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Before purchasing that primary or adjacent home, in attendance are 3 holding you should truly do until that time business your actual belongings agent or security interest bourgeois. It is considerable to make out where you are financially formerly your hunch becomes set on that flawless place of abode. By reckoning out your net worth, your unit of time budget, how much indebtedness you pay both period and what your Gross Debt Service (GDS) and Total Debt Service (TDS) ratios are you will have a higher kindness on how markedly you can drop on that new flat.
1) Net Worth
Simply explicit your net rate is the unlikeness relating your Assets what you own and your Liabilities, what you owe. It is eminent to canvass your net charge anterior to track and field into the hall purchasing marketplace. One it gives you an accurate gawp at your current economic situation, and two when it is time to reach a deal to your mortgage factor or loaner you will previously cognize the answers to their questions. It is in good health to be cognisant of your financial figures antecedent to this reunion so the action you receive will not locomote as a realized amazement. Knowing your net worthy will confer you a redeeming witness of how so much of a trailing expense you will be competent to afford.Post ads:
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2) Budget and Debt Payments
If you haven't through so preceding to buying your house, you should at smallest possible fabricate a record or monetary fund of your unit of time funds and liability payments. It is smashing to cognise how a great deal of a mortgage clearing you can realistically afford. A time unit proof of purchase of your expenditures and liability payments will elasticity you a stoppage of where on earth your hoard is beingness tired. Once you know how more you spend on heat, electricity, cable, groceries, and all those unit of time expenditure that be to slope up on us, you can see what caring of security interest pocket money will fit comfortably into your budget.
3) GDS & TDSPost ads:
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Almost e'er lenders will use two methods to determine what you can afford as a monthly security interest expenditure. The GDS determines the time unit housing reimbursement as a proportion of your pure gross monthly capital. Your sum suburban cost payments can not outdistance 32% of your total time unit proceeds. These reimbursement normally involve primary and go of a mortgage, taxes, and calefactory outlay. For taster if you post-free $1000 unit of time mortgage fee (Principal & Interest), with $100 for taxes, and $100 for heat, you pay $1200 entire unit of time living accommodations outgo. If you get $5000 a calendar month in gross proceeds your GDS would be $1200/$5000 = 24%. The TDS is an step-up of the GDS, on next to unit of time inhabited expenditure payments all else debts such as loans and appreciation game are likewise considered. In this skin your TDS can not outclass 40% of your time unit gross financial gain. Taking our ultimate example if we add $500 a period of time in different indebtedness our TDS would be $1700/$5000 = 34% As you can see in that is a lot of pre-work earlier you want to hit the paved surface. It is always a obedient perception to sit backbone cart an hour or two and digit out where on earth you are financially previously discussion to that mortgage factor or concrete holding agent. It may save a lot of people, a lot of case or you perchance terrifically cheery to learn you can afford more than you looked-for.


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
See below.Asked by Josh Feingold on July 27, 2015 at 09:42 AM
I am working with a non-profit that has a two part approval process, whereby the user submits data though a form, to include a particular approver within the organization, needs to edit a subset of that data, which then gets forwarded to a third person. Will your form solution allow for this functionality? If not, do you have any suggestions of one that will?
Hello Josh,
At the present we don't have a readily available workflow implementation, you can however achieve it using form conditions.
You can use the conditions to keep each approver field hidden until a specific code is entered once it its entered it will show the option to approve the submissions.
To get the approver to edit the submissions you can add the edit submissions link in the notification email
Here is s sample form showcasing the approver section, you can clone it and use it as a basis for you approver conditions
If you need further guidance and assistance please let us know.
Thanks! Question though. With the password conditional piece... if
someone views the source of the form, would they be able to break the
security, or does it test the password against a server before it shows the
conditional piece? Thanks!
Hi joshfeingold,
Yes the conditional password would be able to viewed from within the full source code of the form. It would however take someone with web development knowledge to know exactly what to look for.
Please inform us if you need further assistance.
Thank you

subset: commoncrawl


text:
Reviews For
Glytone Acne Treatment Spray for Back and Chest 2 fl oz
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Write a Review - Receive 50 Rewards Points!
Tell us your thoughts about Glytone Acne Treatment Spray for Back and Chest 2 fl oz so we can help you find the right products. With your review, you'll also receive 50 Rewards Points. Please note that it may take up to 72 hours for a review to appear on site. All reviews are subject to moderator approval.Write a Review
This is perfect for my son to spray on his back. He plays sports and his bacne was out of control because of it. This cleared it up and it's easy enough to use that even a lazy teen can manage it!
Not a bad body spray, but not my favorite. This one at least doesnt make me cough.
I love this spray. It does what it says. You do need to follow the instructions like it says and spray in a very well venhilated room because if you inhale it you will have a cough atttack, but I knew from reading instructions and seeing other reviews to spray it on in my bedroom where I have a ceiling fan! It works like magic though!
Love that I can carry it around in case of emergency.


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Swedish-based Metro International, the international newspaper group which publishes the vastly successful range of Metro free newspapers, has announced that it had entered into a joint venture and franchise agreement in Ecuador with local media group Grupo Hoy. Grupo Hoy already publishes the existing free newspapers Metro Hoy in Quito and Metro Quil in Guayaquil (together "Metro Ecuador").
Metro Ecuador was re-launched under Metro International's global newspaper format a week ago today under the banner of a new Joint Venture Company -- Diarios Unidos Del Ecuador S.A ("DIUNESA"), which now owns 100% of Metro Ecuador. Metro International will initially retail a 15% equity interest in DIUNESA, with an option to increase this shareholding in the future. Apart from a share of the equity, Metro International will receive franchise fees reflecting its operational support of the joint venture.
Following the launch of its two editions in Ecuador, Metro has become the largest newspaper in Latin America. It distributes over 500,000 daily copies in six major cities in four countries: Mexico City, Monterrey, Sao Paulo, Santiago de Chile, Quito and Guayaquil.
The technique of franchising is highly developed in the retail, hotel and fast food sectors, but is far less often seen in publishing. The market power and brand recognition enjoyed by Metro provide an ideal means of scooping advertising income in markets which have yet to yield to the charms of internet ads.
Wednesday, 22 July 2009
Metro franchise reaches Ecuador
Posted by Jeremy at 13:39
Labels: Ecuador, franchise, newspaper distribution
1 comment:
- jonathan said...
The opening will be great for local entrepreneurs. I hope they work well. Thank you.
- 24 July 2009 at 13:06
Subscribe to: Post Comments (Atom)


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
My exwife moved out of state (NJ to VA) with my 3 children back in 2009. My relationship with the children 11, 13, & 16 is deteriorating. It's hard to fix 8 hours (500 miles away). They won't even return my calls or texts now. I asked my ex what was going on and she "I suggest you figure out a way to reach out to them. I will not get in the middle of your relationship with them'. Our PSA states that she is assist in a nurturing relationship. Is this enough for change in circumstances-to try to have her relocate back to NJ with them?
Your question raises some very difficult issues, and I am sorry that you are experiencing this. However, pertinent facts were missing from your synopsis which would help a lawyer, especially one experienced in family law, be better able to guide you. Based on the reference to your PSA, you certainly have a hook. However, pursuant to the UCCJEA, your children's "home state" can now be considered Virginia. It is very relevant what your PSA or the Order allowing the move stated about jurisdiction, etc. because WHERE an application would be filed, regardless of what you are file, is an overarching question at this stage. Additionally, you reference the concept of HER relocating back to NJ; it is not impossible but it is highly unlikely a Judge would order that she relocate. You may, based on a number of factors, be able to request the children's move back to NJ, but this is a highly fact-sensitive issue and turns on a lot of specific information which cannot be ascertained from your explanation above. I strongly urge you to consult with an experienced family lawyer who can review your documents, discuss the pertinent facts, and give you tailored advice on how to proceed. Good luck.
The information presented in this answer is for informational purposes only. The answer or the information contained within should, in no way, be construed to be formal legal advice nor the formation of a lawyer/client relationship.Ask a similar question
Does your PSA state what state will have jurisdiction in case of conflict? You need to have an attorney of that state review your PSA. If it is silent on the state, then Virginia would be the children's home state.
Please be advised my answers to questions does not constitute legal advise and you should not rely on it, due to the fact that we have never met, I have not been aprised of the facts in you case nor have I reviewed any documents.Ask a similar question
You will likely not have enough to force a change in custody from VA to NJ
DISCLAIMER This answer is provided for educational purposes only. By using or participating in this site you agree and understand that there is no attorney client privilege between you and the attorney responding. This site cannot be used as a substitute for competent legal advice from a licensed attorney that practices law in the State where this offense is charged; and, who has experience in the area of law you are asking questions about and with whom you would have an attorney client relationship. The law changes frequently and varies from jurisdiction to jurisdiction. The information and materials provided are general in nature, and may not apply to a specific factual or legal circumstance described in the question, or in the State where this charge is filedAsk a similar question
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text: March 20, 2017 Posted By Banks Lee Leave a Comment Daycation Kingdom – 'Lunch at Dave and Busters' – Episode 80 – March 20, 2017 This week, join Mike and Frauke as they meet with friends for lunch at Dave and Busters on International Drive. Be sure to follow Daycation Kingdom on Facebook & Twitter. Related


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login with
I so need to but we had some seed organization to do and so cleaning will have to be done tomorrow.
About Leah Carlson
Born: Troy, Ohio
Current: Troy, Ohio
Birth: December 10
On Moms.com since: Nov 8, 2013
I am Leah, a 26 year old first time mom. My daughter Holly was born March 9,2013. I am primarily a stay at home mom but also work part time as a Figure Skating Coach. My husband and I are enjoying life as new parents. SITE HOSTESS


