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Author: LisaQT3
Story: Getting Used to You
Part: Getting Used to You
Rating: Everyone
Setting: Pre-HBP
Status: Completed
Reviews: 8
Words: 3,242
Updated: May 18, 2004, 7:06pm
Getting Used to You
Author's Note: A big thanks to PS and especially my betas Theresa and Jen. You girls are great!
Disclaimer: The characters and places in this story belong to the wonderful J.K. Rowling.
Harry Potter shuffled into the Great Hall, surprised to find it barely filled. Glancing at the ceiling, he saw the pinks and gold reminiscent of sunset. Snape must have let him out of Occulmency earlier than usual. But that was to be expected, Harry thought. Tonight was an Order meeting, and Snape probably had other things to do besides teach Harry.
A quick scan of the table revealed that Ron and Hermione had not shown up for dinner yet. Too tired to care where they were, Harry plopped down in the closest seat and rested his elbows on the table. His stomach grumbled. Staring at the empty plates, Harry willed dinner to show up early. When it didn't, he sighed a little and started to practice some Occulmency techniques. Just when he had successful cleared his mind, someone broke into his solitude.
"Harry! I've been looking everywhere for you. You'll never guess what happened!" Ginny Weasley sputtered as she flung herself into the seat next to him.
Harry couldn't stop himself from smiling at her. From her red cheeks and generally disheveled appearance, he guessed she probably had been running around the entire castle looking for him. "You've finally found us a decent pair of Beaters?" he guessed, although it seemed highly unlikely.
Ginny groaned. "I wish. No, this news isn't that good. But it's not bad either. In fact," she added after pausing to think about it, "it is actually very good news. I think you'll really appreciate it at least," she said with a wink. Sometimes Harry wished she wouldn't do things like that. It made him feel awkward.
"Well, what is it?" he asked, trying to hide his discomfort.
Ginny was obviously oblivious to Harry's feelings because she smiled and leaned in to tell him the news. "Ron just asked Hermione to go to Hogsmeade with him next weekend!"
"Oh," Harry said. He looked down at the table, his feeling of discomfort growing. "I know."
"You know?" Ginny asked in disbelief. "But…I mean I overheard him do it and you weren't there."
"He told me last night that he was going to ask her. I guess I kind of forgot about it," Harry explained, even though it was a lie. He hadn't forgot about the talk he and Ron had, although he was trying to.
"But…don't you find it exciting?" Ginny asked in confusion. Harry could see her out of the corner of his eye. She was looking at him curiously and Harry didn't like it.
"I suppose," Harry muttered with a shrug.
"Harry, are you okay?" Ginny asked, reaching out to touch his arm.
Harry pulled away. "I'm fine," he said, looking towards the entrance. Ron and Hermione had just walked in together. Her face was still pink with delight, and Ron looked like he'd just won a million Galleons. They spotted Harry and started to make their way over.
"You are not fine," Ginny said calmly, although Harry could detect some annoyance in her tone. "Harry, you've been acting very weird lately. I wish you would tell me why."
For a brief moment, Harry considered it. But the idea was too frightening. Instead he simply voiced his fears. "What if I did, and you couldn't do anything about it?"
"Just because I won't have an answer doesn't mean you can't tell me," Ginny said in exasperation. "Sometimes it helps just to talk to a friend."
"Yeah, a friend," Harry mumbled feeling more miserable than ever. Thankfully, he was saved from any further response by the arrival of Ron and Hermione.
"Hope we're not interrupting," Ron said, arching an eyebrow at Harry.
"No, sit down," Harry replied quickly, sending Ron a warning look.
Ron ignored it. "You sure you're not busy making any plans? For the weekend perhaps?"
Harry glared at Ron and quickly glanced at Ginny to gauge her reaction. She seemed to have been overtaken with giggles. "Real subtle, Ron," she laughed. "We already know about you and Hermione. Congratulations," she said, giving Hermione a knowing smile as the happy couple sat down.
"Yeah, that's great," Harry added. "We've been waiting for it for years."
Hermione smiled widely, even though Harry could tell the attention was embarrassing her. "How was your Occumlency lesson?" she asked, clearly wanting to change the subject.
