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bronchitis cough suppressant - Acute Bronchitis Treatment
Acute Bronchitis Treatment
To treat a case of acute
, one must take some steps in reducing the bronchitis symptoms. This is not a difficult task, especially if you are a healthy person, your only problem being bronchitis. Antibiotics are not one of the medication that work in case of
. Furthermore, if there is already a problem with your lungs, or with your heart, the
treatment will be a little more agressive.
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Sometimes people think that if the doctor prescribe them a lot of medication they'll be cured, but this is not a rule. In acute
it is not necessary to prescribe a lot of medication, it is just important to understand the cause of the disease.
If you're interest in and natural cures is based on obtaining the best care for you or your child, it's important to realize that in cases involving bronchial infection, a medical doctor IS the best care. Share with your doctor your desire to limit the use of prescribed medications and he will work with you and suggest alternatives that you can try for the relief of some symptoms.
- antibiotics are only used in cases of
where there is the risk of complications; For more resources about bronchitis or especially about chronic bronchitis please visit http://www.bronchitis-guide.com/chronic-
If you keep taking antibiotics for Bronchitis you find that after awhile they become less affective. In normal medical practice you don't have much option as that hacking cough tries to remove the infected phlegm that the infection causes.
These are some of the things that need to be made at home in order to heal from
. However, if your doctor considers that in your
case, there is the need for medication, these may often include the following:
- beta agonists, which can dialate your airways, thus realiving the bronchitis symptom, coughing; but the bad thing about this
medication is that it may have some side effects, which include tremor or shaking;
Homeopathic medicine was founded in the late 18th century and is based on using diluted substances from various animals' minerals and plans. The remedies are designed to match different symptoms of illnesses to encourage the body's natural healing process. The idea of like cures like is a basic premise of homeopathy.
In the history of medicine there are a lot of doctors who prescribed antibiotics for the patients with
acute bronchitis
and there was no beneficial result for them. Patients waited to be cured , but their condition was even worsen. But there are also some situations when the patients are looking for the doctor to prescribe antibiotics and when they receive a prescription without antibiotics they don't trust the doctor anymore. So it is very good for the doctor to inform the patients about all the aspects of the treatment and to make them to understand that antibiotics are not always the best choice.
While it may be argued that homeopathy may have its place, the treatment of
is not such a situation. The reason is that
, if left on its own may develop into pneumonia.
- because acute
is an infection, there is a lot of energy used by your body to fight against
; so in this period you should get a lot of rest and give your body a chance to recuperate and develop the necessary strength to fight
Homeopathy is the treatment of disease by consuming natural materials that are claimed to simulate the symptoms of the disease. The natural products are diluted in water and so the claimed effective ingredient can be given in extremely small amounts. The efficacy of this type of treatment is rejected by most medical experts today.
Homeopathic remedies are claimed by many to be better than medical science if only through their claim of being Natural. Take for example homeopathy.
Some people are unlucky enough to keep catching the
infection and will end up at the Doctors time and time again every year. Paying for prescription like this can put a strain on your budget, yet there is a natural
treatment available you can use safely at home.
If you are a smoker you are a prime target to get an infection and by using this natural cure you will find that you no longer need those antibiotics from your Doctor.
As it happens the new bronchitis treatment worked, and since that day thousands of people have tried this new cure and the testimonials are sound proof that it works.
A wrong prescription of antibiotics treatment can have a lot of negative consequences. First of all antibiotics are expensive and they may cause adverse side effects such as abdominal pain, diarrhea and rash. All this may require further treatment. If the administration of antibiotics lasts for a long period, they can induce resistance and the treatment against other infections becomes useful.
There are two types of
that one can have: acute bronchitis and chronic
. The acute bronchitis case is more easy to treat. Most of all the acute bronchitis cases go away in about two to three weeks. There is no special treatment necessary in cases of acute
, in almost all cases of bronchitis home treatment being the only one that is needed. This home treatment against bronchitis includes:
For more resources about bronchitis or especially about
symptoms please visit http://www.
About the Author: Mick Hince writes articles on Medical and Alternative mecical health. For more information on Bronchitis or any other medical problem please go to the following website.
It is usual for some doctors to prescribe antibiotics in some diseases even if they aren't necessary. Antibiotics have been prescribed for years in
acute Bronchitis
too, but they are not a solution for this disease.
About the Author:
For more resources about
or especially about chronic
please visit http://www.
Usually the agents that produce Bronchitis are viruses, bacteria or fungi so this is one of the causes why this disease doesn't respond to the treatment with antibiotics. There are also medicine articles and books which doesn't support the prescription of antibiotics in Bronchitis.
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- if you have a case of acute
, the best thing to do is avoid alcohol and caffeine; these products may case the loose of fluid in your body;
Because one of the symptoms characteristic for Bronchitis is cough, doctors prescribes anti-tusives. This must be a good choice, but studies and patient's reaction showed very little effect.
If your like me and truly believe that Alternative medicine is in a lot of cases better than some of the drugs we are given from the Doctors you find that this one comes highly recommended.
Please note that I am not a Doctor or am I in any way qualified to give opinion in medical matters, and that I only write on what I call common sense and that the patient should make their own mind up with regard to these things. (If you've ever had side affects from drugs prescribed to you I think you will understand what I mean.)
Each time he caught bronchitis he would try out his new
bronchitis treatment
on himself until the point he told several of his friends about his new bronchitis cure. At first they laughed at him but agreed to try his new cure next time they became infected as they were also prone to constant attacks themselves.
Bronchitis is caused by the inflammation of the bronchi of the lungs as a result of influenza or a cold and it is characterized by a persistent and frustrating cough.This occurs especially in winter because of the cold air, or even by breathing a polluted atmosphere air or by smoking.
There are two kinds of Bronchitis regarding the agent that caused them. We can speak about a
caused by viruses and which doesn't respond to the antibiotics treatment, and a Bronchitis caused by bacteria, such as whooping cough which respond to the antibiotic therapy. The treatment is not for a very long time, it lasts for five to ten days.
This isn't to suggest that all home cures are of no value. Many such as hot tea and lemon can work wonders in calming a hacking cough. Medicated warm mist vaporizers can loosen congestion an aid in breathing. Neither of these home remedies however can take the place of an appropriate antibiotic treatment.
Medical doctors today are in a battle with us as consumers to limit the use of antibiotics to only when necessary. It's the over-prescribing of these wonder drugs that has created many of the super bacteria that are now immune to the antibiotic medications. Still, wouldn't it be great to have some effective cough medicine to relieve your child's hacking cough in the middle of the night if the natural cures that working.
- to fight against fever and the body aches that you might have when suffering from acute
, you should take aspirin or ibuprofen; however, be careful not to give aspirin to any bronchitis patient that is under twenty years old;
Trying to treat bronchitis with natural cures or remedies may result in respiratory pneumonia. A medical doctor can quickly diagnose
and prescribe antibiotics when necessary to control the infection.
Obtaining the benefits of medical science makes you a wise and caring parent. This isn't to say that homeopathy is completely worthless. Many symptoms such as sinusitis and a bronchial cough can be treated without expensive pharmaceutical medications. Still, if you're a parent, wouldn't it be great to have some effective cough medicine to relieve your child's hacking cough in the middle of the night if the homeopathic remedy doesn't work?
The problem with the claims of many so called natural remedies is their effectiveness has never been verified by any scientific research. Consider homeopathy is based on an 18th century theory that apparently was NOT effective as the hospital wards were filled with patients that WERE cured with a little invention of modern medicine called antibiotics.
- realiving the cough, which is the trade mark for
; this is done by drinking a lot of fluids, taking cough drops and staying away from any irritants that may irritate your lungs even more if you have
acute bronchitis
; a person can also use in cases of
cough suppressants; these may help you from coughing; another way to go is using expectorants in cases of bronchitis, because these make coughing much easier and also bring up the mucus that is create when having
This is all down to one man who being a smoker kept getting
himself, and as he was a medical researcher he began to look into what caused bronchitis in the first place. What he found was that he needed to get rid of the germs that caused the infection in the first place, and using himself as a guinea pig he eventually came up with the answer.
A simple definition of
is inflammation of the bronchial tubes that send air into the lungs. There are two types of
, acute and chronic.
Acute bronchitis
is usually associated with a respiratory infection which itself can be either viral or bacterial.
- if you are a smoke and also suffer from
, the best thing to do is cut back on the daily number of cigarettes or even stop smoking, if possible;
To choose an appropriate treatment for a short -term Bronchitis it is recommended to be taken in consideration all the aspects of the disease. First of all it is a pulmonary disease and the lungs are vital organs and it is also very important to know the agent that produced the disease. The treatment strategies must be related to individuals, pathology and diagnosis.
About the Author:
Abigail Franks has done extensive research into Asthma,Allergies, and their triggers. Visit the Asthma site for more information on bronchitis and Asthma
Learn More about Natural Bronchitis Remedy
Contagious Nature Of Bronchitis - 16 Important Medical Facts
Bronchitis mans the chronic or acute soreness of our mucous membrane or the swelling in the tracheobronchial tree of our respiratory system. Tracheobronchial tree refers to the trachea or the windpipe & the bronchial tubes. This disease might be or might not be contagious, depending on some circumstances. Initially you must understand that there are two types of bronchitis - Chronic or the...
Information about Influenza treatment.
Influenza Influenza virus got first acknowledged in 1933. There are two main types of influenza: influenza A and influenza B. Influenza A usually causes a more severe illness than influenza B. So what is influenza exactly? Influenza or flu (as we know it commonly) is a respiratory illness associated with infection by influenza virus. Some of the symptoms of influenza are headache, fever,...
Diagnosing Bronchitis
There are many different methods when diagnosing bronchitis. The procedures used to diagnose bronchitis are painless and very simple. All you have to do is see a doctor if you think you have any bronchitis and he/ she will do some test to see if indeed you suffer from bronchitis. The doctor will probably listen to your chest if you think you have bronchitis. This is the most simple way to...
Lobelia Herb Treats Respiratory Problems and More
Lobelia (officially lobelia inflata), alias Indian tobacco, was a common herb prescribed by early North American doctors. Its main use was in healing respiratory ailments, such as asthma, bronchitis, pneumonia, and coughs. The plant stem, which has only a few branches, is smooth above while the lower part is rough and hairy. The lower leaves, which are about two inches in length, have stalks,...
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A Reminder To Live On Purpose/
Over the past few years, I've undergone a very intentional journey of personal growth. I've being guided to a new city and a different job. I made the decision to step away from several life distractions that are considered socially acceptable (if not required). I've been reminded to be patient with situations and people when I most want to intervene and resolve. I've spent a lot (A LOT) of very vulnerable time learning about myself. I've consumed more books, lectures, and podcasts than I'd thought possible. As a result, I've become a more confident, resilient, bright, and happy version of myself.
The path here hasn't been easy. At 32, I've become hyper-aware that I'm on the road less traveled. While this path has ultimately proven to be extremely fulfilling in a very short time; I sometimes feel lonely, confused, misunderstood, and judged. I've struggled to articulate why I feel so certain that everything is unfolding as it should and that I'm exactly where I need to be. I've butted heads with others who are determined that life can't be as happy and aligned as I describe. In these moments, I ask for guidance and reassurance. This evening, the guidance came at the end of a long conference call as the host read an excerpt from Rebecca Campbell's Light is the New Black. As she read it, my eyes filled with tears; it spoke to me deeply and articulated so clearly what I feel and believe. When I returned home, I pulled my own copy Light is the New Black off my shelf, opening to where my bookmark had been left some months ago...this passage was on the next page; just waiting to be read. I hope you read it and that it serves you as well:
I believe that you came into this life with a deep inner knowing of what you were here to do and an inner guidance system to make it happen.
I'm not talking a carefully laid out path which comes with an instruction manual, rather an unshakable deep seeded knowing that you're here for a reason, there is serious work to do and the universe will support you in doing it.
I believe until you answer this calling you will always feel like there is something missing and something you have forgotten. No matter what you use to numb it out, it will be there. The only way to stop the calling is to answer it.
I believe that your message is so deeply engrained in you that sometimes it's hard to realise that everyone doesn't think like you. They don't.
I believe you chose your parents. No matter how hard or soft, rich or poor, light or dark, old or young, present or not, kind or troubled – you chose them. And with this simple selection you were put in exactly the right place and given exactly what you need to inspire you to rise up, up into yourself. To take your position.
I believe that your tragedies, your losses, your sorrows, your hurt happened for you not to you. And I bless the thing that broke you down and cracked you open because the world needs you open.
I believe that life lessons are less about getting it right and more about getting it wrong.
I believe that you are more on track than you feel, even if you don't feel it – especially if you don't feel it. For the further you get off track, the closer you actually are to abandoning the wrong one and leaping over to the right one.
I believe that you are closer than you think and more qualified in your message than you could ever fathom.
I believe that the things that you are here to teach are the very things that you most need to learn, and that the best teachers are the ones that struggle the most because when they get it they get it with a triple smack down.
I believe that you are surrounded by your own personal team of angels, guides and teachers both in this world and beyond that are so completely devoted to your growth that if you knew, you would not spend one more day worrying about things working out. And if you could see things from their viewpoint… each time you'd see a challenge, you would meet it with a cheer.
I believe in you. And us. And all of this.
And so it is.

