots
- Fun and quirky Polar Slots
- Explore the magic of the enchanted forest in Pixies & Crystals
Mobile phone depositing is a feature that allows players to use their mobile phones as credit cards. This means that any payments made via phone casino billing are deducted from the available phone credit. Well, Mr Spin Casino supports phone casino credit billing, so winning on the move is even easier!
There are fascinating casino sites pay by phone bill features such as reload bonuses, free spins and weekly promotions with Mr Spin Login. UK players should know that the minimum deposit is £3 while using the pay by phone bill feature, making this site one of the most affordable real money online gambling destinations in the UK.
To get the 50 free spins welcome bonus, one must sign up at Mr Spin. After making their first deposit, the player is granted 30 more free spins. There is also a 100% match bonus on the first deposit capped at £100. Refer a friend and get an extra 50 free spins, as well as regular free spins bonus deals to enjoy new games releases. Now you know how this casino got its name!
Find Great Games, New Mobile Slots And Real Cash Casino Tournaments Right Here!
Mr Spin Casino is powered by Intouch Games. This software provider has a good reputation for developing some of the UK's most popular mobile casino games. Each of these games comprises a progressive jackpot feature, as well as inbuilt mini games to really boost a player's winnings!
Also Consider Playing this game below with £5 Free from Coinfalls.com
Read Full Coinfalls.com Review HERE


text:
If SXSW has produced any breakout startups this year, it's Highlight.
Highlight is a subtle way to stalk people you've never met but share common interests with. It shows who has been nearby throughout the day and pulls in Facebook data on them, including where the person works and their pictures. It shows the person's location in relation to yours on a Google map. In-app messages can be sent to nearby people too.
Highlight has received mixed reviews. What's most controversial is that it only pulls information on strangers. You're not swapping personal information with trusted friends. There's no option to check-in, although you can pause Highlight for any length of time.
Last week, in preparation for SXSW, I downloaded the app. After an hour I found my battery life had been significantly drained. I also didn't like the feeling of being watched, so I deleted Highlight from my iPhone. On my flight to SXSW, I had a change of heart. I looked around the terminal and realized most of the passengers were heading to the conference. Some were familiar faces but I had trouble placing names. So, I downloaded Highlight again. I pulled it open and tried to be stealth in my stalking. The director of a startup I've covered was close by. I glanced up sheepishly trying not to get caught. Then I spotted him.
A few feet away was a TechStars NY team I had met once before.
In the past three days, Highlight has found 116 other users in my vicinity, including Rick Webb and Dave Morin, two people I would like to meet.
People have been respectful on Highlight too. Maybe I'm just not that cool, but no Highlight stranger has tapped me on the shoulder. I've only received one message on it and the person merely wrote, "Hi Alyson! How's it going?"
I've kept myself logged out of Highlight for most of SXSW. The battery draining issue is a big problem. SXSW is also too overwhelming to be a good use case for Highlight. Many of the 15,000 attendees have the app, and when you're sitting on panels or attending parties, you'll get pinged an annoying amount of times. Other Highlight users I've spoken with at SXSW have had similar experiences. One startup executive told me he saw a product manager from Square sitting nearby but felt too strange to make a move. Later, he noticed an investor was close and it reminded him to reach out.
Right now, having Highlight is semi-beneficial and cool. Tech influencers are the only people on it and many of them are people I'd actually like to meet. If Highlight goes mainstream however, I won't get excited that Susie from The Flower Shop is three feet away. Highlight could also be used as a new form of dating. If you're in a bar and see someone attractive, you can learn a little bit about them before approaching. If you see they're already in a Facebook relationship, Highlight could save your breath.
I won't be using Highlight much, but I also won't be deleting it again.


text:
|System: PS3, Xbox 360
|Dev: WayForward Technologies
|Pub: Majesco Entertainment
|Release: September 6, 2011
|Players: 1
|Screen Resolution: 480p-1080p
|Violence, Blood and Gore, Suggestive Themes, Mild Language
There are 15 levels of brutal non-stop action, and players will have a few reasons to want to go back through the game after the initial, second, and maybe even third playthrough. Aside from trying to pad their achievements/trophies collections, players will also search for bright red skulls in each level. Collecting five of these—many of which are very well-hidden—will allow players to choose to increase Rayne's health or the number of bullets she can carry. It might not exactly be the greatest reason to go back through the game, but when you can have this much fun mindlessly hacking at vampires and other nasty creatures of the night, why wouldn't you want to?
