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A critical aspect of the Human Genome Project's large-scale sequencing program has been the production of very high quality data. This has required the establishment of quality standards for genomic DNA sequence. This document, in three sections, describes: I) the most up-to-date quality standards and definitions for genomic sequence; II) an account of the rationale for, and history of, the establishment of those quality standards; and III) the descriptions and results of sequence quality assessment exercises that have been done to determine the quality of the data produced by the public sequencing community so far.
The goal of the Human Genome Project is to produce a sequence of human DNA that is of sufficiently high accuracy and long-range contiguity to allow a full interpretation of all the information encoded in the human genome, and that will stand the test of time. The HGP sequencing effort has also adopted an intermediate product for human genomic sequence termed "working draft" sequence because, although it cannot be used for all conceivable methods of DNA analysis, draft quality sequence can be very useful in identifying a number of features in DNA, e.g. coding sequences and repeats. In establishing different sequence "products," it was also important to develop quality standards appropriate to each. In addition, some of the quality standards that have been developed are specific for the particular strategy employed in generating the sequence data. As different strategies are implemented to improve large-scale DNA sequencing (for example, for future target genomes), it is likely that additional or different quality standards will need to be developed. Accordingly, the HGP regularly revisits quality standards to ensure that they remain relevant to the overall sequencing program.
"Finished Sequence" is a term used to refer to a region of DNA sequence on which, after a best-faith effort by the sequencing laboratory to resolve all difficult regions and to generate a high quality, completely continuous representation, no further sequencing will be done. The actual definition is provided by the following set of criteria. These standards were derived for the mapped BAC-by-BAC strategy undertaken for human sequencing by the International HGP, but are readily adaptable to finished sequence obtained by other strategies.
Since the standards above refer primarily to the individual finished BAC projects used in a BAC-by-BAC strategy rather than a large assembly, it is also important to have standards that define a finished chromosome. Note that these standards generally apply to the euchromatic portions of the chromosome, as cloning of heterochromatic regions is still technically unreliable. The biology of the target organism should be considered in applying these guidelines. For example, C. elegans is holocentric, which affects the ease of obtaining long-range contiguity.
The current standards for working draft were developed for the mapped BAC-by-BAC sequencing strategy.
Additional information to be included with human draft accessions:
It is anticipated that, after the human, large genome sequences are likely to be determined by a mixed mapped BAC/whole genome shotgun (WGS) strategy. The standards for finished sequence obtained by this strategy are the same as those above for finished sequence determined by the mapped BAC approach. The quality standards for a working draft sequence that has been determined by such a hybrid strategy have not yet been finalized. However, the working draft standards will necessarily have to be modified from those established for the human working draft (among other reasons, it will not be appropriate to assess coverage on a per-BAC clone basis for this strategy, at least until the assembly is undertaken). Nonetheless, the overall coverage standard for working draft sequence obtained by WGS or hybrid methods of 4X in Q20 bases is an appropriate one at this time. Variables that should be considered in setting a draft coverage standard include the state-of-the-art in genome assembly programs, and the biological utility of the information at different levels of coverage, versus cost. Precisely how this standard will be implemented and assessed will need to be resolved in further discussion. In the interim, it may be appropriate to set standards for the quality of elements that lead to the desired product such as read quality, data tracking, and assembly quality.
The quality of genomic sequence produced by the HGP was understood to be important at the beginning of the program. In its 1988 report, the NRC's Committee on Mapping and Sequencing the Human Genome stated "A mechanism of quality control is needed for the groups that are contributing sequencing information". As DNA sequencing began to move into a production mode in the mid-1990's, specific quality standards were defined. At the February 1996 meeting of the National Advisory Council for Human Genome Research, the Council recommended that, in developing means to address the productivity of the pilot project program for large-scale human DNA sequencing, the quality of the DNA sequence data produced was an important criterion. Shortly thereafter, the issues were again discussed at the First International Strategy Meeting on Human Genome Sequencing, where the necessity of developing clear standards and effective means for measuring quality were re-affirmed. It was also suggested that it was critical to identify regions of sequence known to be of relatively lower quality.
To follow up these calls for attention to quality assessment, the then-NCHGR held a workshop on DNA Sequence Validation on April 15, 1996. The major conclusions at this workshop related specifically to finished sequence (the only sequence product being pursued at that time), and were critical in establishing and inculcating quality standards and routine assessment into production sequencing in the public effort. The major conclusions at this workshop were:
Subsequent to that workshop, the NHGRI continued to discuss the formulation of standards based on the recommendations above, along with input from the community. Other discussions, both within and outside of NHGRI, continued to emphasize the importance of establishing quality standards and measurements. At its February 1997 meeting, the National Advisory Council for Human Genome Research agreed that it would be important for the Institute to establish a sequencing standard. The Council agreed that the goal of 99.99% accurate sequence was an appropriate quality standard for human genomic sequence. However, the Council recognized that the means for measuring sequence quality were inadequate to determine whether that standard was being met. The Council instructed NHGRI staff to develop a metric, however interim, for measuring sequence quality.
In March, 1997, the attendees at the Second International Strategy Meeting for Large Scale Sequencing agreed that the goal for sequencing standards should be an accuracy level of 99.99%, and that there were no good metrics that an outside group could use to confirm the quality of sequence. A second criterion was defined at this meeting, that the sequence should have no gaps. Recognizing, however, that this goal was far from being achieved, there was agreement that when a group was unable to fill a gap, information about the size of the gap, the orientation of its flanking regions and the effort made to close it, should be included in the sequence annotation in the public database. The attendees suggested that it might be possible to assess data quality if sequencing groups were to exchange sequence data files and attempt to reassemble the completed sequence from that information. Based on these several discussions, NHGRI adopted its current sequencing standard for grantees engaged in large-scale sequencing of human DNA, and began to conduct regular quality assessment exercises.
Sequence quality issues have also been discussed at two meetings of the Principal Investigators of the NHGRI-sponsored large-scale sequencing grants, which took place in July and December of 1997. These investigators affirmed that contiguity is an important quality parameter for NHGRI to monitor. At the July 1997 meeting, the participants agreed that a contig should be at least 30 kb in size to be reported as finished sequence to NHGRI. They further agreed that this minimum size should increase over time, to a standard of having an average contig length of 500 kb.
Gaps and Ambiguities
- The definitions of gaps and ambiguities have also been refined at these meetings. At the July 1997 PI meeting, the discussion concluded that ambiguities should be considered as gaps. At the December 1997 PI meeting, it became apparent that there should be a distinction between ambiguities and gaps, but this distinction should not lessen the incentive to produce sequence without ambiguities or gaps. It was proposed that gaps should be defined as regions where there were no sequence reads, whereas ambiguities were where such reads had occurred but the base could not be called unambiguously. Ambiguities are to be counted as errors, against the standard of an error rate of no more than 1 in 10,000.
Before the completion of human chromosome 22, discussion at the Sixth International Strategy Meeting for Large Scale Sequencing adopted the working standard above (I.2) for what should be considered an "essentially completed" chromosome.
As the genome was moving towards completion, additional measures were established to assess quality of the underlying chromosome clone maps. At the May, 2001 International Meeting, and as refined in subsequent International Meetings, a tracking system for map gap closure was instituted. This relied on two reports produced by the chromosome coordinators (individuals at the sequencing centers responsible for the chromosome): the Tiling Path Format (TPF) is a spreadsheet denoting each clone in the tiling path in order (regardless of state of completion) and any gaps in that tiling path. The gap report listed and annotated (with regard to size, flanking clones, and closure efforts) all remaining map gaps according to the following definitions:
Type 1: a gap known to be anchored by sequence on either side. For Type 1 gaps there should be a clone(s) in the pipeline that will close it.
Type 2: a gap without identified spanning sequences, but with a spanning clone (or clones) in the map.
Type 3: a gap without a spanning clone of any type (between fingerprint contigs).
Type 4: a gap without a spanning clone of any type and for which all known libraries have been screened. Libraries include all publicly available BAC or PAC libraries. Probes must be screened to at least 30X depth of BAC libraries before a Type 3 gap can be declared to be Type 4.
This reporting system, updated at regular (bi-monthly or monthly) intervals, allowed continuous assessment of many aspects of the quality of the underlying maps as the genome progressed towards closure, including number of remaining gaps, finishing/draft status of individual clones, missing markers from other maps, and assessment of quality of the joins between individual clones.
During 1998, NHGRI and DOE held a number of workshops to discuss goals for an updated Five-year Plan. In the course of these workshops, the value and importance of finished sequence was reconfirmed. However, there was also discussion of the high value of producing a "working draft" sequence which was defined as an intermediate sequence product that would cover the vast majority of the genome, be available to the community in two years or less and would in the end contribute to the goal of producing a finished sequence. This sequence was envisioned to be of lower accuracy and contiguity than finished sequence but it would nevertheless be very useful, especially for finding genes, exons, and other features through sequence searches. In order to evaluate the utility of such a working draft sequence a set of computational analyses was undertaken by several biologists. The results were discussed at a meeting in September, 1998 and indicated that a working draft sequence would be of enormous immediate benefit to those searching for genes and other features in the human genome sequence. The participants suggested that quality standards be set for the working draft but they urged caution to avoid a situation in which meeting over-defined standards will be a significant distraction from finishing.
The participants proposed the following minimum standards for an intermediate product:
>90% of sequence present
>99% accuracy (proposed surrogate: 3X coverage in Phred 20 bases)
In March, 1999 the five sequencing groups with the largest capacities met to discuss undertaking a project to produce a working draft of the sequence by Spring, 2000. These groups had successfully scaled their centers over the previous six months to the point that their combined projected capacities could accomplish this feat. As the group's plan developed, it was discussed with the International community at the May 1999 International Strategy Meeting. This group of sixteen sequencing centers agreed to participate in the production of the working draft. During the summer of that year, the five largest centers met again to discuss a quality standard, which was then presented to and approved by the International group in September 1999.
The quality standard agreed upon and reported in the final report of the September 1999 International meeting was: "The total number of Phred-20 bases in contigs greater than 1 kb must be at least four times the size of the clone insert. This is the bulk expectation of a center's output, but should be reported on a clone by clone basis. It was also suggested that centers should report the fraction of BACs that fall below this standard in their working draft, with the expectation that this fraction will be small. Although there was not a consensus agreement that this should be done, centers who are interested in doing this are encouraged to do so."
One outcome of the discussions summarized in Section II of this document was that, by 1997, NHGRI had decided to conduct quality assessment (QA) of sequence data produced by the centers it funds, to ensure standards are met. Several of these QA exercises have now occurred for both finished and working draft sequence. Each of these assessments was designed in consultation with the principal investigators of either the NHGRI-funded sequencing centers or of the international sequencing centers. In most of these assessment exercises, randomly selected sequencing projects and corresponding trace data from one center were assessed by another (either two other sequencing centers among the international consortium, or an outside group). For human working draft, it was possible to assess the quality of the data computationally, with reference to the publicly deposited information only.
Following the discussion at the Second International Strategy Meeting, NHGRI initiated a short experiment to determine whether reanalysis of raw sequencing data would be useful to reveal weaknesses in finished sequence and to estimate the quality of the data. In this experiment, each of the NHGRI-funded sequencing groups submitted raw sequence data and ancillary information representing two completed clones. These data were analyzed by two other groups, which each used their own methods to reassemble the sequence. The results were reported to NHGRI and distributed to all of the participants. Then, on May 13-14th, 1997, the participants met to discuss the results.
In general, the exercise was considered to have been very useful and successful in finding discrepancies and potential weak areas in the data. Because each group used different assembly tools, it was not surprising that the results from the two checkers were not identical. But it was reassuring that the checkers' data basically agreed on which sequence data were stronger and which were weaker. The participants endorsed an expansion of the exercise to improve the process and assess the quality of the sequence being generated by NHGRI grantees over the following year. The following outline was agreed upon for the expanded exercise:
NHGRI selected four finished clones, at random, totaling 200 kb, from each participating sequencing group (all NHGRI human plus D. melanogaster). Data eligible for being checked was selected from that deposited as 'finished' as of September, 1997.
NHGRI assigned each set of four clones to two checkers chosen from among the participants; groups exchanged data files and bacterial isolates/DNA. Checkers re-assembled files and analyzed the data. If the error rate was better than 1 in 2000, checkers resolved discrepancies by further analysis (resequencing). Most groups also checked assembly by restriction analysis, although this was not in the original instructions.
Each group was given the opportunity to respond to the checker's reports.
Total number of clones available for checking as of 9/97: 420
Total number of clones selected for the exercise: 37 (a total of 1.7 Mb tested)
TABLE 1: Single-base discrepancies--number of clones at error ratea:
- These numbers are based on the higher error rate between the two checker's reports, for each individual clone; these numbers do not take into account the producer's responses.
- For 7 out of the 10 clones in this category, one of the two checkers actually evaluated those clones as having fewer than 1 in 10000 errors.
Total number of single-base discrepancies (conservative aggregate of two checkers): 230/1.7 Mb.
Total excluding the clones worse than 1 in 2000: 120/1.59 Mb
About 2/3rds (133) of the single-base discrepancies were substitutions, 1/3rd (73) were insertions or deletions, based on 206 cases of single-base errors where precise information was provided.
Other errors (not exclusive of single-base errors)
4 misassemblies, some likely to be due to small deletions (~250-1900 bp) in the large-insert clone
1 annotated gap closed (75 bp)
* 1 wrong clone sent (clone tracking error)
Caveats: Variability due to sampling; variability in checking
Most groups are sequencing at or very close to standards: Most groups were achieving 1 in 10000 or better, summed over all clones. Numbers in the table are conservative and do not include the producer's responses, consideration of which will improve the error rates. However, most of the producers responses agree with the checkers' reports.
Good concordance between checkers' reports: For single-base errors, both checkers agreed on the general quality of the project (according to the bins in Table 1) 28 of 37 times, and were very close in all other cases. In 11 of 19 clones where error type and location appear in the report, there is at least a 50% overlap in the precise identified errors. But there were still some puzzling differences between the identified errors in an individual clone, especially when there were a lot of errors or trace data were considered poor by checker. For other types of error (deletions, etc.), both checkers agreed in all but one case.
The exercise revealed useful information about the kinds of error: Clone instabilities (small deletions) were a small but significant problem-small deletions may be hard to detect with routine protocols. (Note that this exercise included cosmids as well as BAC and PAC clones-several of the small deletions were in cosmids.) Single-base errors often occur in regions where sequence data quality is good-more than half could be resolved unambiguously by re-editing the original data without need to re-sequence (36/53 errors; some of this was confirmed by resequencing).
This exercise used the same protocol as the previous exercise: 4-5 projects from each group totaling ~200 kb were tested; each set of clones checked by two checkers; reassemble data; find discrepancies with GenBank entry; resolve by resequencing or re-editing; confirm assembly with restriction analysis. The exercise focused on recently produced data (within the previous year). There were 17 participants including the Berkeley Drosophila genome sequencing center, the DOE sequencing labs, the Sanger Centre, and others within and outside the NHGRI sequencing program.
TABLE 1. What was checked
ESTIMATE of percentage of human clones checked:
Amount of finished human data in GenBank as of Nov 3, 1998: ~210 Mb. At ~110 kb per clone, =~1900 clones.
@ 52 clones checked, ~2.7 % of total human finished projects in GenBank as of October 1998 were checked.
@ 2.6 Mb checked, ~1.2 % of total human finished sequence in GenBank as of October, 1998 was checked.
Projects were checked against the finished GenBank or EMBL versions as of Nov 3, 1998.
TABLE 2. Combined summary of results for all participants
1The numbers after the "plus" sign correspond to clones (cosmids) that were less than 50 kb, but contained no errors.
TABLE 3. Combined summary of results for human data only
Note: These data are an aggregate of the results of human data being produced by NHGRI-funded centers, the DOE, and the Sanger Center. It also includes human data from other producers.
1 The numbers after the "plus" sign correspond to clones (cosmids) that were less than 50 kb, but contained no errors.
Two quality assessments of human working draft sequence have been conducted so far.
Trace files from 10 recent (Fall, 1999) projects from each of the three largest NHGRI-funded centers (those producing the bulk of the working draft sequence) were transferred to an outside laboratory (Dr. Richard Myers and Mr. Jeremy Schmutz, Stanford University) for re-assembly and assessment against the coverage standard established for human working draft sequence. Read data quality and assembly was also assessed (even though no standards for these had been established). In all cases, the submitted data met or exceeded standards.
1 P20 Insert refers to usable Phred 20 bases divided by estimated insert size; P20 Assem is the usable Phred 20 bases divided by assembled bases. These correspond to the two methods for calculating working draft coverage specified in Section 1 of this document.
2 Number of contigs >1kb.
3 This value is an overage of the values for two centers, since an estimation of insert size was not available for one center's data.
Dr. John Bouck (Baylor College of Medicine) computationally assessed a majority (nearly 9,000) of human projects in the public database that were labeled ?HTGS_draft? on May 24, 2000. These accessions contain associated quality data enabling the assessment of coverage in Q20 bases by purely computational means.
Additional computational assessments of the human working draft sequence will be carried out leading up to publication of the results (projected for Fall, 2000). Those responsible for the 26 draft projects with coverage <3 were asked to improve or withdraw them from the HTGS_draft category.
To complement these computational assessments, NHGRI and GenBank monitored HTGS_draft depositions for contaminating sequences (e.g., vector, E. coli) so that these could be removed. It was clear from the these and other informal assessments that it would be useful to monitor contamination in HTGS_draft accessions on a continuing basis. GenBank maintains an updated list, available by FTP, of projects it has identified as being contaminated. Centers are responsible for checking this list and correcting their own contaminated projects. NHGRI and GenBank also monitor depositions to ensure that the standard information accompanies each accession (quality scores, end sequences identified.
Last Updated: March 9, 2012


