text:
There are lots of great things to do on the Internet but, you also need to know how to stay safe online and what to do if you come across something you don't like. Click on our Digital Citizenship Contract to read the Academy rules for responsible IT use.
Links for Children
There are lots of great things to do on the Internet but, you also need to know how to stay safe online and what to do if you come across something you don't like.
- Think U Know for 5 to 7 year olds – 5, 6 or 7? This website has been set up just for you, to help you go on the internet in a safe way and know who to talk to if you are worried.
- Think U Know for 8 to 10 year olds – showing you what's good, look at what's not and show you ways you can get yourself out of bad situations.
- Kids Smart – gives advice on how to stay safe on the Internet, whatever you are doing including searching for information, playing games, listening to music and entering competitions.
- CBBC Stay Safe: Advice on Internet Safety – includes interactive clips from Tracy Beaker, a Newsround Special and Dongle's Guide to be SMART.
Links for Parents and Carers
Using the internet can make learning fun, fast and easy. The following sites offer help to keeping you and your child safe online:
- BBC Webwise online safety course – this site gives advice on not only keeping your child safe, but also gives tips on what adults should be doing for themselves too.
- Think U Know – Parents and Carers – produced by the Child Exploitation and Online Protection Centre (CEOP). Their site offers really good advice on keeping your child safe online.
- DirectGov Internet Safety – offering advice on Cyberbullying, Social Netwroking, downloading files and online gaming as well as general advice on keeping your child safe online.
- Are you a switched on Parent? – click to find out!
- Keep them safe – free online course to help parents to protect their children against sexual exploitation


text:
I had a craving for mushroom soup, so Wild About Mushroom Soup came about. I didn't want a thick gloppy soup but a nice lighter one. I have also made this one gluten-free so it has a nice light feel to it. No heavy cream to weigh it down either.
I love mushroom soup and have my whole life. I love the pairing of mushroom and tarragon and have always added a little to even the canned soup. I think it is a great combination. Not overwhelming but just enough that you can taste it. I hope you enjoy this lightened up version of a cream of mushroom soup. Enjoy!!
Wild About Mushroom Soup
- 1 onion diced
- 1 cup baby carrots sliced
- 2 celery sticks diced
- 2 Tbsp. butter divided
- 2 Tbsp. olive oil divided
- 7 oz. Crimini mushroom sliced
- 7 oz. white mushroom sliced
- 14 gm. package dried wild mushroom mix
- 1 Tbsp. tarragon chopped
- 900 ml. chicken stock or vegetable stock
- 2-3 Tbsp. cornstarch
- 1 cup 1/2 and 1/2 cream or 3% milk
- Salt and pepper to taste
- Soak the dried mushrooms in 1 cup warm water for 20 min. Meanwhile over medium heat saute the onion, carrots, and celery in a large pot in 1 Tbsp. butter and 1Tbsp. olive oil until tender. Salt and pepper to taste. Remove from pan and set aside.
- Heat the remaining butter and olive oil in the saute pan and turn up the heat to medium-high. Saute the mushrooms and tarragon until just tender. Salt and pepper to taste.
- Drain the dried mushroom through a sieve to catch any grit and reserve the liquid. Chop the mushroom up finely And add them to the pot.
- Add the onion mixture back into the pot. Add the chicken stock and the reserved mushroom liquid. Bring to boil and simmer for 30 min. Adjust seasoning. With some of the hot liquid stir it into the cornstarch to make a loose paste. Whisk it into the soup. Add the cream or milk and heat through and serve.

subset: commoncrawl


text:
B.A.T.M.A.N. Advanced Documentation Overview¶
- Table of contents
- B.A.T.M.A.N. Advanced Documentation Overview
How to get a mesh network up and running, how to configure the many features of B.A.T.M.A.N. Advanced, and how to shoot down your troubles.
Getting started¶
- B.A.T.M.A.N. Advanced overview - information about the Layer 2 version of B.A.T.M.A.N.
- Building B.A.T.M.A.N. Advanced with OpenWRT - how to download and configure your OpenWRT build environment to compile batman-adv.
- B.A.T.M.A.N. Advanced quick start guide - or: what the hell is bat0 for?
- Features of batctl - A quick introduction to batctl.
- batctl online man page - read the current batctl man page online
- Wireless Kernel Tweaking - introduction to batman-advanced by Marek and Simon [December 2007] (also available at c3tv)
- Frequently asked questions - A list of frequently asked questions and answers.
Miscellaneous Features
- Translation table in a nutshell - The inner workings of the non-mesh client integration revealed.
- Bridge loop avoidance - Document explaining the bridge loop avoidance implemented in batman-adv.
- AP Isolation - How to prevent wifi-client to wifi-client communication.
- Layer 2 fragmentation - basic concept behind the layer2 fragmentation (GSoC final report)
- Alfred - Use alfred to send local information or visualize your mesh network
Link-Forwarding Optimizations
- Multi-Link Optimizations - how to optimize traffic by using multiple links
- Network Coding - Combine two packets into a single transmission to save air time.
Broadcast & Multicast
- Broadcasts in B.A.T.M.A.N. Advanced - An overview of broadcast/multicast support
- DHCP Gateway Optimization - How batman-adv can be used to choose the nearest internet gateway node.
- Distributed ARP Table - How batman-adv can speed up your mesh experience by caching ARP replies.
- Multicast Optimizations - multicast optimizations overview
- Available Information - Read about the information exported by the module.
- Troubleshooting FAQ - What if my batman-adv setup does not behave as expected ?
Developer Information / Advanced Features¶
- Tweaking the B.A.T.M.A.N. Advanced behaviour - get an overview about the various settings batman-adv offers
- B.A.T.M.A.N. user space events - batman-adv's uevent documentation
- Using the batman git repos - this page explains how the git repository is structured and how to use it
- TVLV - details regarding the TVLV (type-version-length-value) API and defined TVLV containers
Protocol Documentation¶
- B.A.T.M.A.N. Concept - get an overview about B.A.T.M.A.N.'s main concepts
- Routing scenarios - a collection of routing scenarios a routing protocol should be able to handle
- Multi-Link Optimizations - Use multiple links in batman-adv for fun and profit (technical documentation)
- Client announcement - how batman-adv handles non-mesh clients bridged into the mesh
- Client roaming - non-mesh clients moving from one mesh node to the next
- TT Flags - explanation for internal flags used by the translation table code
- Batman-adv packet types - backward compatibility for batman-adv
- Compat versions - packet versions / formats used by batman-adv
- B.A.T.M.A.N. IV - enhanced TQ algorithm
- B.A.T.M.A.N. V - throughput based mesh routing with B.A.T.M.A.N. V
- Bridge-loop-avoidance-II - bridge loop avoidance to allow multiple gateways between LAN and mesh, redesigned
- Distributed ARP Table - technical details regarding the inner working of the DAT mechanism
- Fragmentation - technical details explaining the layer2 fragmentation
- Multicast optimizations - technical details concerning the multicast optimizations
- Network Coding - technical details regarding the network coding implementation
- Batman-adv multicast optimization - how batman-adv optimizes multicast traffic by Linus and Simon [March 2011]
- Bisect the batman-adv routing protocol - the bisect tool explained & demonstrated by Marek [March 2011]
- Project CATWOMAN - network coding with batman-adv - introduction into network coding with batman-adv by Martin and Jeppe [March 2011]
- Random Linear Coding - presentation on network coding by Martin [April 2013]
Who uses B.A.T.M.A.N. Advanced?¶


text:
Gorgeous "Haku" design on Black Adult T-Shirt. Shaka icon on back right ribcage. 6 oz. 100% Cotton Tubular Jersey. High quality double-needle stitching on bottom hem and sleeves. Shoulder-to-shoulder tape. Preshrunk to minimize shrinkage.
Specs: Body Width: S=18", M=20", L=22", XL=24", 2XL=26", 3XL=28".
Care Info:
- Machine wash cold with like colors.
- Only non-chlorine bleach when needed.
- Tumble dry low.
- Do not iron if decorated.


