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Dissemination (including electronic) of all results must acknowledge EU funding. See below for details.
Marco Viceconti and his team at the Insigneo Institute, part of the University of Sheffield have collated and written a report on the CompBioMed solutions and end-user engagement of our Core Partners. We are currently in the process of extending this to our Associate Partners
|A New Pathology in the Simulation of Chaotic Dynamical Systems on Digital Computers
|A. Potterton, F. Husseini, M. Southey, M. Bodkin, A. Heifetz, P. V. Coveney, A. Townsend-Nicholson, Advanced Theory and Simulations, 1900125, 2019, DOI:10.1002/adts.201900125
|Systematic distortions are uncovered in the statistical properties of chaotic dynamical systems when represented and simulated on digital computers using standard IEEE floating-point numbers. This is done by studying a model chaotic dynamical system with a single free parameter β known as the generalized Bernoulli map, many of whose exact properties are known. Much of the structure of the dynamical system is lost in the floating-point representation. For even integer values of the parameter, the long time behaviour is completely wrong, subsuming the known anomalous behaviour for β=2. For non-integer β, relative errors in observables can reach 14%. For odd integer values of β, floating-point results are more accurate, but still produce relative errors two orders of magnitude larger than those attributable to roundoff. The analysis indicates that the pathology described, which cannot be mitigated by increasing the precision of the floating point numbers, is are presentative example of a deeper problem in the computation of expectation values for chaotic systems. The findings sound a warning about the uncritical application of numerical methods in studies of the statistical properties of chaotic dynamical systems, such as are routinely performed throughout computational science, including turbulence and molecular dynamics.
|Ensemble-Based Steered Molecular Dynamics Predicts Relative Residence Time of A2A Receptor Binders
|A. Potterton, F. Husseini, M. Southey, M. Bodkin, A. Heifetz, P. V. Coveney, A. Townsend-Nicholson, Journal of Chemical Theory and Computation, 15 (5), 3316–3330 2019, 10.1021/acs.jctc.8b01270
|We present a novel computational method for the reliable prediction of relative drug-target residence time. From ensemble-based steered molecular dynamics simulations, the change in energy between the ligand and water during dissociation (∆ELW) is obtained. These calculated ∆ELW values correlate strongly to the associated experimental residence times of 17 Adenosine A2A receptor ligands, a prototypical class A GPCR.
|Application of ESMACS binding free energy protocols to diverse datasets:Bromodomain-containing protein 4
|D. W. Wright, S. Wan, C. Meyer, H. van Vlijmen, G. Tresadern, P. V. Coveney, Scientific Reports, 9, 6017, 2019, 10.26434/chemrxiv.7327019
|We investigate the robustness of our ensemble molecular dynamics binding free energy protocols, known as ESMACS, to different choices of forcefield, starting structure and analysis. ESMACS is based on MMPBSA and we examinge the influence of multiple trajectories, explicit water molecules and estimates of the entropic contribution to the binding free energy.
|Ensemble-based replica exchange alchemical free energy methods: the effect of protein mutations on inhibitor binding
|A. P. Bhati, S. Wan, and P. V. Coveney, J. Chem. Theory Comput., 2018, 10.1021/acs.jctc.8b01118
|The accurate prediction of the binding affinity changes of drugs caused by protein mutations is a major goal in clinical personalized medicine. We have developed an ensemble-based free energy approach called thermodynamic integration with enhanced sampling (TIES), which yields accurate, precise, and reproducible binding affinities. These techniques bring us closer to a future where simulation is used to determine drug efficacy for each individual.
|Fully coupled Fluid-electro-mechanical model of the human heart for supercomputers
|Santiago A, Zavala‐Aké M, Aguado‐Sierra J, Doste R, Gómez S, Arís R, Cajas J C, Casoni E, Vázquez M, Int. J. Numer. Meth. Biomed. Engng., 2018, 10.1002/cnm.3140
|A computational fluid dynamics study of four highly detailed human left ventricular geometries is presented and compared to smoothed geometries regarding hemodynamic parameters. A porous layer is proposed as a method to incorporate the complex hemodynamics in smoothed models. This study characterizes the dynamics of left ventricular blood flow to examine the impact of trabeculae and papillary muscles using high performance computing (HPC).
|Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterisation after myocardial infarction
|M. López-Yunta, D. G. León, J. M. Alfonso-Almazán, M. Marina-Breysse, J. G. Quintanilla, J. Sánchez-González, C. Galán-Arriola, V. Cañadas-Godoy, D. Enríquez-Vázquez, C. Torres, B. Ibáñez, J. Pérez-Villacastín, N. Pérez-Castellano, J. Julie, M. Vázquez, J. Aguado-Sierra, D. Filgueiras-Rama, Europace, 2018, 10.1093/europace/euy192
|The first fluid-electro-mechanical model of the human heart is presented. Such a model allows to analyse all the physics involved in the heartbeat in a whole heart geometrical description. Such an integrative description of the heartbeat provides to a better understanding of complex cardiopathies.
|Influence of fiber connectivity in simulations of cardiac biomechanics
|D. Gil, R. Aris, A. Borras, E. Ramirez, R. Sebastian, M. Vazquez, International Journal of Computer Assisted Radiology and Surgery, 2018, 10.1007/s11548-018-1849-9
|This work explores the influence of the fiber distribution that is used in cardiac simulations. The results show that fibers extracted from experimental data produce functional scores closer to healthy ranges than mathematical models. This study contributes to understand that deep knowledge of cardiac fiber field is important to achieve more realistic results in computational modelling.
|PlayMolecule BindScope: large scale CNN-based virtual screening on the web
|M. Skalic, G. Martínez-Rosell, J. Jiménez, G. De Fabritiis, Bioinformatics, 2018, 10.1093/bioinformatics/bty758
|A deep learning method to distinguish active from non-active ligands for large-scale virtual screening of drug candidates, which is made available in an easy-to-use web platform. Bindscope accelerates the inital stages of drug-discovery, speeding up the time required for novel drug development.
|Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour
|M. de Haan, G. Závodszky, V. Azizi, A. G. Hoekstra, Applied Sciences, 8(9), 1616, 2018, 10.3390/app8091616
|Assessing the influence of taking into account the internal viscosity of red blood cells on the properties of whole blood.
|Cell-resolved blood flow simulations of saccular aneurysms: effect of pulsatility and aspect ratio
|B. Czaja, G. Závodszky, V. Azizi Tarksalooyey, A. G. Hoekstra, Journal of the Royal Society Interface, 2018, 10.1098/rsif.2018.0485
|How do geomatical properties of aneurysms influence the transport of platelets into these aneurysms.
|Inflow and outflow boundary conditions for 2D suspension simulations with the immersed boundary lattice Boltzaman method
|V. Azizi Tarksalooyeh, G. Závodszky, B. J. M. van Rooij, A. G. Hoekstra, Computers & Fluids, 2018, 10.1016/j.compfluid.2018.04.025
|An algorithm for establishing inlet and outlet conditions for simulations of bloodflow explicitly following every single red blood cell in the blood.
|Patterns for High Performance Multiscale Computing
|S. Alowayyed, T. Piontek, J. L. Suter, O. Hoenen, D. Groen, O. Luk, B. Bosak, P. Kopta, K. Kurowski, O. Perks, K. Brabazon, V. Jancauskas, D. Coster, P.V. Coveney, A.G. Hoekstra, Future Generation Computer Systems, 91, 335-346 2018, 10.1016/j.future.2018.08.045
|We present a generic implementation to effectively use supercomputers for (multiscale) models, including biomedical ones. The software simplifies and automates the execution of complex multiscale simulations on High-Performance Computers (HPC), delivering performance benefits from both the end-user and the HPC system level perspectives.
|Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis
|A. Nikishova, L. Veen, P. Zun, A. G. Hoekstra, Cardiovascular Engineering and Technology, 1-4, 2018, 10.1007/s13239-018-00372-4
|Estimating the uncertainties in models of scar tissue prediction in treatment of stenosed coronary arteries.
|Parameter Estimation of Platelets Deposition: Approximate Bayesian Computation with High Performance Computing
|R. Dutta, B. Chopard, J. Latt, F. Dubois, K.Z. Boudjeltia, A. Mira, Front Physiol, 2018, 10.3389/fphys.2018.01128
|Cerebral aneurysms can be treated by inserting a flow-diverter in the parent artery. This study proposes simulations involving a coarse grained description of a flow-diverter, based on a screen approach rather than a porous media. Through simulations we can advance our understanding of this aneurysm treatment, leading to improvements and new approaches.
|LigVoxel: Inpainting binding pockets using 3D-convolutional neural networks
|M. Skalic, A. Varela-Rial, J. Jimenez, G. Martinez-Rosell, G. De Fabritiis, Bioinformatics , 2018, 10.1093/bioinformatics/bty583
|A deep learning method to infer pharmocophore-like properties in binding pocket of proteins to aid in the drug discovery process. This computational method speeds up the design of novel molecules, and assists the improvement of potential drug candidates.
|Simulations meet machine learning in structural biology
|A. Perez, G. Martinez-Rosell, G. De Fabritiis, Current Opinion in Structural Biology , 2018, 10.1016/j.sbi.2018.02.004
|Review article on the impact of the latest machine learning methods in MD simulations and structural biology and a future perspective on the field. This review points out the impact machine learning can have on molecular simulations and all the scientific results coming from them.
|Left Ventricular Trabeculations Decrease the Wall Shear Stress and Increase the Intra-Ventricular Pressure Drop in CFD Simulations
|F. Sacco, B. Pain, O. Lehmkuhl, T.L. Iles, P.A. Iaizzo, G. Houzeaux, M. Vazquez, C. Butakoff, J. Aguado-Sierra, Frontiers in Physiology, 2018, 10.3389/fphys.2018.00458
|A quantification of the resolution of in-vivo versus ex-vivo measurements of a model of monomorphic Ventricular Tachycardia in a pig model, particularly regarding scar characterisation. In-vivo clinical measurement techniques over-estimate the scar volume quantified using gadolinium enhanced MRI. Characterization of scar is important to achieve personalized cardiac models.
|Evaluating the roles of detailed endocardial structures on right ventricular haemodynamics by means of CFD simulations
|F. Sacco, B. Pain, O. Lehmkuhl, T.L. Iles, P.A. Iaizzo, G. Houzeaux, M. Vazquez, C. Butakoff, J. Aguado-Sierra, International Journal for Numerical Methods in Biomedical Engineering, 2018, 10.1002/cnm.3115
|A detailed computational fluid dynamics study is performed in four human male and female heart geometries that include structural resolution of around 1 mm^2 cross-section. Wall shear stress, pressure drop and turbulence are some of the quantifications presented. This work shows that neglecting internal structures in cardiac models may lead to inaccurate measures in the cavity.
|A mechanistic model for predicting cell surface presentation of competing peptides by MHC class I molecules
|D. S. M. Boulanger, R. C. Eccleston, A. Phillips, P. V. Coveney, T. Elliott, N. Dalchau, Frontiers Immunology, 2018, 10.3389/fimmu.2018.01538
|We develop and experimentally verify a mechanistic model for presentation of peptides to major histocompatibility complex-I (MHC-I) molecules. The resulting model can be used to predict key steps in the processing of intracellular peptides, which play an important role in inflammatory immune responses to viruses and cancer.
|Validation of patient-specific cerebral blood flow simulation using transcranial Doppler measurements
|D. Groen, R. A. Richardson, R. Coy, U. D. Schiller, H. Chandrashekar, F. Robertson, P. V. Coveney, Frontiers Physiology, 2018, 10.3389/fphys.2018.00721
|We show that the HemeLB simulation code is able to reproduce velocities measured using transcranial Doppler in a cerebral artery, with an error of less than 9% in the given validation setting. HemeLB allows the study of blood flow systems such as aneurysms, by improving our understanding of aneurysms through simulation, we can improve and discover new treatments and preventions.
|PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling
|M. O. Bernabeu, M. L. Jones, R. W. Nash, A. Pezzarossa, P. V. Coveney, H. Gerhardt, and C. A. Franco, Biophysical Journal, 114 (9), 2052-2058 2018, 10.1016/j.bpj.2018.03.032
|PolNet is an open-source software tool for the study of blood flow and cell-level biological activity during vessel morphogenesis. PolNet will be a powerful analysis method to address the complexity of endothelial cell biology at the network level in intact organs.
|Uncertainty Quantification in Alchemical Free Energy Methods
|A. Bhati, S. Wan, Y. Hu, B. Sherborne, P. V. Coveney, Journal of Chemical Theory and Computation, 14 (6), 2867-2880 2018, 10.1021/acs.jctc.7b01143
|This study provides a systematic approach to uncertainty quantification based on ensemble simulations, which is generally applicable to all free energy calculation methods that draw on classical molecular dynamics.
|Investigating the mechanical response of paediatric bone under bending and torsion using finite element analysis
|Z. Altai, M. Viceconti, A. C. Offiah, X. Li, Biomechanics and Modeling in Mechanobiology, 2018, 10.1007/s10237-018-1008-9
|This is the first study to quantitatively analyse the infant bone strength under different loading conditions. The results are precious to the research into childhood bone diseases and fractures, especially those in the very young age range. This research could contribute to new medical treatments and preventions of bone diseases and fractures.
|Modeling Patient-Specific Magnetic Drug Targeting Within the Intracranial Vasculature
|A. Patronis, R. A. Richardson, S. Schmieschek, B. J. N. Wylie, R. W. Nash, P. V. Coveney, Frontiers in Physiology, 2018, 10.3389/fphys.2018.00331
