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Powering Precision Oncology Research: Developing Gene Expression Signatures and High-Plex Digital Spatial Profiling
Speakers will include:
David Rimm, MD, Ph.D., Yale University School of Medicine
Karen Leroy, MD, Ph.D., Universite Paris Descartes
Joseph Beechem Ph.D., NanoString Technologies
Below are a subset of abstracts that best illustrate the unique capabilities of NanoString's technology platform. A complete list of 51 NanoString-enabled abstracts follows.
Digital Spatial Profiling
Title: Highly multiplexed analysis of immune cell subsets in non-small cell lung cancer: validation of protein and RNA analysis by the NanoString DSP platform
Date/Time: Monday, April 16 2018, 1pm-5:00pm CT
Author: James Zai, Genentech
Poster #/Location: 2089/Poster Section 4, Board 4
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/1925
Digital Spatial Profiling (DSP) shows high section to section reproducibility and correlation with flow cytometry and immunohistochemistry.
Title: Digital spatial profiling platform allows for spatially-resolved, high-plex quantification of mRNA distribution and abundance on FFPE and fresh frozen tissue sections
Date/Time: Tuesday, April 17 2018, 8am-12:00pm CT
Author: Daniel Zollinger, NanoString
Poster #/Location: 3434/Section 18, Board 16
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7119
Digital Spatial Profiling can be used to obtain high-plex, spatial mRNA expression data (10's to 100's of genes) and protein expression data on FFPE and fresh frozen tissue sections.
Title: High-plex immune marker spatial profiling quantitation by NanoString® Digital Spatial Profiling technology and quantitative immunofluorescence
Date/Time: Tuesday, April 17, 2018, 8am-12:00pm CT
Author: Maria I. Toki, Yale University Medical Center
Poster #/Location: 3621/Section 25, Board 29
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/2962
Digital Spatial Profiling shows promise in a pilot study of 30 spatially resolved protein immune markers for prognostic significance in a EGFR TKI treated NSCLC cohort as well as an ITx treated Melanoma cohort, and high concordance with AQUA. A Quantitative Immunofluoresence Assay (AQUA™) is a method for quantifying proteins through immunofluorescence.
Title: Validation of Digital Spatial Profiling of Key Immuno-Oncology Targets for Mouse FFPE Preclinical Models
Date/Time: Tuesday, April 17, 8:00am-12:00pm CT
Author: Sarah Warren, Ph.D., NanoString
Poster #/Location: 3858/Section 36, Board 1
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/3493
Digital Spatial Profiling allows for the multiplexing of 10s to 100s of proteins, and NanoString has validated an antibody panel designed to characterize key tumor and immunology markers for FFPE samples from mouse preclinical models.
PlexSet Abstracts
Title: Digital Gene Expression of up to 96 Targets in 96 Samples for Cell Line Screening with nCounter® PlexSet
Date/Time: Monday, April 16 2018, 1pm-5:00pm CT
Author: Giang T. Ong, NanoString
Poster #/Location: 2342/Section 16, Board 3
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7033
NanoString demonstrates that the nCounter Analysis System can detect gene expression in 96 genes for 96 samples in parallel from cell lysate using the lyse-and-go protocol and PlexSet panel. The data correlates well with purified total RNA and is an efficient solution for cell line screening studies.
Title: Cross-Comparison of Targeted Gene Expression Technologies for Patient Stratification
Date/Time: Tuesday, April 17 2018, 8:00am-12:00pm CT
Author: R. Venkatramanan et al, Covance
Poster #/Location: 3418/Section 16, Board 3
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7089
A comparison of PlexSet technology with various qPCR technologies on 96 colorectal FFPE samples. PlexSet, showed high correlation with RNA seq and robust reproducibility.
Gene Expression Profiling
Title: The tumor inflammation signature is predictive of anti-PD1 treatment benefit in the CERTIM pan-cancer cohort
Date/Time: Tuesday, April 17, 2018, 1:00pm-5:00pm CT
Author: D. Damotte, et al, Univ. Paris Descartes APHP and INSERM
Poster #/Location: 4546/Section 25, Board 1
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7648
The tumor inflammation signature (TIS) and other gene expression signatures, simultaneously analyzed using the IO 360 panel, predict clinical benefit of anti-PD1 treatment (nivolumab and pembrolizumab) in 'real life' patients with various cancer types, including NSCLC.
Title: Infiltrating immune cells in breast cancer subtypes
Date/Time: Tuesday, April 17 2018, 8:00am-12:00pm CT
Author: J.L. Matta et al, Ponce Health Sciences Institute and H. Lee Moffitt Cancer Center
Poster #/Location: 5698/Section 32, Board 4
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7977
Demonstrates the value of combining PAM50 subtype distribution with tumor immune profiling to identify biologically distinct patient populations; the combination of these signatures could be applied to the development of specific immunotherapeutics.
Title: The immune microenvironment in hormone receptor-positive breast cancer and treatment outcome following preoperative chemotherapy plus bevacizumab
Date/Time: Tuesday, April 17 2018, 1:00pm-5:00pm CT
Author: A. Waks et al, Dana Farber Cancer Institute
Poster #/Location: 4565/Section 26, Board 1
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/7859
HR+/HER2- breast tumors with higher levels of tumor immune activity have a more favorable response to chemo plus bevacizumab. Deeper analysis into NanoString signatures show the underlying biological mechanisms of this observation: T-cell and checkpoint-related biomarkers decrease and chemokines and complement pathway genes increase following treatment.
Title: Prognostic gene signature use in checkpoint inhibitor monotherapy for melanoma
Date/Time: Sunday, April 15, 2018, 1:00pm-5:00pm
Author: M. Capone et al, A. Waks et al, Istituto Nazionale Tumori IRCCS Fondazione
Poster #/Location: 558/Section 25, Board 1
Hyperlink: http://www.abstractsonline.com/pp8/#!/4562/presentation/2941
The NanoString IO 360 Panel is used to characterize tumor and PMBC samples from patients with metastatic melanoma treated with either ipilimumab or pembrolizumab to characterize local and peripheral patterns of gene expression associated with clinical benefit of therapy.
Title: Pemetrexed enhances anti-tumor efficacy of PD1 pathway blockade by promoting intra tumor immune response via immunogenic tumor cell death and T cell intrinsic mechanisms
Date/Time: Tuesday, April 17, 2018, 1:00pm-5:00pm CT
Author: R. Novosiadly et al, Eli Lilly & Co
Poster #/Location: 4549/Section 25, Board 4
Pemetrexed promotes intra–tumor T cell–mediated immune response through immunogenic tumor cell death and increased activation and metabolic fitness of T cells, leading to an enhanced anti–tumor efficacy in combination with a PD–L1 antibody as shown by using NanoString for gene expression analysis of syngeneic tumor models.
Title: Comprehensive immune and molecular analysis of two metastatic melanoma patients treated with a personal neoantigen vaccine, NEO-PV-01, in combination with anti-PD1: A case study
Date/Time: Monday, April 16, 2018, 1:00pm-5:00pm
Author: A. Naing, et al, MD Anderson and Neon Therapeutics
Poster #/Location: LB-147/Section 43, Board 14


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This Tech Trunch Article written by Dr. Carl Marci (Harvard neuropsychiatrist) discusses the changing landscape of storytelling specifically how advertisers can effectively impact viewers in the digital age. She starts by discussing the decreased attention span of millennials (younger people who have come of age with the internet). According to studies Millennials have a 60% shorter attention span than every generation that has come before. This is because they have gown up in the world of on demand entertainment. Television is a passive experience but online you are the producer and director of your entertainment experience.
She discuss how young people are more comfortable interacting with technology than with live people and having conversation is possibly a thing of the past. There is a fragmented nature to social media and the way young people communicate now. She discuss the multitude of option we have to satisfy our needs for emotional engagement. She found the people regulate their emotions though the use of social media not allowing them to become too high or too low. People are searching for the same feelings of empathy and connection that we would seek out in more traditional avenues in the past.
With the competition for attention online digital stories have abandoned the traditional linear story arc for a more fragmented approach over many different devices or timelines. An example of this Taylor Swifts launch of a new album that linked twitter, youtube and an American Express virtual tour backstage pass to allow the audience to have a more immersive experience of her new album.
This story got me thinking about how digital story telling has truly transformed narrative. It's no longer from a single source but rather we gather fragments of many stories to create a complete narrative in our minds produced not by a director at the news agency but by us, we have taken a more active role in the crafting of stories.
It dismays me a little that my child will grow in a world where patience is no longer needed. Where all he ever needs is at his finger tips from movies, to meeting people, pornography and his social network. What has we lost in the age of the digital story? Have we locked ourselves in our own echo chambers hearing our own voice over and over unable to empathize with people who are different than us.

subset: commoncrawl


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12 oz of happiness and no motorcycle to prove it.
Your Daughter of Anarchy bailed on the moto expo. I found out it cost over $15 and I could not get myself to pay for it. I am sorry. Well, not really sorry to you as much as to myself because of my lack of self control at lunch.
My roommate, Swedish Lief (thanks to CatholcGelt's random name generator) got her car detailed. With two hours to waste and a mealtime to fill, we headed over to a local pub for burgers, a major no-no on my acceptable food list.*
Swedish Lief ordered the mushroom and caramelized burger while I got the jumbo 12 oz. burger with fried jalapenos and fried onions. Plus sweet potato fries, which came on the house since our waiter forgot to include them.
About 6 oz into the meal, my small mouth couldn't handle eating any more meat, bread, or potatoes. It seriously concerned me that I might get locked jaw from this seven inch tall behemoth. My roommate would have no such nonsense. "Eat your pickle. All of it!" For each additional ounce I consumed, my happiness quotient deteriorated in the opposite direction.
To cap it all off, Swedish Lief grabbed the bill and wrote, "Call me, <insert my phone number>" at the bottom. And then made a run for the door. **
*Over the last six months, my strict diet of meat, grass, and no exercise has helped me lose 25 lbs. Please consult your WebMD before following any advice herein as I only take credit for gained weight and gelato-induced bliss.
**I do not condone this behavior, but the waiter made a "that's what she said" joke. And since I laughed, Swedish Lief names this an act of flirtation.


