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Why choose Agni Link connector for AutoCAD?
AutoCAD is, no contest, the industry standard for cross-industry design and drafting applications. The Agni Link connector for AutoCAD automates the process of exchanging design information between engineering and manufacturing.
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The Agni Link Benefits
Reduce Design Time by up to 25%
In ETO-intensive manufacturing, anywhere between 5% and 25% of the total engineering is devoted to the transfer of Bills of Materials from engineering to manufacturing. Automating that process translates into dramatic savings… and improved lead time.
Elimination of Costly Errors on Factory Floor
Increased BoM accuracy brings increased product quality, better yield on raw materials… and lower production costs.
Rapid ROI
Agni Link usually pays for itself very quickly. Recovery periods of 180 days or less are not uncommon.
Guaranteed on-Budget Implementation
With Elmo Solutions' fixed fee programs, configuration and deployment are done for a fixed fee, no matter how complex your requirements are. Guaranteed cost… Guaranteed peace of mind!
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Agni Link's unique architecture allows automatic resolution of discrepancies, based on rules over which the customer has complete control. Another way we can maximize engineering time.
No Programming. Ever.
An Agni Link customer has full control over the integration process, thanks to the Agni Link Integration Builder. Add as many mappings as you like, modify or suppress existing mappings. Define data validity by your own rules. Without any programming whatsoever.
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The JumpStart (implementation support) and BigBangBoMs (Data Initialization) Programs greatly enhance the value of the solution by bringing complementary services… for a fixed fee. No surprises!
Up And Running in 30 Days… or Less.
From the kick-off meeting to the final rollout, a typical implementation is normally completed within 20 business days.
Agni Link currently works in English and French. Configuring other languages is a straightforward process, and can be easily done upon request.
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Yes I'm a Trump Girl Deal with it Tumbler
20 oz or 30 oz Yes I'm a Trump Girl Deal with it Tumbler.
Each tumbler is made to order and are hand made with means there may be small imperfections in the cup. Not all tumblers are 100% perfect. Occasionally color may slightly vary from photo. And MAY (5% of the time out of 100) include slight seam line or imperfections but this will not affect the use of the tumbler. We make every possible effort possible to create a flawless piece for you, but we are human, and flaws may be present
This tumbler is double-walled installed and stainless steel. Keeps drinks cold for up to 20 hours and hot drinks hot for up to 8 hours. These tumbler comes with a lid and a straw. To keep colors vibrant do not wash in the dishwasher.

subset: commoncrawl


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Title: Aurora Rose Reynolds'
Happily Ever Alpha Kindle World
Happily Ever Alpha Kindle World
Authors: Various
Genre: Contemporary Romance
Release Date: April 3, 2018
Happily Ever Alpha Kindle World
The Happily
Ever Alpha Kindle world includes 16 authors that will be releasing books based on characters or places in the Until,
Until her and Until him series. Every single author included in the world has
been hand picked by me. I've personally loved their books and writing styles
and hope if you haven't read them before that you will fall in love with them
just like I have.
Some of the
authors have chosen to write about characters or couples that you have met in
the series while others have just referred to a place or person from one of the
Until books. I hope you give every single author a chance.
Every book is a stand-alone; there is no reading order.
Until Arsen – K.L. Donn
Until Avery – Brynne Asher
Until Brandon – Natasha Madison
Until I Saw You – Jordan Marie
Until Kayla – CC Monroe
Until Leo – Rochelle Paige
Until Mallory – Ella Fox
Until More – S. Van Horne
Until Nox – Layla Frost
Until Rayne – Elle Christensen
Until Sunrise – Sarah O'Rourke
Until Susan – CP Smith
Until The Summer – Elle Jefferson
Until We Meet Again – KD Robichaux
Until You – Samantha Lind
Until You're Mine – Jenika Snow
For more details about
the Happily Ever Alpha Kindle World


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The Valencia College Digital Library provides online access to historical photos, student publications from the 1960s to the 1980s, and other documents from our archival collection.
Celebrate Valencia's 50th anniversary with images from Valencia's history. Do you know any of the people, buildings, or events pictured? Please email firstname.lastname@example.com and tell us about it.


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Dr. Bu Abdullah is an Emirati Businessman of par excellence, having his expertise in law and business. He completed his training at military school. In 2005, he embarked with his own company called Bu Abdullah Group of Companies. He is the chairman of Bu Abdullah group and Guinness book of world record holder. He managed to acquire top business professionals from around the globe through his expertise and experience along with the top lawyers that he knew who were competent.
Dr. Abdullah was the first Emirati ever to be invited to the Lok Sabha in India, he visited during the Atal Vajpayee Awards in the year 2019. The doctor has only one mission that he would like to succeed in, more opportunities for growth in local areas of different communities, and do this in every country, he can, around the world. He has helped the economy of the United Arab Emirates grow significantly by his business ventures such as the Bu Abdullah Real Estate Company, or the Bu Abdullah Pro Service and the Wafa Ali Al Hosany Lawyer and Advocate organization. This has led him to support Shri Anurag Maheshwari in his vision, SOCIETY ARRANGEMENTS FOR CULTURE, HUMANITY, MEDITATION AND ENLIGHTENMENT (SACHME) – Hindu Recreational Centre.
The masses have known Shri Anurag Maheshwari to be quite a successful businessman over the years. In the case he does not sound familiar, maybe the projects he has undertaken will. He is the director of business strategy in the United Arab Emirates and is currently posted in the Office of His Highness Sheikh Hamdan Bin Ahmed Al Maktoum (Member of the Royal Family of Dubai) Investment department.He received his education through the Institute of Chartered Accountant of India. He was still a student in the ICAI and only twenty-four years old when he started his own company, which was only the start of a gigantic empire that he has managed to create today. From there he has gone on to become the proud owner of companies across various industries.
Shri Anurag Maheshwari has managed to leave his mark in finance syndication, event management, import and exporting business, he even owns a production house and an SVOD Platform "MOBIFLIX", which aims to make it big on the global scale. He is also the owner of a sports company and his own cricket team plays in the Abu Dhabi T10 league. Not a surprise, but he is also considered to be the best philanthropist in India. Basically, he is the jack of all trades. He has recently started the SACHME – Hindu Recreational Center, a socio-spiritual volunteer driven organization, with the support of Dr. Bu Abdullah, another successful Emirati businessman and the owner of more than two hundred different companies worldwide.
The United Arab Emirates has a noteworthy number of Indian expatriates living there. And although it is not unknown that the Emirates is tolerant to all cultures and races, a place where the people can connect to their cultures, was sadly not present in their vicinity. This is specifically the issue that Shri Anurag Maheshwari with the support of Dr. Bu Abdullah is trying to tackle. SACHME would be the result of a vision that has four different factors in its core, Cultural identities, rituals, mythologies and the values and ethics that tradition teaches us. This is an ingenious approach and vision of the two businessmen towards social development and it can be very much said that this will definitely help in building up a person's character and keep his psyche as hunky-dory as it gets.
SACHME is going to follow the idea of Welfare and Spiritual connection, The Idea of Welfare – the ideology of "Vasudhaiva Kutumbakam, Sarve Bhavantu Sukhinah Sarve Santu Nairaamaya" that nurture and cultivate love and passion in society, which teaches an individual that the outside world is not filled with enemies but friends and tells them that they should do everything they can in their power to make others happy, because it will, in turn, make the individual happy as well. A beautiful approach taken up by two fairly practical minded individuals, SACHME is stirring up quite the hype already and is all set to go, Kudos. It is planned to set up in 5 different locations across the United Arab Emirates and hoping to expand its reach to different parts of the world such as the United States of America, United Kingdom, Thailand, Australia, Malaysia, Singapore as many as they can get to.
Any one who wish to contribute for a good cause can contribute at
Name of organization – SACHME
ICICI Bank A/c. No. – 36361494827
IFSC Code- ICIC0000104
UPI – open.2000183832@icici
Contact Detail:
Company Name: The Broadcast Media
Contact Person: Media Relations
Email: Send Email
Phone No: 8488888801
Country: India
Website Url: https://thebroadcastmedia.com/


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Brandon Sanderson, fantasy's newest master tale spinner, author of the acclaimed debut Elantris, dares to turn a genre on its head by asking a simple question: What if the hero of prophecy fails? What kind of world results when the Dark Lord is in charge? The answer will be found in the Mistborn Trilogy, a saga of surprises and magical martial-arts action that begins in Mistborn.
For a thousand years the ash fell and no flowers bloomed. For a thousand years the Skaa slaved in misery and lived in fear. For a thousand years the Lord Ruler, the "Sliver of Infinity," reigned with absolute power and ultimate terror, divinely invincible. Then, when hope was so long lost that not even its memory remained, a terribly scarred, heart-broken half-Skaa rediscovered it in the depths of the Lord Ruler's most hellish prison. Kelsier "snapped" and found in himself the powers of a Mistborn. A brilliant thief and natural leader, he turned his talents to the ultimate caper, with the Lord Ruler himself as the mark.
Kelsier recruited the underworld's elite, the smartest and most trustworthy allomancers, each of whom shares one of his many powers, and all of whom relish a high-stakes challenge. Only then does he reveal his ultimate dream, not just the greatest heist in history, but the downfall of the divine despot.
But even with the best criminal crew ever assembled, Kel's plan looks more like the ultimate long shot, until luck brings a ragged girl named Vin into his life. Like him, she's a half-Skaa orphan, but she's lived a much harsher life. Vin has learned to expect betrayal from everyone she meets, and gotten it. She will have to learn to trust, if Kel is to help her master powers of which she never dreamed.
Readers of Elantris thought they'd discovered someone special in Brandon Sanderson. Mistborn proves they were right.