Visually striking, BloodRayne: Betrayal breathes new life into Rayne and the world she lives in. Reimagining Rayne's world with an anime/manga allows Rayne and her enemies to feel more alive. The backgrounds are sharp, crisp, and rival other side-scrolling games currently on the market. Rayne, in my opinion, has not been represented this well in a very long time; I'd say it's even refreshing to see this spin on her character. The solid mix of classical music and explosive guitar riffs set the pace for the game, enhancing the kinetic charge of the fast-paced combat.
BloodRayne: Betrayal may not be all that revolutionary. In fact, it's probably safe to assume the developers wanted to play it safe with this title. I can't fault them for their logic, either. Betrayal succeeds on so many levels that you won't complain after seeing something that's already been done before. It might be familiar, but it's never obnoxiously so.
This game allows you to mindlessly kick the crap out of things while playing as a badass vampire chick. If that sounds like something you'd like, then BloodRayne: Betrayal will not disappoint. And if this doesn't sound like a great way to spend a fall afternoon, then you may be one of the undead yourself.
Matt Walker
CCC Site Director
Game Features:


text:
Ralitza Gueorguieva, PhD
Senior Research Scientist in Biostatistics; Director of Biostatistics in Psychiatry
Departments & Organizations
School of Public Health: Biostatistics: Statistical Methods in Psychiatry and Related Fields: Longitudinal, Clustered and Other Repeated Measures Data
Center for Biomedical Data Science
Center for the Translational Neuroscience of Alcoholism
Neuroscience Research Training Program (NRTP)
Yale Tobacco Center of Regulatory Science
Dr. Gueorguieva obtained her Ph.D. in Statistics from University of Florida in 1999 and has been a faculty member of the Department of Biostatistics at Yale University School of Public Health since 2000. Her research interests are in methodological development of models for longitudinal data and outcomes of different types, assessment of risk and the application of innovative statistical approaches for clinical trials data. She has developed statistical techniques for simultaneous analysis of repeatedly measured categorical and continuous outcomes, risk assessment screening algorithms, models for joint analysis of longitudinal and survival outcomes, and has applied trajectory-based approaches and recursive partitioning methods to the assessment of treatment effects. Dr. Gueorguieva is collaborating extensively with psychiatric researchers on clinical trials and observational studies in alcoholism, substance abuse, depression and anxiety disorders, women's behavioral health, schizophrenia, bipolar disorder, obsessive-compulsive disorder and posttraumatic stress disorder. She advocates the use of modern statistical methods such as mixed and mixture models, tree-based methods and nonparametric alternatives to address the complexity of psychiatric data.
Education & Training
|University of Florida (1999)
|University of Florida, Statistics (1996)
|Sofia University (1994)
Honors & Recognition
Certificate of Appreciation for dedicated service and valuable contributions as one of the Top 10 Reviewers for Biological Psychiatry in 2011.Biological Psychiatry (2012)
Certificate of Appreciation for dedicated service and valuable contributions as one of the Top 10 Reviewers for Biological Psychiatry in 2007Biological Psychiatry (2008)
International Biometric Society's Eastern North American Region (ENAR) Student Award (1999)
First place, Student Abstract Competition, Annual Florida Epidemiology Meeting (1998)
R. L. Anderson Student Paper Award, Southern Regional Conference on Statistics (1998)
The Statistics Faculty Award for the Outstanding Senior Graduate Student, Department of Statistics, University of FloridaUniversity of Florida (1998)
Professional Service
National Science Foundation (2009) Reviewer
International Program Committee for the International Biometrics Society Conference (2007 - 2008) Member
Biological Psychiatry (2007 - Present) Editorial Board Member
Journal of the Royal Statistical Society, Series A (2007 - 2010) Editorial Board Member
Biometrics Section of the American Statistical Association (2007 - 2008) Publication Officer
The Netherlands Organisation of Health Research and Development, Prevention Programme (2006) Reviewer
Liaison Committee for combined BA/BS-MPH degree program (2005 - 2006) Member
Admissions Committee for MPH program (2005 - 2006) Member
NIMH (2004 - Present) Ad-hoc Member, Special Emphasis Panels
Teaching Biostatistics to Students Sofia, Bulgaria (2013 - 2013)
Dr. Gueorguieva taught a course in biostatistics for participants in the M.Sc. program in Probability Theory and Mathematical Statistics and provided mentorship to students at Sofia University.
