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The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint
ABSTRACT Activation of the anaphase-promoting complex/cyclosome (APC/C) by Cdc20 is critical for the metaphase-anaphase transition. APC/C-Cdc20 is required for polyubiquitination and degradation of securin and cyclin B at anaphase onset. The spindle assembly checkpoint delays APC/C-Cdc20 activation until all kinetochores attach to mitotic spindles. In this study, we demonstrate that a HECT (homologous to the E6-AP carboxyl terminus) ubiquitin ligase, Smurf2, is required for the spindle checkpoint. Smurf2 localizes to the centrosome, mitotic midbody, and centromeres. Smurf2 depletion or the expression of a catalytically inactive Smurf2 results in misaligned and lagging chromosomes, premature anaphase onset, and defective cytokinesis. Smurf2 inactivation prevents nocodazole-treated cells from accumulating cyclin B and securin and prometaphase arrest. The silencing of Cdc20 in Smurf2-depleted cells restores mitotic accumulation of cyclin B and securin. Smurf2 depletion results in enhanced polyubiquitination and degradation of Mad2, a critical checkpoint effector. Mad2 is mislocalized in Smurf2-depleted cells, suggesting that Smurf2 regulates the localization and stability of Mad2. These data indicate that Smurf2 is a novel mitotic regulator.
Full-textDOI: · Available from: Gerald H Thomsen, Jun 19, 2015
- SourceAvailable from: Dipankar Ray[Show abstract] [Hide abstract]
ABSTRACT: Epidermal growth factor receptor (EGFR) is overexpressed in a variety of epithelial tumors and is considered to be an important therapeutic target. Although gene amplification is responsible for EGFR overexpression in certain human malignancies including lung and head and neck cancers, additional molecular mechanisms are likely. Here, we report a novel interaction of EGFR with an HECT-type ubiquitin ligase SMURF2, which can ubiquitinate, but stabilize EGFR by protecting it from c-Cbl-mediated degradation. Conversely, small interfering RNA (siRNA)-mediated knockdown of SMURF2 destabilized EGFR, induced an autophagic response and reduced the clonogenic survival of EGFR-expressing cancer cell lines, with minimal effects on EGFR-negative cancer cells, normal fibroblasts, and normal epithelial cells. UMSCC74B head and neck squamous cancer cells, which form aggressive tumors in nude mice, significantly lost in vivo tumor-forming ability on siRNA-mediated SMURF2 knockdown. Gene expression microarray data from 443 lung adenocarcinoma patients, and tissue microarray data from 67 such patients, showed a strong correlation of expression between EGFR and SMURF2 at the messenger RNA and protein levels, respectively. Our findings suggest that SMURF2-mediated protective ubiquitination of EGFR may be responsible for EGFR overexpression in certain tumors and support targeting SMURF2-EGFR interaction as a novel therapeutic approach in treating EGFR-addicted tumors.Neoplasia (New York, N.Y.) 07/2011; 13(7):570-8. DOI:10.1593/neo.11632 · 5.40 Impact Factor
Article: The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation[Show abstract] [Hide abstract]
ABSTRACT: The multi-functional adaptor protein NEDD9/HEF1/Cas-L regulates cell motility, invasion and cell cycle progression, and plays key roles in cancer progression and metastasis. NEDD9 is localized to the centrosome and is required for activation of Aurora A kinase in mitosis. Here we demonstrate that the HECT-WW protein Smurf2 physically associates with NEDD9 and is required for the stability of NEDD9 protein. Smurf2 depletion results in a marked decrease in NEDD9 protein levels, by facilitating polyubiquitination and proteasomal degradation of NEDD9. Conversely, forced overexpression of Smurf2 results in upregulation of endogenous NEDD9 protein, confirming the role for Smurf2 in NEDD9 stability. Cells with Smurf2 depletion fail to activate Aurora A at the G2/M boundary, leading to a marked delay in mitotic entry. These observations suggest that the stable complex of Smurf2 and NEDD9 is required for timely entry into mitosis via Aurora A activation.Cell Division 09/2010; 5:22. DOI:10.1186/1747-1028-5-22 · 2.63 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications. For example, the timely polyubiquitination of critical mitotic regulators by Anaphase Promoting Complex/Cyclosome (APC/C) is essential for the metaphase to anaphase transition and mitotic exit. The spindle assembly checkpoint prevents unscheduled activity of APC/C-Cdc20 in early mitosis, allowing bipolar attachment of kinetochores to mitotic spindle and facilitating equal segregation of sister chromatids. The critical effector of the spindle checkpoint, Mitotic arrest deficient 2 (Mad2), is recruited to unattached kinetochores forming a complex with other regulatory proteins to efficiently and cooperatively inhibit APC/C-Cdc20. A weakened and/or dysfunctional spindle checkpoint has been linked to the development of genomic instability in both cell culture and animal models, and evidence suggests that aberrant regulation of the spindle checkpoint plays a critical role in human carcinogenesis. Recent studies have illuminated a network of both degradative and non-degradative ubiquitination events that regulate the metaphase to anaphase transition and mitotic exit. Within this context, our recent work showed that the HECT (Homologous to E6-AP C-terminus)-family E3 ligase Smurf2 (Smad specific ubiquitin regulatory factor 2), known as a negative regulator of transforming growth factor-beta (TGF-beta) signaling, is required for a functional spindle checkpoint by promoting the functional localization and stability of Mad2. Here we discuss putative models explaining the role of Smurf2 as a new regulator in the spindle checkpoint. The dynamic mitotic localization of Smurf2 to the centrosome and other critical mitotic structures provides implications about mitotic checkpoint control dependent on various ubiquitination events. Finally, deregulated Smurf2 activity may contribute to carcinogenesis by perturbed mitotic control.Cell Division 02/2009; 4:14. DOI:10.1186/1747-1028-4-14 · 2.63 Impact Factor


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Northstar Ratings are powered by Northstar Travel Media and are based on objective and unbiased evaluations from experienced editors that individually analyze, research, and evaluate hotels. Hotels and suppliers are not required to pay any fees or pay for memberships to have their property rated.
