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Publications (333)683.22 Total impact
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Article: Outcomes of pediatric glioblastoma treated with adjuvant chemoradiation with temozolomide and correlation with prognostic factorsIndian journal of medical and paediatric oncology 06/2015; 36(2):99-104. DOI:10.4103/0971-5851.158838
Article: Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India[Show abstract] [Hide abstract]
ABSTRACT: Pinealoblastoma is a highly malignant embryonal tumour of the pineal region affecting children and young adults. We herein intend to report the clinical features and treatment outcome of patients of pinealoblastoma treated at our institute. Clinical data was collected by retrospective chart review from 2003-2012. Histopathology slides were reviewed, and relevant immunohistochemistry stains were done. Overall survival (OS) and recurrence-free survival (RFS) were analysed by Kaplan-Meier product-limit method. Univariate and multivariate analyses of prognostic factors were done by log rank test and Cox proportional hazard regression model, respectively. Seventeen patients met the study criterion (male:female = 11:6). Median age at presentation was 14 years (range 4-47 years). Surgical resection was gross total in 6 (35.29 %), near-total in 2 (11.76 %), sub-total in 2 (11.76 %), and limited to biopsy in 7 (41.18 %) patients. At presentation, 4 patients had leptomeningeal dissemination. Radiation therapy was delivered in all patients-craniospinal irradiation in 15 (88.24 %), whole brain irradiation in 1 (5.88 %), and whole ventricular irradiation followed by boost in 1 (5.88 %) patient. Systemic chemotherapy (median 6 cycles) was given in 14 (82.35 %) patients. The most common regimen was a combination of carboplatin and etoposide, used in 10 (58.82 %) patients. After a median follow-up of 30.3 months (mean 32.01 months), death and disease recurrences were noted in 3 (17.65 %) and 7 (41.18 %) patients. Amongst the patients with recurrent disease, 4 had spinal drop metastases and 3 had local recurrence along with spinal drop metastases. Median OS was not reached, and estimated median RFS was noted to be 5.49 years. The actuarial rates of OS and RFS at 2 years were 85.6 and 73.1 %, respectively. On univariate analysis, age more than 8 years (P = 0.0071) and M0 stage (P = 0.0483) were significant predictors of improved RFS. Age retained significance on multivariate analysis of RFS (P = 0.02932). Maximal safe resection followed by craniospinal irradiation and systemic chemotherapy with 6 cycles of carboplatin-etoposide regimen is a reasonable treatment strategy in patients of pinealoblastoma more than 8 years of age in a developing nation. However, the same strategy is less effective in younger children and innovative study designs of intensification of post-operative treatment must be explored in this age group.Child s Nervous System 06/2015; DOI:10.1007/s00381-015-2751-1 · 1.16 Impact Factor
Article: Treatment outcome and patterns of failure in patients of non-pineal supratentorial primitive neuroectodermal tumor: review of literature and clinical experience form a regional cancer center in north India[Show abstract] [Hide abstract]
ABSTRACT: Supra-tentorial primitive neuroectodermal tumors (SPNET) are high-grade, hemispheric tumors, which account for around 2-3 % of pediatric brain tumors. We herein intend to report the clinical features and treatment outcome of patients with nonpineal SPNET treated at our institute. Clinical data were collected by retrospective chart review from 2006 to 2012. Histopathology slides were reviewed, and relevant immunohistochemistry stains were done. Overall survival (OS), recurrence-free survival (RFS) and event-free survival (EFS) were analyzed by the Kaplan-Meier product-limit method. Fifteen patients met the study criterion (male: female = 2:1). Median age at presentation was 11 years (range 3-49 years). Surgical resection was gross total in 6 (40 %) and subtotal in 8 (53.33 %) patients. At presentation, two patients had leptomeningeal dissemination. Radiation therapy was delivered in 11 (73.33 %) patients: craniospinal irradiation in 8 (36 Gy/20 fractions/4 weeks to the craniospinal axis followed by a local boost of 20 Gy/10 fractions/2 weeks) and focal RT in 3 patients. Systemic chemotherapy (median 6 cycles; range 1-16 cycles), given in 13 (86.67 %) patients, included the VAC regimen (vincristine, adriamycin, cyclophosphamide) alternating with IE (ifosfamide,etoposide). After a median follow-up of 22.6 months (mean, 24.47 months), complete response and progressive disease were noted in 8 (53.33 %) and 7 (46.67 %) patients, respectively. Median OS was not reached, and estimated median EFS was noted to be 4.12 years (actuarial rate of EFS at 2 years, 55.2 %). Maximal safe resection followed by craniospinal irradiation and systemic chemotherapy with 6-12 cycles of an alternating regimen of VAC and IE is a reasonable treatment strategy in patients with nonpineal SPNET.Acta Neurochirurgica 05/2015; DOI:10.1007/s00701-015-2444-2 · 1.79 Impact Factor
Article: Genome-wide small noncoding RNA profiling of pediatric high-grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII-52 and delineates H3F3A and TP53 mutant-specific miRNAs and snoRNAs: Small noncoding RNA profiles in pediatric HGG[Show abstract] [Hide abstract]
ABSTRACT: Pediatric high grade gliomas (HGGs) are highly malignant tumors that remain incurable and relatively understudied. The crucial role of non-coding RNAs (ncRNAs) has been reported in various cancers. However, study on miRNAs in pediatric HGGs is scant and there is no report till date on status of other small ncRNAs. Genome-wide microarray analysis was performed to investigate small ncRNA expression in pediatric HGG (n=14) and compared with adult GBM signature. Validation of miRNAs and snoRNAs was done by real-time PCR. TP53 and H3F3A mutation specific miRNA and snoRNA profiles were generated and analyzed. Pediatric HGGs showed upregulation of miR-17/92 and its paralog clusters (miR106b/25 and miR-106a/363) while majority of downregulated miRNAs belonged to miR379/656 cluster (14q32). Unsupervised hierarchical clustering identified two distinct groups. Interestingly, group-2 with downregulated 14q32 cluster showed better overall survival. The miRNAs unique to pediatric HGG as compared to adult GBM were predicted to affect PDGFR and SMAD2/3 pathways. Similarities were seen between pediatric HGG and TP53 mutant miRNA profiles as compared to wild types. Several of H3F3A mutation regulated genes were found to be the targets of H3F3A mutant specific miRNAs. Remarkably, a significant downregulation of HBII-52 snoRNA cluster was found in pediatric HGGs, and was specific to H3F3A non mutants. This is first genome-wide profiling study on miRNAs and snoRNAs in pediatric HGGs with respect to H3F3A and TP53 mutations. The comparison of miRNA profiles of pediatric HGGs and adult GBM reiterates the overlaps and differences as also seen with their gene expression and methylation-signatures. This article is protected by copyright. All rights reserved. © 2014 Wiley Periodicals, Inc. © 2015 UICC.International Journal of Cancer 05/2015; DOI:10.1002/ijc.29610 · 5.01 Impact Factor
Article: SG-02 * ROLE OF mTOR SIGNALLING PATHWAY IN THE PATHOGENESIS OF SUBEPENDYMAL GIANT CELL ASTROCYTOMASNeuro-Oncology 04/2015; 17(suppl 3):iii35-iii35. DOI:10.1093/neuonc/nov061.140 · 5.29 Impact Factor
Article: Glycogen Storage Disorder due to Glycogen Branching Enzyme (GBE) Deficiency: A Diagnostic Dilemma[Show abstract] [Hide abstract]
ABSTRACT: Glycogen branching enzyme deficiency/Andersen disease can manifest with a spectrum of clinical phenotypes, making the diagnosis difficult. An 11-year-old Pakistani boy presented with a history of progressive weakness and delayed milestones. Echocardiography showed features of dilated cardiomyopathy. He was suspected to have congenital myopathy and was evaluated further. Muscle biopsy showed subsarcolemmal accumulation of basophilic material, which stained positively with Periodic acid-Schiff reagent (diastase-resistant). Ultrastructural examination revealed accumulation of structurally abnormal forms of filamentous glycogen, confirming the diagnosis as Andersen disease. As histopathological and immunohistochemical evaluation of muscle biopsies is not always diagnostic, ultrastructural examination may serve as a valuable adjunct in difficult cases.Ultrastructural Pathology 04/2015; DOI:10.3109/01913123.2015.1014612 · 1.13 Impact Factor
Article: Role of bone marrow derived pluripotent stem cells in peripheral nerve repair in adult rats: A morphometric evaluation[Show abstract] [Hide abstract]
ABSTRACT: Semi-quantitative and quantitative assessment of the effect of bone marrow-derived mononuclear cells (BM-MNC) on early and late phase of nerve regeneration in rat sciatic nerve model. Sciatic nerve transection and repair was performed in 50 inbred female Wistar albino rats divided equally in two groups. In the test group the gap was filled with BM-MNCs obtained from the two male rats and fibrin sealant, while in the control group only fibrin sealant was used. Sciatic nerve was harvested at 15 days and at 60 days interval. Parameters of regeneration were assessed at anastomosis (G), intermediate distal (C), and distal site (A). Semi-quantitative (histopathological) and quantitative (morphometric) parameters were analyzed. At 15 days there was a statistically significant difference found in mean axon diameter, mean nerve thickness and myelin thickness at the repair site (P < 0.05). However, in the distal areas, the axons were sparse and myelin rings were very thin in both the groups. At 60 days, the difference in above-mentioned parameters was statistically significant at the distal most sites. FISH assay confirmed the presence of Y chromosome, confirming the presence of BM-MNCs from the male rats. Transplanting BM-MNCS at the site of peripheral nerve injury leads to significantly better recovery. These differences were evident at the repair site and at the intermediate distal site at 15 days and at the distal most sites at 60 days. With practically no ethical issue regarding their isolation and application, they can be easily used for clinical trials.04/2015; 6(2):152-9. DOI:10.4103/0976-3147.153218
Article: A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance[Show abstract] [Hide abstract]
ABSTRACT: Hypoxia is a hallmark of solid tumors including glioblastoma (GBM). Its synergism with Notch signaling promotes progression in different cancers. However, Notch signaling exhibits pleiotropic roles and the existing literature lacks a comprehensive understanding of its perturbations under hypoxia in GBM with respect to all components of the pathway. We identified the key molecular cluster(s) characteristic of the Notch pathway response in hypoxic GBM tumors and gliomaspheres. Expression of Notch and hypoxia genes was evaluated in primary human GBM tissues by q-PCR. Clustering and statistical analyses were applied to identify the combination of hypoxia markers correlated with upregulated Notch pathway components. We found well-segregated tumor-clusters representing high and low HIF-1α/PGK1-expressors which accounted for differential expression of Notch signaling genes. In combination, a five-hypoxia marker set (HIF-1α/PGK1/VEGF/CA9/OPN) was determined as the best predictor for induction of Notch1/Dll1/Hes1/Hes6/Hey1/Hey2. Similar Notch-axis genes were activated in gliomaspheres, but not monolayer cultures, under moderate/severe hypoxia (2%/0.2% O2). Preliminary evidence suggested inverse correlation between patient survival and increased expression of constituents of the hypoxia-Notch gene signature. Together, our findings delineated the Notch-axis maximally associated with hypoxia in resected GBM, which might be prognostically relevant. Its upregulation in hypoxia-exposed gliomaspheres signify them as a better in-vitro model for studying hypoxia-Notch interactions than monolayer cultures.PLoS ONE 03/2015; 10(3):e0118201. DOI:10.1371/journal.pone.0118201 · 3.53 Impact Factor
Article: Intracranial Fungal Granulomas: A Single Instituitional Clinico-Pathological Study of 66 Patients and Review of Literature[Show abstract] [Hide abstract]
ABSTRACT: Fungal granulomas of the central nervous system are rare, and have high mortality and morbidity irrespective of treatment. The authors report their experience of managing 66 patients over 15 years and discuss the clinical, radiological, surgical and pathological findings. This is among the largest reported series. A retrospective analysis was performed on patients with intracranial fungal granulomas (ICFGs), treated in our institution, between January 1997 and May 2011. Only mass forming histopathologically proven ICFG were included in this study. The age of the patients ranged from 7 years to 67 years (mean= 32.3 yrs) and most patients were in the third and fourth decades of life. The study population had 47 males and 19 females. The most common symptom was headache (41 patients), followed by vomiting (16 patients) and blurring of vision (16 patients). Only 3 patients had fever as a presenting feature. The duration of symptoms was less than 6 months in all cases and less then 3 months in 39 cases. Anterior cranial fossa and frontal lobe was involved in 35 cases (54.5%), followed by middle cranial fossa in 20 cases (30.3%).Three cases had granulomas in CP angle. Three cases had multi-compartmental involvement and four multi-lobar involvement. Nine patients had predisposing factors for fungal infection Based on clinical and imaging data, preoperative diagnosis of a possible fungal lesion was made in 44 (some had only CT imaging) patients. All the patients were treated surgically, followed by antifungal treatment with amphotericin-B and/ fluconazole/ itraconazole for a period of six weeks. Eight patients had symptomatic recurrence of lesions 3-12 weeks after treatment and were re-operated. Six patients were lost to follow up. Nine patients died in the post-operative period (within 30 days postoperatively). Fifteen patients died during follow up due to recurrent lesions, repeat surgery, renal failure and unrelated causes. Overall mortality was 24 (36.3%). Poor neurological status before surgery, emergency craniotomy, severe brain edema with mass effect and opening of ventricles during surgery was associated with poor outcome. Aspergillus species were the causative organism in an overwhelming majority of patients (n=52) followed by Mucor in 7 cases, Cladiosporium in 3 cases, Eumycetoma in 2 cases, Maduramycosis and Blastomycosis in 1case each. ICFG have high morbidity and mortality rates. Early diagnosis, radical surgery and antifungal treatment for 6 weeks may improve outcome. Poor neurological status of patients at the time of presentation, immunocompromised state, contamination of ventricular CSF during surgery and renal failure (due to amphotericin-B) are associated with poor outcome. Copyright © 2015 Elsevier Inc. All rights reserved.World Neurosurgery 02/2015; DOI:10.1016/j.wneu.2015.01.053 · 2.42 Impact Factor
