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Need attractive business signs to grow your business and improve your bottom line? Denver Signs & Graphics is the right partner for you!
A full-service Denver sign company, Denver Signs & Graphics is your local partner for impressive signage that gets your business noticed. Regardless of your marketing goals or business size, we will design, manufacture, and install the attractive signage you need.
From retractable tradeshow banners to towering pole signs, ADA signs to A-frames, we can create individual signage elements for business promotion or identification or an entire cohesive signage collection that highlights your brand and gets you noticed. Our dedicated staff of expert sign professionals understands the unique needs of your business. We are ready to get to work on your signage project, delivering impactful custom signage that meets your needs, timeframe, and budget.
Call Denver Signs & Graphics at (720) 664-8954 for your Free Consultation!
Cohesive Commercial Signs
To stand out in the competitive Denver market, you need to arm your business with well-crafted, attractive commercial signage. Aside from providing your logo and business name, custom business signs and graphics provide information that your potential and existing customers need, such as your current promotions, hours of operation, or ADA and accessibility information.
The combination of signage that you choose for your business will not only provide information; it will also compel new visitors to enter and past customers to return by reinforcing your brand personality and highlighting your highest margin or most popular products and services. Denver Signs & Graphics is dedicated to helping Denver business owners build their business by providing the commercial signage needed to increase their brand presence and visibility in an ever-growing market.
Our comprehensive range of signage products and services make it easy for you to promote special deals, product launches, marketing events, and more. Denver Signs & Graphics crafts branded storefront signs for businesses that tell potential customers who you are and what you have to offer.
The right combination of permanent business identification signage and temporary promotional signage helps increase your brand visibility and jumpstart your business growth.
Complete Business Signage
Your outdoor signage is responsible for attracting visitors into your facility. Your indoor signage is responsible for ensuring they have a positive experience while on site. Not only should it reinforce your brand and provide effective wayfinding support, your interior signage should also allow your customers to sell themselves on your products and services. Your blend of indoor signage can include many different elements, but will commonly include items like vinyl graphics and banners, ADA signs, wayfinding signage, lobby signage, promotional and point of purchase signs, and more.
Whether you need a single signage element or an entire business signage package, Denver Signs & Graphics has the tools, resources, and knowledge to create the high-impact signage your business needs and deserves.
Our business sign services include:
You may require new signage for special events, season changes, or new products. Whatever your needs, Denver Signs & Graphics has the ability and desire to handle any of your unique signage challenges. Whether you need branded indoor signs and outdoor signs, custom signage, or vehicle wraps, we are ready to deliver for you. If you desire a dedicated, experienced partner to assist with signage jobs both large and small, Denver Signs & Graphics is the right sign company for your needs.
Free Business Signs Consultation
Business signs and graphics are the main way that new customers learn about your business, brand, and what you can do for them. Attractive, professional commercial signage sets your business apart from all of the other businesses and distractions that compete for your potential customers' attention. Whether you want to stand out from businesses around you or want to entice potential customers to look up from their devices for just a moment, we can help you to accomplish those goals with impactful signage that can't be missed.
As a full-service Denver, CO signage provider, Denver Signs & Graphics handles every aspect of your signage project, providing professional sign design, manufacturing, installation, and repair or maintenance to ensure your business is sending an attractive, cohesive message to all potential customers throughout all potential marketing channels. Let Denver Signs & Graphics be your complete signage provider!
Call Denver Signs & Graphics at (720) 664-8954 for your Free Consultation with a Business Signage Specialist!


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Author Fred Strebeigh discusses his new book Equal: Women Reshape American Law on Thursday, May 28, at 6:30 p.m. at the Central Library, 14 W. 10th St.
As late as 1967, men outnumbered women twenty to one in American law schools. During the Vietnam War, more law schools admitted women to avoid plummeting enrollments. As women entered, the law resisted. Judges would not hire women. Law firms asserted a right to discriminate against women. Judges permitted discrimination against pregnant women. Courts viewed sexual harassment as, one judge said, "a game played by the male supervisors."
Against the odds, women fought to reshape the law. Fred Strebeigh has interviewed litigators, plaintiffs, and judges, including Ruth Bader Ginsburg and Catharine MacKinnon, and researched in their private archives as well as those of other attorneys who took cases to the Supreme Court to make the law equal and just for all.
Strebeigh has written for The Atlantic, Smithsonian, and The New York Times Magazine. He teaches nonfiction writing at Yale University.
Admission is free. Click here or call 816.701.3407 to RSVP. A 6 p.m. reception precedes the event. Free parking is available in the Library District Parking Garage at 10th and Baltimore.

subset: commoncrawl


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New magical, fantasy romance…with a twist from Sabrina York
Wicked Enchantment
By Sabrina York
Read on for an exclusive excerpt and a chance to WIN the
Wicked Enchantment Tiara
Consigned to a magical prison, Sir Keeshan has suffered torment after torment for thousands of years. The curse of a powerful Djinn entombed him in the lamp, damning him to an eternity of pleasing the women who come to him—but never grasping true love. Every hundred years or so, a new woman comes to him and they are both are ensnared in a web of dark desire. And then, just as he grows to care for her, she is spirited away, back to the world. Such is the nature of his curse.
But when Aimalee arrives, Keeshan knows something is different. She is different. And his feelings for her are undeniable. He has no idea how long they will have together and, desperate to not waste a second of his time with her, Keeshan cannot help but indulge his every craving…and hers.
When the clever minx helps him solve a mystery that has been haunting him for ages, he can't help but hope she may be the one to help him break the curse.
Hope is a dangerous thing in enchanted surrounds, especially because he knows her departure, when it comes, will destroy him.
Magical, fantasy romance…with a twist from Sabrina York
18+ Only
Aimalee shivered as an unfamiliar inclination struck her. She wanted to drop the pillow and press her body against him. Rub against him. He was so beautiful. So perfect. She longed to touch him.
Of its own volition, her hand rose. At the last instant, just before their flesh connected, she curled her fingers.
He winced as she withdrew, winced as though she'd slapped him. Tiny tears clung to his lashes. "Please, Aimalee." His voice was ragged. "Please touch me."
She stepped away, ignoring the desolation sweeping across his countenance. It cost her but she forced those primal urges down, back into her subconscious where they belonged. Something wasn't right here. Women didn't just suddenly transport into sumptuous bowers. Gorgeous men with smoldering eyes didn't simply appear from thin air. And most importantly, Aimalee didn't have thoughts like this.
She never had.
She couldn't give in to these cravings. Not until she understood what was happening to her. Her analytical mind would not allow it.
As though he could read her thoughts, a frown marred his sculpted brow in fascinating furrows. He stepped closer and closer still—though not close enough to touch. His breath was warm on her face. "Don't fight it, Aimalee. You cannot resist. Please don't try." He bent closer and his nostrils flared like a stallion catching the scent of a filly in season. He licked his lips.
My but they were beautiful lips.
And my, oh my. He smelled of sandalwood and sin. The combination made her head spin. She desperately attempted to eradicate these errant thoughts. "Where am I? What happened?" More questions swirled but this was a good place to start.
"Please." Beads of sweat dimpled his upper lip. Heat roiled from his broad chest. Everything about him was hard. "Not now. No questions now." He whirled away with a growl, showing her his back, frustration clear in every rigid line. As he moved, the dim light glinted off the metal encircling his neck. Aimalee realized it was hewn of the same strange iridescent metal of the lamp.
Certainty dawned and with it a sense of incredulity. "I'm inside the lamp."
He shot a glance at her over his hunched shoulder, a wounded animal. "Y-you touched it."
"I've touched it many times before."
"Many times." A shudder racked him. He began to shiver, to shake. "But never with…never with…" Never with…what? He didn't complete the thought, as though the words were too painful to utter. He moaned in agony and stumbled into the shadows.
She followed, racked with worry—he looked as though he was dying—and lightly touched his shoulder. He froze at the contact, sucking in a deep gasp of air, exhaling it on a small whimper. As their flesh connected, a sizzle shot up her arm, rocketing to her core. Something tight within her released.
And then she realized…the release hadn't come from within her.
It had come from within him.
Invisible chains binding him shattered and fell away.