Family Association Study of Neurocognitive Impairment in Patients with Bipolar Disorder Sofia, Bulgaria (2009 - 2009)
Dr. Gueorguieva provided statistical consultations to the project team.
UNICEF Early Child Development Project Bulgaria (2008 - 2008)
Dr. Gueorguieva provided guidance on statistical analyses to the national team of the Child Nutrition, Rearing and Parenting Practices study in Bulgaria.
Research and Teaching Sofia, Bulgaria (2008)
As an affiliated member of the Section of Probability Theory and Mathematical Statistics, Dr. Gueorguieva has taught training courses, participated in seminars and research projects with Bulgarian scientists.


text:
WASHINGTON � Up against a deadline, Congress passed and sent a waiting President Obama legislation late Wednesday night to avoid a threatened national default and end the 16-day partial government shutdown,...
WASHINGTON � Up against a deadline, Congress passed and sent a waiting President Obama legislation late Wednesday night to avoid a threatened national default and end the 16-day partial government shutdown, the culmination of an epic political drama that placed the U.S. economy at risk.
The Senate voted first, a bipartisan 81 to 18 at midevening. That cleared the way for a final 285 to 144 vote in the Republican-controlled House two hours later on the legislation, which hewed strictly to the terms Mr. Obama laid down when the twin crises erupted more than three weeks ago.
The legislation would permit the Treasury to borrow normally through Feb. 7 or perhaps a month longer, and fund the government through Jan. 15. More than 2 million federal workers would be paid � those who had remained on the job and those who had been furloughed.
At the White House, Mr. Obama hailed the Senate�s vote and encouraged the House to follow suit. Once the measure reaches his desk, he said, �I will sign it immediately. We�ll begin reopening our government immediately and we can begin to lift this cloud of uncertainty from our businesses and the American people.�
As debate began in the House, Rep. Harold Rogers, R-Ky., said, �After two long weeks, it is time to end this government shutdown. It�s time to take the threat of default off the table. It�s time to restore some sanity to this place.�
The stock market surged higher at the prospect of an end to the crisis that also had threatened to shake confidence in the U.S. economy overseas.
Republicans conceded defeat after a long struggle. "We fought the good fight. We just didn't win," conceded House Speaker John Boehner as lawmakers lined up to vote on a bill that includes nothing for Republicans demanding to eradicate or scale back Mr. Obama's signature health-care overhaul.
"The compromise we reached will provide our economy with the stability it desperately needs," said Senate Majority Leader Harry Reid, declaring that the nation "came to the brink of disaster" before sealing an agreement.
Senate Republican Leader Mitch McConnell, who negotiated the deal with Reid, emphasized that it preserved a round of spending cuts negotiated two years ago with Mr. Obama and Democrats. As a result, he said, "government spending has declined for two years in a row" for the first time since the Korean War. "And we're not going back on this agreement," he added.
Only a temporary truce, the measure set a timeframe of early next winter for the next likely clash between Mr. Obama and the Republicans over spending and borrowing.
But for now, government was lurching back to life. In one example, officials met to discuss plans for gearing back up at the Department of Housing and Urban Development, where 307 employees remained at work during the partial shutdown and more than 8,000 were furloughed.
After weeks of gridlock, the measure had support from the White House, most if not all Democrats in Congress and many Republicans fearful of the economic impact of a default.
