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Genetics of PFIC: Current Status and Implications
By Laura Bull, Ph.D.
Professor Liver Center Laboratory, Department of Medicine, and Institute for Human Genetics University of California San Francisco
I am writing this summary in the spring of 2018. My Ph.D. training was in human genetics, and in the 25 years since then, I have performed research at the intersection of genetics and cholestatic liver disease. My work has focused on understanding the genetic factors contributing to inherited cholestasis, including PFIC and related diagnoses such as BRIC (benign recurrent intrahepatic cholestasis) and hypercholanemia, as well as ICP (intrahepatic cholestasis of pregnancy). I have also performed genetic and physiologic research using a mouse model of PFIC1, also called FIC1, or ATP8B1, deficiency.
In this article, I will try to provide an overview of our current understanding of the genetics of PFIC, based upon our work and that of colleagues in the field. I will also indicate some of what still remains unknown.
PFIC is often divided into 2 broad categories: 'Low-γGT PFIC,' in which serum activity of gamma-glutamyltranspeptidase is usually low or normal, and 'high-γGT PFIC,' in which the activity is above normal. In reality, occasional patients have intermediate levels and can be hard to categorize according to this criterion, and every once in a while, we find a patient whose γGT doesn't fit what was expected, based on genetic findings. Nevertheless, γGT can be a useful way to subclassify forms of PFIC.
One other point to note- while this article focuses on patients with the clinical diagnosis of PFIC, the reality is that different patients can have mutations in the same gene, but have cholestatic disease of varying severity- for example, some patients with mutation in FIC1 have PFIC, while others are diagnosed with BRIC, or appear to have a condition that is intermediate between these 2 conditions. This variation in severity of disease between patients with mutation in the same gene is at least partly explained by differing effects of mutations. Some mutations more or less completely prevent function of the protein encoded by the mutated gene, while other mutations may impair, but not completely prevent, protein function.
Most PFIC patients in whom genetic mutations have been identified appear to have autosomal recessive disease. This means that they develop PFIC because both copies of a single gene important for liver function- one inherited from mom and the other from dad- carry disease-causing mutations. All of the forms of PFIC discussed below have this type of inheritance, unless otherwise mentioned. I will briefly describe the different 'PFIC genes' that have been identified to date.
(Note: in human genetics, gene names are shown in italics, while protein names are indicated in regular text. Especially since the commonly used names for particular genes are sometimes different from the typically used names for the proteins they encode, this can be confusing. I've tried to use the most frequently employed names for the genes and proteins discussed below.)
Some people with low-γGT PFIC carry mutations in ATP8B1, the gene which encodes the FIC1 protein (for Familial Intrahepatic Cholestasis 1, as it was the 1st PFIC gene discovered). FIC1 is expressed in the liver, but is also expressed in many other places in the body. FIC1 deficiency is often considered a 'syndrome' (a condition in which multiple organ systems are directly impacted by the loss of protein function), rather than simply a liver disease. For example, FIC1 is expressed in the intestine, pancreas, and inner ear, and FIC1 patients are more prone to diarrhea, pancreatic insufficiency, pancreatitis, and hearing loss than are most people with cholestasis.
When FIC1 deficiency was first discovered as a cause of PFIC, we didn't know what the FIC1 protein does. Accumulating evidence now indicates that it is a 'phospholipid flippase' that helps maintain the proper distribution of lipids within cell membranes. The precise ways through which loss of FIC1 function leads to cholestasis aren't certain, although there are several ideas with at least some supporting evidence. For example, incorrect distribution of lipids in liver cell membranes may make the liver cells more vulnerable to damage by bile acids, and may cause some membrane proteins important for normal bile acid transport to have impaired function. FIC1 function may also be important for movement of vesicles within cells; such movement is important for a variety of cellular processes.
The most common genetic form of low-γGT PFIC is caused by mutations in ABCB11, the gene which encodes the BSEP protein (bile salt export protein). BSEP is expressed only in the liver, and transports bile acids out of the liver. When BSEP function is lost or impaired, bile acids accumulate in the liver, causing cholestasis and often, liver inflammation and damage. Depending on the nature of the BSEP mutation(s) that a patient has, PFIC caused by BSEP deficiency may progress rapidly, or more slowly.
Mutations in ABCB4, which encodes the MDR3 protein, can cause a high-γGT form of PFIC. MDR3 protein helps move PC (phosphatidylcholine) from within liver cells into the part of the liver where bile is formed. PC helps form micelles with bile acids in bile. In these micelles, bile acids are surrounded by lipids, and so are not able to damage the nearby liver cells. When there is not enough PC in bile, the bile acids in bile are able to damage liver cells. Patients with PFIC caused by MDR3 deficiency usually have mutations on both copies of the gene. However, unlike in FIC1 and BSEP deficiencies, people with only one mutated copy of MDR3 are known to sometimes develop liver disease due to partial MDR3 deficiency; in such cases, the liver disease may progress slowly over the life of the individual, and not be noticed until it is advanced.
The TJP2 protein (Tight Junction Protein 2, sometimes called ZO2) plays a role in structures called 'tight junctions.' Tight junctions occur where cells meet, and help to control what molecules are able to pass between cells, as well as separating different parts of the cell membrane from each other. Such junctions are important throughout the body, and TJP2 is expressed in many different tissues. PFIC due to TJP2 deficiency does not always fit perfectly into the 'low-γGT' versus 'high-γGT' categorization. The γGT tends to be close to normal- i.e. most similar to that in low-γGT PFIC, but sometimes a bit higher.
Given that TJP2 is present throughout the body, we might expect that TJP2 deficiency, like FIC1 deficiency, could be a syndrome, affecting more than just the liver. However, only a small number of patients with PFIC caused by TJP2 mutation have been studied so far, so we don't yet have a firm understanding of what manifestations, other than liver disease and its consequences, TJP2 deficiency patients may have. So far, information indicates that TJP2 deficiency patients may have an increased risk of some respiratory and neurological conditions.
A seemingly especially rare genetic form of low-γGT PFIC was recently identified. This form of PFIC is caused by mutation in NR1H4, which encodes the FXR (the Farnesoid X Receptor) protein. The FXR protein is known as a nuclear receptor and transcription factor. This means it plays an important role in controlling the expression of genes. FXR is important in regulation of bile acid metabolism in the liver and intestine, as well as in other aspects of metabolism. Patients with PFIC due to FXR deficiency seem to develop rapidly progressing liver disease very early in infancy. Only 4 patients have been reported so far, but more will likely be identified over time. Then, we will be able to better understand the full spectrum of manifestations of this form of PFIC.
MYO5B/MYO5B (No PFIC number in use)
Genetic mutations in MYO5B (Myosin 5B) were found some years ago to be responsible for some cases of a predominantly intestinal disorder called microvillus inclusion disease. It was noticed, that some patients with mutations in this gene had cholestasis as well as intestinal disease. Just in 2017, however, a number of patients with mutations in MYO5B were reported who have low-γGT cholestasis, without significant intestinal disease. We aren't yet sure why some patients with mutations in this gene have intestinal disease without liver disease, others have liver disease only, and some have both. MYO5B is expressed in multiple parts of the body, and is involved in maintaining proper functioning of cell membranes and helping to move proteins, such as BSEP, to where they are needed in the cell membrane. Some patients with cholestasis due to MYO5B deficiency have progressive liver disease, while others have it only intermittently. Even in the patients with progressive liver disease, progression usually seems slower than in patients with other genetic forms of PFIC.
Although many PFIC patients have mutation in one of the genes mentioned above, there are still PFIC patients in whom we do not find mutations in any of these genes. Genetic studies are underway, in my lab and other places as well, to try to identify genetic factors contributing to PFIC in such patients. There are several reasons why the identification of the genetic cause of PFIC may be more difficult in some patients. For example, it may be the case that there are a number of very rare genetic forms of PFIC, due to mutations in other genes, that haven't yet been figured out; usually, the rarer a genetic condition is, the harder it is to identify the relevant disease gene. It may also be the case that some PFIC patients carry mutation in more than one gene, which makes determining the genetic cause of their condition more difficult. Also, some patients may have mutations that are very hard to detect with usual genetic testing methods, and for some genetic changes that are found, it is difficult to tell if they are likely to cause disease or are just rare genetic variation without an important role in causing disease. Also, occasionally, a patient diagnosed with PFIC may turn out to have mutation in another gene implicated in a different form of liver disease; the genetic cause of disease in cases like this may be identified with genetic testing that looks at large panels of genes important for the liver, or by approaches such as whole-exome sequencing (in which the aim is to sequence all of the protein-coding sequence in our DNA) or whole-genome sequencing.


text: At the time of writing this recipe we're only a few weeks away from Christmas Day. Every year I seem to have more jobs to get done and this is the time of year that I'm likely to be more relaxed than I should be about my food. So to combat that I've batch cooked a few things for the freezer including this recipe. I have tasty, lean dishes to fall back on when time is short.

