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Question: In an AP AOL sports poll Associated Press December 18 2005
In an AP-AOL sports poll (Associated Press, December 18, 2005), 272 of 394 randomly selected baseball fans stated that they thought the designated hitter rule should either be expanded to both baseball leagues or eliminated. Based on the given information, is there sufficient evidence to conclude that a majority of baseball fans feel this way?
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Answer to relevant QuestionsThe article "Americans Seek Spiritual Guidance on Web" (San Luis Obispo Tribune, October 12, 2002) reported that 68% of the general population belongs to a religious community. In a survey on Internet use, 84% of ...The article "Wait Times on Rise to See Doctor" (USA Today, June 4, 2009) gave the accompanying data on average wait times in days to get an appointment with a medical specialist in 15 U.S. cities. Construct a boxplot of ...Researchers at the University of Washington and Harvard University analyzed records of breast cancer screening and diagnostic evaluations ("Mammogram Cancer Scares More Frequent than Thought," USA Today, April 16, 1998). ...For the following pairs, indicate which do not comply with the rules for setting up hypotheses, and explain why: In a survey conducted by CareerBuilder.com, employers were asked if they had ever sent an employee home because they were dressed inappropriately (June 17, 2008, www.careerbuilder.com). A total of 2765 employers responded to ...
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text: The caves in Mark of the Assassin are simply incredible, the way Bioware was about to take a lone art guy from either the Mass Effect 3 or The Old Republic team and add a few more bushes, mushrooms, and broken 2x4s into the environment. Obviously sarcasm, Dragon Age 2 was a great disappointment in terms of the copy / paste method of art design, I actually enjoyed the story quite a bit and would like to see Hawke, Varric, Anders and perhaps even Nathanial return along with the Warden and Alistair (if they survived.)the first game as duel main characters when the third title inevitably comes out. As long as Mass Effect 3 delivers the way Mass Effect 2 did, all the lazy half-assed work they did for Dragon Age 2 will be forgiven in my opinion.

subset: commoncrawl


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Manti Te'o participates in 1st NFL rookie camp
Credit: The Associated Press
SAN DIEGO — Manti Te'o practiced for the first time with the San Diego Chargers on Friday determined to push the infamous girlfriend hoax and his lackluster national championship play into the past.
"I'm here to play football," the Chargers' second-round draft pick said on the opening of the rookie minicamp. "I'm not focusing on what is going on on the outside. I'm worried about what we're doing here in San Diego and I'm looking forward to when the veterans come in on Monday."
|The article you requested is no longer available on BostonHerald.com.


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She has the body of a goddess and eyes that can seduce the strongest man. With her you wouldn't know whether to moan out of want, or scream out of fear. Her poor victims don't suspect a thing, she betrays no emotions. How can you find the instinct to sense danger when her eyes call you and will you to submit to her every wanting? She's dangerous. The worst part is...I wouldn't love her any other way.
hugskissesx2 Apr 01, 2012
I love it! The writing has a few funny lines in it and its different from what I've read on here. Off to Chapter 2 ♥
JamezMichael Mar 31, 2012
Alright so after reading this I have a few suggestiong, try writing your story in Microsoft Word so you get the nice formating. You use a great amount of detail and your writing flow is amazing!
Mariah_EJ Mar 31, 2012
Lol,Kick my out of your house and I'll go to someone else's. Thats funny.
kissesNhugs4u Jan 07, 2012
I really like what is going on here! There is a writing style you have that makes this story come alive! I like what is happening to this story. I can't see why it is rated R. It doesn't seem to be that why. I love it so far though and its only the First Chap. *now off to chapter 2 <3 *
staceyy97 Jul 10, 2011
Love the plot, characters and your style of writing! This is really good!! :D *Voted*
Damonfan101 Jun 14, 2011
I love this story! very well written, barely any grammar mistakes, the story caught my attention, loved it! update soon ! :D


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When i grew up in NYC my gymnasium membership was $70 for each thirty. That works out to $840 put in for every calendar year or so. But due to the fact I was also purchasing my wife's health club membership that actually labored in order to $1680 a yr! We experienced memberships there to get a couple of years to ensure means I spent in excess of $3000 on gymnasium expenses in the course of that point. Which would not even think about all of that point time period we invested receiving return and forth the conditioning. As you have likely listened to before, time is hard acquired money.
In ought to not fashion, you switch all those resistance trainers with very simple objects because rubber bands. You will get them for more cost effective expenses and become practically precisely the same kind of exercise session jointly.
The worth training just one particular motive customers are hesitant to start out any new workout ideas. Certainly one of the most beneficial methods maintain funds find yourself becoming to comparison shop. No matter whether comparing rates for fitness center memberships, nutritious food stuff or residence gym training machines, being aware of especially, what is out there will allow you make clever conclusions. Look at weekly commercials either on line or maybe a Tallahassee Democrat. For healthy foodstuff, Publix places a different advertisement in addition to in stores each and every Thursday, and there's normally make inexpensive. Keep an inventory of what normally fees much more where, and you also will most likely be inside a extremely truly dwell a much healthier way of life bodily and fiscally.
I was so horrified by my photo which i rushed suitable into a close by Chinese retailer and requested them if they'd any natural tea which supports me lose an related to fat as soon as possible. I bought a cup and quickly started off ingesting finding this finished. In 2 weeks, I did not eliminate any fat, in its place I begun obtaining nervousness and twitching around my human body.
The barbell consists to the chrome vanadium bar, this agreement weights could be connected at both give up. There are three commonly noticed barbells. These usually be conventional bar, the Olympic bar and the EZ lawyer bar. The typical bar is five to seven feet in size and weighs about 20 undesired fat. It truly is best for operating smaller muscle mass mass this kind of given that the biceps and triceps.
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Just look around-the World wide web is relating to possibilities results get the least high priced dwelling health club work out tools. One does some investigation below, as well as you certainly choose cheap alternate options towards the pricey gizmos that carry the title of total human body exercise gear. Make your selection designed from purpose, not the expense of the unit that a person stumbled on or found within your regional exercising reception venue.


text: This Atlantic Jaxx compilation was assembled by Felix from Basement Jaxx and Russ Jones of the Future World Funk series. There are 15 cuts here on Gypsy Beats and Balkan Bangers, either in original version form or remixed. It's the originals that are the real attraction, though. "Balkan Hot Step" by N.O.H.A. is the biggest track; discovered by Gilles Peterson, it's an aboveground club hit. . . . .


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Gerald Templer
Quotable: Paul Boothroyd on messaging during the Malayan insurgency
Thursday, April 6th 2017
Information operations in Malaya were a particularly effective tool that led to the surrender of many insurgents while simultaneously bringing the Chinese population of Malaya onto the side of the government. However, this was the result of years of trial and error during which the British gradually adapted their message to meet the demands of the conflict.
Read More
Quotable: David Ucko on Totalitarian "Hearts and Minds" Campaigns
Monday, May 23rd 2016
Totalitarian states have often launched "hearts and minds" campaigns against restive or occupied populations. David Ucko of the National Defense University examined several examples – the early Soviet Union, Chechnya, China's policies toward the Uighurs, the Soviet occupation of Afghanistan, and others – in a suggestive article, "Cruel to be Kind: Authoritarian Counterinsurgency and the Winning of Hearts and Minds," on the lawfare.com website on May 22, 2016.Read More


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Teaching and Learning for the 21st century: Educational goals, policies, and curricula will be available in Chinese in September 2016.
Executive Summary of our book
Teaching and Learning for the 21st Century: Educational goals, policies, and curricula in Chinese
Download from link below:
Executive Summary in Chinese
Creative China
Published in May 2014 in China, Jiang Xueqin's memoir Creative China examines what is possible within Chinese education reform, and how to implement creativity in the classroom. In 2008, just as more and more Chinese high school students were opting for American colleges, Mr. Jiang built and managed a study abroad program at Shenzhen Middle School, south China's top public school. Students themselves took responsibility for the program, and in the process built the first coffeehouse and the first daily newspaper in a Chinese high school. In 2010, Mr. Jiang built and managed the International Division at Peking University High School, a program to educate the next generation of China's creative class by teaching them global citizenship and social responsibility. Mr. Jiang's central argument is that creativity is both possible and necessary in the Chinese classroom, and once educators take that leap of faith then the limitless potential of their students will be finally unleashed.


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Manchester born blues legend Victor Brox is probably one of the most underrated champions of the British Blues scene and its unsung hero. This may well have been because he has refused to be pigeon-holed into any single category and has produced an eclectic style which often defied analysis. What cannot be disputed is his excellent singing voice, musical virtuosity and total eccentricity. He was described by Jimi Hendrix and Tina Turner as their favourite white blues singer. Victor will be joined on stage by his daughter and M&P resident musician Kyla Brox.
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mediaFORGE offers solutions to socialize and monetize branded, immersive and portable widgets that leverage existing online advertising inventory.
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Everyone would love to have pearly whites, and having yellowish teeth doesn't help you flash that bright beaming smile with great confidence!
Fortunately, you can whiten your teeth without having to spend a ton of money using natural ingredients. The best thing is you can do it right at the comfort of your own home!
Boost your self-esteem and flash that beaming white smile with this simple remedy that produces instant results! You don't need to wait days before you see your teeth whiten up, so take a look at this natural home remedy and try it out now!
Make your own teeth whitening paste using these two key ingredients: * 8 tsp. baking soda
* 8 tsp. virgin coconut oilCombine the ingredients well and use it along with a toothpaste to brush your teeth. You will be amazed at the results right after you rinse!