|We have applied our magnetic-drug targeting model to paramagnetic-nanoparticle-laden flows in a circle of Willis geometry obtained from an MRI scan; we note a strong dependence of the particle density (at a target site) on the strength of the magnetic forcing and the velocity of the background fluid flow. The capability and excellent computational performance of the model allow us to address flow problems that previously could not be approached, and will lead to new a level of understanding.
|Predicting Binding Free Energies of PDE2 Inhibitors. The Difficulties of Protein Conformation
|L. Pérez-Benito, H. Keränen, H. van Vlijmen & G. Tresadern, Scientific Reports, 8, 4833, 2018, 10.1038/s41598-018-23039-5
|This work shows that computational methods can help to predict the interaction energy between candidate drug molecules and their target protein, although the inherent flexibility of proteins makes this more difficult than expected. Large computational resources are required for these accurate calculations, but correct predictions could greatly enhance the role of computational assisted drug design.
|KDEEP: Protein-Ligand Absolute Binding Affinity Prediction via 3D-Convolutional Neural Networks
|J. Jimenez, M. Skalic, G. Martinez-Rosell, G. De Fabritiis, J. Chem. Inf. Model.,, 52 (8), 287-296, 2018, 10.1021/acs.jcim.7b00650
|A deep learning method to predict how strongly ligands bind to proteins in presented and validated, providing fast predictions with similar accuracy compared with other state-of-the-art methods. KDEEP accelerates the inital stages of drug-discovery, speeding up the time required for novel drug development.
|Computational Methods for GPCR Drug Discovery
|A. Heifetz, Springer, 1705, 2018, 10.1007/978-1-4939-7465-8
|This book explores drug interaction with proteins, G protein-coupled receptors (GPCR), that are a common target for pharmaceuticals. The book provides an overview of modern computational strategies and techniques employed in the field of GPCR drug discovery. By exploring and developing such computational methods, we move closer to a future where drug design is regularly informed by simulations.
|Synergistic Use of GPCR Modeling and SDM Experiments to Understand Ligand Binding
|A. Potterton, A. Heifetz, A. Townsend-Nicholson, Methods Mol Biol., 1705, 335-343, 2018, 10.1007/978-1-4939-7465-8_15
|There is a substantial amount of historical ligand binding data available from site-directed mutagenesis (SDM) studies of many different GPCR (G-protein-coupled receptor) subtypes. We describe a protocol by which historic SDM binding data and receptor models may be used together to identify novel key residues for mutagenesis studies.
|Unlocking data sets by calibrating populations of model to data density: A study in atrial electrophysiology
|B. A. J. Lawson, C. C. Drovandi, N. Cusimano, P. Burrage, B. Rodriguez, K. Burrage, Science Advances, 4 (1), 2018, 10.1126/sciadv.1701676
|This study describes the ability of a parameter sampling algorithm to produce populations of models calibrated to data distributions.
|Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery
|A. Heifetz, M. Southey, I. Morao, A. Townsend-Nicholson, M. Bodkin, Methods Mol Biol., 1705, 375-394 2018, 10.1007/978-1-4939-7465-8_19
|This book chapter explores drug interaction with proteins, G protein-coupled receptors (GPCR), that are a common target for pharmaceuticals. The chapter explores the modern computational strategy of Hit-to-Lead and Lead Optimization Stages of Structure-Based GPCR Drug Discovery. By exploring and developing such computational methods, we move closer to a future where drug design is regularly informed by simulations.
|The application of the screen model for stents in cerebral aneurysms
|S. Li, J. Latt, B. Chopard, Computer Fluids., 172, 651-660 2018, 10.1016/j.compfluid.2018.02.007
|Cerebral aneurysms can be treated by inserting a flow-diverter in the parent artery. This study proposes simulations involving a coarse grained description of a flow-diverter, advancing a previous study by validating the proposed model to complex flow problems and quantifying the benefit of the approach in term of computing speed and accuracy. Through simulations we can advance our understanding of this aneurysm treatment, leading to improvements and new approaches.
|Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity
|A. Kapoor, G. Martinez-Rosell, D. Provasi, G. Fabritiis, M Filizola, Scientific Reports, 7, 11255 2017, 10.1038/s41598-017-11483-8
|An application of high-throughput methods and kinetic analysis to an important protein family for drug-targeting (GPCR), related to mental-health diseases and cancer. These results provide important insights to develop better drugs for GPCR related diseases.
|Model for pressure drop and flow deflection in the numerical simulation of stents in aneurysms. International journal for numerical methods in biomedical engineering
|S. Li, J. Latt, B. Chopard, International Journal for Numerical Methods in Biomedical Engineering, 2017, 10.1002/cnm.2949
|Cerebral aneurysms can be treated by inserting a flow-diverter in the parent artery. This study proposes simulations involving a coarse grained description of a flow-diverter, including patient specific cases. Through simulations we can advance our understanding of this aneurysm treatment, leading to improvements and new approaches.
|Parameter estimation of platelets deposition: Approximate Bayesian computation with high performance computing
|R. Dutta, B. Chopard, J. Lätt, F. Dubois, K. Boudjeltia, A. Mira, arXiv, 2017, arxiv.org/abs/1710.01054
|Current platelet function tests are acknowledge to poorly detect various pathology that affect blood. In this paper we propose a methodology which combines clinical images of platelets deposition, a mathematical model of the deposition process, and a HPC machine learning approach to calibrate the model parameters to match the clinical images. From this approach we are able to determine the deposition rates of platelets and detect anomalies. By improving platelet tests through simulation, we can improve the accuracy and capabilities of the medical testing of conditions and diseases.
|Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances
|A. Lyon, A. Michole, J.P.Martinez, P.Laguna, B. Rodriguez, Journal of the Royal Society Interface, 15 (138)2017, 10.1098/rsif.2017.0821
|This is a review of the computational techniques that have been proposed for ECG analysis and computer simulations.
|In silico evaluation of arrhythmia
|X. Zhou, A. Bueno-Orovio, B-Rodriguez, Current Opinion in Physiology, 1, 95-103, 2017, 10.1016/j.cophys.2017.11.003
|This study highlights key studies in the field of computational simulations of arrhythmia
|Host genotype and time dependent antigen presentation of viral peptides: predictions from theory
|R. Eccleston, P. V. Coveney, and N. Dalchau, Scientific Reports, 7 (1), 14367, 2017, 10.1038/s41598-017-14415-8
|We construct a model of the recognition of HIV infection by the MHC (Major Histocompatibility Complex) class I pathway. The model is predictive and useful for helping to design experiments that provide a mechanistic understanding of immune recognition.
|Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: An in silico approach
|M. Paci, E. Passini, S. Severi, J. Hyttinen, B. Rodriguez, Heart Rhythm, 2017, 10.1016/j.hrthm.2017.07.026
|The study demonstrates, through the simulation of cell populations, the effect mutations in the electrophysiology of stem cell derived cardiomyocytes.
|β-adrenergic receptor stimulation inhibits proarrhythmic alternans in post-infarction border zone cardiomyocytes: a computational analysis
|MJ. Tomek, B. Rodriguez, G. Bub, J. Heijman, American Journal of Physiology – Heart and Circulatory Physiology, 2017, 10.1152/ajpheart.00094.2017
|The study demonstrates the anti-arrhythmic effects of beta-adrenergic stimulation post-myocardial infarction using detailed computer simulations.
|Cellular Level In-silico Modeling of Blood Rheology with An Improved Material Model for Red Blood Cells
|G. Závodszky, B. van Rooij, V. Azizi and A. Hoekstra, Front. Physiol., 2017, 10.3389/fphys.2017.00563
|A detailed model of blood flow based on modelling every single cell in a cubic millimeter of blood and validation against experimental data.
|Multiscale Computing in the Exascale Era
|S. Alowayyed, D. Groen, P. V. Coveney, A. G. Hoekstra, Journal of Computational Science, 2017, 10.1016/j.jocs.2017.07.004
|A vision on how to execute simulations that span multiple scale on the most powerful supercomputers that exist today, and those that will be available in the near future.
|Rapid and accurate assessment of GPCR–ligand interactions Using the fragment molecular orbital-based density-functional tight-binding method
|I. Morao, D. G. Fedorov, R. Robinson, M. Southey, A. Townsend-Nicholson, M. J. Bodkin, A. Heifetz, Journal of Computational Science, 2017, 10.1002/jcc.24850
|This paper explores drug interaction with proteins, G protein-coupled receptors, that are a common target for pharmaceuticals. With the particular computer simulation method harnessed in this work, the computational cost is decreased 1000-fold. By exploring and developing such computational methods, we move closer to a future where drug design is regularly informed by simulations.
|The role of multiscale protein dynamics in antigen presentation and T lymphocyte recognition
|R. C. Eccleston, S. Wan, N. Dalchau, P. V. Coveney, Frontiers in Immunology, 2017, 10.3389/fimmu.2017.00797
|We advocate a mechanistic description of antigen presentation and TCR (T-cell receptor), which involves multiscale modelling approaches collectively span several length and time scales. The approaches are capable of furnishing reliable biological descriptions that are difficult for experimentalists to provide.
|A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to In-vivo Data
|P. S. Zun, T. Anikina, A. Svitenkov, A. G. Hoekstra, Frontiers in Physiology, 8, 1-12, 2017, 10.3389/fphys.2017.00284
|A model for scar tissue in coronary arteries after treatment of stenosis compared to data from animal experiments.
|Exact solutions to the fractional time-space Bloch–Torrey equation for magnetic resonance imaging
|A. Bueno-Orovio, K. Burrage, Commun Nonlinear Sci Numer Simulat., 52, 91-109, 2017, 10.1016/j.cnsns.2017.04.013
|This study demonstrate the exact solutions to the fractional time-space Bloch-Torrey equation for application in magnetic resonance imaging.
|An Ensemble-Based Protocol for the Computational Prediction of Helix-Helix Interactions in G Protein-Coupled Receptors using Coarse-Grained Molecular Dynamics
|N. Altwaijry, M. Baron, D. Wright, P. V. Coveney, A. Townsend-Nicholson, Journal of Chemical Theory & Computation, 13 (5), 2254-2270, 2017, 10.1021/acs.jctc.6b01246
|We provide a systematic, reproducible, and reliable protocol for determining the specific points of interaction between GPCR dimers. Our method is of great utility in further understanding GPCR function and also has broad applicability to many different types of membrane proteins.
|Evaluation and Characterization of Trk Kinase Inhibitors for the Treatment of Pain: Reliable Binding Affinity Predictions from Theory and Computation
|S. Wan, A. Bhati, S. Skerratt, K. Omoto, V. Shanmugasundaram, S. Bagal, P. V. Coveney, Journal of Chemical Information and Modelling, 57 (4), 897-909, 2017, 10.1021/acs.jcim.6b00780
|The paper presents free energy methods which could be used as tools to guide lead optimization efforts across multiple prospective structurally enabled programs in the drug discovery setting for a wide range of compounds and targets.
|Opinion: Is big data just big hype?
|P. V. Coveney and R. Highfield, Longevity Bulletin: Big data in health, Institute and Faculty of Actuaries, 11-12, 2017, ISSN 2397-7213
|To effectively use the explosion in big data, we need to understand the characteristics and sensitivity of the complex systems. The paper emphasises the importance of tools and models for pattern extraction and visualization, which need to be truly predictive.
|Rapid and Reliable Binding Affinity Prediction of Bromodomain Inhibitors: a Computational Study
|S. Wan, A. P. Bhati, S. J. Zasada, I. Wall, D. Green, P. Bamborough, and P. V. Coveney, J. Chem. Theory Comput., 13 (2), 784-795, 2017, 10.1021/acs.jctc.6b00794
|In collaboration with GlaxoSmithKline, we apply our ensemble based free energy approaches to accurately rank ligands by their binding free energies. The approach offers a long awaited development in the field of structure-based drug design.
|Functional identification of islet cell types by electrophysiological fingerprinting
|L. J. B. Briant, Q. Zhang, E. Vergari, J. A. Kellard, B. Rodriguez, F. M. Ashcroft, P. Rorsman, Journal of Royal Society Interface, 14 (128), 1-20, 2017, DOI: 10.1098/rsif.2016.0999
|This study shows the identification of islet cell types using electrophysiological information.
|Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics
|C. Shanchez, A. Bueno-Orovio, E. Pueyo, B. Rodriguez, Front. Bioeng. Biotechnol., 5, 1-13, 2017, DOI: 10.3389/fbioe.2017.00029
|The study demonstrates HPC simulations of differences in atrial arrhythmias using six heterogeneous human three-dimensional models of atrial electrophysiology
|Rapid, accurate, precise and reliable relative free energy prediction using ensemble based thermodynamic integration
|A. Bhati, S. Wan, D. Wright, P. V. Coveney, Journal of Chemical Theory and Computation, 13 (1), 210-222, 2017, 10.1021/acs.jctc.6b00979
|We apply a systematic protocol for uncertainty quantification to a number of popular free energy methods. With a reliable measure of error estimation, ensemble-based simulations can be used to predict relative free energies accurately.
Dissemination (including electronic) of all results must:
- Display the EU emblem
- Include the following text for anything published up to September 2019: "This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 675451 (CompBioMed project)"
- Include the following text for anything published after October 2019: "This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 823712 (CompBioMed2 project)"
Any dissemination of results must indicate that it reflects only the author's view and that the Commission is not responsible for any use that may be made of the information it contains


