text:
December 28, 2013 BY Aaron Hope
It had been basically gone for over two years, so the Nike Air Max Command is choosing to ease its way back into the NSW rotation this coming January. The colorways coming up soon are probably the simplest to date, which might be interpreted as superlative elegance if you like these styles. The one pictured above is as simple as it gets in black with a white midsole and Dark Grey branding. Click through to get a closer look at the textured panels that take these up a notch, then pre-order your pair so they'll ship next month from Titolo.
Nike Air Max Command Leather
Color: Black/Black-Dark Grey
Style Code: 409998-017
Source: Titolo
Filed under: Nike Air Max
Tags: Nike Air Max Command


text: IBM MAINFRAME: Question on conditional SUMing using SORT Portal | Manuals | References | Downloads | Info | Programs | JCLs | Master the Mainframes Question on conditional SUMing using SORT IBMMAINFRAMES.com Support Forums -> DFSORT/ICETOOL IBM ManualsQuick References View previous topic :: :: View next topic Author Message cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Mon Sep 05, 2011 2:06 pm Post subject: Question on conditional SUMing using SORT Hi, I have a file as shown below - Code: 1 D 1 _ 1 _ 2 D 2 D 2 _ 3 _ 4 D 4 _ I need to eliminate the duplicates on the first field (i.e. 1,2,3,4...) and have the the following columns added - a. Count of first field b. Count of first field with a 'D' in the second column For the above data, the output should be - Code: 1 3 1 2 3 2 3 1 0 4 2 1 We are looking at sum on elimination of duplicates + conditional count (D) here. For the summation part, I can use an INREC with 1's padded and SUM on the padded fields with SORT FIELDS on first field. How do I add the second column which would increment for all D's found within a unique first field. Regards... Back to top EscapaSenior MemberJoined: 16 Feb 2007Posts: 1399Location: IL, USA Posted: Mon Sep 05, 2011 2:52 pm Post subject: Hi, You can use something like this.. Code: //STEP0100 EXEC PGM=SORT //SYSOUT DD SYSOUT=* //SORTIN DD * 1 D 1 _ 1 _ 2 D 2 D 2 _ 3 _ 4 D 4 _ //SORTOUT DD SYSOUT=* //SYSIN DD * INREC IFTHEN=(WHEN=INIT,OVERLAY=(11:C'00000001',19:C'00000000')), IFTHEN=(WHEN=(3,1,CH,EQ,C'D'),OVERLAY=(19:C'00000001')) SORT FIELDS=(1,1,CH,A) SUM FIELDS=(11,8,ZD,19,8,ZD) /* Output will be Code: 1 D 0000000300000001 2 D 0000000300000002 3 _ 0000000100000000 4 D 0000000200000001 You can also try for solution with use of OUTFIL sections Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Mon Sep 05, 2011 4:14 pm Post subject: Escapa!!! It worked!!! Thanks a loooooot!!! Back to top THINKSRINIIIWarnings : 1New UserJoined: 09 Jan 2009Posts: 88Location: India Posted: Mon Sep 05, 2011 5:12 pm Post subject: OUTFIL and SECTIONS: Code: //SYSIN DD * SORT FIELDS=(1,1,CH,A) INREC IFTHEN=(WHEN=(3,1,CH,EQ,C'D'),OVERLAY=(10:C'1')) OUTFIL NODETAIL,SECTIONS(1,1, TRAILER3=(1:1,1,COUNT=(EDIT=(STT),SIGNS=(+,-)), TOTAL=(10,1,SFF,EDIT=(STT),SIGNS=(+,-)))) Output Code: 1+03+01 2+03+02 3+01+00 4+02+01 Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Wed Sep 07, 2011 6:08 pm Post subject: Is it not possible to add multiple conditions in the SORT. Say, I have a condition like given below - Code: IFTHEN=(WHEN=(1,1,CH,EQ,C'A'), OVERLAY=(3:C'00001')), IFTHEN=(WHEN=(1,1,CH,EQ,C'A',AND,2,1,CH,EQ,C'D '), OVERLAY=(4:C'00001')), For a sample output like shown below - Code: A_ A_ AD A_ The output should be A41 A - the value 3 - The # of times it occurs 1 - The # of times it occurs with a 'D' Regards... Back to top Bill WoodgerDFSORT ModeratorJoined: 09 Mar 2011Posts: 7315 Posted: Wed Sep 07, 2011 6:22 pm Post subject: Reply to: Question on conditional SUMing using SORT Is it not possible? Is that not to avoid the Yes or No answer? It seems only a small variation on your original query, and therefore of the code provided for you. Have you tried it? Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Wed Sep 07, 2011 6:41 pm Post subject: Hi Bill, I tried it out and it seems like, if SORT finds the first condition matches for a particular row, it would not take into consideration that row for the next evaluation. The above could be due to the fact that the conditions are not exactly mutually exclusive. Thoughts??? I'm tried with - Code: IFTHEN=(WHEN=(1,1,CH,EQ,C'A'AND,2,1,CH,NE,C'D '), OVERLAY=(3:C'00001')), IFTHEN=(WHEN=(1,1,CH,EQ,C'A',AND,2,1,CH,EQ,C'D '), OVERLAY=(4:C'00001')), A and not 'D' A and 'D' This above criteria - eventhough, mutually exclusive - didn't work. The count for the first instance was set to 0 itself, whereas the second field came up just fine. Back to top Bill WoodgerDFSORT ModeratorJoined: 09 Mar 2011Posts: 7315 Posted: Wed Sep 07, 2011 6:56 pm Post subject: cybertaurean wrote: [...] I tried it out and it seems like, if SORT finds the first condition matches for a particular row, it would not take into consideration that row for the next evaluation. [...] When there is something that "should" reasonably work, and it doesn't, that is the time to hit the manual to find out what you are doing wrong. If you take your above thought to the manual and read-up on the IFTHEN, you should be able to get to what you want. "Why doesn't that work?" is usually better as "What I am not doing properly?" and sometimes "What idiotic rubbish did I invent to think that that would work?". The manual usually resolves which of the real questions it is. Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Wed Sep 07, 2011 7:04 pm Post subject: Thanks, Bill for your time. Let me try rummaging thru the manual then Back to top kratos86Active UserJoined: 17 Mar 2008Posts: 148Location: Anna NGR Posted: Wed Sep 07, 2011 7:16 pm Post subject: By default the processing of IFTHEN stops when a condition is satisfied. In order to continue the validation you need to code HIT=NEXT parameter. Check your manual/search the forum on more details about this parameter. Back to top Bill WoodgerDFSORT ModeratorJoined: 09 Mar 2011Posts: 7315 Posted: Wed Sep 07, 2011 9:37 pm Post subject: Reply to: Question on conditional SUMing using SORT Mmmm.... Kratos gave you a bigger "hint". So you were right in how you were thinking, and are now aware how to code for it. Hopefully you found it in the manual yourself first, and got that extra "glow" from confirming it for yourself. It's a useful process, let's call it a tool. Think, manual, think again, manual - then colleagues, techies, ibmmainframes. Use the web at any point you like as well. That'll get the majority of your problems solved, and quicker each time as you get more experience with it. Applies to all software/systems. Back to top SkolusuSenior MemberJoined: 07 Dec 2007Posts: 2205Location: San Jose Posted: Wed Sep 07, 2011 9:46 pm Post subject: cybertaurean, As Kratos86 pointed out you need Hit=NEXT to evaluate the next ifthen when the first condition is true. Read here for IFTHEN with HIT=NEXT A better coding would be Code: //STEP0200 EXEC PGM=SORT //SYSOUT DD SYSOUT=* //SORTIN DD * A_ A_ AD A_ //SORTOUT DD SYSOUT=* //SYSIN DD * SORT FIELDS=COPY INCLUDE COND=(1,1,CH,EQ,C'A') INREC IFTHEN=(WHEN=INIT,OVERLAY=(4:C'00001',X,5C'0')), IFTHEN=(WHEN=(2,1,CH,EQ,C'D'),OVERLAY=(10:C'00001')) //* which would produce this Code: A_ 00001 00000 A_ 00001 00000 AD 00001 00001 A_ 00001 00000 Now you can sum the fields at pos 4 and pos 10 for a length of 5 bytes which would give you the desired results. In order to the summing you need to sort which is a moot point as you only A records. So it is better to use the reporting features and get the counts. Code: //STEP0400 EXEC PGM=SORT //SYSOUT DD SYSOUT=* //SORTIN DD * A_ A_ AD A_ //SORTOUT DD SYSOUT=* //SYSIN DD * SORT FIELDS=COPY INCLUDE COND=(1,1,CH,EQ,C'A') INREC IFTHEN=(WHEN=(2,1,CH,EQ,C'D'),OVERLAY=(3:C'1')) OUTFIL REMOVECC,NODETAIL, TRAILER1=(1,1,2X,COUNT=(M11,LENGTH=5),2X,TOT=(3,1,ZD,M11,LENGTH=5)) //* will produce Code: A 00004 00001 Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Mon Sep 12, 2011 3:57 pm Post subject: @Bill: Yeah... I had come across that, and got that "glow" feel after it worked . Thanks!!! Special Thanks to Kratos86 for the insight!!! @Kolusu: Thanks, as always BTW... Had to be tweaked per the requirement (HIT NEXT at the right places)... The entire thingy listed below (with all the "confidential" (if any) stuff removed, ofcourse) - Code: SORT FIELDS=(1,34,CH,A) SUM FIELDS=(37,5,ZD,42,5,ZD, 47,5,ZD,52,5,ZD, 57,5,ZD,62,5,ZD, 67,5,ZD,72,5,ZD, 77,5,ZD,82,5,ZD, 87,5,ZD,92,5,ZD, 97,5,ZD,102,5,ZD, 107,5,ZD,112,5,ZD, 117,5,ZD,122,5,ZD, 127,5,ZD,132,5,ZD, 137,5,ZD,142,5,ZD) INREC IFTHEN=(WHEN=INIT,OVERLAY=(37:C'00000',42:C'00000', 47:C'00000',52:C'00000', 57:C'00000',62:C'00000', 67:C'00000',72:C'00000', 77:C'00000',82:C'00000', 87:C'00000',92:C'00000', 97:C'00000',102:C'00000', 107:C'00000',112:C'00000', 117:C'00000',122:C'00000', 127:C'00000',132:C'00000', 137:C'00000',142:C'00000')), IFTHEN=(WHEN=(33,2,CH,EQ,C'AB',AND,35,2,CH,EQ,C'D '), OVERLAY=(42:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'AB'), OVERLAY=(37:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'CD',AND,35,2,CH,EQ,C'D '), OVERLAY=(52:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'CD'), OVERLAY=(47:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'EF',AND,35,2,CH,EQ,C'D '), OVERLAY=(62:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'EF'), OVERLAY=(57:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'GH',AND,35,2,CH,EQ,C'D '), OVERLAY=(72:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'GH'), OVERLAY=(67:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'IJ',AND,35,2,CH,EQ,C'D '), OVERLAY=(82:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'IJ'), OVERLAY=(77:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'KL',AND,35,2,CH,EQ,C'D '), OVERLAY=(92:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'KL'), OVERLAY=(87:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'MN',AND,35,2,CH,EQ,C'D '), OVERLAY=(102:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'MN'), OVERLAY=(97:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'OP',AND,35,2,CH,EQ,C'D '), OVERLAY=(112:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'OP'), OVERLAY=(107:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'QR',AND,35,2,CH,EQ,C'D '), OVERLAY=(122:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'QR'), OVERLAY=(117:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'ST',AND,35,2,CH,EQ,C'D '), OVERLAY=(132:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'ST'), OVERLAY=(127:C'00001')), IFTHEN=(WHEN=(33,2,CH,EQ,C'UV',AND,35,2,CH,EQ,C'D '), OVERLAY=(142:C'00001'),HIT=NEXT), IFTHEN=(WHEN=(33,2,CH,EQ,C'UV'), OVERLAY=(137:C'00001')) OUTREC FIELDS=(1,4,C',',5,10,C',',15,10,C',',25,8,C',', 37,5,C',',42,5,C',',47,5,C',',52,5,C',', 57,5,C',',62,5,C',',67,5,C',',72,5,C',', 77,5,C',',82,5,C',',87,5,C',',92,5,C',', 97,5,C',',102,5,C',',107,5,C',',112,5,C',', 117,5,C',',122,5,C',',127,5,C',',132,5,C',', 137,5,C',',142,5) Thanks!!! Back to top SkolusuSenior MemberJoined: 07 Dec 2007Posts: 2205Location: San Jose Posted: Mon Sep 12, 2011 11:25 pm Post subject: Reply to: Question on conditional SUMing using SORT cybertaurean, I see that you are validating 4 contiguous bytes, so why not search the entire 4 bytes as a single filed? If you have any data in pos 35 for 2 bytes you can force it to have spaces when the field doesn't contain 'D ' and you can avoid coding the HIT=NEXT on every IFTHEN statement. The initial When=INIT will force 2 spaces in pos 35 if the value does not contain 'D ' , with a CHANGE parm. By doing so you are validating the complete 4 bytes as a single field and it becomes unique. Also you don't have to specify the positions and complete length to initialize the values to zero. You have 22 fields to be initialized to zero each with a length of 5 bytes (22 X 5 = 110 ). So 110C'0' will put 110 zeros from pos 37. since your intention is to put '1' on the last byte you don't have to specify the entire 5 bytes on the overlay as we already initialized the values to zero, you can simply code the pos of the last byte to have '1' . You have to overlay '1' for every 5 bytes starting from pos 41. ie ( 41, 46, 51, 56,....146). Also since we know the summing fields all have the same format we can specify it just once using FORMAT=ZD like shown below. ex: Code: //SYSIN DD * INREC IFTHEN=(WHEN=INIT, BUILD=(1,34,35,2,CHANGE=(2,C'D ',C'D '),NOMATCH=(C' '),110C'0')), IFTHEN=(WHEN=(33,4,CH,EQ,C'AB '),OVERLAY=(041:C'1')), IFTHEN=(WHEN=(33,4,CH,EQ,C'ABD '),OVERLAY=(046:C'1')) .....all your IFthen conditions SORT FIELDS=(1,34,CH,A) SUM FIELDS=(037,5,042,5, 047,5,052,5, 057,5,062,5, 067,5,072,5, 077,5,082,5, 087,5,092,5, 097,5,102,5, 107,5,112,5, 117,5,122,5, 127,5,132,5, 137,5,142,5),FORMAT=ZD OUTREC FIELDS=.... //* Back to top cybertaureanNew UserJoined: 22 Dec 2008Posts: 85Location: US Posted: Tue Sep 13, 2011 8:46 pm Post subject: You are right, Kolusu!!! The approach mentioned by you is definitely much more optimized. Thanks!!! Back to top View previous topic :: :: View next topic IBMMAINFRAMES.com Support Forums -> DFSORT/ICETOOL All times are GMT + 6 Hours Page 1 of 1 Search our Forum: Similar Topics Topic Author Forum Replies Posted SORT to unpack a feild shr_amar DFSORT/ICETOOL 7 Fri Jul 07, 2017 4:32 am How to write Specific Fields from Mul... Padhu SYNCSORT 6 Thu Jul 06, 2017 10:26 am Optimize sort inrec parse vishwakotin DFSORT/ICETOOL 6 Mon Jun 26, 2017 11:15 pm Reduce CPU Times for Join Sort santoshn SYNCSORT 12 Sat Jun 10, 2017 1:40 pm Db2 load job abending in SORT mistah kurtz DB2 4 Mon Jun 05, 2017 3:58 pm © 2003-2017 IBM MAINFRAME Software Support Division Mainframe Wiki | Forum Rules | Bookmarks | Subscriptions | FAQ | Tutorials | Contact Us

subset: commoncrawl


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Boneless Pork Roast
READY IN: 1hr
Recipe by tgobbi
Found on a recipe card at the supermarket. It looks very simple and delicious.
Top Review by Theresa P
This was very good.Made it this afternoon for dinner.Great flavorful pork!!!Nice and simple,sometimes thats the best!!
See Discussion:34 Reviews 1 Tweak
Ingredients Nutrition
- 2 lbs boneless pork roast
- 1⁄4 teaspoon dried sage
- 1⁄4 teaspoon dried rosemary
- 1 garlic clove, crushed (or chopped)
- salt & pepper
Directions See How It's Made
- Preheat oven to 325 degrees Fahrenheit.
- The meat should be at room temperature for best results.
- Place pork in roasting pan.
- Sprinkle the top of the roast with sage, rosemary, garlic, and salt and pepper.
- Bake for 50 minutes (25 minutes per lb).


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A part of the Ann Arbor Brewing legacy and its resident brewing company, Arbor is one of the more famous brewpubs among the many that dot Bangalore's streets, catering to the influx of the young crowds working and living here. The place is styled alongside American influences, with the décor, lighting and seating reminiscent of the local pubs in Ann Arbor. True to its source, Arbor's speciality is craft beer, although it functions as a full-fledged brew pub serving other alcohol as well as food. While dishes such as the Greek Passion Pizza, the Arbor-ger and Flaming Chicken are sumptuous and also easy on the pocket, the real USP is the variety of beers, each one crafted to a specific taste. The crowd favourites are the Bangalore Bliss, Brassiere Blonde, Raging Elephant or the Phat Abbot. Unlike typical bars, Arbor's speciality as a brew pub is that every glass of beer is freshly prepared from distilleries within the place itself. ABC even has bartenders-cum-beer 'technicians' who will explain the nuances between different types of handcrafted beers and let you choose the one most suited to your tastes, creating a fulfilling experience for chugging enthusiasts. The spacious area inside ABC and the background music mean that the ambience is highly peaceful and conducive to catching up and having conversations, something that loud tunes or large crowds generally deter. It is best to catch a reservation before visiting ABC as the place is packed to the hilt on the weekends.
- 1800


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"Rude and dismissive consultant Gynaecologist"
About: Torbay Hospital / Gynaecology Torbay Hospital Gynaecology TQ2 7AA
Posted by Aurora Devon (as ),
In December 2010 I had my third appointment with the Directorate of Obstetrics and Gynaecology at Torbay Hospital regarding an Endometrial cyst on my ovary.
I never saw the consultant I was supposed to see. I saw a different person each time and had to start from the beginning again with my story and symptoms.
On this third occasion in December 2010 I saw a man who dismissed my concerns about surgery saying abruptly "Well if you're not having surgery why are you here?". When I asked him about crippling fatigue he said in a frustrated and aggressive tone "I don't know any 38 year old who isn't exhausted!"
I have since been diagnosed with Chronic Fatigue Syndrome and Fibromyalgia plus a possible heart condition. Due to this treatment and the fact that I seem to see a different specialist every time, I have resisted any follow-up regarding my Endometriosis symptoms.
Response from Deborah Lannon, Communications Officer, Torbay and South Devon NHS Foundation Trust 4 years ago
Dear Ms Devon,
We are very sorry to hear about your experience in December 2010. We would like the opportunity to discuss your experience with you so that we may try our best to resolve it and so that we learn from your feedback.
If you are happy to talk to us about this, please contact our Patient Advice & Liaison Service (PALS) so they can look into your situation in more detail.
A PALS Officer is available in person, Monday to Friday, between 10.00am and 2.00pm. You can contact them by calling 01803 655838 or on our 24 hour freephone number 0800 02 82 037. They can also be contacted by Text Phone on 01803 654742, by FAX on 01803 617162, or by email (your email will go direct to our PALS Service).
We look forward to hearing from you so that we can address the issues you have raised.
South Devon Healthcare NHS Foundation Trust
- {{helpful}} of {{total()}} people think this response is helpful
- Was this response helpful? Yes | No
Thank you for your feedback.
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text:
Little Charley Bear - Big Little Charley
Little Charley Bear, Episode 04 - Big Little Charley
Series Synopsis
Follows the adorable Charley, who under the watchful eye of the Narrator James Cordon, uses his imagination and role play to go on adventures to discover new things about himself and the world around him.
Episode Synopsis
Episode 04 - Big Little Charley
Charley wants to be taller and bigger than he is. But when he actually becomes a giant he finds he's so big there are a lot of fun things he just can't do any more. Maybe his normal size is fine after all.
Previous Episode Synopsis
Episode 49 - Charley's Birthday Surprise
Charley thinks all of his friends have forgotten his birthday, but really they are arranging a party for him as a surprise.
Future Episodes
- 11:50am Tuesday, January 29 (R)
- 11:50am Wednesday, January 30 (R)
- 11:50am Thursday, January 31 (R)
- 11:50am Friday, February 01 (R)
- 11:50am Saturday, February 02 (R)
- 11:50am Sunday, February 03 (R)
- 11:50am Monday, February 04 (R)
- 11:50am Tuesday, February 05 (R)


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The hotel offers 172 rooms with spectacular views of the Valle de M�xico, including executive floors and suites, plus 14 boardrooms, a concierge service, and a business centre with 5 spacious meeting rooms. Guests of this city hotel are welcomed in the lobby with 24-hour reception and check-out services, a hotel safe, currency exchange, and lift access to the upper floors. A kids' club, bar, restaurant, caf�, car park and garage also feature. Internet access, and room and laundry services are also available for additional fees.
The establishment is located in the newest financial and corporate sector of the capital city, close to Expo Bancomer Santa Fe and a few steps from Latin America's largest shopping complex. It is also surrounded by a square full of restaurants, which offer an extraordinarily diverse selection of tastes created by internationally recognised chefs.
The rooms feature two telephones, a TV, Internet access, tea and coffee making facilities, an ironing set, hairdryer, air conditioning and central heating. All are en suite with a bath and shower. Double or king-size beds are available. Further in-room amenities include a hifi, safe and minibar.
Guests are invited to take a refreshing dip in the indoor swimming pool, unwind on the sun terrace or work out in the gym. Massages and spa treatments are also available for additional fees.
The hotel accepts American Express, Diners Club, MasterCard and VISA as payment methods.
Room Facilities:
Direct dial telephone
Satellite cable TV
Internet access
Tea Coffee
Iron and board
Double bed
King size bed
Individual airconditioned
Individual heating
Disabled bathroom


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Shortcake Biscuits
Be the first to review
READY IN: 35mins
Recipe by swirlycinnacakes
Yummy. Top with fruit, cream, or whatever your heart desires.
See Discussion:
Ingredients Nutrition
- 2 cups flour
- 6 tablespoons sugar, divided
- 1 tablespoon baking powder
- 3⁄4 teaspoon salt
- 1⁄4 cup unsalted butter, cut into 1-teaspoon-sized pieces and frozen
- 2 cups whipping cream, plus
- 2 tablespoons whipping cream
- 1 egg yolk
- 1 teaspoon vanilla extract, divided
Directions See How It's Made
- Preheat oven to 375 degrees F. In a food processor, place the flour, 2 tablespoons sugar, baking powder, and salt. Blend briefly. Add the butter and pulse until the butter is the size of peas.
- Pour mixture into a bowl, add 1 cup of the cream, and combine with a fork until moistened. Immediately turn out onto a lightly floured board and knead about 10 times. Small lumps of butter should be visible.
- Roll out to a 3/4-inch thickness. Keep dough in a square shape. Cut into 6 pieces and place on an ungreased cookie sheet. (You can do this either with a knife, for square biscuits, or with biscuit cutters for round ones. If you don't have biscuit butters, you can also use one end of a clean 8-oz tomato sauce can.).
- Mix the egg yolk with 2 tablespoons of cream and 1/2 teaspoon vanilla, and brush on the tops of the biscuits. Sprinkle with 2 tablespoons sugar. Bake 15 to 20 minutes or until golden brown.


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So I'm 5 ft & he's 5'5...I always had a thing for tall guys. I once dated a guy who was 6'2 & I loved it. But this guy I'm talking too is 5'5 & skinnier than me.
So girls...I'm 5ft with a full body. We all get insecure & I feel like I would get insecure.. I'm fit though. I'm thick but toned. How would you feel? I feel like I could crush him :(
Guys: do you like that? Like, I have an ass but I'm also a full boned person. I'm not a twig . How would you feel if you were skinny & your girl was big.. is that sexy for you? I'm not fat fat! But I'm not skiny. I'm middle & I work out. I do track etc
Most Helpful Guy
I think from how you sound, he must be very happy.00|00|0


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Title- Story's End. (Storybound #2)
Author- Marissa Burt.
Publish date- 2013.
Publisher- Harper.
*May contain spoilers for book 1 in the series!*
Review time...
(A Brief) Synopsis:
The tide is still changing in Story, and darkness is getting closer as Una tries to figure out the truth she learnt- and hide it from those who have become her family- and everyone tries to save Story.
What I thought:
I can't remember what year it was that I read Storybound- I do believe it was sometime before it's initial publication date, since I read an ARC- but ever since then I have just been waiting to get my hands on the sequel. This made, when that finally came around this year, for a few things I could probably have foreseen-
1. I remembered practically nothing!
By the time I was 150 pages (or there abouts) through, I had a pretty good idea of what was going on, but most of the time before that I was very stumped; I'm not always fond of the way events from a previous book are gone over, as a refresher, but here I wished there was more! It took me far too long to work out that WI's were Written In's, and I've no idea where Indy came into the story, or why Snow was so angry at her mother.
2. I think I had grown too old for it.
For me this wasn't a story I thought could be read by any age and enjoyed in unique, important and memorable ways, and that meant I felt like I was seven or eight years too old for the majority of it. I did not know if it was my memory or that it truly did regress a little, because the characters frustrated me and acted in whinging and whiney ways, and terrible things are happening! I got so frustrated that they were still falling over jealousies and such when war was being waged and they were trying to save Story!
There were some truly wonderful scenes, though, that I felt even if I didn't feel a lot else: I loved the Westerns, Una's discovery at the end, the coming together of the animals.
Rating: Poor.
A bit of a disappointment, to be honest, since I truly loved the first book- I'm glad this is the end, though. It was fitting, the way it all finished.


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Spring 2017 Undergraduate Peer Mentors
Howdy! My name is Alexis but you can call me Alex, and I am the loudest and proudest member of the class of 2017! A-WHOOP! I am from Houston, Texas and my major is Interdisciplinary Studies 4-8 English Language Arts/ Social Studies. I hope to teach 8th-grade social studies back in Houston after I graduate. In my free time, I enjoy playing soccer, dancing, and watching Netflix. This is my second semester as a UPM and I am looking forward to working with Ms. Ribeiro and her INST 362 class!
My name is Ashley, and this is my fourth semester participating in the UPM program! I am a junior in the College of Education, with a concentration in 4-8 language arts and social studies. Other interesting facts about me are that I am a family person, enjoy reading, camping, and hanging out with my family and friends. In the pictures, my sister and fiance are featured because they are my constant support and very best friends. Otherwise, I am just a student and appreciate the opportunity to work and grow alongside talented co-workers.
This semester, I am a UPM for Ms. Carter in two of her Reading 461 sections. It is an honor and a pleasure to work with Ms. Carter and her students. I look forward to a great semester!
My name is Audrey Vincenzo and I am a junior Interdisciplinary Studies (EC-6) major from Northlake, Texas (north of Fort Worth). I love to spend time with friends and family, and one of my favorite things to do is to create art.
I hope to teach in an elementary school one day, especially second grade. One of my major goals as a teacher is to inspire my students to love learning, but I care about kids on a personal level as well. I want to help them reach their full potential and be a positive influence in their lives.
This is my fourth semester working as an Undergraduate Peer Mentor, and I am very excited to be working with Dr. Burghardt and her students in INST 362!
My name is Blair Ikeler and I am a Junior EC (PK-6) major! I am from Mansfield, Texas, which is where I hope to return upon graduation and teach. I also hope to pursue my Master's degree in Education at some point post-graduation. I have had a passion for teaching as long as I can remember, and I cannot wait to make an impact on all the sweet babies that walk through my classroom door someday. In my spare time, I enjoy spending time with my family, friends, and my adorable cat named Garfield. I also like to watch Disney movies, run, travel, and try out new restaurants!
This is my third semester as a UPM, and I am so excited to be working with Ms. Franks RDNG 371 class. I cannot wait to see what this semester holds!
My name is Haley and I'm a Junior 4th-8th Math and Science major with a minor in Mathematics. I've always had a passion for learning and a huge respect for teachers. In high school, I joined the Ready Set Teach program where I got to intern in local Prosper ISD schools and explore an assortment of courses. I also got to compete nationally in my school's Texas Association of Future Educators chapter. Between my experience in the program and my senior year job at the Reading Ranch tutoring center, I realized that I wanted to spend my career sharing my love for learning with my students.
In my free time, I enjoy reading, binge watching Parks and Recreation, and traveling to mountainous areas. I'm a member of Feminism for Aggies and I own a blue tongued skink named Jerry.
This is my second semester as a UPM and I'm excited to work alongside Ms. Yang in RDNG 372!
Howdy! My name is Kristen and I'm a Junior EC-6th grade education major from Cypress, TX. I hope to teach kindergarten when I graduate. I have a passion for reading and children's literature! I love Starbucks, traveling, and anything food related – I love to bake! I am looking forward to working with Mrs. Carter's RDNG 461 class.
Howdy! My name is Merari, and I am from Elsa, TX - a small town located in the Rio Grande Valley. I am currently a junior Interdisciplinary Studies major with a focus on 4th-8th-grade language arts and social studies, and I couldn't be happier. Being a teacher has always been what I wanted to do because, from a young age, I understood what an incredible difference educators can make.
In my spare time (which doesn't happen very often), I like to watch movies, go shopping, scroll through Twitter and Pinterest, read, and catch up on Netflix. Oh, and I also love spending time with my family (that's my brother and sister in the picture by the way)!
This is my second semester working as a UPM, and I am excited to see what this semester brings me in terms of working with Dr. Cassell and her INST 362 class. Thank you!
Howdy! My name is Heather Hall and I am a junior education major with a concentration in 4-8 math/science. After graduation, I hope to teach middle school science for several years before obtaining a master's degree and pursuing a principalship. This is my second semester as a UPM and I am very thankful for the opportunity to work with Ms. Jiang and her INST 362 class.
Aside from being a UPM, I am also a member of Hullabaloo Band, the official pep band of A&M volleyball and basketball. When I'm not busy with school stuff, I enjoy spending time with friends, playing video games, and doing anything outdoorsy. I also have a kitten named Lawrence Sullivan Ross (but he goes by Sully).
Howdy! My name is Sierra, and I am a sophomore here at Texas A&M. Ever since I was in kindergarten, I wanted to be a teacher. Years later, I am still pursuing that goal and am more excited than ever to go to school at A&M where I will learn to be the best teacher I can possibly be.
When I graduate, I hope to have a Bachelor's in EC-6 education and a Master's in counseling. My dream is to teach 2nd grade in my hometown, which is in Forney, Texas.
In my free time, I like painting, riding horses, writing, playing guitar, and trying all the flavors of snow cones at Bahama Bucks.
This is my first semester as a UPM, and I feel extremely honored to be working with Dr. Boettcher this semester for RDNG 461!
Hi friends!
My name is Chae Kim and I am currently a third year Education major focusing on 4th-8th Language Arts/Social Studies. This is my first semester as a UPM and I couldn't be more excited to work alongside such great future educators. I enjoy exploring coffee shops, eating food from countries across the world, and just having great conversations with everyone I meet! I hope to teach Social Studies at an inner-city middle school campus in Houston and build relationships with students, parents, and other teachers.
This semester, I am working alongside Mrs. Ribeiro's INST 362 class and I am beyond thrilled to have this opportunity. Let's make it a great school year!
Hello All!!
My name is Emily, and this is my first semester participating the UPM program. I am a junior in the College of Science majoring in Mathematics and minoring in secondary STEM education through the aggieTEACH program. I am from San Antonio, Texas and am a die-hard Spurs fan. I love running, riding my bike, and making up fun recipes in the kitchen. I have included two photos above with each of my parents. My mom and dad have taught me the importance of hard work, dreaming big, and loving others well. I would not be the individual I am today if it were not for their guidance, grace, support, and love. I am excited for the upcoming semester and cannot wait to see all that I will learn.
Howdy! My name is Kailey and I am so excited to begin my second semester as a UPM! This is my senior year in the College of Education and am studying Ec-6th. I plan to do my student teaching next semester most likely in the Cypress area. I love spending time with my family, reading, traveling, and playing with my puppy.
This semester I am working alongside Ms. Jiang in INST 362. I look forward to having a great semester!
My name is Leah Hale and I am a senior Interdisciplinary Studies 4-8 major with a concentration in English Language Arts and Social Studies. I am from the Clear Lake/ Galveston area, and I plan to work somewhere around Houston when I graduate. I love history, so I hope to one day teach in a 5th grade Social Studies class! I enjoy traveling, learning languages, and reading, so I have to recommend 1984 by George Orwell, of course.
This is my first semester as an Undergraduate Peer Mentor, so I am looking forward to working with Dr. Matthews in her Reading 372 class!
Howdy! My name is Tiffany Gambrel, and I am a junior Interdisciplinary Studies major (EC-6) from Winnsboro, Texas. I am currently pursuing a minor in Spanish, and I also hope to attain a Master's degree in either administration or counseling. Upon graduating from Texas A&M, I plan to teach at a low-income school. The importance of empowering the next generation cannot be understated, and I am thrilled to enter the field of education in order to transform children into leaders.
In my spare time (which rarely occurs) I enjoy dancing, painting, reading, and running. Another passion of mine is mission work. During the summer, I work at Camp Deer Run, and I recently returned from a mission trip in Africa. This is my third semester as an Undergraduate Peer Mentor. Working alongside Ms. Middlebrooks in RDNG 371 will be a thrill!
Fall 2016 UPM Program Coordinator
Howdy! My name is Dr. Matthews, and I'm thrilled to serve as the UPM program coordinator. This is my third year at Texas A&M, and though I've been away for awhile, Texas is a familiar place because most of my family lives within a few hours of College Station. We are very connected to the military which means we've been fortunate to live and travel to some exciting places. While I still love to travel, being an Aggie professor is definitely a huge, joyful part of my life.
Our UPMs are very special people who positively impact the lives of Aggie pre-service teachers in profound ways. They serve as our best ambassadors of writing, and I hope you will seek them out (EDCT 210) and allow them to support your writing process.


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So I'm 23yrs old and I'm really tall and really thin...but I grew really quickly when I was young and because of that I have tiny thin little white stretch marks on the back of my legs, behind my knees...i hate them so much. I really like this guy, he's really attractive and things I'm beautiful. but he's never seen me in shorts or anything and I'm scared he won't like me because of them. Like I said, they're not terrible...a lot of people tell me they aren't even noticeable. But because he'll be a lot closer to me than most people, he's gonna see them. Guys...do stretch marks really bother you?
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Neutrophil elastase can contribute to the pathogenesis of increased airway reactivity and excess mucus secretion in many pulmonary diseases. Ten nanomolar human neutrophil elastase (HNE) effectively empties airway serous cells, raising the question of why HNE is not equally effective at emptying mucous cells of their stored mucin because total release of mucin granules is not seen in postmortem examination of even the most severe disease. To better resolve the mucus secretagogue action of HNE, we measured secretion of mucinlike glycoconjugates (MGCs) released from freshly isolated swine tracheal submucosal gland cells in fractions of the superfusate acquired every 2 min. Six to fifty nanomolar HNE released a fixed quantity of MGCs at an increasing rate with increasing concentrations of enzyme, an action consistent with the release of cell surface mucinlike molecules. The polycation poly-l-lysine (1 μg/ml) released a similar transient of MGCs. A steady-state doubling of MGC rate of release was seen as long as 100 nM HNE was present, but this stimulus represented less than a 1% release of stored MGCs/min and was consistent with release of mucin vesicles from cell stores. Both actions of HNE were inhibited by the specific inhibitors L-680833 and DMP-777 but not by 30 μM erythromycin. Therefore, HNE release of MGCs from tracheal submucosal glands is limited by both the fixed quantity of the MGCs in the transient pool and by the small steady-state response to the higher concentrations of enzyme.
- swine
- erythromycin
- chronic bronchitis
- cystic fibrosis
- trachea
- secretion
- inflammation
- leukocyte elastase
- serine proteinase inhibitors
- asthma
increased secretions have been a hallmark of airway disease since the time of Hippocrates' Prognosis, and they contribute to the associated morbidity and even mortality of the common cold, asthma, chronic bronchitis, and cystic fibrosis (37). Thus it can be easy to lose sight of the beneficial characteristics of airway secretions (19). Fluid secretion by the airway epithelia serves to support a blanket of mucus and to continuously sweep clean the airways and glandular structures with a sterile liquid (43). Watery secretions from serous glands include potentially bacteriostatic and bacteriocidal proteins such as lysozyme, lactoferrin, secretory IgA, and peroxidase (1). The mucins secreted by the surface and submucosal mucous cells serve to trap airborne particles and move them up the airways by mucociliary transport (42). In addition, mucins specifically bind surface adhesins of bacteria such as Staphylococcus aureus and so are additionally effective at trapping these pathogens in the airway (40). Physical stimuli can act directly to increase airway secretions and mucin release as can neurogenic stimuli and products of inflammatory cells such as histamine and certain secreted proteins and proteinases. Additionally, certain lipid mediators, serum proteins, and bacterial products can also stimulate mucin release (reviewed in Ref.32). However, there are limits to the quantity of mucin that can be safely released because excessive airway mucus can limit airflow and prevent ventilation of entire lung segments (37).
Cholinergic stimulation of mucin release is well adapted to this constraint because a brief stimulus, such as that administered by a cholinergic nerve, increases the rate of secretion >10-fold, but sustained exposure releases far less because a profound tachyphylaxis develops (8). By contrast, human neutrophil elastase (HNE), a known mucus secretagogue (4, 18, 25, 28), could be a potentially dangerous stimulus based on the observation that this enzyme effectively empties the contents of another submucosal gland cell, namely the serous cell (35). Serous glands do not pose the same danger as mucous glands because they generate a watery discharge; however, the sudden release of essentially all the stored airway mucins would certainly cause massive airway plugging and a prompt death.
Therefore, we sought to quantitatively examine the time course of the response of tracheal submucosal gland cells to HNE (7).
Animals and tissue preparation. The experimental protocols for this study were approved by the Institutional Animal Care and Use Committee of the University of Mississippi Medical Center (Jackson, MS) and were carried out according to the Guide for the Care and Use of Laboratory Animals from the National Institutes of Health and the guidelines of the Animal Welfare Act. Swine were chosen as the animal model because of the similarity of airway glands in swine and human tracheae (11).
Male weanling swine (Yorkshire), 5–15 kg, purchased from local suppliers, were anesthetized with isoflurane and exsanguinated by severing the abdominal aorta and vena cava. The trachea was removed, washed with warmed normal saline, and stored in warmed Krebs-Henseleit: 110 mM NaCl, 2.0 mM KCl, 1.0 mM CaCl2, 2.5 mM NaHCO3, 0.1 mM NaH2PO4, 11 mM glucose, and 5 mM HEPES. The luminal surface of the trachea was scraped with the edge of a scalpel blade and rinsed with buffer to remove surface epithelia. Full-thickness strips of epithelium were dissected from the trachea and weighed. All subsequent steps of cell isolation and superfusion used medium 199 (M199; Sigma) plus 20 mM HEPES, 32 mM NaCl, and 1 mM 2-mercaptoethanesulfonic acid (MESNA). MESNA replaces dithiothreitol as a mucolytic agent. The measured osmotic pressure of this solution was 328 mosM.
Isolation of submucosal gland cells. The gland cells were obtained by enzymatic digestion with 0.36 mg/ml collagenase (type XI; Sigma) and 0.09 mg/ml DNase (type II, derived from bovine pancreas and low in chymase, protease, and RNase; Sigma) in M199 that was fortified with an additional 4 mM MESNA (8, 44). The tissue was continuously stirred for 2.5 h (Wheaton Cellstir), with additional enzymes added hourly. The suspension was filtered (70-μm strainer; Falcon 2350), and the cells were layered onto a discontinuous, prewarmed Percoll density gradient (1.033, 1.045, 1.058, and 1.084 g/ml) and spun at 500g for 15 min (1,200 rpm, 37°C; Beckman GPR centrifuge). Only cells from the most dense interfaces were used (1.045 to 1.058 and 1.058 to 1.084 g/ml); these cells were counted with a hemocytometer, diluted to 50 ml, and maintained at 37°C until loaded into the superfusion apparatus. Cell viability was determined by trypan blue exclusion.
Perfusion manifold. This manifold was designed to continuously perfuse cells supported on a polysulfone filter with a solution that was primarily derived from a central reservoir but that was additionally augmented with a choice of control or test solutions. Effluent was then collected in a fraction collector for later analysis. All pumps, tubing, filters, and the fraction collector were contained in a Plexiglas chamber warmed to 37°C (CN 9000 temperature controller, Omega Engineering, Stamford, CT).
Specifically, submucosal gland cells were loaded onto 13-mm disposable filter devices (0.45-μm pore size, polysulfone medium; Whatman, Clifton, NJ). One limb of a mixing tee (Upchurch Scientific, Oak Harbor, WA) was supplied with 0.25 ml/min of M199 by a 10-channel peristaltic pump (Ismatec 78001-40, Cole Palmer Scientific, Chicago, IL) from a central reservoir that bubbled the solution with O2. The reservoir was kept full by an auxiliary peristaltic pump (Ismatec 7331-10, Cole Palmer Scientific) that drew M199 from a storage bottle. The second limb of the mixing tee was supplied with a 50-fold concentrated solution from a glass syringe (1 ml; Hamilton, Reno, NV) resiliconized specifically for each experiment (Prosil 38, PCR, Gainesville, FL); the syringes were driven at 5 μl/min, or the rate of the M199 flow, by a multichannel syringe drive (K. D. Scientific model 220, Stoelting, Wood Dale, IL) that was modified to accept 20 individual syringe barrels. Diagonal flow valves (Upchurch Scientific) were selected between the test and control banks of syringes so that one or the other was always directed to the mixing tee while the remaining solution was directed to waste. The filter devices were located immediately after the mixing tee, and the effluent was collected by a fraction collector (Isco Retriever III, Isco, Lincoln, NE).
Inactivation of elastase. Methoxysuccinyl-Ala-Ala-Pro-Val chloromethyl ketone (CMK) (30) was the specific HNE inhibitor used to prevent the proteolytic degradation of mucinlike glycoconjugate (MGC) that is known to be caused by HNE (20); 50 μl of 220 μM CMK were added to each collection tube before the experiment. The final concentration of CMK was 20 μM after the collection of 500 μl of M199 effluent, or a 200-fold molar excess. Thus HNE was inhibited as soon as it was collected from the perfusion apparatus. Likewise, all blanks and standards were made up to 20 μM CMK.
Assay. Mucous glycoprotein was quantified by an enzyme-linked lectin assay (44), with Dolichos biflorus lectin (Pierce Chemicals, Rockford, IL) used to specifically detectN-acetyl- d-galactosamine (α-d-gal-NAc) residues (24). Mucous proteins characteristically have α-d-gal-NAc residues, but membrane O-glycans such as glycophorin and leukosialin also have such residues; for this reason, the α-d-gal-NAc residues detected in this assay are termed MGCs. Horseradish peroxidase was the conjugated enzyme, and 3,3′,5,5′-tetramethylbenzidine (Pierce Chemicals) was the substrate used in this assay. The optical densities were read at 450 nm (Rainbow microtiter plate reader; SLT-Tecan, Research Triangle Park, NC).
Chemicals. HNE, purchased from Elastin Products (Owensville, MO), was purified from leukocytes derived from purulent sputum; the enzyme preparation was free of cathepsin D, myeloperoxidase, and lysozyme and was >95% pure by SDS-PAGE. The specific HNE inhibitors L-680833 and DMP-777 (also termed L-694458) were gifts from Dr. Robert Vender (Dupont Pharmaceuticals, Wilmington, DE). CMK was purchased from Bachem Bioscience (King of Prussia, PA). All other reagents were obtained from Sigma (St. Louis, MO).
Experimental protocols. In each test, 0.2 × 106 cells were loaded onto the filter and equilibrated by perfusion with M199 for 1 h, and then fractions of perfusate were collected according to test protocols. Distilled water was perfused during the concluding 6 min of the protocol to lyse the cells and release all cell contents; the MGCs in these fractions defined the total glycoprotein stores remaining at the conclusion of the experiment. Aliquots (50 μl) of the perfusate were pipetted into quadruplicate 96-well titer plates immediately after the experiment for later analysis by enzyme-linked lectin assay.
Statistical analyses. Values are means ± SE. Differences between independent observations were determined by two-tailed unpaired Student's t-test, and differences from zero were determined by two-tailed paired Student's t-test (45); P< 0.05 was accepted as significant; otherwise, the results were deemed not significant. Multiple comparisons of test observations with the control period were made by Dunnett's test (45). The test for multiple comparisons among the results obtained for protocols performed simultaneously was by Tukey's honestly significant difference test (45). Decay rates were determined by linear least squares regression of the transformed data. Hill coefficients were determined by nonlinear least squares (Origin, Microcal Software, Northampton, MA).
Nanomolar concentrations of HNE released MGCs from tracheal submucosal gland cells in a controlled manner. Beginning at 6 nM HNE, a transient release of MGCs became apparent, with the rate of release returning to baseline values after ∼20 min (Fig.1 A). The decay rate of the transient became faster as the test HNE concentration was increased, with the response becoming significant by the second test fraction for 10 nM HNE and by the first test fraction for 30 nM HNE and above. Similarly, the transient was completed more quickly at the higher concentrations of HNE so that at 50 nM HNE, the MGC release returned to baseline after ∼10 min. At 100 nM HNE, the MGC transient did not decay to baseline but was followed by a plateau that persisted as long as the HNE was present in the perfusion solution (Fig.1 B); during this test period, significance was reached for the 1st through 4th and the 10th fractions (all comparisons to control value were tested by Dunnett's test).
The MGC cell content, as estimated by the sum of MGCs collected during lysis of the cells with distilled water at the conclusion of the experiment, was unaffected by the concentration of HNE employed during the test period: 3.0 ± 0.4, 2.5 ± 0.4, 3.5 ± 0.6, 3.8 ± 0.7, 3.3 ± 0.4, 2.9 ± 0.6, 3.4 ± 0.7, and 2.8 ± 0.5 fg/cell for 0, 1, 3, 6, 10, 30, 50, and 100 nM HNE, respectively (n = 8, 4, 4, 4, 8, 5, 5, and 5 experiments, respectively; not significant by Dunnett's test).
Baseline MGC secretion (Fig. 1 B) averaged 0.34 ± 0.01%/min (n = 5 experiments) when expressed as a percentage of total secretions. Although the baseline rate secretion varied, there was no systematic influence of the baseline rate on MGC secretion and the magnitude of the responses to HNE or inhibitor. The postcontrol period was similar: 0.37 ± 0.4%/min. The plateau of release caused by 100 nM HNE averaged 0.68 ± 0.2%/min, although the extra MGCs released during the first 8 min constituted 1.8% of the total stores.
The decay phase of the transient could be resolved in the case of 6 and 10 nM HNE, and the rates of decay were approximately proportional to the concentrations of the enzyme: 0.16 ± 0.01 s−1and 0.36 ± 0.02 s−1, respectively. Less direct measures of the HNE action showed a much steeper concentration dependence; for instance, the peak amplitude of the HNE-induced MGC release showed a very steep dependence on the enzyme concentration (Fig. 2 A), with a Hill coefficient of 3.4. An even more extreme concentration dependence was seen if the secreted MGC was integrated over the entire test period (Fig.2 B); in this case, the lowest concentrations of HNE showed no detectable MGC release, but in the range of 6–50 nM, all HNE concentrations released the same net quantity of MGCs.
MGCs could also be released by exposure to a simple polycation such as poly-l-lysine (a sample experiment is illustrated in Fig.3). Three cell isolates were tested with a 26-min perfusion of either vehicle, 1 μg/ml of poly-l-lysine, 10 nM HNE, or 100 nM HNE. In this series of experiments, 1 μg/ml of poly-l-lysine caused the release of approximately as much MGC as 10 nM HNE (0.14 ± 0.03 vs. 0.27 ± 0.13 fg/cell of MGC above baseline compared with vehicle; P > 0.05 by Tukey's test; n = 3 experiments) but less than 100 nM HNE (0.59 ± 0.09 fg/cell; P< 0.05 by Tukey's test; n = 3 experiments).
HNE-mediated MGC release was prevented by a cell impermeant β-lactam inhibitor of HNE proteolytic activity (Fig.4). The quantity of MGCs released during the test period was reduced from 0.22 ± 0.07 (n = 8 experiments) to −0.01 ± 0.02 (n = 4 experiments) fg/cell by a molar excess of L-680833 or to a value not significantly different from zero (P > 0.05 by paired Student's t-test).
DMP-777, a cell permeant β-lactam inhibitor of HNE, also prevented HNE-mediated MGC release (Fig. 5 A). Perfusing tracheal submucosal gland cells with 100 nM HNE plus 400 nM DMP-777 after pretreatment with DMP-777 alone resulted in the release of significantly less MGC during the test period than in the case of perfusion with 100 nM HNE alone, with no pretreatment, or in the control experiment, where vehicle alone was perfused (P< 0.05 by Tukey's test). The MGC released during perfusion with 100 nM HNE plus 400 nM DMP-777 was not significantly different from DMP-777 alone, no pretreatment, erythromycin alone, or zero (P > 0.05 by Tukey's test).
Polycyclic compounds did not generally alter HNE-evoked MGC release because the macrolide antibiotic erythromycin, reported to be particularly effective at reducing infection-related airway secretions (12), did not significantly alter the response to 100 nM HNE. Figure5 A illustrates the average response to 100 nM HNE with and without 30 μM erythromycin in experiments performed on two cell isolates (P > 0.05 by Tukey's test; erythromycin was present throughout the perfusion). Similarly, the response to 30 μM erythromycin alone or to the specific HNE inhibitor 400 nM DMP-777 alone during the test period did not differ from the control value (Fig. 5 B; P > 0.05 by Tukey's test).
HNE caused the release of MGC from swine tracheal submucosal gland cells in two phases, the first being a transient release of a fixed quantity and the second being a tonic release that lasted as long as the cells were exposed to enzyme. The early, transient release was first apparent at 6 nM, and this quantity of MGC was released increasingly rapidly over the range of 6–30 nM enzyme. Only with an order of magnitude increase in enzyme concentration was the tonically elevated release apparent.
Proteolytic enzymes as secretagogues. Certain bacterial enzymes contribute to the mucus hypersecretion that is a familiar component of pulmonary infections, notably the elastase and alkaline proteinase fromPseudomonas aeruginosa [from rabbit tracheal explants (22) and from human and feline airways (33)]. This activity has a degree of substrate specificity because other enzymes such as subtilisin, thermolysin, and pronase also release mucins, althoughStreptomyces caespitosus protease and collaginase do not (2).
Endogenous enzymes also cause release of MGCs. This type of secretagogue activity is present in certain enzymes derived from sources unlikely to stimulate airway secretion, such as trypsin and pancreatic elastase, both in animal models [hamsters (14)] and from tracheal epithelial explants [hamsters (22, 28)]. More importantly, secretagogue activity is also present in certain enzymes that are more likely to contribute to mucus hypersecretion in inflammatory diseases, such as the action of neutrophil elastase on hamster airway [tracheal explants (28) and surface epithelium in tissue culture (17)]. Similar findings were observed with neutrophil elastase and cathepsin G in feline and human airway cell cultures (25) and in ferret tracheal explants (21).
Thus it is not surprising that elevated levels of proteases are found in hypersecretory disease states. For instance, nasal secretions from individuals with common colds contained elevated neutrophil elastase activity as well as detectable α1-antitrypsin-elastase complex (13). Patients with severe asthma (9) or status asthmaticus (23) can also have elevated levels of neutrophils, neutrophil elastase, and mast cell tryptase as measured in bronchial lavage fluids, although patients with cystic fibrosis have the largest number of neutrophils and the highest levels of active neutrophil elastase of any disease group (reviewed in Ref. 6).
Additional support for the involvement of neutrophil enzymes can be derived from animal models of airway disease. Allergic dogs evidenced a delayed increase in free neutrophil elastase and serous secretions in isolated tracheal segments after antigen challenge, both inhibited by ICI-200355, a specific elastase inhibitor (36). Similarly, allergic sheep exposed to Ascaris antigen experienced a delayed bronchoconstriction that is correlated with influx of neutrophils into the airway, elevated elastase activity in bronchoalveolar lavage fluid, and a diminished tracheal mucus velocity, all of which can be attenuated with the serpin α1-antitrypsin or ICI-200355 (29).
The general involvement of neutrophil- and mast cell-derived proteases in asthma and chronic lung disease has been reviewed recently (15).
Elastase-mediated release of surface mucins. The initial study (3) that examined the structural consequences of instilling HNE in hamster airways described two types of acute changes. The first was an alteration in the appearance of the cell membrane in nonciliated cells, and the second was a decrease in the fraction of the surface cells that were granulated, a loss that rebounded over the next 16 days, so that the final epithelium was greatly enriched in mucous cells. Subsequently, a study (4) of radiolabeled glycoconjugate showed that exposure to neutrophil elastase caused a decrease of radiolabel at or near the surface of hamster tracheal epithelia.
Biochemical studies have identified a characteristic pool of mucins localized on the surface membrane of hamster airway cells that is released by neutrophil elastase, ostensibly because HNE is acting as a proteinase (17), much as it does with three other membrane-bound sialomucins: leukocyte CD43 and PGSL-1 and platelet GPIb (31). Alternatively, the mucin release may not be due to the proteolytic action of HNE at all, just as certain bacteriocidal actions of HNE require no active catalytic activity (10). One way this might occur would be due to the highly basic nature of the HNE molecule, which has an isoelectric point of 10.6 and a large number of arginines and lysines exposed on the molecular surface (39). Thus HNE might act as a polycation and salt out peripheral proteins associated with the cell membrane through ionic interactions as can be done by nonspecific elevations of ionic strength alone (18).
The initial transient release illustrated in Fig. 1 is consistent with release of a small pool of external mucinlike molecules (17) because a fixed quantity of MGC was released regardless of HNE concentration. The observed time course is also consistent with the observation by Kim et al. (18) that 1.5 min of exposure to 25 μg/ml of elastase (∼1 μM) released 43% of the surface mucins from cultured hamster tracheal epithelial cells.
However, exposure to 1 μg/ml of poly-l-lysine, a polycation, did release a transient of MGC (Fig. 3). It is unlikely that HNE was acting simply as a polycation because the inhibitor L-680833 effectively blocked the HNE-induced transient MGC release. L-680833 binds tightly in the reactive cleft of HNE, opposite the girdle of basic amino acids that stretches around the back of the enzyme, away from the catalytic site (5), and so it should have no direct effect on those cationic charges. Thus the HNE-induced MGC transient is most likely a membrane-bound mucin proteolytically cleaved from the tracheal mucus gland cell surface.
Little HNE is required to release the cell surface mucins. The initial rate of MGC release would be the most direct measure to use in a concentration-response curve, but this portion of the MGC release curve was not resolved with the current method. Next best is the rate of decay of the MGC transient, and this could be resolved for 6 and 10 nM enzyme, in which case the rate of decay increased in proportion to the enzyme concentration. Figure 2 A plots a more indirect measure of the concentration-response curve, namely the relationship between HNE concentration and peak MGC release, which shows a steep relationship with a half-effective HNE concentration of 6.0 ± 1.7 nM. The most indirect measure is summarized in Fig. 2 B, where the integral of MGC release increases vertically between 3 and 6 nM HNE, with a poorly resolved half-maximal concentration (3.9 ± 20.0 nM). Figure 2 B is more comparable to published literature, where the 30-min sum of release is typically the sample analyzed. For instance, the release of serous cell contents summed over 30 min is first detected at 1 nM and is essentially complete at 10 nM (35). Similarly, the release of radiolabeled glycoconjugate from feline tracheal gland cells was detected over a range of 50–500 ng/ml (1.7–17 nM) HNE (25). Thus it is the concentration dependence of the HNE-mediated transient release that is consistent with reported release of serous cell contents and of radiolabeled glycoconjugate from feline tracheal gland cells.
Elastase-triggered mucin exocytosis. Neutrophil elastase also causes exocytosis directly. As visualized by videomicroscopy, 1 μM HNE causes an increased number of secretory vesicles to cluster beneath the cell membrane of tissue-cultured human tracheal gland cells (MM39 cells) (16) and to be released over an 8-min period of observation (26).
The sustained plateau of release illustrated in Fig. 1 B is consistent with quantal release of internal stores of mucin (26) because the rate of release remains constant for the duration of the exposure to HNE. Even though the rate of MGC release doubles, this represents the loss of <1% of stored MGCs/min, a rate that is much smaller than the 80% release of serous cell contents caused by HNE over a 30-min period (35). It is not possible at this time to determine whether HNE is less effective as a secretagogue in mucous cells relative to that in serous cells or if a separate inhibitory mechanism limits the potentially fatal release of mucous cell contents.
Specificity of elastase action. Some actions of neutrophil elastase are highly nonspecific, such as tissue damage (15), although other actions are so specific that similar effects are not seen even with the closely homologous proteases cathepsin G and proteinase 3, such as the release of the sialomucin CD43 from leukocytes (31). In the case of serous cell exocytosis, the mechanism of action is unknown (34).
The concentrations of HNE used in the present study were adequate to cause no more than release of surface MGCs and a modest increase from the baseline rate of secretion. Cell lysis at the conclusion of the experiment showed that there was still a large pool of MGCs unaltered by HNE exposure during the test period, indicating that the cells remained viable. In fact, the concentrations of HNE used in this study were almost two orders of magnitude less than those seen in sputum from cystic fibrosis patients (6).
Inhibition of elastase by L-680833 prevented the release of MGCs. By design, L-680833 is highly specific, inhibiting primate but not dog or rat neutrophil elastase (5). However, it is conceivable that L-680833 and DMP-777 might have nonspecific effects on mucus secretion, particularly because the macrolide antibiotic erythromycin has been reported to inhibit glycoconjugate secretion from human airways in vitro (12) and to inhibit chloride secretion across canine trachea (38). However, in these experiments, 30 μM erythromycin had no effect on baseline or 100 nM HNE-induced MGC release. Thus it is unlikely that either L-680833 or DMP-777 acts by an erythromycin-like effect to inhibit HNE action.
Conclusion. With good time resolution, it is possible to see two distinct patterns of HNE-induced MGC release. HNE acts at low concentrations to release a fixed quantity of MGCs, possibly by ionic interactions at the cell membrane surface. At higher concentrations, HNE causes a tonic release of MGCs, likely from cell store vesicles, at <1% of stored MGCs/min, a rate that does not imperil the patency of the airways.
We thank Lester Donald for skilled technical assistance. We are grateful to Dr. Marcy Petrini for reading earlier versions of the manuscript and Dr. Robert Vender (Dupont Pharmaceuticals, Wilmington, DE) for generous gifts of human neutrophil elastase inhibitors.
Address for reprint requests and other correspondence: T. M. Dwyer, Dept. of Physiology and Biophysics, Univ. of Mississippi Medical Center, Jackson, MS 39216-4505 (E-mail:tdwyer{at}physiology.umsmed.edu).
This work was supported by a Henry Harald and Eunice Albritton Memorial Research Award from the Mississippi chapter of the American Lung Association, National Institute on Drug Abuse Grant DA-05094, and National Heart, Lung, and Blood Institute Grants HL-11678 and HL-51971.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
- Copyright © 2000 the American Physiological Society


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Clouded in secrecy, DOMFIL has been organizing an amazing event! We are arranging a trip to Kolmården Wildlife Park, with activities throughout the day on the 29th and 30th of April with an overnight stay at the park! Signing up is exclusive to Ph.D students, research engineers and research assistants who are members of DOMFIL!
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Improving my howa?
Just bought a howa m1500 chambered in .223. What are some mods I can do or have a local gunsmith do to improve the accuracy of this rifle? Please tell me the mods and an estimated price. Want to use this gun mainly for varmint and target shooting.
Before you do anything to it, have you even taken it out and shot it yet to see where it's at on accuracy ???
There are many things you can do to accurize a rifle, depending on the $$$$$ you have in your wallet.
The two most basic that will help any rifle are stock bedding and a good trigger.
Hard to say what will need to be done to it without seeing targets shot with good ammo. I would not want to steer you in the wrong direction and spend $$$ that you don't need to. It's like asking a doctor over the internet, whats wrong with my big toe when it hurts......
There are a few things that don't always automatically help-but don't hurt either. The Howa don't have a "floating" bolt head (locking lugs) so lapping the bolt should help.
A good trigger won't make your rifle itself shoot better-but it WILL enable you to shoot it more accurately.
Glass/pillar/aluminum block bedding will enable your rifle to maintain zero better, even through disassembly and reassembly.
Proper scope mounting is MUCH more important than commonly believed-that includes lapping the rings in the case of steel rings to eliminate damage to the scope.
See the sticky thread at the top for more detail.
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Alan Woods said; "I'm stoked that we still have the support of many of the companies that supported us when we won the British Cycling No.1 Team awards for three years straight, back in 2006-2010. I am really looking forward to seeing the riders out on the track with their finished bikes and kit and I'm
Support your local scene: Flame Trails Jam 2017
Having something to ride nearby is magic. It might take forever to get a spot or a ramp going, but by showing the city that there is a scene that needs a place to ride, you can get things done. The hard part is not to give up. These plans take longer than you want, always. In the meantime you can gather more riders to get behind you. In a world where more and more kids spend time behind the game consul, TV, ipad or with a phone in their hand, it's time to let them play outside. Thankfully we got a dirt spot in Brandevoort and a concrete park right next to it. If I open the front door I can almost see it, it's that close.
Once you have your spot it needs to be maintained. That falls back in your lap. The concrete park doesn't need much effort. An outdoor dirt spot however does need some love from time to time. Next to that, throwing a jam from time to time is a good idea. It gets people motivated to get the jumps and turns back in shape and it brings the scene back together. For people who have to come from far, they know the trails are in good shape for a nice session that day. Also the local community gets to see what those 'piles of dirt' are actually for.
The annual Flame Trails jam took place on 9 April on the sunniest day of the year. It was an afternoon full of dirt jumping with little goodies for the riders that were supplied by the supporters of the jam (Haro Bikes/TwinAir). Riders were pushed to take it a little further than normal and basically everyone
Lekkers van Beckers at the 2017 Mini FATJAM
It was time to dust off the BMX bike for a session at the Sugar Hills because the Mini FATJAM was on the program. For a bunch of people it is that way. And that's fine. It shows that the Mini FATJAM is a reason to go ride again, together with those who think the same way. The jumps had been prepared for the same reason, because the Mini FATJAM was coming up. The jam gets people together and back on the bike and also this year we had support from Vans, Paul's Boutique, Haro Bikes so we could give out goodies to those who took the effort to come over to Aarle-Rixtel and put a few laps in. Also, for the first time in FATJAM history, we had Beckers as a sponsor of the event. They make the best Frikandellen (way better than Mora) and everyone present could get himself a
Haro Race Team 2017 by Haro Bikes UK
The 2017 Haro Bikes UK Race Team got together for a weekend in the midlands to hit up a fair few race & pump tracks on their freshly pimped up Haro race bikes with the help of some the best components in the game courtesy of BOX BMX, collect their fresh 2017 O'Neal racing kit and do some training before the season kicks off.
Simple Session is all about making awesome memories.
Video by Dmitri Shushuyev
New Spring 2017 Bike Collection From 100%
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Complementing the new riding apparel are new designs of the popular Aircraft MIPS helmet as well as the brand-new Status helmet. The Status incorporates design cues from the championship winning


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Fraternity Crew Neck Sweatshirt with Sewn On Letters
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As we move past the mid-point of April, we are now looking at the optimal time for another fantastic American shad fishing season on the Delaware River! This is indeed THE time of the year in the sections of the river that I fish for the annual American shad run.
There's just something truly special about a big female American shad fresh from the ocean caught on one of my fly rods, or on an ultra light baitcasting rod, or on a 8′ long 'whispy soft' all fiberglass spinning rod… that makes for an absolutely incredible fishing experience. Let's not ignore the male of the species…. those smaller, yet much more acrobatic males, are a blast too!
I hope that you can make it out with me to enjoy this great fishing opportunity over the next month or so. Check out my 'Press' tab for some fantastic video of this great sport!
If you want to pursue something else, then there are plenty of other types of trips Fishin' Fun Charters runs…. including walleye and smallmouth fishing on the Delaware River, along with muskie, largemouth bass, and trout/salmon trips at various lakes in NJ.


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Handwritten notes in the Rev. James D. Foley's file indicate that when the woman collapsed from an apparent drug overdose, Foley got dressed, left and returned an undetermined time later before calling 911.
The woman later died, but it is not clear if it was a result of the overdose. Police in Needham, where the documents indicate the woman lived, said they have no record of it. The state Attorney General's office is also examining the documents.
The notes, released Thursday, were among 11,000 documents that the archdiocese was ordered by a judge to hand over to attorneys representing dozens of alleged victims of church sex abuse.
When the details on Foley came to church's attention in 1993, the documents indicate, Cardinal Bernard Law and Bishop John McCormack ordered Foley to resign his post at Our Lady of Fatima Church in Sudbury and to undergo treatment at a residential center in Canada.
Foley's history, which includes allegations of at least one other relationship with a woman, appears to have deeply troubled Law.
On one occasion, McCormack wrote: "Cardinal Law thinks that (Foley) should not be in pastoral ministry due to potential scandal. His remark is that this man should spend his life in a monastery doing penance."
After his release, however, the archdiocese in 1994 agreed to let Foley live at a rectory and to celebrate Mass while continuing his therapy, although it barred him from performing other ministry duties or having anything to do with "vulnerable women."
Foley was placed in a parish in 1995 and has since been appointed associate pastor.
An initial review of the documents do not show that any further allegations of sexual impropriety surfaced against Foley. However, the order restricting his ministry duties was renewed as recently as 1998, the documents show.
In an interview with New England Cable News and The Boston Globe, Foley initially insisted "my record in the archdiocese is above reproach. There's never been a single allegation. I have no idea where this kind of wild speculation comes from."
But then Foley was confronted with a 1994 letter he wrote to McCormack, in which he said he had gotten a call saying if he ever tried to contact the children of the deceased woman, an investigation of her death would follow.
"It happened over 25 years ago and it is in the interest of no one to open that tragic story," Foley wrote McCormack. "I will regret to my dying day the circumstances but I cannot turn back the clock nor bring back the dead. How can the church suffer scandal from an episode that will never possibly be revealed? Who will reveal it? The Cardinal? Myself? A family member?"
Foley curtly responded: "This is something very personal, very confidential, very private. I don't think it's an issue for public hearing."
Foley did not return a phone message left at St. Joseph parish in Salem where he is associate pastor. Parish secretary Betty Richard said Foley had been terminated as of Thursday.
Archdiocese spokeswoman Donna Morrissey did not return several phone messages seeking comment.
Files released by the plaintiffs' attorneys on Tuesday focused on eight priests. Among the allegations: a priest beat his housekeeper and threatened alleged sex-abuse victims; another priest traded cocaine for sex with boys; and a third had sex with teenage girls studying to become nuns.
Thousands of other pages on more than 55 priests have yet to be made public by the attorneys.
The plaintiffs say the church failed to protect parishioners by ignoring the sex allegations and simply moving accused priests from parish to parish.
The files released Tuesday prompted renewed calls for Law to step down.
On Wednesday, the archdiocese Finance Council authorized Law to seek bankruptcy protection for the archdiocese to deal with the hundreds of sexual-molestation claims against priests. Law has not made a decision on whether to file for bankruptcy, and would have to get approval from the Vatican.
By Robert O'Neill


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|Conor MacNeill <co...@cortexebusiness.com.au>
|Re: "available" shouldn't actually load the class; just see if it's resolvable
|Tue, 09 Nov 2004 22:08:54 GMT
David Smiley wrote: > > I suggest the name "load" instead since that is the java vernacular for > what's happening. > > I also suggest that the next snapshot implementing this have it default > to "false" and we'll get a feel for wether this is a problem at that time. > Unfortunately that would not be backward compatible. If you want new behaviour, it needs to be explicitly enabled, IMHO. Conor --------------------------------------------------------------------- To unsubscribe, e-mail: email@example.com For additional commands, e-mail: email@example.com
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Jones was released on home incarceration in lieu of a $25,000 bond.
Two other men have also been charged with rape and sodomy
Chris Jones handcuffed and taken out of the courtroom. Our crew will have more info on WDRB News at 11:30. #WDRB pic.twitter.com/yVOZuDukzF
— Tamara Evans (@TamaraWDRB) February 26, 2015
Here are details from the Courier-Journal:
The warrant, signed Wednesday by Jefferson District Judge Katie King, says that one of the women was hospitalized Sunday and able to identify Jones as her assailant. One of the women is 19 and the other 20, according to the warrant.
A second warrant says Jones, along with two other people, forced a woman to have intercourse and oral sex. She also identified Jones as a U of L player, according to the warrant. She was taken to University of Louisville Hospital, where she was treated.
Those defendants have been arrested and are to be arraigned Thursday morning in Jefferson County Jail. Jessie Halladay, a spokeswoman for the Jefferson County Attorney's Office , identified them as Tyvon Walker and Jalen Tilford. Walker was charged with one count of rape and Tilford with one count of rape and one count of sodomy.
Complete Article
Defense attorney Rib Eggert asked that the University of Louisville be ordered to preserve video surveillance tapes, saying they will show Jones is innocent.
Chris Jones leaves courtroom in handcuffs. pic.twitter.com/vA1EU89WSI
— rickbozich (@rickbozich) February 26, 2015


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3642 Mourning Dove, Greenville MI, 48838
Sold Price:
2 beds , 1 Full baths
1,440 sqft
Status: Closed
Last Updated: 8/20/2017 2:25 PM
Description for 3642 Mourning Dove Greenville, MI 48838
Beautiful A-Frame home tucked in the woods! Home has been extremely well cared for and updated with new floor and wall coverings, trim and more. Brand New Hanson Roof with lifetime warranty and brand new high efficiency furnace. Updated kitchen overlooks rear deck, landscaping, and fire-pit area. Large 2+ stall garage with brand new automatic door openers. Property includes access to Private All Sports Perch Lake and all the great swimming and boating that goes with it. Lake Access is less than a minute walk from property. Close To Golf Course And Shopping And Yet Surrounded By Private Woods. Natural gas and super cheap utilities. Lot is made of 4 parcels. Hurry to show and immediate possession!!
Sold Price:
Sold Date:10/16/2015
Montcalm Twp
1 Full
1,440 (approx)
Listing Information
Montcalm Twp
Crawl Space
Other, Septic
Electric, Natural Gas, Telephone
School Information
Room Information
Butler Pantry
Interior Features
Dryer, Convection Oven, Range, Refrigerator, Washer
Window Air Conditioning, Ceiling Fan(s)
Gas Heat, Forced Air
Exterior / Lot Features
Detached Garage, Unpaved, 2 Car Garage
Deck, Patio
Lake, Recreation Facility, Unpaved Road, Wooded, Acreage
Driving Directions
M91 N of Greenville to Sidney Rd, W to Starling, N to Mourning Dove, E to property
Financial Considerations
Listing Price History
Greenville Real Estate
Greenville is located in Michigan. Greenville, Michigan 48838 has a population of 8,444.
The median household income in Greenville, Michigan 48838 is $31,122. The median household income for the surrounding county is $40,739 compared to the national median of $53,482. The median age of people living in Greenville 48838 is 34.1 years.
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Claudia Hoppe
An award-winning designer in her native Germany, Claudia Hoppe designs jewelry that's surprisingly simple and arrestingly complex. She is best known for taking the idea of a stack of uniform bangles and rhythmically repeating them, incorporating the empty space into a single bracelet that surprises all. When she adds a lacquered layer on the inside surface, she captures color just as disarmingly. Integrated clasps complete her paper-thin metal creations, creating eye-catching, wearable sculpture.
Sterling silver and red lacquer cuff bracelet.
By Claudia Hoppe
Sterling silver and yellow lacquer bracelet.
By Claudia Hoppe


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- The revenue growth came in higher than the industry average of 3.2%. Since the same quarter one year prior, revenues rose by 21.4%. This growth in revenue appears to have trickled down to the company's bottom line, improving the earnings per share.
- The net income growth from the same quarter one year ago has exceeded that of the S&P 500 and the Beverages industry average. The net income increased by 2.7% when compared to the same quarter one year prior, going from $208.75 million to $214.45 million.
- The current debt-to-equity ratio, 0.55, is low and is below the industry average, implying that there has been successful management of debt levels. Although the company had a strong debt-to-equity ratio, its quick ratio of 0.79 is somewhat weak and could be cause for future problems.
- The gross profit margin for COCA-COLA FEMSA SAB DE CV is rather high; currently it is at 51.35%. Regardless of KOF's high profit margin, it has managed to decrease from the same period last year. Despite the mixed results of the gross profit margin, the net profit margin of 6.47% trails the industry average.
- COCA-COLA FEMSA SAB DE CV's earnings per share improvement from the most recent quarter was slightly positive. This company has reported somewhat volatile earnings recently. But, we feel it is poised for EPS growth in the coming year. During the past fiscal year, COCA-COLA FEMSA SAB DE CV reported lower earnings of $4.28 versus $5.11 in the prior year. This year, the market expects an improvement in earnings ($4.66 versus $4.28).
Editor's Note: Any reference to TheStreet Ratings and its underlying recommendation does not reflect the opinion of TheStreet, Inc. or any of its contributors including Jim Cramer or Stephanie Link. The Consumer Goods sector as a whole closed the day down 0.2% versus the S&P 500, which was up 0.1%. Laggards within the Consumer Goods sector included Bridgford Foods ( BRID), down 1.6%, Seneca Foods ( SENEB), down 3.4%, Entertainment Gaming Asia ( EGT), down 1.6%, Fuwei Films (Holdings ( FFHL), down 2.4% and Koss ( KOSS), down 4.3%. TheStreet Ratings Group would like to highlight 3 stocks that pushed the sector lower today: Coca-Cola Femsa SAB de CV ( KOF) is one of the companies that pushed the Consumer Goods sector lower today. Coca-Cola Femsa SAB de CV was down $2.66 (2.4%) to $110.14 on light volume. Throughout the day, 25,787 shares of Coca-Cola Femsa SAB de CV exchanged hands as compared to its average daily volume of 71,600 shares. The stock ranged in price between $110.07-$114.00 after having opened the day at $113.21 as compared to the previous trading day's close of $112.80. Coca-Cola FEMSA, S.A.B. de C.V., a franchise bottler, produces, markets, sells, and distributes Coca-Cola trademark beverages. Coca-Cola Femsa SAB de CV has a market cap of $23.8 billion and is part of the food & beverage industry. Shares are down 7.4% year-to-date as of the close of trading on Tuesday. Currently there is 1 analyst who rates Coca-Cola Femsa SAB de CV a buy, 1 analyst rates it a sell, and 5 rate it a hold. STOCKS TO BUY: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12 months. Learn more. TheStreet Ratings rates Coca-Cola Femsa SAB de CV as a buy. The company's strengths can be seen in multiple areas, such as its revenue growth, increase in net income, largely solid financial position with reasonable debt levels by most measures, expanding profit margins and growth in earnings per share. We feel these strengths outweigh the fact that the company has had lackluster performance in the stock itself. Highlights from TheStreet Ratings analysis on KOF go as follows:


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The Graduates 2007 DVDRip x264
The Graduates 2007 DVDRip x264 AC3 Yuki Iwata
AKA: Lemon no koro / 檸檬のころ
Director: Yuki Iwata
Writers: Yuki Iwata, Miho Toshima
Genre: Drama
Runtime: 115 min
Language: Japanese
Subtitles: English (embedded .srt, plays by default)
Source: VAP R2J DVD9 (Thanks to ryooki @ ADC for the DVD)
IMDb: www.imdb.com/title/tt0991242
AsianWiki: asianwiki.com/The_Graduates
Synopsis: Five seniors at a rural high school tries to come to grips with the impending graduation and all the changes that will come for each of them soon after. Aspiring rock journalist Kei loses confidence in her chosen path when her best friend gets published before her, but gets a boost when rocker Kazuya compliments her work and she starts developing feelings for him. Takumi deals with the unrequited love of Kayoko, who, in turn, slowly comes to realize that she's going to have to break up with her boyfriend Tomizo when she leaves for a Tokyo university in spring.
Based on Toshima Miho's popular novel, Lemon no Koro (a.k.a. The Graduates) is a bright coming-of-age film that brings viewers back to those high school years. Crushes, first love, secrets, insecurities, hanging out with friends... If there was a taste to describe high school, it would be that of the lemon - tart and memorable. Director Iwata Yuki vibrantly captures "the time of lemons" in this tender youth anthem to life, love and friendship. The film features a refreshing cast of rising young stars including Eikura Nana (My Sister, My Love), Emoto Tasuku (Freesia: Bullets Over Tears), Tanimura Mitsuki and Ishida Hoshi from Canary, and Hayashi Naojiro of Hirakawachi Icchome in his acting debut.
These files can all be downloaded at Usenet.
www.oboom.com/8JCRZR3X/Lemon.no.koro.2007.DVDRip.x264.AC3.mkvGet 14 Days for free Access to USENET. Free 300 GB Unlimited downloads!


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Dr. Suzanne Goh MD
- Child Neurology San Diego, CA
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Dr. Suzanne Goh, MD is a Doctor primarily located in San Diego, CA, with another office in New York, NY. She has 10 years of experience. Her specialties include Child Neurology and Neurology. She speaks English.
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Peter Turner Photographer
Ozzie ReyesHair Stylist Male New York, New York, US
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I have been doing hair for 20 years.... Hair is my Passion. I specialize in all types of hair. I'm always looking for new clients...and to meet new and exciting peopl. If you need your hair done...call me.... I am a photo shoot specialist.
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Modern Salon, Vibra, American Salon, Salon City, CHI Magazine and Passion Magazine... are a few magazines that I have been published in. Be Magazine
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