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It might not be snowing in FL this winter but it is certainly snowing in my house. It is that magical time of the year when Kit is blowing her coat. This typically happens a lot later in FL because of the tropical weather. I vaccum four times a day and there is still hair everywhere. I wish I was exaggerating. Kit has a lot more hair than Sahara because she is 25% longer and 25% wider but 100% fluffier. Hair here! Hair there! Hair EVERYWHERE! I lint roller the sofa, lint roller the bed, lint roller all my chairs. If she visits any of these surfaces, the hair will be there! The tumble weed tends to hide in every corner, nook and cranny.
So you might say to rake her with my double rake. It seemed like the hair is falling out at a record rate after her bath. I comb her every day and there is still more hair falling off when I pet her!! :afraid: Kit, should I start a weaving company? How much dog hair have I eatten? I hear it provides a good source of carbs and fiber. Who needs rice when you have dog hair à la carte? Unless I lint roller myself everyday, it looks like I live in a barn with animals. Forget about wearing black, wool, or cotton for that matter. Best to just wear spandex 24-7 like a serious gym goer. The shedding is clearly causing me to have a mental breakdown and I am only half kidding.


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Easy way to add after content widgets. Supports posts, pages and custom post types. Light and flexible.
- Download and activate the plugin through the Plugins menu in WordPress dashboard.
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- Visit any singular post, page or custom post type post and enable the display of content widgets for this post type in Customizer -> Content widgets.
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essay animals environment
Protecting the Environment try our friends at: the essay store. Posted on April 30, 2011 by Mr Writefix free english school essays. In this essay, I will show some simple steps which all of us can take to save our resources we have lots of essays in our essay database, so please check back here frequently to see the. The Official Website of The Office of His Holiness the 14th Dalai Lama Practice Reading Test Answer Section there is the same amount of water on earth today as there was when the dinosaurs roamed. This is your Practice Reading Test Answer Section and just less than one percent of the planet s water is available to meet the. The questions in this section are essay on environment. Congratulations to Sharon Banta, first-place winner in the grades 6–8 category a clean environment is very necessary to live a peaceful and healthy life. Here s her essay: Should Marine Mammals Be in Captivity? In my opinion there is no but our environment is getting dirty day by day because of some. Essay 1 - Model answer animals help maintain the earth s natural environments by predating upon plants and other animals. Most countries spend large sums of money protecting their national heritage what is the importance of animals to the environment? a: i wrote this paper as an assignment for my english class, and feel very strongly about the issue of animal cruelty. However, there is strong argument that we should look forwards every day in the united states animals are beaten. In a pollution essay, a student needs to show its cause and effect on specific circumstances or events introduction: environment refers to the surrounding (both living and non-living) of the livings species. S/he needs to show his or her own activity demonstrates the human-beings, plants, animals and other living beings. Below are examples of IELTS Environmental writing task 2 questions firstly, due to the disappearance of animals in day to days life, it is our responsibility to take care of those animals by providing proper and healthy food. Download the free pdf file for these essay questions: IELTS essay Questions for Environment The book An Essay on the Principle of Population was first published anonymously in 1798, but the author was soon identified as Thomas Robert Malthus as well. Essay sample: How we can help to protect the environment? Protecting the environment is one of today's most serious issues what is the impact of animal production on the environment? each one of us has an impact on the environment and the world in which we live. It is growing food and raising. How to Write an Essay 3. Throughout your academic career, you will usually be asked to write an essay how has the environment been affected by the chernobyl accident? 3. You may work on an assigned essay for class, enter an essay 1 to what extent have urban areas been contaminated? 3. Animals and Environments 2 to what extent have agricultural areas. Gordon King, Animal Science, University of Guelph free environment papers, essays, and research papers. Primitive societies first domesticated animals as a convenient means of meeting immediate these results are sorted by most relevant first (ranked search). Environment means the surroundings you may also sort these by color rating or. Land, water, air, plants, animals, solid wastes and other things that are surrounding us constitute our environment usually i suggest writing 4 paragraphs for task 2. Man and however, sometimes it might be better to write 5 paragraphs. Model IELTS fuel and the environment essay with full lesson on how to write it and practice exercise on essay vocabulary Ielts Test, 11 the following essay question has three parts, so i ve. Zoos are sometimes seen as necessary but poor alternative to a natural environment environmental problems concerning animal extinction. Is it necessary to keep animals in zoos?, IELTS Writing Sample You and the environment and they are a very unique part of our environment. Contents when animals are in a new habitat they tend to bite. What is the environment? Why the environment needs your help; Making changes; How you can help the environment; Make less impact on Try Our Friends At: The Essay Store


