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Paolo Sassone-Corsi, PhD - "Metabolism meets Epigenetics: the Circadian Clock Link"
Nov 07, 2017
from 12:00 PM to 01:30 PM
|Tigem Auditorium "Vesuvius"
|Contact Name
|Andrea Ballabio
|Contact Phone
|Add event to calendar
The circadian clock is responsible for biological timekeeping on a systemic level. The mammalian central pacemaker is localized in the hypothalamus, in a paired neuronal structure called the suprachiasmatic nucleus (SCN). The discovery that all tissues and virtually all cells contain an intrinsic circadian clock revolutionized the field, providing a conceptual framework towards the understanding of organismal homeostasis and physiological tissue-to-tissue communications. The circadian clock controls a remarkable array of physiological and metabolic functions.
A highly specialized transcriptional machinery based on clock regulatory factors organized in feedback autoregulatory loops governs a significant portion of the genome. These oscillations in gene expression are paralleled by critical events of chromatin remodeling that appear to provide plasticity to circadian regulation. Specifically, various protein acetylation events appear to be under clock control and cycles in both acetyl-CoA and NAD have been linked to circadian control of gene expression. This, and additional accumulating evidence, shows that the circadian epigenome appears to share intimate links with cellular metabolic processes and has remarkable plasticity showing reprogramming during aging and in response to nutritional challenges. As circadian rhythms are intimately linked to aging, and caloric restriction remarkably influences both processes, we have been filling this void in knowledge by revealing the molecular and cellular links between nutrition, metabolism and epigenetic control.


text: If you needed yet another reason to want to work at Google, here's one: Google Tech Talks. Apparently Google brings interesting folks from around the world to talk on various subjects. I downloaded one and watched it on the Google Video Player in full screen. The talk was on wave energy, and they had a senior engineer from a Scottish firm in to describe all the juicy details. It was really interesting, and quite accessible. Have a look at what they have available. Hard to say no to neat stuff for free.

subset: commoncrawl


text:
Coșul este gol!
This is the story of Clyde Griffiths, who spends his life in the desperate pursuit of success. On a deeper, more profound level, it is the masterful portrayal of the society whose values both shape Clyde's ambitions and seal his fate; it is an unsurpassed depiction of the harsh realities of American life and of the dark side of the American dream. Extraordinary in scope and power, vivid in its sense of wholesale human waste, unceasing in its rich compassion, An American Tragedy stands as Theodore Dreiser's supreme achevement.
Based on an actual criminal case, An American Tragedy was the inspiration for the film A Place in the Sun, which won six Academy Awards and starred Elizabeth Taylor and Montgomery Clift.
With an introduction by Richard Lingeman and a new afterword by Margaret E. Mitchell.
dreiser theodore


text:
sharond MySecret6987 roguedick rachael_b HotToTrott scarlet101 paulinarubia deviantpair000 juno44 banana_hammock just4fun1000 sintia Rkmurr ginag25 sarahanchris ritaben33 cyphrelost baddboyrising DandG JillInIndy chad89 luvmelongtymepl jazzymommag bimbo_ela couples4fun erotic007 adamforfun Cacalac sarasultriss chrisjelly sweetme84 PARASTUR1989 77dogs Isabel micandlys knightslady tgpaula cumsuker1c852 Hornycouple17 Tom5233 sekme15 hucky1955 switcherdawna divinegoddess66 ChicagoCD 1fungrl4u thetwofous1971 luvulongtyme14 Veronica_Faye Remee Spanksalot69 mid_special_74 mandex Nitehex6968 JasB_CA ladymagikwolf
Male, 31 United States
Michigan, USA
2,592 mi from you
Click to enlarge
Body type:
5' 5"
A few extra pounds
Erotic chat/email, A discreet relationship, Casual sex, A long term relationship, Just penpals, Phone Chat, Friends
Women, Couples
Everyone wants to know as much as possible about a potential partner. Tell other members more about yourself by filling out the multiple choice questions in the sections below. You can change your answers anytime. When you have completed a section, your profile will get a tick next to that category so others will know you're taking your search seriously.
These enhanced profiles will give you a much better insight into nmb413's lifestyle, desires, fantasies and more. Click on any of the links to open a new window and view nmb413's answers to questions on the following topics...
Anyone Looking to Take My V-Card
Men Seeking Women
I'm a 24 year old male, blonde hair, green eyes, and a little bit of extra padding, lost 20 pounds since January (185lbs) Still a virgin and looking to find idea a older woman to teach me a few things. Feel free to write ma and I'll send you some pics and we can take it from there.
I'm willing to just have fun, and if it turns into something more cool, if not that's ok too. Really I'm looking for friends with benefit's type situation.
I'm working and going to school still and not looking for a sugar momma, just somebody who is fun.
Remember that an ad ....
Other members...
Random Thoughts......
Just random thoughts about life, sex, and anything in between
Click to rate this blog: 1 2 3 4 5
My First Story
Friday, June 1, 2012
We decided to go on our first date, I know you said you wanted to go on a date where you wanted to dress up and look real good. So I planned us a date at nice fancy Italian restaurant near you so you'd feel comfortable. I told you and you seemed excited for it, and we set the date, and we talked like we normally do up to the date.
The day of the date gets here, and I decided to go with a pair of black suit pants, with a burgundy dress shirt, with a black and red tie. I got in the car and drove up to you see. It seemed like the longest trip there because I really wanted to finally meet you.
We decided that I would pick you up, and take you to the restaurant, So I got to your house and knock on the door, and you open the door wearing a sexy red dress. You looked just incredible in it. I could barely get the words out, but I was able to spit out, "God, you look amazing". You just smile, and we headed to the car.
We get into the car and we made small chit chat, until we got the restaurant, Once we get there I get out, and walk to the other side, and open the car door for you, and help you out of the car. We head in for dinner, and we had great time, we talked about everything and anything. We were there a couple hours, and it was time to head back.
Once we get to your house, you ask if I wanted to come in, Of course I said yes. So you usher me into the house, and tell me to sit down on the couch, and you would get us something to drink. You come back and sit down next me and we start talking again. In middle of conversation, I just go for a kiss. It was amazing, and we started to make out on the couch. I start slowly rubbing and down your leg. After were going through passionate kissing, I tell you I want you so bad. You play coy and you make me say, "I want to fuck you badly."
It was a proverbial switch, once I said that, you hurried right to my zipper and unzipped my pants frantically. You reach in my pants, and grabbed a hold of my semi-hard cock through my boxers. Then you squeezed it nice and hard, and you look up and me and smile. You sink to the floor, and spread my legs open, and your inch your way in between them. You unbutton my fly of my boxers and you take my cock out. My hard knob staring you right in the face as you get down and you tease my cock.
You slowly kiss the head of my cock, and all the way down the shaft. Then you start running your tongue up my shaft to my head. You stop and run your tongue up and down the slip, and then you lick back down the other side of my shaft. Then you slowly start stoking it, as you look at my face. Then you start leaning towards my cock, and you start to suck on it. It feels amazing. "Don't stop baby." Boy you didn't either, you just kept sucking my cock like a champ. I tell you to stop because I know I'm just about to blow, but right before you stop you give my cock one more nice long lick.
Once you get up, I reach up under your dress, and tell you I want to cum right here, as I slowly rub your pussy through your panties. You just let a slow moan out, as I feel your panties moisten up for me. You step back, and slowly strip for me taking your dress off, as your just in your panties. mmmmm is all I could muster to say. Then you slowly walk over to me and I slowly start suck your tits. Running my lips over your nipples as I playfully nibble on them. At the same time your standing there with your hand deep in your panties rubbing on yourself.
When I stop that is when you slide those soaked panties off for, I take a hold of your hand that was buried in between your legs and lick the juices off. Then you push my head back and I'm sitting on the couch with my swollen cock out of my boxers, that's when you come over and straddle me. You position my cock to your pussy, then you hold onto the couch and slowly slide down on my rock hard cock.
Thats when you start riding me nice and slow, see your titties bounce up and down in front of my face. I take my hands and hold onto your ass. Then you start riding faster and faster like a woman insane. Then you shimmer back up my cock, and you bounce down hard on my cock, you do that a few more times. The sensation of you shimmering, and riding my cock hard has me in pure ecstasy. You look me dead into the eyes and tell me I need you to fill my cunt up with your cum. Then you ride my cock harder. After a few bounces you try to shimmer back up my cock, and I push you back down, and I buck up into you and I explode inside you. I see your eyes roll back in your head, and I feel some your warm liquid start to run down my cock as you cum instantly.
You lean down and we start to kiss some more. You whisper to me and tell me lets go to bed.
Your first time?
Wednesday, May 30, 2012
If you read my profile you'll no I'm still a Virgin (24 years Old).... Sad I know, I'm shy and normally I clam up once I get close to sealing the deal sort of speak.
The question is how was your first time? Was it what you thought it was going to be?
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Other people you might be interested in