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The Messy Paint and Play Playtime at Hello Little Artisan
Suitable for Children Age 1-5
Cost: $20 plus Eventbrite administrative fee
Session: Monday, Thursday or Friday 10:45am-11:45am
At Hello Little Artisan we understand the importance of children engaging in sensory and creative play. Each session is set up with stations that will inspire children to use their curiosity and creativity to explore different textures and materials.
Messy Play is an important part of Early Child Development.
The Benefits of Messy Play include:
*Communication and Language Development
*Improved Fine and Gross Motor Skills
*Improved Hand Eye Coordination
*Problem Solving Skills
*Making Choices
*A positive approach to new experiences
*Developing new friends
Each child session will provided the opportunity to make their own choices regarding the art and craft equipment by either painting, mixing, cutting, gluing, constructing, moulding and experiencing a variety of sensory materials.
Each child will begin to make their thoughts visible through their own creative explorations.
Hello Little Artisan is a place where we focus on the process of making and creating, not the final product. This is a place where it's ok to be messy!
What is provided at a Messy Play Session:
* All art, craft and sensory materials
* Smocks for children and aprons for adults
* Out door area for messy play
* Garden Studio for quieter activities
* Toilet and clean up facilities.
* Plenty of space for prams.
* Breast feeding friendly
* Age appropriate activities
* A qualified teacher (Bach. Ed) with a passion for art and craft
What you might like to bring:
* Clothes that can get messy
PLEASE NOTE: Parents/Carers must remain with their child on the premise at all times. Street parking is available. When you arrive please enter through the side gate and you will see the studio.
All enquires to firstname.lastname@example.com or phone 0400320772
More photos and details at www.facebook.com/hellolittleartisan