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Alison Holland, Site Manager.
Alison was appointed camp manager in April 2008 and moved into the cottage with her husband Martin, having previously worked at the Bible College of Wales in Swansea. Married for 35 years, they have three grown up sons, three gorgeous daughters-in-law and two beautiful grandsons. Alison is a trained teacher and has also worked in global logistics for many years.
Nathan Holland, Extraordinarilly Brilliant.
Nathan is usually found in the office working on publicity material or the website during the quieter months. During the spring and summer school terms Nathan is more often found outside working (playing) with the school groups staying on site. Nathan lives in Loughor with his eight year old son, Joshua (who has a cracking left foot) and his wife, Charlotte (who doesn't). He supports the Nottingham Forest and eats lots of biscuits.
Charlotte Holland, Education Ranger and Housekeeper
Charlotte is part of the Education team. She's usually the timekeeper/organiser, and is the only member of the team with a vaguely level head. Charlotte really enjoys some of the stranger sports the St Madoc Centre staff play, as well as searching the surrounding lands for snakes and reptiles.
Gary Warden, Caretaker Extraordinairre
Gary grew up just down the road in Three Crosses, but for much of his life has lived and worked elsewhere. Now living on Gower again, he joins us in a Caretaking role, and his daily routine can include mending beds, changing light bulbs, pulling weeds, and so much more!
Jan Manley, Office Ranger
Jan lives in Three Crosses with her husband of 30 odd years and her two grown up sons and likes walking, swimming and cycling. Jan has worked in a wide range of roles in the past including admin, health, social care, welfare, and education. Jan's job here is largely office based. She makes sure that the school groups that come to stay with us know what to bring, when to come and where we are! She helps to look after the site, and loves feeding the lambs!


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"It costs an average of N2 billion to run that office and all the office does is to create confusion. If you do away with it, you have saved a state government of N2 billion and N72 billion for all 36 states" he said.
He narrated how he had to cut down on his aides and government officials that accompanied him to Abuja so he could save some money for his state
"When I came into office, my first trip to Abuja I traveled with over 30 people. Everybody had a title to be in the plane. So I asked myself, I am the only one being invited to Abuja. I pay for 30 people to Abuja, constitute a problem to the traveling public, I am the one going to Abuja for a meeting. Because they are idle and in the hotel, they eat more so I have a lot of bills to pay. In the end, every trip was costing me N10 million and at times I do this four to five times in a month so I had to ask what the purpose of each person in Abuja and I found out the only person who was needed in Abuja was me" he said.
https://t.co/t4DAvPrJHa via @youtube
Peter Obi's speech at the platform.
— ijeoma Ezeasor (@EzeasorIje) October 2, 2016
Why not leave women and Americans alone this morn and watch Peter Obi's very good Platform speech on cutting govt expenditure on YouTube.
— Funmi Iyanda (@Funmilola) October 2, 2016
Compare Peter Obi's independence day speech with that of the presidency, you will know the true meaning of competence.
— SEGUN (@SegunAndrews) October 1, 2016
Do u want entertainment?
Pick a copy of today's speech by our President.
For hw good governance operates?
I recommend that of Peter Obi.
— SEGUN (@SegunAndrews) October 1, 2016
Yesterday's Platform speech by Peter Obi is one that will make him the President of Nigeria in the coming years.
— Ross Alabo-George (@imaginasion1) October 2, 2016
1 @atiku sir good morning, I hope u watched Peter obi speech. I will suggest that u make him your VP candidate for 2019
— Ifeanyi (@princelouis101) October 2, 2016
Just listened to Peter Obi's speech. Very well delivered.What I found sad though was everything he listed was intuitive unless you're greedy
— Damocles (@Damocleansword) October 2, 2016
Come to think of it, it is more impressive that Peter Obi made that 40mins speech without any papers, that's wow
— O. (@Onyicks) October 2, 2016
Just watched Peter Obi's speech on youtube and I think his messages was d best ever have heard from any living politician in Nigeria
— Arowolo Abayomi G (@aromedprem) October 1, 2016
Peter Obi has suddenly become the best gov in Nigeria history with today's speech….@jag_bros . So many key point students on twitter!
— Moshood (@AbdSalam_MO) October 1, 2016
What will make Peter Obi's speech very popular going forward is not its practicality, but the simplicity of the language he used.
— Gboye (@mcgboye) October 1, 2016
If there's any take home from Peter Obi's speech its that we should stop celebrating criminality nd start asking questions #MakeNigeriaWork
— Zikar Elendu (@Zikarr_) October 1, 2016
Peter Obi"s speech at #ThePlatform can be likened to the one Obama gave at the DNC congress in 2004.It set the stage for bigger things.
— Charles Obi (@obiedu) October 1, 2016
"Youths .. Go and join Politics"… Thats the ONLY thing I grabbed in Peter Obi's speech … Not falling for ANY other thing .. #ThePlatform
— Mr. JAG® (@jag_bros) October 1, 2016


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Casio Elegant Wristwatch (MTP-1314SG-1AV).
- Original Japan Movt. Casio Wristwatch
- 50-meter water resistance
- Date display at 3 o'clock
- Targeted Group: Men
- Watch Shape: Round
- Display Type: Analog
- 1 Year International Warranty.
Customers who bought this product also commonly purchased the following combination of items.
Regular Price:
Special Price


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LEURA BUNGALOW - Blue Mountains
House, Leura
Confirmation within 24hr
From $260 per night {{quote.pricing.message}} Total {{quote.pricing.price | format:'currency':'short'}} for
Min 2 - 4 nights stay
Compact but comfy two bedroom home with excellent lounge and cosy gas fire. Large, private backyard with mature trees. Large deck at rear overlooking garden. The shops and restaurants of Leura are only 200 metres away from this conveniently located cottage. Off street parking under a caport. Secure fences. Small pet friendly.
Plenty of cosy heating and electric blankets are supplied for those chilly winter nights.
Katoomba & Leura are the main locations for shopping while the world renowned Three Sisters Lookout and Information on bushwalks and local tourist attractions is located at Echo Point.
Bedroom 1 has Queen bed
Bedroom 2 has 2 single beds
Rating snapshot
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Feel free to send a message to the owner/manager if you have any specific needs, or if you require additional information before you can commit to a booking request.
Select request booking to access the quote calculator and to check availability.
Enter your check in and check out dates to see availability and a total price.
|Sun to Thurs ($ p/n avg.)
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|7 night stay
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|{{tariff.weekdayMinimumRate | format:'currency':'short'}} -
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The following dates have a special rate or exception applied. Please note any discounts applicable to these dates will still apply.
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p/n = per night, p/s = per stay, p/p = per person, p/np = per night and person. Ask the owner to arrange optional extras
Note: Pricing is subject to change, and a minimum stay period and other conditions may apply. You should confirm pricing with the property owner. Bookings paid through the Stayz online booking system incur a 2% Service Fee.
Prices listed based on 4 adults. Property has 3 beds and can sleep a maximum 4 people.
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Sometimes it's hard being right.
Back in 2010, before I realized there wasn't much money in writing about video games, I penned an opinion piece for The Escapist. The topic? Steam, and it's current and/or impending monopoly status.
My point, in essence, was that what people think of Steam and Valve right now is irrelevant because, once the platform dominates, it'll be free to disregard what's in the best interests of consumers and developers.There will be nothing stopping Valve from making bone headed moves out of ignorance, greed or stubborn idealism.


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BrickShooter Gameplay 1 iOS / Android
By: T Studio
Genre: Puzzle
Video Tips
Let's play BrickShooter! This is part 1 of my walkthrough guide for the iOS game, BrickShooter by T Studio UAB.
I will update this post with more tips and tricks, so please bookmark this page and keep on checking in!
If you have any questions, feel free to ask for extra help in the comments section.
Hit like if this helped you!
Visit BrickShooter walkthrough page for level videos, tutorials, cheats and more.
Gameplay Questions
Questions related to gameplay of BrickShooter iPhone game.