subset: commoncrawl


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Any idea why? Appreciate the help!
Any idea why? Appreciate the help!
I don't know when your status changed to contributor, but if you have been one for a while and now you can't see photos, delete your SMC cookies, restart your browser and then log in to SMC with your user name and password.
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Captain USN(Ret)
My advice, comments and suggestions are free, but it costs money to run the site. If you found something of value here please give a little something back by becoming a contributor! Please Contribute


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"The Lord is My Light"/
We end our first season the way it began, with a setting of a Psalm text! Join cohosts Zack Stachowski and Matt Reichert as they speak with composer Christopher Walker about his setting of Psalm 27. They discuss the sometimes not-so-helpful structure of responsorial Psalms, the clash of popular music culture and liturgical music culture regarding composer celebrity status, the importance of humility, and more.
So, please open your hymnal to "The Lord is My Light."
Episode links
For more information about Christopher Walker and his other compositions, visit his composer page at OCP. You can find additional information at his personal website: www.christopherwalker.com.
You can purchase a copy of the score and a copy of the song recording from OCP. You can also purchase the other song recordings you heard in the episode: "O God, You Search Me" (Bernadette Farrell), "Keep Me, Lord" (John Bell), and "Hail Mary, Full of Grace" (Christopher Walker).
Don't forget to "subscribe" so you'll never miss an episode!
All content of this podcast is property of Open Your Hymnal or its content suppliers and is protected by United States and international copyright laws. For information about the podcast and its use, please contact us.


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Women's Version
Difficulty: 3 (1=Least, 5=Most)Clearance required*
Poignant, most popular song from WWII. Heartfelt arrangement and one of Jim's personal favorites. This was arranged and dedicated to Judy's mother during her final days.
*Clearance instructions. easysonglicensing.com or call 800-360-5192.
Other arrangements: Men's
Sample images are for your evaluation. Your purchased arrangement will, of course, will be complete.
(Note: You will not receive a digital, printable copy of the music if you purchase additional copies. This add-on legally allows you to make reproductions of the full arrangement you are purchasing or already own.)
If your group is larger than a quartet, each additional copy is $2.00
In that case, deduct 4 from your total number in your group(so you don't pay for the included copies)
Then, enter that quantity below
Be sure to click the "Add More Copies to Cart" button
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WELCOME To SAMBUXA NYC!
At SAMBUXA NYC, we individually hand wrap sambuxas with diverse fillings from sweet to savory. "Taste is in the fold." Our Sambuxas have multiple thin layers, adding to the crisp. A unique blend of East African, Caribbean and Middle Eastern heritage, inspires fresh, tasty fillings. The Sambuxas, commonly known as Samosas are usually served when guests visit (meaning constantly) or at weddings and holiday celebrations. Our work is influenced by the generations of women and their hosting of catered events that left guests talking for days.
Every culture has it's Sambuxa! Whether you want to call it Samosa, Sambusa, Sambusak, Fayter, Patties, Empanada, Meat pie, Dimpling, Piroshki or Spanakopita, filled pastry baked or fried is an international favorite.
We want to be the introduction for Sudanese dishes to the New York food scene. Sudanese cuisine has a very unique flavors pairings and is it's influence from across the African continent, the Middle East as well as the Mediterranean. Sudan's different regions bring one of a kind tastes to the food scene with rare dried spices, seeds, roots and fruits unique to Sudan.
Itfadallu! As we say in Sudan, we welcome you to join us on this beautiful introduction to our nations food. We have just launched in March 2018 and serve our samosas as well as a variety of Sudanese dishes at various events around New York City. We offer a variety of meat based, vegetarian as well as vegan fillings suitable for anyone's pallet.
About The Founder
I'm Gladys and was born in Khartoum, Sudan. I grew up in Zurich, Switzerland and have always had a passion for cooking. I consider New York home, as I spent nearly all my summers and winter holidays in this city. Food and culture are synonymous to New York. Throughout my college education and holding various jobs, I always wanted to pursue a food business. New York is fortunately the perfect place to pursue the dream of bring traditional Sudanese recipes that I grew up eating to the World (New York's International Community).


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When Presidents Cry "Hostage!"
To listen to President Obama, you'd think we were in the grip of a never-ending hostage crisis.
In sixteen speeches, statements and interviews this year, including his State of the Union address, he has decried the hostage-taking of one issue or another:
- AID TO SMALL BUSINESS: "Simply put, holding this bill hostage is directly detrimental to our economic growth." Statement on the Economy. -The Rose Garden. 8/30/10
- VETERANS PROGRAMS: "...to sign advanced appropriations into law so that veterans health care will never again be held hostage to the budget battles of Washington." -Address to Disabled Veterans of America, Atlanta, 8/2/10
- UNEMPLOYMENT BENEFITS: "While a majority of Senators support taking these steps to help the American people, some are playing the same old Washington games and using their power to hold this relief hostage - a move that only ends up holding back our recovery. It doesn't make sense." -Weekly Address, 7/3/10
- IMMIGRATION REFORM: Unfortunately, reform has been held hostage to political posturing and special-interest wrangling..." -and to the pervasive sentiment in Washington that tackling such a thorny and emotional issue is inherently bad politics. -Speech at American University School of International Service, 7/1/10
- HEALTH INSURANCE REFORM: "For too long, we've been held hostage to an industry that jacks up premiums and drops coverage whenever they please. Those days are coming to an end." Address to American Nurses Association, 6/16/10
- NOMINATIONS: "The confirmation of well-qualified public servants shouldn't be held hostage to the pet projects or grudges of a few individual senators." State of the Union Address, 1/27/10.
- ENERGY POLICY: "The next generation will not be held hostage to energy sources from the last century. We are not going to move backwards. We are going to move forward." Speech at Carnegie-Mellon University, 6/2/10
But American presidents have been using the "H"-word to make a point and pressure the opposition since long before Barack Obama.
Back in 1902, in his Second Annual Message to Congress, President Theodore Roosevelt warned of the dangers of deploying a naval force of insufficient size to protect construction of the Panama Canal: "...if we have an inadequate navy, then the building of the canal would be merely giving a hostage to any power of superior strength."
President Kennedy had a Cold War concern about the size of the U.S. military contingent in the divided German city of Berlin in 1961:"...we mean to defend our position in West Berlin, and that American troops, who are not numerous there, are our hostage to that intent."
Every U.S. president of the 20th century has spoken of hostage-takings, but many of those times involved the real taking of hostages by a foreign nation or group.
But in 1966, President Johnson may have been the first to use the "H"-word in a purely political sense, in remarks to the nation's governors about federal support for law enforcement. "Practically everything the Federal Government is undertaking is hostage to your enterprise and vision."
Five years later, in August of 1971, President. Nixon was trying to make an assertive point about American currency: "I am determined that the American dollar must never again be a hostage in the hands of international speculators."
It was Nixon who began the use of "hostage" in the way Mr. Obama uses it today: to try to put partisan opponents on the defensive. At his news conference on February 25, 1974, he used the word in response to the Watergate scandal and to answer calls for his resignation. "...it is vitally important in this nation that the Presidency of the United States not be hostage to what happens to the popularity of a President at one time or another."
Each of Nixon's successors has used the word "hostage" in a partisan context.
RONALD REAGAN, in support of a constitutional amendment for a balanced federal budget: "The time to act is now--for the sake of all of our people, for future generations of Americans whose chances for prosperity and opportunity are held hostage by big government's addiction to red-ink spending." - 9/30/92
GEORGE H. W. BUSH, in speech to the National Association of Attorneys General: "We've got to see that the great cities -- indeed, some of rural America -- that they are no longer held hostage to the crack dealers." -3/13/89
BILL CLINTON: in remarks to reporters about getting his childhood immunization bill enacted: "I just want to say that today we're having the Easter egg roll on the White House lawn. You can look out there at those kids. They are the hostages of the Senate filibuster on the program." -4/12/93
GEORGE W. BUSH: in anti-crime speech to the National Organization of Black Law Enforcement Executives: "Let's focus our time and energy and efforts on ferreting out those who hold others hostage in our society and stand side by side with the police officers all across America. -7/30/01
GEORGE W. BUSH: in statement urging Democrats not to add other programs to the Defense and Veterans bill he wants: "It's hard to imagine a more cynical political strategy than trying to hold hostage funding for our troops in combat and our wounded warriors in order to extract $11 billion in additional social spending." -10/30/07
So Mr. Obama is following a well-worn path trod by his predecessors in crying "hostage" for political purposes. The word is an inflammatory one that can help a president make a powerful point, if not score political points against the opposition.
There's nothing unusual about one party trying to get its way by blocking action on an issue important to the other party. When it suits a president to say so, it's holding an issue "hostage." But mostly, it's just politics as usual.
Mark Knoller is a CBS News White House correspondent. You can read more of his posts in Hotsheet here. You can also follow him on Twitter here: http://twitter.com/markknoller.