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History of the Universe eBook. 398 pages, 300 illustrations only £5.99
In inflationary theory, the Universe started from almost nothing. What do we mean by nothing? We mean a space which is almost empty: a vacuum. But what is a "vacuum"?
The word is widely mis-used. For example, we talk about a "vacuum cleaner". But such a device works by creating low pressure and depends upon atmospheric pressure to move the air. A vacuum cleaner does not really create a true vacuum.
A true vacuum is a space which is completely empty. It has the lowest possible energy.
But, according to inflationary theory, the very young Universe was not like that. Yes, it contained a vacuum, but it was not completely empty: it was not a true vacuum.
The young Universe appeared stable, that is, it seemed to be at the lowest possible energy state, and yet it was not empty. Instead it contained some energy. This state is described as the false vacuum.
Illustration suggesting how a false vacuum may contain some energy
In fact, far from being empty as a true vacuum is, the false vacuum contained a huge amount of energy packed into a very tiny space. The energy density was much higher than anything we see in the Universe today.
Scientists propose that the very young Universe contained something they call "a field", so next we will examine what a field is.
Get this website as an eBook only £5.99


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A Macon, Georgia-born singer/songwriter, Jason Aldean quietly turned into a genuine country superstar in the back half of the 2000s. His parents separated when he was three years old, and he spent his childhood with his mother in Macon through the school year while spending the summers with his father in Homestead, Florida. Early on, he fell under the spell of country music and made his first public appearance as a singer at a VFW hall in Macon when he was 14 years old. Soon he was a regular at area talent contests, and a year later he joined the house band at Nashville South in Macon. Aldean began pursuing a music career on a full-time basis following his graduation from high school and, with his father as a booking agent, was soon gigging in college towns throughout the Southeast and up and down the Eastern Seaboard.
Aldean privately financed an eight-song CD during this period to sell at shows, recording it in Nashville in 1996. Michael Knox spotted Aldean at an Atlanta showcase a year or two later, and signed the singer to a songwriting contract with Warner-Chapell Publishing, which allowed Aldean to move to Nashville in 1998. When a couple of recording deals fell through and his songwriting contract was about to expire, Aldean was on the verge of giving up on the music business when he attracted the attention of the independent label Broken Bow Records, which released his debut album, simply called Jason Aldean, in 2005. Aldean returned to the studio in January 2007 to work on his sophomore release, Relentless. The album, featuring the single "Johnny Cash," hit stores in May of that year.
Wide Open followed in 2009 and its success established Aldean as a major country star. It had three number one singles — "She's Country," "The Truth," and "Big Green Tractor," which crossed over to the pop Top 20 — and "Crazy Town" was nearly as big, peaking at number two. Aldean upped the ante with 2010's My Kinda Party, an album that was even bigger than its predecessor thanks to the number one singles "Don't You Wanna Stay," "Dirt Road Anthem," and "Fly Over States," plus "Tattoos on This Town" and "My Kinda Party," both of which peaked at number two.
All of this raised expectations for Night Train, Aldean's fifth album, which arrived in the fall of 2012. Featuring the hit singles "Take a Little Ride," "Night Train," and "When She Says Baby," Night Train was another number one hit for Aldean. He followed it up in 2014 with Old Boots, New Dirt, which also entered the Billboard Top 200 and country charts at number one, partially due to the momentum of the hit single "Burnin' It Down." Old Boots, New Dirt generated three other Top Ten hits — "Just Gettin' Started," "Tonight Looks Good on You," and "Gonna Know We Were Here" — that kept it on the charts into 2015. The next year, he delivered his seventh studio album, They Don't Know, whose September 2016 release was preceded by the singles "Lights Come On" and "A Little More Summertime."
In October 2017, while Aldean was on-stage performing at the Route 91 Harvest Festival on the Las Vegas Strip, a gunman began firing on the assembled crowd, resulting in the deadly mass shooting that took the lives of many of the singer's fans. Aldean managed to escape unharmed and appeared the following weekend on Saturday Night Live performing a cover of Tom Petty's "I Won't Back Down." In January 2018 he released "You Make It Easy," the lead single from his Rearview Town album. Completed prior to the Vegas tragedy, Rearview Town appeared in April 2018. ~ Steve Leggett


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Big MAGICK - The Oracle Artist's Way — create your own oracle deck
Gorgeous Oracle Deck by My Student, Heather Hoeps!
cathy nichols create your own oracle deck heather hoeps inner compass oracle deck intuitive collage mini oracle deck new oracle deck online oracle deck class oracle deck class
I could not be prouder of Heather Hoeps, one of my Create Your Own Oracle Deck students, for completing and publishing her GORGEOUS new oracle deck called "Inner Compass." The imagery is a stunning mix of vintage designs combined with Heather's heavenly brushwork and eye for composition. This is a deck of mini cards, and they are printed on rich, thick stock that makes them a joy to hold and use. I was thrilled that the first card I pulled was "Success." It feels just perfect. It truly warms my heart to hear how our online class inspired Heather...


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May Day 2013: LA Schedule
Posted 11 years ago on April 30, 2013, 1:07 p.m. EST by OccupyWallSt
los angeles,
may day
Schedule of Events:
12:00pm: Long Beach Revolutionaries : Back in Actions @ Pershing Square
2:00pm: Occupy LA Meet @ Pershing Square
2:30pm: March to Olympic and Figueroa
3:00pm: Join with Occupy Fights Foreclosures to SHUT DOWN Wells Fargo
4:00pm: Join the SCIC march @ Broadway & Olympic to march for FULL legalization for all!
7:30pm OLA General Assembly @ Pershing Square
Neighboring Occupations are also holding their own events this year! For more information, please visit their Facebook pages:
Additional Information:


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or 3 payments of £25.00 with
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Combining our two best selling designs - our custom name and signature name, this subtle, personalised bracelet makes the ultimate, bespoke gift or a special treat to yourself. Add the birthstone of your choice to make it even more meaningful.
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Free for educational use
Old Age and the Burden of Dementia
Year of production - 1983
Duration - 1min 42sec
Tags - ageing, health, identity, interviews, see all tags
On this Page
How to Download the Video Clip
To download a free copy of this Video Clip choose from the options below. These require the free Quicktime Player.
Premium MP4 outsight_pr.mp4 (12.5MB).
Broadband MP4 outsight_bb.mp4 (5.9MB), suitable for iPods and computer downloads.
You can buy this clip on a compilation DVD.
You can buy the program this clip comes from.
Old Age and the Burden of Dementia is an excerpt from the film Out of Sight (15 mins), an episode of the series Ageing in the New Age (7 × 15 mins), produced in 1983.
Out of Sight: The British Medical Journal has described Dementia as the 'sad quiet epidemic'. It is untrue that we lose our minds with age. But in Australia one in four people aged over 81 years has some form of dementia.
Each program in this series deals with one of a number of issues: approaches to retirement; community support systems that foster independence; living on a pension; ways the elderly are still contributing to the community; the position of elders in different cultural traditions; the problem of dementia; and managing financial investments.
Ageing in the New Age: With an ageing population, the world is approaching a crisis and community debate is growing on the issues raised by ageing populations. Each program in this series of seven films deals with one of those issues: approaches to retirement, community support systems that foster independence, living on a pension, ways the elderly are still contributing to the community, the position of elders in different cultural traditions, the problem of dementia and managing financial investments. They are generally optimistic and uplifting programs, full of innovative ideas and inspiration.
Ageing in the New Age was produced by Film Australia with the assistance of AMP Society.
This digital resource can be used to achieve the following outcomes:
P.1 A student demonstrates understanding of the relationships between composer, responder, text and context.
P.6 A student engages with a wide range of texts to develop a considered and informed personal response.
P.7 A student selects appropriate language forms and features, and structures of texts to explore and express ideas and values.
P.8 A student articulates and represents own ideas in critical, interpretive and imaginative texts.
In almost all Westernised societies, life expectancy is increasing. Although women continue to outlive men, many people of both sexes now live well into their eighties or beyond. This increasingly aged population brings with it an increase in the problems associated with old age. One such problem is dementia.
Dementia is the term used to describe the symptoms of a large group of illnesses which cause a progressive decline in mental functioning.
The early symptoms of dementia are subtle and vary for each person and from day-to-day. Symptoms gradually get worse. Common symptoms include:
- Memory problems, especially for recent events (long-term memory usually remains in the early stages).
- Language and speech difficulties.
- Confusion, getting lost.
- Personality changes and behaviour changes.
- Apathy and withdrawal.
- Loss of ability to do familiar tasks.
Although it is more common in older people, people as young as 40 can get Alzheimer's disease, a common form of dementia. One in four people aged over 85 years in Australia has some form of dementia
- Discuss and write responses to the following:
- Define 'dementia' and 'Alzheimer's disease' in your own words then check using a dictionary.
- Give reasons why dementia is so hard on the interviewee.
- Describe what has happened to her husband's mind, his personality, and his identity using examples from the video clip.
- How does she describe her fears and what she does?
- Describe the values and qualities you see in this woman. Consider what she does, her attitudes to her husband, her attitude to her daughters, etc.
- The video clip shows a 'talking head' only.
- List the techniques the filmmaker uses to try to vary the image presented. For example, zooming in to a close up.
- Suggest other things that could have been done to vary the image presented.
- In a 50-word summary write the audience, purpose and message(s) of this video clip
- Australia's society is ageing. The number of dementia sufferers will continue to increase.
- Discuss ways how the ageing and ageing sick and their carers can be helped. Do you think that society 'owes' these people?
- Write a 500-word letter to the editor, media article or speech presenting your point of view on this issue. Remember to include facts and examples.
Literacy Activity: Focus= Viewing / Interpreting
- The woman in this clip cares for her husband who has dementia. What burdens does her job as carer bring? (2 marks)
- Recount the sad but somewhat humorous story about her husband's activity in the garden. What is sad about this situation? What makes the image amusing? (2 marks)
- Why do you think we only have on interview in this clip? (1 mark)
Go to Alzheimers Australia


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We carry the largest stock levels in the industry. For Defense Department Overnights & A.O.G. Orders, they are usually serviced same day with some exceptions. Cut off times are approximate for all types of orders, please read our shipping policies for processing guidelines.