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This is going to short and to the point. If you've read my earlier post on using coupons, some of it may sound familiar, but some of the suggestions are so simple they're worth repeating. And they'll help you save money on groceries.
First and Easiest
Danielle Wagasky knows from firsthand experience. She managed to stretch a $14,000 annual income to cover her family of four's expenses over a period of five years. She's written a book about it, "Living a Beautiful Life on Less".
Her first admonition is don't shop on an empty stomach! If you go into the store without having had even a small snack before, everything is going to look delicious. Snack foods (chips, crackers, cookies, pastries) all jump out at you and before you know it, they've landed in your buggy. It doesn't have to be much; a small sandwich, a cup of soup. Some people can even get by with a cup of hot coffee.
"If you go hungry," says Wagasky, "you are just begging to have a cart full of guilty-pleasure foods. You can't make a week's worth of meals out of those ingredients, but you can wreck your budget by purchasing them when you don't need them and can't afford them."
Your checkbook will be fatter, but your waistline won't.
Numbers, Please
Use a calculator as you put each item into the cart, (at least, the shelf price; there might be discounts ahead that will only make things better).
Wagasky explains. "You are more aware of how much each item is adding up. You suddenly weigh the options a bit more with name brand versus generic. You think twice about adding all that candy into the cart just because it looks good. It makes you more conscious of what you are tossing in."
If you don't want to carry a calculator with you and don't have a math wizard as a child who accompanies you to the store, most phones these days have a built-in calculator. Practice and then use it!
In-store Traps
Don't shop during lunch hours. Many stores have cooking demonstrations with chefs whipping up fantastic dishes out of their special items. They smell tantalizing, they'll offer you a valuable coupon, and before you know it, you've dropped a $14.95 package of ribs into your basket. If you want to do a "taste test," do it after you've checked out. The "big box stores" are notorious for this, and especially on Fridays.
You may not realize it, but stop and think. Most grocery stores are, generally, laid out the same way – produce, deli and specialty items are to the right as you enter. The meat and dairy are at the back of the store, and chips and snacks are located at the furthermost left point of the store. Why do they do that?
Think about it. Most produce, deli and specialty items you select are impulse purchases. If you are going in with a set budget amount in mind, that's been knocked for a loop after a few fresh veggies and some deli snacks.
You have to pass a lot of end-cap special offers to get to the meat and your necessary dairy items like milk and cheeses. And with all those chip choices facing you in one place, it's hard to only pick up one package. Break the power of the planners; get your cart and go to the left, reverse your usual route through the store.
Try to block out the "music" on the PA system. It's been selected and scheduled to lower your resistance. There will be some dreamy sounds that take you back to "another time and place" where memories of special meals and times will influence what you buy. I don't advocate wearing headphones, but try to tune out the tunes.
Family Matters
If you can avoid it, don't take children to the store with you! They can spot a prize or toy offer on a box a cereal at 40 paces. They also can't make up their minds about what cookies they want, or what candy bars they want in their lunches.
Get input from everyone about what goes on the grocery list, then stick to the list! If you want to go to the trouble, you can estimate all the prices on it, and have an idea in advance of how much you are going to spend. The trick here, though, is to get everyone to participate in putting the list together. Put a pad or chalkboard on the fridge and encourage the listing of things on it. Nine times out of ten, if you delete an item as unhealthy or unnecessary, by the time you unpack things, they'll have forgotten they even asked for it anyway.
Pay by check, not credit card. That brings it home to you faster of how much you've spent. And, to put a few pennies back into savings, ask the checker to give you the amount before any coupons or discounts, but after tax (don't worry about that; the checkout system will always tax you on the higher amount anyway). Write the check for that "before" amount; take the change as cash and put it into your savings box.
Change your habits. Get the grocery ads as early as you can and strategize your shopping plans. If you need specific items, find out which store has them on sale this week. Got there for just those things.
Avoid shopping on the weekends; you'll feel too pressured to cave in to the impulse items on sale amid all the hustle and bustle of the crowds. If the store's ad schedule permits it, a nice quite Thursday evening is best.
Do you have any tips and techniques to use to keep your grocery costs down? Have you tried any of these? Do they make sense to you?


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Join owner of Tonic's Nicci Sylvester for a fun & informative session on fresh juicing and how good it can make you feel and look. Enjoy several fresh juice combinations while learning what to combine & how much for optimal health. 11 am speaker on Saturday. Conference runs 9am Saturday and ends with a closing ceremony on Sunday from 3:15 - 3:45pm.
The event wishes to provide a supportive & nurturing setting for a dialogue of caring and mutual respect between & among woman & men from many spiritual traditions.


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Partnerships need to consider new U.S. tax representative role
By AdvocateDaily.com Staff
With the recent introduction of new partnership audit rules that set out who can represent a business before the IRS on tax matters, now is the time for partnerships — both U.S. and foreign — to act proactively to ensure they comply with the strict requirements of the new role, U.S. tax attorney (NY, DC) Alexey Manasuev tells AdvocateDaily.com.
Last August, the IRS finalized the proposed regulations, requiring any foreign or domestic partnership that is subject to U.S. tax, with limited exceptions, to appoint a "partnership representative," who will be responsible for communicating with the IRS on any audit or tax matters, effective from the 2018 tax year.
"Partnerships that are required to file their tax returns by March 16, 2019 will be affected by this new regime, and it's quite a significant development," explains Manasuev.
The new role replaces the former "tax matters partner" that partnerships were required to appoint in earlier tax years, says Manasuev.
"The tax matters partner would sign the tax return on behalf of the partnership, deal with the IRS and other partners in case of an audit and other inquiries and matters involving the IRS. Generally, anybody could have been a tax matters partner — it could have been a business entity, it could have been an individual partner," he adds.
But while the partnership representative's role is similar to the concept of tax matters partner, Manasuev cautions that the new regime carries much stricter conditions for who can fill the role.
"To be a partnership representative, either an individual or a business entity will have to meet certain requirements. First, it must be a person who has a substantial presence in the United States."
"The representative must make themselves available to meet in person with the IRS in the United States at a reasonable time and place. That determination is based pursuant to the Treasury regulations which deal with examination and how the IRS conducts its audits. Sometimes the IRS auditor may visit the taxpayer at their location, or may require the taxpayer to appear at the IRS office, and so, generally speaking, to be available to be appointed as partnership representative, the person should at least have the ability to enter the United States," says Manasuev.
In a Canada-U.S. context, he adds, arguably, the partnership representative should have a U.S. work visa, as when they are representing the business before the IRS on an audit or tax matter, they should be considered to be working in the United States.
Furthermore, the partnership representative must have a U.S. taxpayer identification number, says Manasuev.
"A foreign partner in a U.S. partnership or a foreign partnership with U.S. source income or income effectively connected to the partnership's U.S. trade or business can apply for an Individual Taxpayer Identification Number (ITIN) if an individual, or Employer Identification Number (EIN), if a business entity," he says.
The individual is also required to have a U.S. street address and a telephone number with a U.S. area code.
Although partnerships are permitted to appoint a designated individual to serve as the partnership representative, and several businesses in the United States offer these services, Manasuev notes that there are limitations in place.
Businesses also need to keep in mind that the partnership representative role carries a lot of power and responsibility.
"What is critical about the partnership representative's role is that the person has the authority to bind the partnership and the partners on an audit and that authority is pretty much absolute," he says.
"While selecting the partnership representative, taxpayers should really pay attention to who they select, to ensure that they don't run into any issues because, if in the future, they are audited and, for example, the partnership representative enters into a settlement with the IRS, that settlement will be binding for the partnership and the partners," adds Manasuev.
Although finding a partnership representative that is the "right fit" will be key, Manasuev says the critical area for most businesses at this point is simply knowing about the requirement.
"Some tax preparers may not be aware of this requirement. And the tax advisors really have a job of making sure clients are protected, alerting their clients to this issue and acting proactively, because if everybody realizes it on the day they need to sign the partnership (Form 1065) return, then they may have to extend their return, or they may file it without this critical piece of information," he adds.
"It is uncertain at this point whether a partnership return without a partnership representative may stop the statute of limitation from running. But it is possible that a partnership return without a partnership representative or with a 'partnership representative' who does not meet the IRS requirements, may be considered incomplete. This could result in the tax year to be open," says Manasuev.
Ultimately, Manasuev says the IRS will not discuss tax matters involving the business in the absence of the partnership representative.
"This is the time when people should pay attention, taxpayers really should be thinking about this, and more importantly tax return preparers and U.S. tax advisors should be bringing up this issue with their clients," says Manasuev.