subset: commoncrawl


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Memorial Day Weekend BBQEvents
Join us to celebrate the start of Memorial Day weekend by taking a break with a BBQ on the back deck with your coworking community!
Join us to celebrate the start of Memorial Day weekend by taking a break with a BBQ on the back deck with your coworking community!
From lead generation to CRM platform management, get the leads and backup you need to close the deal every time. Expertly manage your relationships with your vendors and customers.
Startup Poker 2.0 is the flagship event of Startup Haven, a community-driven organization dedicated to connecting tech entrepreneurs with information, opportunities and each other.
The 2nd event of the workshop series about Launching Successful Online Products. We'll be covering one of the most important topics – Best Developers and Where to Hire.
Whether you're bootstrapping or venture-backed, pre-funding or post-funding, pre-revenue or turning a profit, there are steps you need to take to stay on top of your finances, maintain compliance, and establish the foundation you'll need to scale.
Set your peak performance strategy. Close the gap between where you are and where you want to be.
Bring your favorite cookie and their recipe to share with your Satellite Community.
Get the most out of your developers so they build an app that works! Learn what type of developers you should hire, how to manage them, and what documents you should use to protect your code/product ownership.
We are conducting Peak Performance Strategy Session that will improve your sales and business! Tony Robbins' Peak Performance Strategist will be running a 60 minute session tailored to your needs at no cost.
Bring in your favorite pie to share with the Satellite community.


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Set of captivating scents of prestigious Jasmine Sambac in Body Perfume and romantic Rosa Damascena active herbal ingredient promoting profound regeneration of face and hair.
Skin type. All skin types.
Texture. Lightweight oil.
Body Perfume: 50ml | 1.7 fl. oz. bottles, Hair Serum: 30ml | 1.0 fl. oz., Regenerating Beauty Oil: 15ml | 0.5 fl. oz.
Key Active Ingredients
Pomegranate Seed Oil. Very intensive antioxidant and anti-inflammatory effects, stimulation of keratinocyte divisions and thickens epidermis.
Jojoba Oil. Rich in vitamin E, phytosterols, fatty acids and squalane. High biological compatibility with the skin, quick absorption and perfect moisturiser.
Coconut Oil. The best skin care agent, predominantly composed of saturated fatty acids mostly lauric and myristic acids responsible for its antioxidant and anti-ageing properties.
Marula Oil. A youth elixir. Strong regenerating effects. Exceptional moisturising and cleansing properties. High content of essential fatty acids (linoleic acid and linolenic acids). Antioxidant ingredients, high biocompatibility with skin and is very quickly absorbed.
Tamanu Oil. Anti-inflammatory, bacteriostatic, tissue regeneration stimulation. Improvement of immunity and calming skin irritations. Oleic, linoleic and caffeic acids.
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Shea Butter/Oil. Non-saponifying fraction and regenerating triglycerides. Protection of the skin from adverse weather conditions and irritations. Strong antioxidant properties.
Available 24h
Free Worldwide Shipping
Visa, Mastercard, American Express, Paypal


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The Life Time range includes bedroom furniture dressed with unique armadillo printed leather, ultimately enhanced by exclusive "Giorgio Collection" bronzed brass handles and details. Dark Emperador Portuguese marble topped bedsides and chest of drawers, matched with the tallboy provides a full set of stunning bedroom furniture.
- Armadillo Printed Leather
- Dark Emperador Marble
- Bronze Brass Handles
- Lead Time: 6 weeks
Customise your product
in 1 step
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Tennis: Kingsford sinks West Iron County
IRON RIVER — Kingsford defeated West Iron County 5-2 in a battle of boys tennis unbeatens Wednesday at Nelson Field Courts.
"Competitive matches," said Kingsford Coach Mark Shanks, noting both teams were missing doubles starters. "I'm very happy with the way my doubles played."
Flivvers' Tyler Beauchamp and No. 1 doubles sub Preston Strong downed Brandon Henschel and Kevin Ballanger 6-4, 6-2. Kingsford also won at three and four doubles.
"Preston Strong played very well," Shanks said.
WIC No 2 doubles Seth Miatech and Steve Newby spilled Cameron Mulka and Nick Murvich 6-2, 6-3.
"Two doubles played well," Shanks said of the new team. "Those games were good and close."
In No. 1 singles, Kingsford's Alek Shanks outlasted Neil Tomasoski 6-4, 4-6, 6-1.
Rain washed out the No. 3 singles third set between the Flivvers' Nick McCole and Caden Pellizzer. The match and third set are tied at 1-1, with a possible conclusion in a May 23 dual at Kingsford.
Kingsford (5-0-1) hosts Marquette today. West Iron County (4-1) joins Iron Mountain, Negaunee, Escanaba and Menominee in the Kingsford Invitational on Saturday.
Kingsford 5, West Iron County 2
SINGLES: 1. Alek Shanks, K, def. Neil Tomasoski 6-4, 4-6, 6-1; 2. Brett Hicks, K, def. James Swanson 6-1, 6-1; 3. Nick McCole, K, vs. Caden Pellizzer 6-2 K, 6-3 W, 1-1 Inc; 4. AJ Weisnicht, W, def. Mikhal Roell 6-1, 6-1.
DOUBLES: 1. Tyler Beauchamp-Preston Strong, K, def. Brandon Henschel-Kevin Ballanger 6-4, 6-2; 2. Seth Miatech-Steve Newby, W, def. Cameron Mulka-Nick Murvich 6-2, 6-3; 3. Ethan LaVarnway-Aden Johnston, K, def. Dante Thurston-Christian Benson 6-4, 6-2; 4. Reece Fortner-Ethan Fox, K, def. Dawson Rybicki-Tyler Upperstrom 6-2, 6-1.