text:
When I found out the winner of our first contest was pregnant, I couldn't resist making her some of my favorite homemade belly butter in addition to her prize of a wedge of homemade Humbolt Fog-inspired cheese. I made up this recipe for stretch mark preventing belly butter when I was pregnant. I used it daily and credit it for sailing through pregnancy without a single stretch mark. Like my Iced Red Raspberry Leaf Tea Recipe (another natural pregnancy remedy) I have been wanting to share it for some time and figured this was a great excuse for sharing it without fear of triggering pregnancy rumors in my extended family.
Researching stretch marks, I learned that the biggest risk factor is genetics. Since my mother did not escape her pregnancies unmarked, I was extra motivated to try to prevent them. The second biggest factor is simply dry skin. This formula uses all natural ingredients, many of them food grade, to nourish, feed and hydrate the skin. I believe this allowed my skin to expand as needed and bounce back better afterwards. I am sensitive to artificial perfumes, and was all the more so during pregnancy, and I had an aversion to the smell of all the stretch mark creams that were commercially made. Like all mothers, I wanted my growing babe to have the best start, so turning to natural ingredients, instead of rubbing chemicals into my bump, was a no-brainer. You could easily add a drop or two of essential oils to add a scent, but I preferred the butter as is, smelling like chocolate and coconut–yum.
- 2 Tablespoons Coconut Oil
- 2 Tablespoons Cocoa Butter
- 2 Tablespoons Shea Butter
- 1 Tablespoon Avocado Oil
- (optional) a few drops of Vitamin E Oil (break open a vitamin capsule for best results)
- (optional) a few drops of essential oil for fragrance
The butter will most likely stay a solid at room temperature (unless the room temperature is very hot, i.e. over 80-85° F). Melt a small amount by rubbing it between your hands and massage into the belly (and anywhere growing). The butter is most easily absorbed by damp skin, so after a shower is ideal. Use at least once a day and more often as needed when skin is starting to feel tight or itchy. Although the vitamin E can help preserve the shelf life, I prefer to make small batches frequently. (This amount usually lasted me two weeks.)
If you do not have one of the ingredients, other options to substitute in include Olive Oil or Argan Oil. You may notice that your finished product is more solid or less solid depending on the products you use and the brands you use. One tip is to keep in mind the relative hardness of the oils/butters. Here's what I have found, listed from firmest to runniest: Cocoa Butter, Shea Butter, Coconut Oil, Vitamin E, Avocado Oil. Don't ever add water to your mix to make it runnier as this can speed up molding, but add a little more Avocado Oil or Olive Oil if you would like it softer. Conversely, if you want it harder, use a little more Cocoa or Shea Butter. Feel free to experiment!
About the Ingredients:
Coconut Oil has fatty chain acids that work to regenerate and rebuild the connective tissues that cause stretch marks. Massaged daily into the skin, it can help keep the skin on a growing belly supple and flexible. Purchase unrefined coconut oil as it has more of the healthful properties (it also smells more "coconuty").
Cocoa Butter contains natural antioxidants and is one of the most stable fats. Although a recent double blind study did not find it better than placebo in preventing stretch marks, it was found to be moisturizing and soothing and daily use prevents dry, itchy skin. Depending on the brand, it can smell quite like chocolate.
Shea Butter originates in Africa and has been used for ages for all kinds of skin care concerns, including dermatitis, eczema, psoriasis, burns and stretch marks. Shea butter enhances the skin's natural barrier function, increases the moisture levels, and helps with cell regeneration. It also helps with capillary circulation, helps sooth irritated skin, helps protect against UV rays and helps with restructuring effects on the epidermis. Try to purchase it unrefined.
Avocado Oil is my new favorite cooking oil. It can be used up to 500° F, as opposed to olive oil, which really shouldn't be heated above 325° F, or it scorches and coverts to trans fats. Avocado has a mild, neutral taste, making it a great replacement for vegetable oil. Used topically on the body, avocado oil is wonderful for moisturizing and is rich in vitamins, fatty acids and antioxidants, including vitamin E.
Vitamin E is a very powerful antioxidant that prevents the formation of free-radical particles. Free radicals break down skin cells and create aging and depletion of nutrients. Vitamin E is known as a natural scar remedy when massaged into the skin. It stimulates the collagen in the skin, which can provide a noticeable difference when it comes to texture and strength. The antioxidant also promotes cell growth and is also a natural anti-inflammatory. Although not a preservative, vitamin E, as an antioxidant, can also help prolong the shelf-life of the belly butter.
When you purchase a qualifying item from Amazon through a link or ad on our page we receive a small percentage. Your price is never increased, in fact, you automatically get the lowest price available at the time. If you like the Baby Birds Farm and Cocina blog, then purchasing through our "Store" page or through a link is a great way to support us! We have strict control over which products we feature, typically use them ourselves and hope you will enjoy them. We are also happy to add items upon request. Thank you!


text:
"We take photographs, as a return ticket to the moment that was otherwise gone". For anyone who wants to linger on a moment for long, there are lessons you can take for photography in Princeton. You can enroll yourself into one of the photography workshops in Princeton and get to master the art. Once you learn this, you can exhibit them or turn this learning to a professional business. There is a lot to learn in terms of techniques and otherwise which you can, through the long list of classes, workshops and photography courses.
Keep an eye on all the upcoming photography events in Princeton here!
Don't miss your favorite Photography Events again.


