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Using silk strands pulled from cocoons and gold wires thinner than a spider's web, researchers at Princeton University have created a removable tattoo that adheres to dental enamel and could eventually monitor a patient's health with unprecedented sensitivity.
In a laboratory in Princeton's Engineering Quadrangle, a graduate student demonstrated the system's wireless capability, breathing across a sensor attached to a cow's tooth. Instantaneously, the sensor generated a response to the student's breath and transmitted a signal to a nearby monitor.
"This is a real-time, wireless response from a sensor that can be directly interfaced with a variety of biomaterials," said Michael McAlpine, the team's principal investigator. He said the system not only has the ability to supply fast results, but is able to detect very small amounts of bacteria — a feature that could prove critical in treating certain diseases.
The researchers created the tattoo by bundling the silk and gold with graphene — an extremely thin sheet of carbon in which atoms are arranged in a honeycomb lattice. The material's unique properties allowed the researchers to construct a small, flexible device able to detect bacteria at a much higher sensitivity level than traditional methods. In tests, the researchers detected samples of bacteria that can cause surgical infections and others that can lead to stomach ulcers.
"In principle, the graphene can be tailored to detect a range of different things," said McAlpine, an assistant professor of mechanical and aerospace engineering at Princeton. "It can be configured to detect DNA or certain viruses. Here, we detect a single bacterium."
By combining the graphene array with a small antenna, the detection can be picked up by a remote reader device that is small enough to be held in a user's hand.
The results were reported March 27 in the journal Nature Communications. In addition to McAlpine, the paper's authors included graduate student Manu Mannoor, undergraduate Jefferson Clayton, Assistant Professor of Electrical Engineering Naveen Verma and associate research scholar Amartya Sengupta at Princeton; Hu Tao, David Kaplan and Fiorenzo Omenetto of Tufts University; and Rajesh Naik, of the Air Force Research Laboratory. Support for the research was provided by the American Asthma Foundation and the Air Force Office of Scientific Research.
To build the devices, McAlpine's team first imprinted tiny graphene sensors onto an extremely thin film of water-soluble silk. (The Tufts researchers pulled silk strands from cocoons, dissolved them in a solution and dried the mixture to create the silk base.)
Next, the researchers made an antenna by depositing a pattern of thin gold strands onto the silk film, and connected it to the graphene sensors. When completed, the device resembles a common removable tattoo. To attach the sensor, the researchers place it against a tooth, or a person's skin, and wash it with water. The silk base dissolves in the water, but the graphene sensor and the antenna remain securely fastened to the spot.
To allow the device to detect certain types of bacteria, the researchers attached peptides — fragments of proteins — to the graphene sensors. The peptides bind to bacterial cells and allow the researchers to detect a signal change from the graphene sensors.
McAlpine said one of the goals was to create a device that was small, flexible and passive, capable of providing detection from within the body or other remote location. So the researchers designed the device without a power supply. Instead, an external radio transmitter held nearby the device delivers a signal that causes the device to resonate and transmit back its information.
"The antenna coil is what transmits the signal," he said. "You don't need a battery."
Designing the antenna was one of the project's challenges. The gold coil needs to be big enough to transmit a readable signal, but small enough to fit within the sensor's compact footprint. The team was able to attach the current version of the system to a cow's tooth; reducing the size of the sensor in order to fit onto a human's tooth would require further work.
"Typically, the quality with which you can transmit depends on the size of the antenna," said Verma, an assistant professor of electrical engineering. The researchers had to deal with the small size of the antenna by choosing geometry for the coil that resulted in sufficient coupling between an external reading unit and the device — this was achieved through a series of concentric twists.
The current design allows for detection at a relatively short but practical distance, roughly a centimeter. Verma said if longer range was needed for other applications, modifications could be developed for the system.
The researchers said one of the key developments of the research was the use of graphene with a biocompatible base, in this case silk. Current biosensors tend to be relatively rigid and heavy, and they are often uncomfortable for patients. In large part, that is a result of sensors' base material, called a substrate.
"When you make biosensors the traditional way, silicon is the substrate," said Mannoor, a graduate student in mechanical and aerospace engineering and the paper's lead author. "When you think of interfacing that on the body, silicon is very brittle. Silk allows for a dissolvable platform."
In addition to its flexibility and biocompatibility, the solubility of silk meant that it could wash away with water or be dissolved by the body's enzymes.
The team plans to conduct further studies to better understand the adhesion between the tooth enamel and the graphene sensor with the goal of achieving a longer-lasting bond and enhancing the longevity of the system. One of the challenges for a dental system is protecting the sensor from inadvertent damage from things like brushing.
"Ideally, you want something that would be there for a while," McAlpine said. "We have a ways to go before we could master that."


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Bio-inspired MEMS Direction Finding Acoustic Sensor for Air and Underwater Applications - Video Portal
Bio-inspired MEMS Direction Finding Acoustic Sensor for Air and Underwater Applications
LT William Swan, US Navy
A micromechanical directional acoustic sensor has been developed based on the coupled eardrums of the Ormia Ochracea fly. Previous versions exploited the bending resonance of the sensor and have required two sensors in an array to resolve arrival bearing ambiguity. Design changes have been implemented to exploit an additional resonant mode of the coupled oscillator, allowing for direction finding from a single sensor. Successful testing of this single-sensor direction finding method was performed in an anechoic room using a lock in amplifier for data capture. Additionally, a new sensor has been designed and fabricated, along with an appropriate housing, in an attempt to explore the feasibility of using this MEMS sensor in an underwater environment. The design and construction of the housing and the new sensor are presented here, along with initial characterization testing of the sensor response in water are presented in this thesis.

subset: commoncrawl


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Internal Moves Tarrant County, TX
Internal Moves by Mid-Cities Movers
Our internal moving services are ideal if you need to move a large piece of furniture from one room to the next, up and down the stairs, or out to the garage. It's also a good choice if you need something heavy moved like a large, as our teams have the proper training and experience to handle this heavy lifting with ease. It's not a service that is limited to the indoors, either. We can move yard furniture or other items for you with ease!
Get a Price Quote Cost for Tarrant County, TX Internal Moves
Mid-Cities Movers internal moving services work well for:
Staging a home
Completing home renovations
Staging a big party or event
Moving a recently purchased large item such as a piano, gun safe, exercise equipment, etc.
Moving yard equipment, furniture, or décor out of shed storage
You can parlay this option with our Mid-Cities Movers delivery services to really take the stress out of your life, too. If you have purchased heavy items mentioned above like furniture, we can pick it up, deliver it to your home, and move it throughout the home to where it needs to go.
As always with any Mid-Cities Movers moving service, you'll receive professionally trained, background checked, and drug screened movers who have the necessary experience to handle the lifting of these large, bulky items. We're here to help you, and our moving teams want to deliver the best customer experience possible!
This service is also available for business, too! If you need your office furniture rearrange or moved out, we're happy to lend a hand.