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18740 Main Street
Tontogany, Ohio 43565
Pastor's Phone 419-806-4326
office hours by appointment
Church Phone: 419-823-7591
Email Address: firstname.lastname@example.com
18740 Main St., P.O. Box 126
Tontogany, Ohio 43565
We support the Otsego Food Pantry.
If you are in need of assistance, you are invited to call:
Rev. Pamela Short
Phone: 419-806-4326
Email Address: email@example.com
Sorry! No regular office hours.
Feel free to call Pamela Short for an appointment.
Pamela comes from a farm family in Fulton County, Ohio. She had the privilege of practicing nursing for 25 years and teaching World Religions for 10 years. Pamela was raised in the Evangelical Mennonite tradition and graduated from the Associated Mennonite Biblical Seminary in 2004. She migrated to the Presbyterians in 2011 and finds her community of faith in Tontogany to be welcoming and encouraging. "I am continually challanged by the People of Prayer at Tontogany to grow into a deeper life of communication with God."
Pamela seeks to ground her preaching in the Scriptures. "My understanding of a sermon is that the preacher is retelling God's story of love for all. When after study and pondering, I am still left with a blank page, the Holy Spirit reminds me, 'Just tell the story'".
Elders serve on what Presbies call "The Session".
The Session is responsible for varied and sundry ministries within the church.
Feel free to contact our Session Elders to learn more about our community of faith:
Margy DeLuca, clerk of Session, email@example.com
Judy Robinson, firstname.lastname@example.com
Donna Lambert, email@example.com
Lee Seeger, firstname.lastname@example.com
Louie Pauff, email@example.com
Anne Moser, email@example.com
Patti Wires, email@example.com


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Tanna MacReynold, special projects manager of the Institutional Review Office at Fred Hutchinson Cancer Research Center, and an active PRIM&R member, recently spoke with PRIM&R about her decision to apply for the CIP® credential and her experience preparing for and taking the CIP exam.
PRIM&R staff (PS): PRIM&R members are interested in learning more about the value of professional certification. I wanted to ask you a few questions about why you decided to make the investment in obtaining the CIP credential, and then about how you prepared for the exam.
PS: When was the first time that you took the CIP exam?
Tanna MacReynold (TM): The first and only time I have taken the exam was in 2005.
PS: What prompted you to take it?
TM: I had been working in the field for over four years; I had attended PRIM&R's national conferences where I talked to people about the credential, and I began to see value in having the CIP®. In addition, my office was about to start the AAHRPP accreditation process, and I was encouraged to take the exam as a way of improving our program.
PS: Did your employer ask you to take the CIP exam?
TM: No, they did not require it, but they did encourage me to obtain my CIP.
PS: Did you think that having the CIP credential would help you to advance in your job?
TM: Maybe not in my particular situation, but as a general matter, yes. My colleagues and I are seeing an increasing number of job descriptions noting a preference for applicants with the CIP credential. Having CIP credential is not a requirement for working in my office, but those who pass are reimbursed for the application fee.
I also found the credential useful in other, unexpected ways. Our office recently developed enhanced software for IRB administration which we have sold to other institutions. I believe that we will have more credibility with potential customers when we tell them that the software was developed by people who have the CIP® credential, and possess this level of regulatory knowledge.
PS: Does your employer recruit people who have the CIP credential?
TM: The CIP is not a requirement, but we do indicate during recruitment that candidates who possess the CIP credential are preferred.
PS: Does your employer pay a higher salary to those employees who have the CIP credential?
TM: Well, there is no guarantee that if you pass the exam you will receive a salary increase, but it would certainly be a relevant consideration in a salary review.
PS: Now I would like to shift our discussion to what strategies you used for studying for the exam. How long before the test date did you start studying?
TM: Generally speaking, my years of experience working in the field were the most helpful background for taking the test. Once I made the decision to take the exam and submitted my application, I began studying in earnest which was about three months before the exam date.
PS: Can you tell me a little bit more about your background and experience working with IRBs?
TM: I have four years of experience working as an IRB Administrator and Analyst. I have experience supervising other analysts and administrators and was eventually promoted to Assistant Director by the time I took the test. I conducted the human subjects training for my institution which was very helpful to me as I prepared for the exam. I would recommend that anyone considering taking the CIP® exam retake the formal human subjects training provided by his or her institution, or even better, become a trainer for the course.
PS: What materials did you use to study?
TM: I read and reread both the HHS and FDA regs. I also found the IRB: Management and Function textbook and Study Guide helpful. I started with the Study Guide. I tried to answer the questions, noted my deficiencies, and then read the text book cover to cover. I also reviewed the Belmont Report, the Declaration of Helsinki, and the Nuremberg Code. It is important to learn how to apply these principles. The CIP Handbook is useful and so is the text Protecting Study Volunteers in Research. It is also important to review the FDA Information sheets and OHRP Guidances.
PS: How did you find the time to study while you were working?
TM: I would study about five to ten hours a week in the beginning and then, during the last two weeks, I used all of my spare time to study which probably amounted to about 30 hours a week. You have to know your study style. I hadn't taken a test since the 70's! I tend to be a "crammer." I took a lot of notes, and then reread and highlighted them. Another strategy that might be useful for some people would be to record your notes into a dictaphone to listen to while commuting or doing other activities.
PS: How did you decide which areas of content to focus on?
TM: Using the Study Guide to figure out my weaknesses helped me to prioritize. I also tried to focus on the areas unrelated to my own work. I had to spend a lot of time learning about pediatric and emergency research issues which I do not regularly deal with in my current job.
PS: What final words of advice would you like to offer people who are considering taking the CIP® exam?
TM: I guess I would say to talk to other people who have taken the test, and when preparing, focus on learning how to apply the ethical principles and regulations. Also, remember that your own institution's practices may not always be equivalent to what is required by the regulations. It is important to know the difference between what is required by your own institution and what is required by the regulations and ethical principles that are the focus of the exam.
PRIM&R thanks Tanna for sharing her experience with our members.
Download the CIP Handbook
Phone: 833.333.4755Email: firstname.lastname@example.com


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Some of this stuff would deprecate so quickly it'd be worth more as scrap, some simply wouldn't sell at all. Most of it your significant other half wouldn't allow it in the house.
Audiophilia madness/ pics or posters
The Jeff Koons rabbit sold for $93 Million a few months ago.
Agreed ridiculous price, but it still looked like a rabbit.
Ok maybe not
I'm pretty much in agreement with you here. If I could have the whole system invisible, I'd do it. The nearest I can think of that's achievable is to have nothing but a pair of speakers and a wireless access point in the listening room, and the rack hiding in a storeroom.
I did that with a new home in 2002 time frame. Plasma display above the fireplace, Yamaha av receiver, dvd player etc. hidden in a cabinet, 5.1 surround with front and rear speakers as in-wall flush mounts. Subwoofer. Programmable unified remote control. In a big 20 feet x 20 feet room.
It was awful in every way.
Not exactly what I had in mind!!
i hide also the tv stuff, router, …but i like to see my system components. It's my audiophilia weakness i suppose.
Good grief. The world's gone mad.
This stuff probably has a wow factor for a bit and then after a while it just look silly. A black box can just blend in.
the people who buy that are often changing their decoration, stuff…like normal people their shirts.
What redecorating every month?
the sofas, paintings, tables, hifi stuff… cars…
Yes, changed my mind. Marvellous.
a good advertising for the Mcintosh 1200w mono power amps. Probably some Dubai crazy rich man will install that in his house, with some tigers walking around the speakers.


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In accordance with Transforming Journal, the scale and scope of your kitchen remodel could make a serious difference—not solely in initial price however in the amount of cost that you just're likely to recoup in terms of added worth. Likewise, it will make working with kitchen transforming contractors simpler once you're able to get started. As a homeowner, the next question you must ask when planning for a kitchen transform is how lengthy you plan to stay in your home from the time of the transform. Bath, Kitchen and Tile Heart at the moment works with owners in MD, DE, NJ, and PA and has been in business since 1963. Ekestad cabinets from Ikea, quartz countertops and a ceramic glass induction cooktop made this a sleeker kitchen. Reply: Lowes, Home Depot and different home improvement shops sell cabinets and far of what it's good to remodel a kitchen.
After the work has been completed in prefab homes, it may be shipped from the manufacturing facility to the building web site and likewise there possibility of harm while delivery it. Depending on how far the modules must journey the transportation price will likely be high.
Backsplashes, kitchen Island walls, lavatory backsplashes, bedroom partitions, laundry rooms etc. Of course, kitchen remodels are also probably the most complicated and may be the most expensive. The risk with a kitchen transform that's designed to spice up your house's selling value is that you simply may spend more than you get again if the renovation does not increase the house's market worth by a lot.
The Ikea base cupboard below the cooktop options three full-extension drawers that hold utensils and pots and pans. The worst factor that can occur is being stuck with a kitchen that's 80{95557cfba7c8e53d4240af02a6da8379adbd73438ea32c73f5607ac839db7977} completed since you ran out of cash. In summary, a do-it-yourself remodel is estimated by cupboard costs plus countertop, home equipment, plumbing and electrical elements, permit prices, and TIME you spend doing the work and dwelling and not using a kitchen whilst you do it.
It appears amazing to me that such a tiny little kitchen may find yourself costing a lot. For extra information about kitchen transforming prices, call (800) 211-8394 or contact us to talk with a consultant. The common cost of a kitchen rework in Studio Metropolis is roughly $18,900 to $37,900. Put in, the large, glass subway tile appears to be like more inexperienced-gray, however it provides important shine and polish to a very minimal kitchen design. It's also possible to choose from a wide range of other materials with enticing colours, textures, and patterns that may deliver a more cohesive look to your kitchen.