text:
Merck Serono granted option for exclusive license from Opexa to develop and commercialize Tcelna (imilecleucel-T), an investigational T-cell therapy for patients suffering from multiple sclerosis (MS)
THE WOODLANDS, TEXAS - February 5, 2022 – Opexa Therapeutics, Inc. (NASDAQ: OPXA) today announced the execution of an agreement with Merck Serono, a division of Merck, Darmstadt, Germany, for the development and commercialization of Tcelna™ (imilecleucel-T), a potential first-in-class personalized T-cell therapy for patients suffering from multiple sclerosis (MS). Tcelna (imilecleucel-T) is being developed by Opexa and currently is in a Phase IIb clinical trial in patients with Secondary Progressive MS (SPMS). Potential payments to Opexa from the option and license agreement could total $225 million based upon the successful development and commercialization of Tcelna for MS.
Tcelna (imilecleucel-T) is being developed as a personalized therapy specifically tailored to each patient's individual disease profile and has been evaluated in Phase I and II clinical studies in MS that included SPMS patients. Tcelna (imilecleucel-T) has received Fast Track Designation from the United States Food and Drug Administration as a potential treatment for SPMS.
Under the terms of the agreement, Opexa will receive an upfront payment of $5 million for granting an option to Merck Serono for the exclusive license of the Tcelna (imilecleucel-T) program for the treatment of MS. The option may be exercised prior to or upon completion of Opexa's ongoing Phase IIb clinical trial in patients with SPMS. Upon exercising this licensing option, Merck Serono would pay an upfront license fee of either $25 million or $15 million (depending upon whether certain conditions are met), and in return receive worldwide development and commercial rights to Tcelna (imilecleucel-T) in MS, excluding Japan. After exercising the option Merck Serono would be wholly responsible for funding clinical development, subject to Opexa's co-funding option, as well as regulatory and commercialization activities for the MS program. Additional financial considerations of the agreement include development and commercial milestone payments to Opexa of up to $195 million and a tiered royalty rate from the high single digits to the mid-teens based on net sales payable to Opexa. The potential payments to Opexa could, therefore, total $225 million excluding royalty payments.
Under the agreement, Opexa will have an option right to co-fund development, under which the Company would participate in economic support for future clinical development of the program in exchange for additional royalty consideration. In addition to retaining all rights outside of MS as well as retaining the ability to commercialize Tcelna (imilecleucel-T) in Japan, Opexa also retains certain manufacturing rights related to the program. Further details of the transaction are included in a Form 8-K that was filed this morning by Opexa with the United States Securities and Exchange Commission.
"Merck Serono is strongly committed to developing innovative drug candidates like Tcelna (imilecleucel-T), a potential first-in-class personalized cell therapy for patients with multiple sclerosis," said Susan Herbert, Head of Global Business Development and Strategy at Merck Serono. "This agreement illustrates Merck Serono's commitment to employ creative ways of accessing external innovation to develop potential next generation multiple sclerosis treatments, especially in secondary progressive multiple sclerosis, an area of high unmet need."
Neil K. Warma, President and Chief Executive Officer of Opexa, commented, "Opexa is pleased to partner with Merck Serono and given Merck Serono's long-term strategic commitment to, and existing franchise position in the field of multiple sclerosis, we could not ask for a more experienced partner to carry Tcelna (imilecleucel-T) through development and hopefully to the market and to patients. We also are pleased to retain important rights through this transaction, such as certain manufacturing rights, commercialization rights to the Japanese market and a co-funding of development option, as well as rights for all indications outside of MS, all of which are intended to enhance Opexa shareholder value."
Conference Call
The management of Opexa will host a conference call today, Tuesday, February 5, 2013, at 8:30 a.m. EST to discuss the agreement. To participate in the live conference call, please dial (877) 372-0867 (U.S.) or (253) 237-1170 (International). A live webcast of the call will also be available on the investor relations section of the Company's website, www.opexatherapeutics.com. An online archive of the webcast will be available on Opexa's website for one year following the call.
About Multiple Sclerosis (MS)
MS is a chronic, inflammatory condition of the central nervous system and is the most common, non-traumatic, disabling neurological disease in young adults. It is estimated that approximately two million people have MS worldwide.
While symptoms can vary, the most common symptoms of MS include blurred vision, numbness or tingling in the limbs and problems with strength and coordination. The relapsing forms of MS are the most common.
About Tcelna (imilecleucel-T)
Tcelna (imilecleucel-T) is a potential personalized therapy that is under development to be specifically tailored to each patient's disease profile. Tcelna (imilecleucel-T) is manufactured using ImmPath™, Opexa's proprietary method for the production of a patient-specific T-cell immunotherapy, which encompasses the collection of blood from the MS patient, isolation of peripheral blood mononuclear cells, generation of an autologous pool of myelin-reactive T-cells (MRTCs) raised against selected peptides from myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG) and proteolipid protein (PLP), and the return of these expanded, irradiated T-cells back to the patient. These attenuated T-cells are reintroduced into the patient via subcutaneous injection to trigger a therapeutic immune system response.
Opexa is currently conducting a Phase IIb study of Tcelna (imilecleucel-T). Named Abili-T, the trial is a randomized, double-blind, placebo-controlled clinical study in patients who demonstrate evidence of disease progression without associated relapses. The trial is expected to enroll 180 patients at approximately 30 leading clinical sites in the U.S. and Canada with each patient receiving two annual courses of Tcelna (imilecleucel-T) treatment consisting of five subcutaneous injections per year. The trial's primary efficacy outcome is the percentage of brain volume change (atrophy) at 24 months. Study investigators will also measure several important secondary outcomes commonly associated with MS, including disease progression as measured by the Expanded Disability Status Scale (EDSS), annualized relapse rate and changes in disability as measured by EDSS and the MS Functional Composite.
About Opexa
Opexa Therapeutics, Inc. (NASDAQ:OPXA) is dedicated to the development of patient-specific cellular therapies for the treatment of autoimmune diseases such as MS. The Company's leading therapy candidate, Tcelna™ (imilecleucel-T), is a personalized cellular immunotherapy that is in Phase IIb clinical development for MS. Tcelna (imilecleucel-T) is derived from T-cells isolated from peripheral blood, expanded ex vivo, and reintroduced into the patients via subcutaneous injections. This process triggers a potent immune response against specific subsets of autoreactive T-cells known to attack myelin.
For more information visit the Opexa Therapeutics website at opexatherapeutics.com
About Merck Serono
Merck Serono is the biopharmaceutical division of Merck. With headquarters in Darmstadt, Germany, Merck Serono offers leading brands in 150 countries to help patients with cancer, multiple sclerosis, infertility, endocrine and metabolic disorders as well as cardiovascular diseases. In the United States and Canada, EMD Serono operates as a separately incorporated subsidiary of Merck Serono.
Merck Serono discovers, develops, manufactures and markets prescription medicines of both chemical and biological origin in specialist indications. We have an enduring commitment to deliver novel therapies in our core focus areas of oncology, neurology and immunology.
For more information, please visit www.merckserono.com or www.merckgroup.com
About Merck
Merck is a global pharmaceutical and chemical company with total revenues of €10.3 billion in 2011, a history that began in 1668, and a future shaped by approx. 40,000 employees in 67 countries. Its success is characterized by innovations from entrepreneurial employees. Merck's operating activities come under the umbrella of Merck KGaA, in which the Merck family holds an approximately 70% interest and free shareholders own the remaining approximately 30%. In 1917 the U.S. subsidiary Merck & Co. was expropriated and has been an independent company ever since.
Cautionary Statement Relating to Forward-Looking Information for the Purpose of "Safe Harbor" Provisions of the Private Securities Litigation Reform Act of 1995
This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words "expects," "believes," "may," "could," and similar expressions are intended to identify forward-looking statements. The forward-looking statements in this release do not constitute guarantees of future performance. Investors are cautioned that statements in this press release which are not strictly historical statements, including, without limitation, statements regarding the development of the Company's product candidate, Tcelna (imilecleucel-T), constitute forward-looking statements. Such forward-looking statements are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated, including, without limitation, risks associated with: the success of our clinical trials (including the Phase IIb trial for Tcelna (imilecleucel-T) in SPMS which, depending upon results, may determine whether Merck Serono elects to exercise its option pursuant to the option and development agreement), whether Merck Serono exercises its option and, if so, whether the Company receives any development or commercialization milestone payments or royalties from Merck Serono pursuant to the option and development agreement, our dependence (if Merck Serono exercises its option) on the resources and abilities of Merck Serono for the further development of Tcelna (imilecleucel-T), our ability to raise additional capital to continue our development programs (including to undertake and complete any ongoing or further clinical studies for Tcelna (imilecleucel-T)), the efficacy of Tcelna (imilecleucel-T) for any particular indication, such as for relapsing remitting MS or secondary progressive MS, our compliance with all Food and Drug Administration regulations, our ability to obtain, maintain and protect intellectual property rights (including for Tcelna), and other risks detailed in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date made. We assume no obligation or undertaking to update any forward-looking statements to reflect any changes in expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based. You should, however, review additional disclosures we make in our reports filed with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the year ended December 31, 2021 and our Quarterly Report on Form 10-Q for the quarter ended September 30, 2012.


text:
Down There Press
For many years the focus of fear and disgust, the anus is actually one of the human body's most wondrous creations – elegant, efficient, and richly supplied with pleasure nerves. However, stress and ignorance can turn the anus and its functions from a source of delight into a painful disability. What's needed is an owner's manual – and here it is! Join therapist and sexologist Jack Morin, PhD on this tour of the anus, complete with information and exercises to open the door to new sources of comfort and gratification. You'll unlearn habits that can cause everything from hemorrhoids to chronic pelvic pain – and, if you choose, learn new ways of achieving solo and partnered pleasures through this humblest of portals.


text:
Breadcrumb Home News Broad Institute awarded first patent for engineered CRISPR-Cas9 system By Broad Communications April 15, 2014 CRISPR in action The Broad Institute today announced that the United States Patent and Trademark Office has issued the first patent for an engineered CRISPR-Cas9 system that is enabling scientists to modify genes and better understand the biology of living cells and organisms. The institute applied for the patent in concert with the January 3, 2013 publication in Science (Cong, et al.) that described the use of the CRISPR enzyme, Cas9, for genome editing. Originally discovered in bacteria, where several different CRISPR cascades function as innate immune systems and natural defense mechanisms, the engineered CRISPR-Cas9 system can be programmed to target specific stretches of genetic code and to make cuts at precise locations. Over the past few years, those capabilities have been harnessed and used as genome editing tools, enabling researchers to permanently modify genes in mammalian cells. In the future, these tools may make it possible to correct mutations at precise locations in the three billion-letter sequence of the human genome to treat genetic causes of disease in patients. U.S. Patent No. 8,697,359 is assigned to the Broad Institute and the Massachusetts Institute of Technology and includes claims to the engineered CRISPR-Cas9 system and methods of using the system. "The CRISPR-Cas9 system is an extraordinary, powerful tool. The ability to edit a genome makes it possible to discover the biological mechanisms underlying human biology and, potentially, to treat certain human diseases," said Eric Lander, Broad Institute director. "Consistent with the Broad's mission to accelerate the understanding and treatment of disease, we are committed to empowering the global research community by making this technology broadly available to scientists for research around the world." The Cas9 enzyme can easily be matched with "guide" RNA (gRNA) sequences that lead them to their DNA targets. Tens of thousands of such gRNA sequences have already been engineered. The engineered CRISPR-Cas9 system can also be used to target multiple genes at the same time, which is another advantage that sets the technology apart from other gene-editing tools. "Cas9 is revolutionizing the field of genome editing," said Feng Zhang, Broad core member and inventor. Zhang is also the senior author of the 2013 Science paper showing that Cas9 can be harnessed to modify DNA in mammalian cells. "This is a technology that offers an exciting degree of precision and opens the door to the development of therapeutic tools that can be used to treat genetic disorders." Zhang is also the W. M. Keck Career Development Professor in Biomedical Engineering at MIT, an investigator at the McGovern Institute for Brain Research, and a co-founder of Editas Medicine. About the engineered CRISPR-Cas9 system CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) have recently been harnessed as genome editing tools in a wide range of species. The engineered CRISPR-Cas9 system allows researchers to mutate or change the expression of genes in living cells, including those of humans. The family of Cas9 nucleases (also known as Cas5, Csn1, or Csx12) recognizes DNA targets in complex with RNA guides. Researchers can now harness the engineered system to home in on specific nucleic acid sequences and cut the DNA at those precise targets. The cuts modify the activity of the targeted genes, allowing researchers to study the genes' function. About the Broad Institute of MIT and Harvard The Eli and Edythe L. Broad Institute of MIT and Harvard was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods, and data openly to the entire scientific community. Founded by MIT, Harvard, and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide. For further information about the Broad Institute, go to http://www.broadinstitute.org. Papers cited: Cong L et al. "Multiplex genome engineering using CRISPR/Cas systems" Science. Online January 3, 2013. DOI: 10.1126/science.1231143 Related Genome engineering gets CRISPR (2013) CRISPR system scales up in human cells (2013) Broad, MIT researchers reveal structure of key CRISPR complex (2014) US Patents of Broad Institute Information about licensing CRISPR-Cas9 systems Latest news News 07.17.2024 De-risking drug discovery with predictive AI News 07.11.2024 Targeted drug treatment leads tumor cells to imitate viral infection News 07.10.2024 Prime editing efficiently corrects cystic fibrosis mutation in human lung cells News 07.08.2024 Brain chimeroids offer window into relationships between genetics and exposures All news
Related Genome engineering gets CRISPR (2013) CRISPR system scales up in human cells (2013) Broad, MIT researchers reveal structure of key CRISPR complex (2014) US Patents of Broad Institute Information about licensing CRISPR-Cas9 systems