Boehner and the rest of the top GOP leadership told their rank and file they would vote for the measure, and there was little or no doubt it would pass both houses and reach the White House in time for Mr. Obama's signature before the administration's 11:59 p.m. Oct. 17 deadline.
That was when Treasury Secretary Jacob Lew said the government would reach the current $16.7-trillion debt limit and could no longer borrow to meet its obligations.
Tea party-aligned lawmakers who triggered the shutdown that began on Oct. 1 said they would vote against the legislation. Significantly, though, Texas Sen. Ted Cruz and others agreed not to use the Senate's cumbersome 18th century rules to slow the bill's progress.
In remarks on the Senate floor, Cruz said the measure was "a terrible deal" and criticized fellow Republicans for lining up behind it.
McConnell made no mention of the polls showing that the shutdown and flirtation with default have sent Republicans' public approval plummeting and have left the party badly split nationally as well as in his home state of Kentucky. He received a prompt reminder, though.
"When the stakes are highest Mitch McConnell can always be counted on to sell out conservatives," said Matt Bevin, who is challenging the party leader from the right in a 2014 election primary.
More broadly, national tea party groups and their allies underscored the internal divide. The Club for Growth urged lawmakers to vote against the congressional measure, and said it would factor in the organization's decision when it decides which candidates to support in midterm elections next year.
"There are no significant changes to Obamacare, nothing on the other major entitlements that are racked with trillions in unfunded liabilities, and no meaningful spending cuts either. If this bill passes, Congress will kick the can down the road, yet again," the group said.
Simplicity at the end, there was next to nothing in the agreement beyond authorization for the Treasury to resume borrowing and funding for the government to reopen.
House and Senate negotiators are to meet this fall to see if progress is possible on a broad deficit-reduction compromise of the type that has proved elusive in the current era of divided government.
Additionally, Health and Human Services Secretary Kathleen Sebelius is to be required to produce a report stating that her agency is capable of verifying the incomes of individuals who apply for federal subsidies under the health care law known as Obamacare.
Mr. Obama had insisted repeatedly he would not pay "ransom" by yielding to Republican demands for significant changes to the health-care overhaul in exchange for funding the government and permitting Treasury the borrowing latitude to pay the nation's bills.
The shutdown began on Oct. 1 after Cruz and his tea party allies in the House demanded the defunding of the health-care law as a trade for providing essential government funding.


text:
220g Straight Seamless Clip-Ins
Price Per Item
- Color
- #1 Jet Black, #1B Soft Black, #1C Mocha Brown, #2 Chocolate Brown, #4 Caramel Brown, #6 Hazelnut Brown, #18 Chestnut Blonde, #60 Golden Ash Blonde, #613 Bleach Blonde
- Weight
- 220g
Get the va-va-voom you desire with our 220 density seamless clip-in hair extensions. Delivering even more body to your tresses, these clip-ins will help you achieve celeb-worthy glam that's anything but ordinary. No matter what kind of transformation you're looking for, our clip-ins will help you achieve your desired look in an instant.
Package Contains (10 Pieces):
1 x 8 inch wefts
1 x 7 inch wefts
2 x 6 inch wefts
2 x 4 inch wefts
4 x 1.5 inch wefts
Total weight: 220 Grams / 7.76 oz


text: Our fast friends over at SRT will once again participate in the annual Targa Newfoundland rally with a hot Viper ACR and a pair of thumping HEMI® powered Challengers. This grueling seven day rally is in its tenth year and covers almost 1400 miles along the majestic Atlantic coastline of Newfoundland, Canada. Even though the competitors battle the clock and other teams, theyre all on the same page racing for a cause by raising funds for the Autism…Read More


text:
On November 14, 2012, the University System of Georgia Board of Regents named Robert G. Boehmer as the fifth president of East Georgia State College (EGSC). The Regents' decision followed a recommendation by USG Chancellor Hank Huckaby and ends the interim status he has held at EGSC since 2011.
Dr. Bob Boehmer, a decorated professor and former administrator at the University of Georgia (UGA), was appointed as Interim President effective January 1, 2012, after the retirement of Dr. John Black.