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While everyone else is distracted by the Witcher 3: Wild Hunt, now is as good a time as ever to go on the hunt for some game deals.
Luckily, there's some great deals on offer this week, particularly for fans of action games on Steam and the consoles, while Humble Bundle serves up a host of point-and-click adventure goodness. So if you manage to tear yourself away from Geralt's third outing, or if it didn't take your fancy in the first place, there's plenty of alternatives to sink your teeth into for the Bank Holiday weekend.
Steam has three potential options this week, with Dying Light opening at $44.99, the Batman Weekend Deal with many Batman games at around 75% off, and the Shadowrun PC titles, including Returns, Dragonfall Director's Cut, and Hong Kong.
gog.com has no major on-going specials this week.
Indie Game Stand has Eschalon: Book I as its pay-what-you-want deal, a "classic role-playing game experience that will take you across massive outdoor environments and deep into sprawling dungeons as you seek to uncover the mystery of who – or what – you are."
Bundle Stars
Bundle Stars has, as always, a very impressive list of bundles.
The full list includes the Barbaric bundle ($3.49 for 10 games), the Victory Mega bundle ($2.99 for 14 games), the Deep Space bundle ($2.99 for 10 games), the Victoria Complete bundle ($4.99 for 2 games + 9 DLC), the Tex Murphy bundle ($2.49 for 5 games), the GRID 2 Complete bundle ($14.99 for GRID 2 + 11 DLC), the LEGO Super Heroes bundle ($14.99 for 5 games), the AI War Complete bundle (AI War: Fleet command + 10 DLC), the Guardians of Middle Earth bundle ($4.99 for Guardians of Middle Earth + 7 DLC), the Reboot 4.0 bundle ($2.99 for 6 games), the Reboot 2.0 bundle ($2.99 for 6 games), the Hacker (Reloaded) bundle ($2.99 for 13 games.), the RPG Champions bundle ($4.99 for 6 games), the Reboot 7.0 bundle ($2.99 for 6 games and DLC), the Reboot 3.0 bundle ($2.99 for 6 games), and the Blaze of Glory bundle ($3.49 for 6 games).
Having GRID in the Barbaric bundle and not in the GRID 2 Complete bundle is an interesting choice, but both are excellent games. In particular, I would likely recommend going with the Barbaric first. That said, the Deep Space bundle looks the most appealing, with Space Pirates and Zombies being the premier title and well worth the asking cost alone. Universe Sandbox is also an interesting tool for exploration and intrigue, but not precisely what people would expect on first hearing that it's a game.
Indie Gala
Indie Gala has come with week with its usual assortment of Monday, Wednesday, and Friday bundles, in addition to a fourth. This week's Monday bundle ($2.49 for 5 games.) is particularly haywire, with Leisure Suit Larry in the land of Lounge Lizards next to cute indie platformer series Neko Chan Hero. This week's Hump Day bundle ($3.19 for 12 games.) have a space and sky theme, with Starlaxis Rise of the Light Hunters and Dogfighter.
The Friday bundle ($3.19 for 12 games.) this week has indie standouts Retro/Grade and Pixel Piracy in the mix. The fourth pack is the Bedlam bundle ($2.89 for 10 games), including early access for first-person shooter Bedlam, and has a decided zombie tilt as a result.
The Friday bundle speaks to me the most this week, with the aforementioned Retro/Grade and Pixel Piracy in the mix, and Magnetic by Nature has the sort of art style that pushes all the right buttons.
Humble Bundle
The Humble Paradox Bundle is still reigning from last week. It's hard to do much better than Paradox for PC strategy games. Crusader Kings II is no stranger to the Weekly Gaming Deals, and is one of the best grand strategy games money can buy. With Victoria II, Europa Universalis IV and Hearts of Iron III also included depending on how much you pay, it'll be a long time before you'll need to buy another strategy title again.
As with last week, War of the Roses: Kingmaker, Magicka + Other Side of the Coin and Horror Prop item packs, Knights of Pen and Paper +1 Edition, Victoria II, Magicka Wizard Wars Platypus Wizard Robe and a "Helping Heart" Paradox Forum Icon.
Paying above the current average of $5.59 will also unlock Hearts of Iron III, Impire, Crusader Kings II (with the Sons of Abraham expansion), added new this week Ship Simulator Extremes, Teleglitch: Die More Edition, Sengoku and a soundtrack. Stretching up to $15, will also net you Europa Universalis IV and the Conquest of Paradise expansion.
The weekly bundle is going on an adventure this week, with the Humble Weekly Bundle Adventures! 2 and holds Secret Files: Tunguska, Stacking, Syberia and The Novelist with digital extras. Going above the average, currently $4.09, and will add The Night of the Rabbit Premium Edition, Broken Sword 5 – The Serpent's Curse, and Always Sometimes Monsters. Bringing the value higher to $8 or more adds The Raven – Legacy of the Master Thief Digital Deluxe Edition and Blackwell Epiphany.
Rounding off the list is the Humble Artifex Mundi Mobile bundle, with an average of $5.96. Pay what you want for Deadly Puzzles, Time Mysteries 1 and Clockwork Tales. Above the average will include Demon Hunter, Grim Legends, Time Mysteries 2 and Time Mysteries 3. For beating $9, the bundle will add Grim Legends 2 and Enigmatis 2.
PlayStation Store
The Playstation Store is currently running an Extended Play sale, with several excellent choices. Some of the standouts include Alien: Isolation for PS3 ($40.00) and PS4 ($45.00), which we reviewed very well with a 9 in our Alien: Isolation review, and Battlefield 4 Premium Edition for $25.00 on PS3 and PS4.
Xbox Live
Microsoft's Deals With Gold has no major spotlight this week, but includes Dragon Age: Inquisition for $29.99, and Dragon Ball Xenoverse for $49.99 for the Xbox One. Games with Gold this week has Pool Nation FX, Castle Storm Definitive Edition, and F1 2013.
Nintendo Network
Nintendo's Offers page continues to state the Mario vs Donkey Kong Tipping Stars cross-buy program. The Capcom Spring Sale is likewise still ongoing for the next week or so, ending on the 28th.
My personal highlights include Persona Q: Shadow of the Labyrinth ($39.99, 3DS), Trine and Trine II ($9.99 each, WiiU), and Duck Tales Remastered ($6.75, WiiU).
That's it for this week! As always, leave your comments below, and let us know if we've missed anything.


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About Us
We are Neuron Syndicate, a Santa Monica Based Ad agency in Santa Monica. you can check us out at
Scott Gentle for Job #54458 Book Assassin Killer Great fun to work with Ryan and his crew, and even though it took a while to finally be released, the end result was absolutely killer (a lot like the character I voiced!)....thanks guys!Aug 7, 2013


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Rocket 88 (Original Version) - Ike Turner/Jackie Brenston MP3
Widely acknowledged as the first "rock and roll" song.
Rocket "88" - Jackie Brenston & His Delta Cats MP3
I don't want to create a controversy but when some say "this is the first title of the Rock and Roll music history" listen "When the Levee Break" by Kansas Joe ...
JACKIE BRENSTON & HIS DELTA CATS: "rocket 88", 1951 MP3
Los "Delta Cats" eran en realidad los "Kings of Rhythm" de Ike Turner. Era muy habitual grabar con un nombre diferente si la ocasión lo requería. Es un sencillo ...
Rocket 88 - Bill Haley and the Saddlemen MP3
Correction: This was recorded June 14:th 1951 for Holiday Records. Jackie Brenston did the original a few months earlier,but some people say this version is the ...
rocket 88 "Jackie Brenston & His Delta Cats" MP3
Considered by many to be the very first Rock n Roll song.
ike turner rocket 88 (lawrence fishburne) MP3
scene from the movie whats love got to do with it tina turner story.
How to play Rocket 88 by Jackie Brenston & His Delta Cats on guitar by Mike Gross MP3
"Rocket 88" is a rhythm and blues song that was first recorded in Memphis, Tennessee, on March 3 or 5, 1951. The recording was credited to Jackie Brenston ...
James Cotton - Rocket 88 MP3
James Cotton - Rocket 88 check: http://www.jamescottonsuperharp.com/
1953 Oldsmobile Rocket 88 Start Up, Exhaust, and In Depth Tour MP3
In this video I give a full in depth tour of the 1953 Oldsmobile Rocket 88, 2 speed auto hydromatic transmission, power brake, and power steering with a 303 ...
Jackie Brenston & His Delta Cats - Rocket 88 MP3
Jackie Brenston was an American R&B singer and saxophonist, who recorded, with Ike Turner's band, the first version of the pioneering rock and roll song ...
Dan Aykroyd Rocket 88 MP3
on Letterman.
Jackie Brenston/Ike Turner - Rocket 88 ( First Rock N Roll Song Ever Recorded ) MP3
https://www.facebook.com/groups/136097376533737/?fref=ts Recorded at SUN Records or if you would say Memphis Recording servis. Recorded on March 5, ...
Rolling Stones Rocket 88 feat. Charlie Watts and Ian Stewart MP3
Charlie Watts and Ian "Stu" Stewart at the North Sea Jazz Festival The Hague, Holland (The Netherlands) July 14, 1979 St. Louis Blues.
Bill Haley - Rocket 88.wmv MP3
Rocket 88 Ike Turner and Jackie Brenston with Lyrics MP3
Rocket 88 Ike Turner and Jackie Brenston with Lyrics.
Boogie Woogie : Mike Sanchez Band - "Rocket 88" MP3
Movie recorded at a concert in Compiegne, France in February 2010. Mike Sanchez is a Rhythm and Blues singer, pianist and songwriter of Spanish-English ...
1995 Oldsmobile Eighty Eight Royale LSS SS Supercharged Olds Rocket 88 MP3
This is a Very Rare car Not only is this 1995 Oldsmobile Eighty Eight Royale LSS a 62000 Original mile car it is a 1 Owner car and has been taken care of like no ...
Rocket 88 by Rufus Thomas MP3
In memory of my Uncle Donald Parks and his band Donald and the Rockers. A regional rock band that recorded several 45s. If anyone has a copy please ...
TAFC Oldsmobile Rocket 88 1949 first look MP3
Taking delivery of my new baby.
Jackie Brenston and his Delta Cats: "Rocket 88" (Introduction) MP3
A video listening guide to accompany the textbook, What's That Sound? An Introduction to Rock and Its History (W.W. Norton), presented by John Covach.
Jackie Brenston - Rocket 88 with lyrics MP3
First rock and roll song.
1950 Oldsmobile Rocket 88 Futuramic "Hot Rod" MP3
1950 Oldsmobile 88 Rocket Futuramic "Hot Rod" Awesome Olds Rocket 88 Futuramic is built Right, from the Engine to the Paint not a Detail missed.
Clutch Earth Rocker: Rocket 88 MP3
Clutch front man, Neil Fallon, talks about early rock n' roll influences on the band's upcoming record, Earth Rocker. Producer/Director: Agent Ogden.
132198 / 1957 Oldsmobile: Golden Rocket 88 MP3
For more information on this vehicle visit http://tinyurl.com/blcwa26 Don't be fooled by the large-by-huge chrome wheels it's wearing today, this particular '57 ...
Rocket 88 - ENERGI! (Live Sh*t! Official) MP3
We are the New Wave of Rock! Check out our single "Energi!" available for free download https://soundcloud.com/rocket88radio/energi Rocket 88 are: Pradipta ...
"Rocket 88" Arlen Roth w/ Johnny Winter MP3
"Rocket 88" (originally written as Rocket "88") is a rhythm and blues song that was first recorded in Memphis, Tennessee, on March 3 or 5, 1951 (accounts differ).
Rocket 88 - Tim Timebomb and Friends MP3
The original Rocket 88 was produced by Sam Phillips (Sun Records) for Chess Records in 1951. Jackie Brentson and his Delta Cats had a number one on the ...
Mitch Woods - Rocket 88 MP3
uploaded in HD at http://www.TunesToTube.com.
Regular Car Reviews: 1956 Oldsmobile Super 88 MP3
The 1956 Oldsmobile Super 88 is repressed sexuality.


