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Volleyball Takes Second at Challenge
MORGANTOWN, W.Va. – With a season-high 13 service aces, the West Virginia University volleyball team defeated Wright State 3-0 (25-14, 25-18, 25-22) in the final match of the West Virginia Golden Horseshoe Challenge, Saturday at the WVU Coliseum.
The Mountaineers (6-5, 0-1 Big 12) took second at the tournament while the Raiders fell to 1-11 on the season and took fourth.
"We progressively improved throughout the tournament," coach Jill Kramer says. "We had a lot of changes in our lineup throughout the weekend and Nikki (Attea) did a great job staying in there for six rotations. Teams went after her and she handled serve receive well and passed really good numbers this weekend.
"Elzbieta (Klein) came in and did a good job. The team got used to the changes in the lineup, worked through them and really started to work together as a team."
WVU began the match with a 6-2 lead off of kills from Attea and freshman outside hitter Hannah Sackett. A strong serving run from Klein, which included two service aces, extended the Mountaineers' lead. Wright State could not find an offensive rhythm as Attea put down her fifth kill to take the first set 25-14.
Two service aces from freshman setter Brittany Sample started WVU off on the right foot in set two. A timeout at 20-11 gave the Raiders momentum, but two kills from Sackett ended the set 25-18 and gave the Mountaineers a 2-0 lead in the match.
The third set was tightly contested until 18-18 when two kills from Sackett and a kill from Klein gave WVU its first solid lead in the set. Errors by the Raiders and two blocks from the Mountaineers finished off the final set and gave WVU the victory.
"We talked about being mentally tough and all that means is coming out and playing our pace," Kramer says. "We have not come in and set the tone for a match this season. We have been playing the type of game that the other team played. In this match, we came in, we set the tone and did a good job of keeping our play at the same level throughout."
Attea, an all-tournament selection, and Klein each posted 10 kills for a .381 and .364 hitting percentage, respectively.
Freshman libero Anna Panagiotakopoulos was also selected for the all-tournament team and finished the challenge with 51 digs and five service aces.
WVU will have a short turnaround as they travel to Robert Morris on Tuesday, Sept. 11 to take on the Colonials at 7 p.m. at Charles L. Sewell Center in Moon Township, Pa.
"Tomorrow, our girls are going to be getting a whole lot of treatment because they played four matches of volleyball this weekend," Kramer says. "Robert Morris did the same thing so we are going to be in similar situations. On Monday, we will get back into the gym and really work on our serve and pass. We had a better serving performance this weekend and that is something that we had really been focused on. We have to stick with those fundamentals and at the same time, we have to make sure we have some fresh legs for the match on Tuesday."
Football: Tony Gibson Preseason
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Coach Dana Holgorsen
2015 Bob Huggins Fantasy Camp
Womens Soccer: Ashley Lawrence Goal vs. NL
Wrestling: Nick Marable World Team Trails Preview


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- Dismissal of Proposition 103 won't affect FasTracks' tax-hike prospects, transit backers say
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- Election results show Coloradans have a sour taste for tax fixes
- Denver voters reject sick-pay mandate by 2-1 margin
- NORTHGLENN: Two new faces likely on City Council.
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- LITTLETON: Beckman, Cole, Valdes ahead in races for council.
- GREENWOOD VILLAGE: Gordon, Bishop take District 4; Roemer heads to re-election
It appeared Marc Williams will be the next mayor of Arvada. At press time, Williams, a council member at large, was leading challengers Dave Chandler and Dan Bidstrup with 62.3 percent of the vote. He succeeds Mayor Bob Frie. In the race for Williams' at-large seat, Bob Fifer led Ed Tomlinson with 53.4 percent of the vote. Incumbent Mark McGoff held a big lead over challenger Cody McNutt in the District 2 race with 54.7 percent of the vote. District 4 Councilman Bob Dyer was unopposed. Joe Vaccarelli, The Denver Post