Dr. Boehmer comes from a legal background, holding a doctor of Jurisprudence (J.D.) from the University of Oregon School of Law. Before entering the teaching field, he was a partner in an Oregon law firm, practicing there for more than ten years.
After entering the teaching field, Dr. Boehmer went to UGA in 1989, where he received numerous teaching awards including Teacher of the Year and MBA Teacher of the Year from the Terry College of Business, the Richard Russell Teaching Award, the Hatten Howard Award, and a selection as a Lilly Teaching Fellow.
In addition to his teaching, Dr. Boehmer has served in a variety of administrative and leadership roles, most recently as the Associate Provost for Academic Planning at UGA. Before assuming that role, he served as UGA's Associate Provost for Institutional Effectiveness. He has also served as UGA's liaison to the Southern Association of Colleges and Schools Commission on College (SACSCOC) and as a trustee and Executive Committee Member of the organization, and has also served as Chair of the Regents Advisory Committee on Effectiveness and Accreditation.
Dr. Boehmer and his wife, Joyce, have two adult daughters, Megan and Beth, who reside in Oregon.


text:
But what about pregnant mothers? Their babies were developing inside them and their mother's weren't being warned. Dr. Olney was able to show in rhesus monkeys that there were brain lesions in their babies when the mother was fed the same level of MSG as is common in the American diet. There was never any warning issued by the FDA to pregnant mothers to avoid MSG. And the final kicker is that humans turn out to absorb MSG at about 5 times the rate of rhesus monkeys and 20 times the rate of rats, the animals being tested in the lab. In fact, humans get higher blood levels of MSG to a given dose than any other know animal, and we are eating levels of MSG on a par of what can be shown to cause damage in lab animals, all while we get higher blood levels in response. And children's brains are about 4 times more sensitive to MSG than adult brains. Do you see a dangerous path emerging?
And how about foods aimed at children who are slightly older than babies? Can you imagine those cute little circular pasta dishes that come in cans and have tiny little pasta balls? Have your children demonstrated enthusiasm for them? Mine did? In fact, that's all they would eat. Harried, rushed, busy parents are so grateful to find a food their children will eat that comes in a quick and easy can. Just open it up, dump it in a bowl and microwave it and you and the spouse can have a nice dinner later when they are in bed. Have you looked at the can label? Look at the fine print on the bottom and see if you can find any of the following terms for MSG. Caseinate, hydrolyzed vegetable protein, yeast extract, flavorings, textured protein hydrolyzed plant protein, autolyzed plant protein, yeast food or nutrient, glutamic acid, vegetable protein extract. Those are all names for MSG. Many of your child's favorite foods will have more than two or three of these names. Manufacturers don't have to put the final chemical in, just the ingredient and what it's made from. Most of those names are 40-60% MSG, but because they are made from the original product, they can be named as that product.
WWW: What will work for me? Go to the web site "Hidden Names for MSG" on Google and print out the list. There are dozens more on the list. Practice looking at them and using that list when you go grocery shopping. I just went on a plane trip and asked for the spicy tomato juice. It's my favorite drink on plane trips. Guess how many names for MSG I found on the label? I'm so mad. It's all hidden, right before your eyes. We're going to talk about Parkinsons, Alzheimer's, ALS and other nasty illnesses next week. For now, let's start with keeping our own exposure down as much as we can. I bet you can find one product with at least 5 names of MSG on it. I did. Took me about 5 minutes. Clue: it's in the soup section.
Reference: Russell Blaylock and "Excitotoxins, the Taste that Kils"


text:
Nestled behind the African Savannah at Taronga Western Plains Zoo in Dubbo, Zoofari Lodge comprises of 15 luxurious African-style lodges.
For the ultimate wild experience stay in one of the all new Animal View lodges. Recently constructed these safari-style lodges feature African-inspired decor with a king size bed, double bath and overlook a paddock in which Giraffe, Zebra and Eland roam. Guests can sit back and relax on their deck as they watch the sunrise and see the animals meander across the savannah.
All accommodation includes private ensuite, coffee and tea making facilities, mini-bar, fridge and shaded veranda with outdoor furniture.
• Animal View Lodges sleep up to four people, with a king split bed and sofa bed.