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Nivea Anti-Perspirant Invisible for Black & White Deodorant Buy 2 Free 1 50ml
Product Description
48h clear, gentle care, 3x effect brighter, smoother & dryer, Protection & care, White marks protection on black clothes, Anti-yellow staining on white clothes, 48 hours protection, Dermatologically tested, No alcohol
Anti-Perspirant Invisible for Black & White Deodorant
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Made in Thailand
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Importer Address
Beiersdorf Malaysia Sdn. Bhd.,
T1-L12, Level 12,
3, Jalan Semangat,
46200 Petaling Jaya,
Distributor Address
Beiersdorf Malaysia Sdn. Bhd.,
T1-L12, Level 12,
3, Jalan Semangat,
46200 Petaling Jaya,
Return To
Beiersdorf Malaysia Sdn. Bhd.,
T1-L12, Level 12,
3, Jalan Semangat,
46200 Petaling Jaya,
Tel: (603) 7957 8177
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Number of Units - 3
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Numeric Size - 50
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subset: commoncrawl


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By using Amazon AppStream 2.0, Fife Public School's students can now access applications from anywhere, anytime, on any device. Fife Public Schools in Washington aspires to be a top-tier learning organization in which all students are being prepared for college, career, and life. Fife School District provides a device for every kid in the district. While the kids automatically got access to some applications, there were certain programs they couldn't access, especially those used in CTE (Careers in Technical Education) classes. In addition to providing equitable access with Amazon AppStream 2.0, the district turned labs back into learning spaces, which saved the district money it would have otherwise spent on building costs.
Learn more about AWS for K12 and primary schools.


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Old Friends
Victoria is a Catholic Navy wife and a new mom. Dahvie is an incarcerated Chicago gang member. They write letters back and forth (you can learn more about it here). In this post, Victoria shares her fears of drifting apart from dear friends of hers, and Dahvie muses on how people change.
Victoria: I had two of my dearest friends from college (they're a couple) travel down from VA to visit my husband and me in Mississippi for a week. It was so good to have them down here with us—we went on hikes, explored New Orleans for a couple of days, played the board game Life drunk (10 out of 10 would recommend)—and it was just so good to be with them. I've been working on making new friends down here but sometimes what you really need is old friends that you're comfortable with.
What's weird though is that I was struck by how much we'd changed. When we were in school, our paths were so similar: going to classes, studying, eating in dhall, more studying, even more studying… Now it's becoming apparent how different our goals are: I want a ton of kids and to maybe homeschool those kids and perhaps never formally work ever again, and they're totally career-oriented. She's at a fantastic med school and is going to be an incredible doctor and I don't think they want kids. I'm so excited for them but I wonder sometimes if in the future our lives will be so different that we won't understand each other.
At the same time, things were still kinda just the same. In many ways were still just their old, goofy selves. We still loved walking, hiking, exploring museums, and visiting new towns together. He and I still blurt out whatever we're thinking. They're still vegetable and peanut butter obsessed, compost everything, and work to help the environment in every way possible (I was super inspired—I hadn't started recycling in the new place). And, we still sang along to ever word of The Killers' CD Direct Hits together (how you know you'll be friends forever, lol).
Dahvie: Friends! Ones we can depend on…Lol. This such a cool post. I like how you still in contact with old homies from college. What's crazy is they still a couple? Or over time they got together? It's good to know you got friends that will travel to come kick it with you. That's love.
People change. Of course you can't be surprised about that. Nothing ever stay the same. Relationships change. People who share the same hobbies, views in life, or goals is what link them together. Y'all goals may change, views or even hobbies but as long as something yall share remain in common then your friendship is good. But if everything is different and yall don't find common ground sad to say yall grew apart. You never know if you don't ask.
Have you asked her and told her what you feeling? Maybe she didn't expect life to turn the way it did and even yearn for the old dream. I can tell you don't worry that one day yall might end up too different. That shouldn't happen. Individual time could prevent that. Not couple dates. Get it? That way you can find that uniqueness that excite you in that person and base your bond off that. Make sense?
And are you for real going to have a ton of kids? Like how many? Damn, your husband's got his hands full, lol.
Can't lie yall activities sounded fun but I must ask how can someone love walkin…that's like…weird I think.


