text:
- Report: #402457
Report - Rebuttal - Arbitrate
Complaint Review: Royal Administration Services
Royal Administration Services51 Mill Street, Building F Hanover, Massachusetts U.S.A.
Royal Administration Services Stole my money Hanover Massachusetts
*Consumer Comment: Deceptive practices, missleading policies and lots of fine Print. Buyer Be Aware
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So the status is that I ignorantly signed up with a weak warranty. I struggled to cancel it immediately and in the end they only refunded half. This means for absolutely no service and before service officially started I paid this company about a grand.
It's a strange business. I will include all the names below. When trying to cancel I called them and asked if they were in the office and they said yes. I drove down there and nobody was there. I called and they said they were there but said they could not open the door. I looked in the back window and just saw bags full of shredded documents.
It seems as though this company might not exist at all. Luckily I live close and I don't think they expected me to go there but I understand people from all over the country have problems with them and would never have the chance to go the physical location.
I now understand why they go under so many different names. Which is the following starting with mine:
People's Vehicle Protection, Service Shield, Integrity Automotive Protection, Buyer's Choice, Capital Care, and GEM Care Extended .......
Google the website and the word profits and you will see in bold print "Royal service contracts contribute to the highest dealer profit margins in the industry". What that means is they know they do no service and loophole out of any services. This is a statement made for dealers because in the end they pay the dealer a major (the highest in the industry) portion of the profits they scam from people. Everybody says these things are scams and everybody is correct. I wish I knew this before hand and I really hope somebody gets this information before they sign up.
They are stealing money from people. What really blows my mind is if they are going to steal my money then they should steal it all and not half. There is no rebuttal until I receive the other half. They would like to shift the blame but they already stated "they" sent 100% back to the bank. My service never even began and they took half my money.
PeoplesPower, Massachusetts
This report was posted on Ripoff Report on 12/17/2008 03:09 PM and is a permanent record located here: http://www.ripoffreport.com/r/Royal-Administration-Services/Hanover-Massachusetts-02339/Royal-Administration-Services-Stole-my-money-Hanover-Massachusetts-402457. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 Consumer Comment
Deceptive practices, missleading policies and lots of fine Print. Buyer Be Aware
AUTHOR: Crisp Sound - (U.S.A.)
SUBMITTED: Tuesday, July 14, 2009POSTED: Tuesday, July 14, 2009
I visited the shop about three times between 2007 and 2008; I had to arrange for alternative transportation every time I needed repair work done. This warranty company takes 24 to 48 to inform the dealer of part / work they will cover.
During my last trip in winter of 2009, the service department agent told me directly and I quote: "we deal with all kind of warranty companies out there, yours is the WORST one, They are very hard to deal with"
I finally had enough, the repairs started to cost me money, because the Royal [There is nothing royal about them] refuse to pay for most of the work and I was always digging for my wallet to pay for work done and alternative transportation.
But wait, it gets better! I had a 4 year term or 100K miles, I got sick of the whole thing that I bought a new sedan and wanted to cancel the warranty to get the unused portion or 2 years premium refunded as I was promised by the car dealer during my purchase. Not so Fast!
I called Royal Admin and they asked me to put it in writing, which I did that same day just to get a letter in the mail telling me that I was out of luck!
When I inquired they told me that their secret calculator showed that they do not owe me anything because they paid for claims on my account and that the balance paid exceeds certain magical benchmarks and referred me to their policy.
Well, that was not nice and was not fair! I paid for 4 years, I used 2 year and any five year old will agree that they owe me the difference. I filed a complaint with the A/G and the BBB and got their response in form of copy of policy that was 5 pages long that I never saw! The dealer had me sign the last page when I was picking up my car in a hurry thinking that it was a policy confirmation. I was not giving the run down but I remembered clearly that when I asked about termination, the dealer was adamant that it was eligible for retro credit: "you only pay for the portion used" That was the answer I received.
This is deceptive, unethical, highway robbery! Buyer be aware!
Are you an owner, employee or ex-employee with either negative or positive information about the company or individual, or can you provide "insider information" on this company?
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Poblano Pineapple Picante
- 1 Poblano chile
- 2 sprigs fresh cilantro
- 2 ounces tequila blanco
- 2 ounces pineapple juice
- 3/4 ounce fresh lime juice
- 3/4 ounce agave nectar
DirectionsWatch how to make this recipe.
Cut about an inch off the top and bottom of the Poblano and remove the seeds, leaving body intact. Place the chiles in the freezer for at least 1 hour and up to 24 hours.
In a mixing glass, muddle the cilantro, add the rest of the ingredients, add ice and shake 12 to 14 times. Place the frozen poblano in a pint glass and pour the drink over it. (Alternatively, this cocktail can be served in a martini glass.)
Recipe courtesy of Guy Fieri

subset: commoncrawl


text:
Hello,just wanted to introduce myself...Sheila Boudreaux, member of the Jan 2011 birth board forever.... I was born n raised in Slidell,living in Carriere,Ms. now. Mom of 3 daughters...from a previous marrige,Katie is 20,and Candice is 13. And with my fiancee,Chloe is 15 months. Just found this group and thought it be cool...nice to meet yall!
New member...hi:)
Posted 04/04/2012
Comments (0)
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text:
21 years of experience
Cambridge Hospital
1493 Cambridge St
Cambridge, MA 02139 Phone number & directions
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. James Pollard:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Write a Review
Prepare before visiting Dr. Pollard
Metastatic Melanoma Patient Education Learn all about metastatic melanoma symptoms and treatments by reading Vitals patient education guide.Before Visiting Dr. Pollard Learn More
|More Patient Guides & Topics
Skin Cancer
Breast Cancer
Hodgkins Lymphoma
Pulmonary Embolism
Specialties & Research
Dr. James Pollard, MD is board certified in Diagnostic Radiology.
Education & Awards
Dr. Pollard graduated from Boston University .
Dr. Pollard has 3 hospital affiliations:
- Cambridge Health Alliance : Whidden
- Cambridge Health Alliance: Cambridge
- Youville Hospital and Rehabilitation Center
Similar doctors nearby
Dr. Stephan Auerbach
Dr. Anatoli Shabashov
Dr. Carol Hulka
Dr. Franklin Zweiman
Dr. Joseph Sequeira
Dr. Gregory Harrington
- Additional Information
- Dr. James Joseph Pollard MD is a male Diagnostic Radiologist, has 21 years of experience and practices in Diagnostic Radiology and Vascular & Interventional Radiology.
- Where does Dr. James J. Pollard practice?
- Dr. James Pollard has 1 office location.
Dr. James Pollard practices Diagnostic Radiology and Vascular & Interventional Radiology near Cambridge, MA.
See Cambridge Radiologists.


text:
- Report: #268547
Report - Rebuttal - Arbitrate
Complaint Review: Financing Alternatives
Financing Alternatives565 Cedar Rd. Chesapeake, Virginia U.S.A.
Financing Alternatives, Liberty Financial same co. same rip off Chesapeake Virginia
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http://libertypurchaseprogram.com they would answer after a couple of rings I hope there is someone out there to stop this co. from ripping off others.
tooele, Utah
This report was posted on Ripoff Report on 08/18/2007 08:04 PM and is a permanent record located here: http://www.ripoffreport.com/r/Financing-Alternatives/Chesapeake-Virginia-23322/Financing-Alternatives-Liberty-Financial-same-co-same-rip-off-Chesapeake-Virginia-268547. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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text:
- Report: #1046252
Report - Rebuttal - Arbitrate
Complaint Review: Shanghai Bangze Kitchen Ware Co. Ltd
Shanghai Bangze Kitchen Ware Co. Ltd509 DongZhen Rd. Internet United States of America
Shanghai Bangze Kitchen Ware Co. Ltd About my order Chengxiang district, Putian, China Internet
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But they sent me fake Burberry wrong color wrong size scarves and broken box.
I sent back them today. I sent tracking number to them alredy. And it cost was a $51.35.(Because they said "use only USPS Express Intarnational service.")
Them return policy :If you receive a product from our site is faulty on delivery, you can contact with us to return it and claim for a refund. If a product is found to be faulty (incorrect size, color ect.), you may claim for a FULL REFUND, or require exchange without any extra cost.
They should full refund.
This report was posted on Ripoff Report on 04/25/2013 04:09 PM and is a permanent record located here: http://www.ripoffreport.com/r/Shanghai-Bangze-Kitchen-Ware-Co-Ltd/internet/Shanghai-Bangze-Kitchen-Ware-Co-Ltd-About-my-order-Chengxiang-district-Putian-China-In-1046252. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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- Only search one name at a time if Company has many AKA's.
Advertisers above have met our
strict standards for business conduct.


text:
Please help!
I've just automatically upgraded from the previous version of WP to 3.0
Now my blog home page loads stating:
"Too many redirects occurred trying to open "http://www.idea-sandbox.com/blog/". This might occur if you open a page that is redirected to open another page which then is redirected to open the original page."
I tried turning off all my PlugIns - that didn't work. My main page and other pages work - just not the blog.
I tried turning off my .htaccess file. That didn't help. I don't have special redirects there that I know that could cause the problem.
Help!!! - Paul
Thank You!