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Industry Insights
Amazon Textract uses machine learning to automatically extract text and data, including from tables and forms, in virtually any document – with no machine learning experience required
The Globe and Mail, MET Office, PwC, Healthfirst, UiPath, Teradact, Ripcord, Kablamo, Vidado, BluePrism, and Alfresco among customers and partners using Amazon Textract
SEATTLE--(BUSINESS WIRE)--May 29, 2019-- Today, Amazon Web Services, Inc. (AWS), an Amazon.com company (NASDAQ: AMZN), announced the general availability of Amazon Textract, a fully managed service that uses machine learning to automatically extract text and data, including from tables and forms, in virtually any document without the need for manual review, custom code, or machine learning experience. Amazon Textract goes beyond simple optical character recognition (OCR) to identify the contents of fields in forms, information stored in tables, and the context in which the information is presented, such as a name or social security number from a tax form or the product SKU or quantity in a warehouse from an inventory report. The extracted text and data can be easily used to build smart searches on large archives of documents, or can be loaded into a database for use by applications, such as accounting, auditing, and compliance software. Amazon Textract's API supports multiple image formats like scans, PDFs, and photos, and customers can use it with database and analytics services like Amazon Elasticsearch Service, Amazon DynamoDB, and Amazon Athena and other machine learning services like Amazon Comprehend, Amazon Comprehend Medical, Amazon Translate, and Amazon SageMaker to derive deeper meaning from the extracted text and data. To get started with Amazon Textract, visit https://aws.amazon.com/textract.
Many companies extract text and data from files such as contracts, expense reports, mortgage guarantees, fund prospectuses, tax documents, hospital claims, and patient forms through manual data entry or simple OCR software. This is a time-consuming and often inaccurate process that produces an output requiring extensive post-processing before it can be put in a format that is usable by other applications. That's because existing OCR technologies are unable to recognize common layouts like forms and tables, and only generate a lengthy and often inaccurate text dump. What organizations want instead is the ability to accurately identify and extract text and data from forms and tables in documents of any format and from a variety of file types and templates. Amazon Textract analyzes virtually any type of document, automatically generating highly accurate text, form, and table data. Amazon Textract identifies text and data from tables and forms in documents – such as line items and totals from a photographed receipt, tax information from a W2, or values from a table in a scanned inventory report – and recognizes a range of document formats, including those specific to financial services, insurance, and healthcare, without requiring any customization or human intervention. Amazon Textract makes it easy for customers to accurately process millions of document pages in just a few hours, significantly lowering document processing costs, and allowing customers to focus on deriving business value from their text and data instead of wasting time and effort on post-processing. Results are delivered via an API that can be easily accessed and used without requiring any machine learning experience.
"The power of Amazon Textract is that it accurately extracts text and structured data from virtually any document with no machine learning experience required. Subsequently, developers can analyze and query the extracted text and data using our database and analytics services like Amazon Elasticsearch Service, Amazon DynamoDB, and Amazon Athena and integrate with other machine learning services like Amazon Comprehend, Amazon Comprehend Medical, Amazon Translate, and Amazon SageMaker to help customers derive deeper meaning from the extracted text and data," said Swami Sivasubramanian, Vice President, Amazon Machine Learning. "In addition to the integration with other AWS services, the rich partner community developing around Amazon Textract makes it possible for customers to gain real meaning from their file collections, operate more efficiently, improve security compliance, automate data entry, and facilitate faster business decisions."
Amazon Textract takes scanned files stored in an Amazon S3 bucket, reads them, and returns data in the form of JSON text annotated with the page number, section, form labels, and data types. This data can then be used for a range of applications (e.g. generating smart search indexes, redacting text in a massive collection of forms, creating automated loan approval workflows, using the data for regulatory compliance, and flagging fraud risk for insurance claims). Customers can load the data into business software, such as spreadsheets, databases, and payroll systems, or they can analyze and query the data using Amazon ElasticSearch, Amazon DynamoDB, Amazon Redshift, or Amazon Athena. Amazon Textract is available today in US East (Ohio), US East (N. Virginia), US West (Oregon), EU (Ireland), and will expand to additional regions in the coming year.
The Globe and Mail is a national icon and Canada's most recognized media brand. "As a news media company, we rely on many PDF or scanned-source documents such as FOIs (freedom of information requests) that have important information contained in tables that we previously couldn't access," said Michael O'Neill, Managing Director of Digital and Data Science at The Globe and Mail. "These documents have been under-utilized because journalists were not able to access them easily or didn't know they existed. Using Amazon Textract, we are able to extract information from tables in PDFs and easily output that data to CSV and offer easy access to these documents by making them available for search queries by our journalists. This increases efficient access to information for our journalist by tenfold."
Met Office is the UK's national weather service, and is a world leader in providing weather and climate services. "We hope to use AmazonTextract to digitize millions of historical weather observations from document archives," said Philip Brohan, Climate Scientist at Met Office. "Making these observations available to science will improve our understanding of climate variability and change."
PwC helps organizations and individuals create value by delivering quality in assurance, tax, and advisory services. "At PwC, we work to provide our customers with intelligent automation tools that help transform previously manual processes. We've integrated Amazon Textract into our solution for the pharmaceutical industry to automate document processing for various FDA forms like MedWatch and CIOMS," said Siddhartha Bhattacharya of PwC. "Previously, people would manually review, edit, and process these forms, each one taking hours. Amazon Textract has proven to be the most efficient and accurate OCR solution available for these forms, extracting all of the relevant information for review and processing, and reducing time spent from hours to down to minutes."
Healthfirst is a not-for-profit managed care organization and one of the fastest growing health plans in New York with over 1.4M diverse members and a network of more than 35,000 providers and 4,500 employees. "At Healthfirst, we are building data pipelines to turn scanned medical charts into useful clinical information to improve care coordination, drive quality outcomes, and ensure appropriate reimbursement for members under our coverage," said Steve Prewitt, Chief Analytics Officer at Healthfirst. "We use Amazon Textract and Amazon Comprehend Medical to glean real value from unstructured data sources in an efficient way, resulting in revenue savings 10-20 times more than our usual downstream operation. By scaling up to analyze over 50,000 charts, we can find undocumented diagnoses and refer around 5,000 members for the care management they need."
Informed, Inc. automates how financial institutions originate loans and open bank accounts. "We have already used Amazon Textract to analyze tens of thousands of loan documents on behalf of financial institutions, and our own software-as-a-service offering has been enhanced by the service, enabling us to identify 95% of the defects in loan application packages and help banks reduce their manual data entry," said Justin Wickett, Founder and CEO, Informed Inc. "Using Amazon Textract, our software gives financial institutions real-time visibility into an applicant's income based off of their pay stubs, bank statements, tax returns, and other financial documents. We plan to expand the types of documents we analyze using Amazon Textract in order to enable financial institutions to take advantage of our machine learning models and bring real-time decision-making efficiency to today's slow and manual process."
Candor's mission is to transform the archaic, time consuming process that burdens the mortgage industry. "We use OCR to extract data from a wide variety of lender-required documents to verify income, assets, property value, and more. Until now, the best OCR solution read one page at the rate of 38.4 seconds, but Amazon Textract achieves this in a fraction of that time," said Tom Showalter, Founder & CEO of Candor. "We've been able to use Textract to accurately read complex, diverse documents such as bank statements, pay stubs, and tax documents without additional training or machine learning expertise, allowing our clients to underwrite and close a loan in days, as opposed to weeks."
UiPath is a leading Robotic Process Automation vendor providing a complete software platform to help organizations efficiently automate business processes. "Amazon Textract will further differentiate UiPath's robotic process automation platform by enhancing UiPath's document understanding capabilities, enabling our customers to unlock critical business data from documents, transform that data into actionable business insights, and deliver those insights into line-of-business and operational systems," said Param Kahlon, Chief Product Officer of UiPath.
TeraDact allows customers to transform stored images and paper documents into privacy-compliant, usable digital formats at scale. "Amazon Textract's smart docs platform feeds TeraDact's patented redaction services to automatically remove and secure sensitive data. TeraDact customers can permanently remove this data so that it can never be recovered or opt to replace sensitive data with patented tokens which can be recovered by individuals with the appropriate permissions. This is particularly useful in complying with government mandates surrounding individual data privacy such as GDPR," said Tom Trobridge, COO, TeraDact.
Ripcord's mission is to digitize and extract knowledge from paper documents using vision-guided robotics, machine learning, and advanced AI. This knowledge automates business processes and workflows. "We've had tremendous success utilizing Amazon Textract to augment our advanced entity extraction to benefit many industries and uncover $4 billion in new pay. We look forward to expanding our use of Amazon Textract across financial and government services, healthcare and legal," said Alex Fielding, CEO of Ripcord.
Blue Prism develops Robotic Process Automation software to provide businesses and organizations with a more agile virtual workforce. "Blue Prism's connected-RPA can automate and perform mission-critical processes, allowing customers the freedom to focus on more creative, meaningful work. By using Amazon Textract, we've given our digital workforce another powerful tool for automation. Amazon Textract accurately analyzes data from various document types using machine learning, which enhances the digital transformation journey for our customers. Using additional AWS AI services like Amazon Comprehend and Amazon Rekognition, we can tackle challenges from added secure customer authentication processes to fraud detection capabilities. The intelligence and flexibility of Amazon Textract's form data extraction can elevate OCR to new levels in industries like financial services, retail, manufacturing and transportation to name a few," said Dave Moss, CTO and Co-Founder of Blue Prism.
About Amazon Web Services For 13 years, Amazon Web Services has been the world's most comprehensive and broadly adopted cloud platform. AWS offers over 165 fully featured services for compute, storage, databases, networking, analytics, robotics, machine learning and artificial intelligence (AI), Internet of Things (IoT), mobile, security, hybrid, virtual and augmented reality (VR and AR), media, and application development, deployment, and management from 66 Availability Zones (AZs) within 21 geographic regions, spanning the U.S., Australia, Brazil, Canada, China, France, Germany, Hong Kong Special Administrative Region, India, Ireland, Japan, Korea, Singapore, Sweden, and the UK. Millions of customers including the fastest-growing startups, largest enterprises, and leading government agencies—trust AWS to power their infrastructure, become more agile, and lower costs. To learn more about AWS, visit aws.amazon.com.
About Amazon Amazon is guided by four principles: customer obsession rather than competitor focus, passion for invention, commitment to operational excellence, and long-term thinking. Customer reviews, 1-Click shopping, personalized recommendations, Prime, Fulfillment by Amazon, AWS, Kindle Direct Publishing, Kindle, Fire tablets, Fire TV, Amazon Echo, and Alexa are some of the products and services pioneered by Amazon. For more information, visit amazon.com/about and follow @AmazonNews.
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Sitting at long winter evenings near the open chimney, who doesn't dream about it? Something usual but rather inefficient at our grandmother's days is a luxury today. The "Home Flame collection" offers flame romanticism on a bio-ethanol base for every demand.
The combustion chamber with its ceramic sponge inside of it guarantees an especially beautiful, even flame game and simple availability until the last drop. The through thought construction allows an independent and free placing.
Design: Michael Rösing
More details:
Burning chamber information:
- low fuel consumption (approx. 500 ml per hour)
- low flames creation, also with low fuel level
- long burning time (1.7 litres capacity)
- low heat generation of the combustion chamber
- optimal safety through double-walled combustion chamber
- ignition also with low fuel level
- removable regulation flaps
- unlimited time of usage of the special-ceramic-burner
Corpus: steel panel, powder coated, black, heat resistant glass, stainless steel reflector 18/10 slightly brushed.
Combustion chamber: double walled high quality stainless steel 18/10 slightly brushed with step-less burning regulation.
Fuel: liquid bio-ethanol 96%, denatured with 1% mek. Essentially burns to become steam and carbon dioxide. It is not necessary to use thickening products like gel and pastes. Therefore a clean fire without traces is possible.


