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Adjusting your backpack
Adjusting your backpack
What do I need to consider when adjusting & fitting my backpack?
Making sure your backpack is properly adjusted can really make a difference. Because the better it is adapted to you personally, the easier you'll find carrying it over a longer period of time.
Adjusting your backpack in six easy steps
How to adjust & position your backpack correctly in six easy steps
1. Loosen off all straps: When trying it on, make sure your backpack is filled with a realistic load weight and loosen off all straps, before shouldering the pack.
2. Position the hip fins: Place the center of the hip fins covering the top of the hip bone and secure the waist belt. Too high, and the belt will restrict the waist, too low and the hip fins will rub on your thighs.
3. Adjust shoulder straps: Finally pull the shoulder straps. But not too tight, because the main load should still be borne by the waist belt.
4. Check the position:: Ideally, the shoulder strap anchor points should be positioned between the shoulder blades. This will ensure the shoulder padding covers the shoulders effectively.
5. Adjust the sternum strap and buckle shut: The sternum strap stabilizes the shoulder straps and is a standard feature on most deuter backpacks. Once you've found the correct back length, the sternum strap can be adjusted up or down, buckled shut and then tightened. Make sure that in doing so, your breathing is not restricted.
6. Stabilizer straps: By tightening the stabilizer straps at the shoulders and on the hip fins, the load is carried closer to your back for greater control.
How to adjust your backpack: stabilizer straps
There are a few things you need to bear in mind when adjusting the stabilizer straps: Doing it right can make your hike easier, but get it wrong, and it can have the opposite effect.
Once your hiking backpack is correctly adjusted, you can pull on the waist belt stabilizer straps to transfer more of the load, or loosen them off for greater freedom of movement depending on the terrain.
With large capacity backpacks you can adjust the stabilizer straps on the shoulder straps: When they're loose, it allows better airflow when moving over easier terrain. Pulled tight, they pull the load closer to the body for greater control when moving over more challenging terrain.
On longer days,loosening or tightening the shoulder straps and stabilizer straps from time to time can shift the load between the hips and the shoulders to alleviate each in turn.
The stabilizer straps are most effective when set at an angle between 30° and 45°.
With deuter's trekking packs the correct angle is achieved by threading it through a higher or lower buckle on the body of the pack.
- With smaller capacity backpacks,and lighter loads, stabilizer straps perform a different function. Here, they can be used to make incremental adjustments to the back length. By loosening or tightening the stabilizer straps and shoulder straps, you can adjust the position of the pack on your back. The angle at which they are set in this case can be much smaller, or even negligible.
then the back length will be too long. The shoulder strap anchor points end up too close together at the neck and the padding on the shoulder straps runs under the armpits, which can lead to chafing on the neck and arms. This also means the load will tilt backwards. And so being able to adjust the length of shoulder straps avoids this.
Even selecting the correct back length will prevent this from happening. Choosing the right back length is critical in ensuring maximum range of movement for the arms and making sure the anatomically S-shaped shoulder padding takes the strain off the neck muscles. So, for smaller backpacks, make sure you select the right size for you (Standard, SL or EL) and for larger packs adjust the back system (VariQuick) correctly.
then the back length will be too short. The padding on the shoulder straps finishes short of where it is required, the straps cut into you and the shoulder straps slip off the shoulders more easily. This is something you should always watch out for when adjusting your deuter backpack.
Using the VariQuick system to adapt the back length of your backpack — in three steps
In addition to adjusting your backpack properly, it's also important to use it properly so that it's comfortable for you to carry while you're hiking, trekking or traveling. Backpack models with an adjustable back length and internal frame should therefore be set to the right length. And remember to always pack your backpack correctly! All of these factors affect the carry comfort. A badly adjusted backpack or back system, cancels out any benefits from a good-quality carry system.
Adjusting the VariQuick system:
- Determine the correct length for your back: If you need help with that, head on over to our choosing the right backpack size advice page.
- Undo the Velcro strap in the middle and pull it out
- The thread it through the 4 loops at the height you've chosen, in an upward direction, and fasten again.
Super-fast precision back length adjustment:
- Lift the plastic buckle in the centre of the back panel.
- At the same time, either raise or lower the shoulder straps to the desired position.
Load, back length & carry comfort: 3 key aspects for adjusting your backpack
For loads above 10 kg, or when walking longer distances in particular, having the right back length is critical to carry comfort. Which is why it's often better for backpacks from 35 liters' capacity and more to be fitted with the VariQuick back length adjustment system. In just a few easy steps, the back length can be adapted to the individual. For smaller capacity packs it's more important to keep the overall weight down. And so for these models, we offer different sizing: Regular, SL, EL. Our backpacks are designed with an average sized athletic person in mind.


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Type: Brawl Stars pencil case/Brawl Stars Cosmetic Cases
Skin: Happymod Brawl Stars
Style: Leon Brawler Stars pencil case with double large pocket and small front pocket
Design: Leon the Chameleon under the Brawl Stars logo with Brawl Stars skulls and stars
Size: 20 x 10 x 7.5 cm
This Brawl Stars pencil case is suitable for: Child, Boy, Girl, Teenager, Adult, Man, Woman
Brawl Stars gift idea: Birthday, Party, Christmas, Reward, Souvenir, Homecoming, Surprise …
Expected Delivery: Production time is 2-5 working days. Estimated delivery time: Shipping Times.
Return Eligibility: Please send back in original packaging, undamaged. Contact our support staff HERE and they will assist you accordingly.

subset: commoncrawl


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[Alanson Sample] and [Joshua R. Smith] have been experimenting with wireless power transfer for their sensing platform. Their microcontroller of choice is the MSP430, which we used on our e-paper clock. They chose it specifically for its ability to work with low voltages and they discus its specific behavior at different voltages. The first portion of their paper uses a UHF RFID reader to transmit to the sensor's four stage charge pump. They added a supercap to provide enough power for 24 hours of logging while the node isn't near a reader. For the second half of the paper, they use a UHF antenna designed for digital TV with the same circuit and pointed it at a television tower ~4.1km away. It had an open circuit voltage of 5.0V and 0.7V across an 8KOhm load, which works out to be 60uW of power. They connected this to the AAA battery terminals of the thermometer/hygrometer pictured above. It worked without issue. The thermometer's draw on a lab power supply was 25uA at 1.5V.
It's an interesting approach to powering devices. Do you have an application that needs something like this? For more on wireless power, checkout this earlier post on scratch building RFID tags.
[via DVICE]


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We're extremely happy with the proactive approach we get from the StreamGuys technical team, which has been a pleasant surprise. We are getting calls and emails about minor glitches that we would have only noticed in the past if listening in real time. Based on the full complement of technology and services we are getting from StreamGuys, we have positioned ourselves for the kind of digital streaming growth and monetization we have wanted to do for years. We're very excited about our streaming future.
The difference with StreamGuys is that they are not forcing us into one business model for streaming services. They instead provide us with the streaming services that are right for our model, and deliver the ongoing recommendations, support and troubleshooting we need. That helps us keep costs low and leaves us to focus on program content and customer relationships — which is what we do best.
We have a strong sense of place and love the music we play. We're passionate about sharing this with the rest of the world, and StreamGuys helped us increase online listenership with the reliability of its global infrastructure.
I have always thought of StreamGuys as more of a partner than just another company I work with. They provide outstanding customer service and a willingness to find solutions to obstacles. StreamGuys has also offered flexible, affordable services to meet my changing bandwidth needs over the years, and they have been receptive and responsive to my requests regarding capabilities of the HTML5 player.
In StreamGuys, we have found an ideal technology partner that understands the same opportunities we see to evolve our radio products. Their infrastructure and technology, along with competitive pricing and expertise in broadcasting, gives us incredible flexibility in the management and delivery of our network-wide streaming initiatives.
More than their technology is the consulting, guidance, troubleshooting and technical support that StreamGuys provides for every event. We would not have the offerings we have today without them. They have created a personalized team for us, with 24/7 availability.
Our online audience has increased more than tenfold since migrating to the StreamGuys platform. StreamGuys remains flexible in pricing, building new and economical streaming packages when applicable to meet our evolving needs.
Our partnership with StreamGuys makes it exceptionally easy for customers to instantly extend their reach through internet streaming. StreamGuys' robust, cloudbased infrastructure meets the high standards for reliability and scalability that our customers demand, while its extensive analytics capabilities bring additional value to our customers. As pioneers and innovators ourselves, we're thrilled to be working with the likeminded experts at StreamGuys.
We wanted the Monterey Jazz Festival stream to resemble a TV special with a professional, multi-camera shoot. We had the venue, the performers, the production team and the media partners, but no one to deliver it to the world. It was important for us to partner with a company like StreamGuys that had the experience.
When AP was looking to create a unique feed of our top news stories, it was a challenge. We wanted breaking news stories continuously inserted into a stream of regular spot-news, with no human curation. StreamGuys were the only ones who understood the concept and constructed an amazing sounding stream quickly and economically. They're always responsive to our day-to-day challenges and are a great partner when we discuss concepts.
StreamGuys built a plan that brings multiple elements at a very affordable price, including my website, archive storage and access, live video streaming bandwidth and administrative aspects.
StreamGuys' willingness to take us on when we were a fledging organization with tiny streaming needs allowed us to get started and grow into an online archive nearly 3,000 items strong.
StreamGuys has proven a reliable partner that has been key to our success. We like to focus our efforts on programming, as well as generating the necessary funding we need to operate our station to its highest potential. We are happy we have the experts at StreamGuys to help us manage the distribution of our online channels.
It was great to be able to count on you guys as this story broke. The stream worked great and your team's response was fantastic.
StreamGuys has supported our needs as a broadcaster for the past several years, and continues to add new services and capacity to grow with us. The establishment of a local point-of-presence confirms their commitment to our business model by helping us keep costs low for our regional online and mobile listeners.
The transition to StreamGuys quickly solved the problems we faced with buffering issues and signal drops across a variety of mobile devices. Additionally, the design of their media player is appealing to listeners and advertisers alike, and offers exceptional value and reliability at a very affordable price point. StreamGuys has been very responsive and proactive in making sure our requirements are exceeded.
StreamGuys is the perfect fit for us--economical, scalable, and best of all, REACHABLE. Got questions? They've got answers--without excuses. Even though we're a small account, we've always been treated in a first-class manner.
StreamGuys developed a strong combination of hardware and streaming infrastructure that covered everything from dynamic user numbers to ad delivery. They built a redundant server backbone to handle thousands of connections seamlessly, with automatic failover to backup systems as needed. It's an intelligent configuration that can determine which server and data center location is best equipped to handle each connection. And the ad insertion service happens entirely server-side, which means we simply have to send a tone down the audio chain to trigger ads. They do all the heavy lifting, which removes the headaches of manual ad management from the client side.