Article: Impact of intraoperative MRI on outcomes in epilepsy surgery: preliminary experience of two years[Show abstract] [Hide abstract]
ABSTRACT: Purpose. To determine the impact of intraoperative magnetic resonance imaging (iMRI) in epilepsy surgeries on the extent of surgical resection and seizure outcome along with its feasibility and limitations. Methods. Patients with pharmacoresistant epilepsy (PRE), who underwent surgeries in operating theater equipped with high-field 1.5-Tesla MRI, were evaluated for extent of resection, operative time, scanning time, pathologies, resultant extra resection, and seizure outcomes. Results. Thirty-nine patients with mean age of 18 (range: 3-65) years with PRE underwent surgical intervention. Mean duration of epilepsy was 10.2 years. Surgical interventions included tumor resection (31%), resection of focal cortical dysplasia (28%), mesial temporal lobe surgeries (18%), and disconnection surgeries (23%). iMRI alone, apart from navigation and electrophysiology, improved resection rates in 13% (5 out of 39) of these patients. In lesional group, iMRI modified operative strategy resulting in increased resections in 21% (5/23) patients. Complete resection was observed in 87% of patients. iMRI scanning time constituted 25% (mean: 72 ± 21 min) of time spent under anesthesia by the patient. Major and minor complications were observed in 2.5% and 7.5% of patients, respectively. The mean follow-up was 14 months. Favorable postoperative seizure control (Engel Classes I and II) was achieved in 85% and complete seizure freedom was achieved in 77% of patients (Engel Class IA) at 1-year follow-up. Conclusions. iMRI increases the extent of resection mainly in lesional epilepsy surgeries translating into good seizure outcomes but not found to be much beneficial in prototype mesial temporal sclerosis surgeries and disconnection surgeries.British Journal of Neurosurgery 02/2015; DOI:10.3109/02688697.2014.1003034 · 0.95 Impact Factor
Article: Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas[Show abstract] [Hide abstract]
ABSTRACT: Pediatric oligodendrogliomas (pODGs) are rare central nervous system tumors, and comparatively little is known about their molecular pathogenesis. Co-deletion of 1p/19q; and IDH1, CIC, and FUBP1 mutations, which are molecular signatures of adult oligodendrogliomas, are extremely rare in pODGs. In this report, two pODGs, one each of grade II and grade III, were evaluated using clinical, radiological, histopathologic, and follow-up methods. IDH1, TP53, CIC, H3F3A, and BRAF-V600 E mutations were analyzed by Sanger sequencing and immunohistochemical methods, and 1p/19q co-deletion was analyzed by fluorescence in situ hybridization. PDGFRA amplification, BRAF gain, intragenic duplication of FGFR-TKD, and KIAA1549-BRAF fusion (validated by Sanger sequencing) were analyzed by real-time reverse transcription PCR. Notably, both cases showed the oncogenic KIAA1549_Ex15-BRAF_Ex9 fusion transcript. Further, immunohistochemical analysis showed activation of the MAPK/ERK pathway in both of these cases. However, neither 1p/19q co-deletion; IDH1, TP53, CIC, H3F3A, nor BRAF-V600 E mutation; PDGFRA amplification; BRAF gain; nor duplication of FGFR-TKD was identified. Overall, this study highlights that pODGs can harbor the KIAA1549-BRAF fusion with aberrant MAPK/ERK signaling, and there exists an option of targeting these pathways in such patients. These results indicate that pODGs with the KIAA1549-BRAF fusion may represent a subset of this rare tumor that shares molecular and genetic features of pilocytic astrocytomas. These findings will increase our understanding of pODGs and may have clinical implications. Copyright © 2015 Elsevier Inc. All rights reserved.Cancer Genetics 02/2015; 208(3). DOI:10.1016/j.cancergen.2015.01.009 · 2.42 Impact Factor
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ABSTRACT: Mutations in H3.3-ATRX-DAXX chromatin remodeling pathway have been reported in pediatric GBMs. H3.3 (H3F3A) mutations may affect transcriptional regulation by altered global histone-methylation. Therefore, we analyzed yet partly understood global histone code (H3K-4/9/27/36) trimethylation pattern in H3F3A-ATRX mutants and wild-type. H3F3A, HIST1H3B, IDH1, ATRX, DAXX and Tp53 mutations were identified by sequencing/immunohistochemistry in 27 pediatric GBMs. Global histone-methylation H3K-4/9/27/36me3 and Polycomb-protein EZH2 expression were evaluated by immunohistochemistry. H3F3A-ATRX mutation was observed in 66.7 % (18/27) of pediatric GBMs. K27M and G34R-H3F3A mutations were found in 37 % (10/27) and 14.8 % (4/27) patients respectively. G34V-H3F3A, HIST1H3B and IDH1 mutations were absent. Notably, commonest global histone-methylation mark lost was H3K27me3 (17/25, 68 %) followed by H3K4me3 (45.5 %, 10/22) and H3K9me3 (18.2 %, 4/22). Global H3K36me3 showed no loss. Most significant observation was loss of one or more histone-trimethylation mark in 80 % (20/25) pediatric GBMs. Notably, simultaneous loss of H3K27me3 and H3K4me3 were present in 7/22 (31.8 %) of pediatric GBMs. Low expression of EZH2 was found in 12/24 (50 %) of cases. However no significant correlation of loss of histone-marks or EZH2 expression with H3F3A-ATRX mutants (loss of at least one histone-marks in 87.5 % (14/16) cases) versus wild-types (loss of at least one histone-marks in 75 % (6/8) cases) was seen. The present study highlights for the first time combinatorial loss of one or more histone-trimethylation marks associated with majority of pediatric GBMs and the finding suggests significant role of histone-code in the molecular biology that underlies pediatric GBMs. Hence therapies for patients with particular combinations of histone modifications present opportunity to design innovative patient-tailored treatment protocols.Journal of Neuro-Oncology 12/2014; 121(3). DOI:10.1007/s11060-014-1675-z · 2.79 Impact Factor
- Neurology India 11/2014; 62(6):677-9. DOI:10.4103/0028-3886.149405 · 1.08 Impact Factor
- Cancer Research 10/2014; 74(19 Supplement):2077-2077. DOI:10.1158/1538-7445.AM2014-2077 · 9.28 Impact Factor
- Cancer Research 10/2014; 74(19 Supplement):4194-4194. DOI:10.1158/1538-7445.AM2014-4194 · 9.28 Impact Factor
Article: Role of concordance between ictal-subtracted SPECT and PET in predicting long-term outcomes after epilepsy surgery[Show abstract] [Hide abstract]
ABSTRACT: Objective F-18 Fluorodeoxyglucose positron emission tomography (FDG-PET) and ictally subtracted single photon emission tomography (iSPECT) are important for localizing the epileptogenic focus. The following study analyzes the role of inter-concordance between FDG-PET and iSPECT in predicting long-term outcomes after epilepsy surgery. Methods We prospectively evaluated (January 2003-January 2008) patients undergoing surgery for temporal or extratemporal drug refractory epilepsy (DRE) who had at least a 5 years follow up. Patients with MRI and video EEG (vEEG) concordance for the seizure focus underwent iSPECT and FDG-PET. Concordance of the iSPECT and FDG-PET with each other and with the substrate (defined by MRI and vEEG) for temporal and extra-temporal epilepsies was evaluated and correlated with outcomes. Results One hundred twenty-three patients (74 males) were included in the study (mean age at time of surgery: 18.9 ± 10.41 years). The mean age of onset of seizures was 9.87 ± 8.37 years. The most common semiology was complex partial (45%). When both FDG-PET and iSPECT were concordant with each other, this translated into a (Class I Engel at 5 years) outcome of 62% for extra-temporal epilepsies (provided they were also concordant with the lesion, as defined by MRI and vEEG). This percentage was significant (p < 0.01) compared with all other situations (both FDG-PET/iSPECT not concordant to MRI/vEEG, only PET or iSPECT concordant with MRI/vEEG). This correlation was not found for the temporal epilepsies, where the MRI and vEEG were the most important prognostic parameters. In both temporal and extratemporal epilepsies the concordance of the iSPECT/FDG-PET with the MRI/vEEG correlated with a better 5-year outcome (Temporal: 70% vs 25%; Extra-temporal: 62% vs 33%; p < 0.05). Significance: Concordance between non-invasive investigation iSPECT and FDG-PET is an important predictive factor for surgical outcomes in extra-temporal epilepsy.Epilepsy Research 09/2014; 108(10). DOI:10.1016/j.eplepsyres.2014.09.024 · 2.19 Impact Factor
- Neurology India 09/2014; 62(5):543-5. DOI:10.4103/0028-3886.144456 · 1.08 Impact Factor
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ABSTRACT: Background Hypoxia is a critical aspect of the glioma microenvironment and has been associated with poor prognosis and resistance to various therapies. However, the mechanisms responsible for hypoxic survival of glioma cells remain unclear. Recent studies strongly suggest that microRNAs act as critical mediators of the hypoxic response. We thus hypothesized their prominent role in hypoxia resistance in glioblastoma (GBM) and aimed to identify those. Results With this study, we present the first detailed analysis of small RNA transcriptome of cell line U87MG, a grade IV glioma cell line, and its alteration under hypoxic condition. Based on deep sequencing and microarray data, we identify a set of hypoxia regulated microRNAs, with the miR-210-3p and its isomiRs showing highest induction in GBM cell lines U87MG and U251MG. We show miR-210-3p, miR-1275, miR-376c-3p, miR-23b-3p, miR-193a-3p and miR-145-5p to be up-regulated, while miR-92b-3p, miR-20a-5p, miR-10b-5p, miR-181a-2-3p and miR-185-5p are down-regulated by hypoxia. Interestingly, certain hypoxia-induced miRNAs are also known to be over-expressed in GBM tumors, suggesting that hypoxia may be one of the factors involved in establishing the miRNA signature of GBM. Transcription factor binding sites for Hypoxia inducible factor 1 A (HIF1A) were identified in the promoter region (5 kb upstream) of 30 hypoxia-induced miRNAs. HIF-1A over-expression and silencing studies show regulation of specific miRNAs, including miR-210-3p, to be HIF1A dependent. On the other hand, miR-210-3p leads to an increase in transcriptional activity of HIF and its target genes vascular endothelial growth factor (VEGF) and carbonic anhydrase 9 (CA9). MiR-210-3p levels were found to be high in GBM patient samples and showed good correlation with the known hypoxia markers CA9 and VEGF. We show that miR-210-3p promotes hypoxic survival and chemoresistance in GBM cells and targets a negative regulator of hypoxic response, HIF3A. Additionally, a total of 139 novel miRNAs were discovered by the analysis of deep sequencing data and three of these were found to be differentially expressed under hypoxia. Conclusions Overall, our study reveals a novel miRNA signature of hypoxia in GBM and suggests miR-210-3p to be an oncogenic player and a novel potential intrinsic marker of hypoxia in glioblastoma. Electronic supplementary material The online version of this article (doi:10.1186/1471-2164-15-686) contains supplementary material, which is available to authorized users.BMC Genomics 08/2014; 15(1):686. DOI:10.1186/1471-2164-15-686 · 4.04 Impact Factor
Article: Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation[Show abstract] [Hide abstract]
ABSTRACT: Pediatric glioblastoma multiforme (GBM) is rare, and there is a single study, a seminal discovery showing association of histone H3.3 and isocitrate dehydrogenase (IDH)1 mutation with a DNA methylation signature. The present study aims to validate these findings in an independent cohort of pediatric GBM, compare it with adult GBM, and evaluate the involvement of important functionally altered pathways.Neuro-Oncology 07/2014; 16(12). DOI:10.1093/neuonc/nou113 · 5.29 Impact Factor
Article: Evaluation of 1p and 14q status, MIB-1 labeling index and progesterone receptor immunoexpression in meningiomas: Adjuncts to histopathological grading and predictors of aggressive behavior[Show abstract] [Hide abstract]
ABSTRACT: Background: Meningiomas are benign central nervous system tumors; however, significant fraction recurs, irrespective of histological grade. Materials and Methods: We performed fluorescence in-situ hybridization for 1p36 and 14q32, and immunohistochemistry for progesterone receptor (PR), p53 and MIB-1 on 84 meningiomas. Results and Conclusion: Sixty-four were convexity tumors (30 grade I, 21 grade II, 13 grade III) and 20 petroclival (grade I; 10 with gross total resection (GTR), 10 with subtotal resection (STR)). Isolated 1p36 deletion was seen in 20% grade I, 28.6% grade II and 30.8% grade III convexity meningiomas, and isolated 14q deletion in one grade III convexity tumor. 1p/14q co-deletion was seen in none of grade I, 28.5% grade II and 30% grade III convexity meningiomas. PR immunoreactivity was less frequent in grade III tumors. Petroclival tumors did not show isolated deletion. However, 1p/14q co-deletion was seen in 20% of petroclival tumors with STR and in none with GTR. Frequency of chromosomal alterations and MIB-1 labeling index both increase with tumor grade. 1p/14q co-deletion is characteristic of grade II/III meningiomas, while PR immunoreactivity inversely correlates with grade, suggesting their use as surrogate markers for grading. Identification of 1p/14q co-deletion in grade I petroclival tumors with STR suggests that unresectable petroclival meningiomas are biologically more aggressive than their grade I convexity counterparts.Neurology India 07/2014; 62(4):376-382. DOI:10.4103/0028-3886.141248 · 1.08 Impact Factor
Top Journals
All India Institute of Medical Sciences
New Dilli, NCT, India
- • Department of Neuropathology
- • Department of Pathology
- • Department of Biochemistry
- • Department of Neurosurgery
- • Department of Neurology
AIIMS Bhopal All India Institute of Medical SciencesBhopal, Madhya Pradesh, India
University Health NetworkToronto, Ontario, Canada
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")Lutetia Parisorum, Île-de-France, France