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You are currently browsing the tag archive for the 'video' tag.
Check out this vintage Japanese toy. It is a wind-up bear that knits!
OK. I don't know about you, but when I want to learn a new knitting technique, I tend to teach myself. First I will try it from looking at a book, if that fails, I will look for a video. If that fails, then I will go to a LYS and consult with someone there. I usually sort it with the first and second step, but when trying to learn fair-isle or multi-colored knitting I could not find a good video. Why? Because I knit Continentally.
While I also know how to knit using the English method, I prefer Continental. All of the videos I was finding, showed either the English method or Continental on one hand and English on the other. I'm sorry, I am not looking to juggle… There had to be a better way.
I went to consult with someone who knew what they were doing, and while they knit English method, I realized I needed to keep the yarns separate on the same hand and went home to sort it out.
After I figured it out, I randomly decided to make a video demo on the fly (definately not rehearsed, hence the *proper* dialogue – mega eye roll) to help other people who might be looking to learn like I was.
Check it out – hopefully it will be helpful to someone out there! :]


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Sound Man
Sound Man
in film, the member of the camera crew in charge of sound production.
The sound man helps develop the director's script and select the actors (according to the quality of their voices and their diction). He prepares the sound arrangement; conducts test recordings; mixes synchronized recordings; records the sound track, music, and sound effects; and dubs the film.
In the radio, television, and record industry, the sound man records, reproduces, and edits the magnetic tapes made under the direction of the producer, makes recording copies, and repairs old recordings.


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While yesterday pondering what it's going to be like during next week's dawning of this century's Great Depression, I stumbled upon a Champions League footie match on ESPN2 featuring Manchester United and some team in horrid mustard yellow uniforms.
I now have a better idea of how our country's whole economic meltdown has come about.
AIG, thrown an $85 billion life preserver this week, actually thought it a swell idea to spend $100 million to have its initials on a sports uniform.
If you like this story, consider signing up for our email newsletters.
You have successfully signed up for your selected newsletter(s) - please keep an eye on your mailbox, we're movin' in!
Brilliant! -- Richie Whitt


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UK MPs warn against growing number of British jihadists
London, March 26: A committee of British lawmakers chaired by Indian-origin MP Keith Vaz has warned the government that it is not doing enough to prevent youngsters leaving the UK to join Islamic State extremists in Iraq and Syria.
The lawmakers' report argued that preventative work with communities, families and international partners is vital and needs to be a top priority for the UK Home Office.
Vaz, who is chairman of the House of Commons Home Affairs Select Committee, said, "The number of cases being brought to public attention should ring alarm bells.
This must be a relentless battle for hearts and minds, and without a strong counter-narrative we are in danger of failing to prevent even more departures. We are at the edge of a cliff."
The disappearance of three London schoolgirls -- Shamima Begum, Amira Abase, both 15, and Kadiza Sultana, 16 -- who are believed to have joined IS in Syria, raised questions as to who could have done more to prevent their departure.
After taking evidence from the police and the families of the three girls among others, Vaz said their case suffered from a "lack of immediate action".
He added: "Schools and the police must inform parents immediately, and work with them even if there is the smallest hint of radicalisation, or a close association with someone who is thought to have been radicalised."
However, a Scotland Yard spokesperson defended the speed of the police response to the schoolgirls' disappearance. He said the committee's criticism was "misleading", pointing to the evidence given by both UK and Turkish authorities of "rapid exchanges" between the two.
The committee's report said there needed to be an advice service which would be a less extreme step than calling the anti-terrorist hotline.
Many youngsters were leaving to Syria and Iraq to join the ISIS
The Association of Chief Police Officer's lead officer for the government's anti-terror strategy Prevent, Chief Constable Sir Peter Fahy, agreed that more needed to be done. However, he said the police "do not have the capacity" to routinely work with every school in the country.
"The police service will play its part but the prime responsibility for dissuading young people from getting involved in extremist activity has to lie with parents, families and carers," he said.
The committee also pointed to weaknesses in information sharing with airlines and other countries.
It said greater care needed to be taken at airport check-in desks when people were travelling to destinations of concern - namely Syria, Somalia, Iraq and Nigeria, as well as neighbouring countries, such as Turkey.


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The Swiss Historical Village & Museum presents the unique story of the founding of New Glarus in 1845 and traces the Swiss colony's growth into a dairy farming community that continues to keep alive its ethnic heritage.
The museum, in the heart of "America's Little Switzerland," is owned and operated by the New Glarus Historical Society, Inc. The society is a non-profit organization dedicated to the preservation of artifacts, records and family histories of the Swiss immigrants. The society is affiliated with the Wisconsin State Historical Society.
Each year, the Swiss Historical Village & Museum welcomes a wide range of school groups, history buffs, Swiss enthusiasts, charters, families and sightseers. We hope to see you soon!
With Special Thanks to the
New Glarus Historical Society
Board - Effective March 2019
Jim Hoesly, Co-Vice President
Larry Klassy, Co- Vice President
Erica Loeffelholz, Secretary
Doris Arn, Treasurer
Board Members
Mary Dibble
David Hustad
Larry Klassy
Jim Hoesly
Al John Lienhardt
Erica Loeffelholz
Denise Anton Wright