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Culturelist host LeToya Luckett has cropped and colored her tresses for a sexy new shoot with Bleu magazine and it's a good look!
The "Bombshell" shoot, captured by Danielle Kwateng, features the 32-year-old talent sporting Tom Ford heels and a striped button down as she serves up a seductive stare. Celebrity makeup artist AJ Crimson and hairstylist Nikki Wright assisted with the spread.
While Luckett has shot down any and all reports surrounding her involvement with the rumored Love & Hip Hop Houston, she can be seen on the third season of VH1's Single Ladies alongside former Culturelist guest LisaRaye McCoy, Charity Shea and Denise Vasi.
What say you? Are you feeling LeToya's new look?
(Photo: Letoya Luckett via Instagram)


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My dog Rhoda and I met Molly and her owner in a park across the street from our apartment in Jersey City, NJ. It was love at first sight. Their eyes locked; they ran across the tennis court and collided in the middle with a top-speed body slam, teeth clacking as they chewed on each other.
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Soon, we got a key to Molly's house. While her owners were at work, Rhoda and I took Molly to the park, then our apartment, where they'd wrestle while I worked. We'd drop Molly off a few hours later, and Rhoda would pass out for the rest of the day.
More from Prevention.com: Is Your Pet Too Pudgy?
I had no idea how lucky I was. Last summer, I moved to Memphis and quickly realized: It's impossible for me to tire Rhoda out by myself, and finding a new best dog friend isn't easy. The nearest dog park is 20 minutes away--and Rhoda just sniffs the grass instead of playing with other dogs.
"It seems crazy," I told my boyfriend, "but I think she misses Molly."
I wasn't crazy. "Dogs need friends just like people do," says Pam Reid, PhD, vice president of the ASPCA's Animal Behavior Center. But dog parks aren't the best place to find them. "It's like going to a party where there's a bunch of strangers," Reid says. "Not everybody's going to be okay jumping right in." And getting comfortable isn't simply about familiarity: Dogs have different personalities, and some personalities just don't click.
Occasionally we'd meet a dog Rhoda clicked with--then we'd never see it again. Soon I found myself on Dogster, a rapidly growing canine social networking site, where I created what looked like an online dating profile for Rhoda ("Desperately Seeking Playmates"). Suddenly, I was inundated with e-mails from pet owners writing in the first person as their dogs, often in baby voices. I found those owners painful, and Rhoda clearly felt the same about their dogs. So I started looking for like-minded people who I figured must have like-minded dogs.
That's when I turned to Facebook, the social networking site for humans. I searched for people my age in Memphis and then checked their profiles to see if they--like me--had Facebook pages for their dogs. I e-mailed a funny guy with a dog named Abbey: This may sound weird, but I just moved to town and. Soon, Rhoda and Abbey were unconscious from exhaustion while we humans drank wine and laughed.
I found Slippers in a coffee shop, where I overheard a woman talking about how fast her dog could run. I found Hazel during orientation for my new teaching job. I'd planted myself next to a woman who looked like she could be a friend and then casually mentioned dogs to see how she'd respond. Bingo. Now we hike together--two women, two dogs. Rhoda and I couldn't be happier.
The old dogs-look-like-their-owners saying is bogus: I'm brunette, Rhoda's blonde. She has fur on her face, and, well, I wax. Still, we're the same: We like the same people and the same dogs. We need friends, and thanks to those friends, we now like our new city too.
How to make dog friends
Register online
On dogster.com, set up a profile for your pet, searchable by city. Do the same on facebook.com using the Dogbook application. Or, join a local, interest-based group on Dogster.
Try doggie day care
Invest in a few half-days at one that offers playtime, where they let dogs mingle. (Prices range from $15 to $30 per day.) Ask the staff which dogs yours plays with and then contact the owners.
Educate to recreate
Sign up for group obedience classes to meet dogs that are at a similar developmental level as yours.
Rebecca Skloot was a veterinary technician for 10 years before becoming a science writer. Her work appears in the New York Times Magazine and others.Tags: petsCopyright © 2017 Rodale Inc.
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When CHESTER CHEETAH puts his name on a snack, you can count on a bold and cheesy flavor like you've never tasted. CHESTER'S snacks are made with a special blend of real cheese seasoning to give each bite the perfect pop and zing.
Enriched Corn Meal (Corn Meal, Ferrous Sulfate, Niacin, Thiamin Mononitrate, Riboflavin, Folic Acid, Vegetable Oil Corn, Canola, and/or Sunflower), Cheese Seasoning (Whey, Cheddar Cheese (Milk, Cheese Cultures, Salt, Enzymes), Maltodextrin (Made from Corn), Canola Oil, Salt, Whey Protein Concentrate, Natural Flavors, Lactic Acid, Yeast Extract, Artificial Color (Including Yellow 6), Citric Acid), Salt.
Always refer to the actual package for the most accurate information


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Author | exchange4media News Service | Friday, Sep 11,2015 8:19 AM
The inaugural edition of the Maddies Awards 2015 saw some of the best work in the mobile domain being recognised. In its inaugural edition, Mindshare won 'Agency of the Year', PepsiCo named 'Mobile Marketer of the Year' at the Maddies Awards. exchange4media spoke to some of the winners of the Maddies Awards 2015.
Kshitij Karnad, AVP – Digital & Mobility Services, PHD spoke on winning 2 Golds, 2 Silvers and 1 Bronze said, "Awards are a great barometer for the kind of hard work that a team puts in. And Maddies from exchange4media is a great platform to be winning on, so we are really excited. Thanks to the client, the jury and for exchange4media for choosing us as the winners in the categories we won in. Mobile is increasingly becoming the main means of engaging with consumers and it is no more an ancillary medium like it was sometime back. So it is great to be winning in these categories and great to be connecting with consumers."
Neeraj Karambelkar, AVP Marketing, Fame Digital winning the Gold award for the #Fame Anthem said, "I would like to thank exchange4media and the jury for giving us this honour and this recognition. This anthem is core to all of us and the sole of the brand. We started our communication and marketing activity with this anthem and it feels great to be recognised across the different forums and platforms and award ceremonies for creating a piece of communication."
Pancham Endlaw, Head – Advertising, South Asia, Opera Mediaworks won a Silver award for their work on Askmebazaar said, "It is great to be recognised for our efforts. We have kind of burnt the midnight oil for our client Askmebazaar.com for working on their sales strategy and for getting in sales. This is actually an acknowledgement of the effort we put in and I would sincerely like to thank the jury of the Maddies for choosing us for this honour. I think Maddies is a great platform to recognise the effort and talent that we are growing here in India. Looking at all the winners and the due diligence which has gone in to choose the winners, I think it is a great product."
Programming HeadRadio Mango


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Anzo USA Tail Light Set 211032 94-03 S10/94-04 SONOMA TAIL LIGHTS 3D STYLE CHROME
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Botnek Tour dates 2017
Botnek tickets are on sale right now on ConcertPass. ConcertPass is your number one destination for all Botnek concerts tickets as well as concert dates and extensive tour information. On ConcertPass you'll find Botnek tickets at great prices across an excellent range of seating options. We'll let you pick your seats from our interactive maps so you can find the seats that are right for you. All Botnek concerts tickets come with our ticket integrity guarantee, with all tickets guaranteed or your money back. You'll find tickets for thousands of concerts and events on ConcertPass, so please feel free to browse around. Be a part of the action and witness great some performances right now, buy your tickets for Botnek today, so you don't miss out.
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Well-known member
Is it possible to have a create thread overlay? I am trying to do this at the moment, but hitting a few issues, the main being the "Upload a file" button causes the existing overlay to close, is there a way to prevent it from doing this, so it just opens above it?
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HOBO INTERNATIONAL Savoy Clutch
The rich amethyst color is perfect for autumn. A simple clutch like this will get you through the season with a perfect pop of color. It's roomy too, for all your credit cards-and your passport. You never know where you might go with this in your hand. Pair it with that sleek gray cashmere sweater dress you love and a tall pair of boots.
Perfect size and great quality.Tags: accessories, bags, women, clutchesAdded 7 Years Ago from Endless
this one is the best. I looks super richTags: accessories, bags, vegan, clutches, faux, cruelty free, clutch bagsAdded 8 Years Ago from Endless
This bag can be folded or carried upright ,it converts to a small tote.Tags: patent leather, black, clutches, JaldiAdded 9 Years Ago from Endless


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If you or your partner snores, it is important for you to know about the adjustable self-fit TheraSnore, the worlds leading oral appliance and one of the most effective treatments for snoring and sleep apnoea.
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15th International Symposium on Spatial and Temporal Databases (SSTD 2017)
Register here.
Washington, DC - August 21-23, 2017
The 2017 International Symposium on Spatial and Temporal Databases (SSTD 2017) is the 15th event of a series of biannual symposia that discuss new and exciting research in spatial, temporal and spatio-temporal data management and related technologies with the goal to set future research directions. SSTD symposia primarily focus on original results in theoretical foundations, design, implementation, and applications of spatial and temporal database technology. SSTD also welcomes experience reports from application specialists and the commercial community that describe lessons learned in the development, operation, and maintenance of actual systems in practical and innovative applications. The goal is to exchange research ideas and results across academia, industry and government from diverse geographies, and career stages.
SSTD 2017 will be held in the Washington, D.C. area at the George Mason University campus in Arlington, Virginia, USA.