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LeBron Praised For Role In Apatow's "Trainwreck" Going Off The Grid What I Like With ESPN's Michelle Beadle Felix Hernandez, Jerry Dipoto List Homes Executive Transactions Nike's Phil Knight Stepping Down In '16 Sources: Angels' Dipoto Out As GM SBD Readers Heading To Dead Shows Minding My Business: Orlando City's Chelsey Clifton Executive Transactions
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JACK KENT COOKE re-married his ex-wife Marlene Ramallo Saturday at his estate near Middleburg, VA (WASHINGTON POST, 7/16)....Padres Owner JOHN MOORES was profiled in the HOUSTON CHRONICLE. Moores, in Houston to receive an award for his contributions to UH, said owning a MLB franchise is exactly what he thought it would be (HOUSTON CHRONICLE, 7/16)....Devils Owner JOHN McMULLEN participated in the "CEO Forum" in Annapolis, MD. At a forum on immigration, McMullen noted that dry cleaners in urban areas "are all run by Koreans," while "thousands of unemployed blacks" live nearby. McMullen said society must convince "the unemployed blacks to do these things" (WASHINGTON POST, 7/15).

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Though nothing had been officially declared or confirmed, Randeep Hooda and Neetu Chandra had been dating each other from the middle of 2010. Randeep had even taken her home to meet his parents. However, there was trouble in paradise. In January of this year, Neetu clearly expressed her fear that
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oye lucky lucky oye title song full song 2009 oye lucky lucky oye promo new hindi movie full song 2009 Abhay Deol Neetu Chandra Archana Puran Singh Paresh Rawal starring Abhay Deol & Paresh Rawal Paresh Rawal, Neetu Chandra DIRECTOR: Dibakar Banerjee indian movie promo new bollywood...
Neetu Chandra
About a week ago, Neetu Chandra was called by film maker Ram Gopal Varma (RGV) to his Oshiwara office in Mumbai. The film maker wanted to make a film on the life of Chinese American martial artist and actor Bruce Lee. For that movie he wanted a female lead to step into the shoes of the master's h
After breaking-up with Neetu Chandra, the 'Murder 3' actor Randeep Hooda has found a new love. Rumor is abuzz that Randeep has found true love in Aditi Rao Hydari, his 'Murder 3' co-star. According to the latest grapevine, the couple has been going strong for few months but keeping low profile.&n
Latest Bollywood News
- Hema Malini injured in car collision; five-year-old girl killed
- Neeraj Pandey's 'Toilet - Ek Prem Katha' to address menace of open defecation
- Aaradhya "off limits" for public, says Abhishek
- 'Calendar Girls' teaser: Bhandarkar captures life behind fame and money
- Shahid marriage: Actor's stepmom Supriya says it's a normal wedding