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Selected papers (see entire list here)
Neurogenin regulates effectors of migratory neuron cell behaviors in Ciona [Preprint]
Susanne Gibboney, Kwantae Kim, Florian Razy-Krajka, Wei Wang, and Alberto Stolfi (2019)
RNAseq was used to identify potential effectors of Bipolar Tain Neuron cell behaviors like delamination, migration, and polarization. We identified various such candidate genes downstream of the transcription factor Neurogenin, including a potential small G alpha protein subunit that might act as a molecular "switch" for BTN delamination. LINK
Neuron subtype-specific effector gene expression in the Motor Ganglion of Ciona [Preprint]
Susanne Gibboney, Kwantae Kim, Christopher J. Johnson, Jameson Orvis, Paula Martinez-Feduchi, Elijah K. Lowe, Sarthak Sharma, and Alberto Stolfi (2019)
Transcriptional profiles of two distinct Motor Ganglion neuron subtype (ddN vs. MGIN2) were compared, resulting in candidate effectors of MG neuron subtype-specific functional and morphological traits. Among these are intriguing intracellular and extracellular proteins that might be controlling the dynamic repolarization of ddNs as they extend their axons across the midline. LINK
A cis-regulatory change underlying the motor neuron-specific loss of terminal selector gene expression in immotile tunicate larvae [Preprint]
Elijah K. Lowe, Claudia Racioppi, Nadine Peyriéras, Filomena Ristoratore, Lionel Christiaen, Billie J. Swalla, and Alberto Stolfi (2019)
We identified a cis-regulatory change underlying the reduced expression of a key neuronal regulator, Collier/Olf/Ebf (COE) in the Motor Ganglion of tail-less, non-swimming larvae of Molgula occulta. The MG-specific reduction of Ebf expression in turn might underlie a loss of motor neuron differentiation, as a result of relaxed purifying selection. LINK
Regulation and evolution of muscle development in tunicates
Florian Razy-Krajka and Alberto Stolfi (2019)
In this review article, we summarize the current literature on muscle specification and differentiation in tunicates, covering all major tunicate classes and orders, including thaliaceans (salps, pyrosomes, and doliolids) and appendicularians. We discuss these findings in the context of tunicate and animal evolution in general. LINK
Single-cell transcriptome profiling of the Ciona larval brain
Sarthak Sharma, Wei Wang, and Alberto Stolfi (2019)
Single-cell RNAseq was used to identify specific subsets of cells isolated and selected from the brains of Ciona larvae, and to determine the unique gene expression profiles of each cell type. PDF
Developmental system drift in motor ganglion patterning between distantly related tunicates
Elijah K. Lowe and Alberto Stolfi (2018)
Here we demonstrate that the specification and final arrangement of the distinct neuronal subtypes of the tunicate spinal cord homolog, the Motor Ganglion, is deeply conserved between distantly related solitary tunicates, suggesting that this structure represents an ancient and highly adapted minimal central pattern generator for larval swimming. PDF
Evolutionary loss of melanogenesis in the tunicate Molgula occulta
Claudia Racioppi, Maria Carmen Valoroso, Ugo Coppola, Elijah K. Lowe, C. Titus Brown, Billie J. Swalla, Lionel Christiaen, Alberto Stolfi, and Filomena Ristoratore (2017)
We found that the tunicate Molgula occulta has lost the genes encoding crucial enzymes for melanin synthesis, perhaps because its tail-less larvae do not swim and have no need for pigmented light- and gravity-sensing organs. PDF
Evaluation and rational design of guide RNAs for efficient CRISPR/Cas9-mediated mutagenesis in Ciona
Shashank Gandhi, Maximilian Haeussler, Florian Razy-Krajka, Lionel Christiaen, and Alberto Stolfi (2017)
We developed a novel pipeline for rapid yet accurate design, synthesis, and evaluation of efficient sgRNAs for high-throughput, tissue-specific CRISPR/Cas9 knockouts in Ciona embryos. PDF
Migratory neuronal progenitors arise from the neural plate borders in tunicates
Alberto Stolfi, Kerrianne Ryan, Ian A. Meinertzhagen, and Lionel Christiaen (2015)
We show that a neuronal cell type in the larva of the tunicate Ciona, the bipolar tail neuron, shares a set of features with neural-crest-derived spinal ganglia neurons in vertebrates, hinting at the pre-vertebrate origins of the neural crest. PDF
Tissue-specific genome editing in Ciona embryos by CRISPR/Cas9
Alberto Stolfi, Shashank Gandhi, Farhana Salek, and Lionel Christiaen (2014)
We report the first use of CRISPR/Cas9 for tissue-specific genome editing in the tunicate Ciona. Using this technique to disrupt the Ebf gene in different cell lineages, we revealed that its function is required for specification motor ganglion neurons and atrial siphon muscles. PDF
Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians
Alberto Stolfi*, Elijah Lowe*, Claudia Racioppi, Filomena Ristoratore, C. Titus Brown, Billie J. Swalla, and Lionel Christiaen (2014) *equal contributions
Comparisons between the distantly related tunicates Molgula and Ciona reveal cryptic turnover
of regulatory mechanisms that underlie identical gene expression patterns. PDF
Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene
Paschalis Kratsios, Alberto Stolfi, Michael Levine, and Oliver Hobert (2012)
We show that UNC-3/Ebf is a terminal selector for cholinergic motor neuron differentiation whose function is conserved across phylogeny, from C. elegans to Ciona. PDF
Genetic and genomic toolbox of the chordate Ciona intestinalis
Alberto Stolfi and Lionel Christiaen (2012)
A review on the tools, techniques, and resources available to the Ciona geneticist, citing examples of studies that employed such strategies in the elucidation of gene function in Ciona: electroporation, transgenesis, genetic screens, and a preview of the emergence of genetic engineering platforms like CRISPR/Cas9. PDF
Neural tube patterning by Ephrin, FGF, and Notch signaling relays
Alberto Stolfi, Eileen Wagner, J. Matthew Taliaferro, Seemay Chou, and Michael Levine (2011)
We show that the Ciona Motor Ganglion is patterned by sequential Ephrin/FGF/MAPK and Delta/Notch signaling events that lead to localized expression of conserved homeodomain codes for the specification of distinct neuronal subtypes. PDF
Neuronal subtype specification in the spinal cord of a protovertebrate
Alberto Stolfi and Michael Levine (2011)
We used fluorescent reporter constructs to label and identify invariant but morphologically distinct moto- and interneuron subtypes in the Motor Ganglion of the Ciona larva. We also perturbed neuronal subtype specification in predictable ways by targeting specific transcription factors and signaling molecules. PDF
Early chordate origins of the vertebrate second heart field
Alberto Stolfi, T. Blair Gainous, John J. Young, Alessandro Mori, Michael Levine, and Lionel Christiaen (2010)
We found that heart progenitor cells of the simple chordate Ciona also generate precursors of the pharyngeal muscles. These precursors express Islet and Tbx1/10, evocative of the splanchnic mesoderm that produces the lower jaw muscles and Second Heart Field of vertebrates. We propose that the last common ancestor of tunicates and vertebrates possessed multipotent cardiopharyngeal muscle precursors, and that their reallocation might have contributed to the emergence of the SHF. PDF
Gene regulatory networks underlying the compartmentalization of the Ciona central nervous system
Kaoru S. Imai, Alberto Stolfi, Michael Levine, and Yutaka Satou (2009)
Here we document provisional gene regulatory networks operating in the developing central nervous system of Ciona, at single-cell resolution. This revealed a striking conservation in neural gene expression and patterning relative to vertebrates. More careful analysis revealed a role for FGF8 in patterning the Ciona hindbrain in a manner reminiscent of the midbrain/hindbrain boundary organizer in vertebrates. PDF


text: Idina Menzel is an American actress and singer. She rose to prominence when she originated the role of Maureen Johnson in the Broadway musical Rent, a role which she reprised for the 2005 feature film adaptation of the musical. She received a Tony Award nomination in 1996 for her performance in Rent. In 2004, she won the Tony Award for Best Actress in a Musical for originating the role of Elphaba in the Broadway musical Wicked. Menzel made her return to Broadway in the 2014 original musical If/Then, which earned her a nomination for the 2014 Tony Award for Best Actress in a Musical. She was then honored with the Breakthrough Artist award at the 2014 Billboard Women in Music awards ... more on Wikipedia


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can be expensive and unnecessary. Especially when considering that fact that basic care and residence repairs can keep you from having to pay these kinds of outlandish bills.
Keeping your refrigerator stocked, but not more than stocked actually helps it to keep optimum operating capability. Also, keeping the area underneath and round the fridge obvious will help it to continue working well. There should be no less than three ft . of very clear space close to your family fridge. Make sure that it is really not sitting up against the wall sometimes as this will keep the heat generated by the coils on the back from dispensing properly.
A refrigerator cools down the products on the inside by dispensing warm air to the outside setting surrounding it. If it could not release this excess hot air appropriately then your inside will not cool adequately. Dust and grime about the back coils and underneath can work as a blockage as well, which keeps it from having a well-balanced temperature. Trying to keep these things crystal clear is a simple in the home refrigerator maintenance that will last in the future whilst keeping the repairmen at bay. Checkout: visit our site for more details.
Also, keep a see on your heat gauge and thermostat. Once in a while it can be necessary to reset it. When your refrigerator begins to run warm this may be the reason. Also, should it be necessary to unplug your family fridge try to keep enough time to a minimum. Retaining it unplugged for an expanded amount of time can lead to some malfunctioning in certain factors.
If it is required for you to shift it, make sure that it is entirely empty, remains to be upright, which once you have it situated in the newest place you depart it standing up unplugged for a minimum of thirty minutes well before plugging it in and turning it on. Remember that it may take a lttle bit for it to attain optimum temperature once this has been moved and plugged in. Tend not to stock it until it has reached the proper temperature. When you fill it too soon not only will it improperly cool your groceries but it will not get to a balanced heat.
If you individual a fridge, as the largest percentage do, generating the care a priority can save you money and keeps your refrigerator lasting for quite some time. Fridge repairs regardless of whether done both at home and by professionals is area of the responsibility of any homeowner who owns one particular. If you know what to expect and how to protect against most problems you will have a very much smoother life time for your appliance.