"Short," Harry replied. "Snape let me out early."
"Does that mean you're getting better at it?" Ginny asked.
"No," Harry replied. "Well, I mean, I am getting a lot better, which doesn't mean I'm good at it yet. But he cut the lesson short because of the meeting tonight." The food suddenly appeared and the students began filling their plates.
"There's an Order meeting tonight?" Ron wondered as he plopped some potatoes on his plate.
Hermione rolled her eyes. "Yes," she told him flatly. Leaning in towards Harry she asked, "Do you know at all what it's about?" Harry shrugged.
"It must be important," Ginny said, as she poured some pumpkin juice.
"Why?" Ron asked.
"Because I saw Professor Lupin come in earlier. I nearly ran him over on my way to the Great Hall," she admitted sheepishly. "It must be pretty important though if people from the outside are coming in for it."
They descended into silence for a while, contemplating what the meeting could be about. After a few minutes though, Parvati Patil, who was apparently having some sort of female trouble, pulled the girls' attention away. Unfortunately for Harry, Ron seized the opportunity.
"So…" he whispered across the table.
"So what?" Harry gritted back.
"What were you guys talking about anyway?"
"Yeah, nothing."
Ron sighed. "Harry, just ask her. It's really not that hard. I should know."
"That was different," Harry said defensively.
"No, it wasn't."
"You knew she'd say yes."
"I did not."
"Then, you're an idiot," Harry muttered.
"Are you backing out?" Ron said, narrowing his eyes.
"Maybe," Harry replied. "Look, Ron, it was a stupid idea. Ginny and I are just friends."
"So were Hermione and me until about twenty minutes ago."
"You and Hermione were never just friends," Harry snorted.
"I could say the same about you and Ginny. She fancied you for forever-"
"Not forever," Harry interrupted. "For three years. Then she got over it. End of story."
Ron shook his head. "Harry, we're lousy at this."
"At what?"
"This girl thing. We should get another opinion," Ron said, scratching his head. "I suppose I could owl the twins…."
"No!" Harry replied a little too loudly. He glanced over at Hermione and Ginny, but the two were still absorbed with Parvati's problem. "Not the twins," he whispered.
"I know!" Ron hissed excitedly. "Why don't you go find Lupin? You could ask him about it."
"I could," Harry said slowly. Ever since Sirius's death, he'd become closer to his old professor. Hermione had told him it was only natural; they represented to each other what they had lost. And Remus had proved to be easy to talk to, although not as easy to talk to as Sirius. Not that Harry had ever really talked to Sirius about girls.
"Yeah, okay," Harry decided. "I'll go ask him."
"Ask who what?" Ginny asked, causing both Ron and Harry to jump.
"Uh…ask Lupin what the meeting was about," Ron lied quickly.
"You don't think he'll tell you, do you Harry?" Hermione inquired as she rejoined their group.
Shrugging, Harry stood up, his dinner long forgotten. "I'm hoping he'll be able to tell me something."
Order meetings were always held in Dumbledore's office. However, since Harry didn't have the password, he would have to wait in the hallway outside the office's gargoyle entrance. He knew Order meetings could sometimes run long, so he'd stopped by Gryffindor Tower to get his invisibility cloak just in case he was still waiting after curfew.
Settling down outside the entrance, Harry had just realized he should have brought a textbook with him as well when the gargoyle sprang to life and several teachers started to exit. McGonagall saw Harry first and walked over, her face unreadable. "Something the matter, Potter?"
"I, uh, just wanted to talk to, uh…Remus," he said, as the man in question appeared behind McGonagall. Harry clambered to his feet and gave the adults a weak smile.
"It's all right, Minerva. He can walk me out," Remus said pleasantly, although he was eyeing Harry with a modicum of concern. Professor McGonagall nodded her assent, before following the rest of the teachers down the hallway.
"Well, Harry, what's on your mind?" Remus asked when the two were alone.
"I need your advice," Harry said as they started to slowly make their way down the corridor.
"About what?" Remus asked.
"About – Oh never mind," Harry said, thrusting his hands into his pocket. "It's not important."
"It must be a little bit important," Remus told him. There was an awkward silence. Finally Remus asked slowly, "Does it have something to do with the Order?"