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Directions to Greenway Spirit & Word Fellowship
Coming South on I81
Exit 310 Kernstown and turn left
Continue straight through lights. This is Tasker Road (Rt 642)
You will travel roughly two or three miles on Tasker Road. Go through one more light.
Drive a very short distance and you will see church is on left.
Coming North on I81
Exit 307
Turn right onto Fairfax Pike
At fourth stop light turn left onto Warrior Drive
At the next stop light on Tasker Road turn left. Church is on the right.
Coming from 522 midway between Front Royal and Winchester
Turn onto Tasker Road at the stoplight at Walmart
Stay on Tasker until you come to 1275. Located right beyond the light at CVS
Coming from Route 37
At the end of Route 37, turn left onto Tasker Road
Follow through one stop light to 1275 Tasker
Country Inn & Suites
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Spouses of military service members serving on active duty are eligible for the same scholarship as the military service member, regardless of whether or not the military service member is a student at Strayer University.
Military Spouses must supply the service member's LES at the time of registration for the scholarship to be posted; it will only need to be provided for the first term of enrollment.
Military spouse scholarships is a program which offers a complete tuition reimbursement opportunity for undergraduates, while graduate students will be responsible for paying a portion of the tuition as an out-of-pocket expense.
Scholarships will be applied to all active duty personnel that supply a Leave and Earnings Statement to Strayer University. Please contact your Admissions Officer for additional details and information about military spouse scholarships.


text:
Citation Edit
General Accounting Office, Microcomputer Security: Audit Problems and Solutions, 1 J. of Accounting and EDP 49 (Winter 1986) (full-text).
Overview Edit
This article discusses the resolution of security problems involving the use of microcomputers in business by: (I) identifying audit problems which arise; and (2) presenting management countermeasures. Microcomputer use carries risks in three major areas: (1) physical security of hardware; (2) physical security of data and software; and (3) data integrity.
Physical security of hardware involves common-sense methods to prevent theft or damage. Various methods in use to secure data and software include: (1) password protection; (2) data encryption/decryption; (3) copy protection; (4) audit trails; and (5) security controls on the microcomputer-mainframe link.
Maintaining current, accurate, and complete data requires: (1) standard hardware and software configuration within an organization; (2) data and program backup; (3) testing and documentation of computer models and user-written programs; and (4) use of current data only. Auditors should make use of available programming tools, such as cross-reference, file recovery, disk explorations, sort/merge, and file dump. A partial list of hardware and software available for microcomputers is included.