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Geeksn0w_cli 1.0 beta for Mac
Download geeksn0w Mac version and jailbreak iPhone 4 running on iOS 7.0 -7.1.1
Here is the good news for iPhone 4 users which is geeksn0w team has successfully released geeksn0w Mac version few hours ago. Geeksnow is the best jailbreak tool for jailbreak iOS 7.1, iOS7.1.1 at the moment. Here is the good opportunity to jailbreak iOS7.1.1 with geeksn0w Mac jailbreak tool. But geeksn0w Mac only supports for iPhone 4 (A4 chip devices).
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Turning the tables: the Digest looks at You, the biofuels reader
Today, we look at a really, really important topic: You.
As a bioenergy reader, what influences your thinking, what kind of information are you searching for, how do you respond to messaging, and when, and how? Is media power becoming more diffuse, or more concentrated?
In the issues of Biofuels Digest, we almost invariably look at the trends relating to companies, products, processing technologies, or feedstocks. In today's Digest, we're going to flip that around and look at you – the bioenergy-based reader.
We get a lot of questions about how to reach you, influence your thinking, and attract your attention. Figuring out how to reach people with your own message is inevitably important in a sector that generates more than $80 billion in direct economic activity – and a lot more indirectly. And the data streams are getting far more sophisticated these days.
Today, in a spirit of community rather than with Big Brotherian ambitions — we look at you, the Digest reader.
Who are you? The Demographics
Turns out that the average Digest reader is male, affluent, super educated and middle-aged. 51% of internet users are women, but 63 percent of Digest readers are guys. 46% of internet users are aged 35-64, but 61% of Digest readers are. 20% of internet users earn more than $100,000, but 36% of Digest readers do. 14% of internet users have gone to grad school, while 29% of Digest readers have.
Where are you? Which countries?
On the web, 65% of Digest readers are in the US, though the publication is read in every country of the world (including the Vatican – giving hope that even the Popemobile may one day switch to biodiesel). Turns out though that Taiwan holds the record for the highest number of pages per visit, and the most time spent with an average page.
Other popular countries? Generally, countries where English is dominant or widely spoken, unsurprisingly. Canada, the UK, India, Australia. But There's a steady readership across the EU – among the top 10 countries are Germany, France and the Netherlands. Brazil also makes the top 10, while lots of Asian countries including China, Japan, Malaysia, Thailand and Singapore are found in the top 20.
Which states?
In the US, the top states are California, Texas, New York, Illinois and Massachusetts. Those last two are surprisingly avid readers – also the readership is heavy in Colorado, DC, Minnesota, and Iowa. However, Kentuckians read the most pages per visit and spend the most time per page.
Which cities?
The biggest cities, for readership, are New York, Washington, London, Houston and San Francisco. Top cities outside the US (besides London)? Singapore, Toronto,, Paris, Sydney and Bangalore. Biggest college town? Madison, Wisconsin, which checks in at #15 globally.
The most page views per reader? Jakarta, followed closely by Ottawa and Paris. The most time spent per page? Dallas, followed by South San Francisco. The shortest attention span, globally? Bethesda, followed by Minneapolis, Sydney, Melbourne, and San Diego.
How many Digest readers are there?
Depends on how you count. There are 67,000 monthly unique visitors on the web, we have 48,000 subscribers to a Digest newsletter, and about 16,000 followers in social media. All together? That's 130,000. One way of thinking about that is that there's bound to be duplication in there (so, the net number has to be be lower). Conversely, we've had 164,000 unique web visitors over the summer, so if you count it that way, the total heads north of 200,000.
What do you read?
What a broad mix. Digest readers accessed 19,575 different stories on the site this summer – suffice to say, you are highly driven by your own interests, rather than by the headlines.
But one thing is sure. You like stories about game-changers. Companies going to the next level, or out of business, or shaking themselves up. You like rankings too – the Hot 50, and rankings of people are perennial winners. Trend stories are fairly popular too. Marine biofuels, biobased intermediates, updates in the Advanced Biofuels Project Database – all of them attracted your attention.
Some of the top stories this summer? "How Joule may turn biofuels upside down", "advanced biofuels pioneer terrabon files for chapter 7 bankruptcy — one off or trend?", and "sapphire completes construction of the green crude farm – algae biofuels heads for the next level." Coskata's switch to natural gas, the Obama plan for advanced biofuels, the completion of Beta Renewables Crescentino project.
How far back will you go to read a story?
Interestingly, stories don't die on the Internet, unlike print, where yesterday's news is today's fish wrap. On the main Biofuels Digest site this summer, 18 percent of the stories you read were from 2010 and 2011 – and it takes roughly three months for a story to accumulate its total readership.
In the case of our most-read story of the summer, "How Joule may turn biofuels upside down" — only 25 percent of readers who eventually read the story did so on the first day the story broke. 42 percent had read it by the end of the week (July 13) and 60 percent by the end of the month. It wasn't until the end of August that the figure reached 79%, and 98% of all readers to date by September 30th. Meaning that nearly as many people read the story in its second month on the site as read it on day one.
When do you read?
Well, it's probably a self-fulfilling prophecy, since we release the Digest at 9AM ET, but the 9 o'clock hour is the big winner. For those of you trying to get a release into the marketplace, that's a great time to target to maximize readership. Bad news? After 5pm, of course, when readership dips sharply. But you get a longer read later in the day, too, as reading time peaks at over 4 minutes at 3AM.
Searching for information
We find this one fascinating. A look at what people search for in Google. Unsurprisingly, 45 percent of those searching the term "biofuels digest" over the last few days clicked through to the site, but we think it's fascinating that 42.5 percent of Google clicks on the search term"how did 9/11 change the world" found the Digest. Other terms where the Digest picks up a lot of overall web traffic – Range Fuels, bioisoprene, farnesene, Chemtex, Codexis Shell, algae biofuel india and biodiesel company.
This summer, the big search terms? Biofuels, Amyris, LS9, medco, codexis, Genomatica, and KiOR.
Social media
It's amazing that there isn't more cross-media clicking going on – Twitter users or Facebook mavens clicking through to websites, but it rarely happens. Just 2 percent of the Digest's traffic comes from social media. Who are the champs – Facebook, LinkedIn and Twitter, in that order. Interesting to us, since the Digest is hardly active at all on Facebook but distribute all of its content daily via Twitter.
The bottom line
Although we rarely spend our days gazing at the data streams, it's kind of Big Brotherish, when you think of how much data a popular website can accumulate on what influences people when they are accessing information.
One thing we note. There's an awful lot of discussion these days about the "democratization of the web", and how social media and citizen journalism are reshaping the landscape – that more and more voices are creating a "conversation" on the web. That may well be the future, but we are not seeing it in the data.
When 10-15 percent of all global Google searches on a single term such as "Codexis Shell", "Chemtex" or "Secretary of Agriculture 2012" are coming to a single website (which is, ahem, just a little less trafficked than the New York Times), it tells you that we are not necessarily living in an era where information is getting more diffuse. We can only imagine what kind of influence that Facebook, the Huffington Post and Google are accumulating. Media power may be getting more concentrated.
Category: Top Stories


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Recharging,reflecting and connecting
The holidays are great, they give you time out from your daily schedule, the activities that you do day in and day out often on automatic pilot. They give you the opportunity to stop and recharge. This is exactly what I managed to do this year in the lovely surroundings of Somerset with my family and dogs. I had the opportunity to read a book, catch up reading magazines I had bought last year, colour with my children, spend time with my husband, do a bit of yoga for myself and go for long walks in nature with my furry companions too. It was wonderful to stop and be absorbed in it all. I was able to forget about everything, the responsibilities, the day to day for a week. It was just what I needed. The trouble was when I returned. I am sure I am not alone. The wonder of the holiday quickly disappeared in piles of washing, being back at work, a house to keep in order and all that is involved in preparing for my kids going back to school. All too soon I was starting to feel overwhelmed again by it, I stopped getting on my own mat, taking time out to enjoy all that was around me. Then I took the kids swimming – they had been wanting to go for ages and for an afternoon I was completely present, completely connected and the peace from the holiday in Somerset returned. I had stopped again, was doing something that nurtured me.
When it all gets too much we need to take a moment to step back, to breathe, may be to step into our yoga mats and reconnect with now. Sometimes the hardest thing to do in midst of it all is to stop, to work out what is really important to you, what are you doing that is not nurturing your wellbeing and then make a changes.
In the midst of feeling overwhelmed this week I received the following article in an email to my inbox – it was like someone or something was trying to tell me something.
'Simplifying your Schedule' by Madisyn Taylor
So as you head into Autumn, prepare to get kids back to school, return from holiday and get back to work or simply have been feeling that it is all too much may be it is time to stop, take a good look at your lives and start nurturing the things that nuture yourself.
Recharge, review and reconnect
Enjoy the article too!
Karen x