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Awesome Hans Olsen Dining Set Creative
Hans Olsen Dining Set – There's little doubt that Adirondack chairs are a preferred selection of furniture, particularly within outdoor areas from the property. It's most typical to discover Adirondack style chairs found out in poolside areas where they'll be scattered tastefully all around the edge from the pool in an effort to provide comfortable seating space.
There are many several types of these kinds of chairs, and if you're a first-time buyer curious about purchasing some it will be a great idea to discover what the very best ones are. Weighing the costs and benefits of different Adirondack chairs can help you make the ideal decision.
What kinds of chair should I buy?
Among the different kinds of chairs that can be found to purchase, the most typical are plastic Adirondack chairs and wooden versions. Each kinds of chair has its own benefits along with one or two disadvantages. While It's true that an Adirondack chair constructed from wood will look attractive and remain highly durable, inside an outdoor environment where exposure to water is common It's likely the wood could degrade or lose color as time passes. Another possible disadvantage is wooden chairs tend to become more highly priced, so buyers on less budget may not be in a position to afford them.
Learning more plastic Adirondack chairs
Some people think that the typical poolside chair made out of plastic is made of poor quality, these chairs are highly versatile and resistant to discoloration. The reason being they're made out of dense Polywood or recycled plastic resistant to damage and built beautifully designed. Plastic Adirondack chairs happen to be tested by professionals on multiple occasions and commonly reviewed positively. This can be because of the cost / quality advantage they possess. To outfit your pool or porch area with plastic Adirondack chairs vs. wooden ones would indicate a lot lower purchase price and a very good return for money because of total chair life expectancy.
Finding a very good store to purchase plastic Adirondack chairs
Anyone who has evolved to purchase quality chairs made out of plastic will require to get yourself a quality manufacturer. Above all, you'll need plastic that's thick and durable, designed to resist environmental damage and discoloration. Higher quality chairs ought to be fairly easy to locate in case you search for any well-known and established store in your town or perhaps online. Higher quality plastic chairs by having an Adirondack style could be expected to cost a bit more than regular cheap plastic, but it may be well worthwhile to take a position in plastic materials which have been proven to last longer and provides a better degree of comfort.
Checking pros and cons of Adirondack style chairs made out of wood vs. those made from plastic, It's clear that there are a lot of reasons why the typical customer should choose plastic like a primary material. An excellent plastic chair can take a little time to locate but searching for any superior product is usually worthwhile. Good Adirondack chairs could be purchased in bulk from your assorted sort of top quality manufacturers both on the internet and with your local area.
13 Picture Gallery: Awesome Hans Olsen Dining Set Creative
This post topic: Decor, Home Furnitures


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Welcome to the Soul Sacrifice wiki Basics section. Within these pages, you will find guides on how to start-up the game and transfer demo save files, the essentials of combat (including how to sacrifice and elemental affinities), and Multiplayer Tips for your first foray into cooperative play.
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text: Jabong PhonePe Offer Get 10% Cashback Upto Rs.125 December 20, 2018 By abhi Offer: Get 10% Cashback on payments made via PhonePe on Jabong First time PhonePe user on Platform: Customer making transaction of a minimum value of Rs. 1000 using PhonePe account for the first time on the Platform, shall be eligible for a 10% cashback (which shall be limited upto Rs.125/-), during the Offer Period. For avoidance … Continued


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Classes for all ages and levels of experience in a beautiful bushland and harbour setting
Wednesday, May 22, 2013
Choc Ball Delights ...
3 cups of pitted dates soaked in warm water for 30 minutes, then drained
7 tbs raw organic cacao powder
3 cups almond meal
1 tsp pure vanilla (not imitation)
3 tbs orange peel grated or finely chopped
Desiccated coconut
Process dates, cacao powder, almond meal and vanilla in a food processor until well blended.
Transfer to a bowl and mix in orange peel.
Sprinkle coconut onto a plate.
Roll a tbs of mixture by hand into a ball and roll in the coconut.
Refrigerate for 1-2 hours and have a ball!! (makes approx 30 balls)
Recipe courtesy of Savour World Cuisine ... caterers for Glenda's 2010 Yoga Retreat in Byron Bay
Posted by Mosman Yoga Co-op at 10:57 AM
Labels: glenda ford
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We had the amazing opportunity to photograph our friend Marcus and his lovely bride Natalia at their wedding in Sitka, Alaska. We packed our rain gear, rain jackets, water gear for our cameras and prepared ourselves for a cool, overcast day with drizzle. Turns out, the day was amazing, sunny, and warm! Their ceremony was by Crescent Harbor and their reception in Harrigan Centennial Hall. We loved everything about this wedding and it was an honor to photograph it.
Congratulations, Marcus and Natalia! You guys are so awesome (and so was your day!!).


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August 3, 2011Read: Mark 9
"I tell you the truth, anyone who gives you a cup of water in my name because you belong to Christ, will certainly not lose his reward." --Mark 9:41
All week long, I've had this familiar thought running through my mind: He who knows us best, loves us most. I'd like to break it down, if I may.
"He who knows us." Have you ever considered that God actually knows you? If someone famous knew you, how would that make you feel? You'd likely want to do a little name-dropping now and then, huh? You know, over the course of my career, I've met some pretty big stars, but I bet not one of them can actually look up and count them.
"He who knows us best." We all have close friends, spouses, parents, and siblings. Some of us even have twins! But nobody, and I mean nobody under the sun knows you better than the Son Himself. From thoughts we haven't thought, to the ones we wish to forget, He knows us best.
"He who knows us best, loves us most." Here's the kicker. He actually loves us. He doesn't like us or tolerate us. He doesn't excuse us or simply endure us. He loves us. More than you love your kids, your husband or grandmother. Imagine?
You know, it's really not a matter of how far we'll go in this life, but more about where we'd be without Him.
I feel like name-dropping today. How 'bout you?
RECIPE OF THE WEEK: Protein-Packed Crustless Spinach Quiche
Getting enough protein is critical for building or maintaining muscle and burning more bodyfat. But in your quest to get enough of the stuff -- avid exercisers can aim for 0.75-1.0 grams of protein per pound of bodyweight per day -- do you find yourself running out of good, high-protein ideas? Try adding this one in.
"This is a crowd-pleaser every time I serve it, and it even satisfies meat lovers even though it's vegetarian!" says PrayFit contributing nutritionist Emily Ann Miller, MPH, RD. "It's great for breakfast, lunch, or dinner."
4 eggs
16 ounces low-fat cottage cheese, no salt/sodium added
1 cup shredded part-skim mozzarella cheese
1/3 cup parmesan cheese
1 teaspoon dried oregano
10 ounces frozen chopped spinach, thawed and squeezed of all excess water
Choose as many add-ins as you'd like, adding up to two cups of them: chopped bell peppers, chopped tomatoes, roasted peppers, artichokes, mushrooms
Preheat oven to 350ºF and spray a standard pie plate with cooking spray. Lightly beat eggs in a large mixing bowl. Stir in remaining ingredients. Make sure that you squeeze as much water as possible out of the spinach before adding it to the mixing bowl. Pour mixture into pie plate and bake for approximately 45-60 minutes. The quiche is done when the top is golden brown and the middle is set. Let sit approximately 10 minutes before serving. Serves 6-8.
NUTRITION FACTS: (based on 6 servings and addition of 1 cup tomatoes) 200 calories, 10 g fat (5g saturated), 276 mg sodium, 6g carbohydrate, 2g fiber, 22g protein
Emily Ann Miller, MPH, RD is a registered dietitian and works at a Washington, D.C.-based independent, nonprofit science organization, where her work is currently focused on environmental and policy solutions to obesity prevention. She also speaks to groups about health and nutrition and provides nutrition education to patients at a free medical clinic that serves low-income, uninsured adults in the D.C. area. You can view more of Emily's nutrition tips and updates by following her on Twitter, @EmilyAMillerRD.


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Thursday, February 3, 2011
Fundraising news from the Hamilton Arts Collective
Donate to the Building Fund!
The HAC needs your help to buy it's building. We've raised thousands of dollars and come a long way to purchasing our building at 5440 Harford Road but we still need your help. We need to raise an additional $1,800 to complete the downpayment.
Please consider donating to create a permanent home for the arts in Hamilton. Donors of $500 or more will be honored on the buildings commemorative founders plaque.
If you have any questions please contact Jesse at 410-804-3452 or email@example.com.


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other services
Publishing (print & web) clients
- Pre-registered clients have access to hi-res digital versions of images from the gallery
- Image formats available jpeg, tiff, nef (Nikon's own raw format)
- File delivered electronically within 4hrs
- Discounts on multiple images, negotiated on a customer by customer basis depending on the package required
- We are happy to carry out contract photo shoots for individual teams for promotion material, and/or
- attending different race meetings or track days to get action shots.
If you are a magazine or a newspaper or website, please contact us and we can supply a digital copy of the photograph for a single use fee. If you need road tests we can supply a photographer for half a day, or whole days at a specified rate.
Brands Hatch is 45 minutes away.
We have worked at most of the top circuits in the UK and Europe:
- Brands Hatch
- Silverstone
- Cadwell Park
- Mallory Park
- Oulton Park
- Snetterton
- Knockhill
- Thruxton
- Donington Park
- Castlle Coombe
- and in Europe
- Valencia, Spain
- Monza, Italy
- Nurburgring,Germany
We can be available for testing, races, or promotional photo shoots and will advise you how to get the best out of a day.
If you need us to attend a specific event please allow us time to put the relevant permissions in place to get the necessary passes to be able to go trackside or into other public restricted areas.
Contact us for more information and to discuss options.