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The Music in Speech
Living in a multinational city you get to hear all sorts of wonderfully musical accents. This podcast by Twenty Thousand Hertz goes into detail about The Music in Speech.
credit 20k Hertz
The Sound of Blade Runner 2049
"In this exclusive video profile we feature the sound team behind Director Denis Villeneuve's, Blade Runner 2049 featuring supervising sound editor Mark Mangini, sound designer Theo Green, re-recording mixer Doug Hemphill and Ron Bartlett, picture editor Joe Walker and Composer Hans Zimmer and Benjamin Wallfisch."
- credit SoundWorks
How to Sound Design Your Life
Storytelling With Sound
Andy Saladino's brilliant video essay on Sound's role in Storytelling. Including an invaluable concept to approaching sound design by my idle Ben Burtt. Check it out below
Patatap - Superb blend of Music and UX
Use this to get yourself into a creative space and irritate your coworkers.
Made by the folks at patatap.com


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About Us
Pure Vapor Bliss is located in Rocky Hill, CT. We are a Family owned and operated store. Our journey started when a family member, smoker of over a pack a day for 30 years, came to visit. She had quit smoking and was vaping! This was something very foreign to us here in New England, but intrigued us with her success and how much healthier she claimed to feel. So with that we did research, my daughter, a pack a day smoker, bought a vaping starter kit . She hasn't smoked a analog cigarette since. She feels much healthier, free of the bad taste in her mouth and lingering smoke smell on her clothes. She is free to vape just about every where she chooses.
This has been a freeing experience for her and our family. One we feel should be shared with everyone who feels trapped in the cigarette world.


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I took my guitar to Matt at Salt Mine Repairs after it had been through the hands of a few other guitar repairers. Matt immediately struck me as doing things differently by the number of questions he was asking me. He wanted to get to know my guitar, what its problems were and what I was looking for that guitar to be. It felt like a consultation with a health professional and I really appreciated the thoroughness of it all.
Apart from an extraordinary subject knowledge Matt has a forensic mindset. He was determined to find the source of the problems of playability … and he did. Matt was proactive with repair solutions and consulted me at every step of the way. He gave me sensible choices/options and was more than happy to discuss any queries or concerns I might have had.
- G. Hughes


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There is no doubt that Hurricane Irma caused much damage to the state of Florida, and created a tremendous amount of stress, anxiety and concern for its citizens and visitors alike.
We sincerely hope that everyone stayed safe during the storm, and have since been able to get in touch with your loved ones.
Moreover, we owe an enormous debt of gratitude to our devoted team members who worked tirelessly and selflessly to ensure the safety and wellbeing of our residents. The way in which we all came together to prepare for and respond to Hurricane Irma strengthened our team and resident bonds even more so.
Now that the storm has passed, the Sabal Palms family is looking forward to sunny skies ahead! We are happy to have returned to our daily activities as normal. We would like to extend a thank you to all family members, friends and others for checking our updates on the website and Facebook page during the storm, as well as your patience.
During natural disasters as well as the everyday, we are dedicated to providing residents with support, care and services, ensuring their safety 24/7. If you have a friend or loved one who may be interested in our community or require additional care, we invite you to contact us directly at 727-586-4211.
The safety and well-being of our residents and employees is our highest priority. We have a comprehensive emergency preparedness plan in place, and are equipped with water, food, permanent or temporary generators, and supplies. Appropriate actions are being taken and will continue to be taken in order to keep everyone safe as we watch the storm closely. Our leadership is in close communication with our management company's executive leadership team. Directions provided by local and state authorities are being monitored and will be followed as instructed.
For the latest weather information in your area choose one of the links below:
Latest updates in response to Hurricane Irma will be posted on this page. If you have any specific questions, please call our community at 727-586-4211.
Friday, September 15th @ 3:10pm EDT.
Sabal Palms has been fully operational now for more than 24 hours. This will be our last update. We would like to extend a thank you to all family members, friends and others for visiting this page for updates, as well as your patience. Please contact us directly with any further questions.
Thursday, September 14th @ 12:10pm EDT.
We happy to report that the phone lines at our community are currently in the process of being restored. We hope our communications will be fully operational by end of day.
Wednesday, September 13th @ 1:25pm EDT.
Note from our Executive Director, Mark Moyer: We continue to wait for phone lines to be restored. Otherwise, all is good and again, the team is nothing less than amazing.
Tuesday, September 12th @ 10:35am EDT.
Note from our Executive Director, Mark Moyer: We are happy to inform you that power has been restored at our community. Our generator ran throughout last night. Telephone and data communications are still down, and cell phone coverage is spotty. We have calls placed into the telecommunication companies to check our status. We appreciate your patience as communications are restored.
Monday, September 11th @ 4:52pm EDT.
From our Executive Director, Mark Moyer: I am pleased to report that we have adequate staff, and everyone remains safe and content. We are currently still running the generator and phone lines are down. Would like to share with families that generator is being used to power essentials, such as air conditioners and other equipment. Charging cell phones comes as a second priority. We will keep families updated as often as possible through website and Facebook updates.
Monday, September 11th @ 5:13am EDT.
Note from our Executive Director, Mark Moyer: A band of heavy rain and high winds have moved in as storm tracked back into Tampa. We still have power. We have seen just a few leaks around the building. We are blessed that all are safe. Our Department Heads, Nurses, Dietary Maintenance Teams and all other team members have been truly amazing.
Sunday, September 10th @ 5:05pm EDT.
Note from our Executive Director, Mark Moyer: "Some wind and rain at this time. All remain in good spirits and all is calm. We are fortunate to be well staffed with our dedicated team members. Sabal Palms will be on lockdown at 6:00 p.m."
Sunday, September 10th @ 11:20am EDT.
Saturday, September 9th @ 10:00pm EDT.
Saturday, September 9th @ 3:00pm EDT.
Friday, September 8th @ 2:27pm EDT.


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Exceptionally easy to operate, these shutters are specifically designed to minimise maintenance and reduce workload, while keeping fitting times to an absolute minimum.
Available with a wide range of lock options and tailor-made security systems, all 57 shutters can be modified to suit the needs of your requirements, keeping your fleet ahead of the game.
Roll Shutter Features
- Close fitting curtain
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- Positive stop brackets on bottom rail
Roof Shutter Features
- Top is fitted with neoprene seal to close against header
- One-piece tracks incorporating radius bends
- Close tolerance waterproof slat profiles
- Pre-tensioned operator with simple adjustment
- Interlocking nylon end shoes
- Internal twin cables for efficient lift
- Galvanised channels
Component Gallery
57MM Gallery


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1. MIZUNO: How did you become a triathlete? What fascinates you about the sport and what does it give back to you?
JGN: I come from the swimming field. When I was a kid I trained and raced with the swim team of my hometown, Ferrol. At that time some triathletes came to swim at the same pool. They knew I was not like the other swimmers because I liked to run and ride for fun sometimes. One day, they encouraged me to go to a triathlon with them when I was 14. From that day I became fascinated with this sport which has given me everything; my friends and my social life are all around triathlons. It is a kind of lifestyle, because at the end, from when I wake up until I go to sleep, I am 100% involved with the triathlon. I am in debt to this sport.
2. MIZUNO: Many people struggle to find enough motivation to exercise and improve in one discipline. In triathlons, you need to be excellent in three areas: swimming, running and biking. Do you need to train 3x as hard? Where do you find your motivation?
JGN: I think that training for three disciplines is more rewarding than just for one. It is obviously very demanding, but I prefer to do one session of each every day, rather than just be focused on one of them. For me, motivation comes naturally, triathlons are my passion and it has become my job. I feel lucky for it.
3. MIZUNO: You compete in many different competitions around the globe, don't you ever get tired/exhausted?
JGN: Yes of course, travelling is one of the key factors you have to face and must manage well, otherwise you take the risk of becoming injured. Flying, airports, and jetlag are also very tiring. They are some other factors of stress that make you busy.
4. MIZUNO: Your licence to compete internationally has been removed by the CSD not only once, but twice in the past. How did you bring up the strength and courage to fight this hardship twice?
JGN: At that time I was just a teenager that wanted to do what I liked, I was not thinking of being a World champion, winning races, etc. I enjoyed training as I do now. With that being said, there were some very hard and tough moments for me. The support of my family and my inner circle was very important to overcome the situation. Looking back, all the situations I lived through, made me mentally stronger.
5. MIZUNO: When thinking of Rio de Janeiro, most people think of the Copacabana and Carnival. What do you think of when you hear the word?
JGN: I think of Copacabana as well, because the triathlon will be hosted there, but not of the Carnival… haha. Rio is the main goal of this year, I am putting all my efforts into this race. Anyhow, nowadays, I am hearing this word "Rio" too many times, everyone reminds me repeatedly, encouraging me for the preparation, the race, etc. This is when you realize that the Olympics are different to any other race, many people even out of the sport, know about the Olympics.
6. MIZUNO: How do you prepare for Rio? Are you making any changes compared to your preparations in 2012?
JGN: Yes, I will probably race less than in 2012 before the Olympics. Rio is a different race course than London, the bike section has a steady hill, added to the humid and hot weather conditions we might find in Rio in August, the race will probably be different. I do not expect the running course to be as fast as we did it in London due to the demanding bike course; therefore you have to be very solid in the three disciplines to win the race.
7. MIZUNO: Do you have a pre-race routine that you go through before an important race such as Rio?
JGN: My pre-race routine is always the same for every race; I like to swim, bike and run a bit before the race, having the last meal 4 hours before the race time start.
8. MIZUNO: Imagine yourself standing at the starting line in Rio. What will be on your mind?
JGN: I will probably be very focused on the swim start horn, so I can be concentrated on swimming very fast until the first bouy. In a triathlon you can lose the race in the first buoy if you are not well located and the swim is fast, then the race can be broken, if you are not in the leading group, the medal options are over.
9. MIZUNO: You've won more or less every important international triathlon title already – except for Olympic gold. Is this the ultimate goal? What will come after Rio?
JGN: No, it is not my ultimate goal, but it is the most important now. What will come after Rio I do not know yet, I have to think if I will keep my focus on Olympic distance, or jump to long distance races. Honestly, I do not know yet, but I am not thinking on it right now.
10. MIZUNO: What comes to your mind when you hear the slogan ''Never stop pushing"? What does it mean to you?
JGN: I feel totally identified with this slogan, it is the way I understand this sport, not just in racing, but even more importantly in the daily training. Obviously you cannot go 100% in every workout, but I believe on having a daily routine and making sacrifices; to wake at 6am, no pain no gain.