text:
Dietetic Internship
Dietetic Internship Program Overview
Thank you for your interest in the Solmaz Institute Dietetic Internship. All interns who successfully complete our program are eligible to sit for the Registered Dietitian (RD) certification exam administered by the Commission on Dietetic Registration (CDR). The Solmaz Institute provides a unique post-baccalaureate dietetic internship that focuses on the prevention and treatment of childhood obesity in addition to meeting the basic competencies set forth by ACEND. At this time there are no other programs with this concentration. Our program is accredited by the Accreditation Council for Education in Nutrition and Dietetics (ACEND).
Interested in applying? Selected candidates will meet the following minimum criteria:
- Interest in becoming a Registered Dietitian. Go to the website of the Academy of Nutrition and Dietetics (AND) at http://www.eatright.org/resource/food/resources/learn-more-about-rdns/what-an-rdn-can-do-for-you to read more about this profession. Learn where RDs practice and what they do!
- Completion of a bachelor's degree, with coursework from an ACEND accredited program (coursework would include nutrition, medical nutrition therapy, chemistries and related labs, statistics, etc). Those who have successfully completed the required undergraduate coursework will have a Didactic Program in Dietetics (DPD) Verification Statement. If you are interested in practicing in the field of nutrition and dietetics please go to http://www.eatrightacend.org/ACEND to learn more about programs in your area that offer this coursework. The Dietetic Internship is a post-baccalaureate program only, the required undergraduate courses are not offered at LRU at this time.
- Further application requirements and instructions can be found under the Admissions tab on the left sidebar of this page.
The Dietetic Internship program offers two location options: Carolinas (North or South Carolina) and a distance option where supervised practice rotations are completed in the intern's own geographic area. For more information, please select location options on the sidebar.
The Dietetic Internship program currently consists of the following components:
- An onsite orientation held on the Hickory campus, during which interns will be familiarized with program details and receive preparation for the supervised practice rotations.
- Four supervised practice rotations: clinical (14 weeks/560 hours), community (10 weeks/400 hours), administrative (6 weeks/240 hours) and enrichment (2 weeks/80 hours).
- Certificate of Training in Childhood and Adolescent Weight Management course offered by the Commission on Dietetic Registration (CDR). Note: students are responsible for all costs associated with this program, including travel, registration, food and lodging. Our students do receive discounted registration for the course.
- An onsite capstone course held on the Asheville campus, designed to synthesize knowledge and skills acquired throughout the year and provide preparation for moving forward professionally
Beginning with the 2016-2017 internship year, the Dietetic Internship program will have the following structure:
- An onsite orientation as described above
- Three supervised practice rotations: clinical (12 weeks/480 hours), community (12 weeks/480 hours) and administrative (6 weeks/240 hours)
- Childhood and Adolescent Weight Managment Self-Study Module offered by the Commission on Dietetic Registration (CDR)
- An online capstone course, with content as described above.
Timeline and Graduation Requirements
The Dietetic Internship is a full-time (40 hours/week) 10 month program and runs from mid-August through mid-May annually. Beginning with the 2016-2017 internship year, the Dietetic Internship will be 9 months and will run from mid-August through April annually.
To graduate, the intern must complete the required didactic work, supervised practice hours, graduate coursework, Certificate of Training in Childhood and Adolescent Weight Management course (beginning 2016-2017: Childhood and Adolescent Weight Management Self-Study Module) and demonstrate satisfactory performance and competence throughout the program rotations, as evaluated by site preceptors and the Dietetic Internship Director. The intern must complete all program and self-assessments. The intern must demonstrate no misconduct, academic or non-academic, and must perform ethically in accordance with the values of the Academy of Nutrition and Dietetics. The intern will receive a Dietetic Internship Verification Statement following successful completion of the dietetic internship. Their name will also be submitted to CDR for eligibility for the RD exam.
Instructions for Application
Please select the Admissions tab on the left sidebar of this page for application instructions.
Solmaz Institute
Everything you need to apply for admission is right here.


text:
How Far Does Your Food Travel?
posted originally from: TheKitchn
For example, it turns out that my craving for celery can be satisfied with Pennsylvania grown stalks, so when I made a salad last weekend with celery in it, I hunted down some PA-grown stuff at the farmers' market instead of just settling for something with a passport from Whole Foods.
They also have a list of "Frequent Fliers," the foods that are commonly air-lifted from their country of origin, racking up global warming emissions. Peruvian Asparagus, Tomatoes from the Netherlands and Chilean fruit like blackberries, cherries and peaches are all on the list. If they're not in season, best to choose something else and the online search tool is a great way to find alternatives.
• Visit the NRDC's Eat Local tool
(Plane image by Flickr member Ack Ook licensed for use under Creative Commons.)


text:
- Report: #326591
Report - Rebuttal - Arbitrate
Complaint Review: JUNIPER BANK AKA BARCLAYS BANK
JUNIPER BANK AKA BARCLAYS BANKWilmington, DE Wilmington, Delaware U.S.A.
JUNIPER BANK AKA BARCLAYS BANK 3 YEARS LATER AND 2 DISCUSSIONS WITH EXECUTIVE HQ, STILL BEING CONNED Wilmington Delaware
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Corporate Advocacy Program™
I bought an Apple G4 ibook in October 2005. I used the Juniper card. The bill was $1100.
Just like all the other people who have written reports, I kept finding that I owed more, not less than I started with EVEN THOUGH I PAID THE REQUIRED AMOUNT EVERY MONTH.
This fraudulent company:
* charges more interest than initially advertised
* charges exhorbitant late fees 1 DAY AFTER THE DUE DATE which then put the customer over the limit
* then charges an over the limit fee
3 years later I still owe them the same amount of money - even though after a conversation with an Executive HQ Team Member last Feb (2007) my balance was down to 700. She assured me my payment would now only be $19 per month.
Even though I pay them every month I continually get calls because they say I owe them more than I am paying It is POINTLESS trying to talk to one of the telephone people.
Now I am getting calls at 6am!!!! I believe that is against the law.
Kilauea, Hawaii
This report was posted on Ripoff Report on 04/16/2008 03:55 PM and is a permanent record located here: http://www.ripoffreport.com/r/JUNIPER-BANK-AKA-BARCLAYS-BANK/Wilmington-Delaware/JUNIPER-BANK-AKA-BARCLAYS-BANK-3-YEARS-LATER-AND-2-DISCUSSIONS-WITH-EXECUTIVE-HQ-STILL-BE-326591. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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text:
Book your room at Pierre & Vacances Residence L'Alpaga - Serre-Chevalier
Get an overview of this hotelSlopeside residence with downhill skiing
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located in the mountains, this ski-in/ski-out residence in La Salle-les-Alpes is within a 10-minute walk of Buissonniere Ski School and Aravet Gondola and close to winter sports such as cross-country skiing and skiing lessons. Etoile Ski Lift and Prorel Gondola are also within 6 mi (10 km).
Property Features
With direct access to the slopes, Pierre & Vacances Residence L'Alpaga - Serre-Chevalier makes guests feel at home with amenities like a steam room, ski storage, and complimentary wireless Internet access.
Room Amenities
All 80 rooms have free WiFi and feature kitchens with refrigerators, microwaves, and dishwashers. Other amenities available to guests include furnished balconies or patios, dining areas, and TVs. Housekeeping is available once per stay.Would you like to give us feedback? Share it! Opens in a new window
Pierre & Vacances Residence L'Alpaga - Serre-ChevalierRoute de Prelong Serre Chevalier La Salle-les-Alpes Hautes Alpes 05240
Hotel Amenities
Hotel Amenities
Pierre & Vacances Residence L'Alpaga - Serre-Chevalier features ski-in/ski-out access and a sauna. High-speed wireless Internet access is complimentary. This ski residence also offers multilingual staff, ski storage, and a safe deposit box at the front desk. Parking is available onsite for a surcharge. Guests can use the outdoor pool at a partner hotel.
- Ski-in/ski-out access
- Ski storage
- 24-hour front desk
- Multilingual staff
- Total number of rooms - 80
- Free WiFi
- Safe-deposit box at front desk
- Free parking nearby
- Self parking (surcharge)
- Sauna
- Number of buildings/towers - 2
- Steam room
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Kitchen
- Separate dining area
- Refrigerator
- Microwave
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Self parking (surcharge), Free parking nearby
Room Amenities
- Housekeeping - once per stay
- Furnished balcony or patio
- Cribs/infant beds (surcharge)
- Hair dryer (on request)
- Separate dining area
- Iron/ironing board (on request)
- Blackout drapes/curtains
- Phone
- Kitchen
- Microwave
- Cookware, dishware, and utensils
- Refrigerator
- Private bathroom
- Bathtub only
- In-room safe
- Television
- Dishwasher
- Free WiFi
Nearby Things to Do
Recreational amenities at the residence include ski-in/ski-out access and a sauna.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Mountain biking nearby
- Sledding nearby
- Downhill skiing nearby
- Cross-country skiing nearby
- Snowboarding nearby
- Snowmobiling nearby
- Snowshoeing nearby
- Hiking/biking trails nearby
- Ski lessons available nearby
- Ski equipment rental shops nearby
- Downhill skiing on site
Hotel Policies
Check-in time ends at 8 PM
Check-in time starts at 5 PM
Minimum check-in age is 18
Special check-in instructions:
Check-out time is 10 AM
Payment types
- Pets allowed for an extra charge of EUR 9 per pet, per day
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No rollaway/extra beds available
Guests must contact this hotel in advance to reserve a baby kit (bed, high chair, etc.) (surcharge). Contact the office using the information on the reservation confirmation received after booking.
- Deposit: EUR 200
- A tax is imposed by the city: EUR 1 per person, per night. This tax does not apply to children under 13 years of age.
Optional extras
- Self parking fee: EUR 26 per week
- Pet fee: EUR 9 per pet, per day
- Early check-in fee: EUR 50
- In-room safe fee: EUR 2 per day
- Crib (infant bed) fee: EUR 40.00 per week
Hotel Name
- Pierre & Vacances L'Alpaga
- Pierre & Vacances L'Alpaga Serre-Chevalier
- Pierre & Vacances Residence L'Alpaga
- Pierre & Vacances Residence L'Alpaga Serre-Chevalier


text:
Here's the good news: you can do lots of the stuff professional paleontologists do without a college degree and years of experience. You can dig and chip away at rocks to your heart's content—assuming you're not trespassing, of course. You can take notes on your findings and hypothesize yourself silly about the time period that likely produced the fossils you found.
What qualities will help you pull this off? First, you'll need a pretty active imagination to think like the dinos did, plus plenty of patience to keep hunting for fossils that don't tend to materialize on demand.
If you want to actually make cash fossil hunting, though, you'll have to get an education first (source). However, most universities don't actually offer paleontology degrees. You'll need a specific knowledge base in math and science to cut the mustard as a paleontologist; that means chemistry, physics, biology, and geology on the science end, and your math skills should go up through calculus and beyond.
You'll also need top-notch computer and data analysis skills, along with digital mapping expertise and a familiarity with satellite-based Geographic Information Systems—like a GPS but way more James Bond-y. Throw in a few communications courses, since you'll write reports and work with other professionals.
So then you're ready to get out and find your own personal T-Rex, right? Not if you're really serious about this whole thing. After all that earlier stuff, it's on to graduate school, where the fun actually starts.
You'll have to do your own independent research projects, for which you'll be accountable to a faculty adviser who probably won't cut you any slack if you try to cut corners. If you perform some valuable original research, you might find a master's or doctoral degree at the end of the excruciating slog.
After all that, you can start collecting all of those bones. Thanks for waiting.