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Located in the West End of Historic Alexandria, Virginia, adjacent to the Dept. of Defense (DoD) Mark Center Facility. From presentations to celebrations, our newly renovated 55,000 sq. feet of event space features a 10,200 sq. foot Plaza Ballroom, 37 total breakout rooms, private dining, and three...
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The newly renovated Hilton Alexandria Mark Center's 55,000 square feet of meeting space was enhanced with new carpet, wall and window coverings and regional artwork. The lobby was redesigned to encourage guests to recharge themselves, laptops and cell phones, using a soothing palette of blues, neutral tones and warm wood accents that give the public spaces an elegant feel. Our guestrooms compliment our lobby by using the same lush color palette of calming blues and neutrals with warm wood tones…a harmonious balance to the already beautiful setting.
With a unique lakeside setting, adjacent to a 43-acre botanical preserve, Hilton Alexandria Mark Center provides a tranquil oasis for business and leisure travelers to the Washington, DC area. From the moment you enter the towering glass atrium and Italian marble clad lobby, you will enjoy the warm greetings of our courteous staff and are assured a memorable stay.
Hilton Alexandria Mark Center Hotel delivers a refreshing hotel experience. . .
·Finn & Porter - Classic Steak & Seafood Restaurant and Sushi Bar
·High-Tech Business Center with fax, copy & print
·55,000 Square Feet of Flexible Meeting & Conference Space
·10,200 Square Foot Plaza Ballroom
·Three Permanent Board Rooms
·Executive Meeting Center & Private Retreat Rooms
·Full Service Catering, Meetings, and Convention Management
·Lobby Lounge – A cozy spot for enjoying an evening cocktail
·In Room Dining - Your Room/Suite is transformed into a private dining room
Prefunction Space Outside Main Ballroom (located on the lower level)
Located outside Magnolia Ballroom on the upper level
Located accross from hotel lobby bar and Magnolia Ballroom
Alexandria, VA
Conveniently located just blocks from the US Capitol and Union Station, The Liaison Capitol Hill offers a contemporary, chic atmosphere with a celebrity chef-owned restaurant, seasonal rooftop pool and bar, and a creative and enthusiastic event team.
The Hilton Crystal City Hotel at Ronald Reagan Washington National Airport is located within minutes of downtown Washington D.C., Historic Alexandria, Georgetown and the Pentagon.
Condé Nast Traveler: Hot List Hotels 2010! Next to the White House, W DC WOWS guests with world-class accommodations and Whatever/Whenever® service and is home to the city's most coveted rooftop views from POV rooftop lounge and terrace.


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Very good Doctor.
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Tony Boffa's Restaurant
Italian · $$
75 Railroad Ave
"Excellent meatballs and reasonably priced"
Jade Buffet
Chinese · $
203 Dolson Ave. (at Abe Isseks Dr.)
"Don't overlook this fabulous little buffet joint on Dolson Avenue. Most of the buffet is chinese, but there are also other options such as sliced meats, garlic bread, corn on the cob, etc"
Downtown Bagels
Bagels · $
157 Dolson Ave (Campbell plaza)
"Best bagels in the lower Hudson Valley."
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Because you're free to read this blog
- July 2nd - I cycled home in steady, warm rain - but the... July 2, 2015
- July 2nd - In Darlaston, a gentle precipitation; sweet-smelling,... July 2, 2015
- July 1st - Also on the canal, near Bentley Mill Way, flowering... July 2, 2015
- July 1st - The Pleck swans were cool in the heat this morning,... July 2, 2015
- June 30th - Looking almost frosted on the warmest day of the... July 1, 2015
- June 30th - There's a Matt Smith fan in Darlaston - what else... July 1, 2015
- June 29th - Intrigued and saddened to see the Four Crosses pub... June 30, 2015
- June 29th - I'm loving the orchids this year - they seem to have... June 29, 2015
- faz0la: I saw this friendly chap in the garden of a cottage I... June 29, 2015
- faz0la: My post morning jog view. June 29, 2015
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- June 28th - Feeling better, and a trundle to Brownhills... June 29, 2015
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Tag Archives: W Owen
Persistence of memory
Yesterday, whilst wandering past the former Warreners Arms pub, I stopped to look at the old inn. The condition of this landmark building continues to degrade, and the busy car wash formerly operating there now seems to have closed. I … Continue reading
Posted in Brownhills stuff, Environment, Fun stuff to see and do, Interesting photos, Local History, Shared media, Shared memories Tagged Abraham Greenhough, Brownhills, Brownhills High Street, Brownhills local history, Car Wash, Derelict, Dicky Dorsett, F Kerr, G Hammonds, Graffiti, H Seedhouse, Harry Woodhouse, J Hammonds, J Humphries, JH Owen, Local History, McWarreners, New Photos, Ogley Road, old grafitti, Pubs, Redevelopment, Riar Hicklin, Sue Lote, Vandalism, W Dorsett, W Owen, Warreners Arms 31 Comments


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Chandler Lawson may not have won the Talent Award at Tuesday's first round of Miss America preliminaries, but Tennessee's representative in Las Vegas was presented with the Duke of Edinburgh Bronze medal.