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Britain has baked in five consecutive days of maximum temperatures above 30C this week in what has been a record-breaking period for hot weather. Temperatures peaked at a staggering 35.1C in Wisley, Surrey on Thursday afternoon, making it the hottest day since August 2015 and setting a new record for 2018. The provisional top temperature for Friday looks set to be 34.7C, recorded at Tibenham Airfield in Norfolk, south-east England, according to the Met Office. But from this afternoon, the tables have turned dramatically as "severe thunderstorms" are forecast to batter the UK, unleashing torrential rain, lightning, strong winds and hailstones. A series of severe yellow and amber weather warnings have been issued by the Met Office, covering various parts of the UK on Friday, Saturday and Sunday.
The hot weather and very high afternoon temperatures have led to an amber warning for thunderstorms valid from 2pm to 8pm in the East Midlands and East of England on Friday. Torrential downpours are possible, with as much as 30mm of rainfall in one hour and 60mm in three hours, while large hail, frequent lightning and strong, gusty winds will be additional hazards, forecasters warned. The yellow warning for thunderstorms is in place until 2am on Saturday and covers London and the East of England. Those in the areas covered by the warnings can expect flooding of homes and businesses, which could happen quickly, with damage to some buildings from floodwater. "Fast flowing or deep floodwater is likely, causing danger to life," the Met Office said of the areas covered by the amber warning. On Saturday, yellow alerts for thunderstorms have also been issued for Scotland and eastern England, while Northern Ireland has been warned of heavy rain.
In Scotland and eastern England, flooding and lightning is expected to cause damage to homes, transport disruption and power cuts. On Sunday, a yellow weather warning covering south-west England will come into effect between 3am and 3pm. Strong winds could gust at top speeds of 50mph and up to 80mm of rain could fall, forecasters said. "The weather conditions on Sunday will come in stark contrast to what has been typical recently, this may increase the chance of impact," the Met Office warned.
Will Lang, chief meteorologist at the Met Office, said the heatwave conditions are "coming to an end" thanks to the barrage of thunderstorms. He said: "While many places will remain dry, the thunderstorms could lead to torrential downpours in places. "Large hail and strong, gusty winds are also likely and combined could lead to difficult driving conditions as a result of spray and sudden flooding. "There will also be some showers up the western side of the UK this evening and this heralds a more changeable and windy weekend."
Lang said the weather over the weekend will be radically different to what Britain has been experiencing over the past few weeks. He continued: "While Saturday will a pleasant, but breezy day in many places, we are in for a change on Sunday with a wet and windy day in stark contrast to what has been typical recently. "We have already issued a Met Office weather warning for the impacts of wind and rain in southwest England and south Wales. "Southerly winds will gust at around 35-40mph and up to 50mph for exposed coasts and hills. "Rain will be most persistent over hills and parts of the Brecon Beacons and Dartmoor could see as much as 60-80mm of rain."


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The Harrow Inn in Knockholt marks the route of an ancient east-west route that ran from the Channel coast of Kent through to Wiltshire. It was known as Harrow Way, which translates as 'Old Way'. Which indeed it was, being a Neolithic trackway and as such described as 'the oldest road in Britain'.
This east-west route is associated with the term 'Pilgrims Way', with its supposed use by pilgrims travelling form Winchester to Canterbury. In recent years much doubt has be cast upon the authenticity of the pilgrim tradition.
This does not of course affect the importance of this prehistoric route which can be traced almost continuously for its whole length, following as it does the lower terrace of the North Downs escarpment. It's just that it didn't originally go to Winchester or Canterbury.
Curiously, this preoccupation with the trackway at the base of the escarpment - the lower Terraceway - is not matched by similar attention to the more ancient trackway at the top of the escarpment - the Ridgeway. The route that this upper trackway followed hardly needs explaining, as it unerringly keeps to the ridge-line. It remains marked out for its entire length by parish boundaries, tracks, footpaths and roads, many of which remain in use today.
For mile upon mile, the Ridgeway and the Terraceway run parallel and remarkably close to each other. Close they may be, but these two ancient trackways occupy very different landscapes.
The lower Terraceway borders highly cultivated land with busy farmsteads and villages at regular intervals, whilst the Ridgeway runs through wild and lonely country, with dense woodland covering the steep escarpment to the south and filling deep valleys that run towards the north. Importantly, the Ridgeway rests on clay soils that in winter are less suited to wheeled traffic, whilst the lower Terraceway rests on drier chalk soils that provide a much more favourable surface.
These pronounced differences probably explain why the lower Terraceway became the more prominent with the passing of years, and why the Ridgeway is now a derelict and forgotten track. In prehistoric times, however, it was the other way round, for it was the Ridgeway that was the preferred route.
This may have been because the Ridgeway enjoyed wider look-outs, more advantageous elevation and fewer surprises than the uninhabited and densely-wooded landscape below. Alternatively, it may have been that it was simply more difficult to get lost on the Ridgeway, with the escarpment continuously and immediately to one side
It's the Ridgeway, not the Terraceway, that crosses the southern part of the Parish of Halstead.
This ancient route, still marked today by a public footpath, begins its descent into the Darenth Valley just north of Fort Halstead, the steep descent itself corresponding roughly with the alignment of Old Polhill Road, eventually crossing the River Darent at Filston Mill, and returning to the ridgeline again above Otford Mount.
In Neolithic times the last piece of high ground on the west side of Darenth Valley would have been a prominent feature on this roadway. It is difficult to imagine that the vantage point that we know as Fort Halstead would have been left unexplored and unused. This piece of land has, no doubt, a longer and more celebrated history than we realise.


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Can see this thread reaching a 1000 pages
Is it just me, or are Paddy Power adverts aimed at the worst kind of hype-driven, laddish cunts in world history?
some right whoppers on there, kin hell
@Bally https://twitter.com/MrCain81/status/733361221207003138
Anyone catch Carragher's hilariously bitter tweet about us after the United/Palace game?
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Jose Mourinho wasn't keen on talking about the officiating mistakes which aided Manchester United in their 2-0 win at West Ham.
Referee Mike Dean wrongly dismissed the Hammers' Sofiane Feghouli in the first half before Zlatan Ibrahimovic's goal was allowed to stand despite replays showing he was offside, the Manchester Evening News report.
United themselves have been on the end of some controversial decisions this season and Mourinho was instead interested in talking about his tactical decision to bring on Juan Mata and Marcus Rashford, who combined to score United's opener at the London Stadium.
"If you speak about the decisions, Manchester United are the champions of wrong decisions," Mourinho said in a broadcast interview.
When it was suggested at his press conference decisions were going United's way, Mourinho replied: "Which decisions? My decisions to play Mata at half-time and Rashford later? Thank you very much."
After a journalist interjected and specified it was the referee's decisions, Mourinho added: "No, not at all. When I play at home I have in my office every details, at half-time I can watch, after the match I watch immediately, I know immediately the Zlatan goal against Middlesbrough is a goal, I know it is a penalty on Rashford minute 76, I know immediately.
"But when I play away I don't have access to that so I cannot comment on that decision, I cannot comment also on Kouyate tackle on Mkhitaryan, I cannot comment."


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Lad tormented after discovering headless corpse in tent near play park
The 19-year-old discovered the mutilated remains and cops are struggling to identify them
A HORRIFIED teenager found a headless body in a park.
The lad, 19, discovered the mutilated remains in a tent near a kids' play area.
Cops have quizzed him as they struggle to identify the rotting corpse — also missing its left arm — or even tell what gender it is.
A close relative of the lad said: "He's traumatised by what he saw."
Forensics combed the scene in Cranhill, Glasgow, Scotland after the clothed body - thought to be lying for "some time" - was discovered last Monday.
The local man was fingerprinted to rule him out of the police probe after he opened the black box tent's zip.
The family member added: "He's had terrible nightmares where he says he sees the body without its head.
"No one can imagine the horror of what he witnessed, it must be 100 times worse than what you see on TV and films.
"He got the shock of his life and found the corpse still wearing a shirt, trousers and shoes.
"Police asked if he saw any weapons or anyone in the area with a bag.
"Officers also took his clothes in case there was any evidence on them."
It's thought two men were seen acting suspiciously days earlier at the spot.
Force insiders would only say the head was "not missing" and it's understood it was found nearby.
The park, in the city's east end near busy Edinburgh Road, had been cordoned off for days while officers carry out their investigations.
"Officers also took his clothes in case there was any evidence on them.
Last night, police refused to be drawn on claims the body was found within a tent.
A spokeswoman said enquiries are ongoing adding: "Following a post-mortem the death is still being treated as unexplained and further forensic work will be carried out to identify the body."