"Huh?" Harry replied. "Oh, no. No," he answered with a sigh. "But see, that's what's important. I should be worrying about that. Not some dumb girl."
"Ah," Remus said. "A girl."
"Yeah," Harry confirmed miserably. "A girl."
After a few moments of silence, Remus said, "You know Harry, giving advice is a lot easier when I know what the situation is."
"I know," Harry replied. "Well, I like this girl. But…well, it's complicated."
"Complicated?" Remus asked.
"We have a history. Sort of," Harry explained.
"So, you've gone out with her before?"
"No. But she used to like me when we were younger. A lot. And then I sav-" Harry stopped himself. For some reason he didn't really want Remus to know it who he liked. "Anyway, she stopped liking me a few years ago and now we're friends. And, you know, at first when she stopped liking me, I was glad. It was a relief. But now I wish…."
"You wish it was like before, when you were sure of her feelings," Remus finished for him.
"Exactly!" Harry cried, astounded at how simply Remus was able to state his complex thoughts.
Remus chuckled. "You have no idea how like your parents you are."
"I know, I know," Harry moaned. "I remind everyone so much of my father."
"Yes, you do. But right now, I was thinking about how your mother was in a situation very much like this."
"My mother?" Harry asked in shock. He couldn't remember anyone telling him he was ever like his mother.
"Are you familiar with the circumstances that led to your father's appointment as Head Boy?" Remus asked suddenly.
"Huh? Oh, uh no," Harry answered, thoroughly confused by the change of topics.
"Ah, well, at least you know about the prank that was pulled in our sixth year?"
Harry thought for a moment. Hadn't his father and Sirius pulled a lot of pranks every year? Harry wasn't sure he'd heard the specifics on any of them. Except for…Harry nodded slowly, remembering how his father had rescued Snape after Sirius's joke had gone sour.
"Well, the headmaster felt that it showed a great strength of character on James's part, risking his life for his rival's. And since James and I faired evenly in academics, Dumbledore awarded your father the position of Head Boy."
"You mean, my dad stole Head Boy from you?" Harry exclaimed in shock.
Remus shook his head. "No, Harry. I quite agreed with the headmaster's decision. I was truly indebted to James for stopping Severus."
"Oh, right," Harry replied sheepishly.
"I think the incident made your father re-evaluate some of his decisions during his time at Hogwarts, and the appointment as Head Boy only increased his sense of moral duty. A different James got on the Hogwarts Express for our seventh year than any of us were used to."
"I bet Sirius didn't like it," Harry said without thinking.
Remus smiled. "No, he didn't. And neither did your mother."
"She didn't?"
"I think it made her nervous at first. She always knew how to handle your father; how to ward off his advances; and how to dole out the detentions. But the new James didn't act like the old. He was more mature and he respected her. It wasn't long before they were on friendly terms. Of course, I observed all of this from their interactions. But I was to learn later that during that period Lily started to have feelings for your father."
"When'd you learn that?" Harry wondered.
"When your mother told me."
Harry felt his jaw drop in shock. "She told you?"
"I was quite amazed myself. But she felt she needed my opinion. You see Harry, James knew his arrogance and constant advances were never going to sway your mother. So, he gave up and decided to be content with being her friend. So, when Lily started falling for him, she had no encouragement on his behalf. She came to me, I suppose because I was the least likely to tell James about it later, to ask if I thought he was still interested in her."
"And what'd you tell her?"
"That she had to find out for herself."
"What?" Harry exclaimed. "That's cruel."
Remus stopped and gave Harry a funny look. "Why?"
"Obviously my dad was still in love with her. Why didn't you tell her that?" Harry asked.
"Harry, if your mother was truly serious about your father, nothing, not even her own wounded pride, should have kept her from finding out."
"So basically your saying…"
"Talk to this girl. Tell her how you feel. Maybe she's just become very good at hiding her feelings."
"Yeah, or maybe she'll laugh in my face," Harry grumbled.
"If she's truly your friend, I doubt that," Remus replied bemusedly. He laid a hand on Harry's shoulder and looked him in the eye. "And if you really like her, nothing should keep you from telling her. Because there's nothing more difficult to accept than old regrets." Squeezing slightly, Remus let go of Harry's shoulder and continued down the staircase towards the Entrance Hall.