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Sorry, there are no products in this collection
Our Workroom has a collected inventory of pieces waiting for reinvention, revamping and reupholstery!
We may have a furniture item to suit you, why not contact us to discuss what you are searching for.
At Home Industry we offer unique bespoke making services to help you enhance the interior style of your home.
• Soft Furnishings
• Curtains & Blinds
• Upholstery & Slip Covers & more
Call us to discuss your requirements on 02 9818 4529, or email us at firstname.lastname@example.com
Home Industry is a vintage furniture & bespoke soft furnishings store. We offer a unique custom made service to create beautiful, locally handmade homewares and interior products especially for & in consultation with you.
62 Darling Street
Balmain East NSW 2041
Trading Hours
Tuesday to Friday • 10am to 5pm
Saturday • 9 to 2pm
Phone: 02 9818 4529
e: email@example.com
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You are very welcome to the web site for the Parish of Antrim, in the town of Antrim. I hope you find the information helpful and that it gives you some idea about the life of our parish community.
Recently, the Parish of Antrim was formed as a result of the amalgamation of St Comgall's and St Joseph's parishes. For the younger parishioners, a new thing but for the more senior a return to the old, as this had been one parish from 1873 up until 1985. Together, we must build and pray with one another on our journey as a parish community ensuring that everyone is welcomed and respected.
In the parish there is a great awareness of the faith that has been passed from one generation to the next. It is a faith that supports people in their times of struggle and always gives hope but should never be inward looking. Therefore, we welcome the support and prayers of our neighbours from the other Christian traditions and we want to build good and meaningful relationships together and to play our part in the civic life of this town.
Since 1873, many things have changed and there are different challenges for different generations but ultimately for each person, it is always about trying to do the right thing and for the one who believes in Christ, having the courage to trust and believe in the Gospel.
On behalf of the parish team, I welcome your support and interest and pray that the blessing of God is with you.
Sean Emerson
Parish Priest


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27" T x 31" W x 16" D
There are no bids for the lot at this time
Everything is sold "as is, where is" with no guarantees or warranties expressed or implied. You are responsible for inspecting items prior to purchase. ONLINE BIDDING ONLY! There is a 10% BUYERS PREMIUM on all items purchased. BUYER'S PREMIUM is capped at $1000.00 per item. An additional 3% convenience fee will be added on all debit/credit cards. Credit Cards are accepted up to $5000.00. FORMS OF ACCEPTED PAYMENT: Cash, Check w/MN Drivers License, Visa, MasterCard (With 3% Convenience Fee). NO out of state checks. This auction will close 5 items per minute starting at the posted time - Standard overtime bidding rules will apply. AT THE CLOSE OF THE AUCTION ITEMS WILL REMAIN OPEN UNTIL NO BIDS HAVE BEEN RECEIVED FOR THREE (3) MINUTES. THIS MEANS THAT IF AN ITEM RECEIVES A BID IN THE LAST 3 MINUTES, THE CLOCK TO CLOSE THE ITEM WILL RESTART UNTIL NO FURTHER BIDS ARE RECEIVED. THIS IS TO ENSURE THAT NO SNIPING TAKES PLACE. IMPORTANT NOTE: If the high bidder of item does NOT acknowledge their purchase(s), Oberman Auctions reserves the right to determine how and to whom the item(s) will be resold. If we determine the winning bid was not a bona fide, legitimate bidder, the item WILL NOT AUTOMATICALLY go to the next or second highest bid. High bidders will receive an e-mailed invoice by within 1 hour of the auction close. We will also have a copy of the invoice at the removal location.
St. Cloud, Minnesota 56301
United States
Please Do Not Bid If You Can't Pick Up On The Days Listed!
Wednesday, October 12th & Thursday, October 13th from 9:00 am to 6:00 pm.


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Your Trusted SEO Company in Ulhasnagar
We boast a team of highly experienced SEO experts in Ulhasnagar
Increase your website's traffic in 90 days
When you're selecting an SEO company in Ulhasnagar, make sure to choose one that has been around for more than ten years, has a clear plan, can show proven results, has satisfied clients, and communicates well. If these qualities are missing, you'll be wasting your time and money.
At Bigpage, we understand the specific needs of the local area and keep up with the latest trends in the industry. We offer customized solutions that fit within your budget. Our seasoned SEO company in India values open and friendly communication and works together effectively. Start improving your online presence today with Bigpage. In just 90 days, your website can attract more visitors and increase your revenue.
With a large number of happy customers and success stories, Bigpage can assist your website in attracting more visitors and clients. Contact us today for a complimentary consultation. Transform your online presence through SEO.
What we do for our client in SEO:
Keyword research
Integrate relevant keywords into your page
Optimise your page title & meta description
Review competitor's backlinks
Create user friendly content
Optimise images with keywords
Create internal links
Create SEO-friendly URLs
Integrate social links
Build quality backlinks with other website
Find the right customers
Create SEO-friendly footer links
Increase core web vitals score
Optimise URLs
Increase page loading time
Integrate schema markup on the page
Make your web page mobile friendly
Create SEO-friendly navigation and menu structure
Increase page loading time
Core SEO services that we offer to drive relevant traffic and conversion
SEO Keyword Research
SEO keyword research is important for improving the website's visibility in search engine results, attracting relevant visitors, and online presence. Read more
SEO content gap analysis
SEO Content gap analysis empowers businesses to stay competitive, reach a wider audience, and achieve their online goals. Read more
Content creation
We create high-quality, relevant, and engaging content is essential for both users and search engines. Read more
SEO Competitor Analysis
By conducting a regular SEO competitor analysis, you can stay ahead of the competition and improve your website's ranking in search results. Read more
SEO Strategy
A data-driven SEO Strategy can work wonders for your website. It enhances your presence in search engine results, leading to higher CTR. Read more
SEO Site audit
We optimise page titles, meta descriptions, header tags, image alt tags, and internal linking, and ensure that your site has a user-friendly structure and navigation. Read more
Off-page SEO
We include external factors that affect your website's ranking, such as backlinks from other websites, social media signals, and online reviews. Read more
International SEO
Optimising the website for international search engines can expand the audience, and traffic and finally increase revenue. Read more
Our range of SEO packages is flexible and can be tailored to meet your specific needs, market segment, market size, and the number of targeted keywords. Whether you have a particular project in mind, need a customized solution, or require assistance in selecting the most suitable package for your business, don't hesitate to get in touch with our team. You can also schedule a complimentary 30-minute consultation to help you determine the perfect choice for your business.
SEO features |
Basic$250/month (single site) |
Professional$500/month (single site) |
Advanced$1000/month (multisite) |
SEO Site Audit | yes | yes | yes |
Page Experience Audit | yes | yes | yes |
SEO Competitor Analysis | yes | yes | yes |
Local SEO | yes | yes | yes |
SEO Keyword Research | yes | yes | yes |
SEO Strategy | yes | yes | yes |
Analytics and Reporting | no | yes | yes |
Content Optimisation | no | no | yes |
International SEO | no | no | yes |
91 6363 1616
91 6363 1616
SEO Interview questions and answers
Technical question and answer What to do if a page doesn't index? If you found Google isn't indexing your website,...
How to write SEO title & meta description to increase organic traffic
SEO titles and meta descriptions are important factors of keywords ranking over 200+ SEO signals. But we need to write...
Frequently Asked Questions (FAQs) for SEO:
Why do I need SEO?
SEO is important for businesses of all sizes. By improving their SEO, businesses can attract more visitors to their website, which can lead to increased sales and revenue.
What are the benefits of SEO?
There are many benefits to SEO, including:
- Increased website traffic
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What is included in SEO services?
The specific services included in SEO will vary depending on the provider, but typically include:
- Keyword research
- Content optimization
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How long does it take to see results from SEO?
The amount of time it takes to see results from SEO will vary depending on a number of factors, including the competitiveness of the keywords, the quality of the website content, and the amount of effort put into SEO. However, most businesses will start to see results within 3-6 months.
What is the cost of SEO services?
The cost of SEO services will vary depending on the provider and the scope of services offered. However, most businesses can expect to pay between $500 and $5,000 per month for SEO services.