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The Middle East is awash with positive sentiment around startups, and a regular flow of accelerators, incubators and venture capital funds have been launching in recent months to the audible cheer of entrepreneurs.
Yet, is it actually getting easier to fund a startup in the Middle East? Yes, but there's still a long way to go.
That was the conclusion of a Google Hangout organised by The Wall Street Journal and a panel of experts in the startup field across the Middle East.
The panel of five included Wassim Kabbara, head of retail & local in MENA at Google; Sam Quawasmi, managing director of crowdfunding site Eureeca.com; Ramez Mohamed, chief executive of Cairo accelerator Flat6Labs; Hind Hobeika, founder of wearable tech startup Instabeat; and Chris Schroeder, the author of Startup Rising.
Here are the key takeaways from the discussion:
1. Things are changing. More accelerators, angel investors and venture capital funds from inside and outside the region are interested in buying into the Middle East.
2. Entrepreneurs should have their business plan in order before seeking investment, and get educated quickly on the financials.
3. The type of investment received, and from whom, is crucial to growing a business and building a brand in the Middle East.
4. Unfortunately, banks are not lending very much to small businesses just yet.
5. And more investors are needed across the region, across sectors and at every funding level.


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Mammoth got hit over the weekend, so did Whistler. Looks like the storm is heading further inland to the Rockies and the Wasatch. Is it snowing in your neck of the woods? Let us know. The storm is winding down in California but Mammoth is planning on opening 100% lifts and terrain by this Friday, December 7.
Mammoth Mountain, CA
Base: 50-70 in.
Surface: Fresh Powder,Packed Powder
Storm Total: 4-6 ft
Fresh Snow – 24 hours: 12.1″
Fresh Snow – 48 hours: 14.6″
Fresh Snow – 72 hours: 34.6″
Whistler, BC, Canada
- 22cm—24HR
- 59cm—48HR
- 143cm—7 DAYS
- 174cm—BASE
Get out there and ride.


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Cross Country USCAA National Championships Results
Meet Information
Date of Meet: November 11, 2011
Name of Meet: USCAA National Championships
Host: Paul Smith's College, Paul' Smith's College, NY
Course description: In body of right up.
Course distance: Men – 8K (4.97mi)
Women – 6K (3.73mi)
Conditions: Overcast, 42 with light breeze and 1/2 " snow on ground
Team finish results: Attached. No team score as had 4 men and 2 women running.
|Philip Boody
|17th of 149
|Justin Fereshetian
|33rd of 149
|Dan Dermody
|63rd of 149
|Richard Landry
|144th of 149
|Kati Christoffel
|8th of 111
|Emily Wright
|28th of 111
The U-Maine at Presque Isle cross country teams were well represented at their 17th overall and first USCAA National Championship race on November 11th in Lake Placid, NY. Four men and two women acquitted well of themselves on the technical course held at the Olympic Training Center, site of the 1980 "Miracle on Ice" winter Olympics.
Conditions were cold with temperatures in the low 40s and the course dusted with a light snowfall from the previous night. Run on undulating and technical-footing trails, junior Kati Christoffel (Clifton Park, NY) and sophomore Philip Boody (New Sweden, ME) turned in the top Owls' performances. Christoffel set herself up well early, being in the 15th spot at the half-mile mark, and keeping a top seven All-American finish in her sights. This was Christoffel's first run over the 6 kilometer distance, which factored into her pacing and into her overall race strategy. Continuing to work over the next 2.5 miles, she was in 10th position with 0.73 miles to go, 27 seconds back of the last All-American spot. With 500 meters to go she had worked up to eighth place and 17 seconds back. Although unable to continue to close, Christoffel held on to the eighth position in the 111 women field despite a late charge by the ninth place finisher. Her 26:34 was her best performance of the year. Boody also turned in his best race of the season with an 8 kilometer time of 29:47, good enough for 17th spot in the 149 man field. He got out well and was 27th at the two mile mark before beginning to move up through the field. At mile four he was 23rd and ran the balance of the race very strongly, picking up six more positions. He and Christoffel will anchor next year's teams as the stronger returning veterans.
Senior Justin Fereshetian (Turner, ME) finished in 33rd spot at 30:58. Fereshetian caps a stellar UMPI cross country career by going to a national championship for the third time. Freshman Dan Dermody (Cheshire, MA) and sophomore Richard Landry (Shubenacadie, Nova Scotia) finished 63rd (32:43) and 144th (42:01), respectively. Freshman Emily Wright (Mapleton, ME) ran to 38th spot with a time of 28:47.
The Owls' performances indicate good things to come for 2012 as the returning athletes will be the foundation for anticipated improved team performances. According to Coach Chris Smith, "this USCAA meet may be smaller than other national championships we have attended but it is extremely competitive. We'll have to be at our best in future years in looking to compete in the top half of the field. This is not beyond our capabilities. By staying active this winter and participating in our outdoor track schedule in the spring, our current runners will be well on their way to matching and exceeding performances of this year. New recruits will bolster our chances of placing well in Lake Placid next November".


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Polysciences has been the leader in supplying epoxy embedding material to microscopists for many years. Our Poly/Bed® line of products are the reliable, long-established means by which you can be assured of secure specimen embedment. Use Poly/Bed® for your scientific studies requiring beam stability, low shrinkage, and good contrast. Poly/Bed® Epoxy formulations are of lower viscosity then Araldite formulations, and hence provide better penetration into tissue samples.
Kit Contains: 1x50ml Poly/Bed 812, 1x30ml DDSA, 1x20ml NMA, 1x5ml DMP-30
- Reference(s):
Rudmann, Daniel G., MCNerney, Mary e., Vandereide, Stacey L., Schemmer, Joyce K., Eversole, Robert R., Vonderfecht, Steven L. (2004) Epididymal and Systemic Phospholipidosis in Rats and Dogs Treated with the Dopamine D3 Selective Antagonist PNU-177864, Toxicologic Pathology 32:326-332
- Hazards:
- Corrosive
, Irritant
, Skin sensitizer
, Toxic (Ingestion)
- Handling:
- Glove, chemical goggles & chemical mask or hood
- Storage:
- Store at room temperature


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- You must have approval from the wholesaler/manufacturer to run a co-op.
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Additionally, the following guidelines will be in effect for the co-ops in general.
The number of co-ops running at any given time will be limited. However this limit will vary - it will depend on how complicated the current co-ops are, how busy the designated co-op moderators are as well as other factors.
Keep in mind you may be told you cannot host a co-op at the time and may be asked to wait. Please don't take this personal. This is only to insure that large co-ops can be monitored before getting out of hand.
We urge ANY member interested in hosting a co-op to evaulate their time and the events going on in their life. Running co-ops late in pregnancy, near the time of a move, in a time of financial or family trouble, etc is generally a very bad idea. If you unexpectedly find yourself in such a situation, we urge you to pass on the time and energy intensive responsibilities (such as sorting and shipping) to your co-host. Nobody likes the feeling of having to "give-up" or pass on their responsibilities to another person, but when taking on the task of dealing with other participants money, its best to put your feelings aside and do what will give the particpants a sense of security.
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March 20, 2018 - The Flats at Eutaw Place Groundbreaking
March2018TheFlatsEutawPlaceGroundbreakingThe Flats at Eutaw Place Groundbreaking
Photography by: Mark L. Dennis and Jay L. Baker
Privacy Policy
Terms of Use
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Phone (410) 396-3835Fax (410) 576-9425
Copyright © 2014 City of Baltimore & Catherine E. Pugh, Mayor.
All Rights Reserved.
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IF THE FIRST decade of the 21st century began with the Supreme Court's Bush vs. Gore ruling that selected a U.S. president, it ended with another decision that was also conspicuous as a departure from long democratic precedent. And like Bush vs. Gore, it was a case of judicial activism tilting the electoral system toward conservative interests and outcomes.
The Court's 5 to 4 decision in Citizens United vs. Federal Election Commission on Jan. 21, 2010, allowed the use of corporate and union money in unlimited sums to influence election campaigns. Citizens United was, all at once, a truly remarkable piece of judicial activism, a precedent-shattering evisceration of a century-long tradition of limiting corporate power in American politics, a break with the republican tradition's well-founded fear of political corruption, and a direct interference with the electoral rules in a way that favored those who had put the conservative justices in a position to make the ruling in the first place.
The case arose when Citizens United, a conservative group, brought suit arguing that it should be exempt from the restrictions of the 2002 McCain-Feingold campaign finance law for a movie it made that was sharply critical of Hillary Clinton, at the time a presidential candidate. The organization argued that, as a First Amendment matter, it should not be required by law to disclose who financed the film.