subset: commoncrawl


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Death Notice March 27, 2013
Date posted: March 27, 2013
Stella Byrtus Withrow
Stella Byrtus Withrow, 94, of Sheridan, Wyoming, died Tuesday, March 26, 2013 at her residence. Arrangements are pending with Champion Ferries Funeral Home.
Ruth G. Atchison
Ruth G. Atchison, 90, of Sheridan, passed away on Wednesday, March 27, 2013 at the Westview Health Care Center.
Online condolences may be written at www.kanefuneral.com.
Kane Funeral Home has been entrusted with arrangements.
Copyright © 2015 The Sheridan Press or Sheridan Newspapers, Inc.
Reader Comments
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13. After the epoxy primer dried, Mike applied sealer.
14. Finally, with help from Brady Brodgin at R & B Body Shop in Pampa, Texas, Mike applied a few coats of factory Sunfire Yellow paint.
15. The underside of the hood, once raw fiberglass, is now smooth and painted flat black, just like the original factory hood.
16. It was then time for Mike to install a pair of left and right hood grilles.
17. Both grilles attached to the new hood on the bottom side, just like on a factory hood.
18. The "Corvette Sting Ray" medallion from the small block hood is the same one used on the big block hood. He simply pressed the emblem into the holes and secured it with nuts on the underside.
19. The stock hood support was reused on the passenger side.
20. Like the hood support Mike also reused the original male hood lock assemblies.
21. The hood fit very well the first time, but was just a little low. Mike's friend, Brady Brogdin, adjusted the hood lock assemblies so the hood set up a little higher.


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IT Training & Certification News | Job-Seeker Tips | IT Insider Perspectives
In a tough job market, it pays to be strategic, and to look for positions in industries with the best opportunities for career growth and upward mobility. ITCareerFinder examined tech job growth rates from the leading unbiased employment sources, including the U.S. Bureau of Labor Statistics, to identify the fastest growing IT careers for 2012 and beyond.
Here are the top five fastest growing IT career paths:
Sources: U.S. Dept. of Labor Bureau of Labor Statistics (bls.gov); O-Net Online (onetonline.org); Healthcare Information and Management Systems Society (himss.org); CNN Money (money.cnn.com)
Read deep dive job descriptions of the most sought-after IT career paths.
Find the author of this blog on Google+ for a first look at similar stories.
Thanks for the post. It helps to know where the jobs are so far as the IT field is concerned. There are two aspects of game and web development – one has to do with programming and the other has to do with design. Those who are interested in the design aspect of web and game development should look to complete a graphic design degree or a related program. A degree in computer science, on the other hand, is an ideal fit for individuals interested in the programming aspect of the two fields.
Thank you for sharing an awesome post! We're experiencing a huge increase in demand for specialized web 2.0 developers, especially those with database skills. For example, .NET and ruby on rails programmers are definitely in high demand, but we're seeing less and less qualified applicants showing up in our resume logs. So much opportunity; developer are really missing the boat here!
Your website is very cool. I'm impressed by the details that you have on this and other blogs. It reveals how nicely you understand and research the subject matter. We bookmarked and will come back for more...


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The Wonders of the World 46 Monuments of Civilization (Paperback)
|Author: Workman Publishing (COR)
Learn more about The Wonders of the World:
Format: Paperback
Publisher: Workman Pub Co
Sku: 204198125
Publish Date: 11/1/2007
Dimensions: (in Inches) 10.5H x 4.25L x 0.75T
Pages: 50
Age Range: 13 to 16
See more in Social Science / General
|The Alhambra. Machu Picchu. The Eiffel Tower, the first structure in history to surpass the height of the Great Pyramid of Khufu. And of course the Taj Mahal, built for love and bankrupting an empire. Through monuments we learn about history, culture, the rise and fall of civilizations-the unlimited reach of the human imagination. From Stonehenge, a primitive space observatory, to the International Space Station (the only manmade wonder not on Earth), Fandex puts 4,500 years of temples, tombs, cathedrals, fortresses, mosques, palaces, and other unmatched architectural creations into your hands.
From the Publisher:
The Alhambra. Jerusalem's Dome of the Rock. The Taj Mahal, which bankrupted an empire in the name of love, and the Eiffel Tower, the first structure to surpass the height of the Great Pyramid of Cheops. Through monuments we learn about history, culture, the rise and fall of civilizations-for example, that to create the giant stone figures of Easter Island, up to 20,000 natives must have lived there before denuding the island's rain forests and disappearing. Or that the bridges and canals of historic Amsterdam actually connect ninety man-made islands, making the city of merchants one giant dock and warehouse.
A subject perfectly attuned to the strengths of Fandex-its family-friendly format, die-cuts and illustrations, and lively educational essay-per-entry-The Wonders of the World is an essential introduction to our most magnificent buildings and monuments. From Egyptian pyramids to the International Space Station (the only man-made wonder not on earth), it covers 4,500 years of world history.
The authorship is impeccable-Anthony M. Tung is "a walking encyclopedia of the history, principles, and practices of urban preservation . . . a genius in [his] field," writes Tom Wolfe. The reach covers the whole world. And the information is fascinating: Did you know that the bronze for the dazzling Renaissance altar canopy of St. Peter's was stripped from the ancient Roman Pantheon? Or that the Himeji Castle in Japan was built to deceive, as a mile-square labyrinth of mazes, false floors, and spiraling alleys?