• Bushland View Lodges sleep up to six people with a queen bed, two singles and a sofa bed.
All bedding, linen and towels are provided.
Zoofari Lodge Guest House
The lodges are located near a stunning Guest House, where guests can relax at the bar with a quiet drink, indulge in the culinary delights prepared by the Zoofari Lodge chef, enjoy a coffee in the lounge area or even take a dip in the saltwater swimming pool.
Guests can also enjoy private viewing of the African Savannah exhibit where animals such as Giraffe, Eland, Zebra and Buffalo roam, or watch the sunrise touch the landscape as it rises above the tree line.
Sleeping securely in your lodge, don't be surprised if you hear the sounds of the Zoo animals as you retire to your accommodation for the evening or wake in the morning.
No entries were found.


text:
Big Bud.
Like a phantom, they sometimes appear. You might be driving along a country highway somewhere and spot one out at work in the field...."hmm, that was an awful BIG white tractor I think I saw." You crane your neck to see if it was what you thought it was. Maybe you loop back for a second look. Occasionally you might run across one in the classifieds, or on the internet, maybe a rare sighting sitting on a dealer's lot.
But whenever you see one in person....you stop....you look....wow.
I'm talking Big Bud used tractors. I've been tracking auction sale data now for almost 24 1/2 years, all over the U.S. and Canada. I know how tough it is to find a Big Bud coming up for sale. Well, here one comes...on an April 4, 2014 consignment auction in Jamestown, ND, a sale by my friends at Orr Auctioneers. The picture above is of the 1980 Big Bud 525/50 with 1,440 hours showing for sale on this auction.
Yep, a bit turned up by the current owner from it's original 525 HP setting. I wanted to learn more about this tractor so I arranged for a video interview with auctioneer Troy Orr. I just posted the Youtube video preview (click on video below). A fun added feature: Troy arranged for a drone video cam fly around of the Big Bud sitting on their auction lot. Drone cam video action comes at the end of the video. We will have video of this Big Bud selling on the April 4th auction...stay tuned for that. How high will it go?? For now, here's the preview video...enjoy:


text:
IBT researchers connect genetic defect, hydrocephalus
(COLLEGE STATION, Texas) — Researchers at the Texas A&M Health Science Center (TAMHSC) Institute of Biosciences and Technology in Houston have made a connection between a genetic defect and congenital hydrocephalus, a finding that may eventually lead to treatments for the neurological disease.
The study is currently available online in Proceedings of the National Academy of Sciences and will be in an upcoming issue of the journal.
"This paper marks a new beginning in understanding and transferring the potential prevention and treatment of congenital hydrocephalus from the laboratory to the patient's bedside," said Jiang Chang, M.D., Ph.D., associate professor in the Center for Translational Cancer Research and study senior author. "The results are preliminary but very promising for imminent therapy of this disease."
The cerebrospinal fluid (CSF) flow tract supplies the brain with essential nutrients and growth factors throughout development and into adulthood. Malformation of the ependymal epithelium, which constructs the CSF tract and propels flow, can result in a brain fluid buildup called hydrocephalus.
Hydrocephalus is a severe neurological disorder that affects about one out of every 500 newborns, according to the National Institute of Neurological Disorders and Stroke. Precise causes are unknown, but genetic factors are believed to play a significant role.
In their study, Dr. Chang and his colleagues found Rnd3, a protein involved in regulating certain molecular mechanisms, plays a part in hydrocephalus. Its deletion in mice led to disease development due to the increased production of ependymal cells.
Further, Rnd3 has a role with the Notch receptor, a protein involved in many biological processes, particularly cell-to-cell signaling communications. The researchers discovered inhibiting Notch activity curtailed formation of hydrocephalus, which could serve as a potential target for therapeutics.
The next step is to develop drugs with Food and Drug Administration approval for clinical trials in animals, Dr. Jiang said.
Contributing to the PNAS study from the TAMHSC-Institute of Biosciences and Technology were Xi Lin, Xiangsheng Yang and Xiaojing Yue, along with Baohui Liu from Wuhan University in China and Lixia Diao and Jing Wang from The University of Texas M.D. Anderson Cancer Center in Houston. Research was supported by the National Institutes of Health.