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Jordan Moore
Thanks for sharing a great lesson in content choreography Rachel. Grids in CSS was something I looked at briefly (and prompty ran away from because it looked scary) before I played with source order using flexbox (http://www.jordanm.co.uk/post/21863299677/building-with-content-choreography).
Your experiments with grids are much more powerful than the flexbox approach to altering source order, it seems to offer finer control over the end result. Kudos to you for making a complex topic easy to understand and follow!


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Although the government officially withdrew from its battle against Apple Monday, many observers sense the tech privacy war is just getting started. "This lawsuit may be over, but the Constitutional and privacy questions it raised are not," Congressman Darrell Issa (R-Calif.), who had criticized the Justice Department's suit against Apple, said in a statement Monday. The Justice Department withdrew its legal action against Apple after a method brought to the FBI earlier this month by an unidentified entity allowed investigators to crack the security function without erasing contents of the iPhone used by Syed Farook, who with his wife, Tashfeen Malik, carried out the December mass shooting in San Bernardino that left 14 dead.
The government maintained it was looking for access to one phone, but Apple countered that asking for a code that could access the iPhone 5c would create a backdoor to all such devices that was exploitable by other entities. "This case should never have been brought," Apple said in a statement released late Monday. "We will continue to help law enforcement with their investigations, as we have done all along, and we will continue to increase the security of our products as the threats and attacks on our data become more frequent and more sophisticated. … This case raised issues which deserve a national conversation about our civil liberties, and our collective security and privacy."
In its two-page filing in a California magistrate's court, the government noted that due to outside assistance it "no longer requires the assistance from Apple Inc." Justice spokeswoman Melanie Newman said the FBI is reviewing the contents of the phone as "consistent with standard investigatory procedures," and that "we will continue to pursue all available options for this mission, including seeking the cooperation of manufacturers and relying upon the creativity of both the public and private sectors." Government law enforcement officials have denied charges the FBI wanted to establish a backdoor to Apple's encryption, and swatted away accusations that they were using the case to gain broader access to consumers' devices.
"The San Bernardino case was not about trying to send a message or set a precedent; it was and is about fully investigating a terrorist attack," FBI Director James Comey wrote in an editorial last week. The FBI has about a dozen similar cases pending in which it wants access to smartphone information to assist with a case. So while this particular showdown may be over, "there are other cases pending where law enforcement relies on the All Writs Act" to access tech gadget data, referring to an old law that can compel companies to help the government in pursuit of its duties, says Denelle Dixon-Thayer, Chief Legal and Business Officer at Mozilla, the company behind the Firefox browser. "This question is clearly not going away just because the government has withdrawn their request in this particular case," she says.


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Otsego County Courts
|Oneonta City Criminal Court:
Notice of Appeal
|Affidavit of Service
|List of Available Transcription Services
|Bail Affidavit
|Release of Information Form
|Credit Card Authorization Form
|Oneonta City Parking Tickets:
|Parking Ticket Application for Review
|Oneonta City Traffic Court:
|Guilty Plea Form
|Not Guilty Plea Form
|Credit Card Authorization Form
|Otsego County Family Court:
|Identification Sheet (HTML)
|Otsego County Surrogate's Court:
The OmniForm version of our forms can be filled out electronically. To access them, you will be asked to install a browser plug-in from ScanSoft. Please keep in mind when completing OmniForms that "the text of all papers must be legible and, other than prompts and instructions, must be in a standard typeface of 10 to 12-point characters and have margins" [22NYCRR Section 207.4]. The typeface becomes smaller as more information is inserted therefore additional pages MUST be attached when available space is insufficient, i.e. typeface becomes too small to be legible.


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How the browser MMO and CodeIgniter Hacked
This one is intended to be an educational/tutorial post on how I hacked an MMORPG web browser Persian game known as
Removed From Text and along with it, the well known PHP framework CodeIgniter used for developing it. Reading this might help you learn a thing or two about information security.
First of all, you're not encouraged at all to do anything against
Removed From Text.com or any other CodeIgniter powered website using this technique or any equivalent technique. I am a world-class professional hacker and it's practically impossible to track my actions in the Internet, I use well implemented anonymity/privacy networks and BOTNETs to perform my tasks and infiltrate systems in a way that's very hard to detect.
Defacing any website - for any purpose - and/or stealing its private data it's a felony in international treaties and therefore is condemned highly. The intent of this article is only educational.
* * *
Finding the vulnerability
A few days ago, I visited
Removed From Text to play an online web-based browser game which is purely Persian. I was well aware of the game and it's developers, since I was the coordinator for their participation in 3rd Digital Media Fair of Tehran. I played for a while, and started thinking this might take a long time, so I decided to cheat.
Probing the site and its features for a while, I figured a SQL Injection vulnerability in it's "Forgot Password" feature. It's worthy of note that SQL Injection vulnerabilities are usually found in the least attended, most obsolete sections of a website. Like a small polling dialog, or a forgot password dialog.
The vulnerability which can be seen at http://
Removed From Text.ir/main/forgetPassword by entering foo as username and 1' morgh as the password, brings up the following dialog at http://uc. Removed From Text.com/index.php/forget/index :
A Database Error Occurred
Error Number: 1064 You have an error in your SQL syntax; check the manual that corresponds to your MySQL server version for the right syntax to use near 'morgh'' at line 1 SELECT `uid` FROM uc_users WHERE username='foo' and email='1' morgh' Filename: /var/www/universalcommander/models/forgetmodel.php Line Number: 17


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The following states have passed laws decriminalizing certain marijuana possession offenses. Typically, decriminalization means no arrest, prison time, or criminal record for the first-time possession of a small amount of marijuana for personal consumption. In most decriminalized states, these offenses are treated like a minor traffic violation. Additionally, over 50 localities in a dozen states have enacted municipal laws or resolutions either fully or partially decriminalizing minor cannabis possession offenses.
* Voters in each of these jurisdictions have subsequently approved legislation legalizing the adult use and personal cultivation of cannabis.
**These states still classify marijuana possession offenses as criminal misdemeanors, but the offenses do not carry any threat of jail time.
*** New Mexico's law takes effect on July 1, 2019.


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Is there really a market for this thing; I can't imagine having such an intrusive thing in my living room...
Microsoft to unveil 30-inch touch screen computer - May. 30, 2007
Microsoft to unveil 30-inch touch screen computer - May. 30, 2007
Microsoft unveils coffee table 'surface computer'
Software maker will introduce a coffee-table-shaped computer that has a 30-inch display, allowing people to touch and move objects on the screen.
May 30 2007: 2:42 PM EDT
SEATTLE (Reuters) -- Microsoft Corp. will unveil a coffee-table-shaped "surface computer" Wednesday in a major step towards co-founder Bill Gates's view of a future where the mouse and keyboard are replaced by more natural interaction using voice, pen and touch.
Microsoft Surface, which has a 30-inch display under a hard-plastic tabletop, allows people to touch and move objects on screen for everything from digital finger painting and jigsaw puzzles to ordering off a virtual menu in a restaurant.
Microsoft's coffee-table-shaped "surface computer" hopes to one day replace the mouse and keyboard with voice recognition, pen and touch.
It also recognizes and interacts with devices placed on its surface, so cell phone users can easily buy ringtones or change payment plans by placing their handsets on in-store displays, or a group of people gathered round the table can check out the photos on a digital camera placed on top.
Microsoft (Charts, Fortune 500), the world's largest software maker, said it will manufacture the machine itself and sell it initially to corporate customers, deploying the first units in November in Sheraton hotels, Harrah's casinos, T-Mobile stores, and restaurants.
Microsoft's 150-lb computer: What's the point?


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Designer: ic! berlin
Shipping: Free FedEx Worldwide!
Designer: ic! berlin
Shipping: Free FedEx Worldwide!
Product Description
About the ic! berlin Pulseic! berlin is a German company which designs and produces high-end, handcrafted eyewear in Berlin, Germany. ic! berlin produces eyewear from 0.5mm thick stainless spring steel sheet metal, using a patented hinge design which avoids the use of any screws, welds, or glue in the construction of their frames. The combination of materials and techniques allows their products to be light and flexible. All ic! berlin sunglasses come standard with UV400 Protection and AR Coated lenses.
Availability: Please note, ic! berlin eyewear is handmade in Berlin. If we do not have the frame you desire in stock it can typically take 1-2 weeks to receive. We always recommend contacting us to inquire the availability of the frame you desire, if you need it by a certain time.
Available Colors:Black/Chrome with Green Polarized Lenses
Marine Blue/Chrome with Moonlight Polarized Mirrored Lenses
Dark Green/Chrome with Silver Mirrored Lenses
Yellow/Chrome with Black Lenses
View a PDF of the ic! berlin Catalog
Read more about ic! berlin eyewear
Watch a behind the scenes video of ic! berlin
Watch an instructional video on ic! berlin eyewear
Warranty Information
Add Lenses
Below simply choose the lens material, vision type, and/or any options you desire for your new lenses. Once you have made your selection click the + Add to Shopping Bag button and both your lens options and your frame option will be added to the shopping bag.
At the bottom of this section you can input your prescription. You have the option to either upload your prescription (recommended), input your prescription in the fields provided or click to provide it to us at a later time.
You can also always Contact Us with any questions you may have or for our professional lens recommendation, which is determined by your prescription.
Please click HERE to read all about the lens options we have listed below!
All prices include both lenses.