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Day one, Monday 24 September 2018
Registration and coffee
Welcome and chairman's opening remarks
- Edward O'Rourke CEO & Partner - Ashtons Legal
Keynote plenary: Our firm's innovation/transformation journey
Three managing partners / CEOs will each present a fast-paced, TED-style presentation looking at their business model, the challenges and obstacles they faced, how they've made it work and how they are driving innovation and change in their firm. Followed by facilitated joint Q&A.
- Andy Raynor Chief Executive - Shakespeare Martineau
- Peter Lee CEO - Wavelength.law
Cross-sector case study: The people and skills challenges facing the future accountancy practice – and what mid-market legal can learn from our experience
All forward-thinking managing partners in professional services are wrestling with fundamental questions about people, skills and organisational culture. This has probably always been the case. But is arguably more important now than ever due to the way in which IT and technological advances are changing the professions. In the future, will the traditional skills of lawyers and accountants continue to be relevant? How can we make sure our firms can deliver value services that are supported by the strategic use of technology? What new skills and organisational structures will be needed to do this? After a career spent primarily in industry, Ian Carlson joined Old Mill in 2008 and was appointed Managing Director in 2015. He sees addressing these issues as his number one challenge, including:
- getting the right calibre of staff for the challenges we face now and in the near future
- how we can usetechnology to help develop our businesses so thattech and AI do more of the rote work, allowing staff to focus on being valued advisors
- making sure our firms have both the consultancy skills to provide value services and the technical skills to support strategic IT
Ian Carlson, Managing Director, Old Mill
Old Mill is an ICAEW top 40 ranked accountancy practice based in the West Country, with 4 offices, 300+ staff and a £20m turnover.
Keynote Speaker
- Ian Carlson Managing Director - Old Mill
Networking break
Facilitated round table discussions (A)
This series of hosted round table discussions (A1 – A9) will focus entirely on how other firms deal with the challenges you face. These interactive and informal discussions follow Chatham House rules – giving you the freedom to speak your mind. Small groups allow everyone to participate and each group feeds back, giving all attendees access to the knowledge pool. These brainstorming sessions will give insight into your peers' challenges and provide solutions to your own.
There will be two 40-minute sessions.
A1 Our journey from LLP to a corporate structure and what we learned (and are still learning) along the way
Vember Mortlock, Managing Director, Roythornes
A2 Performance measurement: Developing KPIs that look beyond billable hours
What gets measured gets done. But how can you measure the success of those with soft client-focused skills? How can you pin down the contribution of specific individuals in improving clients' experiences with your firm?
Alison Morley, Director of Sales & Innovation and former Managing Partner, Capsticks
A3 Remuneration strategies: How we persuaded equity partners to move to market-level salaries
Amanda Glover, Managing Partner, Baker Law
A4 Succession planning: what should you be doing now to make sure someone can replace you?
We'll look at:
- identifying a pipeline of potential candidates – who on earth would want to be a managing partner?
- what management experience do you need in your successor
- tips on coaching and mentoring your replacement
- what do you, the current managing partner, have to offer outside of the firm
- how can you prepare so that the decision to step down is made at the right time
Simon Holdsworth, Managing Partner, Thrings
A5 From client triage to data analytics to predictive modelling – how and why we built our own tech platform and what it's doing, and will do, for the firm
We couldn't find the on-boarding tech we wanted, so we built it ourselves. Then we realised that the client and in-house data we were collecting could identify the drivers of cost and case duration in family law, to the benefit of the firm and our clients. Now we are building an app that will model cost outcomes for clients before the first consultation. We'll talk about how we resourced this technical development in a small firm, our work with IBM Watson on data analytics, how we use the platform and our plans for commercialising it.
Alan Larkin, Director & Head of Innovation & Technology, Family Law Partners
A6 Data Science - the sexiest topic around?
We are very familiar with the value of data analytics but what about data science? Thorntons Law has employed a data scientist for over a year. Helen Archibald, COO, will describe how Thorntons has benefitted from this, speak about the insights of data science compared with the inquiry of data analytics, and share a live example which has applied machine learning. Helen will also explain how Thorntons recruited its data scientist first as a student through Data Labs, a collaboration between industry and universities in Scotland.
Helen Archibald, Chief Operating Officer, Thorntons
A8 Using RPA in mid-market legal - a case study
Edward O'Rourke, CEO & Partner, Ashtons Legal
A9 Business Development in the mid-market – how can we get lawyers to think like business people?
To complete, firms must increasingly act as a business. We will look at:
- Staff Incentives
- Training
- Networking and Speaking engagements
Denis Stevenson, Business Development Director, Rowlinsons Solicitors
- Alan Larkin Director & Head of Innovation and Technology - Family Law Partners
- Alison Morley Managing Partner - Capsticks
- Vember Mortlock Partner and Managing Director - Roythornes
- Denis Stevenson Business Development Director - Rowlinsons Solictors
Lunch and networking
Think Tank on the psychology of innovation and entrepreneurship: how you and your team can learn to innovate and keep up with the exponential pace of change
The pace of change in business has increased substantially, meaning that staying on top of it, and "at the top", is becoming increasingly difficult. But whilst many people and organisations recognise the need to become more innovative and entrepreneurial, very few have a clear strategy for it.
We will look at the latest evidence-based insights into increasing innovation and developing an innovative, entrepreneurial mindset. The workshop will provide in-depth understanding of the theoretical underpinnings of innovation, disruptive talent and entrepreneurial culture, and their measurement and management. The focus will be on using these tools to help you foster innovation.
Keynote Speaker
- Dr Gorkan Ahmetoglu Lecturer of I/O & Business Psychology, and Co-Founder - University College London, and Meta Profiling
Networking break
Facilitated round table discussions (B)
This series of hosted round table discussions (B1 – B8) will focus entirely on how other firms deal with the challenges you face. These interactive and informal discussions follow Chatham House rules – giving you the freedom to speak your mind. Small groups allow everyone to participate and each group feeds back, giving all attendees access to the knowledge pool. These brainstorming sessions will give insight into your peers' challenges and provide solutions to your own.
There will be two 40-minute sessions.
B1 Why we gave up trying to get lawyers to think like business people – and what we did instead
We'll look at how a mid-market firm brought in dedicated business managers for each line of business to work alongside partners in driving the business
Ed Fletcher, Chief Executive, Fletchers Solicitors
B2 No way out? Exit planning tips for a leadership change
- why you need an exit plan for the good of the business
- how do you know when it's the right time for a change of leadership?
- what does a successful exit plan look like and what's a reasonable time frame?
- what happens to the old managing partner when there's a new one?
Ian Morris, Chairman, EMW Law
B3 Closing the productivity gap
We've invested in technology but haven't seen the expected gains in productivity – why is the sales gap growing and how can we close it? We'll consider:
- why isn't fee-earner time feeding through to the bottom line?
- can we re-set priorities re non-chargeable time?
- chargeable hours – target or baseline?
Sarah Perry, Managing Partner, Wright Hassall
B4 Using AI in mid-market legal
As the technology becomes more mainstream, we'll look at applying AI and machine learning tools to law and challenge the assumption that AI isn't yet applicable to mid-market firms.
Peter Lee, CEO, Wavelength.law
B5 What has flexible working ever done for us?
Imagine our 8-year-old suffers a very serious orthopaedic injury on a Friday. Turns out that Friday is the day that the top local ortho surgeon works from home/doesn't work at all. What's our reaction? Can the hospital deliver a plan B that works? How will our law firm find that plan B for clients, as just saying no to flexible working is never going to work? How do we find that balance between clients who expect 24/7 and our personnel who want a life?
Dinesh Raja, Managing Partner, Bowling & Co Solicitors
B6 A practical discussion of data analytics case studies, delivering a competitive advantage to law firms
Robert Camp, Managing Partner, Stephens Scown
B7 Future-proofing the business with a more agile platform
Edward O'Rourke, CEO & Partner, Ashtons Legal
Networking break
Take a quick breather and grab a drink before joining us for the final engaging session of the day.
Alternative Views – Management v Equity Partners: who's in charge in mid-market law?
We'll re-convene for an informal and interactive session using the "Samoan Circle" format. Set up in the round, delegates will gather around a central circle to eavesdrop on a frank, facilitated, conversation which will initially be between four managing partners about the ownership and management challenges facing mid-market firms. Audience members can join in the discussion by entering the "inner discussion circle" and sitting down.
We'll start by addressing the questions that are keeping law firm leaders up at night:
- Is the LLP still a valid ownership model for mid-market firms?
- What can we do to get equity partners to engage with the business as leaders and owners?
- How can we focus the management team on driving the business forward, not just on keeping equity partners happy?
- How can we, as managing partners, motivate the management team to take the risks that come with changing to ownership structures?
The working principles of the Samoan Circle are:
- Only those in the inner circle may speak, until prompted to retire
- You can enter the inner circle at any time if you want to join the discussion
- You must finish your point and leave the inner circle when prompted by the facilitator
The bar is open, Sli.do awaits your questions / comments and we hope you'll join in the conversation.
Chairman's closing remarks and end of day one
- Edward O'Rourke CEO & Partner - Ashtons Legal
Drinks reception
Dinner and entertainment followed by overnight stay
Day two, Tuesday 25 September 2018
Registration for the Alternative Legal IT Conference and coffee
The Alternative Legal Management Summit will reconvene for day two and will merge with the first morning of the Alternative Legal IT Conference.
Chairman's welcome and opening remarks to both the Alternative Legal Management Summit and the Alternative Legal IT Conference
- Martyn Wells IT Director - Wright Hassall
Emerging technologies and professional services: what's out there, what it can do for you and what you should do about it
A specialist in strategy and innovation, with a particular focus on creative and innovative solutions for professional services, Nigel is one of Twitter's top 25 AI influencers and an inspirational speaker on the future of technology. He'll look at:
- what are the technology trends affecting professional services and how the professions are reacting
- what tech is on the horizon and how it will be used – to drive customer service, foster loyalty or enhance profitability
- how it's AI plus other technologies that will really be transformative: AI + VR/AR, AI + IoT, AI + blockchain
- a beginners' guide to quantum computing: what it is, why it matters and why you don't need to understand it to accept it and use it
- how mid-market law firms might better exploit the potential of technology now and in the future
Keynote Speaker
- Nigel Willson Global Strategist - Microsoft
How social engineering threatens your firm (and therefore your data, your clients' data, your reputation and your clients' reputations) and what you can do about it
Law firms, no matter what size, are repositories of valuable, confidential information and are therefore ideal targets for hackers seeking valuable data. As a result, it's increasingly common for clients of even mid-market firms to seek reassurance about how firms protect their data.
As an expert in social engineering – the human element in security – Jenny helps organisations protect themselves from attempts to steal data and personal information. Known for talking her way into high-security banks and even the Tower of London, Jenny uses her unique mix of skills as a shrewd behavioural scientist, master negotiator and actor to help you protect your firm, your employees and your clients from malicious attacks.
Keynote Speaker
- Jenny Radcliffe "People Hacker" and Behavioural Scientist
Your right to reply: Managing Partners & IT Directors have their say
Following two eye-opening keynotes examining the most serious threat (security) and the greatest challenge (the pace of technological change) facing mid-market firms today, a Managing Partner and an IT Director will join Nigel Willson and Jenny Radcliffe on stage to pose the questions that most IT Directors and Managing Partners will have for our speakers. We'll also take questions from the floor and via Sli.do.
- Jonathan Freedman Chief Technology Officer - Howard Kennedy
- Amanda Glover Managing Partner - BakerLaw
- Tony Williams Principal - Jomati Consultants
Networking break
The Alternative Legal Management / Legal IT Room 101: Changing partner behaviour to improve productivity
Managing partners and IT directors are closely aligned on the biggest problem facing their firms: the challenges of changing (equity) partner behaviour to improve productivity. But while it's easy to agree on the problem, it's much more difficult to find a workable solution to what appears to be intractable.
We'll give two managing partners and two IT directors each the chance to nominate what they see as the number one barrier to changing partner behaviour and improving productivity in the firm – and each will provide a suggested route for overcoming that barrier. Based on the BBC format, each panellist will propose an issue that, if it were banished to that room of no return, would help mid-market law firms break through the current stasis between business objectives and the priorities of partners. And they'll identify a solution that could be the flip-side of that problem.
Using Sli.do – anonymously - the audience will debate and vote on each proposal before deciding which issue most deserves to go into Room 101 – and which corresponding solution will be the most workable. What will be banished forever to Room 101? This is your chance to close help mid-market firms overcome the single biggest obstacle on the journey towards long-term health and profitability.
- Simon Ross Managing Partner - Seddons Solicitors
- Tim Roche Head of IT - Stone King
- Tom Wagstaff Technology & Innovation Director - Birketts
- Jo Owen Chief Information Officer - Cripps
Your post-hack recovery plan and what you need to do pre-hack to make sure it works
We all know it's a matter of when, not if. And we also know that people are the weakest link in our cyber security chain. Now, we'll look at how you should respond in the first 24 hours to mitigate the scale of the theft with this practical guide to dealing with the fall-out from a significant security breach in your firm. An expert in incident response and digital forensics, Johannes advises on how, at the point of crisis, to respond quickly and effectively to cyber-attacks and data loss incidents. And what you can then do to pinpoint the perpetrators.
- Magnus Boyd Partner - Schillings
- Paul Price Associate, Cyber - Schillings
Networking lunch
This session marks the end of the Alternative Legal Management Summit 2018. The Alternative Legal IT Conference continues after lunch.