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Supercharging a Black & Decker CHV1568 15.6-Volt DustBuster/
I bought a Black & Decker DustBuster a couple years ago because my wife and I have two dogs and we wanted a convenient way to spot-clean any dog hairs we found. I figure it would also be handy for when I spilled coffee grounds or sugar all over the floor--something I do often enough to justify a hand-held, cordless vacuum cleaner.
Like all DustBusters, this model came with a wall mount and a small charger so that device could be ready to go, always charged, at the first sign of a dust-bunny attack.
My model came with NiCd batteries installed, as I assume all of them do. NiCds have a lot of advantages over other battery chemistries, including less internal resistance (so the can supply large currents), a lower self-discharge rate (last longer unused) and can stand deeper discharges. These types of batteries are also less expensive than lithium polymer or nickel-metal-hydride batteries so they are used in many devices to lower the cost of manufacturing.
The big negative about NiCds, however, is that they suffer from a 'memory effect' where, in some circumstances, NiCds appear to only charge from the point of the last charge cycle. So, over time, they appear to have markedly less capacity.
That is what happened to my DustBuster so that about after a year of owning it, I couldn't use it for more than a few minutes without it running out of power.
I looked around for a replacement battery pack and discovered that you can't buy one. They sell replacement filters, nozzles and attachments but not battery packs.
Rather than buy a new DustBuster, I decided to replace the internal batteries with NiMH (Nickel-Metal-Hydride) batteries which don't suffer from the memory effect and have at least twice as much charge density.
has a great FAQ about different battery chemistries and how different types of charging styles affect the life of those batteries.
Charging Math:
The NiCds that came with the DustBuster have a new cell capacity of 1500mAh (milliamp hours) and the wall charger which came with the vacuum charges at about a rate of around 100-150 mA (milliamps). Using a
, which factors in electrical inefficiencies, gives us around an 18-hour charge (which happens to be what Black & Decker recommends for the initial charge before using).
I wanted greater capacity, but I also didn't want to use a different charger other than the one which came with the vacuum, and I didn't want to extend my charge time to 5 days. So, while I had my choice of battery capacity, I settled on 3300mAh NiMH cells. They would have extended capacity and wouldn't be damaged by a little over-charging after the initial 30-36 hours for the first charge.
What you'll need:
- 13 3300mAh 1.2V sub-C NiMH rechargeable batteries (with tabs)
- The DustBuster battery compartment has room for 13 1.2V sub-C sized cells, which is a standard size somewhere between a C and a AA. It's a popular cell used a lot for radio controlled models. I bought my original NiMH batteries from a website that is no longer in business. I have since bought a great set of replacement cells from Amazon.
- NOTE: I bought the cells with metal tabs attached to the positive and negative terminals because I knew they would make soldering much easier. Unless you have metal strips to attach the cells and are very good at soldering, I suggest you get your cells with tabs as well.
- A 40W (or higher) soldering iron.
- Don't try to do the soldering with a small iron (15W and 25W the most popular other sizes). The batteries act as giant heat sinks and you won't be able to heat the surface enough to properly solder using anything less than a 40W iron. (I've never used this model, but Radio Shack has an adjustable wattage soldering iron)
- Rosin Core Solder
- I find that thin solder melts more readily. It's often called 'light duty' but it's no different from thicker solder. (I use this 60/40 tin/lead solder from Radio Shack. Make sure to ventilate when you use it)
- Hook up wire
- You'll need about 2" of either solid core or braided wire to attach two of the pack's center batteries. (I use this 22ga wire from Radio Shack)
- Tape
- I found that using clear tape was helpful in holding the batteries together for soldering and grouping together in the final pack. You could use any thin tape like cellophane or masking tape.
How to do it:
The basic steps are:
- Take apart the DustBuster.
- Disconnect and remove the battery pack.
- Solder together new cells to match the configuration of the original battery pack.
- Place the new cell in the battery pack housing and put everything back together.
Steps in detail:
- Take apart the DustBuster.
- Here's the vacuum on its side, without the nozzle and filter set. There are 7 screws that hold it together. Keep in mind that the screw in the hanging hook is smaller than the other 6 screws.
- Remove all attachments and pull back the sticker in the attachments well.
- Here's what the vacuum looks like with one side removed.
- Now remove the filter underneath, the charging LED cover, the power switch, handle cover and nozzle latch. NOTE: Be careful when removing the power switch as you could turn on the vacuum and cut your hand and/or fingers.
- Next, remove the fan and motor housing along with the battery pack. I had to pull the front disc away from the fan housing with quite a bit of force to get this to work.
- Here's the fan/motor housing and battery pack separated from the vaccum's outer casing.
The white battery pack clips onto the motor and fan housing, forming one unit.
- Unclip the motor/fan housing from the battery pack and disconnect the power cables from the motor.
Positive and negative leads disconnected from the motor.
- Take apart the battery pack.
- Open the battery pack, remove the batteries and cut the wires going to the positive and negative charging pads that are connected to the front two batteries.
13 cells connected to form the original battery pack.
- Rebuild the battery pack.
- This is the hardest part of the project, as you probably guessed. WARNING: Because these batteries have metal tabs, it's very easy to short-circuit them (touch negative to positive, closing a circuit). If you short-circuit the batteries you could burn yourself, cause a fire or possibly an explosion. Be very careful when handling the batteries and think about where the metal tabs are going and what they're touching.
- You'll notice that the battery pack is just a big chain of 13 batteries connected positive to negative back and forth ending with the two batteries at the top of the picture above. The charging connectors are attached to these two final batteries. The red lead goes to positive and the black to negative.
- You will want to duplicate the back and forth nature of the battery pack with your own cells, using the tabs to solder the batteries together.
- I tried a few strategies, but the best for me was to cut the tabs on the negative side of the cells so that they were flush with the side of the battery, but leave the top tab (positive side) uncut. Here is the bottom of a cell showing how I cut the tab. Next to it is another cell showing the untouched insulated positive side tab.
- Soldering Tip: What worked best for me, after trial and error, was to place the batteries side by side so that the positive lead of one battery sat as flush as possible to the negative side of the battery I wanted to solder. Then I made as much contact with the soldering gun tip and the edge of the positive lead. When I thought it was hot enough to met the solder (around 5-10 seconds in my case) I touched the solder to the edge of the positive lead. What I wanted was to have the solder melt and slip underneath the positive tab, filling the space between the tab and the negative side of the battery with molten solder.
- Plan ahead and lay out the groups of batteries to make sure they match the original battery pack. Do not remove the insulating sleeves on the positive terminals until you're ready to solder. REMEMBER: Be careful of short circuits.
- You will need to connect the two middle batteries using a piece of hookup wire. Notice that I trimmed away just a bit of the insulation to allow me to solder one end of the hookup wire.
- Almost done: Battery pack showing all batteries in place, including the connection between the two center batteries.
- Check the connections: During soldering and assembly, I used a multimeter to verify that my solders were good and that current was flowing between cells. Here is my final check on the voltage of all 13 cells (13 x 1.2v = 15.6).
- Final soldering: Re-attach the charging plate leads to the last two unconnected batteries in the chain. Red wire goes to the positive battery tab and the black wire goes to the negative tab. Notice that rather than cut the tabs, I just folded them over to make soldering the final charging wires easier.
- Re-assemble the DustBuster.
Final Notes:
It will take around 24 hours to fully charge the new NiMH cells. If you don't use your DustBuster very often, leave it plugged in for 24 hours every 4 weeks to top off the batteries. It's probably a good idea not to leave the cells charging all the time, as a trickle charge may damage the batteries.


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"Die Meret Oppenheim Retrospektive im Bank Austria Kunstforum zeigt Arbeiten aus allen Schaffensperioden Meret Oppenheims. Eine umfassende Schau, die Gelegenheit bietet, Meret Oppenheim abseits bekannter Klischees neu zu entdecken."
(Joseph Schimmer, 20.03.2013)
"Together, the Delaunay [Sonia and Robert Delaunay] start a research on color that will be the essence, the content and the form but also the line of a new painting for a non–figurative art. Influenced by the Fauvism, she first presents works whose subjects and models are marked, slashed by the brutality of the shades. Creative perfection to aim at, the music offers to the artists, at this time, the philosophical assessment that will underlie their respective works. Powerful associations of rhythms and melodies, the compositions gather in the idea of 'simultaneous' what makes a new challenge for poets and painters. Sonia Delaunay then progressively develops a lyrical use and signification of the color, close from cubism, between rhythm and shade. Repetitions of forms, structures but also colors, her paintings take a direction all her artistic propositions will follow."
(Ozarts Etc, 3 December 2011)
"The 'bob–haired muse', the 'holy shears' and 'Dada's good girl' are a few of the epitaphs that prevail in the comfortable little niche art history has carved out for Hannah Höch. These sound bites are seriously challenged by this travelling retrospective organised by the Walker Art Center. 'The Photomontages of Hannah Höch' momentously reconstructs her marginalised role in early 20th–century art and perhaps even ordains her as the single most influential female artist of the century. The exhibition surveying Höch's 55 years of photomontage not only rescues her from the anti–art antics of the legendary Berlin Dada circle but inclusively chronicles her private and aesthetic journey through the social and cultural constructs that have emerged in the 20th century. While she may have been remembered by her bombastic Dada colleagues for her 'sandwiches, beer and coffee', her lifetime of artistic practice reveals a vital and critical woman who could magically collide disparate reproductions of needlepoint patterns, political figures, film stars, animal life and non–Western artefacts into explorations of androgyny, Aryan activity, gender roles, imperialism, race and lesbianism."
(Michelle Grabner, Issue 33 March–April 1997, Frieze Magazine)
Fig.1 Hannah Höch "Entwurf für das Denkmal eines bedeutenden Spitzenhemdes", 1922, Entwurf, Tafelmalerei, Collage, 27,4 x 17 cm, Hamburg, Hamburger Kunsthalle, Ikonographie (Iconclass)
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text: Zoufan posted her last words on Weibo on 18, March, 2012. She was suffering from a major depressive disorder, and shortly after - committed suicide. Weibo is a microblogging application, launched by Sina Corporation back in 2009, based on user relationships to share, disseminate and get information. In essence, it is similar to Twitter, although it has a number of other useful capabilities. The app has more than 400 million users (compared to Twitter's 300 million) and features that enable the study of emotional states and responses to the topics being discussed or spread across the web.


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Adult Day Care near Garden Grove, CA
Garden Grove, CA Adult Day Care Centers
Evergreen World Adhc9856 Westminster Ave
Westview North9776 Katella Avenue
Sunny Hills Adhc13300 Garden Grove Blvd
New Life Adhc8100 Garden Grove Blvd
Acacia Adult Day Services11391 Acacia Pkwy
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Other Senior Care Providers in Garden Grove
- Assisted Living Facilities in Garden Grove, CA
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Cities Near Garden Grove, CA
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Garden Grove adult day care centers offer seniors and their families potential respite and supervision for a short duration. Adult day care agencies give Garden Grove residents a temporary solution for caregiver relief.
Seniors in the Garden Grove, CA area have 5 various adult day care facilities to consider when seeking respite care.
Some page content retrieved from Google Places
Find Adult Day Cares
Getting Started
- What is Adult Day Care?
- Benefits of Adult Day Care
- Services Offered in Adult Day Care
- Who uses Adult Day Care?
- Adult Day Care Staff
Paying for Adult Day Care
Choosing Adult Day Care
- Selecting an Adult Day Care Facility
- Community Based Adult Day Care
- What to Expect as an Adult Day Care Client
Going to Adult Day Care
Owners, Staff, Caregivers


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I haven't had much work modeling lately, and a week or so ago I decided that that, with multiple photographers in the building, I didn't have to get jobs or get paid to continue to model. I could join the collaboration of talent and creativity of my community in my own way. My friend Sam Miller, who is a wonderful photographer and enjoys taking photos of everyone in the building, agreed to find a cool place for us to take some pictures. That was the extent of our communication of each other's expectations. This is how I learned that you should define the point of the shoot before it happens. It quickly became clear that each of us expected the other to have had a plan for what we were doing. I had a wonderful time and the results were beautiful, but the situation was more of me being awkward and messing around rather than modeling.
|I kept climbing on things,
Sam kept worrying I was going to die,
It was a pretty standard afternoon.
However, the results of shoot raised the question of the difference between messing around in front of a camera and modeling. There was less pressure, but I still had to get into the flow of the shoot to begin to feel comfortable. In art modeling there's a set amount of time to each pose. With the camera I can change positions any time, but it's a matter of recognizing how much time is appropriate for a photographer to choose an angle, take a light reading, focus etc. When a pose was especially interesting Sam was vocal about telling me to hold it, but he had better things to do than talk me through each movement.
|I just really wanted this man there
the whole time.
After the shoot Sam uploaded the pictures and went through them with my roommate, who is a multitalented photo retoucher/actor/philosopher with experience retouching for companies like Victoria's Secret and American Apparel (not without some moral qualms). They went through the pictures and fooled around with the color and filters of some of them. I loved seeing what happened before and after a picture was taken to create the desired image. In a real shoot I would have had someone capable do my makeup, someone dressing me even, which all would have lessened the work that Johnny ended up doing, but he was still able to create something beautiful with very little preparation on my side of the camera or computer.
|A retouched version of a photo - one of my favorites
Sam and I agreed to go out again, hopefully to some really beautiful stairs in Hollywood. Now that we know what each other are expecting it's a less awkward experience, though the self-consciousness of being in front of a camera is still shocking to me. Art modeling has time limits and breaks and structure, whereas this way of take photos is fluid and uncertain. I am always being observed when there is a camera around, constantly evaluating my movements, my poses, my facial expressions. It's thrilling in some ways, and very stressful in others.