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Is Your Website Generating New Business
It wasn't that long ago that most websites were simply electronic brochures. They listed the who, what and where of the business but times have certainly changed.
Back then, converting your corporate brochure into an online brochure was a logical progression. The internet and search engine optimization were in their infancy and the most important thing was to have a web presence. Unfortunately, these types of websites no longer cut the mustard and with the evolution of the internet we have also seen a change in consumer behaviour. People now buy goods and services online including cars, holidays and whitegoods and to capitalise on this behavioural shift you need to upgrade your website from an 'electronic brochure' to a lead generation website.
Your prospective customers now turn to Google, your website and social media for answers. They start their buying journey browsing websites and gathering information, looking for educational content to help them make an informed buying decision. If your website content includes e-books, whitepapers, videos, infographics, cheat sheets, checklists, research or presentations you're on the right track. By educating your prospects you're effectively building trust in your brand and also positioning your website as a valuable resource centre. In the process you're moving your prospects closer to a sale.
If your website is still an electronic brochure full of bullet points that list your products and services here's an important message - the next generation of customers and clients expect more. They don't care about when you started the business, your promise of great service or your convenient location. They only care about whether you understand their pain and how you can solve their problem. Ideally, they want proof that you've helped people with similar issues and your solution is simpler and more effective than your competitors. The features, benefits and finer details of your business, your services and your products are really just 'fillers'.
Today's consumers are impatient. You only have a few seconds to prove that your business has the answers, the solution or the fix they are looking for. You want the standout website in your industry and it needs to send a clear message, be easy to navigate and provide calls to action so you guide the prospect to the next stage of the buying process. Have a look at your home page right now, does it tell your prospects what to do next? Call for a free consultation? Click here to download our free guide? Fill in the box for a free sample?
Content is king and you need to understand what your prospects are searching for in your industry. Tailor your content to their search terms, provide relevant information in your blogs, videos and FAQs. Identify the questions that your prospects are asking during the research stage and then create pages on your website that answer those questions. It's strategic and you'll probably find you include the important keywords in the process. Make sure you embed calls to action on those pages as well so should they be 'sold' on your information or answers they are only a click away from your cash register. Google craves fresh, original content so you need to keep adding content to your site. The truth is, your website is never 'done' and it will always be a work in progress.
Click HERE to download the full edition of The Business Accelerator Magazine for March 2017.
Other articles in this edition:
- Do You Really Need A Website?
- Get To Know Your Profit Margins
- Business Start Up Corner - How To Get Off To A Flying Start
- Buying Or Selling A Business? Make Sure It's A "Going Concern"
- Business Builders - Targeting Your Ideal Customer
- 7 Ways To Increase Your Email Marketing Success Rate
- Quick Tips For Social Media


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We live in a time of unprecedented information. The size of the digital universe is doubling every two years and yet it can sometimes feel harder than ever to access reliable facts on the internet.
This is particularly true of our industry. It can be easy to laugh off the latest questionable fitness fads, superfood sensations and tacky trends, but when it comes to exercise, bad advice for gymgoers can quickly shift from hilarious to dangerous.
In an age of self-proclaimed fitness gurus, influencers and experts – where anyone with a smartphone and a Twitter profile can shape opinion – the role of science in separating fact from fiction has never been more important.
As a result, Les Mills partners with universities around the world to conduct research which delves deeper into exercise science and tests the effects of Les Mills programs on key community health factors such as obesity and heart disease. The research is independent, peer-reviewed and industry-recognised.
Under the microscope
To date, there have been 13 articles published in peer-reviewed academic journals investigating the efficacy and impact of various approaches to fitness. These studies have ranged from the effects of high-intensity training on heart disease, hormonal and physiological responses to BODYPUMP, behaviour change, and how to get kids motivated to exercise.
As well as bringing new insight into the physiological impact of different training types, these academic partnerships help to refine the development of Les Mills programs and ensure they're underpinned by science.
Les Mills Head of Research, Bryce Hastings, explains: "When we're creating a workout, for example, our HIIT offering GRIT, we design it to take the heart-rate above 85 per cent as much as possible across 30-minutes – so you have very high spikes of intensity, followed by periods complete recovery. It's those spikes that generate the types of biochemical responses that are very specific to a HIIT workout.
"Once we think we've got it right, we send that workout to Penn State University in the US, and they'll rigorously test it to see if we're delivering on that HIIT promise and providing a workout that is guaranteed to deliver results."
Les Mills invests millions of dollars into research each year to maintain these scientific standards across its programs. These insights are harnessed by a team of experts to devise effective choreography for Les Mills programs, which are then screened through thousands of hours of in-club trialling before being released to the wider market.
Safety first
"From a program creation perspective, there's an exhaustive range of measures we take to ensure workouts are safe and consistent," adds Les Mills Chief Creative Officer Dr Jackie Mills MD, who for many years combined her role at Les Mills with a career as a medical practitioner.
"The Program Directors work in teams much more now, so there are lots of people working in unison to constantly test, iterate and revise the programs before they go to Penn State. They then have to go through the rigours of Bryce and the Creative Directors – after that, I review them. Nothing is left to chance!"
Investing in ongoing research is a vital part of Les Mills' business. In this era of misinformation and unreliable sources, it enables health club partners and their members to be confident that their group fitness programs are effective and safe.
Research projects Les Mills has led recently include our studies on RPM and arterial health, CXWORX and running, group dynamics, and even a study about push-ups and the impact of doing them on your knees versus on your toes. This year, further research will explore in greater detail stress and training loads, as well as BODYPUMP and anti-ageing.
"We want to keep on evolving our workouts in ways that meet the expectations of our club partners and their members on all levels – from exercise technique and safety to instructor experience, workout intensity and much more," adds Hastings.
"Rather than simply focusing on physiological research, our approach could be described as 'all-encompassing'. For example, we know that motivational and behavioural aspects of fitness like the group effect have a significant impact on a person's long-term commitment to exercise, so the breadth of research is important."
And for Les Mills club partners, be sure to access Brand Central for a wealth of marketing social media resources you can share with your current and future members to keep them updated on the science behind their results.
View our research
To stay up to date with the latest research findings keep visiting the Les Mills website and to learn more about our past work check out