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Turn a Less Than Perfect Home into
Dream Home with a FHA 203K Loan!
About FHA 203K Home Loans
An FHA 203K loan is a loan backed by the federal government and given to buyers who want to renovate a home. An FHA 203K loan allows the borrower to finance the home, plus provides financing to do the necessary renovations to the home.
We're here to make the 203K home loan process easier, with tools and knowledge that will help guide you along the way, starting with our 203K Loan Qualifier.
We'll help you clearly see differences between loan programs, allowing you to choose the right one for you whether you're a first-time home buyer or a repeat buyer.
The 203K Loan Process
Here's how our home loan process works:
- Complete our simple 203K Loan Qualifier
- Receive options based on your unique criteria and scenario
- Compare mortgage interest rates and terms
- Choose the offer that best fits your needs
Fairway is not affiliated with any government agencies. These materials are not from HUD or FHA and were not approved by HUD or a government agency.
Why a FHA 203K Loan?
The main benefit of these loans is that they give you the ability to buy a home in need of repairs that you might not otherwise have been able to afford to buy. Plus, the down payment requirements are minimal, and often you may be able to receive a favorable interest rate.
203K Loan Qualifier


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Navigation |
Multiplexing and demultiplexing video signals and data streams.Multiplexing and demultiplexingMuch of the complexity in a KVM extender's design involves multiplexing and demultiplexing the RGB (separate sync) video and various data streams (PS/2® keyboard/ mouse and serial data) over the four twisted pairs within a CATx cable. The figure below illustrates one of the most common schemes. The red, green and blue (RGB) components of the analogue video signal are multiplexed with the horizontal and vertical sync pulses (polarity maintained) so that all five video components can be transmitted across three of the twisted pairs. The remaining pair is used for a bidirectional data channel onto which keyboard, mouse and serial data are multiplexed in a proprietary format. To maintain signal quality and minimise potential interference between adjacent pairs and externally, all signals are sent differentially. For each video signal, the extender contains a high-bandwidth active balun circuit, while the data channel can use a system such as RS-485 or a Current Loop. |


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Episode-804- Steve Aukstakalnis from Alerts USA and Threat Journal
Podcast: Play in new window | Download (16.0MB)
Today I am joined on The Survival Podcast by Steve Aukstakalnis. Steve is the founder of AlertsUSA, a Miami based risk management firm providing one of the nation's most widely used terrorism and national security threat alert services for mobile devices. He started the firm in late 2001 out of a two bedroom apartment following the attacks of 9/11.
The company now serves a client base that extends to more than 20 countries, from government agencies all the way down to business travelers and the average guy or gal on the street that wants to keep up on breaking events.
His information sources and contacts provide a unique perspective on national and international events and the potential impact here at home. He is with us today to talk about storm clouds building on a number of fronts.
Additional Resources for Today's Show
- Members Support Brigade
- TSP Gear Shop
- Join Our Forum
- Knife Kits – (sponsor of the day)
- Western Botanicals – (sponsor of the day)
Steven's Links
- Alerts USA – Special Link to Get the Special Price MSB Members check your private member's area for an even better deal.
- Threat Journal – Subscribe to Threat Journal for Free and Get Entered Automatically to Win one of Five Nuclear Radiation Safety Packages each includes.
- (1) NukAlert Personal Radiation Monitor and Alarm
- (5) Radsticker Peel and Stick Dosimeters
(1) Box ThyroSafe Potassium Iodide Tablets (65 mg) - These packages are valued around $200 each.
Remember to comment, chime in and tell us your thoughts, this podcast is one man's opinion, not a lecture or sermon. Also please enter our listener appreciation contest and help spread the word about our show. Also remember you can call in your questions and comments to 866-65-THINK and you might hear yourself on the air.


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Music History #12: "Vagabond Ways"
By Bill DeMain
"Vagabond Ways"
Written by Marianne Faithfull and David Courts (1999)
Performed by Marianne Faithfull
The Music
Marianne Faithfull has had many lives—60s-era folk singer, Swinging London swinger, girlfriend of Mick Jagger, and sadly, in the 1970s, drug addict and street person. But in the 80s, she made a comeback, reinventing herself as a jazzy cabaret singer. On the title track of her 1999 album Vagabond Ways, Faithfull was inspired by a news article about the enforced sterilization of undesirables in Sweden. The song was never a chart hit, but it remains a powerful part of Faithfull's live set.
The History
Between 1935 and 1975, over 60,000 people living in Sweden were sterilized against their will. That may come as a shock, especially since Sweden has long been known as a bastion of liberal idealism and sexual freedom.
But in the early part of the 20th century, Sweden fell under the spell of "eugenics," a scientific idea concerned with improving human population by controlled breeding. Or to give it a more chilling phrase: racial hygiene.
The word eugenics was coined by English anthropologist Francis Galton. A cousin of Charles Darwin, Galton had taken a cue from a chapter on variation in breeding in Darwin's Origin of Species. He then devoted his professional life to studying genetics and their effect on behavior and abilities. He believed that breeding within one race between healthy individuals created stronger, more eminent offspring.
In Sweden, two laws were signed regarding eugenics. The first, in 1934, allowed sterilization of the mentally ill and mentally retarded without any legal procedure. In 1941, a second law was enacted, setting forth grounds for sterilization for eugenic, social, or medical reasons. While in theory these laws were meant to prevent the transmission of mental illness, they soon became perverted into a different idea—to prevent the propagation of racially mixed people.
By the early 1940s, that meant that gypsies, vagabonds, deviants and anyone who didn't fit into the Swedish mainstream. Even single mothers were soon obligated to sacrifice their reproductive freedom if they wanted to remain in Sweden. The pressure was severe. It was a case of "Sign this or you'll get no social benefits, no vacation, no apartment. Sign this or we'll take your kids away." Basically, legalized blackmail.
Sweden was not alone in this. Norway, Denmark, and even the United States had their own sterilization programs. And of course, in the twisted hands of Germany's Nazi Party, the eugenics idea was carried to massively tragic ends.
The issue resurfaced in the news in early 2012, when Sweden was criticized for refusing to update a 1972 law that requires all "transgender people to become sterilized before their gender reassignment will be formally recognized by the state." Activist groups are currently fighting to have it overturned.


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As the nation's economy slows, the trucking industry is busier than ever delivering goods and keeping shelves stocked.
But with State Drivers License Agencies closed in more than 20 states, students are stuck in a holding pattern.
"Truck drivers or bus drivers aren't produced overnight; it takes a number of weeks or months to get them trained," said Don Lefeve, President and CEO of the Commercial Vehicle Training Association (CVTA).
In states where DMV's are closed, students can't get their Commercial Learners Permit (CLP), which authorizes them to practice on public roads with a qualified CDL holder in the vehicle. Without a CLP, students are losing out on valuable weeks of on-the-road training.
And those ready to test for their Commercial Drivers License (CDL) are also in limbo.
"That's really problematic for our members and for motor carriers that want to hire new drivers," said Lefeve.
The industry was already short tens of thousands of drivers before the pandemic hit.
"We're going to need new drivers to haul the freight when this crisis is over, because the recovery is actually just as important as the response, or arguably equally as, if not more important," said Lefeve.
At United Truck Driving School in San Diego, five students got their CLP one day before DMV's in the state shut down.
Because Arizona offers third party testing, the school will bus the students over state lines so they can get their CDL.
"This roadblock of no DMV testing, it hits them personally, and we want to do everything we can to get these people out on the road, get them a good-paying job, support their family, and also support America's pipeline of supplies," said Cindy Stullich, director of the school.
No new drivers in various states could eventually lead to shipping delays and higher prices in goods.
Lefeve is urging governors in those states to allow exceptions for these drivers to protect the nation's supply chain.
"I think most Americans don't think too much about truck drivers until time of crisis, and these men and women are doing heroic work," said Lefeve.


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HP is leading the digital transformation of printing and offering its customers exciting new ways to be creative, save money, improve productivity,and stand out. For the home, the office, and graphics markets, HP has a wide range of award-winning products and services to help our customers succeed.
HP offers specialized products for the Government, Education and Health Care marketplaces. Need equipment for a special application chances are HP has a solution for you. Trust Shore Office Systems and HP to provide a solution for your printing needs.