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So you just got proposed and you are looking for the most beautiful wedding gown now. There are many gowns in Singapore and wherever you turn your head to, they all costs a bomb. However if you are on a tight budget, you think that it is highly impossible to get the best gown you can afford, don't lose heart. This article will show you how to really find those wedding gowns on a tight budget in Singapore!
You just need to dig deeper.
Seasonal Sale
Seasonal sale! Christmas! New Year Sale! Mid Year Sale! National Day! Independence Day! Usually, in most countries, merchants and retail shops will roll out attractive sales in accordance to their holiday periods. Some could be in accordance to their festive season, while some can be due to promotional periods to boost tourism.
Notice the promotional period in your country, or other countries if you are set your eyes on a certain brand of wedding gown. Sometimes, to rent wedding gown in singapore can be cheaper. You really never know when these sales roll out, what kind of discounts and value you can really get.
So get your eyes up and get a good sense of when the sale is going on and you will surely get a good deal.
Wedding Fairs
Many times, there will be fairs that mostly have merchants in the wedding industry for consumers to go to. These fairs consists of many wedding businesses which provides everything you need to have a beautiful wedding experience. Chances are the majority of these fairs are taken up by bridal studios which may or may not provide a one stop wedding gown, photography and videography service.
You will undoubtedly get the most value when you sign up for a bridal package in these fairs. Wedding gown rentings in Singapore often happens among brides and really is not that much of a big hassle. But do note, walk around and see every bridal merchants before settling down for one. Sit down and talk to them, take a few days if needed. Do not be in a hurry to sign and settle on one because you really never know what you will get if you think and consider properly and open your doors.
When you find a gown from those fairs, see if you can negotiate for more value that comes with the package. There will be tons of designs on the gowns and you will be spoilt for choice.


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Tampa won't lift ban on lawn sprinkling
Mitch E. Perry
WMNF Drive-Time News Thursday | Listen to this entire show:
Despite the recent rains and increased pressure from landscapers negatively affected by water restrictions, the Tampa City Council today voted to continue the ban on lawn sprinkling in the city.
Six weeks ago, the Council voted for the measures, the toughest water restrictions in the state. Then wo weeks ago, City Councilwoman Mary Mulhern proposed a motion to revisit the issue. But before the debate even began, Mulhern pre-emptively said she would continue to support the ban.
Councilman John Dingfelder has been the only consistent vote against the measure. After hearing a presentation by city staff that said the recent storms have increased the water in the reservoir and the flows coming in to the river, he challenged his colleagues to join him in reversing the ban.
Councilwoman Gwen Miller disagreed with Dingfelder, saying emergency conditions led the Council to enact the ban.
Councilman Charlie Miranda has been the most articulate voice on the Council in support of the ban. In maintaining the ban despite increasing pressure to back off, he said the city was at a crossroads between what he said was water conservation and "politics as usual."
A motion to over the sprinkling ban failed, with Dingfelder joined by Council members Joseph Catano and Linda Saul-Sena. So did a motion by Council Chair Thomas Scott that the city maintain the current ordinance and allow Mayor Pam Iorio to change the ban when she sees fit.
That motion seemed to offend Dingfelder, who seconded Scottâs motion but then appeared to blast his colleagues for appearing to pass the buck.
The Scott amendment failed, with the majority keeping everything status quo.comments powered by Disqus