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Eminem - There He Is Şarkı Sözleri
There He Is
(Bobby Creekwater)
[Intro: Bobby Creekwater]
Yesssss, ladies and gentlemen (yeah man)
Bobby Creekwater, today's host
Today's narrator, yeah
(We do this shit every year around this time)
Today's what-the-fuck-ever you wanna call it
But I need y'all to sit back, and listen
Listen man (fuck what you write man, just go get 'em)
[Verse One]
An executive mindframe, fuck tryin to rap
Niggaz represent a corner, I refined the map
Artesian water, this is flow untapped
And rep for 'em like Mike on playoff night; that's if the payoff right
The dream team, Bobby Creek, Em, 50 and them
We +Run the City+ like Diddy and them
The opposition we just pityin them, it's no chance
Put you niggaz in the special olympics is no dance
I'm nice like a meal twice, nigga no grams
Get them bitches out they pants, I did it with no hands!
See, one thing's for sure I'm pure uncut
Baby you can either stay down or get gunned up
Mr. Night Life, I can give you niggaz sun up
I just get an order, let my niggaz pick the gun up
That's when I bone ya, nigga wake yo' punk ass up
This is ammonia, fuck your face up
Bitches won't even telephone ya
I can space age pimpin, a pocket full of stone ya
Ya dig? Take the world over that's the gig
Sell enough units have Paul and Jimmy dancin the jig
Roll the Maserati through the city, me and Riggs
Bumpin Obie Trice, shoot a bird at the pigs
Ever since a nigga got rich
Life is still a bitch but she a high class bitch
I just wanna fuck with me a high class bitch
Nigga pitch that on some eyeglass shit
See I classic, enough to get the mics back right
And I'm a fan of record sales, I don't like that hype
I'm here to end it
Oh Lord that nigga mean, ain't he?
Yea, goddamn that nigga clean, ain't he?
Yea, see he a greedy baby
But some people tend to call him the return of Shady
There he is - goddamn that nigga clean, ain't he?
Yea, oh Lord that nigga mean, ain't he?
Yea, see he a greedy baby
But some people tend to call him the return of Shady
Bobby Creek, Bobby Creek...
[Verse Two]
Yea, yeah
Nice like Mike right, you niggaz soft as night lights
Diamond's a tall order I'm just tryin to get the hype right
I'm throwed off, so hard, so soft, sold out
Bought the Coupe a color of nice weather and rolled out
I can't hold out, hot like a fish fried
Who the fuck is this guy? The ruler on the disc I
Hit you in your suit coolers, I'm in the Coupe cooler
than pigskin men base runners and hoop shooters
A loose screw ban money like the legendary Roots crew
This is just the shit that I am used to
Oh nah, I don't bust a chopper but I used to
Now I put the word out - I'm sure you niggaz heard 'bout
Young boss sold money, old school new paint
Ball knowin you can't, give a fuck what you think
Member of the mighty Shady Records, nigga you ain't
Think you fuckin with me then double whatever you drink
You can't fathom what the bitch throwin at him
Couple niggaz hatin on him but the fans waitin on him
like a, PlayStation 3, money for your advance
My vacation fee, ain't no use in hatin me nigga
And don't shit-talk pimp, I'd rather flush
anyone with big enough nuts to come and fuck with us
I bust but keep in mind, pressure bust pipes
And you niggaz wouldn't bust a grape in a fruit fight
What the fuck? (yeah)
Bu şarkı sözü
kere okundu.
Şarkı Sözleri


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The CMS Chronic Conditions Data Warehouse (CCW) provides researchers with Medicare and Medicaid beneficiary, claims, and assessment data linked by beneficiary across the continuum of care. In the past, researchers analyzing data files were required to perform extensive analysis related to beneficiary matching, deduplication, and merging of the files in preparation for their study analysis. With the CCW data, this preliminary linkage work is already accomplished and delivered as part of the data files sent to researchers.
The Chronic Conditions Data Warehouse (CCW) is a research database designed to make Medicare, Medicaid, Assessments, and Part D Prescription Drug Event data more readily available to support research designed to improve the quality of care and reduce costs and utilization.
Further reading –


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Key features
Serato Pitch 'n Time DJ controls
A series of dedicated buttons were created to trigger the key-related functions in Serato DJ Pro. Switch between the Key Shift, Key Sync and Key Reset to play with keys without ever changing your tempo.
Multi-coloured Performance Pads
Use the large, multi-coloured tactile Performance Pads to trigger the Hot Cues, Roll and Sampler features. Hit the pads and watch their colours change as they indicate the selected pad mode and playing status.
Portable design
Take this controller with you wherever you go thanks to the easy grab handles and lightweight design. For simple plug-and-play connectivity you can choose between USB or AC power.
Multiple connections
Balanced XLR outputs let you connect to a professional PA system, while a booth and 2 master outs allow you to monitor your mixes. Or use the DDJ-SR2 as a mixer with multiplayers or turntables using the line and phono inputs.
Large jog wheels
It may be compact, but this controller features large, low-latency jog wheels to give you great scratch response and accuracy.
Integral control of Serato DJ Pro
Get involved with plug-and-play control of Serato DJ Pro with dedicated buttons for FX and advanced features such as Hot cue, Slip mode, Roll and slicer. Simply connect your PC/Mac and start playing.
Audio mixer feature
Use the DDJ-SR2 to control the channel faders and trims of external equipment such as turntables and media players. Additionally, you can also manipulate sound from external sources using the software's EQs and FX when the controller is connected to a PC/Mac running Serato DJ Pro.
Dual Level Meter
See the master out and channel levels at all times.
Needle search
Needle search provides a touch strip for intuitive and fast searches. Jump to any part of a track with one touch.
DVS upgrade-ready
The DDJ-SR2 is Serato DJ DVS ready. The Serato DJ DVS Expansion Pack allows you to scratch with CDJs or analogue turntables using Serato NoiseMap Control CD/vinyl.


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Powerful Form Builder
Easy-to-use donation form builder to create fast fundraising campaigns and easily customize it for your audience.
An efficient, optimized donation form that integrates with your nonprofit website within minutes!
No special coding skills or expertise required. Integrating Donorbox into your Wix website is a simple process!
Your fundraising success is our priority. With easy integration with your Wix site, Donorbox comes packed with promising features to increase your donations.
Easy-to-use donation form builder to create fast fundraising campaigns and easily customize it for your audience.
Our donation forms are PCI compliant and secured by SSL/TLS. We do not store any bank data! Plus, fraud detection against scammers testing stolen cards.
Easily collect and export donor data. Filter and sort your donors. Record donor information and interactions. Communicate effectively and build great donor relations!
A robust donation system with responsive design that can be easily optimized for mobile and other devices.
A goal meter next to your donation form lets you share your fundraising progress and achieve your fundraising goal fast.
Honor your donors by enabling a donor wall. Recognizing contributors helps build lasting relationships.
If you are using Wix to build your website, you can still add a popup donation form on your website. Wix website editor is widely popular and simple to create functional websites. In a few simple steps, you can add a donation form to your Wix website and start fundraising ...
Donorbox fundraising software easily embeds on your Wix website and the process is really simple! There is no special coding required and the process will take you only a few minutes. Donorbox's simple, responsive, and smart donation...
Wix is one of the most popular website builders around. Wix is a drag-and-drop platform that seems to constantly be improving. And it's designed for people with little to no knowledge about creating a website. Anyone with a computer and an internet connection can...
Software para Organizaciones sin Fines de Lucro
Mejor Desempeño
Software de Gestión de Donaciones
Mejor Desempeño
Software de Fundraising
Mejor Desempeño
Mejor rankeado en Capterra
4.8/5 (123)


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Cupid Fireplace Back Plate
Excl. VAT. For sales to individual customers in the EU, VAT is charged. For individual customers outside the EU, 0% VAT applies, but they may have to pay VAT in their own country (e.g. UK, Switzerland, Canada). Shipping quotes include handling and 100% insurance but exclude possible local duties and tax.
In Stock
Condition | *** Classification: ***: Very good condition, limited wear given the age and use. **: Clear signs of wear and possible structural problems including small instabilities. Still well suited for use in an open fireplace. *: Structural instability that hinders function other than decorative. For example, open fireplace tongs with a loose mechanism so that the ends can overlap. A fireback in this classification can still be used in a gas fireplace or as a backsplash. Should you want additional information about the quality or the classification of a specific fireplace accessory, do not hesitate to ask. |
Age | 19/20th century |
Style | Victorian |
Origin | France |
Width | 29.5 cm | 11.6 inches |
Height | 60.0 cm | 23.6 inches |
Depth | 1.5 cm | 0.6 inches |
Weight | 17 kg | 37 lbs |
Materials | Cast iron |
Color | Brown If an old or antique fireplace accessory has a nice brown patina of rust, we tend to preserve that; thus the items remains brown. In all other instances, our firebacks and andirons have been treated with stove polish and thereby have a black/greyish color. If you prefer to have a black-colored fireback or pair of andirons, we can deliver any brown fireback or pair of andirons in black. Yet, a black fireplace accessory cannot be delivered in brown. Realize that a fireback in use in a fireplace will get black in its central section regardless. |
Reference | n6302 |