The Tullahoma native and graduate of UTC was one of 13 recipients of the award which is the nation's leading youth development program which is now in partnership with the Miss America Organization. The award is based on community service, physical fitness and personal interest development.
Miss Oklahoma Alicia Clifton, who holds the world record for tap dancing pirouettes, took the top prize in talent with her high energy routine to the Michael Buble version of "Can't Buy Me Love." The swimsuit competition was won by Miss South Carolina Ali Rogers.
Ms. Lawson sang Adele's "Turning Tables" dressed in an ice blue gown. She will compete in the on-stage question segment in tonight's second round of preliminaries.
On Thursday, she could become the first Miss Tennessee to win the coveted Quality of Life Award for exceptional community service. Ms. Lawson is one of seven finalists for the honor and the winner receives a $6,000 scholarship.
She is already guaranteed a minimum $3,000 scholarship by being a national Miss America finalist. Ms. Lawson will be attending the University Of Tennessee School Of Law once her year of service as Miss Tennessee concludes in June.
July 2, 2015
July 1, 2015
The city of East Ridge has postponed the scheduled Camp Jordan Jams on Friday and rescheduled for Aug 1, due to the possibility of inclement weather. Parks and Recreation Director Stump ... (click for more)
Options are plentiful for having some music related fun this 4 th of July weekend in the Chattanooga area. Starting Thursday, July 2 nd , Collegedale will host a celebration with the East Tennessee ... (click for more)
"Monomath," a new installment in the Greater Chattanooga series, premieres online on Wednesday, and will introduce the public to the layered, complex sounds of three talented ... (click for more)
The city of East Ridge has postponed the scheduled Camp Jordan Jams on Friday and rescheduled for Aug 1, due to the possibility of inclement weather. Parks and Recreation Director Stump Martin said there was too much of an investment made in the summer version of the Camp Jordan Jams to take a chance. "Interim City Manager Mike Williams and I decided this is what's ... (click for more)
Options are plentiful for having some music related fun this 4 th of July weekend in the Chattanooga area. Starting Thursday, July 2 nd , Collegedale will host a celebration with the East Tennessee Symphony Orchestra playing at 6:45 p.m. and fireworks to follow at dark. Local food options will be available at the celebration. The celebration is scheduled for Veterans Memorial Park, ... (click for more)
The Council on American-Islamic Relations (CAIR), the nation's largest Muslim civil rights and advocacy organization, on Saturday questioned the release of a Signal Mountain man who admitted to planning what it called "a Charleston-style terror attack" on a Muslim community in New York. CAIR also called for stepped up protection for the community targeted in the plot. Judge ... (click for more)
Several plumbers on Thursday brought complaints to a committee of the Hamilton County Water and Wastewater Treatment Authority (WWTA) and got little response other than being told that new contracts are ready. Kay Keefe of Keefe Plumbing said the small number of plumbing companies still participating in the program to repair leaky lines to homes, have long been operating without ... (click for more)
I confess that this year I am having a hard time with the idea of celebrating the 4th of July Independence Day. It is not because I am not thankful to God for what was done on that day, what it represents, and the blessings I've experienced that flow from it. On the other hand, I want to think that maybe this year's celebration will mark a period in our history in which a new movement ... (click for more)
One week from tomorrow the most important educator in the future of our community will start work as the new president of Chattanooga State. While I am normally cynical of beard-strokers and foundation-hungry dreamers who have little or no concept of the real world, I am convinced Flora Tydings will become the best thing to happen in our community in years. A grandmother with ... (click for more)


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How to Be Healthy and Active This 4th of July
Independence Day is often celebrated with fireworks, pool parties, and cookouts laden with high-carb foods. But you can stick to your low carb diet—and squeeze in some exercise—this 4th of July by following Atkins' tips for a healthy and active holiday. Eat Bring a nutritious low carb dish… Read More
How to Stay Cool in the Summer
After the first day of summer officially rolls around, many people blast the air-conditioning to combat soaring temperatures. But there are a few alternative ways to beat the heat without cranking the A/C. Read on for Atkins' 10 tips on how to stay cool this summer. Make friends with your… Read More
What to Do on Father's Day
Wondering what to do on Father's Day? We've rounded up a list of outdoorsy outings for the entire family. Celebrate the #1 Dad in your life with one of these Father's Day activities. Ride Bikes Go for a leisurely bike ride with the man who first taught you… Read More
Low Carb Veggie Recipes for Eat Your Vegetables Day
Rich with vitamins and nutrients, vegetables support overall health and reduce the risk of chronic diseases, such as diabetes and obesity. To promote incorporating this vital food group into our diets, the nation celebrates Eat Your Vegetables Day every June 17. Revisit eating the recommended serving of vegetables with a few… Read More
Celebrating National Dairy Month
Milk, cheese, yogurt, and other dairy products contain essential nutrients including calcium, protein, potassium, and vitamin D. To promote this food group, the National Dairy Council made June National Dairy Month. This month, celebrate our nation's dairy producers while eating right with low carb dairy recipes. Ham and Swiss… Read More
Low Carb Sides for Summer Barbeques
Burgers with fries and hot dogs with chips are two classic summer pairings. But if you plan to commit to your low carb diet this summer, a side of fries or chips can throw you off-track. Instead, enjoy your summer barbeque while staying healthy with a selection of low carb… Read More
Low Carb Hamburger Recipes for Memorial Day
Memorial Day Low Carb Burgers Whether you're planning a party with friends and neighbors or just having a small dinner with the family, nothing beats grilling burgers outside for everyone. Just because it's a holiday doesn't mean you have to stray from your low carb diet. Prepare… Read More
Summer Diet: Get Ready for Bikini Season
The first day of summer is just around the corner – time to get fit and feel good about your "bikini body." To prepare to impress, you first have to find the perfect summer body diet that works for you. It's easy to be active when the weather gets nicer, but… Read More
Atkins 40™: An Easy, Flexible Diet
Searching for a successful weight loss solution that doesn't take over your life can be tough. Between counting calories and squeezing in exercise, it's often hard to find the time and discipline to lose weight. Atkins 40 ™ makes it easy with a flexible diet plan that encourages weight loss through living… Read More
10 Tips for Weight Loss
Set S.M.A.R.T. resolutions. "Lose weight" may be one of the most popular goals, but make sure your "lose weight" goal is Specific, Measurable, Attainable, Realistic and Timely. Here's an example: I want to lose 24 pounds in three months by following Atkins. I will track my progress… Read More


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How did three Danes end up being tortured in Lebanon?