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According to Perry Noble, you "officially suck as a human being" if you express to Perry that you are purposely late to church because you like his preaching but don't care for the music style.
NewSpring members need to be careful that their church doesn't begin to fall into the category of a cult. Cults often begin by having a very demanding, charismatic leader, they will require conformity with rigid extra-biblical rules, they will devalue outsiders and non-conformists, and they will suppress dissent.
You see all four of these beginning to emerge at NewSpring. Not saying they are a cult, but when the charismatic leader starts telling people that :
- they can't come back into the auditorium after the sermon starts even if they leave to tend to a child or go to the bathroom;
- that you suck as a human being if you disagree with the pastor over music styles;
- you are not allowed to designate how your donations are spent;
- you must give 10% of your income to the church undesignated or God will curse you;
- parents cannot bring children younger than 12 years of age into the church services;
- you must show up to church on time or you can't get into the church service;
...then you better begin to get concerned.
Lest you think that I'm overstating things by bringing up the word "cult" - don't forget what happened to a critic of Perry Noble's at the hands of staff members a few years back that is the subject of an on-going lawsuit. You see from the "you suck as a human being" quote how those who even mildly express dissent are devalued by the pastor. I would say it is this kind of rhetoric from the pastor towards dissenters that breeds the actions taken by a staff member against the Noble critic back in 2008 and 2009.
Perry Noble even tells the parents that if they don't conform to the "authority" of the church leaders, they will breed rebelliousness in the hearts of their children . No, actually subjecting one's self to non-biblical requirements for the pleasure of the pastor might teach your kids that they must endure spiritual abuse at the hands of an over-bearing preacher.
Chris is right on in his analysis. This is classic sheep beating. A pastor is to be the picture of humility and servant-hood for the people he shepherds, but instead Perry Noble is a stand-up comedian who makes jokes about troublesome church members, denigrates Christians who disagree with him, and lays down extra-biblical rules that are burdensome on people.
Unfortunately in Perry Noble and other mega pastor superstars these days, we have professional religious men who have turned Christianity from its essence: the release of sinful men and women from the burden of having to try to please God with their works and their alms through simple faith in Christ - into a strict religious system that demands conformity to religious practices, tells people how they must think and what rules they must obey to be pleasing to God and their priest, and uses tactics of guilt and shame in the process. And, oh by the way, they get filthy rich while doing it.
I'm pretty sure that if Jesus were here, he would warn the people of NewSpring about the arrogant Perry Noble and his professional religious men and describe them as he did the Pharisees:


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Tropic of Capricorn to Nadi Airport
- 기간: 10 분
Breeze Through Departure: Private Airport Transfer from Tropic of Capricorn to Nadi Airport with Go Local Fiji
Ensure a smooth and stress-free conclusion to your Fijian adventure with a private airport transfer from Tropic of Capricorn to Nadi International Airport, courtesy of Go Local Fiji, the top-rated transfer and tour company in Fiji.
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Personalized Service:
Unlike crowded shuttles, you'll enjoy the exclusivity and comfort of a private transfer. Your dedicated driver will be waiting for you at the designated pick-up location at Tropic of Capricorn, ready to whisk you directly to Nadi Airport.Warm Fijian Welcome: Go Local Fiji embodies Fijian hospitality. Upon arrival at Tropic of Capricorn, you'll be greeted with a friendly smile and a beautiful shell lei, a traditional Fijian token of welcome.
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Leaving Fiji shouldn't be a hassle. By choosing Go Local Fiji's private transfer service, you can rest assured that you'll arrive at Nadi Airport relaxed and prepared for your onward journey, leaving a lasting positive memory of your Fijian experience.


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Tampa Bay Buccaneers Motorcycle Mat 82.5" L x 42" W
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Manufacturer: Fan Mats
Show off your team pride with Sports Licensing Solutions'' motorcycle mats. You can protect your garage floor from dirt, debris, and oil. Grip-style backing keeps mat in place while catching and holding liquids. Mat is only 5/16" thick!
**Due to recent changes in logos and team locations some of the looks and colors may be different than what is pictured.
This item is made to order and may not be returnable. Please see our Return Policy for details.
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Tampa Bay Buccaneers Motorcycle Mat 82.5" L x 42" W Reviews


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Resilient Biker Shorts 6" - Space Blue, Sage, Rust, Basil, Cool Gray.
Vital Apparel Resilient Biker Shorts features our stunning buttery soft, sweat-wicking, 4 way stretch material leaving you speechless after you try them on. Featuring outstanding durability, non-slip waist, and top of the line stitching. These Shorts can withstand the toughest work outs and keep your mind clear during peaceful yoga sessions.
Size Guide : We're true to size! Please go with the size you normally wear in other brands. We do offer free exchanges! You can also reach out to us with any sizing help.
- Ultra soft polyester/spandex sweat-wicking fabric
- 4 way stretch
- Squat proof
- Reflective Vital Apparel logo
- Non-slip high waist
- Light weight
- 6" Inseam
- Machine wash cold with like color, tumble dry low.
- Do NOT bleach, dry clean, or use fabric softener.


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The Public Works Maintenance Division, which consists of Facilities, Grounds, Fleet, Marina, Streets, and Traffic maintenance sections, provides a wide range of services to the community and is responsible for the repair and maintenance of City-owned property.
Our mission is to provide cost effective, efficient and responsive service to the City of Vallejo and the public.
There are many functions that the Maintenance Division performs on a daily basis. A few of them are:
Engineering City Council Presentation - Street Repair & PCI List
Tree Removal and Tree Trimming Permits and Services
Berth Rental Fees & Payment
Illegal Dumping on Public and Private Property
Temporary Encampment Clean Up
Mare Island Causeway
To report a non-emergency maintenance issue, please use SeeClickFix below.
Don't see what you're looking for? Please call us at (707) 648-5235.
Oscar Alcantar Assistant Public Works Director -Maintenance 111 Amador Street Vallejo, CA 94590
Email Us Phone (707) 649-7701 Fax (707) 648-5203
Julia O'Rourke Maintenance Division Secretary (707) 649-7701
Patrick Hutchinson Assistant Maintenance Superintendent (707) 648-4557
Jorge Pamogas Fleet Manager (707) 648-4334