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Zulfiqar's loss is Kanwarpal's gain
Whistleblower Kanwarpal, 35, who once used to be a close associate of Zulfiqar Khan, nailed him with complete evidence of pictures and statements of children alleging sexual exploitation. It was rivalry of money and recognition that Kanwarpal and Zulfiqar ended up their association of the last two decades. But Kanwarpal says, he left Zulfiqar as he had seen him sexually exploiting a child.chandigarh Updated: Jul 14, 2015 15:06 IST
Whistleblower Kanwarpal, 35, who once used to be a close associate of Zulfiqar Khan, nailed him with complete evidence of pictures and statements of children alleging sexual exploitation. It was rivalry of money and recognition that Kanwarpal and Zulfiqar ended up their association of the last two decades. But Kanwarpal says, he left Zulfiqar as he had seen him sexually exploiting a child.
Kanwarpal, hailing from Saharanpur in Uttar Pradesh was brought up in Chandigarh. His father, a sweeper at a city hotel, and mother a creche worker died when he was a teenager.
Brought up in the jhuggis at Sector 25, Kanwarpal said, "I never knew what an NGO meant, till I met Zulfiqar. But since childhood, me and my friends (a group of about nine) always wanted to do something different for the society. We would clean up our area and help the children in studies."
Kanwarpal worked as a rickshawpuller, labourer and even sold fruits. Now, Kanwarpal heads an NGO Education first, which he constituted in 2013, after parting ways with Zulfiqar.
Kanwarpal, who was once introduced to the world of social service by his only inspiration Zulfiqar Khan, has floated an NGO just on the lines of Theatre Age. Zulfiqar, had also helped Kanwarpal get married to a girl who was associated with Theatre Age.
Kanwarpal is also into collecting newspapers, waste material, books and furniture in the form of donations from city residents. He runs the NGO from two rented rooms at a small house in Sector 25. He teaches children and also has small vans to collect waste newspapers for making creative things out of it.
Kanwarpal was just 12, when he first came across Zulfiqar, who was 15 years elder to him. Talking about good old days in 1991, Kanwarpal said, "Zulfiqar used to play with us every evening and after a month, asked us if we watched TV and like to act in nukkad nataks."
Kanwarpal said the entire idea sounded interesting and nine of them started acting in street plays. "I can never forget the first time we saw our picture in the newspapers. We were so elated and displayed our picture like crazy all over the colony. That was our first experience with fame."
"Finally, we got the NGO registered in 1992 and gave small letters along with application that we will never leave Zulfiqar and continue working with him till we die," he added. "After displaying the nataks, we also used to seek donation sitting in open by spreading a sheet on the floor," he said.
Gradually, we improved from street plays to stage plays. We were majorly into theatre and finally got a room at Sector 24 government school in 2002 and added up to eight rooms till 2013. Among the old associates, I was the only one who continued till 2013 and others had left Zulfiqar one by one. Only one woman out of the old associates is still with Zulfiqar.
Kanwarpal used to manage students at the school and was responsible for getting the newspapers donated by city residents. All was going on as usual and on one fine night in 2013, I went to ask for some money from Zulfiqar at his Sector 25 house. As I went up the stairs and opened the room that was not locked from inside, I saw him doing unnatural sex with a child. I immediately rushed down and under shock I did not talk to Zulfiqar for about a week. Before quitting, I questioned Zulfiqar about the same. He replied: "Your work is to collect scrap and keep doing it without questioning me."
"I stopped working for him and gathered like-minded people and floated my own NGO in 2013 to keep communicating with people in the society. I wanted to bring out the truth of this man," he added.
"Mein apne baap ka bhi nahin agar sachai ke liye khada hona pade. I know my life is under threat as Zulfiqar, a day before his arrest, had thrashed me at my home," said Kanwarpal.
Kanwarpal says his house has been running with the income of his wife who has been working in a private school for the last 10 years.
"I know, I can be killed anytime for exposing a man with so many links like Zulfiqar. I collected evidence and then approached the police after two years," he said.
First Published: Jul 14, 2015 15:00 IST


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underwriting case manager
The President and CEO is currently seeking a proactive and highly organized project manager to direct the underwriting process for new and existing business for the Company.
This Underwriting Case Manager will be an integral player in closing revenue for the Company, responsible for gathering, analyzing and submitting required documents in a timely manner. This person must have a sense of urgency, professionalism and eloquence and must have a "do what it takes" mentality when it comes to client service. The Underwriting team is responsible for providing the knowledge and resources to those sources to deliver an outstanding experience for our clients and partners.
We are seeking a self-starter who is passionate and energized about project management, client service and iterating on processes to create efficiencies. This person will oversee multiple cases at once and must be able to juggle many plates in a fastidious manner. This is a fast-moving organization and at times, results in stressful scenarios with temporal and financial consequences. This individual must be anticipatory and must have "thick skin".
This person will have immense opportunity to expand their role within the company based on their ability to manage the many activities and initiatives, speed at which they learn and level of performance of their duties. The Gottlieb Organization is launching into a phase of expansion and this individual will be a part of the initial stages.
Primary Duties:
The Underwriting team is responsible for processing, analyzing and submitting all requisite documents for our clients' insurance carrier applications in order to purchase large and complex life insurance policies. The role requires daily interaction with the CEO, national affiliates and internal teams to understand the case objectives + updates, meticulous collection of documents all while strengthening relationships with clients, medical offices, affiliates, and institutional partners.
- Learn the lines of TGO business and the TGO proprietary strategies, including but not limited to individual wealth financial planning, estate and tax planning, life insurance, risk management and asset management
- Frequently interface with CEO and internal teams to track development of new business. Learn each client's objectives and proposed case strategies. Stay up to date on prospective client meetings and keep detailed notes in database.
- Familiarize and stay updated with the insurance carrier application requirements. For abnormal cases, obtain and document new processes for TGO records.
- Guide the Client through the carrier underwriting process in a timely and professional manner reflective of TGO values.
- Review and analyze all client information to ensure accuracy and prevent issues from arising
- Collect and organize all information relevant to carrier underwriting process, including obtaining confidential information from internal teams, clients, affiliates and medical offices.
- Stay in constant communication with CEO, internal teams, affiliates and relevant third parties on status of current caseload.
- Maintain meticulous files, timelines and protocol
- Assemble and present final client package upon case completion
- Brief internal teams on the case; act as the 'go to' for all questions relating to the client, their background, objectives and case design
- As mentioned in this description, this person will be a part of initial stages of high growth for TGO; therefore, they will be expected to be in constant analysis of our processes and procedures, focusing on the quantifiable measurements of improvements.
- Not typical 9-5 job – either in orientation nor with time expectations. This individual is expected to arrive each day and be ready to work between 7:30-8:00am and generally depart between 6:00-7:00pm each day. Some days may be longer, some days will be shorter. At times, there will be extended hours or meetings on weekends as CEO often travels and needs time to catch up with his team.
- All duties not listed in this description
- Always asks questions - unafraid to show "I don't know"
- 3+ years of heavy project management experience within a team setting, managing multiple projects at once with various timelines
- 2+ years of daily interaction with high net worth or high-level individuals
- 2+ years of working with project management software, CRMs, and data warehouses
- Proven success with adhering to and improving upon process timelines
- Experience dealing with confidential information
- Clean data and diligent record keeping are incredibly important to you
- Knowledge of underwriting, compliance, insurance or financial planning a plus
- Bachelor's degree required, preferred fields in the areas of Business, Finance, Project Management or similar
- Able to function without significant structure but able to create structure
- Flourishes when tasked with cyclical work – always able to improve processes and set difficult goals
- Mastery of Microsoft Office products (Excel, Word, Office 365)
- Excellent verbal and written skills with superior grammar and attention to detail
- Unmatched drive to complete a project: motivated to follow up and follow through
- Detail oriented and intensely organized
- Can be excited about walking into a high-stress and fast-paced environment every day (a MUST)
- Cannot take criticism personally and highly coachable
- Able to take on multiple adhoc projects at once with tight timelines
- Incredible note taker, record keeper with meticulous attention to data and filing
- Fantastic health, dental and vision plan
- 401k match
- Paid garage parking
- Catered lunches at least once per week
- Work hard, play hard culture
- +more
Apply with your resume and cover letter to email@example.com addressing two of the following questions:
- How do you set and manage expectations?
- How have you taken a role and made it your own?
- Describe the most complex cycle you've ever improved.
- You've been assigned a short term project that requires other departments to complete it. How do you accomplish this project?
- What stresses you out in a workplace? How do you handle it?
- What added value do you bring to an office?