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Wireless scanning
Will this machine scan over the wireless network to my iMac?
- Asked by Paul H from Tega Cay
Epson WorkForce WF-2540 All-in-One Printer
Product No Longer Available
1 Answer from the Community
Best Answer:
Mine scans from my Mac but will not scan via the buttons on the printer.
I had hoped finally this printer would be the first to actually work well with the Mac but it does not. The software supplied freezes. The OSX instructions are HORRIBLE and there is not much help on the internet. I finally gave up and uninstalled all the Epson software and just use the built in OSX features to scan from the computer.
- Answered by Ken M from Vancouver


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Hmm.. There are a few.
First Google (Its my homepage)
Then TamaTalk
Then YouTube
Then Telyads (I like to watch adverts. I know its kind of silly but I like to do it anyway.)
Then EBay
Then Club Penguin/Webkinz
Then Pokemon
Then this cool Japanese website witch has a lot of channels to watch
Then it varies.
I also check TamaTalk daily throughout the day.


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The 3/4" washer and the screen washer are used with all our 3/4" FHT fittings and hose ends. Use this type of washers and screen for repairs or replacement when your swivel adapter in your drip system or in your hose are leaking
Categories: Filter Components, Screens & Washers
|Available Models
|40 Mesh Washer w/ Screen for Hose Adapters
|$0.40 ea.
|Hose Washer
|$0.20 ea.
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Tel: 760-597-1669 : Toll Free: 877-597-1669 Fax: 760-597-1673
Business Hours: M-F, 7 AM - 4 PM (PST)
We are not a retail store, we do offer will call during checkout for local customers.


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Stores »
a casual tunic that is super stylish & funky
We are a community of shoppers sharing our best finds from across the web.
© 2015 ThisNext, Inc. ThisNext is a member of BUZZMEDIA Entertainment, a division of BUZZMEDIA.
Create your own free digital magazine at our new site Glossi.com


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Dr. Jennifer Schaumberg
Dr. Jennifer Schaumberg is a board certified Oral and Maxillofacial Surgeon. Dr. Schaumberg was born and raised in
Dr. Schaumberg is board certified, a Diplomate of the American Board of Oral and Maxillofacial Surgery. She is actively involved in the American Association of Oral and Maxillofacial Surgery, Alpha Omega International Dental Fraternity, The American Dental Association, Florida Society of Oral and Maxillofacial Surgeons,
Dr. Schaumberg teaches the Advanced Oral and Maxillofacial Surgery course at Broward County Dental Research Clinic. She lectures extensively in the areas of LASERS, CAT scans, dentoalveolar surgery, implants, bone grafting, cosmetic surgery, pathology and reconstruction. Dr. Schaumberg is also the president of the Women�s Dental Study Group. She is delighted to bring her love of Oral and Maxillofacial Surgery and her love of teaching together to the community. She believes that a reassuring touch, a kind word and a caring atmosphere is essential for ideal patient care. Dr. Schaumberg�s gentle manner is especially comforting to anxious patients and children.
South Florida Oral and Facial Cosmetic Surgery, Dental Implant Center
701 E Commercial Blvd., Fort Lauderdale, FL 33334
Serving Broward County, Greater Fort Lauderdale:
Home | Patient Information | Meet Us | Oral Surgery | Fort Lauderdale Facial Cosmetic Surgery | Aesthetic Spa & Treatments
Oral Surgery Website Design by PBHS 2005©


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ReBuild Houston is the City of Houston's initiative to improve the quality of life and mobility for residents of the city by rebuilding our drainage and street infrastructure. To support the initiative, the city has established a dedicated, pay-as-you-go fund to maintain the infrastructure, and to plan upgrades to meet future needs as the city grows.
Greenbriar Project - Presentation
Greenbriar Project - Information Handout