text:
2012 TOYOTA Avalon Sedan 4D
Use the SHIFT key to zoom in.
Use the CTRL key to zoom out.
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2016 CHEVROLET Impala LT Sedan 4D52K $16,999 View Details
2017 FORD Taurus Limited Sedan 4D25K $23,499 View Details
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2012 TOYOTA Avalon Sedan 4D
No-Haggle Price
Estimated payment:2 Adjust Pmt. Terms
Call Us
Visit Us
St. Louis, MO 63123-6937
- Moon Roof
- Daytime Running Lights
- Dual Power Seats
- Side Air Bags
- Power Steering
- Power Windows
- Dual Air Bags
- MP3 (Single Disc)
- Alloy Wheels
- Head Curtain Air Bags
- Stability Control
- Leather
- SiriusXM Satellite
- Backup Camera
- Power Door Locks
- AM/FM Stereo
- Air Conditioning
- Bluetooth Wireless
- Cruise Control
- Keyless Entry
- Traction Control
- Tilt & Telescoping Wheel
- ABS (4-Wheel)
- Remote keyless entry -inc: panic alarm illuminated entry trunk release
- Woodgrain style interior trim
- Illuminated entry w/fade-out exit system
- Leather-wrapped shift knob
- Anti-theft system w/engine immobilizer
- Rear passenger reading lamps
- (2) 12-volt aux pwr outlets
- Aluminum door scuff plates
- Digital clock
- 4-way pwr front passenger seat
- Adjustable headrests for all seating positions
- Auto-dimming rearview mirror -inc: backup camera monitor compass
- Pwr door locks w/anti-lockout feature
- Pwr trunk & fuel-filler door releases
- HD rear defogger w/timer
- Cruise control
- Front bucket seats w/active headrests
- 8-way pwr driver seat w/pwr lumbar
- Front seatback pockets
- Leather seat trim
- Dual sun visors w/illuminated visor vanity mirrors
- Front center console w/storage -inc: sliding armrest dual cup holders
- Overhead console w/front map lights & sunglasses storage
- Rear flat floor
- Tilt/telescoping steering wheel w/audio & climate controls
- Pwr windows -inc: auto up/down jam protection retained pwr
- Leather-wrapped steering wheel
- Dual-zone automatic climate control w/air filtration rear seat vents
- Projector-beam halogen headlamps
- Color-keyed bumpers
- Pwr tilt/slide moonroof -inc: sliding sunshade
- Integrated wide angle fog lamps
- Auto on/off headlamps
- 17 6-split-spoke machine-finished alloy wheels
- Washer-linked variable intermittent windshield wipers
- P215/55R17V93 all-season tires
- High Solar Energy-Absorbing (HSEA) glass
- Full size spare tire w/alloy wheel
- LED tail lamps
- Outboard front seatbelt pretensioners w/force limiters
- Front/rear crumple zones
- Front & rear side curtain airbags
- Internal trunk-release handle
- Head impact protection structure
- Vehicle stability control (VSC) w/off switch
- Daytime running lights
- Back up camera w/integrated rearview mirror display
- Child protector rear door locks
- Driver knee airbag
- 4-wheel anti-lock brake system (ABS)
- Side-impact door beams
- Traction control (TRAC)
- Driver & front passenger advanced airbags -inc: occupant sensor
- Electronic brakeforce distribution (EBD) w/brake assist (BA)
- Direct tire pressure monitor system
- Driver & front passenger seat-mounted side-impact airbags
- Energy-absorbing collapsible steering column
- Child restraint system w/rear seat lower anchors tether anchor brackets
- Variable-assist pwr rack & pinion steering
- Dual rear exhaust w/chrome-tipped outlets
- Pwr ventilated front/solid rear disc brakes
- Battery saver
- 3.5L DOHC EFI 24-valve V6 engine
- Front wheel drive
- MacPherson strut front suspension -inc: offset coil springs stabilizer bar
- Dual variable valve timing w/intelligence
Similar Vehicles
2016 CHEVROLET Impala LT Sedan 4D51,478 $16,999 View Details
2017 FORD Taurus Limited Sedan 4D24,002 $23,499 View Details
2012 TOYOTA Avalon Sedan 4D62,258 $15,499 View Details


text:
The wait is over because my favorite song off the "King of Queens" album finally gets a video Duro Timi!
"Effyzzie Music diva Yemi Alade is set to unlock her latest music visual offering for the track Duro Timi, off her successful debut album"King of Queens", on the 31st of July, 2015.
Behind the scenes footage from the shoot which took place in London has surfaced online courtesy Promoshin Tv; reportedly Ovié Étseyatsé serves as the visual's director and Taiye Aliyu the co-director. To watch the official music video when it premeires subcribe towww.youtube.com/YemiAladeVEVO
What to expect from the music video of the Sizzle Pro ballad.
Watch the "B-T-S" footage below."


text:
Product code: 11027
Despatched in 1-3 days.
To order, please email to email@example.com or phone us on +44(0)1923 296 780.
Almond Oil Organic An organic general purpose, light, cold-pressed, skin conditioning oil for all skin types, which helps prevent moisture loss from the skin. Its gentleness makes it a particularly useful oil to use with babies, children and sensitive or irritated skin in general. It has a delicate sweet smell obtained from the ripe seeds of the small sweet almond tree.
Prunus amygdalus dulcis (Almond) oil*+.*Organically produced ingredient. +Nut based ingredient. Made with 100% organically produced ingredients. This is a vegan product.
A gentle, skin conditioning oil, mild enough for sensitive skin.
Sign up for the latest news, offers and ideas.
eChemist.co.uk © 2017. All rights reserved.


text:
The second FOX 60-second TV spot of 'X-Men Origins: Wolverine' continues the previous spot and highlights on the brotherhood between Logan and Victor Creed.
Following the outing of the "Outcasts" TV spot on Sunday, February 15, the second of the three special 60-second TV spots for "X-Men Origins: Wolverine" has been premiered on FOX Monday, February 16. Continuing the story of young Logan briefly, this TV spot is entitled "Brothers" as it takes the focus on the relationship between Logan and Victor Creed.
This spot begins with a quick-paced glimpse of the events shown in the first TV spot. Then, it continues to show the bond Logan and Victor Creed establish during their early years when they are involved in one war after another. After a scene where the two are told that they are sentenced to death, snippets of the romantic relationship between Logan and Silver Fox take over.
In the end, it is displayed that Logan and Creed grow apart and they become each other's nemesis. After Logan figures out the reason behind Creed's evil deed to Fox, he seeks to avenge Fox's death and battles Creed. The last 60-second TV spot for "Wolverine" will come out Tuesday, February 17, during "American Idol".
Chronicling the events leading to "X-Men", "X-Men Origins: Wolverine" follows the story of Wolverine which centers on his epically violent and romantic past, his complex relationship with Victor Creed, and the ominous Weapon X program. Featuring Hugh Jackman, Liev Schreiber, Ryan Reynolds, Lynn Collins, Taylor Kitsch and will.i.am, the 20th Century Fox action fantasy film will be heading to U.S. theaters on May 1.
"X-Men Origins: Wolverine" - "Brothers" TV spot:


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For Individuals
What we do for you...
Our aim is to help you achieve what you want to achieve through your career. We make no assumptions about what that might be. We want to get to know you and learn about you and what you want. Continue Reading
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Retained Recruiting
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February 2014 - is there an octopus in there?(1000 Posts)
Okay I don't like to run out of things, even threads, so here's the new one.
Can't remember who described their baby kicking like an octopus but it's very true
We're nursery-less as well - have a couple of things still in their boxes (as of this morning that includes the pram - was worth the drive to Croydon to check what will fit in a corsa boot...) It doesn't need painting/papering so am saving it for some hardcore nesting in the post-xmas lull.
DH just looked at our energy use for the last year... it tripled in july and august...when i was off school... oops!!!
so i need to be good during maternity leave! no day time tv!
DH just looked at our energy use for the last year... it tripled in july and august...when i was off school... oops!!!
so i need to be good during maternity leave! no day time tv!
Eeeeek - I was thinking about that the other day Bare as ours is gonna shoot up when I'm home all day through winter. I guess I'll just have to wear lots of layers and sit in the dark!
Woo hoo DH says the flap jacks and "yummy" and "the best home made flapjacks" he's had. Phew! I will also be taking that last comment to read "the best flap jacks he has ever eaten full stop"
Message withdrawn at poster's request.
Message withdrawn at poster's request.
Ooooh a tip or the flapjacks which i read when i found the recipe on the original thread (couldn't be arsed finding it in our feb one), is to only add half the sugar if you use sweetened condensed milk. I did a double batch and used the whole tin, but halved the sugar and they are still super duper sweet.
Glad you're feeling better Champagne - you'll have to share your apple cake recipe - it sounds yummy
winterflowers I am seriously impressed you are still
managing to get in a bike! I can barely walk to the end of the road!
Just back from Asda where I purchased ingredients for a roast and the flapjacks as well as a pack of pampers new born and asda new born nappies! I know that's a bit premature and I'm a weirdo (DH was very embarrassed) but sod it - I walked past them and couldn't resist. I think I have left myself literally nothing else to get now so will have to invent things to make for the nursery instead
as a method of procrastinating from the work I'm still meant to be doing.
Had a ruddy good loud sing in the car on the way home to Frankie Goes to Hollywood (Power of love) and baby octopus went crazy. I'm taking it as an affirmation of my singing prowess rather than a protestation?
Oh and also discovered the left footwell of the car is under an inch of water. Good times.
Just checking in. We have had a lazy day so far. I am off to take DD to a party in a mo. baby has been going crazy this afternoon feels like he may break out of there.
My DH and DD are still not interested in seeing/feeling him move. Lucky I have my DS to humour me as he can easy rest his hand there for 10 mins getting really excited at the kicks. My DD just refuses she said "it's too weird and uncomfortable sitting there with my hand on your tummy. It's someone else's tummy that's just weird".
Well thanks DD it's only the tummy I grew you in for 9 horrendous pregnancy months. Gosh she will be a teen before I know it, very scary thought.
Ruey glad to hear there are other preggos in the village. Are you going to go to the Antenatal classes in January in the Baptist church?
not one actually I struggle with walking, can't manage much without my hip killing - but biking is fine so far! I can feel my bump more now though so think my cycling days are limited and I'm going to start having to take the tube
Thanks for the sugar tip misskatamari just checked my milk an it is sweetened already. Half the sugar means I can eat twice as much right?
Afternoon all
my octopus baby is having a squirm while I try and google how to fit a bath panel....
poor dc2 has nothing arranged for him/her apart from ds's old clothes, cot and pram! My dm has bought him/her a newborn cardigan though. I am really hoping that by 6 month-ish dc2 is a good sleeper and I can chuck them in with ds.
I just can't/don't want to think about getting organised for baby until after christmas as we are doing a fair amount with the house until then. I suppose I only really need to get nappies, breast pads, car seat & base and sling anyway so not much to worry about!
I am using disposables again as tried re-usables with ds and he was a mega wee-er and had to be changed every hour. sod that.
Amazon has a Tommie tippee digital video and sensor mat monitor for £100, has anyone got this and have opinions? It's 50% off! don't know whether to get or wait until January sales?
Also 74 pampers nappies, size 1 or 2 for £7.50 ish - is this good?
Well I'm behind on the baking homework and this weekend am baking my Christmas cake (Delia recipe) and the Bakerella cookies I linked to on the FB page. Possibility of flapjack making next weekend.
Our nursery is currently an empty room which we are very slowly painting. Tomorrow it's more wall paint then starting to rub down and gloss the white wood. 30th Nov the furniture arrives so need to do as much rubbing down before then as poss. Won't be finished completely until Jan though as we are having 1 wall of wallpaper and Dad is chief wallpaperer in our family, and he is booked up every weekend until new year.
Off out to a big girly meal later. Looking forward to it but am going to miss the vino. May have 1 cheeky glass but fear I will be getting lots of cat bum faces from all the ladies there who are mums. Perhaps best to stick to soft drinks.
The prospect of home baking tomorrow (plus a purchase of emergency mince pies earlier) has smoothed things over between DH and I after last night's teary argument. Who knew baking could be so medicinal?
26wks tomorrow - almost in 3rd trimester.... oh my god I'm having an actual baby .... <waddles off for a pre-girls night lie down>
I think all condensed milk is sweetened, no? I've never bought a non sweetened one, even if it's simply called condensed milk.
Had a lovely long walk this afternoon but feel utterly knackered now. We went and cancelled our gym membership too - don't see us using that with baby in tow.
Pram question: does anyone know anything about the mothercare my3?
Reviews are very mixed, but someone is selling it for £40 near me...
John Lewis advert - not wild about it.
Power of Love - YES.
Enjoy the flapjacks and cookies folks.
Just marking my place
Unsweetened condensed milk is unusual now apparently, the nearest you might find in supermarket is evaporated.
I've been reading through some local baby and toddler whats on magazines and am delighted to find that both the tommee tippee and nuby factory outlets are close by. Can stock up on those bits from there then.
We've got as far as discussing potential colour schemes for nursery but as it also involves repainting and carpeting another room for DS to move into. It's on our to do list.
Currently curled up with DS watching Fireman Sam
oh how intellectual my life is after a busy day at Beamish, bit tired now....
Marking my place, my octopus is a bit quiet today
Weve had a very busy day today. Went to our first nct sale. We're members and had no idea we could get in early! So we were stood at the end of the queue freezing like idiots for 20 mins and needless to say most of the good stuff had gone. Oh well, we'll know for next time!
Then we jetted off to Kiddicare, saw an uppababy with no box to be sold 'as seen' for £480 but dh was still unsure so we spent a couple of hours testing out other ones. We went back and it was reduced AGAIN to £399! We couldnt believe our luck, and dh is dead chuffed with the bargain, and I am sooo happy to have the pram I want!
Aw cam I love beamish! Went last year for the fireworks (although couldn't be talked into going this year as it was slippy and muddy last year and thought this year would be scary being preggo) and took the kiddies from school for our summer school. Not to mention mum now has a years pass so been quite a lot!
Tiny that's an amazing bargain! Well done! I have it in red - what colour did you get?
The red is lovely jazz we got cole blue which I'm very happy with. Think it will suit a girl as well if we have one next as its quite grey.
I just need a baby to put in it now
Will you get any if the accessories do you think?
That was our 2nd visit since Sept, we are going again in a couple of weeks for their Christmas event. It's good as we can let DS walk around and then pop him on tram when he is tired. I think we were both as tired as each other today!
Oh wow tiny what a bargain! I'm looking for an uppababy and would love to get that much off!
Can anyone share the bra measuring link again please?
eeyorish I know, I still can't believe it. Thats cheaper than we've seen on ebay too, hope there's nothing wrong with it!
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This study examined the safety of intracerebral inoculation of G207, an attenuated, replication-competent herpes simplex virus type 1 (HSV-1) recombinant, in nonhuman primates. Sixteen New World owl monkeys (Aotus nancymae [karyotype 1, formerly believed to be A. trivirgatus]), known for their exquisite susceptibility to HSV-1 infection, were evaluated. Thirteen underwent intracerebral inoculation with G207 at doses of 107 or 109 PFU, two were vehicle inoculated, and one served as an infected wild-type control and received 103 PFU of HSV-1 strain F. HSV-1 strain F caused rapid mortality and symptoms consistent with HSV encephalitis, including fever, hemiparesis, meningitis, and hemorrhage in the basal ganglia. One year after G207 inoculation, seven of the animals were alive and exhibited no evidence of clinical complications. Three deaths resulted from nonneurologic causes unrelated to HSV infection, and three animals were sacrificed for histopathologic examination. Two animals were reinoculated with G207 (107 PFU) at the same stereotactic coordinates 1 year after the initial G207 inoculation. These animals were alive and healthy 2 years after the second inoculation. Cerebral magnetic resonance imaging studies performed both before and after G207 inoculation failed to reveal radiographic evidence of HSV-related sequelae. Despite the lack of outwardly observable HSV pathology, measurable increases in serum anti-HSV titers were detected. Histopathological examination of multiple organ tissues found no evidence of HSV-induced histopathology or dissemination. We conclude that intracerebral inoculation of up to 109 PFU of G207, well above the efficacious dose in mouse tumor studies, is safe and therefore appropriate for human clinical trials.
At present, medical therapy cannot significantly alter the poor prognosis associated with glioblastoma multiforme, the most malignant form of human astrocytic brain tumors (11, 26, 31), making it an excellent target for new therapeutic approaches. Replication-competent, cytotoxic viral vectors offer such an approach, provided that their cytopathic effect is limited to neoplastic tissues. Vectors derived from herpes simplex virus (HSV) are particularly well suited to this approach because HSV infects a broad range of cell types and causes a cytotoxic, lytic infection, yet it can also exist in a latent state within neurons without causing damage (50). However, HSV infection of the central nervous system (CNS) causes encephalitis, with substantial morbidity (~50%) even with current antiviral therapy (35, 54, 64). In addition to HSV encephalitis, HSV keratoconjunctivis, esophagitis, pneumonitis (inflammation of the lungs), and hepatitis (inflammation of the liver) have been reported (9, 63). Therefore, it is very important that HSV vectors, especially replication-competent vectors, are nonpathogenic in normal tissue.
A large number of HSV genes affect pathogenicity (36, 43). γ34.5 (RL1), located in the long repeat region, enables viral replication in the CNS and is the major viral determinant of neuropathogenicity (8, 65). Mutations in γ34.5 result in decreases in the 50% lethal dose to >106 to 107 PFU after intracerebral injection (8, 30, 61). A number of HSV genes involved in nucleotide metabolism also affect neurovirulence, such as ICP6 (UL39), which encodes the large subunit of ribonucleotide reductase (5, 21, 67), and genes for thymidine kinase (UL23) (15, 17, 57), dUTPase (UL50) (46), uracil DNA glycosylase (UL2) (47), and DNA polymerase (UL30) (44). Attenuated, replication-competent HSV vectors containing mutations in these genes have been shown to effectively inhibit brain tumor growth in animal models (1, 3, 7, 22, 25, 33, 34, 39, 40, 48).
We constructed a second-generation HSV vector, termed G207, containing deletions of both γ34.5 loci (R3616 parent [8]) and an E. coli lacZ insertion that inactivates the ICP6 gene (hrR3 parent [16]) (40). These multiple mutations attenuate neurovirulence and make it unlikely that a pathogenic revertant could arise by recombination or by a second-site suppressor mutation (41). Other favorable properties of G207 are its easy detection due to the lacZ reporter gene, temperature sensitivity, and hypersensitivity to the antiviral drugs ganciclovir and acyclovir (40). As a result of its propensity for replicating in dividing cells, the cytotoxic effects of G207 are preferentially limited to neoplastic cells, resulting in efficacious treatment of established human brain tumors in athymic mice (40, 60, 68).
The use of potentially pathogenic, replication-competent viruses in humans for tumor therapy is dependent upon the demonstration that the mutant viruses will not cause additional disease. The New World owl monkey, Aotus nancymae (karyotype 1, formerly believed to be Aotus trivirgatus [18]), was selected as a nonhuman primate model to test the safety of G207 because of its exquisite sensitivity to HSV (20, 24, 38). Peripheral inoculation of 100 PFU of wild-type HSV-1 or -2 is lethal (37). Owl monkeys have previously been used to test the safety of live, attenuated HSV vaccine strains (37). Using this model, we have now demonstrated the safety of intracerebral inoculation of G207 at doses of up to 109 PFU.
HSV-1 strain F was provided by J. Chou and B. Roizman (University of Chicago) and G207 was constructed as previously described (40). Stocks of G207 were grown in African green monkey kidney (Vero) cells infected at a multiplicity of infection of 0.01 and cultured at 34°C in Dulbecco's minimal essential medium supplemented with 5% heat-inactivated fetal calf serum (HyClone). Virus was isolated from infected cells when the complete cytopathic effect was observed after a freeze-thaw/sonication regimen and low-speed centrifugation (2,000 × g for 10 min at 4°C) to remove cell debris. Virus was concentrated by high-speed centrifugation (45,000 × g for 150 min at 4°C) and resuspended in virus buffer (150 mM NaCl and 20 mM Tris, pH 7.5), for a final G207 titer of 6 × 109 PFU/ml. The titer of viral stocks was determined by a plaque assay on the Vero cells. Following each surgery, the titer of the inoculum was confirmed.
Sixteen New World primates (A. nancymae), 12 males and four females ranging in age from 1 to 6 years and in weight from 500 to 1,000 g, were obtained through the Veterinary Resources Program, National Center for Research Resources, National Institutes of Health (Poolesville, Md.). Seven of the animals were involved in prior experimental studies (T9205 and the others below), two of which had previously undergone splenectomy (T894 and T558). Four of the animals (T1122, T910805, T9307, and T1057) (Table (Table1)1) were briefly described in a previous publication (40). The animals were housed separately prior to and after inoculation. Animal procedures were approved by the Georgetown Animal Care and Use Committee and the Institutional Biosafety Committee.
The intracerebral inoculations and the surgical time frames for the 16 inoculated animals (13 with G207, 1 with strain F, and 2 with virus buffer) are listed in Table Table1.1. Monkeys were given general anesthesia (propofol drip of 50 to 100 mg/kg of body weight/h with saline in the lateral saphenous vein), and by using a Kopf stereotactic head frame, inoculations were made into the left frontal lobe, 2 mm anterior to the coronal suture and 7 mm lateral to the midline. After manual placement of a burr hole in the calvarium, a sample was stereotactically injected with a Hamilton syringe into the cortex at a depth of 5 mm. Ten microliters of diluted G207 (107 PFU), F, or virus buffer was injected over 5 min, or 180 μl of G207 (109 PFU) was injected over 40 min. Following injection, the burr hole was covered with bone wax and the incision was sutured. No perioperative antibiotics were used. Postoperatively, all animals underwent serial neurologic assessment, ear temperature measurement, and monitoring of food and water intake.
All animals were screened every 3 months (pre- and postoperatively) with a physical examination, a tuberculin test, and serologic analyses, including blood count with differential, protein measurement, chemistry, and lipase and amylase measurements. Additionally, anti-HSV-1 antibody testing was performed (MA BioServices, Inc., Rockville, Md.) on some blood samples with enzyme-linked immunosorbent assay (ELISA). Since one of the cardinal signs of HSV encephalitis is fever, aural tympanic body temperatures were measured twice daily for the first postoperative week, then daily for 3 weeks, and then at a further reduced frequency. The normal aural tympanic body temperature of the primates ranged from 96.9 to 101.5°F. Primates attempting to elude capture for these temperature measurements experienced a temperature elevation of approximately 2.5°F on average, as determined with a subcutaneously implanted temperature transponder (BioMedic Data Systems Inc., Maywood, N.J.).
High-resolution cerebral magnetic resonance imaging (MRI) studies were performed with a Vision 1.5-T MRI unit (Siemens, Erlangen, Germany). Each study consisted of precontrast T1-weighted images in the axial and sagittal planes (time to repeat [TR] = 500, time to echo [TE] = 20, excitations [E] = 4), proton density (TR = 2500, TE = 30, E = 4) and T2-weighted images in the sagittal plane (TR = 3500, TE = 39, E = 2), and postcontrast T1-weighted images in the axial and coronal planes after intravenous administration of gadodiamide (1 ml/kg; Omniscan; Nycomed Inc., Princeton, N.J.). The time frame for MRI imaging is indicated in Table Table11.
Animals were sacrificed by intravenous administration of sodium pentobarbital (40 to 60 mg/kg) followed by intracardiac perfusion with 4% paraformaldehyde. Following all deaths, due to euthanasia or otherwise, a complete necropsy was performed. Histologic samples were obtained from the peripheral organs: adrenal gland, heart, intestines, kidney, liver, lymph node, lung, muscle, pancreas, skin, spleen, stomach, and testes or ovaries. Occasionally, the adrenal glands were not found at the time of necropsy. In disseminated HSV disease, usually in neonates and immunocompromised individuals, numerous organs can be involved, including the adrenal glands, pancreas, intestine, spleen, stomach, kidneys, and muscle (9). From the CNS, samples were taken from the frontal, parietal, temporal, and occipital lobes; cerebellum; upper brain stem; medulla; and spinal cord. The injection site in the left frontal lobe was identified at the time of necropsy by the visualization of local scar tissue on the scalp and the burr hole in the skull, and tissue was isolated from the scalp, skull, and left frontal lobe. Specimens were embedded in paraffin, and 10-μm sections were obtained by using a microtome and then dehydrated, stained with hematoxylin and eosin, and coverslipped (29). Additional sections were immunohistochemically stained for HSV-1 antigens with rabbit anti-HSV-1 antibody (Dako) (4), followed by Vectastain indirect immunoperoxidase detection and then counterstained with hematoxylin. Histologic sections were evaluated by a board-certified neuropathologist (H.J.M.).
To test the safety of G207 and the extent of neurotoxicity associated with it, we performed stereotactic intracerebral inoculations in the left frontal lobe in three groups of animals: a single inoculation of 107 PFU of G207 in nine animals (group 1), a single inoculation of 109 PFU of G207 in two animals (group 2), and a second inoculation of 107 PFU of G207 1 year after an initial inoculation of 107 PFU in two animals (group 3) (Table (Table1).1). In the first group, one animal each was sacrificed at 3, 6, and 12 months for histopathological examination, three animals were alive and healthy more than 2.5 years after inoculation, and three animals died from causes unrelated to HSV. Of the latter deaths, one resulted from extended fasting in preparation for an MRI study (T894), one resulted from an anesthetic complication during surgery to remove an inguinal hematoma (T432), and one resulted from acute pancreatitis (T910805) attributed to natural disease because there was no histologic or immunohistochemical evidence of HSV infection in any of the organs examined, including the pancreas. At the time of necropsy, the injection site was notable in some animals while the brains looked otherwise normal (Fig. (Fig.1).1). Among the three sacrificed animals, neuropathologic examination revealed no abnormalities of the CNS, with the exceptions of sparsely distributed interstitial and/or perivascular inflammatory cells and gliosis at the injection site (Fig. (Fig.2).2). For many animals the injection site was not apparent in histologic sections. The peripheral organs also revealed no evidence of toxicity attributable to G207, and no HSV-immunoreactive cells were seen in any of the examined sections, including those from the injection site. The hearts and kidneys of several monkeys contained mild fibrosis and interstitial nephritis, respectively, a common finding in Aotus (62).
A large inoculation volume (180 μl) was required for group 2, the animals receiving a high dose of G207 (109 PFU). One of these animals (T413) had a tonic/clonic seizure 5 days postinjection and developed mild contralateral weakness, which resolved over 3 days. This animal remained healthy until it died 7 months after inoculation due to a ruptured aortic aneurysm. No histologic evidence of neural, systemic, or vascular HSV infection was found. The other animal (T558) experienced no adverse effects due to the surgery and remained healthy until sacrificed 20 months after injection. T558 had one of the lowest normal body temperatures (98.4 to 100.5°F).
In order to determine whether prior HSV infection might result in an enhanced inflammatory response or allergic encephalomyelitis, animals T442 and T348 were reinoculated with G207 1 year after the first inoculation at the same stereotactic coordinates. There was no evidence of any clinical disease or MRI-detectable changes in these animals and they were alive and healthy more than 2 years after the second inoculation.
To control for complications due to surgery and to provide a baseline for tissue histopathology, we stereotactically inoculated virus buffer into two animals, T421 and T357 (Table (Table1).1). T357 was euthanized 30 months after mock inoculation after becoming moribund due to acute cardiopulmonary failure, and T421 was alive and healthy more than 3 years after surgery.
To confirm the exquisite sensitivity of A. nancymae to HSV and to determine the symptoms of HSV encephalitis in this species, one animal (T1057) was inoculated with 103 PFU of strain F, a dose of the wild-type parental strain of G207 4 to 6 log units lower than that of G207. This animal exhibited signs of encephalitis, with a rising fever (103°F on day 3 and 105°F on day 4) and lethargy. On day 5, the animal exhibited hypothermia (97°F), right hemiparesis, and left pupillary enlargement and was euthanized. Histologic signs of HSV encephalitis included meningitis, with thickening of the meninges, subarachnoid hemorrhage, and inflammatory cell infiltrate in the underlying brain parenchyma (Fig. (Fig.3A);3A); hemorrhage within the basal ganglia (Fig. (Fig.3B)3B) and ventricles; and acute cerebritis, necrotic neurons, and Cowdry A nuclear inclusions (Fig. (Fig.3C).3C). Immunohistochemical staining for HSV-1 revealed numerous HSV-immunoreactive neurons in both frontal lobes (Fig. (Fig.3D),3D), ipsilateral amygdala, and arachnoid cells. Hemosiderin and erythrophagocytosis were seen in the spleen and in the liver and lymph nodes, respectively, consistent with this animal's involvement in a previous malaria study. The remaining organs were normal.
MRI has been shown to be a sensitive noninvasive test for identifying the tissue injury occurring in HSV encephalitis (12, 28, 53, 59). MRIs were obtained 10 days (Fig. (Fig.4A)4A) and 1 (Fig. (Fig.4B),4B), 6, 10 (Fig. (Fig.4C),4C), 11, and 12 months after an initial inoculation of 107 PFU of G207; 3 and 13 months after a second inoculation of 107 PFU of G207; and 6 months (Fig. (Fig.4D)4D) after an initial inoculation of 109 PFU of G207 (Table (Table1).1). Only subtle radiographic changes at the injection site and in the overlying calvarium, due to burr hole placement, could be identified (Fig. (Fig.4).4). These changes were attributed to the surgery itself since similar subtle findings are often observed after intracranial procedures in humans. No abnormal signal characteristics or contrast enhancements attributable to HSV toxicity were observed in dura or brain parenchyma at the injection site or throughout the rest of the brain.
Prior to inoculation, animals T9307, T348, T442, T558, T413, and T421 were found to be seronegative for anti-HSV-1 antibodies by ELISA. A single intracerebral injection of G207 (107 PFU) resulted in low serum anti-HSV titers that decreased over the course of a year, but T317 had a significantly elevated titer after 3 years (Fig. (Fig.5).5). A large increase in antibody titers occurred within 2 months of the second intracerebral injection of G207 in group 3 (1 year after the initial injection), which was still elevated 2 years later (T348 and T442) (Fig. (Fig.5).5). Even with this "booster" effect, no clinical, MRI, or pathological abnormalities were observed.
Replication-competent viral vectors that are cytotoxic have a number of attractive features for tumor therapy, such as the abilities to generate new infectious virus in situ while killing tumor cells and to spread within the tumor (49, 51). However, as a result of these properties, they are potentially more pathogenic than replication-defective viral vectors. When clinical trials with such viruses are being considered, it is imperative that adequate safeguards be engineered into the vector and that rigorous safety testing be performed. As an example of such a viral vector, we developed an attenuated, replication-competent HSV-1 vector, G207, as a therapeutic agent for brain tumors. G207 is derived from HSV-1 strain F, one of the least virulent laboratory strains (13). It contains deletions of both copies of the γ34.5 gene, the major viral determinant for neurovirulence (6, 8, 56, 58), and a lacZ insertion inactivating the ICP6 gene. ICP6 is required for efficient viral replication in nondividing cells (16, 45) and also is a determinant of neurovirulence (5, 21, 67). The presence of multiple mutations is important for safety, even with deletion mutants, because second-site suppressor mutations (41) or novel recombinants could arise through selective pressure during replication in the tumor or brain.
HSV has evolved elaborate mechanisms to survive in the nervous system, its natural reservoir in humans and the site where it causes the most serious disease. In humans, illness resulting from HSV can be manifested by a variety of syndromes, including disseminated virus; CNS infections; and exanthema localized to the eyes, skin, and mouth (9, 63). CNS infections, usually due to HSV-1, often cause a devastating and rapidly fatal encephalitis. Death occurs in approximately 70% of those who do not receive treatment (66). The signs and symptoms of HSV encephalitis include fever, mental status changes (altered consciousness and personality changes), headache, nausea, and focal neurological findings (i.e., seizures and hemiparesis) indicative of the infected brain area, usually the temporal lobes (9, 54, 66). In neonates, about half the infections involve encephalitis, alone or with disseminated disease, and death is often associated with brain stem involvement (55). Acyclovir is the treatment of choice. However, even when adequate antiviral treatment is rendered, approximately 20% of patients die and the majority of survivors suffer significant neurologic impairment (35, 54, 66). Since G207 is a derivative of HSV-1, it is important to demonstrate that intracerebral inoculation with G207 does not pose a potential health hazard.
A. nancymae is an excellent animal model for characterizing the pathogenesis of HSV. These nonhuman primates are extremely sensitive to HSV infection and disease (24, 38), similar to human neonates and immunocompromised patients (37). They develop clinical symptoms of HSV infection similar to those of humans. Aotus has a somewhat elevated and variable body temperature compared to humans, which might affect the pathogenicity of G207. However, strain F has a temperature sensitivity similar to that of G207 (27), and the animal inoculated with 103 PFU of strain F rapidly developed an encephalitis so severe that euthanasia was required within 5 days of inoculation. An examination of the brain tissues from this animal revealed typical histologic findings of HSV infection, including meningitis, inflammatory infiltrates, neuronal necrosis, Cowdry A intranuclear inclusions, and hemorrhage (24, 38). In contrast, a single intracerebral inoculation with 107 or 109 PFU of G207 produced no neurologic symptoms, and some animals were still alive and healthy 41 months after injection. One animal had a brief seizure 5 days after its inoculation with 109 PFU of G207; this could have been due to cortical irritation along the needle track, the location of the inoculation, the volume inoculated, or the virus. However, the symptoms were self-limiting and required no treatment, and no viral pathology was detected in the brain when it was examined 7 months after inoculation.
Noninvasive diagnostic tests for HSV encephalitis include electroencephalography, computerized tomography, single-photon emission-computed tomography, and MRI (14, 19, 42, 52). MRI is highly effective at detecting the changes in brain water content that accompany brain tissue inflammation and is particularly useful for detecting the early changes associated with HSV encephalitis (28, 53, 59). We obtained MRI scans from 10 days to 1 year following G207 inoculation, and no radiographic evidence of encephalitis was found.
All animals tested developed a detectable but equivocal serum anti-HSV antibody response after intracerebral inoculation of G207. The two animals that received a second G207 inoculation 1 year after the first developed a rapid boost in antibody titer that lasted for at least two more years. In humans experiencing a primary genital infection (HSV-1 or -2), anti-HSV serum antibodies detected by complement fixation, radioimmunoprecipitation, or ELISA are generally not detected in the acute phase of infection (within 1 to 2 weeks) but are present in the early convalescent phase (2 to 8 weeks) after the onset of symptoms (2, 23, 69). In a 9-month-old child that developed HSV encephalitis, neutralizing serum antibody was not detected on day 5 after disease onset but was detected on day 9, increasing to a maximum at days 14 and 26 and then decreasing to about half this level in 14 months (32). While intracerebral inoculation is not a reasonable approach for vaccination, these studies suggest that G207 may be a useful live, attenuated strain for HSV vaccination in the periphery.
These studies demonstrate that G207 can be inoculated safely into the brain at doses of up to 109 PFU, at least 6 log units higher than a lethal dose of wild-type HSV-1. Even animals with humoral immunity due to prior exposure to G207 experienced no adverse consequences, and neither demyelination nor other neurologic sequelae occurred following a repeat intracerebral inoculation. This extensive neural toxicity testing suggests that G207 should be safe for intracerebral use in humans.
This work was partially supported by a fellowship from the American Association of Neurological Surgeons (W.D.H. and F.F.) and a grant from the National Cancer Institute (NS 32677 to R.L.M.). S.D.R. and R.L.M. are consultants for NeuroVir, Inc., which has a license from Georgetown University for G207.
We thank Anu Iyer, Mary Jane Plym, Tina Wilson, Laura Rutter, and Michael Newsome for their technical assistance and the anonymous reviewers for their helpful comments.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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SWITZERLAND: GM reports good September in Europe but YTD results not so strong
General Motors boosted nine-month sales in Europe by 25,000 or 1.7% to 1,525,000, though market share remained around 9.5%.
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The Home Depot just launched some AWESOME new Weekend Workshops that are totally FREE but you gotta sign up fast HERE. Here's what you can expect:
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Luxury accommodation in a beautiful 18th century Cotswold stone house with original features providing oodles of character and charm.
Situated less than 50 yards from Broadway village centre, Cowley House has individually designed, stylish rooms furnished to a high standard. A scrumptious Cotswold breakfast sourced from the finest fresh, local ingredients is served in the relaxing surroundings of an oak beamed breakfast room. Ideally situated for touring the Cotswolds We have one room available that we allow dogs to stay in at a small charge of £5.00 per night, please inquire at the time of booking.
We only take 2 night bookings at weeknds and 3 night bookings at Bank Holidays, however it is always worth contacting us incase we do have a single night available.
Reach Broadway on A44 (Oxford-Evesham). In the village centre drive along the High Street until you see the the Village Green. Turn into the road adjacent to the Village Green, Church Street, signposted to Snowshill and Snowshill manor. Cowley House is the 3rd building on the right, opposite the Crown and Trumpet pub.
You can check in from 16:00. You need to check out by 11:00.