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(AP)—Russian hackers attacked at least one U.S. voting software supplier days before last year's presidential election, according to a government intelligence report leaked Monday that suggests election-related hacking penetrated further into U.S. voting systems than previously known.
The classified National Security Agency report, which was published online by The Intercept, does not say whether the hacking had any effect on election results. But it says Russian military intelligence attacked a U.S. voting software company and sent spear-phishing emails to more than 100 local election officials at the end of October or beginning of November.
U.S. intelligence agencies declined to comment.
Capitol Fax: Illinois elections software vendor hacked by Russians
However, the Justice Department announced Monday it had charged a government contractor in Georgia with leaking a classified report containing "Top Secret level" information to an online news organization. The report the contractor allegedly leaked is dated May 5, the same date as the document The Intercept posted online.
The document said Russian military intelligence "executed cyber espionage operations against a named U.S. company in August 2016 evidently to obtain information on elections-related software and hardware solutions, according to information that became available in April 2017."
The hackers are believed to have then used data from that operation to create a new email account to launch a spear-phishing campaign targeting U.S. local government organizations, the document said. "Lastly, the actors send test emails to two non-existent accounts ostensibly associated with absentee balloting, presumably with the purpose of creating those accounts to mimic legitimate services."
The document did not name any state.
The information in the leaked document seems to go further than the U.S. intelligence agencies' January assessment of the hacking that occurred.
"Russian intelligence obtained and maintained access to elements of multiple U.S. state or local electoral boards," the assessment said. The Department of Homeland Security "assesses that the types of systems Russian actors targeted or compromised were not involved in vote tallying."
The Intercept contacted NSA and the national intelligence director's office about the document and both agencies asked that it not be published. U.S. intelligence officials then asked The Intercept to redact certain sections. The Intercept said some material was withheld at U.S. intelligence agencies' request because it wasn't "clearly in the public interest."
The Associated Press could not confirm the authenticity of the May 5 NSA document, which The Intercept said it obtained anonymously.
Also on Monday, Reality Leigh Winner, 25, of Augusta, Georgia, was charged in U.S. District Court with copying classified documents and mailing them to a reporter with an unnamed news organization. Prosecutors did not say which federal agency Winner worked for, but FBI agent Justin Garrick said in an affidavit filed with the court that she had previously served in the Air Force and held a top-secret security clearance.
Winner's attorney, Titus Thomas Nichols, declined to confirm whether she is accused of leaking the NSA report received by The Intercept. He also declined to name the federal agency for which Winner worked.
"My client has no (criminal) history, so it's not as if she has a pattern of having done anything like this before," Nichols said in a phone interview Monday. "She is a very good person. All this craziness has happened all of a sudden."
In affidavits filed with the court, Garrick of the FBI said the government was notified of the leaked report by the news outlet that received it. He said the agency that housed the report determined only six employees had made physical copies. Winner was one of them. Garrick said investigators found Winner had exchanged email with the news outlet using her work computer.
Garrick's affidavit said he interviewed Winner at her home Saturday and she "admitted intentionally identifying and printing the classified intelligence reporting at issue" and mailing it to the news outlet.
Asked if Winner had confessed, Nichols said, "If there is a confession, the government has not shown it to me."


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Hong Kong Smart Design Award 2024
ALL RIGHTS RESERVED. Powered by SourceLab
Disclaimer: The Government of the Hong Kong Special Administrative Region provides funding support to the project only, and does not otherwise take part in the project. Any opinions, findings, conclusions or recommendations expressed in these materials/events (or by members of the project team) are those of the project organisers only and do not reflect the views of the Government of the Hong Kong Special Administrative Region, the Culture, Sports and Tourism Bureau, Create Hong Kong, the CreateSmart Initiative Secretariat or the CreateSmart Initiative Vetting Committee.


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The Baluchistan bear is a subspecies of the Asiatic black bear. It is also called "moon bear" because of a distinctive white crescent marking appearing on the chest. It is similar in appearance to its better-known American relative (the American black bear). The head tapers to a rather pointed snout, and it has rounded ears which are large and prominent. Adults reach between six and eight feet in head and body length on average, and weigh between 110 to 330 lbs. The tail is 2.5 to 4 inches long. Males are larger than females. Baluchistan bears have very sharp claws and are excellent climbers and swimmers.
This species prefers forest habitat which includes temperate and tropical woodlands in hilly or mountainous areas with heavy brush cover. It spends much of the day sleeping and is mainly active at night. Diet consists of fruits, nuts, buds and insects. Asiatic black bears are more carnivorous than their American counterparts since they are known to eat leftover prey killed by tigers, which helps to build up fat before winter. They have also been known to consume domestic livestock. Except mothers and cubs, they are usually solitary. Mating may occur around October, and females give birth to two cubs after a gestation period of seven to eight months. The young are nursed for three to four months and remain with the mother for two years.
The Baluchistan bear is only found in Iran and Pakistan and is threatened by habitat destruction and hunting for its skin, paws and gall bladder (which is used in Oriental medicine). They are considered a nuisance to humans since they eat crops and domestic livestock, and unfortunately, human attacks are also common. All Asiatic black bears are protected by law, but law enforcement is extremely limited in much of its range.
Wikipedia Article Copyright Notice: This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Asian black bear". |
Featured ArticleOrphaned cougar cubs progressing well at Toledo Zoo
Back in October, the Toledo zoo received new additions to their creature family... two orphaned cougar cubs, rescued from Washington state when they were 3 weeks old.
Read More... |


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You may shake your head with painful memories of large dollar amounts lost, and swear on a stack of Bibles that you will never again be foolish enough to engage in a shoot-out with the One-Armed Bandit, but who are you kidding? Maybe, with a little luck, you will be able to resist the call of the slot machine for a few weeks, perhaps even a month or two. But you know damn well that you'll be back for a rematch sooner or later. You can't just let that Bandit win so easily, can you? No way.
It's just a machine, after all, with a "brain" comprised of wires and microchips. You, on the other hand, are a living, breathing entity with the capacity for critical thinking and self-reflection. If humankind is to have any hope at all in surviving the global war against machines that surely will come some day, we'd better at least be able to beat the slots. Think of the matter in this kind of sweeping historical context and you will see that it's not simply a choice but an obligation for you to get back on the horse as soon as possible.
Before launching on your noble quest in defense of humanity, it would be wise to review some basic information and arm yourself with five crucial tips to success.
You may not know that the slot machine goes by different names in overseas nations. For instance, within the United Kingdom, it is called a fruit machine (no jokes about British drag queens, please.) In Australia, the slot is known as a "poker machine," which is even more confusing, but what can you expect from a culture that gives outdoor grills the name of a little girl's toy? (Let it sink in for a minute, you'll get it.)
Anyway, traditional American slot machines jackpot slot online are coin-operated and contain three or more reels, which spin when a lever on the side of the machine is pulled. The machines include a currency detector that validates the money inserted to play. The machine typically pays off based on patterns of symbols visible when the reels stop.
OK, enough for the description. Now, onto those tips that were promised a few paragraphs ago:
Tip #1
Become intimately acquainted with each slot machine's payout schedule. Two identical slot machines will often have radically different payouts. This matters, people.
Tip #2
Look for advertised slot machines offering 96-98% paybacks. Most casinos usually have a few banks or carousels of high percentage payback slots, and this is where you should play.
Tip #3
Join the casino players club wherever you gamble regularly. Casinos reward players for time and money spent. Even if you don't hit the jackpot, you may still receive comps like meals, discount hotel rooms, and other perks.
Tip #4
This should be a no-brainer, but only play the slot machines you can afford and only spend money you can risk losing. Seriously.
Tip #5
Walk away when you're losing and become irritated. Playing slot machines is supposed to be an enjoyable pastime, not a source of ulcer-inducing frustration. When it's no longer fun, go get a drink and some fresh air.


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a scheme that will only reward its subscribers. An emerging concept of fast-rewards for fast food . . .
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Why subscribe?
Loyalty Magazine is the only title reporting exclusively on the global loyalty business. It carries reports, research, analysis, guest articles and comment on customer retention, loyalty programmes, reward programmes, affinity, customer insight, new technology, CRM and other customer information management systems, customer engagement, digital loyalty, social media interaction and mobile. (Phew!)
We will keep you informed of the progress of digital transformation, artificial intelligence (AI) and voice adoption, the use of blockchain and the emergence of marketplaces - for both B2B and B2C enterprises.
Loyalty Magazine covers all global markets and business sectors, including retail, financial services, travel and hotels, telecoms, entertainment, experiences, gamification and technology.
- PLUS it provides with full information about The International Loyalty Awards (formerly theLoyalty Magazine Awards) plus profiles of the Finalists and the Winners. As The International Loyalty Awards are the most prestigious award event for those working in customer loyalty, this is a very interesting resource indeed!
- In addition you can browse and search through many years of valuable content.
- An email will be sent regularly with details of items, so you will never miss important content.
So hurry up and subscribe! We can't wait to welcome you to a very special loyalty community.