text:
My Medicine Blog
While medicine is the art of healing, the word medicinal refers to any substance which aids in that art. Many things can have medicinal properties, from pharmaceuticals produce artificially in labs by companies, to natural substances whose healing secrets have been passed down through generations within cultures. Even many common foods can have medicinal properties, such as the well-known medicine of chicken soup.
The development of new medications is big business in the United States and throughout the world. The discipline of medicinal chemistry is an intersection of several hard sciences, chemistry, pharmacology and biology. An understanding of all of these fields is crucial in order to develop new medicines for complex illnesses and conditions that will be of optimum benefit and producing the least negative side effects.


text:
Pennacchio to Jada Pinkett Smith: I love the fact that every year, you support the industry and walk this carpet.?
Pennacchio to Paul Giamatti, Best Supporting Actor nominee for Cinderella Man:? People love your work.?
Thats the last thing he gets to uncork, as the network red-carpet special begins now, meaning Pennacchio turns the buffoon baton over to Billy Bush.


text:
The List of Lists Begins: Best Children's Books of 2009
October 29, 2009
Last year I started compiling all the year-end "best of" lists in newspapers, magaziness, and other sources. I added in many of the various children's literature prizes throughout the year, too. (You can peruse "The Best of the Best: Kids' Books '08" right here.) A person who chooses titles from these lists will read—and give and recommend to children—many good books.
In the process, I discovered that there is no such thing as awards season. Children's books are honored and feted throughout the year from the Newberys and Caldecotts in January to the Cybils in February to the American Horticultural Society/Junior Master Gardeners' "Growing Good Kids" in July to the Children's Book Council of Australia's Books of the Year in August. I'll admit to a soft spot for March's National Science Teachers Association's Outstanding Science Trade Books for Students K-12. Those are books I would have loved as a kid. I tried to be comprehensive, but I know that I missed some lists and prizes.
It's time to start the roundup for books published in 2009. I hear that School Library Journal is working away on its "best of," as we speak. The magazine's Twitter update said recently,"SLJ Best Books update: Not much I can say yet - they're working on it. 'But is it a BEST book?' is the primary debate."
The first two entries for Chicken Spaghetti's "Best Children's Books of 2009: The List of Lists" are the finalists for the National Book Award in "young people's literature" and the long list for the Amercican Association for the Advancement of Science Prizes for Excellence in Science Books for children (currently linked to School Library Journal until the AAAS puts it up on its own site).
I'll keep the big list under Pages, to the right, across from the chicken portrait at the top.


text:
Entice customers to sign up for your mailing list with discounts or exclusive offers. Include an image for extra impact.
Astoria Chrome Slipper Cup. Fit to wooden furniture legs. Slipper cups, also known as leg caps, provide a stylish alternative to brass castors. Use instead of castors on legs for furniture, sofas, tables, chairs and beds. This is a quality manufactured brass leg cap with a sleek design. Widely used throughout the furniture industry by furniture manufacturers, upholsterers and interior designers. Sold individually. Full dimensions for the slipper cups are at the bottom of this page. Height 48mm.
The slipper cups or leg caps are used with furniture legs to create stylish embellishments. A popular alternative to castors, and often used on the back, to match with furniture castors on the front of chairs and sofas. A standard wood screw is included free with each cup, so all you need is a screwdriver to securely fit them to furniture legs through a recessed hole at the bottom of the cup. The screw cannot be seen when fitted.


text:
U.S. Olympic Team Flag
U.S. Olympic Team Flag
Regular price
Regular price
Sale price
Unit price
- 3' x 5'
- Made in U.S.A.
- Polyester
- White Header & (2) Metal Grommets
Shipping & Returns
Shipping & Returns
Shipping Info
Please allow 7 to 10 days for delivery on some of the International & Historic flags as well as some Specialty & State flags.
Most orders will ship within 1 business day. Orders received after 3pm will be shipped the next business day.
Most orders will ship via USPS Priority.
**We do not ship to destinations outside the United States.
You may return any item for any reason within 30 days of receipt for a refund, exchange, or credit. During the holidays, items purchased between November 1st and December 31st can be returned until January 31st. Shipping, handling, and all other fees are not refundable.
Please contact us immediately if your item did not arrive in perfect condition or if we sent you the wrong item.


text:
No Results Found
We couldn't find anything matching your search criteria. Use the following search capabilities to search the John R. Green Co. catalog.
Know the items you need?
Click here to add an item to your order, if you have the five-digit John R. Green Co. merchandise code/item number.
Click here to put in up to ten items at a time.


text:
No Way Up
No Way Up
Watch No Way Up Full Movie Online. Characters from different backgrounds are thrown together when the plane they're travelling on crashes into the Pacific Ocean. A nightmare fight for survival ensues with the air supply running out and dangers creeping in from all sides.
- Genre: Thriller, Horror, Action
- Country: United Kingdom
- Director: Claudio Fäh
- Cast: Colm Meaney, Phyllis Logan, Sophie McIntosh, Will Attenborough, Jeremias Amoore, Manuel Pacific, Grace Nettle, James Carroll Jordan, David J Biscoe, David Samartin, Scott Coker, Lee Byford,


text: Hi. I'm trying to directly integrate the Teensy 4.0 into my PCB. But I'm running into issues finding the capacitors i need for the MIMXRT1062DVL6A supporting circuitry. And I was wondering why all the caps on the Teensy 4.0 schematic are electrolytic. Because I cant find any electrolytic caps for certain values like 10nF. So is there a way I can use standard non polarized capacitors? Because I can find non electrolytic capacitors for all of the values just not electrolytic ones. Or does anybody know where I can get these capacitors in an SMD format?