Interested in this topic? Contact us for more information.


text:
Three Pairs Supersaver Ankle Running Socks Summer Fruits
A supersaver pack of three pairs of running socks. Wacky by name and appearance but certainly not in terms of function and performance, the Wackysox collection is the best of both worlds for players who like to make a statement. WackySox are high performance sports socks made in Great Britain which feature an ultra-high performance padded Coolmax Pro footbed. Coolmax is the original moisture wicking fabric which transfers sweat away from your skin keeping you dry and cool so you can train or play sports harder.
These soft and comfortable ankle sports socks are ideal for running, cycling, netball and fitness with a fully elasticated top. The external toe seam also ensures comfort and help avoid blistering or toe and nail damage, vital for competitors who give their all in both training and competitions. Our Wacky sports socks are ideal for children, sports men and women looking for a breathable sock to wick the sweat away and allowing them to practice or compete for longer in comfort.
Three pairs of ankle running sports socks: turquoise blue, purple and raspberry pink.
Delivery Information
The cut off time / deadline for any next working day order is 14.00 or 2PM on any weekday.
Orders taken after 14.00 on a Thursday will be deemed to be Friday orders and as such will be due to be delivered on the next working day ie the Monday if express delivery is chosen assuming it is not a public holiday OR 3-5 working days after the Friday if standard delivery is selected.
Orders taken on a Friday after 14.00 will be deemed to be Monday orders and express orders will be due to be delivered on a Tuesday provided that the Monday is not a public holiday etc.
We do NOT offer courier delivery on Saturdays, although the Royal Mail offer Saturday deliveries in the usual way on both standard mail and their Tracked 24 and Tracked 48 services but please note that they do not acknowledge weekends as working days.
Different times and/or arrangements may apply for special occasions such as Christmas and if so these arrangements will appear as an information banner on the home page of this site.
We offer FREE GB mainland delivery on orders over £50
The delivery period stated within which you will receive your order is approximate. Goods will be sent to the delivery address confirmed by you in your order. If you are ordering more than one item, your goods may be sent to you in instalments if certain items are out of stock.
If your delivery address is outside of the UK, you may have to pay import duties and taxes, which are levied once a shipment reaches your country. You must meet any additional charges for customs clearance. Please note, customs policies vary widely from country to country. We recommend you contact your local customs office for further information.
Please note international shipments may be subject to cross-border inspections by customs authorities which might cause a delay in the receipt of your goods.
Our delivery rates are as follows:
Standard GB Mainland Royal Mail delivery (3-5 working days ie Mon-Fri) £3.50
- Royal Mail Tracked 48 - £4.00 Please note that despite their choice of title for this service the Royal Mail do not offer this as a guaranteed 48 hours service!!
- Royal Mail Tracked 24 - £4.99 Please note that despite their choice of title for this service the Royal Mail do not offer this as a guaranteed 24 hours / next day service / this is simply a replacement for their old First Class ie a 1-2 day service!!
Expedited GB mainland* delivery (1-2 working days - a tracked and signed for /next working day delivery 14.00 hours cut off time / NOT available for Saturday deliveries) £6.50 (* excludes highlands and islands). Our preferred delivery courier for next day parcels is Parcel Force.
- Eire delivery (4-5 working days) £8.00
- International (outside of the UK) Tracked Royal Mail delivery £8.00
We have a 30 days returns policy, goods can only be returned within 30 days of original purchase.
The returns address is Wacky Limited, Unit 3, Lighting House, Station Road, East Leake, Leicestershre LE12 6LQ
Any returns need to be received by us in unopened packets and fit for immediate re-sale condition, We cannot accept goods back IF they may have been worn for health and hygiene reasons.
Wacky Limited will be happy to exchange for the same item any products that are damaged or faulty or which have been incorrectly shipped.
We do not offer or include free return bags or return labels, so unless we have sent you something which is faulty or which has been incorrectly picked then the cost of return bags and the cost of return postage are the buyer's responsibility.