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July 9, 2009
Big banks to stop accepting California IOUs
By Tami Luhby CNNMoney.com senior writer
Residents have fewer places to cash in IOUs after large banks stop redeeming them. SEC warns potential buyers and sellers of possible scams.
NEW YORK (CNNMoney.com) — Californians have fewer places to redeem IOUs issued by the cash-strapped state.
At least three major banks, Wells Fargo (WFC, Fortune 500), JPMorgan Chase (JPM, Fortune 500) and Bank of America (BAC, Fortune 500), stopped accepting the IOUs after Friday.
More than 60 credit unions, however, continue to accept the paper.
State Controller John Chiang started issuing the IOUs on July 2 to conserve cash, while lawmakers and Gov. Arnold Schwarzenegger tussle over closing a $26 billion budget gap. Friday also marked the start of a mandatory third furlough day for most state employees.
The state, the world's eighth largest economy, has issued more than 90,000 IOUs worth nearly $355 million. Also called registered warrants, the IOUs pay an interest rate of 3.75% and can be redeemed on Oct. 2 or earlier if divided state officials reach a budget deal.
Recipients will include state contractors, social service agencies and those owed income tax refunds.
Banks will work with customers on an individual basis to assist them, perhaps offering them home equity lines or short-term loans, said Beth Mills, spokeswoman for the California Bankers Association. But the institutions are also hoping to send a message to Sacramento.
"What's ultimately in the best interest of everyone will be for the state to act quickly and resolve the budget impasse," she said.
Bank of America's decision stems from its experience in 1992, the last time the state issued IOUs amid a financial crisis. The bank, along with Wells Fargo, were among the first to stop accepting the IOUs. A budget was signed about a month later.
"The longer the registered warrants were accepted, the longer it took the legislature to resolve the matter," said Britney Sheehan, a Bank of America spokeswoman. "We do not want our acceptance of registered warrants to deter the state from reaching a budget agreement as soon as possible."
Customers at participating credit unions can continue to redeem the IOUs. The institutions are bracing for a crush of people looking to turn the warrants into cash.
"There are options," said Daniel Penrod, senior industry analyst at the California Credit Union League. "If people look for those options, they'll realize they are not stuck past the July 10 deadline."
IOUs to be regulated
Some people actually want to get their hands on the registered warrants, posting ads on online marketplaces such as Craigslist. Several postings offer to buy the paper for 85 cents on the dollar, while another listing is looking to sell the IOUs for 95 cents.
This practice, however, has heightened fears that desperate IOU holders might be taken advantage of and that counterfeiters might make copies of the warrants.
State Treasurer Bill Lockyer last week said that warrant buyers must obtain a notarized bill of sale from the recipient when purchasing the IOUs. This will help ensure that the person redeeming the IOUs is the legitimate owner, said Bill Dresslar, Lockyer's spokesman.
The Securities and Exchange Commission on Thursday said that the IOUs are securities and are subject to federal anti-fraud provisions. The agency also issued an investor alert warning both buyers and sellers to be careful when trading the warrants.
"If you hold an IOU and wish to sell it prior to maturity you should consider whether you think you are getting a fair price," the alert said. Investors who wish to buy IOUs should also understand who the seller is. If you are buying from a third party, ask if the person is registered to do this business.
The SEC's action has both positive and negative impacts on IOU recipients, experts said.
It should cut down on scams because the warrants would have to be traded through registered brokers, said Joseph Fichera, who heads Saber Partners, a financial consulting firm for governments and corporations. Sellers would have to provide disclosure and make sure they are marketing the products properly.
This, however, would also make it harder to offload the IOUs, which could frustrate recipients in need of cash.
"The SEC is trying to provide some sort of framework for investor protection in the middle of uncharted territory," Fichera said.
© 2007 Cable News Network LP, LLP.


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You are here
News Release
Tuesday, January 20, 2015
NIH researchers tackle thorny side of gene therapy
Pre-clinical studies in mice reveal ways to reduce cancer risk with modified treatment.
National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping their findings may eventually help improve gene therapy for humans. Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, published their research in the Jan. 20, 2015, online issue of the Journal of Clinical Investigation.
"Effective and safe gene therapies have the potential to dramatically reverse diseases that are life-threatening for affected children."
"Effective and safe gene therapies have the potential to dramatically reverse diseases that are life-threatening for affected children," said NHGRI Scientific Director Dan Kastner, M.D., Ph.D. "This study is an important step in developing gene therapies that can be safely used to benefit patients."
Toxic side effects actually are rarely observed by researchers who have designed gene therapies using an adeno-associated virus (AAV) as a vector to deliver the corrected gene to a specific point in the cell's DNA. AAVs are small viruses that infect humans but do not cause disease. A vector is a DNA molecule of AAV used as a vehicle to carry corrected genetic material into a cell. AAV viruses are uniquely suited for gene therapy applications.
But one prior study did find an association between AAV and the occurrence of liver cancer. The present research addresses this problem in gene therapy for an inherited disease in children called methylmalonic acidemia, or MMA.
For 10 years, NHGRI researchers have worked toward a gene therapy to treat MMA. The condition affects as many as 1 in 67,000 children born in the United States. Affected children are unable to properly metabolize certain amino acids consumed in their diet, which can damage a number of organs and lead to kidney failure. MMA patients also suffer from severe metabolic instability, failure to thrive, intellectual and physical disabilities, pancreatitis, anemia, seizures, vision loss and strokes. The most common therapy is a restrictive diet, but doctors must resort to dialysis or kidney or liver transplants when the disease progresses.
In prior MMA gene therapy studies, researchers showed that mice bred to develop the condition could be restored to health by AAV gene therapy injection shortly after birth. The mice in the study survived into adulthood and were free from the effects of MMA.
"The corrected gene delivered by AAV is the most effective therapy we have developed so far to treat MMA," said Charles Venditti, M.D., Ph.D., senior author and investigator in NHGRI's Genetic and Molecular Biology Branch. "However, we have identified an important safety parameter related to the AAV gene therapy in our mouse models that is critical to understand before we move to human patient trials."
Now, in a long-term follow-up of the treated mice — after mice reached about two years of age — the researchers documented a 50-70 percent higher occurrence of liver cancer in AAV-treated mice compared with a 10 percent liver cancer rate in untreated mice. Dr. Venditti's team determined that the AAV vector triggered the cancer.
The research team performed additional experiments to detect where in the mouse genome the AAV vector delivered the corrected gene and how that related to any cancer development. In many mice that developed liver cancer, the AAV vector targeted a region of the mouse genome called Rian, near a gene called Mir341 that codes for a microRNA molecule. MicroRNAs are small, non-coding RNA molecules involved in the regulation of gene expression. When the AAV was inserted near Mir341, the vector caused elevated expression of the gene, which the researchers believe contributed to the occurrence of liver cancer in the mice. The authors note that Mir341 is found in the mouse genome, however, it is not present in humans.
When the researchers used an alternate AAV vector to deliver the corrected gene in a study of just 10 mice, that vector did not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. The researchers found that this modification was a safer gene therapy.
"These studies will help us move forward to develop safer gene therapy for methylmalonic acidemia," said Randy Chandler, Ph.D., lead author and NHGRI staff scientist. "Most of the AAV integrations that caused liver cancer landed in a gene that is not found in the human genome, which suggests that the cancers we observed after AAV gene therapy may have been a mouse-specific phenomenon. However, these studies do convincingly demonstrate that AAV can be a cancer-causing agent, which argues for further studies."
The researchers also observed that lower doses of AAV resulted in reduced rates of liver cancer compared to a control group of mice. Their data showed that the rate of cancer dropped in proportion to the dose of the AAV.
Dr. Venditti hopes that methodologies described in his team's research will be used by others to study the toxicity of AAV vectors in their preclinical trials.
NHGRI is one of the 27 institutes and centers at the NIH, an agency of the Department of Health and Human Services. The NHGRI Division of Intramural Research develops and implements technology to understand, diagnose and treat genomic and genetic diseases. Additional information about NHGRI can be found at its website, http://www.genome.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIH…Turning Discovery Into Health®