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Pallekele International Cricket Stadium, Kandy ,7/3/2015, 10:00 (IST)
Old Trafford, Manchester ,6/23/2015, 23:00 (IST)
England beat New Zealand by 56 runs
Shere Bangla National Stadium, Mirpur ,6/24/2015, 14:30 (IST)
India beat Bangladesh by 77 runs
P Sara Oval, Colombo ,6/25/2015, 10:00 (IST)
Tamanna Bhatia (Tamil: தமன்னா; Telugu: తమన్న) (born December 21, 1989 in Mumbai, Maharashtra, India) is an Indian film actress and model who debuted in the Hindi film Chand Sa Roshan Chehra in the lead role. Since then, she had acted in several Tamil and Telugu language films.
Who is the hottest Telugu actress?
Baahubali is an upcoming two part Indian film, written and
Average movie rating
Average movie rating
A comedy centered around three people who each have a
Average movie rating
Tadakha, the Telugu remake of the Tamil blockbuster Vettai,
Average movie rating


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Fri, 03 Jul 2015 10:48:17 GMT
BOE lowers deposit guarantee to £75k from £85k
They've pulled the excuse that it gets reviewed every 5 years but they are using the move in the pound vs the euro to make an adjustment. The EU rules allow for €100k in protection. 5 years ago EURGBP was trading around 0.85 which is how they got £85k.
Thu, 02 Jul 2015 22:56:18 GMT
9 myths about the Greek crisis (as approved by the Greek Finance minister)
I found it through a tweet from Yanis Varoufakis, the Greek Finance Minister. Ohh ... as I write the post I am seeing a second tweet from him in which he is promoting the article again .... yep, as approved by Mr. V. Here's the article, make your own ...
Wed, 01 Jul 2015 13:11:25 GMT
Southampton FC
Saints welcome OctaFX as Official Forex Partner
Southampton FC
OctaFX uses the most up-to-date technology and knowledge to make the forex trading experience incredibly convenient by aiming to set the superior standard of service and maintain them to the highest level, while constantly developing new services and ...


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St. Michael Military Medallion
Roll over image to zoom in
Your favorite service member deserves a medal. Our faith-affirming St. Michael medallion offers a prayer for protection and bears the imprint of the wearer's particular branch of service. A must-have for Catholics and others of faith in the military. Proudly made in the U.S.A.
- Air Force, Army, Marines, or Navy
- Pewter
- Reads: "Protect Us" on one side with military insignia on reverse
- Pendant: 0.75" dia. (1.9 cm)
Pewter chain: 24" L (61 cm)
- Made in the U.S.A.
For bulk pricing on these and other items, please contact our Customer Service department at email@example.com.
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May 30, 2015 - This is a beautiful medallion! I am very happy with the size and quality of the item. I bought the Marine medallion for my neighbor's son who will be inducted into the Marine Corp in September. I am sure he will love it.
February 1, 2015 - I am a Marine Corps veteran living in AZ. I ordered this for my daughter, who is currently in the U.S. Army. She was just stationed in Germany for the next 2 years. We have a very close relationship, and she's certainly "Daddy's girl." Since she is on her own for the first time, in a foreign country, I wanted her to have the same protection/comfort from St. Michael that I felt when I served. This certainly hit the Mark. The online pictures do not do this product justice. I am considering buying additional ones for myself, and relatives that are also veterans. Thank you for a wonderful necklace that can be worn everyday and then passed down as a keepsake!!
December 16, 2014 - Bought this for my husband. Had no problem slipping the chain over his head. He loves it!
June 30, 2014 - Son bought for Dad as a father's day gift, and Dad like it very much. Only problem with it is the chain is too short to go over Dad's head and there is no clasp to open the chain. Will have to get a longer chain so Dad can wear it.
June 16, 2014 - great for anyone
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Use the firm but tacky stage of ICE Resin to add layers within bezels.
Use ICE Resin to add sand to a glass bottle
The Man From U.N.C.L.E. has traveled from American TV to our 'Zine and will be on the Big Screen
The sunny skies and blue waters of Venice are the backdrop for this thrilling necklace.
Wood cuts under ICE Resin come together perfectly in this bejeweled homage to The Man from U.N.C.L.E. by Heather Widener.
Watch her make it:
Nix Bubbles – Humid Summers or Wet Winters
Wet winters and humid summers………….
Bubbles can be caused by a variety of factors including humidity and mixing.
When you mix the Part A Resin with the Part B hardener be sure to mix it slowly, folding the parts together and scraping the sides.
Air bubbles can be caused when you use a sealant on an object or a piece of paper but do not allow the sealer to dry long enough. A bezel or found object can have surface humidity on it from the climate of the room you are working in. You can use a blow dryer on bare metal for about 20 seconds first to eliminate this kind of humidity.
ICE Resin plungers and bottle caps are airtight and as long as they are screwed on completely, will not allow humidity into the container. When working with the bottles, be sure to replace the red tops onto the nozzles to keep it airtight as you store it.
Lord of the Rings inspired staff with a lit up ICE Resin crystal
The written instructions for this staff live HERE.keep looking »


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My name is Mikael, and I am a scientist/engineer working with acoustics. =
have used Audacity a lot for mixing sounds of different kinds, but have
used other proprietary software for analysis such as A-weighted levels,
octave band levels and so on. But I have realized that using a Nyquist
plug-in such an analysis would be a simple thing to add to Audacity.
However, I quickly reached the point were I got stuck, and hence I=92m
sending this mail to ask for help.
I would like to filter a signal in my Nyquist plugin with a set of digita=
filter coefficients (often called =93a=94 and =93b=94 coefficients). This=
must be
possible in Nyquist, since all the filters use this approach, but I have
found no way of directly giving values for the coefficients a and b. All =
can find in the Nyquist documentation and the source code of other
plug-ins is filter functions where you give transition frequencies and
such, and then the low level stuff including calculating the coefficients
gets done automagically.
Beeing more specific: I have two different filters I would like to
implement, one being the A-weighting filter (see
http://en.wikipedia.org/wiki/A-weighting). I have made a bilinear
approximation which uses five =93a=94 and seven =93b=94 coefficients, how=
can I
filter a signal with these home-made coefficients in Nyquist?


