text:
Illegal Painkiller Overdoses Kill More Than 1,000 Americans
More than 1,000 Americans died in 6 cities between 2005 and 2007 from overdosing on nonpharmaceutical fentanyl (NPF), in the biggest ever epidemic of overdoses involving illegally produced versions of the painkiller. Health officials predict there will be further outbreaks of NPF overdose because the illegal narcotic is easier and cheaper to produce than heroin.
The figures are being reported today by the US Centers for Disease Control and Prevention (CDC), in the 25th July issue of the Morbidity and Mortality Weekly Report (MMWR).
Illicitly manufactured nonpharmaceutical fentanyl (NPF) is 30 to 50 times more potent than heroin. It is a synthetic opioid and classed by the US authorities as a narcotic.
The findings of a CDC and Drug Enforcement Agency (DEA) investigation showed that between 4th April 2005 and 28th March 2007, a total of 1,013 deaths occurred in six US jurisdictions; the largest NPF epidemic to date. This is nearly 10 times higher than an epidemic in the 1980s when 110 people died of fatal overdoses of different fentanyl analogs, said the report.
The largest number of deaths were in metropolitan Chicago (349), Philadelphia (269), and Detroit (230). The other areas were St. Louis, Missouri, and the states of Delaware and New Jersey.
Emergency medical staff said some of the victims were found with the needle still stuck in their arms. The drug was so powerful that they died before completing the injection, said Dr Stephen Jones, a co- author of the report who is now retired from the CDC, reported Reuters.
The authorities decided to carry out the investigation after receiving a number of reports of overdoses linked to NPF. For instance in April 2006 increases in overdoses among illegal drug users were reported in Camden, New Jersey, which triggered similar reports in other jurisdictions, including Chicago and Detroit, which had been discovered earlier but falsely attributed to heroin overdose until urine samples of some of the dead showed traces of fentanyl.
Thus in May 2006 the CDC started ad-hoc case-finding surveillance in six state and local jurisdictions. This was later taken over by the DEA. This is how the 1,013 NPF related deaths were identified. After this the DEA started regulating access to N-phenethyl-4-piperidone, which is used to make illegal analogs of fentanyl.
The CDC report said the pattern of NPF overdoses points to illegal distribution networks, citing as an example that the NPF found in Chicago and Detroit most likely came from a clandestine production site in Mexico. However, they can't explain why they did not find any NPF-related deaths in other areas of high heroin use, such as in New York City.
As well as the deaths discovered through the CDC/DEA surveillance system, over the same period there were reports of other NPF-related deaths from suburban and rural areas of Illinois, Michigan, and Pennsylvania and in Kentucky, Maine, Maryland, Massachusetts, New Hampshire, Ohio, and Virginia.
The CDC suggested that although the number of NPF-related deaths spotted by the CDC/DEA surveillance system fell substantially in 2007, they predict further epidemics of NPF overdoses are likely because the drug is easier and cheaper to produce than heroin.
Deaths related to heroin and other illicit drugs are well documented in the US. From 1999 to 2005, the figure went up by 87.5 per cent, from 4.0 to 7.5 per 100,000 of the population (age-adjustied deaths from unintentional drug poisoning, mostly linked to pharmaceutical and/or nonpharmaceutical drugs).
The CDC said their report had four limitations: first the figures could be under-reported because for example only participating centers in six jurisdictions were included in the surveillance; second, there is no standard toxicology definition of cause of death for fatal drug overdoses; third, some of the deaths could be misclassified as NPF when they were really pharmaceutical fentanyl-related deaths (ie legal use); and finally, in addition to fentanyl, other substances may have contributed to the overdoses, including alcohol.
Nevertheless, the CDC said the figures are sufficient to warrant improvements in a number of areas relating to drug overdoses. These include improvements in identifying and reporting drug overdose, so law enforcers and public health officials can act more quickly (eg to seize drugs and provide outreach support).
The agency also said there was a need to develop or expand:
* National standards for toxicologic testing and classifying cause of death in drug overdose and poisoning.
* Professional standards for referring overdose surivivors for addiction treatment and education, such as those that exist for suicide survivors.
* Public health programs to help drug users get treatment, be educated about risks of overdose, and learn ways to avoid and deal with overdose.
Jones said in a telephone interview reported by Reuters that the report highlights "an extraordinary episode of fatal drug overdoses".
"But it's got to be recognized as part of the bigger problem of the increasing numbers of drug overdose deaths in the United States," he added.
source: MediLexicon


text:
For a long time I had been a blog writer and some days it took me forever to actually think of a title for the blog post. I could write out a 500 word post without any issues, but I couldn't think of a title that would work out for it.
It can be difficult to think of names for brands in the first place. When we started our photography brand, we named it Be Still Photog. After a while we decided that it would be better branded under our names and called it Ernie and Fiona.
Now we are trying to think of a name for our social media marketing brand that we are starting up and we are wondering what to name it all over again. The first name that we loved the most was FIER. The only meaning behind it was that it still had both of our names in it. Too bad we found someone with the name FIER media and that put that name to rest.
Now I have no idea what to name it. We already have clients and things rolling with it, but we don't have a name for the brand yet.
Someone help us! If you have any ideas, let us know!
We want this brand to be colorful and loud and proud.

subset: commoncrawl


text:
New GFX1011 / GFX1012 Targets Appear In AMDGPU LLVM Compiler Backend [2]
To date the open-source AMD "Navi" graphics code inside their LLVM compiler back-end has been focused on the "GFX1010" target but now it's been branched out to also GFX1011 and GFX1012.
We now know the initial Navi/GFX10 products to be the Radeon RX 5700 and Radeon RX 5700XT. We are still waiting to see the full open-source Linux driver code in full while over the past two days we've seen more AMDGPU LLVM GFX10 code continue to drop.
MoltenVK 1.0.35 Brings Many Additions & Improvements For Vulkan On macOS [3]
It's The Season For Cleaning & Restructuring Within The Intel Linux Kernel Graphics Code [4]
With Intel's Icelake/Gen11 graphics support considered production-ready when on the latest Linux graphics driver components and ahead of the real enablement around their highly anticipated Xe Graphics discrete hardware, it's making for a summer of clean-ups and restructuring within their kernel Direct Rendering Manager (DRM) driver.
There's still bug fixing and other minor work going into the Intel Gen11 Linux graphics driver code (along with new PCI IDs and the like), but now with the driver developers in the period between introducing major generational work and in particular Intel's dGPU plans that will require a lot of new driver code, there's been a lot of low-level code clean-ups and restructuring going on within the i915 DRM driver.


text:
Subjects :: Fiction & Literature Books :: Comics & Graphic Novels Books :: Gay & Lesbian Books
Strangers in Paradise 1
Moore, Terry
Paperback - $16.77More Information
Boy Meets Hero
Avery, Chayne et al
Hardcover - $20.14More Information
Lazarov, Dale et al
Hardcover - $18.84More Information
Stop Bullying Me! / Yaoi
Shino, Natsuho
Paperback - $8.42More Information
The Art of Jaime Hernandez / The Secrets of Life and Death
Hignite, Todd et al
Hardcover - $26.00More Information
Find Your School
Home -
Subjects -
Readers -
Authors & Publishers -
About Us -
ReadersLink™ -
Advanced Search -
Recommended Books -
booksXYZ FAQ -
Publisher Login
Publisher Registration -
Book Listing Levels -
Selling Books -
Book Lister User Agreement -
Printers -
Publisher FAQ -
Helpful Links
Privacy Policy
Visit Our Other Websites
OverNight Prints
and Reaction Design Studios have made very generous donations of printing materials
to booksXYZ and The American Public School Endowments,
to assist us with school relief after Hurricanes Katrina and Rita. Their products are of extremely high quality
at a very low cost, and we cannot recommend them highly enough.
booksXYZ is a nonprofit bookstore, owned and operated by the
Acadiana Educational Endowment (AEE)
and its affiliate, the American Public School Endowments
© Copyright 2002-2019 booksXYZ 412 Travis St., Lafayette, LA 70503
337-769-1471 Fax 337-769-1468 Contact booksXYZ


text:
These scientists have been working to find a safe, non-addictive pain killer to help fight the current opioid crisis in this country – and they may have done just that.
Known as AT-121, the new chemical compound has dual therapeutic action that suppressed the addictive effects of opioids and produced morphine-like analgesic effects in non-human primates.
"In our study, we found AT-121 to be safe and non-addictive, as well as an effective pain medication," said Mei-Chuan Ko, professor of physiology and pharmacology at the School of Medicine.
"In addition, this compound also was effective at blocking abuse potential of prescription opioids, much like buprenorphine does for heroin, so we hope it could be used to treat pain and opioid abuse."
RELATED: FDA Approves First Ever Drug Designed Exclusively to Prevent Migraines
The research, which was conducted by scientists at Wake Forest School of Medicine with the support of the National Institute on Drug Abuse, is published in the journal Science Translational Medicine.
The main objective of this study was to design and test a chemical compound that would work on both the mu opioid receptor, the main component in the most effective prescription pain killers, and the nociceptin receptor, which opposes or blocks the abuse and dependence-related side effects of mu-targeted opioids. Current opioid pain drugs, such as fentanyl and oxycodone, work only on the mu opioid receptor, which also produces unwanted side effects – respiratory depression, abuse potential, increased sensitivity to pain and physical dependence.
"We developed AT-121 that combines both activities in an appropriate balance in one single molecule, which we think is a better pharmaceutical strategy than to have two drugs to be used in combination," Ko said.
MORE: A Woman Given Months to Live From Advanced Breast Cancer is 'Cured' in World First
In the study, the researchers observed that AT-121 showed the same level of pain relief as an opioid, but at a 100-times lower dose than morphine. At that dose, it also blunted the addictive effects of oxycodone, a commonly abused prescription drug.
The bifunctional profile of AT-121 not only gave effective pain relief without abuse potential, it also lacked other opioid side-effects that patients typically struggle with, such as itch, respiratory depression, tolerance and dependence.
Sponsor Suggestion: Try the 15 Best Belgian Beers
"Our data shows that targeting the nociceptin opioid receptor not only dialed down the addictive and other side-effects, it provided effective pain relief," Ko said. "The fact that this data was in nonhuman primates, a closely related species to humans, was also significant because it showed that compounds, such as AT-121, have the translational potential to be a viable opioid alternative or replacement for prescription opioids."
Next steps include conducting additional preclinical studies to collect more safety data, and then if all goes well, applying to the Food and Drug Administration for approval to begin clinical trials in people, Ko said.
(Source: Wake Forest Baptist Medical Center)
Cure Your Friends Of Negativity And Share The Good News With Your Friends – Photo by Ep_jhu, CC


text:
Carrie Etter, a perennial favourite in the bookshop, has released perhaps her most brilliant and original creation yet in the small but perfectly formed chapbook, Scar. Exploring the effects of climate change on her home state of Illinois, the writing crackles and sparks in ominous, but somehow beautiful, dissonance.
The design of a coin is an act of succinct aggrandisement. Bare George, by the incredibly talented poet Claire Crowther, explores the coinage of power through a famous numismatic image: created in 1817 for King George III and his son, the Prince Regent, by celebrity gem designer Benedetto Pistrucci, it pictures young St. George, lancing a dragon.
Join us for a very special evening as these two fabulous poets read and answer your questions.