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The ApcMin/+ mouse has a mutation in the Apc tumor suppressor gene and develops intestinal polyps, beginning at 4 wk of age. This mouse develops cachexia by 6 mo, characterized by significant loss of muscle and fat tissue. The purpose of the present study was to determine the role of circulating interleukin-6 (IL-6) and the polyp burden for the development of cachexia in ApcMin/+ mice. At 26 wk of age, mice exhibiting severe cachectic symptoms had a 61% decrease in gastrocnemius muscle weight, complete loss of epididymal fat, a 10-fold increase in circulating IL-6 levels, and an 89% increase in intestinal polyps compared with mildly cachectic animals. ApcMin/+/IL-6−/− mice did not lose gastrocnemius muscle mass or epididymal fat pad mass while overall polyp number decreased by 32% compared with ApcMin/+ mice. Plasmid-based IL-6 overexpression in ApcMin/+/IL-6−/− mice led to a decrease in gastrocnemius muscle mass and epididymal fat pad mass and increased intestinal polyp burden. IL-6 overexpression did not induce cachexia in non-tumor-bearing mice. These data demonstrate that IL-6 is necessary for the onset of adipose and skeletal muscle wasting in the ApcMin/+ mouse and that circulating IL-6 can regulate ApcMin/+ mouse tumor burden.
- cachexia
- colorectal cancer
- inflammation
- polyps
cachexia is characterized as an overall state of ill health, accompanied by a loss of lean body mass and fat mass, weakness, fatigue, anemia, metabolic abnormalities, inflammation, and impaired immune function, with or without anorexia (2–4, 24). This condition is associated with other life-threatening diseases, such as cancer and AIDS, and negatively affects life quality and survival (2, 26, 36). Almost 50% of all cancer patients experience progressive wasting of adipose tissue and/or skeletal muscle mass (37), predominantly during the terminal stages of disease. Cancer patients can lose up to 30% of their original body weight, and cachexia accounts for ∼20–33% of cancer deaths. In particular, gastrointestinal and lung cancer patients are extremely susceptible to cachexia (16, 31). The ApcMin/+ mouse is an established model of colorectal cancer and cachexia (28, 30). This mouse develops intestinal polyps as early as 4 wk of age and becomes cachectic between 3 and 6 mo of age. Use of ApcMin/+ mice to study cachexia has many advantages in that these mice have a polyp burden that mimics human colorectal cancer, chronic low levels of circulating interleukin-6 (IL-6), and lack of anorexia. However, the mechanisms inducing wasting in these mice are poorly understood.
One potential candidate for inducing cachexia is IL-6, a pleiotropic cytokine that modulates a variety of physiological responses and activates genes associated with cellular proliferation, differentiation, and apoptosis (20). Elevated circulating IL-6 levels have been associated with cachexia (21). Intraperitoneal IL-6 treatment (40), intracerebroventricular IL-6 injections in the lateral ventricle, IL-6 transgenic mice (38), and colon-26 tumor-bearing mice with elevated plasma IL-6 levels (45) all demonstrate an ∼25% decrease in gastrocnemius muscle weight. Blocking IL-6 through neutralization antibodies results in attenuation of IL-6-induced muscle wasting in rodents (14, 35, 39, 44). In contrast, some studies administering exogenous IL-6 to rodents fail to find an association between high circulating IL-6 levels and cachexia (12, 15, 33, 42, 43). The disparities between studies on IL-6 and cachexia point to indirect effects of IL-6 on skeletal muscle wasting during cancer. One such indirect mechanism may be IL-6-induced tumor growth. IL-6 is also a potent tumor growth factor (8, 13, 34), and the contribution of IL-6-induced tumor growth to cachexia has not been elucidated.
IL-6 elicits its effect by binding to a plasma membrane receptor complex that contains the common signal-transducing receptor chain glycoprotein 130 (9, 20, 23). Ligation of this receptor activates signal transducers and activators of transcription (STAT-3) (9, 11, 20), which is generally associated with cell growth, differentiation, development, and survival (6). Skeletal muscle and myotubes are sensitive to IL-6, and treatment with IL-6 results in phosphorylation of STAT-3 (1, 17, 19, 32, 41). Skeletal muscle STAT-3 is activated during atrophy (18, 22), but it is unknown whether muscle STAT-3 activation leads to cachexia.
The purpose of the present study was to determine the relationship between circulating IL-6 and polyp burden for the development of cachexia in ApcMin/+ mice. We hypothesized that increased circulating IL-6 would both increase the polyp burden and overall wasting in ApcMin/+ mice. In addition to wild-type and ApcMin/+ mice, ApcMin/+/IL-6−/− mice were developed to ablate IL-6. A plasmid-based in vivo electroporation system delivered into skeletal muscle was used to overexpress IL-6 in ApcMin/+ and ApcMin/+/IL-6−/− mice, as well as wild-type mice.
C57BL/6, ApcMin/+, and ApcMin/+/IL-6−/− mice were originally purchased from Jackson Laboratories (Bar Harbor, ME), and breeding was maintained at the University of South Carolina's animal resource facility as previously described (28). ApcMin/+ mice (n = 12) were housed individually in cages with voluntary activity wheels and killed at 26 wk of age (see activity protocol below). ApcMin/+/IL-6−/− mice were genotyped for the mutant Apc allele, IL-6, and neomycin resistance. The primer sequences for IL-6 were as follows: forward 5′-TTC CAT CCA GTT GCC TTC TTG G-3′ and reverse 5′-TTC TCA TTT CCA CGA TTT CCC AG-3′. The reverse primer sequence for neomycin resistance was as follows: 5′-CCG GAG AAC CTG CGT GCA ATC C-3′. ApcMin/+/IL-6−/− mice (n = 8), ApcMin/+ mice (n = 7), and C57BL/6 mice (n = 5) were killed at 26 wks of age to examine a cachectic time point. Another group of ApcMin/+/IL-6−/− mice (n = 6), ApcMin/+ mice (n = 6), and C57BL/6 mice (n = 5) were killed at 13 wk of age to examine a precachectic time point. To increase circulating IL-6 levels, 16-wk-old C57BL/6 [control (n = 10) and +IL-6 (n = 10)], ApcMin/+ [control (n = 8) and +IL-6 (n = 10)], and ApcMin/+/IL-6−/− [control (n = 8) and + IL-6 (n = 6)] mice were used for IL-6 overexpression experiments (see procedure below). The room was maintained on a 12:12-h light-dark cycle with the light period starting at 0700. Mice were provided standard rodent chow (Teklad Rodent Diet no. 8604; Harlan, Madison, WI) and water ad libitum. Body weights and food intake were measured weekly. All animal experimentation was approved by the University of South Carolina's Institutional Animal Care and Use Committee.
Voluntary wheel running activity.
ApcMin/+ mice (n = 12) were housed individually with 9.5-in.-diameter stainless steel activity wheels at 4 wk of age (Mini Mitter, Bend, OR). Running activity was monitored from 4 to 26 wk of age. Bicycle computers (Specialized, Morgan Hill, CA) using magnetic sensors measured running distance, and the data were recorded daily. Food intake and body weight were recorded weekly. Activity wheels were fixed 18 h before death.
Scoring cachexia.
A strength of ApcMin/+ mice as a cachectic model is variability in the development of cachectic symptoms between mice. To take advantage of this variability, ApcMin/+ mice were categorized on their amount of wasting at the study's end. A cachexia severity score (mild/none = 1, moderate = 2, or severe = 3) based on body weight, gastrocnemius muscle weight, and epididymal fat pad weight was assigned to each animal that had access to a voluntary activity wheel. The weight ranges for each variable were based on the averages of C57BL/6 mice of the same age. Each individual score (body weight + gastrocnemius weight + epididymal fat pad weight) was averaged for a total cachexia score for each animal. A score of "one" was within one SD of the C57BL/6 mean, and these mice had mild/no cachexia. A score of "three" was more than two SDs away from the C57BL/6 mean, and these mice had severe cachexia.
IL-6 overexpression.
An IL-6 plasmid was used to increase circulating IL-6 levels in C57BL/6, ApcMin/+, and ApcMin/+/IL-6−/− mice. Electroporation of plasmid DNA in the quadriceps muscle was used for endogenous IL-6 production and subsequent secretion in circulation. IL-6 plasmid (50 μg) driven by the CMV promoter or empty control vector was injected intramuscularly. Mice were anesthetized with a 2% mixture of isoflurane and oxygen (1 l/min). The leg was shaved, and a small incision was made over the quadriceps muscle. Fat was dissected away from the muscle, and the plasmids were injected in a 50-μl volume of PBS. A series of eight 50-ms, 100-volt pulses was used to promote uptake of the plasmid into myofibers, and then the incision was closed with a wound clip. Mice were electroporated every 2 wk to maintain circulating IL-6 levels using alternate quadriceps muscles. C57BL/6 and ApcMin/+/IL-6−/− mice were killed after 10 wk of IL-6 overexpression. ApcMin/+ mice were killed after 4 wk of IL-6 overexpression since they spontaneously undergo cachexia by 6 mo of age. It should be noted that the quadriceps muscle was not used for any analyses, but rather the gastrocnemius muscle was used to examine the effect of circulating IL-6 on muscle mass.
Plasma IL-6.
Plasma IL-6 levels were measured with a mouse specific ELISA (Biosource, Carlsbad, CA) by taking blood samples under brief isoflurane anesthesia from the retroorbital eye sinus 7 days following each electroporation and at death to ensure validity of the procedure. The IL-6 level for each animal was averaged for all time points assessed over the experimental period. In previous studies using this kit, we have detected 3–30 pg IL-6/ml ApcMin/+ mouse plasma (28, 29).
Tissue collection.
Mice were injected with a ketamine-xylazine-acepromazine cocktail (1.4 ml/kg body wt), and gastrocnemius muscles, epididymal fat pads, tibias, and intestines were excised. Tibia length was measured as an indicator of animal body size. The gastrocnemius muscle was rinsed in PBS, snap-frozen in liquid nitrogen, weighed, and stored at −80°C until further analysis. The small intestines were removed as described previously (29). Briefly, the intestines were dissected, cleared of mesentery adipose tissue, and fixed in 10% buffered formalin for 24 h. Plasma was collected via the inferior vena cava with heparinized needles, stored on ice, and centrifuged at 1,000 g for 10 min at 4°C, and the plasma was stored at −80°C until further analysis.
Polyp counts.
Polyp counts were performed as described previously (29). Briefly, formalin-fixed intestinal sections from all animals were rinsed in deionized water, stained in 0.1% methylene blue, and counted by a single investigator who was blinded to the treatments. Polyps were counted under a dissecting microscope, using tweezers to pick through the intestinal villi and identify polyps. Polyps were categorized as >2 mm, 1–2 mm, and <1 mm in the small and large intestine.
Total RNA isolation and cDNA synthesis.
Total RNA was isolated from the gastrocnemius muscles using TRIzol reagent (Invitrogen, Carlsbad, CA) as previously described (27). Extracted RNA was treated with 10 units of DNase I to degrade any residual contaminating genomic DNA. cDNA was reverse transcribed from 3 μg of total RNA using 1 μl of random hexamers and 50 units of Superscript III reverse transcriptase (Invitrogen) in a final volume of 20 μl at 25°C for 10 min, followed by 42°C for 60 min, and 70°C for 15 min.
Real-time PCR.
Real-time PCR was performed using reagents from Applied Biosystems (Foster City, CA). Gene expression for IL-6 (FAM dye) was carried out in 25-μl reactions consisting of 2× Taqman Universal PCR master mix (AmpliTaq Gold DNA Polymerase, Buffer, dNTP mix, AmpErase UNG, MgCl2), 1.0 μl cDNA, RNase-free water, and 1 μl of primer. Gene expression for cyclophilin (SYBR dye) was carried out in 25-μl reactions consisting of 2× SYBR green PCR buffer (AmpliTaq Gold DNA Polymerase, Buffer, dNTP mix, AmpErase UNG, MgCl2), 0.1 μl cDNA, RNase-free water, and 60 nM of each primer. The sequences for the primers were as follows: cyclophilin forward 5′-TGT GCC AGG GTG GTG ACT T-3′, cyclophilin reverse 5′-TCA AAT TTC TCT CCG TAG ATG GAC TT-3′. Samples were analyzed on an ABI 7300 Sequence Detection System. Reactions were incubated for 2 min at 50°C and 10 min at 95°C, followed by 50 cycles consisting of a 15-s denaturing step at 95°C and a 1-min annealing/extending step at 60°C. Data were analyzed by ABI software using the cycle threshold (CT), which is the cycle number at which the SYBR or FAM fluorescence emission is midway between detection and saturation of the reaction. The 2 −ΔΔCT method (25) was used to determine changes in gene expression between treatment groups with the cyclophilin CT as the correction factor.
Western blotting.
Western blotting was performed as previously described (28). Briefly, frozen gastrocnemius muscle was homogenized in Mueller buffer, and protein concentration was determined by the Bradford (7) method. Crude muscle homogenate (30–60 μg) was fractionated on 8–12% SDS-polyacrylamide gels. Gels were transferred to polyvinylidene difluoride membranes overnight. Membranes were Ponceau stained to verify equal loading of each gel. Membranes were blocked overnight in 5% milk in Tris-buffered saline with 0.1% Tween 20 (TBS-T). Primary antibodies for total and phosphorylated STAT-3 (Tyr705) were purchased from Cell Signaling (Danvers, MA). Antibodies were diluted 1:1,000 to 1:2,000 in 5% BSA in TBS-T followed by overnight incubation with membranes at 4°C. Anti-rabbit IgG horseradish peroxidase-conjugated secondary antibodies (GE Healthcare Life Sciences, Piscataway, NJ) were incubated with the membranes at 1:2,000 to 1:5,000 dilutions for 2 h in 5% milk in TBS-T. Enhanced chemiluminescence (GE Healthcare Life Sciences) was used to visualize the antibody-antigen interactions. Film was digitally scanned, and blots were quantified by densitometry using scientific imaging software (Scion Image, Frederick, MD). The Ponceau-stained membranes were also digitally scanned and the 45 kDa actin bands were quantified by densitometry and used as a protein-loading correction factor for each lane.
Statistical analysis.
Repeated-measures ANOVA was used to examine changes in body weight, food intake, and wheel running activity over time in mice categorized by stage of cachexia. One-way ANOVAs or independent t-tests were used to determine significance for all other variables. Post hoc analyses were performed with Student-Newman-Keul's methods. When the assumption of normality failed, a Kruskal-Wallis one-way ANOVA on ranks was performed. Post hoc analyses were performed with Dunn's method. Significance was set at P < 0.05.
Voluntary activity and body weight.
Body weight was traced over the entire study in ApcMin/+ mice that had access to voluntary activity wheels. There were no differences in body weight between mildly and severely cachectic ApcMin/+ mice at the beginning of the study (P = 0.904; Fig. 1A). The severely cachectic mice started to decrease in body weight by 18 wk of age (P = 0.015) and differed in body weight by the completion of the study at 26 wk of age (P < 0.001). Body weights in severely cachectic ApcMin/+ mice were reduced 20% compared with mildly cachectic mice at the study's end (26.2 ± 0.3 vs. 20.9 ± 0.6 g; P < 0.001). Food intake was also measured weekly; there were no differences between the mildly cachectic and severely cachectic mice at any time point (P = 0.115; Fig. 1B). All of these mice had access to voluntary activity wheels, which were used as an indicator of each animal's health. Running distance per day was not different between the two groups at the beginning of the study (P = 0.975; Fig. 1C). However, by 15–18 wk of age, the severely cachectic mice started to decrease running wheel distance (P < 0.001) and were running significantly less than the mildly cachectic group through the completion of the study.
Muscle and fat pad mass.
Skeletal muscle weights were measured to determine the amount of skeletal muscle wasting in ApcMin/+ mice stratified by their degree of cachexia. Severely cachectic ApcMin/+ mice had a 61% decrease in gastrocnemius muscle weight and complete elimination of the epididymal fat pad compared with mildly cachectic mice (Fig. 2A). Other hindlimb muscles were examined. In severely cachectic mice, soleus muscle mass was reduced 30% (P = 0.003), plantaris muscle mass was reduced 57% (P < 0.001), and tibialis anterior muscle mass was reduced 53% (P = 0.002) compared with mildly cachectic mice. However, tibia length, an indicator of body frame size, did not differ by degree of cachexia (16.4 ± 0.0 vs. 16.5 ± 0.1 mm; P = 0.297).
Polyp number.
To determine whether the intestinal tumor burden varied with cachexia severity, polyp counts were also performed in these mice. Total polyp number was 89% higher in severely cachectic mice compared with mildly cachectic mice (P < 0.001; Fig. 2B). However, when stratified by polyp size, polyps 1–2 mm in diameter and >2 mm in diameter were greater in severely cachectic mice compared with mildly cachectic mice.
Plasma IL-6 and muscle STAT-3 activation.
Plasma IL-6 levels were increased ∼10-fold in mice with severe cachexia (P = 0.020; Fig. 2C). Overall, there was a strong correlation (Fig. 2D) between tumor number and plasma IL-6 (r = 0.789, P = 0.002). To determine whether downstream targets of IL-6 signaling were activated in cachectic muscle, Western blotting was performed to assess STAT-3 activation in mildly and severely cachectic ApcMin/+ mouse gastrocnemius muscle (Fig. 2E). The ratio of phosphorylated STAT-3 to total STAT-3 increased 4.5-fold in severely cachectic mice compared with mildly cachectic mice (P = 0.004). There was a significant inverse correlation between STAT-3 activation (Pi/total STAT-3) and gastrocnemius muscle weight (r = −0.831; P = 0.002). Gastrocnemius muscle IL-6 mRNA did not change with severity of cachexia (38.40 ± 0.35 vs. 38.22 ± 0.25 CT; P = 0.91), suggesting that circulating IL-6 rather than muscle-produced IL-6 was contributing to STAT-3 activation.
IL-6 ablation.
The effect of IL-6 ablation on cachexia development and progression was examined with ApcMin/+/IL-6−/− mice. At 13 wk of age, ApcMin/+ mice had already begun epididymal fat pad loss (Fig. 3A), but there were no differences in gastrocnemius muscle mass (Fig. 3B) between the three strains. At 26 wk of age, ApcMin/+/IL-6−/− mice did not demonstrate wasting and had gastrocnemius muscle and epididymal fat pad masses similar to C57BL/6 mice. Maintenance of fat and muscle mass was not due to increased caloric intake, since daily food intake was actually reduced 11% in ApcMin/+/IL-6−/− mice compared with ApcMin/+ mice (0.147 ± 0.003 vs. 0.165 ± 0.002 g food/g body wt; P < 0.001).
To determine whether skeletal muscle was sensitive to circulating IL-6 levels, Western blotting was performed to determine STAT-3 activation (Fig. 3C). The ratio of phosphorylated to total STAT-3 was lowered 83% in ApcMin/+/IL-6−/− mice compared with ApcMin/+ mice.
IL-6 overexpression.
Mice were electroporated in the quadriceps muscle with either an IL-6 expression plasmid or control plasmid. C57BL/6 mice and ApcMin/+/IL-6−/− were electroporated every 2 wk for a total of 10 wk, starting at 16-wk of age. ApcMin/+ mice were only electroporated for a total of 4 wk since they undergo cachexia spontaneously by 6 mo of age (Fig. 4A). Average plasma IL-6 levels were elevated significantly in mice receiving the IL-6 plasmid compared with mice receiving the control plasmid in C57BL/6 mice, ApcMin/+ mice, and ApcMin/+/IL-6−/− mice (Table 1). The plasma IL-6 levels obtained with overexpression were similar to humans with cachexia before death (21).
There were no differences in body weight at the beginning of the study between the different treatment groups and within any strain (Table 1). ApcMin/+ mouse body weight was decreased 11% by IL-6 overexpression (P = 0.010), and ApcMin/+/IL-6−/− mouse body weight decreased 21% (P = 0.012) compared with mice receiving the control plasmid. ApcMin/+ mice receiving IL-6 had a 70% reduction in epididymal fat pad mass (P = 0.028), and ApcMin/+/IL-6−/− mice had a 63% decrease in epididymal fat pad mass (P = 0.030) compared with control mice (Fig. 4B). IL-6 overexpression in the circulation also reduced gastrocnemius muscle mass 23% in ApcMin/+ mice (P = 0.004) and 32% in ApcMin/+/IL-6−/− mice (P = 0.007; Fig. 4C). Plasmid-based IL-6 overexpression induced cachexia in mice with a polyp burden but not in wild-type mice. The body weights of C57BL/6 mice were not affected by IL-6 overexpression. C57BL/6 epididymal fat pad mass and gastrocnemius muscle weight were not affected by circulating IL-6 overexpression. Food intake was not affected by IL-6 overexpression within any of the strains (data not shown).
During IL-6 overexpression, phosphorylated STAT-3 was induced in all strains of mice (Figs. 4D). It appears that skeletal muscle is sensitive to circulating IL-6 levels and STAT-3 is activated even in the absence of muscle mass loss. Because IL-6 can act in a paracrine manner, gastrocnemius IL-6 mRNA was measured to determine if IL-6 produced by the muscle was responsible for STAT-3 activation. Gastrocnemius muscle IL-6 mRNA did not change with IL-6 overexpression in wild-type mice (P = 0.943) or in ApcMin/+ mice (P = 0.34). Thus changes in skeletal muscle STAT-3 activation appear to be due to circulating IL-6 rather than muscle-produced IL-6.
Polyp burden and IL-6.
We examined if ApcMin/+ mouse intestinal polyp burden was sensitive to circulating IL-6 levels. Total polyp number was 32% lower in the 26-wk-old ApcMin/+/IL-6−/− compared with ApcMin/+ mice (P = 0.014; Fig. 5A). Polyp size was also affected in the ApcMin/+/IL-6−/− mouse with polyps >1 mm in diameter being reduced by 32% compared with ApcMin/+ mice (P = 0.023; Fig. 5B).
IL-6 overexpression increased both intestinal and colon polyp number and size. Total polyp number was 64% greater with IL-6 electroporation in ApcMin/+/IL-6−/− mice (Fig. 5C). Polyps >1 mm in diameter also increased 61% with IL-6 overexpression (P = 0.030; Fig. 5D). Similar results were found with IL-6 overexpression in ApcMin/− mice. ApcMin/+ mouse total polyp number increased 82% with IL-6 overexpression (55 ± 13 vs. 100 ± 5 polyps; P = 0.005). Polyp size also increased with IL-6 overexpression in polyps >1 mm in diameter by 98% (47 ± 14 vs. 92 ± 5; P = 0.005). Overall, these results indicate that changes in circulating IL-6 are associated with a greater tumor burden and a greater loss of adipose and muscle tissue.
A strength of the ApcMin/+ mouse as a cachectic model is the variable wasting seen between mice. This variable wasting rate may be related to significant differences in tumor burden between mice. To examine different stages of muscle wasting, we classified ApcMin/+ mice by the degree of wasting they exhibited. ApcMin/+ mice with the most severe cachectic symptoms also had the highest circulating IL-6 levels and the largest intestinal polyp burden. The importance of IL-6 was also demonstrated by the lack of wasting and a lower overall tumor burden in ApcMin/+/IL-6−/− mice compared with age-matched ApcMin/+ mice. Systemic IL-6 overexpression in ApcMin/+ and ApcMin/+/IL-6−/− mice induced wasting and polyp formation. However, IL-6 overexpression was not sufficient to induce skeletal muscle wasting in nontumor-bearing mice. These data suggest that systemic IL-6 is essential for the development of cachexia in ApcMin/+ mice and is associated with a greater tumor burden.
The current study reports that severity of cachexia in ApcMin/+ mice is associated with both a greater number and larger intestinal polyps. Although others have suggested that cachexia-inducing tumors are not necessarily large tumors (37), our data suggest that a critical tumor burden is necessary to induce cachexia in the ApcMin/+ mouse. The ApcMin/+ mouse primarily develops adenomas, but there is not metastasis (30). It is possible that the increase in adenoma number or growth creates an environment that promotes muscle wasting. Additionally, we had previously shown that plasma IL-6 levels were elevated in cachectic ApcMin/+ mice compared with age-matched, wild-type mice (28). The current study extended this finding by showing that, in 26-wk-old ApcMin/+ mice, increased plasma IL-6 levels were also associated with increased polyp number and size. Because IL-6 is a potent tumor growth factor (8, 13, 34), IL-6 may be leading to an increase in polyp burden, promoting the cachectic environment driven by the tumor. Although the association between high circulating IL-6 levels and muscle wasting has been demonstrated previously (21, 38, 40, 45), the current study shows that even low, chronic levels of IL-6 are associated with muscle mass loss. This is important because the levels of circulating IL-6 seen in ApcMin/+ mice are similar to humans with cachexia (21).
To examine the importance of IL-6 for development of cachexia and intestinal/colon polyps, we generated ApcMin/+/IL-6−/− mice. Unlike 26-wk-old ApcMin/+ mice, age-matched ApcMin/+/IL-6−/− mice did not exhibit wasting of muscle and fat pad mass. This demonstrates the dependence of IL-6 on the induction of cachexia. These data coincide with other models of cachexia showing that blocking the effects of IL-6 have positive effects on skeletal muscle mass (14, 35, 39, 44). In the current study, ApcMin/+/IL-6−/− mice also had a lower intestinal tumor burden than ApcMin/+ mice. Although tumor growth is associated with cachexia, many studies that delay or reverse cachexia through the inhibition of IL-6 or other inflammatory cytokines fail to detect a change in tumor growth (5, 10, 35). This may be related to the tumor model used to induce cachexia. An advantage of the ApcMin/+ mouse is the ability to count and classify by polyp size throughout the intestine and colon. Therefore, it is possible that the ablation of IL-6, which leads to preservation of muscle and fat mass in ApcMin/+ mice, is mediated through the inhibition of tumor growth. One limitation of the ApcMin/+/IL-6−/− mouse model is that IL-6 is ablated in both skeletal muscle and tumors, making it impossible to determine the source of IL-6 that is important for the induction of cachexia. Nevertheless, this has important implications for clinicians treating cachectic patients because methods for controlling the increase in plasma IL-6 seen during cancer may be beneficial for both suppressing tumor growth and maintaining skeletal muscle and adipose tissue mass.
To determine if IL-6 was sufficient to induce cachexia, circulating IL-6 was increased in wild-type, ApcMin/+, and ApcMin/+/IL-6−/− mice. Although the circulating levels obtained through overexpression were physiological, it should be noted that these were at least 10-fold higher than those seen in cachectic ApcMin/+ mice. Overexpression of circulating IL-6 induced wasting in both ApcMin/+and ApcMin/+/IL-6−/− mice but not in wild-type mice. Others have also shown that IL-6 induces cachexia in mice with tumors (33, 35, 43), similar to our finding in ApcMin/+ mice. Additionally, ApcMin/+and ApcMin/+/IL-6−/− mice receiving IL-6 also had a greater tumor burden than mice receiving the vector control. An additional finding of the current study was that elevated circulating IL-6 induced wasting and polyp growth in the absence of tissue-level expression. ApcMin/+/IL-6−/− mice lacked IL-6 expression in intestinal polyps, adipose tissue, and skeletal muscle and underwent cachexia in the presence of high circulating IL-6. It has been suggested that tumor-produced IL-6 is essential for cachexia (44), but the current study does not support tumor production of IL-6 as necessary for the induction of cachexia. In addition, IL-6 did not induce wasting in wild-type, non-tumor-bearing mice, suggesting other factors related to the overall tumor environment may also be involved in the regulation of cachexia. Further work is needed to discover the specific interaction between the tumor and IL-6 that mediates wasting.
IL-6 signaling at the cellular level involves the phosphorylation and dimerization of STAT-3. The current study examined STAT-3 phosphorylation in wasting skeletal muscle. Skeletal muscle STAT-3 activation has been detected in other forms of atrophy, such as sarcopenia (18) and following crush injury (22), but STAT-3 activation has not been studied during cancer cachexia. Greater muscle STAT-3 activation was associated with more muscle mass loss in ApcMin/+ mice. Overexpression of circulating IL-6 in ApcMin/+ mice did induce STAT-3 activation. However, STAT-3 activation also occurred in wild-type mice that did not have muscle wasting. Although skeletal muscle STAT-3 phosphorylation is sensitive to circulating IL-6, this signaling pathway does not appear to be sufficient to induce skeletal muscle mass loss. This adds further support that indirect mechanisms of IL-6, possibly related to other factors related to the overall tumor burden of the animal, are important for inducing muscle mass loss during cancer.
Perspectives and Significance
This study supports a role of systemic IL-6 in the development of cachexia and intestinal polyp growth in the ApcMin/+ mouse. ApcMin/+ mice exhibiting a greater severity of cachexia and a larger intestinal tumor burden also had the highest circulating IL-6 levels. Circulating IL-6 overexpression also accelerated ApcMin/+ mouse cachexia and increased intestinal polyp number. Wasting was not induced by circulating IL-6 overexpression in wild-type mice, which have no intestinal tumors. Together, these data suggest an interaction between intestinal tumors and high circulating IL-6 levels, which create an environment favoring catabolism of skeletal muscle and adipose tissue. This was further demonstrated by the absence of cachexia in tumor-bearing mice that lack IL-6 and adding back systemic IL-6-induced cachexia in these mice. These findings have important implications for treatment of cancer and the associated cachexia. The ability to inhibit specific targets of IL-6 regulation may serve beneficial to both tumor progression and the maintenance of total body mass. Future work will attempt to identify muscle-specific and other systemic-related changes induced by IL-6 that promote adipose tissue and muscle catabolism.
The research described in this report was supported by National Insitute for Research Resources Grant P20 RR-017698.
We thank Tia Davis for technical assistance and Dr. John Baynes for critical review of the manuscript.
The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2008 the American Physiological Society