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We just celebrated our one year anniversary. We've lived all over the globe to create seven unique issues that each portray a different city and the culture around its skateboard scene.
We want to thank everyone that supported us during these incredible journeys – this clip is for you!
Filmed and edited by Matt Phipps
Additional filming by Steven Ban, Chris Theissen, Ryan Lovell, Atsushi Sugimoto, Doug Gerhardt


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changes.mady.by.user Armin Kathrein
Saved on Mar 19, 2020
Saved on Mar 23, 2020
This Work Group operates under the Kantara IPR Option: Patent & Copyright: Reciprocal Royalty Free with Opt-Out to Reasonable And Non discriminatory (RAND)
Join | Subscribe | Archive (Mailman) | Archive (Google) | Charter | Participant Roster 2016 | Minutes | Kantara Initiative Bylaws (Mail archives prior to Oct 6, 2009)
Title: Consent Receipt Specification (download here)
Version: 1.1.0
Date: 2018-02-20
Editors: Mark Lizar, David Turner
Status: This document is a Kantara Initiative Technical Specification Recommendation produced by the Consent & Information Sharing Work Group, and has been approved by the Group. The Public Comment and Intellectual Property Rights Review has been completed. It has been approved by the Membership of the Kantara Initiative. See the Kantara Initiative Operating Procedures for more information.
Abstract: A Consent Receipt is record of authority granted by a Personally Identifiable Information (PII) Principal to a PII Controller for processing of the Principal's PII. The record of consent is human-readable and can be represented as standard JSON. This specification defines the requirements for the creation of a consent record and the provision of a human-readable receipt. The standard includes requirements for links to existing privacy notices & policies as well as a description of what information has been or will be collected, the purposes for that collection as well as relevant information about how that information will be used or disclosed. This specification is based on current privacy and data protection principles as set out in various data protection laws, regulations and international standards.
Many Consent Receipt Implementations - list of implementations of Consent Receipts or derivatives
Questions and answers about the specification from implementers are here.
In September 2019 FDX announced a collaboration with Kantara and a supporting Kantara Consent Receipt Infographic -v02.pdf.
The receipt specification enhancement project is active as of December 2018.
For now, we are managing the list of proposed enhancements as Github issues.
Github Project: https://github.com/KantaraInitiative/consent-receipt-v-next/projects/2
Github Issues list: https://github.com/KantaraInitiative/consent-receipt-v-next/issues
Liaisons with CISWG/Consent Receipt update from Liaisons Officer Mark Lizar, as presented to the Kantara European Plenary May 2019
Kantara presented the demo at EIC 2019 and is scheduled to present improved versions at Identiverse 2019 and MyData 2019.
A webinar recording of the slides on YouTube
The slides on SlideShare: kantara-privacy-control-panel-demonstration-2019-0515
NEW: Demo video for ISSE 2019 Brussels
The project to assemble v2 of the demo is active as of December 2018. Throughout 2019 the WG team will be refining and growing the demo functionality.
The draft demo description being discussed in the WG is:
The main purposes of the Kantara Initiative Privacy Control Panel (Kantara PCP) system are a) to allow people to see, organize, find details via a 'data processing receipt' construct about the conditions under which they agreed to provide information for data processing; and b) to give them tools to investigate the data processing receipts they might have received or modify the permissions they granted when they initially shared the data for processing.
In the Kantara vision, whenever an individual is asked for their personal data, or whenever their personal data is acquired, a 'data processing receipt' is created by the data controller. The receipt includes details about the conditions under which the data was obtained: the privacy notices provided; the lawful basis and purposes for collecting and processing data; the terms of the agreement and other metadata related to the interaction.
These data processing receipts could be offered by the data controller's system to the individual for storage in their personal Privacy Control Panel application.
Once the data processing receipts are in the personal PCP, the person can organize them and inspect them to ensure they are valid, current and actually represent what happened.
The PCP gives the person tools to take action with the receipts including view, validity check, request the data, revoke consent, change permissions, or erase the data. In other words to exercise their data subject rights.
On the consent management platform and data controller system side, standard data processing receipt APIs could be offered. The PCP utilizes these APIs.
Kantara presented a demonstration of Interoperable Consent Receipts at the MyData 2018 conference, Helsinki, August 28, 2018 in the Consent In Action Session there are excellent presentation videos - it's a very interesting conference.
Five Kantara Members who are active Consent & Information Sharing Work Group contributors invested developer time to create external Kantara-spec Consent Receipts. These receipts were stored at a user-specified location, then viewed using a viewer created by OpenConsent. From start to finish, it took about 7 weeks to design, build, test and deliver.
The Consent Receipt presentation was recorded and is posted (YouTube).
And the slides can be downloaded (pptx).
The demo was a hit - lots of conference delegates engaged with the presenters and we are hoping to see that interest result in more WG participants and more demo apps - and hopefully some of these in shipping products!
The demo was then presented at the Kuppinger Cole CIAM World Tour USA, Seattle, September 21, 2018 with similar interest and engagement.
Next stop: Amsterdam for the Kuppinger Cole CIAM World Tour Europe, October 29-31, 2018
After the first two conference presentations, we now have two more solutions to fit into the demo.
This working group has been evolving since 2009, starting out as the Information Sharing WG focused on catalysing a rich flow of consent based personal information - from a CRM perspective - actual demand data (as opposed to predicted demand) can be engineered with better personal data control then could be found in any traditional CRM products and departments. The first work stream was led by Joe Andrieu and Iain Henderson, which produced the Information Sharing Label Notice for people.
In 2012, Open Notice Initiative, (now the Kantara Liaison Partner Open Consent Group), presented a paper Opening up the Online Notice Infrastructure An 'Open Notice' Call For Collaboration, at the W3C Do Not Track & Beyond Conference.
The result of this effort was the proposal to Kantara, ISWG to focus on a consent work stream, which resulted in this WG name change to the Consent & Information Sharing WG (CISWG). This work stream has focused on making an identity management usable consent record called the "Consent Receipt", driven largely by major contributions from Mary Hodder, John Wunderlich, Iain Henderson and Mark Lizar who brought the spec to a v.1, with a special thanks to David Turner and extra special effort of Andrew Hughes to bring together the release of V1.1 to be published on May 25, 2018 . This specification is now growing adoption in the EU and US healthcare, consent management, policy frameworks, smart contracts.
Special mention to UMAWG and Eve Maler for providing the shining example for how to develop a specification by consensus and Justin Richer for building the first consent receipt generator
This Workgroup is open for interested participants, the work product that is produced is under a Royalty Free (openly usable) RAND license. The work produced is provided for review by industry, public sector, regulators, other standards organisations like the ISO of ISO/IEC JTC 1/SC 27/WG 5, and community partners; like Project VRM, who have supported the long term development of tools for individual autonomy over personal information.
Project VRM community also drive a work stream in CISWG with Customer Commons called User Submitted Terms, which is focused on a common set of icons that customers can use to signal their intent.
The WG members often meet at conferences and workshops in the US and EU, which happen annually for those who want to meet in person.
Active Projects:
Publications & Submissions
All WG Projects:
This blog post on the Personal Data Eco-system is useful background and context for this working group.
Download the Consent Receipt Overview
CALENDAR: https://kantarainitiative.org/calendars
Call times:
Consent Receipt: Thursdays - 15:30 GMT, 07:30 Pacific, 10:30 Eastern Time
User Submitted Terms: Wednesdays - 16:00 GMT; 08:00 Pacific; 11:00 Eastern
GoToMeeting (GTM1)Please join the meeting from your computer, tablet or smartphone.
https://global.gotomeeting.com/join/323930725 You can also dial in using your phone. United States: +1 (669) 224-3318 Access Code: 323-930-725
GoToMeeting (GTM1)Please join my meeting from your computer, tablet or smartphone.
Please join my meeting from your computer, tablet or smartphone. https://global.gotomeeting.com/join/323930725 You can also dial in using your phone. United States: +1 (669) 224-3318 Access Code: 323-930-725 More phone numbers Australia: +61 2 9091 7603 Austria: +43 1 2530 22500 Belgium: +32 28 93 7002 Canada: +1 (647) 497-9376 Denmark: +45 32 72 03 69 Finland: +358 923 17 0556 France: +33 170 950 590 Germany: +49 692 5736 7300 Ireland: +353 15 360 756 Italy: +39 0 230 57 81 80 Netherlands: +31 207 941 375 New Zealand: +64 9 282 9510 Norway: +47 21 93 37 37 Spain: +34 932 75 1230 Sweden: +46 853 527 818 Switzerland: +41 225 4599 60 United Kingdom: +44 330 221 0097