text: "I think of my experiences there and how profoundly they changed my life," he says. "People tell kids to go overseas and learn another language. But it's not just a language you're learning. There's the whole culture, which is so much more than the language. You're learning to communicate, and there are all these unintended consequences that go with it." Learning about the Costa Rican culture and that coffee on the mountain, he says, directed his life in a way he'd not ever contemplated before—and he wouldn't have it any other way. He gives his host mom all of the credit. "It all happened only by the grace of God," he says. "It's only because my host mother made me get out there. She started dragging me all over the country— she's still strong, but very sweet. She could fast-forward in her head, and she thought, 'He's going to stay in here the whole year. I'm not going to let that happen. Not on my watch.'" Mitch Gordon is from upstate New York and lived in Taipei, Taiwan for four years before moving to San Francisco, where he currently resides. Mitch is an entrepreneur, starting a number of companies in the field of education. His most recent company, Go Overseas, helps students research, study, teach, and volunteer abroad through programs around the world. Mitch is currently completing his MBA at the University of California, Berkeley. says. "I took it for a semester in college," and after that, jumped at the chance to study Mandarin for a year in Taiwan. Getting on the plane for the first time, he says, "I remember looking at my dad as I'm about to get on the plane, saying, 'Why are you letting me do this? This is crazy!'" But he boarded the aircraft, and his world flipped upside-down. "You can't recreate that excited nervousness of living abroad for the first time," he says. "It's a great feeling in so many ways. Your senses are heightened, everything is new and amazing and fresh and exciting. I was definitely out of my element, but I embraced it and faced what ended up being a great challenge. And doing that—spending that time abroad—makes you better at anything you do for the rest of your life." He spent a year in Taiwan, returned home to finish his bachelor's degree, and went to work for a large firm as a CPA. It didn't go quite as he'd planned. "I felt like I died a little bit every day on the inside," he says. "Every day when I got to work, the bars on the spreadsheets felt like bars on a jail. Working 100 hours a week in an office with a tie on just wasn't what I wanted to do." After three years, he hit his limit and launched Reach to Teach, which helped line up U.S. teachers with schools in other countries that needed them. "The teachers wanted to make sure they ended up in really good schools, and they often didn't," he says. "The company helped them find those good schools. We're like international H.R.: we do the screening for you." X MITcH GORDON InternatIonal educator M AY + J U N E . 12 Founder and President, reach to teach and Gooverseas Mitch Gordon grew up in upstate New York with a constant feeling of wanderlust. "I always knew I wanted to travel," he says, despite only leaving the country once before he started undergraduate studies at Binghamton University. His father, who Gordon calls "really forward thinking," encouraged his son to enroll in a Chinese class his senior year of high school. The younger Gordon did, and says the class "really changed my life." "My dad pushed me to take that instead of Spanish or French or Latin that everybody else was taking," he 80 courtesy of mitch Gordon


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Laser Eye Surgery Consultations in Georgetown, ON
Which Surgery is Right For You?
There are a number of laser refractive surgeries available today; the most popular procedures are PRK and LASIK.
Although healing after PRK takes longer than LASIK due to the regrowth of the front tissue layer, one major advantage to PRK is the ability to treat patients with thinner corneas.
What to Expect After Laser Eye Surgery
Patients experience the same long-term success regardless of the type of surgery they undergo. Refractive laser eye surgery usually eliminates the need for distance vision correction; however, most patients will require glasses to improve their near vision at some point in the future. This is due to presbyopia, a condition that occurs in everyone as they age and typically begins around the age of 40.
Caring For You Before & After Surgery
In addition to referring you to an experienced and trustworthy ophthalmologist for your surgery, our team will coordinate your preliminary assessment and postoperative surgical care. During your initial consultation, our optometrists will review your candidacy and take time to address any questions or concerns you may have, ensuring you fully understand what to expect with refractive laser eye surgery.
After your surgery, our optometrists will perform five to eight follow-up examinations over a period of one year to confirm your eyes are healing properly and your vision is stable.


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Do you want to do something extra's and not just donate?
Then you can start your own fundraising. Use your creativity, passion
and qualities to support Stichting Bombo and her projects.
You can for example give a concert, organize an exhibition or get sponsored for running a marathon you name it.
You can contact us when you need any help by filling up the contact form below.
Bombo's hero's
Samosa's for Nepal
Elien en Yannick are two hero's from Belgium. Together with a group of friends they collected 1500 euro's for Stichting Bombo. That all by making and selling Samosa'sSamosa's for Nepal
Dirk the Hero!
One of my favorite Bombo Hero's is Dirk vd Wielen. I used to babysit him when he was just born and now he is taking care of children in Nepal! He was 13 when he organized his heroic act. And full of enthusiasm he put all his effort in collecting money for Bombo. What a lovely person! Below you can read his story. (Founder: Maureen vd Zandt)Dirk the Hero!
Healthy feet for Bombo
Esther van Tongerlo is an enthusiastic and friendly pedicure with her heart in the right place. She took the initiative to help Stichting Bombo in her own original way.Healthy feet for Bombo


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Today's Color Challenge:
I just love this sentiment, but the set didn't come with a fry.
How dare they exclude this vital stamp!
So I hand drew one. ~Theresa
This card was made for a woman in our church who was turning 100. I found inspiration on Pinterest for the design. The paper is by Graphic 45 from a 6 x 6 pad called Botanical Tea. I designed it on my Cricut Explore using some basic shapes and popped the tag up with some foam. The lettering was done in vinyl on my Explore using the Soiree Lettering and Art Deco cartridges with the Fabulous being welded together. I also love that the Explore will write on things and used it for the tag. This allows me to be very personal with my cards. When I went to stamp the inside, I must have had ink on my hands and put smudges on it, so I stamped a piece of the same pink cardstock as the outside tag and punched the corners with a Martha Stewart punch. It really dresses up the inside and I need to do this more often, not just when covering up a mistake. (I wrote on the card before taking the picture, so sorry for the blocking that out). ~Denise Sayers
Happy Crafting
Theresa & the CADC DT


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This Is Our Story (MMGM)
Title: This Is Our Story Author: Ashley Elston Publisher: Disney Hyperion Publication Date: 2016 Page Count: 312 (First Edition, Hardcover) Age Recommendation: 12 Five went in. Four came out. No one knows what happened that morning at River Point. Five boys went hunting. Four came back. The boys won't say who fired the shot that … More This Is Our Story (MMGM)


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Chanté is a Los Angeles-based actress and narrator who holds a Bachelors of Science degree in Speech from Northwestern University's famed theatre department. She is a proud member of the following professional acting unions: SAG-AFTRA, Actors Equity Association.
Trained in International Phonetic Alphabet (IPA) and therefore able to work up any dialect(s) needed for your project.


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WE OFFER A DELICIOUS, HEALTHY BREAKFAST, LUNCH & DINNER TUESDAY-SATURDAY and brunch sunday-monday, 9am-2pm
Experience Hippie Kitchen in New Orleans and Jefferson, LA
Eating healthy is a great way to treat your body well, and it's easy to do at Hippie Kitchen, our locally owned and operated restaurant and full-service catering company in Jefferson, LA. We specialize in farm to table cuisine highlighting organic, regionally sourced ingredients. We invite our guests in the New Orleans area to experience good food at a reasonable price. You'll feel fantastic after enjoying nutritious, seasonal food in a positive, uplifting community atmosphere.
Our seasonal menu includes casual gourmet fare that incorporates locally grown veggies, whole grains, and ethically raised fish, poultry, and meat. Try our handcrafted coffee drinks, juices, tonics, and coolers! When it comes to catering, choose from diverse breakfast menus, boxed lunches, sandwich and salad platters, small bites, sweets, and even family-style meals for a family gathering or office setting.
Whether you want a relaxing dinner for a special occasion or you need an impressive spread for a corporate meeting, we're ready to provide you with thoughtfully crafted, fresh local meals. Stop by Hippie Kitchen today—a place for people who love good, honest food.


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Le Blanc Spa & Resort Review
Going to Cancun I knew I wanted to do a review about Le Blanc, but while we were there I honestly just completely forgot to take pictures of the resort, so that's why I'm using pictures from Oyster. I snapchatted plenty, but didn't save anything. I hardly took pictures (of myself or of anything else) before I had started blogging, so I'm still getting used to remembering to do so. I did however take pictures of a very important part, the food!
The Resort
Le Blanc was truly paradise. The staff waits on you hand and foot and does their absolute best to accommodate your wants and needs. We actually got upgraded to the honeymoon suite! It had ocean view and a large hot tub Jacuzzi😍 The amenities were fantastic. They had a decent size gym with several machines; I really wanted to do aqua spinning, but unfortunately we didn't get to do any of the fitness classes because we had other things planned. The drinks were very good; they weren't strong, which is perfect for me. Below I'll share about the food and spa.
Le Blanc has 4 restaurants: Lumiere, BlancItalia, BlancAsia and BlancInternational. Surprisingly they were all delicious. The first three are dinner only spots, whereas BlancInternational has a breakfast and lunch buffet, then for dinner they have a set menu. I'm not a huge fan of buffets, but that's really because I have no self control and will continue to eat way more food than I should. During our time in Cancun, I ate as much food as I wanted to, especially due to the fact that everything was all inclusive.
Our first night we ate at BlancAsia. We had the tasting menu, so there were a few things I didn't particularly like, but overall the food was great. My favorites were the tuna and scallops.
The breakfast and lunch buffets at BlancInternational were very yummy, but I don't have many pictures of the food here, because my buffet plates were a jumbled mess. You also have the option to have the chef make you eggs/omelets for breakfast and fresh seafood on the grill during lunch. I tend to not read the descriptions and just take whatever looks good so I'm honestly not too sure what some of the things were that I ate, but there wasn't anything I didn't like. Aria loved getting an omelet made because you can add nearly anything you want and he added basically everything he could! My breakfast favorites were the plantains and something that was similar to French toast. The lunch buffet was even better than breakfast! I love seafood and there were copious amounts; my particular favorite was an octopus mixture. For dessert, I couldn't decide which to get, so I got all of them! There was probably 10 - 15 different options, but I only took one bite out of all of them since that would've been extremely fattening and a lot of sugar.😋
Apparently this is the place to go at Le Blanc; it's considered their nicest restaurant (formal attire) and a reservation is required. It was actually booked for the entire weekend, but the resort staff was the absolute best and got us in. We almost did the tasting menu since it also comes with wine pairings, but we opted against it. For one of our appetizers we ordered pequillo peppers stuffed with seafood, best stuffed pepper I've had thus far. I ordered steak for my entree and it was so tender that it melted in my mouth. The steak came with a carrot mash, which was very interesting and I couldn't decide if I liked it or not, yet I couldn't stop eating it! Overall I can see why Lumiere is the must go to restaurant at Le Blanc.
My personal favorite- all of the food was excellent. This is where we ordered the most amount of food, because nearly the entire menu sounded too good to pass up. A few things we ordered: 1. Potato and scallops gnocchi with truffled cream and mushrooms confit, 2. Cheese stuffed ravioli with lobster and roasted tomatoes cream, 3. Arugula, goat cheese and caramelized red onion salad, 4. Seafood casserole- shrimp, mussels, clams, octopus and scallops in a tomato cream sauce. Don't the descriptions sound absolutely amazing?? None of them disappointed me and my mouth is currently watering😋
Aria and I love going to spas and we've never been to one like this before. As soon as we checked in we were separated and guided to where we would spend our time before the masssge. There was a sauna, steam room, foot reflexology, hot tub jacuzzi and two small pools, one with warm water and the other with cold. Even though Aria and I weren't in the same steam room, we both agreed that this spa had the best one; it was very intense, but so refreshing. They give you a face and hair mask before going into the steam room, which I've never had done before. I prefer more of a deep tissue massage, but we did a 50 minute serenity massage with a medium touch and it was very relaxing. I felt rejuvenated after our spa appointment and I'd love to be in that steam room right about now.
If anyone is planning a trip to Cancun in the future, I would highly reccommend staying at Le Blanc Spa & Resort. If you have any questions about the resort or my trip in general, don't hesitate to ask! I hope y'all have a great Thursday!