Harry remained frozen on the step, his resolve firming. Remus was right; he had to talk to her. "Remus," Harry called.
Remus stopped at the bottom stair and turned around. "Yes?"
"Thanks," Harry said with a smile. Remus returned the smile as Harry spun around and ran back up to Gryffindor Tower. He had to find her before his nerve failed.
The common room was crowded, but he had little trouble locating her. She was in their usual corner, with Ron and Hermione seated on the sofa next to her. The three were deep in conversation as Harry approached.
"Oh Harry," Hermione said when he had reached the sofa, "did you find out anything from Lupin?"
"He didn't tell me a single thing about the Order," Harry said truthfully as he sat down in a chair across from them. He glanced at Ron, who was obviously interested in hearing what Remus had said on matters other than the Order. "But I did get to chat with him," he said with a poignant look at Ron.
Ron took the hint. "Hey, Hermione, weren't we supposed to do some extra rounds tonight?" he asked standing up.
"Because of the meeting," he told her, grabbing her hand to pull her to her feet. "All the teachers were busy."
"The meeting's over, Ron," Hermione tutted in annoyance, although Harry noted she let Ron continue to hold her hand. "Besides, curfew's not for another half hour."
"Well," Ron said, pulling her towards the portrait hole, "that means we've got half an hour to ourselves then." Hermione quickly protested, but her protests were in vain, because Ron succeeded in getting her out of the common room a moment later.
Moving down to take Ron's place across from Harry, Ginny giggled. "If I ever see them snog, I'll probably have to do a memory reversing charm."
"Yeah," Harry agreed with a laugh. "Me too."
"But I'm glad they're happy," Ginny said contentedly.
"Me too." Harry took a deep breath. "Ginny, I need to talk to you."
Hazarding a glance at her, he saw worry and shock on her face. But there was also curiosity. "You can talk to me about anything," she said honestly.
"I know. And you were right at dinner. Something has been bothering me." He paused, deciding the best way to proceed. "I – I was wondering if maybe you'd like to go around Hosgmeade together next weekend."
"Oh, Harry," she muttered, sounding very much like she pitied him. Harry felt his heart sink a little. "Of course I'll go around Hogsmeade with you."
"You will?" Harry asked confused, although the words buoyed his spirits.
"Yes. But you know, just because Ron and Hermione are going out now, that doesn't mean you're not still their friend."
"What? Ron and Hermione?"
"It's okay to be upset, Harry," Ginny continued. "But I'm sure the next Hogsmeade weekend will be back to normal with the three of you together again. Just give them some time to get used it to. And until then, you can always spend time with me or Neville or someone."
Harry blinked. "Ron and Hermione have nothing to do with this," he said bluntly.
"They don't?" Ginny asked in confusion.
Shaking his head vehemently, Harry continued, "What's been bothering me lately has to do with you. And me."
"Oh," Ginny said quietly.
"So, when I asked you to Hogsmeade," Harry continued, gulping hard, "it was because I wanted to spend the day with you. Because I like you…a lot," he added lamely.
The silence stretched out between them and Harry wished she'd just say something. Anything. But when she finally spoke, she didn't say any of the things Harry expected. "You know, when I was younger, I used to imagine you'd say something like that to me."
"Yeah," Ginny said, a smile tugging at her lips. "But we were usually out by the lake, or maybe atop the North Tower. Somewhere romantic, you know?" Harry nodded, although he didn't find the lake or the North Tower particularly romantic. "And the speeches you made? Much more romantic," Ginny said, with a few giggles. Harry eyed her skeptically. "I know," she said solemnly although her eyes were still laughing. "It was all wrong. Not you at all. That's because back then I didn't know you. Not like I do now. Not as a friend."
"A friend," Harry repeated, looking away and trying to keep the disappointment out of his voice.
"Harry, not all friends stay friends," she replied, drawing his gaze back to her. "Look at Ron and Hermione."
"So, what's your point?" Harry asked, now feeling thoroughly confused.
"My point is, I haven't let myself think about anything but friendship with you in a long time, because dwelling on other stuff was entirely too unhealthy for me. So…give me time to get used to the idea."