text: Many people have asked me the possibility of using beads to simulate the sp3 bonding. Indeed, it is possible to create sp3-type bonding in principle, but in practice it is harder than sp2-type chemical bonding. Here is a structure created by Chuang long time ago. I don't even remember whether I have posted it or not.


text:
Install the WordSolver Android App!
2 Definitions of Squinty
The definition of squinty, the meaning of the word Squinty:
Is squinty a scrabble word? Yes!
- adj. - Characterized by squinting
- adj. - (used especially of glances) directed to one side with or as if with doubt or suspicion or envy
Squinty is worth 19 points in Scrabble, and 20 points in Words with Friends
There are 7 letters in squinty: I N Q S T U Y
53 words found using the letters in "Squinty"
6 Letter Words
5 Letter Words
4 Letter Words
3 Letter Words
2 Letter Words


text:
Solange's Words About Owning Your Achievements Are An Important Reminder To All Women
When I think about the idea of girl power, I first think of the Spice Girls. But then, I immediately think of Beyoncé — and now, it's time those words start summoning up her sister, Solange, too. For the latest edition of Interview magazine, Beyoncé interviewed Solange, mainly about her career, and a lot of what she had to say was incredibly inspiring. In fact, Solange's words about being a strong woman are an important reminder about how important it is to own your worth, whether that's in the workplace or not.
During the interview, Beyoncé asked Solange about what misconceptions she's faced in her career as a HBIC, and so much of what she said will ring true for anyone who has ever accomplished something and then, for whatever reason, felt like they should downplay the pride they feel in taking credit for their accomplishment.
Solange said,
"One thing that I constantly have to fight against is not feeling arrogant when I say I wrote every lyric on this album. I still have not been able to say that. That's the first time I've actually ever said it, because of the challenges that we go through when we celebrate our work and our achievements."
For me, this absolutely hits home. There are plenty of times in the past where I've felt uncomfortable accepting a compliment or sharing something I've achieved with people outside of my closest friends and family, but I've never seen any of the men in my life suffer from this phenomenon. It's not fair, and it's a habit that we as women should try to break.
Speaking to her sister, Solange continued,
"It's something I've learned so much about from you, getting to be in control of your own narrative. And, at this point, it should be an expectation, not something that you're asking permission for. I feel like I'm getting closer to that, not taking on all the baggage when I have to just stand up for myself and say, 'No, I'm uncomfortable with that.' And I really appreciate you and mom being examples of that, being able to speak about our achievements, these things that deserve to be celebrated, without feeling bashful about it."
She's right — there's nothing wrong with celebrating yourself or taking control of your own story, so we should all stop feeling like there is. Stars like Beyoncé and Solange are easy to cheer on when they do something awesome like release a killer album or win an award, so we should be cheering ourselves on, too, completely without shame.
Earlier in the interview, Solange also discussed how she's seen her mother and sister "have a hand in" every project they've created; they don't leave any part of an idea they've had up to chance. This can be another tricky thing for women to navigate. From personal experience, I know that the "bossy" label is quick to be handed out if you try to show authority, especially if you're a young woman and especially if you're trying to show that authority over a man. But like Bey herself says, "I'm not bossy, I'm the boss," and Solange seems to echo that sentiment in her interview.
She explained,
"Society labels that a control freak, an obsessive woman, or someone who has an inability to trust her team or to empower other people to do the work, which is completely untrue. There's no way to succeed without having a team and all of the moving parts that help bring it into life."
She's so right, and I plan to take her advice to heart. You're not a control freak if you do want to take control of your story and your own ideas, and I'm so glad that someone with Solange's power is speaking these words into the atmosphere for me and everyone else to absorb.
Basically, if you're not already in love with Solange, be prepared to fall in love after reading this interview — and it's definitely worth a thorough read. She isn't just Beyoncé's little sis, she's a talented, successful woman and musician in her own right. And now more than ever, I think she's someone we should all be learning from.


text:
Jun 26, 2016
It's been almost 2 years but we had Jason back on as a guest again. We talk about the reason why on the on the show in fact. Zack can now drive a car, Blackman killed it at a comedy show and Damien week was someone else week pretty much. Jason did played a song and everyone had Chicken & Shrimp Jambalaya. In the...
Jun 19, 2016
Zack had to work today so we had Ryan Gonyon sub for him. We also have Brian from Paint it Black Studios in. We have an update on the Orlando shooting. Blackman switch the kind of beer he was drinking join open mics. Damien got a shirt that matters to everyone. Blackman was on a few podcast over the weekend. Brian goes...
Jun 12, 2016
We try to have a normal show today but there was to much crazy stuff going on in Orlando. First a singer from The Voice gets shot and then a mass shooting happen right down the road from us a day later. We're still crazy and we do our best to give you a good show but we had to be real for a second at the state of the...
Jun 12, 2016
The unedited speech before the show. We cut down what Damien was saying even after he didn't want us to in the full show. So if you're listening to this you wanted to hear everything he had to say.
Jun 5, 2016
No guest today but still over all fun show. Damien is upset that he could get into the mix on Gay Day. Blackman talk about doing comedy and going to another party. Zack talk about being drunk doing a podcast and watching Popstar. Blackman and Zack got invited to a party and Damien didn't.