text:
Although I use a HC-06 in the below examples the HC-05 in slave mode can also be used.
Using MITs app inventor it is fairly easy to create an app that can turn a LED on and off from an Android device.
This is a fairly simply example of sending commands to the Arduino to turn a LED either on or off. The Android app sends ascii codes to the Arduino via the HC-06 BT module; "ON" for on and "OF" for off.
Load the app, connect to the HC-06 and then use the LED button to turn the LED on and off.
You can also open the serial monitor to see the commands as they are received
The steps involved are:
1. create a circuit that includes a Bluetooth module and a LED
2. create an Arduino sketch that can receive commands from the HC-06 and turn a LED on and off
3. create an Android app that sends commands over Bluetooth
The circuit
The circuit is the same as the one used in Arduino and HC-06 (ZS-040) except the addition of a LED + resistor connected to pin D12. I used a 220 ohm resistor because that is what I had to hand but similar values will be OK.
Based on ohm's law; using a source of 5V, a green LED with a forward voltage drop of 2.2v and a forward current of 20mA a 150 ohm resistor is recommended. So any value from 180ohm to around 680 ohms will be OK.
Arduino Sketch
The sketch receives data from the Bluetooth module via software serial. It then checks the data for "ON" and "OF" commands. When "ON" is received the LED is turned on and when "OF" is received the LED is turned off.
To ensure that data is received correctly the data is surrounded by start and end markers. This example uses "<" and ">". I use the function recvWithStartEndMarkers which was posted on the Arduino forum by Robin2. I simply copied the function and did not need to change it.
The recvWithStartEndMarkers() function takes at the data received from the serial connection and copies anything it finds between the start and end markers to the receivedChars variable. When it has found something it sets the newData variable to true.
In the main loop we keep calling the recvWithStartEndMarkers() function until newData has been set. When newData is True we know we have a new command so we call parseData() to deal with it. Inside parseData() we reset newData to false and the process continues.
void loop() { if (BTserial.available() > 0) { recvWithStartEndMarkers(); } if (newData) { parseData(); } } |
The full sketch:
// Bluetooth sketch HC-06_02 // Turn a LED on and off from an Android app // App can be downloaded from www.martyncurrey.com // // Pins // 2 Software serial - RX // 3 Software serial - TX // 12 LED boolean debug = true; #include <SoftwareSerial.h> SoftwareSerial BTserial(2,3); // RX | TX // Connect the HC-06 TX to the Arduino RX. // Connect the HC-06 RX to the Arduino TX through a voltage divider. // max length of command is 20 chrs const byte numChars = 20; char receivedChars[numChars]; boolean newData = false; byte LEDpin = 12; void setup() { pinMode(LEDpin, OUTPUT); Serial.begin(9600); Serial.println("<Arduino is ready>"); // The default baud rate for the HC-06s I have is 9600. Other modules may have a different speed. 38400 is common. BTserial.begin(9600); } void loop() { if (BTserial.available() > 0) { recvWithStartEndMarkers(); } if (newData) { parseData(); } } void parseData() { newData = false; if (debug) { Serial.println( receivedChars ); } if (receivedChars[0] == 'O' && receivedChars[1] == 'N' ) { digitalWrite(LEDpin,HIGH); } if (receivedChars[0] == 'O' && receivedChars[1] == 'F' ) { digitalWrite(LEDpin,LOW); } } void recvWithStartEndMarkers() { // function recvWithStartEndMarkers by Robin2 of the Arduino forums // See http://forum.arduino.cc/index.php?topic=288234.0 static boolean recvInProgress = false; static byte ndx = 0; char startMarker = '<'; char endMarker = '>'; char rc; if (BTserial.available() > 0) { rc = BTserial.read(); if (recvInProgress == true) { if (rc != endMarker) { receivedChars[ndx] = rc; ndx++; if (ndx >= numChars) { ndx = numChars - 1; } } else { receivedChars[ndx] = '\0'; // terminate the string recvInProgress = false; ndx = 0; newData = true; } } else if (rc == startMarker) { recvInProgress = true; } } } |
Android App
I created the Android app in MITs app inventor. This was fairly easy once I had figured out how to use Bluetooth.
The app is very basic, it simply sends commands. There are no checks to see if the Arduino has actually received the commands or not. The screen is also very simple; it has a button for connecting to Bluetooth and a on/off button to control the LED. The app uses a ListPicker to store the available Bluetooth devices which is not displayed on screen. It is initiated from the connect button.
The app has 4 blocks and a list:
Block 1
This handles the connect button. When the button is clicked the block/function first checks to see if Bluetooth is enabled and then checks to see if there is already a Bluetooth connection. If Bluetooth is not turned on an error message is displayed. If there is already an active connection the user is asked if they would like to close it. The user reply is handled in Block3, Notifier1.AfterChoosing
If Bluetooth is on and there isn't a current connection the paired Bluetooth devices are copied to the Bluetooth pairedDevices List. If the list has at least 1 item the contents of the list are copied to the ListPicker. The ListPicker is then activated to allow the user to select a Bluetooth device. I use the pairedDevices list so that I can count the number paired devices. I could not find a way of doing this when using just a ListPicker. If the list is empty an error message is displayed saying there are no paired devices.
Block 2
Block 2, BT_LP.AfterPicking handles the List Picker after the user has selected one of the paired Bluetooth devices. It takes the selected item and tries to connect. If successful the text on the Bluetooth button is changed to "Connected". If a connection cannot be established an error message is displayed.
Once a connection is established the app waits for the LED button to be pressed.
Block 3
Block 3 handles a Notifier dialogue that asks the user if they wish to close the connection
Block 4
Block 4, LED_BUTTON_btn.Click, handles the LED button. By checking the button text we can determine what command to send. If the text says "ON" then the LED is on and we need to turn it off so we send an "OF" command. If the text says "OFF", the LED is off so we send an "ON" command to turn it on. The actual commands are "<ON>" and "<OF>". The button text and background colour are updated to reflect the new LED status.
An error message is displayed if the LED button is clicked and there is no active connection.
In part 2 we add 2-way communication and the facility to control the LED from the Arduino as well as the app.
Add an auto-connect function to an App Inventor app. https://www.martyncurrey.com/android-mit-app-inventor-auto-connect-to-bluetooth/


text:
5 Things you can do locally
Why go local?
Eating locally benefits the environment, your health, farmers and your community...
Find out more-
Adam Hills Comedian
Spicks & SpecksI am a moron. Seriously, a moron. My forefathers would be ashamed of me. Oh sure I can tweet such world-changing thoughts as what my breakfast consisted of, or shoot zombies for hours on end on a simulated computer game - but put me in a garden and ask me to fend for myself and I'm like a puppy in an electronics store. Fascinated but ultimately hopeless. More from Adam
Jackie French Children's author
Earth Garden ColumnistLocal food, or food grown with love or cooked with pride and idealism, doesn't just keep you alive; it keeps you in contact with the earth, the seasons, and your community. It creates a web of friendship. Most of all, perhaps, it makes you deeply happy - sharing food, loving how it tastes, every mouthful with a story of fulfilment behind it. More from Jackie
Jerry Coleby-Williams Organic gardener
Director - Seed Savers NetworkI encourage people to convert streets and parks to permaculture, and to develop intensive organic food production at home. Since the passing of Peak Oil, strategies like these support Australian food sovereignty - and climate repair - in a Warming World. More from Jerry


text:
June 21, 1964 The KKK kills three civil rights activists
Michael Schwerner, Andrew Goodman, and James Chaney are killed by a Ku Klux Klan lynch mob near Meridian, Mississippi. The three young civil rights workers were working to register black voters in Mississippi, thus inspiring the ire of the local Klan. The deaths of Schwerner and Goodman, white Northerners and members of the Congress of Racial Equality (CORE), caused a national outrage.
When the desegregation movement encountered resistance in the early 1960s, CORE set up an interracial team to ride buses into the Deep South to help protest. These so-called Freedom Riders were viciously attacked in May 1961 when the first two buses arrived in Alabama. One bus was firebombed; the other boarded by KKK members who beat the activists inside. The Alabama police provided no protection.
Still, the Freedom Riders were not dissuaded and they continued to come into Alabama and Mississippi. Michael Schwerner was a particularly dedicated activist who lived in Mississippi while he assisted blacks to vote. Sam Bowers, the local Klan's Imperial Wizard, decided that Schwerner was a bad influence, and had to be killed.
When Schwerner, Goodman, and Chaney, a young black man, were coming back from a trip to Philadelphia, Mississippi, deputy sheriff Cecil Price, who was also a Klan member, pulled them over for speeding. He then held them in custody while other KKK members prepared for their murder. Eventually released, the three activists were later chased down in their car and cornered in a secluded spot in the woods where they were shot and then buried in graves that had been prepared in advance.
When news of their disappearance got out, the FBI converged on Mississippi to investigate. With the help of an informant, agents learned about the Klan's involvement and found the bodies. Since Mississippi refused to prosecute the assailants in state court, the federal government charged 18 men with conspiracy to violate the civil rights of Schwerner, Goodman, and Chaney.
Bowers, Price, and five other men were convicted; eight were acquitted; and the all-white jury deadlocked on the other three defendants. On the forty-first anniversary of the three murders, June 21, 2005, Edgar Ray Killen was found guilty of three counts of manslaughter. The 80-year-old Killen, known as an outspoken white supremacist and part-time Baptist minister, was sentenced to 60 years in prison.