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Family Day at Waterford Ottawa
It's family day, and we are spending it together here at the Waterford Ottawa decorating all of the newly finished amenity areas including the Shallows Dining Room and our stunning … Read more
It's family day, and we are spending it together here at the Waterford Ottawa decorating all of the newly finished amenity areas including the Shallows Dining Room and our stunning … Read more
Click here to read the article about owner Karen Zlepning and her inspiring tale of how Windsong Memory Care for ladies evolved.
Dear Friends, It's a been a long year for all of us preparing for the opening of our Waterford home in Ottawa, formerly known to many of you as the … Read more
As we approach our grand opening this fall, many of the areas of the Waterford Ottawa are going through their last few stages of completion. This short video shows the … Read more
This milestone for the Ottawa Heart Institute was of great significance to the family as Fred and Karen's daughter, Jennifer, is a beneficiary of the institute's fine services not to … Read more
Construction continues on this beautiful snowy day in Ottawa's south end. The structural steel framing of the new assisted living dining of Ottawa's first Waterford is being erected as shown … Read more
It was an exciting day for those of us on site here at The Waterford Ottawa. The retractable roof structure that will provide year 'round access to out courtyard has … Read more
We are full force into the reno's of the Southway Hotel and Conference Centre as this makeover prepares the site for Ottawa's newest full service Retirement Residence. Click on the thumbnails to … Read more
This weekend, Jo-Anne (Waterford Ottawa) and Tracy (Waterford Kingston) will be at the EY Centre in Ottawa with great prizes and lots of smiles. Stop by and say 'Hello!' We would … Read more
The rumors are true! The Waterford will be opening very soon in Ottawa South. Stay tuned for more details and announcements. If you have any inquiries, please make sure you … Read more


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Contact us
We would be delighted to hear from you with any enquiries you may have. Please get in touch through our contact number or email below.
Contact Liv-Marie 07751 036427
Contact Simon 07813 043809
Our address (by appointment only):
Park Lodge, 170 Main Road, Cleeve, BS49 4PP
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Apps4BCN: the whole city in your smartphone
We always say that in Barcelona there are some hidden gems that make the difference when you find them: these can be charming streets, impressive little shops or unknown yet delicious restaurants… but sometimes it is just a website.
Apps4bcn.cat is a community of experts posting valuations on smartphone apps that can be very useful for your stay in Barcelona. Here you can find them classified by marks, use or newness.
This is an official Barcelona's city council web page, and is available in Spanish, Catalan and English. You can use your apartment's free wifi to access and download the apps you need the most.
Without any doubt, it will help you to live a better experience in the city!
Visit them here: Apps4bcn.cat


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40% Off Alpaca Inventory Sale +Estate Sale
February 4, 2017 8AM-2 PM
We're moving and that means it's time for us to clear out!
Because the Shabby warehouse is in my house and we're moving, we are having a massive sale because the less I have to move, the less grumpy I will be. All alpaca goods will be 40% off. We're combining this opportunity with an estate and household sale and we're serving coffee and donuts.
We'd love to see you at our home and warehouse on February 4! Keep reading for more info and scroll below to RSVP.
Click here to RSVP for our Alpaca Inventory Sale!
All alpaca goods will be 40% off. We have no qualms about giving you the best deals. We'll have apparel, stuffed animals, slippers +++. This is a great chance to get gifts or to buy the sweater you lusted after but didn't want to pay full price for. Don't miss this awesome sale.
Here are just a few of the household and estate items we will have for sale:
We will also have some furniture and kitchen items.
We'll have donuts and coffee as long as they last, so get here early!
Shabby Girls


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Good news to all Toronto residents; the Canadian Ski Council would like to welcome Centennial Park back into the Grade 4 and 5 SnowPass program for the 2014/15 ski and snowboard season! Centennial Park is located right in the heart of the Greater Toronto Area at the 401 and 427, making it easily accessible for so many families to enjoy a fun day on the slopes, without the long commute.
To learn more about Centennial Park, click here.
Is your child in Grade 4 or 5?
Visit www.snowpass.ca for more information on how your child can ski and snowboard for two full years for only $29.95!


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Can you believe it it's already August? It won't be long before it's Christmas. So I've started to create some Christmas cards now so when Christmas is here, I will have a nice supply of cards to send out.
Here are some that I've created using the Tree Trimmings stamp set fromthe New Mini and the lovely extra wide grosgrain ribbon.
Loving this mini!
Stamps: Tree Trimmings, Best Yet
Accessories: Ski Slope DSP, Glossy Cardstock, Baja Breeze Double Stitched Grosgrain ribbon,
Inks: Real Red, Baja Breeze, Old Olive, Basic Black
Stamps: Tree Trimmings, Snow Swirled
Accessories: Glossy Cardstock, Kiwi Kiss/Very Vanilla Satin ribbon,
Inks: Real Red, Baja Breeze, Old Olive, Basic Black
Stamps: Best Yet
Accessories: Ski Slope DSP, Riding Hood Red 1 1/4″ striped grosgrain ribbon, paper piercing, scallop oval punch, large oval punch
Inks: Real Red
Stamps: Sof t Summer, Great Friend
Accessories: Kiwi Kiss Striped Grosgrain ribbon, Scallop oval punch, large and small oval punch, scallop edge punch
Inks: Pink Pirouette, Regal Rose, Kiwi Kiss