text:
"Acute Mental Health Services in Stoke on Trent"
About: North Staffordshire Combined Healthcare NHS Trust / Adult mental health North Staffordshire Combined Healthcare NHS Trust Adult mental health ST2 8LD North Staffordshire Combined Healthcare NHS Trust / Inpatient mental health care North Staffordshire Combined Healthcare NHS Trust Inpatient mental health care ST2 8LD
Posted by Roxanne (as ),
I experienced good and bad treatment at the hands of some nursing and care staff on Ward 3 of the Harplands Hospital, Hilton Road, Stoke-on-Trent.
Four staff behaved correctly and helpfully throughout my stay.
A number of other staff were doing their best in very difficult circumstances.
Some other staff, both staff nurses and health care workers, seemed set on making life as difficult as possible for in-patients, or at least behaving in such a way as to intimidate and suppress patients' well-being.
Response from North Staffordshire Combined Healthcare NHS Trust 5 years ago
Can I thank you for taking the time to provide us with some of your experiences whilst on Ward 3. We will ensure the positive comments you have made are feedback to staff. However it would be useful to follow up with you some of the comments which were not so positive and explore these in more detail to see how we can ensure services are further improved. You can do this by contacting;
Emma Ball, Ward Manager on 01782 441703 who will be happy to meet with you. Alternatively please contact our Patient Advice and Liaison (PALS) Team on 0800 389 9676 (free phone) or via email email@example.com and a member of the PALS team will arrange to meet with you at your convenience to discuss your issues in more detail.
With kind regards
Jane Clement
Service Line Manager - Psychosis Recovery Pathway
- {{helpful}} of {{total()}} people think this response is helpful
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Thank you for your feedback.
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Added: Thursday, September 26, 2013
Loading Pornstar Spa Sadie Santana: Sadie Wants Her Pussy Massaged! Video
This week Sadie Santana gets a nice rub after a tense work out. So we had a specialist come in and massage all the important parts and give her that deep attention. She was very grateful as she got her ass massaged and her pussy squeezed. Then she got to suck some dick while she had her breast massaged. Sadie was a happy girl and at the end she got a happy fucking ending to make her day.