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Strawberry & Mascarpone Trifles With Riesling Syrup
Be the first to review
READY IN: 25mins
Recipe by Manami
Food & Wine Magazine, June 2007
See Discussion:
Ingredients Nutrition
- 1 cup dry riesling wine
- 1⁄2 cup sugar
- 1 tablespoon sugar
- 1⁄2 vanilla bean, halved lengthwise, seeds scraped
- 1 lb strawberry, hulled and sliced
- 1⁄2 cup mascarpone cheese
- 1⁄4 cup heavy cream
- 6 slices poundcake (1/2-inch-thick each slice cut into 4 triangles)
- 1 sprig mint (to garnish)
Directions See How It's Made
- In a small, heavy saucepan, combine the Riesling with 1/2 cup of the sugar and the vanilla bean and seeds.
- Bring to a boil over high heat, stirring, until the sugar dissolves.
- Continue to boil, undisturbed, until reduced to 1/2 cup, about 8 minutes.
- Let cool slightly.
- Put the strawberries in a bowl and strain the syrup over them.
- Use the vanilla bean to flavor your sugar.
- In a medium bowl, using an electric mixer, whip the mascarpone with the cream and the remaining 1 tablespoon of sugar until soft peaks form.
- Place 2 cake triangles in each of 6 dessert bowls and top with half of the strawberries.
- Repeat with the remaining cake and strawberries.
- Spoon any remaining syrup over each bowl, dollop on the mascarpone cream and serve.
- Garnish with a sprig of mint.