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In college I wrote a medical ethics paper on a play titled "Whose Life Is It Anyway?" That old paper came to mind recently when I learned that the campaign for physician assisted suicide has been gaining momentum. The renewed push to legalize "aid in dying" or "death with dignity," as various groups euphemistically call it, is the result of positive media coverage in the wake of a young terminally ill woman's decision to end her life on her own terms and at the precise moment of her choosing.
Whose life is it anyway? I can't get this question out of my mind as I come to grips with the fact that assisted suicide legislation is currently being introduced in a dozen states and the District of Columbia. While some persons faced with serious illness consider taking their lives because they fear they will be a burden to others or have no one to care for them, for others this choice is a declaration of personal autonomy. To the question, "Whose life is it anyway?" they answer, "It is mine to do with what I want."
The claim that each of us is master of our own life, with the power to do with it whatever we choose, just doesn't make sense. After all, which of us chose the date, time or conditions of our birth? Who of us ultimately gets to choose the path that will lead to our death — will it be an accident, a random act of violence, a sudden heart attack or a prolonged illness? Human logic would tell us that we are never completely in control of our lives. God's word should convince us of this as well.
Sacred Scripture reminds us that we are God's creatures — made in his image and likeness — and that our lives are in his hands at every moment. From the psalmist's confession that "every one of my days was decreed before one of them came into being" (Ps. 139:16), to St. Paul's proclamation that "in him we live and move and have our being" (Acts 17:28), it is clear that God is the author of our existence. Each of us is a steward — not the master — of our own life.
But God is a loving master, and that makes all the difference. In his landmark encyclical, "The Gospel of Life," St. John Paul II wrote, "If it is true that human life is in the hands of God, it is no less true that these are loving hands, like those of a mother who accepts, nurtures and takes care of her child."
Pope Francis shared similar sentiments in his 2015 Lenten message: God "is not aloof from us. Each one of us has a place in his heart. He knows us by name, he cares for us and he seeks us out whenever we turn away from him."
In our sophisticated, materialistic society we easily turn away from God, denying him and his providence over us. Modern man, St. John Paul II wrote, has "lost the sense of God," and with it, the sense of the human person and his dignity as "mysteriously different" from the rest of creation. In this context we can easily succumb to the temptation to manipulate and dominate our lives rather than cherishing them as a gift. Suffering is seen as a useless burden to be eliminated at all cost, even if this means suppressing life itself.
There is another path, however. Even as the media focused their attention on a dying woman from California late last year, a similarly ill college freshman in Ohio vowed never to give up. Despite the seeming hopelessness of her situation, she professed her belief that God has the last say. This young woman has found a purpose in her suffering and insists that she still loves life. She keeps on giving of herself and is an inspiration to many.
I pray for this young woman and for all the elderly, disabled and those with terminal illnesses, that they may find peace and courage in the conviction that God knows them by name and holds them close to his heart. Strengthened by the sacraments and assisted by Our Lady and all the angels and saints, may they serenely abandon their lives into his hands.
Whose life is it anyway? God has given us this life as a gift and he expects us to cherish it as his good stewards.
Sister Constance Veit is director of vocations for the Little Sisters of the Poor.
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Lee's Summit, Missouri is a popular suburb of Kansas City that has received a plethora of accolades, awards and recognition for being a wonderful place to live. BusinessWeek magazine ranked it among the nation's best places to raise children, Money Magazine listed it on its "Top 100 Best Cities to Live in" in the nation, and it also made Missouri's list of the "Top 10 Happiest Places." With its popularity you might expect real estate in Lee's Summit to be unattainable, however the city has a number of truly remarkable subdivisions with excellent home options sure to please even the most discerning of home buyers.
One subdivision worth noting is Park Ridge. Park Ridge is a master-planned community featuring wooded and walkout home sites on gently rolling hills. There is an impressive clubhouse in the heart of Park Ridge, as well as a community swimming pool, cabana, fitness center and tennis courts. There are scenic walking trails throughout the community as well. Park Ridge is comprised of multiple smaller neighborhoods including The Manor, The Meadows, The Summit and Trails at Park Ridge. Park Ridge is surrounded by 7,809 acres of the beautiful Fleming Park and its two lakes and numerous walking trails.
Park Ridge Meadows is a great place to buy a single family home in this wonderful community. Homes in The Meadows at Park Ridge are constructed by some of the area's best builders. Homes in the community come in a variety of styles including reverse 1.5 story homes, two-story homes and 1.5 story homes. The Meadows has been described by its residents as picturesque and peaceful. Students that live in The Meadows at Park Ridge are served by the highly esteemed Blue Springs School District. Home sites in Park Ridge range from $49,500 to $120,000 and available homes typically range from around $320,000 to $425,000.
If you would like more information regarding homes for sale in the Meadows of Park Ridge in Lee's Summit, Missouri, please do not hesitate to contact us today.
Listing courtesy of Amber Shawhan of Chartwell Realty LLC.
The data relating to real estate displayed on this website comes in part from the Heartland Multiple Listing Service database compilation. The properties displayed on this website may not be all of the properties in the Heartland MLS database compilation, or all of the properties listed with other brokers participating in the Heartland MLS IDX program. Detailed information about the properties displayed on this website includes the name of the listing company.
The information displayed on this page is confidential, proprietary, and copyrighted information of Heartland Multiple Listing Service, Inc. ("Heartland MLS"). Copyright 2019, Heartland Multiple Listing Service, Inc. Heartland MLS and the company represented by this website do not make any warranty or representation concerning the timeliness or accuracy of the information displayed herein. In consideration for the receipt of the information on this page, the recipient agrees to use the information solely for the private noncommercial purpose of identifying a property in which the recipient has a good faith interest in acquiring. Data last updated . Terms of Use
Looking for the perfect home in the perfect place? Chances are you'll want to check here first.


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Directors Slam Russell Crowe's 'Water Diviner' Over Armenian Genocide Denial (Guest Blog)
"We do not know how Mr. Crowe and now Warner Bros. have ended up here — by ignorance alone or by bad luck," say writer-directors of "1915 The Movie"
Garin Hovannisian and Alec Mouhibian, co-directors of "1915 The Movie," below present an open letter to Warner Bros., regarding the film "The Water Diviner." On the April 24, 2015, the authors will mark the anniversary of the 1915 Armenian genocide along with tens of thousands of Armenians in a march from Hollywood Blvd. to the Turkish consulate to protest the country's ongoing denial of the tragedy. Similar events will be held in New York and other major cities across the globe. The filmmakers will then travel to Armenia to screen "1915" for the Armenian government and their Armenian Genocide Centennial Committee.
Dear Warner Bros:
On April 24, 2015, your studio is set to release Russell Crowe's directorial debut "The Water Diviner" — a historical drama about an Australian father who travels to Gallipoli, Turkey, in search of his dead sons, who were among the Australian troops that landed there in 1915. He discovers, among other things, that the Turks were never really his enemies. In fact they were the noble victims who ultimately triumphed against the imperial West in World War I.
The problem is that April 24, 2015, also happens to be the 100th anniversary of the Armenian Genocide, which was perpetrated by the very Turkish government whitewashed by "The Water Diviner." It was on April 24, 1915 — the night before the Gallipoli landing — that the Young Turk regime set into motion its unprecedented plan: the efficient deportation and slaughter of 1.5 million Armenians and the destruction of their homeland of thousands of years.
Also Read: 'Little Boy' and Me: What My Next Movie Teaches About Race, Stereotypes (Guest Blog)
To this day the Turkish government denies that a genocide ever happened. Through lobby groups in Washington, professors at Ivy League universities, and studios in Hollywood, it has been on a quiet century-long campaign to rewrite the history of 1915. Mr. Crowe's film goes to show how successful this campaign has been. Nobody watching "The Water Diviner" would know that Armenians had ever existed in the Ottoman Turkish Empire — let alone that they were being exterminated there in the first genocide of modern history.
If released, "The Water Diviner" will become the highest profile piece of propaganda ever produced in the service of genocide denial.
Of course we do not know how Mr. Crowe and now Warner Bros. have ended up here — by ignorance alone or by bad luck — so we remain polite in how we ask you to consider the consequences of what you are about to do. On April 24, millions of Armenians across the world will be marching on the streets of their cities to remember their dead and protest the ongoing denial of the Turkish government. A hundred thousand Armenians will be marching in Los Angeles, too. How do you expect us to react to the release of your film on the very day we are mourning our dead and demanding that Turkey face its dark past?
Also Read: 'Woman in Gold' Speaks to Children of Holocaust Survivors (Guest Blog)
"In the First World War (1914-1918), more than 37 million military personnel and civilians were killed or wounded," "The Water Diviner" concludes. "Over 8 million were listed as missing, presumed to have perished. This film is dedicated to all those who remain 'lost and nameless' and who live on in the hearts and memories of their families."
We simply wanted to inform you that the lost, nameless, and unrecognized Armenians, Greeks, Assyrians, and other minorities systematically slaughtered by the Turkish government in 1915 do, in fact, continue to live on in the hearts and memories of their families — in our hearts and memories.
Also Read: 500 Years a Slave? Deeds, Not Words (Guest Blog)
More: www.thewrap.com
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- Թուրքիայում վաճառքի է հանվել հայ վարպետի պատրաստած երաժշտական գործիք
- Composer and pianist Tatev Amiryan will perform a benefit concert in San Francisco
- Тhe new album of Alexander Arutiunian's music will soon be available in the world leading music stores
- Shahen Shahinyan was re-elected as the rector of Conservatory
- The film ''Ashough Gharib'' by Sergey Parajanov will be shown in Turkey
- It is planned to develop a tourism development plan for Ashtarak
- Racist scraping appeared again on the wall of Armenian school in Istanbul
- Armenian Culture Days held in Egypt
- National Academic Theatre after Gabriel Sundukyan is ready for operation after renovation
- Aramyants' mansion from the perspective of tourism industry development can be very attractive. Prime Minister
- System of a Down will release a new album
- Dmitry Shostakovich and Johannes Brahms compositions at Khachaturian's Festival
- The President of Belgium Senate visited the Armenian Genocide Museum-Institute
- Painter Bill Plympton's visit to Armenia is finished
- 200-year-old Armenian rock-cut church is being destroyed by Kurdish embezzlers
- Dresden Symphonic Orchestra invited Turkish President Recep Tayyip Erdogan to be present at the concert dedicated to Armenian Genocide
- The Spain Malaga city recognized Armenian Genocide
- Dee Dee Bridgewater: ''Yerevan became for me a source of inspiration for new creative ideas ''
- An event dedicated to 25th anniversary of Armenia's independence in London


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His Robot Girlfriend
Paperback, 140 Pages
Price: $3.99
Prints in 3-5 business days
Mike Smith's life was crap, living all alone, years after his wife had died and his children had grown up and moved away. Then he saw the commercial for the Daffodil. Far more than other robots, the Daffodil could become anything and everything he wanted it to be. Mike's life is about to change.
Ratings & ReviewsLog in to review this item
1 Person Reviewed This Product
Jan 2, 2014Just found out that His Robot Girlfriend was available on paperback, so I couldn't resist purchasing them. But I couldn't find His Robot Wife Patients is a virtue on paperback. I will be purchasing it if it becomes available on paperback along with book 4.
There are no reviews for previous versions of this product
Product Details
- Copyright
- Wesley Allison (Standard Copyright License)
- Edition
- First Edition
- Publisher
- City of Amathar Press
- Published
- December 17, 2009
- Language
- English
- Pages
- 140
- Binding
- Perfect-bound Paperback
- Interior Ink
- Black & white
- Weight
- 1.02 lbs.
- Dimensions (inches)
- 5.5 wide x 8.5 tall
- Product ID
- 6152120
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