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By Tom Winnifrith | Friday 29 April 2016
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from ShareProphets). I have no business relationship with any company whose stock is mentioned in this article.
Earlier this week I ran an article which David Lenigas responded to by accusing me of getting my facts wrong and thus been a pathetic sad person and poor journalist. It is at least better than tweeting about my mother's suicide 40 years ago. I demonstrated HERE that Lenigas was 100% wrong, my facts were 100% right and that he was a smearing, liar, happy once again to mislead his investors. Tomorrow at UK Investor Show I shall demonstrate he is much much worse. Lenigas has responded to his impending downfall with a new tweet.
David, my language is awful. But at least I tell the truth and get my facts right which is why the chairman of the LSE reads my work and the FRC congratulates me for it. No doubt your small number of moronic followers and legions of bogus twitter accounts that follow you will vote otherwise. The opinions of morons do not matter.
You, on the other hand, are a serial liar. 2 D seismic no 3d, LGO. REM, etc etc etc are not having placings, the wrong Rushmans, this is the "seed capital" funding for Cuba, the list of your lies goes on and on and on. And as a PLC director, shadow and real, your serial lies do matter.
Tomorrow I will have new revelations which will shock even the morons who retweet you today. I look forward to exposing you for what you are at UK Investor show
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This area of the ShareProphets.com site is for independent financial commentary. These blogs are provided by independent authors via a common carrier platform and do not represent the opinions of ShareProphets.com. ShareProphets.com does not monitor, approve, endorse or exert editorial control over these articles and does not therefore accept responsibility for or make any warranties in connection with or recommend that you or any third party rely on such information. The information available at ShareProphets.com is for your general information and use and is not intended to address your particular requirements. In particular, the information does not constitute any form of advice or recommendation by ShareProphets.com and is not intended to be relied upon by users in making (or refraining from making) any investment decisions.
6 comments
judith w
A song sung by both John Lennon and Bryan Ferry comes to mind….
Probably too dense to work it out and this post wont see the light of day you fascist freedom of speech denier
You always insist when posting your praise of Jabba/attacks on me here that I am a fascist free speech denier and I always publish your shite. What dont you understand about what free speech actually means you half-witted bint?
I am not a jealous guy. Well maybe jealous of whoever is entertaining Cheryl Cole right now but not of a fat lying tool like Lenigas. What a horrible way to live.
Anyhow must rush, am planning to be va Spaniard in the works for some high profile crooks tomorrow. Bring down the crony capitalists and be a working class hero. etc
Thought she meant lets get together
Thought she meant lets get together
william carr
I do not know why this piece of shit is not in prison Lenigas is a cunt we have lost £15,000 in his companies because of his lies, I would willing shoot the fucker in a just world where thieves with connections shaft us
Oh the delights of predictive or voice typing : va Spaniard instead of "the spanner" made me laugh . Next time I am fettlin the Moat ahhh I can say " pass me a 10 mm spaniard will ya " Probably pretty accurate actually .TW Note - That was deliberate. It was a John Lennon reference. A Spaniard in the Works is his book of poetry!!
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Below is a cross-section of a stock D/P VW Cylinder Head, next to a cross section of a 044 Cylinder Head. Note the difference in the spark plug holes.
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Looking for a premium crossover? This one has a bottle chiller in the back and a solid gold clock.
The Bentley Bentayga is one of the most luxurious crossovers in the world straight off the showroom floor, but the brand is now upping the level of opulence even more for truly posh customers by introducing the new Mulliner trim. The one going on display in Geneva is a unique example that has a specially inlaid front fascia depicting the Monte Rosa mountain range.
The range-topping Bentayga needs a suitably potent engine to get around, and the Mulliner is only available with the 6.0-liter W12 with 600 horsepower (447 kilowatts) and 663 pound-feet (900 Newton-meters) of torque. It propels the big crossover to 62 miles per hour (100 kilometers per hour) in 4.1 seconds and a top speed of 187 miles per hour (301 kilometers per hour).
The Mulliner is available with Bentley's roll reduction tech that uses a 48-volt electrical system to adjust the suspension during cornering for a flatter ride.
On the outside, Bentley doesn't really advertise whether a Bentayga has the Mulliner spec – other than adding a badge. The only major changes are body-color lower trim and chrome bumper grilles in the fascia. It also rides on seven-spoke 22-inch wheels. Two-tone paint is an option but becomes available on the standard Bentayga in April.
The Mulliner really shows why it's so special on the inside. Buyers can choose different colors for the front and rear seats, and they have seven shades to pick from. Ombré Burr Walnut Veneer wood trim is only available on this model. For true opulence, customers can spec an optional Breitling clock that comes in solid gold and has a dedicated winding mechanism.
Passengers in the rear find a bottle cooler in the console that includes Cumbria Crystal flutes. While enjoying a drink, occupants can pick from six levels of mood lighting that adjusts the illumination from the doors, armrests, and foot wells. Owners can even prep the cabin to their liking with the Parking Heater that lets them set the interior temperature when away from the vehicle.
The Bentayga Mulliner goes on sale this spring, but Bentley is clear that the model only available in limited numbers because of the work necessary in crafting such a luxurious cabin. The company isn't talking about the price, but it's safe to assume that the figure is more than the SUV's roughly $230,000 base price. Expect to only see royalty and captains of industry driving one of these.
Source: Bentley


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STARmeterSEE RANK
Down 61,366 this week
Patrick Modiano
Patrick Modiano was born on July 30, 1945 in Boulogne-Billancourt, Hauts-de-Seine, France. He is a writer and actor, known for Lacombe, Lucien (1974), Bon voyage (2003) and Une jeunesse (1983). He has been married to Dominique Zehrfuss since September 12, 1970. They have two children. See full bio »


text:
Asian stock markets turned in a mixed performance in light trading Thursday, as Hong Kong gained but Japan fell on a weaker U.S. dollar, and Shanghai also declined. Other regional exchanges were also uneven, following the overnight drop on Wall Street.
In Tokyo, the Nikkei 225 fell 1.32% after Wall Street fell overnight and the yen rose in same-day trading against the U.S. dollar, the latter regarded as a negative in export-oriented Japan.
Electronics-and-industrial conglomerate Toshiba (TOSBF, 6502:Tokyo) again led losers, off 17.5% and marking its third-straight day of double-digit losses following news that the company will report losses on North American nuclear power-plant operations.
In other news, Japan's GDP rose 0.4% in the month in November, the third-straight monthly gain, reported the Japan Center for Economic Research. Exports rose 3.3% on the strength of Asian consumption. Bank of Japan Governor Haruhiko Kuroda said the global economy is growing, but his 2% inflation target for Japan will likely not be hit in 2017.
By BDL Contributor


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|By Peizhi Liu
|See other fanon and fan fiction works from Peizhi Liu.
The fashion of the Shen Wuzi people is very traditional. The men typically wear their hair in a topknot, ornamented with various holders and pins, and often have beards and/or mustaches. Women wear their hair down or piled on top of their head.
The village was the original birthplace of the Mu Lieren (木猎人), a group of elite hunters made up entirely of Woodbenders. Although many years ago only males were allowed to join, females have now been permitted to become members of the Mu Lieren due to the new law placed by current Lead Huntress Biyu.
See more
For the collective works of the author, go here.