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Label: INDOMETHACIN capsule
Contains inactivated NDC Code(s)
NDC Code(s): 42254-081-15, 42254-081-21, 42254-081-30 - Packager: Rebel Distributors Corp
- This is a repackaged label.
- Source NDC Code(s): 68462-302
- Category: HUMAN PRESCRIPTION DRUG LABEL
- DEA Schedule: None
- Marketing Status: Abbreviated New Drug Application
Drug Label Information
Updated January 10, 2012
If you are a consumer or patient please visit this version.
- Download DRUG LABEL INFO: PDF XML
- Medication Guide: HTML
- Official Label (Printer Friendly)
- Rx Only
(What is this?)
Cardiovascular Risk
- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS).
- Indomethacin is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
Gastrointestinal Risk
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at a greater risk for serious gastrointestinal events (see WARNINGS).
Indomethacin capsules, USP for oral administration are provided in two dosage strengths which contain either 25 mg or 50 mg of indomethacin. Indomethacin is a non-steroidal anti-inflammatory indole derivative designated chemically as 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H -indole-3-acetic acid.
The structural formula is:
C19H16ClNO4 M.W. 357.79
Indomethacin, USP is practically insoluble in water and sparingly soluble in alcohol. It has a pKa of 4.5 and is stable in neutral or slightly acidic media and decomposes in strong alkali.
Each capsule for oral administration contains 25 mg or 50 mg of indomethacin and the following inactive ingredients: colloidal silicon dioxide, FD&C Blue No. 1, D&C Yellow No. 10, gelatin, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, sodium starch glycolate and titanium dioxide.
The imprinting ink contains the following: black iron oxide, butyl alcohol, dehydrated alcohol, isopropyl alcohol, potassium hydroxide, propylene glycol, shellac, strong ammonia solution and purified water.
Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) that exhibits antipyretic and analgesic properties. Its mode of action, like that of other anti-inflammatory drugs, is not known. However, its therapeutic action is not due to pituitary-adrenal stimulation.
Indomethacin is a potent inhibitor of prostaglandin synthesis in vitro. Concentrations are reached during therapy which have been demonstrated to have an effect in vivo as well. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Moreover, prostaglandins are known to be among the mediators of inflammation. Since indomethacin is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Indomethacin has been shown to be an effective anti-inflammatory agent, appropriate for long-term use in rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.
Indomethacin affords relief of symptoms; it does not alter the progressive course of the underlying disease.
Indomethacin suppresses inflammation in rheumatoid arthritis as demonstrated by relief of pain, and reduction of fever, swelling and tenderness. Improvement in patients treated with indomethacin for rheumatoid arthritis has been demonstrated by a reduction in joint swelling, average number of joints involved, and morning stiffness; by increased mobility as demonstrated by a decrease in walking time; and by improved functional capability as demonstrated by an increase in grip strength. Indomethacin may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. In such instances the steroid dosage should be reduced slowly and the patients followed very closely for any possible adverse effects.
Indomethacin has been reported to diminish basal and CO2 stimulated cerebral blood flow in healthy volunteers following acute oral and intravenous administration. In one study, after one week of treatment with orally administered indomethacin, this effect on basal cerebral blood flow had disappeared. The clinical significance of this effect has not been established.
Indomethacin capsules have been found effective in relieving the pain, reducing the fever, swelling, redness, and tenderness of acute gouty arthritis (see INDICATIONS AND USAGE).
Following single oral doses of indomethacin capsules 25 mg or 50 mg, indomethacin is readily absorbed, attaining peak plasma concentrations of about 1 and 2 mcg/mL, respectively, at about 2 hours. Orally administered indomethacin capsules are virtually 100% bioavailable, with 90% of the dose absorbed within 4 hours. A single 50 mg dose of indomethacin oral suspension was found to be bioequivalent to a 50 mg indomethacin capsule when each was administered with food.
Indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean half-life of indomethacin is estimated to be about 4.5 hours. With a typical therapeutic regimen of 25 mg or 50 mg t.i.d., the steady-state plasma concentrations of indomethacin are an average 1.4 times those following the first dose.
Indomethacin exists in the plasma as the parent drug and its desmethyl, desbenzoyl, and desmethyl-desbenzoyl metabolites, all in the unconjugated form. About 60% of an oral dosage is recovered in urine as drug and metabolites (26% as indomethacin and its glucuronide), and 33% is recovered in feces (1.5% as indomethacin).
About 99% of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. Indomethacin has been found to cross the blood-brain barrier and the placenta.
Carefully consider the potential benefits and risks of indomethacin capsules and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
Indomethacin capsules have been found effective in active stages of the following:
- Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
- Moderate to severe ankylosing spondylitis.
- Moderate to severe osteoarthritis.
- Acute painful shoulder (bursitis and/or tendinitis).
- Acute gouty arthritis.
Indomethacin is contraindicated in patients with known hypersensitivity to indomethacin or the excipients (see DESCRIPTION).
Indomethacin should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic/anaphylactoid reactions to NSAIDs have been reported in such patients (see WARNINGS: Anaphylactic/Anaphylactoid Reactions, and PRECAUTIONS: General: Preexisting Asthma ).
Indomethacin is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
Cardiovascular Effects
Cardiovascular Thrombotic Events
Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. All NSAIDs, both COX-2 selective and nonselective, may have a similar risk. Patients with known CV disease or risk factors for CV disease may be at greater risk. To minimize the potential risk for an adverse CV event in patients treated with an NSAID, the lowest effective dose should be used for the shortest duration possible. Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. Patients should be informed about the signs and/or symptoms of serious CV events and the steps to take if they occur.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The concurrent use of aspirin and an NSAID does increase the risk of serious GI events (see WARNINGS: Gastrointestinal Effects).
Two large, controlled, clinical trials of a COX-2 selective NSAID for the treatment of pain in the first 10 to 14 days following CABG surgery found an increased incidence of myocardial infarction and stroke (see CONTRAINDICATIONS).
NSAIDs, including indomethacin, can lead to onset of new hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. Patients taking thiazides or loop diuretics may have impaired response to these therapies when taking NSAIDs. NSAIDs, including indomethacin, should be used with caution in patients with hypertension. Blood pressure (BP) should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
Congestive Heart Failure and Edema
Fluid retention and edema have been observed in some patients taking NSAIDs. Indomethacin should be used with caution in patients with fluid retention or heart failure.
In a study of patients with severe heart failure and hyponatremia, indomethacin was associated with significant deterioration of circulatory hemodynamics, presumably due to inhibition of prostaglandin dependent compensatory mechanisms.
Gastrointestinal Effects
Risk of Ulceration, Bleeding, and Perforation
NSAIDs, including indomethacin, can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the esophagus, stomach, small intestine, or large intestine, which can be fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs. Only one in five patients, who develop a serious upper GI adverse event on NSAID therapy is symptomatic. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occur in approximately 1% of patients treated for 3 to 6 months, and in about 2 to 4% of patients treated for one year. These trends continue with longer duration of use, increasing the likelihood of developing a serious GI event at some time during the course of therapy. However, even short-term therapy is not without risk.
Rarely, in patients taking indomethacin, intestinal ulceration has been associated with stenosis and obstruction. Gastrointestinal bleeding without obvious ulcer formation and perforation of preexisting sigmoid lesions (diverticulum, carcinoma, etc.) have occurred. Increased abdominal pain in ulcerative colitis patients or the development of ulcerative colitis and regional ileitis have been reported to occur rarely.
NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. Patients with a prior history of peptic ulcer disease and/or gastrointestinal bleeding who use NSAIDs have a greater than 10-fold increased risk for developing a GI bleed compared to patients with neither of these risk factors. Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. Most spontaneous reports of fatal GI events are in elderly or debilitated patients and therefore, special care should be taken in treating this population.
To minimize the potential risk for an adverse GI event in patients treated with an NSAID, the lowest effective dose should be used for the shortest possible duration. Patients and physicians should remain alert for signs and symptoms of GI ulceration and bleeding during NSAID therapy and promptly initiate additional evaluation and treatment if a serious GI adverse event is suspected. This should include discontinuation of the NSAID until a serious GI adverse event is ruled out. For high risk patients, alternate therapies that do not involve NSAIDs should be considered.
Renal Effects
Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a non-steroidal anti-inflammatory drug may cause a dose dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate over renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, patients with volume depletion, and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.
Increases in serum potassium concentration, including hyperkalemia, have been reported with use of indomethacin, even in some patients without renal impairment. In patients with normal renal function, these effects have been attributed to a hyporeninemic-hypoaldosteronism state (see PRECAUTIONS: Drug Interactions).
Advanced Renal Disease
No information is available from controlled clinical studies regarding the use of indomethacin in patients with advanced renal disease. Therefore, treatment with indomethacin is not recommended in these patients with advanced renal disease. If indomethacin therapy must be initiated, close monitoring of the patient's renal function is advisable.
Anaphylactic/Anaphylactoid Reactions
As with other NSAIDs, anaphylactic/anaphylactoid reactions may occur in patients without known prior exposure to indomethacin. Indomethacin should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs (see CONTRAINDICATIONS and PRECAUTIONS: General: Preexisting Asthma ). Emergency help should be sought in cases where an anaphylactic/anaphylactoid reaction occurs.
Skin Reactions
NSAIDs, including indomethacin, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. Patients should be informed about the signs and symptoms of serious skin manifestations and use of the drug should be discontinued at the first appearance of skin rash or any other sign of hypersensitivity.
In late pregnancy, as with other NSAIDs, indomethacin should be avoided because it may cause premature closure of the ductus arteriosus.
Ocular Effects
Corneal deposits and retinal disturbances, including those of the macula, have been observed in some patients who had received prolonged therapy with indomethacin. The prescribing physician should be alert to the possible association between the changes noted and indomethacin. It is advisable to discontinue therapy if such changes are observed. Blurred vision may be a significant symptom and warrants a thorough ophthalmological examination. Since these changes may be asymptomatic, ophthalmologic examination at periodic intervals is desirable in patients where therapy is prolonged.
Central Nervous System Effects
Indomethacin may aggravate depression or other psychiatric disturbances, epilepsy, and parkinsonism, and should be used with considerable caution in patients with these conditions. If severe CNS adverse reactions develop, indomethacin should be discontinued.
Indomethacin may cause drowsiness; therefore, patients should be cautioned about engaging in activities requiring mental alertness and motor coordination, such as driving a car. Indomethacin may also cause headache. Headache which persists despite dosage reduction requires cessation of therapy with indomethacin.
Indomethacin cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. Abrupt discontinuation of corticosteroids may lead to disease exacerbation. Patients on prolonged corticosteroid therapy should have their therapy tapered slowly if a decision is made to discontinue corticosteroids.
The pharmacological activity of indomethacin in reducing fever and inflammation may diminish the utility of these diagnostic signs in detecting complications of presumed noninfectious, painful conditions.
Hepatic Effects
Borderline elevations of one or more liver tests may occur in up to 15% of patients taking NSAIDs, including indomethacin. These laboratory abnormalities may progress, may remain unchanged, or may be transient with continuing therapy. Notable elevations of ALT or AST (approximately three or more times the upper limit of normal) have been reported in approximately 1% of patients in clinical trials with NSAIDs. In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis and hepatic failure, some of them with fatal outcomes have been reported.
A patient with symptoms and/or signs suggesting liver dysfunction, or in whom an abnormal liver test values has occurred, should be evaluated for evidence of the development of a more severe hepatic reaction while on therapy with indomethacin. If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc.), indomethacin should be discontinued.
Hematological Effects
Anemia is sometimes seen in patients receiving NSAIDs, including indomethacin. This may be due to fluid retention, occult or gross GI blood loss, or an incompletely described effect upon erythropoiesis. Patients on long-term treatment with NSAIDs, including indomethacin, should have their hemoglobin or hematocrit checked if they exhibit any signs or symptoms of anemia.