text:
Nestled away in the heart of Fitzrovia sits Pied à Terre a delightfully French, independently owned gastronomic restaurant.
David Moore, founding Director, is the creative influence behind Pied à Terre and with careful management, excellent customer service and attention to detail he has maintained Pied à Terre's longstanding position in London's highly competitive restaurant scene.
♢ ♢ ♢
Arriving at 7 pm on a Tuesday I was met with a warm welcome from the Sommelier who gave me the option to choose my table. They have two restaurant spaces on the ground floor one larger room towards the back, and a smaller room tucked in by the entrance. I chose the smaller room with a table in the corner, which had a great view of all the delicious meals served to fellow (very happy) diners.
♢ Starter ♢
To begin with, an egg box, a plant pot and a pair of red lips were presented. In writing, this does sound rather peculiar, but the styling was charming and memorable! What's more, the contents of the egg box and plant pot was delicious. Inside a blown egg was Eggs Katana seasoned with wild oregano and feta cheese - the size of the blown egg provided a few small spoonfuls, which is just the amount you would want in a starter selection. On the main plate was steak tartare wrapped in a crispy roll - texture wise the roll complemented the steak tartar very nicely, and the meat was lightly seasoned. Sitting next to the spring roll steak tartar was a pair of red lips. To my surprise, the outer case was made of white chocolate and inside was very light fish mousse mixed with dill. It was a combination I had never thought of trying before but one that somehow or other worked extremely well - again I think the crunch of the white chocolate and the softness of the mousse work to complement each other. Next up was the terracotta pot with a radish planted inside in what looked like fresh soil. However, the fresh soil was in fact very finely chopped black olives. The radish was a refreshing palate cleanser to end the first course.
♢ Starter No.2 ♢
◇ Wine - Tampa Giadda Grillo 2015 - Sicilia
To continue with the fresh tastes the next course served was crab wrapped in white radish (Daikon) accompanied by green strawberries and a wasabi sauce and as a finishing touch, it was sprinkled with edible flowers and samphire.
♢ Mains ♢
◇ Wine - L'Alycastre - 2015 - Porquerolles
Presented in a beautiful waved edged bowl was the first main course of Sea Bass, adorned with swiss chard and fish eggs. The sea bass was cooked with scales on, that and the fish eggs gave each bite a satisfying crunch. The XO sauce gave the meal a spicy kick and an oriental twist.
♢ Mains ♢
◇ Wine - IVO Varbanov - Merlot - Syrah - 2015 - Queen of the Night
A change from the lighter tastes so far was the second main course, lamb cutlets. The bone of the lamb cutlet was delicately balanced on a ball of gold leaf with savoy cabbage inside and accompanied by an asparagus sword and a small grilled artichoke. Although by this time you start to feel like you are getting quite full the meal sizes are modest enough for you to maintain the number of courses and delicious enough that you forget you're on your fourth course and pudding has not even been mentioned yet!
♢ Palette Cleanser ♢
Lemon and Yuzu Curd/Dehydrated Raspberry/ Compressed Watermelon with Juniper/Crispy Yoghurt
◇ Wine - Krater - Spatlese Cuvee - 2016- Austria
To make the move from savoury to sweet Lemon and Yuzu curd with compressed watermelon was served on an impressive frosted cube of ice. Very refreshing and the sprinkling of dehydrated raspberry added to the tart flavour.
♢ Pudding ♢
◇ Wine - Jack - 2014 Moscato - South Australia
Last but certainly not least was cherry parfait, surrounded by cherries with a side dish of ice cream. To continue the theme of encasing ingredients in each other (fish mousse in white chocolate, savoy cabbage in gold leaf) within the fresh cherries was a rich chocolate ganache. The cherry parfait and the chocolate ganache balanced each other very well.
♢ Conclusion ♢
The atmosphere of Pied à Terre was warm and buzzy, especially for a Tuesday evening. The staff were attentive and helpful, and the sommelier was particularly generous with taking the time and effort to explain the meals and the accompanying wines, this was noticeable to each table and reinforced by the great thanks that were overheard from departing diners. Overall it was a delicious and enjoyable evening.
☆ ☆ ☆ ☆ ☆


text:
Ibanez AEG8E-TRS Acoustic Guitar, Transparent Red Sunburst
Please contact us to check its condition.
- Typically ships from our warehouse in 1-2 working days
- FREE shipping within Singapore
About this product
The Ibanez AEG8 from the AEG Series which has slender, single-cutaway bodies deliver powerful and balanced acoustic sound, unplugged or through an amp or PA system.
- Series/Shape: AEG Series
- Body Wood: Agathis back & sides
- Bridge: Rosewood
- Electronics: Ibanez SPT Preamp
- Fingerboard: Rosewood
- Neck Wood: Mahogany
- Pickups: Under Saddle Pickup
- Saddle Material: Ibanez Ivorex II
- Top Wood: Spruce
- Tuners: Chrome Ibanez Smooth Tuner AS
- Number Of Strings: 6 strings
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The ATA Chronicle
Featured Article from The ATA Chronicle (March 2006)
Planning, Public Relations, and Promoting New TiesMarian S. Greenfield, ATA President
This past month has certainly been a busy and high mileage one...
The ATA Board of Directors held its quarterly Board meeting plus a Planning Day in Orlando, Florida. Next, the Public Relations Committee leadership met for a strategy meeting in Alexandria, Virginia. Finally, representing ATA, I was the keynote speaker at the Israeli Translators' Association Annual Conference in Jerusalem.
ATA Board Meeting and Planning Day
For the past decade or so, at the first Board meeting after the conference where the new president takes office, the Board has also met for an informal Planning Day. This gives the new Board time to get to know each other and the opportunity to step back and look at the organization overall and its longer range goals. One of the activities has been to determine the association's top three priorities for the next two to three years. Not surprisingly, the certification program continues to be the top priority for ATA. This year, we talked a lot about the certification continuing education requirements, which we all agreed are important for the credential and the program overall, acknowledging that they are also a work in progress. During the Board meeting we charged the Continuing Education Requirements Committee with a general review of the program, to propose additions and changes to the requirements grid and the various points assigned to each category. Committee Chair Arlene Kelly will be soliciting input for her April report to the Board, so you can e-mail any suggestions to the committee at firstname.lastname@example.com .
Another area we all felt needed more attention was internal communications with members. We are trying to address this in many ways, from the new Headquarters phone system, to columns in The Chronicle , to our newly redesigned website. While we are very pleased with the website redesign, we realize that we need to review the actual website content as well. Obviously, we made some changes with the redesign, but the feeling was that more work is needed in this area. To this end, the Board established an Ad Hoc Website Review Committee, chaired by ATA Director Jean Leblon. Jean will be soliciting your input on the website copy and navigation. Please let him know about text that needs to be clarified or reworded plus, of course, any typos, bugs, or bad links. (For more on this initiative, please see the announcement at the end of this column.)
The internal communications discussion was the prelude to the Board establishing a Governance and Communications Committee, which will be chaired by Director Nick Hartmann.
The third priority is to focus on adding and enhancing member benefits. The Board and Headquarters staff have several ideas on this matter. I will share them with you as they develop.
One that came out of the planning meeting is to have a professional designation for ATA-certified translators, along the lines of the CAE designation that appears after ATA Executive Director Walter Bacak's name (Certified Association Executive, awarded by the American Society of Association Executives). We are currently exploring the feasibility of creating such a designation for our profession.
The Board felt that the Planning Day was so successful in integrating the new Board members into the fold and so productive that it should be an annual activity. Therefore, we will schedule a Planning Day in conjunction with the first Board meeting following each Annual Conference.
ATA Public Relations Committee Meeting
There is lots of hot news from the Public Relations Committee. Co-chair Chris Durban has stepped down due to the added responsibilities of her election as president of the Société française des traducteurs, but we are happy to report that she will continue to serve on the committee. Former ATA Director Kirk Anderson will step in as the new co-chair to serve alongside co-chair Kevin Hendzel. The objective of the meeting was to look at what the committee has accomplished thus far and what areas need to be addressed. There will be an increased focus on translation and interpreting issues at the local level?such as medical interpreting?and on communicating with the business press. Of course, we will continue our efforts in working with the national media.
A recent PR effort resulted in ATA being featured on an Internet radio show, which led to a six-part series on ATA and the translation and interpreting professions. For more information, please check out the MyTechnologyLawyer radio show at www.atanet.org/pressroom/ata_in_the_news.php (click on ATA on the Radio).
Israeli Translators' Association Annual Conference
Last summer at the Fédération Internationale des Traducteurs Congress, ATA President-elect Jiri Stejskal and I met Sarah Yarkoni, the chair of the Israeli Translators' Association (ITA), who asked us both to speak at this year's ITA Annual Conference, its first international conference. My keynote address focused on ATA's message of abandoning the poverty cult (thank you to Neil Inglis and Kevin Hendzel), producing a quality product, educating your clients, and promoting enlightened self-interest in the form of serving one's professional association and the translation community in general. Jiri spoke about certification.
Our trip to Israel was a truly memorable experience, for the quality and organization of the conference, but most especially for the incredibly warm welcome we received. We were thrilled to have a breakfast meeting with local ATA members (and some members who had come from the U.S.). We are grateful to the ITA members who took such pride in showing us their cuisine, their cities, their country, and even their homes.
I look forward to seeing many of our newfound ITA friends in New Orleans and to continuing to share my efforts to promote ATA and all the great work done by volunteers to enhance our association and promote translation and interpreting.A Look at the New Website
N ow that the new ATA website is online, we want to know how you like it. The ATA Board of Directors is always seeking ways to augment and improve the information that members and the public at large will find concerning ATA. The website is our most visible channel of communication. For that reason, we want to make it as complete and reader-friendly as possible. On the one hand, we hope that you will find that navigating through the new site is smooth and intuitive. On the other hand, ATA President Marian
S. Greenfield has charged an ad hoc committee with the review of the content of the new website. Our committee will make recommendations for applicable modifications.
In the past, from the results of surveys of the membership and in several other ways, we have received messages of dissatisfaction and suggestions about the current website from a number of members. In order to ensure that we consider in the new website as wide a range of problems as possible, we are asking all ATA members to communicate to us their remarks and suggestions for improvement of the content.
Please visit the new website often in the near future and tell us frankly what you think of the content. Are the sections clearly delineated? Is the language direct and easy to understand? Very importantly, are the indicated links taking you to the pertinent sections, avoiding "dead ends" in the text? Do you find inconsistencies between the various sections? What, in your opinion, do you find is unnecessary or repetitious? What would you like to find that is not on the website now? What information is hard to find?
We hope that you will help us to enhance the content of the website in every way you think it could be improved. We, in turn, will consider your remarks, suggestions, and complaints, and disclose those we believe relevant and applicable in our recommendations to the text writers.
Please address your mail to Jean Leblon at firstname.lastname@example.com any time before May 1, 2006, but the sooner the better. Thank you.


