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The Galveston Historic Seaport has compiled the nation's only computerized listing of immigrants to Galveston, Texas. The museum's immigration exhibit features text and historic photographs illustrating Galveston's role in immigration history and the major organized immigration movements of the 19th and 20th Centuries. Computer terminals in the exhibit area allow visitors to search for information taken from ships' passenger manifests pertaining to their ancestors' arrival in Texas. For your convenience, the database is also available online.
In addition, the Galveston County District Clerk provides a web-based portal for immigration records. That can be accessed here.
What information is provided? The database includes names of passengers and members of their traveling parties, age, gender, occupation, country of origin, ship name, dates of departure and arrival, and destination in the United States. Information is also provided for a small number of ship arrivals. The ship database includes ship name, type of ship, master, home port of ship, arrival date at Galveston, port of departure, destination port, tonnage, number of immigrants, shipowner, and citation source.
Searches of the Galveston Immigration Database are based on surnames – the family's last name. The first data retrieved is a table of all the last names that match the last name of the search. If an exact match is not found, a table of names closest to the spelling of the search name will appear on the screen.
The passenger arrival records normally listed people traveling together as a single record and included several first names. When these records were entered into the database, space limitations allowed a maximum of 7 names to be recorded as a single "family unit". If there were more than 7 people in the traveling family unit, the information was split into two records. This explains why, if you find several people with the same last name, it is possible that when you view the record for that family, you will see the same family details page.
The majority of the people who came to Galveston were either single men or wives with children. There were many complete families, but more often they came at different times. Usually, one of the male family members immigrated first, to make enough money to afford to send for the rest of the family.
How was this information gathered? The museum staff transferred records from microfilm of Department of Justice Immigration and Naturalization Service passenger manifests from the National Archives, books containing additional source material and isolated passenger lists published in The Galveston Daily News. Additional sources continue to be researched for future inclusion in the database.
In all, the names of more than 130,000 passengers from the period 1846-1948 have been entered. The database lists only those who first disembarked in Texas. Many immigrants came through New York or one of the other East Coast ports and trans-shipped to Texas. Family legend may hand down a Texas port of entry, while immigration records reflect an Eastern port.
Are the records complete? An unknown percentage of the records are missing; there are very few entries between 1871 and 1894.
I know my family immigrated through Galveston, but I can't find them in the database. Why?
An individual may not appear for many reasons:
- There are gaps in the data. Galveston immigration data is not available from the National Archives between the years 1871 and 1894; further, some records are missing near the time of the 1900 hurricane.
- Some records were unreadable. As the Galveston Historic Seaport staff entered listings in the database, some microfilm records were to faint to read. These records, handwritten by sea captains, may not be complete or 100% accurate.
- Names may have changed. Changes in the spelling of surnames sometimes occurred as records were entered, or over the generations. When searching, try different spellings of the same name, or similar sounding versions of your family name [for instance, the German "Schmitt" may have been Anglicized to "Smith" – or may appear as "Schmid" or "Smit".]
- Your ancestors may have stopped elsewhere first. This database only reflects the names of immigrants whose first disembarkation was in Texas. If your ancestor's ship called in New York before coming here, its records would not appear in the Galveston Historic Seaport listing.
But I have proof that my ancestor immigrated through Galveston. Is it possible to correct the omission in this database?
Yes, with some limitations. From time to time, the Galveston Historic Seaport hopes to budget for staff to update these records.
If you would like to provide documentation of an arrival through Galveston, Indianola, Beaumont, or other Texas port, please contact the museum office at 409-763-1877. While the museum's ability to schedule these updates is uncertain at this time, xerox copies of documents [passenger manifests, immigration papers, stamped passports] are welcome. The Galveston Historic Seaport is not responsible for original documents left in its possession.
I found my ancestor, but the information in the Galveston Immigration Database doesn't agree with family legend.
Congratulations on your successful search! The listings in the Galveston Immigration Database are transcriptions of records provided by the captains of ships calling in Texas. Although no guarantees of accuracy are made, the listing may supply information that corrects or fills in stories passed from one generation to another. Another possibility: you may have found an immigrant not related to your family, but who shares the same name.
I want to know more about my family. Where do I go?
Your local library is the best place to get started. Ask for help finding the local genealogical society. Some libraries also have files and other genealogical resources on hand to help you begin your search.
But isn't this a genealogy research facility?
The Purpose of the Galveston Historic Seaport Galveston Immigration Database is to make existing records easily accessible. This project reflects listings of immigrants already available to the public elsewhere through the National Archives and several published sources. As a demonstration of the way Galveston contributed to the growth of Texas and the midwest, it shows at the touch of a keyboard many of the important themes at the Galveston Historic Seaport.
We encourage genealogy enthusiasts to use the database as a "jumping off" point, but caution that this is only one of a number of sources of information.
I have family photos from my Galveston immigrant ancestors. Would the museum be interested?
Certainly. The Galveston Historic Seaport hopes to add to the collection of family pictures displayed near the database terminals on the museum's second floor. Please send copies only to: Galveston Historic Seaport, Pier 21 & Harborside Drive, Galveston, TX 77550. If your pictures are selected for use, you will be notified, and arrangements will be made for copies to be made of your originals at the museum's expense.


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Touring the Magnificent Ukraine
Ukraine is a unique country known for its vast history and mystery. It is home to the city of Kiev, the oldest city in Europe. The Dnieper River which flows from the north to the south and into the Black Sea cuts the country in half.
From the airport
There are plenty of airports in Ukraine, but most of the international flights land at the Boryspil international airport. Whichever airport you land in, you are going to need some transport to the city. The main transport options include taxis, buses or car. You can rent a car and tour the country in style and at your own pace. Cheap car hire companies are available in plenty, hence car rental is an issue that should not stress you exceedingly. Additionally, most car rental companies have online services and you can hire one online before landing in the country.
Boryspil International Airport lies 29 km from Kiev, and if you would like to see a couple of sights along the way, its best to rent a car and drive yourself. You should remember to keep any documents you get from the airport customs, because you will need them the moment you want to leave the country.
Luxury Hotels in Kiev Ukraine
Accommodation should not give you headaches since Ukraine has numerous state of the art hotels that are certain to suit you. Your budget and perhaps your tastes is what will define the specific type of hotel you are going to choose. In case you have gone with the car rental option, these hotels provide ample parking for your car. Some of the top hotels in Ukraine include;
Hyatt Regency Kiev
It is located in the city center, and strategically situated for tourists aiming at visiting the historic and cultural Kiev's old town, or shopping. It is a hotel with modern amenities like high-speed wireless Internet, on-demand movies among other things.