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Theoretical Modelling of Aeroheating on Sharpened Noses Under Rarefied Gas Effects and Nonequilibrium Real Gas EffectsSpringer 2014; US$ 129.00
Theoretical Modelling of Aeroheating on Sharpened Noses under Rarefied Gas Effects and Nonequilibrium Real Gas Effects employs a theoretical modeling method to study hypersonic flows and aeroheating on sharpened noses under rarefied gas effects and nonequilibrium real gas effects that are beyond the scope of traditional fluid mechanics. It reveals... more...
Advances in Fluid MechanicsWIT Press 2014; US$ 406.00
Containing the proceedings of the tenth International Conference on Advances in Fluid Mechanics, it follows the success of all previous conferences in the series, the first of which took place in 1996.Topics covered include: Computational methods; Hydrodynamics; Fluid structure interaction; Multiphase flow; Environmental fluid mechanics; Fluidics. more...
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Computational and Experimental Fluid Mechanics with Applications to Physics, Engineering and the EnvironmentSpringer 2014; US$ 179.00
The book presents a collection of selected papers from the I Workshop of the Venezuelan Society of Fluid Mechanics held on Margarita Island, Venezuela from November 4 to 9, 2012. Written by experts in their respective fields, the contributions are organized into five parts: - Part I Invited Lectures, consisting of full-length technical papers on both... more...
Experimental and Computational Fluid MechanicsSpringer 2013; US$ 229.00
This book collects invited lectures and selected contributions presented at the Enzo Levi and XVIII Annual Meeting of the Fluid Dynamic Division of the Mexican Physical Society in 2012. It is intended for fourth-year undergraduate and graduate students, and for scientists in the fields of physics, engineering and chemistry with an interest in Fluid... more...
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Zugeschnitten auf die Studieng�nge Maschinenbau und Verfahrenstechnik an Fachhochschulen, f�hrt das Lehrbuch in das Fachgebiet Fluidmechanik ein. Behandelt werden auch numerische L�sungsmethoden. Der Band enth�lt Beispiele, die durchgerechnet sind. more...
Large-Eddy Simulation in HydraulicsCRC Press 2013; US$ 104.95
Preface 1 Introduction 1.1 The role and importance of turbulence in hydraulics 1.2 Characteristics of turbulence 1.3 Calculation approaches for turbulent flows 1.4 Scope and outline of the book 2 Basic methodology of LES 2.1 Navier-Stokes equations and Reynolds Averaging (RANS) 2.2 The idea of LES 2.3 Spatial filtering/averaging... more...
Fluid MechanicsElsevier Science 2013; US$ 72.95
Written in a clear and simple style, this textbook on fluid mechanics gives equal emphasis to both geophysical and engineering fluid mechanics. For physicists, it contains chapters on geophysical fluid mechanics and gravity waves; for engineers, it has chapters on aerodynamics and compressible flow. Of common interest are chapters on governing equations,... more...
New Results in Numerical and Experimental Fluid Mechanics VIIISpringer 2013; US$ 299.00
This volume contains the contributions to the 17th Symposium of STAB (German Aerospace Aerodynamics Association). STAB includes German scientists and engineers from universities, research establishments and industry doing research and project work in numerical and experimental fluid mechanics and aerodynamics, mainly for aerospace but also for other... more...
Momentum Transfer in FluidsElsevier Science 2012; US$ 72.95
Momentum Transfer in Fluids provides information pertinent to fluid mechanics. This book discusses several topics related to the movement of fluids, including boundary-layer analysis, statistical treatment of turbulence, as well as laminar and turbulent shear-flow. Comprised of seven chapters, this book starts with an overview of the physical nature... more...