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Biofeedback Program
Biofeedback is a non-invasive treatment that increases awareness of physiological function through technological sensors that measure your heart and breath to track your stress levels in real-time.
Gradually with the help of a biofeedback clients learn to detect and control their physiological functions to improve health and physical performance. Over time change endures without the continued use of biofeedback treatment. Women receiving biofeedback treatment report increased motivation to take an active role in caring for their personal health and improved self-efficacy.
Symptom relief may include: increased attention and concentration, recovery from insomnia, a reduction in depression and anxiety, relief from chronic pain, and increased ability to manage and regulate physical stress.
Program includes biofeedback device. Initial and follow-up session required.
Initial Session $250 I Follow-up Sessions $135


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Sometimes power can go to your head.
We can certainly see this when the behaviour is exhibited by others. Have you ever worked with a peer in your team who was then promoted to a more senior position, only to end up seeing them release their inner tyrant? They suddenly get a taste of that power and before you know it, they have alienated all they work with. However this trait is less obvious when we turn our introspection inward.
When we speak to staff, what are the qualities that they say make the most influential people in their work environment. They certainly do not claim it is the people who shout, gossip, manipulate, berate or bully others. So what does positive leadership, positive influence and positive power actually look like?
We usually only see someone's external behaviour. We see them speak their mind, make necessary on the spot decisions, advance quickly within an organisation etc. But what is it that we are not seeing? Where is all that confidence coming from?
These influential people are focused and are driven by habits that they practice religiously. You can also practice these habits.
So what characteristics do influential people emulate?
They are mentally tough.
Mental Toughness is a personality trait that determines your ability to perform consistently under stress and pressure, and is closely related to qualities such as character, resilience, grit and perseverance.
Professor Peter Clough, Professor of Applied Psychology at Manchester Metropolitan University and a pioneer on research into Mental Toughness further describes a mentally tough person as "someone who is comfortable in their own skin, can take whatever comes along in their stride and mostly enjoy the challenge".
Mental Toughness isn't being macho or uncaring or self-centred – it is about being tough in the sense of not giving up and being confident that you can prevail, even if the odds are stacked against you.
Could you increase your Mental Toughness?
They don't wait for a title to lead
A title can give you authority, but it can't give you power. On the other hand, you don't need a title to be influential.
You can lead without being a boss and you can have a powerful influence upon your workplace and community without a title. Leaders can often tap into unofficial leadership potential. Encouraging this leadership is a huge advantage to the team.
They are never satisfied with the status quo.
They're graciously disruptive
They're the ones who constantly ask, "What if?" and "Why not?" A key element of Mental Toughness is a person's ability to see a challenge as an opportunity. They're not afraid of change or trying something different to make an improvement.
They think for themselves
An influential person is not swayed by public opinion and by what is popular. They can make up their own mind. They form their opinions carefully, based on the facts that they themselves observe and can see objectively. They have no issue admitting when they are wrong and to change their mind when the facts support a new direction.
They see conflict for what it is – an opportunity
Often people fall on one side of the fence or the other. They may be passive and avoid conflict at all costs, often backing down their position to avoid any disgruntlement from others. Alternatively, when faced with conflict, they behave in an aggressive way, locking horns with whatever other bull is willing to spar with them.
But a person with influence does neither. They do not let their emotions get the better of them. They often welcome difference of opinion as a wonderful opportunity to engage in meaningful debate and problem solving. They are humble enough to know that they don't know everything and that someone else might see something they missed. And if that person is right, they embrace the idea wholeheartedly, because they care more about the end result than being right.
Influencers inspire.
They know their strengths and weaknesses
People are often blind to their own weaknesses. To become truly powerful, you have to see yourself as you really are and to position yourself to use your strengths to enhance relationships. That means taking a clear-eyed look at your strengths and your weaknesses and owning them both completely.
There is strong scientific foundation to have a strengths focus. When we identify our strengths and focus on nurturing what we are naturally good at, we gain significant benefit. Research demonstrates when we use our strengths we are more confident, have higher self-esteem, greater levels of energy, are more resilient and are much more likely to reach our goals.
Using your strengths helps you to personally develop and grow. You find you are often more engaged at work and in your relationships.
Truly powerful people know how to make lasting connections.
They ask for help when they need it
It's easy to mistakenly assume that a person with influence never asks for help from anybody. But exactly the opposite is true. Asking for help when you don't know the answer is not a sign of weakness; it's a sign of strength.
It takes a tremendous amount of confidence and also humility to admit that you need assistance. There is nothing worse than going miles in the wrong direction, only to lament later why you didn't stop and ask for directions sooner.
They Visualise success
People with influence use the power of visualisation to see what they want to achieve. They believe nothing is out of their reach and their self belief generates powerful goal setting opportunities and they "stretch" themselves.
They firmly believe that one person can change the world. After all – isn't there evidence of this all around us.
They Don't put it off
If they can do it today, that's when it gets done. They don't wait until the right opportunity comes along, or second guess themselves. The only way to strengthen a muscle is by using it. So they do regular weightlifting of their goals and put them into action.
The only way you can exert your influence is to get out there amongst it. So you just need to convince yourself to "Go For It".
So consider - what habits could you start engaging in to exert your influence more widely? It may be worthwhile to start by examining your bad habits and consider how you could exert your influence in a completely different way. After all – the choice is yours.
Contact Michelle Bakjac on 0412047590 to consider goal setting to increase your influence.


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SIAM is seeking a creative, strategic Director of Programs and Services to support the technical activities of our organization. The Director of Programs is responsible for the oversight and management of programs and projects mostly concentrated on the society's membership and conference programs, including the administration of grants in those areas. Learn more.
Stop by the exhibit hall of the Annual Meeting Tuesday or Wednesday and explore the new SIAM website! We are excited to offer a newly-designed website which is now mobile friendly. Ask us your questions and tell us what you think of it. Your thoughts will be used to help guide future updates and improvements. With such an overhaul of our site, we are seeking reports on any bugs you should find, too. If you're not at AN18, submit bugs and feedback through the Feedback or Suggestions buttons; both buttons can be found at the bottom of the website. Learn more about the site's new features.
In theme of the week, we're throwing it back to a video from a previous SIAM Annual Meeting! Check out this short sizzle video to get a glimpse of what goes on at SIAM meetings and why folks are so excited to dive into this week. Watch the video.
Don't forget to subscribe to SIAM's YouTube channel so you see more of our content, more easily.
Did you know? There are 1,356 people pre-registered for #SIAMAN18 - or one of our corresponding meetings - #SIAMED18 and #SIAMMS18. There are so many amazing events in store for this week - check them out now in the most up-to-date online program schedule. Can't be in Portland with us? Stay up-to-speed by checking in on Facebook, Twitter, SIAM News, and following the #SIAMAN18 hashtag. We'll be posting all week!
Attending the SIAM Annual Meeting this week? Stop by registration and get your free TriMet transit pass, so you can get around Portland at no cost! Your TriMet transit pass – called a Hop Fastpass – allows you unlimited trips on MAX light rail trains, buses, and streetcars from July 8th to end of day July 13th. The pass covers all trips in the extensive TriMet network – the city of Portland, Portland International Airport (PDX), and surrounding suburbs. Looking for local restaurant recommendations? Check out this map.
Would you like to blog about conference talks and sessions happening at this week's Annual Meeting for SIAM News online? Email the editors at [email protected] with "AN18 reporting" in the subject line. Also be sure to check SIAM News for continual coverage of conference sessions. All articles about conference talks and sessions will be archived.
Submission deadlines for the SIAM Conference on Computational Science and Engineering (CSE19) are quickly approaching. Minisymposium Proposal submissions are due by July 25. Contributed Lecture, Minisymposia, Poster, and Minisyposteria Presentation Abstract submissions are due by August 22. Submit now.
Check out the SIAM conference calendar for a full list of SIAM meetings and those sponsored by SIAM, and review the Student Travel Award page to find out what conferences are offering awards.
July 9-11, 2018
SIAM Conference on Applied Mathematics Education (ED18)
July 9-13, 2018
2018 SIAM Annual Meeting (AN18)
July 9-13, 2018
SIAM Conference on Mathematical Aspects of Materials Science (MS18)
July 12-13, 2018
SIAM Workshop on Network Science (NS18)
August 6-9, 2018
SIAM Conference on the Life Sciences (LS18)
September 13-15, 2018
SIAM Conference on Mathematics of Planet Earth (MPE18)
The SIAM News Blog brings together updates on cutting edge research, events and happenings, as well as insights on broader issues of interest to the applied math and computational science community. Learn more or submit an article or idea.
Learn more