text:
We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. In numerous progressive glomerular disease models, treatment with valproic acid (a class I HDAC inhibitor) or SAHA (a pan-HDAC inhibitor) mitigated the degree of proteinuria and glomerulosclerosis, leading to a striking increase in survival. Podocyte HDAC1 and HDAC2 activities were increased in mice podocytopathy models, and podocyte-associated Hdac1 and Hdac2 genetic ablation improved proteinuria and glomerulosclerosis. Podocyte early growth response 1 (EGR1) was increased in proteinuric patients and mice in an HDAC1- and HDAC2-dependent manner. Loss of EGR1 in mice reduced proteinuria and glomerulosclerosis. Longitudinal analysis of the multicenter Veterans Aging Cohort Study demonstrated a 30% reduction in mean annual loss of estimated glomerular filtration rate, and this effect was more pronounced in proteinuric patients receiving valproic acid. These results strongly suggest that inhibition of HDAC1 and HDAC2 activities may suppress the progression of human proteinuric kidney diseases through the regulation of EGR1.
Kazunori Inoue, Geliang Gan, Maria Ciarleglio, Yan Zhang, Xuefei Tian, Christopher E. Pedigo, Corey Cavanaugh, Janet Tate, Ying Wang, Elizabeth Cross, Marwin Groener, Nathan Chai, Zhen Wang, Amy Justice, Zhenhai Zhang, Chirag R. Parikh, Francis P. Wilson, Shuta Ishibe
Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb). Genetic inhibition of PTENK27-polyUb alleviated Col4a3 knockout–, folic acid–, and streptozotocin-induced (STZ-induced) kidney injury. Serum and urine PTENK27-polyUb concentrations were negatively correlated with glomerular filtration rate (GFR) for diabetic patients. Mechanistically, PTENK27-polyUb facilitated dephosphorylation and protein stabilization of TWIST, SNAI1, and YAP in renal epithelial cells, leading to enhanced EMT. We identified that a small molecule, triptolide, inhibited MEX3C-catalyzed PTENK27-polyUb and EMT of renal epithelial cells. Treatment with triptolide reduced TWIST, SNAI1, and YAP concurrently and improved kidney health in Col4a3 knockout–, folic acid–injured disease models and STZ-induced, BTBR ob/ob diabetic nephropathy models. Hence, we demonstrated the important role of PTENK27-polyUb in DKD and a promising therapeutic strategy that inhibited the progression of DKD.
Yajuan Li, Qingsong Hu, Chunlai Li, Ke Liang, Yu Xiang, Heidi Hsiao, Tina K. Nguyen, Peter K. Park, Sergey D. Egranov, Chandrashekar R. Ambati, Nagireddy Putluri, David H. Hawke, Leng Han, Mien-Chie Hung, Farhad R. Danesh, Liuqing Yang, Chunru Lin
The discovery of recurrent mutations in subunits of the vacuolar-type H+-translocating ATPase (v-ATPase) in follicular lymphoma (FL) highlights a role for the amino acid- and energy-sensing pathway to MTOR in the pathogenesis of this disease. Here, through the use of complementary experimental approaches involving mammalian cells and Saccharomyces cerevisiae, we have demonstrated that mutations in the v-ATPase subunit ATP6V1B2/Vma2 activate autophagic flux and maintain MTOR/Tor in an active state. Engineered lymphoma cell lines and primary follicular lymphoma B cells (FL B cells) carrying mutated ATP6V1B2 demonstrated a remarkable ability to survive low leucine concentrations. The treatment of primary FL B cells with inhibitors of autophagy uncovered an addiction for survival for FL B cells harboring ATP6V1B2 mutants. These data support mutational activation of autophagic flux by recurrent hotspot mutations in ATP6V1B2 as an adaptive mechanism in FL pathogenesis and as a new possible therapeutically targetable pathway.
Fangyang Wang, Damián Gatica, Zhang Xiao Ying, Luke F. Peterson, Peter K. Kim, Denzil Bernard, Kamlai Saiya-Cork, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Tycel Phillips, Daniel J. Klionsky, Sami N. Malek
Hyperactivated AKT/mTOR signaling is a hallmark of pancreatic neuroendocrine tumors (PNETs). Drugs targeting this pathway are used clinically but tumor resistance invariably develops. A better understanding of factors regulating AKT/mTOR signaling and PNET pathogenesis is needed to improve current therapies. We discovered that RABL6A, a new oncogenic driver of PNET proliferation, is required for AKT activity. Silencing RABL6A caused PNET cell cycle arrest that coincided with selective loss of AKT-S473 (not T308) phosphorylation and AKT/mTOR inactivation. Restoration of AKT phosphorylation rescued the G1 phase block triggered by RABL6A silencing. Mechanistically, loss of AKT-S473 phosphorylation in RABL6A depleted cells resulted from increased protein phosphatase 2A (PP2A) activity. Inhibition of PP2A restored phosphorylation of AKT-S473 in RABL6A depleted cells whereas PP2A reactivation using a specific small molecule activator of PP2A (SMAP) abolished that phosphorylation. Moreover, SMAP treatment effectively killed PNET cells in a RABL6A-dependent manner and suppressed PNET growth in vivo. This work identifies RABL6A as a new inhibitor of the PP2A tumor suppressor and essential activator of AKT in PNET cells. Our findings offer what we believe is a novel strategy of PP2A reactivation for treatment of PNETs as well as other human cancers driven by RABL6A overexpression and PP2A inactivation.
Shaikamjad Umesalma, Courtney A. Kaemmer, Jordan L. Kohlmeyer, Blake L. Letney, Angela M. Schab, Jacqueline A. Reilly, Ryan M. Sheehy, Jussara Hagen, Nitija Tiwari, Fenghuang Zhan, Mariah R. Leidinger, Thomas M. O'Dorisio, Joseph S. Dillon, Ronald A. Merrill, David K. Meyerholz, Abbey L. Perl, Bart J. Brown, Terry A. Braun, Aaron T. Scott, Timothy Ginader, Agshin F. Taghiyev, Gideon K. Zamba, James R. Howe, Stefan Strack, Andrew M. Bellizzi, Goutham Narla, Benjamin W. Darbro, Frederick W. Quelle, Dawn E. Quelle
MAPK4 is an atypical MAPK. Currently, little is known about its physiological function and involvement in diseases, including cancer. A comprehensive analysis of 8887 gene expression profiles in The Cancer Genome Atlas (TCGA) revealed that MAPK4 overexpression correlates with decreased overall survival, with particularly marked survival effects in patients with lung adenocarcinoma, bladder cancer, low-grade glioma, and thyroid carcinoma. Interestingly, human tumor MAPK4 overexpression also correlated with phosphorylation of AKT, 4E-BP1, and p70S6K, independent of the loss of PTEN or mutation of PIK3CA. This led us to examine whether MAPK4 activates the key metabolic, prosurvival, and proliferative kinase AKT and mTORC1 signaling, independent of the canonical PI3K pathway. We found that MAPK4 activated AKT via a novel, concerted mechanism independent of PI3K. Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth. We concluded that MAPK4 can promote cancer by activating the AKT/mTOR signaling pathway and that targeting MAPK4 may provide a novel therapeutic approach for cancer.
Wei Wang, Tao Shen, Bingning Dong, Chad J. Creighton, Yanling Meng, Wolong Zhou, Qing Shi, Hao Zhou, Yinjie Zhang, David D. Moore, Feng Yang
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-κB–driven proinflammatory gene expression independently of the liberation of RAGE ligands or the ligand-binding ectodomain of RAGE. The importance of this transactivation pathway was demonstrated by our finding that adverse proinflammatory signaling events induced by AT1 receptor activation were attenuated when RAGE was deleted or transactivation of its cytosolic tail was inhibited. At the same time, classical homeostatic Gq signaling pathways were unaffected by RAGE deletion or inhibition. These data position RAGE transactivation by the AT1 receptor as a target for vasculoprotective interventions. As proof of concept, we showed that treatment with the mutant RAGE peptide S391A-RAGE362–404 was able to inhibit transactivation of RAGE and attenuate Ang II–dependent inflammation and atherogenesis. Furthermore, treatment with WT RAGE362–404 restored Ang II–dependent atherogenesis in Ager/Apoe-KO mice, without restoring ligand-mediated signaling via RAGE, suggesting that the major effector of RAGE activation was its transactivation.
Raelene J. Pickering, Christos Tikellis, Carlos J. Rosado, Despina Tsorotes, Alexandra Dimitropoulos, Monique Smith, Olivier Huet, Ruth M. Seeber, Rekhati Abhayawardana, Elizabeth K.M. Johnstone, Jonathan Golledge, Yutang Wang, Karin A. Jandeleit-Dahm, Mark E. Cooper, Kevin D.G. Pfleger, Merlin C. Thomas
Energy stress, such as ischemia, induces mitochondrial damage and death in the heart. Degradation of damaged mitochondria by mitophagy is essential for the maintenance of healthy mitochondria and survival. Here we show that mitophagy during myocardial ischemia was mediated predominantly through autophagy characterized by Rab9-associated autophagosomes, rather than the well-characterized form of autophagy that is dependent upon the Atg-conjugation system and LC3. This form of mitophagy played an essential role in protecting the heart against ischemia and was mediated by a protein complex consisting of Ulk1, Rab9, Rip1 and Drp1. This complex allowed recruitment of trans-Golgi membranes associated with Rab9 to damaged mitochondria through Ser179 phosphorylation of Rab9 by Ulk1 and Ser616 phosphorylation of Drp1 by Rip1. Knock-in of Rab9 (S179A) abolished mitophagy and exacerbated injury in response to myocardial ischemia without affecting conventional autophagy. Mitophagy mediated through the Ulk1-Rab9-Rip1-Drp1 pathway protected the heart against ischemia by maintaining healthy mitochondria.
Toshiro Saito, Jihoon Nah, Shin-ichi Oka, Risa Mukai, Yoshiya Monden, Yusuhiro Maejima, Yoshiyuki Ikeda, Sebastiano Sciarretta, Tong Liu, Hong Li, Erdene Baljinnyam, Diego Fraidenraich, Luke Fritzky, Peiyong Zhai, Shizuko Ichinose, Mitsuaki Isobe, Chiao-Po Hsu, Mondira Kundu, Junichi Sadoshima
Peroxisomes perform essential functions in lipid metabolism, including fatty acid oxidation and plasmalogen synthesis. Here, we describe a role for peroxisomal lipid metabolism in mitochondrial dynamics in brown and beige adipocytes. Adipose tissue peroxisomal biogenesis was induced in response to cold exposure through activation of the thermogenic co-regulator PRDM16. Adipose-specific knockout of the peroxisomal biogenesis factor Pex16 (Pex16-AKO) in mice impaired cold tolerance, decreased energy expenditure, and increased diet-induced obesity. Pex16 deficiency blocked cold-induced mitochondrial fission, decreased mitochondrial copy number, and caused mitochondrial dysfunction. Adipose-specific knockout of the peroxisomal beta-oxidation enzyme acyl CoA oxidase 1 (Acox1-AKO) was not sufficient to affect adiposity, thermogenesis or mitochondrial copy number, but knockdown of the plasmalogen synthetic enzyme glyceronephosphate O-acyltransferase (GNPAT) recapitulated the effects of Pex16 inactivation on mitochondrial morphology and function. Plasmalogens are present in mitochondria and decreased with Pex16 inactivation. Their dietary supplementation increased mitochondrial copy number, improved mitochondrial function, and rescued thermogenesis in Pex16-AKO mice. These findings support a surprising interaction between peroxisomes and mitochondria to regulate mitochondrial dynamics and thermogenesis.
Hongsuk Park, Anyuan He, Min Tan, Jordan M. Johnson, John M. Dean, Terri A. Pietka, Yali Chen, Xiangyu Zhang, Fong-Fu Hsu, Babak Razani, Katsuhiko Funai, Irfan J. Lodhi
Loss of phosphatase and tensin homolog (PTEN) represents one hallmark of prostate cancer (PCa). However, restoration of PTEN or inhibition of the activated PI3K-AKT pathway has shown limited success, prompting us to identify obligate targets for disease intervention. We hypothesized that PTEN loss might expose cells to unique epigenetic vulnerabilities. Here, we identified a synthetic lethal relationship between PTEN and BRG1, an ATPase subunit of the SWI/SNF chromatin remodeling complex. Higher BRG1 expression in tumors with low PTEN expression was associated with a worse clinical outcome. Genetically engineered mice (GEMs) and organoid assays confirmed that ablation of PTEN sensitized the cells to BRG1 depletion. Mechanistically, PTEN loss stabilized BRG1 protein through the inhibition of the AKT-GSK3β-FBXW7 axis. Increased BRG1 expression in PTEN-deficient PCa cells led to chromatin remodeling into configurations that drive a protumorigenic transcriptome, causing cells to become further addicted to BRG1. Furthermore, we showed in preclinical models that BRG1 antagonist selectively inhibited the progression of PTEN-deficient prostate tumors. Together, our results highlight the synthetic lethal relationship between PTEN and BRG1, and support targeting BRG1 as an effective approach to the treatment of PTEN-deficient PCa.
Yufeng Ding, Ni Li, Baijun Dong, Wangxin Guo, Hui Wei, Qilong Chen, Huairui Yuan, Ying Han, Hanwen Chang, Shan Kan, Xuege Wang, Qiang Pan, Ping Wu, Chao Peng, Tong Qiu, Qintong Li, Dong Gao, Wei Xue, Jun Qin
Abnormal alternative splicing (AS) caused by alterations of splicing factors contributes to tumor progression. Serine/arginine splicing factor 1 (SRSF1) has emerged as a key oncodriver in numerous solid tumors, leaving its roles and mechanisms largely obscure in glioma. Herein we demonstrated that SRSF1 was increased in glioma tissues and cell lines. Moreover, its expression was correlated positively with tumor grade and Ki-67 index, but inversely with patients' survival. Using RNA-seq, we comprehensively screened and identified multiple SRSF1-affected AS events. Motif analysis revealed a position-dependent modulation of AS by SRSF1 in glioma. Functionally, we verified that SRSF1 promoted cell proliferation, survival and invasion by specifically switching the AS of myosin IB (MYO1B) gene and facilitating the expression of the oncogenic and membrane-localized isoform, MYO1B-fl. Strikingly, MYO1B splicing was dysregulated in parallel with SRSF1 expression in gliomas, and predicted the poor prognosis of the patients. Further investigation revealed that SRSF1-guided AS of MYO1B gene increased the tumorigenic potentials of glioma cells through the PDK1/AKT and PAK/LIMK pathways. Taken together, we identify SRSF1 as an important oncodriver, which integrates the AS controlling of MYO1B into promotion of gliomagenesis, and represents a potential prognostic biomarker and target for glioma therapy.
Xuexia Zhou, Run Wang, Xuebing Li, Lin Yu, Dan Hua, Cuiyun Sun, Cuijuan Shi, Wenjun Luo, Chun Rao, Zhendong Jiang, Ying Feng, Qian Wang, Shizhu Yu
No posts were found with this tag.