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Quite a treat this week, as we get the lowdown on the unique life of a London pigeon. The infamous Brian of Pigeon Blog fills us in on everything from why London rocks, what's up with the squirrels and what happens when the pigeons party in Piccadilly Circus.
Brian (left) and Johnny One Leg hanging out by the fountain in Trafalgar Square.
If you had to describe your blog in less than 15 words how would you do it?
Pigeon Blog is the online diary of a London pigeon. Simple as.
How and why did you start blogging?
I started the whole thing as a bit of a laugh really. Just the day-to-day doings of a London pigeon. Never thought it would catch on. To be honest, I wasn't sure anyone was going to be that interested in a pigeon's point of view. Just goes to show. Jesus. Last year I even got into the Time Out Top 50 London websites, and all I do is go on about stuff we pigeons get up to. Amazing, really. As for how, that's a whole other story. I first got to grips with the Internet a few years back, which is no mean feat for a pigeon let me tell you. Tricky stuff. I'm loads faster now than I was though, which is good. Getting a single post done used to take me several hours of seriously strenuous beak to toe maneuvers. Now I can bang one out in ten minutes if I want to.
What about London inspires your blog?
Everything. London rocks as Cities go. Much better than Milton Keynes. Is that a city? I love the parks, the bits of them without the squirrels that is. Then there's the architecture, even better from the air. I think what I love most though is the variety of ledges. Beats everywhere I've ever been for ledges. Short, long, high, low, sheltered, not sheltered. The works. Something for every pigeon. I did a feature on Pigeon Blog about it. A series of posts called London's best ledges, originally intended as a bit of a guide for the visiting pigeon. Empty though it is, Trafalgar Square is still a main hang out for the London pigeon. Nothing like it was back in the day, which is a shame. Saying that, not too keen on the place at weekends. Way too many out of towners for my liking. Generally, apart from the banning of free seed handouts and the occasional hawk, I'd say we pigeons got it pretty good here.
What would be your dream day/event in London to post about?
My dream event, and I think I speak for all London pigeons when I say this, would be our very own National Pigeon day. They did it in New York last year. Unfortunately, it was largely attended by freaks, which meant the NY pigeons were forced to give it a wide berth. Wouldn't be like that here. I'm thinking some kind of outdoor event, maybe in Trafalgar Square for old time's sake? I'm thinking free seed, maybe some foam? I'm thinking a kick arse party. A musical extravaganza. Shift focus from the do-gooder war hero pigeons like Cher Ami, not that Cher doesn't deserve a shout out; dedicate it to the urbans instead. The real heroes. We deserve it. Just for one day, let us bring a little of that pigeon magic back to the Square. Will Young could host it. Sure he'd be up for it. Maybe have The Pigeon Detectives do a set, or The Kooks?
What's the deal with you and the squirrels?
There's been a deal between pigeons and squirrels for longer than I know, and that's quite a while. There used to be an agreement in place – squirrels stick to parks, pigeons get the streets, but then it all changed. Squirrels got bored of the grass, and started moving in on the concrete. Seriously taking over, throwing their weight around the rooftops. Well out of order. Recently though, it got a whole lot worse. Ever since they started learning the Kung Fu moves, they've been a freakin' nightmare giving it large all over London. We're coming back at 'em though, throwing together a few nifty moves, like flying away. Works every time. Came up with something else recently too. Words. Generally, squirrels are poorly educated and don't really do words, so I reckon we can beat them with the lingo any day. Crush them with wit. Mash 'em up with our verbal dexterity. So far, so good. 'Operation Stop The Squirrel', granted not the most imaginative of names, is most definitely underway. What do you wish for the pigeons of London? What would you change for them? Free seed on every corner and the positive encouragement of pigeon feeding, obviously. Maybe even offer some sort of incentive? How about a cash discount on bread if you share it with a pigeon? Oh, and some mini versions of those outdoor heater things on rooftops. That would work. Maybe a few smaller ones for the ledges? The removal of bins on certain streets like Brick Lane. Anywhere with a high concentration of throwaway food joints. I'd also remove all squirrels. Stick the whole lot on an island somewhere off the West coast of Scotland. The other thing I'd do is get rid of the anti-pigeon spikes. Totally sucks if you accidentally park the arse on one of those, and I speak from experience. Jesus. Didn't fly right for weeks.