"And what idea is that?" Harry asked, wanting to be sure he understood.
"That Harry Potter just asked me on a date," Ginny said with a smile.
"As long as you let me get used to the idea that you said yes," Harry replied.
"Agreed," Ginny said warmly.
The End
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Pokemon Black and White 2 Will Gift Players with Deoxys Next Month
Anyone who's still actively playing Pokemon Black 2 or Pokemon White 2 to pass the time before both Pokemon X and Y are released should prepare to make room in their parties for a new member: the Mythical DNA Pokemon, Deoxys!
Thanks to a post on the official Pokemon website, we can now expect Deoxys to make its way into our waiting games on May 8th, 2013.
Pokefans can get their hands on this rare Pokemon through the Nintendo Wi-Fi Connection, or the WFC. As an added bonus, Deoxys will already be beefed up to Level 100 with 4 moves already learned.
If you're a trainer who's interested in making this strange creature your ally, you'll have until May 31st, 2013 to download it, so act quickly.
More details about this special distribution event will be released on May 8th, 2013, so check back with us for more Poke-info.
What do you think about adding this Pokemon to your team? Let us know in the comments below.

subset: commoncrawl


text:
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With his draft-day fate just two days away, West Virginia quarterback Geno Smith has a message for his far-flung critics:
Just want to thank all those so called "experts" who say I can't be an NFL QB. Thursday will be a special day but the work has only begunâ Eugene Geno Smith (@GenoSmith_12) April 23, 2013
Smith has been the torchbearer for a heavily maligned class of signal-callers described by one anonymous NFC evaluator this week as downright "crappy."
For Smith, there's also the matter of a controversial scouting report from Pro Football Weekly that questioned the quarterback's work habits and desire for the game.
"A cross between Akili Smith and Aaron Brooks, Smith is a gimmick, overhyped product of the system lacking the football savvy, work habits and focus to cement a starting job and could drain energy from a QB room," read the report, which drew a response from Smith, who called it "untrue in all things."
Despite the ominous reviews, Smith is bound to go in the first round and will have a chance to prove his critics wrong come September. In the meantime, can we get a Matt Barkley retweet?
Follow Marc Sessler on Twitter @MarcSesslerNFL.


text:
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text:
raser is a valid word in this word list. For a definition, see the external dictionary links below.
The word "raser" uses 5 letters: A E R R S.
Direct anagrams of raser:
rares rears
Words formed by adding one letter before or after raser (in bold), or to aerrs in any order:
b - barres rebars c - carers racers scarer d - darers drears e - eraser searer f - farers h - rasher sharer i - airers raiser sierra k - rakers m - armers rearms n - snarer o - soarer p - parers parser rapers rasper sparer s - rasers t - arrest rarest raster raters starer tarres terras u - rasure urares v - ravers z - razers
Shorter words found within raser:
ae ar are ares ars arse as ear ears er era eras err errs ers es rare ras rase re rear res sae sea sear ser sera
List shorter words within raser, sorted by length
Words formed from any letters in raser, plus an optional blank or existing letter
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List all words starting with raser, words containing raser or words ending with raser
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14-Year-Old Boy From Detroit Shoots His Mother Dead 10 Times As She Slept After She Tried To Keep Him Away From A Gang!
A 14-year-old boy shot his mother 'at least ten times' as she slept on the couch, it emerged today. The teen, named by family members as Joshua Smith, from east Detroit, allegedly unleashed a hail of bullets on Tamiko Robinson, 36, in the early hours of Monday morning, according to a police spokesman. Smith, who was on the swimming team at Kettering High School, was said to be angry that his mother had tried to keep him off the streets and away from a gang.