He straightened and stood. Sublime relief descended upon him like a cloud. "Thank you," he gasped. "Thank you, Aimalee." He drew his knuckles along the curve of her shoulder then trailed down her arm, sending riots of sensation through her. "You touched it with your bare hands, you see. And the lamp brought you to me," he said, answering her earlier—long forgotten—question. He caressed her hand, lifted it to his lips then drew her thumb into his mouth and gently sucked.
Molten lava, deep in her core, churned and spat.
She knew she should not allow this. She knew she should pull away. The voice of sanity within her whispered as much. Trouble was, that voice of sanity was starting to recede. "W-why?" It was the only word she could manage. The only thought she could conjure.
He kissed her knuckles, one by one. "You are here for me, Aimalee. For this." His scalding touch trailed back up her arm. She jerked in reaction but didn't protest. Her body was heavy, drugged with desire. Her mind befuddled, rapt in it. Enthralled.
He tugged gently at the pillow she held before her. She watched in mute dismay as he tossed her armor carelessly aside. "God, Aimalee. You are even more beautiful in the flesh."
Reverently, he cupped her breast. And then his head descended and those lips—those delicious lips—wrapped around a coral crest. Sucked. Pleasure rocked her. Exquisite trills danced along her spine. Tremors rippled through her womb.
But still…she resisted. As difficult as it was to fight against the alluring enchantment he was weaving—and it was difficult—she lurched back and gasped, "Who are you?"
Instead of answering, he scraped her nipple—sending spirals of delight coiling up her spine. Oh! It was getting harder and harder to resist him. Harder to focus on her outrage as he enticed her deeper into his web.
But she was not the only one besieged by temptation. His body was taut as a bowstring; he fairly hummed with the tension.
He pulled her into his arms. The shock of his hot skin against hers from chest to groin made her light-headed. He traced the line of her back from her buttocks to her shoulder blades.
"I am sorry, Aimalee," he murmured, his tone limned with remorse. "But I cannot answer your questions anymore. I cannot wait. It has been far too long." He lifted her hair and bent to place a gentle kiss on her nape. With his tongue, his velvet, drugging tongue, he traced a strange and sinuous symbol there.
A peculiar warmth blossomed where he'd licked her. It drifted down her arms, across her chest, infused her body and soul. Her nipples tightened. Her body liquefied. A hot rush of arousal seeped from her womb. Her clitoris throbbed and a scorching hunger growled and snapped like a long-caged beast.
She wanted him.
She wanted him like she had never wanted a man before. Savagely.
She ached to fist her fingers in his hair and drag him down on top of her. To take his lips with her own. Suck on his tongue. Consume him. Grind against that magnificent cock until he howled with need. Until he took her. Fucked her. Impaled her.
Her mind reeled with pleasure and passion…and confusion.
What was this?
This was not like her.
Not like her at all.
Hadn't Carter told her repeatedly that she was frigid?
She had never wanted like this. Ached like this. Needed like this.
"What are you doing to me?" Even to her own ears, the cry was laced with pleasure, desire, delirium. She placed her palm flat on his chest to push him away but at that touch, passion swelled—the passion in her and the passion in him, tangling, twining. His skin was smooth but his hard muscles bunched beneath her touch.
He threw his head back and groaned in ecstasy. Or perhaps agony. Or both.
"I can't. I need… I want to…" He hissed through his teeth. "But I cannot wait. I cannot."
Easing her down onto the cushions, he covered her. The sensation of his hot, sweat-dampened skin against hers sent a shock wave through her. He nudged her legs apart. Neared. She writhed beneath him, eager, wanton, lost in wonder. Ravenous for him. Impatient.
He did not make her wait.
Get it now!
Free on Kindle Unlimited
Enter to win the Wicked Enchantment tiara here:
About Sabrina York:
Her Royal Hotness, Sabrina York, is the New York Times and USA Today Bestselling author of hot, humorous stories for smart and sexy readers. Her titles range from sweet & snarky to scorching romance. Visit her webpage at www.sabrinayork.com to check out her books, excerpts and contests. Newsletter: http://eepurl.com/bj8tKb.
Bookshelf! http://sabrinayork.com/books/
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Website: http://sabrinayork.com/
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Zip-lines, collapsing ice bridges and auto-turrets are all coming to Call of Duty: Black Ops multiplayer next month, if you game on an Xbox 360.
Due out on the Xbox 360 on February 1, and one day the PlayStation 3 and PC, the First Strike map pack will include four new mulitplayer maps and a zombie map for 1200 Microsoft Points, or about $US15.
The maps will each offer a unique twist to the always addictive gameplay of Black Ops.
Kowloon, inspired by the Hong Kong mission found in the game's singleplayer campaign, was rebuilt specifically for multiplayer matches, according to Treyarch. The game is packed with layers of rooftops and hiding spots and includes a zip-line that will let you quickly sweep between spots on the map, but do so without access to your weapons.
Discovery is a map set in an antarctic research station, a station that happens to be evenly divided by a deep chasm. Fortunately there's a single ice bridge connecting the sides, a bridge that can be collapsed.
Berlin Wall has you playing in East and West Berlin and includes a No Man's Land loaded with auto turrets.
Finally, Stadium is a close quarters map with plenty of places to run around and hide in.
There don't appear to be any details about the new zombie map, at least not yet.
The developers say the pack is coming to the Xbox 360 first, but don't get into when or if the pack will be hitting the PC and PlayStation 3.


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Maybe you're a college student looking to rent your first apartment; or a downsizing homeowner reentering the rental market for the first time in decades. Whatever your situation, there are many precautions you should take before renting any property. The last thing you want is to be saddled with a 12-month lease you can't afford or to be stuck in a neighborhood you've come to detest.
As one who's been there, let me share a few tips for renting a home:
Before you even start looking, know how much you can afford to spend. Housing is the biggest monthly expense for most people so if you miscalculate what rent is affordable, your budget will suffer from the get-go. Besides rent, don't forget such additional expenses as a security deposit, utilities, cable/satellite, Internet access, renters insurance, parking and laundry facilities and one-time move-in expenses like window treatments, appliances or rugs.
Scope out the neighborhood. Determine how safe you feel walking around, especially if you'll be parking on the street. Come back to see if the neighborhood's character changes at night or on the weekend. Also note the proximity to parks, schools, grocery stores, public transportation and busy commuter routes.
Thoroughly inspect each potential rental:
Consider total useable space – sometimes a smaller unit with a well-designed floor plan is more desirable than a larger space with a poor layout.Use a tape measure to measure each room to determine whether your furniture will fit. Ensure there's sufficient closet, cupboard and storage space.Look for safety features like deadbolts and peepholes on exterior doors, well-lit corridors, stairwells and parking structures, smoke detectors, fire extinguishers and bars or other security features on first-floor windows.In multi-unit buildings, note the condition of common areas – that's a clue how attentive the owner/manager is regarding upkeep.Note the condition of appliances, plumbing fixtures, floors/carpeting, electrical outlets and switches, light fixtures, walls and windows. If you spot damaged or worn items, ask whether they'll be replaced. If not, make sure they're noted in the rental agreement.Check the water pressure and hot water quality.Check seals around doors, windows and vents; if leaky, they can boost utility bills.Look for evidence of previous water leaks and mold.Check for soundproofing, especially if there are adjoining apartments.
Once you find a suitable place, read the rental agreement carefully. Don't hesitate to ask a lawyer or more experienced friend to review it. If not spelled out in the lease you may want to ask the landlord:
How much is the security deposit and what are the requirements for getting a full refund?How are rent increases determined?What happens after the lease term ends? Often, it'll convert to a month-to-month rental agreement where you can leave anytime with proper notice (usually 30 days).How many tenants are allowed?What are building policies for things like houseguests, noise curfews, maintenance and repairs, pest control, smoking, lost keys and pets?Can you sublet the unit before your lease expires?
And finally, be aware that many landlords check credit reports of potential tenants. Before you start looking, check your own credit report so there are no surprises. You can order one free report per year from each of the three major credit bureaus – Equifax, Experian and TransUnion. (Order through www.annualcreditreport.com; otherwise you'll pay a small fee.)
Alderman directs Visa's financial education programs. To participate in a free, online Financial Literacy and Education Summit on April 17, 2013, go to www.practicalmoneyskills.com/summit2013.