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Easyjet has announced summer 2021 flights to Europe for less than £20 - here's when you can book
This article contains affiliate links. We may earn a small commission on items purchased through this article, but that does not affect our editorial judgement.
An easing of lockdown restrictions in the UK is yet to be announced, but many will be itching to start the process of returning to some form of normality.
And, for a large number of us, one of the most exciting prospects of lockdown lifting is the prospect of travelling again, after facing a huge bout of flight cancellations.
If you are already dreaming about your next trip abroad, Easyjet has issued its summer 2021 flight schedule earlier than usual, with routes to Europe priced from just £18.49.
What flights are available?
The flights that are now available cover the period from 19 April to 4 May 2021, with many costing less than £20.
More than 28,000 flights are on offer, following the early season launch of the airline's Easter schedule last month.
Destinations on the summer 2021 schedule include Croatia, Greece, Cyprus, Italy, Portugal, Turkey and Spain, among other European destinations.
Flights start from as little as £18.49 to Munich, while other bargains to Malaga and Alicante can be found for less than £25.
When will flights resume?
All flights are currently suspended due to coronavirus, with no official date as to when they will resume, although Easyjet has said restarting flights won't be considered until after May.
However, the airline has launched holidays until 2021 to allow customers who already have trips booked to move them to another date.
It has also waived the change fee for flights and holidays for all bookings to allow customers to move their dates free of charge. You can amend your booking online, via the Manage Bookings section.
When can I book flights?
Easyjet won't be selling any tickets for flights before 18 May, and will be relying on the latest travel advice from the UK Foreign and Commonwealth Office (FCO) to inform when it will restart operations.
In an email sent to customers and reportedly seen by the Liverpool Echo, Johan Lundgren CEO of Easyjet said, "Since we grounded our fleet a few weeks ago, almost all of Europe has been in lockdown.
"And whilst it gives us all encouragement that some countries are coming out the other side, there is still a great deal of uncertainty about when Europe will start opening up again.
"As we get a better understanding of when we'll re-start flying, we will let you know – however, we're not currently selling any tickets for flights before 18th May.
"Cancellations are being evaluated daily, and if your flight does get cancelled, you'll be notified at least seven days in advance."
Can I get a refund on cancelled flights?
Easyjet said it is processing refund requests as quickly as possible, but the sheer volume of flight cancellations has meant many customers have been faced with delays.
Customers have been given the option of redeeming a flight voucher instead, which can be used for bookings any time over the next 12 months, for flights over the next two years.
This includes the airline's recently released Easter 2021 and summer 2021 schedule, which will soon be on sale. For further information on holiday bookings, visit the easyJet website.


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1. Why are movie file sizes higher than available on other sites?
We use the best settings to convert the file. We use a bitrate of 180kbps for the videos so that the quality remains watchable even on bigger screen mobile. Also higher bitrate helps in case of high motions scenes.
2. How to stream movies online through a smartphone?
is the best option to stream movies online through a Android cell phone.
Click on the Download Link > When a box pop up select MxPlayer and the movie will start streaming as soon as it loads
3. How to stream movies online through a PC?
The file are available in basically 2 formats, 3gp and mp4.
3gp is best suited for basic mobile phones. It will ideally play on all mobiles and has the lowest size. We convert them using the mpeg4 codec with a bitrate of approx 180k. The audio is of 32k, optimum for mobile phones.
Mp4 is available in 2 forms. We use the h264 codec, considered one of the best, for converting videos. The first form is
a) baseline (regular) - It would support all phones which are capable of playing h264 level 1.3 file formats. We use 210k bitrate and have an aspect ratio of 16:9 and scale of 480x270 for the videos.
This format is best for medium range phones. All Android and Apple phones would support this format.
b) High mp4 (best quality). This is converted with bitrate of 250k using h264 high profile.
The best quality video and is best for high end phones, tablets, ipads and even a pc.
Converted in 640x scale.
this page
to know if your mobile supports the baseline or the High mp4 format.
4. Supported player for Android.
We recommend
which is available in Play Store(AKA Android Market) which is a free application and compatible with all Android Devices.
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8. How to stream movies online through a PC?
There are several ways to streat(watch) movies online. Here are some
You can even watch movies by using
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Flash Player
Google Chrome does not require Flash Player as it has inbuild flash player. Other browser such as Firefox, Safari, Opera may be needing flash player to stream movies online Once who have installed flash player you just need to do is click on the download link..Movie will start streaming in Browser it self.
Quick Time:
You can even watch movies by using
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Quike Time installs in every browser by it self, Soo once who have installed Quick Time you just need to do is click on the download link..Movie will start streaming in Browser it self.
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Experts call it "the greatest mammoth find ever," and it's coming to Victoria's Royal BC Museum.
The RBCM is unveiling a 40,000-year-old baby woolly mammoth in remarkable condition as part of its Giants of the Ice Age exhibit opening June 3.
Museum CEO Jack Lohman said it's Canada's first opportunity to see the ancient, majestic creature, dubbed Lyuba, after it was discovered in the Siberian Arctic in 2007.
"This is the best preserved baby mammoth ever found. We're hugely excited to have brought it from Russia to show the public here," Lohman said. "In a way, it brings us a step closer to understanding the disappearance of the mammoth, and it allows us to time travel to the great ice age."
The female mammoth was only 30 days old, 110 pounds and just over one-metre-long when she suffocated after becoming trapped in mud along the banks of a river, according to scientists.
Her body was preserved by lactic acid-producing bacteria, a microbial process that "pickled" her soft tissues.
Soft tissue sample and an analysis of her tusks suggest she was healthy at the time.
"She has her complete skin. You can see her eyelashes very, very clearly. She's got hair. And the whole contents of her gut exist and have been examined," Lohman said.
He called it one of the most important exhibitions the museum has every hosted.
Lyuba is on loan from the Shemanovskiy Yamal-Nenets District Museum in northern Siberia, Russia.
The exhibition opens next Wednesday and continues through to the end of 2016.


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More EHR Tech Support May Improve Patient Care
Study finds that physicians who got less assistance failed to raise their quality scores in New York project.
7 Big Data Solutions Try To Reshape Healthcare
7 Big Data Solutions Try To Reshape Healthcare (click image for larger view and for slideshow)
Primary care physicians in underserved New York neighborhoods who received a fair amount of technical assistance were more likely than those who received less or no assistance to use their electronic health records to improve the quality of care, according to a Health Affairs study from Weill Cornell Medical College investigators.
The researchers looked at participants in New York's Primary Care Improvement Project (PCIP), a city program that began in 2005 and became a federally funded regional extension center (REC) in 2011. PCIP subsidized the cost of EHRs for physicians in underserved areas of New York. The doctors had to buy an eClinicalWorks EHR that had been modified to emphasize preventive care. PCIP provided technical assistance and coaching on quality improvement.
To measure the impact of the EHR and the technical assistance on quality of care, Weill Cornell researchers used a statewide database of paid claims from several health plans. Based on that data, they compared the changes in performance on PCIP's quality measures to changes in performance by matched controls who were physicians outside of PCIP.
Andrew Ryan, lead author on the paper and an assistant professor of public health at Weill Cornell Medical College, told InformationWeek Healthcare that the researchers didn't know whether the comparison practices had EHRs or not. But because they were small primary care practices in underserved areas (not necessarily in New York), he surmised that many or most of them lacked EHRs.
[ Is it time to re-engineer your clinical decision support system? See 10 Innovative Clinical Decision Support Programs. ]
The study results included quality improvement on all 10 of the PCIP measures and quality improvement on "EHR-sensitive" measures that previous studies had shown could be affected by the use of EHRs. Among these measures were breast cancer screening for women, retinal exam for patients with diabetes, chlamydia screening for women and colorectal cancer screening.
The researchers found that for all quality measures, PCIP was not significantly associated with quality improvement at any interval from 6 to 24 months after EHR implementation, regardless of how much technical assistance the physicians received. For the EHR-sensitive measures, quality improvement occurred in practices that received at least eight technical assistance visits and had been using the EHR for more than nine months. Quality did not improve in practices that received low or moderate amounts of assistance.
One implication of this study, according to Ryan, is that physicians need a lot of help to learn how to use their EHRs in quality improvement. To start with, Ryan said, there's a cultural barrier. "You've got a cohort of physicians who are used to practicing in a certain way and have been doing that their whole careers." They may not be computer savvy, Ryan pointed out, and to achieve the full potential of EHRs, they have to change how they document visits, how they write prescriptions, and how they decide what type of treatment patients get.
The PCIP practices' EHR included clinical decision support to alert them when patients were due for certain kinds of preventive or chronic care. But in general, Ryan said, physicians may ignore alerts when there are too many of them.
An earlier study of PCIP found that a large percentage of diagnoses were not documented as discrete data; as a result, PCIP practices underreported the services provided by doctors on six of 11 preventive care measures. This finding could provide another explanation for the apparent lack of quality improvement in many of the practices in the Weill Cornell study.
Could the study findings be applied to RECs elsewhere in the country that help physicians learn how to use their EHRs? PCIP predated the other RECs, Ryan noted, but it helped practices with few resources do a better job for patients in poor neighborhoods.
"PCIP was implemented under very challenging circumstances. And we found some evidence that for certain kinds of measures with a lot of technical assistance, it can improve quality. If it can be done in New York with difficult practices, it could be done in other places."
Clinical, patient engagement, and consumer apps promise to re-energize healthcare. Also in the new, all-digital Mobile Power issue of InformationWeek Healthcare: Comparative effectiveness research taps the IT toolbox to compare treatments to determine which ones are most effective. (Free registration required.)
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Five killed in apparent Beirut car bombing
An explosion rocked a stronghold of the Shiite Hezbollah group in the southern suburbs of the Lebanese capital, killing at least five people, setting cars ablaze and sending a column of black smoke above the Beirut skyline.
The nature of the explosion that hit during rush hour in the Haret Hreik neighborhood was not immediately clear, but a Lebanese security official said it appeared to be caused by a car bomb.
If confirmed as a bombing, then it would be the latest in a wave of attacks to hit Lebanon in recent months as the civil war in Syria increasingly spills over into its smaller neighbor. The attacks have targeted both Sunni and Shiite neighborhoods, further stoking sectarian tensions that are already running high because of the war next door.
Lebanon's Health Ministry said at least five people were killed and 20 wounded in the explosion, which left the mangled wreckage of cars in the street and blew out the windows of store fronts.
Images broadcast on Hezbollah's Al-Manar TV showed firefighters putting out the smoldering hulks of several cars that had been set ablaze. The footage showed at least one building that had part of its facade blown off, and several neighboring buildings were also damaged.
Al-Manar said the explosion occurred "a few hundred meters (yards) from the politburo of Hezbollah." It said the political office was not the target of the blast.
Hezbollah security agents as well as Lebanese troops were trying to cordon off the area to keep the angry crowds away from the blast site.
"Suddenly, the whole area went bright and we started running away," Ali Oleik, an accountant who works in a nearby office building, told The Associated Press. "I saw two bodies on the street, one of a woman and another of a man on a motorcycle who was totally deformed."
Authorities brought out bomb sniffing dogs, and at one point announced that there might be another bomb, setting the crowd scattering in panic from the area.
The explosion comes a week after a car bombing in downtown Beirut killed a prominent Sunni politician who had been critical of Syrian President Bashar Assad and his Hezbollah allies.
Hezbollah's once seemingly impenetrable bastion of support — Beirut's southern suburbs — also has been hit several times in recent months.
The Haret Hreik neighborhood where Thursday's explosion took place is close to the Beir al-Abed district where a powerful car bomb in August killed nearly 20 people.
The attacks raise the specter of a sharply divided Lebanon being pulled further into the Syrian conflict, which is being fought on increasingly sectarian lines pitting Sunnis against Shiites. Syria-based Sunni rebels and militant Islamist groups fighting to topple Assad have threatened to target Hezbollah strongholds in Lebanon in retaliation for intervening on behalf of his regime in the conflict.