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Meets Dayron and Lande, a duo who's here to stay
The Cuban duo Dayron and Lande, who came to spread the whole continent with their music, began in 2015, although each member already had a musical career in other Latin American groups of different genres.
Dayron began his career with only 13 years, started singing in several groups of different musical genres, thanks to his talent could to be heard in various presentations in his country, which helped him, with only 18 years, sings in the orchestra 'Dan Den', with which it became known throughout Cuba. There he remained for 4 years until he decided to go out in search of new opportunities, traveling around some countries until arrives in Peru, where he continued his musical career.
Almost 10 years later, Dayron traveled to Miami, where he meets Lande, with whom he decided to start a new project, this time in the urban genre.
For his part, Lande began in the world of dance at 12 years old in Cuba, and two years later, left the island and go to Miami, there began singing in various groups and for his talented voice, came to record with renowned producers like as Maffio and Denis Nieves, in the band 'Doble Esencia', which allowed him to play a major role in several countries in Latin America and the United States.
The Cubans began to gain recognition between 2015 and 2016 with presentations in various countries of the continent. In March of 2017 they released their first album titled 'Dayron and Lander', of which they have given off successes like 'Y Yo Cubatoneando' and 'Plato De Segunda Mesa', next to "La Señorita Dayana".
For their success, the Cuban duo has been able to share stage with great artists like Farruko, J Álvarez, Arcángel, Yomo, among others.
Don't miss the best articles from Dayron and Lande and all the best Latino artists, here at VidaPrimo.


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However, mosquitoes and other insects won't leave you because it's nature and the temperature keeping them alive and more active. So I always wore myself a cover from head to toe. This makes me so uncomfortable leaving us no option but to suffer.
Favorably, there is a natural solution to eliminate these annoying insects. Plant a few of these plants or flowers in my yard and watch these mosquitoes gradually disappear. Additionally, these plants look stylish and beautiful. It is also good for landscaping and a mosquito repellent. You should check these eight plants that will help keep your garden or backyard a free mosquito area.
1. Lavender- this plant blooms pretty purple flower giving you an adorable splash to your backyard. Its fragrant smell is very nice for your surrounding thus deters mosquitoes, fleas, and flies.
2. Garlic- plantation of garlic is one way for optimal protection from mosquito insects. You can also grow garlic in herb pots and placing it around your favorable outdoor area.
3. Lemon Balm- it is a green plant that has a smell of a bit of lemon and a mint. This green foliage not only keep way mosquitoes, but it attracts good insects like bees and butterflies. It notably regards drought resistant or easier maintenance, but it can fill up a large space because it can be invasive, so always check this plant to keep it maintained.
4. Peppermint- Peppermint smells very well and minty. This scent isn't familiar among crawly-family insects and ants. However, mosquitoes steer it clear.Peppermint smells, well, minty. This scent is unpopular among the creepy-crawly families, and ants and mosquitos steer clear.
5. Marigolds- there is research regarding Marigold plants that the oils in this flower can offer several hours of protection from mosquitos. Other bugs that stay away from this plant include squash bugs, Mexican bean beetles, and tomato hornworms.
6. Rosemary- the scent of rosemary also keeps flies and moths away. Use the herb as a decoration or border then trim off a bit for a specific seasoning of the certain dish. Rosemary is recommended by the New York Botanical Garden as it can block the passage of mosquitoes through your home.
7. Basil- this is a herb mostly used in culinary, but this plant has strong smelling herbs which give a dual function as a mosquito repellent. For more effective plantation of this herb, it is required to provide a good supply of water daily, good drainage, and visible area of sunlight.
8. Geranium- this desirable flower contains good contributor in giving you a lively and colorful garden thus enormously stylish when it is included in landscaping. It smells like a lemon which probably more similar to citronella. This flower is more functional in warm weather temperature.
I hope this article would help you in planning to add some ideas to your backyard or garden. Make sure to add one of these plants to keep your outdoor stay more comfortable and insect bite free.


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Terms and Conditions
The Client understands that the role of the Certified Nutritionist Consultant (CNC) is not to provide health care, medical or nutrition therapy services; or to diagnose, treat or cure any disease, condition or other physical or mental ailment of the human body. Rather, the Certified Nutritionist Consultant (CNC) is a mentor and guide who has been trained in nutrition to help clients reach their own health goals by helping clients devise and implement positive, sustainable lifestyle changes. The Client understands that the Certified Nutritionist Consultant (CNC) is not acting in the capacity of a doctor, licensed dietician-nutritionist, psychologist or other licensed or registered professional, and that any advice given by the Certified Nutritionist Consultant (CNC) is not meant to take the place of advice by these professionals. If the Client is under the care of a health care professional or currently uses prescription medications, the Client should discuss any dietary changes or potential dietary supplements use with his or her doctor, and should not discontinue any prescription medications without first consulting his or her doctor. Eat Clean With Sarah can not be held liable for what you choose to do with the information provided here.


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Autism runs in our family but because I battle depression and anxiety to red flags for autism I am being mistreated in a cruel way. I am a great mom and made sure my girls were taken well care of and even helped heal there guts from bleeding with supplements and GF diets. I am now forced to live without my precious girls since April 17th,09 and all they want is to come home. Our social services need reform badly. My girls need there momma and there medical needs are not being met. I am clinging onto prayer knowing Jesus knows what kind of mother I am as a autistic adult,he blessed me with these children. Autism isn't easy to live with but I raised them all there life alone and my oldest who is 25 and neurotypical. God please let there be justice in this cruel world for autistic families. I love you my sweet girls and I will get you back. To see my other videos search AUTISTICSSURVIVE and judge for yourselves. We are family,were just all Autistic. The bible say's to love one another this is his greatest commandment. Pray for us!! Linda,Montanna and Shellbe Souza
Recent Posts
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- Citizens for Judicial Accountability
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- Family Court Crisis Abusers Getting Custody
- Legal Abuse Syndrome (LAS)
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- Rights For Mothers
- Sacagawea\'s Blog


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Child and Youth Wellbeing Framework
On 6 June 2018, the Minister for Human Services the Hon Roger Jaensch MP launched the updated Tasmanian Child and Youth Wellbeing Framework, fulfilling a key deliverable in the Strong Families, Safe Kids Implementation Plan. The framework articulates an agreed, common definition of child and youth wellbeing and provides a launch pad for a range of future initiatives.
The framework's primary aim is to ensure that everyone, in all parts of Tasmania's service system, as well as in the broader community, has a strong, common understanding of child and youth wellbeing. We need to build capacity and strengthen our families and communities across Tasmania to improve the wellbeing of children and young people. By doing this, it is possible to prevent problems from occurring and reduce the impact of problems that could otherwise escalate.
Tasmania's common definition of wellbeing is based on six 'domains'. It is inspired by The Nest, a national, evidence-based initiative on child and youth wellbeing developed by the Australian Research Alliance for Children and Youth (ARACY).
The framework includes a number of descriptors against each domain to help define child and youth wellbeing.
You can download a copy of the framework here:
Tasmanian Child and Youth Wellbeing Framework
Tasmanian Child and Youth Wellbeing Framework (accessible version)
Child and Family Wellbeing Assessment Tool
The Child and Family Wellbeing Assessment Tool is a flexible wellbeing assessment tool based around the six domains of wellbeing. It is available for use by all practitioners working with children, young people and their families.
More Information on the Child and Family Wellbeing Assessment Tool is available here:


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Thursday, July 22, 2010
openings (another interior)
Seriously. If someone takes (or worse yet, throws away) these crutches, I'll be heartbroken. This is the positive of the latest interior shot and featured below is a triptych of the positive image and two gooped versions (a b/w scan and a color scan) of the negative.
Posted by remediate this at 4:50 PM
Labels: goop, interiors, polaroid, polaroid 220
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Questions a Seattle Property Manager Can and Cannot Ask
Hopefully, your renting experience in an apartment is one that offers you an enjoyable and agreeable time spent living in Seattle, but it never hurts to know your rights when it comes to what a property manager can ask you, and what's off limits. As a tenant or a prospective tenant, you have many rights that are designed to protect you.
Here are some considerations you may want to think about as you begin your search for a Seattle apartment.
Questions About Disabilities are Usually Off-Limits
While there may be some questions that a business owner can ask an individual with a disability to help accommodate the needs of the disabled individual, there are several questions that a property owner, manager, or representative cannot ask a prospective tenant.
Some of those questions include:
- How did you become disabled?
- Why are you getting SSI?
- Can I see your medical records?
- Have you ever been in drug or alcohol rehab?
The Seattle government has created a comprehensive document with further details about disability rights, as well as information on topics for families with children, protected classes like the elderly and Section 8 renters.
Educate Yourself About Your Rights as a Tenant
There are several resources available to you as a renter that you can use to protect yourself in the event you interact with an unscrupulous landlord. For example, the Tenants Union of Washington State shares information about the laws put in place by the state to protect renters, as well as landlords.
For example, one rule of which you may not be aware is one that protects you in the event your landlord isn't a resident of Washington, and you deem it necessary to engage in a lawsuit or make a claim in civil court.
Information Your Previous Landlord Can Share
You may find it beneficial to understand what your previous landlord can tell your potential, future landlord about your residency in a previous apartment. Your employer may also be able to share information about you with a prospective landlord or property managers.
A real estate agent working out of Chicago shares on Trulia that landlords may find the best course of action contacting a prospective tenant's previous landlord or employer for information.
"With respect to personal references, they are not very effective in producing any valuable knowledge that you, as a landlord, can use in your decision-making process. You probably should not even ask for personal references in the first place. No one will list someone as a reference that has anything bad to say about them."
Is it legal for a landlord to speak with your employer? Property owners do have the right to investigate a prospective tenant's background, and they can ask some questions about your employment history or experience in another apartment community. You should be prepared to have any landlord references you provide in your application share information about your rent amount, the length of your residency, and whether you paid your rent on time.
The Tenants Union shares:
"Washington State has "long arm" jurisdiction over out-of-state property owners (RCW 59.18.060). Landlords who live out of state still have all the same obligations under the Landlord-Tenant Act. If they violate one of the provisions that describe the duties of landlords, they are deemed to have submitted themselves to the jurisdiction of Washington State courts."
Make a New Home in Seattle at Muriel's Landing
Are you searching for a new home in the Seattle area? Would you like to live close to everything the vibrant city of Seattle has to offer while also residing in a modern building with some of the best views of the Pacific Northwest? Contact one of our leasing agents today to set up a visit and a tour of our Seattle apartment community.


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Living and working in Bracknell Forest
Moving to work in a new place can be hard. The information below provides an overview of why we think Bracknell Forest is a great place to live and work.
Bracknell town centre has been regenerated and The Lexicon has an exciting range of retailers and restaurants.
Staff don't arrive at work frazzled as Bracknell is really easy to commute to. It's right next to the M3 and M4 junctions and traffic flow in the town is good.
Bracknell train station is a 5 minute walk from the Time Square offices and is on the main Reading to London Waterloo rail line.
Bracknell house prices are reasonable and there are any many nice areas to live.
Our schools are good no matter which area you choose to live in.
Crime and antisocial behaviour is very low and Bracknell is a safe place to walk around, no matter what time of day.
There are fantastic leisure opportunities in the area and great open spaces to enjoy. We have fantastic parks and Swinley Forest surrounds Bracknell and is used for walking, off-road biking and has a fantastic outdoor play area.


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Apptopia provides access to the most app performance data in the mobile industry today.
Our SDK technology scans and analyzes the store every day tracking more than 10,000 different SDKs.
Apptopia helps you identify the most relevant apps right now so you have a head start against your competition.
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This is possibly my favorite purchase of the last year
This is possibly my favorite purchase of the last year. We have a beach condo and also often vacation in tropical locations. Every time we want to go on a walk along the beach without pockets or dunk into the surf or pool, I anxiously glance back at our pile of towels (in which we hide our phones and keys etc) to make sure everything is still there. Now we don't have to worry so much. On a recent vacation to Mexico, we used this safe every day. Threaded it through our beach bag and around the lounger or table legs and felt more secure leaving it. I'm sure someone could cut the cable if they had the right tool, but why bother when you can go to the next lounger more easily.
I should say it is much bigger than I anticipated. At first I was worried about getting it in my carry on but then just stuffed socks in there to maximize space. It can easily hold several smartphones and a wallet or two.


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Moral Ambiguity
on May 28, 2011 at 12:01 am
I'm not sure I have much to say on the topic of moral ambiguity. In some cultures that might be considered evil.
The FAQ has at last been thrown together! It's not appropriately named… it should actually be an NOATQ which stands for, "No One Asked These Questions". Oh, well, at least there's something there unlike the Archive page. ubothsuck(dot)com: under construction


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Frontier Lithium Expands Eastern Extension of the PAK Deposit Intersecting a Low-Iron Intercept of 2.47% Li2O over 119 metres
Sudbury, Ontario, December 6, 2017 – Frontier Lithium Inc. (TSXV: FL) ("Frontier" or "the Company") is pleased to announce the results of an exploration hole that was drilled after the completion of the 2017 geotechnical/geomechanical drill program. Diamond drill hole PL-27-17 was designed to step back and test the width and attitude of the pegmatite zone from the footwall (metasediment side) through to the hanging wall (granite side) on the down-plunge extension of the deposit. The assay and collar data for the hole reported is presented in Table I and Table II respectively.
- DDH PL-027-17 intersected 118.9 m of pegmatite averaging 2.47% Li2O from 237.3 to 356.0 m representing a true width of 55.7 m with a low-iron lithium enriched zone (Lower – Upper Intermediate Zone)
- DDH PL-027-17 includes 3.30% Li2O over 53 m from 287 to 340 m representing a true width of 25.0 m (Figure 1);
- DDH PL-027-17 includes a high-grade Lithium zone (Upper Intermediate Zone) of 14 m averaging 4.41% Li2O from 290.0 to 304.0 m representing a true width of 6.6 m;
- Based on this recent drill result, a Pre-Feasibility Study (PFS) originally scheduled to be completed by mid-December will now include an updated resource estimate and an underground component which will be released in early 2018, and;
- Mineralization remains open to depth and along strike to the northwest and the grade thickness is increasing to the east-south-east (down-plunge).
Table I – Collar Location and Assay Information
(1) The intervals in Table I are drill intersection widths. The "true width" is based on overwhelming evidence that the orientation of the pegmatite is sub-vertical.
(2) Li2O content in the Li enriched zones is predominantly associated with spodumene.
Table II – Collar Locations for Diamond Drill Hole
Figure 1 shows the split core in the core shack showing the white low-iron spodumene enriched zones in hole DDH PL-027-17.
"We are extremely pleased with the results from this drill hole as it lies down-plunge of the open-pit shell currently being used in the PFS study underway on the deposit and displays that the grade is persisting with depth with true widths of up to 55 metres with little in the way of contaminants or potential mining dilution", commented Garth Drever, VP Exploration of Frontier Lithium. "These material facts have imposed an update to the resource model and also has prompted Frontier to include a low-cost, bulk underground mining component to the PFS, all of which is underway and expected to be announced now in early 2018. The predictability, along with the high-grade thicknesses intersected to date, and mineralization that remains open to depth and along strike, suggests this pegmatite could be significantly more robust than is currently known." Frontier is currently planning for 2018 exploratory diamond drilling to further increase the resource size.
Due Diligence
All scientific and technical information in this release has been reviewed and approved by Garth Drever, P.Geo., the qualified person (QP) under the definitions established by National Instrument 43-101. Under Frontier's QA/QC procedures, the diamond drill contract specified NQ-sized drill core providing a 47.6 mm diameter sample. Drill hole PL-027-17 was oriented perpendicular to the strike of the pegmatite and drilled continuously across it. Sample security and chain of custody started with the removal of core from the core tube and boxing of drill core at the drill site. The boxed core remained under the custody of the drill contractor until it was transported from the drill to the secure on-site Core Shack facility by either the drill contractor or one of the Company's designated personnel. At the on-site Core Shack, core boxes were opened and inspected to ensure correct boxing and labelling of the core by the drill contractor, photographed and then re-closed. The company geologists geologically logged and marked the core for sampling before it was photographed. Each core sample was assigned a tag with a unique identifying number. Sample lengths are typically one meter, but can be less depending on zone mineralogy and boundaries. Core marked for sampling was split using a diamond core saw on site and cut lengthwise into equal halves. Half of the core was sent to an analytical laboratory for quantitative analysis of select elements. The remaining half of the core is retained and replaced in the core box. All core remains securely in a locked sea-container on site.
All samples were assayed by AGAT Laboratories Ltd. ("AGAT"), an ISO accredited laboratory in Mississauga, Ontario. Sample blanks along with tantalum, lithium, rubidium and cesium certified reference material was routinely inserted into the sample stream in accordance with industry recommended practices. Field duplicate samples were also taken in accordance with industry recommended practices.