What's your favourite post you've ever written?
Blimey. No idea. That's a tough one. I guess some of my favorites are where people send me stuff. Had a great one the other day – some dude had his Pigeon Blog bag searched at the gate of a cricket match he went to in India. Kid you not. Then, and this is the best bit, the whole affair only goes and gets on Sky Sports News. Hilarious. He sent me a pic and everything. Some togged up official rummaging around in a bright yellow Pigeon Blog bag. Classic. Some of my recent coverage of 'Operation Stop The Squirrel' seems to have caused a bit of a stir in the nation's loins too, which is always good.
Would you feel more or less connected to London, would you have missed out on things without your blog?
Absolutely. Seeing as getting to the heart of a London pigeon's world is what Pigeon Blog is all about, Pigeons everywhere want me to get involved in what they're up to just so I can write about it. Frankly, if it wasn't for the invites, I'd probably have given up ages ago. Kidding. But it's not just the hard partying, having the blog also means I get to do stuff for the London pigeon community, real stuff like my Give Pigeons A Chance campaign a couple of years back. Ended up with over 400 signatures on an online petition. Shed loads better than I could have got with a clipboard any day. Small and brief though it was, I like to think I made a difference. I'm up for doing more of it too. Getting going on a National Pigeon day would be a good start. Up the profile of the pigeon Change people's perception. The rats with wings thing is such a misnomer. Pisses us right off.
What do pigeons get to see, or know about London that others don't?
For a start, we get to see it from the air on a regular basis, which is great on a clear day, but not so good when it's foggy. Getting sky bound means that we never have to worry about the cock up that is Transport for London either. Take the other day when it snowed. Apart from risking the loss of toes to gangrene, none of it really bothered us pigeons. Sub zero temperatures aside, getting around was piece of piss. The rest of London though. Jesus. Totally fell apart. Massive chaos. For the first time in a while I actually saw the look of envy in some bloke's eyes as I flew over just as he landed on his arse. There's also the obvious stuff like where the best ledges are and, really important at this time of year, which rooftops have the poorest insulation.
Tell us about another London blogger you like.
My fave blogger in London has got to be the mighty Annie Mole of Going Underground. She rocks, especially when it comes to giving advice on which tube stations are pigeon friendly, sadly not many these days. Another one I like, but mainly coz it's a useful source of information on derelict buildings in London, is Derelict London. Then there's Unreliable Witness. Andre Jordan cracks me up.
And for some general London chat… Where do you live and why do you love it?
I live in Soho, on Beak Street, right above Bistro 1. Apart from being well central, it's also close to Piccadilly Circus, which is one of my favourite spots in London. Soho Square's a great place to hang too, especially in the summer. Bread bits everywhere. Heaven for the pigeon.
What's your favourite place in London?
I'd have to say Piccadilly Circus. There's this game we pigeons play called The Eye Game. You fly right up to the video wall, stare at it, close as you can, look deep into the red. Totally spins the head out. It's the quickest way to get off your nut there is, and I'm a sucker for it. I reckon every pigeon in London has had a go at it at least once.
Have you ever been sick on the tube?
Sadly, yes. It was after a go at The Eye Game one Saturday afternoon. I had to visit some pals in Chiswick after, flew as far as Hammersmith, decided I was too fucked to fly any more, so I got the tube. Big mistake. Threw up at Ravenscourt Park. Not good, and well embarrassing. Mart was with me at the time. He pissed himself laughing. I didn't. Gave the tube a miss for quite a while after that!