What a crisis has done to the people of Greece
18 Dec 2013 16:23 GMT | Sport, Football
The European Union has opened legal proceedings into whether Real Madrid, Barcelona and five other Spanish clubs get an unfair edge from illegal state aid.EU Competition Commissioner Joaquin Almunia said that clubs should use sound financial management rather than live "at the expense of the taxpayer."Almunia's office must make sure businesses across the 28-country EU face a level playing field. The probe is intended to see if teams like Barca and Real have been relying on illegal aid to face other Spanish clubs, and European teams like Bayern Munich in the Champions League.
The Commission has concerns that these measures provided significant advantages to the beneficiary clubs to the detriment of the clubs which have to operate without such support.
Statement by the European Commission for Competition
Beyond the top two teams, the probe centers on Valencia, Hercules, Elche, Athletic Bilbao and Osasuna.The Spanish government, who knew the probe was coming, has already said there was nothing illegal about the aid the clubs received. Foreign Minister Jose Manuel Garcia-Margallo said the government would "give battle until the end to defend Spanish clubs."La Liga is one of the toughest professional leagues in the world and any EU decision could have a deep impact on its future. The investigation may take several months and any decision could then be challenged at the EU's highest court in Luxembourg.Many Spanish league clubs already face financial difficulties. A decision to force them to return money could make their problems even more acute."The Commission has concerns that these measures provided significant advantages to the beneficiary clubs to the detriment of the clubs which have to operate without such support,'' the Commission said in a statement.No financial figures were immediately available but the objections the EU was looking into centre on how clubs and local authorities handled fiscal issues such as loan guarantees, land prices and real estate.The Spanish league has said in a statement that it "wants to publicly show its unconditional and absolute support for the clubs and affiliated managing institutions in general and those under investigation in particular."
Source: Al Jazeera and agencies
Real Madrid have few worries going into final Champions League group match as activists interrupt press conference.
Sport, Football, Russia
Board will decide whether to expand current stadium or build a new 105,000-seater home next month.
Sport, Football
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Changing climate, unpredictable rains dry out the land, threaten the pastoral way of life in Somaliland.
Poverty & Development, Environment, Africa
Tensions rise as Greeks from both side of the bailout debate take to the streets to withdraw money and express angst.
Politics, Europe, Greece
The world's biggest producer and consumer of the metal sees a golden opportunity to expand its pricing power.
Business & Economy, Asia, China
Normalised Cuba-US relations could result in a hybrid economic model blending socialism and entrepreneurial spirit.
Business & Economy, Communism, Politics
Voters to decide whether or not to accept creditors' proposals for more austerity in exchange for rescue loans.
Politics, Europe, Greece, European Union
Essebsi declares state of emergency after beach massacre, saying country is 'in a state of war' due to continued threat.
War & Conflict, ISIL, Tunisia, Middle East
An inside look at the devastating impact of the Greek financial crisis on ordinary citizens.
Business & Economy, Europe, Greece
Can Afghan archaeologists take on the Chinese and the Taliban to save a 5,000-year-old archaeological site?
Arts & Culture, Asia, Afghanistan
In war-torn Afghanistan it is not the Taliban that poses the greatest threat to women - it is their own families.
Human Rights, Women, Afghanistan
After decades of tension and hostility between the two nations, has change finally come to US-Cuba relations?


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Lyon, Frankfurt set for final – UEFA Women's Champions League highlights
Apr 23, 2012, 3:10 PM EDT
The favorites advanced from this weekend's semifinals, setting the stage for May 17th's UEFA Women's Champions League final in Munich.
Defending champions Olympique Lyonnais, who went into Sunday's second leg in Potsdam with a 5-1 lead, played out a 0-0 draw, eliminating 2009-10 champions (and Frauen Bundesliga-leading) Turbine.
They'll play three-time champions FFC Frankfurt (otherwise known as USWNT standout Ali Krieger's place of recovery), who finished their elimination of Arsenal with a 2-0 home win on Saturday, seeing out the Lady Gunners with a 4-1 aggregate victory.
As holders and steamrollers of one of last year's finalists, Lyon will be favored in Munich despite Frankfurt's home country advantage. If OL truly has a case to be made as the best women's teams we've seen, they have a show to put on next month.
Highlights: Turbine Potsdam vs. Lyon
Highlights: Frankfurt vs. Arsenal
Thursday's Transfer Rumor Roundup: Pogba to Barcelona, Ramos to Manchester United
Jul 2, 2015, 1:40 PM EDT
The latest gossip is right here, with updates on two monster transfers.
Mark Sampson: "England achieved things no one thought we could"
Jul 2, 2015, 1:04 PM EDT
England's head coach was full of pride and admiration for his team despite falling at the semifinal hurdle.
Clint Dempsey replaced by Michael Bradley as USMNT captain for Gold Cup
Jul 2, 2015, 11:57 AM EDT
Kilnsmann reveals he has decided to take the armband off Clint and hand it to Bradley.