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Major Players are Infinera Corporation (U.S.), NeoPhotonics Corporation (U.S.), Oclaro (U.S.), Luxtera (U.S.), Kotura (U.S.), OneChip Photonics (CA)
(PRWEB) September 15, 2013
According to a new market research report "Photonic Integrated Circuit (IC) & Quantum Computing Market (2012 - 2022): By Application (Optical Fiber Communication, Optical Fiber Sensors, Biomedical); Components (Lasers, Attenuators); Raw Materials (Silica on Silicon, Silicon on Insulator)" published by MarketsandMarkets, the total market is expected to reach $1,547.6 million by 2022, at a CAGR of 26.3%.
Browse 104 market data tables with 30 figures spread through 236pages and in-depth TOC of "Photonic Integrated Circuit (IC) & Quantum Computing Market (2012 - 2022): by Application (Optical Fiber Communication, Optical Fiber Sensors, Biomedical); Components (Lasers, Attenuators); Raw Materials (Silica on Silicon, Silicon on Insulator)".
Early buyers will receive 10% customization on this report.
Photonic integrated circuit (also known as planar light wave circuits or integrated optoelectronic devices) is a ground breaking technology that has revolutionized the optical network industry. Its ability to process large amount of data at huge speeds makes it an important contributor in enhancing the transmission capacity of optical fiber communications. PICs have changed the dynamics of the optical network industry by increasing optical performance and reliability while reducing physical size, power consumption and heat dissipation. Presently 500 Gbps PICs have been developed to deliver high-capacity transmission while optimizing power, cooling, space and operational simplicity. PICs are being developed for other applications like optical sensors, quantum computing and biomedical. Quantum computing is forecasted to be commercialized by 2017. It will take the market by storm from the moment it gets launched. It is predicted to grow at a phenomenal rate of 139.6% from 2017 to 2022.
The report gives a brief about the evolution of Photonic integrated circuits. The emergence of silicon photonics has changed market dynamics as it has enabled large scale production of PICs at low cost. Presently the market leaders are developing medium and large PICs capable of incorporating 100-1000 components/functions in a single InP based monolithic substrate.
This report describes the various types of integration techniques used to fabricate PICs. The integration techniques include module, hybrid and monolithic. The report covers the market of PICs based on these integration techniques across North America, Europe, Asia-Pacific, and ROW. The market is also segmented according to the raw materials used to develop PICs. The raw materials consist of Lithium Niobate, Silica on Silicon, Silicon on Insulator, Indium Phosphide and Gallium Arsenide. The report also throws light on the PIC market according to various geographical regions. The geographical region covered here are North America, Europe, Asia-Pacific, and ROW.
Global PIC market is expected to reach $1,547.6 million by 2022, at an estimated CAGR of 26.3%. Presently North America is the biggest market for photonic integrated circuit followed by Europe and APAC. However APAC will emerge as the market leader by 2022 because of the prolific growth of datacenters and access network in that region.
Browse related reports
Micro Servers Market (2013 - 2018), by Processor Type (Intel, Arm, Amd), Component (Hardware, Software, Operating System), Application (Media Storage, Data Centers, Analytics, Cloud Computing) & Geography (North America, Europe, Apac, Row)
Quantum Dots (QD) Market - Global Forecast & Analysis (2012 - 2022)
About MarketsandMarkets
MarketsandMarkets is a global market research and consulting company based in the U.S. We publish strategically analyzed market research reports and serve as a business intelligence partner to Fortune 500 companies across the world.
MarketsandMarkets also provides multi-client reports, company profiles, databases, and custom research services. MarketsandMarkets covers thirteen industry verticals; including agriculture, advanced materials, automotives and transportation, banking and financial services, biotechnology, chemicals, consumer goods, telecommunications and IT, energy and power, food and beverages, industrial automation, medical devices, pharmaceuticals, semiconductor and electronics, aerospace & defense.
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text: Brochure: Precision styli (pdf) File size: 1.93 MB Language: English Part number: H-1000-3304 Download file Education guide for all styli users covering the selection, use of and calibration of styli. This type of file requires a viewer, freely available from Adobe Other languages: 日本語 , Italiano , Deutsch , 中文(简体) , Español Latest videos - Styli Crash protection devices Crash protection devices A video demonstrating the role of a crash protection device if a crash was to occur. [1920 x 1080] [99.0MB] Exhibition video: Renishaw precision styli Exhibition video: Renishaw precision styli Promotional video advertising the range and services that Renishaw precision styli offer. English language [512 x 288] [58.2MB] Disc stylus application video Disc stylus application video A video demonstrating the role of a disc stylus [1920 x 1080] [155.7MB] Hemispherical stylus application video Hemispherical stylus application video A video demonstrating the role of a hemispherical stylus [1920 x 1080] [127.4MB] More new videos Latest items - Styli Poster: Styli Poster: Styli Poster showing popular standard styli and accessories [982kB] Technical specifications: Styli for Zeiss applications Technical specifications: Styli for Zeiss applications No description available [3.2MB] Technical drawing: A-5003-5171 Technical drawing: A-5003-5171 Technical drawing of the crash protection kit, to be used on the web shop [67kB] RoHS Statement Styli products RoHS Statement Styli products Statement confirming that all styli in the standard and special ranges from Renishaw, now comply with RoHS. [950kB] CAD file: A-5004-1967 CAD file: A-5004-1967 CAD file of the A-5004-1967, to be used on the web shop. [27kB] More new items Email me when this file is updated Let me know by email when: Files like this are added or updated This file is updated Didn't find what you were looking for? Tell us what you couldn't find and we will do our best to help


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"Der Golem" is a multipurpose theme done for Concrete5 cms. It is very flexible, has variations of home page, portfolio page, project page, can be used with blog or without blog.
It comes in three colour schemes: red, blue, golden. It comes with 10 page templates + 1 simple page type. It comes with 16 custom blocks like accordion, blockquote, dropcap, tabbed block, styled button, styled lists and many more.
You are welcome to visit About page to get full information what does it include + scan qr code to view it from your mobile.
The theme is packed with various features like sliding panel, tabbed block, masonry based featured articles, css transitions, "paralllaxed" layout without javascript etc.
It fits various screen resolutions, was tested on desktops and mobile, in multiple browsers (even Camino). Again, visit About to view more.
Thank you!


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Put your Readers Straight about Litton, Letter to the Editor, Financial Times by Larry B. Litton, Jr.
Financial Times - June 22, 2010 - By Larry B. Litton, Jr.
© 2010 The Financial Times Limited. All rights reserved
Sir, Your articles about Litton Loan Servicing ("Subprime consumers hit at Goldman" and "US consumers rage against Goldman unit", June 16) distort the truth, omit key facts and create a misleading impression of the company.
Importantly, neither mentioned that Litton has modified or granted trial modifications for more than 100,000 loans in the past two years. That is almost one-third of our total mortgage portfolio.
Litton strives to ensure that our customers are treated with respect and receive a fair opportunity to restructure their payments to levels they can afford. Unfortunately, there are cases where we cannot help customers who do not have the financial capacity to maintain a mortgage, even with a modification. There are also occasions when customers request a loan modification even if they have the financial resources to be able to service their existing loan.
The stories mischaracterise Litton's modification performance. In an interview with the reporter, I explained that Litton is among a group of servicers that grant trial modifications relying on verbal income information from the customer, until recently a standard practice under the Home Affordable Modification Program. A second group of servicers grant modifications only after receiving customers' written income verification. Servicers in the first category, like Litton, have lower conversion rates to permanent modifications because of the frequency of inconsistencies between customers' verbal and written income representations. The articles failed to mention that Litton is among the top-performing servicers, in its group, in converting homeowners from trial modifications to permanent modifications.
The stories make no attempt to put Litton's activities in the context of the broader mortgage servicing industry. Your readers have been given a misleading and incomplete picture and, in the process, have been poorly served.
Larry B. Litton, Jr,
President and Chief Executive,
Litton Loan Servicing,
Houston, TX, US


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Your shopping cart is empty!
ABOUT THE MODA FASHION HANDBAG COLLECTION. The high fashion Moda Collection has taken inspiration from leading designer brands along with the latest catwalk looks. Manufactured to a high standard and only using quality materials, Moda bags are functional, practical and hard wearing. Designers create trend driven pieces to be become firm wardrobe staples.The Moda Collection is affordable, collectable fashion, at your fingertips and as always, you can be assured of getting the latest designs at discount prices from The Bag Shop.
|Clutch Bag