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Pothole Request at 306 Walnut St, Brookline
Closed over 1 year ago via iPhone
request #: 18545status: Closed. Thank you for your recent request using the BrookOnline Notify Application. The pot hole has been repaired.
submitted: Thu Apr 05, 2018 09:59AM
opened: Thu Apr 05, 2018 09:59AM
closed: Tue Apr 10, 2018 09:40AM


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It all started with a phone call and the next thing we were checking weather forecasts online. We knew there was a cold front hitting Cape Town, but what exactly was the weather doing in the mountains at 2000ft or event 3000ft. After reading the snow report, we knew we had a good chance of finding snow with temperatures dropping as low as -10 degrees in the evenings and an average temperature of 2 degrees during the day.
It was on, we decided the Matroosberg Mountains would be the best place to find snow lower down the mountains, so we woke up at 5am on the 6th June, the car was packed with camera gear, food, coffee and pretty much everything we needed for an epic day out. We hit the road around 6am to make it to the Matroosberg Nature Reserve early. To our surprise we were the only car checking in for the day which meant we had the mountain all to ourselves.
It was suggested by the reserve officials that we let our tyres down to at least 1.5 bar if we were going do the 4x4 trail, and let's be honest we didn't drive all that way not to do the 4x4 trail, we were there for a real adventure. A few kilometres into the reserve the roads were less of a road and more of boulder hopping, rock sliding vertical climbs up the mountain. We pushed on and were eventually surrounded by snowy mountains with nobody else in sight. The cars thermometer blinked at 2 degrees continuously and our excitement increased with every metre gained. After about 2 hours of crawling up the mountain in 4WD low range we were welcomed by incredible 360 degree panorama views of snow covered mountains to explore all day.
We crept as close to the edge of the 1000m drop as we could and setup our spot for the day. With endless opportunities in which direction to explore, we wondered around on foot paths taking in the epicness of our surroundings. Eventually we couldn't feel our fingers or face and it was time to brew some coffee, because we all know coffee tastes better in the mountains.
We made it back to Cape Town by 6pm to call it a solid 12 hour adventure day that has definitely set the tone for this winters missions.
Gear used: Sony a7iii body, Sony Zeiss 24-70mm F4, Sony 70-200mm F2.8 OSS G
DJI Mavic Air with ND8 filter


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Rheem: Residential Hydronic Air Handler
July 16, 2012
The newly redesigned hydronic air handler, which is an element of the company's Integrated Heating & Water Heating System, incorporates a new, high-efficiency permanent magnet motor, which helps upgrade the electrical efficiency of the air handler. According to the manufacturer, powered by tankless technology, the Integrated Heating & Water Heating System provides a unique and highly efficient way to heat both the air and water in a home — while also being compatible with its air conditioners and heat pumps. When one of the company's tankless gas water heaters is matched with the hydronic air handler, hot water is circulated through the air handler and is then recirculated back to the tankless water heater, providing a soft, comfortable heat to the home while maintaining comfortable humidity levels regardless of the climate. The air handler utilizes an 11 to 100 percent combustion modulation formula for precise temperature control. It has an integrated control board with diagnostics that manage all operational functions of the unit; the control board also provides hookups for a humidifier and an electronic air cleaner.
eProduct 188


text: Avi serves as CEO & CTO for InSeal Medical Ltd. Prior to founding InSeal Medical Ltd. and its parent company E-Pacing Inc., for nine years, Avi held the position of Vice President of R&D at Remon Medical Technologies, which has previously been acquired by Boston Scientific. Before working at Remon, Avi led projects for the development of coronary and peripheral stent systems at Medtronic InStent. Avi holds a B.Sc. in Chemistry and a Ph.D. in Physical Chemistry, both from the Tel Aviv University. Avi is the principal and co-inventor of more than 50 patents and patent applications related to medical devices.Read More


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We Burned Out/
by Daniel Johnson
Whenever Helen and I spent our nights drinking fifths of rum at the marina down the street from campus, I called her Helen of Troy. She was Greek, and there were all those ships, and in that naked moonlight her olive body looked as if some hunchbacked old Athenian sculptor had spent his lifetime casting its mold. Sailboats rocked against the pier and the warped wood of the docks would cry out. I told her they were made restless by her beauty, the boats. She knew it was just the ocean and that I was drunk. She would tell me to stop it, but in that way that meant she wasn't really sure whether or not she wanted me to.
Helen wore nautical outfits a lot: anchor belt-buckles, lighthouse earrings, navy and white striped blouses. Her family was rich and we went to school on an island. She carried a miniature ceramic Tragic mask on her car keys that dangled out the back pocket of her brass-buttoned sailor shorts. When I was with her, I usually wore an undershirt and an unwashed pair of Levis with one of those mini pockets-within-a-pocket, where I stored two Ativan in case I had an episode during the day.
Most of those nights, we finished our fifths and tossed the empties into the Atlantic. They'd bob there and reflect coins of moonlight on the waves and sails and sometimes on our faces until they sank to the shallows. We would walk back up the hill towards campus and I'd rest one hand against the almost unnoticeable impression of the pills in the denim. I made it look like I was being smooth: just a thumb hooked in a beltloop. In my other hand, I'd hold Helen's. The streetlights above us were orange and globular, like old diver's helmets atop stakes of black iron.
She always did this thing where she would walk slightly in front of me and not look back. I didn't mind. I'd watch the backs of her legs and think about how all I wanted was to feel them against my body every night, the way I could feel the pills. About halfway up the hill, I would know I needed to take them because the walk was steep and the rum made my heart roll.
Part of me thought the reason Helen never came home with me after the marina was because, by the time we reached campus and I asked her to come to bed, my breath smelled rotten and synthetic from the Ativan. Sometimes they scraped against the roof of my mouth for the rest of the walk home before they'd swallow down. I imagined they left trails of residue, like long white cuts, along the back of my throat.
It was always the absence of something that triggered my anxiety. It was the silence that came when my roommate would go home for the weekend and leave me alone in our fluorescent dorm room without the box fan he used for white noise. It was the nights when I wasn't surrounded by bar lights that blinked arrythmically, or by crowds of people in rave outfits with drinks the color of glow-sticks. It was whenever I wasn't with Helen, or knew I wasn't going to be with Helen, which was quite a lot. Helen didn't like to stay the night.
We almost only saw each other after dark and, other than the nights at the marina, strictly behind the closed doors of my bedroom, which I found sort of sad. In daylight, the single-hung windows of my dorm would catch the sun from all its angles. The few times we spent afternoons together, Helen would wear her thinnest, whitest dresses and dance in the swaths of sunshine about my floor. She would stand over my knee as I sat on the edge of my bed and lift the hems up and hold them with her teeth. She'd have me touch her. Often, she reminded me that her name, in Greek, meant bright light, or flash, or something.
Otherwise, she'd come over after her evening classes and we'd watch Baz Luhrmann films and make love on my twin bed in the underwater lighting, the swimming blue shadows from the tube TV on my hutch. After we were done, I'd roll over into the crook of the wall and listen to my heart palpitate while she checked her phone. I'd fear that I had just voided some essential part of myself. Sometimes I'd be okay. There were others when I'd trip into a regiment of deep breathing exercises I'd learned from a Youtube video of a poorly animated blue butterfly that fluttered its wings in time with my deep breaths against a backdrop of green hills and silvery rays from an invisible sun.
When that happened, Helen would do this other thing where she'd hover her open mouth over mine. It looked like she was trying to kiss me really hard, or swallow me whole and hide me inside her belly. But she always left a space between our lips where the hot air would flatten out and cool. I'd hear these soft clicks against her teeth, like there were little crystals in my breath that sparked cold along the faces of her molars, which were perfectly aligned because she kept them in her retainers whenever she was alone. The breathing exercises only worked, really, when she did that other thing.
Each night, before she got dressed and went home, we'd watch the rusted reflections of the city below us shimmer on the ocean from the concrete slab of my windowsill.
"We could be good together," I'd tell her.
The sill was cold against our bare thighs, so most times Helen would climb atop my lap and lounge into me. She'd let the back of her hand fall against the glass. It would leave blurred knuckleprints there, streaked along the pane. I'd wipe them clean whenever she didn't text me back.
"It looks like it's on fire," she'd say. "The water—isn't it something?"