text:
The same moms that smear peanut butter on bread, sometimes
the white center and patching it with a little spit,
the same moms who hold hair back from faces throwing up
into bowls
and later sit with their kids at bedtime, never long enough at first,
and then inevitably overtime, grabbing on to a hand
as if they could win out against the pull on the other side,
the world's spin and winds and tides,
all of it in cahoots with sex to pull the kid into another orbit,
these moms will go out, maybe in pairs, sometimes in groups,
and leave their kids with dads and fast food, something greasy
they eat with their fingers, later miniature golf, maybe a movie,
a walk with the dog in the dog park,
where one night a kid sees an old mutt riding in a stroller,
invalid, on its back, its paws up, cute like that, half begging,
half swoon,
and this kid, who once told her mom she knew what dads did
on poker nights–
"They're guys, they'll just deal the cards and quarrel"–
starts to wonder what moms do out together, whether they talk
about their kids,
their little rosebuds, their little night-lights,
or are they taking about their bodies and what they did with them
in Portugal, Hawaii, the coast of France, it's better than cards,
it's anatomy and geography, they're all over the map,
or maybe not talking but dancing–
to oldies? light rock? merengue? Would they dare dance
with men, with men in vests? in earmuffs? forget earmuffs!
top hats, younger men in sneakers who catch their eye from across
the room.
Now they're singing. Where have they kept the words to so many
storing them up like secrets, hidden candy, the words melting
in their mouths,
chocolate, caramels, taffy,
the next thing you know they'll be drinking–or are they already
on to a third bottle, some unaffordable Nebbiolo
from the Piedmont, red wine named after the region's fog
and aging into a hint of truffles.
Soon two of them will walk off together, laughing,
their mouths open too wide, their shoulders, no their whole bodies
shaking, the way a bear would laugh after it ate you,
heartily, remorselessly, they laugh all the way to the bathroom,
where together in mirrors they try to keep a straight face
so they can put on lipstick the crimson of the sun sinking into
the bay.
They blot their red mouths on tissues they toss
over their shoulders, leaving the impressions of their lips behind
on the floor for a tired woman in a grey dress who'll lift them
to the trash,
not noticing the mom's lips, not wondering for even a heartbeat
if the kisses there meant hello or good-bye.
Wordy Wednesday: Secret Lives by Barbara Ras
The same moms that smear peanut butter on bread, sometimes


text:
This week's Friday Price Drop sees the HD collection of three of the most recent (and finest) Tomb Raider games – Legend, Anniversary and Underworld – hitting a brand new low price. The Tomb Raider Trilogy collection – currently a PS3 exclusive – is available now for just £9.85. The disc also contains a PS3 theme pack, two avatar outfits and a small collection of 'Making of' trailers.
Also available this week is the crackerjack, all-female 2D fighting game Arcana Heart 3. It's available on both Playstation 3 and Xbox 360 for just £17.85 on either format.
To see a full list of this week's Price Drop offers, click here.
Watch the trailer for Arcana Heart 3 here:


text:
Plumber Concord
Your local Concord plumbing experts
Need a reliable Concord plumber? When something unexpected happens to your Concord plumbing, turn to JAB Plumbing Solutions. Our plumbers are locally based in Concord and we have a long history of providing quality services at an affordable price. Our team of plumbers specialise in blocked drains and sewer cleaning. With the use of the latest high-tech plumbing equipment, our Concord plumbers can solve your drainage issues quickly and thoroughly. If you're having an issue with water backing up in your sink, shower or bath, give our Concord plumbing team a call and see how we can help. See what your friends and neighbours are saying about our work with our online reviews.
The Concord plumbers you can count on
We give you the full price, upfront with no hidden fees
We respect your home and always leave it clean, safe and protected
All our work is guaranteed and carried out to the highest standard
Our team is on call 24/7 to help with emergencies as soon as they arise
We are fully licensed to carry out work in the safest possible manner
We know your time is valuable so we guarantee to arrive on time
Concord Blocked drain plumbers
If you have a seriously clogged drain, you should call a Concord plumber for a drain cleaning service. We have the right equipment and knowledge to repair blocked drains fast. Our team will also recommend strategies to prevent future blockages from occurring. Call 1800 225 552 to speak with our Concord plumber today.
Our Concord plumbers use the latest water jetters on the market. Jet blasters use high-pressured water to cut through stubborn blockages including grease, tree roots and mineral deposits. Jetters are perhaps the most effective method for cleaning drains, because they clean the interior lining of the pipe without any chemicals.
Is your bathroom unusable because of a toilet that won't flush? Blocked toilets are often caused by sanitary items, cotton balls, makeup wipes, wet-wipes and other flushed debris. Our Concord plumbers use the latest plumbing equipment to clear clogged toilets fast. Phone our Concord plumbing team on 1800 225 552.
When it comes to blocked sewers, time is of the essence. You need a Concord plumber to attend to your issue immediately, as it can cause further damage the longer it's left. JAB Plumbing Solutions offer our customers the security of a 24 hour emergency plumber in Concord for blocked sewer disasters. Call 1800 225 552 now.
If you were happy with our plumber Concord please take a moment to leave us a review. We are always looking for ways to improve our service and your feedback is valued! Simply click on your preferred platform below. Thanks!
Our plumbers service THE entire INNER WEST
| Abbotsford | Annandale | Ashbury | Ashfield | Balmain | Birchgrove | Burwood | Burwood Heights | Cabarita | Canada Bay | Chiswick | Concord West | Croydon | Croydon Park | Drummoyne | Dulwich Hill | Earlwood | Enfield | Enmore | Erskineville | Eveleigh | Five Dock | Forest Lodge | Gladesville | Glebe | Haberfield | Homebush | Leichhardt | Lewisham | Lilyfield | Marrickville | Mortlake | Newtown | North Strathfield | Petersham | Rhodes | Rozelle | Rodd Point | Russell Lea | St Peters | Stanmore | Strathfield | Strathfield South | Summer Hill | Sydenham | Tempe | Wareemba | Wentworth Point |


text:
A post mortem on the Icelandic banking failures
Just yesterday, a Special Investigation Commission report was released in Iceland which criticized the handling of the country's top three banks and the crisis that ensued when they collapsed. Seven top officials were said to have acted with "gross negligence" in allowing the collapse.
An official report yesterday accused the Icelandic government and regulators of "extreme negligence" in the run-up to the country's 2008 banking crisis.
Geir Haarde, former prime minister, and David Oddsson, former prime minister and central bank governor, were among those blamed for the crash.
The independent "truth commission" appointed by parliament to investigate the crisis also pointed to possible illegality within the banks, including share price manipulation and exaggeration of asset values.
The 2,000-page report marks the most in-depth account to date of how one of the world's wealthiest economies was brought to the brink of bankruptcy in October 2008 by the collapse of its three main commercial banks.
The commission criticised regulators for failing to rein in the banks – Landsbanki, Glitnir and Kaupthing – as they grew 20-fold in size between 2001 and 2008 until their liabilities far exceeded the country's ability to bail them out.
Unfortunately, to my knowledge, the full report is not available in English yet (not that you'd want to read it anyway). But, I do have two documents below that the Commission did release in English.
- Iceland's Failed Banks: A Post-Mortem
- Icelandic Deposits in Financial Institutions in Branches abroad
They are also embedded below. Enjoy.
Also see "Some Saga: On Web, Icelandic Actors Are Reading 2,000-Page Bank Crisis Report" from NPR. Apparently, some Icelanders are reading this mammoth 2,300 page report on the Internet. Maybe some Americans should do the same with the Lehman report.
Iceland's Failed Banks: A Post-Mortem
Icelandic Deposits in Financial Institutions in Branches abroad


text:
The process of cell division in plants and animals is very similar as regards the replication and separation of the nucleus and other organelles, but the actual process of dividing the cytoplasm differs. In animal cells, the cytoplasm of the two daughter cells is essentially pinched apart by a ring of actin and myosin proteins pulling the cell membrane closed. Plant cells separate their cytoplasm by building a wall instead.
The process of cell division is completed in five stages. One is able to remind themselves of the stages with the abbreviation PMATI. The phases of cell division this abbreviation represents are prophase, metaphase, anaphase, telophase and interphase.
Prophase is the preparation for cell division. The cell replicates its DNA and arranges centrioles properly for division. During metaphase, the cells continues to align other parts of itself for division, and the DNA condenses into chromosomes. Anaphase is when the real action happens. The chromosomes separate to opposite sides of the cell, and the splitting begins. Telophase is when the membrane of the cells closes around the new, separate cells. Interphase is the resting of the cell. During this phase, it focuses on surviving and preparing for a future cell division.
The two types of cell division in plant and animal cells are mitosis and meiosis. Mitosis is the basic type of cell division that tissues use to grow and replenish themselves, and which single-celled eukaryotes use to reproduce. Meiosis is the type of cell division plants and animals use to produce gametes for sexual reproduction. The steps of both types are basically the same, except that the production of gametes halves the genetic information in each resulting cell. The resulting gametes are often very different from their parent cells in form.
Regardless of the type of cell division, the process of actually dividing the cytoplasm, known as cytokinesis, remains similar The method of cell division used by animals, which involves a contracting ring of proteins, is shared by many single-celled organisms as well.


text: Cannondale SUPERSIXWhat a lightweight road race bike can be.Learn More Cannondale SYNAPSELightweight & comfortable, ride faster & longer.Learn More Cannondale SYSTEMSIXThe aerodynamic advantage will make you faster.Learn More Cannondale TOPSTONEThe Topstone is pure gravel goodness.Learn More Giant DEFYThe pinnacle of endurance road perfromance.Learn More LIV AVAILLight, comfortable & engineered for female riders.Learn More Giant TCR ADVANCEDAn efficient and total race bike.Learn More Specialized ALLEZThe perfect choice for all levels of road cyclists.Learn More Specialized DIVERGERoad, gravel or endurance bike? You decide.Learn More Specialized ROUBAIXThe best example of an endurance road bike.Learn More Specialized SIRRUSCity bike. Urban bike. Your everyday regular bike.Learn More Specialized TARMACStiff, yet compliant, snappy, yet aero, and fast.Learn More Cannondale HABITThe best example of an endurance road bike.Learn More Giant REVOLTCity bike. Urban bike. Your everyday regular bike.Learn More Jamis RENEGADEDefining versatility in the modern adventure bike.Learn More


text:
If any CHPAMS member needs to spend money on CHPAMS-related business activities, the member has to apply for the budget with the request form in advance. The amount requested is estimated based on the applicant's best information.
Based on the bylaws (Section 6.10), President, Secretary, or Treasurer are the officers to maintain the daily operation and any of them can approve the budget request. Based on the bylaws (Section 9.5), if the requested amount is over $500, 2/3 of the Board has to approve.
Once the budget is approved, the applicant can spend the money and submit the reimbursement form with receipts or other supporting documents.
Another officer (President, Secretary, or Treasurer), who is different from the officer who approves the budget, verifies the amount and approves the reimbursement. Therefore, any transaction will be approved by at least two officers. Based on the bylaws (Section 6.4), only President and Treasurer can write a check, so only these two officers can approve the reimbursement. Once approved, a reimbursement check will be issued. If President or Treasurer applies for the budget, another officer needs to approve the request in advance.
If there is any issue in the process, the officers will try to resolve in the first place. If there is dispute between the officers, the Board will review and settle the case.