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Posted by Cody_McDaniel
It's no secret that B2B marketing is different than B2C. The sales cycle is longer, there are multiple stakeholders involved, and it's usually more expensive. To market effectively, you need to create content that helps, educates, and informs your clientele. The best way to do that is to identify the keywords that matter most to them, and build out content accordingly.
To find out how, watch this week's episode of Whiteboard Friday!
Click on the whiteboard image above to open a high resolution version in a new tab!
Video Transcription
Hi and welcome to another Whiteboard Friday. My name is Cody McDaniel, and I'm an SEO manager at Obility. We are a B2B digital marketing agency, and today I want to talk about selecting meaningful B2B SEO keyword targets and the process and steps you can take in your own keyword research.
So B2B is a little bit different than you would see in your normal B2C types of marketing, right? The sales cycle or the length of time it takes to actually make a purchasing decision is usually a lot longer than you would see just buying something off Amazon, right? It's going to take multiple stakeholders. Individuals are going to be involved in that process. It's going to be usually a lot more expensive.
So in order to do that, they're going to want to be informed about their decision. They're going to have to look up content and information across the web to help inform that decision and make sure that they're doing the right thing for their own business. So in order to do that, we have to create content that helps, educates, and informs these users, and the way to do that is finding keywords that matter and building content around them.
1. Gather seed list
So when we're developing keyword research for our own clientele, the first thing that we do is gather a seed list. So usually we'll talk with our client contact and speak to them about what they care about. But it also helps to get a few other stakeholders involved, right, so the product marketing team or the sales team, individuals that will eventually want to use that information for their clients, and talk with them about what they care about, what do they want to show up for, what's important to them.
That will sort of help frame the conversation you want to be having and give you an understanding or an idea of where eventually you want to take this keyword research. It shouldn't be very long. It's a seed list. It should eventually grow, right?
2. Review your content
So once you've done that and you have a baseline understanding of where you want to go, the next thing you can do is review the content that you have on your own website, and that can start with your homepage.
What's the way that you describe yourselves to the greater masses? What's the flagship page have to say about what you offer? You can go a little bit deeper into some of your other top-level pages and About Us. But try to generate an understanding of how you speak to your product, especially in relation to your clients in the industry that you're in. You can use that, and from there you can go a little bit further.
Go through your blog posts to see how you speak to the industry and to educate and inform individuals. Go to newsletters. Just try to get an understanding of what exists currently on the website, where your efficiencies may be, and of course where your deficiencies are or your lack of content. That will help you generate ideas on where you need to look for more keywords or modifications in the keywords you have.
3. Determine your rankings
Speaking of which, with the keywords that you currently have, it's important to know how you stand. So at this point, I try to look to see how we're ranking in the greater scheme of things, and there are a lot of different tools that you can use for that. Search Console is a great way to see how potential users across the web are going to your website currently. That can help you filter by page or by query.
You can get an understanding of what's getting clicks and generating interest. But you can also use other tools — SEMrush, SpyFu, Ahrefs, and Moz, of course. They'll all give you a keyword list that can help you determine what users are searching for in order to find your website and where they currently rank in the search engine results page. Now usually these lists are pretty extensive.
I mean, they can be anything from a few hundred to a few thousand terms. So it helps to parse it down a little bit. I like to filter it by things like if it has no search volume, nix it. If it's a branded term, I don't like to include it because you should be showing up for your branded terms already. Maybe if it's outside the top 50 in rankings, things like that, I don't want that information here right now.
4. Competitive research
I want to understand how we're showing up, where our competencies are, and how we can leverage that in our keyword research. So that should help the list to be a little bit more condensed. But one of the things you can also look at is not just internal but external, right? So you can look at your competition and see how we're ranking or comparing at least on the web.
What do they use? What sort of content do they have on their website? What are they promoting? How are they framing that conversation? Are they using blog posts? All that information is going to be useful for maybe developing your own strategies or maybe finding a niche where, if you have particularly stiff competition, you can find areas they're not discussing.
But use that competition as a framework for identifying areas and potential opportunities and how the general public or industry speaks to some of the content that you're interested in writing about. So once you have that list, it should be pretty big, good idea of the ecosystem you're working with, it's important to gather metrics.
5. Gather metrics
This is going to contextualize the information that you have, right? You want to make informed decisions on the keywords that you have, so this metric gathering will be important. There are a lot of different ways you can do it. Here at Obility, we might categorize them by different topic types so we can make sure that we're touching on all the different levels of keyword usage for the different topics that we discuss in our content.
You can look at things like search volume. There a lot of different tools that do that, the same ones I mentioned earlier — Moz, SpyFu, SEMrush. There's a great tool we use called Keyword Keg, that kind of sort of aggregates all of them. But that will give you an idea search volume on a monthly basis. But you can also use other metrics, things like difficulty, like how hard it is to rank compared to some of the other people on the web, or organic click-through rate, like what's the level of competition you're going to be going up against in terms of ads or videos or carousels or other sort of Google snippets.
Moz does a great job of that. So use these metrics, and what they should help you do is contextualize the information so that maybe if you're pretty close on two or three keywords, that metric gathering should help you identify which one is maybe the easiest, it has the most potential, so on and so forth. So once you have that, you should be getting a good understanding of where each of those keywords lives and you should be selecting your targets.
6. Select target keywords
Now I've run through a ton of clients who former agencies have sent them a list of 300 to 400 keywords that they're trying to rank for, and I cannot stand it. There's no value to be had, because how can you possibly try and optimize and rank for hundreds and hundreds of different variations of keywords. It would take too long, right? You could spend years in that rabbit hole.
What we try to do is focus on maybe 30 or 40 keywords and really narrow down what sort of content is going to be created for it, what you need to optimize. Does it exist on your website? If not, what do we need to make? Having that list makes a much more compartmentalized marketing strategy, and you can actually look at that and weigh it against how you're currently deploying content internally.
You can look at success metrics and KPIs. It just helps to have something a little bit more tangible to bite down on. Of course, you can grow from there, right? You start ranking well for those 20 or 30 terms, and you can add a few more on at the end of it. But again, I think it's really important to focus on a very select number, categorizing them by the importance of which ones you want to go first, and start there because this process in content creation takes a long time.
7. Consider intent
But once you've selected those, it's also important to consider intent. You can see I've outlined intent here a little bit more in depth. What do I mean by that? Well, the best way that I've seen intent described online is as an equation. So every query is made up of two parts, the implicit and the explicit. What are you saying, and what do you mean when you're saying it?
So when I think of that and trying to relate it to keywords, it's really important to use that framework to develop the strategy that you have. An example that I have here is "email marketing." So what's the implicit and explicit nature of that? Well, "email marketing" is a pretty broad term.
So implicitly they're probably looking to educate themselves on the topic, learn a little bit more about what it's about. You'll see, when you search for that, it's usually a lot more educational related content that helps the user understand it better. They're not ready to buy yet. They just want to know a little bit more. But what happens when I add a modifier on it? What if I add "software"? Well, now that you would have intent, it may mean the same thing as email marketing in some context, but software implies that they're looking for a solution.