text:
Wayne Rooney has fingered patience and belief as the key factors in Manchester United's return to the top of the Premier League.
United had spent five months - with the exception of a 24-hour spell in February - in second place behind local rivals Manchester City.
But their 2-0 win over West Brom on Sunday, coupled with City's simultaneous 1-0 shock defeat at Swansea, has seen Sir Aex Ferguson's side nose one point in front with 10 games left.
Rooney, who took his goal tally for the season to 26 with his brace against the Baggies, identified the qualities that have enabled United to win on the day and seize the initiative in the title race.
"Sometimes you need to keep your head and keep your patience," said the England striker. "We managed to do that, create a few chances and thankfully I got the goal before half-time which settled us.
"It's great credit to the team for the hard work and spirit we've shown to keep tallying up those points."
Rooney revealed how the reaction of the Old Trafford crowd told United's players than Swansea were on their way to a surprise win over City.
"We knew Swansea had scored," he said. "We didn't know if it was 1-0 or 2-0, but we knew they'd scored.
"We just had to stay focused and make sure we kept playing our game and see the game out.
"There's a long way to go, but it's nice to get to the top of the league and be looking down. Hopefully we can stay there now."
Rooney feels Sunday's win was a potentially seismic moment in the context of the title race.
"West Brom made it difficult for us," he said. "They got a lot of men behind the ball.
"Getting the goal in the first half helped settle us down and we could have scored a lot of goals, but the most important thing was the three points.
"We had chances and were just thinking 'We need to take one'. Anything can happen - they can have a half-chance or a breakaway.
"We knew we needed to get that second goal.
"It was vitally important we did that and then, from there, we really saw the game out."
Tevez can save us claims City's Richards
Mancini: City must be united to win title


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Christians believe there isn't anywhere they can go where God can't look after them. The Bible teaches that God knows where everybody is and what they are doing all the time.
Sometimes people can feel uncomfortable thinking that God sees and knows what they are doing, especially if they do something wrong or make a bad choice. However the Bible teaches that God is kind, loving and patient. Christians believe that God sees the wrong things they do but he is quick to forgive them as soon as they say they are sorry and he promises to keep on guiding them as they learn and grow to live his way.


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I'm not Roman Catholic, but my Polish relatives (my mother's side--dad was Arab) have something called 7 fishes for Christmas Eve and the Breaking of Bread--and pierogies for Christmas Eve as well. No meat is served that I recall. The pieorgies I think are everyone's favorite dish. Though I avoid gluten as much as possible, I indulge in at least one each of the cabbage, sauerkraut, and potato.
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Currently on display in the 4th floor of the Gladys Marcus Library, Decades of Drop Dead Designs highlights selections from the rich history of FIT student fashion shows available from the library's Special Collections and College Archives unit. The exhibition spans 66 years, from a show held in conjunction with FIT's first commencement exercises in 1946 through materials from 2012. These include photographs from the 1940s to 1960s, original programs from the fashion shows, and features from the Portfolio yearbook, as well as items from the college days of noted alumni Byron Lars and Antonio Lopez. Plus this video of the Soul Club Fashion Show from 1982!
The exhibition will be on view for the Spring 2018 semester.


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It's only been a day since Battlestar Galactica alum Katee Sackhoff teased social media with a tweet suggesting that she may be part of Season 4 of CW's The Flash. And reports today do indeed confirm that the actress will be facing-off with Barry Allen, and she'll be playing the established DC comics villain Blacksmith.
It was during Sunday that Sackhoff tweeted a picture of a script, indicating that she was currently memorising the dialogue for a project and that all would be revealed on Monday. Going by clues on the picture, which seemed to feature a lightning bolt and a possible reference to "Berlanti Productions", it didn't take long for people to calculate that this was likely a role in the upcoming season of The Flash. The tweet was later deleted, with the powers-that-be probably deciding that people were savvy enough to figure out the clues before a company announcement. However true to her word, the information about the role has been officially released today, and it's good news for fans of Sackhoff and DC villains.
According to EW, Sackhoff is joining the cast of the show as the DC metahuman villain Blacksmith. Otherwise known as Amunet Black, she's a tough and uncompromising boss of an underground black market for supervillains, using blackmail and subterfuge to bend them to her will. The character is due to first appear in episode 5 of the new season, which is intriguingly called "Girls Night Out". This will also be a mini-crossover Arrowverse episode, as it will feature Emily Bett Rickards as Felicity Smoak. It's also revealed that Blacksmith will be a recurring character, so we can expect an arc for her during the season and she won't just be a villain-of-the-week.
In DC comics Blacksmith first appeared in 2001, in the story Flash: Iron Heights. She definitely has metahuman abilities in that universe, being able to fuse organic and inorganic materials, which allows her to mutate her own body and create powerful weapons. She is primarily known however for organizing her own team of rogues and using her contacts to defeat Barry Allen and his companions - even if those are only fleeting victories. At the moment it's unknown just how close the Arrowverse version will be to the comics, and whether she'll have comparable metahuman powers, but you can bet that Sackhoff will be playing her as a formidable opponent.
Season four of The Flash seems intent on building up a new group of rogues for Team Flash to fight. We already know that Sugar Lyn Beard is Hazard, and that Neil Sandilands is The Thinker - with him almost definitely set up to be the "big bad". Now that another powerful threat like Blacksmith is thrown into the mix, it should be interesting to see how it mixes things up with Barry and his colleagues. Coincidentally, Blacksmith and Thinker have clashed previously in the comics, so that could make things even more complicated if that possibility is also explored. At any rate, Sackhoff should be a strong and popular addition to the existing cast and we eagerly await further details.
MORE: The Flash Season 4 Introduces Another Harrison Wells
The Flash returns to The CW on Tuesday, Oct. 10.
Source: EW


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adelrosario necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 60 diseños de 15 diseñadores freelance.
We're not a business, per se -- we're the IT deparment of a major silicon valley software company -- but we aim to run things like a business, and we're launching an internal branding initiative to "put a face to IT." To give you a sense of what we're trying to accomplish:
Our Current Situation:
- We know little about our customers (end users)
- We have no ability to engage end users except for surveys and help desk tickets
- Our users are currently victims to disparate, uncoordinated IT outreach/initiatives
Our Strategy:
- Focus on initiating and maintaining LONG TERM relationships with end users (our "customers")
- Get to know customers and their history
- Build and maintain our IT brand so we can:
- Set expectations of "the IT experience" before customers even interact with us
- Sell our IT vision: "I am more successful at my job because of IT"
- Communicate, communicate, communicate
- A new IT internal, online community and corresponding new way of engaging with IT will be a core piece of our strategy
We want the logo to represent everything we already are (knowledgeable, dependable, innovative) and some things that we are not (YET!) but that we aspire to be: RELATABLE, APPROACHABLE, humorous, sometimes irreverent, but through it all, maintaining professionalism and delivering value with each interaction.
Ideally the logo will serve , not just as a means to identify us to our customers, but also inspire us through our evolution. We know it's a lot to ask of a logo, but we have faith that you're up for the challenge, so join the evolution and submit your design today :)!
Our target audience tends toward the conservative, but we're hoping to change that and loosen them up a little, specifically for the purpose of getting them to open up and "engage" with us!
If you need any additional information, please don't hesitate to ask.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Guide part 12
Catnap: Part 2
Availaible Mechs - Madcat
Time of Day - 1730 TSD
Terrain - Forest
Weather - Clear
Ambient Temperature - 14 Degrees Celsius
Okay, not quite head pat time. But you'll be in your bright shiny Mad Cat right now. You'll learn quickly that this mech overheats fast, but it kills almost anything it hits. The area around the Icarus is set up with some Dragoon equipment, so pick-up any weapon power-ups you find. When the first wave hits, use missiles on the various tanks and VTOLs, switching to the machineguns to cool off. Keep your PPCs reserved for the heavy stuff, and only when you get rid of the tanks and VTOLs. In groups, these conventional war machines kill the dropship fast, but are relatively easy to kill. Foster will attempt to help you in a friendly Cougar but doesn't do much except get rid of the occasional tank or VTOL. Remember to keep the target jamming on as much as you can. Keep moving as well; you'll know that you get hit more as the Mad Cat if you stay still since it cannot move as fast.
The second wave comes down hard with a half dozen VTOLs and two Uziels. Take out the VTOLs quickly, then start hammering at each mech in turn. If you can, fight along with Foster. If he hits an enemy mech, its attention will turn towards him (and he will usually jump away before being hit), leaving you free to press your attack without fear of getting hit. Use target jamming to spoof the PPC shots and you should take out both Uziels with little or no trouble. Be sure to use the power-ups of the ifrst dead mech to finish your fight with the second mech. Once the second wave is crushed, you clear the mission and get a short and furious head pat from C.O. babe.
Was this guide helpful?