text:
Below are links to the temperature and precipitation graphs for the previous month at Chattanooga (CHA), Knoxville (TYS), and Tri-Cities (TRI).
Please click on the links below for graphs of last month's temperature and precipitation information.
For more information about data and records, please visit the links at www.nws.noaa.gov/climate/local_data.php
For information about the one and three month Climate Prediction Center Outlooks for the upcoming months for Morristown, TN's forecast area,
please visit www.srh.noaa.gov/mrx/
For each graph below:
The observed daily maximum and minimum temperatures are connected by dark blue bars.
Area between normal maxiumum and minimum temperatures has tan shading.
Red line connects record high temperatures.
Light blue line connects record low temperatures.
Green line is precipitation accumulation for 2016.
Brown line is normal.
Blue line is accumulation for wettest period.
Red line is accumulation for driest period.
Period of record for wettest and driest:


text:
Fletcher Drive and Larga Ave (Glenhurst Park) | KCET
Fletcher Drive and Larga Ave (Glenhurst Park)
Opportunity Site
From underutilized sites to potential river access ways, these projects leverage existing resources, funding potential, and the desires of community members, to support the local neighborhoods and the revitalization of the Los Angeles River. We encourage you to leave your thoughts on the project site in the "Responses" tab.
Dangerous Pedestrian/Biking Conditions
Adjacent to Public Facility Zoned Land
Nearby to Glenhurst Park
Opportunity for River Access


text:
Number of Pieces: 1
Used For: curling, shine enhancing, Hair Styling
For Use On: Hair
Hair Type: All Hair Types
Barrel Size: 1"
Features: Digital controls, Tourmaline Coated, Quick Heat Up, Swivel Cord, Automatic Shut-Off
Material: Plastic, Ceramic
Heat Maximum: 400 Degrees Fahrenheit
Heating Time: 1
Number of Heat Settings: 1
Power Source: Electric
Care and Cleaning: Wipe Clean with a Damp Cloth
Includes: Curling iron
Battery: no battery used:
other Info.
Warranty Information
To obtain a copy of the manufacturer's warranty for this item, please call Target Guest Services at 1-800-591-3869.
- Item can be gift wrapped.
- Imported