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Join us in welcoming tax groups to Zoho Books and Zoho Invoice. Tax groups will revive the way you work with your taxes.
there's a need to use more than a single tax to your line items, you
have the option to group those taxes into a tax group and associate
that tax group to the line items, instead of the individual taxes. For
example: In the US state of Alabama, a federal tax, a state tax and a local tax are applicable. For ease of use, the three taxes could be grouped together into a tax group named "Alabama Taxes". While invoicing customers in Alabama, this tax group would be used in place of three separate taxes.
In the example above, if the Federal tax is 15%, the state tax is 5.6% and the local tax is 3.5%, the tax group "Alabama Taxes" would impose a 24.1% tax on a line item. Besides this, you could also mark one of the taxes in the tax group as a "compound tax".
Here are some FAQ which we presume would help you get started with using tax groups.
What if you use only one tax?
If you deal
with just a single tax, you can apply the tax directly to your line
items. Things change only for those who deal with more than a single
Why tax groups?
To make your invoicing simpler and to avoid any errors
while associating taxes. Earlier you'd have selected from two
drop-downs a tax 1 and a tax2. Now, you'll have one drop down to select
from. Your tax selection could either be an individual tax or a tax group.
Here in our example, though the effective tax rate is 24.1%, on the invoice you'd see a clear break up of each of those taxes.
How easy is it to set up tax groups?
Very easy, we would say. We've provided an interactive wizard within your account, to help you set up tax groups. This
wizard will show you the combination of taxes that you've used in your
invoices. You can name and create a tax group out of each of those
combination. Now that's
more than what you bargained for, right?
Wait no more, head straight to your Zoho Invoice or Zoho Books account and set up your tax groups.
If you haven't been following us on twitter it's high time you did because we've been tweeting some all our updates there by the day.


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Mind Space takes your privacy seriously.
Because we gather certain types of information about you, we want you to understand the terms and conditions surrounding the collection and use of that information. This privacy statement discloses the types of information we gather and how we use it.
The information gathered in these pages is used only for internal use by our Customer Care department to contact you or so we can create a project plan and proposal requested. We do not share nor sell your information to anyone. In some cases if we need to provide your contact information to our sister companies or internet marketing partners, we will ask our clients before.
We reserve the right, at any time and without notice, to add to, change, update or modify this Privacy Policy, simply by posting such changes, updates or modifications on the site. Any such changes, updates or modifications will be effective immediately upon posting on the site.


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Revelations from the Ruins
by Don Landis
A "behind-the-scenes" look at the history of what ancient people did, as well as compelling questions and answers about why they did it!
"Gobekli Tepe is ancient ambiguity at its best! Mostly unknowns and fascinating questions, the people who constructed this site left a puzzling legacy in the semi-deserts of Turkey. For years, researchers tried to uncover the mysteries of this site and now what lies buried has been revealed: 20 megalithic stonewalled rings.…When we operate under the biblical presupposition that man was created in the image of God, highly intelligent and creative, around 6,000 years ago, sites like Gobekli Tepe are not shocking to find." - The Secrets of Ancient Man
- More details about the most advanced ancient technology we've ever seen, including Roman nanotechnology
- Identify the counterfeit religion of Babel mirrored in every pagan religion through time
- Why the Tower of Babel incident was about a rebellion that has continued throughout history into the present day!
Knowledge. Wisdom. Understanding. Mankind yearns for these. We find ourselves enthralled with secrets, mysteries, and riddles. Man is seduced by the unknown and enticed by the offer of revelation. Perhaps this is why we pursue science so passionately and we seek desperately to unearth the remnants of our ancestors. We have this innate impression that there is something we don't know, something important that we must discover.
The Ancient Man research team of Jackson Hole Bible College has been hard at work over the past two years since publishing their first book, The Genius of Ancient Man. Dedicated to bringing you more of the fascinating details, commentary, and the Bible affirming truths you loved about ancient man, the team now invites you to think critically about both history and the forces at work in our world today.


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Paying Final Respects with Dignity
At Lee's Funeral Homes & Crematory we arrange different types of funerals to meet individual needs. The main focus should always be on the wishes of the deceased. If the deceased did not express any clear wish while he or she was alive, we recommend that the relatives and other loved ones ask themselves the following questions when choosing the type of funeral:
What type of funeral would fit the life and personality of the deceased?
What effect will it have on how the loved ones will deal with their grief and their memories of the deceased?
We will meet with you personally to discuss these concerns.
On the following pages you will find more detailed information about the individual types of funerals:
I'm a title. To update me, go to the Data Manager.
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Participating Organization(s) |
National Institutes of Health (NIH) |
National Institute of Mental Health (NIMH) |
Funding Opportunity Title |
Limited Competition: National NeuroAIDS Tissue Consortium (NNTC) Clinical Sites (U24) |
Activity Code |
U24 Resource-Related Research Projects Cooperative Agreements |
Announcement Type |
New |
Related Notices |
Funding Opportunity Announcement (FOA) Number |
Companion Funding Opportunity |
RFA-MH-13-071, U24 Resource-Related Research Project - Cooperative Agreement |
Only one application per institution is allowed, as defined in Section III. 3. Additional Information on Eligibility. |
Catalog of Federal Domestic Assistance (CFDA) Number(s) |
93.242, 93.853 |
Funding Opportunity Purpose |
This limited competition Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disease and Stroke (NINDS) solicits applications to continue the activities of the National NeuroAIDS Tissue Consortium (NNTC) Clinical Sites as previously funded under RFA-MH-08-021. The NNTC Clinical Sites collect neuromedical and neuropsychiatric data from late stage, HIV-infected subjects who have indicated a willingness to participate in organ donation. The NNTC Clinical Sites perform clinical assessments, collect brain and neurological tissues and fluids, perform neuropathological diagnosis and laboratory assessments and transfer select data generated from these activities to the NNTC central database which is maintained by the Data Coordinating Center (DCC). The mission of the NNTC is to maintain a research resource that supports studies on the pathophysiology of nervous system complications of HIV infection in the current era of anti-retroviral therapy. The Clinical Sites work cooperatively with the DCC to provide the clinical data and specimen resources to research investigators. Competitive applications for the NNTC DCC are being sought under a separate but related companion FOA (RFA-MH-13-071). |
Posted Date |
July 5, 2012 |
Letter of Intent Due Date |
August 4, 2012 |
Application Due Date(s) |
Not Applicable. |
AIDS Application Due Date(s) |
September 4, 2012 |
Scientific Merit Review |
Advisory Council Review |
January 2013 |
Earliest Start Date(s) |
April 2013 |
Expiration Date |
September 5, 2012 |
Due Dates for E.O. 12372 |
Not Applicable |
Required Application Instructions
It is critical that applicants follow the instructions in the PHS398 Application Guide except where instructed to do otherwise (in this FOA or in a Notice from the NIH Guide for Grants and Contracts). Conformance to all requirements (both in the Application Guide and the FOA) is required and strictly enforced. While some links are provided, applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV. When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review.
Part 1. Overview Information
Part 2. Full Text of Announcement
Section I. Funding Opportunity Description
Section II. Award Information
Section III. Eligibility Information
Section IV. Application and Submission
Section V. Application Review Information
Section VI. Award Administration Information
Section VII. Agency Contacts
Section VIII. Other Information
This funding opportunity follows RFA-MH-08-021 and RFA-MH-08-020 issued jointly by NIMH and NINDS, and aims to continue the NNTC as a resource for investigators interested in conducting NeuroAIDS research to identify the neuropathogenic mechanisms involved in HIV disease of the central and peripheral nervous systems (CNS and PNS, respectively).
The NNTC has served as a unique resource to NeuroAIDS investigators interested in conducting research in HIV disease of the CNS and PNS since 1998. The four current NNTC Clinical Sites and the Data Coordinating Center, (DCC), work cooperatively to provide research investigators with clinically annotated data sets that have been obtained during life, and associated post mortem brain tissue and fluids. This research resource is critical given the investigators need for high quality CNS tissue that is inaccessible to biopsy during life. The Clinical Sites, in collaboration with the DCC, comprise the NNTC. This Consortium has been credited as being instrumental in the research findings of more than 170 publications, and for having compiled an inventory of clinical datasets and specimens, all of which are made available as a research resource including; brain tissue, thousands of plasma and CSF specimens, and additional organs and tissues of interest.