Radisson Blu Hotel Kiev
It is located a short distance from the city's main street Khreschatyk. It features excellent five-star services along with amenities like cigar bars, fitness center, international cuisine and meeting facilities. It is near business centers, churches, parks and shops. It lies 37 km from Borispil Airport, and you should preferably rent a car at the airport and see a bit of the city on your way to the hotel.
Opera Hotel Kiev
It is situated at the city center, making it strategic for anyone who wants to take in everything Kiev has to offer. It boasts of 137 rooms and seven themed suits of luxury with décor to suit the tastes of all tourists. The luxury suites are based on numerous themes from different countries around the world.
Tourist destinations Ukraine
There are plenty of tours you can make in Ukraine. However, if what you want is a quiet exploration of the country all by yourself, it would be best to go for car hire. If you love adventures, there are ;
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In the month July, The average car rental length in Ukraine was 0 days.
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Adopting a Child of Another Race
What Adoptive Parents Need to Know About Transracial Adoption
Adopting a child of another race is more common now than ever before.
Although not related by blood, children who come home through adoption find love and permanency in a family and have the opportunity to thrive.
Or call 1-800-ADOPTION. Our professionals can answer all of your questions – here we will explore the topic of adopting a child of another race.
Many families considering adoption today are well aware of the fact that adoption could make them a transracial family.
What Does Transracial Adoption Mean, Exactly?
Transracial adoption is when an adoptive family is adopting a child of a different race. Thankfully, this idea is not shocking or new to most people.
It may seem silly to point that out, but we're not that far removed from a very different cultural perception of adopting children of different races. While we're thankful for the progress that has been made concerning transracial families, there's still room for improvement.
Additionally, there's always a need for continued education on the part of parents who are thinking about adopting a child of a different race than their own. Complex challenges attached to race, culture and heritage will come up in this unique parenting journey.
The more open you are to learning about the nuances of adopting a child of another race, the better chance you will have of helping your child thrive.
Prospective birth moms reading this have the opportunity to find adoptive families of a specific race. You can learn more about the process of finding the perfect family for your child by filling out this form to speak to one of our experienced professionals today.
Why it's Important to Talk about Transracial Adoption
We, as Americans, don't love discussing sensitive topics. Race is about as sensitive as it gets. This subject is complex and ever-changing. That's why it is so important to keep an open mind and humble attitude as parents.
It's common to hope that love will cover all.
"We won't need to talk about adopting a child of another race because we will love her just the same."
While your love is never in question, this is not the best approach to adopting a child of a different race. Your love will be the same, but the way they grow up will be different. This doesn't have to be a bad thing — let's celebrate diversity. What we can't afford to do is pretend that diversity of experience due to race doesn't exist.
As parents, it's important to learn about how your child's experience will differ from yours. Then, as is appropriate, do your best to communicate what you've learned and prepare them for the life ahead.
Finding Role Models and Celebrating Heritage
It's best to be proactive when you are a parent. This is true regardless of your family's unique makeup. If you are considering adopting a child of another race, one way to be pro-active is seeking out role models and history for your child that may not be as important to you personally.
If you are a white family adopting a black child, are there Black role models in your community — like pastors, business leaders or coaches — who you can connect with? If you are a Black family adopting a Hispanic baby, how can you help your child maintain an important connection with their heritage?
There are an infinite number of transracial family combinations that we could ask these questions about, but you get the idea. Adopting a different race means embracing two cultures with gusto. This can create a rich environment, and you may find yourself benefiting almost as much as your child.
How Adopting a Child of Another Race Works
Can you adopt a child of another race? Yes, you absolutely can. In fact, transracial adoption is more common than ever before. While it used to be a rare occurrence, the Institute for Family Studies found that transracial adoption increased by 50% from 1999 to 2011.
At American Adoptions, we encourage families to be completely open and honest about what they are OK within their adoption process. For some families, looking like their children may be important. Others may be open (and eager!) to adopting a child of another race. It's totally up to you.
One of the first things you'll do after contacting an adoption specialist to start the process is complete something called an Adoption Planning Questionnaire (APQ). Your APQ will set the boundaries on your adoption — what you are okay with, and what you are not okay with. This includes things like how open your adoption relationship is, the medical history of the prospective birth mother and the race of the child.
While it may seem strange to consider the race of a child as a factor in adoption, it is better to be honest about whether or not you are prepared to take on the challenges that can come with transracial adoption. Not every family is equipped to handle adopting a child of another race and the continued education that comes along with it.
That being said, all families have an opportunity to seek out education, and the more open you can be in your APQ, the better chance you have at experiencing a short adoption wait time.
As far as the rest of the process goes, adopting a child of a different race follows the same steps as any other adoption process.
Learning More about Adopting a Child of Another Race
When it comes to the complex intersection of race, family and culture, you can never stop learning.
Families can educate themselves and their children by:
- Reading books about diversity and race to their children
- Going to social activities where the child can interact with other children of their own race
- Contacting a mentor who is of the same ethnic background as the child
- Talking about race openly and honestly
- Implementing a no-tolerance policy regarding racial or ethnic biased remarks
- Celebrating traditional holidays that are a part of the child's ethnic culture by cooking traditional foods and playing games
- Joining a church that has a diverse congregation
- Becoming more aware of discrimination and addressing these issues openly with the child
- Engaging in activities where individuality and uniqueness in children is encouraged and rewarded
Most importantly, adoptive parents who complete a transracial adoption must be dedicated to providing a home where the family regularly communicates about race and ethnicity and is open about cultural issues and identity.
Have more questions about adopting a child of a different race or the challenges of parenting in a transracial family? Get more free information about adoption online.
If you're a prospective birth mother wanting to place a child for adoption with a family of a certain race, remember to fill out our contact form to connect with a professional today.
Information available through these links is the sole property of the companies and organizations listed therein. American Adoptions provides this information as a courtesy and is in no way responsible for its content or accuracy.


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Broadcast: August 24, 2003
I'm Shirley Griffith.
And I'm Frank Oliver with People in America, a Special English program about people who were important in the history of the United States. Today, we tell about the life of writer Ernest Hemingway.
"A Writer is always alone, always an outsider," Ernest Hemingway said.
Others said that, of the many people he created in his books, Hemingway was his own best creation.
Ernest Hemingway was born in eighteen-ninety-five. He grew up in Oak Park, Illinois, near the middle western city of Chicago. He was the second child in a family of six. His father was a doctor. His mother liked to paint and play the piano.
Each summer, the family travelled to their holiday home in northern Michigan. Ernest's father taught him how to catch fish, hunt, set up a camp and cook over a fire.
At home in Oak Park, Ernest wrote for his school newspaper. He tried to write like a famous sports writer of that time, Ring Lardner. He developed his writing skills this way.
In nineteen-seventeen, Hemingway decided not to go to a university. The United States had just entered World War One and he wanted to join the army. But the army rejected him because his eyesight was not good enough.