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text: On Wed, 2002-09-25 at 04:44, James Cownie wrote: > > You cannot use any interconnect today to build 512 nodes > ****** > > You surely mean "You can use ..." ? Jim is totally right. I meant you *can* use any type of pipe to build a such large machine, but you should not use any *topology*. It's the reality that each interconnect is tight to a specific topology today, thus you may extend this limitation from topology to interconnect, but it's only a side effect. Sorry about the lapsus. Patrick -- ---------------------------------------------------------- | Patrick Geoffray, Ph.D. patrick at myri.com | Myricom, Inc. http://www.myri.com | Cell: 865-389-8852 685 Emory Valley Rd (B) | Phone: 626-821-5555 Oak Ridge, TN 37830 ----------------------------------------------------------


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The Virginia Tech Hokies logo display case features an antique mahogany finished base and a 1/8"-thick clear acrylic removable lid engraved with the team logo. It comes with mirrored bottom and back. The case is perfect for a collectible helmet. It is officially licensed by the NCAA. Measures 14.5" x 11 1/8" x 11 11/16". Memorabilia sold separately.
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text:
Yankton School Superintendent Sentenced for DUI
YANKTON, S.D. (AP) - The school superintendent in Yankton has been sentenced for drunken driving.
The Daily Press & Dakotan reports that Joseph Gertsema was fined $350 and ordered to pay $170 in court costs. His driver's license was suspended for 30 days.
Gertsema said after Tuesday's hearing that he was glad the ordeal was over and that he looked forward to spending Christmas with his family.
Gertsema was arrested Oct. 7 at a Highway Patrol checkpoint near Vermillion. He pleaded guilty to first-offense drunken driving.
Gertsema recently announced that he is resigning at the end of next June, after nearly two dozen years as superintendent. He said the decision has nothing to do with his arrest.
Copyright 2012 by The Associated Press. All rights reserved. Material may not be redistributed.


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February 20, 2014
"At the end of this difficult period, there was a seed for
what has been one of most fantastic developments in one field of
neuroscience"—the identification of nerve growth factor (NGF), said Piergiorgio Strata,
president of Italy's National Institute of Neuroscience,and a member of the
European Dana Alliance for the Brain (EDAB).
The occasion was a memorial
symposium for Levi-Montalcini, a founding member of EDAB who died in 2012
at the age of 103. Neuroscientists who knew, worked or studied with
Levi-Montalcini honored her life by elaborating her legacy—a morning's tour
through research that followed the groundbreaking discoveries for which she
received The Nobel Prize in Physiology or Medicine in 1986.
Working at Washington University in St. Louis after the war,
she and Stanley Cohen (with
whom she shared the Nobel) identified a compound, expressed by peripheral
cells, that attracted spinal neurons and induced neurite formation, then
isolated this substance—NGF—from tumors, snake venom, and mouse salivary
glands—all in the face of relentless skepticism from the scientific community.
Speakers at the symposium, presented by the Italian Cultural
Institute and Centro Primo Levi in NYC, stressed the characteristics that
enabled her to flourish intellectually and prevail in adversity: a powerful,
charismatic personality, enormous drive and passion for her work, and an
approach that combined intuition with analysis. "She often noted that she
viewed herself as an artist more than a scientist," said a Neuron obituary.
The importance of this work, speakers said, could hardly be
overestimated. "If we look at the history of 20th century neuroscience,
Rita ranks with the giants... she was the first major molecular
neurobiologist," wrote fellow Nobelist (and member of the Dana Alliance
for Brain Initiatives) Eric
Kandel, in a tribute read at the meeting. "Her extraordinary discovery
of NGF affected all aspects of our field."
As the first identified growth factor, NGF introduced a
radically new concept, saidLloyd
Greene of Columbia University."We knew from insulin that organs
could communicate via substances that went into the bloodstream. A major
implication of Rita's findings was that there was another means of
communication between cells, at short range." Her inquiry into embryonic development
illuminated key processes in mature neurons—survival, plasticity,
neuroprotection—and beyond, "an explosion of findings within and outside the
nervous system."
Ralph Bradshaw of University of California, San
Francisco, called NGF a "Rosetta Stone" that helped decode key
aspects of nervous system function, proteins, receptors, and cancer biology.
He reviewed some of his involvement in elaborations of the
NGF discovery—beginning with the sequencing, in collaboration with Ruth
Angeletti (who had been Levi-Montalcini's only PhD student, now at Albert
Einstein College of Medicine), of the NGF molecule. The structure, he said,
suggested a compound that acted like insulin on target cells. "It turned
out we were right, but not for all the right reasons."