HIV-infected subjects who have advanced disease are enrolled in the NNTC cohort, yet with improvements in disease management and anti-retroviral therapy, survival frequently exceeds expectations, thus the accrual of brain/tissue specimens has been slower than originally expected. The consortium also collects tissue and data from HIV negative individuals who wish to donate. The cohort currently consists of 604 HIV-infected subjects who are evaluated clinically at 6 month intervals. Evaluations are tiered and range from a full clinical assessment to a telephone assessment depending on the clinical status of the subject. Data and biological specimens are obtained using protocols that have been standardized and quality controlled across the consortium. Continuation of the data and specimen collection at the existing NNTC Clinical Sites is critical given that depletion of clinical specimens in high demand has occurred at a time when expanded studies of the mechanisms involved in the manifestation of HIV-associated CNS and PNS diseases is needed.
The key objective for this FOA is to pursue the continued operations of the NNTC Clinical Sites. The NNTC Clinical Sites will continue to collect CNS and PNS tissue and associated clinical data that will be made available to scientific investigators. Included in this goal is the need to incorporate recruitment strategies, based on current data and state of the science, and to selectively enhance the composition of the NNTC cohort. The Clinical Site recruitment strategies should take into consideration the resource needs of investigators engaged in NeuroAIDS research.
The secondary goal of this FOA is to ensure that all data from clinical assessments, pathology, and laboratory tests of clinical specimens performed at the NNTC Clinical Sites are rapidly deposited into the NNTC database to make them available to the research community. The DCC is responsible for the central management of data and will serve as the data repository for the NNTC Clinical Sites. The NNTC Clinical Sites should also ensure that the DCC has an up-to-date inventory of all tissue and fluid specimens collected and housed at the sites. In keeping with this goal, the Clinical Sites are also encouraged to collaborate with the DCC post award to enable deposition of all past clinical data, which has been collected at each site since 1998, into the NNTC central database. These data shall be made available to all qualified investigators via the DCC. Include a description of how the site will ensure quality control and confirmation for delivery of clinical data sets to the DCC.
The tertiary goals of this FOA include the use of the following common, standardized approaches: clinical assessment measures and methods among the NNTC Clinical Sites, a database system to exchange clinical data across NNTC Clinical Sites and with research investigators, and ensuring comparable quality assurance of data across sites. Such a standardized, high quality repository of NeuroAIDS data will enable multidisciplinary query capabilities and tools to accelerate discovery research for HIV-associated CNS and PNS diseases.
Recruitment strategies, which will be used to selectively enhance the continued recruitment of HIV-infected subjects into the NNTC cohort, should be responsive to the research needs of investigators. Investigator needs for research resources may be identified and informed by the scope of prior requests from investigators for NNTC resources and the state of the science. This FOA encourages developing recruitment strategies to enhance the NNTC cohort to help address the following emerging research areas in the NeuroAIDS field: a) eradication of HIV from persistent CNS reservoirs; b) pathogenic mechanism of HIV-associated neurocognitive disorders (HAND) in the setting of long term HAART; and c) HIV and aging.
Funding Instrument |
Cooperative Agreement |
Application Types Allowed |
New The OER Glossary and the PHS398 Application Guide provide details on these application types. |
Funds Available and Anticipated Number of Awards |
NIMH and NINDS intend to commit approximately $3.1 million in FY 2013 to fund 4 awards, including the four current NNTC clinical sites. |
Award Budget |
Although the financial plans of NIMH and NINDS provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds. Funding beyond the first year will be contingent upon satisfactory progress during the preceding years and availability of funds. The application budget for each NNTC Clinical Site is capped at $775,000 per year direct cost. |
Award Project Period |
The total project period for an application submitted in response to this FOA may not exceed five years. |
NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made in response to this FOA.
As this FOA is a limited competition opportunity, only the institutions that are the principal employers of the PD(s)/PI(s) of the National NeuroAIDS Tissue Consortium are eligible to apply in response to this FOA.
Non-domestic (non-U.S.) Entities (Foreign Institutions) are
not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH
Grants Policy Statement, are not allowed.
Applicant organizations must complete the following registrations as described in the PHS398 Application Guide to be eligible to apply for or receive an award. Applicants must have a valid Dun and Bradstreet Universal Numbering System (DUNS) number in order to begin each of the following registrations.
All Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) must also work with their institutional officials to register with the eRA Commons or ensure their existing eRA Commons account is affiliated with the eRA Commons account of the applicant organization.
All registrations must be completed by the application due date. Applicant organizations are strongly encouraged to start the registration process at least4-6 weeks prior to the application due date.
Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
For institutions/organizations proposing multiple PD(s)/PI(s), visit the Multiple Program Director(s)/Principal Investigator(s) Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the PHS398 Application Guide.
This FOA does not require cost sharing as defined in the NIH Grants Policy Statement.
Only one application per institution (normally identified by having a unique DUNS number or NIH IPF) is allowed.
NIH will not accept any application in response to this FOA that is essentially the same as one currently pending initial peer review unless the applicant withdraws the pending application.
Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 Application Guide.
It is critical that applicants follow the instructions in the PHS398 Application Guide, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
By the date listed in Part 1. Overview Information, prospective applicants are asked to submit a letter of intent that includes the following information:
The letter of intent should be sent to:
Dianne Rausch, Ph.D.
Division of AIDS Research
National Institute of Mental Health (NIMH)
6001 Executive Boulevard, Room 6105, MSC 9616
Rockville, MD 20892-9616
Telephone: 301-443-6100
Email: firstname.lastname@example.com
Applications must be prepared using the PHS 398 research
grant application forms and instructions for preparing a research grant
application. Submit a signed, typewritten original of the application,
including the checklist, and three signed photocopies in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)
At the time of submission, two additional paper copies of
the application and all copies of the Appendix files must be sent to:
Jean Noronha, Ph.D.
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6154, MSC 9609
Bethesda, MD 20892-9609
Telephone: 301-443-3367
Email: firstname.lastname@example.com
All page limitations described in the PHS398 Application Guide must be followed, with the following requirements:
The following section supplements the instructions found in the PHS Form 398 for preparing the grant application (U24). Additional instructions are required because the PH398 application Form 398 is designed primarily for the traditional individual, free-standing research project grant (R01) application and several sections have to be modified and expanded so that the form can be used to provide the information needed for a multi-component resource grant application.
Annual Meetings
The PD(s)/PI(s) of the Clinical Sites are expected to attend an annual meeting of the NNTC Steering Committee in the Washington D.C. area, or another agreed upon locality. The meeting will also be planned and attended by the PD(s)/PI(s) of the DCC and any delegates of the DCC PD(s)/PI(s). Applicants to this FOA will include travel to the annual meeting in their proposed budget, which should include travel for themselves and a Scientific Advisor (SA). (See Section VI.2. Cooperative Agreement Terms and Conditions of Award).
All instructions in the PHS398 Application Guide must be followed, with the following additional instructions:
Specific Aims (No more than 1 page.)
Each Clinical Site should articulate a plan for continuing resource operations including patient assessments, tissue collections, integration with the DCC, and novel recruitment strategies for enhancement of the NNTC cohort to meet the emerging needs of investigators engaged in NeuroAIDS research.
Research Strategy (No more than 12 pages.)
Responsive applications will address each of the following components (Page numbers indicated below are provided only as guidelines.):
1. NNTC Overview - 1-4 pages
2. Clinical Site Functions and Operating Procedures - 1-6 pages
3. Clinical Site Collaboration with the DCC 1-3 pages
1. NNTC Overview
Each Clinical Site application will provide background information regarding the overall NNTC approach to providing clinically annotated specimens and data to research investigators.
In addition, each site should include their progress in meeting their targeted enrollment and recruitment goals for the prior year, provide the number of annual autopsies collected by the site and identify whether they were conducted as part of the NNTC clinical protocol or outside of the NNTC clinical protocol. Each site should also include accomplishments from the previous award period.
2. Clinical Site Functions and Operating Procedures
Applicants should provide the following details:
3. Clinical Site Collaboration with the DCC
To fully integrate the DCC into the Consortium and encourage capabilities for a federated repository of NeuroAIDS data and specimens, applications are expected to address the following:
Resource Sharing Plan
Individuals are required to comply with the instructions for the Resource Sharing Plans (Data Sharing Plan, Sharing Model Organisms, and Genome Wide Association Studies (GWAS)) as provided in the PHS398 Application Guide, with the following modifications:
It is expected that applications will include information on the following aspects of data coordination, standardization, and sharing:
Do not use the Appendix to circumvent page limits. Follow all instructions for the Appendix (please note all format requirements) as described in the PHS398 Application Guide.