Ernest found a job with the Kansas City Star newspaper in Kansas City, Missouri. He reported news from the hospital, police headquarters, and the railroad station. One reporter remembered: "Hemingway liked to be where the action was. "
The Kansas City Star demanded that its reporters write short sentences. It wanted reporters to see the unusual details in an incident. Hemingway quickly learned to do both.
He worked for the newspaper only nine months before he joined the Red Cross to help on the battlefields of Europe. His job was to drive a red cross truck carrying wounded away from battle.
The Red Cross sent him to Italy. Soon he saw his first wounded when an arms factory in Milan exploded. Later, he was sent to the battle front. He went as close to the fighting as possible to see how he would act in the face of danger. Before long, he was seriously wounded.
The war ended soon after he healed. Hemingway returned to the United States. Less than a year had passed since he went to Europe. But in that short time he had changed forever. He needed to write about what he had seen.
Ernest Hemingway left home for Chicago to prove to himself, and to his family, that he could earn a living from his writing.
But, he ran out of money and began to write for a newspaper again. The Canadian newspaper, the Toronto Star, liked his reports about life in Chicago and paid him well.
In Chicago, Hemingway met the writer Sherwood Anderson. Anderson was one of the first writers in America to write about the lives of common people. Hemingway saw that Anderson's stories showed life as it really was, the way Hemingway was trying to do.
Anderson gave Hemingway advice about his writing. He told Hemingway to move to Paris, where living was less costly. He said Paris was full of young artists and writers from all over the world.
In return for Anderson's kindness Hemingway wrote a book called the torrents of spring. It makes fun of Anderson and the way he wrote. There was something in Hemingway that could not say "thank you" to anyone. He had to believe he did everything for himself, even when he knew others helped him.
Hemingway decided to move to Paris. But before he did he married a woman he had recently met. Her name was Hadley Richardson.
Paris was cold and gray when Hemingway and his new wife arrived in nineteen-twenty-one. They lived in one of the poorer parts of the city. Their rooms were small and had no running water. But the Toronto Star employed him as its European reporter, so there was enough money for the two of them to live. And the job gave Hemingway time to write his stories.
Hemingway enjoyed exploring Paris, making new friends, learning French customs and sports. Some new friends were artists and writers who had come to Paris in the nineteen-twenties. Among them were poet, Ezra Pound, and writers Gertrude Stein, John Dos Passos, and F. Scott Fitzgerald. They quickly saw that Hemingway was a good writer. They helped him publish his stories in the United States. He was thankful for their support at the time, but later denied that he had received help.
As a reporter, Hemingway travelled all over Europe. He wrote about politics. He wrote about peace conferences and border disputes. And he wrote about sports, skiing and fishing. Later he would write about bull fighting in Spain. The Toronto Star was pleased with his work, and wanted more of his reports. But Hemingway was busy with his own writing.
He said: "sometimes, I would start a new story and could not get it going. Then I would stand and look out over the roofs of Paris and think. I would say to myself: 'all you have to do is write one true sentence. Write the truest sentence you know. So finally, I would write a true sentence and go on from there. It was a wonderful feeling when I had worked well. "
Hemingway's first book of stories was called in our time. It included a story, called "big two hearted river," about the effect of war on a young man.
It tells about the young man taking a long fishing trip in Michigan. Hemingway had learned from his father when he was a boy about living in the wild.
The story is about two kinds of rivers. One is calm and clear. It is where the young man fishes. The other is dark. It is a swamp, a threatening place.
The story shows the young man trying to forget his past. He is also trying to forget the war. Yet he never really speaks about it. The reader learns about the young man, not because Hemingway tells us what the young man thinks, but because he shows the young man learning about himself.
"Big Two-Hearted River" is considered one of the best modern American stories. It is often published in collections of best writing.
After the book was published in nineteen-twenty-five, Hadley and Hemingway returned to the United States for the birth of their son. They quickly returned to Paris.
Hemingway was working on a long story. He wanted to publish a novel so he would be recognized as a serious writer. And he wanted the money a novel would earn.
The novel was called the sun also rises. It is about young Americans in Europe after World War One. The war had destroyed their dreams. And it had given them nothing to replace those dreams. The writer Gertrude Stein later called these people members of "The Lost Generation. "
The book was an immediate success. At the age of twenty-five Ernest Hemingway was famous.
Many people, however, could not recognize Hemingway's art because they did not like what he wrote about. Hemingway's sentences were short, the way he had been taught to write at the Kansas city star newspaper. He wrote about what he knew and felt. He used few descriptive words. His statements were clear and easily understood.
He had learned from earlier writers, like Ring Lardner and Sherwood Anderson. But Hemingway brought something new to his writing. He was able to paint in words what he saw and felt. In later books, sometimes he missed. Sometimes he even looked foolish. But when he was right he was almost perfect.
With the success of his novel, Hemingway became even more popular in Paris. Many people came to see him. One was an American woman, Pauline Pfeiffer. She became Hadley's friend. Then Pauline fell in love with Hemingway.
Hemingway and Pauline saw each other secretly. One time, they went away together on a short trip. Years later, Hemingway wrote about returning home after that trip:
"When I saw Hadley again, I wished I had died before I ever loved anyone but her. She was smiling and the sun was on her lovely face. "
But the marriage was over. Ernest Hemingway and Hadley separated. She kept their son. He agreed to give her money he earned from his books.
In later years, he looked back at his marriage to Hadley as the happiest time of his life.
This People in America program was written by Richard Thorman. I'm Frank Oliver.
And I'm Shirley Griffith. Join us again next week for the final part of the story of Ernest Hemingway in Special English on the Voice of America.


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Department of Health and Human Services
Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov/)
Components of Participating Organizations
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK/NIH), (http://www.niddk.nih.gov/)
National Cancer Institute (NCI/NIH), (http://www.nci.nih.gov/)
National Heart, Lung, and Blood Institute (NHLBI/NIH), (http://www.nhlbi.nih.gov/)
National Institute on Aging (NIA/NIH), (http://www.nia.nih.gov/)
Title: Pilot and Feasibility Program Related to the Kidney
Announcement Type
This is a reissue of PA-01-127, which was released on August 14, 2001.