"The idea that NGF was an endocrine-like substance led to
pursuit of the receptor," Bradshaw said, summarizing research that eventually
characterized not one but two receptors (a fact that "befuddled the field for
15-20 years") and then to elucidation of the molecular signaling pathways by
which NGF and related compounds modulate cellular function.
"The picture started to evolve that these factors were not
only involved in growth and development, but also as regulators in growth
disorders, namely cancer… that these were very important discoveries,"
Bradshaw said.
Greene's research exemplified this importance. "In
science, you start working on one thing and end up with something far different,"
he said. "NGF led us, in ways we never would have anticipated, to a potential
treatment for brain tumors."
It began with studies in the 1990s to explore how NGF
regulates genes. Using serial analysis of gene expression, Greene's research
team identified hundreds of genes that became more or less active after
exposure to the compound. The researchers then focused on transcription
factors—proteins that determine whether genes are turned on or off. They found
that one of these compounds, ATF5, was particularly abundant in neural
progenitor cells, but not in mature neurons or astrocytes, and that NGF shut
down production of ATF5.
"This led us to the idea that ATF5 is important for
proliferation of [stem] cells that eventually give rise to the brain. When they
encounter growth factor, they turn into differentiated cells and stop
proliferating," Greene said. Neural progenitor cells that were experimentally
deprived of ATF5 differentiated prematurely and failed to migrate. Cells
infected with a retrovirus to keep on producing the transcription factor never
differentiated and continued to divide—much like a tumor.
"We wondered: is ATF5 present in glioblastomas?" he said.
It was; cells from 29 of these highly virulent, virtually
incurable tumors all expressed the transcription factor. When the researchers
silenced ATF5 in cultured glioblastoma cells, the cells died.
In subsequent in vivo studies, the
researchers gave mice with experimentally induced glioblastomas subcutaneous
injections of a molecule that hybridized dominant-negative ATF5 protein, which
neutralizes ATF5, with penetratin, a peptide that crosses the blood-brain
Within days of treatment, tumor cells began to die; 19 days
and 6 months later, the tumors had disappeared on MRI. Treated animals all
survived for 6 months, while 60% of the others died. There was no apparent
kidney, brain, liver, or blood toxicity.
As work proceeds with other animals, "we're collecting data
to go to the FDA for possible clinical trials," Greene said. The approach
"could work for other tumors as well."
Cattaneo of the European Brain Research Institute in Rome (which
Levi-Montalcini helped establish in 2002), described research linking the NGF
system to Alzheimer's disease pathology, and suggesting a novel treatment
Using antibodies that target NGF, he showed that
neutralizing the growth factor in the brains of adult mice initiated a process
of neuroinflammation and neurodegeneration. While the effect on cholinergic
neurons—a key population in Alzheimer's disease (AD)—was first implicated, it became
clear that astrocytes and glia were compromised as well.
Further studies characterized this neurodegeneration process
as an imbalance between NGF and a precursor protein, proNGF, and showed that
the same result could be achieved by modifying mouse brain cells to overexpress
Cattaneo has been exploring ways to "strengthen the balance
by increasing NGF." When mice, genetically modified to express AD-like
pathology, were given a modified form of NGF intranasally, amyloid plaques
regressed, and learning and memory deficits improved.
"This may be a viable candidate for a non-invasive
therapeutic approach to AD," he said. "We're collaborating with the
pharmaceutical industry to get clinical trials."
Looking toward the future of NGF-related research, Cattaneo
cited an "agenda" that Levi-Montalcini proposed in 2009, at the age
of 100. In addition to work (like the studies described above) aiming to
develop its therapeutic potential, she urged investigations of the NGF system's
role earlier in embryonic development than the nervous system, and in more
primitive species.
Her agenda called for studies of NGF in other tissues,
particularly the reproductive system. "Rita predicted it would be found to
participate in processes like activation of sperm or implantation of ova,"
Cattaneo said.
Her scientific intuitions were still reliable, he said.
In a paper
published three years later, researchers described their work identifying a
substance in the semen of diverse mammals that induces ovulation. It was NGF.