text:
Please like us on Facebook!
Follow us on TwitterMy Tweets
For more information
Tag Archives: montrell wade
HCMC marks 25 years of Level I Trauma care
In 1989, Hennepin County Medical Center HCMC) was the first hospital in Minnesota – and one of the first in the country – to be verified by the American College of Surgeons (ACS) as a Level I Trauma Center. This … Continue reading
Posted in HCMC News, HCMC Press Releases Tagged 25 years, acs, american college of surgeons, art ney, brynn duncan, chad richardson, critical, emergency, fracture, level 1 pediatric trauma center, level I trauma center, montrell wade, officer mike blood, orthopedic, schild, survival, troske, verification


text:
I have the great providence of being surrounded by inspiring people. 5 for Friday questions will be asked of artists, farmers, curators, creators, innovators, entrepreneurs etc – all of the people that I find interesting. Everyone gets the same five questions.
I met Kari Gran (pictured left) through my dear friend Carilyn, who was hired to do PR for her then-new skincare line. She co-founded her company, aptly named Kari Gran, with her friend, Lisa Strain - two ladies moving' and shakin' to introduce their line of products. On the top floor of a gorgeous and airy loft overlooking Lake Union, Kari showed me how to wash my face with oils, talked to me about the benefit of using oil-based cleansers and moisturizers, and in general charmed me with her easy going yet educated approach to daily skincare. After sending me home with a small sample size of the line, I was hooked. Within two weeks, I received compliments from friends on how great I looked. How refreshed. My friend Nga actually said to me "Brooky, your skin is glowing." I was hooked.
Kari created her skincare products as a result of an auto-immune diagnosis. She found traditional ingredients in off-the-shelf cleansers to be irritants. After much research, she decided to create her own personal products using only simple, organic ingredients. After years of passing homemade concoctions out as small hostess gifts to friends, she launched the business. [I'm oversimplifying, but you can read the story here.] And isn't that always how the coolest companies start?!! It's almost as if she didn't mean to do it - one thing led to another and BOOM - she has a successful and growing business.
From the moment I met Kari she has been a shining light. She has AMAZING skin herself and is always so well put together, that I make a mental note every time I see her. (Ditto for Lisa - they are a force.) I go to the studio directly to buy their products, as I love the social catch up. We have often mused over event ideas, gardening plans and life's interesting twists and turns. One day we'll organize enough to have a dual herbal event of some kind - stay tuned. And of course, the products are available online. And as I learned late last year when I forgot to pack my products on an extended trip to NY - they ship. Meet Kari Gran…..
1. What did you eat for breakfast this morning? Leftover black bean chili and basmati rice with a fruit smoothie chaser. And coffee, of course.
2. What is one thing you do EVERY day, by choice? Meditate. Learned TM this summer and haven't looked back.
3. If you had all the time in the world and no budget restrictions, what one project would you take on just now? (Can be a hobby, business, trip, etc) I would love to simply have the time, in the crazy swirl of a start-up, to sit and think about it (all). But something that touched me recently in a very profound way, was the opportunity to meet with the founders of Wonderwork while in NYC on a business trip in April and get a peek at what they are doing with miracle surgeries. Many of (the surgeries) are so incredibly quick and inexpensive, but life altering for the children who receive them. We made our first donation from the company of our gross (revenue) and as we grow, the money we donate will increase, as well. At the end of the day, it really doesn't take much to make a big difference, every little bit counts. It's our vision of real beauty. I wish I could add another 24 hours to my day so that I could work for them in all my spare time!
4. Where is your 'happy place'? The last five minutes of yoga class, laid out flat on my back in Savasana with an eye pillow and blanket. My 45 year old version of the kindergarten nap.
5. What is your signature dish - something you make well and consistently? Carrot cake with cream cheese frosting. I've been doing it since the late 80's and it's got a bit of a cult following!
[amyp note - Lest you leave here thinking I'm a high roller, I'll be the first to warn you that these products are not cheap. In fact, the first time I bought them I felt a little sick. BUT……..they changed my skin, they last a long time (I only buy 3 to 4 times a year) and I'm almost 40 and consider it an investment. This is ONE of a very-few products I believe to be very-much worth the splurge.]


text:
The Precious Metals Storage Account is composed of Euro Pacific Bank's government guaranteed, physical gold and silver accounts, giving you the security of physical precious metals while providing the convenience and access of a private bank.
Buying and storing precious metals
Easily convert cash in your bank account into physical gold and/or silver following the steps below. Note that purchases must be made in USD or AUD, so if you have another currency please use the Currency Conversion tool in your Online Banking.
1. Log into your Online Banking > Accounts screen > Precious Metals Accounts section > Trade Precious Metals button.
2. Select the type of metal you would like to convert into (XAU or XAG), from your USD or AUD balance.
3. You have a choice of two order methods: Instant Fill and Delayed Fill. See Commission Rates for each method.
- Instant Fill Order – Fixed commission, however your order can be placed and executed instantly 24/7 at the market rate.
- Delayed Fill Order – Because we only fill delayed orders during The Perth Mint's morning trading hours, Delayed Fill Orders have a reduced commission. The minimum for a Delayed Fill Order is $5,000.00.
Selling your precious metals
At any time, you may liquidate a portion or all of your precious metals holdings using the same process outlined above, and your cash proceeds will be deposited back into your bank account within one business day.


text:
Welcome to the TweakTown Forums.
There are currently 25382 users online. 30 members and 25352 guests
Most users ever online was 30,074, 2 Days Ago at 03:57 PM.
1429894 Spammers Denied Registration
2025 Spammers Permanently Banned
2055 Spammers submitted to StopForumSpam
238 Spammers submitted to Akismet
3131 Spammy Posts Automatically Moderated
Welcome to our newest member, kontaazul


text:
Cabo da Roca lisbon wedding photographer – Slideshow of Alina and Vitaly
Alina & Vitaly wedding gallery will be available online really soon!!!!
Visit the next link for the gallery online. Use the date (dd-mm-yyyy) as password.
Order prints and free individuals downloads are available. Full gallery download only for the couple.
Below is the slideshow of their amazing day. Thanks for having me along for the day – it was amazing!


text:
Following the deadly attack on a nightclub in Istanbul, security experts say that terror attacks will continue to set the agenda in Turkey in 2017. The government's policy in Iraq and Syria plays a significant role.
In the wake of Turkey's failed coup in July, the government launched a military incursion into neighboring Syria to clear "Islamic State" (IS) terrorist militia fighters from its border. Turkey has also stepped up its campaign against Kurdish militants in the country's southeast as well as northern Iraq. Experts told DW both IS and the Kurdistan Worker's Party, or PKK, pose a threat to Turkey.
"The resolution about Syria goes [over] well, but there is a hidden side to it. There is a huge fight between the US and Russia west of the Euphrates and this fight has reached a climax as high as in the Cold War days," said Ibrahim Cevik, a security and terror expert at the Turkish Centre for International Relations & Strategic Analysis (TURKSAM). "The lack of control in Syria, the fact that guns lack control and terrorists are walking freely, will hurt us more."
Syria, Iraq policy
Turkey and Russia brokered a ceasefire deal between Syrian government and opposition forces that took effect on December 30. The country has been embroiled in civil war since 2011, and the conflict has had a direct impact on the security of neighboring Turkey.
The Iraqi army, meanwhile, is attempting to recapture IS-controlled Mosul. Ankara considers the situation in the city a significant threat to its national security, and has sought to take on a larger role in the operation.
Nihat Ali Ozcan, a security and PKK expert at the TOBB University of Economics and Technology, said that 2017 will not be a good year for Turkey "because the ecosystem in the region - in Iraq and Syria [specifically] - is changing very quickly and there are reasons related to that."
"Secondly, there are many terror organizations active in Turkey and they target each other, the state and the public," he said. "Both PKK and [IS] and on the other side the [banned far-left] Revolutionary People's Liberation Party-Front (DHKP-C) - they are all active."
The United States, the European Union and Turkey list the DHKP-C group as a terrorist organization.
Crackdown sparks backlash
Ozcan said the government purge following the July 15 coup attempt could also pose a security threat.
"There are some problems with the state institutions responsible for preventing this. Many people have been suspended, reassigned, reappointed or arrested in the gendarmerie, the army, the police, the judiciary and the penal institutions due to [alleged ties with] the Gulen movement," he said.
President Recep Tayyip Erdogan has accused US-based cleric Fethullah Gulen of being behind the failed coup.
Ozcan said that the government has politicized important government positions all the way up to the presidency. "When you put all of this together, I think this year security will be a significant problem for us," he said.
The Council of Europe, the continent's 's leading human rights organization with 47 member states including Turkey, said last month that over 125,000 people in the country had been dismissed from their jobs as of December 9, and almost 40,000 people had been arrested amid the government purge.
'Signal' for 2017
Mesut Hakki Casin, a professor of International Relations at Ozyegin University Faculty of Law and an international terrorism and security strategy expert, said that the precision of the New Year's Eve attack on a nightclub in Istanbul, which left 39 people dead, suggested to him that it was planned, and the fact that it was done after midnight sends a clear message for 2017.
"I think it gives a signal that in 2017 terror will disturb Turkey," he said. "I think it was an organized attack… For the first time an entertainment venue has been targeted in Turkey."
IS on Monday claimed responsibility for the attack, which was carried out by a lone gunman still at large. The militant group said it was revenge for Turkish military involvement in Syria and described the targeted nightclub as a gathering point for Christians celebrating their "apostate holiday."
Turkey has been shaken by numerous terrorist attacks in the past year-and-a-half and IS has been blamed for at least half a dozen of them.
IS has taken credit for numerous attacks abroad as it fights to hold onto territory in Syria and Iraq
Kurdish tension
Last month, two bombs exploded outside a soccer stadium in Istanbul, killing 44 people. A car bomb killed at least 13 soldiers a week later in the central city of Kayseri. Kurdish militants claimed responsibility for both of the attacks.
Since a two-and-a-half-year ceasefire ended in July 2015, Turkey has continued to clash with militants from the PKK, which is labeled a terrorist organization by the US, EU and Turkey, in the southeast.
Tensions flared recently after lawmakers from the country's main pro-Kurdish Peoples' Democratic Party (HDP) were arrested and local HDP mayors in the southeast were detained and replaced by government officials.
Ozcan said that he expected the PKK to escalate its attacks in the spring.
"In terms of the PKK issue, it looks like tensions will increase as well as the clashes," he said. "Towards the spring, the trend could increase. It was calm due to weather conditions."
"Islamic State" (IS) has claimed responsibility for the attack on the upscale Istanbul nightclub that left 39 people dead, reportedly including at least two Germans. Turkish police are still searching for the gunman. (01.01.2017)
A controversial reform that would significantly expand Turkish President Erdogan's power has passed another hurdle. Now parliament will vote on whether a constitutional referendum will go forward. (30.12.2016)
Airstrikes in parts of Syria have threatened an unstable truce brokered by Russia and Turkey. Hundreds of people have also fled a mountainous region near Damascus, where government forces were battling insurgent groups. (01.01.2017)
Turkish journalist and writer Ahmet Sik has been formally charged with spreading "terror propaganda" by an Istanbul court. More than 80 journalists are behind bars in Turkey following a failed coup in July. (31.12.2016)