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The Workers' Compensation Act is a set of laws administered by a state agency, known as the State Board of Workers' Compensation. The Board governs what workers, employers and insurance companies are supposed to do when a worker is injured on the job or gets a disease caused by the job. It is usually called "workers' comp."
With very few exceptions, workers' comp applies if your employer has three or more employees when you are working there. The Workers' Compensation Act requires that employers provide two kinds of benefits to the injured employee, at no cost to the employee. The first needed benefit is the medical benefit. The second (and equally important) benefit is the income benefit. Income benefits must be paid if an employee is off work due to the work-related injury. The law covers full time, part time, and temporary employees.
Posted in: Workers Compensation


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Deskside Technician II
at Stefanini
Job Description
USA - New York
Work City:
New York
Job Category:
Field Services
Who we are:
Stefanini is a full service global provider of offshore, onshore and nearshore IT services, including application development and outsourcing services, IT infrastructure outsourcing (help desk support and desktop services), systems integration, consulting and strategic staffing to Fortune 1000 enterprises around the world. We have over 25,000 employees across 77 offices in 40 countries across the Americas, Europe, Africa, Australia, and Asia.
What will you do?
- Provide hardware/software support services to onsite client including break/fix, installations and working with any necessary third party groups
- Implement virus detection and eradication procedures
- Diagnose end-user system failures and implement repair solutions
- Diagnose printer and other peripheral devise failures and implement repair solutions maintain Toner replacements as necessary
- Troubleshoot network devices in order to ensure connectivity from the PC to the Network
- Providing installation and upgrading services of hardware and software
- Deployment, Configuration and troubleshooting of phones and other mobile devices, tablets, PDAs, etc.
- Setup and troubleshooting audio/video equipment such as projectors and video conference equipment
- Provide backup solution for end user data and restoration as needed
- Maintain loaner pool for laptops, mobile devices, etc.
- Track all work performed in incident management tool
- Support Project deployments
- Store Opening, Relocation and Closing
- Integrates Best Practices with our client's Support Groups and Third Parties to Conduct PC imaging
What do you need to succeed?
- High school diploma or equivalent required
- 1-3 years of relevant experience
- Knowledge of multiple manufacturers and operating systems
- Excellent troubleshooting capability
- Ability to work in a team environment as well as independently
- Ability to communicate technical information to non-technical audiences
- Excellent verbal and written communication skills
- Ability to complete assignments with no supervision
- Ability to search internally/externally for support information
- Customer-oriented attitude
- Ability to travel locally and in-state to support other sites, if applicable
- Valid driver's license and proof of auto insurance, if travel is required
- Attendance and schedule adherence are requirements of this position
- This position includes continuous walking, bending and lifting equipment sometimes up to 50 pounds and engaging in labor related duties of connecting computer equipment
- Knows and applies fundamental concepts, practices and procedures of particular field of specialization
- May develop advanced skills using tools and equipment appropriate for the position or specialization
- Using established procedures and working under immediate supervision, performs assigned tasks
- Work is routine and instructions are usually detailed
- Resolves routine questions and problems, and refers more complex issues to higher levels
What you'll get:
- Work with brilliant minds, often within a global capacity;
- Comprehensive Benefits package that includes 401(k), paid time off, tuition reimbursement, medical, dental and vision insurance, and much more;
- Opportunity to participate in professional development eLearning programs within the Stefanini University, and other virtual trainings as well.
Why we're different:
- Brazilian and privately owned company;
- Agility, flexibility, and innovation are in our DNA;
- Flat organizational structure which enables faster communication and decision making!
Take a look for yourself!
Here's one of our own, talking about the culture, space and growth opportunities: https://www.youtube.com/watch?v=j8O37KNINdY
receding job description has been designed to indicate the general nature and level of work performed by employees within this classification. It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities, and qualifications required of employees assigned to this job.


text:
A guilt-ridden wife writes a touching letter to her husband.
Heavily burdened, her letter revealed her adulterous relationship with another man, detailing their moments together and the feelings he awakened in her. It also spoke of her grief and despair over her lover's death, suspecting that it was her husband who killed him because he knew all along about their relationship.
In the end, one question must be answered: Should she be scorned, or pitied?
My dear Husband,
I don't know if words will ever be enough to tell you everything I wanted to say. Or if this, in any way, can assuage my guilt. I just want to get this out of my chest because it pains me so much.
As you read this letter, please believe me, I never meant to hurt you. I love you. I never stopped loving you, even when I was with him.
I'm so sorry I was unfaithful to you. I'm not proud of it. There will never be a logical reason or explanation for my behavior. I won't even dare rationalize my actions and turn the blame on you. No, you don't deserve the blame. You, who have been my anchor of strength, my pillar of hope ever since I can remember. You, who have been the kindest to me even when I was not, who accepted me despite my flaws and faults, and gave me security and comfort in life.
I know. I should be cursed. I should be flogged. I should be punished.


text:
Tickets still available for Carols for Christmas service for a good cause
PUBLISHED: 10:47 11 December 2018
You've voted for your favourite Christmas carols in our poll, now come along to our Carols for Christmas service tonight to hear them in the atmospheric surroundings of St Peter Mancroft Church.
Along with mince pies, mulled wine and garish jumpers, Christmas carols are at the heart of seasonal tradition, with the classics observing the birth of Jesus Christ and the more contemporary versions celebrating the merriment of the season.
For those who prefer to forgo sleep in heavenly peace to sing for the twelfth night in a row, Christmas carols can be heartwarming experience bringing young and old together. 'Tis the season to be jolly, after all.
But what is Norfolk's favourite Christmas carol? According to our poll results it is in fact Silent Night.
Carols for Christmas
This year, the Eastern Daily Press and Norwich Evening News Carols for Christmas service will take place at St Peter Mancroft Church, Norwich, on Tuesday, December 11.
The joyous occasion will raise funds for Norwich-based charity The Hamlet Centre, which provides recreational, educational and social opportunities for children and adults with profound disabilities and complex health needs.
Doors will open at 6pm with the service scheduled to start at 7pm.
Tickets cost £5 and can be booked by calling 01603 772174 or online at www.edp24.co.uk/carols.
Tickets can also be bought in person at the front office of the EDP and Evening News head office in Rouen Road, Norwich and will be available to buy on the door tonight.


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Marketing Orientation Assignment Help
Marketing orientation has many facets. There is five marketing orientation perspective named as Decision making perspective, market intelligence perspective, strategic perspective, customer orientation perspective and culturally based behavioral perspective. Marketing orientation is quantitative and can be measured with the help of marketing orientation measurement scales.
Two most widely used scale for measuring marketing orientation are MARKOR and MKTOR. MKTOR is an average of three components namely: customer orientation, inter-functional coordination, and competitor orientation. MARKOR scale, on the other hand, takes average of the scores of three components named as Intelligence generation, intelligence dissemination and responsiveness.
It is an emerging field and many students land up in the job where Marketing orientation analysis is the primary role. Our experts can help with Marketing orientation assignments because they are working in the same domain.
Different Perspective of Marketing Orientation
- Decision making perspective
- Market intelligence perspective: It is the everyday information important to a company's markets, gathered and analyzed specifically for the purpose of accurate and confident decision-making in determining market opportunity etc.
- Competition Orientation Perspective: What competitors are doing is important for a company. It gives an idea about the product standing, design and innovation.
- Customer orientation perspective: It is important for the company to focus on the customers for a long term profitability.
- Culturally based behavioral perspective: How the customers reacts to a product on the basis of the inherited values from their family is another important aspect to look after for the companies.
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Skin Lesion Features Extraction and Classification with SVM in Real Numbers Clifford Algebra and Neural Network
The speech will start with the introduction of methods and techniques forfeatures extraction from skin lesion images. The features under considerationare from melanoma diagnosing systems in clinical use. Next, the speaker willshow features selection and ranking according to the features significance forskin lesion classification. This way a subset of 5 features is determined as mostimportant and they are used to create a skin lesion signature in the form of skinlesion feature vector (LFV). Further, the speaker will present binary, ternaryand quaternary support vector machines (SVMs) to classify a skin lesion to twoclasses (benign-B and melanoma-M), three classes (B, dysplastic nevi-D, andM), four classes (B, dysplastic nevi mild- Dm, dysplastic nevi severe – DS, andM). During the next part of the talk the presenter will acquaint the audiencewith basic concepts from Clifford Algebras: Clifford product and calculus,multi-vector, Clifford sub-spaces and operators. Then he will show thedevelopment of new formulae for calculation of the multi-vector coefficientsand their implementation to map a multi-vector to Clifford Algebra sub-spaces.Then the speaker will show skin lesion classification results by SVM in theClifford Algebra sub-spaces. On the next stage he will compare the obtainedresults with classification results: in the field of real numbers; diagnosing rulesin clinical practice; and contemporary neural networks (NN). The speech will end with a brief description a convolutional NN architecture and itsimplementation with a stochastic gradient descent learning classification of a3800 images from the ISIC2017 dataset.He will discuss about several machine learning and/or deep learning approachesdeveloped by this team to facilitate automated analysis of AMD and DR.