Despite devastating World Cup exit, England's women inspired a nation
Jul 2, 2015, 10:25 AM EDT
Describing the scene from England, as the Lionesses helped to inspire a nation this summer in Canada.
Report: Abou Diaby heading to MLS, FC Dallas after Arsenal release
Jul 2, 2015, 9:23 AM EDT
French international is reportedly mulling over an offer from FCD. What do we think about this?
Huge blow for Mexico: Javier Hernandez breaks collarbone, out of 2015 Gold Cup
Jul 2, 2015, 8:47 AM EDT
Manchester United's "Chicharito" will not play for El Tri this summer after being injured in a friendly.
US ask Switzerland to extradite seven FIFA officials
Jul 2, 2015, 7:40 AM EDT
The U.S. Department of Justice wants to bring FIFA officials accused of corruption to the USA.
Round 3: USA-Japan Women's World Cup final a familiar matchup
Jul 2, 2015, 12:59 AM EDT
Japan beat the U.S. to win the 2011 World Cup. The U.S. beat Japan to win the 2012 Olympics. Round 3 takes place Sunday in the 2015 Women's World Cup final.
Lamar Hunt U.S. Open Cup roundup: Dwyer bags four, RBNY top Cosmos, quarterfinals set
Jul 2, 2015, 12:28 AM EDT
A Major League Soccer franchise is going to win the 2015 Lamar Hunt U.S. Open Cup.
"She's in a hard place": England boss Sampson consoles, praises Bassett after semifinal loss
Jul 1, 2015, 11:57 PM EDT
Mark Sampson spoke in detail about the character of Laura Bassett and how he hopes girls in England are inspired for the future.
Bassett's long journey takes cruel twist, but England women show future is bright
Jul 1, 2015, 11:11 PM EDT
Full credit to England for an inspiring World Cup, and to Japan for getting to a second straight World Cup final.
Clavicle injury could cost Mexico's Javier "Chicharito" Hernandez his Gold Cup (video)
Jul 1, 2015, 10:51 PM EDT
Three weeks from tonight are the Gold Cup semifinals, with the final on July 26 in Philadelphia.
The world wants Laura Bassett to know that her own goal is nothing to be ashamed of…
Jul 1, 2015, 10:11 PM EDT
From Brandi Chastain and Jeb Brovsky to total strangers from England and beyond, my goodness, people are trying to console Laura Bassett.
Minnesota United misses MLS stadium deadline; Deputy commissioner speaks out
Jul 1, 2015, 9:12 PM EDT
United says it remains committed to bringing MLS to Minnesota, and it's worth wondering if the rival Minnesota group is hampering progress.
Stoppage-time own goal sinks England, sends Japan to Women's World Cup final
Jul 1, 2015, 9:02 PM EDT
Defending champion Japan advances to second straight Women's World Cup final.
Targeted by Man Utd and other giants, Ilkay Gundogan extends deal with BVB
Jul 1, 2015, 8:20 PM EDT
Big story for Dortmund, even if it's a bit under-the-radar.
VIDEO: Donovan talks USWNT, perceived anti-Klinsmann Tweet on "The Dan Patrick Show"
Jul 1, 2015, 7:30 PM EDT
Donovan, of course, was left off the World Cup roster last summer by Klinsmann, much to the chagrin of many U.S. fans.
WATCH LIVE: Japan and England duel for World Cup final date with the USWNT
Jul 1, 2015, 6:45 PM EDT
England's fairytale run to its first Women's World Cup semifinal meets the reigning champions in Edmonton on Wednesday
Finally with New York City FC, Lampard's teammates react after first training session
Jul 1, 2015, 5:50 PM EDT
Shay Facey knows Lampard from his time at Manchester City, and wasn't bashful in praising the situation.
Top Posts
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- The world wants Laura Bassett to know that her own goal is nothing to be ashamed of… 8
- Minnesota United misses MLS stadium deadline; Deputy commissioner speaks out 2
- Stoppage-time own goal sinks England, sends Japan to Women's World Cup final 6


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Better Way to Pray: If your prayer life is not working, consider changing directions - eBook
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After 30 years of ministry, Andrew Wommack has discovered some important things about prayer including what prayer is and what it is not. You'll uncover the traditions and misconceptions in prayer and discover true and meaningful communion with God through Jesus' example of prayer. More importantly, you'll come to know a new, profound joy and fulfillment in your relationship with God, receiving the answers you need.
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|Format: DRM Free ePub
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Publication Date: 2010
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Irvin Van Patten5 Stars Out Of 5March 10, 2010Irvin Van PattenThis review was written for A Better Way to Pray: Revolutionize Your Prayer Life, Revitalize Your Relationship.Some of the best information on praying I have ever read, backed up with scripture. I recommend this book to anyone wanting to develop a true relationship. The most valuable time anyone will ever spend is in developing your communication and one on one relationship with God. This book explains how to accomplish this goal.
Monica Lucas-leflore5 Stars Out Of 5April 2, 2009Monica Lucas-lefloreThis review was written for A Better Way to Pray: Revolutionize Your Prayer Life, Revitalize Your Relationship.This book has changed my prayer life in a great way and it is very easy to understand
Carol Brown5 Stars Out Of 5May 8, 2008Carol BrownThis review was written for A Better Way to Pray: Revolutionize Your Prayer Life, Revitalize Your Relationship.It was incredible...from the first page to the last page. I inhaled every word..and sometimes I almost couldn't breath..it was so deliberate. He revealed insights that are so obvious but are overlooked in our everyday chaotic living. I thank the Lord that He revealed this depth of revelation to Andrew and that he would be so obedient to share it with us. Glory be to God!