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Scarifier for home use
Practical and manoeuvrable scarifier for home use in gardens of up to 1000 m²; this is the perfect tool for use with lawnmowers for turf scarification in preparation for early-season grass cutting, getting rid of weeds, moss and thatch and ensuring better aeration of the lawn. Also useful before sowing or fertilizer spreading for improved soil penetration.
A new product in the Efco range, the Efco AG40-S50 Lawn Aerator Scarfier is a high quality machine suitable for the most demanding heavy domestic user or even for simple commercial use. Fitted withe the best quality Subaru OHC 4-stroke engine and running on double ball bearing mounted plastic wheels, the Efco AG40-S50 Lawn Scarfier is sure to provide years of reliable easy use. Special quality Hardened, fixed steel blades (40cm working Size) rotate on extra large bearing mountings which are fitted inside a reinforced steel deck, making use on the toughest soil conditions a simple task. Working height is easily adjusted with a central lever equipped with a built in memory, just in case you want to return to your previous working height. For compact storage the handlebars will fold down at the turn of a lever and a fabric collector is supplied for when you want to tidy up after yourself.
Efco AG 50 H 60 the sort of power and build-quality that are essential for professional grounds-keepers, the high-specification Efco AG40-R45 will take challenging lawn-care and sports-pitch maintenance applications in its stride.Making it tick is a 5.5hp (163cc) Honda GX160 engine; a four-stroke, overhead-valve type power-pack that features a forged-steel crankshaft and a dual-element air-filter for durability; precision-engineered components for reduced noise and vibration; and an optimised valve overlap for superior fuel-efficiency. Automatic decompression means starting is almost effort-free.The Efco AG50-H60 Professional Petrol Lawn Scarifier is equipped with a set of free-swinging, hardened-steel blades that are mounted on oversized ball-bearings so as to ensure season-after-season of unfailing reliability in the face of intensive use (the blades give an expansive 50cm working-width).It's built around a reinforced steel deck, so any accidental impact it might encounter won't prove a problem; and it runs on ball-bearing mounted wheels that won't stiffen-up over time, and which ensure smooth operation on rough ground.Additional features include convenient single-lever blade-height adjustment; and space-saving fold-down handlebars.


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The corsair neutron 960gb internal 2 5 inch looks like an excellent internal solid state drive for us but other data storage review maybe says otherwise. With quad-core ssd controller and at under $550 price youd expect it to be quite a deal.
>> Check Currently Price HERE! <<
As an excellent data storage, corsair neutron xt series is an ultra-high performance ssd engineered to meet the most sophisticated demands and under wide range of different workloads. it is loaded with several features crossing from enterprise segment and bridges the gap between needs of an enthusiasts looking for maximum performance and demands of professionals requiring consistency and reliability. in particular, corsair neutron xt is an ideal ssd for hardcore pc gamers, design professionals and 4k video content creators, who demand the best in class performance from a solid-state drive.
customer service / tech support: 1-888-222-4346 opt. 1
This corsair neutron xt 960gb sata iii mlc 7mm internal solid state drive 2.5-inch due for anyone who are looking for internal solid state drive with quad-core ssd controller. exceptional transfer speeds. consistent performance. end-to-end data path protection. low power consumption. power loss protection. enhanced error correction. static and dynamic wear-leveling.
It most comfortable and better to purchase this data storage since get an opportunity to hear how real buyers felt about purchasing this internal solid state drives. Reviews by individuals who have take on board this corsair neutron 960gb internal 2 5 inch are valuable explanation to make choices. At the time of publishing this corsair neutron 960gb internal 2 5 inch review, there were more than 32 reviews on this web. Most of the reviews were greatly pleased and we give rating 4 from 5 for this corsair neutron xt 960gb sata iii mlc 7mm internal solid state drive 2.5-inch.


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List it for Free on The Nation and find a buyer or tenant!List your Townhouse
The average price per square meter for a Townhouse For Sale in Paklok is ฿80,628, which is 40% below the average price per square meter in Phuket that is ฿113,169.
Paklok is a large, undeveloped and peaceful area on the east side of Phuket. It's covered by rubber tree plantations and mangrove forests. When the tide is low, local fishermen will walk out on the mud amongst the mangrove trees. As the tide returns, the mangroves get covered in water again. Paklok also has a few nice sandy beaches found near the mangroves, used by locals when there is good weather and the right tide.


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Children in Need and The Blogmistress
Every year this incredible event raises millions of pounds for children in need throughout the UK and beyond. And of course it is never enough – perhaps one day it will and all children will be safe and well and cared for, but until then the UK will continue to raise the bar and give more, even through more austere times. It swells the heart, and also makes me sob to see the courage of those children. The Team Rickshaw challenge has especially touched me this year and so to do my small part I am giving my time in return for a donation to Children in Need.
To have a task actioned for you, send details to email@example.com and I'll let you know if I can actually help or not (or advise you). Then you donate what you can. The intention is to keep it simple, and I will work through the weekend if needs be.
My Facebook page has more details and will be updated through the day.
Already I have a couple of tasks and inspired someone else to do something similar; my face may ache by the end of the day from smiling so much.
Thank you.
Renaming Your "Comments" Title in Genesis
I happened across a retweet of a post written earlier this year by my friend and client, Suze, which considered how we ask for readers' feedback, questions, thoughts, comments…
For instance, here on the Blogmistress blog, you're invited to "Leave a Reply" – hardly ideal so that's added to the site revamp list.
And on Suze's How to Write Better site it just
says said "Comments". Far too cold for the style of Suze's blog. So I'm going to surprise her by changing this to something far better suited.
As her site is created using a StudioPress Genesis theme this will not be a terrible task and while I can delve into the Loop and code and things, there is a plugin that will offer a great variety of options for the commenting function in any of the Genesis themes. Wonderful. Indeed while I do like the way Genesis is coded and am not afraid to tweak things to suit, sometimes a plugin is just fine for the task and is unlikely to use up a load of space.
So with such themes I will do a quick search within the Plugins section of the Dashboard, this time for Genesis Comments – and lo, NickTheGeek had created just the tool a few years ago – Genesis Simple Comments. He's not updated things for a couple of years and this would normally put me off, but in this instance we're not doing anything particularly difficult and Nick is a full-on Genesis geek, so it's worth giving it a go (and indeed I may offer to check it out for him).
Anyway – installing this plugin offers the options to change the titles and wording for just about all comment related text. I'll do a quick video later and add that here for you.
Thanks Nick for the plugin, and Suze for the inspiration.
I wonder how long before she notices 😉
Quickie: Adding a Search option to your WordPress website / blog
In the Blogmistress Facebook group we were asked about adding a search option to a WordPress website. And while there are plenty of plugins that offer the various search functions you might want, the simplest thing is to add the search option included in your WordPress already, then test that out – if it does the job well, then you've no need to add anything further. Here's how:
- Go to Appearance, Widgets
- Select, drag and drop the Search widget into your sidebar or widget area
- Test
It is that simple. Do have a good try at finding things to be sure this search option is good enough for your site. If it's not up to what you need, that's the time to have a look at the plugin options and see if what you want is there – as ever, when looking for a plugin, look at the details and go for those that are tended to – kept up-to-date and the support posts on the WordPress plugin page monitored and ideally resolved.
If you get stuck, let me know…
Where to get images for your WordPress blog posts
Many of us need and want to know where to find and how to add great images to our WordPress blog posts and pages.
Pictures can take a add polish to good blog, making it a great blog; using quality images is important. Simply using images from a Google image search is not a good idea (unless you want to ensure the copyright situation for the images you find and want to use), nor is copy/pasting scrappy-looking clipart from Word, etc.
There are a many ways to include images legally and we make frequent use of the following:
Fotolia for when you want a polished, specifically created image – yes, it costs a from £1.20 for each image, but you choose exactly what you want and know you are legally allowed to use the image. The downside of Fotolia is that many images look staged and obviously "stock" images (not created specifically for you).
Photopin offers images shared freely through Flickr by the photographers. You need to include the credit details for the photographer – this information and link is provided for you to copy/paste to your post or page. You can read how to use Photopin for your WordPress blog here.
And Stock.xchng is still worth a browse for good no-charge, royalty-free photographs.
Just don't, whatever you do, use images you find in the Google image search – that is not a good idea unless you want to track down and request permission.
There a few plugins that will help you find images too – have a browse if you like (search within Plugins, Add New) but be aware of any links that may need to be included or that your website doesn't slow down as a result.
This should cover most of your needs, however we'll take a look at options to create images and how to resize them. And if you use a good image source, please share…
One other thing – be careful not to spend too much time trying to find the perfect image – before you know it, half an hour has passed in enjoying wonderful images!
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This Friday, October 26th, is National Pink Hejab day!
Get your pink ready, hibab or ribbon or scarf!
-Courtesy of Muslimah Media Watch
This Friday, October 26th, is National Pink Hejab day!
Posted by lilith attack at 2:01 PM
i´m in Germany / Munich and i wore this pink hijab today :))
Yay! I wore a pink scarf today and one person did ask about it so I was given the opportunity to talk about Pink Hijab day! She looked at me a little strangely, because I am not muslim. But I was proud to be supportive and always willing to show pink support for breast cancer. I can't wait to check out your blog, it looks beautiful from a glance!


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- 08-Oct-2019 to 06-Dec-2019 (PST)
- Victoria
- Victoria, BC, CAN
- Hourly
- Full Time
Securiguard maintains a highly trained Canine (K-9) division that is certified in narcotic and explosive detection as well as canine protection patrols. Developed for high-risk situations, Securiguard's K-9 division was the first private patrol certified by the RCMP.
The division has since been expanded to include foot patrols for customer sites, as well as providing explosives, weapons and narcotics detection services. It has been used in crowd control situation for major events. The use of a dog in conjunction with trained security guards adds a high level of deterrence and peace of mind for our clients.
Our K-9 teams are geared for rapid response resourcing to assist our clients with unique challenges in camps, airports, cruise ships, trucking and shipping environments as well as the physical protection of assets such as remote parking lots and commercial properties.
Currently we are recruiting for K9 Handlers to join our team of certified professionals.
Job Duties:
- Actively attend all sites required with your K9 partner – patrol premises with a focus on effective deterrence and removal of any unauthorized persons on site
- Provide excellent customer service with a continued focus on client and community relations
- Care for the designated K9 as per provincial regulations
- Assist and respond to any calls by the K9 Operations Manager for additional service as required
- Conduct Access Control
- Interior and exterior patrols as required, including but not restricted to parking lots, stairwells, hallways, common area facilities
- Providing excellent customer services
- Coordinating and liaising with police and other emergency service providers as required
- Providing detailed statements including occurrence, incident and patrol reports as required
- Reporting and documenting any safety hazards to the Operations Managers
- Explosive or narcotics detection
- Valid BC Security License
- Valid class 5 drivers license with a clean Drivers Abstract
- The ability to work outside during all weather conditions
- Excellent communication skills (Both Verbal and Written)
- Strong attention to detail
- Desire and passion to work with dogs
- Commitment to a 4 month K9 Training Program
- Safe vehicle to transport a K9
- The ability to take care of K9 after hours and live in a friendly environment for a dog
- Fenced yard for a K9
Employee Perks:
- Paid Overtime
- Handler Allowance
- All dog Expenses Paid
- Benefits from day one
- Exciting high profile sites
Additional Information:
- House inspection will be required by a K9 Operations Manager
- Cost of Food for K9 Dogs is covered by Securiguard Services


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We start with a 2-hour scenic drive to Coromandel to check out the film location from the scenes in the Chronicles of Narnia movie. You will get plenty of opportunities to take photos here. There is a low-medium level difficulty hike which is approximately 40-50 minutes to get to the film location. Trust me, it's worth it!
Next up, prepare to be amazed at this golden sand beach where you can dig your own spa pool in the sand for you to enjoy!
Check out their feedback on Booking website – only positive feedback and praises. The place is very well kept, friendly staff, very comfy and relaxing place to stay at.
We cross the road from your accommodation to the famous Karangahake Gorge where you can choose to do the Karangahake Tunnel Walk or have a picnic by the riverside.
Sounds yucky but this is an amazing place to see these creatures that live in this cave for many years.
Home of New Zealand's famous L&P Drink. Photo opportunity next to the big L&P bottle.
Note: A minimum number of 2 participants are required in order for the Tour to go ahead.