Update: The following updates relating to this announcement have been issued:
Program Announcement (PA) Number: PA-05-103
Catalog of Federal Domestic Assistance Number(s)
93.849, 93.396, 93.837, 93.866
Key Dates
Release Date: May 6, 2005
Letters of Intent Receipt Date(s): Not applicable
Application Submission Dates(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm
Peer Review Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm
Council Review Date(s): Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm
Earliest Anticipated Start Date: Standard dates apply, please see http://grants.nih.gov/grants/funding/submissionschedule.htm
Additional Information To Be Available Date (Url Activation Date): Not Applicable
Expiration Date: March 2, 2006
Due Dates for E.O. 12372
Not Applicable
Additional Overview Content
Executive Summary
The Division of Kidney, Urologic and Hematologic Diseases (DKUHD) of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the Division of Cancer Biology of the National Cancer Institute (NCI ), the National Heart, Lung, and Blood Institute (NHLBI) and the Biology of Aging Program of the National Institute on Aging (NIA) invite applications through the exploratory/developmental (R21) grant mechanism from investigators with research interests related to the kidney and fall within the purview of the NIH mission. The primary intent of this initiative is to foster the development of high-risk pilot and feasibility research by newly independent or established investigators, to develop new ideas sufficiently to allow for subsequent submission of R01 applications focusing on research problems relevant to the study of both acute and chronic kidney diseases, and their complications, in both the adult and pediatric populations.
Eligible organizations include: For-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories, units of State and local government, eligible agencies of the Federal government, domestic institutions/organizations.
These grants are not intended to support or supplement ongoing funded research of an established investigator, or to serve as an alternative mechanism of support for projects not receiving funding as competing continuation applications. Eligible principal investigators include all individuals with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.
There is no limit on the number of scientifically distinct applications that may be submitted.
The PHS 398 document is available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. For further assistance contact email@example.com. Telecommunications for the hearing impaired is available at: TTY 301-451-5936.
Table of ContentsPart II Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
Section II. Award Information
1. Mechanism(s) of Support
2. Funds Available
Section III. Eligibility Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Individuals
2.Cost Sharing or Matching
3. Other - Special Eligibility Criteria
Section IV. Application and Submission Information
1. Address to Request Application Information
2. Content and Form of Application Submission
3. Submission Dates and Times
A. Submission, Review and Anticipated Start Dates
1. Letter of Intent
B. Sending an Application to the NIH
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements
Section V. Application Review Information
1. Criteria
2. Review and Selection Process
A. Additional Review Criteria
B. Additional Review Considerations
C. Sharing Research Data
D. Sharing Research Resources
3. Anticipated Announcement and Award Dates
Section VI. Award Administration Information
1. Award Notices
2. Administrative and National Policy Requirements
3. Reporting
Section VII. Agency Contact(s)
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/ Grants Management Contact(s)
Section VIII. Other Information - Required Federal Citations
Part II - Full Text of Announcement1. Research Objectives
The National Institute of Diabetes and Digestive and Kidney Diseases, the National Cancer Institute, the National Heart, Lung, and Blood Institute and the National Institute on Aging invite investigator-initiated high-risk pilot and feasibility research by newly independent or established investigators, to develop new ideas sufficiently to allow for subsequent submission of R01 applications focusing on research problems relevant to the study of both acute and chronic kidney diseases, and their complications, in both the adult and pediatric populations.
Appropriate topics for investigation would include, but are not limited to:
Development of methods to identify and define novel signaling molecules and pathways involved in renal cellular and tissue development, and the genetic programming of renal morphogenesis and angiogenesis.
Development of animal models reflecting the complexity of human kidney diseases, that permits exploration of candidate mechanisms leading to development, injury, and/or tolerance to injury.
Development of less complex models to take advantage of evolutionary-conserved mechanisms involving responses to injury and repair.
Development of new approaches for utilizing mutant organisms for the study of membrane transport.
Crystallization of new regulatory and membrane proteins for study of their structural biology.
Development of technological tools, to improve molecular studies of renal disease, such as methods to permit parallel assessment of gene expression on renal biopsies.
Development of animal models of inflammation/endothelial dysfunction/sepsis leading to kidney disease.
Development of novel vectors and delivery systems for use in gene therapy of systemic and inherited kidney diseases, including disorders such as polycystic kidney disease, diabetic nephropathy, diabetes insipidus, cystinuria, renal hypertension, tubulointerstitial nephropathy, Alport, Bartter's, Gittelman's, Liddle's, and Fanconi syndromes.
Development of new methods to determine the role of complement and complement regulatory proteins, oxidants and proteases, cytokines, chemokines, growth factors, and adhesion molecules and matrix components in immunologic kidney disease.
Combinatorial chemistry for development of new renal reagents.
Identification and characterization of early markers of renal disease severity.
Identification of novel approaches to improve the immediate and long-term outcome in pediatric chronic renal failure.
Development of new methods for temporal and spatial control of transgene expression in the kidney.
Development of micro-methods and miniaturized assays for physiologic and metabolic studies/measurements in small/young animals and children.
Development and use of high-throughput methods, including microarray, proteomic, and phage display technologies, to identify genes and/or proteins expressed in renal tissues in health and disease states, or to characterize overall gene and/or protein expression patterns.
Development of novel strategies for treating progressive renal disease using animal models and/or short term feasibility studies in humans.
Identify new factors contributing to symptoms and morbidity in patients with treated end stage renal disease.
Use of molecular and proteomic techniques on urine, blood or tissue to discover more sensitive markers of chronic renal disease, its progression and response to treatment.
Identification of new pathophysiologic mechanisms and modes of treatment for diabetic nephropathy.
Use of epidemiological and biochemical approaches to identify new, non-traditional risk factors for cardiovascular disease in patients with chronic real disease.
Studies focused on age-related changes in the biology of the kidney and kidney function, and propensity for diseases of the kidney relevant to older subjects.
Studies focused on mechanisms of biological, chemical and physical carcinogenesis and subsequent tumor growth and progression to kidney metastasis.
Use of genetic approaches to identify novel loci contributing to renal disease in humans or animal models, including non-mammalian models.
Identification and optimization of small molecules that specifically modulate the expression or activity of important renal proteins, including: development of assays to screen compound libraries, screens of libraries, and secondary testing of hits recovered in initial screens.
New approaches are needed to investigate the basic mechanisms underlying the association of kidney and cardiovascular diseases in order to develop preventive as well as therapeutic measures to reduce this growing public health problem. Diabetes and hypertension are the leading causes of end-stage renal disease. A better understanding of the etiology of renal injury induced by diabetes and hypertension is critical in order to devise more effective treatments that protect the kidney.
Studies of post-translational modifications such as carbamylation, glycation, acetylation and others of functional and structural proteins including those of the coagulation, and immune systems and their interactions and toxicities.
1. Mechanism(s) of Support
This funding opportunity will use the NIH Exploratory/Development Research Grant ( R21) award mechanism. As an applicant, you will be solely responsible for planning, directing, and executing the proposed project. The R21 award mechanism is to demonstrate feasibility and obtain preliminary data testing innovative ideas that represent a clear departure from ongoing research interests. Detailed instructions for preparing the R21 may be found at: http://grants.nih.gov/grants/guide/pa-files/PA-03-107.html
The grants will not be renewable; continuation of projects developed under this program will be through the regular research project grant (R01) program.