text:
Welcome-to-the-Neighborhood Cookies RecipeRead Reviews Be the first to add a review
5 2 3
"I always share a batch of these cookies with new neighbors," says Susan Bice at Edwards Air Force Base in California. "They're easy to make but taste like I really fussed."
- 1 cup butter, softened
- 1/2 cup sugar
- 1/2 cup packed brown sugar
- 1 egg
- 2-1/4 cups all-purpose flour
- 2 to 3 teaspoons grated orange peel
- 1 teaspoon ground cinnamon
- 3/4 teaspoon baking soda
- 1/2 teaspoon salt
- Pinch ground nutmeg
- Pinch ground cloves
- 1 package (12 ounces) white baking chips
- In a bowl, cream butter and sugars; beat in egg. Combine flour, orange peel, cinnamon, baking soda, salt, nutmeg and cloves; add to creamed mixture. Stir in chips. Drop by rounded tablespoonfuls onto ungreased baking sheets. Bake at 350° for 12-14 minutes or until lightly browned. Cool on wire racks. Yield: about 3-1/2 dozen.
Originally published as Welcome-to-the-Neighborhood Cookies in Taste of Home October/November 1999, p54
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text:
The associated expression of Maspin and Bax proteins as a potential prognostic factor in intrahepatic cholangiocarcinoma
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- Romani, A.A., Soliani, P., Desenzani, S. et al. BMC Cancer (2006) 6: 255. doi:10.1186/1471-2407-6-255
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Maspin, a member of the serpin family, is a suppressor of tumor growth, an inhibitor of angiogenesis and an inducer of apoptosis. Maspin induces apoptosis by increasing Bax, a member of the Bcl-2 family of apoptosis-regulating proteins. In this exploratory study, we investigated the associated expression of Maspin and Bax proteins as a potential prognostic factor in intrahepatic cholangiocarcinoma (IHCCA).
Twenty-two paraffin-embedded samples were analyzed by immunohistochemical methods using Maspin, Bax and CD34 antibodies. Maspin was scored semiquantitatively (HSCORE). Apoptosis was assessed using an antibody against cleaved caspase-3.
The strong relationship observed between the expression of Maspin and Bax, indicates that Bax is likely to be the key effector of Maspin-mediated induction of apoptosis as indicated by the activation of cleaved caspase-3. We categorized Maspin HSCORE by calculating the optimal cutpoint. A Maspin HSCORE above the cutpoint was inversely related with tumor dimension, depth of tumor and vascular invasion. Uni/multivariate analysis suggests that a Maspin HSCORE below the cutpoint significantly worsens the patients' prognosis. Tumors with Maspin HSCORE below the cutpoint had a shorter survival (11+/-5 months) than did patients with Maspin HSCORE above the cutpoint (27+/-4 months), whereas Kaplan-Meier analysis and logrank test showed no significant difference in overall survival between the patients.
The associated expression of Maspin and Bax might delay tumor progression in IHCCA. Maspin above the cutpoint might counteract tumor development by increasing cell apoptosis, and by decreasing tumor mass and cell invasion. The combined expression of Maspin and Bax appears to influence the susceptibility of tumor cholangiocytes to apoptosis and thus may be involved in delaying IHCCA progression.
Cholangiocarcinoma is a rare tumor that is difficult to diagnose and is associated with a high mortality [1–3]. The term cholangiocarcinoma referred originally to just primary tumors of the intrahepatic bile ducts, while now it is regarded as inclusive of intrahepatic, perihilar, and distal extrahepatic tumours of the bile ducts [4]. The incidence of intrahepatic bile duct carcinoma (IHCCA) is increasing worldwide, although the cause for this rise is unclear [1, 2]. It could be related to an interplay between predisposing genetic factors and environmental triggers. Surgical resection is the only curative option for cholangiocarcinoma, particularly for extrahepatic ones, with results depending on technique and patient selection [5–9]. Chemotherapy and radiotherapy are ineffective in patients with inoperable tumors. and biliary drainage is the mainstay of palliation [10, 11]. Over the last ten years, considerable effort has been devoted to the search for markers to improve the diagnosis and the management of CCA. One of the authors (AAR) has developed a Perl [12] script for differential in silico screening between cancer and normal EST tissue libraries devoted to the identification of differentially expressed genes. Expressed Sequence Tag (EST) sequencing [13] is of value in discovering new genes (or rather markers), and provides an inexpensive approach to identifying large numbers of new genes [14, 15]. These can be used in gene differential expression screening procedures. The widely recognized contribution of ESTs to gene discovery has spurred the production of very large numbers of these sequences. There are currently over 6.0 × 106 human EST sequences in the public databases [16] and ESTs represent more than 60% of the Gene Bank database entries. Using this procedure, a pool of mRNA sequences were identified that, on a statistical basis [17, 18], are preferentially expressed in hepatocarcinoma and cholangiocarcinoma (data not shown). We focused our attention on those over-expressed genes known to counteract or delay tumor progression. Among these genes, we selected the Maspin gene whose protein product belongs to the family of protease inhibitors, and has been described as an apoptosis-sensitizing protein [19].
Maspin (mammaryserineproteaseinhibitor) is a member of the serpin (serineproteaseinhibitor) family [20, 21] and has recently been described as a clinically relevant factor in several types of tumor [22–25]. A decreased expression of Maspin has been related to the progression of breast cancer, and the loss of its expression is regarded as a critical step during the transition from non-invasive to invasive breast cancer [26, 27]. It has been suggested that Maspin could be a reliable predictor for metastatic disease [28] and a clinical relevant inhibitor of tumor progression [29].
The mechanism of Maspin action is still controversial and it could act as an inhibitor of angiogenesis[30, 31], and suppressor of tumor growth and metastasis in vivo [32, 33]. There is increasing evidence that in addition to its anti-angiogenic effect, Maspin can induce apoptosis of tumor cells. Moreover, Maspin over-expression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins [34] resulting in an increased release of cytochrome C from mitochondria [35] and an increased apoptosis in Maspin-expressing cells [36]. Other work showed that in Maspin- expressing cells, the Bcl-2 level was decreased and the level of pro-apoptotic protein Bax was significantly increased In a recent study [19], the authors obtained cellular, molecular, and biochemical evidence that supports a key role for Bax in sensitization of Maspin-mediated apoptosis. Thus, Bax over-expression may predict an elevated cellular apoptotic response to a broad spectrum of apoptotic stimuli.
To our knowledge, the combined role of Maspin and Bax in IHCCA has been not investigated. The aim of this exploratory study was to assess the associated expression patterns of Maspin and Bax in specimens of IHCCA and to investigate whether Maspin and Bax might be used as novel prognostic factors.
Patient selection
From January 1997 to December 2005, 33 patients affected by cholangiocarcinoma were admitted to the Surgery department. Five patients did not undergo surgery because of advanced disease, advanced liver cirrhosis or poor general condition. The remaining 28 patients (9 males and 19 females) with an average age of 68 years (range: 36–79), underwent liver resection for cholangiocarcinoma at the Dipartimento di Scienze Chirurgiche, Sezione di Clinica Chirurgica Generale e dei Trapianti d'Organo. Of these 28 patients, 22 had IHCCA and six patients had hilar extrahepatic cholangiocarcinoma (Klatskin): 3 patients of type IIIb, 2 had a peripheral type and one had a periductal type according to the Bismuth-Corlette indication.
We focused our attention on IHCCA, since the epidemiological data, retrieved from the Parma Tumor Registry (Divisione di Oncologia Medica, Azienda Ospedaliera di Parma), showed a marked increase in IHCCA in our province from 1–2 cases/year in 1994 to 9–12 cases/year in 2002–2004.
Background information including clinico-pathologic data, and patients' survival was retrieved from histologic and clinical records. None of the patients had received chemotherapy or radiotherapy prior to surgery. All surgical procedures were performed with radical intent (R0 after surgery). Liver needle biopsies of five patients included in this study were available.
The study was conducted in accordance with the tenets of the Declaration of Helsinki. Following the indication of Italian DLgs no. 196/03 (Codex on Privacy), every precaution has been taken to respect the privacy of the patients and the confidentiality of the patient's information. Written consent to use stored tissue was obtained from all the living patients.
Sample sources
The samples were retrieved from the archived files of the Dipartimento di Patologia e Medicina di Laboratorio – Sezione di Anatomia ed Istologia Patologica. Formalin- fixed, paraffin-embedded, hematoxylin-eosin-stained sections were reviewed and the pathologist (PC) re-staged the samples according to the recent AJCC classification [37]. Sections with poorly differentiated tumor areas with adjacent normal and/or dysplastic tissues were then selected for immunohistochemical studies.
The paraffin sections were dewaxed, rehydrated, washed in Tris-buffered saline (TBS) (150 mmol/L NaCl, 50 mmol/L Tris, pH 7.4). The antigen determinants masked by formalin-fixation and paraffin-embedding were exposed by heating the section in a microwave oven for 10 min in an epitope retrieval solution (10 mM Tris Base, 1 mM EDTA solution, 0.05% (v/v) Tween 20, pH 9.0). The sections used for the pan-endothelial-cell marker CD34 were treated with 1 mg/ml protease type XXIV [38] (Sigma-Aldrich, Inc., St. Louis, MO). The endogenous peroxidase activity was quenched with 3% H2O2 in deionized water for 10 min. Non-specific bindings were blocked in TBS containing 5% acetylated albumin (Aurion, Wegeningen, The Netherlands), 5% normal mouse serum (Dako Corp., Carpinteria, CA) and 0.1% porcine gelatin type B (Sigma-Aldrich). The primary antibodies against Maspin (Novocastra, Newcastle upon Tyne, UK), Bax and CD34 (Santa Cruz Biotechnology, Inc. Santa Cruz, CA), and cleaved caspase-3 (Cell Signaling Technology Inc., Beverly, MA) were used at 1:35, 1:75, 1:50 and 1:200 dilutions, respectively. Immunoperoxidase staining was performed using an anti-Mouse/Rabbit Poly HRP Detection Kit (Chemicon International, Temecula, CA) according to the manufacture's specifications and developed with DAB. The specimens were counterstained with hematoxylin, mounted and examined by light microscopy. Routine negative controls used TBS instead of the primary antibody. An isotype control was conducted using a mouse IgG isotype control serum (Dako Corp., Carpinteria, CA). Negative and isotype controls were used in all staining runs. All negative and isotype controls resulted in negative immunohistochemical reactions. Adjacent normal and/or dysplastic areas were selected as internal controls. As positive controls, sections from tumors known to express Maspin and/or Bax were used (according to the manufacture's datasheet). A preparation of excised inflammatory tonsils was used to asses cleaved caspase-3 expression.
The staining intensities of the IHCCAs and liver fine-needle biopsies were compared with those of adjacent non-neoplastic biliary ducts and by semiquantitative visual evaluation by three observers (PC, AAR and SD). Overexpression was considered to be present when the intensity of tumor staining was at least twice the staining intensity of adjacent non-neoplastic areas.
Image analysis
The expression of Maspin was evaluated using a microscope image analysis system (Nikon Digital Net system). For each patient, five randomized, non-overlapping rames were evaluated in the same neoplastic area at 400× field magnification (0.198 mm2·field). At least 50 cells were counted for a total of 250–500 cells analyzed. Toassess reproducibility of the image analysis, the pathologist (PC) blindly scored the 66% of the total of patients and also randomly selected frames.
Quantification of expression
Maspin and Bax immunopositivities were semi-quantitatively evaluated. This method described by McCarty [39] is referred to as HSCORE. The percentage of positive cells for Maspin or Bax, respectively, was linked with the intensity of staining classified into four groups: 0-negative; 1-slight positive (light brown color of the either homogeneously or spotty stained cells); 2-distinct positivity (medium brown homogeneously stained cells); 3-strong positivity (dark brown to black homogeneously stained cells).
We calculated the HSCORE using this formula:
HSCORE = ∑Pi·(j+1),
where Pi is the percentage of positive cells in the sample investigated, and j is one of the four positivity grades (0–3) defined above.
Quantification of neoplastic cells expressing cleaved caspase-3
Cleaved caspase-3 positive neoplastic cells were quantified using a microscopic grid at 400× magnification and expressed as percentages of all tumor cells present. Moreover, we carefully separated cleaved caspase-3 positive lymphocytes and intratumoral macrophages from phagocytosed apoptotic debris. Apoptotic cells from highly necrotic areas were excluded from the analysis.
Evaluation of microvessel density
The procedure used was in accordance to the international consensus method of intratumoral microvessel density assessment [40] by using the pan-endothelial CD34 marker. The assessment was conducted according to our recently published procedure [41]. For microvessel quantitation, the tumoral areas containing the highest number of capillaries and small vessels were identified by light microscopy at low power magnification. In each tumor, three areas with the highest vascularization were identified, and a microvessel count was performed at x200 magnification. Although agreement was not exact in every case, no significant variation between the investigators' counts (PC, AAR, SD) was noted.
Statistical analysis
The biomarker and clinical data were analyzed using S-Plus Professional Edition v.6.1 (Insightful Corp., Seattle, WA). Fisher's Exact Test was used to test the hypothesis of independence between categorical variables in 2 × 2 tables. The ANOVA procedure was used to evaluate the association between ordinal and categorical variables. All tests were two-sided. The significance values higher than 0.05 and less than 0.10 indicated a trend. The conversion of a continuous covariate into a binary one when there is no established cut-off point (previous published results or biological knowledge) was performed by using an outcome-oriented statistical method (such as the optimal cutpoint estimation).
For optimal cutpoint estimation a corrected P value method, as described by Hothorn and Lausen [42], was used. Estimates of the survival probability were calculated using the Kaplan-Meier method, and the logrank test was employed to test the null hypothesis of equality in overall survival among patients with Maspin above or below the cutpoint. The hazard ratio associated with Maspin expression above or below the cutpoint was estimated by logistic regression.
Demographic data
This exploratory study concerned a relatively short period of inclusion (7 years) for this tumor, with a satisfactory homogeneity of patients treated with radical intent. T3he average age of the 15 females and 7 males undergoing surgery for IHCCA was 68 years (range 52–79). Two patients out of 22 were positive to C viral hepatitis (one of them showed B and C infection). None of the other patients had chronic liver disease. At presentation, twelve patients had one comorbidity (diabetes, hypertension or heart disease), eight patients had two comorbidities (mainly diabetes and hypertension), and only two patients had three comorbidities (chronic obstructive lung disease, diabetes and heart disease).
The surgical procedures, performed by one of the authors (PS), for IHCCA included: 5 right trisectionectomies, 4 right and 3 left hemihepatectomies (including the extended), 7 sectoriectomies (anterior, posterior and lateral) and 3 segmentectomies. The mean liver volume removed was 49 ± 19.2% (range 22–75%) while 4.5 ± 1.5 were the mean number of resected hepatic segments.
Clinical-pathological features of patients affected by CCA who underwent surgery
Patients with Maspin HSCORE above cutpoint (N = 13)
Patients with Maspin HSCORE below cutpoint (N = 9)
Age at surgery
69.3 + 7
67.3 + 10.3
Tumor greatest dimension
<4 cm
4–6 cm
>6 cm
Histologic grade
Percentage of tumor necrosis1#
Peritumoral border liver1#
Lymphoid infiltration1
Immunohistochemical detection of Maspin, Bax and cleaved Caspase-3
The immunohistochemical staining, performed with anti-Maspin, anti-Bax monoclonal antibody and anti-cleaved-caspase 3 polyclonal antibody respectively, produced readily quantifiable results.
The Maspin immunopositivities were semi-quantitatively evaluated as described in the Methods section. Maspin HSCORE ranged from 0 to 181.1 with a mean value of 71.3 ± 63.7 (median 69.7). The standardized skewness and kurtosis values (0.723 and -1.426, respectively) are within the range expected for data from a normal distribution.
Maspin is regarded as an apoptosis-sensitizing protein [19]. The link between Maspin expression and apoptosis induction has been explained by the regulation of pro- apoptotic Bcl-2 family proteins [34], resulting in predominantly increased Bax expression.
Bax immunostaining was cytoplasmic and homogeneous. We observed clear-cut expression of Bax in 45.5% (10/22) of the evaluated specimens. In positive samples, it was expressed in more than 75% of the neoplastic cells (see Figure 1B,D). Interestingly, when Bax was expressed we always observed Maspin expression (P- value = 0.039). Bax HSCORE ranged from 0 to 248.1 with a mean value of 67.9 ± 96.5. Only the kurtosis value (0.036) was within the range expected for data from a normal distribution.
In Bax-positive samples, cleaved caspase-3-positive infiltrating lymphocytes were detected, serving as an internal positive control. In some cases, granular cytoplasmic staining in macrophages was also observed, probably representing phagocytosed apoptotic debris.
Statistical correlation between Maspin HSCORE and clinical characteristics
Similarly (see Figure 5B), the Maspin HSCORE was significantly related to the depth of tumor invasion (P-value = 0.043). The mean values of Maspin HSCORE for each pT-stage were respectively: pT1 = 129.54 ± 25; pT2 = 68 ± 25; pT3 = 48 ± 16.
It is widely accepted that necrosis is frequently associated with the tumor mass. However, and in contrast to the relation of Maspin with tumor mass, we did not find any significant relation to the extent of the necrosis (P-value = 0.550). As expected, in our cohort of patients the tumor mass was significant related to the vascular invasion (P-value = 0.0018) (Figure 5C). We examined whether Maspin over- expression affected vascular invasion in IHCCA. Our results indicated an absence or presence of vascular invasion when Maspin was above or below the cutpoint, respectively (P-value = 0.027) (Figure 5D). The Maspin HSCOREs were 98.3 ± 16 and 39 ± 18 in the absence or in the presence of vascular invasion, respectively. Moreover, the Maspin HSCORE was not related to dysplasia of the intrahepatic bile ducts close to neoplastic lesions, nor with the extent of lymphoid cell infiltration (not shown).
We also wished to verify the potential role of Maspin as an angiogenic inhibitor [30] by evaluating the relation between Maspin expression and microvessel density. The CD34-positive vessel count ranged from 7.5 to 54.4 vessels·mm with a mean value of 34.8 ± 14.1 (median 38). The standardized skewness and kurtosis values (-0.893 and -0.888, respectively) lay within the range expected for data from a normal distribution.
The patients with Maspin HSCORE above the cutpoint had a mean value of CD34- positive vessels of 36.5 ± 14.2 (median 41 vessels) and those below cutpoint had a mean of 32.4 ± 14.3 (median 34 vessels) (P-value = 0.5170) indicating a lack of statistical significance.
We finally evaluated the role of Maspin as a prognostic factor [43, 44]. The patients who underwent surgery during the last year of enrolment and still alive were excluded from the survival analysis. This choice was supported by the fact that the follow-up period of these patients was shorter than the median length of IHCCA overall survival (18–30 months) [2, 45]. The patients with a Maspin HSCORE below the cutpoint had a shorter overall survival (14 ± 10 months) than did patients with Maspin HSCORE above the cutpoint (27 ± 18 months), whereas the log-rank test showed no significant difference between the two groups of patients (P-value = 0.162). Moreover, in the evaluation of the relation between Maspin and/or Bax expression and survival there were no statistically significant differences between the three groups (Logrank test P-value = 0.483): 37.3 ± 5.7 (Maspin+/Bax+), 27.2 ± 7.5 (Maspin+/Bax-), 21.7 ± 3.9 (Maspin-/Bax-) months, respectively. It should be noted, however that the tumors with an absence of both Maspin and Bax had the shortest mean overall survival.
Multivariate logistic regression analysis.
Multivariate Logistic Regression
Prognostic factors
Adverse Factor
Tumor greatest dimension
Maspin HSCORE
Resected margins'invasion
Glisson's capsule invasion
There is good experimental evidence that Maspin abolishes tumor invasion [46], induces tumor re-differentiation [47, 48] and also enhances sensitivity of tumor cells to apoptosis by inducing the apoptogenic Bax protein [19, 34, 36, 48]. Furthermore, suppression of Maspin expression by siRNA desensitizes tumor cells to apoptosis [35].
It has been reported that the apoptosis-sensitizing effect of Maspin resulted predominantly from increased Bax expression causing mitochondrial release of apoptogenic factors such as cytochrome C and Smac/DIABLO [19].
We show here that Bax was expressed only when Maspin reached a threshold value (cutpoint). We concluded that Bax expression consequent to a Maspin level above the cutpoint, shifted the relative concentration of anti- versus pro-apoptotic members of the Bcl-2 family, thus acting as a positive modulator of the death program. In our IHCCA specimens, however, the concomitant occurrence of Maspin and Bax did not correlate with a better prognosis. In a recent paper [49], the over-expression of Bax in lung cancer specimens suggested a pro-apoptotic cellular tendency that did not correlate with a better prognosis. In contrast, it has been shown [50] in metastatic breast adenocarcinoma, that the expression of Bax protein is associated with increased overall survival and better response to chemotherapy. However, a negative prognostic role of Bax expression has been described in non-small-cell lung cancer [51]. Despite these contradictory results on the role of Bax as a prognostic factor, its induction in Maspin-over-expressing specimens seems to represent an important mechanism by which Maspin delays tumor progression and invasion.
The results presented here show for the first time that the associated expression of Maspin and Bax, detected by immunohistochemistry, significantly correlated with a less aggressive phenotype. Thus, Maspin expression above the cutpoint and the consequent Bax induction can help to explain observations of opposite relations with neoplastic mass, depth of tumor invasion, and vascular invasion. However, it should be noted that Maspin expression was not related with the dysplasia of intrahepatic bile ducts close to the neoplastic lesion, lymphoid cell infiltration, and the extent of necrosis of tumor mass.
We did not find any significant relation between microvessel density and Maspin expression, although somewhat more CD34-positive vessels were observed in those patients with Maspin above the cutpoint. This lack of relation is in contrast with studies showing that Maspin inhibits angiogenesis [52] in vitro and in vivo in several types of tumor. Due to its antiangiogenic effect Maspin has been described as a tumor-suppressor protein. However, our results and a recent report [23] on the expression of Maspin in non-muscle invasive urothelial bladder carcinoma suggest that in IHCCA and some other tumors Maspin may exhibit its tumor-suppressor role by a mechanism unrelated with angiogenesis. Interestingly, it has been shown that tumor neo-vessels become leaky after Maspin treatment [31], whereas normal mature vessels are not affected by Maspin treatment. In addition, it should be noted that our CD34-antibody, a pan-endothelial marker, used to highlight vasculature reveals mainly pre-existing mature vessels and not tumor-induced neovessels.
The caspase-3 activation was found related to the Bax expression in the majority of IHCCA specimens. Interestingly, in all tumor areas with activated caspase-3, a concomitant overexpression of Maspin and Bax was always found. A subset of IHCCA had Bax overexpression without a concomitant activated caspase-3 in tumor cells. A similar finding has been reported in a tumorigenic epithelial cell line [53]. An arrest of the intrinsic apoptotic pathway could occur by different mechanisms such as the impediment of the Bax pro-apoptotic conformational change [36], overexpression of Bax-inhibitor [54], or the prevention of the caspase cascade attributed to overexpression of heat shock proteins (mainly HSP27) [55].
The univariate logistic regression analysis has shown that the factors significantly involved in the risk of death in IHCCA are: staging and Maspin HSCORE. As shown in Table 2, the multivariate logistic analysis indicated that stage, Maspin HSCORE and resected margins' invasion are independent factors for the risk of death. Univariate and multivariate logistic analyses suggest a clear-cut relation between the increased Maspin HSCORE and probability to survive. Our results suggest that a routine assessment of Maspin expression by immunostaining in IHCCA might help detect those patients with a higher risk of death. They are also consistent with the hypothesis, recently described for other types of tumor [43, 44, 56, 57], that reduced/absent Maspin expression may predispose to an increased risk of death. The non-parametric estimates of survival for Maspin HSCORE cutpoint indicate that the mean survival for those patients with HSCORE above the cutpoint was related with longer overall survival although the logrank test showed no significant difference in survival between the patients.
The prognostic relevance of Maspin expression is a matter of debate. For instance, some authors have described Maspin expression as a prognostic marker for several tumors [25, 34, 44, 56–60]. In contrast, other authors feel that Maspin expression [23, 61] or overexpression [62] is not a promising prognostic marker.
We also examined Maspin expression on the available liver needle biopsies. Our results (not shown) suggest that immunohistochemical negativity for Maspin clearly indicates a neoplasm with a clinically aggressive course. On the other hand, the immunopositivity is less informative since we cannot exclude the presence of Maspin- negative areas with a lesser degree of differentiation and with aggressive potential.
Our study has the limitation of a low number of patients that is too small to draw valid conclusions or conduct further statistical analysis. The probability of correctly rejecting the null hypothesis (Power of test [63]) did not reach the required amount of power. However, our cohort represents a large single institution series given the rarity of this tumor.
A multicentric and randomized trial will be required to validate our results performed in this explorative retrospective study. If confirmed in a large independent trial, the expression of Maspin should help to discriminate IHCCA patients with a better prognosis. Moreover, pre-operative information retrieved from liver needle biopsies could provide a basis for enroling those patients with a likely unfavorable course for intensive pre-operative management. Finally, it should help devise novel strategies for inducing Maspin expression in IHCCA tumor cells. This procedure could restore tumor cell sensitivity towards a broad range of apoptosis-inducing therapeutic interventions designed to delay tumor progression.
Maspin expression is negatively associated with IHCCA progression when Bax is expressed. The combined expression of Maspin and Bax may influence the susceptibility of tumor cholangiocytes to apoptosis (as observed by increased caspase-3 expression) and therefore may be involved in delaying IHCCA progression. Procedures designed to induce Maspin expression in IHCCA could restore tumor cell sensitivity towards a broad range of apoptosis-inducing therapeutic interventions and delay tumor progression.
We wish to thank the reviewers for their criticisms and suggestions that undoubtedly improved the scientific content of this manuscript. We wish to thank also Drs. Sara Tacci and Hassan Fahrad for their valuable assistance in retrieving and collecting patients' data, Miss Gabriella Becchi for her precious technical assistance and Dr. Cristina Mancini for her criticism and photographic expertise. This study was supported by FIL grants from MIUR (Rome, Italy).
Supplementary material
Copyright information
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Opened 4 years ago
Closed 3 years ago
#18160 closed Bug (duplicate)
Auth - Unknown Encoding Error when syncdb
|Reported by:
|Owned by:
|Triage Stage:
|Has patch:
|Needs documentation:
|Needs tests:
|Patch needs improvement:
|Easy pickings:
Description (last modified by jezdez)
When I was running ./manage.py syncdb (with sqlite3), a LookupError shows up
as follow. I filed a patch to fix it.
In the UnitTest, I made import locale as inline (Or should I import it at
the beggining of the file?)
bash $ ./manage.py syncdb Creating tables ... Creating table auth_permission Creating table auth_group_permissions Creating table auth_group Creating table auth_user_user_permissions Creating table auth_user_groups Creating table auth_user Creating table django_content_type Creating table django_session Creating table django_site Creating table django_admin_log You just installed Django's auth system, which means you don't have any superusers defined. Would you like to create one now? (yes/no): yes Traceback (most recent call last): File "./manage.py", line 13, in <module> execute_from_command_line(sys.argv) File "/Users/yippee/projects/YEditor/server/django/core/management/__init__.py", line 443, in execute_from_command_line utility.execute() File "/Users/yippee/projects/YEditor/server/django/core/management/__init__.py", line 382, in execute self.fetch_command(subcommand).run_from_argv(self.argv) File "/Users/yippee/projects/YEditor/server/django/core/management/base.py", line 196, in run_from_argv self.execute(*args, **options.__dict__) File "/Users/yippee/projects/YEditor/server/django/core/management/base.py", line 232, in execute output = self.handle(*args, **options) File "/Users/yippee/projects/YEditor/server/django/core/management/base.py", line 371, in handle return self.handle_noargs(**options) File "/Users/yippee/projects/YEditor/server/django/core/management/commands/syncdb.py", line 110, in handle_noargs emit_post_sync_signal(created_models, verbosity, interactive, db) File "/Users/yippee/projects/YEditor/server/django/core/management/sql.py", line 189, in emit_post_sync_signal interactive=interactive, db=db) File "/Users/yippee/projects/YEditor/server/django/dispatch/dispatcher.py", line 172, in send response = receiver(signal=self, sender=sender, **named) File "/Users/yippee/projects/YEditor/server/django/contrib/auth/management/__init__.py", line 73, in create_superuser call_command("createsuperuser", interactive=True, database=db) File "/Users/yippee/projects/YEditor/server/django/core/management/__init__.py", line 150, in call_command return klass.execute(*args, **defaults) File "/Users/yippee/projects/YEditor/server/django/core/management/base.py", line 232, in execute output = self.handle(*args, **options) File "/Users/yippee/projects/YEditor/server/django/contrib/auth/management/commands/createsuperuser.py", line 70, in handle default_username = get_default_username() File "/Users/yippee/projects/YEditor/server/django/contrib/auth/management/__init__.py", line 105, in get_default_username default_username = get_system_username() File "/Users/yippee/projects/YEditor/server/django/contrib/auth/management/__init__.py", line 85, in get_system_username return getpass.getuser().decode(locale.getdefaultlocale()[1]) LookupError: unknown encoding: x-mac-simp-chinese
Attachments (2)
Change History (7)
Changed 4 years ago by mitnk
comment:1 Changed 4 years ago by jezdez
- Description modified (diff)
- Needs documentation unset
- Needs tests unset
- Patch needs improvement unset
Fixed traceback.
comment:2 Changed 4 years ago by jezdez
- Triage Stage changed from Unreviewed to Accepted
comment:3 Changed 4 years ago by jezdez
- Triage Stage changed from Accepted to Ready for checkin
comment:4 Changed 4 years ago by mawe
- Triage Stage changed from Ready for checkin to Accepted
While the original patch fixes the issue with an invalid encoding, it does not address the problem completely. There also seem to be many duplicate tickets regarding this issue (search for getdefaultlocale), but it seems like the easiest fix would be to simply use django.utils.encoding.DEFAULT_LOCALE_ENCODING, as in the attached patch auth_invalid_encoding.diff
Changed 4 years ago by mawe
Updated patch which fixes unknown as well as invalid (None) encodings
comment:5 Changed 3 years ago by claudep
- Resolution set to duplicate
- Status changed from new to closed
Was fixed in #19933