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- Work was killer today nothin new as usual
- went wally world saw a cd player for my car iliked
- igot a mini gov project due tuesday ill do that tomorrow when iget home
- iReally need to finish filling out my financial aid
- iReally hate reading for english...what a dragggggg
- im glad tomorrow is a Bday doe...A Days are a hassle for reel
- iChilled wit my cuzzos Chris & Corey today too hilarious hahahaha
- Black History month is about to come to an end this week
- icant wait for the remaining members of goon squad to return soon!
- but my Birthday is almost a month away now KOOLNESS!
iWant this bad boy doe
this movie came on today and ihavent seen it since iwas a kid...gosh time flies


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This stunning, contemporary residence offers the perfect Resort Lifestyle where every detail has been carefully considered for today's busy family. The impressive, light filled open-plan living & dining areas with fabulous stone & stainless steel kitchen all flow seamlessly through to a magnificent covered al-fresco entertaining area equipped with outdoor kitchen & pizza oven. All of this opens to a North facing landscaped oasis with pool, in-ground spa and private sun soaked spaces to relax and unwind. The upper level encompasses four double bedrooms plus a further casual living/media room essential for family living. The master suite is complete with walk in robe and stunning ensuite bathroom. There is a double garage with internal access and loads of storage. This superbly presented home is located only a short level stroll from schools, shops, restaurants and transport and has everything your family could possibly wish for and more! Agent's interest.
Council $444.00 p/q, Water $171.98 p/q
|R&H Suburb Summary
|Number of sales
|Average Price
|Median Price
|Median Rental Price
|$1,200 p.w.
|Change in Rental Rate (5yr)
|0 %
|R&H Suburb Summary
|Number of sales
|Average Price
113 Edinburgh Road, Castlecrag,
New South Wales, 2068


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Escape to Bournemouth's golden coast for a delightful 4 star stay at The Cumberland Hotel, a modern and stylish sea-front property. Stays here include coffee and cake on arrival, a delicious dinner on the first evening and breakfast.
What's included?
At a glance
Good to know
Our saving of 25% highlighted on this offer is calculated based on rates displayed on the hotels website, compared to the Greatlittlebreaks selling price. An example of our discount throughout July is:
On 24/07/2019, this package totals £358.80 to include a two night stay in a Comfort Double Room with breakfast and added value extras, as listed above.
Based on the Greatlittlebreaks price you will save 25%. Our discount was checked on 13/06/2019.
of our customers would go back
One of our team has been to this hotel and we are pleased to say it meets our high standards.
Price based on two adults sharing a room unless otherwise stated.
Price Promise
You can always feel confident when you book with Great Little Breaks whether it's online or through our call centre. If you find the same deal cheaper elsewhere, once you've made your booking with Great Little Breaks, we will refund you the difference.
© Great Little Breaks is part of Hotelshop UK Ltd | ABTA Registered L8766
© 2019 Hotelshop UK Ltd | Company Registration No: 3812146 - Registered in England and Wales. Brine Well House, Tower Hill, Droitwich Spa, Worcs WR9 8BY
2019 Great Little Breaks is part of Hotelshop UK Ltd | ABTA Registered L8766
created by bluebox


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Contact Paul Today!Don't suffer in a job you hate. Do the work and create your dream job!
Contact Paul today and learn about the steps and process to get everything you want out of your career and potential dream job.
Contact Us and Start Your Search for Your Dream Job Today!


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by Maxx Biker, on
Those of you who at seeing BMW's tablecloth trick said frenetically that neither the S1000RR nor any other superbike could ever do that no matter the acceleration times, will surely find reward in this video. Bike Magazine have taken the exact same bike and used a much smaller table only to demonstrate how the trick just isn't possible at large scale.
Also see the Vespa tablecloth trick.
Source: masmoto
1 comments:
(1023) posted on 07.26.2010
Haha, failed! But that's a nice attempt.


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The replica watches are easy to acquire while the working procedure of it would remain same like the ones that requires a high payment. You may prefer to get the item that works absolutely like an original one but the price does not put a burden to you like that. However, as the price ranges are not so high, the replica watches are likely to make troubles for the people. rolex replica Therefore one should take the watches after checking them thoroughly.
The machinery of the watch should be properly checked before buying because the systems may create trouble after some times. However, finding the pros and cons before booking the watch would be a good option and that can make both the counterparts happy.
The main advantage of buying these watches is itsaffordable price. They are manufactured in such a way that even the experts find it very difficult to tell that it is a replica watch. Usually Rolex, Cartier and Bvlgari replicas are manufactured nowadays in different parts of the world.One can buy a good quality replica watch either through an online store or at a local store. You have to be very careful while purchasing a replica watch. You must have prior knowledge about the product that you are purchasing and check online about the different types of replica watches and its price difference. Whether you buy online or from a store make sure about the guarantee and return policy, the shipping policy and genuienty of the website or the store from where you are purchasing. All customer reviews of the product and website reviews from where you are purchasing must be checked.Do not give any personal information while buying a watch online. rolex swiss replica quartz Make sure you are aware of all the term and conditions and the product has a clear picture of itself.


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For companies or groups looking to do something interesting as a team-bonding or a thank you, Scrumptious Fudge offers organized "socials" where a variety of flavors are offered for employees to sample and enjoy. Organizers determine how much fudge is needed based on the estimated number of attendees, and we provide the fudge and set up in a convenient area at the company or group location.
It's a different option than cookies, cupcakes, or other sweets often brought in by companies. The setup can be basic, simply providing fudge packages, plasticware, and plates — or we can set up a little more ornate with table coverings and offering refreshments to go with the fudge.
The pricing depends on the amount of fudge needed and any other additional enhancements to make the event more special for your group or company.
Please contact us to inquire about options and availability.


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april, 2019
This is a repeating event5th may 2019 12:00 pm
07apr12:00 pm4:00 pmSavage Garden Rooftop Dog Brunch12:00 pm - 4:00 pm Savage Garden, Double Tree by Hilton, Floor 12, 7 Pepys St, London EC3N 4AF Event Organized By: Savage Garden
Event Details
One of London's best rooftop bars, Savage Garden, has gone barking mad by introducing the special 'Savage Garden Rooftop Dog Brunch' on the first and third Sunday of every month
Event Details
One of London's best rooftop bars, Savage Garden, has gone barking mad by introducing the special 'Savage Garden Rooftop Dog Brunch' on the first and third Sunday of every month due to popular demand.
*** Updated, read our review of the Savage Garden Dog Brunch here ***
Dubbed as London's wildest sky-high destination, Savage Garden, brings decadent décor, jaw-dropping views, dramatic cocktails and savage menus to Tower Hill. Located atop the DoubleTree by Hilton, the ethos is focused on the unexpected. Two terraces provide 360-degree views of the London skyline including The Shard, Tower of London, The Gherkin and St. Paul's Cathedral.
Guests have a wide variety of savagely good brunch dishes to choose from off the a la carte menu that is as far removed from traditional brunch items as possible. Panko chicken cutlet, bacon and radish salad, cranberry, caper, sriracha mayo and a sunny-side fried egg, as well as bourbon-glazed beef short rib, charred sourdough and poached eggs', are tipped to be some of the favourites.
Cocktails are abundant, with bloody mary 'red snappers' and zesty mimosas all making an appearance.
Bring your pooch to this sky-high destination and enjoy a day out with your best friend. This brunch is definitely not going to the dogs.
And if you don't have four legs, you can still come and enjoy the usual Play Brunch that is on offer and make some new furry friends.
The Savage Garden Rooftop Dog Brunch takes place from 12pm until 4pm monthly on the first and third Sunday of the month with reservations at 12pm, 1pm or 2pm. To reserve your table visit www.savagegarden.co.uk or call 020 7709 1043.
Event description: Savage Garden | Event photo: Rachel Oates for Hiro and Wolf, sponsors of the inaugural Savage Garden Rooftop Dog Brunch
(Sunday) 12:00 pm - 4:00 pm
Savage Garden
Double Tree by Hilton, Floor 12, 7 Pepys St, London EC3N 4AF
Future Event Times in this Repeating Event Series
5th may 2019 12:00 pm - 5th may 2019 4:00 pm2nd june 2019 12:00 pm - 2nd june 2019 4:00 pm7th july 2019 12:00 pm - 7th july 2019 4:00 pm21st july 2019 12:00 pm - 21st july 2019 4:00 pm4th august 2019 12:00 pm - 4th august 2019 4:00 pm18th august 2019 12:00 pm - 18th august 2019 4:00 pm1st september 2019 12:00 pm - 1st september 2019 4:00 pm15th september 2019 12:00 pm - 15th september 2019 4:00 pm6th october 2019 12:00 pm - 6th october 2019 4:00 pm20th october 2019 12:00 pm - 20th october 2019 4:00 pm
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Covers and Mats
Even sitting in the driveway your car's finish is susceptible to the sun's damaging rays. Protect your car's paintjob with a car cover to shield it from the fading effects of the sun's UV rays. Floor mats for your car help protect your car's interior from high traffic footfall. Dirt and mud are shielded from getting ground down into the fibres making it much easier to clean your car.