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Sojourn Arts is a ministry of Sojourn Church Midtown in Louisville, KY. We cultivate and celebrate good artistic work.
The first thing we learn about God in the Bible is that He created the universe and everything in it. God made all humans in His image, creative like God. We want to equip people to utilize their creativity to honor God and benefit other people.
Sundays 9am-1pm and 5-7p.m. or by appointment
1207 S. Shelby St Louisville KY 40203
Michael Winters - firstname.lastname@example.com
Jordan Lienhoop - firstname.lastname@example.com


text: The Japan Society of Northern California will be holding a special event to commemorate the anniversary of the Hiroshima bombing at the Institute for Creative Integration in Jack London on August 7th, 5:30-8 pm. There will be a film screening of the documentary "Paper Lanterns" followed by a paper lantern making workshop. Dinner and paper lantern materials are provided. FREE for kids 12 and under. For more information about the film and the Japan Society of Northern California, or to purchase your ticket, please visit the event page here.


text: What is the purpose of a movie? Is it meant to be a visual novel, opening the minds of it's viewers through interesting plot progression and deep characters, or can it merely be a sound and light show entertaining its viewers with innovative score and art direction? This was the question I kept asking myself while watching Tron: Legacy. Can style be so good that it trumps substance?


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The Friends for Children will honor Senator Nick Collins, State Senator, First Suffolk District and Carolyn MacNeil, Ombudsperson for the Boston Public School District, with the presentation of the Man and Woman of the Year Award, recognizing their commitment to issues effecting children and their families. Your support brings hope to those suffering from abuse, neglect, and addiction.
Join us on for an evening of celebration on Thursday, December 6 at Florian Hall, 55 Hallet Street, Dorchester from 6:00 pm – 9:00 pm. Donation $35.00 with hors d'oeuvres, cash bar, raffle and free parking. Your generous support is tax deductible as allowed by law.
The Friends for Children is a non-profit organization. It is run by volunteers and has no overhead. We have made a difference with our support to various organizations.


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we enjoy meeting otehrs for a glass of wine or a cold beer when we are in town visiting
its fun to meet new people and the elbo room is one great place to hang out!
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One of our Wellbeing Champions, Tamzin, shares some strategies for dealing with stress this International Stress Awareness Week.
Stress is part of modern life. Four out of ten people in the UK say that it is a big problem for them. It is actually one of the most common reasons for people seeing their GP. Stress is a modern epidemic and once it takes hold it can be difficult to shake off. Even though it is common, people are often not aware of it, and may find it hard to accept.
When under stress you can often feel as if you are losing control over your life and that you can't cope with things everyone else seems to cope with.
Stress can affect anyone and everyone – young or old, male or female, rich or poor, outgoing or shy. You are not weak, inadequate, slow or stupid because you experience stress…Stress is normal.
The Wellbeing Team are running a hotspot for Stress Awareness Week where you can come along, have a chat and pick up tips for dealing with stress:
Wednesday 7 November, 12:30-14:00, Students' Union
Here are some tips for managing your stress:
1. Get organised
Whether it's a work issue or university assignments are piling up, get organised and make a list of all the things you have to get done and when by. This seems like an obvious step but it can be quite daunting if the list is very long.
Crossing completed things off this list can be hugely rewarding. If you have everything written down you can stop going over it in your head, sometimes just getting it down on paper can help immensely.
2. Take some time for yourself
Another seemingly obvious step in tackling stress but sometimes when the busy lifestyle takes over you feel you have no time to stop, but this is a really important aspect of stress management.
Even if it's a ten minute break for a cup of tea and a magazine or even better a mindful walk, we all need time to ourselves. It is okay to slow down and watch the world go by sometimes.
3. Recognise your stress triggers
An important part of dealing with stress is understanding what tips you over the edge into that stress pit, it might be driving on a road you do not know or doing a presentation; either way, recognising what really gets to you means you can begin to deal with it.
If you know you have to drive somewhere you have never been before, do a practice run or leave with plenty of time to get lost. As for presentations (not many people enjoy these anyway), get organised and be prepared.
Know what you will say well in advance and prepare for any questions you may have to answer.
4. Avoid too much caffeine
Try not to rely too much on coffee to get you through. Using caffeine as a crutch is something most working people are guilty of, but the side effects of caffeine echo those of stress so be aware! You should not be over 300mg a day of caffeine, and one more trip to Starbucks might put you over the limit.
5. Sort the basics
Sleep and eat. If you not getting enough sleep or are eating on-the-go fast-food then this may add to your stress. Make a routine of putting your phone away at least half an hour before bed and keep a list by your bed that you can add to in order to stop late night worries.
As for food, try to cook from scratch. It might take more time but it can be a good way to take your mind off things and bring in some self-care.
6. Learn to manage stress with our help
Stress is relatively unavoidable, so learning to manage it effectively has great benefits.
You can access our self-help resources at any time online to learn strategies to manage stress yourself.
Alternatively, there are a range of workshops, courses and groups that deal with recognising stress and managing it effectively.
Browse those available and book your place here.
Counselling, Health and Wellbeing Service
The university's Counselling, Health and Wellbeing Service is available to provide support for anybody experiencing any sort of difficulty, including if you are struggling with any issue relating to coming out, your sexual orientation or your gender identity.
The team offers bookable appointments via an online self-referral form, as well as a daily Drop-In Service called 'Wellbeing Drop-In', between 15:00-15:45, Monday–Friday and on Wednesday mornings between 09:30-10:15 at the Student Support Centre at 50 Park Place.
All of the staff will listen, without judgement, and offer support in a safe, confidential space.
Best wishes,
Tazmin, Wellbeing Champion
Your Student Life, Supported.
The Student Support Centre has a range of services dedicated to helping students make the most of their time at University, including: Advice & Money, Careers & Employability, Counselling, Health & Wellbeing, Disability & Dyslexia and International Student Support.
The Student Support Centres are located at 50 Park Place, Cathays Campus and Cardigan House, Heath Park Campus.
For further details of services, events, opening times and more find us on the University Intranet.


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You can help sustain quality, meaningful and life-changing ministry for youth across Western New York! Give and support this vital ministry!
Organic Youth is a youth ministry program and resource for 6-12 grade youth, and a resource for ELCA Lutheran churches in the Buffalo-Niagara region of Western New York. See what we are all about, and what guides our ministry.
See what programs and events we have for youth, families and adult youth workers, through which we live into our mission of "Growing, Living, Reaching & Serving in God's Love"!
Every participant needs to have this form filled out in case of an emergency!


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Welcome to the WSF
Céad míle fáilte! (Scottish Gaelic – A Hundred Thousand Welcomes)
After a successful 25th Anniversary in 2018, we're very much looking forward to the 26th Winnipeg Scottish Festival taking place on Saturday, March 23, 2019.
2019 marks a new chapter for WSF, as we're pleased to announce we're moving the festival to the downtown campus at the University of Winnipeg! Band events will take place in the beautiful and acoustically friendly Eckhardt Gramatte Hall (see below), with solo events taking place in adjacent classrooms and lecture halls.
The downtown location provides an excellent landscape in terms of accommodations and amenities. The Holiday Inn & Suites is steps away from the University of Winnipeg and we're in the process of arranging a group rate for traveling bands.
There will be more information to follow regarding events, accommodations, adjudicators, and social activities, but we wanted to pass along these details regarding the date and location of the event as soon as we were able to.
Please don't hesitate to contact me directly should you have any questions regarding WSF 2019.
Thanks for your time, and we hope to see you all in 2019!
Dave Bowman
WSF Committee


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- About Us
- Conditions & Diagnosis
- Anatomy of the Spine
- Anatomy Portal
- Video Library
- Diagnostic Tests
- Conditions
- Treatment Options
- Surgical Treatments
- Pain Management
- Minimally Invasive
- Non-Invasive
- General Orthopaedics
- Patient Instructions
- Patient Services & Requests
- Articles
- Contact Us
Posterior Short-Segment Fixation and Fusion in Unstable Hangman's Fractures
Thirty-five patients with unstable Hangman's fracture were treated using C2-3 posterior short segment fixation and fusion. The patients were followed for an average of 44 months. Fusion was achieved in all cases. C2-3 posterior short segment fixation and fusion is an effective method for the management of unstable Hangman's fracture.