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Hi friends,
I am doing cnv calling using ERDS tool. ERDS provides a vcf file with cnv events. I would like to annotate the cnv events with gene level information. Therefore I am trying to use annovar to annotate the cnv events.
First step, I am converting the vcf from ERDS tool to annovar input format. So I used convert2annovar.pl program. I am getting the below error.
Did anybody face such an error with erds vcf conversion to annovar specific input?
$ perl annovar/convert2annovar.pl -format vcf4 sample1.erds.vcf > sample1.erds.avinput
Error: invalid record in VCF file: the GT specifier is not present in the FORMAT string: <chr1 10001="" .="" .="" <dup=""> . PASS IMPRECISE;SVTYPE=DUP;END=177000;SVLEN=167000 REFCN:CN 2:5>


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About Me
Meet the Founder: Laura
I've always had a creative side, and find enjoyment in the process of turning an idea into a reality. As a pediatric nurse, my work days are filled with high acuity situations and little down time. But they are also filled with a lot of joy, and children that inspire me with their mischievous grins, twinkling eyes, and make-believe worlds. They believe that anything is possible, so when my sister told me I was going to be an auntie, I decided it was the perfect time to take their lead and transform my latest idea into a reality. Petunia&Buster was born (and so was my sister's baby on September 8, 2016!)
Some people along the way have asked me where the name Petunia&Buster came from. Although I could say I picked it simply because it sounds ridiculously cute, there is also meaning behind it. When I was in nursing school I worked as a part-time nanny for a family that had two young kids, Ava and Jack. Their family possess the qualities and love for one another that I aspire to have for my own family one day. Ava and Jack, lovingly nicknamed Petunia and Buster, are two of the sweetest, well rounded and caring kids (along with their little sister, Ruby) that I am lucky enough to know.
I hope that you and your littles love the clothes as much as I do!
xo Laura
My beautiful baby niece, Eden
Photo courtesy of TLMacdonald


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Harrison County
Big Mike's Speakeasy making the big move in Gulfport
Big Mike's Speakeasy, a popular restaurant and bar near the waterfront, is moving to make way for the city's planned Mississippi Aquarium.
Big Mike's was on a month-to-month lease because it is one piece of the property the city assembled for the aquarium, slated to open in 2019. Big Mike's owner Amy Tennyson jumped at the chance for a smooth transition when the Irish Coast Pub gave up its lease in the first block of downtown's main street, 25th Avenue.
"We'll be right in the mix of things, so we're excited," Tennyson said. "Right now, we're in the process of cleaning, decorating and transferring licenses to open."
She hopes to make the move in mid-November. The current restaurant will close when the new one opens.
There's a lot to love about the current Big Mike's. It's in a rambling two-story building with a balcony that overlooks the harbor.
The new space is smaller, but has the feel of a speakeasy. Big Mike himself, aka Mike Brown, was sprucing up the new building Friday afternoon.
"He tries to say that he's the pretty face behind the name, but he just drives me crazy, basically," Tennyson said of her boyfriend.
Brown owned the restaurant's current building before the city bought it. When he lost the previous tenant, he talked to Tennyson, a real estate investor and former school teacher.
"He asked if I wanted to open a restaurant and I said, 'No,' and kind of fought it," she said.
She soon relented. Six years later, she's an experienced hand with a staff that feels like family.
The new building has a long dining room and a wooden oak bar in one corner. At the entrance, Tennyson has hung mementos from Prohibition days: A photo of men pouring a barrel of alcohol down a manhole and several prescriptions for alcohol issued under the National Prohibition Act.
Tennyson also plans to hang black and white photographs of Big Mike's regulars.
Big Mike's will be open daily from 11 a.m. until. Food will be served until 1 a.m. weekdays and until 2 a.m. on the weekends.
The menu will be smaller, but Big Mike's will continue to serve all the favorites: Daily lunch specials, hamburgers, the roast beef sandwich with real Chicago beef, macaroni and cheese and Pokey wings. General manager Pokey Bennett created the wing sauce, which is sweet with a spicy kick. The recipe is, of course, a secret.
For the first time, his wife, Beverly Bennett, will have a dish on the menu: Roast beef. Tennyson tried it the other day and it was so good she had to add it.
Big Mike's also will continue to serve mahi-mahi sandwiches and platters.
Ben Kaufman, who owned the Irish Coast Pub, will have his going-away party at the new Big Mike's. Kaufman closed his business for a director's job at Margaritaville Resort in Biloxi.


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Obreros: Jonathan Molina-Garcia
(b. 1989) Jonathan Molina-Garcia is a Salvadoran-American multimedia artist with a tenuous relationship to photography.
Indebted to a body of feminist, queer, decolonial, and poststructuralist scholarship, he remains a research-based artist, navigating process through texts and image archives. His work is interested in upending and intervening in how we define power, how it is represented, and importantly, how it is felt. He is an artist of mestizaje, pondering the ever-present hyphenation inherent in local (Molina-Garcia) and collective (Salvadoran-American) identity.
He holds an MFA degree in Photography from the California Institute of the Arts (CalArts), and graduated with a BFA in Photography and a BA in Art History from the University of North Texas. Recent exhibitions include "Cut-Ups: Queer Collage Practices" at the Leslie Lohman Museum of Gay and Lesbian Art in 2016, and its previous sister iteration, "Cock-Paper-Scissors" at the ONE Archives gallery in Los Angeles, California; both curated by the ONE Archives Foundation.
He is the recipient of the 2017 Mind the Gap microgrant from the Art Tooth organization and the 2014 Jack Kent Cooke Graduate Arts Award, and has been awarded various other project and developmental grants.
He currently lives and works in Dallas, Texas.
DRP: Hello Jonathan, tell me where you are from.
JMG: Hi Raul! I was born in Apopa, a city close to the capital of El Salvador. I immigrated when I was six, and grew up in Arlington, TX up until I started college.
DRP: How would you describe the kind of photographic work would you say you do?
JMG: My work is deeply photographic, but generally speaking I am a lot more interested in processes of image assembly. My projects have most often used collage and montage-based processes, methods involving cutting, stitching, gluing the photo object. My arrival to photography came by way of literally "taking" images (out of magazines and printed matter, and later out of almost exclusively digital domains, like tumblr and other image archives). Only later did I touch a camera. Casting what I do as "image assembly" is a way for me to denote something a lot grander that the photograph achieves, in the way it constructs meaning and the photographer's ability to compose, edit, and erase that significance.
So by way of interacting with photographic media by altering it, my trajectory as a photographer has involved teasing out the physicality of photographic technologies, and that desire perhaps accounts for the promiscuity of my practice - the way I've moved across different formats and devices.
DRP: The particular images we're sharing today work a lot like a documentary project. They follow a group of construction workers amidst their day labor; painting, roofing, and working seemingly in well established neighborhoods. Could you talk about this work?
JMG: Yes, it's interesting that we would bring up this project in the context of how I work as a photographer, and you're right to point out that it works "like" a documentary project, but maybe not completely. It's a small set of images, I switch between color and B&W film. The Odessa images include a fair amount of abstraction, but "portraits" in the more conventional sense of the word are far and few in between.
DRP: Did you know any of the workers prior to taking these images?
JMG: I knew quite a few of the roofers before I started. There were two I didn't know, and they don't appear in the project as it currently stands. That wasn't totally deliberate. One of them told me he didn't want to be included, and I was too shy to approach the other, whom I harbored a little bit of a crush on. I knew the others - Danny, Flaco, Bocho, and Choncho - from working with my brother, Elmer. Shortly after I dropped out of my first year of college in New York, I returned home - unemployed - and sought out Elmer's help. I worked with them for three months to save money before I started school in Denton. So the project picks up a few years after that first term of employment.
DRP: Were you surprised by anything while covering the laborers and their environment?
JMG: The interesting thing about this environment is that though it is populated by a Latino workforce, it is not, in fact, a body composed of undocumented Latinos. Perhaps this deserves emphasis, particularly now when the relentless racism and xenophobia in our political climate erases and flattens so much difference. Latinos are a patchwork, legally-speaking. We come with green cards, with full-on citizenship, with complicated statuses, and nothing at all.
This plays out in the construction industry all the time, where brown people of different citizenship status regularly work alongside each other.
So the frequently cited line that immigrants "take" jobs really reveals the fractures we have in our conception of latino labor - which is usually targeted as being the subject that is doing the taking - and of how we conceive of citizenship. Meaning, the conferment of citizenship has less to do with the immigrant's place of origin or foreignness, and more to do with the immigrant's color, assimilation, and language abilities.
As a real world example of this playing out in daily life, people are sometimes very surprised that I came to the United States illegally, a "coming-out" that says a lot about the class and social assimilation I've gone through as a DREAMER, and the sort of spaces I've been granted access to.
DRP: When you created these images, where you trying to convey or inform anything in particular?
JMG: The most impressionable experience of working construction is probably the vision and proximity it affords you. As a painter, you see the skeleton of a home, and you're on the ground. As a roofer, you have a bird's eye view, and the taller the home, the greater the perspective (and distance) becomes.
That's a really important spatial and body orientation because it reproduces a very familiar labor disparity that exists between the people who work indoors versus the people who work outside. The painters here would fall in the first category, and the roofers are in the second. I can say that it's a complicated experience - with a lot of ambiguity and loaded history - but certainly it is deeply felt. Down to the body - the way roofing as a profession wears heavy on the skin, sagging and browning from so much sun exposure.
So I suppose one of the most striking things about revisiting this work is considering how those two different physical positions carry into a visual language.
What happens in the photographs is that people frequently come in and out of concealment and often those shifts are also accompanied by a change in proximity to the camera. Danny, for example, is cloaked in shadows in the image above – the only one addressing the camera - and then appears out of them in the image below.
JMG: Iconographically, the Lencho Painting photograph is one of my favorites, for the way it most closely resembles all that i feel about the opacity of the brown body. That photograph is my way of asking questions about the stages of invisibility and visibility that we pass through. At what moments are we hidden and out of sight, and where/when are we revealed.
DRP: Does this series of works inform any work you are currently pursuing? Why or why not?
JMG: Completely, although there's a lot missing in the chronology of the Roofers and Painters project and what I'm doing now, and that leap is largely out of the different political consciousness that we now inhabit and the different work I've made since.
The roofers project for me always left off with a few open-ended questions; how does the queer identity of the photographer affect the development of a project about a mostly male Latino culture? Are my photographs queer? Are erotics present?
Without my pointed address, I feel this is a level of intersectionality that remains just under the surface, or too easily excluded from a broad survey of the photographs.
But my questions about the phenomenology of immigrant life is all-consuming now. And I can't stop thinking about the spotlight on DREAMERS, the way we seem to be getting shepherded into assuming this country's idealism about what and who the immigrant should be.
Right now I'm trying to build a mechanical camouflage suit that can be worn to aid border-crossers. The design involves sourcing images from Big Bend National Park, and printing photographic reproductions unto the suit that are altered through a motorized rotation. It's a heavy technical project. I've been given a tremendous helping hand in the form of a microgrant by the folks at Art Tooth, so look forward to seeing that soon!
The difference between the two projects is obvious (and possibly staggering), but the suit is just a way to hybridize some lines of thought about how I've been dealing with photographic technologies and the body.
DRP: We are definitely looking forward to the fruiting of your work Jonathan. Thank you for the talk. Good luck with the project!
View more of Jonathan Molina-Garcia's work on his website here.