This funding opportunity uses just-in-time concepts. It also uses the modular budget format described in the PHS 398 application instructions (see http://grants.nih.gov/grants/funding/modular/modular.htm).
2. Funds Available
The total amount to be awarded and the anticipated number of awards will depend upon the quality of the applications received. For R21 awards, you may request a project period of up to two years with a combined budget for direct costs of up $275,000 for the two year period. For example, you may request $100,000 in the first year and $175,000 in the second year. Normally, no more than $200,000 may be requested in any single year. For information on R21 mechanism, see http://grants.nih.gov/grants/guide/pa-files/PA-03-107.html.
Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the IC(s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications.
Facilities and administrative costs requested by consortium participants are not included in the direct cost limitation, see http://grants.nih.gov/grants/guide/notice-files/NOT-OD-05-004.html.
Section III. Eligibility Information1. Eligible Applicants
1.A. Eligible Institutions
You may submit (an) application(s) if your organization has any of the following characteristics:
1.B. Eligible Individuals
Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.
2. Cost Sharing or Matching
The most current Grants Policy Statement can be found at: http://grants.nih.gov/grants/policy/nihgps_2003/nihgps_Part2.htm#matching_or_cost_sharing.
3. Other-Special Eligibility Criteria
Not applicable
1. Address to Request Application Information
The PHS 398 application instructions are available at http://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: firstname.lastname@example.com.
Telecommunications for the hearing impaired: TTY 301-451-5936.
2. Content and Form of Application Submission
Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling (866) 705-5711 or through the web site at http://www.dnb.com/us/. The D&B number should be entered on line 11 of the face page of the PHS 398 form.
The title and number of this funding opportunity must be typed on line 2 of the face page of the application form and the YES box must be checked.
Foreign Organizations
Several special provisions apply to applications submitted by foreign organizations:
Proposed research should provide a unique research opportunity not available in the U.S.
3. Submission Dates and Times
Applications must be mailed on or before the receipt date described below (Section IV.3.A). Submission times N/A.
3.A. Submission, Review and Anticipated Start Dates
Application Submission Date(s):Standard dates, please see: http://grants.nih.gov/grants/funding/submissionschedule.htm
Peer Review Date: Standard dates, please see: http://grants.nih.gov/grants/funding/submissionschedule.htm
Council Review Date: Standard dates, please see: http://grants.nih.gov/grants/funding/submissionschedule.htm
Earliest Anticipated Start Date: Standard dates: please see: http://grants.nih.gov/grants/funding/submissionschedule.htm
3.B. Sending an Application to the NIH
Applications must be prepared using the PHS 398 research grant application instructions and forms as described above. Submit a signed, typewritten original of the application, including the checklist, and five signed photocopies in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)
Personal deliveries of applications are no longer permitted (see http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-040.html).
3.C. Application Processing
Applications must be submitted on or before the application receipt/submission dates described above (Section IV.3.A.) and at http://grants.nih.gov/grants/dates.htm.
Upon receipt, applications will be evaluated for completeness by CSR. Incomplete applications will not be reviewed.
The NIH will not accept any application in response to this funding opportunity that is essentially the same as one currently pending initial review unless the applicant withdraws the pending application. The NIH will not accept any application that is essentially the same as one already reviewed. This does not preclude the submission of a substantial revision of an application already reviewed, but such application must include an Introduction addressing the previous critique.
Although there is no immediate acknowledgement of the receipt of an application, applicants are generally notified of the review and funding assignment within eight (8) weeks.
4. Intergovernmental Review
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The Grants Policy Statement can be found at http://grants.nih.gov/grants/policy/policy.htm.
Pre-Award Costs are allowable. A grantee may, at its own risk and without NIH prior approval, incur obligations and expenditures to cover costs up to 90 days before the beginning date of the initial budget period of a new or competing continuation award if such costs: are necessary to conduct the project, and would be allowable under the grant, if awarded, without NIH prior approval. If specific expenditures would otherwise require prior approval, the grantee must obtain NIH approval before incurring the cost. NIH prior approval is required for any costs to be incurred more than 90 days before the beginning date of the initial budget period of a new or competing continuation award.
The incurrence of pre-award costs in anticipation of a competing or non-competing award imposes no obligation on NIH either to make the award or to increase the amount of the approved budget if an award is made for less than the amount anticipated and is inadequate to cover the pre-award costs incurred. NIH expects the grantee to be fully aware that pre-award costs result in borrowing against future support and that such borrowing must not impair the grantee's ability to accomplish the project objectives in the approved time frame or in any way adversely affect the conduct of the project. See NIH Grants Policy Statement http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part6.htm.
6. Other Submission Requirements
Specific Instructions for Modular Grant applications.
Applications requesting up to $250,000 per year in direct costs must be submitted in a modular budget format. The modular budget format simplifies the preparation of the budget in these applications by limiting the level of budgetary detail. Applicants request direct costs in $25,000 modules. Section C of the research grant application instructions for the PHS 398 at http://grants.nih.gov/grants/funding/phs398/phs398.html includes step-by-step guidance for preparing modular budgets. Applicants must use the currently approved version of the PHS 398. Additional information on modular budgets is available at http://grants.nih.gov/grants/funding/modular/modular.htm.
Plan for Sharing Research Data
The precise content of the data-sharing plan will vary, depending on the data being collected and how the investigator is planning to share the data. Applicants who are planning to share data may wish to describe briefly the expected schedule for data sharing, the format of the final dataset, the documentation to be provided, whether or not any analytic tools also will be provided, whether or not a data-sharing agreement will be required and, if so, a brief description of such an agreement (including the criteria for deciding who can receive the data and whether or not any conditions will be placed on their use), and the mode of data sharing (e.g., under their own auspices by mailing a disk or posting data on their institutional or personal website, through a data archive or enclave). Investigators choosing to share under their own auspices may wish to enter into a data-sharing agreement. References to data sharing may also be appropriate in other sections of the application.
All applicants must include a plan for sharing research data in their application. The data sharing policy is available at http://grants.nih.gov/grants/policy/data_sharing. All investigators responding to this funding opportunity should include a description of how final research data will be shared, or explain why data sharing is not possible.
The reasonableness of the data sharing plan or the rationale for not sharing research data will be assessed by the reviewers. However, reviewers will not factor the proposed data sharing plan into the determination of scientific merit or the priority score.
Sharing Research Resources
NIH policy requires that grant awardee recipients make unique research resources readily available for research purposes to qualified individuals within the scientific community after publication (NIH Grants Policy Statement http://grants.nih.gov/grants/policy/nihgps_2003/index.htm and http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part7.htm#_Toc54600131). Investigators responding to this funding opportunity should include a plan for sharing research resources addressing how unique research resources will be shared or explain why sharing is not possible.