NSAIDs inhibit platelet aggregation and have been shown to prolong bleeding time in some patients. Unlike aspirin, their effect on platelet function is quantitatively less, of shorter duration, and reversible. Patients receiving indomethacin who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants, should be carefully monitored.
Preexisting Asthma
Patients with asthma may have aspirin-sensitive asthma. The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal. Since cross-reactivity, including bronchospasm, between aspirin and other non-steroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, indomethacin should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.
Information for Patients
Patients should be informed of the following information before initiating therapy with an NSAID and periodically during the course of ongoing therapy. Patients should also be encouraged to read the NSAID Medication Guide that accompanies each prescription dispensed.
- Indomethacin, like other NSAIDs, may cause serious CV side effects, such as MI or stroke, which may result in hospitalization and even death. Although serious CV events can occur without warning symptoms, patients should be alert for the signs and symptoms of chest pain, shortness of breath, weakness, slurring of speech, and should ask for medical advice when observing any indicative sign or symptoms. Patients should be apprised of the importance of this follow-up (see WARNINGS: Cardiovascular Effects).
- Indomethacin, like other NSAIDs, can cause GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, which may result in hospitalization and even death. Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative signs or symptoms including epigastric pain, dyspepsia, melena, and hematemesis. Patients should be apprised of the importance of this follow-up (see WARNINGS: Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation).
- Indomethacin, like other NSAIDs, can cause serious skin side effects such as exfoliative dermatitis, SJS, and TEN, which may result in hospitalizations and even death. Although serious skin reactions may occur without warning, patients should be alert for the signs and symptoms of skin rash and blisters, fever, or other signs of hypersensitivity such as itching, and should ask for medical advice when observing any indicative signs or symptoms. Patients should be advised to stop the drug immediately if they develop any type of rash and contact their physicians as soon as possible.
- Patients should promptly report signs or symptoms of unexplained weight gain or edema to their physicians.
- Patients should be informed of the warning signs and symptoms of hepatotoxicity (e.g., nausea, fatigue, lethargy, pruritus, jaundice, right upper quadrant tenderness and "flu-like" symptoms). If these occur, patients should be instructed to stop therapy and seek immediate medical therapy.
- Patients should be informed of the signs of an anaphylactic/anaphylactoid reaction (e.g. difficulty breathing, swelling of the face or throat). If these occur, patients should be instructed to seek immediate emergency help (see WARNINGS).
- In late pregnancy, as with other NSAIDs, indomethacin should be avoided because it may cause premature closure of the ductus arteriosus.
Laboratory Tests
Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding. Patients on long-term treatment with NSAIDs should have their CBC and a chemistry profile checked periodically. If clinical signs and symptoms consistent with liver or renal disease develop, systemic manifestations occur (e.g., eosinophilia, rash, etc.) or if abnormal liver tests persist or worsen, indomethacin should be discontinued.
Drug Interactions
ACE Inhibitors and Angiotensin II Antagonists
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors and angiotensin II antagonists. Indomethacin can reduce the antihypertensive effects of captopril and losartan. These interactions should be given consideration in patients taking NSAIDs concomitantly with ACE inhibitors or angiotensin II antagonists. In some patients with compromised renal function, the coadministration of an NSAID and an ACE inhibitor or an angiotensin II antagonist may result in further deterioration of renal function, including possible acute renal failure, which is usually reversible.
When indomethacin is administered with aspirin, its protein binding is reduced, although the clearance of free indomethacin is not altered. The clinical significance of this interaction is not known.
The use of indomethacin in conjunction with aspirin or other salicylates is not recommended. Controlled clinical studies have shown that the combined use of indomethacin and aspirin does not produce any greater therapeutic effect than the use of indomethacin alone. In a clinical study of the combined use of indomethacin and aspirin, the incidence of gastrointestinal side effects was significantly increased with combined therapy.
In a study in normal volunteers, it was found that chronic concurrent administration of 3.6 g of aspirin per day decreases indomethacin blood levels approximately 20%.
Beta-Adrenoceptor Blocking Agents
Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by non-steroidal anti-inflammatory drugs including indomethacin has been reported. Therefore, when using these blocking agents to treat hypertension, patients should be observed carefully in order to confirm that the desired therapeutic effect has been obtained.
Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin. NSAIDs should be used with caution in patients taking cyclosporine, and renal function should be carefully monitored.
In normal volunteers receiving indomethacin, the administration of diflunisal decreased the renal clearance and significantly increased the plasma levels of indomethacin. In some patients, combined use of indomethacin and diflunisal has been associated with fatal gastrointestinal hemorrhage. Therefore, diflunisal and indomethacin should not be used concomitantly.
Indomethacin given concomitantly with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Therefore, when indomethacin and digoxin are used concomitantly, serum digoxin levels should be closely monitored.
In some patients, the administration of indomethacin can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing, and thiazide diuretics. This response has been attributed to inhibition of renal prostaglandin synthesis.
Indomethacin reduces basal plasma renin activity (PRA), as well as those elevations of PRA induced by furosemide administration, or salt or volume depletion. These facts should be considered when evaluating plasma renin activity in hypertensive patients.
It has been reported that the addition of triamterene to a maintenance schedule of indomethacin resulted in reversible acute renal failure in two of four healthy volunteers. Indomethacin and triamterene should not be administered together.
Indomethacin and potassium-sparing diuretics each may be associated with increased serum potassium levels. The potential effects of indomethacin and potassium-sparing diuretics on potassium kinetics and renal function should be considered when these agents are administered concurrently. Most of the above effects concerning diuretics have been attributed, at least in part, to mechanisms involving inhibition of prostaglandin synthesis by indomethacin.
During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see WARNINGS: Renal Effects), as well as to assure diuretic efficacy.
Indomethacin capsules 50 mg t.i.d. produced a clinically relevant elevation of plasma lithium and reduction in renal lithium clearance in psychiatric patients and normal subjects with steady-state plasma lithium concentrations. This effect has been attributed to inhibition of prostaglandin synthesis. As a consequence, when NSAIDs and lithium are given concomitantly, the patient should be carefully observed for signs of lithium toxicity. (Read circulars for lithium preparations before use of such concomitant therapy). In addition, the frequency of monitoring serum lithium concentration should be increased at the outset of such combination drug treatment.
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
The concomitant use of indomethacin with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.
Oral anticoagulants
Clinical studies have shown that indomethacin does not influence the hypoprothrombinemia produced by anticoagulants. However, when any additional drug, including indomethacin, is added to the treatment of patients on anticoagulant therapy, the patients should be observed for alterations of the prothrombin time. In postmarketing experience, bleeding has been reported in patients on concomitant treatment with anticoagulants and indomethacin. Caution should be exercised when indomethacin and anticoagulants are administered concomitantly. The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
When indomethacin is given to patients receiving probenecid, the plasma levels of indomethacin are likely to be increased. Therefore, a lower total daily dosage of indomethacin may produce a satisfactory therapeutic effect. When increases in the dose of indomethacin are made, they should be made carefully and in small increments.
Drug/Laboratory Test Interactions
False-negative results in the dexamethasone suppression test (DST) in patients being treated with indomethacin have been reported. Thus, results of the DST should be interpreted with caution in these patients.
Carcinogenesis, Mutagenesis, Impairment of Fertility
In an 81-week chronic oral toxicity study in the rat at doses up to 1 mg/kg/day, indomethacin had no tumorigenic effect.
Indomethacin produced no neoplastic or hyperplastic changes related to treatment in carcinogenic studies in the rat (dosing period 73 to 110 weeks) and the mouse (dosing period 62 to 88 weeks) at doses up to 1.5 mg/kg/day.
Indomethacin did not have any mutagenic effect in in vitro bacterial tests (Ames test and E. coli with or without metabolic activation) and a series of in vivo tests including the host-mediated assay, sex-linked recessive lethals in Drosophila , and the micronucleus test in mice.
Indomethacin at dosage levels up to 0.5 mg/kg/day had no effect on fertility in mice in a two generation reproduction study or a two litter reproduction study in rats.
Teratogenic Effects. Pregnancy Category C
Teratogenic studies were conducted in mice and rats at dosages of 0.5, 1, 2, and 4 mg/kg/day. Except for retarded fetal ossification at 4 mg/kg/day considered secondary to the decreased average fetal weights, no increase in fetal malformations was observed as compared with control groups. Other studies in mice reported in the literature using higher doses (5 to 15 mg/kg/day) have described maternal toxicity and death, increased fetal resorptions, and fetal malformations. Comparable studies in rodents using high doses of aspirin have shown similar maternal and fetal effects. However, animal reproduction studies are not always predictive of human response. There are no adequate and well controlled studies in pregnant women.
Indomethacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Nonteratogenic Effects
Because of the known effects of non-steroidal anti-inflammatory drugs on the fetal cardiovascular system (closure of ductus arteriosus), use during pregnancy (particularly late pregnancy) should be avoided.
The known effects of indomethacin and other drugs of this class on the human fetus during the third trimester of pregnancy include: constriction of the ductus arteriosus prenatally, tricuspid incompetence, and pulmonary hypertension; nonclosure of the ductus arteriosus postnatally which may be resistant to medical management; myocardial degenerative changes, platelet dysfunction with resultant bleeding, intracranial bleeding, renal dysfunction or failure, renal injury/dysgenesis which may result in prolonged or permanent renal failure, oligohydramnios, gastrointestinal bleeding or perforation, and increased risk of necrotizing enterocolitis.
In rats and mice, 4 mg/kg/day given during the last 3 days of gestation caused a decrease in maternal weight gain and some maternal and fetal deaths. An increased incidence of neuronal necrosis in the diencephalon in the live born fetuses was observed. At 2 mg/kg/day, no increase in neuronal necrosis was observed as compared to the control groups. Administration of 0.5 or 4 mg/kg/day during the first 3 days of life did not cause an increase in neuronal necrosis at either dose level.
Labor And Delivery
In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystocia, delayed parturition, and decreased pup survival occurred. The effects of indomethacin on labor and delivery in pregnant women are unknown.
Nursing Mothers
Indomethacin is excreted in the milk of lactating mothers. Indomethacin is not recommended for use in nursing mothers.
Pediatric Use
Safety and effectiveness in pediatric patients 14 years of age and younger have not been established.
Indomethacin should not be prescribed for pediatric patients 14 years of age and younger unless toxicity or lack of efficacy associated with other drugs warrants the risk.
In experience with more than 900 pediatric patients reported in the literature or to the manufacturer who were treated with indomethacin capsules, side effects in pediatric patients were comparable to those reported in adults. Experience in pediatric patients has been confined to the use of indomethacin capsules.
If a decision is made to use indomethacin for pediatric patients 2 years of age or older, such patients should be monitored closely and periodic assessment of liver function is recommended. There have been cases of hepatotoxicity reported in pediatric patients with juvenile rheumatoid arthritis, including fatalities. If indomethacin treatment is instituted, a suggested starting dose is 1 to 2 mg/kg/day given in divided doses. Maximum daily dosage should not exceed 3 mg/kg/day or 150 to 200 mg/day, whichever is less. Limited data are available to support the use of a maximum daily dosage of 4 mg/kg/day or 150 to 200 mg/day, whichever is less. As symptoms subside, the total daily dosage should be reduced to the lowest level required to control symptoms, or the drug should be discontinued.
Geriatric Use
As with any NSAID, caution should be exercised in treating the elderly (65 years and older) since advancing age appears to increase the possibility of adverse reactions (see WARNINGS: Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation and DOSAGE AND ADMINISTRATION). Elderly patients seem to tolerate ulceration or bleeding less well than other individuals and many spontaneous reports of fatal GI events are in this population (see WARNINGS: Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation).
Indomethacin may cause confusion or, rarely, psychosis (see ADVERSE REACTIONS); physicians should remain alert to the possibility of such adverse effects in the elderly.