text:
During the first day of the
LinuxWorld Expo,
Hancom Linux and
theKompany.com became the talk of the show with the news that they are merging their product lines
and releasing a complete Linux/KDE office suite this coming
November. Dubbed
2.0", the suite will combine 4 Hancom products
(Word, a word processor, Sheet, a spreadsheet, Presenter, a
presentation program, and Painter, a bitmap drawing program) with
4 theKompany.com products (EasyDB, a personal database management
system familiar to us as
Envision, a diagram and flowchart drawing tool familiar to us as
the KOffice component
WebBuilder, an HTML/PHP editing tool familiar to us as
Quanta+, and QuickSilver,
a personal information manager familiar to us as
The Word/Sheet/Presenter applications are advertised as outstanding
at both importing and exporting the corresponding MS Office formats. Because it uses Qt 3.0 the same
boxed set will run on Linux, Mac OS X, Windows and -- yes --
even embedded devices (some planned devices were announced).
Although the products are pure Qt, with 3.0's new features they should
integrate nicely into the KDE desktop.
Suggested retail price: $99. Ready or
not, KDE is coming to Main Street!
Hancom has had these products out for a while already. I think at least for a couple years.
One cannot trademark the use of the word "Word" as it's been in existance since the birth of the English language; and throughout history has been applied to more uses than you can shake a stick at.
You're getting over paranoid.
HancomOffice is installable and executable stably based on the Red Hat and Red Hat compatible Linux distributions such as RedHat 7.0/7.1, Mandrake Linux 7.0/8.0, SuSE Linux 7.0.
Libraries: same as libraries in the Red Hat and the compatible libraries
RPM: the latest 4.0.2 rpm version or previous rpm
/me hmmmz ... Redhat 7.0/7.1 and Mandrake 8.0 are using gcc-2.96 and this ABI is NOT compatible with gcc-2.95 or gcc-3.0. Problems ...
What happened to ftp.kde.org, I just can't get there it always asks for authorization and also I can't login as an anonymous user
Probably overloaded. Use mirrors.
Let me take an opportunity to try and answer all the questions at once, so this might be a rather long email.
1. it is "Rekall" and not "ReKall" :)
2. All theKompany products will continue to exist in the stand alone form.
3. We will continue to maintain Kivio in KOffice. Waldo Bastian and I had a nice chat around the end of LinuxWorld on the topic and I think he understands what we are doing.
4. Since Kivio is the only application currently in KOffice that is affected by this, it doesn't have any major impact.
5. We will statically link Qt3 to the application. We are doing this with DataArchitect currently, and with Kivio MP in our labs. Works great, barely adds any size and doesn't mess with your system.
6. I had about 3 days to come up with new names for theKompany products for the show, some I like, some I don't - consider them code names for now.
7. Hancom can call their application HancomWord because it is MicrosoftWord. This is a common way to avoid trademark problems in the US to put your company name in front of the application.
8. We had never decided to put Rekall into KOffice, and now that it will be Qt only it will never be in KOffice. If you think about it, there isn't really an advantage to embedding a database app inside a KWord document.
9. The current HancomOffice applications have been around for 10 years, they are very mature. Hancom has a very large number of programmers as well. HancomWord has run on Linux under Wine until now, the Qt port is almost complete and will be part of HancomOffice 2.0
10. theKompany holds the license on all of the applications we are using. In the case of Kivio and Quanta, these have gone through a total rewrite in any case to turn them into Qt specific apps.
11. Apparently Quanta development has been stalled for some time. I wasn't aware of this fact when the programmers asked us to take it on. I had been using them as contractors for work and they are great programmers, but I guess they had to make some money so couldn't work on Quanta. In any case we have hired them as employees now. I'm not sure if there will be a free version of Quanta, we've talked about it but just haven't had any time to figure it out yet.
12. Yes that is Kivio running on WinXP. Using Qt it is a very easy matter to make the application run on different platforms.
13. I really am impressed with the work that has gone into KOffice over the years, but you have to be realistic about it. There is only a couple of people working on it part time. KOffice is so far behind HancomOffice it will never catch up. That isn't to say that KOffice isn't what some people will want or need. KDE is interested in the desktop more than the office space, they want to see applications that people will use on the desktop. Our focus on Linux is always going to be advocates for KDE and making sure our Qt apps behave and interact properly under KDE. All of our materials at the LinuxWorld show talked about KDE on Linux.
14. I'm running HancomOffice on a 200Mhz machine at home. I'm not sure why the requirements are listed so large.
15. HancomOffice has an enormous amount of clipart, like 900 pieces, which contributes to its size. As stand alone applications they aren't that large.
16. The MS filters are Hancom intellectual property and are very unlikely to be given away. They do an *excellent* job of import *and* export of MS file formats. I was very impressed.
17. Kparts can't be used because of the cross platform nature, so we will sadly be building a lightweight in-process OLE type model on Qt3 to support embedding (sorry if I got some of that wrong, I don't code much anymore).
18. There is work to do on some of theKompany applications to get ready and now we have the needed resources to accelerate their work. We should hit our November release target.
19. Since we will be statically linked to Qt3 there aren't going to be any distribution specific problems.
Let me say in closing that the interest at LinuxWorld was nothing short of astounding. We had virtually every major player want to partner with us, people wanting to put it in their companies. I had to do 5 interviews while I was there after our press release. The booth was busy the entire time, really busy, which couldn't be said for a lot of the booths. We had people up to the final minutes. There is a tremendous amount of excitment over this. As you all know, I stay involved in these talkbacks and in emails. I'll be glad to answer questions if you have them.
Not everything can be free "as in beer" forever. If there is no money to be made in Linux, no one will be interested in developing software for it, outside of open-source enthusiasts...and let's face it, realistically how much work can one get done while working part-time on a project?
Simply put, there is not enough open-source programmers to fulfill ALL the needs of Linux, so there will be niches here and there where commercial companies can fill in.
The only issue in this matter that theKompany might hit is the status of Kivio (seems like the free Koffice version will still be maintained) and the demise of free Quanta might cause some bad publicity as well...but if the Hancom suite is really so good, well then let it be....plus someone can always take the last GPL-ed version of Quanta and fork it.
The bottom line is that it runs on both Mac, Linux and Windows. If it achieves some reasonable penetration on Windows, then moving people to Linux later on becomes much less of an issue, since they can keep their fav office suite.
So, I guess in the long run, things might even out..
Regardless of how things turn out, kudos to Shawn for pulling a real rabbit out of a hat.
I wanted to buy MS Office for my wife but at $450 Cdn I said "forget it" and got here the beta build of OpenOffice for her spreadsheet and she's quite happy with it. MS software is just so overpriced, that it has a real soft underbelly to it...hit it with a lower price and equal features and compatibility and this could have some success on Windows...with an obvious spillover for Linux as well...
i wish you all the best with your newfound home at Hancom, Shawn (and all the other theKompany devs, too)
i think that there currently is room for a quality commercial office suite in the linux market place. many require such a product for work, and are therefore willing to pay for it.
this marks the end of the "pat on the back" part of my message =) i do take issue with two statements you make in your 19 point posting, Shawn:
10. "In the case of Kivio and Quanta, these have gone through a total rewrite in any case to turn them into Qt specific apps."
For Kivio I really don't think it matters as all the work was obviously sponsered by theKompany, but I would be highly surprised if it was true that Quanta was completely rewritten from scratch. A derivitive work is a derivitive work, even if the result is a very different code base. This doesn't matter if everyone who contributed to Quanta was cool with the switch in license (or their code was removed and replaced, e.g. that part regressed to a CVS patch where their code didn't exist and new code written on that). The claim that it was totally rewritten seems a little .. dubious. even if it is fine because all the developers agreed to the licensing change, there is no reason to misrepresent, right?
13. "I really am impressed with the work that has gone into KOffice over the years, but you have to be realistic about it. There is only a couple of people working on it part time. KOffice is so far behind HancomOffice it will never catch up."
this may have been true before, but i've noticed a marked change in pace. the koffice email list used to be very quiet. progress was slow, but steady. these days there is a lot of development discussion and many more developers working on the various applications. the two that are getting the most attention are kword and kpresenter, and they show it. the graphics apps and kspread have recently gained attention as well.
be careful when you say an open source project "will never catch up". often times that is all they need for inspiration.
honestly, i think point #13 is wishful thinking. Hancom office will have a window in which it will be better, but that window will not exist forever since the end goal is a well known set of features, not a quickly moving target. Unless, of course, Hancom starts inventing completely new office suite technologies.
WRT to Quanta. It is being rewritten, and the two developers are on our staff and are the full license holders.
I'm on the koffice devel lists too, and there is work going on, this is true, but when you are doing something in your spare time, it is usually done in fits and starts for as long as it interests you. I don't want to bad mouth KOffice, because I have nothing bad to say, but I have watched this over the last couple of years and the cycles are pretty easy to predict now.
If you think that KOffice will never catch up, then why so much work is going behind KOffice? If KOffice can't catch up Hancom office, then how can it catch up MSOffice ever? Why anyone will ever switch to KOffice? If KOffice can't get ground then what is the point on developing it further or goal of KOfice is to just provide a alternate inferior office suites? It's better to be involved in a propritary project like hancomoffice than doing hardwork in vain.
I don't think it is because any one wants a free office suite. There are already free office suites more mature than KOffice.
I didn't really express myself well on this point. I've been swamped since the show and I've done my best to keep up on these talkbacks, but I haven't always had the time to articulate things properly.
KOffice is an impressive piece of work for what it is. The sad truth is that there are just hardly any programmers working on it at the moment, and I don't know if that is likely to change any time soon. When you are working on a project in your spare time because you find it fun or interesting, you will probably stop working on it when it ceases to be fun or interesting so work proceeds in fits and starts. Given this kind of development model it would be very hard for KOffice to reach the same level of functionality as any commercial suite. The upside however is that it isn't likely to end up with a lot of bloat and meaningless features to try and justify upgrades.
I say these things with all respect and support for KDE and KOffice, and it is very likely that the feature set in KOffice currently will satisfy a good number of users, but not likely to satisfy power users at this stage (you wouldn't believe the things I've seen people do with a spreadsheet).
Hopefully that is a better explanation
the past is only an indicator of the future when conditions are similar. in its early days koffice had the extreme disadvantage of working against a fluctuating, unstable set of libraries whose user base was small. side effects of this included fewer developers available, more work required just to keep up with the libraries, core KDE developers were concentrating on the core (surprise) ... and i'm sure there are others. look what happens when even just one of the core developers jumps on an application in the case of David Faure and KWord.
don't bank on KOffice not making it out of the shoots as a serious suite; instead i would plan on competing with them on the KDE desktop, much as Hancom will with Open/Star Office. though that one is even trickier IMO: more mature, corporate backing, multiplatform, existing user base.
hrm, here's a question for you Shawn: assuming Open/Star Office manages to trim their binary size down to not be a huge whale of a suite, what would you site as the advantages of Hancom vs Star Office?
Easy to predict, hum? Well, people like you predicted that since Linux was developed in people's spare time it wouldn't go far and now look at it... Same goes for the KDE project.
It's funny how after you "contributed" to KOffice you now say "let's be realistic". What makes you think that Hancom can beat it? That it can beat Microsoft?
If you think it's the simple fact it's not free software than you should forget about it. Much larger and more complex software (go write a kernel, a C library and a C compiler) than an office suite has been developed and so will KOffice.
In the meantime the community can use OpenOffice.
I agree, but I'll use Koffice instead, I tried it an I love it. I don't think enough people used it until now to allow for the very fast bug fixing/development that goes on in KDE.
I can't believe it was only 9Mb...
Many thanks,
Will you permit improvements into Kivio in KDE CVS that makes the GPL version somehow better than the commercial version by adding some new stencils or functions?
We can't really control that can we. Other people have already added some stencils, well one anyway.
>I really am impressed with the work that has gone into KOffice over the years, but you have to be realistic about it. There is only a couple of people working on it part time. KOffice is so far behind HancomOffice it will never catch up.<