The adequacy of the resources sharing plan and any related data sharing plans will be considered by Program staff of the funding organization when making recommendations about funding applications. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590, http://grants.nih.gov/grants/funding/2590/2590.htm). See Section VI.3. Reporting.
Section V. Application Review Information1. Criteria
Only the review criteria described below will be considered in the review process.
2. Review and Selection Process
Applications submitted for this funding opportunity will be assigned to the ICs on the basis of established PHS referral guidelines.
Appropriate scientific review groups convened in accordance with the standard NIH peer review procedures (http://www.csr.nih.gov/refrev.htm) will evaluate applications for scientific and technical merit.
As part of the initial merit review, all applications will:
The following will be considered in making funding decisions:
The goals of NIH supported research are to advance our understanding of biological systems, to improve the control of disease, and to enhance health. In their written critiques, reviewers will be asked to comment on each of the following criteria in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that an application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward.
1. Significance. Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? What will be the effect of these studies on the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
2. Approach. Are the conceptual or clinical framework, design, methods, and analyses adequately developed, well integrated, well reasoned, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics?
3. Innovation. Is the project original and innovative? For example: Does the project challenge existing paradigms or clinical practice; address an innovative hypothesis or critical barrier to progress in the field? Does the project develop or employ novel concepts, approaches, methodologies, tools, or technologies for this area?
4. Investigators. Are the investigators appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers? Does the investigative team bring complementary and integrated expertise to the project (if applicable)?
5. Environment. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed studies benefit from unique features of the scientific environment, or subject populations, or employ useful collaborative arrangements? Is there evidence of institutional support?
2.A. Additional Review Criteria:
In addition to the above criteria, the following items will continue to be considered in the determination of scientific merit and the priority score:
Protection of Human Subjects from Research Risk: The involvement of human subjects and protections from research risk relating to their participation in the proposed research will be assessed (see the Research Plan, Section E on Human Subjects in the PHS Form 398).
Inclusion of Women, Minorities and Children in Research: The adequacy of plans to include subjects from both genders, all racial and ethnic groups (and subgroups), and children as appropriate for the scientific goals of the research will be assessed. Plans for the recruitment and retention of subjects will also be evaluated (see the Research Plan, Section E on Human Subjects in the PHS Form 398).
Care and Use of Vertebrate Animals in Research: If vertebrate animals are to be used in the project, the five items described under Section F of the PHS Form 398 research grant application instructions will be assessed.
2.B. Additional Review Considerations
Budget: The reasonableness of the proposed budget and the requested period of support in relation to the proposed research. The priority score should not be affected by the evaluation of the budget.
2.C. Sharing Research Data
Data Sharing Plan: The reasonableness of the data sharing plan or the rationale for not sharing research data will be assessed by the reviewers. However, reviewers will not factor the proposed data sharing plan into the determination of scientific merit or the priority score. The presence of a data sharing plan will be part of the terms and conditions of the award. The funding organization will be responsible for monitoring the data sharing policy.
2.D. Sharing Research Resources
The adequacy of the resources sharing plan will be considered by Program staff of the funding organization when making recommendations about funding applications. Program staff may negotiate modifications of the data and resource sharing plans with the awardee before recommending funding of an application. The final version of the data and resource sharing plans negotiated by both will become a condition of the award of the grant. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590). See Section VI.3. Reporting.
3. Anticipated Announcement and Award Dates
Not applicable
1. Award Notices
After the peer review of the application is completed, the Principal Investigator will also receive a written critique called a Summary Statement.
If the application is under consideration for funding, NIH will request "just-in-time" information from the applicant. For details, applicants may refer to the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General (http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_part4.htm).
A formal notification in the form of a Notice of Grant Award (NGA) will be provided to the applicant organization. The NGA signed by the grants management officer is the authorizing document. Once all administrative and programmatic issues have been resolved, the Notice of Grant Award will be generated via email notification from the awarding component to the grantee business official (designated in item 14 on the Application Face Page). If a grantee is not email enabled, a hard copy of the Notice of Grant Award will be mailed to the business official.
Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NGA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. See Also Section IV.5. Funding Restrictions.
2. Administrative and National Policy Requirements
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the notice of grant award. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General (http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part4.htm) and Part II Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities (http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_part9.htm).
Awardees will be required to submit the PHS Non-Competing Grant Progress Report, Form 2590 annually (http://grants.nih.gov/grants/funding/2590/2590.htm) and financial statements as required in the NIH Grants Policy Statement.
Section VII. Agency ContactsWe encourage your inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants. Inquiries may fall into three areas: scientific/research, peer review, and financial or grants management issues:
1. Scientific/Research Contacts:
Chris Ketchum, PhD
Division of Kidney, Urology and Hematology
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd., Room 647
Bethesda, MD 20892-5458
Telephone: (301) 594-7717
Fax: (301) 480-3510
Email: firstname.lastname@example.com
Judy Mietz, PhD
DNA and Chromosome Aberrations Branch
National Cancer Institute
Executive Plaza North, Room 5028
Rockville, MD 20852
Telephone: (301) 496-9326
Fax: (301) 496-1224
Email: email@example.com
Winnie Barouch, PhD
Division of Heart and Vascular Diseases
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Suite 10193
Bethesda, MD 20892-7956
Telephone: (301) 435-0560
Fax (301) 480-2849
Email: email@example.com
Frank Bellino, PhD
Biology of Aging Program
National Institute on Aging
Gateway Building, Suite 2C231
7201 Wisconsin Ave.
Bethesda, MD 20892-9205
Telephone: (301) 496-6402
Email: firstname.lastname@example.com
2. Peer Review Contacts:
Not applicable
3. Financial or Grants Management Contacts:
Helen Ling
Grants Management Branch
National Institute of Diabetes and Digestive and Kidney Diseases
6707 Democracy Blvd., Room 647
Bethesda, MD 20892-5456
Telephone: (301) 594-8857
Email: firstname.lastname@example.com
Shelia Ortiz
Grants Operations Branch
National Heart, Lung, and Blood Institute
6701 Rockledge Drive
Room 7171 MSC 7926
Bethesda, MD 20892-7926
Telephone: (301)435-0166
Fax: (301)480-3310
Email: firstname.lastname@example.com
Deborah Stauffer
Lead Grants Management Specialist
National Institute on Aging
Gateway Building, Suite 2N212
7201 Wisconsin Ave.
Bethesda, MD 20892-9205
Telephone: (301) 496-1472
Email: firstname.lastname@example.com
Required Federal Citations
Use of Animals in Research:
Recipients of PHS support for activities involving live, vertebrate animals must comply with PHS Policy on Humane Care and Use of Laboratory Animals (http://grants.nih.gov/grants/olaw/references/PHSPolicyLabAnimals.pdf) as mandated by the Health Research Extension Act of 1985 (http://grants.nih.gov/grants/olaw/references/hrea1985.htm), and the USDA Animal Welfare Regulations (http://www.nal.usda.gov/awic/legislat/usdaleg1.htm) as applicable.