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SPRINGFIELD, Mass. – The 12 members of the Class of 2013 will begin arriving at the Hall of Fame enshrinement ceremony in a few hours, with the ideal backdrop of a forecast of sunshine and temperatures in the mid-70s for the red-carpet walk up the stairs outside Symphony Hall in the rare afternoon start.
This could turn out to be a very memorable affair. It does not have great NBA star power, but Gary Payton and the equally gregarious Oscar Schmidt are going to have a microphone, so probably best to buckle up, and the crowd will embrace the inductions of Jerry Tarkanian and Guy V. Lewis in a time of serious health issues. There could be a lot of emotion in the room.
The election results announced in April and the enshrinement today means a significant change to the list of the most deserving to make the Hall – Payton and Bernard King were 1-2 in the top-10 list in the winter, following the release of the nominees for 2013, and Tarkanian was 6. The late-summer update is particularly fluid, months before the 2014 candidates are announced, and with the usual important disclaimers: This is among people on the ballot and with NBA or ABA ties, not a statement that they definitely belong in Springfield.
1. Jerry Krause, Contributor committee.
2. Tim Hardaway, North American.
3. Mitch Richmond, North American.
4. Spencer Haywood, North American.
5. Bob (Slick) Leonard, ABA.
6. George McGinnis, ABA.
7. Maurice Cheeks, North American.
8. Vlade Divac, International.
9. Paul Westphal, North American. (As a player.)
10. Nick Galis, International. A slight semantics stretch for someone who spent his entire career in Europe to make the list, but Galis was born and raised in New Jersey, played at Seton Hall, and was drafted by and in camp with the Celtics.
The ranking is of most deserving, not the best chance for election. An ABA representative – Leonard, McGinnis, anyone – will be elected through a special voting channel no matter what, probably ahead of some, and maybe several, candidates from the North American category that handles most of the players with NBA backgrounds. Similarly, one 2014 inductee will almost certainly come from the International and Veterans field, though it is not mandatory that voters elect someone.
In a related development, Sarunas Marciulionis said he would be willing to be re-classified from the International committee, his current category, to the Contributor, an unusual move for a candidate but one that could increase his chances. The former favorite with the Warriors, SuperSonics, Kings and Nuggets is a credible candidate via International, but his risky move to break from the Soviet Union to join the NBA and his work behind the scenes to get newly independent Lithuania to the 1992 Olympics are seminal moments in the development of basketball around the world. Until someone officially requests the move to Contributor, though, he remains in International.
One other thing as the ceremony approaches: Schmidt, a star in his native Brazil and also Italy, is at the Hall about 4 and 1/2 months after undergoing brain surgery to remove a tumor, following a similar procedure about two years ago. He said he is in good health – "I'm cured, man" – but also does chemotherapy.
"And now, I am spending everything I gained," he said. "All the money I get. And I get a lot of money. Lots of money, I get."
Schmidt, 55, said he works about eight months of the year as a motivational speaker in Brazil and spends the other four vacationing around the world. While on one of the holidays, while driving in Orlando, Fla., he got word of the Hall election.
"A guy from FIBA called me and said, 'Hey, you are in the Hall of Fame,' " Schmidt recalled. "I said, 'I know. I did that two years ago (with the induction in the FIBA Hall). You don't remember?' 'No, you are in the Springfield Hall of Fame.' I stopped the car immediately. 'Can you repeat.' 'You are in the Hall of Fame in Springfield.' Wow. Legs shaking. This is the best moment of my career."


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Tour the Thaw Gallery of American Indian Art and learn about the masks of Yup'ik culture of the Alaskan tundra in one of our popular programs. Students will learn how celebration and tradition was important to the survival of native cultures. Students will then create masks of their own to take home.
This workshop is also available as a Distance Learning Program.
New York State Learning Standards
Social Studies Standard 3
The Arts Standard 1, 2, 3, 4
English Language Arts Standard 1, 2, 3, 4
Mathematics, Science and Technology Standard 4


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BBC News
- Sri Lanka attacks: Eight Britons killed in explosions
- British woman killed by gunmen at Nigerian holiday resort
- Olympic champion Stott held at climate protest
- Older women exploited by IVF clinics, says fertility watchdog
- Mournes wildfire: Firefighters bring blaze under control
- Extinction Rebellion: Climate protesters 'making a difference'
- Lack of bank account 'costs £500 extra a year' in bills
- Easter Sats revision classes 'a growing trend'
- Two men held over Lyra McKee murder released
- Seventy-six pubs 'shutting per month', but closure rate slowing
- Appeal over 1969 disappearance prompt calls
- Record Easter temperatures in three nations of the UK
- Thunberg: 'Climate fight will never stop'
- Alopecia: I lost my hair aged one
- How making bars of soap 'started my life again'
- Are plants a necessity or a luxury?
- Nottingham midwife saves best friend's life
- London loneliness: Hackney Brocals help men find friends
- Lyra McKee murder: Journalist shot dead during Derry rioting
- BBC News Channel
- Newspaper headlines: 'Innocent lives lost' in 'Easter massacre'
- Earth Day: How to be more eco-friendly in everyday life
- The breast cancer surgeon who got breast cancer
- 'New breed' of influencers changed the game
- An alternative way to capture childhood on your phone
- Why blend? Exploring the art and science of blending
- Military 'museum' in Suffolk man's shed includes 1,200 guns
- Millions using 123456 as password, security study finds
- Inside the school for bullied children
- Avengers Endgame: The Marvel Cinematic Universe explained
- Abused as children, art is their therapy
- Meghan and Harry: All you need to know about the next royal baby
- What is it like to strike rich while metal detecting?
- 420: Seven charts on how cannabis use has changed
- 'You can succeed as a vegan athlete'
- Welsh cheerleader: 'Amputation was best decision I made'
- Climate protests: How do police control demonstrations?
Below we are listing a number of UK job websites that have full-time and part-time job opportunities available in the HAMMOON area.
Fish4 Jobs
JobSeekers (Direct.Gov.uk)
http://api.indeed.com/ads/apisearch?publisher=4773927896266615&q=&l=DT10 2DB&sort=&radius=5&st=&jt=&start=&limit=10&fromage=&filter=&latlong=1&co=gb&chnl=AVUK&userip=220.127.116.11&useragent=CCBot/2.0 (https://commoncrawl.org/faq/)&v=2
Jobs at IndeedWarning: Invalid argument supplied for foreach() in D:\Webvirtual\ANYWeb\www\Wordpress\wp-content\plugins\shortcode-exec-php\shortcode-exec-php-class.php(895) : eval()'d code on line 9
Looking for more jobs...
jobs by


text:
How you can post via email in Blogger
The Mail-to-Blogger feature turns any email account into a blog-posting application. In Settings | Email you can create a Mail-to-Blogger address which you will use to send posts via email to your blog:
To post to your blog via email, you need to configure your Mail-to-Blogger email address in Settings | Email:
The format of the email address is email@example.com. Note that this email address must be kept secret. Otherwise, anyone who gets it will be able to post as you.
Also be sure to specify whether or not you prefer your email posts to publish automatically. If this option is not checked, then your posts will be saved on your account but will not appear on your blog until you log in to Blogger.com and publish them yourself.
Once you have saved your Settings, you can send email to your blog. The subjects of your email letters will be the titles of your posts, and the body of the emails will be the posts themselves. To include an image in your post, you can attach an image to you your email.
Notes: Sometimes email programs append text to the bottom of each sent message; to make sure this cruft doesn't get posted to your blog, put #end at the end of your post.


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United Nations Development Programme's new publication 'Biodiversity: Delivering Results in Europe and the CIS' presents some of the outcomes of Global Environment Facility (GEF) funded work managed by UNDP in Europe and the CIS that aims to conserve biodiversity.
The publication provides closer insight into the biodiversity of different Europe and CIS ecosystem types and outlines the main threats and challenges in the context of climate change. It gives a look at biodiversity conservation and protected areas management from the perspective of different countries – depending on their political and economic situation.
It presents concrete examples on how different aspects of biodiversity conservation and ecosystem management were applied in the region through UNDP supported, GEF financed projects.
The Europe and Commonwealth of Independent States (ECIS) region covers 26 countries and more than 24 million km2 (around 16 percent of the global land surface). It harbours globally important eco-regions, including forests, peatlands, freshwater ecosystems, or ecosystems functioning as a storehouse for globally important genetic diversity for wild crops and eco-systems being home for many valuable animal species.
In comparison to the rest of the world, the total number of species in ECIS region is relatively small, but the percentage of threatened species is large. The most immediate threats to biodiversity across the region, along with land conversion, habitat fragmentation and rapidly expanding recreational use remains unsustainable use and exploitation (often illegal). The world's changing climate represents another growing threat, with major implications for biodiversity and ecosystems.
Read the full publication.


text: Hello. I am now setting up a new vps and i want to move everything from my old to my new. I have set-up everything manual, like account, websites, ftp account and everything, but now i want to move all e-mails from my old server. I am using imap to all accounts so i need to save everything from the server. Anyone know how to do this? (Using dovecot) Thanks! & Happy new Year!