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Highway 1 at Paul's Slide will soon reopen to one-way traffic
Highway 1 at Paul's Slide should be open to one-way traffic by the end of the week, Susana Cruz of Caltrans said Monday.
Meanwhile, she said, Caltrans continues to conduct geological testing on the larger Mud Creek Slide, 9 miles north of the Monterey County line.
Cruz, Caltrans District 5 public information officer, said the only remaining holdup for reopening the highway at Paul's Slide, as of Monday, was a single large boulder.
"We're hoping to have it open at the end of the week," she said. "There's one big boulder that they need to get rid of. They need to bring it down and blast it. It could be a day or two."
Cruz gave a timeline of somewhere between Tuesday and Thursday to open the road at Paul's Slide, which would likely be subject to one-way traffic control 24 hours a day, seven days a week.
Traffic would be routed "primarily on the southbound lane, just to allow for any catchment or any other slide activity," she said.
Paul's Slide is about 22 miles north of the Monterey County line, so traffic coming from Cambria, San Simeon and points will still be blocked by the Mud Creek Slide, which is farther south. Currently, northbound traffic can't go farther than 5 miles north of Ragged Point.
That traffic can only reach the Gorda area of the coast and Limekiln State Park via a long inland detour using Nacimento-Fergusson Road.
Caltrans engineers are busy testing the Mud Creek Slide, and Cruz said those tests likely would continue through sometime in August.
She said Caltrans is "still looking at options about what the best viable solution will be."
"By taking time now, we hope to be able to save time later. We're taking our time to make all the assessments necessary."
Until the road reopens at Paul's Slide, access there is restricted to limited windows for local residents and deliveries:
▪ 5 to 6 a.m. and 7 to 7:30 p.m. Saturday through Thursday.
▪ 5:30 to 8 a.m. and 6 to 7:30 p.m. Friday.
Meanwhile, steel girders continue to be fabricated in Vallejo and trucked to the site of a new $24 million bridge to be constructed over Pfeiffer Canyon, 45 miles north of the county line. Cruz said that project is on schedule for completion in September.
The old bridge failed after heavy rains saturated the hillside, and the entire span had to be torn down.


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Salty Boho - Meet two creative entrepreneurs!
As we started Salty Boho we wanted to remain subtle in the background. But as we grew and as the brand developed - the more we realised we ARE the brand. We live and breathe this brand. Therefore we find it crazy not to show you guys who we are, what we do and what our vision and mission is with this sweet baby - Salty Boho. Here we go!
Hello ladies, what are your names and where are you from?
Both: We are Malin (pronounced like Marlin the fish but with no R, any questions on that?) and Sofia. We're from Sweden but do consider ourselves world citizens since home has been wherever we put our bags for the last 8 years.
Describe yourselves with 3 words!
Sofia: I'm a happy, adventure-seeking daydreamer.
Malin: Energetic, social and super expressive (I sound like a lunatic, I love yoga, and being quiet sometimes too).
Where do you live now and what do you do for a living?
Sofia: Recently came back to Sweden from living in Margaret River in Western Australia. Epic place with heaps of surf, vineyards and nature. Besides Salty Boho I work as a Freelancing Graphic Designer, a true digital nomad!
Malin: Just returned to Sweden after a summer spent in Cornwall, South England. It truly is a well kept secret down there, magical surf, happy people and beautiful landscape (and men with british accents). I also freelance as a Digital Communicator with a passion for text, clean design and capturing the beauty of the world through my camera lens.
What are your favourite places to 1. Work from 2. Travel to?
1. Holland, Amsterdam. I love this city. Its full of creative people, happenings and has got a great happy spirit. It makes me more creative and super inspired!
2. New Zealand (read Malins explanation below) and Bali. I've been there so many times, I literally know the island inside out. So many amazing little hidden spots, nice people and great surf.
1. Sri Lanka, as I love the warmth, both from the people and the weather, the simple living, its magnetic powers to gather creatives from all over the world in one place and the waves. It is paradise on earth!
2. New Zealand. That place has really got it all! The fact that you can go skiing, bungee jumping and surfing is just amazing, you just can't beat it. And Hawaii, I (we) love Hawaii!
How do you know each other and why are you the greatest team alive?
Both: We knew of each other from the age of 17 where we briefly ran into each other on different adventures. Then we sort of had to get to know each other when we were 19 and moved into a tiny room in Oslo, Norway together with one more friend to work and save money for our first travel (that Sofia initiated). Since then we have explored Southeast Asia, Borneo, Bali, Fiji, Australia, New Zealand, South America, Hawaii, California, Europe and all corners of the world together.
Why we're the greatest team alive? Because we think the same yet we have different qualities to compliment each other in the process of making things happen. Sofia is a bit more structured, and has got a killer Graphic Design and creative mind and Malin loves text, communication and all things pretty.
Why did you start Salty Boho, what is Salty Boho to you?
Both: After a lot of dreaming, this was actually Sofia's idea, she sort of put the website and brand together and sent Malin a message saying, we're doing this! And from there we got this idea to start selling our rings that we found travelling and go from there. To us, Salty Boho is where we get to communicate and promote a lifestyle and way of life that we didn't know existed until we started living it ourselves.
Malin: I remember feeling like I had heard about people freelancing, surfing and travelling at the same time, but who were they and how did they do it? I didn't really have a role model for this as universe pulled me on to this track of life.
Both: With Salty we hope to inspire others to take a step out of their comfort zone, to actually feel, recognize and learn what makes them happy and what their heart truly desires and GO DO THAT.
What can we expect in the future from Salty Boho?
Both: Great things!!!
Sofia: It's funny, as without knowing both of us have painted this picture in our heads of Salty Boho in a small space in the heart of Gothenburg, Sweden (hey, you gotta start somewhere), with white painted walls, full of beautiful ocean prints, palm trees and freelancing desks, a small café with the most amazing coffee and seats for other freelancers to come in, work, network, hold workshops and have fun with us!
Malin: Let's just say that we could sit down for days and dream about all the things we would like to do in the future, but yes, we hope to do some workshops for smaller brands and female entrepreneurs, start a freelance office, a café, run the world etc.
If you could go back in time 5 years and give yourself one piece of advice, what would it be?
Sofia: Trust in yourself. You are so much more valuable than you think! As a freelancers/small business owners it's really hard in the beginning to believe in yourself and see you're actual worth. In order for others to believe in you, you need to believe in yourself. So let everyone know that you're a freaking superstar and an expert in what you're doing, and they'll follow!
Malin: Trust the process. There truly is a reason for every person, experience and challenge you meet along your way. It is so beautiful when all of a sudden it all comes together and makes sense, how you ended up where you are and to realise you have been exactly where you had to be the whole time. And to doubt is healthy. People who has got all the answers scares me!
Finally, life mottos/rules to live by/rules to break etc, do you have any?
Sofia: I got hot sauce in my bag - SWAG!
Malin: Be a spiritual badass: Send out love to strangers, always seek out the lesson and know that happiness is a choice.
THIS OR THAT (let's see how this "greatest team" actually works)
Coffee or tea? A good espresso. Every damn day!
Snowboarding or Surfing? Haha is that even a question? We'd surf every day all day if we could. (Sofia doesn't really agree here as she's an old snowboarder but broke her foot in New Zealand, so she physically can't snowboard every day, therefore we decided to go with surf).
Burger or Taco? This is where we go our separate ways. Malin likes would kill for a good fish taco with a Corona and Sofia really likes her hipster burgers with a pale ale.
Netflix or Youtube? Oh another tricky one. Sofia is a Youtuber since young age and knows Youtube like her own backpocket. (Sofia: There are so many awesome people to discover on Youtube, people share great content and there are so many tutorials to learn new cool things, for free. I LOVE IT). Yet we both love documentaries and binge watching Stranger Things, so we will probably have to go with Netflix. Also Malin is scared of Youtube, (still can't get my head around the fact that like 2 million people likes to watch someone play a video game while they comment on it. Why?!).
Bikini or Suit? Bikini. Every damn day. YEEW
Follow us for more adventures; @sofiaparker and @malinsjostedt !