This drug is known to be substantially excreted by the kidney and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection and it may be useful to monitor renal function (see WARNINGS: Renal Effects).
The adverse reactions for indomethacin capsules listed in the following table have been arranged into two groups: (1) incidence greater than 1%; and (2) incidence less than 1%. The incidence for group (1) was obtained from 33 double-blind controlled clinical trials reported in the literature (1,092 patients). The incidence for group (2) was based on reports in clinical trials, in the literature, and on voluntary reports since marketing. The probability of a causal relationship exists between indomethacin and these adverse reactions, some of which have been reported only rarely.
Incidence greater than 1%
nausea1 with or without vomiting
dyspepsia1 (including indigestion, heartburn and epigastric pain)
abdominal distress or pain
constipationCENTRAL NERVOUS SYSTEM
headache (11.7%)
depression and fatigue (including malaise and listlessness)SPECIAL SENSES
none1 Reactions occurring in 3% to 9% of patients treated with indomethacin. (Those reactions occurring in less than 3% of the patients are unmarked.)
Incidence less than 1%
bloating (includes distention)
peptic ulcer
rectal bleeding
single or multiple ulcerations, including perforation and hemorrhage of the esophagus, stomach, duodenum or small and large intestines
intestinal ulceration associated with stenosis and obstruction
gastrointestinal bleeding without obvious ulcer formation and perforation of preexisting sigmoid lesions (diverticulum, carcinoma, etc.) development of ulcerative colitis and regional ileitis
ulcerative stomatitis
toxic hepatitis and jaundice (some fatal cases have been reported)
intestinal strictures (diaphragms)CENTRAL NERVOUS SYSTEM
anxiety (includes nervousness)
muscle weakness
involuntary muscle movements
psychic disturbances including psychotic episodes
mental confusion
aggravation of epilepsy and parkinsonism
peripheral neuropathy
dysarthriaSPECIAL SENSES
ocular-corneal deposits and retinal disturbances, including those of the macula, have been reported in some patients on prolonged therapy with indomethacin
blurred vision
hearing disturbances, deafnessCARDIOVASCULAR
congestive heart failure
chest pain
arrhythmia; palpitationsMETABOLIC
weight gain
fluid retention
flushing or sweating
rash; urticaria
petechiae or ecchymosis
exfoliative dermatitis
erythema nodosum
loss of hair
Stevens-Johnson syndrome
erythema multiforme
toxic epidermal necrolysisHEMATOLOGIC
bone marrow depression
anemia secondary to obvious or occult gastrointestinal bleeding
aplastic anemia
hemolytic anemia
thrombocytopenic purpura
disseminated intravascular coagulationHYPERSENSITIVITY
acute anaphylaxis
acute respiratory distress
rapid fall in blood pressure resembling a shock-like state
pulmonary edema
vaginal bleeding
proteinuria, nephrotic syndrome, interstitial nephritis
BUN elevation
renal insufficiency, including renal failureMISCELLANEOUS
breast changes, including enlargement and tenderness, or gynecomastiaCausal Relationship Unknown
Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, the possibility cannot be excluded. Therefore, these observations are being listed to serve as alerting information to physicians:
Cardiovascular: thrombophlebitis
Hematologic: Although there have been several reports of leukemia, the supporting information is weak.
Genitourinary: urinary frequency
A rare occurrence of fulminant necrotizing fasciitis, particularly in association with Group A β-hemolytic streptococcus, has been described in persons treated with non-steroidal anti-inflammatory agents, including indomethacin, sometimes with fatal outcome (see also PRECAUTIONS: General).
The following symptoms may be observed following overdosage: nausea, vomiting, intense headache, dizziness, mental confusion, disorientation, or lethargy. There have been reports of paresthesias, numbness and convulsions.
Treatment is symptomatic and supportive. The stomach should be emptied as quickly as possible if the ingestion is recent. If vomiting has not occurred spontaneously, the patient should be induced to vomit with syrup of ipecac. If the patient is unable to vomit, gastric lavage should be performed. Once the stomach has been emptied, 25 g or 50 g of activated charcoal may be given. Depending on the condition of the patient, close medical observation and nursing care may be required. The patient should be followed for several days because gastrointestinal ulceration and hemorrhage have been reported as adverse reactions of indomethacin. Use of antacids may be helpful.
The oral LD50 of indomethacin in mice and rats (based on 14 day mortality response) was 50 and 12 mg/kg, respectively.
Carefully consider the potential benefits and risks of indomethacin and other treatment options before deciding to use indomethacin. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
After observing the response to initial therapy with indomethacin, the dose and frequency should be adjusted to suit an individual patient's needs.
Indomethacin is available as 25 mg and 50 mg capsules.
Adverse reactions appear to correlate with the size of the dose of indomethacin in most patients but not all. Therefore, every effort should be made to determine the smallest effective dosage for the individual patient.
Pediatric Use
Indomethacin ordinarily should not be prescribed for pediatric patients 14 years of age and under (see WARNINGS).
Adult Use
Dosage Recommendations for Active Stages of the Following:
- Moderate to severe rheumatoid arthritis including acute flares of chronic disease; moderate to severe ankylosing spondylitis; and moderate to severe osteoarthritis.
Suggested Dosage: Indomethacin capsules 25 mg b.i.d. or t.i.d. If this is well tolerated, increase the daily dosage by 25 mg or by 50 mg, if required by continuing symptoms, at weekly intervals until a satisfactory response is obtained or until a total daily dose of 150 mg to 200 mg is reached. DOSES ABOVE THIS AMOUNT GENERALLY DO NOT INCREASE THE EFFECTIVENESS OF THE DRUG.
In patients who have persistent night pain and/or morning stiffness, the giving of a large portion, up to a maximum of 100 mg, of the total daily dose at bedtime may be helpful in affording relief. The total daily dose should not exceed 200 mg. In acute flares of chronic rheumatoid arthritis, it may be necessary to increase the dosage by 25 mg or, if required, by 50 mg daily.
If minor adverse effects develop as the dosage is increased, reduce the dosage rapidly to a tolerated dose and OBSERVE THE PATIENT CLOSELY.
If severe adverse reactions occur, STOP THE DRUG. After the acute phase of the disease is under control, an attempt to reduce the daily dose should be made repeatedly until the patient is receiving the smallest effective dose or the drug is discontinued.
Careful instructions to, and observations of, the individual patient are essential to the prevention of serious, irreversible, including fatal, adverse reactions.
As advancing years appear to increase the possibility of adverse reactions, indomethacin should be used with greater care in the elderly (see PRECAUTIONS: Geriatric Use). - Acute painful shoulder (bursitis and/or tendinitis).
Initial Dose: 75 mg to 150 mg daily in 3 or 4 divided doses. The drug should be discontinued after the signs and symptoms of inflammation have been controlled for several days. The usual course of therapy is 7 to 14 days. - Acute gouty arthritis.
Suggested Dosage: Indomethacin capsules 50 mg t.i.d. until pain is tolerable. The dose should then be rapidly reduced to complete cessation of the drug. Definite relief of pain has been reported within 2 to 4 hours. Tenderness and heat usually subside in 24 to 36 hours, and swelling gradually disappears in 3 to 5 days.
- Moderate to severe rheumatoid arthritis including acute flares of chronic disease; moderate to severe ankylosing spondylitis; and moderate to severe osteoarthritis.
Indomethacin capsules USP are available containing either 25 mg or 50 mg of indomethacin, USP.
The 50 mg capsule is a size '1' two piece opaque green hard gelatin capsules imprinted with 'G302' on body and 'G' on cap filled with white to off-white granular powder. They are available as follows:
Bottles of 15 capsules NDC 42254-081-15
Bottles of 21 capsules NDC 42254-081-21
Bottles of 30 capsules NDC 42254-081-30
Manufactured by:
Glenmark Generics Ltd.
Colvale-Bardez, Goa 403 513, IndiaManufactured for:
Glenmark Generics Inc., USA
Mahwah, NJ 07430Questions? 1 (888)721-7115
www.glenmarkgenerics.comJune 2009
Repackaged by:
Rebel Distributors Corp
Thousand Oaks, CA 91320
Medication Guide for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)(See the end of this Medication Guide for a list of prescription NSAID medicines.)
What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases:
- with longer use of NSAID medicines.
- in people who have heart disease.
NSAID medicines should never be used right before or after a heart surgery called a "coronary artery bypass graft (CABG)."
NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:
- can happen without warning symptoms
- may cause death
The chance of a person getting an ulcer or bleeding increases with:
- taking medicines called "corticosteroids" and "anticoagulants"
- longer use
- smoking
- drinking alcohol
- older age
- having poor health
NSAID medicines should only be used:
- exactly as prescribed
- at the lowest dose possible for your treatment
- for the shortest time needed
What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) ?
NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as:
- different types of arthritis
- menstrual cramps and other types of short-term pain
Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID) ?
Do not take an NSAID medicine:
- if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
- for pain right before or after heart bypass surgery
Tell your healthcare provider:
- about all of your medical conditions.
- about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist.
- if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy.
- if you are breastfeeding. Talk to your doctor.
What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
Serious side effects include:
- heart attack
- stroke
- high blood pressure
- heart failure from body swelling (fluid retention)
- kidney problems including kidney failure
- bleeding and ulcers in the stomach and intestine
- low red blood cells (anemia)
- life threatening skin reactions
- life-threatening allergic reactions
- liver problems including liver failure
- asthma attacks in people who have asthma
Other side effects include:
- stomach pain
- constipation
- diarrhea
- gas
- heartburn
- nausea
- vomiting
- dizziness
Get emergency help right away if you have any of the following symptoms:
- shortness of breath or trouble breathing
- chest pain
- weakness in one part or side of your body
- slurred speech
- swelling of the face or throat
Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:
- nausea
- more tired or weaker than usual
- itching
- your skin or eyes look yellow
- stomach pain
- flu-like symptoms
- vomit blood
- there is blood in your bowel movement or it is black and sticky like tar
- unusual weight gain
- skin rash or blisters with fever
- swelling of the arms and legs, hands and feet
These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or Glenmark Generics Inc., USA at 1 (888)721-7115.
Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
- Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.
- Some of these NSAID medicines are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.
NSAID medicines that need a prescription *Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain. The OTC NSAID label warns that long term continuous use may increase the risk of heart attack or stroke. Generic Name Tradename Celecoxib Celebrex Diclofenac Cataflam, Voltaren, Arthrotec (combined with misoprostol) Diflunisal Dolobid Etodolac Lodine, Lodine XL Fenoprofen Nalfon, Nalfon 200 Flurbiprofen Ansaid Ibuprofen Motrin, Tab-Profen, Vicoprofen* (combined with hydrocodone), Combunox (combined with oxycodone) Indomethacin Indocin, Indocin SR, Indo-Lemmon, Indomethagan Ketoprofen Oruvail Ketorolac Toradol Mefenamic Acid Ponstel Meloxicam Mobic Nabumetone Relafen Naproxen Naprosyn, Anaprox, Anaprox DS, EC-Naprosyn, Naprelan, Naprapac (copackaged with lansoprazole) Oxaprozin Daypro Piroxicam Feldene Sulindac Clinoril Tolmetin Tolectin, Tolectin DS, Tolectin 600 This Medication Guide has been approved by the U.S. Food and Drug Administration.
Manufactured by:
Glenmark Generics Ltd.
Colvale-Bardez, Goa 403 513, IndiaManufactured for:
Glenmark Generics Inc., USA
Mahwah, NJ 07430Questions? 1 (888)721-7115
www.glenmarkgenerics.comJune 2009
Repackaged by:
Rebel Distributors Corp
Thousand Oaks, CA 91320
- Principal Display Panel
indomethacin capsuleProduct Information Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:42254-081(NDC:68462-302) Route of Administration ORAL Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength INDOMETHACIN (UNII: XXE1CET956) (INDOMETHACIN - UNII:XXE1CET956) INDOMETHACIN 50 mg Inactive Ingredients Ingredient Name Strength SILICON DIOXIDE (UNII: ETJ7Z6XBU4) FD&C BLUE NO. 1 (UNII: H3R47K3TBD) LACTOSE MONOHYDRATE (UNII: EWQ57Q8I5X) MAGNESIUM STEARATE (UNII: 70097M6I30) CELLULOSE, MICROCRYSTALLINE (UNII: OP1R32D61U) FERROSOFERRIC OXIDE (UNII: XM0M87F357) BUTYL ALCOHOL (UNII: 8PJ61P6TS3) ALCOHOL (UNII: 3K9958V90M) ISOPROPYL ALCOHOL (UNII: ND2M416302) POTASSIUM HYDROXIDE (UNII: WZH3C48M4T) PROPYLENE GLYCOL (UNII: 6DC9Q167V3) SHELLAC (UNII: 46N107B71O) AMMONIA (UNII: 5138Q19F1X) TITANIUM DIOXIDE (UNII: 15FIX9V2JP) WATER (UNII: 059QF0KO0R) SODIUM LAURYL SULFATE (UNII: 368GB5141J) GELATIN (UNII: 2G86QN327L) D&C YELLOW NO. 10 (UNII: 35SW5USQ3G) Product Characteristics Color GREEN Score no score Shape CAPSULE Size 19mm Flavor Imprint Code G302;G Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:42254-081-30 30 in 1 BOTTLE 2 NDC:42254-081-21 21 in 1 BOTTLE 3 NDC:42254-081-15 15 in 1 BOTTLE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date ANDA ANDA091276 12/22/2010 Labeler - Rebel Distributors Corp (118802834) Registrant - PSS World Medical, Inc. (101822862) Establishment Name Address ID/FEI Business Operations PSS World Medical, Inc. 791528623 REPACK(42254-081) Establishment Name Address ID/FEI Business Operations STAT RX USA LLC 786036330 REPACK(42254-081) Establishment Name Address ID/FEI Business Operations Dispensing Solutions, Inc. 066070785 RELABEL(42254-081) , REPACK(42254-081) Establishment Name Address ID/FEI Business Operations SCRIPT PAK 964420108 RELABEL(42254-081) , REPACK(42254-081) Establishment Name Address ID/FEI Business Operations Keltman Pharmaceuticals, Inc. 362861077 REPACK(42254-081) Establishment Name Address ID/FEI Business Operations Rebel Distirbutors Corp. 118802834 RELABEL(42254-081) , REPACK(42254-081)


