text:
"Thank goodness for nurses."
About: Airedale General Hospital Airedale General Hospital Keighley BD20 6TD
Posted by Celia Normington
Visited A & E on Sunday 12th October at 5pm having gone over on my ankle whilst out walking. I was admitted within 10 minutes and given a wheel chair as I couldn't walk and assessed 15 mins later and given painkillers. After half an hour called for x ray, so far fine. Waited another 3 hours to be seen but that's almost become an unacceptable 'norm' these days and it was very busy. In terms of cleanliness, there were soiled dressings on the floor of the assessment room and in the corridor. When I saw the doctor who confirmed no broken bones but then simply printed out a leaflet, told me to put frozen peas on it and said bye! I was in there for no more than 5 minutes. It was only thanks to the intervention of a nurse who saw my husband trying to help me, that I was given a splint and crutches. Still in agony several days later I saw my GP who was surprised that Airedale didn't give advice or a follow up appointment. The physio at the Coronation Hospital confirmed what I had derived from the internet that I suffered a severe sprain and the ligament is almost certainly torn off the bone and I will need to have a scan when the swelling has gone down enough. Overall the staff at Airedale were great, working in difficult circumstances with building work and too many patients in relation to staff numbers, but considering the pain I was in and the obvious injury the dismissive nature of the doctor's assessment was unacceptable. Recovery from this injury will take months and it is only because I looked for information on the internet that I have started that process.
Response from Airedale General Hospital 2 years ago
We are sorry that you weren't happy with some of your care and experience. We would like to discuss your concerns with you and urge you to contact our Patient Advice and Liaison Service (PALS) on 01535 294019.
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Movies: comedy and action mostly. Some good ones off the top of my head are Clerks, The Dark Knight, Dr. Horrible's Singalong Blog, and Gran Torino, but my movie tastes are more defined by what I don't like, which is basically most movies that are described as "Inspirational". Also, I love good standup. Mitch Hedberg, Eddie Izzard, Louis CK, Tim Minchin, and Steve Hughes are my current favorites.
Shows: HIMYM, Sherlock, Community, Brooklyn 9-9, Doctor Who, Chuck, Babylon 5, Farscape, Burn Notice, Bones, Game of Thrones, Buffy, Firefly, and every other Joss Whedon TV show.
Books: Hitchhiker's Guide to the Galaxy, 1984, Brave New World, Watchmen, His Dark Materials (The Golden Compass Trilogy), The Abhorson Trilogy, Ender's Game, Dune, most Heinlein
Food: Food. all of it. (minus horseradish/wasabi)
If you think chatting over drink or a meal is a way better way to get to know someone than yelling at them over club music.
If you think that blues dancing is sexier than grinding.
And especially if you think it's a shame that people don't smile at each other on the streets and subways of NYC.

subset: commoncrawl


text:
Dear Lord Jesus, please help to pay off my debt. My debt is so heavy that I cannot live as the way I used to live - debt free. Father, please help me to find a way to pay off my debt and help me to be released from the bondage of my debt. I truly can't bear to be blacklisted anymore. Please forgive me as I was foolish in my financial affairs and did certain wrong things. I'm very sorry & plead with you for a miracle & I firmly believe in you. Thank you Jesus. Amen.
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text:
I had the following dream last night, which was unusually long and I somehow managed to recall in vivid detail:
It started off with a recurring nightmare with my mother and I in that scene from the original Jurassic Park where a rainstorm knocks out the power to the electric fence that keeps the T. Rex fenced in. We are in the Jeep like those two kids when the dinosaur comes out and tries to attack us.
My nightmare is, however, different than the movie in three ways:
- I am armed with a sword for some reason
- I try to fight the dinosaur
- I kill the dinosaur by stabbing it in the brain through the eye, but then it falls on me and kills me
Usually I wake up at this point, but last night was different. Last night the dream continued past my crushing, as my soul exited my body…and went straight to Hell.
In Hell, I found out that my brother is Satan. Seriously. My soul was taken to the throne room of Hell and none other than my older brother came out from behind a curtain and sat down on the throne. My brother did not look like the devil. He had neither horns, nor pitchfork, nor hooves, nor was he even wearing red. He was, in fact, wearing the same brown Gucci suit he wore to my cousin Ramon's wedding. Oddly enough, I don't recall being surprised by any of this in the dream.
Figure 2: The awful truth about my brother
I don't remember what my Satanic brother said to me; all I know is that my punishment involved me being reincarnated as 6th grade teacher at my old elementary school. Here are the highlights from my stint as an educator:
1.) Somehow, the kids already know that I'm Native American. When I walk through the doors of the school, they have built a bonfire in the lobby and are dancing around it like Kevin Costner in 'Dances with Wolves.' The principal is participating.
2.) I introduce myself as 'Mr. Johnson' for some reason (this is not my real last name), but the kids refuse to address me by any name other than 'Chief Runny Colon'.
3.) I have two teaching assistants. I have to go upstairs for a meeting with the vice principal, and I leave my students in the charge of the TAs for ten minutes. When I return to the classroom, my teaching assistants are holding a poker tournament with the students, and they are using real money. Most of the female students are being used as cocktail waitresses and are serving booze. EVERYONE is drunk. It's at this point that I realize my TAs are Michael and Dwight from 'The Office'.
4.) For whatever reason, I'm supposed to teach Calculus to 6th graders. The poker tourney inexplicably vanishes and the kids are all in their seats. I'm in the middle of explaining derivatives when some kid behind me yells "YO TEACH! MATH IS FOR NIGGERS!" The kid is Vietnamese. He is also wearing a Rayden hat. The black students jump out of their seats and beat the living shit out of him. I do nothing to stop it. I am subsequently fired.
Figure 3: Did I mention this asshole was the principal?
I woke up at 4:30am laughing my ass off.
You may be wondering why I would hate dreams if this one made me wake up laughing. I'll tell you why. Because there's something in my subconscious that's telling me:
- I'm going to Hell even if I die fighting a 7 metric-ton prehistoric apex predator to save my mother's life
- 11 year old girls can be cocktail waitresses (I suppose this explains the whole 'Hell' thing)
- I associate Asians with Rayden
I've had the regular dreams, sex dreams, and superhero dreams that anyone could consider normal and aren't too difficult to explain. I cannot, however, explain the dream where I'm in a Kay Bee Toy store beating ninjas to death with a fire extinguisher. I cannot explain the dream where my father and are are Achilles and Hector dueling like Brad Pitt and Eric Bana in 'Troy'. I cannot explain the dream where I walk into Willy Wonka's chocolate factory, shoot Willy in the head, then turn around only to be shot in my own head by none other than Katie Couric.
Just take a moment to imagine some of the sick shit you're encountered in your dreams. Now, try to come to the understanding that it's all coming from within your own mind, and that your dreams are only as fucked up as you are. Disturbing isn't it?


text:
Acquiring a business in South Florida takes a certain type of individual who has the backbone and resources to be successful. Using a Florida Business Broker with a knowledge of all the businesses for sale will enhance your chances of selecting the right opportunity.
The South Florida for Me Team of the United Realty Group has created a questionnaire to help guide you through some of the nuances and personality assessment that is required for ensuring your success in purchasing a business in Florida.
Please send an email to firstname.lastname@example.com to request your copy.


text:
The seventh seeds went down 4-6, 1-6 on Saturday. Granollers and Lopez meet Lukasz Kubot and Janko Tipsarevic in the final later in the day. The Polish-Serbian pair got the better of fourth seeds Robert Lindstedt and Horia Tecau 6-2,6-3 in the other semi-final.
Sania wins
Meanwhile, Sania Mirza beat her doubles partner Anastasia Rodionova 6-0, 2-6, 6-2 in Brussels Open Qualification


text:
Question: You are the accountant for a medium size manufacturer Your company
You are the accountant for a medium-size manufacturer. Your company has some existing debt that requires the company to maintain a current ratio of 1.50 or higher. If the ratio drops below that value, the lender can increase the interest rate from 6% to 9%. Recently, the company's current ratio has been hovering around 1.50, and the president believes that when some long-term debt maturing in the following year is reported as current, the ratio will fall below 1.50. The president asks you to keep the long-term debt as a long-term liability instead of reclassifying it as a current liability. "After all, "he says, "it is still reported as a liability."
Is there an ethical issue with the president's request? How should you respond?
View Solution:
Is there an ethical issue with the president's request? How should you respond?
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Answer to relevant QuestionsJohnson Galleries issued $500,000 of 10-year bonds on January 1, 2012. The bonds pay 8% interest semiannually on July 1 and January 1. The market rate of interest on the date of issuance was 8%. Required a. Prepare all ...Where and how are cash dividends reported? What is the difference in the liability exposure of the owner of a corporation compared to the owner in a sole proprietorship or a partnership? A company enters into the following independent transactions: 1. Issues common stock for cash 2. Declares and pays a cash dividend 3. Declares and distributes a stock dividend 4. Purchases treasury stock for cash 5. Declares ...On December 15, Taylor Corporation declared a cash dividend of $0.77 per share to be paid on January 15 to stockholders of record on December 31. Taylor has 154 million shares of common stock outstanding. Required Identify ...
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text:
(CBS) Sweden's "Summer of Love" opened Friday with the first of a series of events to mark the June 19 wedding of Crown Princess Victoria and personal trainer Daniel Westling.
The two will be married in Stockholm's Cathedral in an extravagant $2.3 million affair that will include a parade and military flyover, a barge trip across Stockholm Harbor and a wedding banquet for more than 950 guests.
Pictures: Wedding Preparations
Pictures: The Princess Bride
Pictures: Royal Engagement
The country, which is picking up half the tab for the nuptials of its heir, has billed this as its "Summer of Love" with a sign designating Stockholm's airport as the "Official Love Airport 2010." Royalty from all over Europe and Asia and journalists from around the world are arriving there daily in anticipation of the Saturday wedding.
Some 2,300 journalists are expected to cover the event which will be broadcast live to more than 500 million people.
Festivities began Friday with a Palace lunch hosted by the bride's father, King Carl Gustaf, and a Swedish Government dinner at Eric Ericson Hall in Stockholm.


text:
Mini Orb Necklace, Black Shell, Gold or Silver
$ 96.00
A delicate mini version of our Orb Pendant has iridescent Black Pearl Shell set into a handmade arc pendant. The pendant hangs on a beaded ball cable chain.
Choose from 14K Gold Filled or Sterling Silver
Stone is 4mm round
Pendant is .75" across
Choose from Choker length (adjustable 13"-16") or 18" long chain. If you prefer another length, please specify in the notes section at checkout.
Also available in Rainbow Moonstone in our shop.
Gold Filled has 100 times more gold than gold plated jewelry. Gold filled wire is created by taking a sheet of 14 karat gold and bonding it through extreme heat and pressure to a core of semi-precious metal (brass). This is a very sophisticated process and only a few mills in the world do it. You should not mistake this process for gold plating as there is a very big difference.


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Introducing Skype for Business
One integrated solution, reducing cost and complexity
Skype for Business provides one integrated solution for all online meetings. It allows instant messaging, audio, video and web conferencing with the capability to reach thousands from virtually any device and browser. By upgrading to one solution you are reducing the cost of supporting multiple services.
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Contact anyone in your company, or to anyone on Skype with your chosen device and web browser. Organise meetings with up to 250 people – they simply need a phone or internet connection. Simply click your calendar, Skype for Business client or meeting reminder to join any meeting.
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- Connect from Skype for Business desktop app or from web
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Efficacy, pharmacokinetics, and safety of adalimumab in pediatric patients with juvenile idiopathic arthritis in Japan
- First Online:
- Received:
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The objective of this study was to evaluate the efficacy, pharmacokinetics, and safety of adalimumab in patients with polyarticular juvenile idiopathic arthritis (JIA) in Japan. Patients aged 4 to 17 years were enrolled in a single-arm, open-label, multicentre study of adalimumab. Patients weighing <30 kg received 20 mg every other week (eow), and those ≥30 kg received 40 mg eow. Concomitant methotrexate (MTX) was allowed (≤10 mg/m2 per week). The primary efficacy outcome was the percent of patients with American College of Rheumatology Pediatric 30 response (ACR Pedi 30) at week 16. JIA core variables, serum adalimumab concentrations, and anti-adalimumab antibodies (AAAs) were analysed. Patients were monitored for adverse events (AEs). Twenty-five patients (20 with concomitant MTX at baseline and 5 without) were enrolled: 24 patients completed 16 weeks of therapy and 22 patients completed 60 weeks. At week 16, 90 % of patients with MTX and 100 % without MTX achieved ACR Pedi 30; response rates were maintained through week 60 in 94 and 80 % of patients, respectively. Each JIA core variable improved over time. Six patients became AAA positive (two each at weeks 8, 16, and 60), some of which were transient. All six AAA-positive patients achieved ACR Pedi 30 at week 16, and four maintained that response at week 60. Six patients (all with MTX) experienced nine serious AEs (JIA, pyrexia, arthralgia, pneumonia, hepatitis B infection, pharyngitis, dehydration, pharyngeal pain, and pneumonia). In pediatric patients with polyarticular JIA in Japan, adalimumab was safe and effective for reducing disease activity for up to 60 weeks.
KeywordsAdalimumab Juvenile idiopathic arthritis Methotrexate Pharmacokinetics
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children <16 years of age [1] and often causes significant pain, functional impairment, and diminished health-related quality of life [2, 3, 4, 5]. The incidence of JIA in Japan is estimated to be 10 to 15 per 100,000 children [6]. The overall incidence in developed countries is estimated to range from 16 to 150 per 100,000 children [1]. Of the JIA subtypes, the incidence of polyarticular JIA, which affects five or more joints, has been reported to be relatively high among children in Japan, whereas pauciarticular JIA, which affects four or less joints, is more common in Europe and the USA [6].
The Pediatric Standing Committee of the Japan College of Rheumatology and the Pediatric Rheumatology Association of Japan collaborated to produce guidelines for the diagnosis and treatment of JIA in Japan, with an emphasis on the involvement of pediatric rheumatologists, early intervention, and individualised therapy [6]. For articular JIA, nonsteroidal anti-inflammatory drugs (NSAIDs) are the first-line therapy of choice, followed by disease-modifying antirheumatic drugs (DMARDs) such as methotrexate (MTX) and oral corticosteroids [6]. Patients with JIA often have persistent disease. Consequently, the use of these agents may be limited by long-term toxicity, including potential effects on growth, partial/inadequate responses, and inability to maintain disease remission [7, 8, 9]. Short-term toxicities and drug intolerance are also an issue in this population. Some patients with JIA may benefit from treatment with biologic agents. Further guidance on this topic was recently published by the American College of Rheumatology (ACR) and is under development elsewhere [10, 11]. Availability of biologic therapies, including the anti-tumour necrosis factor (anti-TNF) agents adalimumab, etanercept, and infliximab, the T-cell inhibitor abatacept, and the humanised anti-human interleukin 6 receptor monoclonal antibody tocilizumab, represents a major advancement in the treatment of rheumatic diseases. Of these agents, etanercept, tocilizumab, and adalimumab are approved for JIA in Japan [11, 12, 13].
Adalimumab is a fully human monoclonal antibody specific to human TNF-alpha that is approved in the USA (February 2008) and Europe (September 2008) for the treatment of polyarticular JIA and was recently approved for JIA in Japan [13, 14, 15]. TNF, involved in normal inflammatory and immune responses, is also elevated in the synovial fluid of JIA patients. Adalimumab binds specifically to TNF-alpha and blocks its interaction with cell surface TNF receptors. The relationship between the pharmacodynamic action of adalimumab and the mechanism(s) by which adalimumab exerts its clinical effects is unknown but has been hypothesized to involve significant inhibition of the pathologic inflammatory process. Adalimumab has been shown to be safe and effective in patients with JIA when dosed every other week (eow) for up to 3 years in Western populations [16]. Further, these patients maintained clinical responses and improvements in disease activity for up to 6 years, with no deaths or malignancies reported [17]. The primary objective of this study was to evaluate the efficacy, pharmacokinetics, and safety of adalimumab therapy in pediatric patients with polyarticular JIA in Japan.
Materials and methods
Main inclusion criteria
Pediatric patients aged 4 to 17 years with a diagnosis of polyarticular JIA by ACR criteria at screening, and active disease defined as five or more swollen joints (not due to deformity) and three or more joints with limitation of passive motion due to pain and/or pain by pressure (tenderness), were eligible. Patients could have had systemic, polyarticular, or pauciarticular JIA at disease onset but were required to be free of any systemic JIA manifestations for at least 12 weeks before screening. All patients were to have had inadequate clinical response (or intolerance) to NSAIDs or MTX (8–10 mg per 1 m2 of body surface area per week for 12 weeks or more), or other conventional therapies for JIA such as corticosteroids. Negative urine pregnancy tests at screening and baseline were required for all postpubertal females; use of adequate contraception during the study and for 150 days after last injection was required for all sexually active patients.
Main exclusion criteria
Patients with a history of or comorbid inflammatory joint disease other than JIA, including psoriatic arthritis, arthritis related to enthesopathy, and systematic lupus erythematosus, were excluded. Patients classified as functional class IV by ACR criteria, prior treatment with alkylating agents or biologic therapies for JIA, joint surgery within 8 weeks prior to screening, or articular corticosteroids or sodium hyaluronate within 28 days prior to baseline were also excluded. Other exclusion criteria included the following: significant cardiac disease; abnormal laboratory values; positive serology for anti-human immunodeficiency virus antibody, hepatitis B surface antigen, or hepatitis C antibody; history of a central nervous system (CNS) neoplasm; active CNS infection, demyelinating disease, degenerative neurological disease, or any progressive CNS disease; ongoing chronic or active infection or any major episode of infection requiring hospitalisation or treatment with intravenous antibiotics within 28 days or oral antibiotics within 14 days prior to screening; history of Listeria infection; tuberculosis confirmed by chest X-ray or chest computed tomography at screening or confirmed history of tuberculosis; history of cancer, lymphoma, leukemia, or lymphoproliferative disease other than a successfully treated nonmetastatic cutaneous squamous cell or basal cell carcinoma and/or localised carcinoma in situ of the cervix; and vaccination with a live vaccine within 12 weeks of study drug administration through 70 days of the last dose.
Approved/prohibited medications
MTX was either to be discontinued at least 14 days prior to baseline or, for patients receiving a stable dose (≤10 mg/m2 per week) for ≥12 weeks prior to baseline, could be continued at the stable dose until week 16. After week 16, dose reduction or discontinuation of MTX was permitted based on investigator's judgement. If MTX was reduced or interrupted, it could subsequently be increased or restarted as long as the dose was ≤10 mg/m2 per week.
DMARDs other than MTX were to be discontinued at least 28 days before baseline. NSAIDs or low-dose corticosteroids (≤0.2 mg/kg of prednisone per day, up to a maximum of 10 mg/day, including subcutaneous or intramuscular injection) were permitted at stable doses. Pain medications were not to be taken within 12 h prior to the study visit joint evaluation. Intraarticular injection of corticosteroids or sodium hyaluronate was prohibited until week 16, after which time, one intraarticular injection of corticosteroid or sodium hyaluronate was permitted; however, the joint was considered nonevaluable for 12 weeks after injection. Use of immunosuppressants or leukocytapheresis, alkylating agents such as cyclophosphamide, and analgesic opium alkaloid/synthetic narcotics was prohibited.
Study design and ethics
This single-arm, open-label, multicentre study evaluating the efficacy, pharmacokinetics, and safety of fixed dose adalimumab in pediatric patients with polyarticular JIA was conducted at 14 sites in Japan from May 2008 to August 2010 (NCT00690573). After a 2- to 4-week screening period, patients received subcutaneous adalimumab injections eow. Based on pharmacokinetic simulations performed using body surface area-dependent dosing data from a Western (USA and Europe) clinical JIA study (NCT00048542) [16], a fixed dose dosing regimen was established in which two different doses of adalimumab were administered based on body weight. Patients weighing <30 kg received adalimumab 20 mg eow and patients weighing ≥30 kg received adalimumab 40 mg eow. Adalimumab dosage was re-evaluated based on actual body weight at week 16 and every 12 weeks after week 24 through week 60.
The study was conducted in accordance with the Declaration of Helsinki. In accordance with harmonised good clinical practices, institutional review boards approved the study protocol and the informed consent form. The patient or parent or legal guardian of the patient reviewed and voluntarily signed the informed consent form prior to involvement in any study-related procedures.
Clinical assessments
Clinical measures were assessed at weeks 2, 4, 8, 16, and 24 and every 12 weeks after week 24. The following JIA core criteria were used to calculate ACR Pedi scores: Physician's Global Assessment of disease activity (PhGA), Patient's Global Assessment of well-being (PaGA), active joint count in 73 joints (AJC73), limitation of motion in 69 joints (LOM69), Childhood Health Assessment Questionnaire (CHAQ) to assess physical function, and C-reactive protein (CRP) concentration. ACR Pediatric 30 (ACR Pedi 30) response was defined as ≥30 % improvement in at least three of six JIA core criteria and ≥30 % worsening in not more than one of six JIA core criteria. ACR Pedi 50/70/90 responses were defined similarly according to the respective level of response for at least three of the six JIA core criteria and ≥30 % worsening in not more than one of six JIA core criteria.
Pharmacokinetics and immunogenicity
Blood samples for analysis of serum adalimumab concentrations and anti-adalimumab antibodies (AAAs) were collected at baseline and weeks 2, 4, 8, 16, 24, 36, 48, and 60. A validated enzyme-linked immunoadsorbent assay method based on a double-antigen technique was used to measure adalimumab and AAA concentrations. The lower limit of quantitation (LLOQ) for adalimumab was 3.13 ng/mL in diluted (1:10) serum or 31.3 ng/mL in undiluted serum. The LLOQ for AAAs was 1.0 ng/mL in diluted serum or 10 ng/mL in undiluted serum. Samples were considered AAA-positive if the measured AAA concentration was >20 ng/mL in undiluted serum, and the sample was collected within 30 days after an adalimumab dose. Serum samples with adalimumab concentrations >2 μg/mL were not analysed for AAAs.
The investigator monitored each patient for clinical and laboratory evidence of adverse events (AEs) on a routine basis throughout the study. AEs were also assessed at a follow-up visit 28 days after study completion and 70 days after the last dose of study drug (by site visit or telephone). Duration of exposure was calculated as the number of days between the first dose of study drug and the last dose plus 14 days.
Statistical analysis
As per the prespecified analysis plan, efficacy analyses were conducted on the full analysis set, which was defined as all patients who received at least one dose of study drug. The primary efficacy endpoint, ACR Pedi 30 response rate at week 16, was analysed with non-responder imputation (NRI), whereby patients with missing data at week 16 or who failed to meet ACR Pedi 30 response at week 16 were considered non-responders. Secondary endpoints, including longitudinal data for ACR Pedi 30/50/70/90 response rates and the JIA core variables from week 16 through week 60, were analysed using observed cases (i.e., only patients who were in the study at the time point being evaluated were included). Serum adalimumab and AAA concentrations were summarised descriptively. The numbers and percentages of patients who experienced AEs with an onset on or after the first adalimumab injection up to 70 days (five half-lives) after the last injection were summarised for the safety analysis set, which was identical to the full analysis set.
Patient disposition and duration of treatment
A total of 25 children with JIA were treated with adalimumab, of which 20 were receiving concomitant MTX at baseline. Twenty-four patients completed 24 weeks of therapy, including the primary endpoint assessment at week 16, and 22 patients completed up to 60 weeks. The three patients who discontinued the study, all due to lack of efficacy, were in the concomitant MTX group. The average duration of adalimumab treatment through week 60 was 396 days (390 days for patients receiving concomitant MTX at baseline and 421 days for patients without MTX).
Baseline demographics and clinical characteristics
Demographics and clinical characteristics at baseline
With MTX
Without MTX
All adalimumab
Mean (SD), years
13.2 (3.22)
12.6 (4.39)
13.0 (3.38)
4–12 years, n (%)
9 (45)
3 (60)
12 (48)
13–17 years, n (%)
11 (55)
2 (40)
13 (52)
Female, n (%)
15 (75)
5 (100)
20 (80)
Body weight
Mean (SD), kg
40.5 (11.28)
35.3 (16.64)
39.5 (12.31)
≥30 kg, n (%)
14 (70)
3 (60)
17 (68)
Duration of JIA, mean (SD), years
4.8 (3.97)
4.2 (2.75)
4.7 (3.72)
RF positive, n (%)
14 (70)
3 (60)
17 (68)
Anti-CCP antibody, mean (SD), U/mL
105.5 (135.67)
8.5 (15.50)
86.1 (127.19)
LOM69, mean (SD)
8.6 (5.65)
5.8 (2.05)
8.0 (5.22)
AJC73, mean (SD)
12.0 (6.10)
13.6 (9.32)
12.3 (6.66)
CRP concentration
Abnormal (>0.3 mg/dL), n (%)
11 (55)
3 (60)
14 (56)
Mean (SD), mg/dL
1.0 (1.32)
3.6 (3.86)
1.5 (2.22)
CHAQ (0–3), mean (SD)
0.8 (0.79)
0.7 (1.11)
0.8 (0.84)
PhGA (0–100 mm), mean (SD)
56.5 (18.49)
58.6 (25.83)
56.9 (19.56)
PaGA (0–100 mm), mean (SD)
44.6 (24.84)
48.6 (34.20)
45.4 (26.19)
Baseline PhGA, PaGA, and CHAQ scores were similar between groups. Baseline anti-cyclic citrullinated protein (anti-CCP) antibody concentrations were considerably greater in patients who were receiving MTX compared with those not receiving MTX. All patients had received DMARDs previously. At baseline, all patients were receiving concomitant NSAIDs, and most patients were also receiving concomitant systemic corticosteroids (70 % in the MTX group and 80 % in the non-MTX group).
Primary endpoint: ACR Pedi 30 response
ACR Pedi 50/70/90 responses
ACR Pedi 50/70 response rates at week 16 of adalimumab therapy were generally consistent with those at week 60, with approximately 90 and 75 % of patients achieving these levels of response. Overall, ACR Pedi 90 response rates increased from ≤20 % at week 16 to 50 % at week 60.
JIA core variables over time
JIA core variables at weeks 16 and 60 of adalimumab therapy (as observed)
Adalimumab with MTX
Adalimumab without MTX
Mean baseline value
Mean visit value
Mean % change
Mean baseline value
Mean visit value
Mean % change
Week 16
PhGA (mm)
PaGA (mm)
CRP (mg/dL)
Week 60
PhGA (mm)
PaGA (mm)
CRP (mg/dL)
Pharmacokinetics and immunogenicity
At week 24 of adalimumab therapy, 16 % (4 of 25) patients had at least one AAA-positive serum sample (3 of 20 with MTX [15 %] and 1 of 5 without MTX [20 %]). At week 60, 15 % (3 of 20) of patients receiving adalimumab plus MTX and 60 % (3 of 5) of patients receiving adalimumab without MTX had detectable AAAs (6 of 25 patients [24 %] overall). Two patients first had detectable AAAs at week 8, two at week 16, and two at week 60. Of these six patients, three patients were receiving the 20-mg dosage (one with MTX and two without MTX) and three were receiving the 40 mg dosage (two with MTX and one without MTX).
Trough concentrations of adalimumab <2 g/mL were transient for three of the four patients in whom AAAs were detected prior to week 60. For two of these four patients (one with MTX and one without MTX), the lack of measurable serum adalimumab at a given study visit was followed by detectable adalimumab concentrations that increased at later time points through week 60. Another patient (with MTX) had AAAs detected at week 8 but had measurable adalimumab concentrations at weeks 36 and 48 following dosage increase to 40 mg eow at week 16; the patient's adalimumab concentration was again undetectable at week 60. The remaining patient (with MTX) had undetectable adalimumab concentrations from week 8 to week 60. All six patients with AAA at any time point achieved ACR Pedi 30 response at week 16 and completed the study; four of the six patients exhibited ACR Pedi 30 response at week 60.
Patients with treatment-emergent adverse events
Adverse Event
Adalimumab with MTX
Adalimumab without MTX
All adalimumab
n (%)
n (%)
n (%)
Any AE
20 (100)
5 (100)
25 (100)
Any severe AE
Any AE leading to discontinuation of study drug
1 (5)
1 (4)
Any serious AE
6 (30)
6 (24)
Any infectious AE
16 (80)
5 (100)
21 (84)
Any serious infectious AE
3 (15)
3 (12)
Injection-site reaction
6 (30)
6 (24)
Hepatic-related AE
2 (10)
1 (20)
3 (12)
AEs of special interest
Infections occurred in 80 % of patients receiving MTX and 100 % of patients not receiving MTX, of which three in the MTX group were serious (acute pharyngitis, pneumonia, and hepatitis B infection). Six patients had an injection-site reaction (erythema, swelling, warmth, all in the MTX group) and three had a hepatic event (two in the MTX group, hepatic function abnormal and blood alkaline phosphatase increased; one in the non-MTX group, hepatic function abnormal). No deaths, malignancies, opportunistic infections, congestive heart failure, demyelinating disease, allergic reactions, lupus-like syndrome, or blood dyscrasias were reported in any patient through week 60 of the study.
Polyarticular JIA with RF positivity, which represents approximately 5 % of patients with JIA, tends to be more aggressive than RF-negative polyarticular JIA and is associated with early joint destruction and disability [18, 19]. In addition, RF-positive JIA patients have been found to be less likely to achieve a state of disease inactivity and spend more time in an active disease state compared with RF-negative patients [20]. In the present study, 68 % of patients were RF positive, thus representing a population of patients with potentially severe and difficult-to-treat JIA who are candidates for intensive therapy. Results of this study demonstrate the efficacy of adalimumab in reducing disease activity and maintaining response through 60 weeks of therapy in pediatric patients with polyarticular JIA in Japan. Because the majority of patients in the study were receiving concomitant MTX, firm conclusions regarding the efficacy of adalimumab monotherapy vs. combination therapy are limited; however, adalimumab-treated patients receiving combination therapy with MTX in the Western JIA study had numerically higher ACR Pedi 30, 50, 70, and 90 responses compared with those not receiving MTX [16].
AAAs may develop in some patients during adalimumab therapy. In pediatric patients with JIA in Japan, an AAA-positive result was not associated with study discontinuation or lack of efficacy; all six patients with AAAs completed the study, and four achieved at least ACR Pedi 30 at week 60. AAA positive rates in pediatric patients on concomitant MTX were numerically different, with a higher rate in Japanese vs. Western patients, 15 % (3/20) vs. 5.9 % (5/85), respectively [16]. JIA rates appear consistent with rates observed in Japanese and Western adult RA populations; however, limited pediatric data preclude any correlation with adult RA. In this study, the overall sample size, particularly of the non-MTX group, was too small to make any meaningful comparison of AAA rates to the Western JIA study population.
The similarity of the inclusion criteria between the present study conducted in Japan and the Western JIA study [16] allows for comparison of the results. Disease duration (approximately 4 years) and baseline JIA core criteria generally were similar between patients in both studies; however, a greater percentage of patients in Japan were RF positive at baseline and had received prior DMARD therapy. Notably, ACR Pedi 30 rates at week 16 for patients receiving adalimumab plus MTX were comparable between both studies, with >90 % of patients in each study achieving this efficacy endpoint.
In adult RA, the overall safety profile of adalimumab in Japanese studies is consistent with that observed in Western studies [21, 22, 23]. Similarly, the safety profile of adalimumab in patients with polyarticular JIA in Japan was as expected, based on the safety profile observed in the Western JIA study [16], and no new AEs of interest were observed. Although infections were the most common AE of interest in the present study, no opportunistic infections or tuberculosis were reported through 60 weeks of adalimumab therapy. One event of hepatitis B infection was reported in the present study, and hepatitis B evaluation is recommended for patients receiving biologic therapy.
In addition to adalimumab, two other biologic agents (etanercept and tocilizumab) are approved for the treatment of JIA in Japan. Although head-to-head trials have not been conducted, clinical efficacy as measured by ACR Pedi 30 response rates appears to be relatively similar among these drugs. In a study of DMARD-refractory polyarticular JIA in Japan, etanercept treatment resulted in an ACR Pedi 30 response rate of 91 % at week 12 of the primary study and 94 % at week 96 of the open-label extension [12]. For the anti-interleukin-6 receptor antibody tocilizumab, approved for DMARD-refractory polyarticular JIA and systemic JIA [11], the ACR Pedi 30 response rate was 95 % at week 12 and 100 % at week 48 [24].
Limitations of this study include the open-label study design and small sample size, especially for patients not receiving MTX. In addition, the effect of adalimumab on radiographic progression could not be assessed because X-ray data were not collected. Although the absence of valid and reliable radiographic scoring systems in children with JIA is the primary reason radiographic outcomes have not been included in pivotal JIA trials, measures such as the adapted Sharp-van der Heijde score have been validated and are recommended for use in future pediatric JIA studies [25, 26].
The efficacy, safety, and tolerability of adalimumab were demonstrated and maintained through 60 weeks of therapy in patients with JIA in Japan. The results of the present study were similar to those from a JIA study conducted in the USA and Europe [16]. AAA-positive rates were numerically greater in JIA patients in Japan; however, the development of these antibodies was not associated with study discontinuation or with lack of efficacy. In conclusion, fixed-dose adalimumab (20 or 40 mg eow) was effective in reducing disease activity in pediatric patients with polyarticular JIA in Japan.
Cathryn M. Carter, MS, of Arbor Communications, Inc., funded by Abbott, and Kathleen V. Kastenholz, PharmD, MS, of Abbott, drafted and revised the manuscript. Abbott Laboratories and Eisai Co., Ltd. funded this study (NCT00690573).
Conflict of interest
TI has received research grants from Abbott/Eisai and Novartis, consulting fees from Abbott/Eisai, and speaker's fees from Abbott/Eisai, Chugai, and Mitsubishi Pharma; ST has received research grants, consulting fees, and/or speaker's fees from Eisai, Chugai, Takeda, Bristol-Myers KK, Teijin, Pfizer, Mylan, Mitsubishi Tanebe, Asahi Kasei, and Astellas; HU has received indirect research grants from Abbott and Eisai and speaker's fees from Pfizer and Chugai; KY has received research grants from Eisai/Abbott; YI has received research grants, consulting fees, and/or speaker's fees from Abbott, Eisai, and Chugai; TK has received research grants from Abbott, Eisai, and Chugai; NI has received research grants and speaker's fees from Eisai/Abbott; TM has received research grants from Eisai/Abbott; IO has received research grants from Abbott and Eisai; MMiyoshi has received research grants from Abbott and Eisai; YO has received research grants from Abbott; YK has received indirect research grants from Eisai and Chugai; NK has received research grants from Abbott, Eisai, and Chugai; MMori has received research grants from Abbott, Eisai, Pfizer, and MSD, consulting fees from Pfizer and MSD, and speaker's fees from Abbott, Pfizer, Chugai, Dainippon Sumitomo, and Astellas; SS was an employee of Abbott at the time of manuscript preparation and submission and may hold Abbott stock; he is currently an employee of GlaxoSmithKline and may hold GSK stock or options; SK has received research grants, consulting fees, and/or speaker's fees from Abbott, Astellas, Bristol-Myers Squibb, Chugai, Daiichi-Sankyo, Eisai, Hisamitsu, Janssen, Mitsubishi-Tanabe, Pfizer, Santen, and Takeda; SY has received research grants from Abbott/Eisai and Novartis, consulting fees from Abbott/Eisai and Chugai, and speaker's fees from Chugai, Novartis, and GSK; NM, HK, and GP are employees of Abbott and may hold Abbott stock or options.
Open Access
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
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Just out of curiosity I checked the first quarter of 2007 to the first quarter of this year as far as VIX activity goes. There are some pretty interesting similarities here. The range is less than 10 points, there were no closes over 20 in the first quarter of each year and VIX got to pretty low levels that were not seen in other years.
So looking forward for VIX, 2007 and 2013 started out in similar fashion. Before all was said and done for the year that was 2007 VIX reached the low 30s. Although things have been pretty quiet in VIX so far in 2013, that does not mean things are going to stay that way.
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Facundo Cabral
July 9, 2011 by staff
Facundo Cabral, Men armed with rifles shot and killed one of the popular singers in Latin America's most famous, Facundo Cabral, on Saturday Argentine singer and novelist was on his way to Guatemala's main airport when gunmen attacked his car and hit him with at least eight bullets, said City Fire Department spokesman Jose Rodriguez. Cabral said concert promoter Henry Farina was also injured. The reason was unclear.
Campbell rose to fame in the early 1970′s, belongs to a generation of political protest singers mixed with literary lyrics and created strong bonds with an audience struggling through a time of revolution and repression in Latin America.
Guatemala's President Alvaro Colom said he had called his Argentine counterpart, Cristina Fernandez, to tell of the killing.
"It seemed to hit hard and he asked me to keep her informed of how research is developing," he told Radio Argentina 10. Colom said authorities were interviewing survivors and witnesses andanlyzing images of the video monitors in the area.
"Goodbye, friend," wrote Foreign Minister of Argentina, Hector Timerman, in a message expressing his "deep sadness" over the killing.
Some evidence suggests that the murder was not a simple robbery. Campbell was traveling in a truck tried to flee the attackers by driving a fire station. He was accompanied by a second vehicle has bodyguards; according to television station Notisiete Guatemala.
Police spokesman Donald Gonzalez said agents apparently found one of the vehicles used in the attack, abandoned on the road to El Salvador. He said he was peppered with bullet holes and spent cartridges were found inside.
Cabral, who walked with a cane and had vision problems in recent years, lost his wife and daughter 1 year old in a plane crash in 1978.
"I enjoy life much more because I was hard to enjoy it," he told The Associated Press in an interview in 2008.
"From cradle to grave is a school, so if we call problems are lessons, we see life differently," he said.
His most famous song, "I'm not here nor there" – "I'm not from here and there – there was about 700 times in 27 languages.
A proud wanderer from his impoverished childhood doing odd jobs on the streets of Argentina, Cabral said he would die during a concert tour. "The song is very high," he said. "It's like recreation."
Cabral gave a concert last Thursday in the city of Quetzaltenango, 120 miles away (200 miles) west of Guatemala City.
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Are you a contractor?
While you have been busy working away as an independent contractor the legal profession has been defining your status. Even though you may have a legitimate business entity with an ABN, submit BAS statements, take out insurances etc. etc. you might still be an employee in the eyes of the law. As bizarre as this sounds the fact remains that there is still ambiguity over the definition of an independent contractor. This ambiguity can be seen across the different definitions of a contractor and employee by Federal government agencies where the criteria differ. The ATO, for example, thinks that it is quite simple and define a contractor based on the "degree of control" exercised by the client. If the "employer" can direct "where, when and how" you do your work then you are an employee. For the tens of thousands of professional contractors this is almost certainly the case that they are employees and not contractors according to this definition. More...
Guy Forsyth
The problems of defining an independent contractor
Are you a contractor?


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The rumor mill is again buzzing about the latest Apple (NASDAQ:AAPL) product waiting to be unveiled in their September 12th announcement. The iPhone 5 is basically a given, but rumors are churning about seeing a new iPad (again). This time however, some are expecting to the see the iPad's little brother, dubbed the 'iPad Mini.' If these rumors blossom into facts, what can we come to expect?
First and foremost, it has been made extremely clear that there is a market for a smaller tablet. While Steve Jobs was not a huge supporter of the smaller, 7.85" screen, instead favoring the 9.6" screen, does not mean he wasn't open to the idea. The iPad, though by far the clear favorite in the tablet market, does have some turn offs.
The first, in my opinion would be the lofty price tag. Though fun, easy and dynamic, many will not or cannot shell out $500 for the new device. Even $400 for the iPad 2 can be viewed as expensive to those who can spend only $200 for an Amazon Kindle Fire (NASDAQ:AMZN). The second, is the size. Though acceptable to many, some really do prefer the smaller screen. We all utilize tablets differently, but the fact remains that there is still a market for smaller, cheaper tablets.
Six-month chart of Apple .
An excellent survey was conducted and released on July 19th of this year that revealed the complete usage of the iPad. There is a lot of data in the survey, which is displayed in a very quick and visual manner, allowing readers to quickly go from one statistic to the next, enhanced with graphs. The following statistics popped out the most to me:
- The 'New iPad' was most popular amongst new users despite just being released.
- 47% of iPad-owning households have two or more, up from just 30.1% in 2011.
- 46.6% use their iPad between 2-5 hours per day.
- 46.7% now use the iPad as their primary computer, up from 29.1% in 2010.
These, along with the other statistics provided in the survey, show that not only do people love their iPads, but they are beginning to replace everything they do with it. From using it is as their primary computer source to reading books and watching movies, Apple's device is only increasing in popularity.
Probably the most startling fact for a competitor like Amazon, which is clenching onto the selling points of smaller and cheaper, may soon feel the wrath from Apple: In the study it was revealed that 71% of iPad owners read books on the device. Not that surprising. What is alarming, however, is iBooks, Apple's online bookstore that functions a lot like iTunes does for music. In 2010 the Kindle app received 50% of the viewers reading their books on the iPad, while iBooks only sported 42.4%. Now in 2012, that figure has reversed with only 36.5% of readers using the Kindle app and 51.3% using iBooks.
Also worth taking note, in an article depicting the iPhone retention rate, the iPad follows rather closely. Of the survey results, an astonishing 84.1% "have almost zero interest in rival tablets." This is essentially saying that when someone purchases an iPad, it is almost a guarantee that they will not even consider another tablet should they purchase another one. This a huge vote of confidence for Apple going forward.
One thing sticks out at the end of the survey, only 30% would be interested in a smaller tablet. It is noted to take this information with a grain of salt, since consumers have not seen or used a smaller version of the iPad, but still, this is discouraging. However, Apple's aim would not be to nudge their own product out of the way. It would be to take on the smaller-tablet market.
The smaller-tablet market, consisting of names such as the Google (NASDAQ:GOOG) Nexus 7 and the Amazon Kindle Fire, appeal to a different crowd. For one, they are a lot cheaper, only $250 for a Nexus 7 and $200 for a Kindle Fire. As mentioned above, the iPad 2 runs for $400. A smaller version of the iPad will ultimately allow it to be priced much cheaper than that, probably closer to the price of the Nexus 7. This will appeal to those struggling from a lackluster economy, college students, or those not willing to spend big bucks on the latest and greatest tech gadget. But it has proven that the smaller tablet does sell. If it came down to an Nexus 7 for $250 or an iPad Mini for the same price, which do you think consumers would flock to?
Once Apple has consumers in their hand, it has been proven and noted they do not want to leave. They have found a way to keep consumers craving them, instead of the other way around. A smaller tablet won't likely outperform its bigger brother, the New iPad, but it will cripple the efforts of Google, Amazon and anyone else in the mini tablet market. Just one final thought: Do you hear anyone raving about how great their Samsung Galaxy or Nexus 7 is? I didn't think so.
Disclosure: I have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.


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Manager online games (flash)
I would like to create a section of games online in my blog and sort by category (action, adventure, FPS, RPG…) and each section list the games (title, description and image/thumb) and when click on a game, open the page with the game in the layout of the site.
My question: is there any plugin to manage games, allowing me to create the categories and a simple register: title, description, image/thumb and a field for me to insert the swf code that provides the original site.
And then appear in the listing.
As this excellent download manager that allows to fill out the form to create a new record, but instead of download, I need to run the page code swf to display the game online:
Thank you.
- The topic 'Manager online games (flash)' is closed to new replies.


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Yay!!! So excited to share I was featured over on Hostess with the Mostess for my boys Surf Shack/Underwater Adventure Party. Check it out here. Tweet
Children's Parties
Dual Birthday Party: Surf Shack and Underwater Adventure
A coral reef underwater adventure and surf shack birthday party for your viewing pleasure today. I am so excited to share this party with you! It was definitely an act of love since it was about 4 weeks after having my third baby. We did a lot of the work beforehand, but we were also working up to the last minute! My two oldest boys birthdays are two days apart. This year we decided to do a joint birthday party because I was having our youngest son a month before. I wanted to have two distinct parties in one, so […]
Amy Atlas Featured My Skippyjon Jones Birthday Party!!!
Amy Atlas featured my Skippyjon Jones Birthday Party! Oh man you guys. I am SO excited to share this with you. It's been really hard to keep it a secret, but I now I can finally tell you! I submitted the boys Skippyjon Jones birthday party to the queen of dessert tables Amy Atlas, and they choose to feature my party! Whoo hoo!!! I would apologize for the overuse of exclamation points, but I'm that excited! Anyway, you can go check out the feature here. I'll have more on the party up a little later today. YAY!!! Tweet
Skippyjon Jones Birthday Party
I am so excited to share todays Skippyjon Jones Birthday Party with you! We missed having a 3rd birthday for Asa (since my preggo belly was about to explode at any moment) so I started planning his 4th almost right away. After I got the pictures (from the lovely Courtney Miller), I knew I wanted to submit the party to Amy Atlas for a feature. (But first I had to get the guts to send it in!) So I finally did and now that she has featured it, I can post the details! A few years ago, a good friend […]
Aahhh!!! I was featured at Spaceships and Laser beams!!!
Ummm….so if you couldn't tell from my title, I'm a little bit excited! I submitted a party I did to one very awesome site called, "Spaceships and Laser beams". They specialize in creating super awesome and creative boys parties. Well…they featured my party! It went up today and you can see it here. So excited!!! Tweet
Top Gun Birthday Party
I'm not super proud of how late I am in posting this…but I still think it was a fun party! Last *ahem* February, I asked some of my friends if anyone was interested in me helping them throw a party for their little one. At the time I was wanting to build up my portfolio so I could start a party planning business, but that has since fallen to the way-side (fear not! I still plan on doing parties, and my new business venture is in that realm…muhahah…I just don't want to HAVE TO do it). Well, one of my […]


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"Devotion" tells the inspirational story of the U.S. Navy s most famous aviator duo, Lieutenant Tom Hudner and Ensign Jesse Brown, and the Marines they fought to defend. Read more...
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"Devotion" tells the inspirational story of the U.S. Navy s most famous aviator duo, Lieutenant Tom Hudner and Ensign Jesse Brown, and the Marines they fought to defend. A white New Englander from the country-club scene, Tom passed up Harvard to fly fighters for his country. An African American sharecropper s son from Mississippi, Jesse became the navy s first black carrier pilot, defending a nation that wouldn t even serve him in a bar.
While much of America remained divided by segregation, Jesse and Tom joined forces as wingmen in Fighter Squadron 32. Adam Makos takes us into the cockpit as these bold young aviators cut their teeth at the world s most dangerous job landing on the deck of an aircraft carrier a line of work that Jesse s young wife, Daisy, struggles to accept.
Deployed to the Mediterranean, Tom and Jesse meet the Fleet Marines, boys like PFC Red Parkinson, a farm kid from the Catskills. In between war games in the sun, the young men revel on the Riviera, partying with millionaires and even befriending the Hollywood starlet Elizabeth Taylor. Then comes the war no one expected, in faraway Korea.
"Devotion"takes us soaring overhead with Tom and Jesse, and into the foxholes with Red and the Marines as they battle a North Korean invasion. As the fury of the fighting escalates and the Marines are cornered at the Chosin Reservoir, Tom and Jesse fly, guns blazing, to try and save them. When one of the duo is shot down behind enemy lines and pinned in his burning plane, the other faces an unthinkable choice: watch his friend die or attempt history s most audacious one-man rescue mission.
A tug-at-the-heartstrings tale of bravery and selflessness, "Devotion" asks: How far would you go to save a friend?
Praise for "Devotion
Riveting . . . a meticulously researched and moving account. "USA Today"
An inspiring tale . . . portrayed by Makos in sharp, fact-filled prose and with strong reporting. "Los Angeles Times"
A] must-read. "New York Post"
Stirring. "Parade"
A masterful storyteller . . . Makos brings] "Devotion" to life with amazing vividness. . . . It] reads like a dream. The perfectly paced story cruises along in the fast lane when you re finished, you ll want to start all over again. Associated Press
A delight to read . . . "Devotion" is a story you will not forget. "The Washington Times"
My great respect for Tom Hudner knows no bounds. He is a true hero; and in reading this book, you will understand why I feel that way. President George H. W. Bush
This is aerial drama at its best fast, powerful, and moving. Erik Larson, "New York Times" bestselling author of "Dead Wake"
Though it concerns a famously cold battle in the Korean War, make no mistake: "Devotion" will warm your heart. Hampton Sides, "New York Times" bestselling author of "Ghost Soldiers" and "In the Kingdom of Ice"
At last, the Korean War has its epic, a story that will stay with you long after you close this book. Eric Blehm, "New York Times" bestselling author of "Fearless" and "Legend""
- Publisher: Ballantine Books
- Publish Date: October 2015
- Page Count: 464
- Dimensions: 9.47 x 6.39 x 1.54 inches
- Shipping Weight: 1.68 pounds
Related Categories
Books > History > Military - Korean War
Books > History > Military - Aviation
Books > History > Military - United States
Publishers Weekly® Reviews
- Reviewed in: Publishers Weekly, page .
- Review Date: 2015-08-03
- Reviewer: Staff
Journalist Makos follows 2012's A Higher Call with another true story of heroic actions by wartime pilots, told in a flamboyant and slightly overwrought style. This time the conflict is the Korean War and Makos's tale centers on the first African-American U.S. Navy carrier pilot, Jesse Brown, who died in action even though fellow pilot Tom Hudner, an upper-class son of a New England grocery store magnate, led selfless actions to try to save his life. "There has been no finer act of unselfish heroism in military history," Hudner's commanding officer later said of his courageous attempt to save Brown. The story is told mainly through the voices of the men who took part in the action; Makos and his staff conducted many interviews to use as sources. The overabundant use of reconstructed dialogue—some of which barely rings true—gives the book the feel of an adventure novel. The entire package seems to be an attempt to tell a screenplay-ready, Greatest Generation tale similar to Laura Hillenbrand's Unbroken. Makos tells a good story, but it's not at Hillenbrand's level. Agent: David Vigliano, AGI-Vigliano Literary. (Nov.)


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text: Mrs. Pacheco's Classroom PageThank you for visiting my Kindergarten webpage. The links to the left will help you find your way around here. You can click on any link to help you find out more about me, my class, my contact info, and much more.At the bottom of this page are links to my Remind App, please sign up to receive text messages, and my Class Dojo App to follow your student.


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Drooling Remediation Program
The TalkTools' step-by-step approach to controlling drooling is not a behavioral approach; it addresses the cause of the problem from an Oral Placement perspective, and it's FUN too. This program can be implemented by parents as well as therapists.
Program Includes:
1 Drooling Program Manual
1 Bubble Kit
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1 Straw Kit
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1 Bite Tube Set
1 Vibrator & Toothette (Vibrator requires 2 AAA Batteries - not included.)
3 Tongue Depressors (flavored)
Adult Supervision Required To Implement This Program.
Click here to purchase the manual without the kit.


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The Livermore Airport Citizens Group has raised an alarm about a consultant's report on the building of a new FBO and hangars at Livermore Airport near the San Francisco Bay Area. The group opposes the development of the new FBO on the grounds that it will lead to the airport's becoming a "high growth jetport with increased traffic and noise." The consultant's study concluded that demand at Livermore will grow and that "noise will likely increase to some extent without the FBO–potentially more with the FBO. However, there is no analysis to identify the extent of noise impacts in the future." Million Air Monterey, a division of Del Monte Aviation, won the request for proposal to build the new FBO at Livermore.
New Livermore FBO meets resistance from local residents
- February 8, 2008, 9:47 AM


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We help you find a Mablethorpe recorder teacher. Recorder lessons are a great method to start a stimulating new hobby, acquire a new skill and attain confidence in recorder. Please use our service to find Mablethorpe recorder teachers and determine which best matches your needs so you can enjoy your recorder tuition in Mablethorpe immediately!
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My professor in class today made a statement that fashion has always been dictated by the African American community, and everyone else just follow along.
Is this true? How do you feel about this?
Most Helpful Guy
Not true.
It probably was in the 90's and maybe even early 2000's, but today? No.11|01|0
Thanks for the MHO
Most Helpful Girl
It most certainly feels that way to us. Whenever something new emerges like fashion, slang, a form of music, etc black people have been doing that. For example, "Boxer braids" are trending right now and Kylie Jenner has been credited for for them, but in reality cornrows have existed for centuries and have been worn by Black people since when we were still in our native countries in Africa.22|00|0


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Doctor Hackard was a Federation scientist who lived in the 23rd century.
Hackard was a specialist in dilithium crystals and developed a method of realigning the crystals to increase engine performance on Federation starships. In 2268, Hackard boarded the USS Enterprise and performed his procedure on the Enterprise's crystals. Unfortunately, once the engines were reengaged there was a massive explosion in engineering in which Hackard was killed. (TOS comic: "Cura Te Ipsum")


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de Giulio kitchen design, inc.
de Giulio kitchen design, inc.
1121 Central Ave
Wilmette, IL 60091
(847) 256-8833
Visit Website
M-F 9:00 am -5:30 pm; Sat 9:30 am – 3:30 pm
Design Professionals
Mick De Giulio
Greg Webb
About Mick De Giulio
Since founding de Giulio kitchen design in 1984, Mick De Giulio has been creating kitchens for distinctive residences throughout the United States and abroad. In 2003, he was named a Kitchen and Bath Design Leader by Interior Design magazine and in 2005 was recognized by Kitchen and Bath Business magazine as one of the 50 most influential people in the kitchen and bath industry over the last 50 years. He has designed several product lines for high-end German kitchen manufacturer SieMatic Corporation, has designed a collection of sinks for Kallista (a Kohler company), and recently began designing for leading quartz surface manufacturer, Caesarstone. He is the author of two books, the latest of which is scheduled for a Fall 2015 release by Pointed Leaf Press.
Q&A with Mick De Giulio
Where do you find design inspiration?
Mostly, it's in listening to clients…seeing their vision and trying to take it to the next level for them.
How do you approach the design process?
I think of every project as an opportunity to do something new.
How does your aesthetic standout amongst designers/architects?
There's so much great work being done, and every designer has unique characteristics that define their design.
What is the great asset you provide your client?
Identifying and trying to solve challenges that might not occur to them.
What is your biggest challenge as a designer/architect?
Preconceived limitations - by the client or me.
What does the Sub-Zero and Wolf Kitchen Design Contest mean to you?
I've always felt it represents the best of the best.
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More creativity.
Where do you see kitchen design going in the next 5 years?
I think it will continue to evolve, with designs becoming more unique and individualized.


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Fettuccine With Mascarpone and Parmigiano-Reggiano
READY IN: 30mins
Recipe by ratherbeswimmin
Pasta with a silky sauce
Top Review by breezee1984
mmmmmmmm is all i can say ive never had such a rich sauce, it was perfect
See Discussion:1 Review
Ingredients Nutrition
- 4 large eggs
- 6 tablespoons mascarpone
- 1 teaspoon sea salt
- fresh ground black pepper (about 24 turns of the pepper mill)
- 1 lb dried fettuccine
- 1 cup freshly grated parmigiano-reggiano cheese, plus extra to pass at the table
Directions See How It's Made
- Bring a big pot of water to a boil.
- Meanwhile, whisk the eggs, mascarpone, salt, and pepper in a heatproof mixing bowl that is large enough to sit on top of your pasta pot; set aside.
- Add a generous amount of salt to the boiling water; add in fettuccine; cook at a full boil, stirring frequently, until al dente.
- While the pasta is cooking, rest the mixing bowl above the boiling water to warm the mixture, stirring frequently, to prevent the eggs from curdling.
- When the fettuccine is al dente, drain it and toss the pasta into the mascarpone mixture.
- Fold in the Parmigiano-Reggiano; toss, and serve immediately.
- Pass extra cheese and pepper at the table.


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Mark ("Moose") Charlap (December 19, 1928 – July 8, 1974) was a Jewish-American Broadway composer. Born Morris Isaac Charlip in Philadelphia, he was best known for "Peter Pan" (1954), for which Carolyn Leigh wrote the lyrics. The idea to do the show came from Jerome Robbins, who planned to have a few songs by Charlap and Leigh. However, the show evolved into a full blown musical, with additional songs by Jule Styne and Betty Comden and Adolph Green. It starred Mary Martin as Peter Pan and Cyril Ritchard as Captain Hook.
Charlap was married to singer Sandy Stewart, whose biggest hit was My Coloring Book in 1962. They had one son--Bill Charlap, a well-known jazz pianist. Charlap had a daughter Anne Charlap and son Tom Charlap, a bass player, from a previous marriage.
Work on Broadway
- Peter Pan (1954, revivals in 1979, 1990, 1991, 1998, 1999) - musical - composer
- Whoop-Up (1958) - musical - composer
- The Conquering Hero (1961) - musical - composer
- Kelly (1965) - musical - composer
- Jerome Robbins' Broadway (1989) - revue - featured songwriter for "Peter Pan"
External links
- Mark "Moose" Charlap at the Internet Broadway Database
|This page uses content from the English Wikipedia. The original article was at Mark Charlap. The list of authors can be seen in the page history.


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Elm, Salome, AZ 85348
Status: Active
Property Description
Priced to sell, there are 2 parcels large enough for a well and septic system. the taxes are for both properties and they will give the new buyer a new parcel number after the close of escrow where both parcels will become one. Be the first to buy into this area for a really good price. Salome is in a rural community with a grade school and high school. Airparks and golfing, RV's beautiful mountains.
Listing Information for Elm Salome, AZ 85348
No Sewer
School Information for Elm Salome, AZ 85348
Room Information for Elm Salome, AZ 85348
Interior Features for Elm Salome, AZ 85348
Exterior / Lot Features for Elm Salome, AZ 85348
Community Features for Elm Salome, AZ 85348
Driving Directions to Elm Salome, AZ 85348
SW to Salome, L on to Salome Rd, R onto Harquhala, L into Castle lakes, follow road to L on Hickory, R on Wells Dr. to the property on Elm Way lots 786 & 787.
Financial Considerations for Elm Salome, AZ 85348
Listing Price History for MLS#: 4849568
Salome AZ Real Estate and Salome AZ Homes for Sale
Salome is located in the state of Arizona. The zip code of 85348 has a population of 1,467. The median age of people living in Salome, AZ 85348, is 60.1 years.
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text: 000 FXUS63 KMQT 152227 AFDMQT Area Forecast Discussion National Weather Service Marquette MI 627 PM EDT Tue Aug 15 2017 .SHORT TERM...(This evening through Wednesday) Issued at 350 PM EDT TUE AUG 15 2017 No significant hazards expected in the short term. Will continue to see clouds diminish from W to E this evening as high pressure works in. For tonight, uncertainty exists in fog/stratus formation that is possible over the N-central and E, but the extent will be largely dependent on the extent of high level clouds that will be moving in from the W. Overnight lows will also be dependent on cloud cover. Some rain showers may move into western Upper MI on Wed, mainly in the afternoon, ahead of the SFC low that will be over central MN by the end of the day. .LONG TERM...(Wednesday night through Tuesday) Issued at 312 PM EDT TUE AUG 15 2017 The arrival of the strengthening low pressure system that has been advertised for days still looks to move across Upper Michigan late Wednesday night through Friday. The models have remains consistent with the track of this low across portions of Upper Michigan and Lake Superior during the day on Thursday. As the warm front pushes north and moisture transport ramps up, as the ridge of higher theta- e noses into the region, expect a fairly widespread area of rain to move across much of the area. With PWATs approaching 1.5-2.0 inches and warm cloud layer depths approaching 11,000-13,000 feet, rain may fall heavy at times. Right now the timing of this rainfall across the west looks to be early Thursday morning through early afternoon hours. The highest amounts are expected to reach the 1.5-2.0 inch range primarily over the western half of Upper Michigan, where not only the leading edge of the better moisture will take aim, but also where wrap around precipitation within the deformation zone will linger into the evening hours on Thursday. Through the morning and afternoon hours, as the low pressure system tracks across the area and the warm front lifts north the area of fairly widespread rain showers will lift into central and eastern portion of the area. Through the afternoon hours, models try to bring in a dry slot across central portions of Upper Michigan. This will allow for a break in the rainfall in some locations; however, as the cold front pushes through later in the afternoon and evening hours, depending on how much instability can get into south central portions of Upper Michigan, there may be a round of afternoon/evening thunderstorms near the triple point and south along the cold front. While mid- level lapse rates do not look terribly impressive, resulting in skinny CAPE profiles, models are forecasting upwards of 1500-2000 J/kg with around 30-40 knots of bulk shear. Therefore, it isn`t out of the question that if we can get additional development, a few storms could be on the stronger side across the south central on Thursday afternoon/evening. This remains conditional as it will all depend on how cloud cover evolves during the afternoon hours and how far north the better moisture can get. Lingering wrap around showers are possible across the central and east Thursday night into Friday morning as the area of low pressure moves over eastern Lake Superior and eventually tracks eastward into Canada. Low-level wind fields are fairly consistent with northwest winds behind the exiting low across much of the area, albeit not as conducive in some locations to upslope flow as northerly flow would be, still expect low clouds and perhaps some drizzle across northern and eastern portions of the area on Friday. Due to the lingering cloud cover and cold air advection behind the system, temperatures will be about 10 degrees below normal. The first part of the weekend looks like we could see a few showers and perhaps a few rumbles of thunder as another shortwave trough swings through the region. As this shortwave digs into the eastern Great Lakes region, high pressure will take over on Sunday and allow for temperatures to climb a few degrees above normal with drier weather. A few locations may even see temperatures climb into the lower 80s by the end of the weekend. Early next week upper-level flow looks to become more zonal with broad longwave troughing spanning much of central Canada. This will push a trailing cold front eastward across the Upper Great Lakes region and return chances for showers and thunderstorms. Unfortunately, right now it looks like cloud cover may hinder our ability to see the partial solar eclipse on Monday. However, given the transition from a quasi-amplified upper-level pattern to more zonal, there certainly is time for things to change! && .AVIATION...(For the 00Z TAFS through 00Z Wednesday evening) Issued at 626 PM EDT TUE AUG 15 2017 VFR conditions will continue at IWD and CMX through the forecast period. Low stratus and fog will move into KSAW tonight with conditions going to IFR and will then burn off to MVFR conditions Wed morning. && .MARINE...(For the 4 PM Lake Superior forecast issuance) Issued at 350 PM EDT TUE AUG 15 2017 High pres building over the Upper Lakes will result in winds mostly under 15kt across Lake Superior into tonight. Easterly winds will then increase Wed into Thu as low pres moves from the Central Plains to the Upper Great Lakes. Wind gusts on Thu will be as high as 30kt as the low reaches the area. Could be higher if the low pres is deeper. These stronger winds will linger into Fri over eastern Lake Superior as the low departs. Lighter winds, mostly under 15kt, are expected over the weekend with high pres over the region. && .MQT WATCHES/WARNINGS/ADVISORIES... Upper Michigan... None. Lake Superior... None. Lake Michigan... None. && $$ SHORT TERM...Titus LONG TERM...Ritzman AVIATION...07 MARINE...Titus


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Two magnificent ponds overlooking the High Uintas! Driveway,power,well,septic tank and house plans.Right off the scenic
Two majestic ponds, home plans, well, septic and driveway included. Electrical already in place. This lot has it all! 90 min from Salt Lake City and right off Mirror Lake Highway (Utah HWY 150), around 25 minutes from Evanston. BUILD A LEGACY DREAM CABIN only 90 Minutes from Salt Lake City! Enormous amount of dollars already invested on this amazing land. Huge opportunity. Seller moved away and needs an offer. His loss your gain. Start building today! 2200 acres and only 31 lots. No words can describe Monviso. Call me for a visit anytime.
For more information regarding this land, please give us a call at View Phone Number (650) 580-9095 .
Data Provided by Park City Board of REALTORS
Information Deemed Reliable but Not Guaranteed.
This information is being provided for Consumers personal, non-commercial use and may not be used for any purpose other than to identify prospective properties Consumers may be interested in purchasing.More Information for this listing


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Hi beautiful,I was just browsing through & stumbled upon your lovely blog - It looks gorgeous and it has interesting posts that I can relate to. I'm now following you via gfc, keep in touch love xBenish | Feminist Reflectionshttp://femministreflections.blogspot.com/
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The Ides of March (iTunes/SD)
Canadian Code (iTunes/SD).
Redemption Quality is not Guaranteed.
**You are only purchasing THIS PORTION of the code. Redemption for iTunes or any other format is prohibited and will not be guaranteed. All codes are tracked and unpaid for redemptions will be charged to your account and the account will be suspended for future transactions.**
The Ides of March takes place during the frantic last days before a heavily contested Ohio presidential primary, when an up-and-coming campaign press secretary (Ryan Gosling) finds himself involved in a political scandal that threatens to upend his candidate's shot at the presidency. -- (C) Sony Pictures
|R (for pervasive language)
(These emails will not be replied back to)


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This is a very short collection of art by artist Laura Kitching featuring captions for each piece as well.
Being an artist myself, I can easily appreciate the work of art collected in this booklet. The artwork is very unique and all give a very mysterious and naturey feeling being blotted black and white and featuring mountains/mushrooms/ect. My favorite piece out of this booklet is number Three: The repositioning of geological structures.
I am very happy to have another collection of art by an awesome artist. It's a great way to look upon and gather inspiration from.
To find more of Laura's work, visit elkandowl.com
4 out of 5 stars


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Take a voyage of discovery
"Use all the talents you have at your disposal to make your situation fit you - not the other way round. Find a niche that allows you to be comfortable, happy and fulfilled," Yeung says.
The author holds a PhD in exercise and sports psychology, with an emphasis on motivation and peak performance, and is an in-demand television personality on CNN, and the BBC's
The book covers seven aspects of personality, including resilience, conscientiousness, sensitivity and knowledge questing.
Readers are invited to fill in questionnaires to find out in which dimension they are in. The author provides you with an understanding of the nature of your personality, the situations that suit you and those that don't, and suggests how you can make the most of yourself.
He then gives tips to create a personal action plan. First, decide which aspects of your personality you want to work on and get a second opinion from someone who knows you well and who has your best interests at heart. It is also important to set goals you can score.
The book is written in a positive and encouraging tone so that you won't feel down even when you discover or confirm some of your weaknesses. The author's approach seems to underscore his belief that we are all different and that there is nothing about ourselves to be ashamed of. Instead, we should tailor a personal action plan that maximises our strengths.
For example, people with low inquisitiveness should recognise how down-to-earth they are. "You thrive when you spend most of your time on practical matters rather than abstract ideas and fanciful possibilities. So learn that you will succeed when you find that sweet spot," Yeung writes.
While playing to our strengths does not mean we can excuse our flaws, which in the case of people with low inquisitiveness means they should train themselves to think out of the box, the author says these individuals should focus on being a "doer" rather than spend the bulk of their time learning how to work with concepts and ideas. The book also has easy-to-follow suggestions on how to eliminate bad habits.
For people with low resilience, for instance, the author suggests they take timeout when they are worrying and focus on performing an easy rote task.
He then gives examples of ways to override disruptive emotions. "Write a detail about a neutral or pleasant topic such as a recent holiday. Replay a favourite song in your
head or pick up a dictionary and write out sentences incorporating words you've never come across before."
Ultimately, this book is about finding who you are and being comfortable with your unique self. It is only then that you will enjoy what you do at work as in life.
Four insights
- People with low affiliation: grow your network, join sports teams, charity groups, clubs and community groups.
- People with high affiliation: you are a people person, but it is important to listen to what people say. Then decide when to speak – if at all.
- People with low drive: write down what you want your life to look like in 10 years, listing all the steps to make it happen. Then pick an easy action and do it today.
- People with high drive: you may push yourself to heroic lengths, but others may not like to be pushed. Learn how to coach and explain. Unleash the potential in others through praise.


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Bumper and light bar install??
Information and questions on GL1200 Goldwings (1984-1987)
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Bumper and light bar install??
Can someone help with directions to install the Drag specialties bumper and upper light bar. I bought it off someone who removed it from a 86 Aspencade. I have no directions on install or wiring instructions! My ride is a 85 Interstate. Any help would be greatly appreciated.
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We are dealing in Fresh Banana that is organically cultivated by using qualitative fertilizers by keeping in mind the food and safety standards. Experts accomplish procurement and storage of Fresh Banana, thus quality is assured. Buyers can contact us for availing Fresh Banana in bulk quantities. We are known Exporter and Supplier of Fresh Banana in India.
Tilak Exports
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We offer Fresh Bananas that are grown through organic farming. Our Fresh Bananas are highly nutritious and are demanded for their freshness and taste. We cultivate the Fresh Bananas under controlled conditions. Fresh Bananas are used for making ice-creams, shakes, custard, candies, chips, and so on.
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We offer Fresh Green Banana in India as well as abroad. These Fresh Raw Banana are fresh and without any spots and marks. We offer Fresh Raw Banana that are tasty and contain a rich amount of valuable nutrients such as vitamin B6, vitamin C and potassium. The clients can avail Fresh Raw Banana at affordable price. We pack as per our client's requirement. Features Fresh Affordable price Rich nutrients Hygienic packi
Malaviya Exim
A-113, Surbhi Flat, B/h Shabri School, Vasna Petrol Pump, Gujarat - 390007, India


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Strand, London, WC2R 0ET
Excellent. Easy to Book a show. Good website
Provided good tickets at a discount promptly.
Thirty-five years after the groundbreaking original Broadway production, this UK and West End premiere of the sensational and iconic Tony Award®-winning musical Dreamgirls is now playing at the Savoy Theatre, London. Nominated for 5 Olivier Awards including Best New Musical, Dreamgirls transports you to a revolutionary time in American music history and charts the tumultuous journey of a young female singing trio from Chicago, Illinois called 'The Dreams'. They learn the hard lesson that show business is as tough as it is fabulous. Dreamgirls features the classic songs "And I Am Telling You I'm Not Going", "I Am Changing", "Listen" and "One Night Only".This much-anticipated new production is directed and choreographed by the hugely successful, Tony® and Olivier award-winning Casey Nicholaw (The Book of Mormon, Aladdin, Something Rotten!) and starring Amber Riley (Glee) as Effie White. At London's Savoy Theatre, book your Dreamgirls tickets today! *PLEASE NOTE: The producers cannot guarantee the appearance of any particular artist(s). Amber Riley is currently scheduled to play the role of Effie White for 5 out of 8 performances per week. On 3 out of 8 performances per week, currently scheduled on Monday evenings, Wednesday matinees and Saturday matinees, the role of Effie White will be played by either Marisha Wallace or Karen Mav. This is subject to change and may be affected by contracts, holiday, illness, or events beyond the producers' control. Amber Riley will NOT perform on the following dates:- Tuesday 26 - Wednesday 27 September - Friday 13 - Tuesday 17 October
Cheapest Tickets for Dreamgirls, Savoy Theatre, London West End
Booking Your "Dreamgirls" London West End Tickets:
"Dreamgirls", Savoy Theatre tickets may be purchased by following the Book Tickets links on this page. You will be purchasing your "Dreamgirls" tickets from the Ticket Machine Ltd, trading as LOVEtheatre. We will always provide you with our contact details before you book your "Dreamgirls" tickets.
"Dreamgirls" London West End Ticket Sales and Booking Prices:
Where applicable, "Dreamgirls", Savoy Theatre ticket prices may include a booking fee which will always be shown separately. LOVEtheatre will not charge you any additional amounts for the dispatch/delivery of your "Dreamgirls" tickets. Prices are subject to change without notice.
"Dreamgirls" London West End Booking Confirmation:
Your purchase of "Dreamgirls", Savoy Theatre tickets is conducted securely online using 256-bit encryption assured by DigiCert. On receipt of full payment for your "Dreamgirls" tickets we will issue a confirmation of booking. When booking online this will be in the form of a confirmation page and accompanying confirmation email.
At LOVEtheatre, we are dedicated to providing access to the full range of ticket options; from full price tickets to the cheapest ticket deals for London West End Theatre, Events and Attractions, backed up by outstanding customer service. We source special ticket deals, meal packages, cheap tickets and more to give you great choice, value for money and quality of service. Book tickets for London Theatre direct with LOVEtheatre.
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What are we talking about when we talk about capacity? The answer should be straightforward, given that ideas of "capacity" and "capacity building" frame the way many of us think about – and do – development. But often the response is fuzzy and unclear...
SLRC/ODI Researcher, Richard Mallett
When most people talk about capacity, they actually mean either "stuff" – resources and equipment – or hard skills in some technical discipline. This is the obvious starting point: without proper medical facilities or trained staff, how can a local health clinic do its job? Which is probably why so many capacity building programs try to fill deficits by giving stuff and providing technical training. But often the real problems confronting service providers have nothing to do with what's available in a tangible or technical sense – this might be a symptom, but it's not the root of the problem. So what do we then do in terms of thinking about capacity?
Read the full blog : Beyond Stuff: Capacity as a Relational Concept
Secure Livelihoods Research Consortium,
Overseas Development Institute,
203 Blackfriars Road,
London SE1 8NH
Telephone number: +44 (0)20 7922 0300
Fax: +44 (0)20 7922 0399
Email: firstname.lastname@example.com