Part I. Overview Information contains information about Key Dates.
Information on the process of receipt and determining if
your application is considered on-time is described in detail in the PHS398
Application Guide.
Applicants may track the status of the application in the eRA Commons, NIH's electronic system for grants
This initiative is not subject to intergovernmental review.
All NIH awards are subject to the terms and conditions, cost
principles, and other considerations described in the NIH Grants
Policy Statement.
Pre-award costs are allowable only as described in the NIH
Grants Policy Statement.
Applications must be received on or before the due dates in Part I. Overview Information. If an application is received after that date, it will not be reviewed.
Upon receipt, applications will be evaluated for completeness by the Center for Scientific Review and responsiveness by components of participating organizations, NIH. Applications that are incomplete and/or nonresponsive will not be reviewed.
NIMH will hold a pre-application teleconference on Tuesday July 17, 2012 from 11:00am - 12:00pm (EST) to which all prospective applicants are invited. This is a technical assistance teleconference conducted by NIMH staff involved in managing this program to explain the goals and objectives of this initiative and answer questions from the attendees. Participating in the teleconference is neither required nor necessary for a successful application. It is intended to be an opportunity to clarify the objectives of the initiative. Potential applicants are encouraged to submit their questions or comments to firstname.lastname@example.com in advance of the call. Applicants interested in participating in the technical assistance call should send a message to the mailbox above to obtain a dial-in number. A set of Questions and Answers from the teleconference will be posted after the session on a site-to-be-determined and announced.
Applicants are required to follow the instructions for post-submission materials, as described in NOT-OD-10-115.
Only the review criteria described below will be considered
in the review process. As part of the NIH mission,
all applications submitted to the NIH in support of biomedical and behavioral
research are evaluated for scientific and technical merit through the NIH peer
review system.
Reviewers will provide an overall impact/priority score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved, in consideration of the following review criteria and additional review criteria (as applicable for the project proposed).
Reviewers will consider each of the review criteria below in the determination of scientific merit, and give a separate score for each. An application does not need to be strong in all categories to be judged likely to have major scientific impact. For example, a project that by its nature is not innovative may be essential to advance a field.
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? Has the site successfully recruited and retained sufficient numbers of participants and served as a research resource for NNTC data and specimens?
Are the PD(s)/PI(s), collaborators, and other researchers well suited to the project? If Early Stage Investigators or New Investigators, or in the early stages of independent careers, do they have appropriate experience and training? If established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-PD(s)/PI(s), do the investigators have complementary and integrated expertise; are their leadership approach, governance and organizational structure appropriate for the project? Are there key personnel in place to conduct NNTC Clinical Site operations ranging from clinical exams and tissue banking to computer management and general study design and analyses?
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Do the investigators present innovative recruitment strategies for enhancement of the NNTC cohort to fulfill the resource needs of investigators engaged in NeuroAIDS research? Are the site clinical, laboratory, and banking plans innovative?
Are the overall strategy, methodology, and analyses
well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented?
If the project is in the early stages of development, will the strategy
establish feasibility and will particularly risky aspects be managed? Has
the site budgeted sufficient time to ensure appropriate oversight of the NNTC
If the project involves clinical research, are the plans for 1) protection of
human subjects from research risks, and 2) inclusion of minorities and members
of both sexes/genders, as well as the inclusion of children, justified in terms
of the scientific goals and research strategy proposed? Are the recruitment strategies for the NNTC cohort feasible given the size and make-up of the
cohort? Are the clinical plans for selecting and maintaining the cohort and
obtaining data and specimens financially feasible and well coordinated with
other Clinical Sites? Does the site propose an organizational structure that
facilitates collaboration with the Data Coordinating Center, NNTC Clinical
Sites, and research investigators?
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements? Does the environment foster collaboration with other HIV/AIDS research groups through proximity to patient populations, established interactions with community advocacy groups, or access to other sources of funding in areas of science related to the aims of the NNTC? Are the infrastructure, available resources, study populations, and institutional collaborations in place and adequate to support the overall objectives of the NNTC?
As applicable for the project proposed, reviewers will evaluate the following additional items while determining scientific and technical merit, and in providing an overall impact/priority score, but will not give separate scores for these items.
Protections for Human Subjects
For research that involves human subjects but does
not involve one of the six categories of research that are exempt under 45 CFR
Part 46, the committee will evaluate the justification for involvement of human
subjects and the proposed protections from research risk relating to their
participation according to the following five review criteria: 1) risk to
subjects, 2) adequacy of protection against risks, 3) potential benefits to the
subjects and others, 4) importance of the knowledge to be gained, and 5) data
and safety monitoring for clinical trials.
For research that involves human subjects and meets the criteria for one or
more of the six categories of research that are exempt under 45 CFR Part 46,
the committee will evaluate: 1) the justification for the exemption, 2) human
subjects involvement and characteristics, and 3) sources of materials. For
additional information on review of the Human Subjects section, please refer to
the Human
Subjects Protection and Inclusion Guidelines.
Inclusion of Women, Minorities, and Children
When the proposed project involves clinical research, the committee will evaluate the proposed plans for inclusion of minorities and members of both genders, as well as the inclusion of children. For additional information on review of the Inclusion section, please refer to the Human Subjects Protection and Inclusion Guidelines.
Vertebrate Animals
The committee will evaluate the involvement of live vertebrate animals as part of the scientific assessment according to the following five points: 1) proposed use of the animals, and species, strains, ages, sex, and numbers to be used; 2) justifications for the use of animals and for the appropriateness of the species and numbers proposed; 3) adequacy of veterinary care; 4) procedures for limiting discomfort, distress, pain and injury to that which is unavoidable in the conduct of scientifically sound research including the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices; and 5) methods of euthanasia and reason for selection if not consistent with the AVMA Guidelines on Euthanasia. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animal Section.
Reviewers will assess whether materials or procedures proposed are potentially hazardous to research personnel and/or the environment, and if needed, determine whether adequate protection is proposed.
Not Applicable.
Not Applicable.
Not Applicable.
As applicable for the project proposed, reviewers will consider each of the following items, but will not give scores for these items, and should not consider them in providing an overall impact/priority score.
Applications from Foreign Organizations
Not Applicable.
Select Agent Research
Reviewers will assess the information provided in this section of the application, including 1) the Select Agent(s) to be used in the proposed research, 2) the registration status of all entities where Select Agent(s) will be used, 3) the procedures that will be used to monitor possession use and transfer of Select Agent(s), and 4) plans for appropriate biosafety, biocontainment, and security of the Select Agent(s).
Resource Sharing Plans
Reviewers will comment on whether the following Resource Sharing Plans, or the rationale for not sharing the following types of resources, are reasonable: 1) Data Sharing Plan; 2) Sharing Model Organisms; 3) Genome Wide Association Studies (GWAS); and 4) Plans for interactions with other relevant ongoing studies of NeuroAIDS to maximize investments and further standardization and sharing across projects.
Budget and Period of Support
Reviewers will consider whether the budget and the requested period of support are fully justified and reasonable in relation to the proposed research.
Applications will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), convened by the participating ICs, in accordance with NIH peer review policy and procedures, using the stated review criteria. Review assignments will be shown in the eRA Commons.
As part of the scientific peer review, all applications:
Appeals of initial peer review will not be accepted for applications submitted response to this FOA.
Applications will be assigned on the basis of established PHS referral guidelines to the appropriate NIH Institute or Center and will compete for available funds with all other recommended applications submitted in response to this FOA. Following initial peer review, recommended applications will receive a second level of review by the National Advisory Mental Health Council and the National Advisory Neurological Disorders and Stroke Council. The following will be considered in making funding decisions:
After the peer review of the application is completed, the PD(s)/PI(s) will be able to access his or her Summary Statement (written critique) via the eRA Commons.
Information regarding the disposition of applications is available in the NIH Grants Policy Statement.
If the application is under consideration for funding, NIH
will request "just-in-time" information from the applicant as
described in the NIH
Grants Policy Statement.