Human Subjects Protection:
Federal regulations (45CFR46) require that applications and proposals involving human subjects must be evaluated with reference to the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm).
Data and Safety Monitoring Plan:
Data and safety monitoring is required for all types of clinical trials, including physiologic toxicity and dose-finding studies (phase I); efficacy studies (Phase II); efficacy, effectiveness and comparative trials (Phase III). Monitoring should be commensurate with risk. The establishment of data and safety monitoring boards (DSMBs) is required for multi-site clinical trials involving interventions that entail potential risks to the participants (NIH Policy for Data and Safety Monitoring, NIH Guide for Grants and Contracts, http://grants.nih.gov/grants/guide/notice-files/not98-084.html).
Sharing Research Data:
Investigators submitting an NIH application seeking $500,000 or more in direct costs in any single year are expected to include a plan for data sharing or state why this is not possible (http://grants.nih.gov/grants/policy/data_sharing).
Investigators should seek guidance from their institutions, on issues related to institutional policies and local IRB rules, as well as local, State and Federal laws and regulations, including the Privacy Rule. Reviewers will consider the data sharing plan but will not factor the plan into the determination of the scientific merit or the priority score.
Sharing of Model Organisms:
NIH is committed to support efforts that encourage sharing of important research resources including the sharing of model organisms for biomedical research (see http://grants.nih.gov/grants/policy/model_organism/index.htm). At the same time the NIH recognizes the rights of grantees and contractors to elect and retain title to subject inventions developed with Federal funding pursuant to the Bayh Dole Act (see the NIH Grants Policy Statement http://grants.nih.gov/grants/policy/nihgps_2003/index.htm). All investigators submitting an NIH application or contract proposal, beginning with the October 1, 2004 receipt date, are expected to include in the application/proposal a description of a specific plan for sharing and distributing unique model organism research resources generated using NIH funding or state why such sharing is restricted or not possible. This will permit other researchers to benefit from the resources developed with public funding. The inclusion of a model organism sharing plan is not subject to a cost threshold in any year and is expected to be included in all applications where the development of model organisms is anticipated.
Inclusion of Women And Minorities in Clinical Research:
It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported clinical research projects unless a clear and compelling justification is provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing clinical research should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research (http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); a complete copy of the updated Guidelines is available at http://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm. The amended policy incorporates: the use of an NIH definition of clinical research; updated racial and ethnic categories in compliance with the new OMB standards; clarification of language governing NIH-defined Phase III clinical trials consistent with the new PHS Form 398; and updated roles and responsibilities of NIH staff and the extramural community. The policy continues to require for all NIH-defined Phase III clinical trials that: a) all applications or proposals and/or protocols must provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) investigators must report annual accrual and progress in conducting analyses, as appropriate, by sex/gender and/or racial/ethnic group differences.
Inclusion of Children as Participants in Clinical Research:
The NIH maintains a policy that children (i.e., individuals under the age of 21) must be included in all clinical research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them.
All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the inclusion of children as participants in research involving human subjects (http://grants.nih.gov/grants/funding/children/children.htm).
Required Education on the Protection of Human Subject Participants:
NIH policy requires education on the protection of human subject participants for all investigators submitting NIH applications for research involving human subjects and individuals designated as key personnel. The policy is available at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
Human Embryonic Stem Cells (hESC):
Criteria for federal funding of research on hESCs can be found at http://stemcells.nih.gov/index.asp and at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html. Only research using hESC lines that are registered in the NIH Human Embryonic Stem Cell Registry will be eligible for Federal funding (http://escr.nih.gov/). It is the responsibility of the applicant to provide in the project description and elsewhere in the application as appropriate, the official NIH identifier(s) for the hESC line(s)to be used in the proposed research. Applications that do not provide this information will be returned without review.
Public Access to Research Data through the Freedom of Information Act:
The Office of Management and Budget (OMB) Circular A-110 has been revised to provide public access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at http://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this PA in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award.
Standards for Privacy of Individually Identifiable Health Information:
The Department of Health and Human Services (DHHS) issued final modification to the "Standards for Privacy of Individually Identifiable Health Information", the "Privacy Rule", on August 14, 2002. The Privacy Rule is a federal regulation under the Health Insurance Portability and Accountability Act (HIPAA) of 1996 that governs the protection of individually identifiable health information, and is administered and enforced by the DHHS Office for Civil Rights (OCR).
Decisions about applicability and implementation of the Privacy Rule reside with the researcher and his/her institution. The OCR website (http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including a complete Regulation Text and a set of decision tools on "Am I a covered entity?" Information on the impact of the HIPAA Privacy Rule on NIH processes involving the review, funding, and progress monitoring of grants, cooperative agreements, and research contracts can be found at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs in NIH Grant Applications or Appendices:
All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Furthermore, we caution reviewers that their anonymity may be compromised when they directly access an Internet site.
Healthy People 2010:
The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This PA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople.
Authority and Regulations:
This program is described in the Catalog of Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The NIH Grants Policy Statement can be found at http://grants.nih.gov/grants/policy/policy.htm.
The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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NIH Funding Opportunities and Notices
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Wells Fargo & Company is a diversified financial services company providing banking, insurance, investments, mortgage and consumer finance to more than 23 million customers from more than 6,000 stores and the internet (wellsfargo.com) across North America and elsewhere internationally. Wells Fargo Bank, N.A. is the only ''Aaa'' rated bank in the United States.


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Bitter: Spending a month away from home
Sweet: Spending time at Dan and Darlene's home
Bitter: Being away from Andy (aka "Daddy")
Sweet: We'll be able to see Andy on the weekends
Bitter: Not seeing Elijah's therapists and doctors for a month
Sweet: Meeting new people and therapists who might have innovative ideas
Bitter: Not having quality time with Andy
Sweet: Quality time with Dan and Darlene, Grandpa Dennis
Bitter: We'll miss everyone from home
Sweet: Who knows how much Elijah might change in the next month with HBOT and therapy!
I feel so bittersweet about leaving for therapy. Excited, yes, but sad to leave home. Can't wait to see what kind of changes the next month will bring for our little man, but sad we won't be able to see Andy everyday. We'll leave tomorrow and we start therapy on Monday. Please keep us in your prayers.