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The company has also recorded increase by 20.5 per cent in net profit to Rs. 1,46,176 lakh in the quarter ended March 2011 from Rs. 1,21,287 lakh in the quarter ended March 2010.
Moreover, the expenditure also increased to Rs. 1, 53,884 lakh in the March 2011 quarter from Rs. 87,712 lakh in the corresponding quarter last year. The other income of the company surged to Rs. 16,899 lakh from Rs. 7,365 lakh in the quarter ended March 2010. The paid up equity share capital of the company in the quarter ended March 2011 amounted to Rs. 8,691 lakh from Rs. 8,310 lakh.
For the period of year ended March 2011, the total income increased to Rs. 9, 20,512 lakh as compared to Rs. 5, 85,829 lakh in the corresponding period last year. The other income during the year ended March 2011 amounted to Rs. 53,989 lakh as compared to Rs. 30,406 lakh in the year ended March 2010. Moreover, the net profit during the period rose to Rs. 4, 22,245 lakh from Rs. 2, 62,913 lakh in the period of year ended March 2010.
Further, during the fourth quarter the company acquired assets of Steel Plant of Bellary Steel and Alloys Limited for at Rs. 220 crore. It has also acquired d 10.4% Stake of Cairn India Ltd. from Petronas. Further, the Supreme Court of India has approved the amalgamation of Sesa Industries Limited (SIL) with Sesa Goa Limited (SGL).
During the quarter, the sales of iron ore has improved, which stood at 6.7 million tonnes from 6.6 million tonnes in the corresponding quarter last year. However, the sales for the year stood at 18.1 million tonnes as compared to 18.4 million tonnes sales last year. The production of iron ore was down by 20 per cent during the quarter ended March 2011 at 5.5 million tonnes as there was a state-wide export ban in Karnataka, which was imposed since end of July 2010 and closure of the third party mining agreement in Orissa in November 2010.
However, the Supreme Court has declared that the Karnataka export ban would be lifted from 20 April 2011. The final hearing of the case is expected to be scheduled in the first week of May 2011.
As the company had focussed on the exploration activities at its operations at Goa and Karnataka, there was a gross addition of 53 million tonnes of reserves and resources as compared to a prior depletion of 21 million tonnes during the year.
Additionally, the board of directors of the company at a meeting conducted on April 25, 2011 has recommended a dividend of Rs. 3.50 per equity share of Rs 1 each for the current financial year as compared to Rs 3.25 per equity share of Rs 1 each in the previous year.


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1950s Movado Kingmatic With Rose-Gold Indexes
Why This Watch Matters
This Kingmatic caught our attention with its waterproof case, elegant rose-gold indexes, and the beautiful patinated lume plots. This is a dress watch that you don't see often.
The Full Story
During the 1950s, Movado was considered to be one of the greatest watchmakers, which you can see in this Kingmatic. This a pretty special dress watch – it has some fairly uncharacteristic features with lume plots on the dial and a waterproof case from the casemaker Borgel (the same maker that produced the case for the Patek Calatrava reference 2508). This Movado is both functional and elegant, from the elongated lugs to the stunning rose-gold indexes. Complete with our black croc strap, you can be sure this is a stunner.
The Fine Print
Maker: Movado
Model: Kingmatic
Reference: NA
Year: 1950s
Case No: 445375-11179
Material: Stainless Steel
Dimensions: 35 mm diameter; 12 mm thickness
Sapphire Crystal: No
Lume: Yes
Caliber: Automatic caliber from Movado
Bracelet/Strap: HODINKEE Black Crocodile Strap
Lug Width: 18 mm
Box/Papers: No
The Nitty Gritty
This Movado Kingmatic is in lovely condition, with a sharp case and a near-perfect dial. The waterproof case shows light previous wear, with superficial scratches on some facets of each lugs. The dial could be considered "flawless" as the lume on the hands match the lume plots. Additionally, we can't complain about the enticing shine of the rose-gold indexes. Note that there is some light oxidation to the second hand that is visible only through a loupe.
The HODINKEE Guarantee of Authenticity
First and foremost, we certify that this watch is authentic and guaranteed to be as described to the best of our knowledge. Nothing is more important to us than a clear and transparent transaction that makes our end-consumers happy – so if something goes wrong, you have our word that we will do everything possible to make it right.
30-Day Mechanical Warranty
Each watch is guaranteed by a 30-day mechanical warranty that we believe to be the most comprehensive in the industry. We stand behind every item we sell, though due to the nature of vintage watches, we expect reasonable treatment of all watches by their owners. Each watch is known to be working before shipment, though we make no statement about mechanical accuracy or waterproofing.
Each watch is covered by a no-questions-asked five day inspection period. The watch, however, must remain unworn and unmolested within that period of time – and in the same condition in which it left HODINKEE. If a return is requested, simply email firstname.lastname@example.com and we will respond with instructions. Insured shipping for returns must be paid for by the buyers and buyers assume all risk.
Orders placed Monday through Friday from 9:00 A.M. EST to 5:00 P.M. EST may be edited or cancelled within 1 hour of order placement. Orders that are shipped before a cancellation has been confirmed must be returned according to the guidelines featured above.


text: You can submit your prayer request or praise below. Unless you request otherwise, we will not share your information with anyone except our Alumni Office and Alumni Board prayer team. If you have questions, feel free to contact us. Thank you for being part of the SPU Alumni Prayer Network.


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help UDF
Hi. I'm using a DEFINE_INIT macro to define memories with (C_UDMI(cell,thread,0) for store the mass of particle. compiling my UDF is OK, But when I write UDMI0 , the value is 0, I dont' know where is the problem can somebody help me please? thanks my UDF is:
#include "udf.h" #define MIN_IMPACT_VELO 0.0001 Domain *domain; DEFINE_DPM_EROSION(dpm_accr, p, t, f, normal, alpha, Vmag, Mdot) { real A[ND_ND], area; int num_in_data; Thread *t0; cell_t c;
real radi_pos[2], radius, imp_vel[2], vel_ortho; radi_pos[0] = p->state.pos[1]; /* Radial location vector. */ radi_pos[1] = p->state.pos[2]; /* (Y and Z in 0 and 1...) */ radius = NV_MAG(radi_pos); NV_VS(radi_pos, =, radi_pos, /, radius);
/* Normalized radius direction vector.*/ imp_vel[0] = P_VEL(p)[0]; /* Axial particle velocity component. */ imp_vel[1] = NVD_DOT(radi_pos, P_VEL(p)[1], P_VEL(p)[2], 0.); vel_ortho = NV_DOT(imp_vel, normal); /*velocity orthogonal to wall */ if(fabs(vel_ortho)< MIN_IMPACT_VELO)
C_UDMI(c,t,0) = C_UDMI(c,t,0)+ P_MASS(p); return; }
DEFINE_INIT(my_init,domain) { Domain*Domain =Get_Domain(1); Thread *t; cell_t c;
thread_loop_c(t,domain) { begin_c_loop_all(c,t) { C_UDMI(c,t,0)=0.0; }end_c_loop_all(c,thread) } }
Re: help UDF
try changing the line C_UDMI(c,t,0) = C_UDMI(c,t,0)+ P_MASS(p);
to this C_UDMI(c,t,0) += P_MASS(p);
Re: help UDF
Hi thanks to your Re. i try changing that line,but it is no any change to UDMI. could you give me some other advise?
Re: help UDF
Have you checked wether your conditional statement: if(fabs(vel_ortho)< MIN_IMPACT_VELO) ever becomes true? Markus
Re: help UDF
hi: thanks to your Re. I am a new FLUENT, i don't known how to checked the conditional statement:if(fabs(vel_ortho)< MIN_IMPACT_VELO). could you give me more help?
Re: help UDF
You can check it with a UDM. Before the conditional statement put: C_UDMI(c,t,1) = 0;
After the conditional "if" statement put: C_UDMI(c,t,1) = 1;
Then run the problem and if UDM 1 is equal to 1 in any cells then the conditional statment is true.
Re: help UDF
hi: thanks to your Re. By checking UDM,i know that the conditional "if" statemen is not use to judge. But why is it no use? how to revised the UDF i ought to ? i think that maybe other line is wrong in the UDF.
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Accent your seating area by bringing an opulent and impressive traditional style of the Blake Chaise. The wooden frame is finished in Pearl White with hand carved gold accents. Accented with crystal tufting on backrest, rich fabric upholstery looks very exquisite, creating a beautiful play of colors and patterns.Includes
1 Chaise.
Other Decorations are NOT included.
Chaise: 70.5"L x 38"D x 44"H
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Additional Information
SKU 30500383 MPN 687-CH GTIN UPC 635963990237 Brand Meridian Furniture Collection Grace Assemble Length N/A Assemble Width N/A Assemble Height N/A Assembly Required Yes Material N/A Color N/A Styles Contemporary Shipping Time 2-3 Weeks Free Shipping Yes
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