Jeremy5 Stars Out Of 5October 8, 2007JeremyThis review was written for A Better Way to Pray: Revolutionize Your Prayer Life, Revitalize Your Relationship.Another great read. This has opened my eyes to what prayer is. If you feel bored with your prayer life, like you're never doing enough, this is a must read. Be set free in what prayer really should be.
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L.A. Metro launches crime-reporting app
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Los Angeles County transit officials yesterday unveiled a new app that allows commuters on Los Angeles County Metropolitan Transportation Authority (Metro) trains and buses to report crimes, according to the the Los Angeles Times.
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Open Day at the Archery Range
11 a.m. - 2 p.m. Charlestown
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Westerly, R.I. Monday, June 29, 2015
Open Day at the Archery Range
11 a.m. - 2 p.m. Charlestown
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WESTERLY — Westerly High's girls' volleyball team rebounded from a first-set loss to defeat Scituate Tuesday night.
After losing 25-21, the Bulldogs won the next three sets of the Division II-South match — 25-16, 25-20, 25-20.
Westerly (2-11, 2-10 Division II-South) had lost to Scituate 3-1 on Sept. 10. Scituate is now 1-11 overall and in league play.
"Serving helped, but I think it was the girls' attitude," replied Westerly coach Molly Morrone when asked the biggest factor in the match.
"They started the game with the attitude that nothing was going to hit the ground unless the girls were underneath it diving. They were digging up a lot of balls, communicating very well, and it was just a good overall for all my players."
Andrea Morrone, Lia Gabrielle and Julianna Morrone were the backbone of the back-row defense, the coach said. Megan Lacey also chipped in.
Andrea Morrone contrib uted eight digs. Lacey had six.
Lacey led the team with nine aces. Julianna Morrone had four kills and three aces.
Rachel Phelps added two aces and contributed off the bench in the pivotal third game when the Bulldogs rallied from an 18-9 deficit to win 25-20. Lacey's serving was a big factor in that game.
Westerly's next match is Thursday at Narragansett, 6:30 p.m.
WESTERLY — For the third time in four games, the Westerly High boys' soccer team had to settle for a tie.
The Bulldogs played Middletown to a 0-0 draw and got one point out of Tuesday's Division II game.
Bulldogs' coach Les Ahern said his team outplayed the Islanders (3-4-4, 3-3-4 Division II) in the first half but could not cash in on opportunities.
Westerly even had a direct- kick opportunity halfway through the second half ,but could not break through.
The Bulldogs (4-5-3, 3-5-3 Division III) outshot Middletown 10-5 and keeper Billy McCormick made three saves.
Westerly had a chance to overtake Middletown in the standings, but remained a point behind the Islanders and are currently tied with Mt. Hope for ninth in Division II with the Huskies Tuesday results not available.
Ahern said the top 12 teams from Division II qualify for the playoffs.
Next up for Westerly is a road game at Lincoln Thursday at 6:30 p.m.
East Greenwich ....................................4
Westerly ................................................2
EAST GREENWICH — Division I leader East Greenwich (9-0-1) snapped a 2-2 tie by scoring twice after the clock on the scoreboard was stopped with 2 minutes left in Tuesday's nonleague game.
Division II Westerly (5-4-2) did not trail until the final 120 seconds.
Emily Luther gave the Bulldogs a 1-0 lead 11 minutes into the first half, assisted by Brittany DeGrooth. Luther converted a short pass from DeGrooth for her fourth goal of the season. The EG goalie was protecting the post while DeGrooth had the ball. DeGrooth slid it across and Luther had a lot of net to shoot at.
The Avengers tied the score with 16:20 left in the half before DeGrooth put Westerly in front 2-1 with 8 to go before the break. DeGrooth scored her 12th goal of the season from just inside the 18 after beating a defender.
The lead held up for most of the second half, with the home team scoring the tying goal with 8:40 remaining.
East Greenwich scored the winning goal on a ball played over the top to about even with the Bulldogs' last line of defenders. Emily Sullivan came out of the net, but the Avener player kept her cool, Westerly coach Clyde Britt said, and chipped the ball over Sullivan into the net.
East Greenwich had 23 shots and four corner kicks. Westerly had nine shots.
Sullivan finished with 20 saves.
The Bulldogs return to Division II play on Thursday for a 3:45 p.m. game at Scituate.
Bulldogs drop two
NARRAGANSETT — The Bulldogs were not close in either of their losses in Monday's Southern Division meet.
Westerly lost to Narragansett 18-43 and 15-49 to the Prout School.
Sam DeSarro was 10th and finished the 2.85-mile course in 17 minutes and 54 seconds.
Justin Senior was 17th in 18:11.
Ben Calitri (25th, 19:30), Isaac Kaufman (35th, 20:49) and Rees Harold (37th, 23:16) rounded out the scorers.
Prout's Luke Emby won the race in5:48.
Prout improved to 6-2 overall and in the Southern Division and Narragansett went to 3-5 overall and in Southern Division with its split.
Westerly next runs at the Bronco Invitational on Thursday, Oct. 17 at 4:30 p.m.
O'Loughlin suit set to go to trial in September …
PROVIDENCE — A federal jury will decide whether three Westerly police officers are responsible for the 2011 death of a Mystic man who died about … more ...
School offers counseling after student death …
STONINGTON — Pawcatuck Middle School opened its doors until 7 p.m. on Thursday to offer support services to students and families after the death of … more ...
Tip leads detectives to meth lab at Wes Stor Mini …
PAWCATUCK — A three-department investigation led police to the discovery of a methamphetamine lab operating at the Wes Stor Mini Storage facility off Elmata Avenue … more ...