text:
[Skip to content]
Teledyne Dalsa has launched its Genie Nano-M2450 polarised camera built around Sony's Pregius 5.1M polarised image sensor. The model features a monochrome quad polarisation filter, resolution of 2448 x 2048 pixels, and aims to deliver an image capture of 35 frames per second. The product also utilises the company's TurboDrive technology with the intention of increasing frame rates by up to 50%. Additionally, the device is said to offer polarisation for both area and line scan (Piranha 4 polarisation) cameras. Polarisation enables detectability of stress, birefringence, through-reflection and glare from surfaces like glass, plastic and metal.


text:
Join a community of over
9 million members!
in Cash and Rewards redeemed
since 2007!
in paid online surveys right now!
Gift Card Rewards to choose from
in cash and rewards paid today
Since 2007, we've strived to be different. Making customer service our #1 priority and offering instant rewards processing so you get paid fast, PrizeRebel.com is one of the most trusted online survey sites with over 9 million members and counting. We work with the biggest global market research companies to provide you with the highest quality paid online surveys that you can complete to make money at home and earn gift cards.
Don't wait, SIGN UP FOR FREE today!
Thabks Prizerebel.I got this prize after two weeks of hard-earning work.I've been a loyal Prizerebel user since 2010 and I have no regrets!Thanks for the awesome game,I played it very much thanks to you!!
Surpassing my expectations for online rewards websites, PrizeRebel.com has become an exceptional side hobby to assist me in a time of hardship. I have already accumulated a significant amount of points for my next rewards claim. Professional and prompt support are available through a number of means. I would recommend PrizeRebel.com to anyone ...
I am so happy that I came across and found Prize Rebel. Getting paid to do surveys, i literally never thought I would see the day that I would get paid to do them, how awesome is that! Thank you so much! I know it's not much, but it will defitnely help putting the money towards those unexpected rainy days. So once again thank you from the bott...
There is no doubt Prize Rebel is the number one website for online surveys. Surveys are constantly being updated, so your chance of receiving rewards are high. The best part is that you have a wide range of reward options with effectively immediate payment! My paypal balance is on the up and up! Thanks Prize Rebel.


text:
And the Winner of This Weekends PGA Championship Will Be …
According to ESPN's experts, not Tiger.
On Thursday, a star-studded feature group including Tiger Woods, Rory McIlroy, and Justin Thomas will tee off together at the 2018 PGA Championship.
Out of those three, a panel of ESPN golf experts including Bob Harig, Ian O'Connor, Michael Collins, Kevin Van Valkenburg, Nick Pietruszkiewicz, and Matt Barrie predict two have a chance at winning it all.
Unfortunately for the tournament's TV ratings, one of them isn't Tiger.
The fourth major of the year -which has a massive 156-man field – has seen big names and no-names capture its top spot and this year will likely be no different.
Still, considering this year's field has 110 of the top 112 golfers in the world, the winner is more than likely going to be someone you know rather than someone you don't.
According to ESPN's panel, Thomas, McIlroy, Patrick Cantlay, Jordan Spieth, and Justin Thomas all have a shot to win.
But, the golfer who was picked more than any other was 28-year-old Tony Finau.
Guess we'll see starting tomorrow. Hopefully, Woods proves 'em wrong.
The Best Stuff on the Web, Curated
Daily Brief
15 Things to Know Today, from RealClearLife
The Best Stuff on the Web, Curated
Daily Brief
Everything to Know, via RealClearLife


text:
Smartphones have more or less revolutionized the modern world. We use it for anything from calling people to controlling our TVs; it has even replaced actual cameras for a lot of us. In 2014 alone, over a billion were sold. Statistically speaking, over 1 in every 7 people has a Smartphone. That is incredible. In fact, it's impossible to get on a bus and not find a Smartphone user.
We can all agree that the biggest draw for Smartphones is the apps. Whether it is the utility apps, business productivity ones or social media apps, they work amazingly well and offer you tools that increase your productivity. There are 5 ways that Smartphones can help increase productivity, on Android or iOS.
There are numerous apps that can be downloaded to jot down notes and save reminders (in most Smartphones, there are built-in apps like "Action Memo" for Galaxy Note, and "Reminders" and "Notes" for iOS). The advantage this has over writing normal notes on a piece of paper is that you're not going to forget or lose them. If you set a reminder on your phone, your phone lets you know when you need to take a particular action or even 10 minutes ahead depending it on when you like them. You'd be surprised how much this has helped me when buying groceries.
Messages are no longer just the familiar SMS, they include WhatsApp, Viber, Line and even e-mails. The apps are made for easy and fast communication which are useful traits when you are busy working hard. You can ask questions, provide answers, send documents , all in a matter of seconds. It saves time and lets you get on with more important work. One can't always find the time or the energy to type so voice and video messages come to your rescue.
One of the key differences between the older phones and current generation Smartphones is the lack of a physical-button keyboard. You need a software keyboard and there are a ton of them available, check Google Play out for these. These keyboards actually improve speed, recognize the way you type, make accurate predictions based on what you type, they auto-correct and not to mention come with some very cool wicked themes. With all that, it's no surprise that a lot of people type faster on a phone than on an actual computer. Just for the record, my personal favorite keyboard is Swift Key.
Google Drive
I cannot stress how much I love Google Drive. It is one of the most important things I have on the cloud. I store images, documents, projects, homework – everything. I usually do all the heavy stuff on my computer (like making PowerPoint presentations) but the fact that you can link Google Drive on your phone and your computer has some very handy quirks. You can take pictures and then save it on your Drive and later open it on your computer. You can write a document on your computer and then save it on your Drive and open it on your phone. This isn't the only app of its kind (there are others like One Drive) but it's my favorite because I am in love with Google. To get best out of Google Drive, you do have to download additional related apps like Google Docs and Google Slides but trust me it's all worth it.
The "Getting Things Done" Apps
Otherwise known as GTD apps, it's a subcategory of Productivity apps and they, well, help you get things done. It has everything from calendars to apps that merge your duplicate contacts into one. I didn't even know I needed things like those until I saw in the app store. There are PDF readers to apps that turn images into PDF (a brilliant feature – the one I use is Cam Scanner). There are apps to help you find jobs and also get the latest updates on stocks. I wouldn't be exaggerating when I say that apps cater to everything. I could ramble on and on about all the different kinds of apps but there are too many to list.


text:
Thursday, 18 December 2014
Cairn William and Pitfichie Hill - across the granite
Shortly after leaving Whitehills stone circle a mountain bike trail leaves the main forest track and swings up through the forest to emerge at a cairned top. The heathery ridge of Cairn William lies ahead across mixed terain of moor and some scattered stands of trees. Above the forest I was exposed to a very cold westerly wind and was glad I'd planned the walk to have it at my back. The bike trail is easily followed but was icy in parts, especially where it crossed granite slabs and boulders which were smeared with verglas-like hard ice.
The upper part of Cairn William is a dome of granite planed smooth by the elements. It gives good walking......
...if the ice is avoided! The hill is traversed by a bike trail which links granite slabs, minimising any erosion.
The summit is easily reached and has a nice view across to Millstone Hill and the Mither Tap of Bennachie. At 448 metres/1470 feet Cairn William is a diminutive hill but is a "Marilyn", having an all round drop of over 150 metres.
The view to the east takes in a wide sweep of the Garioch (pronounced locally as "geerie"), the rich farmland around the River Don. In the foreground and across a shallow dip is Pitfichie Hill, really an outlier of Cairn William.
The view on the descent from Cairn William towards Pitfichie Hill is really fine. Bennachie dominates, as it does from so many places in Aberdeenshire despite being a relatively small hill. A beautifully wooded stretch of the River Don snakes bethween the hills, part of the wood near the foot of Pitfichie Hill is named Paradise Wood for good reason.
Little effort is needed to reach the summit of Pitfichie Hill which is 379 metres/1243 feet high. In mid-December the days are short and although it was quite early in the afternoon the sun was sinking quickly. There are a number of routes which can be taken to link up back to the Forest Enterprise car park, the one I chose using minor roads would be the longest in distance but would avoid the icy forest tracks and so actually probably be quicker. I made the steep descent down to the road at Pitfichie.....
....passing the pretty Pitfichie Castle on my way. Originally built in the 14th century, Pitfichie was a ruin by the 1960's but has been restored and is once again a private residence.
The walk by the route I took is about 17 kilometres, the going is good for almost all the way with just an occasional muddy stretch. The paths and trails are primarily mountain bike tracks and if walking it's wise to keep an ear out for cyclists who can fairly fly the trails.
Cairn William and the surrounding area are situated awkwardly on the deges of Ordnance Survey 1:50K Landranger sheets 37 and 38, and also on the edge of OS Pathfinder sheet 405. Usefully, Forest Enterprise have a map of the mountain bike trails. Perhaps the most useful overview is to take a picture of the trail information board at the car park - there was a leaflet published by Forest enterprise and although it seems to no longer be available, there are copies online (as here). The route I took used the white trail to post number 3 before angling up to join the red route at post 16 and working down eventually to post 11and taking the road back to the start.
Subscribe to: Post Comments (Atom)