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Posted| Updated
The man involved in a 14-hour stand-off with police at his home in a southern Canberra suburb has appeared in the ACT Magistrates Court.
Topics: police-sieges, courts-and-trials, police, canberra-2600, act, australia
The Riverina Water County Council says it is lifting water charges because of rising operating costs and the need for millions of dollars of new infrastructure.
Topics: water-management, water, wagga-wagga-2650
Tennant Creek police have charged a 42-year-old man in relation to a glassing assault on Wednesday night.
Topics: assault, law-crime-and-justice, courts-and-trials, crime, alice-springs-0870, australia, nt
Posted| Updated
Angry home insulation installers affected by the axing of the Federal Government's rebate scheme have returned to Parliament House to demand payment from the Commonwealth.
Topics: industry, federal-government, canberra-2600, act, australia
Posted| Updated
The Redbacks appoint Michael Klinger as captain and Callum Ferguson as deputy.
Topics: cricket, sport, adelaide-5000, australia, sa
Mourners at an Essendon church are attending the funeral of gangland figure Carl Williams who was killed in prison.
Posted| Updated
Thousands of people will be in Barcaldine this weekend for the town's annual Tree of Knowledge Festival.
Topics: community-and-multicultural-festivals, community-and-society, barcaldine-4725, qld, longreach-4730, mount-isa-4825
Lavarack Barrack's 4th Field Regiment will celebrate its 50 year history with a freedom of entry parade along Townsville's Strand tomorrow.
Topics: community-and-multicultural-festivals, community-and-society, defence-and-national-security, defence-forces, army, townsville-4810, australia, qld
Newmont Mining says an increase in copper and gold prices and a boost in production at its new south-west Western Australian gold mine has seen the company double its first quarter profit.
Topics: company-news, business-economics-and-finance, industry, copper, gold, bunbury-6230, australia, wa
Police in south-west Western Australia have expressed concern over a proposal to reschedule an annual music festival in Busselton.
Topics: community-and-multicultural-festivals, community-and-society, law-crime-and-justice, police, busselton-6280, australia, wa, bunbury-6230
A Senate committee report into the proposed nuclear waste dump at Muckaty Station, north of Tennant Creek, has been delayed.
Topics: nuclear-issues, federal---state-issues, darwin-0800, australia, alice-springs-0870, nt, tennant-creek-0860
Posted| Updated
Moral panic is our new chosen hobby and it only stands to reason that anyone as popular as Justin Bieber should function as its glue.
Topics: arts-and-entertainment, community-and-society, person
Posted| Updated
The Australian women's hockey team is a step closer to securing a berth at this year's World Cup after thrashing Malaysia 9-0 in a qualifying tournament in Chile.
Topics: field-hockey, sport, chile, australia, malaysia
A massive crowd is expected to turn out for the 2010 Busselton Half Ironman tomorrow.
Topics: event, busselton-6280, australia, wa, bunbury-6230
Posted| Updated
Unions representing workers at Rio Tinto Alcan's Gove site say staff have been trying for years to get the company to do something about regular spills of alumina that go unreported.
Topics: water-pollution, unions, nhulunbuy-0880, australia, nt, darwin-0800
Posted| Updated
Macquarie Group says the recovery in market conditions and trading led to its 21 per cent net profit rise this year.
Topics: company-news, business-economics-and-finance, australia
A 53-year-old man has pleaded not guilty to illegally filming and recording his employees at a Goldfields' mine-site.
Topics: sexual-offences, law-crime-and-justice, courts-and-trials, crime, kalgoorlie-6430, australia, wa
Posted| Updated
Hundreds of workers have held a farewell barbecue at tyre maker Bridgestone's factory in Adelaide.
Topics: automotive, business-economics-and-finance, company-news, industry, salisbury-5108, australia, adelaide-5000, sa
Posted| Updated
QantasLink direct flights from Cairns to Port Moresby are expected to start in a matter of months.
Topics: air-transport, business-economics-and-finance, industry, cairns-4870, australia, qld
The Wollongong Police Association says it is fed up with alcohol-fuelled violence caused by the unrestricted opening hours of some clubs and pubs.
Topics: crime, drugs-and-substance-abuse, government-and-politics, states-and-territories, law-crime-and-justice, antisocial-behaviour, assault, police, wollongong-2500, australia, nsw
Posted| Updated
The public broadcasters - ABC and SBS - are now moving within funding constraints to expand services in free to air digital multi-channelling.
Topics: broadcasting, information-and-communication, abc, radio-broadcasting, television-broadcasting, australia
A 19-year-old Geraldton man, who escaped a jail term after desecrating graves at a local cemetery, has breached the conditions imposed on him by the court.
Topics: courts-and-trials, crime, vandalism, geraldton-6530
Guards at Greenough Regional Prison are demanding urgent action to address what they say is chronic overcrowding at the facility.
Topics: prisons-and-punishment, work, states-and-territories, greenough-6532, geraldton-6530
A Tasmanian man has admitted holding up a Bridgewater service station with a metal pipe, saying it was a moment of stupidity after drinking two cartons of beer.
Topics: armed-robbery, crime, bridgewater-7030, tas
Posted| Updated
It is hoped a new heritage listing will recognise the influence of French explorers on Tasmanian history.
Topics: 19th-century, southport-7109, tas