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Olympiakos 2 Manchester United 0: Michael Carrick remains optimistic despite dismal defeat - 'United can still turn tie around'
England midfielder remains upbeat despite woeful United performance
Wednesday 26 February 2014
Michael Carrick insisted Manchester United still had hope of progressing in the Champions League after they slumped to a 2-0 first-leg defeat to Olympiakos in Athens with one of their worst performances of a desperately trying season.
"It's a disappointing night. We feel like we are still in with a chance going back to Old Trafford but it won't be easy," Carrick said.
"We've lost a game. We came here hoping to win but we are not out of the tie. It's not ideal.
Alejandro Dominguez gave Olympiakos the lead seven minutes before half time when he flicked Ioannis Maniatis' shot from the edge of the penalty area to leave David de Gea wrongfooted. Nine minutes into the second half, Joel Campbell, on loan at the Greek club from Arsenal, was given too much time outside the box to beat De Gea with a curling 20-yard shot.
Read more: 'United can still turn tie around,' claims Carrick
Comment: Excuses running out for Moyes after grim defeat
Keane fumes - even about the post-match interviews
Match report
That's the worst United have played in Europe - Moyes
United scarcely created a chance all night until Robin van Persie fired over from an excellent position with nine minutes to go. Their defence was tentative and error-prone while Tom Cleverly and Carrick were off the pace in central midfield.
"We had good possession in the first half without penetrating through their lines but at the same time they didn't cause us any problems," Carrick added. The goals came from nothing really.
"We didn't start the second half well and that put us on the back foot. We are not getting results and as players we have to take that on the chin."
Commenting on the game for ITV, former United captain Roy Keane said David Moyes' side "just did not turn up." He added: "Nobody predicted that. It's been a tough night for the club, the players and the fans."
Forget elongated limbs and saucer-like eyes, one evolutionary biologist thinks he knows what aliens will look like
Latest in Sport
Sport blogs
England vs Japan: Watch the moment Laura Bassett's own goal saw England knocked out of the 2015 Women's World Cup
Bastian Schweinsteiger to Manchester United: Bayern Munich coach Pep Guardiola hints midfielder will be leaving the club this summer
Morgan Schneiderlin to Manchester United: Transfer news live - Robin van Persie to leave, Saints and Tottenham battle for Toby Alderweireld
Wojciech Szczesny was 'lied to' by Arsene Wenger over future after £11m transfer of Chelsea goalkeeper Petr Cech
Football kits 2015/16: The good, the bad and the downright worst new shirts from around the world for next season
- 1 iPhone 7 (or iPhone 6S) leaked pictures show similarities to older model — but Apple is fixing the biggest issue of all
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The moment a Queen's Guard soldier lost it and drew his gun at annoying tourist
Greece crisis: IMF was pushed around by Angela Merkel and Nicholas Sarkozy – and now it is being humiliated
'I wish the BBC would stop calling it Islamic State' – David Cameron unleashes frustration at broadcaster
Greece crisis: The wider lesson is that it's time to abandon this failed experiment in currencies
Girl, 7, stares down hate preacher at Ohio festival with pro-LGBT rainbow flag gesture
Forget little green men – aliens will look like humans, says Cambridge University evolution expert


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Gunmetal Black Ep 01
episode 14.25 / 5.00 4,114 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.23 / 5.00 12,959 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.16 / 5.00 11,899 Views
"So rockmusic IS from hell?"
Funny, but everytime something explode, why is´nt there a "boom"sound?
To the guy before me
SlimGuy, uh.....I'm pretty sure everyone, even bhuddist monks, knows about it. And I hate it too. Too damn repetetive.
Holy Hell
You know about home star runner? holy shit, i didnt know anybody knew about that exept me! crazy! but uhh home star runner sux dude, they dont make sense.
sweet stuff....
yeah, the only thing i didn't like was the fluctuation of sound, i had to turn the volume up whenever the devil spoke just so i could here him. it was real funny but i didn't get the end, they were in hell then suddenly they were on earth, then the microwave thing happenned and they were in hell suddenly. i love your series.
That was funny as hell, man. One thing though, that satan's voice relly got on my nerves, i dont know y, but it was really starting to get on my nerves. but other than that, it was awesome


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Tequila Sunrise: Rivera's Spanish Cuisine
Wednesday, March 25, 2009 | 6 years ago
Rivera, a sleek new restaurant a few steps from Staples Center, is the new culinary home of John Rivera Sedlar. It is a good place to stop for an elegant dinner or a few tapas after a Lakers game, for a proper cocktail flavored with fresh chiles and maybe ground grasshoppers, or just a shot of mezcal. Read Jonathan Gold's "Rivera, John Sedlar�s Return to the Kitchen."
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Missoula, MT (Sports Network) - Kareem Jamar had 20 points, Will Cherry scored 18 and the Montana Grizzlies edged the Weber State Wildcats, 67-64, to repeat as Big Sky Tournament champions.
The top-seeded Grizzlies (25-6) found themselves in a familiar place Saturday night. Montana played in the conference title game for the fourth straight season, and for the third time, defeated Weber State (26-6) with an automatic bid to the NCAA Tournament on the line.
"It was an unbelievable success when you look how far this team has come and everything they've dealt with," Montana coach Wayne Tinkle said. "Never have they let us down. Every time they were challenged, they responded."
Even at 34-34 after 20 minutes, the game remained a back-and-forth affair.
A three-point play by Jamar put Montana up 59-54 with about three minutes remaining. Weber State's Davion Berry then drew a foul on a drive in the lane after hitting a 3-pointer. Berry, though, missed both free throw attempts and then committed an offensive foul for his fifth personal, ending his night.
With under a minute to play, Cherry drained a 3-pointer to give the Grizzlies a 62-57 lead. Frank Otis answered with a layup for second-seeded Weber State, which began to foul.
Jordan Gregory sank two free throws to restore a five-point Montana lead with 22 seconds to play.
The Wildcats refused to go away as Gelaun Wheelwright's deep 3-pointer whittled down the deficit to two.
Cherry was quickly fouled and he made both free throws with 10.1 seconds left.
Joel Bolomboy closed the gap to 66-64 with a putback of Jordan Richardson's missed 3-pointer, but only 2.7 seconds remained. After Mike Weisner connected on 1-of-2 from the charity stripe, Weber State was unable to heave a would-be game-tying 3-point try.
"This one's hard, It hurts because our kids invested in our program and invested in each other. It's painful," Weber State coach Randy Rahe said.
Gregory had 12 points ... Berry, Bolomboy and Scott Bamforth each logged 12
points for Weber State ... The loss snapped the Wildcats' 13-game winning
Former Heisman Trophy winners Matt Leinart, Eric Crouch and Rashaan Salaam are among 76 Football Bowl Subdivision players on the ballot for election into the 2016 class of the College Football Hall of Fame.
The regular season in the NASCAR Sprint Cup Series has reached its midpoint, with 13 races completed and 13 to go before the championship Chase begins.
The Houston Texans have signed defensive lineman Brandon Deaderick, who played last season with the New Orleans Saints.
The Toronto Blue Jays activated catcher Dioner Navarro from the 15-day disabled list following a 2-0 loss to the Washington Nationals in the opener of Tuesday's doubleheader.
Sacramento Kings forward Carl Landry underwent surgery on Tuesday to repair a torn ligament in his right wrist, the team said.
The Montreal Canadiens revealed on Tuesday that defenseman Jeff Petry has agreed to terms on a six-year contract extension.


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Catskills + Hudson Valley
Catskills + Hudson Valley Travel Guide
You'll never wonder what to do in the Hudson Valley because the area is so rich with culture and art. Whether you'd prefer to explore outside or relax inside, the options are endless.
Nyack is one city that you won't want to miss. Located in an old Dutch farming community, the area offers many trendy boutiques, galleries, antique shops, and ethnic restaurants giving Nyack something of a Greenwich Village feel. Art-lovers looking for things to do in the Hudson Valley will be happy to find that Edward Hopper, a 20th-century painter, grew up here. Visit his home, now known as the Edward Hopper House Art Center, which contains details about his life and serves as an exhibit space for other artists.
Lovers of the great outdoors wondering what to do in the Hudson Valley should look no further than Devil's Path. The ominously named hiking trail is known for being the toughest hike on the East Coast. Those hiking the trail will find waterfalls, slippery walks and possibly bears on the 25-mile trek.
One of the most fun things to do in the Hudson Valley is catch a show at the Fisher Center for the Performing Arts. Located on the Bard College campus, this cultural center hosts a wide variety of events from art installations to musical performances.
an ice cream spot that's especially Beware long lines at this icecream store; it's especially popular after the nearby multiplex lets out. Sweetest of all: friendly service and retro prices ($1 for a kiddie cone, $3 for a brownie sundae).
Less than 90 minutes from Manhattan's Fifth Avenue, savvy shoppers can find the same branded merchandise at up to 65 percent off, thanks to this 220-strong ultra-luxe outlet hub.
The 1948 post–Art Deco cinema in Callicoon, NY, charges a mere $5 a seat for matinees.
The Beaux-Arts Vanderbilt Mansion crowns a 212-acre parkland with river panoramas.
Housed in several beautifully laid out barns, converted into a museum space in 1950, is the world's premier collection of Shaker artifacts and archives, though the site itself had nothing to do with the Shakers.
Rodgers has more than 50,000 items, including record albums in mint condition, crammed into every cranny of the place and guarded by a sleepy spaniel.
Offseason, hike the ski runs to see the entire yellow and bronze valley below.