text:
Vuru.com Helps You Get Healthy FAST with Vitamins Delivered to YOUR HOME!!Fashiontribes Beauty Buzz PODCAST and BLOG!!
! We don't always have time to eat right and no one wants to carry around a shopping bag full of bottles of vitamins, minerals and supplements. VURU.com makes it super-easy to take just the supplements you want or need in easy once a day packets that you order ONLINE plus can arrange for automatic shipments once a month! Being healthy is as easy and slick as clicking a mouse courtesy of Vuru.com
Here's the easy way around it– and I did it — and Lawd knows if I can, you can do this too because it's that easy. Vuru.com is a great place to find the highest quality vitamins and supplements in site where you can "cherry pick" your own personal "formula" of what want/need to take or you can choose from some of the standardized packages that they already have assembled.
What's cool is that 1) they give you all the 411 on what the supplement/vitamin is and what it does for the body and 2) it gives you the option of selecting the amount you want or need to take on a daily basis.
Check out the podcast with VURU.COM founder, Grant Kornman to get the scoop on this great way of getting–and staying–healthy with Vuru.com Vitamins and Supplements.
With all these cool supplements, you are presented with a virtual shopping experience a la grocery shopping on the web. Just fill you basket (or packets) and get what you want and need and voila, have it shipped to you monthly and you get the montly bill on your CC. Want to save a bit more money and still get GREAT supplements? Buy larger quantities and thus save some dinero and don't order quite as often.
Sent to you in 4 pouches of 7 packets each, you get a full month's supply (or whatever you choose to order) of supplements and vitamins that will help you get healthy and stay healthy. With all the running around that you do– working hard and playing equally hard, you need to have good nutrition to keep up with the game (or kids if you have them!)
Make sure you hit the website (www.vuru.com ) and order a month's supply of these babies, just to check out the amazing service. I found so many things I wanted to try in supplement land. It's definitely customizable and as you listen to Grant talk about how easy this is to get exactly what you need, you will find this a pretty slick– and fun- way of getting healthy.
If you try Vuru.com, please let me know what you thought!!
See you at the Vuru.com!!


text:
President Barack Obama Calls For Unity After Brussels Attack
President Barack Obama spoke from Havana, Cuba, where he is on a historic visit restoring relations with the country, on the morning of March 22.
At the beginning of his remarks, he took a moment to speak about the attacks in Brussels, Belgium that occurred earlier in the day. Two explosions happened at the Brussels international airport, and one happened in a metro station near the European Union.
The president said the United States stands in solidarity with Belgium and will do what is necessary to help.
Obama said these attacks are a reminder we need to stand together to defeat violence.
He stated,
The world must unite. We must be together, regardless of nationality or race or faith, in fighting against the scourge of terrorism.
As of Tuesday morning, CNN reports 34 people were killed and 170 were injured in the attacks, which happened several days after Salah Abdeslam, the suspected organizer of last fall's attacks in Paris, was captured in Belgium.


text:
I will be a guest teacher in a few local 200 and 300 hour YTT programs coming up in 2019. Please email me for more information regarding topics, times and programs I am involved with.
I also love to travel and visit new places. Here is a sampling my topics of study workshops. Please contact me privately for more information and availability.


text:
Two years ago I entered the world of 3D-printing, what started as an experiment evolved into something that consumes multiple hours of my time, almost every week. Is 3D-printing really the future and will it change our lives? In this post I will try to explain how 3D-printing integrated itself in my life and how I think it will take over all of our lives in the near future.
Some background
First of all, 3D-printing isn't new! It already existed in the late nineteen hundreds but the real breakthrough was back in 2000 at MIT. They developed it as a form of rapid prototyping, later on they passed their licenses on to six different companies, who were to develop it further. In 2005 the 3D market really exploded with the arrival of RepRap, a company that sells affordable 3D-printers for home usage. The best thing about these printers is that they can self-replicate, meaning that if you know someone with a 3D-printer you would only have to buy the hardware, the rest could be printed! From this moment on 3D-printing became part of many people's lives and more and more companies started focusing on developing 3D-printers.
My first steps
As mentioned before my 3D-printing story started about two years ago. I bought myself a RepRap Ormerod Pro, this was a kit so I had to put it together myself. After about two days my printer was ready for testing. This is when the frustration started, I tried over and over again but the printer just wouldn't print. My disappointment was huge, but I knew before I bought my printer that 3D-printing was for tinkerers and that you would have to try lots of things to get it working. Back then 3D-printing was something for "computer geeks" only. If you weren't prepared to put your time into it and just wanted a printer that worked out of the box, you shouldn't have bought a printer. Nowadays this kind of printers also exists, e.g. Ultimaker. After a few weeks I finally got my printer working, it wasn't perfect (yet) but it worked. My biggest frustration was warping, the plastic cooled to quickly which made the corners of my prints lift up. Especially with larger prints it was difficult to print a nice flat bottom for the model. This was fixed later on by putting a new (higher temperature) thermostat in my printer and remeasuring and straightening the angles of my axes.
After I got my printer fully operational it was time to print some awesome stuff. So I went online, searched some models and stumbled on a site called thingiverse. This is an awesome site where you can find almost every model you can imagine. The models are free to download for everyone, so another plus for thingiverse. I think this site has great potential for the future as 3D-printing will get more integrated in our lives. For example if you lose or break the battery cover of your remote control, you could just search the site using your model number, download the right file and print a new cover. It's really as easy as that!
3D Hubs
Off course a future in which everybody owns a 3D-printer is far from near, so what to do in the in the meantime? For this particular problem exists another great site called 3D Hubs. 3D-hubs is a site where owners of a 3D-printer can register their printer and make some money with it. You can search the site for a hub nearby, upload the file you'd like to be printed and you'll be able to print your file at an attractive price! To get your print you can choose between delivery or pick up. Sounds like a good deal doesn't it? Well it is a good deal, everyone wins! Owners can make a little money with their printers, and people who don't own a printer can print files at a bargain price. Students even get an extra discount which makes 3D-Hubs even more attractive! You can find my hub and calculate prices just by clicking the red button below.
So is 3D-printing really the future? In my opinion it is. First of all it will be better for the environment. Instead of shipping replacement parts from large companies across the world and storing them in large warehouses, companies will be able to just place some printers send their replacement parts over the internet and print them at location. Also 3D-prints can easily be recycled, when a print is no longer needed or broken you can just shred it and use the material for a new print. Secondly 3D-printing will make our lives way easier. If you search sites like thingiverse you'll stumble on some great things that solve live problems. It also works like a community, if you need a file for something and someone already made it then you can just download it and print it. But if there isn't a model that solves your problem yet, you can design a model yourself and upload it so others can benefit from your work as you benefit from theirs. The use of 3D-printing is becoming more and more popular with the arrival of new printers that work immediately out of the box, like for example the Ultimaker extended 2+ that was presented today at CES2016. This way 3D-printing finds it way to people who aren't computer geniuses and more and more people take up printing. So 3D-printing is the future? Yes I think so, but I also think so that it won't be for tomorrow. It might still take multiple years before 3D-printing gets perfected, cheaper and easier. Till that day, 3D-printing will probably remain something related to computer nerds and maybe even magic for some people. If you would like to see some of my prints from the past two years I would like to refer you to my instagram account as I often post my prints there!


text:
India opens new reprocessing plant
Nuclear scientists and engineers were called 'nation builders' by prime minister Manmohan Singh as he inaugurated India's latest reprocessing plant.
|Singh opens the Power Reactor Fuel
Reprocessing Plant-2
The facility at Tarapur will break down highly radioactive used nuclear fuel to extract uranium and plutonium for reuse in fast neutron reactors.
"We have come a long way since the first reprocessing of spent fuel in India in 1964 at Trombay," said Singh at yesterday's ceremony, "The recycling and optimal utilization of uranium is essential to meet our current and future energy security needs."
He went on to congratulate all those "who have played a role in this important landmark and who have contributed to the development of our capabilities in atomic energy. In their own way, each one of our scientists and engineers engaged in this very important national project are nation builders."
There are already several reprocessing plants in India – all operated by the Bhabha Atomic Research Centre – at Tarapur, Trombay and Kalpakkam. Small plants at each site were supplemented in 1998 by a new one of 100 tonnes per year at Kalpakkam, and this is now being extended to so that it may handle carbide fuel from the Fast Breeder Test Reactor.
The new plant inaugurated yesterday at Tarapur also has a capacity of 100 tonnes per year, and another entirely new facility is under construction at Kalpakkam.
Experts at the International Atomic Energy Agency told World Nuclear News that this second reprocessing plant at Tarapur is not among the facilities covered by the early 'type 66′ safeguards agreement or the more comprehensive India-specific safeguards regime agreed last year.
India's long-term nuclear power plans have been for a three-stage program which should enable it to eventually utilise its large reserves of thorium as reactor fuel. Besides importing technology and fuel from abroad, the country is still dedicated to using natural uranium in heavy-water reactors followed by plutonium-fuelled fast neutron reactors that would breed the thorium isotopes required for an ultimate fleet of advanced heavy water reactors. Key to all this is advanced capabilities in reprocessing used nuclear fuels to separate true wastes from materials that will be fuels for other reactors.


text:
Get Creative With the National Gallery's Writing Salon Series
If finishing that book you've been working on for the past few years is at the top of your list of 2016 resolutions, the National Gallery of Art in Northwest is here to help.
The NGA is hosting a series of writing salons at the museum, featuring a monthly theme and discussions designed to help participants tap into the museum's permanent collection to push their own creativity to the next level.
[ Related: Here's Where to Catch Freer Gallery Events During Renovation ]
With the quiet setting, comfy couches and world-class artwork, the NGA is the perfect place to spend a few hours with your story. The writing salon program adds another layer of inspiration, with talks and discussions, as well as guidance from local writers and poets on how to learn cross-medium lessons from the museum's collection.
The program kicked off in November with a workshop on setting. Using a Hudson River School landscape to illustrate the place of setting in a story, registration filled soon after opening.
[ Search: Find Apartments for Rent in Northwest ]
This month the second workshop will focus on character, using Picasso's works to explore creating complexity. The third is scheduled for April with multilayered narrative and 17th-century Dutch genre painting as the theme.
Each workshop is offered three times over the course of one weekend of the month. Sessions are held Fridays, from 10:30 a.m. to 1 p.m., and Saturdays and Sundays, from 1 p.m. to 3:30 p.m.
Although the workshops are free and designed for all levels of writing experience, pre-registration is required due to limited space. Given the popularity of the first session, a waitlist is available for those unable to register due to capacity.
[ Related: Restaurant Week Is Your Chance to Dig Into D.C.'s Best Food ]
The writing salon series is just one of several programming options for adults looking to learn more about art and the museum. Gallery talks and lecture series are held throughout the year as well as a drawing salon series for artists.
The Food for Thought series is another fun way to learn about art history, featuring lunchtime talks on exhibits throughout the year.
For more information on all NGA programming, visit the museum website.
Find your next apartment in the area with Apartment Showcase.