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The survival of a bee colony depends on the bee's ability to find flowers containing food. The bright color and sweet aroma of certain flowers acts as natural attractants for bees. Bees use a combination of eyesight and sense of smell to identify flowers with the pollen and nectar they need to survive.
Pollen is a bee's food source, and in order to eat, a bee must be able to locate flowers containing pollen. Additionally, finding flowers filled with nectar allows a bee to make honey, an important bee byproduct. According to Vilas Land and Water, honeybees and native bees serve as the earth's leading pollinators of plants, and this process only occurs after a bee has found and eaten from a plant.
Bees are able to see blue, green and violet. They also have the unique capacity to see ultraviolet light patterns, which are invisible to the human eye. Bees use the color patterns found in the petals of flowers and the ultra violet light to determine the presence of both pollen and nectar. If the ultraviolet light is not present, bees become disinterested in searching for flowers.
According to Bee Source, bees use scent to identify the specific sweet flowers that contain ample amounts of food. They also leave their scent on the flowers that they have already visited. When other bees detect the scent, they avoid this particular flower and land on another one. Bees can also deposit a slightly different scent on flowers that have an abundant amount of food, allowing fellow bees to visit and consume the rest of the food.
Scout bees forage for food and once found, the scouts will communicate the find to other bees in the hive by performing a tail-wagging dance. According to the website Polarization, scout bees carry the scent of the flowers on their body, and this coupled with the dance allows the other bees to locate the flowers. When dancing, the bee flies in a straight line to specify the direction where the food can be found. The rapidity at which the dance is repeated indicates the distance of the food from the hive.
Smog threat
Smog and exhaust obscure a bee's ability to smell, and increased pollutants in the air can make its search for flowers difficult or impossible. Without the aroma, bees are forced to rely on eyesight alone to locate flowers.
Related Searches
- Photo Credit bee image by david purday from Fotolia.com
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text: Jill Poyerd, NWS, is a contemporary realist whose award-winning work can be found in private collections both nationally and internationally. She has been featured in national publications, is the author of the portrait painting book Fearless Portraits, and is a signature member of several prestigious art societies, including the National Watercolor Society. Jill works in both watermedia and oil paints and has exhibited extensively throughout the Mid-Atlantic region as well as in national shows. In addition to her work as an artist, Jill is an active member of the arts community. She has curated, as well as judged, many multi-medium group shows, and is the founder and current head of the Fine Art Professionals of Northern Virginia. Additionally, she has produced a series of art appreciation videos aimed at enhancing the public's art experience.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Based on the answer received from Pamela Koslyn:
Since your spouse can argue he contributed to house payments, upkeep, etc., during the marriage and is entitled to some interest in in, you may want a pre-nuptual agreement to protect your property that he'd otherwise be entitled to.
To get the going rates are for family lawyers in San Francisco, make a few phone calls to lawyers there. For referrals to SF family lawyers, call your local bar associations or do internet searches.
Disclaimer: Please note that this answer does not constitute legal advice, and should not be relied on, since each state has different laws, each situation is fact specific, and it is impossible to evaluate a legal problem without a comprehensive consultation and review of all the facts and documents at issue. This answer does not create an attorney-client relationship.Ask a similar question
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text:
Ford is making the Kuga facelift a tad fancier by giving it a plush Vignale trim.
Introduced as a concept at the Geneva Motor Show, the Kuga Vignale is making the transition to a production model to join other posh Fords such as the Mondeo, S-MAX, and Edge. Just like the other Vignales, the new entry represents Ford's attempt to push the model upmarket by giving it a special exterior finish and more leather on the inside. It's worth mentioning all of these models are being hand-finished by "master craftspeople" at the company's Vignale Center located at the Valencia factory in Spain.
The production-ready Kuga Vignale is being shown in a pearlescent-metallic Vignale Milano Grigio paint matched on the inside with a hexagonal-quilted Cashmere leather exclusive to this version. It also gets a special look for the front grille like the rest of the Vignale models and comes with dark gloss-effect finishes noticeable on the skid plates, trunk trim, and on the door appliques.
Ford will sell the range-topping Kuga facelift with two engines, a 1.5-liter EcoBoost gasoline unit available in 150 hp & 182 hp versions and a 2.0-liter TDCi turbodiesel rated at 150 hp & 180 hp. Depending on selection, six-speed manual and automatic transmissions are available, along with an all-wheel-drive layout that can split torque up to 50:50 between the two axles in less than 20 milliseconds.
All Vignales come as standard with the SYNC 3 infotainment system featuring an eight-inch touchscreen display and working together with a premium sound system. The cars also get plenty of safety kit, including Lane Keeping Alert, Blind Spot Information System, Driver Alert, Lane Keeping Aid, and Traffic Sign Recognition.
The reason why Ford is rolling out more expensive Vignale editions of its models in Europe is because the company is enjoying high demand for the Titanium trim which up until the Vignale's introduction served as the flagship model. As a matter of fact, more than 80 percent of Kugas sold last year in U.K. were Titanium versions. That's why the Blue Oval company believes there's room for a fancier version with a higher price tag to match the upgrades. The Mondeo and S-MAX in the Vignale trim have been available for quite some time and will be joined before the year's end by the Edge and Kuga.
Source: Ford