text:
Definition of Obama, Barack in English:
Obama, Barack
(1961-), 44th president of the US, since 2009; full name Barack Hussein Obama. A Democrat, he was the first African American to be elected to the presidency, and was re-elected in 2012 for a second term. Nobel Peace Prize (2009).
For editors and proofreaders
Syllabification: O·ba·ma, Barack
Definition of Obama, Barack in:
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text:
- Report: #1036013
Report - Rebuttal - Arbitrate
Complaint Review: Resume Genius
Resume GeniusResume Genius 10929 Wickshire Way North Bet Internet United States of America
Resume Genius Deceptive Business Practices=RIPOFF! NEVER USE THEM unless you have money to throw away Internet
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When you contact them there is no phone available only a live chat ["Betty" on my case,] who states that their "system" does not give refunds and apologizes for the inconvenience. It is not an inconvenience it is a RIP-OFF!
I hope my $60 is that last $60 they steal from any other consumer. DO NOT USE RESUME GENIUS.
This report was posted on Ripoff Report on 03/19/2013 08:21 AM and is a permanent record located here: http://www.ripoffreport.com/r/Resume-Genius/internet/Resume-Genius-Deceptive-Business-PracticesRIPOFF-NEVER-USE-THEM-unless-you-have-money-1036013. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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A Campbellsville teenager has been arrested and charged with assaulting a police officer.
Daniel Richardson, 19, of 102 S. Carden St. was arrested at about midnight Sunday, July 6.
According to an arrest citation, Campbellsville Police received a complaint that Richardson was intoxicated in a Minit Mart parking lot on East Broadway.
According to court records, Campbellsville Police Officer Brian Morgan contacted Richardson and found him cursing and being loud and combative.
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Skier Programs
Overview: A look at the Long Term Athlete Development (LTAD) model, by Head Coach Dave Wood.
Jack Rabbits Ski Lessons - Bunnies (Active Start) and Jackrabbits (FUNdamentals): A fun cross country ski program for kids ages 3-12
Track Attack (Learn to Train): the next step in skier progression after Jackrabbits. Aged 10 and up. Kids continue to develop skills through skiing and games. And those interested attend races.
Racing Teams (Train to Train / Train to Compete): For skiers aged 13-18 interested in cross-country ski racing. Follow us on our blog! www.blackjackskiteam.wordpress.com
Black Jack Nordic Academy & Red Ski Academy: For athletes aged 13-18 years who want state-of-the-art coaching and innovative educational options to meet their unique training and competitive needs
Biathlon: For skiers aged 8 years and up who are interested in the exciting sport of Biathlon, which combines cross-country skiing and target shooting.
Adult Instruction: Adult ski lessons and coaching
For comprehensive program information for all skier development programs and to register please visit www.blackjackskiteam.com