text:
November 5, 2012
Source: Journal of Clinical Investigation.
Introduction: The process of scientific discovery includes healthy, rigorous discussion amongst scientists and other stakeholders before a path is found towards new preventions and treatments of disease. The animal research reported in this news update is one part of this discussion, and more studies on how these findings could impact patients are needed. Current treatment options for wet age-related macular degeneration (AMD) include eye injections with drugs that help to slow vision loss by reducing the availability of excess VEGF protein (thus, cutting off the growth of leaky, damaging blood vessels). These treatments have been approved by the Food and Drug Administration (FDA), and, even after the drug is now available on the market, the FDA constantly monitors for potential reports of serious side effects. BrightFocus Foundation has a history of funding cutting-edge research that adds to the discussion and discovery of new preventions and treatments for AMD. For more information on BrightFocus-funded AMD research, visit our research grants web page. Please note that the senior author of the article, Martin Friedlander, M.D., Ph.D., serves as a scientific advisor to BrightFocus.
Dr. Martin Friedlander Courtesy of the Scripps Institute
Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity may do more harm than good. In the new study, the researchers deleted the gene for the blood-vessel growth factor VEGF, which has been implicated in stimulating abnormal blood vessel growth in a range of cancers and eye diseases, from cells in the retinas of adult mice. The results showed that without VEGF a large subset of light-sensing cells lost their main blood supply and shut down, causing severe vision loss. "It's becoming clear that VEGF has a critical function in maintaining the health of the retina, and we need to preserve that critical function when we treat VEGF-related conditions," said TSRI Professor Martin Friedlander, MD, PhD, senior author of the new study, which appears in the November 2012 issue of the Journal of Clinical Investigation. Major Target for Drug Developers VEGF (vascular endothelial growth factor) has long been a major target for drug developers. Tumors often overproduce VEGF to stimulate local blood vessel growth and thus keep their fast-dividing cells well supplied with oxygen and nutrients. Low-oxygen conditions in the eyes of elderly or diabetic individuals also can trigger the overproduction of VEGF, resulting in a vision-destroying bloom of abnormal, leaky retinal blood vessels. Several anti-VEGF drugs (such as Lucentis® (ranibizumab), Macugen (pegaptanib), Eylea® (aflibercept) and Avastin® (bevacizumab)) are already in use, and dozens more are in clinical trials against cancers and common eye disorders such as wet macular degeneration.
However, to date there have not been extensive studies on the effects of such drugs on the normal role of VEGF, in part because it is hard to generate adult animals that lack the VEGF gene. When the gene is removed from the embryos of mice, in a standard "knockout" experiment, the mice fail to develop normally and die before birth. New Insights In the new study, Friedlander laboratory postdoctoral fellows Toshihide Kurihara, MD, PhD, and Peter D. Westenskow, PhD, found a way to delete the major VEGF gene from mice after the animals had grown to adulthood. To determine VEGF's role in the retina, they confined the gene deletion to the animals' retinal pigment epithelial cells, which nourish and repair the retina and are a major retinal source of VEGF. The result suggests that VEGF does have a crucial function in the adult retina. "Only three days after we knocked down the gene, we observed the complete deterioration of the choriocapillaris, a layer of capillaries that is a major supplier of nutrients to the outer retina, the location of the rod and cone photoreceptors," said Kurihara. Nearby light-sensing cone cells, which are specialized for detecting color and fine detail in visual images, also rapidly lost their function, causing pronounced vision loss in the mice. Seven months after the knockdown of the VEGF gene, the retinal damage and vision loss were still evident. "The deterioration seems irreversible if VEGF is not present," said Westenskow. Rod cells, which support low-light and peripheral vision, were not affected by the VEGF-gene deletion. The researchers note that cone cells may be more vulnerable because they are unusually active metabolically and may be unable to withstand a significant decrease in blood supply. Cone cells also bear receptors for VEGF molecules and thus may require direct VEGF stimulation to remain healthy. In any case, even if only cone cells died and rod cells were spared, a patient would experience severe vision loss. "You'd be defeating your purpose if you dried up the abnormal blood vessel growth but at the same time killed off the cone cells," said Friedlander. Paths for Future Research Whether such side effects are happening with existing anti-VEGF treatments is unclear. While these assessments are possible, but they have been considered prohibitively expensive and invasive. Friedlander, however, now believes such studies are necessary and plans to conduct such assessments in eye-disorder patients—who typically receive direct injections of anti-VEGF drugs to their eyes—to determine whether the drugs are causing these adverse side effects. He notes that the evaluations may be particularly necessary for a new class of anti-VEGF drugs recently approved for use in the treatment of age-related macular degeneration—drugs that are much more potent and persistent than previous anti-VEGF agents. Fortunately, anti-VEGF drugs are not the only possible strategy for treating pathological blood vessel growth, as the new study makes clear. VEGF-related tumors and eye conditions also involve the overproduction of low-oxygen signaling proteins known as HIFs. The team found that deleting the genes for these HIFs in retinal cells largely prevents blood vessel overgrowth in a standard mouse model—without affecting the normal-level production of retinal VEGF or causing eye damage. "In light of the present findings, other strategies for treating these eye conditions could be a possibility," Friedlander said. "Conceivably, an anti-HIF treatment could also be combined with an anti-VEGF treatment, allowing the dose of the latter to be lowered significantly." Adapted from the Scripps Institute
View all news updates for macular degeneration
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