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New Jersey Botanical Gardens and Arboretums
The popular Botanical Gardens and Arboretums
in New Jersey that display a wide variety of plants, shrubs, and trees that have been cultivated for scientific, educational, and ornamental purposes.
Some of the gardens and Arboretums include a reference library, a herbarium, and greenhouses.
North Jersey Gardens
Cora Hartshorn Arboretum and Bird Sanctuary
324 Forest Drive South,
Short Hills, NJ 07078
An historic woodlands garden and educational institution. They promote an understanding of the relationship between people and the environment through programs that integrate arts, sciences and the humanities. The Arboretum conducts four major activities: education, outreach, research, and zoological/horticultural display. The Arboretum provides services to local schools, community institutions and citizens of all ages.
Cross Estate Gardens
New Jersey Historical Garden Foundation
Old Jockey Hollow Road
Bernardsville, NJ 07924
The gardens are intended to offer visitors a view of historic trees and learn about their importance to native Americans and colonists. Located on the property of the New Jersey Brigade Unit of the Morristown National Historical Park, the gardens feature a variety of perennials, a wisteria-covered pergola, a mountain laurel allee, native plants, and large specimen trees. The gardens can be experienced as a self-guided walk. Hiking trails are also on the site and connect to trails in Jockey Hollow, Lewis Morris Park, and the Scherman-Hoffman Wildlife Sanctuary (New Jersey Audubon).
The Gardens are open from dawn to dusk and admission and parking are free.
Frelinghuysen Arboretum
53 East Hanover Ave
Morristown, NJ
(973) 326-7600
A 127-acre park that provides a beautiful setting for visitors to take a casual walk around its beautiful Colonial Revival mansion to stroll amongst the beautiful gardens, woodlands, shrubs, and meadows, to discover and learn about plants that are ideally to the soils and climate of Morris County. Self-guiding trail maps and information are provided.
Leonard J. Buck Garden
11 Layton Road
Far Hills, NJ 07931
908 234-2677
The Leonard J. Buck Garden is a nationally recognized rock garden.
Since the late 1930s when the garden was established, the garden covering a 29 acre wooded stream valley has grown to include a range of planted rock outcroppings and woodland gardens. Named after Leonard J. Buck, who created the garden on his his estate, it subsequently donated in 1976 by Helen Buck to the Somerset County Park Commission. Visitors to the Leonard J. Buck Garden can expect to discover an amazing variety of exotic rare rock garden plants, beautifully landscaped amongst rock formations. Visitors can wander the wooded trails that filled with wildflowers, ferns, and other shade plants. Below the Visitor Center, the F. Gordon Foster Fern Collection contains a shade garden of hardy ferns and perennials. The peak season of bloom is in spring, when delicate wildflowers, diminutive alpines, and colorful azaleas all compete for attention, however horticultural interest is abundant throughout the year.
New Jersey Botanical Garden
2 Morris Road
Ringwood, NJ 07456
Spend a couple of hours wandering through the 96 acre gardens with over 400 varieties of lilac. Take a casual stroll though the woodland paths of magnolia walk and crab apples. The gardens contain mostly mostly annuals and as a result return visitors will experience a change throughout the seasons and from past years. There are also attractive fawns and small "Four Seasons" statues anchoring the ovals in the corners. Stop by for a visit at the magnificent Tudor-style manor house. . Admission is free.
Presby Memorial Iris Gardens
474 Upper Mountain Ave
Upper Montclair, NJ 07043
This living museum, listed on the State and National Registers of Historic Sites, offers a spectacular display of thousands of iris varieties to visitors from all over the world. Blooming season runs from mid-may through June
Reeves-Reed Arboretum and Gardens
165 Hobart Ave.
Summit, NJ
(908) 273-8787
The arboretum is attractive for visitors who are interested in experiencing and learning more about woodlands and gardens and to leave with the added knowledge of how they can become better stewards of nature and the environment. The site covers 13 acres of landscaped lawns, gardens and woodlands. It includes 5 1/2 acres of formal gardens. The gardens represent design trends of the early 20th century. Recently they have undergone restoration of the historic Wisner House, the Azalea Garden, and the Rock Garden. They also have a variety of children's educational programs and can host children's birthday parties.
Van Vleck House & Gardens
21 Van Vleck Street
Montclair, NJ 07042
Discover the beauty of the historic house and gardens on a 6 acres with over 400 varieties of trees and shrubs. The Van Vleck estate and gardens is an excellent example of the large estates built in this New York City suburb during the late 1800s.They also offer a variety of educational programs for adults and children Open daily, 9am to 5pm. Admission is Free
Willowwood Arboretum
300 Long View Road
Far Hills, NJ
(973) 326-7600
130 acres of rolling farm land, has about 2,100 kinds of native and exotic plants, many of them are rare. In addition to the formal gardens near the residence and undisturbed forest, historic collections include oak, maple, willow, magnolia, lilac, cherry, fir, pine, a superb specimen of Dawn Redwood (Metasequoia) now more than 98' tall, masses of ferns and handsome stands of field and forest wild flowers. open free to the public daily, 365 days yearly from dawn to dusk. Visitors are invited to enjoy the gardens Spring through Fall. During Winter, the Ornamentals Collection offers evergreen and deciduous plants featuring interesting fruit, bark or branching habit.
Central Jersey Gardens
Deep Cut Gardens
152 Red Hill Road
Middletown, NJ 07748
(732) 671-6050
Deep Cut Gardens, with over 54 acres of gardens and greenhouses, is an ideal place for the home gardener to enjoy the huge variety of native plants through the seasons. One of the sections features renovated Parterre with 52 varieties of roses with over 180 bushes. The gardens can be enjoyed by taking a casual walking tour or stopping by visitors center and the reference library to speak to one of the horticultural specialists.
Grounds For Sculpture
18 Fairgrounds Road
Hamilton, New Jersey 08619
(609) 586-0616
The Grounds For Sculpture is a 35-acre park that attracts over 100,000 visitors each year to enjoy the beautiful gardens, the outdoor permanent sculpture collection, indoor seasonal exhibitions, and to learn about contemporary sculpture through a variety of educational programs including workshops for adults and children, artist residencies and lectures, tours for adults, schoolchildren, toddlers, as well as touch tours for the blind..
Rutgers Gardens
Rutgers, The State University of New Jersey
112 Ryders Lane
New Brunswick, NJ 08901
Made up of a collection of specialty gardens geared to promoting and providing accurate information about the art of horticulture and the relationship between plants, human health and nutrition in the designed, as well as in the natural landscape. It includes:
Donald B. Lacey Display Garden - One of the most unusual and colorful displays annuals, tropicals, herbs and vegetables in NJ.
The Roy H. DeBoer Evergreen Garden - The evergreens are grouped by genus around the great sunken lawn, with a large weeping white pine serving as the focal point.
The Ella Quimby Water Conservation Terrace Gardens - A series of terraces demonstrating the sustainment of drought tolerant plants.
American Hollies - Displays an unusual collection of native evergreens.
Shrub Collection - Features the oldest collection of lilacs, both hybrids and species that were originally planted in 1927.
Rain Garden - Displays attractive and environmentally sensitive additions to residential, commercial and municipal properties.
Rhododendron and Azalea Garden - This garden was designed as a garden community integrating small trees with a variety of shrubs --- emphasis is on Rhododendrons and ground covers.
They also offer children's programs including group field trips, summer camp, and self guided tours. Open 365 days a year. Admission is free.
Sayen Park Botanical Garden
155 Hughes Drive
Hamilton Square
Hamilton Township, NJ
(609) 890-3874
Also known as Sayen House and Gardens, this 30 acre botanical garden is a municipal park with more than 1,000 azaleas, nearly 500 rhododendrons, and more than 250,000 flowering bulbs for spring display. The garden also is beautifully arranged with ponds, bridges, gazebos, and walking trails. The Gardens are at their peak in the spring when they have their annual Azalea Festival each Mother's Day, during which Sayen House is open to the public from 10AM to 4PM. Held Rain or Shine. The Sayen House can be rented by both Township and non-residents for private functions like wedding receptions, fund raisers, and other events
South Jersey Gardens
Camden Children's Garden
3 Riverside Drive
Camden, NJ 08103
This 4 acre indoor and outdoor center is enjoyed by both children and families. Here children can discover and explore the natural world. The garden provides horticultural experiences for creative and imaginative play. The Garden includes three indoor attractions and other outdoor exhibits and activities.
Leaming's Run Gardens
1845 Route 9 North
Cape May Court House, NJ 08210
(609) 465-5871
Leaming's Run Gardens is the ideal place to observe a variety of plant, insect, and animal life in a natural environment. Their ponds are teeming with fish, eels, frogs, and turtles. Rare native plants and mushrooms grow beneath the shade of centuries old oaks, hollies, and pines along with hundreds of lush cinnamon ferns. Butterflies and dragonflies are here in abundance. Hummingbirds make the gardens their temporary home in August. A tour of Leaming's Run holds delightful surprises for nature lovers of all ages.
Other New Jersey Resources
Plant and Wildlife
Habitat Guide
Discover the popular New Jersey plant and wildlife habitat refuges, sanctuaries, observatories and education centers.
Bird Watching Centers
The top bird watching activity centers and wildlife refuges in New Jersey that offer endless opportunities for bird watchers
Top Seasonal Things To Do
A Monthly Calendar of the Popular Seasonal Activities. A resource for making advance plans for experiencing a bit of New Jersey
New Jersey
Festivals celebrate arts, film, music, food and history, and more They each have something different to offer.