A formal notification in the form of a Notice of Award (NoA) will be provided
to the applicant organization for successful applications. The NoA signed by
the grants management officer is the authorizing document and will be sent via
email to the grantee's business official.
Awardees must comply with any funding restrictions described in Section IV.5. Funding Restrictions. Selection
of an application for award is not an authorization to begin performance. Any
costs incurred before receipt of the NoA are at the recipient's risk. These
costs may be reimbursed only to the extent considered allowable pre-award costs.
Any application awarded in response to this FOA will be subject to the DUNS,
CCR Registration, and Transparency Act requirements as noted on the Award
Conditions and Information for NIH Grants website.
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General and Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities. More information is provided at Award Conditions and Information for NIH Grants.
The following special terms of award are in addition to, and
not in lieu of, otherwise applicable U.S. Office of Management and Budget (OMB)
administrative guidelines, U.S. Department of Health and Human Services (DHHS)
grant administration regulations at 45 CFR Parts 74 and 92 (Part 92 is
applicable when State and local Governments are eligible to apply), and other
HHS, PHS, and NIH grant administration policies.
The administrative and funding instrument used for this program will be the
cooperative agreement, an "assistance" mechanism (rather than an
"acquisition" mechanism), in which substantial NIH programmatic
involvement with the awardees is anticipated during the performance of the
activities. Under the cooperative agreement, the NIH purpose is to support and
stimulate the recipients' activities by involvement in and otherwise working
jointly with the award recipients in a partnership role; it is not to assume
direction, prime responsibility, or a dominant role in the activities.
Consistent with this concept, the dominant role and prime responsibility
resides with the awardees for the project as a whole, although specific tasks
and activities may be shared among the awardees and the NIH as defined below.
The NNTC Clinical Site PD(s)/PI(s) have the following primary responsibilities:
NIH staff have substantial programmatic involvement that is above and beyond the normal stewardship role in awards, as described below:
The NIMH will appoint a Project Scientist (PS). Only the NIMH PS will have substantial scientific/programmatic involvement during the conduct of this activity through technical assistance, advice and coordination above and beyond normal program stewardship for grants or cooperative agreements. The NIMH PS will be responsible for:
Areas of Joint Responsibility include:
Members of the NNTC Steering Committee (SC) include the following: NIH Program Officers and NIMH Project Scientist; the PD(s)/PI(s) of each grant award, or a designated representative in the case of a multiple PI award; and one Scientific Advisor (SA) from each clinical site. The Data Coordinating Center PD(s)/PI(s) (DCC PI), or a delegate of the DCC PI, will serve as Chair of the SC (SC Chair). Voting members will consist of each Clinical Site PD(s)/PI(s), the DCC PI or the delegate, the SC Chair (if different from the DCC PI), and the NIMH Project Scientist (NIMH PS). In the case of multiple-PD(s)/PI(s), consensus should be reached among those PD(s)/PI(s) in casting a single vote. Decisions of the steering committee will be accepted by all members. The SC has the following responsibilities:
Access to Data and Specimens
In view of the importance of biological specimens and clinical data, a detailed inventory of the number and types of biological specimens and clinical data should be reported to the DCC by the Clinical Sites. All requests for access to and/or release of NNTC-related specimens and/or data, whether from investigators internal or external to the NNTC, should include a detailed description of the study for which specimens are sought and the number and volume of specimens requested. Such requests should be made in accordance with a standardized NNTC Data and Specimen request form which is provided to the SC for approval or not. Prior to approval and release of specimens and/or data, research plans submitted to the SC will be evaluated to determine appropriate procedures are in place for any additional human or animal work.
Dispute Resolution
Any disagreements that may arise in scientific or programmatic matters (within the scope of the award) between award recipients and the NIH may be brought to Dispute Resolution. A Dispute Resolution Panel composed of three members will be convened. It will have three members: a designee of the Steering Committee chosen without NIH staff voting, one NIH designee, and a third designee with expertise in the relevant area who is chosen by the other two; in the case of individual disagreement, the first member may be chosen by the individual awardee. This special dispute resolution procedure does not alter the awardee's right to appeal an adverse action that is otherwise appealable in accordance with PHS regulation 42 CFR Part 50, Subpart D and DHHS regulation 45 CFR Part 16.
When multiple years are involved, awardees will be required to submit the Non-Competing Continuation Grant Progress Report (PHS 2590) annually and financial statements as required in the NIH Grants Policy Statement.
A final progress report, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the NIH Grants Policy Statement.
The Federal Funding Accountability and Transparency Act of 2006 (Transparency Act), includes a requirement for awardees of Federal grants to report information about first-tier subawards and executive compensation under Federal assistance awards issued in FY2011 or later. All awardees of applicable NIH grants and cooperative agreements are required to report to the Federal Subaward Reporting System (FSRS) available at www.fsrs.gov on all subawards over $25,000. See the NIH Grants Policy Statement for additional information on this reporting requirement.
We encourage inquiries concerning this funding opportunity and welcome the opportunity to answer questions from potential applicants.
GrantsInfo (Questions regarding application instructions and
process, finding NIH grant resources)
Telephone 301-710-0267
Email: firstname.lastname@example.com
eRA Commons Help Desk (Questions regarding eRA Commons
registration, tracking application status, post submission issues)
Phone: 301-402-7469 or 866-504-9552 (Toll Free)
Email: email@example.com
Jeymohan Joseph, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-443-3012
Email: email@example.com
May Wong, Ph.D.
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-1431
Email: firstname.lastname@example.com
David Armstrong, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-443-3534
Email: firstname.lastname@example.com
Rita Sisco
National Institute of Mental Health (NIMH)
Telephone: 301-443-2805
Email: firstname.lastname@example.com
Tijuanna DeCoster
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9531
Email: firstname.lastname@example.com
Recently issued trans-NIH policy notices may affect your application submission. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement.
Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 45 CFR Parts 74 and 92.
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2009 College of Engineering Awards
The recipients of 2009 College of Engineering Awards for Electrical Engineering and Computer Science are:
Peter Chen
Research Excellence Award
Prof. Peter Chen has developed a superb track record in research during his 16-year career at Michigan, and his work has produced both theoretical results that have shaped academic thought and practical advances that have been widely adopted by industry. His recent work has produced virtual machine techniques that provide a fundamentally different view of computer forensics, enabling improved debugging, reliability, and security of systems. He has also made significant recent contributions in the use of memory for permanent storage and in defining the limits of generic recovery. He is an exceptional educator, having mentored several graduate students who have gone on to take top positions in academia and industry, and has created the ENGR 100 section on microprocessors and music.
Brian Gilchrist
Service Excellence Award
Prof. Brian Gilchrist has an impressive record of service to the Electrical and Computer Engineering division, to the department, and to the College of Engineering. He served as interim chair of EECS 2006-2007, and then of Electrical and Computer Engineering 2007-2008. Before this he was Associate Chair of EECS. He has served as faculty co-advisor of the Solar Car team since 2000, cofounded the highly successful Student Space Systems Fabrication Laboratory, and currently chairs the CoE Multidisciplinary Design Initiative. He is devoted to the students of the department, as well as the faculty and staff. All know him to be extremely positive, congenial, and able to maintain excellence in research and teaching while contributing greatly to the success of others.
Anatoly Maksimchuk
Outstanding Research Scientist Award
Dr. Anatoly (Tolya) Maksimchuk has been a leader and key member of the high field research group at the Center for Ultrafast Optical Science (CUOS) for many years. He has made tremendous pioneering contributions to the field of laser-matter interaction at relativistic intensities, and he is continuing to have an enormous impact to the development of high-energy table-top particle accelerators as he pursues experiments on Hercules, the highest-intensity laser in the world. In addition to his work at CUOS, he has been an important leader in high field science area at the Frontiers in Optical Coherent and Ultrafast Science (FOCUS) center. Dr. Maksimchuk is an excellent educator and has mentored several graduate students who are now employed in governmental laboratories, industry and academia.
Kurt Metzger
Thomas M. Sawyer, Jr. Teaching Award
Dr. Kurt Metzger has taught the senior-level major design experience course Digital Signal Processing Design Laboratory (EECS 452) for the past decade. He brings a remarkable level of dedication to this course and to the students that take it, which has a major impact on the students' careers. After the course had been redesigned by Dr. Metzger, it came to have an outstanding reputation among industry recruiters. Some companies even require students to have taken this course. He has kept the course current by integrating the latest hardware and software technology into the labs. He is known for being extremely devoted to the students and how they are learning the material.