We've now gone down the funnel and are starting to identify terms in which a user is more interested in purchasing. So that type of content is going to be significantly different, and it's going to be more heavily implied on features and benefits than just the email marketing. So that intent is important to frame your keywords, and it's important to make sure that you have them in every step of your purchasing funnel.
The way that I like to usually look at that, and you see it everywhere, it's an upside down triangle. You have your top, middle, and bottom level pieces of content. Usually the top is going to be things like blogs and other sorts of informational content that you're going to be having to use to inform users of the types of topics and things in the industry you care about.
That's probably where something like "email marketing" would exist. But "email marketing software" is probably going to be sitting right here in the middle, where somebody is going to want to make an informed decision, relate it to other pieces of content on competitor websites, check those features, and determine if it's a useful product for them, right? From there, you can go a little bit further and move them into different types of content, maybe email marketing software for small business.
That's far more nuanced and specific, and maybe you'll have a white paper or a demo that's specifically tailored to businesses that are looking for email marketing in the small business space. So having content in three separate spaces and three different modifications will help you identify where your content gaps are and make sure that users can move throughout your website and throughout the funnel and inform themselves on the decision they're trying to make.
So with that, this should give you some idea of how we develop keyword research here at our own agency, and I hope that you guys can utilize some of these strategies in your own keyword research wherever you are out in the world. So thanks again for listening. Happy New Year. Take care.
Video transcription by Speechpad.com
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Ronald McDonald House Charities of Southern California (RMHCSC) is pleased to provide information to all of its customers about its privacy policy. Please be assured that RMHCSC uses its best efforts regarding privacy protection and data security.
Types of Information Collected and How It Is Used
RMHCSC gathers personal information, such as first and last names, home addresses, e-mail addresses and credit card numbers, only when voluntarily submitted by you. If you make a donation, personal information will be collected from you in order to process that donation.
With your permission, we will use personal information collected from you to send you information, such as RMHCSC updates or information regarding new Ronald McDonald House openings, fund-raising campaigns or major grant initiatives. If you do not elect to receive such materials, we will not send them to you.
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Donor information is stored within a donor management database within RMHC. Access to the database is restricted to personnel with a legitimate business need to access or modify the information contained therein.
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Companies may be engaged by RMHCSC to perform a variety of functions, such as assisting with donation collection, providing technical services for our Internet sites, etc. Such companies may have access to personal information if needed to perform certain functions. However, these companies may use such personal information only for the purpose of performing that function and may not use it for any other purpose. Other than as provided in this privacy policy, RMHCSC does not sell, transfer or disclose personal information to third parties.
RMHCSC reserves the right to use or disclose any information as needed to satisfy any law, regulation or legal request, to protect the integrity of the site, to fulfill your requests, or to cooperate in any law enforcement investigation or an investigation on a public safety matter.
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We may offer links to sites that are not operated by RMHCSC. If you visit one of these linked sites, you should review their privacy and other policies. We are not responsible for the policies and practices of other companies.
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Each local Chapter of Ronald McDonald House Charities (RMHC) and local Ronald McDonald House, Ronald McDonald Family Room and Ronald McDonald Care Mobile program is an independent organization and licensee of RMHC. Many of these local programs and local Chapters operate their own Internet sites. When visiting the Internet site of other local RMHC Chapters or local House, please review the site's privacy policy because the terms may be different from this privacy policy.
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Our privacy policy became effective on April 12, 2018. From time to time, it may be necessary for RMHC to change its privacy policy, so we suggest that you check here periodically. Rest assured, however, that any changes will not be retroactively applied and will not alter how we handle previously collected information.
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Iapetus Global View
Within Cassini Regio, and especially near the equator, dark deposits with a visual reflectivity of only about 4 percent coat nearly everything with remarkable uniformity. However, at latitudes of about 40 degrees, the surface transitions to a much brighter, icy terrain near the pole where the brightest icy materials have reflectivity over 60 percent. However, this region is not uniform: Close inspection reveals that the surface is stained by crudely north-south trending wispy streaks of darker material, typically a few kilometres wide and sometimes tens of kilometres long.
An ancient, 400-kilometer wide impact basin appears just above the centre of the disc. The basin is heavily overprinted by more recent, smaller impact craters. The basin rim is delineated by steep scarps that descend to the basin floor. Many of these scarps, as well as walls of nearby craters, appear bright, probably due to exposed outcrops of relatively clean ice. Particularly at mid-latitudes, the brightest scarp exposures appear to face away from the equator (toward the pole). Often, the opposite south-facing scarps are stained with the lower-brightness material.
The most unique, and perhaps most remarkable feature discovered on Iapetus in Cassini images is a topographic ridge that coincides almost exactly with the geographic equator. The ridge is conspicuous in the picture as an approximately 20-kilometer wide band that extends from the western (left) side of the disc almost to the day/night boundary on the right. On the left horizon, the peak of the ridge reaches at least 13 kilometres above the surrounding terrain. Along the roughly 1300 kilometre length over which it can be traced in this picture, it remains almost exactly parallel to the equator within a couple of degrees. The physical origin of the ridge has yet to be explained. It is not yet clear whether the ridge is a mountain belt that has folded upward, or an extensional crack in the surface through which material from inside Iapetus erupted onto the surface and accumulated locally, forming the ridge.
The origin of Cassini Regio is a long-standing debate among scientists. One theory proposes that its dark material may have erupted onto Iapetus's icy surface from the interior. Another theory holds that the dark material represented accumulated debris ejected by impact events on dark, outer satellites of Saturn. Details of this Cassini image mosaic do not definitively rule out either of the theories. However, they do provide important new insights and constraints.
The uniform appearance of the dark materials at the equator, the apparent thinning and spottiness of the dark materials at progressively higher latitudes and dark wispy streaks near the distal margin of Cassini Regio strongly suggest that dark material was emplaced as a coating. One of the important new results is that no clear evidence can be found that erupted fluids have resurfaced Cassini Regio. The high density of impact craters argues that the terrain underlying the dark coating is relatively ancient and has not been eradicated by its emplacement. Thus, Cassini Regio may have had its origin in plume-style eruptions in which dark particulate materials accumulated on the surface as fallout, perhaps in conjunction with the creation of the equatorial ridge. On the other hand, the dark deposits in Cassini Regio may be a surface coating consistent with, and perhaps more simply explained by, the fall of dark materials from outside. The view has been oriented so that the north pole is toward the top of the picture.
Cassini acquired the images in this mosaic with its narrow angle camera on 31 December 2004, at a distance of about 172 400 kilometres from Iapetus and at a Sun-Iapetus-spacecraft, or phase, angle of 50 degrees. The image scale is 1 kilometre per pixel. The image has been contrast enhanced to aid visibility of surface features.
The Cassini-Huygens mission is a cooperative project of NASA, the European Space Agency and the Italian Space Agency.