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New Beauty And The Beast Episode 16,Season 1 Official Spoilers,Synopsis Released By CW
New Beauty And The Beast episode 16,season 1 official spoilers,synopsis released by CW. Recently, CW revealed the new,official,synopsis/spoilers for their upcoming "Beauty and The Beast" episode 16 of season 1, and it sounds pretty interesting when Vincent gets framed, Tess and Catherine's relationship gets forever changed,and more. The episode is called, "Insatiable."
In the new episode 16 press release, after taking their relationship to a new level, Catherine and Vincent will be forced to deal with reality when someone appears to be framing the vigilante. Evan is going to find proof that Catherine knows more than she is letting on about the beast.
Muirfield and the police will be closing in on Vincent ,and this time, there is no escape, so J.T. (Austin Basis) and Catherine will come up with an extreme solution. Meanwhile, Tess will follow a tip,and finds something that will forever change her relationship with Catherine.
Brian White also stars. Lee Rose directed the episode, written by Blair Singer. Episode 16 is scheduled to air on Thursday night,March 21st at 8pm central time on CW. Follow us on Facebook by Clicking Here. Follow us on Twitter by Clicking Here.Did You Enjoy this Post? Subscribe to Hollywood Hills on Facebook, Twitter, & Email
Recent Posts from On The Flix:
- New James Bond Spectre Day Of The Dead Featurette Movie Clip Released
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- Outlander Season 2 Evil Jack Randall's Younger Brother To Arrive,New Spoiler
- New Under The Dome Season 3,Official Episodes 1 & 2 Spoiler Photos Hit The Net


text:
Search megsc's books
Random books from megsc's library
The Poetry of Robert Frost: The Collected Poems, Complete and Unabridged (Owl Book) by Robert Frost
The Satanic Verses: A Novel (Bestselling Backlist) by Salman Rushdie
Campo Santo by Winfried Georg Sebald
The Classical World: An Epic History from Homer to Hadrian by Robin Lane Fox
Wild Swans: Three Daughters of China by Jung Chang
Best Russian Short Stories : The Uncensored Edition by Thomas Seltzer
Exhibited by Candlelight: Sources and Developments in the Gothic Tradition (D Q R Studies in Literature) by Valeria Tinkler-Villani
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- FIRESTONE® DESTINATION A/TDESTINATION A/T All Season / All Terrain Tires by Firestone®. This is the SUV and light truck all-terrain tire for drivers who want to go wherever the road leads - from main streets to the woods. The Destination A/T with UNI-T...
$148.75from $119.00 - $332.00 (ea)# 1075355
- FIRESTONE® DESTINATION M/TDESTINATION M/T All Season / All Terrain Tires by Firestone®. The Destination M/T is the first Firestone light truck tire with exclusive UNI-T technology to advance wet handling and braking. Plus, you get a whole package of...
$231.25from $185.00 - $338.00 (ea)# 1075480


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UEN News & Notables
Now Showing on UEN-TV
Fons & Porter's Love of Quilting
Flower Bed - Construction of a "circular" design, is created from the simple "building blocks" of 9-patch units and rectangles. Marianne and Mary stress cutting accuracy and a consistent quarter inch seam for the success of creating this...
Now Showing on MHz Worldview
Euronews Newscast
PROGRAM NOTE: EuroNews AM Newscast on MHz Worldview will move to 5AM ET weekdays beginning November 1st.
A unique view on world events. News every 30 minutes, distributed by EuroNews.
For more information about...


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Fee, fi, fo, fum, I smell dickgirls!
Visiting this forum is like walking in on your grandma and grandpa having sex.
I blame you for everything wrong with the world.
I want two penises.
It's never a bad time to read erotic stories!
Lowtax has a huge dickgirl fetish. We jump on the couch and put in a good dickgirl porn and masturbate each other while eating Funyons.
Lowtax's teeth glow in the dark.
We are family!
Doesn't Mulan become a man in that movie? Figures.
He was ripped off for True Detective, now Thomas Ligotti is being asked to review Pizza Hut's new Hotdog Pizza Bites.
Harry Potter and friends are returning in a new trilogy of films. Get your wizard hats ready and find out who will be back and which fan favorites may be introduced to the screen.
Check out some of the finest images this site has ever seen, Scottish-soccer-related or otherwise!
Everyone, meet Party Egg! He's the egg who parties so hard he scrambles himself inside his shell.
Marty Sickle and the gang try to solve the mystery of the spooky haunted porn factory, bro!
There are hundreds of stories happening on the World Wide Web. Let me tell you, that's a very wide web. Our goal at Weekend Web is to bring you the latest headlines from around the Internet. We go into the very bowels of message boards everywhere and find out what millions of online citizens have to say.
Copyright ©2015 Rich "Lowtax" Kyanka & Something Awful LLC.


text:
View Singles in Riceville
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Keystone State of Pennsylvania. Whether you're searching for casual Pennsylvania dating or serious Pennsylvania relationships, Match.com has millions of smart, sexy and attractive singles meant just for you. It's the perfect way to see who is single in Riceville, what we're all about, and it's free. Love works miracles every day - so does Match.com in Riceville. Every year, hundreds of thousands of people find love on Match.com.
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text:
Start > Texas - TX > Collin County > Plano
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Therapists in Plano
Verified by Psychology Today
Renee Segler-Dather
"You work hard to have a happy life, but it feels like you are running in circles going nowhere...... and your unhappy. Let us work together to identify what "road blocks" are standing in the way of a fulfilling and meaningful life.
(972) 829-0533
Verified by Psychology Today
Jennifer Jenkins
Counselor, MS, LPC-S, RPT-S
"I am a Licensed Professional Counselor in private practice. I am also a Licensed Counselor Supervisor and Registered Play Therapy Supervisor. I earned my Masters of Science degree at the University of North Texas, and received advanced training in Play Therapy, Expressive Arts and Filial Therapy. I have more than 15 years of experience working with children and families, including addressing the psychotherapeutic needs of women with postpartum depression, grandparents raising their grandchildren, pre-adolescents and adolescents, and families who have experienced the death of a loved one. I also specialize in working with pre-school age children and their parents.
(972) 893-9467
Verified by Psychology Today
Kenneth Eugene Eubank
Counselor, Lpc
"Do you suffer from loneliness, hopelessness, loneliness, isolation, discouragement , don't know what to expect in life? Have you lost your passion for life, have you lost your motivation, do fear and anxiety have you paralyzed? Are you stuck in a job or a relationship, stuck in a bad mood, are you angry or anxious most of the time, apathetic about your life, do you struggle with negativity or a bad attitude, wish you could have a more positive outlook? Do you wonder what your purpose is? Do you have difficulty accepting yourself?
(214) 666-5415
Verified by Psychology Today
Lana M Bagley
Counselor, MA, LPC
"I work with adolescents, stressed out college students, adults and couples. My specialties include managing difficult life situations, self-esteem issues, anxiety, depression, autism spectrum disorders, eating disorders, grief, and coping with terminal illness. I use an Integrative Approach, which includes Cognitive Behavioral, Client centered, Solution focus and faith based techniques.
(972) 810-7633
Verified by Psychology Today
Lauren Kellersman
Clinical Social Work/Therapist, LCSW
"I am passionate about working with children, parents, and families to help improve overall quality of life and functioning within your family and community. Specifically, much of my clinical work focuses on family issues, career goals, interpersonal relationship building, coping with depression and anxiety, as well adults with a history of childhood trauma/abuse.
(214) 516-7034
Plano, Texas 75023
Verified by Psychology Today
Lu Whipple
Counselor, MA, LPC, LPC-S
"Anxiety? Depression? Life problems? I am here to help and to congratulate you. You have just taken the first step toward making changes toward a more balanced life. Therapy is a process where you can learn to identify, and to use, the strengths that you already have, to clarify your issues, to gain insight, and to find practical solutions and options that are right for you.
(972) 665-7214
Verified by Psychology Today
Rachel Oppenheimer
Psychologist, PsyD
"I have experience and enjoy working with individuals impacted by autism spectrum disorders. In addition to offering therapeutic services to individuals and family members, I also work with children and adults in social skills groups, as well as provide evaluations for autism spectrum and other psychological disorders. My aim is to help clients with social skills, self-esteem, insight, perspective taking, and increased quality of life.
(972) 810-7623
Verified by Psychology Today
Erin Crandall
Counselor, MS, LPC
"I am passionate about helping adolescents, adults, and couples in reaching their full potential and succeed in meeting their life goals. I specialize in working with people who are going through life transitions, including grief/loss, education/career change, chronic pain/illness, or family changes. I believe that clients possess strengths within them to succeed. However, when unexpected life changes occur, stress can cloud one's ability to find solutions. In those instances, people sometimes need additional tools and help to overcome problems.
(817) 381-3871
Verified by Psychology Today
Yu Harumi
Psychologist, PhD
"It takes a lot of strength and courage to acknowledge that you need help for coping with challenges that life brings to you. As a psychologist who values compassion, non-judgmental and affirming attitude, and strength-based approach to clients, I would like to commend you for taking that difficult first step, and to thank you for visiting my profile and website. I provide individual and couples counseling, career / personal / executive coaching, consultations and workshop presentations to clients from diverse national origins, ethnic groups, gender and sexual orientation, religious / spiritual orientation, age groups, and socioeconomic and ability status.
(469) 454-2636
Verified by Psychology Today
Michelle Shannon
Counselor, MA, LPC, Intern
"I believe Life's ups and downs give depth to the meaning of life. At times our unique rhythms may become unbalanced and if yours does, counseling may be able to help. Counseling can help you identify thoughts and behaviors in life that have not served you well and replace them with positive productive ones, guide your focus to your strengths, process difficult emotions, and problem solve so you may move forward in life. You can become empowered to restore your own balance. It may require some hard work, but both you and a happy life are worth it!
(469) 789-1274
Verified by Psychology Today
Stephen Chock
Psychologist, PhD
"http://www.chariscounseling.net My Goal: to promote mental, physical, & spiritual health for people at each developmental level or personal phase of life. Your struggles might include depression, existential crises, or inefficient brain functioning. I have a broad range of experience. Studied at Ohio State University under top-ranked professors in Counseling Psychology. Pre-PhD internships: Minneapolis VAMC and Ohio State's brain injury unit. Have 17+ years inpatient rehab neuropsychology experience at Baylor Hospital Dallas. Spent 5 years doing Christian counseling at the Minirth-Meier Clinic & teach counseling at Dallas Theological Seminary.
(469) 804-7893
Plano, Texas 75023
Verified by Psychology Today
Kris White
Clinical Social Work/Therapist, LCSW, LMFT
"Intimacy is often impeded by an inability to know your self or to see yourself accurately. Often we loose that sense of self in relationships which then promotes agitation and depression. We then take on addictive behaviors to avoid feeling reality. Difficulties in childhood often does not equip us with the skills of boundaries which is the only thing that helps to maintain a sense of who we are while remaining connected in a relationship. I can help you develop the skills of being relational and still be you.
(972) 916-9190 x2
Verified by Psychology Today
Kristin Goodwin
Counselor, MS, LPC, CEDS
"Kristin has experience working with a variety of populations including depression, anxiety, adjustment disorders, PTSD, addictions, domestic violence and sexual assault. Primarily, her focus is on issues related to adult and adolescents struggling with eating disorders, body image concerns and low-self-esteem.
(972) 330-2497
Verified by Psychology Today
Dolores Guilliod
Counselor, MA, LPC
"In one's walk towards wholeness and change, there are various barriers and hindrances one must overcome. The prism in which we view life, the messages we received about ourselves from our family of origin, what has happened to us and what we tell ourselves about it, our fear of feelings, and our learned coping mechanisms, are just a few. As a counselor, it is my desire to provide a safe and accepting environment in which we can walk and work together to expose, understand, and overcome these barriers.
(214) 317-4458
Verified by Psychology Today
Zahra Negheen Payravian
LPC Intern, MS, LPC-I
"At times life gets so hard and challenging, to follow through the right pass, but you are not alone, and the only one, who experiences the hardship of the life. The key is to step in the solution journey, and not trying to absorb the pain all by yourself. The base of my counseling and therapy approaches is caring about your feelings and emotions, while I try to stay with you in your hurting and painful moments of your life. This approach let you resolve the pain and move on throughout your life journey in the best way possible for yourself.
(469) 437-4605
Verified by Psychology Today
Ruby Bouie Johnson
Drug & Alcohol Counselor, LMSW, LCDC, SAP, CSAT-C
"Working with clients who are impacted by addiction has been a passion of mine for 14 years. I have worked with the individual, the spouses/partners, and family. The identified addict needs a comprehensive treatment approach the considers resources with the community, support system, and practical therapeutic approaches that focus on life skills. The addict is "growing up in public" which can be lonely, scary, frustrating, and confusing. I offer empathy and positive regard without judgment and preconceived notions about who they are.
(469) 518-2960
Verified by Psychology Today
Access Counseling Group
Treatment Facility
"At Access Counseling Group, we know that people have different needs and come to us in various stages of the recovery process. Our goal is to identify and tailor a program to meet each individuals needs. Access Counseling Group offers individual counseling, family counseling, intensive outpatient counseling, and partial hospitalization programs for adults and adolescents. On Saturdays, we also provide support groups for community members who are effected by substance use; for more information please see below. We are a provider of offender education classes. Weekend and evening hours are available.
(972) 360-9422
Verified by Psychology Today
Jillissa Christine Cherepon
Counselor, MA, LPC
"Counseling has been Jillissa's passion for years. She specializes in, but is not limited to, issues including: marriage and family, relationship dynamics, boundary issues, adolescent and children's issues, and woman's issues such as eating disorders, depression, anger, anxiety, divorce care, singleness, grief, bitterness, identity and significance issues and mood disorders. She also works with clients struggling with anxiety disorders including Generalized Anxiety Disorder, Post Traumatic Stress Disorder, Obsessive Compulsive Disorder and Adjustment Disorders. Jillissa's philosophy of counseling is the integration of Christianity and psychology, and her counseling methods include: Cognitive-Behavioral Therapy, Family Systems Theory, Psychoeducation, and Child Play Therapy.
(972) 200-3409
Verified by Psychology Today
Paulette R Rollins
Counselor, LPC, NCC
"Paulette can guide you in your journey to overcome depression, reduce anxiety, manage stress, increase self esteem, save your marriage, solve relationship problems, improve communication skills, and make life-altering changes. Paulette is a skilled therapist who can help you through your difficulties She views counseling as a cooperative effort between client and therapist that can result in life altering changes. Some changes can be achieved in a short time and some require more work. Counseling can help! Don't suffer in silence anymore. Help is just a phone call away.
(214) 427-1156
Verified by Psychology Today
Robert Pine
Counselor, MS, LPC, MTS
"Welcome to Hills and Valleys Counseling! "Parent of the Year" awards should be given to mothers and fathers of children and teens who suffer serious emotional and behavioral difficulties. Some of these troublesome behaviors include explosive anger, rapid and extreme mood changes, constant irritability, high-alert anxiety, can't-get-out-of-bed depression and out-of-control hour-long meltdowns. Not only does the child suffer, but the whole family suffers. As a parent, along with my wife, we have been there when our son was a child, teen and young adult (he died as an adult).
(469) 209-4093
Not enough Therapists to choose from?
Try expanding your search for Therapists in Plano to a larger area (e.g. Collin County, Texas)
How can I tell if a therapist is right for me?
Therapists in Plano have broad skills and are able to work with a wide range of issues.
For example, if you're seeking a marriage counselor in Plano you'll find that most therapists are trained in marriage counseling or couples counseling in Plano and couples therapy. And they welcome families for family counseling in Plano or family therapy in Plano.
What method of therapy is right for me?
When it comes to treatment methods, there's no "right way". A couples counselor or a family counselor may use different treatment methods depending on the one that works best for you.
How to use my insurance?
Many therapists accept health insurance. Check to see if your insurance is covered. Feel free to discuss this when you contact the therapist.