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Sat., Nov. 28, 2009, 8:11 p.m.
Things I am thankful for…
Good evening, Netizens...
After some prolonged introspection, a bit of meditation and some considerable prayer, I have belatedly come up with the things for which I am most-thankful in 2009. They are presented in no particular order, but are submitted more for the sake of clarity than anything else.
I am always and forever thankful for my wife, without whose stern guidance, gentle reminders, seductive mind and tremendous insight into what it means to be a woman in modern society I could easily become a pompous, uninformed and highly-opinionated ass. No, she did not bribe me to make this statement, for it is a statement of historically-provable fact.
I have been and still am thankful for the rich cornucopia of friends and loved ones who constantly render me guidance, allegiance and wisdom. My attempts at acumen and my purported intelligence would be a wasted affair were it not for those to whom I listen most-closely, whose opinions and ideas help shape me, give me focus and more often than not set me on the right track.
I am and will continue to be an unapologetic American, thankful for my heritage and hopeful for our nation's future. We, as a nation, have screwed up royally throughout history, for we have totally ignored the lessons of history at times. Yet despite all our dimples and warts we still stand tall as one of the greatest nations in the world. Our two greatest freedoms, freedom of speech and freedom of the press still stand tall and those two gifts of history few can equal.
Despite numerous brushes with death in all its permutations, and despite the fact I soon will be turning 64 years of age, I am thankful my health remains about what one could hope for from a sinner who has pushed the envelope of life about as far as one could while still remaining on his feet.
Having said that, perhaps I am thankful for the gifts of history most of all. I have seen television in the day of its infancy when it was awe-inspiring at times and even funny; it has been transformed into a wasteland of laugh tracks. I have seen computers as big as a house owned by mega-corporations change over time to where well-kept homes all have the power of the Internet and let it become as a play land for dolts. More sadly perhaps I have seen the ancient and spacious beauty of our land transformed where beauteous ancient orchards once stood, where a human could stand in the evening mist among the aroma of freshly-budding trees, to where only tract homes now exist. I possess all this in my memory's store and more.
What are you most thankful for?
You must be logged in to post comments. Please log in here or click the comment box below for options.comments powered by Disqus


text:
Canterbury England Showerproof Pullover Jacket for Men in Navy
Coes ID: G09004NVYnow £45.00 was £59.99
Style Notes
Protect yourself from pesky showers during outdoor training in this pull-on showerproof jacket, constructed from the best quality materials, and branded with the iconic English rose crest to show your support
Official England Rugby 2015-16 product Pullover jacket with an adjustable hood Contrast chest panel in Red with White stripe detail Navy exposed quarter-zip fastening Red rose crest, CCC logo and sponsor logo embroidered on the chest Hood with adjustable cord and toggles Pull cords at collar for easy hood adjustment Long sleeves with elasticated cuffs Zipped hand warmer pockets Secret pouch pocket below flap that runs across the body below the chest Hood and body fully lined in red mesh Sleeves lined in Red nylon Large sponsor logo on the centre back in White Curved back hem Shell & Lining: 100% Polyester Machine wash at 40 C – Wash with similar colours – Do not use bleach or fabric softeners – Tumble dry on low heat – Cool iron on reverse, avoid prints – Do not dry clean Also available: Canterbury England Presentation Jacket in Red, padded and quilted, featuring water repellent Vaposhield fabric technology Take a look at our full range of Canterbury England Clothing for Men & Kids, including Rugby World Cup 2015 and new season Jerseys
Product Delivery
Postage and packaging charges are as follows:
UK (including Channel Islands) – Standard Delivery is Free on orders over £50 & £2.50 on orders below £50. Express Delivery is Free on orders over £100 or £5 for orders below £100.
General Returns Policy
Because we offer free delivery to UK addresses and minimal postage charges to other destinations, we are unable to supply a free return option, unless goods are defective, or we have made an error in dispatch.
For any further information please visit our Returns page.
Any Questions? - Either contact us via email firstname.lastname@example.com, or telephone us on 01473 256061 between 9 am - 6 pm Tuesday to Saturday
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Canterbury England Home Classic Long Sleeve Rugby Jersey Shirt for Men in White - NEW £50.00 was £59.99
Canterbury British & Irish Lions Vapodri Classic Long Sleeve Jersey for Men in Red £50.00 was £64.99


text:
We help you search for a Withernsea bagpipes tutor. Bagpipes lessons are an excellent way to start a fun new hobby, pick up a new skill and gain confidence in bagpipes. Please use our service to search for Withernsea bagpipes teachers and determine which suits your requirements so you can begin your bagpipes tuition in Withernsea straight away!
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If you are a bagpipes tutor wishing to offer your bagpipes lessons in Withernsea or throughout the UK, please register with First Tutors: Music or learn about us here. Becoming a Withernsea bagpipes tutor is a great way to re-affirm your own skills by providing bagpipes lessons while assisting others, all in the Withernsea area!