text:
Discovery Clothing
Discovery Clothing, a discount trendy clothing Just in time for the holidays, a slew of new well-known retailers are opening in South Florida. Some of them are pretty new to the South Florida marketóH&M, Trader Joeís, and American Girlówith loyal local customers who are excited to have store locations close to home. Others arenít new to the areaóForever 21, Steve Madden, Calvin Klein, Discovery Clothingóbut are opening new locations or expanding existing stores dramatically, much to the delight of their loyal fan bases. Now South Floridians who havenít been to these stores have even more chances to learn what others know: That these brands can be addictive. Plus, the openings of some of these stores will be pretty cool. Sawgrass Mills is hosting a party with model Lauren Tannehill on Nov. 15 to celebrate its new stores, for example.
Taimy Alvarez, Sun Sentinel
Copyright © 2019, Sun Sentinel


text:
a simple solution to world hunger
Watch Generation Hope
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By Communications team in Update from Magnus
Mary's Meals
24 April 2019
MAGNUS' VIDEO DIARY (Part 2)After a long but rewarding day, Magnus reflects on his experience of meeting a local community where Mary's Meals recently began feeding.
MAGNUS' VIDEO DIARY (Part 2)
After a long but rewarding day, Magnus reflects on his experience of meeting a local… twitter.com/i/web/status/…
13 November 2018
Just £13.90 feeds a child for a whole school year.
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text:
Watch talks from the UX Week 2013 conference.
In 1925 architect and designer, Le Corbusier, laid the foundation for modern design by making a call for humans and products to live proportionally and harmoniously. Sounds good right? He stated that design should act as extensions of our limbs, but he also proclaimed, "the human-limb object is a docile servant. A good servant is discreet and self-effacing in order to leave his master free." While today, we don't talk in masters and servants, 88 years later this paradigm still persists in our relationships with technology— technology has taken on the role of master while we have become the servants. What does the future of human-to-technology relationships look like? What can we do right now in interaction design to begin the journey towards healthy relationships with our software, apps and websites?
Fawn Ellis, Lead Experience Designer at Adaptive Path, will answer some of these relational questions through the lens of social science. She will explain what it takes to create and maintain healthy relationships between humans and how this can be adapted to technology and digital products. She will also pinpoint relational qualities which just haven't been designed for yet. Find out which ones are still needed and thus open the door for future innovations.
Radically Human sits at the intersection of user experience practice and organizational design, coaching leaders and teams to produce useful and profitable products and services. Sarah is a popular speaker at design and UX conferences where she conducts workshops on cultivating a human-centered mindset, design facilitation, emotional literacy in creative leadership, organization design, creativity/design practice, and the intersection of business and design strategy.
Marisa Gallagher is the Vice President of Design for CNN Digital. Joining CNN in September, 2010, Gallagher is based in CNN's world headquarters in Atlanta and reports to KC Estenson, senior vice president and general manager of CNN Digital.
Visit the UX Week Vimeo Channel for our archive of main stage speaker videos from previous years.Click to view
This spring the Exploratorium, a world-renowned museum of science, art and human perception, relocated from its home of over 40 years to a new location at Pier 15 on the San Francisco waterfront. The move was the culmination of over 10 years of planning, design, development, and installation.
Patterns of Play and Interaction Play is the work of childhood, and a lens through which we discover the world. Toy Inventor Bill McIntyre takes a look at essential play patterns from the world of toys and games and explores some ways to use these for building engaging, rewarding and (most importantly) fun interactive experiences.
Brenda Laurel has worked in interactive media since 1976 as a designer, researcher, writer and teacher. She served as professor and founding chair of the Graduate Program in Design at California College of the Arts from 2006 to 2012.
Don Carson is a concept illustrator & designer working in the theme park and computer game industries. Don has worked as a Senior Show Designer for Walt Disney Imagineering art directing projects like Splash Mountain, Mickey's Toontown, and Blizzard Beach.
Europeans, US citizens, San Franciscans, Harajuku girls, West Point alumni, gym members, ex-pats, tourists, Sarasota retirees—from birthplace onward, we use locations to define ourselves and others. In turn, these geography-centric definitions allow us to repurpose maps into increasingly rich encyclopedias: intimate yet vast, historical and current.
Thinking about emotion is like trying to learn how to ride a bike by reading a book. In order to really understand interactions between "users" (a/k/a people), you need to employ your own emotional awareness and emotional experience.
This talk takes us to Improv World, where the principles of improvisation enhance communication and personal creativity. While we're visiting Improv World, we'll live like the locals and practice listening, adapting, failing good-naturedly, accepting and building on ideas in collaboration with others.
Lately, there's a lot of interest in borrowing design techniques from game design. At worst, such approaches mistake games for Skinner Boxes, incentive dispensers that dole out rewards for attention.
Beginning in 1962 at the age of 26 and continuing to the present day, Richard Saul Wurman has been extraordinarily prolific. He's written, designed and published more books than most of us have read, and convened innumerable conferences and meetings.
Effective experiences are no longer about "stickiness," or holding eyeballs for extended durations. This metric has been trumped by the advent of device-based interactions, where brief and emotionally-resonant moments can leave greater impressions than longer, more sustained interactions…as long as their impact belies their brevity.
Design to support behavior change is getting increased exposure as technology has allowed products and services to have a more pervasive role in people's lives. What impact does the ability to passively collect data and present it back in a meaningful way have in people's lives? We are interacting with this data of our everyday lives in new ways.
Being the first person in history to represent the craft of user experience on a US Presidential campaign came with a unique set of challenges, goals, and innovative solutions. I'll share best practices and methods that helped Obama for America build teams that produced winning social, mobile, e-commerce and in person experiences for all Americans.
A practitioner as well as a theoretician, Steven Johnson is the leading light of today's interdisciplinary, collaborative, open-mined approach to innovation. His writings have influenced everything from cutting-edge ideas in urban planning to the battle against 21st-century terrorism.
It's an oft-repeated truism that creativity thrives upon constraints–that without limits, good creative work is impossible. Interaction architects, UX professionals, and interactive workers of all stripes work within constraints, of course–whether using wireframes or hacking Javascript.
Agile development has become a standard practice at many companies. Developers love Agile's emphasis on code quality and sustainable pace.


text:
South Dakota Woman Pleads Guilty in Death of Baby
RAPID CITY, S.D. (AP) - A South Dakota woman accused in the death of her five-month-old baby has pleaded guilty to a felony charge of child abuse and neglect.
Federal prosecutors are dismissing a murder charge under the plea agreement with 31-year-old Kehuanna Poitra, of Wanblee.
Authorities say Poitra failed to properly care for her infant son and seek necessary medical attention, leading to his death in the summer of 2011.
U.S. Attorney Brendan Johnson says Poitra faces at least 10 years in prison. A sentencing date was not immediately set.
Copyright 2012 by The Associated Press. All rights reserved. Material may not be redistributed.