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PODS® to Host "Spring Into Cleaning With PODS®" Contest
Kicking off on Monday, March 3, KYSR-FM listeners can enter the "Spring into Cleaning with PODS" contest on the KYSR website for a chance to win a Container Store Gift Card valued at $1,000 and three months of storage from PODS®
(LOS ANGELES, Calif.), March 4, 2014 - (PressReleasePoint) - PODS® Los Angeles and KYSR-FM will encourage listeners to get a jumpstart on their spring cleaning this year. Kicking off on Monday, March 3, KYSR-FM listeners can enter the "Spring into Cleaning with PODS" contest on the KYSR website for a chance to win a Container Store Gift Card valued at $1,000 and three months of storage from PODS®, The Best Moving & Storage Idea Ever™.
"We're very excited to be involved with KYSR-FM 'Spring into Cleaning with PODS' contest," said PODS® Los Angeles manager Mark DuBose. "We enjoy being part of a fun giveaway to help a family in Los Angeles eliminate the clutter in their homes by providing them with the best storage solution."
You must enter to win by Monday, March 31st.
To learn more about the contest, visit www.ALT987FM.com.
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More Videos...
Falcon Futura 10.5 Outlaw debut - George Bastiras
George Bastiras won the 10.5 Outlaw class at Calder Park's APSA meeting. The twin turbo Ford was only on very low Boost but still dipped into the 7-second zone. http://www.facebook.com/fullBoostcomau http://www.youtube.com/user/fullBoostcomau http://www.fullBoost.com.au Creative Commons license Music: Severed Fifth http://www.severedfifth.com/
2600hp Ford Falcon??? The DIRTY BIRD
One badass bird! This 1968 Ford Falcon running on 275 Drag Radials lays down around 2600hp through its 449ci Small Block Ford with a pair of 88mm turbos, watch it tear down the track at the North Star Dragaway x275 race.
1963 Ford Falcon - Falconstein
From the 2011 Lakewood, Ohio Car Kulture Show.
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Pro Street Ford Falcons & some of my Own Cars


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SCARSDALE, N.Y. – A Scarsdale woman was arrested late on Thursday night, June 19, after concerned residents alerted police to a motorist driving erratically near the intersection of Fox Meadow Road and Wayside Lane.
According to police, residents spotted a woman driving her Chevrolet convertible dangerously at 10:30 p.m. in the area before police responded to the vehicle, which was then stopped and parked in the area.
In his report, Officer Steven Delbene said that when he approached the vehicle, he detected "a strong odor of an alcoholic beverage," which the suspect, Lisa Pierdiluca, 54, confirmed when she produced a 750 milliliter bottle of Jack Daniels Tennessee Honey Whiskey that was missing approximately three quarters of its contents.
During his discussion with Pierdiluca, Delbene, "observed her to have bloodshot, glassy eyes," and she "was heavily slurring her speech when she spoke." According to the report, the suspect may have fallen asleep at one point while being questioned by officers on the scene.
When she got out of her vehicle to attempt a field sobriety test, police said that she was stumbling badly and needed to be held up to prevent her from falling to the pavement, and during the tests, she couldn't stand upright without dramatically swaying.
After failing the field sobriety tests, Pierdiluca was placed under arrest and charged with misdemeanor counts of driving while intoxicated and aggravated driving while intoxicated because her blood alcohol content was .21 percent, which is more than double the legal limit of 0.08 percent.
The suspect is due back in Scarsdale Village Court on Wednesday, June 25.
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Gunmetal Black Ep 01
episode 14.23 / 5.00 3,885 Views
Lucina's First Day
A look at the first day of Lucina in Super Smash4.23 / 5.00 12,112 Views
BATMAN v SUPERMAN final showdown
SPOILERS!!4.16 / 5.00 11,112 Views
Awwww, i love old people.
I didn't get it..
But, I cannot give this a low score for some odd reason. It was well animated, the sounds went well, and I could tell a good deal of effort was put into on this. I have a question for you, what was the joke? Unfortunately, I am only 14 and know little about old jokes.
Old joke...still funny its even better now that somebody put this joke to animation... good job
Thats so classic :)
Very very funny, haha I big kick in the ass for that old guy. I would do the same thing except maybe add a few years ;P
Amazing. Are you?
Man it's really hard to find such graphics as this, amazing! I bet all my points that you really worked really hard to do such a funny and amazing video like this. And i actualy never heard thi joke before, so it makes it beter (:-P). I hope to see more Amazing Flash Movies from you(what am i saying? I know you are going to make beter Flash Movies!) A big way to go man, keept up the good work. It was good, Dang It...
-=[GE] Specialist=-
Thank you, Specialist-G3
I spend most of my free time making animations.
Its really nice to hear from people like you who enjoy my work.