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Charlie Murder
M (Mature)
- Online Interactions Not Rated by the ESRB
It's a punk rock apocalypse! Team up with your friends to lead embattled punk rock band Charlie Murder in their epic quest to save the world from rival death metalers Gore Quaffer and their legions of evil. RPG it up as you hoard insane loot to buff your character (and look excellent), earn fans to unlock powerful finishers and teamup moves, get tattoos to channel your "Anar-Chi," and uncover mysterious relics of modern myth!
- 6/4/2013
- Ska Studios
- Microsoft Studios
- Fighting, Platformer
- Offline co-op 2 - 4
- Dolby Digital
Online features
- Online multiplayer 2 - 4
- Online co-op 2 - 4
- Leaderboards
- Voice chat
Get it here. Play it there.
Buy Xbox content on Xbox.com. Your Xbox 360 console will automatically download the content next time you turn it on and connect to Xbox Live.
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Claudio Reyna: 'It all ties into style of play'
Claudio Reyna: 'It all ties into style of play'
Interview by Mike Woitalla
As U.S. Soccer's Youth Technical Director, Claudio Reyna believes a key to improving American player development is convincing more youth clubs to strive for a style of play conducive to nurturing talent. The 78-club U.S. Soccer Development Academy, which kicked off its fifth season this month, is a integral part of the national team program's quest to improve American soccer. We spoke with Reyna about the process …
SOCCER AMERICA: I'd say that the USA produces many more good players than ever but doesn't produce truly exceptional, creative players at a better rate than it did 20, even 30 years ago. Would you agree?
CLAUDIO REYNA: To a certain degree. There's a bigger pool of players. I like some players who stand out at certain age groups – whose names I'd rather not mention to keep them level headed. But, absolutely, we could use some more exceptional players.
On the one side the average player has improved over the last 10 to 20 years, but if you look at the top-tier players — we can definitely push ourselves to increase the number of those, and it's the coaches who can make that happen.
SA: What can coaches do?
CLAUDIO REYNA: We have to make sure we nurture those players in the right way because sometimes they haven't been given a chance — maybe because of the style of play or because of a particular coach.
I believe a Wesley Sneijder would have never developed in an ugly style of play. He grew up in a country [Netherlands] where he was allowed to flourish and play, and that goes for all the Spanish players, all the great German players, all the great Argentine and Brazilian players.
It really all ties back to style of play — if we don't make sure it's a good style of play, potentially great players are going to get lost in the helter-skelter, fast type of soccer.
If we encourage a much better style of play, then those players will enjoy playing in that environment and will be able to shine.
In my opinion, sometimes the soccer is quite ugly to watch — you can't even spot the talented player because he's caught up in that type of game.
That's one of the reasons a better style of play at the youth level will help the individuals coming up.
SA: Thanks to the U.S. Soccer Development Academy, the Federation has influence over 78 clubs who field teams at both the U-15/16 and U-17/18 level. Can you give me an example of what you and the Federation staff look for when evaluating an Academy club?
CLAUDIO REYNA: We look at how a team is trying to play. There are certain styles of play we're trying to get away from.
For example, we're trying to have the teams play quick but want to make sure there's a thought process going on. Sometimes we have teams playing quick, but it's very helter-skelter — and we want to try and change that.
Sometimes we have teams that play really well with the right ideas in their head, but yet they do it too slow.
SA: Give us an example of a key thing you're looking for when you go to a youth game that reveals the coaches are on the wrong track when it comes to style-of-play …
CLAUDIO REYNA: There are specific topics we talk about from the technical and tactical that we like to see. One, for example, is the emphasis of playing out of the back – from the goalie and the back four.
It takes about 10 or 15 minutes to notice a goalkeeper gets the ball and punts it every time he has the ball. The four defenders turn their back every time the goalkeeper gets the ball and run upfield because they know he's punting.
That shows me right away there isn't enough emphasis at the club to train playing out of the back.
The ones who lose out ultimately are the players, because a defender, at one point, especially at the national team level, is going to need the skills to play out of the back. It's going to be difficult to develop central backs if all they're doing their entire career is kicking the ball up as far as they can, heading it as far as they can.
Emphasizing that we're looking for them to play out of the back, through the midfield, in turn will develop more midfield players who are used to receiving the ball from the defenders.
SA: Encouraging young players to play possession ball in their own half is risky because they'll give up goals – and lose games. Is it the Federation's belief that by evaluating clubs on style of play it will alleviate the pressure on coaches to resort to a results-driven approach?
CLAUDIO REYNA: Yes, and the idea is that the club should be focusing on training this at the young ages so by the time they get to U-14, U-15, U-16, they're very comfortable playing out of the back.
There are many clubs that are doing a very good job, trying to promote playing the right way. We're lucky to have good examples to follow and we reward and highlight them.
The easy way, absolutely, to play for wins at the younger ages is to tell the goalie to kick it up the field, and everytime there's a throw-in or a free kick, to send it to the corner and everyone chases it, but I don't think I'm unveiling any secrets when I say that's not going to develop players.
You're not going to get results all the time encouraging your young players to play out of the back, but you're going to get better players. And I believe, in the long-term, you're going to have better teams.
(Claudio Reyna was named the U.S. Soccer Federation's Youth Technical Director in April 2010. Reyna played nearly 13 years in the top-tier leagues of Germany (Bayer Leverkusen, VfL Wolfsburg), Scotland (Glasgow Rangers) and England (Sunderland, Manchester City). He represented the USA in four World Cups, and captained the Americans to a quarterfinal run at the 2002 World Cup, where he became the first American selected to the FIFA World Cup all-star team.)
Team Record
Mon, Jun 05 | vs. Team Chicago-2005... | ( Stats ) |
Sun, May 28 | at Memorial Day Tour... | ( Stats ) |
Sat, May 27 | at Memorial Day Tour... | ( Stats ) |
Wed, May 17 | at WC lions | ( Stats ) |
Sat, May 13 | vs. Team Chicago-2005... | ( Stats ) |


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Designer: OneWay Ranchwear
Show off your boho chic style with this women's leather cuff bracelet!
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Photos: Poppy Delevingne; Courtesy of Rex Features, Splash News.
This is my ideal travel outfit which marries trend and function, allowing us adapt to temperature changes between takeoff and landing with ease. I love how Poppy Delevingne made the soon-to-be-everywhere western elements (the fringes and flowers) city-centered with a leather jacket, sneaker and sweatshirt.
Clockwise from top left:
Jacket: BLK DNM (love the quilted sleeves! similar here)
Sunglasses: House of Harlow 1960
Sweatshirt: Zoe Karssen (my go-to brand for off-duty essentials! on Delevingne here)
Short: Free People ($32 here)
Sneaker: Converse
Bag: Gucci (similar here & here)
Sandal: Sam Edelman


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Perfect automation solution for the electronics industry
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