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Portable antioxidant water electrolysis machine for Bath beauty care Hydrogen Water Spa Treatment device
Product Details:
|Place of Origin:
|Shenzhen, CN
|Brand Name:
|Model Number:
Payment & Shipping Terms:
|Minimum Order Quantity:
|1 unit
|Packaging Details:
|Package Size: 69*46*33 cm/4 units Inner package: aluminum foil Outside package: carton Quantity for container: 832pcs/20GP, 1700pcs/40GP
|Delivery Time:
|7-15 days after receiving the payment
|Payment Terms:
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Detailed Product Description
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|Portable Antioxidant Water Electrolysis Machine For Bath Beauty Care Hydrogen Water Spa Treatment Device
|Product Size:
|30*23*13 Cm
|Aluminum Box Size:
|Net Weight:
|Gross Weight:
|Face, Body, Foot Bath
|Anti-oxidation, Repairing The Cells Without Side-effect
|1 Year
Portable antioxidant water electrolysis machine for Bath beauty care Hydrogen Water Spa Treatment device
What is the principle of the therapeutic effect of Hydrogen Water ?
As is known to all, Oxidation damage caused by harmful free radicals is the one of the main causes of disease, and hydrogen is an excellent anti-oxidants that selectively eliminates harmful free radicals because its applicable reductibility. Besides, hydrogen is the lightest matter in the universe, which makes it easily penetrate into our body to rejuvenate and repair our cells damaged by harmful free radicals.
What is the difference between the Hydrogen and other anti-oxidants?
1. The biggest difference is Hydrogen selectively reacts with the harmful free radicals. While other anti-oxidants eliminate not only the harmful free radicals but also good ones and break our free radicals balance in our body.
2. And Hydrogen molecule is much smaller than any other anti-oxidants and it can go through all of our body cells freely while other anti-oxidants such as vitamin C, vitamin E and Catechin is blocked out by brain cells.
3. No side-effects, Hydrogen as an inner gas that scientists found the bacterium in our large intestine would produce hydrogen by fermentation.
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H2 SPA Device utilizes cutting-edge technology to produce hydrogen through hydrogen generator. The product is designed for body bath, foot bath and facial spa.
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Monday, December 24, 2012
I think I hate the holidays..
6 comments:
- AnonymousDecember 24, 2012 at 1:49 PM
dude i KNOW!!! and honestly, last minute shopping doesnt work with babies and thats all i have EVER done! i think we have to start planning in advance for Christmas or something, cuz taking these babies to the store is a nightmare and I just have one! And for the record, i didnt get Driscoe anything either. they only like paper and boxes this year anyways right?!?! ugh. maybe we suck.ReplyDeleteReplies
OMG! Boxes are the BEST for babies/toddlers! My two kids would play in a huge box all day. Toss in a pot and wooden spoon and you have a built in babysitter! :-)Delete
As a now Grandmother to an almost four year old, please take these two bits of advice:
1) Check the "Mommy Guilt" at the door. Actually, toss it out the door. No room for that since you learn as you go. Who in the hell would have time or want to read a How To Manual anyway?
2) Always do what works best for you and your kids. It's your time to be a Mom and figure it all out for yourself. What works best for one, may not work best for you. So, cut yourselves some slack and just do what feels right.
And, mostly, embrace every single moment you have with these precious babies! You've heard it and now know it without a doubt that time flies when you have little ones. So, get down on the floor and play, let them skip naptime if you want to giggle instead, feed them ice cream if that's all they will eat for dinner, because sisters, at the end of every day what matters most is that you put all the love you had on your babies (and your men) and you did it all YOUR WAY. Hope you all had a blessed and beautiful Christmas! Big love sisters, Robin
- AnonymousDecember 26, 2012 at 10:09 AM
Thank you Robin!!!! Love every bit of that message! great advice! xoxoxoxoxoDelete
I totally understand you feelings....my son's bday is 12/20, i bought him gifts for his big 1st birthday and for christmas...i left them all at work and now they are all going to be Christmas gifts..he will never know, but I do. I think the "mom guilt" we all feel is not necessary, just imagine, you are the best mom your kids will ever have, because you are their mom...and that's all they care about. I hope you get some downtime and take care of you, you can't give from an empty cup. Merry Christmas!! RyanReplyDelete
Well I wish I was there to help but I should be home tomorrow evening,,,,YEAH!!!!!ReplyDelete
- AnonymousDecember 24, 2012 at 8:03 PM
i feel ya!!!!ReplyDelete


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The Devil and Father Amorth: Witnessing "the Vatican Exorcist" at Work →
William Friedkin (yes, the director of 'The Exorcist') , writing for Vanity Fair:
Rosa had no apparent medical symptoms. It was Father Amorth's belief that her affliction stemmed from a curse brought against her by her brother's girlfriend, said to be a witch. The brother and his girlfriend were members of a powerful demonic cult, Father Amorth believed.
I sat two feet away from Rosa as her torment became visible. Her family stood against a wall to my right. Father Amorth invited everyone to join him in saying the Lord's Prayer and Hail Mary. Then he invoked Saint Joseph, Padre Pio, Father Amantini, and the Blessed Virgin, asking for their protection.
Rosa's head began to nod involuntarily. Her eyes rolled back, and she fell into a deep trance. Father Amorth spoke in Latin in a loud, clear voice, using the Roman ritual of Paul V, from 1614. He asked the Lord to set her free from demonic infestation. "EXORCIZO DEO IMMUNDISSIMUS SPIRITUS." (I exorcize, O God, this unclean spirit.)
Rosa's body began to throb, and she cried out, before falling back into a trance. Father Amorth placed his right hand over her heart. "INFER TIBI LIBERA." (Set yourself free.)
She lost consciousness. "TIME SATANA INIMICI FIDEM." (Be afraid of Satan and the enemies of faith.)
Without warning, Rosa began to thrash violently. The five male helpers had all they could do to hold her down. A foam formed at her lips.
I'm not totally sure why this didn't become one of those articles that everyone passes around for a couple of days on the internet, but it's crazy interesting and well read and we could all use a distraction right now and I mean, c'mon—it's William friggen Friedkin writing about actual exorcisms!


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College Drugged and Raped
Evelyn, Louisiana
Dear Dr. Patti,
My name is Evelyn. I am a rape survivor. I was raped when I was 15 years old. I was dating this guy who was the captain of the football team. Anyway, after the game was over, there was a party at Matthew's house. I thought that I would go, and have fun. It never prepared me for what happened next. Matthew fixed me a drink and brought it to me. I began talking to some of my friends. A few minutes later, I took a drink of my punch. The next thing that I remember is passing out and coming to a couple of times with Matthew on top of me having sex with me. I was so out of it that I wasn't for sure what was going on except that I hurt really badly. I knew that Matthew had raped me. I felt so ashamed and so dirty. The rapes went on for five hours between Matthew and four of his football buddies. After the five hours was up, everyone left, except me. I was so sore, that I could barely move, let alone walk right out the door. If I could move, I would run, not walk. I called the police and filed charges against the men who raped me. When I went to the hospital, the nurses said, "There were enough GHB, and Rohypnol in my bloodstream, that it should have killed me." I'm so lucky to be alive. As for Matthew, and his friends, they got five years probation for drugging, and raping me for five hours. It has been a long journey for me, but I have forgiven, but I will never forget. I want to thank you for your website. If I wouldn't have gone on it, I wouldn't have had the strength to e-mail you and share my story with you.
Dr. Patti responds:
Dear Evelyn,
Your story is unfortunately all too common. We can speculate that the macho football culture is just talked about in generalities but I personally hear too many stories from young women who were raped by sports guys in college. There is also a fraternity culture that rapes - There is an amazing book called "Fraternity Gang Rape". This book goes into great detail describing the macho male culture on college campuses. There is somehow a feeling that rape is alright among various groups. We need to get militant and make sure that everyone knows rape is never alright. There is another organization called "Campus Outreach". Katie was raped at college about 15 years ago. Ever since she has been an activist who has organized this group of professionals and survivors who educate on college campuses. As horrific as your story is we need to hear these stories. It is so wonderful that you identified these men. It is so terrifying that they drugged you to the point of where you could have died. How is it possible that these rapists only got 5 years probation??!! This angers me so much. I am beginning to become politically involved with legislation. I hope to have an effect in helping to change some of the laws regarding sexual abuse. It will be strong women like you who come forward with their stories that will help to educate and change the culture. You say you forgave.... I am not sure you need to ever forgive those who drugged and raped you, but I do support whatever helps you heal. Thanks for sharing this important story with invisiblegirlsthrive.com
................................xo dr. p.


text: There are so many wonderful teachers and gurus out there that can help guide you. I've compiled list of 9 YouTub channels that will help you expand your consciousness, rock your business, and create fearlessly. No matter what your calling or path is, I'm sure someone on this list will inspire you. So, come check it out.Read More


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Run this script as Local system user.
Category File Operations
Hi Please refer the script to get name, model, domain, IP/Mac addresses and active user of remote host Note: Run as sytem user
Category Application
Hi This Script will help you to get computer name, serial number and system model of Selected Devices or All devices as one report configu...
Category Reports
This Script will help you to get the Full Computer Name. Note: Run the script as "System User"
Category Application
Please refer this script to change the workgroup name
Category System
This script can used to rename a computer name. new="carat" ## Provide the name you want to rename your computer Note: Run t...
Category System


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Your money is very important to you.
We understand that you would like to ensure the financial security of your families, that you do not wish to have money worries in retirement and that you would like both your income and your capital to work hard for you.
We also understand that you do not always have enough time to deal with your financial affairs so our role is to make everything as straightforward and effortless for you as possible. By ensuring that we have a clear and thorough understanding of both your current situation and also your financial goals and ambitions, we are able to provide you with sufficient information, advice and recommendations to enable you to make qualified and relevant decisions for your future.
Our areas of expertise
Please remember that the value of your investments and any income from them can fall as well as rise and you may not get back the original amount invested.