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*Former Detroit Mayor Kwame Kilpatrick is facing up to 20 years in prison after he was convicted Monday of most of the federal charges against him in his public corruption case, including racketeering, extortion and filing false tax returns.
Kilpatrick is accused of running a criminal enterprise through the mayor's office to enrich himself through bid-rigging and extortion, and using nonprofit funds for personal gain.
After 14 full days of deliberation, the jury reached a unanimous decision on 40 of 45 counts against Kilpatrick and Bobby Ferguson. No verdict was reached on the charges of racketeering against Bernard Kilpatrick.
Breaking with typical protocol, the verdict was not read by the jury foreperson. Instead, Judge Nancy Edmunds read the verdicts herself.
The panel of eight women and four men deliberated for close to 100 hours before finally reaching their decisions. The verdict was reached on Friday. The jury decided to go home and sleep on it over the weekend to see if anyone would change his or her mind by Monday morning.
The prosecution wants Kwame Kilpatrick and Ferguson in custody immediately. The judge will decide that during a 1:30 p.m. meeting. The prosecution believes they are flight risks.
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West Monroe has 22 schools. Some of the best schools in West Monroe are Claiborne School with a GreatSchools rating of 10/10 and a parent rating of 5/5 stars, and George Welch Elementary School with a GreatSchools rating of 10/10 and a parent rating of 5/5 stars. The average GreatSchools rating for West Monroe public schools is 7/10, with an average student/teacher ratio of 15:1.
School data provided by National Center for Education Statistics, Maponics, and GreatSchools. Intended for reference only. GreatSchools Ratings compare a schools test performance to statewide results. To verify enrollment eligibility, contact the school or district directly.
The supply of housing inventory exceeds demand. Buyers have the advantage over sellers due to the abundance of homes on the market, with homes often selling at reduced prices. Price drops are common as sellers compete to find buyers.
Not enough data to determine market type. Consult a local REALTOR® for up-to-date market summaries
Trend data coming soon.
Trend data coming soon.
|For Sale: 312
|New: 41
|Recently Sold: 281
|Reduced: 122
|Average Home Price
|Average Sold Price
|Property Records: 20,500
|Foreclosed: N/A
The average home price in West Monroe is $199,934, which is 29.3% higher than the average sold price in West Monroe ($154,647) . The average home price per square foot in West Monroe is $98 and about 1% of all homes in West Monroe sold in the last 6 months. For West Monroe home values, real estate prices, and city market trends, research the 20,500 property records or search our 281 recently sold or 312 homes for sale listings. The listings and properties in West Monroe are only a part of the 1,489,094 properties and 18,916 homes for sale in Louisiana. Because of this, the average home price and average home value of West Monroe also influence the average home price $245,000 and average sale price $191,974 of Louisiana. Listing counts, West Monroe home prices and home values in West Monroe are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.
|Median Age
|Median Household Income


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What travellers think
Travellers that stayed here think this hostel is best for
- Sightseeing
- Culture
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In a superb location just around the corner from the most popular streets in the city, and only 15 minutes' walk from the Old Town.
Travellers that stayed here think this hostel is best for
Staff really helpful, very good the guest kitchen, excellent quality price!
Tue 13 Jan 2015
Tatamka hostel was clean and recentrly remodeled. Its location is very convenient, close to the Old Town, the City Center and major sites, such as the Chopin Museum and the Kopernikus Science Center. The staff was helpful, although a bit "grumpy", like most of the people I encountered in Poland. All in all, I had a pleasant experience and I would definitely recommend it for its location. I can't say however that it has special character or atmosphere.
Sat 22 Nov 2014
Room with no courtains and to much noise ....solution from the reception was giving us bed shits to put on the windows and for noise offer sometinhd to put in the ears ....nice people ;-) was not far to the center
Sat 15 Nov 2014
Staff were quite dismissive upon arrival. I wasn't offered a towel, but noticed upon departing that free towels were available. Internet was almost non existent in my room and at best intermittent with very poor signal. Lockers are so flimsy that anyone would be able to open them with a screwdriver. The location of the hostel is is the middle of nowhere in a dark, lonely part of the city where it doesn't feel safe.
Wed 05 Nov 2014
It wad a plessure!!! beautifull and comftable! the location is awsome and the hotel people are kind and nice!!! totally the perfect hostel!
Wed 24 Sep 2014


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StoryThe Mars Exploration Project was destroyed by an alien attack in 2039. Seven years later, the UN is launching a deep space mission in search for the aliens. Mikako and Noboru have just finished tests, and are going to high school... or so was the plan. Mikako is drafted as a pilot for the UN mission, separating them. When she goes to space, their only communication is by e-mail, which takes longer and longer to arrive as the UN ships travel out of the solar system. Will their love survive the distance and void of space?
|Makoto Shinkai
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Just a Shadowadded 30 new screenshots
Mar 30, 07 4:55pm
- Genre: Anime Movies
- Theme(s): Anime, Sci-Fi (Futuristic)
- Director: Makoto Shinkai
- Producer: A.D. Vision
- Length: 90
DVD Release North America Jun 10, 2003 Japan Apr 19, 2002


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Fourth of July is the height of the beer-drinking season. Here are six beer suggestions for your barbecue.» Read More
As David Letterman says good-bye on air, today's top 10 Market Cap Companies that did not exist as publicly traded companies when he debuted on February 1, 1982.
Her marriage to Nelson Rockefeller soon after both had been divorced raised a political storm and may have cost him the GOP presidential nomination.
Nintendo may have just made the greatest hire in the history of hires.
A Norwegian Cruise Line ship ran aground on a reef after leaving Bermuda but no one was injured and the vessel was later floated off at high tide.
Nascar driver Jimmie Johnson is partnering with Mission and Lowe's to focus on heat safety, as the summer starts to kick off.
Nasty Gal didn't skip a beat when it spotted Taylor Swift wearing its jumpsuit. The only problem? She was wearing Balmain.
The Navy has a new drone for spying that is small, cheap and completely disposable.
Part of what makes "Shark Tank" great is its unscripted quality. A look at 10 surprising things that end up on the cutting-room floor.
What's old is new again at fast food chain Kentucky Fried Chicken.
"I'm not Don Draper," said Bill Backer, the man behind the "I'd Like to Buy the World a Coke" ad, the NYT reports.
George Lucas probably isn't regretting the deal he made with Disney for his Lucasfilm group after shares rise 70 percent.
Most parents plan to support their kids financially for at least a few months after college, a Upromise survey found. But can you afford to help?
Markets underestimate liquidity risks, which look more dangerous than Greece's debt situation, the Allianz economic advisor said.
The Tesla P85D was effectively rendered undriveable, Consumer Reports says in a blog post.
For online lingerie start-up Adore Me, crowdsourcing its product ideas on social media turned into a $6-million-dollar idea.
A cautionary "Simpsons" and "Star Trek" analogy pretty much sums up the power of behavioral economics, says the founding father of the discipline.
Some sports cars have stood the test of time and become truly iconic. Check out CNBC.com's definitive collection.
Golden Bear, the maker of Letterman's "Late Show" staff jackets for over 15 years, will miss the king of late-night TV when he retires.
After seven seasons, "Mad Men" is over. The question now is: did fans buy the series finale?
More than one-third of employers around the world are experiencing difficulty filling job positions, global employment consultancy Manpower reported on Monday.


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Exclusive Photos: Irrational Man
In Woody Allen's latest, Joaquin Phoenix stars as a tormented philosophy professor who finds the will to live when he commits an existential act. Check out exclusive photos from the film and behind-the-scenes, exclusively on IMDb.
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Indie Focus: Amy
Watch a 14-year old Amy Winehouse serenade her friend with a lovely rendition of "Happy Birthday" and get a glimpse of the girl behind the name in this incredible and eye-opening portrait.
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The third season of "Masters of Sex" jumps forward to 1966, the dawn of the sexual revolution, as Masters and Johnson takes their research on the road. "Masters of Sex" premieres on Showtime on Sunday, July 12th.
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Manglehorn, Kumiko, the Treasure Hunter, The Wrecking Crew, and more recent movies are available on Amazon Instant Video.


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DARIEN, Conn. -- A 16-year-old Darien boy told police he was assaulted outside his home on Leeds Lane last week, according to police.
The teen told police he was home alone shortly before 11 p.m. Friday, June 6, when he saw someone walking around the exterior of the house. He grabbed a baseball bat and went to investigate, police said.
After checking the front and side yards, the teen went to the backyard, where somebody pushed him from behind, according to police reports. He hit his head on a stone wall and was dazed for a few minutes, he told police.
The person who pushed him was described as 6 feet tall and wearing dark clothing, police said. The teen told police that his attacker did not say anything before or after pushing him.
The teen sustained minor scrapes to his right cheek and forehead but refused medical treatment, police said.
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