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- Report: #790181
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Complaint Review: Washington Blvd Motors
Washington Blvd Motors3210 10th St N Internet United States of America
Washington Blvd Motors DONT GO HERE! Internet, Internet
*UPDATE Employee: Please contact us
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DO Not go HERE! They are very friendly when your interested in purchasing a vehicle but when it comes to making arrangements and sticking to them they are HORRIBLE. I had to go through a horrible ordeal just to get my hard tags. It was excuse after excuse from everyone. Then I was having some mechanical issues with my vehicle , mind you I still had temp tags not even 30 days old and I mentioned it to the tag n title person I was told I brought the car it is not their problem its mine. Im giving you a fair warning DO NOT GO HERE! Go somewhere else. I will continue to post everywhere I can to let them know that you cant treat people llike anything. They were rude and very unprofessional. When I asked to speak with the owner I was told he wasnt there numerous times. Time after time. When I mentioned that my transmission was slipping and that I was going to take it to the Lexus dealership, I was told No bring it to their mechanice<<<<< Yeah right so they can tell me that everything is fine.. They will lie and do anything that they can to get away with whatever it is they are trying to do. DONT go to Washington Blvd Motors in Arlington, VA !
They state:
"Washington Boulevard Motors is a small used car dealership with a helpful staff that answers questions in a straightforward manner."<<<<<<<< LIES ALL LIES THEY ARE THE TOTAL OPPOSITE!
This report was posted on Ripoff Report on 10/18/2011 11:38 AM and is a permanent record located here: http://www.ripoffreport.com/r/Washington-Blvd-Motors/internet/Washington-Blvd-Motors-DONT-GO-HERE-Internet-Internet-790181. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 UPDATE Employee
Please contact us
AUTHOR: Ali Nezam - (United States of America)
SUBMITTED: Saturday, November 19, 2011POSTED: Saturday, November 19, 2011
If an employee of our organization has treated you rudely or has behaved in an unprofessional way I am very interested in finding out about it. There is no room in our organization for treating our clients poorly. Please feel free to call me at +17032434466 ext. 100, or email me at firstname.lastname@example.com , so that I can personally apologize, and make sure this type of behavior does not repeat in the future. Very kind regards, Ali Nezam General Manager Washington Blvd. Motors
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Family Practitioner, Primary Care Doctor, Internist
50 years of experience
50 years of experience
1605 Whipple Rd
Hayward, CA 94544 Phone number & directions
Hayward, CA 94544 Phone number & directions
License & Identifications
A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor's specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).
Learn more about Dr. Joseph Ippolito:
View the full profile to get information on:
- Qualifications
- What's important to you
View full profile
Patient Reviews
Have you visited Dr. Ippolito? Share your experience.
Write a Review
Write a Review
Prepare before visiting Dr. Ippolito
Diabetic Macular Edema Read all about Diabetic Macular Edema by visiting our Vitals patient education guides.Before Visiting Dr. Ippolito Learn More
Education & Awards
Dr. Ippolito graduated from University of California at Irvine.
Home > Find a Family Doctor > CA > Hayward Family Physicians > Dr. Joseph Ippolito, MD
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- Additional Information
- Dr. Joseph William Ippolito MD is a male Family Practitioner, has 50 years of experience and practices in Family Medicine and Internal Medicine.
- Where does Dr. Joseph W. Ippolito practice?
- Dr. Joseph Ippolito has 1 office location.
Dr. Joseph Ippolito practices Family Medicine and Internal Medicine near Hayward, CA.
See Hayward Family Physicians and Hayward Internists.


text:
Nov. 3, 2012
The Minnesota men's tennis team continued its successful weekend on the third day of the Gopher Invitational. In total, the Gophers pulled out an undefeated run on the day, going 3-0 in singles and 2-0 in doubles competition at the Baseline Tennis Center.
The Maroon and Gold continued its sweep in the doubles competition with two wins over DePaul teams. Rok Bonin and Mathieu Froment pushed through a tiebreaker to notch the victory over Mathias Hambach and Filip Dzanko (9-8 (4)), while Eric Frueh and Juan Pablo Ramirez defeated Adam Reinhart and Kyle Johnson, 8-2.
Froment and Frueh competed in singles along with Ruben Weber, each tallying a win to add to their totals for the tournament. Froment easily handled DePaul's Sten Leusink to a score of 6-2, 6-3. Facing a battle against Jan-Willem Feilzer (DePaul), Frueh kept the match close, winning 7-5, 7-6 (4). Weber wrapped up the day in an extended game against Hambach defeating the Blue Demon in three (6-7, 6-4, 10-5).
Teams will close out the Gopher Invitational tomorrow. Singles begin the day's schedule at 8:30 a.m. with a second session beginning at 11:30 a.m. Doubles will take place at 10:30 a.m.
Summer Update: Levin and Sprinkel
Gophsports.com caught up with Justyn Levin and Jesse Sprinkel on what they have been doing this summer.
Summer Update: Corwin and Spec
Gophsports.com caught up with Felix Corwin and Matic Spec on what they have been doing this summer.
Summer Update: Alpeza and Krstanovic
Gophsports.com caught up with Marino Alpeza and Josip Krstanovic on what they have been doing this summer.


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- 21 & over
- Two drink minimum
- Special Event
Tempe, AZ
Comedy Central Certified
Share with your friends:
Whitney Cummings (Special Event)
Purchase Tickets
Show Details
- Ticket Price: $0.00
- Show Type: Stand Up
- Tags: Female, Edgy, Special Events
21 & over
Two drink minimum
Special Event
Preview Video
Performing Artists (Click on Artist for Reviews and Previews)
Whitney Cummings
Whitney Cummings is a Los Angeles based comedian, actor, writer and producer
Cummings is executive producer and, along with Michael Patrick King, co-creator of the Emmy nominated CBS comedy 2 Broke Girls, which was recently picked up for a fifth season. She also wrote, produced and starred in Whitney, which aired on NBC from 2011 to 2013. Cummings is also creating, writing, and starring in a new half-hour pilot ordered by HBO this year.
She appeared in the 2014 summer tour Oddball Comedy & Curiosity Festival, co-headlining with comics Sarah Silverman, Amy Schumer, Aziz Ansari, Louis C.K., and others.
Her second one-hour stand-up special, Whitney Cummings: I Love You, debuted on Comedy Central in June 2014 and she is shooting a third hour for HBO this August set to air in 2016
Cummings appeared regularly on E!'s, Chelsea Lately, as well as Comedy Central's Roast series. Her first one-hour stand up special, Money Shot, premiered on Comedy Central in August 2010 and was nominated for an American Comedy Award later that year.
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- Sun 8.28.16 - 7:00 PM Mark Viera Buy Tickets
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Welcome to Fraser Suites Glasgow, Scotland
Located within the prestigious Merchant City, Fraser Suites Glasgow is set in a beautifully-renovated 1850s Victorian building in a cultural quarter abound with museums and art galleries.
Home to a number of luxurious developments, the commercial and residential district is well served by restaurants, cafes, bars, boutiques and some of Glasgow's most upmarket stores.
Elegantly designed with a timeless appeal, Fraser Suites Glasgow offers 98 Gold-Standard luxury and sophisticated residences comprising studio, one- and two-bedroom residences and an Executive Floor, all well-equipped with modern conveniences. Whether it is for the interior furnishings, the facilities and amenities available or the convenient location, Fraser Suites Glasgow is the ideal choice for the discerning traveller, whether business or leisure, for long or short term stay.Close
Enrol to Fraser World and start saving!
- 5% off the Best Flexible Rate
- Free nights and Members Exclusive Offers
- Free WiFi