text:
Next year?!
Gah, how am I supposed to ignore my family at Christmas without one of these?
Asus' Eee Pad Transformer Prime, the first Android tablet to be based on Nvidia's five-core Tegra 3 chip, will arrive in Blighty early next year. Asus Eee Pad Transformer Prime The 10.1in successor to Reg Hardware's Editor's Choice high-end Android tablet will come with Android 3.2 Honeycomb pre-loaded, but Asus pledged the …
"Alas, Asus didn't say when such an update might be made available."
Alas, NO one but google knows when ICS code will hit the wild.
Unless you're MOTO or the launch partner of ICS (ie Samsung) there's no knowing when you'll get the code in your hands and that's before you even start gauging just how easy or not it will be to port it.
As a proud TF owner, I can testify that Asus is the fastest most reliable updater of their kit bar none!
As the owner of a first generation linux based eee-pc, I've managed to keep that up to date and still use it.... No thanks to Asus though.
First problems showed up in less than a year when the (out of date at launch) awful version of Xandros Linux couldn't be easily updated to provide a Flash plugin that worked, due to the use of old/incompatible system libraries.
At that point, I just gave up, wiped the SSD and stuck a better Linux distro on there:- Gentoo, believe it or not. Still got that installation on it now, and it's still up to date, although the regular re-compiles of Chromium to keep it up to date take a loooooong time.
I too have an EEE 701 and I effectively bricked it after a day trying to tweak the Asus managled version of Xandros (an OS so bad that even Xandros themselves wanted nothing to do with it). So from then on it was semi-freqently rebuilt with Ubuntu EEE/EasyPeasy. Though the past few years I've used it less and less, moreso when I got my iPad2.
As a precursor to flogging it, I thought I'd rebuild with stock Xandros. The CD/DVD that came with it was a bit trashed so had a look round the web to help out. I found an extremely useful page that told me everything I needed to know (and where to get it) whilst also pointing out how bloody useless Asus are for anything that isn't a BIOS update.
So I'll have to agree. I'm pretty sure Asus will get bored after a few months and effectively abandon any useful support.
I love my Eee Transformer and it seems plenty quick enough with its dual cores of power. The reason I went for the northern tablet was that it offered a really good spec for a great price - my fear is that Asus won't sell many of these because its more expensive than a lot of the competition (namely the iPad). Seems heavy too.
But good luck to them..
My daughter has an Eee Transformer and she treats it rough, but it is still functioning well. Every day she throws it in her backpack and subjects it to two daily bicycle rides and playground breaks to boot.
My wife has an Eee PC netbook and I know for a fact it has fallen from counter tops to a marble floor on at least 17 occasions (yes, I count) and all it takes is a squeeze around the outer edge, to reseat the plastic latches, and it is as good as new!
If the new transformer has similar construction it is recommended.
While it is the fashion: I have an Asus Bamboo laptop which is gorgeous, but I am torn between this and the Toshiba AT200 (whenever that might come out). I worry I might just be waiting for "the next best thing" (TNBT?).
Still, at £499, I think I *can* afford to hesitate because there are much cheaper dual core alternatives.
Considering we got the latest update just five days ago and that ASUS has publicly confirmed the ics update (but declined to commit on time due to release uncertainties) there aren't many other makers that can boast such responsiveness.
I jst feel sorry for the guy above as it seems their eeepc support wasn't as good as for the tablets.
They've put a lot of thought and effort into the Honeycomb experience, as well as decent keyboard integration - not just a gimmicky add-on - it also gets its own updates. Speaking of updates, very good, so looking forward to see if they push ICS as well.
My only bugbear comes with their proprietary power cable and lack of accessories - which to be fair is more the fault of resellers and accessory designers. Replacement cables only available through their online shop. It's a crying shame for this has to be one of the best tablets on the market currently and deserves more uptake.
fyi - I picked up an official ASUS charger/dock cable - 1.5m, a useful .5m longer than the in-box cable - from a retailer here in NZ recently for $30 (15 of your English pounds, approximately).
So the accessories are starting to appear. 3rd parties will no doubt follow.
At least in this case it wasn't merely a question of gouging consumers by forcing them to by a proprietary cable for which a generic cable would do.
ASUS have contrived to pump 15V down their cable, which is what makes the device able to re-charge so much more quickly than certain other similar devices.
If they had stuck to a generic interconnect on both ends they would have had to comply with the specifications attendant with those interconnects, or risk liability exposure when someone uses their ASUS charger to try to recharge some other device only to see it melt or go up in a puff of smoke (not to mention a slap on the wrists from the standards body overseeing the interconnect standard).
Here endeth.
f.t.r I was miffed at the proprietary'ness myself when trying to source a longer replacement/additional cable for my Transformer and had the glimmerings of anger beginning to well up inside me directed at the hardware guys at ASUS ... but I calmed down once I learned why it was proprietary.
And I took comfort from knowing that ASUS were unlikely to leave punters high and dry, and sure enough, longer cables are now appearing in the market place - see other comment.
This is quite simple. Get any usb 3.0 extension cable and you're good to go. It's one of the extra pins of the 3.0 connector that signal the charger of the existence of the tab and it subsequently boosts to the 15V. Otherwise, the charger works as a bog standard 5V/2.1A usb thingy.
A USB 3 extension cable will extend the one cable you get in the box, but if you want/need additional charging facilities without taking that cable with you (or if your original cable goes to the Great Cable Rat's Nest In The Sky) then you still need an additional/replacement, proprietary cable. :(
I've bought quite a number of Asus motherboards, graphics cards, a few notebooks etc. The two reasons I hadn't gone for the first Transformer tablet is
- I actually did not need one (only wanted it)
- I never buy first-gen stuff.
That said, a few of my friends has the first-gen transformer. And of all the Android tablets out there, this one seemed the best. Android 3.x seems teensy bit stuttery at times (when compared to the ipad), but it is way more useful.
I am looking forward to the ICS toting 4+1 core speedy Asus.


text: T.I.M. (tracking interactive mechanism) is a kinetic installation by artist/robot builder Danny Bertner. Using the open source development environment, Arduino along with Processing, Danny uses an OpenCV library (open computer vision ) to track faces of the viewer. The mechanisms behavior is interactive, yet random when the audience "provokes" it (i.e. stepping within range of a photocells value spectrum). Interested in our association with movement and how physical behaviors can provoke our innate behaviors, Danny is aesthetically inspired by early 90's sci-fi animatronics and horror. Watch a video of the installation in action after the jump.


text: Good morning, I have a bunch of nodes that I am trying to kickstart install and I am having some slight difficulties. The nodes are Tyan-2466s w/ Intel E1000 GigE cards and a cheap AGP video card. The machines come up just fine with a RedHat 7.3 boot disk image (bootnet.img) using the on-board NIC. The problem is that I want to configure them to boot and install over the E1000 so I can just kickstart them at any time without swapping around network cables (the E1000 will be the only live interface in the final configuration). I ripped apart the bootnet image and added the e1000.o file to the module directory (compiled and tested on a working machine), but the node would not recognize it on boot. Does anyone have experience with attempting this? Any advice would be greatly appreciated. Thanks, -bill -- dr. bill rankin .................................... research scientist wrankin at ee.duke.edu .......................... center for computational duke university ...................... science engineering and medicine http://www.ee.duke.edu/~wrankin ................... http://cse.duke.edu


text:
Information goes here.
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Welcome toumi
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Umi is a Rhino-based design environment for architects and urban planners interested in modeling the environmental performance of neighborhoods and cities with respect to operational and embodied energy use, walkability and daylighting potential. Since 2012, Umi has been developed by the Sustainable Design Lab at the Massachusetts Institute of Technology with support from a National Science Foundation EFRI_SEED project, the MIT Energy Initiative, the Kuwait-MIT Center, the Center for Complex Engineering Systems (CCES) at KACST and MIT, Transsolar Climate Engineering and United Technologies Corporation. Further tool developed is now also being conducted at the Environmental Systems Lab at Cornell University.
A first public version of Umi was released during a public symposium on Sustainable Urban Design on May 6th 2013 at the Massachusetts Institute of Technology. Version 2.0, which also includes an embodied energy module, was released on November 7th 2014.
Getting Started
Model Setup
Site Statistics
Operational Energy
Embodied Energy (Lifecycle Impact)
Design Accessibility (Walk/Bike)
Urban Daylight
Managing Results
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text:
via press release:
Next All-New Episode Airs Tuesday, November 5, on FOX
FOX has picked up nine additional episodes of DADS, bringing the series to a 22-episode order, it was announced today by Kevin Reilly, Chairman of Entertainment, Fox Broadcasting Company.
"FOX has been looking to break into the multi-camera format for some time," said Reilly. "With DADS, we have an asset that we can grow, and we're looking forward to seeing where the fantastic cast and the creative minds of Seth, Alec, Mike and Wellesley take us the rest of the season."
DADS ranks as one of the Top 10 new series among Men 18-34 and one of the Top 10 new comedies among Men 18-49 and Women 18-34. Across the first three telecasts for which Nielsen Live +7 data is available, DADS is averaging a 2.2/7 rating among Adults 18-49. In fact, in the first 30 days of its debut, the DADS premiere episode has already drawn more than 14.7 million views across Live, time-shifted DVR and Video on Demand viewing and streaming on Fox.com and Hulu.com.
In the next all-new episode, "Foul Play," airing Tuesday, Nov. 5 (8:00-8:30 PM ET/PT), Eli (Seth Green) and David (Peter Riegert) are forced to sleep at the Ghost Child Games offices when bedbugs overtake the loft. Meanwhile, Camila (Vanessa Lachey) gets the lead in a local theater production, and Crawford (Martin Mull) ends up being uncharacteristically helpful, much to the chagrin of Warner (Giovanni Ribisi).
DADS follows two successful guys – and childhood best friends – now in their mid-30s, whose relatively stable lives get turned upside down when their inappropriate, pain-in-the-neck patriarchs move in and overtake their home and work lives.
DADS is produced by 20th Century Fox Television and Fuzzy Door Productions. The series is created and written by Emmy Award-nominated writer/producers Alec Sulkin ("Ted," FAMILY GUY) and Wellesley Wild ("Ted," FAMILY GUY). Seth MacFarlane ("Ted," FAMILY GUY), Mike Scully (THE SIMPSONS), Sulkin and Wild are executive producers. Marc Cendrowski ("The Big Bang Theory") directed the pilot.
"Like" DADS on Facebook at Facebook.com/DADSonFOX. Follow the series on Twitter@DADSonFOX and join the discussion using #dads. See photos and videos on Instagram by following@DadsonFOX.


text:
The Maya HTT Technical Support Team is dedicated to helping our customers resolve any issues or questions they may have
Support Info
Maya HTT Support Hotline
The Maya HTT Technical Support Team is dedicated to helping our customers resolve any issues or questions they may have. Contact one of our engineers:
Via Email: firstname.lastname@example.com
Via Phone: + 1.800.965.4842 (US and Canada) or + 1.514.369.6292
Via Support Desk: (Coming soon!)
Hours of Operation:
Telephone support is available Monday to Friday from 8AM to 5PM (Eastern Time). At other times, please send your technical support inquiries directly to email@example.com and one of our Technical Support Team will respond in a timely manner.
You must have an active maintenance contract to enjoy any support (specify SoldTo number or Installation number with all inquiries).
To inquire about maintenance contracts, please email us.
Siemens PLM Global Technical Access Center (GTAC)
Siemens GTAC provides software support through telephone and electronic access. Please see the GTAC website for more details: www.siemens.com/gtac
Access Support for BuildIT
For support of BuildIT products, please go to http://builditsoftware.com/en/support.html
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For support of FEMPLY products, please go to http://www.femply.com/Support.html