text:
As a married woman is it a good idea to hire a good looking female Househelp?
If your husband sleeps with the help is it your fault or can we blame him for being untrustworthy?
Comment 1. If a husband is sleeping with a house help the house help is not the problem
Comment 2: A particular guy has been shagging his house help for years now.. Madam is busy playing madam role so she doesn't have eyes to see.. You know care givers turn to feel more important when they have something going with the boss but this one, No! She's ever faithful and loyal to her madam and the three are living happily ever after. I don't know them personally but I wish I could let the woman know paaa. According to the guy, he can't stop cos house help is too sweet..
Comment 3: Wow, I don't even know what to say. She probably knows and is overlooking it. There's no way you won't know. The signs are always there.
Comment 4: Some people too are not selective enough. You can't be hiring a househelp with hips bigger than yours, she's finer than you, or you know your husband likes breasts then you hire help with big breasts. Not to say that's the reason for it happening but just don't bring temptation into your home.
Comment 5: Not overlooking per say, but you know when you might see a stare for too long but you shrug it off. Or she'll see them touch while passing a fork to him, and is like no that's impossible. There are always signs. Later on when the truth comes out (always has a way of coming out) she'll kick herself because she saw it but shrugged it off
Comment 6: Also why do you need to be selective of your house helps looks be selective of your husbands and no need to worry about that
Comment 7: You have a point. But still. I can't have Kim Kardashian walking around here
Comment 8: As much as you may not like someone like Kim k for argument sake. If she's serving you food, caring for your children, attending to you while your wife is busy at work. Hmm .I agree cheating can happen anywhere but this one dieh you are asking for it. Why why why would you do that
Comment 9: Well my husband knows his life is over if he messes around. I'll probably blend his "mini me" into a smoothie and feed it to him and his ashawo side chick
You can also leave your comments below:


text:
Draft, Dodge and Dirt. Injury and Rumor Report 11/07/18
Posted by: grrrtygirl Nov 7, 2018 | 442 views | 0 comments
Wrestlers added to DropTheBelt.com:
Nikki Cross
Wrestlers signed to WWE this week:
Io Shirai reported to the Performance Center this week. She signed with WWE last month.
Here is the link for the full list of new wrestlers reporting to the Performance Center this week.
WWE Injury List
Triple H
Pectoral Injury - Unknown Return Date
Out of surgery, happy to report all is well. Thanks to excellent medical care of Dr. Dugas and his team and all the well wishes, messages, tweets, and texts I got over the weekend.— Triple H (@TripleH) November 6, 2018
Road to recovery starts... NOW. #GameTime pic.twitter.com/cfEmocnDxi
Zelina Vega
Possible Concussion - Unknown Return Date
Tye Dillinger
Hand Injury - Unknown Return Date
Alexa Bliss
Broken Nose (Unconfirmed)
Roman Reigns
Leukemia - Unknown Return Date
Kevin Owens
Double Knee Injury - Unknown Return Date
Torn Bicep - Expected Return in Early 2019
Sami Zayn
2 Torn Rotator Cuffs - Expected Return in Early 2019
Left Labrum Tear - Expected Return in Early 2019
Sin Cara
Knee Surgery - Unknown Return Date
There is rumor that Shane McMahon is going to turn heel before Survivor Series.
A Miz face turn is going around the rumor mill as well. I sure hope not. He is a great heel.
There could be a match at Survivor Series with 4 Horsewomen vs. 4 Horsewomen. This could be an interesting match if it happens.
It is being reported that Brock Lesnar has a new multi-year deal. Will let you know if this gets confirmed.


text:
The idea of Bob Dylan becoming the keeper of Frank Sinatra's flame would have seemed preposterous 50 years ago. Dylan was revolutionizing songwriting in a torrent of words back then, instantly making the classics sung by Sinatra another generation's music. Parents' music.
Yet after two releases delving into the songs primarily from the first half of the last century, Dylan doesn't just double down on the strategy. ''Triplicate'' is, as the name implies, a three-disc thematic set of similar material. Virtually all of the songs were once covered by Sinatra.
It seems like an odd direction for America's greatest living songwriter, fresh off a Nobel Prize. Dylan hasn't released a disc of self-penned material since 2012, and it's worth wondering if the well has run dry. Maybe the inscrutable Dylan just likes singing these songs and wants to keep them alive.
Singing is the last thing you'd expect to hear discussed on a Dylan disc, yet his voice is surprisingly supple, even lovely. He reaches for, and finds, notes that you wouldn't think possible. The songs are recorded in a hushed, intimate setting with spare backing from his longtime band, many resting on a bed of steel guitar. They deserve to be heard in a cabaret setting.
These are songs of missed opportunities and lost love that feel right coming from a 75-year-old man. ''We were young and didn't have a care,'' he sings in ''Once Upon a Time.'' "Where did it go?''
Songs like ''Stormy Weather,'' "September of My Years,'' "Stardust,'' and ''Sentimental Journey'' are familiar, but others will be new to fans weaned on rock 'n' roll.
As well performed as the material is, the slower tempos allow a sense of sameness to creep in. ''Triplicate'' is more of a historical document than a contemporary recording, and absent a curiosity about songwriting of this era, some tedium is inevitable.


text:
About Us
Mary Sue, Jeff and their two children are the family behind Mana Gardens. We are cooks, photographers, writers, artists, environmentalists, comedians, and, of course, farmers. Together we are committed to growing the tastiest and healthiest food for you that we can.
Mary Sue Stevens
Mary Sue brings her breadth of experience as an educator, artist, photographer, salsa-maker, farmer, promoter, and professional hugger to the Mana Gardens team. She may have been a town girl when Jeff asked her out on a first date at age fifteen, but she's never been afraid to dig in and get her hands dirty. Thanks to Mary Sue, practically nothing from the fields goes to waste at Mana Gardens. She transforms any "seconds" not shared in our CSA or sold at market into amazing pestos, salsas, chutneys and dried seasonings that make up our value added product line. Mary Sue's vision is behind all the photos of our farm and produce. Also be sure to have a look at Awakening a Landscape, her photography project documenting the healthy food landscape of our region.
Jeff Aldrich
Jeff spent his childhood on a family dairy farm in Buffalo before attending college and spending many years as a software developer. He has had his own software consulting company and served as co-founder and CTO of a farm-to-table startup, but has always liked to spend time with his hands in the soil growing healthy food. In 2015 he committed to spending less time at a desk and more time outside growing vegetables and that dream became Mana Gardens. He has over ten years of experience producing vegetables using organic and sustainable practices. He is a member of the Crow River Food Council and the Crow River Chapter of the Sustainable Farming Association of Minnesota.


text:
Pumpkin Gingersnap Ice Cream
Ingredients6 h 15 m servings 552
- Adjust
- Metric
Directions{{model.addEditText}} Print
- Beat heavy whipping cream, vanilla extract, cinnamon and ginger in large bowl on medium speed with electric mixer until stiff peaks form.
- Combine pumpkin and sweetened condensed milk. Fold in pumpkin mixture and gingersnap cookies into whipped cream mixture.
- Pour into 9 x 5-inch loaf pan or other 2-quart container; cover. Freeze 6 hours or until firm.
Nutrition Facts
Per Serving: 552 calories; 31.2 36.8 4.6 99 250 Full nutrition
Explore more
ReviewsRead all reviews 8
I didn't actually try this recipe but this is a difficult recipe to get right and these instructions aren't detailed enough. If you decide to try this recipe, there are a couple things you need ...
Omg, this recipe is beyond amazing!! A close friend of mine requested that I make her some pumpkin ice cream (since my husband got me an ice cream maker for Christmas). I was a little nervous by...
I made this recipe for thanksgiving and it was a hit! The yummy Pumpkin ice cream was delicious and then you would get a part of a gingersnap and your mouth would just warm like magic. Also ev...
Made this and it was a huge hit. I cut back a bit on the sweetened condensed milk (didn't use the full can) - because other ice creams I've made using this method have come out too sweet for my...
It tasted exactly like pumpkin pie! It was delicious and very simple to make. My only problem, the reason I did not rate this recipe 5/5, is that the texture is grainy. I will make this again th...
Love the flavor. Not too sweet. It is more like a frozen mousse. Not a bad thing. But different. Light and easy to make.
I just whisked all of the ingredients then froze it in an ice cream machine. It tastes very similar to pumpkin pie filling.
Great! Made recipe as directed except finely crushing cookie s and adding a bit more sugar. Huge hit for my foodie friends.


text:
Emily Paulson '93
inducted 2012
Emily Paulson's concern for the needy was born as a teenager in teacher Len Long's Leadership class at North Central. As a class project, she spearheaded the largest food and clothing drive in the school's history. After graduation, she continued working on service projects while earning an education degree at Gonzaga University.
In 2008, Paulson became Coordinator of Gonzaga University's "Campus Kitchen" program. She and her student leadership team provided weekly dinners for chronically homeless men and women in Spokane. When the program went nationwide under the name "The Campus Kitchens Project," Emily became its first national Program Manager, overseeing affiliate programs at 31 colleges, universities, and high schools across the country.
A member of the Spokane Homeless Coalition, Paulson received the "Peirone Philanthropy Award" from The Inlander magazine in 2010 for her work with Gonzaga's "Campus Kitchen" and other charitable food projects. In addition to distributing Gonzaga food services' excess food to the needy, Paulson and her team collected donated food from local businesses and solicited donations from the public.
"To get people in a better place," explained Paulson, her weekly dinners for the homeless also feature outreach workers from Spokane Mental Health, the Community Health (CHAS) Clinic, the Salvation Army, and Gonzaga nursing students. "Having enough food to eat is an immediate need," Paulson explains, "but the importance of community feeds your soul."


text:
Here are some really terrific items: A vintage Early American style mailbox in its original gift box… A mint-in-box 1964 rooster cupola…. a pair of Lilly Pulitzer collapsible suitcases…and a large, gorgeous set of pink enamel Woodard patio furniture for the tony set.
Heh, my parents had those avocado bathtub anti-slip flowers until about 5 years ago. Naturally, they complimented the avocado tub and sinks. Sadly, the matching toilet is long gone.
Man, those suitcases are far out.
Oh I'm so in love with the pink patio furniture!