Former Westerly resident found guilty on child molestation charge …
A former Westerly resident who now lives in Utah was found guilty of two counts of first-degree child molestation on Wednesday after a jury trial … more ...
Helicopters called to accident …
WESTERLY — Emergency personnel and police were at the scene of a motor vehicle accident in the vicinity of Routes 1 and 78 Friday night … more ...


text:
The artificial skin that can heal itself (and could be used on fragile mobile phone screens)
- Material is the first be able to heal itself, and also sense subtle pressure
- After being cut with a scalpel, it heals close to 100% with 30 minutes
Scientists have invented the first artificial skin that can both sense subtle pressure and heal itself when torn or cut - and could one day be used for the screens on mobile phones.
A team from Stanford University are the first to create a synthetic skin that can not only repair damage to itself but is also able, crucially, to conduct electricity.
It is this crucial latter property that promises to make it useful in the field of consumer electronics.
Fragile: An Apple iPhone 4 with a smashed screen. A team from Stanford University in the U.S. has developed a self-healing artificial skin that could one day make such problems a thing of the past
One of the major bugbears smartphone users have had, particularly the iPhone, was propensity of the screen on the devices to smash when dropped.
A transparent, healable polymer that can sense pressure could be invaluable for making future generations of devices more resilient to breakages.
In the past decade, there have been major advances in synthetic skin, said Professor Zhenan Bao, the study's principal investigator. But even the most effective self-healing materials had major drawbacks.
Some had to be exposed to high temperatures, making them impractical for day-to-day use. Others could heal at room temperature, but repairing a cut changed their mechanical or chemical structure, so they could only heal themselves once.
Most importantly, no self-healing material was a good bulk conductor of electricity, a crucial property.
'To interface this kind of material with the digital world, ideally you want them to be conductive,' said Benjamin Chee-Keong Tee, first author of the paper published yesterday in the journal Nature Nanotechnology.
Research: Post doctoral scholar Chao Wang cuts through a sample of the self-healing plastic material developed in the Bao lab at Stanford University
The researchers succeeded where others failed by combining two ingredients to get what Professor Bao calls 'the best of both worlds' – the self-healing ability of a plastic polymer and the conductivity of a metal.
They started with a plastic consisting of long chains of molecules joined by hydrogen bonds – the relatively weak attractions between the positively charged region of one atom and the negatively charged region of the next.
'These dynamic bonds allow the material to self-heal,' said Chao Wang, a co-first author of the research.
The molecules easily break apart, but then when they reconnect, the bonds reorganize themselves and restore the structure of the material after it gets damaged, he said.
The result is a bendable material, which even at room temperature feels a bit like saltwater taffy left in the fridge.
To this resilient polymer, the researchers added tiny particles of nickel, which increased its mechanical strength. The nanoscale surfaces of the nickel particles are rough, which proved important in making the material conductive.
Mr Tee compared these surface features to 'mini-machetes,' with each jutting edge concentrating an electrical field and making it easier for current to flow from one particle to the next.
The result was a polymer with uncommon characteristics. 'Most plastics are good insulators, but this is an excellent conductor,' Professor Bao said.
The next step was to see how well the material could restore both its mechanical strength and its electrical conductivity after damage.
The researchers took a thin strip of the material and cut it in half with a scalpel. After gently pressing the pieces together for a few seconds, they found the material gained back 75 per cent of its original strength and electrical conductivity. The material was restored close to 100 per cent in about 30 minutes.
'Even human skin takes days to heal. So I think this is quite cool,' said Mr Tee. What's more, the same sample could be cut repeatedly in the same place. After 50 cuts and repairs, a sample withstood bending and stretching just like the original.
Breakthrough: A small piece of the self-healing material is sliced with a scalpel. The researchers say the material repairs itself in about 30 minutes
The composite nature of the material created a new engineering challenge for the team. Professor Bao and her co-authors found that although nickel was key to making the material strong and conductive, it also got in the way of the healing process, preventing the hydrogen bonds from reconnecting as well as they should.
THE iPHONE APP THAT TURNS YOUR KITCHEN TABLE INTO A KEYBOARD
A prototype app for the iPhone allows users to turn any tabletop into a keyboard.
The Vibrative Virtual Keyboard uses the iPhone 4's built-in accelerometer to read the vibrations as fingers tap a surface to work out which 'key' is being pressed.
By analysing the strength and frequency of tremors through the surface the phone is resting on, the software works out the approximate location of the strike on a virtual QWERTY keyboard.
The app has been developed by Swiss designer Florian Kräutli for his one-year cognitive computing master's degree at Goldsmiths, University of London.
'Touch screen devices, such as smartphones, lack a suitable method for text input which can compete with mechanical keyboards,' Mr Kräutli said.
'The Vibrative Virtual Keyboard aims to appease the frustration felt by smartphone users when faced with drafting lengthy emails or notes on a small onscreen keyboard.
'The keyboard requires no additional hardware as it taps into an iPhone's built-in accelerometer, which is able to measure the vibrations caused by typing on any hard surface.'
For future generations of the material, Professor Bao said her team might adjust the size and shape of the nanoparticles, or even the chemical properties of the polymer, to get around this trade-off.
Nonetheless, Mr Wang said the extent of these self-healing properties was truly surprising: 'Before our work, it was very hard to imagine that this kind of flexible, conductive material could also be self-healing,' he added.
The team also explored how to use the material as a sensor. For the electrons that make up an electrical current, trying to pass through this material is like trying to cross a stream by hopping from stone to stone.
The stones in this analogy are the nickel particles, and the distance separating them determines how much energy an electron will need to free itself from one stone and move to another.