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A big hello to everyone, I apologise if this is not the appropriate section of the forum.
We are a London based startup developing a Pub ordering app and are looking for early testers.
Short description of the app:
We offer a Mobile app (Android and iOS), branded with your Pub logo, slogan and contact information which is easily installable from Play/Apple store. You get a new App on Apple and Play store which is specific for your Pub.
Customers will be able to view the menu, order and pay for food and drinks and much more.
Pub owners will be able to notify all app users with latest news, offers and promotions. The app will also offer some other features that can help grow your business.
Everything is managed through a easy to use back office.
All early testers will get the App absolutely free with no setup costs and no monthly costs for the first year and will also be able to influence the development of new features to a certain extent.
As we are still in closed beta, we will share more information directly with pub owners who would like to test our App.
Please let us know if you are interested, so we can get in touch.


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You're viewing documentation for a previous version of ScyllaDB Open Source. Switch to the latest stable version.
This document is a step by step procedure for upgrading from Scylla 3.3 to Scylla 4.0, and rollback to 3.3 if required.
This guide covers upgrading Scylla from the following versions: 3.3.x or later to Scylla version 4.0.y on the following platform:
Ubuntu 16.04
Execute the following commands one node at the time, moving to the next node only after the upgrade procedure completed successfully.
If you are using CDC and upgrading Scylla 4.3 to 4.4, please review the API updates in querying CDC streams and CDC stream generations. In particular, you should update applications that use CDC according to CDC Upgrade notes before upgrading the cluster to 4.4.
If you are using CDC and upgrading from pre 4.3 version to 4.3, note the upgrading from experimental CDC.
A Scylla upgrade is a rolling procedure which does not require full cluster shutdown. For each of the nodes in the cluster, you will:
Check cluster schema
Drain node and backup the data
Backup configuration file
Stop Scylla
Download and install new Scylla packages
Start Scylla
Validate that the upgrade was successful
Apply the following procedure serially on each node. Do not move to the next node before validating the node is up and running with the new version.
During the rolling upgrade it is highly recommended:
Not to use new 4.0 features
Not to run administration functions, like repairs, refresh, rebuild or add or remove nodes. See sctool for suspending Scylla Manager (only available Scylla Enterprise) scheduled or running repairs.
Not to apply schema changes
Before upgrading, make sure to use Scylla Monitoring 3.1 or newer, for the Dashboards.
Make sure that all nodes have the schema synched prior to upgrade, we won't survive an upgrade that has schema disagreement between nodes.
nodetool describecluster
Before any major procedure, like an upgrade, it is recommended to backup all the data to an external device. In Scylla, backup is done using the nodetool snapshot
command. For each node in the cluster, run the following command:
nodetool drain
nodetool snapshot
Take note of the directory name that nodetool gives you, and copy all the directories having this name under /var/lib/scylla
to a backup device.
When the upgrade is complete (all nodes), the snapshot should be removed by nodetool clearsnapshot -t <snapshot>
, or you risk running out of space.
sudo cp -a /etc/scylla/scylla.yaml /etc/scylla/scylla.yaml.backup-|SRC_VERSION|
sudo service scylla-server stop
Before upgrading, check what version you are running now using dpkg -s scylla-server
. You should use the same version in case you want to rollback the upgrade. If you are not running a 3.3.x version, stop right here! This guide only covers 3.3.x to 4.0.y upgrades.
To upgrade:
Update the Scylla deb repo to 4.0, and enable scylla/ppa repo
Ubuntu 16:
sudo add-apt-repository -y ppa:scylladb/ppa
Config java to 1.8, which is requested by Scylla 4.0
sudo apt-get update
sudo apt-get install -y openjdk-8-jre-headless
sudo update-java-alternatives -s java-1.8.0-openjdk-amd64
sudo apt-get update sudo apt-get dist-upgrade scylla
Answer 'y' to the first two questions.
Alternator users upgrading from Scylla 4.0 to 4.1, need to set default isolation level
sudo service scylla-server start
Check cluster status with nodetool status
and make sure all nodes, including the one you just upgraded, are in UN status.
Use curl -X GET "http://localhost:10000/storage_service/scylla_release_version"
to check scylla version.
Check scylla-server log (by journalctl _COMM=scylla
) and /var/log/syslog
to validate there are no errors.
Check again after 2 minutes, to validate no new issues are introduced.
Once you are sure the node upgrade is successful, move to the next node in the cluster.
Execute the following commands one node at the time, moving to the next node only after the rollback procedure completed successfully.
The following procedure describes a rollback from Scylla release 4.0.x to 3.3.y. Apply this procedure if an upgrade from 3.3 to 4.0 failed before completing on all nodes. Use this procedure only for nodes you upgraded to 4.0
Scylla rollback is a rolling procedure which does not require full cluster shutdown. For each of the nodes rollback to 3.3, you will:
Drain the node and stop Scylla
Retrieve the old Scylla packages
Restore the configuration file
Restore system tables
Reload systemd configuration
Restart Scylla
Validate the rollback success
Apply the following procedure serially on each node. Do not move to the next node before validating the node is up and running with the new version.
nodetool drain
sudo service scylla-server stop
Remove the old repo file.
sudo rm -rf /etc/apt/sources.list.d/scylla.list
Update the Scylla deb repo to 3.3
sudo apt-get update sudo apt-get remove scylla* -y sudo apt-get install scylla
Answer 'y' to the first two questions.
sudo rm -rf /etc/scylla/scylla.yaml
sudo cp -a /etc/scylla/scylla.yaml.backup-|SRC_VERSION| /etc/scylla/scylla.yaml
Restore all tables of system and system_schema from previous snapshot, 4.0 uses a different set of system tables. Reference doc: Restore from a Backup and Incremental Backup
cd /var/lib/scylla/data/keyspace_name/table_name-UUID/snapshots/<snapshot_name>/
sudo cp -r * /var/lib/scylla/data/keyspace_name/table_name-UUID/
sudo chown -R scylla:scylla /var/lib/scylla/data/keyspace_name/table_name-UUID/
Require to reload the unit file if the systemd unit file is changed.
sudo systemctl daemon-reload
sudo service scylla-server start
Check upgrade instruction above for validation. Once you are sure the node rollback is successful, move to the next node in the cluster.


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What I'm getting at is that some people have unusual bathroom habits. One of THE most annoying I've already wrote a commentary on . . . and that is people who feel the need to chat on the phone while they're going potty. I won't get into that again.
What I don't understand is the women who come into the bathroom who flush the toilet first thing . . . I'm talking as soon as they enter the stall. You may argue that perhaps the last person to use the toilet failed to flush when they were done doing their duty (or doodie, as it were). But I really don't think that's the case. I walk by those toilets on the way to my preferred stall . . . yeah, I have one and it's the one furthest from the door; it's as close to privacy as I can get . . . and I have never ever seen an unflushed toilet before. I suppose I might pre-flush if there are skid marks in the bowl . . .
I can't even say that they're doing it to mask the sound of their . . . uhm . . . bodily functions. Because the flush happens before they do anything. Before the door is even latched. Before they've even dropped their drawers to tinkle.
I'm thinking that maybe . . . just maybe . . . they want really clean water in the case of back splash. I suppose it's possible that germs could splash up. But I also don't see how that extra flush could disinfect the toilet. Think about it . . . if the bowl already looks clean because the previous user flushed, and then you flush it again, how much cleaner is it really?
Perhaps it goes back to some childhood thing . . . like when mommy would turn on the water in the bathroom to help you go. It's a known fact that the sound of running water increases urgency in some people.
Meh . . .
And don't get me started on the people who put toilet paper on the seat so they don't have to touch the seat but then they leave the toilet paper there . . . because apparently it's okay for you to touch their germ-infested toilet paper to remove it.
That is all . . . moving on.


text: OriginLab Consulting ServicesOriginLab provides consulting services to customize and enhance Origin to meet your specific analysis and graphing needs. Our Applications engineers will work with you to design and implement your custom Origin solution. Contact us to obtain a quote for a specific task, or to learn more about our consulting services. Typical customization tasks handled by our consulting services include, but are not limited to: Customizing Data Import and Acquisition Custom routines for accessing data stored in databases Custom routines for importing data from files with custom ASCII/Binary formats Custom routines for sending data to Origin running as Automation Server, from client applications such as Microsoft® Excel, Microsoft® Visual Basic, Microsoft® Visual C++, LabVIEW, and MATLAB® Custom EXEs built using LabVIEW Application Builder to acquire data into Origin from devices (end user does not need to have LabVIEW installed) Customizing Graphing and Presentation Custom routines to create publication quality graphs Creating custom graph templates and themes Customizing Data Analysis Custom data analysis routines built using our Origin C and LabTalk programming languages Custom routines to access external DLLs for performing data analysis Automation, Batch Processing, and Report Generation Custom routines to automate your routine data analysis and graphing tasks Report generation routines that utilize COM client capability to send analysis and graphing results from Origin to Microsoft Office and other products Routines to perform batch processing of your data Customizing the Origin Interface Custom Tools, Dialogs, and Wizards built using our Dialog Builder and GetN Dialog Technology, for accessing specific Origin features or for accessing custom routines tailor-made to meet your specifications Customizing/Expanding Origin Menus and Toolbars Origin as Automation Server Creating applications in products such as Excel, Visual Basic, Visual C++, LabVIEW, and MATLAB, that access Origin as an Automation Server for performing custom analysis and graphing tasks OEM Customization Customize the entire Origin application to be integrated and packaged with your product for distribution. Click here to read more about Origin OEM. Learn how OriginLab's Consulting Services worked for Greenheck Fan, a leading manufacturer of ventilation equipment... Contact Us OriginLab can work with you in any capacity you need to customize Origin to suit your needs. Our Applications engineer can perform the work at your site or at OriginLab. Contact us to obtain a quote for a specific task, or to learn more about our consulting services.


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Someone Went Grocery Shopping in a T-Rex Costume – Made Everyone's Day
Why doesn't anything amazing like this happen at my grocery store? The most excitement I get is a weird robot following me around that refuses to adhere to social distancing guidelines.
Shoppers at the Hannaford in Hampstead, New Hampshire got a real treat when they saw this T-Rex casually shopping in the produce department. "And on the 6th day of quarantine, the dinosaurs reclaimed the earth".
Here are some of my favorite comments:
- Kathleen Doherty Ivanowski: Is this the common Tryanna-Hoard-A-Sus, or the less common Tryanna-Share-A-sSus?
- Dawn Gilger: This definitely made work a lot more fun today. Whoever that was... Thank you!!! 😅
- Jack Donovan: I had heard that the Produce Manager was a real dinosaur...guess that true 😉😀!
A little fun never hurt nobody! Whoever the person is inside this T-Rex costume, you are awesome. You have not lost your sense of humor throughout all of this and I commend you.


