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I will be going to Vietnam before the summer. I have no itinerary so I need help!!! Any suggestions?
I will be going to Vietnam before the summer. I have no itinerary so I need help!!! Any suggestions?
Can you make suggestions for tour companies??
vietnam is a great country to travel in. i spent 1 month backpacking there in august 08. as i was travel on my own i cant give any advice on tour companies....however i would def recommend independent travel as you have more freedom. i arrived in ho chi minh (saigon) late on my first night not really having an idea where/what i wanted to see. if you are any way socialable you will have no problems meeting other people. remember there will be many solo backpackers all looking to meet travel partners. Most backpackers in vietnam either start in hanoi and travel south or start in saigon and travel north. as far as i know there is only 1 backpacker style hostel in each city ....yellow house in saigon and hanoi backpackers in hanoi. as there are dorms in these it will be easier to meet people. all most all other accomadation in vietnam will be just hotels/guesthouses.
as vietnam is very popular with backpackers the tourist bus service between towns and cities is very good. must see places and trips are
2/3 day trip on the mekong delta.....try book a homestay for 1 night ...depart from saigon
day trip to the cu chi tunnels - depart from saigon
dalat - town in the mountains 3/4 hours north of saigon - a good base to go on an easy rider motor bike tour of the mountains/countryside
na trang - one of the best known beach resorts and party city
hoi an- one of my favourite places ive been in the world - fanastic relaxed old town famous for tailoring
halong bay - world heritage site 2 hours north of hanoi.....can look spectacular but is over touristy and can look polluted....you can book 3/5 day trips with overnight on a boat and overnight on cat ba island. be very careful who you book with....when we did this trip there was no organisation and we didnt get to do all we paid for....best advice is to ask people who have just done the trip who they recommend
sapa - mountain town in the north west of country not too far from chinese border.....great place to go on 2/3 day treks
in general vietnam is a very cheap country to travel in...... you can get decent rooms in guesthouses from $ 8 a night ......fantastic meals from $3/4 and bottles of beer from $1
hope this helps
It all depends on how much time you have and your interests. Most start in HaNoi or HCMC. Then head for the other city. This assumes you have the 2-3 weeks to travel the length of VN. If you only have a week or less, then you need to tell us where you arrive in VN. Your interests: hit the beach, visit the historic & cultural spots, get off the main track, motorcycle tour, diving, etc. Then members can help with your decision.
You basically have 3 choices of transport. You can fly the major legs if time is running short. Look at Jetstar Air and VN Airlines if thinking of flying inside VN. Take the train. Not a bad choice for overnight legs, say HaNoi to Hue. Safer, more comfortable than the open tour bus, more expensive. Or make use of the open tour bus system that runs between HAN &HCMC. Much cheaper than the train, more flexible scheduling, not as safe because of the road traffic in VN. I have used the open tour 5 times when in VN. I prefer the bus system, but I do admit it is not a s safe as train travel. Your choice.
I have heaps of VN photos in my gallery that may help with your decision. My blog covers my last trip to VN. Send me a PM if you have questions on VN. Good luck with your planning.
hi,vegamike is expert in Vietnam so he gave you alot of useful information but I just want to add some:
First you should tell us how many days you want to travel?
And your question is about What is MUST do in vietnam?you mean, everything action not just visit destination alone, right?
I think you should visit Hanoi, capital of Vietnam because this year we will celebrate 1000 years anniversary.
And then move to Halong Bay, world Heritage by UNESCO 2 times, and we are voting for world wonder.
Sapa, romantic place
If you still have time, you can visit Perfume Pagoda, Hoa Lu - Tam Coc.......
If you need more information, please tell me.
This information is about North of Vietnam
thanks a lot vegasmike6!!! the tour you suggested is exactly what i'm looking for. would you recommend the tour for someone that is backpacking alone?
I doubt you will alone for long. You are bound to meet others heading the same way you are. You will able to hit each city with new friends you meet on the open tour bus. Then you can tour DaLat, Nha Trang, Hoi An, Hue, HaNoi with your new friends. Plus have others to dine with and then hit the nightspots. Don't worry, you will have a great time touring VN.


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subset: commoncrawl


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This piece fits into a bedroom for my guests spending time in the villages. There isn't a guest that can't relate this picture to growing up spending time at their favorite stream or lake. The wonderful memories it brings back.
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text: Barcelona vs Malaga Prediction, Betting Tips and Preview Without doubts Barcelona are still one of the best teams in the world. However unlike the last season when they were undisputed, this season, even though with good results, many oscillations in their play can be noticed. They are currently at the ...Read More »


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Dead man talking
yes the story is about him, not about the database where this information is stored. Information on every single American citizen.
And, it is leading to much more dredible sources regarding what is going on stepping forward.
The best expose on PRISM now comes from the 40 year career NSA employee, William Benny, who became the director of Intelligence there under Geroge W. Bush. He has gone public since Snowden and detailed the full capabilities of PRISM and what the NSA was doing.
Former Director of NSA Intelligence reveals the full extent of PRISM capabilities. MUST SEE!
I don't understand why Cheney, for example, is so eager to call this guy a traitor.
All he released is "metadata": information about the information.
Any decent spy from another country would already behave as if every phone was bugged, wouldn't they?
Hell the Mafia has assumed that since 1930 or so. That's why they meet in person at coffeeshops, etc.
So the only thing different now, is that the innocent millions of Americans now KNOW they're being watched.
Hardly a traitorous act, it seems to me.
wierd, we have the left claiming he was a highly skilled hacker, whiel the right liek bolton, and rove and others claiming he was a no talent unsophisticated traitor/loser
Seems to me BOTH sides want to discredit him- perhaps they are scared he's got soemthign on them too?
Makes me wonder what the REAL story behind the Newt Gingrich cell phone call was:
Just so happened to hear it on a scanner as they were following him?
In light of all this new information I kind of doubt that story now.
"All I can say right now is the US Government is not going to be able to cover this up by jailing or murdering me,"
Holy crap! Is Snowden going to OUT 0BAMA? LOL! SURPRISE, his birth certificate is FAKE, his REAL parents aren't who we think they are, etc.. LOL!!! I would LOVE this. America rejoice, Hallelujah!
From the horses' mouths. http://www.usatoday.com/story/news/politics/2013/06/16/snowden-whistleblower-nsa-officials-roundtable/2428809/
"I dont understand why Cheney, for example, is so eager to call this guy a traitor."
Exposing what we can do makes our enemies aware of what we can do.
He never had access to dossier type information.
That just is not how information is gathered or stored.
Information resides on disparate dbases , in various forms and on various OS'.
Chinese Admiral Visits Coalition Warship
Chinese, U.S. Sailors Meet, Make Friends
China Set To Grab UAV Market While US Restricts Sales
UFO War: Chinese and US Navy off San Francisco
U.S., Chinese Navies Complete SAREX Together
Chinese Navy Vessels Visit San Diego
Lies of Omission


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Fencing is a skill that requires a keen eye and a precise hand, exactly like do-it-yourself Lasik and strobe-light Jenga. Hone a time-honored and extremely pointy tradition with today's Groupon: for $49, you get a seven-week introductory fencing course (up to a $170 value) at Worcester Fencing Club.
The Worcester Fencing Club trains fledgling foil-wielders in the mechanics of fencing with the seven-week introductory foil class. Coulé cadets learn the fundamentals of fencing, including basic footwork, attacks, parries, and how to riposte with steel when words fail to penetrate your opponent's defenses. Groupon holders age 7–11 will be enrolled in the under 12s class, which covers the same concepts in an environment focused on fun and sportsmanship. Classes provide participants with all the necessary equipment and meet once a week. Check online to see when each class is scheduled. Though each student must normally purchase a USFA membership, that requirement is waived for Groupon holders.
Worcester Fencing Club
Perhaps as a tribute to the timeless nature of the sword, the Worcester Fencing Club began as a small class held at the Higgins Armory Museum, a collection of arms and armor from medieval Europe and beyond. There, Doug Jacobs—a United States Fencing Association–certified instructor—began imparting his knowledge to a handful of students, giving them a small taste of the age-old sport that, over the years, had become unfairly associated with bullies popping balloons in the streets. Still, many of his students wished to extend their training, and—upon a suggestion of the mother of some of his students—Doug expanded his academy in 1998, forming the Worcester Fencing Club. Today, the school continues to draw fresh blood, introducing students of all ages and experience levels to modern- and Olympic-style fencing in classes still often taught by Doug himself.


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It seems that the European carriers got pretty stirred up by Apple's intent to get even more influential, solder a SIM card into the next iPhone, and allow people to flash it for use with any carrier they want via a simple app download. First, it was threatening to cut subsidies, and, rumor has it, actually diminishing the grand total they dole out to Apple for each iPhone, as well as taking the Apple promos off their home pages in a short-lived retaliation.
Then the European telcos obviously sat down, thought long and hard where this smartphone craze that makes the phone more important for users than the carrier will lead them to, and concluded that they are at the losing side of the equation. Therefore, France Telecom, Telecom Italia, Telefonica and Vodafone, are now demanding payments from Google, Apple and Facebook, among others, for the fact that they are generating too much traffic on their wimpy networks, and force them to invest in upgrading, or lose customers. It is basically the same guys that threatened to cut the iPhone's subsidies, if Steve Jobs makes them just "dumb pipes" for zeros and ones flowing to his superphone and "magical" tablet. Only T-Mobile is missing from the gang involved in the latest intimidation effort, but we are sure they will gladly take the money too.
AT&T and Verizon's CEOs have made comments before that they need to extract money from popular web services simply because they are popular, otherwise they will have to make do with the role of the aforementioned "dumb pipes". It didn't work then, it probably won't work now, but the net neutrality rules in the EU are stricter and encourage more competition among sites, so we'll see how this pans out. Basically Google, Apple, Facebook and the rest, can just say - "If you want money from us because we have invented services everybody wants, how about we share some of the monthly subscription fee people are paying you for your cable broadband or wireless, isn't that what's supposed to ensure your profits? Get a grip!".
source: Arstechnica & Barron's


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At the mall today i was standing cute outside a clothing store when a group of black dudes come up to me to chat me up. One of them stayed to chat it up.
It was fine at first, laughing and all until he asked for number, i told him i was maxed out in data storage & he continued to try until i told him that i dont date black men, only Latino & maybe white men,
There was this death look in his face & he called me a fuckin beaner cracker lover lol.
Not trying to sound racist but usually date my own race and I've dated white men because for me they are the closest thing to Latinos..
I've rejected many many men, not just black men. And i have loving black friends on Instagram..
There are many many other hot latinas you can try with, no reason to get angry at me.
This is 3rd time its happen to me but usually in social media :x
Most Helpful Guy
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My boyfriend is Mexican and he gets more hate from blacks for dating me than he gets from white men..62|40|0
Why? You aren't that pretty? Do black guys like you?
Yess black guys love me but i only like to be friends with them.
I dont know why black men are so jealous of my boyfriend


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Shema Kolainu – Hear Our Voices hosted a workshop presented by Dr. Stephen Shore this week. Dr. Shore is an Assistant Professor at Adelphi University and has published several books and chapters on autism including his personal experiences.
The workshop featured an introduction by Dr. Joshua Weinstein, CEO & Founder of ICare4Autism and Shema Kolainu – Hear Our Voices. He spoke about ICare4Autism's Autism Workforce Initiative which will be the first of its kind. The initiative will be an integral component of ICare4Autism's Global Autism Center for Research and Education in Jerusalem.
It will encompass workforce entry services providing high school students with autism with the opportunity to discover their interests and abilities by participating in a variety of vocational experiences, and works with students and their families to develop realistic transition plans when preparing to leave school and enter the workforce.
There will be vocational and employment services ranging for the semi-skilled, placing individuals in (or work as subcontractors on) jobs performing tasks such as light assembly, packaging, recycling, collating, lawn and garden work, etc. There will also be the placement for the high functioning placing individuals in jobs that build off their existing strengths and personality traits in such areas as computer programming, maintenance and operation of machines and equipment, laboratory technician, animal training and care, horticulture, handicrafts, photography, etc.
In recognition to the large number of opportunities in the technology sector and the unique skills that persons with Asperger's possess there will be a special targeted program to place persons with Asperger's Syndrome in technology sector jobs.
Dr. Weinstein also discussed ICare4Autism's International Autism Conference scheduled for August this year and those in attendance were lucky enough to receive a special discount on registration for the conference.
Dr. Stephen Shore then took the floor, speaking to a full house about employment opportunities for people with Autism. Even those individuals with ASD who achieved post secondary education or have highly developed skill areas often have difficulty selling themselves in job interviews and maintaining working relationships on the job. Drawing on his personal and professional experiences as an adult living with Autism, Dr. Shore shared the strategies he has used successfully to find and secure employment and meet the expectations of employers for people throughout the autism spectrum.
Dr. Shore reiterated the point that when looking for employment, those with autism should focus on their strengths and what could make them uniquely employable given special talents or interests.
The next workshop at Shema Kolainu – Hear Our Voices, The Road to Independence, is on the 28th of March and will cover issues such as toilet training, self care skills and pre-vocational skills. Click here to see the full workshop schedule.


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Quote:huh?are you talking about reacting without conscious thought? Wouldn't training for ANY real-time physical skill have that goal? from playing video games to piloting a fighter jet, ping-pong or sparing.
Quote: So, if I am reading you correctly you are saying that you know you will hit them right as or before you swing?
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I love getting numbers, my problem is when should I call. I hear a lotta diff techniques! If I get one on sat, sun I'm hungover and chillen piecing together what happen on sat night! Monday is a bad day for everyone and by tues I feel awkward like hey I'm the dude from sat uhhhhh! How long is too long? Too sooon etc.
Most Helpful Girl
Who cares about stupid rules and games?! I've always found it so silly to wait a certain amount of days just because it's what people believe it's what should be done. If I give you my number sat and you wait till wed to call. Well, by that then I will have moved on, figured you really weren't interested and when I get your call, I'll just think I'm an after thought, someone rejected you before me so now you call.
The only rule anyone should follow when it comes to calling is:
Call when you WANT to. Depends on how interested you are in the girl. If you really are interested in her, stop the silly rule game and just call her. I personally love it when a guy (if I'm into him) calls me the next day, shows real interest. But that's just me. Do what YOU want to do, not what silly society says.21|10|0


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Hyperlink in my auto responder gets automatically deletedAsked by Jaclynn on February 14, 2017 at 10:24 PM
Anytime I click on the hyperlink in my auto responder it automatically deletes the URL link I put in there prior. So even if I only want to update the Text to Display it automatically defaults to empty fields.
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You can highlight the text which has the link in it and then select the chain icon. This will allow you to edit the text without removing the actual link
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|Jack Rowe
|First appearance
|27th December 1978
|Number of appearances
|Played by
|William Tarmey
Jack Rowe was a friend of Dave Barnes. Dave was looking for Ken Barlow, angry and jealous of the reading and writing lessons that Ken was giving to his illiterate wife Karen and took Jack to the Rovers so that he could point him out to him. After a wait of some time, Ken came in from a party at 11 Coronation Street and, after Jack's identification, approached Ken, telling him not to mess about with his missus. He told Jack that Ken was gutless and knew what would becoming to him, should he continue to see Karen.
- This was William Tarmey's second speaking role in "Coronation Street", having played an unnamed Darts Player the previous year. Eleven months after this part he would go on to play his most iconic and long-running role - Jack Duckworth.


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DetailsWhat a convenient way to eat or drink on your couch! This beautiful natural reclaimed wood-look finished hollow-core accent table offers sufficient space for you to place your snacks, drinks and even meals. A large drawer provides hidden storage for magazines, mobile devices and remote controls. Its chromed metal base provides sturdy support along with a fashionable flair that will suit any decor.
- Additional Information
Additional Information
SKU 26700528 MPN I 3204 GTIN UPC 021032286477 Brand Monarch Specialties Collection N/A Assemble Length N/A Assemble Width N/A Assemble Height 24 Assembly Required Yes Material Metal Finish Chrome Styles Contemporary Shipping Time 1-2 Weeks Free Shipping Yes
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New York based veteran independent film distributor FIRST RUN FEATURES has acquired all rights for Stefan Haupt´s SAGRADA – THE MYSTERY OF CREATION. The deal combines all North American rights. The film is set for a theatrical release in 2014. SAGRADA is further set for theatrical distribution in Spain and France in early 2014.
The deal was negotiated by Beatrix Wesle on behalf of Atrix Films/Fontana Film and Marc Mauceri for First Run Features.


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Philly Eateries to Post Nutrition Info on Menus
Wawa said it will display the figures on in-store menus and perhaps on touchscreens.
PHILADELPHIA -- The city known for cheesesteaks will soon start dispensing nutrition labels with restaurant menus, as Philadelphia Mayor Michael Nutter will soon sign a bill ordering most chain restaurants to display calorie, fat and other nutritional information at the time of purchase, according to a report by the Associated Press.
The law takes effect Jan. 1, 2010, and follows similar legislation in New York City, California and elsewhere. The Philadelphia ordinance applies to restaurant chains -- including coffee shops, ice cream parlors and convenience stores -- with 15 or more stores. It will require eating establishments to inform their customers about calories, saturated fat, trans-fat, carbohydrates and sodium.
The Philadelphia law is the strongest of the nine passed around the country to date, according to Margo Wootan, director of nutrition policy at the Center for Science in the Public Interest. In New York, the only one already in effect, surveys show many people are changing their buying habits. "This is one of the few places in people's diets where in a split-second decision they can save hundreds, even thousands, of calories," Wootan said.
Authorities at Wawa Inc., a regional convenience store chain with about 40 locations in Philadelphia, said the company will post the nutritional information on in-store menus, and perhaps even on the touchscreens customers use to place their orders.
"The advantage of getting it on the screen is people could add up all those (sandwich) components," spokeswoman Lori Bruce said. Customers could then compare the fat or calories in sandwiches of different sizes and those with and without cheese and other extras. Customers can already do so on the company's Web site, she noted.


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Visit the GateWorld Podcast page for more about the show!
The third season of Stargate Atlantis was pivotal for the show: the writers introduced new bad guys, brought back Richard Dean Anderson's Jack O'Neill, and wrote out two major characters (… though their stories would go on). In this week's podcast GateWorld's Darren and David will talk about the highs, lows, and important character developments in Season Three — from "No Man's Land" to "First Strike," complete with showdowns, flashbacks, sisters, and fond farewells.
And we'll hear from you! In an extra-large Listener Mail segment, Stargate fans sound off about women in the franchise, keeping up with the Destiny, the studio's selling off of Stargate props, and more.
You can tune in to the GateWorld Podcast every week using iTunes or your favorite podcast catcher. Look for us at Podcast Alley PodBean.com, Mediafly, Podcast.com, or just plug in the RSS feed below wherever you listen to podcasts. You can also listen right here on the site while you browse!
Discussion – Atlantis Season Three
Leave us a voicemail on the GateWorld Podcast Hotline any time, day or night, and we'll play some of your responses in the next podcast! Just dial:
(951) 262-1647
(Long distance rates apply)
Listeners outside the U.S. can use Skype to call for just 2 cents per minute. Or, record a brief message on your computer and e-mail the MP3 or WAV file to us.
You can also leave a comment below, or post on the Podcast Feedback thread at the forum.
Next Episode: SGU's Anti-Heroes. Call in now and voice your opinion.
Highs in Season 3: some of the show's strongest episodes (Sateda, Common Ground and Phantoms), other great episodes as well (No man's Land, The Return part I, Echoes, Tao of Rodney, Sunday, Submersion and Vengeance), wonderful development regarding the friendships between the main characters, the introduction of Todd.
Lows in Season 3: Lucius, the introduction of the Asurans/Replicators (having a new enemy would've been OK, but not a rehash of SG-1's enemies), Jack O'Neill. IMO, The Return II should've been more about the SGA characters and less about a guest star from SG-1. Nice for the SG-1 fans, bad for those of us who couldn't care less about having SG-1 people on Atlantis. Another season low: the way Carson died.
Thanks for the podcast. I enjoyed listening to it!
My absolute favorite episode from this season was Common Ground, loved the way Sheppard and Todd were brought together to form an uneasy alliance. I cringe when I watch Shep being fed upon-he really looks like he's in agony there.
I HATED the way they wrote Kolya off the show, what a waste! He was a terrific villain and could have been brought back many more times as a nemesis for our team.
Season 3 was sad in that it brought an end to some beloved characters, including Carson and Elizabeth, but I did enjoy many of the eps, Phantoms and Echoes being some of the ones I liked the best.
I always wanted to see more fall-out from Shep and Co's decison to steal the jumper and return to Atlantis, but alas, that was not to be.
PS – I don't think I could ever get up the courage to call into your podcast!
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Previous Oppo phones, such as the R7, have avoided blatantly ripping off Apple's iPhone design, but the new R9, known as the F1 Plus in certain countries, leans into it. The R9 unabashedly clones the iPhone 6S, even down to some aspects of the user interface, but fails to fully capture the charm of Apple's premium phones. The result is a $188 phone that, despite the aforementioned resemblance, doesn't stand out in any meaningful way.
While the super thin bezel that gives it an almost edge-to-edge display, Oppo hasn't included a palm-rejection feature, which became apparent every time a Web page scrolled away from me due to parts of my hand inadvertently touching the edge. Also equally irritating is the way too-aggressive light sensor; I couldn't complete a round of racing game Asphalt 8 without the screen auto-dimming each time my hands accidentally covered the sensor while playing. Of course, if you want, you can turn off the auto-brightness in settings to avoid this issue. Generally, though, the phone's comfortable to hold and has a bright AMOLED screen.
How blatantly the R9 rips off the iPhone becomes glaringly evident when you open the camera app. The layout icons are the same, and the camera app also employs the same "slide your finger across the screen to change modes" feature as iOS. And like most Chinese-made phones, there's no app drawer, so all of your apps are stored on the home screen. The ever changing lock-screen wallpapers feature was neat, but it's a minor feature at best.
The rear 13-megapixel shooter does really well even when compared to flagship devices: details were clear, though colors can be a little over saturated. I liked the fast autofocus as well — it's as quick as flagship phones I've previously reviewed, such as the Xiaomi Mi 5. On the other hand, the front 16-megapixel selfie camera is pretty poor. There's no point to having a larger selfie image when the front camera lacks basic functions, such as high dynamic range (HDR). For Oppo's next phone, using a wide-angle lens for the front camera would make a lot more sense than simply increasing the size of pics, though there's a software panorama feature that acts as a "wide-angle" solution.
The phone houses 64GB of onboard storage, and includes a microSD storage expansion slot. Gaming performance was disappointing, as Asphalt 8 got pretty choppy when I turned the graphics quality to high, though the 3DMark benchmark seemed to do well. In day-to-day general performance, however, such as opening and using apps such as Facebook or Gmail, all worked smoothly. The phone's battery isn't too shabby, and lasted 11 hours while looping a video in airplane mode.
OPPO R9 Unlocked Phone Price in China
Wholesale Price:$188.00
Unfortunately, given the disappointing performance and copycat design, the Oppo R9 (aka F1 Plus) doesn't feel like a worthy buy, but if you're still keen, you can get it now through Oppo's online store.


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- Description
Quick Overview
Wella Professionals introduces their "free of" care system that instantly repairs damaged hair to give smooth, nourished and moisturized hair. The Wella Professionals Elements Light Renewing Conditioner strengthens the hair from within and makes it shiny and strong. The scientifically developed NuTREE complex enriched with natural tree extract protects hair against keratin degeneration. The lightweight paraben free Elements conditioner helps repair hair fiber and preserves hair's natural vitality.
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How to use product
Apply Wella Elements conditioner to towel-dried hair.
Massage gently into the hair.
Rinse well and towel-dry.
Expiry Date : Click Here August 2018
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By Trisha Kukreja
True to its name, it's a very light weight conditioner and goes perfectly well with the Wella Elements Shampoo from the same range!
Posted on 6/20/2017
By kavita
if you need a conditioner that will not make your hair limp and greasy but transform i to shiny soft tresses...then this is the one product you need.
the consistency of this product is neither thick nor too runny...it gives adequate moisture to your hair and is amazing for summers since it wont weigh your hair down
Posted on 5/28/2017
By Ben Sushmita
This is just an awesome product. I wish i had this long back, this elements shampoo and conditioner made my frizzy hair into smooth and soft hair.
Posted on 3/13/2017
By js majhi
got a pocket size by nykaa and loving it use it every 2 day .and seen a change in my hair ...brings softness and makes frizz free just loving it
Posted on 2/3/2017
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Real Estate News
One Thousand Museum Now Beginning Vertical Construction
by Sep Niakan | June 22, 2015
The One Thousand Museum designed by Zaha Hadid is finally going to begin the vertical construction phase. Developers of the project have filed their plans for two cranes to be placed on the site of the One Thousand Museum for 19 months. One of...
Real Estate News
One Thousand Museum Site Purchased, Construction Will Begin Soon
by Sep Niakan | September 10, 2014
Developers of the One Thousand Museum purchased its site in downtown Miami, and has asked Regalia Group to partner up. 1000 Biscayne Tower LLC, owned by Louis Birdman and Gregg Covin, purchased the double-property site for $36 million in cash....
Real Estate News
One Thousand Museum Lawsuit Resolved, Property Purchase Can Now Finalize
by Sep Niakan | July 21, 2014
The lawsuit between developer Marc Roberts and the owner of a BP gas station where the One Thousand Museum will be, has finally been settled. Back in 2007, Roberts sent a letter warning the BP station owner that his contract to purchase the...
Real Estate News
Hadid's One Thousand Museum to Command $900 per Square Foot?
by Sep Niakan | June 24, 2013
As new images and design details are revealed about Zaha Hadid's proposed condominium project in Downtown Miami, One Thousand Museum, it has been uncovered that the starting price points for condos and penthouses within the tower will be $4...
Real Estate News
Miami's Skyline to Change with Zaha Hadid's Newest Condo Design: One Thousand Museum (PHOTOS)
by Sep Niakan | April 12, 2013
Pritzker Prize-winning architect Zaha Hadid Fresh from the mind of Pritzker Prize-winning architect Zaha Hadid comes One Thousand Museum, only recently revealed and primed to change the shape of the downtown Miami skyline. The condo...


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Reviews written by registered user
|147 reviews in total
C'mon guys, you weren't even trying. When you have non-actors you have
to spend some time coaxing decent performances out of them, not just go
with what are obvious first or second takes. And don't have your lead
actor slowly raise his knife to the heavens, time and time again, like
someone out of an old silent movie, or have a fight scene with monsters
that looks like an asinine game of patty cake. And don't have your
female cast members who are killed by these trogs appear to have
nothing more than a few facial scratches. If you want to go through all
the travail of making a movie then make it count when you do -- don't
be sloppy and lazy. It's not enough to gather a bunch of friends and
family members and wannabes together and shoot something on the fly. If
you're not serious about it then all you've got is a home movie.
Therefore, this is across-the-board awful, even as a low-budget lark. A real actor in the lead role would have helped immensely, but unfortunately Matt Farley is the star and he's appallingly inept. The only worthwhile performances are from Sharon Scalzo and Steff Deschenes, although they both suffer from having to mouth some terrible dialogue, and get saddled with embarrassingly directed death scenes.
A funny takeoff of 'Misery' with the star of the movie himself (Caan)flat on his back again. Sandra Bernhard plays a less-crazed, but more abrasive sort-of substitute for the Kathy Bates character. This episode also features a bittersweet side to Vanessa Marcil's Sam and the actress handles it well. It's just a TV show, but realistically there is no way a man in a coma for 20 years would wake up and both mentally and physically be essentially back to normal. But playing it closer to reality would have veered the show off into ER-like dramatics that it's not prepared to handle. But that aside, on a pleasant visual note there is also a trio of pretty olive-skinned beauties on display in this episode -- the standout, in my mind, the strikingly pretty Morena Baccarin (formerly featured prominently in the short-lived 'Firefly' Sci-Fi series).
First try and find this film... a VIDEOTAPE TV movie from 1975. That's
right: it wasn't even shot on film. But if you do find it (good luck),
view this sorry thing with below-the-floor expectations and maybe, just
maaaaaaybe you'll squeeze some entertainment out of it. Honestly,
there's no need to bother trying. This is godawful nonsense that only
rates a viewing for completists of the scintillating screen careers of
Andrew Stevens. Michael Parks, and Tige Andrews. Andrews is listed as
"Special Guest Star" which seems odd, until you realize by the end of
the film that ol' Tige is barely on screen after the first few minutes.
Dick Clark produced this sad spectacle and probably doesn't even recall
it now (or would be willing to admit to it).
Let's see, what have we got: an embarrassing $1.99 werewolf mask... an embarrassing $1.99 wool-knit beanie hat worn by Michael Parks... a $2.99 replica of the Woodstock Festival stage, and a quick shot of some garbage strewn about in a clearing beyond the stage that is so small that this must have been where the Hamster Woodstock was held, not the full-size festival... a dune buggy chase with a werewolf at the wheel ... and flower child Beckie (Belinda Belaski) who is so tuned into the frequency of her dead pooch named Virgo that she can "feel his pain is not over." But your own pain can end with a quick skip to the finish, or a tossing of this garbage in the nearest receptacle.
Actually I make this sound better, in a supremely cheesy sense, than it truly is. Mostly it's tedious. Be warned. Woof!
This is an obscure time filler from Columbia Pictures. Obviously lots
of musical numbers, and they're not bad. But it's too bad that Phil
Harris is the star. Not that he's awful or unlikeable, it's simply that
he's too light and uninteresting a performer to carry a picture. Harris
was leading his own band at the time and he's fine in that function,
and in being a second banana to the antics of Jack Benny on radio, but
his starring in a film is equivalent to seeing Carson bandleaders Tommy
Newsome or Doc Severinson trying to be leading men.
The stale amnesia angle doesn't help either, but there it is. Harris and his assistant Eddie "Rochester" Anderson are painters doing a job at a nightclub. Harris tries to help in his small way with struggling singer Leslie Brooks, and clumsily falls on his head in the process and takes the ol' amnesia route. By circumstance and guesswork he's made to believe he's actually a bandleader. Oddly enough, he's got an innate talent for it and becomes a success -- and Anderson, even though he knows Harris is really a painter, attaches himself as a Man Friday in order to ride along on Harris' bandleader success. Brooks plays an angle as well, but falls in love with him in the process. There's a few more contrivances, a few more musical numbers, and a predictable finish. There's also a quick joke where Harris as his screen character makes fun of the real Harris as a bandleader. Actually, the only reason to watch this film is to catch the always pleasing Eddie Anderson. Obviously his race kept him from being the star of this movie, and that's too bad because he's the only one of Jack Benny's cast members who could carry a film -- and he certainly could have carried this one. Instead it's Harris who fills the screen (almost literally considering his bulk). Nonetheless, it's a pleasant little movie that's easy on the brain... but hard to see considering its virtual unavailability.
Any movie that is defended with the idea that it can only be enjoyed by
viewing after taking drugs... well, c'mon, you know it's got to be
pretty bad. And this is bad, no mistake about it. Sure, it's very
colorful, and for the drug-inclined it's an eye-popping visual
"overdose" of nostalgic psychedelia...
But at the the heart of this foolish fruity farrago is an offensive story of a geeky middle-aged man obsessing pervertedly over a pretty young woman living next door -- that obsession fueled by non-stop Peeping Tom activity. This sick invasion of privacy is treated as an excitable, joyous, comical diversion. It leads the geek professor to wild flights of fancy and lunatic dreams, giving us plenty of bizarre sequences filmed in full 60's psychedelic-meets-Richard Lester glory. But, wacky comedy-wise, it's weak tea in comparison to Lester's 'The Knack' or 'Help!' And considering the obvious Lester-Beatles influence (including the actor playing Birkin's boyfriend having a distinct Liverpudlian accent) it's no surprise that George Harrison provides the score.
Too bad that the score is awful. Whole scenes go by with virtually no dialogue, thus a catchy pop score from Harrison would be welcome, and add to the nostalgic value of the film beyond the psychedelia. Unfortunately we get the Shankar-sauce sitar-period Harrison. Only those finding a nostalgic trip from Indian music that sounds like the wailing of out-of-tune violins (or worse, the sound of a cat trapped inside bagpipes) will be pleased. Otherwise, it's an ear-offending slog.
And otherwise, filmically, you get a frantic but professional performance from Jack Macgowran, a lot of eye-catching shots of pretty cult-figure Jane Birkin, and a few comic bits that work.
I guess Fonda's character can be considered "Crazy Larry" for his
driving antics, but I'm not sure why Mary is considered "dirty." As for
the film, it's not really dirty or crazy, more dated and lazy. Vic
Morrow does the umpteenth version of the grousing sheriff in pursuit of
the robbers, snapping at underlings with a pained hemorrhoidal delivery
that is severely one note. When an assistant can't get him info about
Mary fast enough, even using a computer, he complains about the
computer! He's so ill-humored throughout that watching him becomes a
chore. On the other side, there's the fetching Susan George, who is
very easy on the eyes. Too bad her accent goes in every direction. Her
character is also distinctly unlikeable for most of the movie. Fonda
and Roarke are dull. In fact, Fonda is so utterly passive an actor that
casting him in this role can only be attributed to 'Easy Rider' yet
it's Dennis Hopper who would have fit the bill here. Fonda strains
under the film's need to have him project an out-there personality.
Imagine Fonda in Roarke's role and Hopper as Crazy Larry. More
interesting, hypothetically, in my opinion.
The direction is routine. For a car chase film this one isn't very exciting, with many shots held far too long. There's also a cameo from Roddy McDowall that provides the usual bug-eyed, jaw-drop take he's so fond of. And considering how un-clever this film is, the ending seems appropriate -- the filmmakers having run out of ideas and shrugging "this is all we could think of." As I recall when the film came out that it was a hit. Now it seems dated, especially the dialogue (and some of the dialogue is just plain weird, almost non sequitur-like). Oh, and Tarantino loves this movie. But Tarantino loves virtually every movie from the early-to-mid-70's so that's not saying much.
This is titled Diamante Lobo, although it was filmed in Israel and produced by the Israeli team of Golan Globus -- and its title means 'Wolf Diamond' in Spanish -- but it goes by many other names, including 'God's Gun.' Go figure. It's a Matzo Ball Western, hold the spaghetti. But it might as well be covered in pasta since it's got the look and the sound (especially the music score) of a tried-and-true Italian oater. Not to mention the old hand himself, Lee Van Cleef, is the star. Or should I say double-the-star since he plays two roles. Even so, he's overshadowed by Jack Palance playing only one role, but with enough grinning-breathy bravura (also known as ham acting) to fill three roles of his own. Poor drunk Richard Boone adds a few moments but his snarling menace is undercut by his late-career dissipation and his voice being dubbed by someone else. Leif Garrett is mostly mute, which helps, and doesn't sing, which helps even more. Danning is cute, and the rest of the cast and the film itself, is wallpaper. The word I'm searching for is "blah."
Sadly, this is an awful grab bag of mostly trivial stories. Certainly
it is ambitious and interesting as a concept, and Paris looks
beautiful, but the producers didn't rein in the directors and what
appears winning in theory becomes a lazy mishmash in execution. Each
director was given five minutes of screen time and two days to shoot
their film. Almost all of the directors figured they could dispense
with writers and do it themselves. A bit of ego, a bit of film school,
and a misunderstanding that even five minutes of screen time requires a
writer's hand, especially so since the short time frame demands concise
story telling skills.
Indeed, some of these film makers, e.g. Christopher Doyle, have barely sat in a director's chair, much less be worth trumpeting as members of an extraordinary group of visionaries. And the concept involves love stories and the love for Paris. What connection is there with this concept and the filmography of Joel and Ethan Coen? In fact the heavy American and British presence seems more mercenary than visionary from the producing end of things. Ben Gazzara and Gena Rowlands playing two Americans finalizing their divorce in a restaurant could have been filmed in New York or Chicago and shipped over to France for attachment to the movie. Worse, this episode relegates a giant of French cinema, Gerard Depardieu, to the minuscule part of the restaurant owner. There's nothing wrong with having some stories about tourists and expatriates, but this collection relies far too much on it. The bulk of the Parisians in this film are relegated to background chatter and bit parts. Surprisingly, even the city is relegated to background fodder. It appears that almost none of the film makers have any sense of Paris, or what to do with it given the opportunity to make a small film there. Many take place in nondescript indoor locations, or in the case of the Elijah Wood episode, a meaningless dark street straight out of 'Sin City.' Story wise, this is a director's film. Therefore the writing is weak and in some cases almost non-existent. In the case of Cuaron's episode with Nick Nolte, even the direction is non-existent (almost entirely a long shot track of Nolte yakking away to his nubile daughter as they walk down a street -- once again, a heavy American element with no trace of Paris except some dialogue). Some of the vignettes have "punchlines", while others merely fade away or end pointless and lost. The two most "commercial" feature Steve Buscemi in a cartoonish skit in a Metro station, and an absurd tryst between Elijah Wood and a vampiress. Both stand out but for the wrong reasons. Buscemi is forced to say nothing throughout his episode, and to behave like a punching bag for no reason. At least it IS snappily directed, and makes its point and ends with an exclamation. But it's also more clichéd American-in-Paris tourism. The Wood vampiress story not only doesn't belong in this film, it is also extremely predictable as a vampire sketch.
Many of the other stories seem either a small part of a bigger film, or a made-up hodgepodge to fill five minutes. To each his own as to the merits of the results. Certainly this smörgåsbord provides enough promise in its theme to delight those who think they're getting a taste of Paris along with humanistic stories (rather than the usual gangster, spy, or sleaze films using the city for its location). But I think the producers should have demanded that the directors adhere to the concept rather than allow them free rein to indulge in half-thought out skits that have only an arbitrary connection to the locations of the title city.
A young William Boyd stars as the captain of the title ship who is
involved in a serious maritime challenge on behalf of the U.S. against
arch rival Britain. It's a race to see which country's best sailing
ship can get from Foochow, China to Boston the fastest. To do this they
must sail across the Pacific and around the southern tip of South
America. The prize is not only the Foochow tea trade but the winner
gets the other's ship.
Boyd's journey quickly becomes encumbered by a young stowaway (Junior Coughlin) and the unexpected additions of a young woman and her craven fiancé. When one of Boyd's crew offers to help the woman and her fiancé escape, Boyd's troubles really start brewing up. From there it's fights, attempted mutiny, budding romance, and comedy relief... and, oh yes, a race to be won. The film has its moments and, thankfully, has none of the eye-rolling acting hysterics prevalent in so many silent movies. But it also doesn't have much personality. Boyd's star part lacks color, and the female lead's part isn't any better. Obviously the filmmakers keyed on the young boy to sell the movie to the real target audience.
The VHS copy I viewed comes with an intro from Junior Coughlin that looks like it was taped in the 80's.
Lots and lots of hair. The only enjoyment in watching this film is the
nostalgic kind. That early 70's TV look, that cast, and those hairdos.
Shatner is startling to look upon at first, with his oily hair and
lamb-chop sideburns (not to mention his outfits). Then there is Richard
Castellano, who is never less than repugnant to view, with a
terrorist-torn-out-of-bed hairstyle that is a work of grunge art. His
character is not much better.
As for the content of this TV movie, there's little to say. It was a pilot for a proposed 1973 NBC series called 'The Prosecutors.' It never got past this film. Familiar cast, familiar story, plodding execution. With almost iconic types like David Doyle and Murray Hamilton popping up, along with the camp master himself Shatner, it's hard to pay much attention to the story: you spend more time thinking "I remember that actor!" Unfortunately, the star of the film is the colorless James Olson. Now, if Shatner had been put in place of Olson this might have been far more entertaining. Oh, and Susan Stafford has a small role. Very pretty, but showed far more brains and talent when she got OUT of showbiz later.
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Monster Trucks Slot
|Progressive: No
|Jackpot: 500 Coins
|Reels: 5
|Paylines: 15
|Coin Values: 0.001 up to 0.02
|Bonus Game: Yes
|Wild Symbol: No
|Multiplier: No
|Scatter Symbol: No
|Free Spins: Yes
|Released: 2013
|Software: Slotland Entertainment (WinADay)
Monster Trucks Slot
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General Overview
Vrrrroooommmm! The monster trucks are coming your way in a brand new slot game. No reason to be afraid, though – monster trucks are so-called because they are vehicles similar to pick up trucks, purpose built to stand out from the crowd for the monstrous size of their wheels and suspension. So you're in for a monstrously good time with this penny slot, which has a monster truck competition theme.
Monster Trucks
Monster Trucks is a 5 reel, 15 pay line video slot. Coin bet size is a tiny $0.001 up to $0.02. The maximum coin bet size is 75, for a potential jackpot of 500 coins. Developed using proprietary software, this instant play game is available only at the Win-a-Day online casino. It's a great slot for low rollers who want the fun of playing the slots without making a major cash commitment. The slot icons star the monster trucks themselves, naturally. Even the high card symbols reflect the powerful theme.
Win-a-Day slot games seem to concentrate on offering one special feature per game. In this case that feature is free spins. The scatter symbol is adorned with a racing flag motif; three or more of these appearing on the reels will award you five free spins. During the free spins session, every new scatter that you see will trigger an additional free spin, up to a total of 20 free spins in a row. What this means is that you can get a lot of slots action for a small initial wager.
The low bet size of this penny slot is a big advantage for modest gamblers, although high rollers probably will not be interested. While the game is definitely not feature packed, the retriggerable free spins do add a note of excitement – and more chances to win. The obvious limitation is that the game is available only at Win-a-Day.
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Looks like 4 Bed Dream Home in Little Elm is no longer available on Rent.com which means this information is likely out of date.
SPACIOUS 4 Bed Dream Home... With Numerous Upgrades...
4 Bed 2 Bath 2,120 square feet - Fireplace, 2 car garage, central air-conditioning, refrigerator, oven, dishwasher, disposal, microwave, washer/dryer, ceiling fans, vaulted ceilings, recessed lighting, tile backsplash, corian countertops, jetted tub, intercom system, sprinkler and security systems, AND stainless steel appliances... This Is A Never-Been-Lived-In Lennar Home In The Beautiful Community of Sunset Pointe... Great Neighborhood... Excellent School District... Close to Shopping Areas... Parks, Playgrounds... and Best of all Next to Lake Lewsville... Your Ideal Living Situation! It Wont Last Long...
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Woven striped mini skirt with crisscross ties at waist, featuring tassel ends. Fringe hem and contrast waistband. Side pockets. Lined.
Honey Bop Mini styled by the FP Me community
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Wholesale Women's Dresses
When it comes to the whole business of dresses, there's no wholesale clothing distributor who knows their stuff like J5 Fashion. Offering cheap clothes online for many years, our designer, boutique and bespoke dresses are carefully curated, attentively tested and enthusiastically prepared to reach your shop floor without headaches and without fuss. Our ladies dresses styles are second to none, with our collection ranging from cocktail dresses, prom dresses and celebrity style. Don't hesitate, jump in!


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In Brief
New Taiwan representative to HK runs into visa delay
The arrival of a new Taiwan representative to Hong Kong may be delayed, as a visa for the new managing director of the Chung Hwa Travel Service - Taiwan's de facto consulate in the city - has not yet been approved by the Hong Kong government, Taiwan's Mainland Affairs Council said. The Taipei-based Central News Agency quoted the council saying that Pao Cheng-kang, the current managing director of the travel service, would return to the island in a few days, as his term had expired. But his successor, Yang Chia-chun, director of the council's department of legal affairs, has yet to be granted a working visa by Hong Kong.
UK bird flu halts applications
Processing of applications for importing poultry and poultry products from Britain have been suspended following confirmation of a case of bird flu there. A spokesman for the Centre for Food Safety said the decision was taken after confirmation of H5N1 bird flu on a poultry farm.
Euro V diesel on sale soon
Euro V diesel will be available in the market as early as December 1, when a new concessional duty on the cleaner fuel becomes effective. The legislature yesterday endorsed a government resolution to introduce a 55 cents cut in this vehicle diesel duty from HK$1.11. The fuel contains 80 per cent less sulfur than ultra-low-sulfur diesel.
Property rates waiver approved
A motion calling for the waiving of all next year's property rates, subject to a ceiling of HK$5,000 per quarter, was passed by lawmakers. It also called for a cut in the rates charge from 5 per cent to below 5 per cent. The motion was passed by a 20-0 vote by directly elected lawmakers and 18-1 by functional constituency members, with some abstentions.
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The Cointelegraph
A new report announced an imminent tipping point for Fintech. The report by one of the world's largest consulting firms is based on a survey of 16,000 customers in 32 countries and interviews with 140 industry experts.
Recently, the Capgemini's World Payments Report 2014 projected mobile payments to grow 60.8% by 2015.
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A vintage-themed wedding whisks the wedding party and guests to magical bygone days. The ceremony and reception are infused with classic charm that gives subtle elegance to the event. You don't need a lot of money to have a great vintage wedding. In fact, this theme lets you bargain hunt without guilt, since each blast-from-the-past item is all part of the plan.
To have a vintage wedding on a budget, scour consignment stores and thrift shops. With persistence, you should be able to find some excellent decorations for your ceremony and reception. That being said, while it might be tempting to go for small objects, sometimes bigger is better. A large vase, for example, can fill a space more cheaply than a dozen small ones. Some craft stores have event sections where you can rent certain high price items. You can, for example, rent an arch, candelabras and even lampposts. Vintage cake toppers can be especially fun to find, and many online consignment stores offer toppers at a reasonable price. If you're not set on holding onto your wedding dress after the ceremony, even that can be rented!
As far as the particular décor, imitation pearls add elegance at an affordable price. This classic symbol will definitely and an old-time feel to the reception. You can use lace white trimmings for soft femininity, and rustic signs that look vintage provide a personal touch. Birdcages with a shabby chic look can be either placed on a table or hung.
To complete your theme, choose vintage wedding invitations. At weddingpaperdivas.com, you can also purchase vintage save the date cards, place cards, and rehearsal dinner cards.
It's easy to create a beautiful vintage wedding on a budget. This theme is perfect for anyone who appreciates the romance of earlier eras. When you find exactly what you're looking for, you can pull of this classic wedding type with ease and enjoy your special day.
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"I had originally planned on going with a custom design from a stationer. However, I loved the design on the Draped Elgance invitation and decided to utilize Wedding Paper Divas instead. This invitation (response card and thank yous in addition) far exceeded my expectations. I ordered in the gold font and the thermography printing style gives it a beautiful sheen in natural light. Additionally, I was more than happy with the quality of the standard paper option."


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Current cancer management faces several challenges, including the occurrence of residual tumor after resection, the use of radioactive materials or high concentrations of blue dyes for sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. To overcome these limitations, we developed a real-time intraoperative imaging device that, when combined with near infrared (NIR) fluorescent molecular probes, can aid identification of tumor margins, guide surgical resections, map SLNs, and transfer acquired data wirelessly for remote analysis.
We developed a new compact, wireless, wearable, and battery-operated device that allows hands-free operation by surgeons. A CCD-based consumer-grade night vision viewer was used to develop the detector portion of the device and the light source portion was developed from a compact headlamp. This piece was retrofitted to provide both NIR excitation and white light illumination simultaneously. Wireless communication was enabled by integrating a battery-operated miniature radio-frequency video transmitter into the system. We applied the device in several types of oncologic surgical procedures in murine models, including SLN mapping, fluorescence-guided tumor resection, and surgery under remote expert guidance.
Unlike conventional imaging instruments, the device directly displays fluorescence information on its eyepiece. When employed in SLN mapping, the locations of SLNs were clearly visualized, even with tracer level dosing of a NIR fluorescent dye, indocyanine green. When utilized in tumor resection, tumor margins and small nodules not visible to the naked eye were readily visualized. In a simulated point-of-care setting, tumors were successfully located and removed under remote guidance using the wireless feature of the device. Importantly, the total cost of this prototype system ($1200) is significantly lower than existing imaging instruments.
Our results demonstrate the feasibility of using the new device to aid surgical resection of tumors, map SLNs, and facilitate telemedicine.
Without image guidance, surgeons are required to remove large surgical margins around what they perceive as tumor due to the similarity of diseased to surrounding healthy tissues. In some parts of the body such as the brain, surgeons do not have the luxury of removing sizeable healthy tissue for fear of inducing irreparable damage to complex brain physiology. Despite progress made to enhance contrast between tumor and normal tissues, the human eye is not capable of detecting the contrast signals with high sensitivity in the operating room (OR). This limitation further exasperates adequate tumor resection, resulting in the presence of cancerous cells at or near the boundaries of surgically removed tissues1, 2. However, recent advances in medical imaging technologies have facilitated the use of imaging instruments to guide surgery in the OR. Besides unsatisfactory sensitivity and accuracy, modern intraoperative imaging modalities suffer from high cost, complex instrumentation and time-consuming image analysis, further limiting accessibility of bona fide standard of cancer care available to patients. For sentinel lymph node (SLN) biopsy, the standard breast cancer staging procedure can also cause adverse effects on patients and healthcare workers3–7. For instance, radioactive tracers emit hazardous ionizing radiation to patients as well as surgeons4, 8 and the large doses of blue dyes used for visualizing SLNs with the naked eye may cause adverse reactions 3, 5–7. Moreover, some surgical procedures often require a team of experienced oncologic surgeons, radiologists and pathologists to work together, who are oftentimes not available in most rural clinics and developing countries. To address these challenges, there is a compelling need for accurate, affordable, user-friendly, portable, and versatile intraoperative imaging system. Not only should they offer real-time imaging capability in a confined surgical suite, they should also be able to bring remote collaborative efforts from geographically separated medical professionals to the bedside.
The high detection sensitivity and use of non-ionizing radiation have facilitated the development of several optical systems to detect and assess tumor margins9–18. However, most of these systems require graphic display of results on a monitor, which can distract surgeons from focusing on critical surgical resection of tumors.
To overcome the above limitations, we have designed a goggle-based device that does not require remote monitoring. The system is affordable, battery-operated, compact, wireless, wearable, and allows hands-free surgical operation (Fig.1A). The overall design of system is illustrated in Fig. 1B. With this device, functional information provided by near infrared (NIR) fluorescence of molecular probes can be directly displayed with adjustable amplification on its goggle eyepiece. Both NIR light-emitting diode (LED) and NIR-depleted visible LEDs served as integrated light sources on the device, providing concurrent fluorescence excitation of NIR molecular probes and illumination of the surgical field. Consequently, the device is designed to allow one eye to capture the functional information from the NIR fluorescence while the other eye can view both tumor and surrounding tissue anatomy with unaided eyepiece. The system is further equipped with the capability to transfer wirelessly real-time video to a remote site, where the current view for the goggle wearer can be graphically displayed. An expert at the remote site can see what is happening during the surgery from the point of view of the local surgeon and provide expert advice and comprehensive image analysis if needed. Hence, the new system can be potentially applied to point-of-care medical interventions, real-time pathological assessment of tissues, and remote medical consulting.
The detector portion of the device consists of an off-the-shelf night vision viewer (iGEN NV20/20-IC, First Texas Products, El paso, TX, USA) that utilizes a Sony ICX254AL diagonal 6mm CCD image sensor. Default objective lens of iGEN NV20/20-IC was employed. An emission filter was mounted on the objective lens. The 830nm band pass filter (#302470, CVI Melles Griot, Albuquerque, NM, USA) was selected for SLN mapping application, whereas the 820nm long pass filter (#8480, Omega Optical, Brattleboro, VT, USA) was used for tumor imaging. The light source portion of the system is a modified headlamp (Trailfinder Series 6 LED Headlight, Energizer, St. Louis, MO, USA). This headlamp was converted to a light source by disconnecting two central white LEDs and replacing them with two 770nm NIR LEDs (#LED770-03AU, total radiated power of 18mW at 50mA, Roithner Lasertechnik, Vienna, Austria). Two additional peripheral white LEDs were left intact to provide white light illumination. The NIR light is collimated by existing optics, which provides a field of view approximately 0.3m in diameter at 1 m. All LEDs are driven by an onboard circuit powered by three AAA batteries. No excitation filter was used for SLN mapping but a 775nm short pass filter (#NT64–615, Edmund Optics, Barrington, NJ, USA) was mounted onto to the headlamp for tumor imaging. The detector and light source were mechanically integrated onto a customized helmet allowing hands free operation of the device For real-time video transfer during operation, the device was connected to a RCA composite cable, and then to a USB video capture cable (#SVID2USB2NS, Startech, Lockbourne, OH, USA) that was plugged into a laptop computer (T500, Lenovo, Morrisville, NC, USA ). For wireless video transfer, a pocketsize RF transmitter/receiver set (#SCI-PVTS2, Spy Chest, Crestview, FL, USA) replaced the RCA composite cable for completely connection-free use. For all studies, the device was set to operate at a video rate of 12 frames per second (fps) and a working distance of 0.5m. Fluorescence images were acquired with the device's NIR sources, while white light images were acquired under room light illumination. All images and videos were acquired and stored using frame grabbing software (GrabBee). For detection sensitivity measurements, three parallel samples (n=3) of indocyanine green (Sigma-Adrich, St. Louis, MO, USA) in DMSO at various concentrations (0nM, 1nM, 3nM, 5nM, 7nM and 9nM) were prepared in a 96-well assay plate (#3603, Corning Incorporated, Corning, NY, USA) and imaged. Mean intensity values for individual wells were measured by ROI analysis in ImageJ and subsequently evaluated by linear regression against the known concentrations.
Indocyanine green was purchased from Sigma-Adrich (St. Louis, MO, USA). MMPSense FAST 750 was purchased from VisEn (Waltham, MA, USA). LS301 was synthesized by literature method19, except that CEM microwave peptide synthesizer and Gilson HPLC system were used to prepare the peptide and purify the final product. The molecular probe consists of cysteine-glycine-arginine-aspartic acid-serine-proline-cystein-lysine peptide sequence and a near infrared fluorescent dye, cypate. This dye has absorption and emission maxima around 780nm and 830 nm, respectively, in biological media. The dye-peptide conjugate (LS301) was characterized by spectroscopic methods, analytical HPLC, and electrospray ionization mass spectrometry.
All animal procedures were conducted in compliance with Washington University Animal Studies Committee's requirements for the care and use of animals in research. Six-week-old male C57B mice and male NCR nude mice were purchased from Taconic Farms (Hudson, NY, USA). For animal studies, the mice were anesthetized with ketamine and xylazine cocktail (80 mg/kg and 13 mg/kg, respectively, intraperitoneal injection). The hair overlaying the region of interest was removed by gentle clipping and cream depilatory (Sally Hansen, Morris Plains, NJ, USA). The mice were killed immediately after imaging experiments by IP injection of 150 mg/kg sodium pentobarbital (Somnosal, MedVet, Worthington, OH, USA).
For SLN mapping, 6-week old male C57 black mice (Taconic Farms, Hudson, NY, USA) (n=5) were anesthetized and 3.75nmoles of indocyanine green in PBS solution were administered intradermally into both front paws (n=5×2). The subcutaneous axillary region was exposed by incising and retracting the overlaying skin. NIR and white light on the imaging device were simultaneously turned on, providing both fluorescence excitation and surgical field illumination. SLNs were identified and resected under image guidance. After resection, surgical sites were inspected thoroughly with the device under different signal amplification settings. For comparison, ischiatic lymph nodes were also excised and imaged as non-fluorescent controls. SLNs and control lymph nodes were examined with the system ex vivo. Excised tissues were embedded in Tissue-Tek OCT medium (Sakura Finetek, Torrance, CA, USA) and stored at −80 °C.
For tumor imaging, 200,000 4T1luc cells were injected subcutaneously in both sides of the chest (n=5×2) of 6-week old male nude mice. Approximately 2 weeks after cell injection, mice were anesthetized with ketamine and xylazine as described above. LS 301 solution (100 µL of 100µM in 20% DMSO/80% saline) was injected intravenously via lateral tail vein. At 24 hours post-injection, non-invasive bioluminescence images and digital radiographs of the mice were acquired with the In-Vivo Multispectral FX PRO (Carestream Health, Inc. Rochester, NY). For bioluminescence imaging, luciferin (150 mg/kg) was injected intraperitoneally 5 minutes prior to imaging. Luciferin is a substrate for the enzyme luciferase needed to generate bioluminescence, which was detected by 5-minute exposure with 8×8 binning. Digital radiographs were acquired by 90-second exposure using the radiographic phosphor screen. Fluorescence-guided surgeries were subsequently carried out using the new goggle device. A midline incision was made from sternum to throat and skin reflected laterally to expose the mammary tissues. Tumor tissues were identified and resected under image guidance. In three cases, partial resections around the tumor margins were performed to demonstrate the capability of identifying residual tumor tissues. Surgical sites were then re-examined, to find residual cancerous tissues and small tumor nodules. Resected tumor and muscle tissues were examined ex vivo to compare fluorescence in tumor to non-tumor tissue. Tissues were subsequently embedded with Tissue-Tek OCT (Sakura Finetek, Torrance, CA, USA)and frozen for histology.
Nude mice with 4T1luc tumor implanted subcutaneously in the right flank were anesthetized. MMPSense 750 FAST solution (100 µL of 20 µM in PBS) was injected intravenously via lateral tail vein. At 24 hours post-injection, fluorescence-guided tumor resection was performed in a simulated point-of-care setting using the new imaging system. Overlying skin was incised and reflected to expose the subcutaneous tissues. Fluorescence of the cancerous tissues was detected with the device. Real-time florescence videos were transferred wirelessly to a remote computer during surgery using the RF transmitter/receiver set described above. Surgical instructions by a remote scientist were relayed back to the lab via a mobile phone.
Resected lymph nodes, tumors, and control tissues were frozen in OCT. The tissues were sectioned in the cryostat to 8 microns thickness. For fluorescence microscopy, slides were taken directly from the −80 °C freezer to the Olympus BX51 upright epifluorescence microscope (Olympus America, Center Valley, PA, USA). Images were acquired for NIR (775+/−50 nm excitation, 810 nm longpass dichroic, and 845+/−55 nm emission filters) and Green (480+/−40 nm excitation, 505 nm longpass, and 535 emission filters) fluorescence as well as brightfield. NIR fluorescence, green autofluorescence and brightfield images were merged together to create composite images in ImageJ. The same slides were then stained with hematoxylin and eosin (H&E). Matching regions with fluorescence microscopy were found and imaged.
Our prototype device is currently designed to work with NIR fluorescent probes with excitation and emission wavelengths centered at 780 nm and 830nm, respectively. Representative examples of NIR fluorescent dyes include indocyanine green, an FDA-approved NIR dye20, 21, and cypate, a readily functionalized indocyanine green analog 22. We demonstrate that the device can detect fluorescence from as low as 1 nM of indocyanine green dye (Fig. 1C).
We applied the prototype device in two types of oncologic surgical procedures to demonstrate the potential of the system in fluorescence-guided surgery. First, device was applied in SLN mapping in a murine model. We administered 3.75nmoles of indocyanine green solution intrademally into both forepaws of five mice (n=10). Indocyanine green subsequently migrated into surrounding lymphatic vessels and accumulated in the lymph nodes on both sides within 5 minutes post injection. SLNs were clearly tracked (Fig. 2A–C, Movie 1 [online]) and subsequently excised under real-time guidance of our device (Fig. 2D). After excision, surgical sites were thoroughly re-examined with the device under multiple signal amplification ranges. The SLNs were further confirmed by histological findings (Fig. 2E).
Having demonstrated the feasibility of imaging SLNs, we further explored the potential of using the new device for guiding tumor resection and detecting non-obvious small tumor nodules. For this study, we used a NIR fluorescent molecular probe, LS 301. LS 301 is an imaging agent developed in our lab that preferentially binds to tumor margins (Fig. 3A). It is composed of a peptide sequence that binds integrin receptors on proliferating tumors and a near infrared fluorescent dye that is used for optical imaging, with a fluorescence peak centered at 830 nm. These features make LS 301 attractive for use in assessing surgical margins intraoperatively, which is suitable for our goggle study.
4T1-luc orthotopic mammary tumor model was used for this study. Although ectopic tumor models are widely used in cancer research, orthotopic tumor models generally present a more realistic natural state of the cancer, as tumors may behave differently in different tissues. Five mice that bore 4T1-luc mammary tumors in both breasts were studied (n=10). Briefly, 10 nmol of LS 301 solution was injected intravenously via lateral tail vein. At 24 hours post-injection, fluorescence-guided surgical removal of the tumors were carried out with the aid of the imaging device. Bioluminescence imaging was conducted to confirm the presence and position of cancer prior to surgery (Fig. 3B). High fluorescence signal at the tumor regions were observed when imaging non-invasively (Fig. 4A). The fluorescence contrast between tumors and normal tissues was high, despite attenuation by scattering and absorption of light in the skin and overlying tissue. Tumors were subsequently resected under guidance of imaging device. The system was able to clearly delineate tumor margins (Fig. 4B, Movie 2 [online]). With direct visualization of tumor margins, surgical margins could be improved by minimizing the amount of surrounding healthy tissues removed. Residual tumors and small nodules that are not obvious to the naked eye were detected with the goggle system (Fig. 4B). LS 301 rapidly distributes throughout the body immediately after intravenous injection. Preferential uptake in the tumor and rapid clearance from non-target tissues within 1 hour post injection leads to high contrast in the target tissue. After surgery, organs were examined ex vivo at 24 hours (Fig. 4C). Biodistribution studies show that LS 301 is excreted through hepatobiliary and renal pathways. Consequently, in addition to the high tumor uptake that persists up to 24 hours post injection of the imaging agent, significant amounts of the probe is retained in the liver and kidneys, which correlates with the probe's excretion pathway. Histological assessments confirmed the malignant nature of the excised tissues and microscopy further revealed high fluorescence level in the tumor margins (Fig. 4D).
A unique advantage for telemedicine provided by this system is the ability to relay the actual point-of-view of the goggle wearer to a remote expert. In contrast, a static system would not capture the change in gaze direction as the local surgeon rotates his or her head up/down or left/ right. To test initial feasibility of this concept, we evaluated the new system with wireless data transfer in a telemedicine simulation. We limited the scope of this study to traditional radio-frequency (RF) communication, where the prototype device was coupled to a pocketsize RF transmitter/receiver set. Our device is also capable of coupling with other wireless communication methods such as 3-G networks. Using the RF transmitter, we conducted a fluorescence-guided tumor resection procedure in a simulated remote point-of-care setting. In this experiment, we used a commercial fluorescent molecular probe (MMPSense 750 FAST) to explore the capacity of our device to detect fluorescence signals from diverse optical imaging probes that operate through different contrast reporting strategies. Unlike LS 301 that preferentially binds to protein receptors on margins, the fluorescence from MMPSense 750 FAST is only detected in tumors with high expression of active matrix metalloproteinases (MMPs). High levels of MMP expression is a biomarker of highly proliferating tumors. MMP-mediated contrast mechanism offers lower background and higher signal to noise ratio compared to conventional fluorescent probes. By accessing the MMP activity in tumors, progression of cancer and therapeutic effects of anti-cancer treatments may be monitored24. In this situation, an experienced oncologist could guide the assessment of tumors from remote sites. . In this study, the functional status of the tumor was imaged by a veterinarian performing the surgery through the eyepiece and simultaneously transferred wirelessly to the computer of a remote imaging scientist (Fig. 5). The video was displayed in real time, enabling remote assistance. Based on the data transmitted, the scientist interacted verbally in real-time with the veterinary surgeon in the lab through a mobile phone to guide the surgery. Tumors were successfully located and removed under the wireless collaboration and the functional information of tumor status (MMPs activity) was stored at a remote computer. While this simulation simplifies clinical conditions, it illustrates the potential this imaging device holds for telemedicine and point-of-care applications.
Incomplete tumor resection is a major factor that compromise long-term survival rate of cancer patients. Fluorescence-guided surgery is an emerging technology that holds great potential to provide a viable solution to this problem. In this study, we developed and demonstrated the use of a new device that can detect non-obvious small tumor lesions, guide SLN biopsy and allow remote telemedical guidance.
To date, most fluorescence-guided intraoperative imaging modalities are limited to 2-D planar imaging due to the technical difficulties in implementing tomography in real time. In reality, 2-D imaging systems do not provide sufficient depth-information to guide surgery that is 3-D in essence. Although a 2-D functional-anatomical composite image could be projected on a monitor10, 25, surgeons still use naked eyes to survey the actual tissue anatomical landscape in real time. To overcome this obstacle, our system is designed as a goggle device that does not require remote display on a computer monitor. During operation, surgeons can simultaneously view the functional status in the eyepiece with one eye and obtain the anatomical information to navigate the region of interest with the unaided eye.
Without cost-effectiveness, any image-guided technology could not be readily translated into clinics on a global scale, regardless of its efficacy. Hence, an important component of our design process was to reduce the instrument cost and size, with the long-term goal of extending its use to underserved populations and rural areas. For instance, instead of building a detector from high-end scientific grade cameras that are generally large and expensive such as FLARE10 and Hamamatsu Photodynamic Eye26, the detector portion of the device was developed from a CCD-based consumer-grade night vision viewer. We have demonstrated the detector is able to provide high detection sensitivity in vivo along with low cost and compact size.
The detector operates on four AA batteries and offers 10 levels of adjustable gain settings. Each gain setting corresponds to a dynamic range of signal amplification that automatically optimizes and displays the detected NIR light level. This dynamic amplification feature is crucial for surgical applications, as it automatically optimizes and normalizes the fluorescence intensity displayed in real time. This circumvents the need to tediously re-adjust settings manually with specialized image-processing software in the dynamically changing surgical environment. In addition, the simple gain-setting control on the device allows the surgeon to manage the device directly, without the assistance of other personnel. These features could significantly simplify the procedures and lower the labor cost in the OR.
We demonstrated that the prototype device provides high detection sensitivity and signal-to-background contrast, which can help surgeons to locate non-obvious small cancerous lesions and SLNs. When utilized in tumor resection, the device detected tumor margins, small nodules, and some residual tumors that are not detectable with the unaided eye. This approach may improve surgical margins by reduce the size of healthy tissues resected, minimize the probability of incomplete resection, and decrease the need for follow-up surgery. When employed in SLN mapping, the device can clearly indicate the positions of SLNs even with tracer level dosing of indocyanine green, which circumvents the potential side effects caused by radioactive tracers and blue dyes.
In this study, wireless communication is enabled by integrating a battery-operated miniature RF video transmitter into the system to test initial feasibility of this concept. Coupling our device to standard communication platforms such as 3-G will facilitate real-time visual/auditory collaborative relations, as demonstrated in this study. Thus, direct communication can be made between clinicians at leading medical institutions and their counterparts in rural or remote areas, even across continents. The total cost of the prototype system is approximately $1,200, up to 100 times less than previously reported intraoperative fluorescence imaging systems such as FLARE™ (approximately $120,000)10, Hamamatsu Photodynamic Eye (approximately $40,000)26 and GE FIGS system (approximately $15,000)25.
There are limitations to the study. Murine models were used to demonstrate the feasibility of image-guided SLN biopsy and tumor resection with our device. However, large animal models are needed to simulate human studies, which is the subject of a second-generation device. Additionally, the monocular visualization system may affect depth perception and require surgeons to use their dominant eyes for the goggle piece. This may present some logistical problems for the surgeon. Finally, our first prototype is not the optimal ergonomic design for any surgeon. In this prototype, we aim to demonstrate the concept rather than translating it into clinics in its current form. The next generation device will be smaller, lighter, with more functionalities and better ergonomics.
In summary, we have demonstrated the development and feasibility of using a hands-free and wireless device for NIR fluorescence-guided surgery. The device facilitated tumor resection and SLNs biopsy procedures. Furthermore, the device is affordable, portable, user-friendly, and provides the surgeon with wireless communication in a telemedicine setting, facilitating its potential use in rural clinics and point-of-care settings, where inexperienced clinicians may perform complex surgical procedures under real-time remote guidance of expert surgeons and physicians.
This study was supported in part by the US National Institutes of Health grants R01 EB008111 and EB 008458. Mr. Liu was supported in part by the US Department of Defense Breast Cancer Research Program Predoctoral Traineeship Award (W81XWH-11-1-0059). Dr. Akers was supported by Award Number K01RR026095 from the National Center for Research Resources. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health and the Department of Defense.
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Competing Interests Statement
The authors declare that they have no competing financial interests.
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Classical Music is the first genre of music ever created. It started in the Mid 1600s.
Musical RootsEdit
Classical music being the first genre of music in history it therefor does not have any routes. Classical Music started in Austria & Germany. It later became popular in Italy & France and spread throughout Europe.
Stylistic MovementsEdit
Classical Music had a very distinct style for its time. This included bad teeth, funny looking wigs and aristocratic clothes. Musically the music is supposed to embrace emotions of love and it embraces gracefulness. It can also express ideas of life and death. This is common in an Opera. Classical music uses many different instruments some of which include organs, pianos, basses, violins, bassoons and flutes.
Early PioneersEdit
Styles Influenced By Classical MusicEdit
The first American style of music that Classical Music gave birth to was Jazz. Ragtime also became popular in the late 1800s and early 1900s. From Jazz Blues & Rhythm and Blues came about. From those two genres Rock and Roll came about. Classical Music has influenced every genre of music that has ever seen the light of day.
Modern Classical Music MusiciansEdit
- Roger Waters
- Lang Lang
- Luchiano Pavorotti
- Andrea Bocelli
- Sting
- Maestro Lorin Maazel & The New York Philharmonic
- Dvorjak
- George Girshwin


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Question: American automobile companies are becoming more motivated to improve the
American automobile companies are becoming more motivated to improve the fuel efficiency of the automobiles they produce. It is well known that fuel efficiency is impacted by many characteristics of the car. Describe what these boxplots tell you about the relation-ship between the number of cylinders a car's engine has and the car's fuel economy (mpg).
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Answer to relevant QuestionsThe boxplots display bottle prices (in dollars) of dry Riesling wines produced by vineyards along three of the Finger Lakes in upstate New York. a) Which lake region produced the most expensive wine? b) Which lake region ...Look again at the histograms of test scores for the three Statistics classes in Exercise 57. a) Overall, which class do you think performed better on the test? Why? b) How would you describe the shape of each ...The discounts negotiated by the car buyers in Exercise 32 are classified by whether the buyer was Male 1code = 02 or Female 1code = 12. Compare the discounts of men vs. women using an appropriate display and write a brief ...FAOSTAT, the Food and Agriculture Organization of the United Nations, collects in-formation on the production and consumption of more than 200 food and agricultural products for 200 countries around the world. Here are two ...The histogram shows the December charges (in $) for 5000 customers from one marketing segment from a credit card company. (Negative values indicate customers who received more credits than charges during the month.) a) Write ...
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Dave Britton, PGA
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Dataw Island Club
100 Dataw Club Rd
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100 Dataw Club Rd
Saint Helena Isl SC 29920-3836
(843) 838-8250
100 Dataw Club Rd
Beaufort, SC 29902
Beaufort, SC 29902
(843) 838-8250
Dave Britton is a PGA Professional in Saint Helena Island, SC. The PGA of America comprises 27,000 men and women professionals with one singular goal in mind - to make the game of golf more enjoyable for you.
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Student Work
The New York Times published Adela Suliman's M.S. '16 master's project about American Sufism.Read her work.
Medicine Underground was produced by the Armies and Spies 2016 Workshop. Foreignpolicy featured the story by Ellen Francis.See the website.
Adj. Prof. Walt Bogdanich, and M.S. '15 Jacqueline Williams & Ana Graciela Méndez investigated the Panama Canal.Read the A1 New York Times article.
Marybel Gonzalez '16 M.S. writes her Master's Project on the Quinceanera in transition.Read how her project got published in The New York Times.
Amy Lieberman '14 M.A., Politics Concentration, wrote her thesis on Arizona's immigration patrol rebellion.Read the published article in Slate.
Sara Jerving '14 M.A., Business Concentration, wrote her thesis on how Liberians thought Ebola was a government scam.Read her article published in The Nation.
Ben Taub '15 M.A., Politics Concentration, wrote his thesis on teens who join ISIS, which became the lead story in The New Yorker.Learn how the story came together.
Caroline Spivack '16 M.S. reported on women who are first responders in humanitarian actions.Read the Global Citizen Press article.
Shandukani Omphulusa Mulaudzi '16 M.S. reported on a woman arraigned in a Kenyan court for getting an abortion.Read the Global Citizen Press article.
Annika Hammerschlag '16 M.S. reported on women who compete in the Olympics and face discrimination at home.Read the Global Citizen Press article.
Sarah Ravani '16 M.S. reported on a campaign to raise awareness of abuses against the Baha'i community in New York.Read the NY City Lens article.
Five students collaborated with journalists around the world, mining information and stories on shipping-related topics.Read about their work.