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Anyone who grows up in Sandton spends a lot of time hanging out at pools and drug-filled parties – for this part of Johannesburg is the richest spot in the whole of Africa. Necktie Youth portrays this first post-apartheid gilded youth in striking black-and-white. Soft colours are reserved for their childhood memories of the early years of the rainbow nation. White 19-year-old Emily did not understand the codes of their set and could not take the pace of the ever-changing, fleeting liaisons, says the super cool, black and privileged September when he tries to explain to a TV reporter why Emily hung herself in her parents' garden. She even positioned her camera in such a way that her suicide could be streamed live.
In his film – in which he also plays a leading role – filmmaker and multimedia artist Sibs Shongwe-La Mer portrays a world in South Africa he knows like the back of his hand, a world where Mandela is now only a gold-framed icon. In today's Johannesburg this icon collides with reality: it is no longer a question of the conflict between black and white, instead confrontation plots a rapid zigzag course, moulding the dreams and excesses of young people of every colour.


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the kindergarten teacher
Director: Sara Colangelo Screenplay: Sara Colangelo Genre: Psychological thriller Co-production: MAVEN PICTURES / PIA PRESSURE Budget: $2.4m
Status: Shot Over Summer 2017. Sold Netflix North America, Protagonist selling rest of world.
Based upon the acclaimed Israeli Film, and directed by Sara Colangelo (whose film LITTLE ACCIDENTS was a multiple award winner), THE KINDERGARTEN TEACHER tells the story of a woman (Maggie Gyllenhaal), who sees such great promise in her five year old student.She goes to unreasonable and ultimately criminal lengths to protect his talent, sacrificing her career, family, and life. Gael Garcia Bernal plays Simon opposite Maggie.
Forty years old, stuck in Staten Island married to a sweet but oblivious husband and living with kids that don't pay her much mind, Lisa Spinelli goes through her days teaching Kindergarten with growing numbness. Her one reprieve - a night time poetry class across the bay in Lower Manhattan. When she discovers a five-year-old in her class may be a prodigious poet, Lisa becomes fascinated, then obsessed, as she pushes farther and farther to protect him from neglectful parents and a plagiarising babysitter, risking her career, family and freedom to nurture his artistic promise.
★★★★★ The Guardian


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|From 2009 Photo-A-Day
Planning our menu to get us through January.
The binder in the background is stuffed full of favorite recipes.
I was also making my grocery list with my iPod Touch! SO COOL!
Some yummy meals to come.
I will be sharing our menu with links to recipes on Monday over at The Beans Blog for Menu Plan Monday!


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Been a little busy lately with doing some photos for The Magnet Agency's amazing new blog. Check out their latest post about matte lippie. Tess Parker was amazing and the perfect goofball in front of the lens. These are digital images but the photo booth strips are real. I scanned the strips and put in the digital images and added the Magnet logo to give them the feel of an authentic photo booth photo strip. Gotta love the Photoshop machine.
Check out the blog post here (click the image):


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Local Bites: Grill Cooking Style at The Melting Pot St. Pete
It's been a little bit since I last enjoyed dinner at The Melting Pot - the closest one to our place is in Carrollwood, which I consider a little bit of a trek from our condo in South Tampa. But, what slipped my mind, was that there's a location in St. Pete, which means it's more convenient than ever to enjoy a 2+ hour experience in an effort to wind down from my work day (because I work in St. Pete).
What I didn't know (and eventually learned), is The Melting Pot has some menu offerings that are unique to each location - on a recent visit, my work wife (Ashley) and I got the opportunity to check out a new grill style cooking option that's offered at the St. Pete location. If you thought fondue was fun, grill style cooking is an even more elevated experience! Keep scrolling for the delicious eats:
For our cheese fondue choice, we opted for the classic Wisconsin Cheddar and chose to make it gluten-free by substituting Court Bouillon for the beer (Ashley is gluten-free by choice). I guess it'd been so long since I last went to The Melting Pot, that I didn't realize how incredibly gluten-free friendly the menu is!
The Wisconsin Cheddar fondue is just as delicious as I remember it being, and the Rosemary Fries definitely enhanced the course!
Confession: For our salads, we both ordered the Bacon & Bleu Spinach and I was so hasty with scarfing it down that I didn't take a photo - and I didn't even realize it.....until I started writing this post. I know. Face palm.
For the grill course, we both agreed that we needed some surf and turf in our lives, and ordered The Classic (Certified Angus Beef® Sirloin, Memphis-Style Dry Rub Pork, Herb-Crusted Chicken Breast, Teriyaki-Marinated Sirloin and Shrimp) and the Land & Sea (Premium Filet Mignon, Herb-Crusted Chicken Breast and Shrimp).
We had such an amazing time, and dinner was absolutely delicious! My personal favorite combinations were the herb-crusted chicken with curry dipping sauce and the shrimp with the green goddess dipping sauce. So, so good!
Finally, we ended our four-course experience with the Dark & Dulce chocolate fondue - this is the fondue to order. It paired wonderfully with pound cake, was dangerously decadent with brownies and the perfect sort of palate cleanser with strawberries and pineapple.
I definitely recommend trying the grill style cooking option the next time you head to The Melting Pot in St. Pete - and don't forget that the four-course experience is just that - an experience that typically lasts two hours (more if you're with fantastic company).
The Melting Pot St. Pete is located at 2221 4th Street North in St. Petersburg. The restaurant is open for dinner Monday through Thursday from 5 p.m. to 10:30 p.m., Friday from 5 p.m. to 11:30 p.m., Saturday from 4 p.m. to 11:30 p.m. and Sunday from 4 p.m. to 10:30 p.m. Brunch is also served on Sunday from 11 a.m. to 3 p.m. You can view all of the menus here. To stay updated on the latest happenings at The Melting Pot, follow along on Facebook, Twitter and Instagram.
*Disclosure: The meal featured in this post was provided by The Melting Pot for editorial consideration. This post was written on my own accord, and opinions expressed here are my own and are not indicative of the opinions or positions of The Melting Pot or Front Burner Brands.


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Call the fire department because I am scorching the sheets!
In all my rush to get ready for my epidural in four days, I forgot to get one of my prescriptions – an important one. The one that keeps the "mean, hot times "anyway".
At one point I was so hot and sweaty, I took my temperature – I just knew I was going to blow the end of the thermometer. It was 97.2.
It can't last forever, right?