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Biologists uncover regulatory mechanism for gene expression in the visual system
- Date:
- June 10, 2011
- Source:
- New York University
- Summary:
- Biologists have uncovered a key regulatory mechanism used for gene expression in the visual system. Their findings offer new insights into the complexity behind the genetic make-up of biological systems.
- Share:
Biologists have uncovered a key regulatory mechanism used for gene expression in the visual system. Their findings, which appear in the latest issue of the journal Cell, offer new insights into the complexity behind the genetic make-up of biological systems.
The study, which included researchers from New York University's Department of Biology, Japan's Okayama University, Cincinnati Children's Hospital, and Germany's University of Würzburg, examined the photoreceptor cells in the retina of the fruit fly Drosophila. Drosophila is a powerful model for studying eye development as it is amenable to very specific genetic manipulations, allowing researchers to analyze how its visual system functions when its different elements are affected.
Though scientists have identified specific roles for many genes in various biological contexts, the ways in which these genes interact are poorly understood. This is especially the case with the eye, an extraordinarily complex system. For example, in the Drosophila eye, expression patterns of Rhodopsins -- the light detectors of the retina -- determine at least 13 distinct types of photoreceptors.
Among their goals, the researchers sought to address how genes interact in distinct ways in different cells. In other words, how do genes work in networks to control the exquisite and precise patterns of rhodopsin gene expression?
In the Cell study, the researchers identified a gene that is a critical node in this network -- one that regulates the expression of several rhodopsin genes in the visual system. They specifically looked at how this network figured in Rhodopsin expression in several types of photoreceptors that are normally used for motion detection or color vision.
In their comparison between normal and mutant visual systems, the researchers found that the transcription factor gene defective proventriculus (dve) is a critical node in the network regulating Rhodopsin expression. In dve mutants, the Rhodopsins normally found in the color vision photoreceptors are expressed in the motion detecting photoreceptors. This mutation causes defects in light detection especially when flies are presented with subtle differences in light levels.
The dve gene is a shared component of two opposing, interlocked feed-forward loops (FFLs), which serve as critical network motifs controlling gene expression. Specifically, in one FFL, Dve acts to repress Rhodopsin expression in the motion detecting photoreceptors. Moreover, in the color vision photoreceptors, a second FFL relieves repression by Dve while activating Rhodopsin expression. Therefore, this network serves to both restrict and induce cell type-specific expression. This interlocked FFL motif may be a general mechanism to control gene expression, the researchers concluded.
"We know that genes work in combinations, but the coherence of interactions across cell types is not well understood," said Robert Johnston, a post-doctoral fellow in the laboratory of NYU biologist Claude Desplan, two of the study's co-authors. "We show how these networks function across several different cell types -- this mechanism makes sure that Rhodopsins are in the right cells."
The research was supported by a grant from the National Eye Institute, part of the National Institutes of Health.
Story Source:
Materials provided by New York University. Note: Content may be edited for style and length.
Journal Reference:
- Robert J. Johnston, Yoshiaki Otake, Pranidhi Sood, Nina Vogt, Rudy Behnia, Daniel Vasiliauskas, Elizabeth McDonald, Baotong Xie, Sebastian Koenig, Reinhard Wolf et al. Interlocked Feedforward Loops Control Cell-Type-Specific Rhodopsin Expression in the Drosophila Eye. Cell, Volume 145, Issue 6, 956-968, 10 June 2011 DOI: 10.1016/j.cell.2011.05.003
Cite This Page:


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Why did you decide to do this project? 2 years ago I decided to close my facebook account and send and receive letters instead and the idea of my REAL wall was born. REAL posts on a REAL wall. It didn't take long before I started to receive mailart and discovered a whole artform and community of talented and positive individuals, who inspired me to find my inner artist. Mailart365 is a homage to the worlds mailartists and to that community of people who keep the postal system not just alive but positively vibrant. It is my way of saying thanks to the people who strive to send a smile through the post.
How has doing a yearlong/daily project affected your life? The excitement of the participants building up to the launch date of December 1st, 2010 has been incredible and initial signs are that everyone is really thrilled to be involved. It's been such a buzz and the whole challenge has really galvanised many people into creating. The creative spirit that everyone has shown has made the project seem like it's going to be a breeze, but I suspect that it won't be. Already, I've found that I've been really busy keeping the site looking good and making sure that all participants are happy, but I think that this will die down and I will soon get back to the creation of artworks, which I can't wait for. If it's had an effect on my life, so far I can say it's given me a huge feeling of pride to have created and seen through the idea and to collaborate with so many people I admire.
I have personally started thinking in terms of collage and picking up every scrap of paper I see "because it might come in useful somewhere" and both me and my fiance have now got a legitimate excuse to spend Saturday mornings on eBay buying rubber stamps again!
Follow the progress of all of the participating mail artists on their site HERE.


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We are committed to safeguarding the privacy of our website visitors; this policy sets out how we will treat your personal information.
What information do we collect?
We may collect, store and use the following kinds of personal data:
- Information about your computer and about your visits to and use of this website (including your IP address, geographical location, browser type, referral source, length of visit and number of page views)
- Information relating to any transactions carried out between you and us on or in relation to this website, including information relating to any purchases you make of our goods or services.
- Information that you provide to us for the purpose of registering with us (including title, forename, surname, postal address, postcode, email address, telephone numbers including mobile phones and employment status)
- Information that you provide to us for the purpose of subscribing to our website services, email notifications and/or newsletters (including title, forename, surname, postal address, postcode, email address, telephone numbers including mobile phones and employment status). If you wish to access or amend the data that we hold, please contact email@example.com.
- Any other information that you choose to send to us.
- Other information.
A cookie consists of information sent by a web server to a web browser, and stored by the browser. The information is then sent back to the server each time the browser requests a page from the server. This enables the web server to identify and track the web browser. We may use both "session" cookies and "persistent" cookies on the website. We will use the session cookies to: keep track of you whilst you navigate the website. We will use the persistent cookies to: enable our website to recognise you when you visit. Session cookies will be deleted from your computer when you close your browser. Persistent cookies will remain stored on your computer until deleted, or until they reach a specified expiry date. We use Google Analytics to analyse the use of this website. Google Analytics generates statistical and other information about our website use by means of cookies, which are stored on users' computers. The information generated relating to our website is used to create reports about the use of the website. Google Analytics will store this information. A copy of Google's Privacy Policy can be view at: www.google.com/privacy. Most browsers allow you to refuse to accept cookies. (For example, in Internet Explorer you can refuse all cookies by clicking "Tools", "Internet Options", "Privacy", and selecting "Block all cookies" using the sliding selector.) This will, however, have a negative impact upon the usability of many websites including this one.
Using your personal data
Personal data submitted on this website will be used for the purposes specified in this privacy policy or in relevant parts of the website.
- We may use your personal information to:
- Administer the website;
- Improve your browsing experience by personalising the website;
- Enable your use of the services available on the website;
- Send you general (non-marketing) commercial communications;
- Send you email notifications which you have specifically requested;
- Send to you our newsletter and other marketing communications relating to any of our businesses or the businesses of carefully-selected third parties which we think may be of interest to you by post or, where you have specifically agreed to this, by email or similar technology (you can inform us at any time if you no longer require marketing communications)
- Provide third parties with statistical information about our users – but this information will not be used to identify any individual user;
- Deal with enquiries and complaints made by or about you relating to the website.
- Other uses.
- Where you submit personal information for publication on our website, we will publish and otherwise use that information in accordance with the license you grant to us.
- We will not without your express consent provide your personal information to any third parties for the purpose of direct marketing.
We may disclose information about you to any of our employees, officers, agents, suppliers or subcontractors insofar as reasonably necessary for the purposes as set out in this privacy policy.
In addition, we may disclose information about you:- To the extent that we are required to do so by law;
- In connection with any legal proceedings or prospective legal proceedings;
- In order to establish, exercise or defend our legal rights (including providing information to others for the purposes of fraud prevention and reducing credit risk); and
- To the purchaser (or prospective purchaser) of any business or asset which we are (or are contemplating) selling.
- Except as provided in this privacy policy, we will not provide your information to third parties.
Security of your personal data
We will take reasonable technical and organisational precautions to prevent the loss, misuse or alteration of your personal information. We will store all the personal information you provide on our secure (password- and firewall- protected) servers. All electronic transactions you make to or receive from us will be encrypted using SSL technology.
Of course, data transmission over the internet is inherently insecure, and we cannot guarantee the security of data sent over the internet.
You are responsible for keeping your password and user details confidential. We will not ask you for your password. -
Google AdWords and Remarketing
Think Creative uses all features of Google Analytics for Display Advertisers. That includes obtaining specific visitor cookie data, such as the source, medium and keyword used to visit our website. Google Analytics does not store any visitor specific data and we will not use visitor specific data in any way related to Google Analytics, Google AdWords and Remarketing.
Think Creative uses remarketing with Google AdWords and Google Analytics to display content specific advertisements to visitors that have previously visited our site when those visitors go to other websites that have the Google Display Network implemented.
Think Creative and other third-party vendors, including Google use first-party cookies (such as the Google Analytics cookie) and third-party cookies (such as the DoubleClick cookie) together to inform, optimize, and serve ads based on visitor's past visits to our website.
When creating remarketing lists, we can't use any sensitive information about users. This includes information such as their financial status, sexual orientation, and other sensitive categories.
As AdWords advertisers, we are restricted from and will not perform the following actions: (a) Running ads that collect Personally Identifiable Information (PII) including, but not limited to, email addresses, telephone numbers and credit card numbers (b) Creating a remarketing list or creating ad text that specifically targets users in ways that are outlined as "prohibited".
Visitors can opt out of Google Analytics for Display Advertisers and opt out of customised Google Display Network ads by visiting the Ads Preferences Manager.
Definitions : "User" means a unique instance of a browser, application or similar technology. "User Cookie" means the User identifier (of which a cookie is one example) associated with a User for remarketing or similar audiences. "Remarketing Lists" means a list of User Cookies created or otherwise obtained by you and used in connection with remarketing or similar audiences. "Similar Audiences Lists" means a list of Users created by Google based on a Remarketing List for use in connection with similar audiences. "Properties" means properties or content on which advertisements are shown.
Policy amendments
We may update this privacy policy from time-to-time by posting a new version on our website. You should check this page occasionally to ensure you are happy with any changes.
We may also notify you of changes to our privacy policy by email. -
Your rights
You may instruct us to provide you with any personal information we hold about you. Provision of such information may be subject to the payment of a fee (currently fixed at £10.00).
You may instruct us not to process your personal data for marketing purposes by email at any time. (In practice, you will usually either expressly agree in advance to our use of your personal data for marketing purposes, or we will provide you with an opportunity to opt-out of the use of your personal data for marketing purposes.) -
Third party websites
The website contains links to other websites. We are not responsible for the privacy policies or practices of third party websites.
Updating information
Please let us know if the personal information which we hold about you needs to be corrected or updated.
If you have any questions about this privacy policy or our treatment of your personal data, please contact us or by write to: Index House, Midhurst Road, Liphook, Hampshire GU30 7TN