text:
B.C. hockey moms were agonizing about how to show support for the Humboldt Broncos and chanced upon a campaign that will help young people channel their grief.
"We said we've got to do something," said Jennifer Pinch.
She and other local hockey moms brainstormed and came up with a hockey jersey campaign for schools on April 12. They posted information Saturday morning, and by Saturday evening it had morphed into a campaign to have anyone wear any type of sports jersey on Thursday to show support for Humboldt and the Broncos.
People are being asked to social media their photos in jerseys, and her group is coming up with a hashtag to add to social media posts.
Pinch said the crash has hit so close to home for Canadians. In her case, her kids are in sports, and her son is just about the age to play at the junior level. A friend of her daughter's was set to try out for the Broncos next week.
"I can literally see it happening to my family," she said of the bus crash.
She said thousands of young people each day board buses to head to competitions and events, and thankfully most arrive home safe and sound, but in this case, a large group of young, talented people didn't.
Several schools have already voiced support for jersey day. The campaign is gaining momentum. There's been media coverage in Africa and the U.S. People have said they will dig out their jerseys in the Comox Valley, Roanoke, Virginia, Ottawa, and beyond.
And some people without jerseys say they will wear Broncos colours that day – gold and green.


text:
Behold! The Fantastic Athletes Who Play Soccer
Soccer is an impossible sport to master -- especially for morons like these fellas.
So which was worse? The goalie who took a banana peal slip off the ball or the opposing player who missed a net open wider than a teen girl on prom night?