Some contradictions here Shawn. How can you be "impressed with the work gone into KOffice over the years" and then, at the same time say "it will never catch up". You know that KOffice have make tremendous progress in last 8 moths (se here: 8 months) since David Faure came to KOffice project and helped other KOffice developers. Kword, for example, was totally unusable when it was released with KDE 2.0.
At the other hand, HancomOffice has been around for about 10 years (see here: 10 years) and how come that it has never been accepted as an reliable office-suite. Something is rotten here.
If it is true that HancomWord runs through Wine I can just imagine why it has never been widely accepted by Linux users. I doubt it also that it will ever be accepted on windows platform because there are some free office-suites which are totally free there: StarOffice and 602-Office suite. BTW, 602-Office suite is very small and very good.
It sounds a little bit arrogant when you say that KOffice will never catch up. We'll see.
>KDE is interested in the desktop more than the office space, they want to see applications that people will use on the desktop.<
KDE is desktop environment which is IMHO more than pure desktop. Otherwise KDE would ship without Konqueror, Kmail, Knode & other network apps, Games, Multimedia (Music Graphics & Video), KOffice, Utilities etc. etc. What are they if not applications?
So, I don't see that KDE is only "interested in desktop".
What you don't know or realize is that HancomWord is enormously popular in Asia and has been for a long time, but it was always a Windows application. Hancom made the decision a year or two ago to go to Linux and the word processor was the last piece to move away from Windows. Hancom has never made any serious attempt to penetrate outside of Asia until now, the Korean, Japanese and Chinese markets are very large. They only made an office suite of it 1 year ago, and it has been selling very well with large contracts signed in all of the above mentioned countries.
I can be impressed with KOffice and respect the work that went in to it and still be honost enough to realize it doesn't have the resources to really go hard core forward. It will continue to slowly evolve and will certainly be adequate for many uses.
KDE is primarily interested in having the desktop complete and then getting applications on there. The goal is to have people using KDE. No one gets KDE so they can use Kmail for example.
> No one gets KDE so they can use Kmail for example.
you are quite wrong on that one. i know many people who do not run the KDE desktop but run the KDE applications. as a great example, a good friend and developer buddy of mine runs blackbox but keeps up with KDE CVS specifically for 3 applications: konsole, kmail and konqueror. he doesn't care for nor use the rest of the software in kdebase.
I can confirm this. A LOT of users here in Estonia are using KMail, Konqueror and sometimes Koffice apps and Konsole. Mostly they are using Windowmaker or Blackbox as windowmanager.
you guys are missing the point that I made, but that's fine.
I thihk Shawn's point was misunderstood...
The point is simple - no one installs KDE just to run for example Konsole, or kate, or kvim.
I'm not making it up - go see people complain why when they want to run Konqueror - it loads the memory with all the services - it is because Konqueror needs every one of them - so it loads them - and people complain about it..
Lets be realistic on a specific part - if you use Konqueror, konsole and kmail, then there is no point of running Window Maker or gnome as your primary Window management - does it?
Yes, you are wrong. Couple of my friends do just that. They download KDE so they can use konqueror and kmail. Actually, for one of them Kmail was THE reason to leave Windows.
They prefer iceWM as window manager and they are not ready to give it up just because they like some KDE programs. They also don't feel the need for other things like kicker.
I don't know what Shawn's point was, but I know what mine is. You have all kinds of people who use software for all kinds of things in all kinds of ways. We might guess what majority of them likes, but we certainly can't say what no one does.
You are right about it - but I was talking about the majority ones..
Back at my previous job 2 years ago - I wish I had a program like Konsole under windows...
see name & subject
I actually DID get KDE just for Kmail - the vanilla MUAs for Gnome were a pain to set up for POP access. The fact that other nifty stuff also comes with KDE was a happy coincidence.
Ahhh, thank you Shawn. Very informative as always.
> Let me say in closing that the interest at LinuxWorld was nothing short of astounding.
> We had virtually every major player want to partner with us, people wanting to put it
> in their companies. [...] There is a tremendous amount of excitment over this.
Congrats! Sounds like you made a very wise business decision! Good luck; I can tell that theKompany is really going places :-)
While I can see all the applications are generally owned by you all, the Email client comes into question. This was a spin off of Magellan code, and while I have to admit there is very little of it that looks or acts the same now, it was still based on this code. Therefore, while you could GPL the code, the original copyright owner is still the originator of Magellan code, so can you now relicense it under a closed source license?
Yes I do understand that the original Magellan code was BSD, however once you moved from BSD to GPL you lost the right to simply say we can just relicense to our hearts content. For all the other stuff I wish you all well, but this one thing has me wondering. It is a dangerous road you are on with the email client, as there was already some infighting between your team in the original author.
Beyond that, I hope you all define the status of Quanta fairly soon, I am actually considering doing some work with it going forward but want to know if it makes sense to work with the current stuff or to just spin it off to play with until I know what will happen. I feel strongly that KDE needs a free HTML editor as part of its bag of tricks.
Good luck, and the screen shots look good, I will definitely be watching for this to go live (oh and I am still waiting on some features for your financial software before I purchase).
As the GPL license holder we can dual license or change the license as much as we want, but we can't take back what is out there. There is very little of the original Magellan code left in Aethera at this stage, it probably would have been easier to start from scratch. In any case we haven't decided to change the license of Aethera/Quicksilver at this point anyway.
Thank you for responding. I was wondering what the whole Hancom thing was when I saw it at Linuxworld. Is there a feature list of the office suite anywhere? I saw the one on the Hancom website, but it just had a few highlights. Also, it may help to have a comparison between Hancom office and the other office suites available for Linux. This would really help people know what the advantages are versus the collective Linux community rolling its eyes about yet another office suite.
Let me add some words to this.
First of all I would like to congratulate Hancom and theKompany with their product line-up. It looks very impressive.
As far as the relation between KDE and Hancom/theKompany goes I guess it is important for people to understand that KDE is basically three things:
1) A desktop runtime environment (kdesktop, kwin, kicker, ksmserver)
2) A development platform (qt/kdelibs)
3) Appplications (konqueror, kmail, kdevelop, koffice, etc...)
I expect to see an increase in the near future of commercial companies like Hancom and theKompany who will support KDE when it comes to point 1) and possibly 2) but who will compete on point 3) because selling commercial applications is their business with which they want to make a living.
If you look e.g. at Linux word processors you will see koffice, star/openoffice, abiword, Hancom Word and WordPerfect. That's the kind of competition that a healthy market needs and that is so much missing on the MSWindows platform.
For KDE I can see three major points that we should work on:
*) Advocate KDE as the desktop solution of the future.
*) Make it attractive for commercial software vendors to use the KDE development framework, not only Qt, but kdelibs as well.
*) Keep commercial companies on the tip of their toes by making free applications that kick ass.
Commercial software companies might not like that last point and some of us might not like to see commercial applications competing with our own brain-childs, but instead of wasting time on the differences in interests, we are better of focussing on the things we have in common and work together in those areas.
Just like we can work together on konqueror with some of us preferring vi and some others emacs, with some of us working for SuSE and some others for Mandrake, we can also work together on kivio with some of us preferring KWord and others Hancom Word.
Everyone has its own reasons for working on KDE, it are the things that we have in common that have made KDE successfull.
(+5, Insightful)
Well said, Waldo...way to go, Shawn!!
8) As I recall you said that there would be a cut down GPL version of Rekall in KOfiice, is this canceled as well?
16)If the filters are as good as you say then you may be going somewhere :-). Should i be right to expect that since their apps have been very popular in asia that international language support (Greek in my case :-) ) will be excelent too?
17) How about a wrapper (in the linux version)0arts/Bonobo, so that your suite could communicate with everything?. Some standards would be nice you know...
I wish you good luck, since you already helped KDE an Linux a lot.
8. We had been trying to think of a way to put Rekall in KOffice, but had never really solved the problems before deciding to make it Qt based, so as a pure Qt application it doesn't make sense in KOffice anymore.
17. Hadn't thought about greek yet, but there shouldn't be any reason why we can't support it. Does it have any odd requirements like BiDi or anything? I would be interested in support it.
Hi Shawn,
After reading your explanations I haven't really understood what you are exactly planning with Rekall...
You said there will be a "stand alone" version.
Will it, to use the terms of your website, remain a "project" or will it become a "product"? In other words: do we have to pay for the final version?
(who thinks your decision is a good one for your company *and* the Linux World)
Hi Juergen,
The plan for Rekall was always to have a commercial product at the end of the day.
OK, then I got something wrong.
I thought your plan was to provide a base version of Rekall for free, while selling commercial plugins for it (I thought I read this somewhere before I started using it).
But of course you are free to change your strategies. I just wanted to be enlightened, for I'm using Rekall beta for my PhD and therefore want to know if I can count on it in the future.
The idea was to have a free basic version that didn't include nested forms or reports, something like that. And then sell the 'pro' version for about $80 USD. That might well still be the case, we just have been focused on finishing the app first.
That's what I meant.
I am very pleased to hear that you still think about it.
I think it's a good way to get a widespread userbase (and helpful feedback).
And believe me, I am the least who wouldn't pay $80 for a good, stable product (after having the chance to try it out) ;-)
Will it be possible to buy HanComPainter only?
It looks nice.
we haven't really discussed it, but I've always thought that making each piece available stand alone would be a good idea.
Good, then my personal needs will probably be satisfied with KOffice, complemented with a basic Rekall and HanComPainter.
One question missed ;)
Will the Hancom file formats be documented and open to use? Will HancomOffice be friendly and have import/export filters for open source application (KWord, KSpread, AbiWord, gnumeric, etc.. )?
actually this topic hasn't come up yet so I don't have an answer for you.
Not "KDE is coming to Main Street", but QT is. And I don't think any KDE fan should like that. Not that QT is bad, of course it's great and all. But it's not a KDE product these guys are planning. Why don't they use all those wonderfull features KDE adds to QT (such as KPrinter etc.)??
I think QT going mainstream is better for KDE in the long run. Why?
Well, As windows developers start coding with QT, when/if apps like Hancom Office become more popular, they'll realize that porting to linux/mac is easy, thus bringing more developers into the fold:
Making QT a popular choice can do nothing but help KDE. Hell, most open source developers are either dedicated to coding for either KDE or GNOME, or something else. Windows programmers learning QT will be able to transition easily to KDE, and that's important, because there are still TONS of Windows guys out there than can benefit by having their code work on ALL platforms. I can't tell you how many windows apps that I use in windows are still "working on linux versions", with QT, it's relatively easy to write (almost)once, run (almost)anywhere.
As great a work as the KDE guys have been doing so far with the core desktop, getting the thousands of Windows programmers out there to develop in QT will only help us where we need it most, end user desktop application development for linux/bsd/whatever. I can't tell you how many programmers that I run into dont even KNOW that such a powerful cross-platform toolkit exists, I have to prove it to them! This is a market where the Trolls need to be pushing! QT for everyone, that's what I say! :)
Good luck theKompany!
Maybe "the Qompany" is a better name :-)
It is hard this times to get money. Venture capital is over now.
I think Ximian and VA Linux are trying to make money from Open Source. I readed carefully the ESR letter about Source Forge Enterprise Edition and I agree with his point of view.
Some people are willing to pay a check in order to have the right to blasfem when things go wrong, even when they arent getting real support (Microsoft fixing bugs? He).
Heh. Isn't Shawn Gordon a bit like Q? He keeps popping up everywhere... :)
I didn't switch to GNU/Linux and KDE merely to see organisations like the Kompany transform it into a propriatory Microsoft Lite environment. For some, including me, the move was more philosophically driven than practically. As such, I have to say that I see the Kompany more as a kind of leech, particularly in the latest announcement, than a userful contributor to everything behind the spirits of the projects they supposedly emerged as supporting.
I wish KOffice the best of luck, because our and our children's intellectual freedom is only assured through a freely developed infrastructure upon which it may be expressed.