text:
Dance on Bikes! |
Bikes are not being used only for practice or urban move, but also as a tool for expression. See below some bike-dancing teams: |
Ποδηλατοβόλτες, Εκδηλώσεις |
Ποδηλατοβόλτες, Εκδηλώσεις |
"What do you call a cyclist who doesn't wear a helmet? An organ donor."
"All creatures who have ever walked have wished that they might fly. With highwheelers a flesh and blood man can hitch wings to his feet."
"Think of bicycles as rideable art that can just about save the world."
"Things look different from the seat of a bike carrying a sleeping bag with a cold beer tucked inside."
"The secret to mountain biking is pretty simple. The slower you go the more likely it is you'll crash."
"You never have the wind with you - either it is against you or you're having a good day."
"The sound of a car door opening in front of you is similar to the sound of a gun being cocked."
"Cycle tracks will abound in Utopia."
"If we all, mountain bikers, cyclists, multinational companies, Jo Public, respected the land like old civilizations we wouldn't get so many punctures. Earth's revenge."
"Messengers and mountain bikers share a common chromosome."
"The hardest part of raising a child is teaching them to ride bicycles. A shaky child on a bicycle for the first time needs both support and freedom. The realization that this is what the child will always need can hit hard."
"Cycling is unique. No other sport lets you go like that - where there's only the bike left to hold you up. If you ran as hard, you'd fall over. Your legs wouldn't support you."
"Until mountain biking came along, the bike scene was ruled by a small elite cadre of people who seemed allergic to enthusiasm."
"Melancholy is incompatible with bicycling."
"The bicycle is just as good company as most husbands and, when it gets old and shabby, a woman can dispose of it and get a new one without shocking the entire community."
"The bicycle will accomplish more for women's sensible dress than all the reform movements that have ever been waged."
"A bicycle does get you there and more... And there is always the thin edge of danger to keep you alert and comfortably apprehensive. And getting there is all the fun."
"For instance, the bicycle is the most efficient machine ever created: Converting calories into gas, a bicycle gets the equivalent of three thousand miles per gallon."
"The bicycle is the most civilized conveyance known to man. Other forms of transport grow daily more nightmarish. Only the bicycle remains pure in heart."
"Why should anyone steal a watch when he could steal a bicycle?"
"Tens of thousands who could never afford to own, feed and stable a horse, had by this bright invention enjoyed the swiftness of motion which is perhaps the most fascinating feature of material life."
"It would not be at all strange if history came to the conclusion that the perfection of the bicycle was the greatest incident of the nineteenth century"
"The bicycle is a curious vehicle. Its passenger is its engine."
"The bicycle, the bicycle surely, should always be the vehicle of novelists and poets."
"The three largest bike sharing schemes in Europe are used for trips equivalent to going around the world ten times each day"
"Life is like riding a bicycle - in order to keep your balance, you must keep moving."
"When I see an adult on a bicycle, I do not despair for the future of the human race"
"Poetry is the development of a shining bicycle... This is a never ending trip."
"There are two types of mayors: those who have bikesharing and those who want bikesharing."
"Nothing compares to the simple pleasure of riding a bike."


text:
Jason J. Kane is a Partner who practices out of the firm's New York office. He focuses his practice on representing investors in Financial Industry Regulatory Authority (FINRA) arbitrations and in federal and state lawsuits.
Jason graduated from the State University of New York at Geneseo, in 2004, with a B.A. in Economics. He attended the Syracuse University College of Law, and received his Juris Doctorate, cum laude, in 2007.
While attending the Syracuse University College of Law, Jason served as a form and accuracy editor for the Syracuse Journal of International Law and Commerce. He also gained valuable experience as a law clerk for Magistrate Judge George H. Lowe and was an intern at the United States Attorney's Office in the Northern District of New York.
Following law school, Jason began his career working in the Legal Department of Wegmans Food Markets, Inc., one of Upstate New York's largest employers. At Wegmans, Jason worked with the finance, real estate and human resources departments, as well as outside counsel.
Since 2009, Jason has focused his practice on representing investors. Jason has represented hundreds of investors in Upstate New York and around the country. He has recovered millions of dollars in FINRA arbitrations while representing individuals against their former brokers and brokerage firms. He often assists his victimized clients through the regulatory and criminal investigations that result from large-scale scams perpetrated by their brokers.
A member of the Public Investors Arbitrators Bar Association (PIABA), New York State Bar Association, and Monroe County Bar Association, Jason takes great pride in his ability to lead his clients through the process of restoring their financial losses suffered as a result of their financial advisor's bad advice.
New York
Western District of New York
[email protected]
Pittsford, NY
Syracuse University College of Law
State University of New York
Bachelor of Arts


text:
Dialog Windows
Dialogs can be modal, in which case the user is required to provide necessary information before work in the main window can continue, or modeless. Modeless dialogs do not prevent the user from interacting with any of the other windows in the application.
Qt provides a set of ready-made dialogs for file, font, color-selection and more.
Dialog widget for specifying colors | |
Dialog that allows users to select files or directories | |
Dialog widget for selecting a font | |
Simple convenience dialog to get a single value from the user | |
Modal dialog for informing the user or for asking the user a question and receiving an answer | |
Feedback on the progress of a slow operation |
Custom dialogs can be easily created by composing regular widgets into a QDialog. These classes are specifically designed for building custom dialogs:
The base class of dialog windows | |
Widget that presents buttons in a layout that is appropriate to the current widget style |
© 2024 The Qt Company Ltd. Documentation contributions included herein are the copyrights of their respective owners. The documentation provided herein is licensed under the terms of the GNU Free Documentation License version 1.3 as published by the Free Software Foundation. Qt and respective logos are trademarks of The Qt Company Ltd. in Finland and/or other countries worldwide. All other trademarks are property of their respective owners.


text:
NOTIFIER continuously develops new technologies that improve life safety in buildings worldwide. Our solutions will help you determine the best system to meet the needs of your application.
Basket Size : 0 MB out of 50 MB
All files above 20 MB can only be downloaded by clicking on the file. They cannot be added to the basket/e-mailed as zip file


text:
Rosemary Leach
Category: Library
Ric Leach
Elizabeth McKellar
Rosemary Leach
Ric Leach
Elizabeth McKellar
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text:
Joshua Ledet Has Another Stellar Night! "Ain't Too Proud to Beg" and "To Love Somebody" [VIDEOS]
Tonight we were in Joshua's hometown of Westlake, Louisiana. It's a beautiful thing! Everyone is so excited for Joshua, it's contagious actually. People came from all over to cheer Joshua on. Joshua is in American Idol's elite Top 5 and there's no slowing him down.


text:
Topics Map > Research Policy and Compliance > Human Research Protection Program (HRPP) > HRPP Policies
IRB Members' Conflicts of Interest
The policy you are looking for has migrated to the UW–Madison-Policy Library at policy.wisc.edu. The policy library brings all university-wide policies together in one place so you can quickly locate the most accurate, up-to-date version of a policy.
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