Mahta Moghaddam
Education Excellence Award
Prof. Mahta Moghaddam directs a large, highly successful and diverse research group focusing on the development of next generation radar remote sensing systems and techniques, while teaching undergraduate and graduate courses on electromagnetics, radar, and remote sensing. She is known for her ability to explain difficult material and concepts clearly and concisely, while maintaining a friendly and approachable manner even in large undergraduate courses. At the same time, she has revised the graduate curriculum in radar and remote sensing, and brought a high level of mentorship to her graduate students. Students speak extremely highly of her excellent teaching ability combined with patience and cheerfulness, as well as her willingness to encourage them in their work.
Todd Austin, David Blaauw, Scott Mahlke, Trevor Mudge, Marios Papaefthymiou, Dennis Sylvester
Ted Kennedy Family Team Excellence Award
Profs. Austin, Blaauw, Mahlke, Mudge, Papaefthymiou, and Sylvester have collectively brought the University of Michigan into the forefront as a world-class research center in low-power computing. Team members are engaged in research from circuits to architectures that is laying the groundwork for advances in mobile and reduced power computing.
Prof. Austin's research has developed techniques for dynamic verification, which works to increase the degree of speculation in microprocessor designs. This is an aggressive performance optimization that permits execution of instructions before it is known that they are needed by a program.
Prof. Blaauw's research has produced development of a novel error detection and correction mechanism which enables supply voltage to be reduced until the point of first failure and further, trading off the overhead of correcting errors versus energy saved. This led to the development of the Razor microprocessor. He continues to investigate sub-threshold power and error correction techniques.
Prof. Mahlke created the Signal Processing On Demand Architecture (SODA), the first fully programmable architecture that supports 3G wireless baseband processing with only a several hundred milliwatt power budget. Prof. Mahlke is now studying the architectural and algorithmic challenges for 4G wireless.
Prof. Mudge was an early proponent of low power computing and the first at Michigan, in 1998, to pursue research in this area. His interest in the discipline was engaged after observing that the quest for higher clock rates was unsustainable due to excessive power consumption. He has contributed in areas of intelligent energy management, robust computing, and most recently the PicoServer concept of using low-power multicores and 3D stacking as a building block for energy-efficient data centers.
Prof. Papaefthymiou has developed the energy-frugal approach of adiabatic electronics and novel techniques for energy recycling that have yielded chips operating at extremely low power consumption. The potential commercial impact of this technology has prompted him to found Cyclos Semiconductor. He continues to explore circuit-level approaches that hold the promise of order-of-magnitude reductions in the power consumption of GHz-speed microprocessors through energy recycling.
Prof. Sylvester has developed world-record energy efficient microprocessors in collaboration with Prof. Blaauw for use in implantable medical devices and wireless sensor networks. Integrated circuit design techniques that he has developed with Profs. Blaauw and Mudge have led to orders of magnitude reductions in power consumption and point to the possibility of cubic millimeter scale (ie, invisible) computing.


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Infographics are so popular now that there's a very meta infographic… on infographics. Check out this image by Ivan Cash for some statistics on their design and content.
Browse more data visualizations. It's All About the Images [Infographic] http://www.mdgadvertising.com/blog/its-all-about-the-images-infographic/ Some say image is everything, and that's especially true on the Internet where the shift to visual optimization is playing an increasingly important role in the recent phenomenon of photo marketing. In light of their numerous benefits for brands of all kinds, MDG Advertising developed an insightful infographic that illustrates the influence of images on a company's business, branding, search, and social media efforts. For insight on optimizing images for content and commerce, along with advice on image optimization techniques, take a look at the infographic to see why images can help make success a snap. First, the infographic details the power of Pinterest whose popularity has propelled the use of high-quality images in sharable online content. It also explains how Facebook's greater focus on images has led the social media giant to switch to Timeline and acquire photo startup Instagram. Next, the impact of images on articles is examined since content featuring compelling images averages 94 percent more total views than those without. It also illustrates how articles featuring news, political, and sports content appear to benefit the most from relevant images. In regard to press materials, the infographic shows that total online views are directly related to the number of multimedia elements within. A larger number of photos, videos, and other media accompanying press releases result in higher views. Local search is also discovering the positive impact of images, with 60 percent of consumers more inclined to select a business with images in its local listing. This illustrates the strong relationship between image and photo SEO, which businesses can no longer afford to ignore as more and more companies realize the attention-grabbing power of images in local search. The infographic goes on to explain why high-quality images are essential to e-commerce. Clear, detailed images are deemed to be very important by 67 percent of consumers and carry even more weight than the product information, full description, and customer ratings. Finally, the correlation between images and social media is examined and it's no surprise that posts with photos have higher levels of social engagement than other types of posts. Advice on optimizing images for social media is also featured. As MDG's infographic shows, images are the rising stars of the Internet and harnessing the enormous power of image optimization in a company's photo marketing strategy can result in unlimited potential and performance for an image-savvy business. Browse more Business infographics. A market where consumers are the main media. Let's face it; the traditional cell phone is being overtaken by the far more capable smartphone. Equipped with high-speed internet connections and lightning fast processors, these devices have essentially put fully capable, interactive billboards in our pockets for marketers to experiment with. How are advertisers taking advantage of this huge potential, and are consumers paying attention? Below we explore the burgeoning world of mobile marketing. On the heels of Google's "disappointing" earnings announcement last Thursday – they generated a whopping $37.9 billion in revenues in 2011 – we conducted our own analysis to determine the top 10 industries that spent the most money on Google advertising last year. The results are summarized in this Google revenues infographic. When you hear the word 'geek,' an image of a nerd with tapped glasses and a pocket protector instantly comes to mind. This infographic shows the evolution of the geek from super nerd to super chic. These days it's cool to be geeky, whether you're a film geek, tech geek or book geek. While there are still different levels of geekdom – one thing is for certain – geeks rule the world. Browse more data visualizations. |


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Whether you're expecting a child, planning to have one soon or have just become a new parent, you're about to embark on one of the most rewarding journeys that life has to offer. It's also one of the most expensive: an average of $12,500 per year until age 18.1. That's $225,000 per child, and it doesn't include the cost of post-secondary education. Planning for this is one way to be the best parent you can be.
Positioning your child, family and your future for success isn't as daunting as you'd think, but now is the time to do it. Babies are an exhilarating whirlwind, and time moves quickly. Laying a solid financial foundation before or shortly after baby joins your family will empower you as a parent as your child grows. It will also give you the peace of mind to put your focus where it should be: on your family.
Here are some important things to consider as you begin building or revising your financial plan:
Insurance Coverage
If something were to happen to you or your partner, would you be able to handle the financial burdens of being a single parent or losing one income? Having the right insurance in place mitigates this problem. You may already have group coverage from your employer, but insurance needs to evolve as your life and family grow. Many group insurance plans are limited, so find out if you're protected with Disability, Critical Illness and Life insurance. If not, it may be wise to consider the security that an individual policy provides, especially for the primary breadwinner in your family.
Education Savings
The cost of sending a child to university is projected to be $153,000 by the year 2039.2 That's a big number, so it makes good financial sense to start saving as soon as your baby is born. Registered Education Savings Plans (RESPs) are excellent savings tools created just for this purpose. As an added bonus, the Government of Canada offers a 20% match on the first $2,500 you save every year until your child turns 17 with a lifetime maximum benefit of $7,200 per child. The contributions aren't tax-deductible but any gains you make are tax-free.
Prepare A Will
Having an estate plan goes beyond just designating who will inherit your assets. It protects you and your loved ones while you are living and upon your death. Should anything happen to you and your partner, a proper will can also help ensure that your minor children will be cared for by the people you personally choose.
The good news is that you don't have to navigate these situations on your own. Financial advisors can help you put all these foundational pieces in place. They can also guide you with long-term investment plans to help ensure you can provide for your child without compromising your own financial security.
Call us to connect with a financial advisor today.