text:
- Report: #140657
Report - Rebuttal - Arbitrate
Complaint Review: JCPenney Salon
JCPenney SalonFashion Square Mall Saginaw, Michigan U.S.A.
JCPenney Salon at Fashion Square ripoff Unprofessional, nUndertalented, Overpriced, Closed-eared, Stylists Saginaw Michigan
*Consumer Comment: Don't fault ALL JCPenney Salons
*UPDATE Employee: FYI
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I was so startled, I just sat there staring at what she had done. My reaction apparently let her know it wasn't even close to what I had expected. She told me she made a few changes because SHE thought it would look better HER way. It couldn't be fixed... not enough left to fix.
I went from shoulder length hair to hair so short I can't even get a small curling iron to grab enough hair to curl. After half an hour of pulling, tugging, moussing, spraying, blow-drying and scrunching she finally gave up and stated it would grow back in a few months.
I won't go into how angry I was at the attitude of this stylist, and the Managers only added to my frustrations... They would have justified her scalping me bald.
Well, Ladies, reputation is everything and word of mouth holds alot of weight. As a business woman dealing with so many people in the community on a daily basis, I won't be giving JCPenney's Salon any cudos or compliments on their talents. CONSUMER BEWARE.
Birch Run, Michigan
This report was posted on Ripoff Report on 04/27/2005 04:09 PM and is a permanent record located here: http://www.ripoffreport.com/r/JCPenney-Salon/Saginaw-Michigan/JCPenney-Salon-at-Fashion-Square-ripoff-Unprofessional-nUndertalented-Overpriced-Closed-140657. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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#1 Consumer Comment
Don't fault ALL JCPenney Salons
AUTHOR: Jl - (U.S.A.)
SUBMITTED: Saturday, September 23, 2006POSTED: Saturday, September 23, 2006
Don't knock ALL JCPenney Salons! I personally go to the one at Briarwood Mall in Ann Arbor. After being treated ALL sort of WRONG, and getting crappy expensive highlights from OTHER mall salons. I sought out this JCPenney Salon and have been 100% thrilled. They treat me like gold there AND do a wonderful job. (I have long, highlighted hair and am VERY picky.)
Anyhow, if you can make it towards Ann Arbor, go there and ask for Nicole - she's an amazing stylist and a super nice person to boot. (I drive all the way from Howell to have her do my hair!)
Sorry about your hair. I've had several VERY bad experiences too. Thank goodness it will grow back! Consider writing a rip-off report about THAT particular stylist and her manager!! Or complain on a corporate level. I really don't think that is the kind of behavior that JCPenney Salons would in general approve of or defend!
Good Luck!
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#2 UPDATE Employee
AUTHOR: Debbie - (U.S.A.)
SUBMITTED: Thursday, September 14, 2006POSTED: Thursday, September 14, 2006
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utd fans always say it evens it self up when decisions like neville not getting an obvious 2nd yellow happen.i still think u are overall the best team in england so will end up winning the league. but i still think u should have a goal pocher upfront with a bit of pace.berb & rooney are good players but i still think all the play is ahea of the opposing defence. theres no fast striker with good movement making runs behind the defence which stretches them, pulls them out of position etc.rooney was poor attacking wise. his best moments were in his defensive side. so when u have rooney deep or back defending, that just leaves berb on his own upfront. & he isnt the most mobile or pacy foward.i would have thrown on hernandez a lot earlier to try & kill the game. 1-0 is always dodgy especially away to brum.u edged it & deserved to win...just. BUT then so do most teams who end up losing or drawing away to brum.i dont think gibson stamped his mark on the game enough.looks a bit lightweight for utd. but then again he is still developing. i can see him at a mid table prem team eventually.why not loan gibson instead to give him match time to develop?or maybe u should have loaned gibson instead of clevearly out to wigan? would clevearly done any better than gibson tonight?
I know this is unfair, but when I saw Gibson's name among the starters today, I had a bad feeling about this one.


text:
One Pot Recipes Needed Please!
Over a year ago
Next week, the Girl Guides I work with are doing some campfire cooking so I'm looking for easy, one-pot recipes that they can cook. Ideally I'd like the recipes to be vegan (because I am) but it's ok if they're just vegetarian because none of the Guides are vegan.
Thanks in advance 🙂
Please log in to reply.
Over a year ago
These are the recipes I made/adapted for them:
***One Pot/Pan Veggie Recipes – Perfect for campfires***
*Good Ol' Sausage and Beans*
(Serves 4)
8 veggie sausages, cut into chunks (I recommend Linda McCartney ones)
350g jar pasta sauce (any flavour but a tomato-y one would be best)
2 ripe tomatoes, quartered
410g can cannellini beans, drained (or whatever beans you prefer)
Tiny drop of oil
Can of mixed veg (optional)
1. Heat a large, wide frying pan over a high heat with just a little bit of oil (to stop the bangers sticking). When hot, add the sausages and cook for 5 minutes, stirring, until evenly browned.
2. Reduce the heat slightly and add the pasta sauce. Half-fill the jar with water, rinse out into the pan and simmer for 5 minutes.
3. Stir in the tomatoes and cannellini beans (and mixed veg, if using) and simmer for 3-4 minutes.
*Hash potatoes with eggs*
(Serves 4)
800g new potatoes, scrubbed clean
3 tbsp olive oil
6 rashers Quorn bacon, roughly snipped
2 ripe tomatoes, roughly chopped
4 spring onions, trimmed and finely chopped
4 large eggs
1. Chop the potatoes into small cubes. Heat 2 tablespoons of the oil in a large frying pan over a medium heat. Add the potatoes and cook for 20 minutes, stirring occasionally, until turning golden.
2. Add the bacon to the potatoes and cook, stirring occasionally, for 10 minutes. By now the potatoes should be golden and crisp at the edges.
3. Add the chopped tomatoes and mix well. Cook for a few minutes, until they begin to wilt and soften. Stir in the spring onions and season with freshly ground black pepper (if you like).
4. Push the potato hash mixture to the sides of the pan, making a big circle in the centre. Add half the remaining oil to the circle, then crack in 2 eggs and fry until the whites are set and the yolks hot.
5. Divide the hash between 4 plates, add the fried eggs to 2, then return the pan to the heat. Add the remaining oil to the pan and fry the remaining eggs the same way.
*Cheatin' Stew*
(Serves 4)
Two cans of vegetable soup (any type will do, if you're using a cheap soup then you might also want to add a can of mixed veg too, drain first)
One large can of new potatoes (chopped into smaller pieces)
One packet of vegetarian dumpling mix
Bread (optional)
1. Chuck the soup and chopped up potatoes (and mixed veg, if using) into the pan and start to slowly heat.
2. Make up the dumplings according to the instructions on the packet, divide the mixture up so that everyone gets at least two dumplings.
3. Put the dumplings into the pot with your 'stew' and simmer for around 20 minutes.
4. Serve with bread for dipping.
*Mega Easy Stir Fry*
(Serves 4)
Two packets of 'straight to wok' noodles
Two sachets of stir fry sauce (whatever flavour you like, just be careful as some may not be vegetarian)
One packet of firm tofu, or one packet of Quorn pieces
One ready-prepared pack of stir fry vegetables
Bit of vegetable oil
1. Heat up the oil in a frying pan/wok then stir fry the tofu/Quorn for 3-4 minutes.
2. Add the veggies and fry until full cooked.
3. Add the sauce and stir, cook for about a minute.
4. Add the noodles and stir fry for about 2-3 minutes.
*The Easiest Recipe OF ALL TIME!*
(serves as many as you like!)
Vegetarian burgers or sausages (enough so that everyone can have two)
Some veggie oil
Bread buns (either round or long ones, it depends if you're fitting a burger or a sausage into it!)
Onions (optional)
Sauces (optional but highly recommended!)
1. Heat up the oil in a frying pan.
2. Fry the burgers/sausages until cooked all the way through.
3. While they're cooking, if you're having fried onions then chop these up.
4. Once the burgers/sausages are ready, add to a bun and splosh on any sauce you like.
5. If you want onions, fry them then add them to your burger/sausage before you eat it!You must be logged in to reply to this topic.
Over a year ago
Supercool! Thanks for the recipes! 🙂You must be logged in to reply to this topic.
Over a year ago
Maybe try these…?
http://www.dirtygourmet.com/tag/vegan (adapted for kids)
http://www.veggieboards.com/forum/21-general-food-discussions/81659-camping-food.html (plus more threads listed on right side of page)You must be logged in to reply to this topic.
Over a year ago
Awesome! Thanks @alexblue 🙂You must be logged in to reply to this topic.


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Amazon.com Review
We may marvel at the process of an egg becoming an adult, but we accept it as an everyday fact. It is merely then a lack of imagination to fail to grasp how changes in this process that assimilated over long periods of time, far longer than the span of human experience, shape life's diversity."The book's second half is where Carroll really gets at the meat of evo devo, explaining how regulatory genes control such mysteries as individual and population changes in butterfly's spots, jaguar fur, and hominid skulls. Evo devo is one of the hottest areas of study in 21st-century biology, and Carroll's outline of the field is a great place to start understanding it. --Therese Littleton --This text refers to an out of print or unavailable edition of this title.
From Publishers Weekly
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