Twisting or putting pressure on the synthetic skin changes the distance between the nickel particles and, therefore, the ease with which electrons can move. These subtle changes in electrical resistance can be translated into information about pressure and tension on the skin.
Mr Tee says that the material is sensitive enough to detect the pressure of a handshake. It might, therefore, be ideal for use in prosthetics, Professor Bao added.
The material is sensitive not only to downward pressure but also to flexion, so a prosthetic limb might someday be able to register the degree of bend in a joint.
Mr Tee pointed out other commercial possibilities. Electrical devices and wires coated in this material could repair themselves and get electricity flowing again without costly and difficult maintenance, particularly in hard-to-reach places, such as inside building walls or vehicles.
Professor Bao said the team's goal is to make the material stretchy and transparent, so that it might be suitable for wrapping and overlaying electronic devices or display screens.
Not only is our skin sensitive, sending the brain precise information about pressure and temperature, but it also heals efficiently to preserve a protective barrier against the world.
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October 23, 2013
Have done a basic photography course so I am using my camera in manual mode, but still have a lot to learn in low light situations.
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Earthly Emporium
€59 for Self-Cleaning Beam Chef Halogen Turbo Oven, incl. Delivery
Delivered within: 14 days
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- We've got a great deal cooking.
- €59 for a Self-Cleaning Multifunctional Halogen Beam Chef Turbo Oven.
- Broils, bakes, barbeques, fries, roasts, grills and steams.
- Delivery included.
Why did the chicken cross the road? I have no idea, all I know is that he was succulent and tasty, perfectly cooked. Make meal times easier and faster with today's hot deal. Pay €59 for a Self-Cleaning Multifunctional Halogen Beam Chef Turbo Oven, including delivery.
Check out the video below to see the Beam Chef in action.
- Ideal for cooking chicken, turkey and much more.
- Broils, bakes, barbeques, fries, roasts, grills and steams.
- Capacity: 3 gallons/13l.
- Power rating: 1300 watt.
- Colour: white.
- Features: rotary control dial, timer knob, temperature knob, side and upright handles.
- Cooks two to three times faster than a standard oven.
- Heat-resistant glass bowl can be removed from stand - easy to clean.
Earthly Emporium
ConditionsLimit: 4 for you and 4 gifts for others
Please provide full address when purchasing. Delivery within ROI only. Subject to availability.
See the rules that apply to all deals Delivery Timeframe: 14 days
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Eterea Post Bong Band - Live
Feedback All Stars
The Eterea Postbong Band are one of the most incredible music machine ever seen on Italian land.
The 4 de-evoluted beings wear work suits and anti gas mask, they dominate their strange and improvised instruments held together with tape and pegs: amplified typing machines, laser guitars, percussion and lo-fi electronic drums. Digital tones and analogical impacts united in a futuristic multicolored body thought for velocity. Winners of the very underground and desired "Electronic drum competition"; Promoters of the situationist "Salsa Bianca Operation", which saw them in surprise performances at night kebab kiosks around the kingdom.
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Offers over £240,000
Howard Road, Cambridge, Cambridgeshire CB5Flat for sale - 2 bedrooms
A two bedroom ground floor maisonette offering lovely views over the meadows. In brief comprising of a lounge/diner, kitchen, two bedrooms and a family bathroom. (contd...) More details
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This Sunday the Erlanger Health Day at the Chattanooga Market offers health and wellness information and a variety of free health screenings.
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Falls Church Tutoring Services
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"Great company - left due to some slightly bad luck "
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at Morningstar full-time (More than 5 years)
I was free for almost the entirety of my time at MStar to propose the best solutions to problems, and then apply those ideals to what could actually be accomplished within business constraints. Great colleagues within our division and across the enterprise. Senior management was always supportive as well. For entry and mid-level staff you won't have problems building a career here - for more senior folks, as always, there has to be a little luck as well, for the right position to be available at the right time. Comp and benefits are more than fair, and the work is as challenging as you make it.
Can't think of any except to ask potential colleagues during the interview process about their direct management chain. 95% are great to deal with. If those folks are happy, and you're willing to work hard, you will likely be, too.
Advice to Management
Listen to your folks. You do a great job of living your values. When a couple of people stray from that, it stands out in sharp relief. I tried to communicate that, and thought I was heard fairly, but, unfortunately, felt there was no way to be happy and stay. My results may be anomalous (almost by definition), but they are mine...
- Any Location
- Any Job Title
- Any Status
Helpful (2)
"Without clear direction or leadership "
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at Morningstar full-timeDoesn't RecommendNeutral OutlookApproves of CEODoesn't RecommendNeutral OutlookApproves of CEO
Until they were cut significantly after moving into their $50million dollar head quarters, the benefits were the best I've seen. Great people
Most of management have only ever worked for Morningstar so their view of the world and how things work there are not always aligned with reality
Helpful (1)
"Fantastic benefits, nice CEO, but mindbogglingly incompetent and advantageous senior Managements. "
- Work/Life Balance
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at MorningstarApproves of CEOApproves of CEO
Great benefits, lovely location, very nice working environment (architecturally).
It's a very comfortable place to work in financially, but not a great place to grow with. I've worked in several divisions of the company and was amazed to see how the senior managements are clueless of what is going on, extremely disorganized, and are never up-to-date with the ongoings in their own group. It is surprising how many of the managers will put their team members to work throughout the night for several days while they go home as the clock strikes 5pm.
The company pays well, provide great benefits, but at the price of your sanity and personal well-being. I experienced very little growth.
Advice to Management
Keep better track of your senior management's practices, and listen a bit more to the cries of your employees because there are plenty of hard working people that are being taking advantaged of.


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