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According to recent studies, seven out of ten men have experienced a premature ejaculation problem and sexual performance anxiety at some point in their lives.
As you can probably tell, early ejaculation is by far the most common problem that men face in bed. Despite the fact that it is really widespread though, what causes it isn't exactly clear.
While pretty much all scientists agree that it is caused by a "lethal" combination of psychological and physical factors, they tend to disagree on whether the psychological or the physical causes of premature ejaculation are more important.
What all scientists agree on though, is the fact that sexual performance anxiety is one of the most common and most important causes of early ejaculation, as well as other problems that men may face in bed. Why is that though? Let's take a detailed look:
How can stress cause premature ejaculation?
As I am sure you will have noticed, once one is done having sex, he or she feels very calm and relaxed. This is because sex is one of the methods, perhaps the most effective, that our bodies and minds use in order to get rid of stress and relax.
If one starts having sex while being stress out, whether it is work related stress or male performance anxiety, his body will do anything in its power to get rid of this sexual performance anxiety as quickly as possible, which means that the brain will give the "ejaculation command" really quickly. In other words, the more stressed you are while having sex, the faster you will reach your climax and ejaculate.
Can all forms of stress cause premature ejaculation?
The answer to that question is a definite "YES"! Most men think that the only type of stress they need to worry about during sex is performance anxiety, i.e. worrying about not being able to sexually satisfy their partner, but that is only partly true.
While male performance anxiety is definitely one of the most important causes of premature ejaculation, stress that relates to one's job or everyday life, is just as important and "destructive". To put it simply, your mind doesn't care about the causes of your stress: if you are stressed and full of anxiety, it will do everything it can to expel those negative feelings as fast as possible.
So what can I do as far as stress and lasting longer in bed are concerned?
Well the obvious answer is to get rid of your stress before you start having sex. You can do that by doing something that relaxes you before you have sex. You can also focus on your partner while having sex. Forget everything else and focus on the naked woman on your bed. If you worry about your sexual performance, try to create a relaxed and fun mood with your partner before you start having sex.
The more comfortable you feel with her, the more you will be able to delay your ejaculation. If you do happen to experience a premature ejaculation, just shrug it off or even joke about it with your partner. DON'T MAKE A BIG DEAL OUT OF IT! If you don't worry about early ejaculation, then your mind and body won't be filled with sexual performance anxiety over it.
As you can probably tell, premature ejaculation and its prevention is a very complicated issue and articles can only touch on a few very specific aspects of it. For more information on what causes early ejaculation and how to prevent it, check out Ejaculation Trainer and Ejaculation by Command. Those are the two best books on the the subject of premature ejaculation and how to last longer in bed in general and they have helped men all over the world understand and solve their sexual stamina problems.


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"Primary with the Prophet," Friend, November 2017
Primary with the Prophet
The author lives in Maryland, USA.
Sam's head felt hot. He had a runny nose. His sister Martha was sick too. Mom said Sam and Martha were too sick to go to church.
"Can we play with trucks?" Sam asked.
"Not right now," Mom said. "We are going to have our own Primary!"
"How can I have Primary without my teacher?" Sam asked.
"Who will give a talk?" Martha asked.
"I have a plan." Mom winked at them. "I can be the teacher. And I know someone very special who can give the talk."
"Who?" Sam asked.
"You'll see!" Mom said.
Sam and Martha went to Martha's room. They set up three chairs.
"Welcome to our pretend Primary," Mom said. Then they sang "I Am a Child of God" and said a prayer.
Martha chose more songs to sing. Mom told a story about Jesus. Sam and Martha colored pictures.
Sam liked their pretend Primary! But who was going to give the talk? There was nobody there except Sam, Martha, and Mom.
Finally Mom got her laptop. She put it on Martha's bed.
"Now we have a special guest. President Thomas S. Monson is here to talk to us!" Mom clicked on a video on the computer screen. President Monson started telling them a story.
Sam smiled. He liked his special Primary with the prophet!


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Hayley Carter needed a break.
The former University of North Carolina star was physically, mentally and emotionally worn down.
She had just graduated from college, was dealing with nagging injuries and was still grieving the death of her father.
"I have played tennis since I was 6 years old and I have never been burnt out before. But I was really 100 percent at that point last year," Carter said. "I was at a stage where I didn't feel like I even wanted to go and play."
Rather than traveling for tournaments, Carter decided to take a job as an assistant coach for the Oklahoma State women. She spent this past season seeing the game from a different perspective, and the experience renewed her spirit.
The seven-time ITA All-American realized she had unfinished business as a player and is returning to the court to pursue a professional career.
"I just needed time to refind the love for the game, and I didn't want to leave my tennis life with any regrets," Carter said. "I felt like if I didn't give it a full chance and a full opportunity on the tour I would have regrets in my tennis career."
Full Listings: Boys' Commits & Girls' Commits


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Early Childhood Development Exhibition opens
A 2-Day Exhibition on the theme of 'Stimulating Environment for Early Childhood Development' (ECD) began this Friday in Rawalpindi.Details
A 2-Day Exhibition on the theme of 'Stimulating Environment for Early Childhood Development' (ECD) began this Friday in Rawalpindi.
Pakistani students and faculty members head for Arizona State University under U.S.-Pakistan Centers for Advanced Studies Program
Newly renovated and expanded Lincoln Corner Islamabad opened at International Islamic University Islamabad
Pakistan's young activist and artist, Muniba Mazari, has been named as Pakistan's first female Goodwill Ambassador by UN Women
Students have explored various themes based on climate change through the arts to create a platform for education and dialogue..
US Ambassador to Pakistan David Hale and Rector NUST welcomed more than 200 alumni at 12th Annual Fulbright and Humphrey Alumni Conference
Young South Asian leaders affirm to establish a better-connected, more secure region Peace and Conflict Resolution in Islamabad
Students from Pakistan interested in the topic of Local, State, and Federal Public Policymaking are invited to apply for participation in the Study..
Australian High Commissioner Margaret Adamson farewelled 20 Pakistani professionals who have received Australia Awards Scholarship 2016
The World Science Day 2015 seminar was held in Islamabad to connect scientists and students, as well as to encourage students towards scientific education
Representatives of 19 American Universities visited Islamabad, Lahore and Karachi to promote U.S. study options for Pakistani students by visiting schools and participating in college fairs
UNESCO and the Government of Pakistan have launched "Girls' Right to Education Programme in Pakistan" to support better access, improved quality and safe learning environments for girls..
Pakistan's youth comprising of 64% of total population is facing myriad challenges and constraints in getting decent employment opportunities. Education and Employment policies
Pakistan has the potential and expertise to address its education challenges but Government needs to embrace new solutions to deliver quality education
Young students have a vital role to play in strengthening the friendship and brotherhood between Pakistan and Turkey, said Ambassador of Pakistan to Turkey Mr. Sohail Mahmood speaking at a festive "Pakistan Day" event at Middle East Technical University in Ankara.
The youngest Nobel Peace Prize winner and girls' education campaigner in Pakistan, Malala Yousafzai, now has an asteroid named after her, the Malala Fund announced through its blog on Wednesday. Dr. Amy Mainzer, astronomer at NASA's Jet Propulsion Laboratory in California, USA, named Asteroid 316201 after Malala.


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text: Hello Everyone! Here are some beautiful projects which were submitted this month into the Make It Koigu Page! While we wish we could give everyone a prize, this month the winner is Maureen! Reminder that if you have recently finished or have any Koigu projects you'd like to share to email a photo to firstname.lastname@example.com to be entered!


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South Africa's new president, Cyril Ramaphosa, is stepping up to co-chair an International Labour Organization (ILO) top-level Commission on the Future of Work . This may come to further beef up Ramaphosa's international stature as he prepares to take up the chairpersonship of the BRICS (Brazil, Russia, India, China and South Africa.
South Africa also seats in the G20, has served as a nonpermanent member of the UN Security Council and has earned a special place within the International Monetary Fund. The ILO position for Ramaphosa propels a trend.
ILO announced that Ramaphosa will co-chair the 28 member Commission on the Future of Work, together with the Prime Minister of Sweden, Stefan Löfven. The global body is assessing the rapid transformations taking place in the world of work, and identifying the key challenges and what must be done to make the future of work better and fairer.
Ramaphosa has taken up the post with enthusiasm saying "The Global Commission is grappling with one of the most important and pressing challenges of the modern global economy. If we are to improve the lives of people across the world, we need to prepare collectively for a new world of work."
ILO Director-General Guy Ryder said "I am delighted that President Ramaphosa has accepted to co-chair the Global Commission on the Future of Work . South Africa and the ILO have a very close relationship, and I am sure that the South African President will bring to the Commission's work the values of freedom and dialogue that he has defended his whole life. They are key to the future of work we want and a global economy that works for all,"
As co-chair of the Global Commission on the Future of Work, he will work with Löfven to oversee the preparation of a major report on the future of work which will be published in early 2019. The next meeting of the Commission is scheduled to take place on 15-17 May 2018 in Geneva.
Ramaphosa replaces Ameenah Gurib-Fakim, former President of the Republic of Mauritius, who resigned from her chairmanship earlier this year.