text:
New KING Art dev blog post released as The Raven nears launch
Developer diary highlights four major changes in the game's development process as The Raven – Legacy of a Master Thief is finely-tuned ahead of release
Vienna, AUSTRIA (June 25th 2013) – Whilst Nordic Games is doing the final shakedown for its new point-and-click adventure, developer KING Art has just shared a new blog in its dev diary detailing the four biggest changes in The Raven – Legacy of a Master Thief.
"The Raven is the most complex adventure we have made to date. We have tried a lot of new things and put a lot of work into the game. The result is approximately 20 hours of a mystery adventure with a convoluted story, in which you play both the investigator and the delinquent," said Jan Theysen, Cofounder & Creative Director of KING Art.
The Raven – Legacy of a Master Thief will be released in three chapters: first chapter – July 23rd 2013, second chapter – August 27th 2013, third chapter – September 24th 2013. The boxed version including all three chapters will be released October 24th 2013.
About Nordic Games GmbH / The Adventure Company
Nordic Games GmbH is a wholly owned publishing subsidiary of Nordic Games Group AB. Founded in 2011, the Vienna/Austria based company Nordic Games GmbH puts great emphasis on its extensive game catalogue. The core portfolio comprises products and brands which have been acquired from JoWooD Entertainment AG, DreamCatcher Interactive Inc. and THQ Inc., and further IPs and trademarks will follow.
The company will pursue the long-term goal of delivering quality products that live up to expectations of gamers worldwide.
About KING Art GmbH
KING Art is an award-winning independent game developer specializing in producing high quality games. They are among the leading experts on story-driven games in Germany and have produced several successful adventure games that received rave reviews by the gaming press. Since 2002 they have also been pioneers in the area of extensive browser games, and have accumulated expert knowledge during the production of more than 30 successfully completed browser game projects.