1. Financial Post: What Does It Cost to Raise a Child in Canada?
2. Canadian Scholarship Trust Plan: Why save with an RESP?
Copyright © 2021 AdvisorNet Communications Inc. All rights reserved. This article is provided for informational purposes only and is based on the perspectives and opinions of the owners and writers only. The information provided is not intended to provide specific financial advice. It is strongly recommended that the reader seek qualified professional advice before making any financial decisions based on anything discussed in this article. This article is not to be copied or republished in any format for any reason without the written permission of the AdvisorNet Communications. The publisher does not guarantee the accuracy of the information and is not liable in any way for any error or omission.


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Internet providers in | 77007
Best Internet Providers in HOUSTON, TX
Discover high-speed connectivity and reliable service with the top Internet providers in City, TX, ensuring seamless online experiences.
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When it comes to choosing an internet provider, you're in for a variety of options that cater to different preferences and needs. When you are searching online for the best internet providers in my area, with so many options, it is easy to feel overwhelmed. But don't worry, we've done the research for you and compiled a list of the top ISPs that provide home internet so you can make an informed decision for your internet connectivity. There are about 9 internet provider services that you can choose from.
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AT&T - DSL and Fixed Wireless available
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At Best Local Internet, you will get the news first of any internet outage near you. You may be tired of having slow speeds and having to search for internet outage near me. Here, you can find the best internet provider options for you according to your area. We cover news about the internet companies providing their internet outage map so customers can check the extent of the disruption and its potential resolution time. We believe that you should get high-speed internet with reliability that you can count on.
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Spectrum is one of the leading internet providers offering an array of features that make it a top choice for many residents. With Spectrum, you'll get access to blazing-fast gigabit speeds, extensive coverage, and even bundle options to maximize your services.
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Home Internet in HOUSTON, TX
T-Mobile 5G is another excellent choice for an internet provider for the residents, offering broad coverage and affordability. They utilize a fixed wireless gateway, granting access to T-Mobile's 5G cellular network for home internet users.
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If you're in search of fast internet speeds, CenturyLink is the provider to consider. They offer plans with the highest Mbps, ensuring you'll never have to worry about a sluggish connection. For those concerned about network coverage, both Spectrum and CenturyLink provide high-speed internet plans.
Don't forget to explore their bundle options for even more attractive monthly deals. We hope this information helps you make an informed decision about the best internet provider for your needs. Remember to enter your zip code to find specific plans and options available in your area. Enjoy your high-speed internet experience!
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GM Gareev Defeats 29 in Blindfold Simul
GM Timur Gareev Defeats 29 Players in Blindfold Simul
PRESS RELEASE: SAINT LOUIS (May 1, 2013) -- It took 10 hours and 39 minutes for Grandmaster Timur Gareev to topple the final king and leave the chess community in Saint Louis dazed and amazed.
On Tuesday, GM Gareev put on a 33-board blindfolded simultaneous exhibition at the Chess Club and Scholastic Center of Saint Louis, scoring 29 wins, four draws and zero losses.
The field, composed entirely of Saint Louis Chess Club members, had an average USCF rating of 1363, and featured of two experts, three class A players (1800-1999) and five class B players (1600-1799).
CCSCSL Executive Director Tony Rich (USCF 2020) was the highest-rated player in the field and one of only four players to draw the blindfolded virtuoso. "It was a truly an amazing experience to witness this remarkable display of concentration and memory," Rich said.
GM Timur Gareev in action during the blindfold simul
GM Gareev is working toward setting a new blindfold simul world record of 64 boards before the end of 2013. The date for the record-breaking simul is tentatively set for December 21 on the Hawaiian island of Oahu. After switching federations from Uzbekistan to the U.S., he will be competing in his first-ever U.S. Championship. He enters the tournament as the No. 2-rated player in the field, second only to GM Gata Kamsky.
The 2013 U.S. Championship and 2013 U.S. Women's Championship will be held simultaneously May 2 through May 13, with the Opening Ceremony taking place the evening of May 2 and the first round of play beginning at 1 p.m. CT on May 3.
Visit www.uschesschamps.com for more info.
Some of Timur's opponents in the simul
The participating players in the simul, their board numbers, and their current USCF ratings are as follows (the * denotes the players that played GM Gareev to a draw):
August Meyer: 987
* Steve Mislich: 1642
Lou Cotton: unr.
Ben Boaz: 1269
Joe Wojcki: 1817
Richard Pack: 1881
Ken West: 1269
Sal Falcone: unr.
* William Little: 1515
Ed Protzel: unr.
Joe Baur: unr.
Tim Baur: 487
Abdul Shakoor: 1176
Diamond Shakoor: 1259
Micah Losee: 1770
Julian Proleiko: 1735
Josh Cardenas: 1334
Jim Smith: 739
Preethi Kembaiyan: 1228
Yizheng He: 1160
Adam Eubanks: 1321
* Justin Hull: 1673
Sathya Anand: 1423
Katie Stujenske: 544
Willy Kane: 1871
Alex Marler: 2012
Adonis "Mark" Reddick: 1548
* Tony Rich: 2020
Sarah Crawford: 476
Jonathan Lake: 581
Richard Pointer: 1594
Brian Jerauld: 1762
Ben Simon: 1437
The average was derived from the 29 rated players with the four unrated players omitted from the calculations. Of the four unrated players, only Ed Protzel is not a current USCF member.
The 2013 U.S. Championship and 2013 U.S. Women's Championship will be held simultaneously May 2 through May 13. This marks the fifth consecutive year that each of these prestigious events will be held in Saint Louis.
The opening ceremony takes place on May 2, and the first round for both events will kick off at 1 p.m. CT on May 3.
Also, fans of the U.S. Chess Championships can participate in Fantasy Chess for free by visiting: http://www.uschesschamps.com/2013-fantasy-chess. The grand prize is round-trip airfare for two from anywhere in the continental U.S., two nights hotel, a private dinner with GM Yasser Seirawan and two private lessons with Seirawan as well.
About The Chess Club and Scholastic Center of Saint Louis
The Chess Club and Scholastic Center of Saint Louis is a non-profit, 501(c)(3) organization that is committed to making chess an important part of our community. In addition to providing a forum for the community to play tournaments and casual games, the club also offers chess improvement classes, beginner lessons and special lectures.
Recognizing the cognitive and behavioral benefits of chess, the Chess Club and Scholastic Center is committed to supporting those chess programs that already exist in area schools while encouraging the development of new in-school and after-school programs. For more information, visit www.saintlouischessclub.org.


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Polar Bottles Session Muck Apex
Small, but mighty, the Breakaway® Session Muck™ is the ideal companion for dusty single track and muddy rides.
Small, but mighty, the Breakaway® Session Muck™ is the ideal companion for dusty single track and muddy rides. Lightweight and squeezable, the Session Muck features a Muckguard™ cap cover that protects the Surge™ valve from whatever the trail dishes up. This unique 15oz size is built to fit any frame size and is compatible in full suspension bike frames that are tight on space.
Full Features:
- Muckguard™ Protects Surge™ Valve from whatever the trail dishes up. Designed for mountain bikers, gravel grinders, and all-weather roadies. Opens and closes with one hand - seals valve when closed.
- The Breakaway Surge valve maximizes flow rate and self-seals to eliminate spills and splatter. It's spill-proof when open, and pushes closed for leak-proof transport.
- Unique 15oz size was designed with mountain biking in mind - built to fit any frame size and/or full suspension bike with limited real estate for bottles
- Polar Bottle is the original, 100% BPA-free insulated water bottle. The updated Breakaway water bottle features a sleek, single-wall design that is light, durable, and compact.
- Our bottles are designed with ultra-light materials and a unique grip groove, so you can hydrate with an easy squeeze.
- The innovative Polar Bottle Surge Cap is two pieces - cap and valve - and easy to clean. Simply twist, pull, and wash. Plus, they're dishwasher safe.
- Polar Bottle insulated water bottles are crafted in Colorado to reduce environmental impact and support local economies. Designed to last, each one of our water bottles comes with a lifetime guarantee.
Part Numbers
Option | UPC | MPN | Store SKU |
White/Charcoal / 15-ounce | 617823004827 | SWM15OZ13 | |
Charcoal/Black / 15-ounce | 617823004834 | SWM15OZ10 | 210000138515 |
Forest Green / 15-ounce | 617823004858 | SWM15OZ15 | |
Navy Blue / 15-ounce | 617823004841 | SWM15OZ14 |