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In this tutorial, we learn how to tie a turtleneck knot. First, take your long scarf and find the middle. Next, wrap the scarf behind the back, and bring the ends to the front. Loosen the scarf up on the neck, then make a knot. Try to get the scarf to lay as flat as possible, then tuck the knot into the neck cover. You can let it hang loosely, or flare it out on the sides. This is a great way to wear your scarf in the winter, because it will keep your neck warm as well as your body! You can also do this with any design and color to keep things interesting with your outfits!
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The Herndon Gallery at Antioch College is staging a new exhibition featuring the work of New York City-based artist (and Antioch alumnus) Michael Hambouz. The exhibit features 2D and 3D pieces from Hambouz spanning multiple mediums and over two decades of work. He spoke with WYSO's Niki Dakota on Excursions about his work and his inspirations and influences during his time at Antioch.
Listen to the interview HERE


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The whole purpose of this month mix marathon is to showcase the different styles of music that I get down with. A lot of people get confused when I play top 40, House, or dubstep (because of my background in Rap/R&B) at my live gigs and they are confused because they just don't know my musical depth, I really don't think there is a genre of music that I totally dislike.
Now on to this week, this week is the house mix, I'll be taking you on a ride down the house side of things with artists such as Fifteenth,Benny Benassi,Duck Sauce,Deadmau5 and more! As always enjoy!
1. Daft Funk- Social Disco Club
2. One More Time- Daft Punk
3. Tomorrow- Fifteenth
4. Show Children Love- DiscoTech
5. The Weekend- Michael Gray
6. Come Fly Away (Adam k & Soha Remix)- Benny Benassi feat. Channing
7. Pon De Floor (Joe Maz 1992 Bootleg)- Major Lazer
8. Give it Up- The Goodmen
9. Pistol Whip (Paul Anthony & Zxx Remix)- High Caliber
10. Buggin Out- DiscoTech
11. aNYway- Duck Sauce
12. No Worry- Danny Daze & Whitenoize
13. Rock WIth You (WHite Label Mix)- Daft Punk/Michael Jackson
14. Soul Bells- Le Knight Club
15. Big Bad Wolf- Duck Sauce
16. I Remember (Vocal Mix)- Deadmau5 and Kaskade
17. Atmospheric Beats- Kerri Chandler
Listen here:
Download this mix and more from my iTunes Podcast!--->iTunes


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- Distance from Airport
45 Minutes
- Transfer
- No. of Rooms
- Wifi Available
- Winner of Leading Website Resort 2012
- Diving, snorkeling & surfing
- Luxurious spa with signature treatments
- Symbolic Weddings
- 4 star resort
Soak up the enthralling sights and sounds of a truly magnificent tropical island at the Adaaran Select Meedhupparu, Maldives situated on the dreamscape of Raa Atoll. Complete with a host of contemporary facilities and array of activities, the award winning luxury resort ensures an unmatched holiday in the tropics.
Beach Villas
Elegantly furnished and wooden interiors creating a warm setting, the Beach Villas provide panoramic views of the horizon. Granting easy access to the stunning shoreline, the air conditioned villas are situated directly on the white sandy beach.
Main Restaurant
Serving remarkable multitudes of cuisines and flavors each day, Main Restaurant of the resort provides tantalizing buffets prepared with the use of fresh produce and ingredients. Promoting a charming setting complete with attentive service, the restaurant offers enticing delicacies from around the globe.
- Laundry Service
- Safety Deposit Box
- Internet Facilities
- Shops
- Meeting Facilities
- Salon
- Sauna & Steam Room
- Business Center
- Swimming Pool
- Gym
- Reflexology Centre
- Medical Facilities
- Wedding Preparation
- Chinese Therapy
- Table Tennis
- Badminton
- Beach Volleyball
- Beach Football
- Water Sports
- Night Life
- Excursions
- Fishing
- Snorkeling
- Diving
- Island Hopping
- Cruising
Providing tranquility, privacy and pampering treatments, the Chavana Spa offers an array of signature body treatments, facials and packages inspired from the Balinese garden. Nestled in lush vegetation, the spa features three double rooms, four single rooms, steam & sauna, manicure and pedicure area.


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Friday Dinner:
Cajun Shrimp Alfredo $13.99
Tiger shrimp sautéed with fresh garlic, peppers and tomatoes then tossed in a creamy Creole Alfredo sauce with penne pasta. This dish is served with your choice of one side.
Prime Rib Hoagie $9.99
Marinated prime rib grilled with onions and served on a hoagie roll. This dish is served with hand cut chips and a sliced pickle.
Crab Cake Spinach Salad $15.99
A lump crab cake served over a bed of fresh greens with red onions, bacon crumbles and a hard-boiled egg. This dish is served with homemade Honey Bacon Vinaigrette dressing.
Smothered Sirloin $20.99
A grilled to order 8oz center-cut Sirloin topped with sautéed mushrooms and brown gravy. This dish is served with your choice of one side.
Today's Soup:
Chicken & Sausage Gumbo
Today's Side
Cheesy Broccoli


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If you can see your home, building and appliances through the lens of an holistic engineer and inventor a lot will be possible. You will understand the function of several part of your building, your installations and appliances. At one your refrigerator, your air conditioner and so on are not energy consuming units anymore but can be changed in food production units by using the waste energy. Your roof can be used in the climatising of your home or even turned into a food production unit. This training will reveal a frame work with 7 simple steps that give you in dept knowledge and skills to adapt your home, installations and appliances in order to elevate your well-being, live more energy efficient while at the same time monetizing on your energy bill and do the things you always dreamed of.
Mastering the "no waste" principle on your home, installations and appliances and knowing how to apply renewable energy systems will change your live forever and more over you can elevate even more by becoming a entrepreneur in this area and live your dreams
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Good God (Part 3)
I know God is not fair, neither is he predictable or safe. And I don't want Him to be fair, predictable, and safe. But God is good, and I desperately need to know and believe this about Father God. I realized that I had defined "good" using the term "fair," and that was a critical mistake. Because I failed to define "good" correctly, and believed goodness to include fairness, I wound up with a perspective of God that rendered Him neither fair nor good. Oy vey!
God is not fair.
He is not safe.
He is not predictable.
But God is good.
I realized as I worked my way back over the battlefield, picking up the pieces of my composure and my theology, that I know a great deal about fairness, safety, and predictability. But, I don't understand goodness nearly as I need to.
I dropped my perspective, ceased reconnoitering the battlefield, and voiced a new question: "Father, you have listened patiently to me berate and misjudge you and cast you in my own image. I apologize. Jesus said, 'None is good except for God.' I believe what He said. Father, would you help me understand your goodness?"


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we'll see you running the lowcountry
We are like a "Hilton Head running company" that doesn't charge a thing! We are proud to host FREE group runs every Saturday morning. Whether you're a runner, a walker or just getting started we'd love to see you! All of our group runs are FREE and open to the public. If you're visiting the area on vacation, you're welcome to join us. We have courses for all fitness levels and would love to help you achieve your goals.


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E-design differs from in-person interior design in a few ways. The client is responsible for quite a bit more work than would typically be asked of them- which makes it ideal for the D.I.Y.ers and those with a passion for home projects. Clients will be asked to take measurements and photographs of their space as well as provide a simple floorplan to help me visualize their home since I will not physically be there.Read More
Before installation begins, all approved furniture and decor must be ordered. This occurs after clients sign off on items they approve for their design. I never purchase or install items in a clients home they haven't already signed off on. Creating this paper trail of approved items helps me make sure nothing gets overlooked and helps my clients see exactly where their money is going.Read More
Upon client approval, I can begin working on technical aspects of the project. I create a detailed set of documents that include floorplans, elevations, and schedules. Similar to how renderings help clients see my vision in the design presentation phase, these documents ensure that all contractors, the clients, and I are all on the same page during the install phase.Read More
How does it work? I begin by making another site-visit to take photos and measurements of any spaces being redesigned. Reference photos and measurements limit unnecessary site-visits and ensure that I am able to accurately visualize your space while I am picking out furniture and decor.Read More
A double date night at home is such a brilliant idea. Good food + good friends + the comfort of home= Perfection. I designed this heart-themed tablescape for a small, at-home double date party just in time for Valentine's Day. I was inspired by pastries for this design, so I looked to some of my favorite cookbooks for inspiration when creating the color palette and picking the textures throughout the design.Read More
Initial consultations are often my first physical point of contact with a client. Clients contact me with a variety of reasons to start their project- the two most common reasons being;
- They have just relocated and they need help figuring out how their existing furniture fits into their new floorplan and what needs to be replaced.