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Dylan Scott Reveals What Is Most Likely (Almost Definitely) Going to Be His Daughter's Name
Dylan Scott's baby girl is set to arrive in September, and he and wife Blair are as ready as they can be. Baby girl will be their second child following Beckett, who was born in Dec. 2017.
The "Nothing to Do Town" singer feels comfortable enough with the name they've chosen to finally share it. Talking to Taste of Country Nights, Scott was hesitant for a moment before offering the exclusive.
"I'll just tell you what I want," he shares. "This is what I want it to be and I think she wants it to be this too so I'll just go ahead and put it out there: Finley Gray."
It's official now! Finley Gray Robinson (Scott's real last name) is coming next month!
Scott and Blair revealed in March that they were expecting, and then revealed it's a girl one month later with a sweet Instagram video. Scott admits he was shocked to learn he'd be a girl-dad soon. Actually, he was shocked to learn he'd be a father again so soon!
"My son wasn't even a year old yet and she comes to me — after telling me she don't want any more kids — she said, 'Let's have another kid,'" he says, smiling. "(I) Figured it would take awhile. Have a kid when Beckett was two ... No, immediately man. Fertile Myrtle over there, so immediately she told me."
On Aug. 16, Scott celebrated the release of his new EP of Keith Whitley covers called An Old Memory. In the video above he talks about how the late legend helped him land a record deal and tells a story of one of Whitley's final songs, a loving song to his wife Lorrie Morgan called "Tell Lorrie I Love Her."
Watch: We Think You'll Love This Keith Whitley Cover!
These Are the Hottest Men in Country Music:


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Proven Business Relationship Agreement – Part 1
Proven Business Relationship Agreement – Part 1
By DC Cordova
In this series of posts, I'm going to share with you what has worked for me in business for the last 30 years. I currently have business agreements with partners in China, Singapore, Malaysia, Australia and the United States. I've done business with well-known authors, speakers, artists, producers, film-makers, promoters, government ministries, large and small organizations – you name it. What I tell my clients is if you prepare for your business relationships, your partnerships, like you do marriage, then I can guarantee you a significantly higher success rate. This article contains steps 1 and 2 to creating a successful business relationship. Follow along, put it into practice and enjoy the fruits of clarity.
As all human beings have feelings, opinions, beliefs and emotions that can and do affect us in different ways in the various circumstances that make up our lives, I, _____________________ and I, _____________________ agree that as of this date: _______________________, we have read the chapter in What School Should have Taught You about Money & You and have fully discussed and hereby declare that we have discussed and are now fully aware of the following…
1. Be willing to make your partner happy
___ We have asked and told each other what makes each of us happy in business and personally.
___ We know what we can do to bother them and get the upset.
___ We are willing and committed to hear each other out – repeating the other's point of view before expressing our own opinion.
___ We are willing to have things go "their way" at times
___ We will consciously and clearly "agree to agree" or "agree to disagree" when necessary.
___ We will "share" in the way the business is run and agree to how that might look like.
2. Create joint ventures first before creating your business partnership.
___ We will go (or have not gone) into our partnership until we have worked on a few projects under "joint-venture" basis first.
___ We realize that this partnership/business venture is more like a marriage than anything is, and we will get to know each other like we would in a courtship.
___ I am willing to commit to my partner, as well as the business…
___ for a very long time.
___ through thick and through thin
___ to talk together and meet on a regular basis to evaluate how it is going
___ to call in a third party to facilitate when we don't see eye to eye and cannot resolve a conflict within 45 minutes.
___ to get to know each other first for at least ___ months or ___ years.
___ We will spend plenty of time together before moving on to larger commitments.
___ To see each other working under a variety of situations, both when things are going well and when they aren't.
___ To see each other when we are under pressure.
___ To spend time traveling together.
___ To get involved in activities together that will allow us to see how my potential partner(s) react under different situations.
___ To interview their old friends and ex-partners.
___ To attend several different types of seminars together, including intensive, long-term personal growth as well as business programs.
___ To learn how best to communicate with each other.
___ To work with a professional team builder and business coach to help us review or develop our business practices.
___ To develop a "language" we can use together.
___ To meet as soon as possible after each project we do together to review it, confirm what worked, list what didn't work, and commit to the change that each "learning experience" indicated is needed.
___ To correct my systems (or attitudes) and learn from them.
This may sound like a lot to agree on – and if you really read this, you do this in regular relationships before fully committing in a marriage. I encourage you to approach your business partnerships like a marriage because you are legally agreeing to be in partnership. And sometimes dissolving a business can be more destructive and time-consuming than divorce. So be prepared.
And as my old partner used to say, "If someone will cheat in their marriage, what would stop them from cheating in business?"
In my next post I'll share Steps 3 -9 in Proven Business Relationship Agreement – Part 2 …from "Get clear on your purpose" to "Who is going to do what?"
With loving thoughts,
DC Cordova
P.S. – Get Your Personal Entrepreneurial Strategy and take your business to the next level!
© Money & You® 2006 – 2009


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The PD is a power driver, designed to offer control and a reliable flight path in all conditions. It's possibly the best all-around driver for more advanced players. Newer players will also find use for the PD as a trusty overstable disc for headwind throws and flex shots. The PD is a fantastic choice for both backhand and forehand throws when extra accuracy is called for!
Color: Orange
Weight: 173 grams


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Podcast: Play in new window | Download
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Way back in February of 2020, I asked Darling Nisi and Harold Pride to record a third episode in our series of in-depth retrospectives on Prince's albums, this one for the 40th anniversary of 1980's Dirty Mind. The podcast was intended to predate De Angela Duff's DM40GB30 symposium, which in those simpler times was still scheduled to be held in-person at New York University.
Well, you know what happened next: DM40GB30 was delayed, then went virtual, while I slipped into a pandemic-related depression fog that only lifted, appropriately enough, after I participated in the virtual symposium back in June. Meanwhile, the podcast continued to lavish in the D / M / S / R Vault (a.k.a. the "Documents" folder on my computer) until the end of last month, when I was promptly reminded of just how laborious a task editing a three-hour podcast recording can be.
Now, the wait is finally over: the D / M / S / R podcast is back, in all its wildly self-indulgent glory. I want to thank everyone for their patience, and assure you that there won't be a two-year wait before the next episode; in fact, I'd recommend you go ahead and use one of the links above to subscribe on your podcast service of choice using one of the links above, because I'm aiming to put out one of these bad boys (i.e., podcasts, not necessarily review episodes) per month. As always, let me know what you think, and feel free to leave a review on your podcast provider if you're so inclined.


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While Parc Lafontaine has been around since 1874 or so, the town ponds connected by a waterfall were not introduced until 1900, and the fountain was built in 1929 because Léon Trépanier wanted one there, and was paid for by Westinghouse. I'm going to have to return next spring as at nighttime, it is illuminated.
+This is the 26th in an occasional series of videos on the fountains of Montreal+


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Divine Intimacy (Father Gabriel of St Mary Magdalen, OCD)
"This book of meditations is meant for all priests, seminarians, religious, the devout laity, all who aspire to greater union with God: that is, to divine intimacy." - Pope John XXIII
"This Book of Meditations on the interior life for every day of the liturgical year is a pearl of great price. For spiritual reading and personal prayer, it is a treasure, providing sound guidance on the journey of prayer, and a safe companion on the road to holiness and to intimate union with God." - Bishop Philip Boyce O.C.D, Bishop of Raphoe, Ireland.
This Book of Meditations is a classic and is seeped in Carmelite spirituality. For every day it offers two meditations, in liturgical arrangement, that enable the soul to enter the conscious presence of God and to reflect on the theme of the day. These are followed by a 'Colloquy' that helps the person at prayer to start a friendly conversation with God where acts of praise and love, petition and thanksgiving are made, together with good resolutions for the future. Here we are at the very heart of prayer, which is a heart-to-heart encounter in faith with the living God.
Divine Intimacy is the highest state attainable on earth. In this union of love, the soul produces acts of love which have an immense apostolic influence on a multitude of souls. This knowledge of the ways that lead to God, according to the teaching of the renowned Spanish mystics, is distilled into the pages of this book.
About the Author:
Father Gabriel of St. Mary Magdalen, O.C.D., was a Discalced Carmelite priest who became one of the most revered masters of the spiritual life. He acquired a vast knowledge of the ways that lead to holiness and to union with God. His experience with souls, whom he guided to the heights of perfection, was outstanding. He was an expert in the spiritual and mystical doctrine of St. Teresa of Jesus (Avila) and of St. John of the Cross. The Discalced Carmelite nuns of the Monastery of St. Joseph in Rome were the heirs of the Father Gabriel's vast output of published works and private manuscripts. For ten years, he guided these nuns as their confessor and spiritual director, and it was they who helped him to arrange his material in line with the course of the liturgical year, while following the ascent of the soul to transforming union with God, or to 'Divine Intimacy.'


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Ways to pray
- Pray that God would intervene and the Gospel will spread in this region exponentially
- Pray for the people of Ukraine
- Pray for those fleeing the border areas and those receiving refugees
PrayforEurope.live is a place where missionaries share specific updates on what is unfolding in the Ukraine and guides to how we can pray and help.
With the crisis affecting families,
reaching Europe is critically strategic
for multiplication of the Gospel
more than ever before.
Did you know Europe contains less than 3% of committed followers of Jesus Christ? Europe is actually one of the least reached places in the world.
The economic, political, and immigration turmoil across Europe has opened incredible opportunities for people to know the truth and peace of Jesus Christ.
Europe historically has been the influential epicenter for learning, philosophy, art, architecture and religion for more than 2000 years. Now, with the ongoing refugee crisis, reaching Europe is critically strategic for world revival more than ever before.


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We need to start a Pickin in the Park in Monroe, NC. This is how to do it:
Here are links to some of my favorite Old Time Music and Dance Festivals for the Summer:
May, Fiddler's Grove, NC
June, Annual Fiddler's Convention, Mount Airy, NC:
July, usually the week before Clifftop Old Time Music Jam at Tom Phlegar's Farm, near Pembroke, VA. (no website)
August, Appalachian String Band Music Festival, better known as "Clifftop", WV:
August, Galax Old Time Fiddler's Convention:
Old Time Dance and Music- in general, with great links:
And now, closer to my home pickin' and dance parlor, but unfortunately with many broken links (where did they all go?):
Have a nice summer Uncle Mudd!
P.S. We need to get a Home Page on the Internet; so we can compete with neuveau bands like the Reed Island Pickers (trees or music?). Trees can be found at 715 Peacock Dr., Hillsville, VA 24343. Read more at their site: