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Vitamin D Info
Other Names:
Alfacalcidol: 1-alpha-hydroxycholecalciferol, 1-alpha-hydroxycholécalciférol, 1 alpha (OH)D3.
Calcifediol: 25-HCC, 25-hydroxycholecalciferol, 25-hydroxycholécalciferol , 25-hydroxyvitamin D3, 25-hydroxyvitamine D3, 25-OHCC, 25-OHD3, Calcifédiol.
Calcipotriene : Calcipotriène, Calcipotriol.
Calcitriol: 1,25-DHCC, 1,25-dihydroxycholecalciferol, 1,25-dihydroxycholécalciférol, 1,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamine D3, 1,25-diOHC, 1,25(0H)2D3.
Cholecalciferol: 7-déhydrocholestérol Activé, Activated 7-dehydrocholesterol, Cholécalciférol, Colecalciferol, Colécalciférol, Vitamin D3.
Dihydrotachysterol: DHT, Dihydrotachystérol, dihydrotachysterol 2, dichysterol, Vitamine D3.
Ergocalciferol: Activated Ergosterol, Calciferol, Ergocalciférol, Ergocalciferolum, Ergostérol Activé, Ergostérol Irradié, Irradiated Ergosterol, Viosterol, Viostérol, Vitamin D2, Vitamine D2.
Paricalcitol: 19-nor-1,25-dihydroxyvitamin D2, 19-nor-1,25-dihydroxyvitamine D2, Paracalcin.
Fat-Soluble Vitamin, Vitamina D, Vitamine D, Vitamine Liposoluble.
Vitamin D is a vitamin. It can be found in small amounts in a few foods, including fatty fish such as herring, mackerel, sardines and tuna. To make vitamin D more available, it is added to dairy products, juices, and cereals that are then said to be "fortified with vitamin D." But most vitamin D – 80% to 90% of what the body gets – is obtained through exposure to sunlight. Vitamin D can also be made in the laboratory as medicine.
Vitamin D is used for preventing and treating rickets, a disease that is caused by not having enough vitamin D (vitamin D deficiency). Vitamin D is also used for treating weak bones (osteoporosis), bone pain (osteomalacia), bone loss in people with a condition called hyperparathyroidism, and an inherited disease (osteogenesis imperfecta) in which the bones are especially brittle and easily broken. It is also used for preventing falls andfractures in people at risk for osteoporosis, and preventing low calcium and bone loss (renal osteodystrophy) in people with kidney failure.
Vitamin D is used for conditions of the heart and blood vessels, including high blood pressure and high cholesterol. It is also used for diabetes, obesity, muscle weakness,multiple sclerosis, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD),asthma, bronchitis, premenstrual syndrome (PMS), and tooth and gum disease.
Some people use vitamin D for skin conditions including vitiligo, scleroderma, psoriasis, actinic keratosis, and lupus vulgaris.
It is also used for boosting the immune system, preventing autoimmune diseases, and preventing cancer.
Because vitamin D is involved in regulating the levels of minerals such as phosphorous and calcium, it is used for conditions caused by low levels of phosphorous (familial hypophosphatemia and Fanconi syndrome) and low levels of calcium (hypoparathyroidism and pseudohypoparathyroidism).
Vitamin D in forms known as calcitriol or calcipotriene is applied directly to the skin for a particular type of psoriasis.
If you travel to Canada, you may have noticed that Canada recognizes the importance of vitamin D in the prevention of osteoporosis. It allows this health claim for foods that contain calcium: "A healthy diet with adequate calcium and vitamin D, and regularphysical activity, help to achieve strong bones and may reduce the risk of osteoporosis." But the US version of this osteoporosis health claim does not yet include vitamin D.
How does it work?
Vitamin D is required for the regulation of the minerals calcium and phosphorus found in the body. It also plays an important role in maintaining proper bone structure.
Sun exposure is an easy, reliable way for most people to get vitamin D. Exposure of the hands, face, arms, and legs to sunlight two to three times a week for about one-fourth of the time it would take to develop a mild sunburn will cause the skin to produce enough vitamin D. The necessary exposure time varies with age, skin type, season, time of day, etc.
It's amazing how quickly adequate levels of vitamin D can be restored by sunlight. Just 6 days of casual sunlight exposure without sunscreen can make up for 49 days of no sunlight exposure. Body fat acts like a kind of storage battery for vitamin D. During periods of sunlight, vitamin D is stored in fatty fat and then released when sunlight is gone.
Nevertheless, vitamin D deficiency is more common than you might expect. People who don't get enough sun, especially people living in Canada and the northern half of the US, are especially at risk. Vitamin D deficiency also occurs even in sunny climates, possibly because people are staying indoors more, covering up when outside, or using sunscreens consistently these days to reduce skin cancer risk.
Older people are also at risk for vitamin D deficiency. They are less likely to spend time in the sun, have fewer "receptors" in their skin that convert sunlight to vitamin D, may not get vitamin D in their diet, may have trouble absorbing vitamin D even if they do get it in their diet, and may have more trouble converting dietary vitamin D to a useful form due to aging kidneys. In fact, the risk for vitamin D deficiency in people over 65 years of age is very high. Surprisingly, as many as 40% of older people even in sunny climates such as South Florida don't have enough vitamin D in their systems.
Vitamin D supplements may be necessary for older people, people living in northern latitudes, and for dark-skinned people who need extra time in the sun, but don't get it.
Effective for:
- Treating conditions that cause weak and painful bones (osteomalacia).
- Low levels of phosphate in the blood (familial hypophosphatemia).
- Low levels of phosphate in the blood due to a disease called Fanconi syndrome.
- Psoriasis (with a specialized prescription-only form of vitamin D).
- Low blood calcium levels because of a low parathyroid thyroid hormone levels.
- Helping prevent low calcium and bone loss (renal osteodystrophy) in people with kidney failure.
- Rickets.
- Vitamin D deficiency.
Likely Effective for:
- Treating osteoporosis (weak bones). Taking a specific form of vitamin D called cholecalciferol (vitamin D3) along with calcium seems to help prevent bone loss and bone breaks.
- Preventing falls in older people. Researchers noticed that people who don't have enough vitamin D tend to fall more often than other people. They found that taking a vitamin D supplement reduces the risk of falling by up to 22%. Higher doses of vitamin D are more effective than lower doses. One study found that taking 800 IU of vitamin D reduced the risk of falling, but lower doses didn't.
Also, vitamin D, in combination with calcium, but not calcium alone, may prevent falls by decreasing body sway and blood pressure. This combination prevents more falls in women than men.
- Reducing bone loss in people taking drugs called corticosteroids.
Possibly Effective for:
- Reducing the risk of multiple sclerosis (MS). Studies show taking vitamin D seems to reduce women's risk of getting MS by up to 40%. Taking at least 400 IU per day, the amount typically found in a multivitamin supplement, seems to work the best.
- Preventing cancer. Some research shows that people who take a high-dose vitamin D supplement plus calcium might have a lower chance of developing cancer of any type.
- Weight loss. Women taking calcium plus vitamin D are more likely to lose weight and maintain their weight. But this benefit is mainly in women who didn't get enough calcium before they started taking supplements.
- Flu. Some research in school aged children show that taking a vitamin D supplement during winter might reduce the chance of getting seasonal flu.
- Reducing the risk of rheumatoid arthritis in older women.
- Reducing bone loss in women with a condition called hyperparathyroidism.
- Preventing tooth loss in the elderly.
Possibly Ineffective for:
- Breast cancer. Many studies have looked at whether vitamin D can help prevent breast cancer, but their results have not always agreed. The best evidence to date comes from a large study called the Women's Health Initiative, which found that taking 400 IU of vitamin D and 1000 mg of calcium per day does not seem to lower the chance of getting breast cancer. The possibility remains that high doses of vitamin D might lower breast cancer risk in younger women. But the doses needed would be so high that they might not be safe.
- High blood pressure.
- Improving muscle strength in older adults.
- Preventing bone loss in people with kidney transplants.
Insufficient Evidence for:
- Heart disease. Research suggests that people with low levels of vitamin D in their blood are much more likely to develop heart disease, including heart failure, than people with higher vitamin D levels. However, taking vitamin D does not seem to extend the life of people with heart failure.
- High cholesterol. People with lower vitamin D levels seem to be much more likely to have high cholesterol than people with higher vitamin D levels. Limited research shows that taking calcium plus vitamin D daily, in combination with a low-calorie diet, significantly raises "good (HDL) cholesterol" and lowers "bad (LDL) cholesterol" in overweight women. But taking calcium plus vitamin D alone, does not reduce LDL cholesterol levels.
- Gum disease. Higher blood levels of vitamin D seem to be linked with a reduced risk of gum disease in people 50 years of age or older. But, this doesn't seem to be true for adults younger than 50.
- Diabetes. People with lower vitamin D levels are significantly more likely to have type 2 diabetes compared to people with higher vitamin D levels. But, there is no reliable evidence that taking vitamin D supplements can treat or prevent type 2 diabetes.
- Premenstrual syndrome (PMS). There is some evidence that getting more vitamin D from the diet might help to prevent PMS or reduce symptoms. Taking vitamin D supplements might help reduce symptoms but doesn't seem to help prevent PMS.
- A blood cell disease called myelodysplastic syndrome.
- A muscle disease called proximal myopathy.
- Colorectal cancer.
- Warts.
- Bronchitis.
- Asthma.
- Breathing disorders.
- Metabolic syndrome.
- Muscle pain caused by medications called "statins."
- Vaginal atrophy.
- Other conditions.
Vitamin D is LIKELY SAFE when taken by mouth in recommended amounts. Most people do not commonly experience side effects with vitamin D, unless too much is taken. Some side effects of taking too much vitamin D include weakness, fatigue, sleepiness, headache, loss of appetite, dry mouth, metallic taste, nausea, vomiting, and others.
Taking vitamin D for long periods of time in doses higher than 4000 units per day isPOSSIBLY UNSAFE and may cause excessively high levels of calcium in the blood. However, much higher doses are often needed for the short-term treatment of vitamin D deficiency. This type of treatment should be done under the supervision of a healthcare provider.
Special Precautions & Warnings:Pregnancy and breast-feeding: Vitamin D is LIKELY SAFE during pregnancy and breast-feeding when used in daily amounts below 4000 units. Do not use higher doses. Using higher doses might cause serious harm to the infant.
Kidney disease: Vitamin D may increase calcium levels and increase the risk of "hardening of the arteries" in people with serious kidney disease. This must be balanced with the need to prevent renal osteodystrophy, a bone disease that occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood. Calcium levels should be monitored carefully in people with kidney disease.
High levels of calcium in the blood: Taking vitamin D could make this condition worse.
"Hardening of the arteries" (atherosclerosis): Taking vitamin D could make this condition worse.
Sarcoidosis: Vitamin D may increase calcium levels in people with sarcoidosis. This could lead to kidney stones and other problems. Use vitamin D cautiously.
Histoplasmosis: Vitamin D may increase calcium levels in people with histoplasmosis. This could lead to kidney stones and other problems. Use vitamin D cautiously.
Over-active parathyroid gland (hyperparathyroidism): Vitamin D may increase calcium levels in people with hyperparathyroidism. Use vitamin D cautiously.
Lymphoma: Vitamin D may increase calcium levels in people with lymphoma. This could lead to kidney stones and other problems. Use vitamin D cautiously.
Moderate Interaction Be cautious with this combination
- Aluminum interacts with VITAMIN D
Aluminum is found in most antacids. Vitamin D can increase how much aluminum the body absorbs. This interaction might be a problem for people with kidney disease. Take vitamin D two hours before, or four hours after antacids.
- Calcipotriene (Dovonex) interacts with VITAMIN D
Calcipotriene is a drug that is similar to vitamin D. Taking vitamin D along with calcipotriene (Dovonex) might increase the effects and side effects of calcipotriene (Dovonex). Avoid taking vitamin D supplements if you are taking calcipotriene (Dovonex).
- Digoxin (Lanoxin) interacts with VITAMIN D
Vitamin D helps your body absorb calcium. Calcium can affect the heart. Digoxin (Lanoxin) is used to help your heart beat stronger. Taking vitamin D along with digoxin (Lanoxin) might increase the effects of digoxin (Lanoxin) and lead to an irregular heartbeat. If you are taking digoxin (Lanoxin), talk to your doctor before taking vitamin D supplements.
- Diltiazem (Cardizem, Dilacor, Tiazac) interacts with VITAMIN D
Vitamin D helps your body absorb calcium. Calcium can affect your heart. Diltiazem (Cardizem, Dilacor, Tiazac) can also affect your heart. Taking large amounts of vitamin D along with diltiazem (Cardizem, Dilacor, Tiazac) might decrease the effectiveness of diltiazem.
- Verapamil (Calan, Covera, Isoptin, Verelan) interacts with VITAMIN D
Vitamin D helps your body absorb calcium. Calcium can affect the heart. Verapamil (Calan, Covera, Isoptin, Verelan) can also affect the heart. Do not take large amounts of vitamin D if you are taking verapamil (Calan, Covera, Isoptin, Verelan).
- Water pills (Thiazide diuretics) interacts with VITAMIN D
Vitamin D helps your body absorb calcium. Some "water pills" increase the amount of calcium in the body. Taking large amounts of vitamin D along with some "water pills" might cause to be too much calcium in the body. This could cause serious side effects including kidney problems.
Some of these "water pills" include chlorothiazide (Diuril), hydrochlorothiazide (HydroDIURIL, Esidrix), indapamide (Lozol), metolazone (Zaroxolyn), and chlorthalidone (Hygroton).
Minor Interaction Be watchful with this combination
- Cimetidine (Tagamet) interacts with VITAMIN D
The body changes vitamin D into a form that it can use. Cimetidine might decrease how well the body changes vitamin D. This might decrease how well vitamin D works. But this interaction probably isn't important for most people.
- Heparin interacts with VITAMIN D
Heparin slows blood clotting and can increase the risk of breaking a bone when used for a long period of time. People taking these medications should eat a diet rich in calcium and vitamin D.
- Low molecular weight heparins (LMWHS) interacts with VITAMIN D
Some medications called low molecular weight heparins can increase the risk of breaking a bone when used for a long periods of time. People taking these medications should eat a diet rich in calcium and vitamin D.
These drugs include enoxaparin (Lovenox), dalteparin (Fragmin), and tinzaparin (Innohep).
The following doses have been studied in scientific research:
- For preventing osteoporosis and fractures: 400-1000 IU per day has been used for older adults. Some experts recommended higher doses of 1000-2000 IU daily.
- For preventing falls: 800-1000 IU/day has been used in combination with calcium 1000-1200 mg/day.
- For preventing multiple sclerosis (MS): long-term consumption of at least 400 IU per day, mainly in the form of a multivitamin supplement, has been used.
- For preventing all cancer types: calcium 1400-1500 mg/day plus vitamin D3 (cholecalciferol) 1100 IU/day in postmenopausal women has been used.
- For muscle pain caused by medications called "statins": vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol) 50,000 units once a week or 400 IU daily.
- For preventing the flu: vitamin D (cholecalciferol) 1200 IU daily.
The Institute of Medicine publishes recommended daily allowance (RDA), which is an estimate of the amount of vitamin D that meets the needs of most people in the population. The current RDA was set in 2010. The RDA varies based on age as follows: 1-70 years of age, 600 IU daily; 71 years and older, 800 IU daily; pregnant and lactating women, 600 IU daily. For infants ages 0-12 months, an adequate intake (AI) level of 400 IU is recommended.
Some organizations are recommending higher amounts. In 2008, the American Academy of Pediatrics increased the recommended minimum daily intake of vitamin D to 400 IU daily for all infants and children, including adolescents. Parents should not use vitamin D liquids dosed as 400 IU/drop. Giving one dropperful or mL by mistake can deliver 10,000 IU/day. The US Food and Drug Administration (FDA) will force companies to provide no more than 400 IU per dropperful in the future.
The National Osteoporosis Foundation recommends vitamin D 400 IU to 800 IU daily for adults under age 50, and 800 IU to 1000 IU daily for older adults.
The North American Menopause Society recommends 700 IU to 800 IU daily for women at risk of deficiency due to low sun (e.g., homebound, northern latitude) exposure.
Guidelines from the Osteoporosis Society of Canada recommend vitamin D 400 IU per day for people up to age 50, and 800 IU per day for people over 50. Osteoporosis Canada now recommends 400-1000 IU daily for adults under the age of 50 years and 800-2000 IU daily for adults over the age of 50 years.
The Canadian Cancer Society recommends 1000 IU/day during the fall and winter for adults in Canada. For those with a higher risk of having low vitamin D levels, this dose should be taken year round. This includes people who have dark skin, usually wear clothing that covers most of their skin, and people who are older or who don't go outside often.
Many experts now recommend using vitamin D supplements containing cholecalciferol in order to meet these intake levels. This seems to be more potent than another form of vitamin D called ergocalciferol.


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Another View -- Kelly Ayotte and Jeanne Shaheen: Stop the bickering, start governingSEN. KELLY AYOTTE (R-N.H.) and
October 12. 2013 1:10AM
GRANITE STATERS are rightly frustrated and fed up with the current gridlock in Washington that has resulted in a government shutdown that is hurting families and small businesses. We share that frustration - and we know that our country deserves better from their elected representatives. That's why we're calling on Republicans and Democrats to come to the table now, work out a plan to reopen the government, and develop a long-term deficit reduction plan that will move us beyond this impasse.
Too many in Washington are wasting time and energy finger-pointing and playing the blame game instead of working together to find a way forward. During an informal bipartisan get-together we hosted earlier this week for our women colleagues in the Senate, there was unanimous agreement that members of both parties need to put politics aside and act in the best interests of our country.
Washington could take a lesson from our state's long, proud tradition of bipartisanship and compromise. In the Senate, we don't agree on every issue, but we are committed to working together on behalf of our constituents. And we've been successful as a result.
In just the past year, we've worked together to bolster our small business exporters because we know it will help grow our economy. Together we lead a key Armed Services subcommittee responsible for overseeing our military's readiness, which has allowed us to be strong advocates for the Portsmouth Naval Shipyard and its dedicated workforce. And we were proud to support the Pease Air National Guard Base's 157th Air Refueling Wing's successful effort to become the new home of the KC-46A refueling tanker.
When it comes to our nation's fiscal challenges, we have been part of bipartisan efforts to produce a long-term deficit reduction package that will put our country on a more fiscally sustainable path. That effort would be bolstered - and future crisis situations could be avoided entirely - if Washington did its job and passed a budget and appropriations bills on time. To that end, we support legislation that would force Congress to budget responsibly and rein in excessive spending while also requiring better oversight and stewardship of taxpayer dollars.
The American people sent 535 representatives to Washington to work together to address difficult issues and to move our country forward. They did not send us here to manufacture crises, skirt our responsibilities, and bicker with one another. Regardless of political party, everyone should agree that the stalemate in Washington is unacceptable. And for each day that we let it continue, our country is paying too heavy a price.
We have a divided government, but governing is not a winner-take-all sport. We should seize this opportunity to successfully address the many challenges facing our country - and that means putting an end to partisan bickering and starting to actually listen to one another. It's time for our nation's leaders to stop the partisan gamesmanship and start governing and working across the aisle in good faith. That's what is expected of us as elected representatives of the American people, and they deserve nothing less.
Jeanne Shaheen, D, and Kelly Ayotte, R, represent New Hampshire in the U.S. Senate.

subset: commoncrawl


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A group representing Oregon counties has asked state legislators to prohibit them from regulating genetically modified organisms.
Representatives of the Association of Oregon Counties said the group supports a proposal that would preempt local governments from banning biotech crops or other agriculture practices.
"Counties don't have the expertise or the staff or the money," said Mary Stern, the group's president, during a Sept. 26 legislative hearing.
The proposal is included as part of a broader legislative package aimed at state pension reform and school funding that will be considered at a special session that Gov. John Kitzhaber said he will convene on Sept. 30.
Stern admitted that it's rare for counties to advocate for less local control, but she said it's unrealistic to expect counties to find and hire experts who can oversee biotech regulations.
It has been four months since the USDA announced that unauthorized biotech wheat was found growing in eastern Oregon, but investigators still haven't resolved how the release occurred, she said.
If the USDA has trouble resolving such issues, then county governments would have even greater challenges regulating genetic engineering, Stern said.
"This bill is about government. It's not about Monsanto," she said, referring to a major biotech developer. "Please don't let cities and counties provide this regulation. We can't do it."
Gov. Kitzhaber also testified during the hearing, saying there is "no question" that the biotech preemption bill was outside the framework of the legislative session, but it's necessary to prevent a patchwork of county-by-county regulations.
"This is about whether we should have 36 different GE policies or one state policy," he said, referring to the number of counties in Oregon.
Opponents of the proposal — which passed the Senate as Senate Bill 633 earlier this year but died in a House committee — testified that it should not have been revived.
Ivan Maluski, policy director at Friends of Family Farmers, said the bill shouldn't be included in a package of unrelated pension and tax proposals.
"It takes away local control" without establishing a statewide system of regulating biotech crops, he said.
Maluski said federal and state agencies were not doing their job in regulating biotech crops, as evidenced by unauthorized biotech wheat in eastern Oregon, which is why counties must step up to the plate.
Others who testified offered a variety of viewpoints on genetically modified crops.
Aiden Humphrey, a resident of Lancaster, Ore., said the "biotech fumes" in the countryside around his home were sometimes so strong that his family has to drive around in their car to get fresh air.
He urged legislators not to pass the pre-emption bill.
"It strips away any local control of our food supply," Humphrey said.
Supporters of the bill also testified during the hearing, saying it will prevent onerous new regulations for farmers who produce crops in more than one county.
Brenda Frketich, a Willamette Valley farmer, said county-by-county biotech rules would create a "logistical disaster," as you can't contain pollen within county lines.
"I think we will be faced with impractical laws on what we can grow based solely on fear and emotion," she said.
Rodney Hightower, a farmer near Junction City, Ore., said genetically engineered crops like sugar beets can be grown responsibly without harming organic farmers.
"It's not a pest," he said. "It's not a boogey man."