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The allure of fame and fortune has drawn millions to Hollywood and spawned a veritable industry of books and movies about making it or not in the film industry. "L.A. Without a Map," based on Richard Rayner autobiographical novel, reps one of the tamer riffs on this theme. Essentially a boy-meets-girl yarn, the picture has some warm moments and funny vignettes but overall lacks the bite or wit to deliver more than modest commercial returns. Ancillary biz might be marginally better but the effort definitely represents a missed artistic opportunity.
The personal saga begins in the North of England, where Richard (David Tennant) is the town's undertaker and writes obituaries for the local paper. Barbara (Vinessa Shaw) — an aspiring actress from Los Angeles — stumbles into the village while vacationing and decides to stop. It's not particularly "meet cute" but they're photogenic together and Richard can't get her one-day visit out of his head.
So he packs a bag and hops a plane to Hollywood. Armed only with a matchbook, he shows up at the Japanese restaurant where she waits tables and has told co-workers of the writer she met while touring. It's not exactly the best foundation for a relationship. However, in this world of not-quite-made-its, illusion is a natural way of life.
Richard's Hollywood education is a series of misadventures involving seedy hustlers, fast-talking agents and hot shot directors. He takes it all in without passing judgment, and that passive stance undercuts the potential humor in the bigger-than-life behavior of the crowd he finds himself among.
The material requires the dry whimsy and observation of someone like Bill Forsyth. Filmmaker Mika Kaurismaki is too literal in his approach to Rayner's book, dotting the scene with in-joke cameos from niche Hollywood players and his Leningrad Cowboys co-creations as a shorthand way of tipping his hand that it's meant to be bizarre. For the uninitiated, it will also seem rather impenetrable and disjointed.
The pity is that both Tennant and Shaw are charismatic young performers. One can readily imagine the two creating real sparks in a more sharply realized adaptation. Also making a strong impression is Vincent Gallo as the wheeler dealer landlord of the dive the young man rents and James Le Gros as an obnoxious, plugged-in talent handler whose gut instinct lands Richard on his client roster. Other supporting players score some points but their talents are largely squandered.
The film also suffers from its uninspired visual style, which only serves to reinforce the pic's limited budget and perspective. "L.A. Without a Map" is also L.A. without a script and, in both instances, it's easy to get lost and frustrated.


text:
Governor Deval Patrick on Saturday announced sweeping disciplinary measures against three prison guards and three high-ranking Department of Correction officials for the roles they played in the 2009 death of 23-year-old Joshua K. Messier as guards attempted to restrain him at Bridgewater State Hospital.
Patrick formally reprimanded Correction Commissioner Luis S. Spencer for his inaction in the wake of Messier's death, which was ruled a homicide four years ago. His public safety secretary also called for the resignation of Assistant Deputy Commissioner Karen Hetherson from her $117,000-a-year job for overruling a 2011 Internal Affairs report that cited two of the guards for misconduct.
Patrick placed three guards on paid administrative leave, saying at least two should face disciplinary proceedings for improper use of force against the handcuffed Messier, who suffered a heart attack after guards pushed his chest almost to his knees. The third guard, he said, should be disciplined for failing to properly supervise other guards involved in Messier's death.
"Mr. Messier's death was tragic," Patrick said Saturday. "When tragedies happen during this administration, I expect the responsible officials to get the facts and deal squarely with them. That did not happen here."
Patrick called for a review of the case by Public Safety Secretary Andrea Cabral after a Globe report two weeks ago detailed the suspect circumstances of Messier's death and the state's complete failure to hold anyone accountable for it.
Patrick released Cabral's 28-page review Saturday as the Globe was preparing to publish a story outlining the pattern of delays and misleading information in the state's official response to Messier's death. The Globe found that Bridgewater and state prison officials delayed one report for nearly two years, and failed to produce two others at all.
Within weeks of Messier's death, the Globe found, Bridgewater Superintendent Karin Bergeron was scrambling to avoid providing a written explanation for the incident. She e-mailed a superior at the Department of Correction that a written report outlining the events of the evening of May 4, 2009, held "the potential for disaster here with a document being misused" — especially if it fell into the hands of a disabled persons advocacy group starting to investigate the case.
Bergeron, who is no longer a state employee, told her superior that she would contact state medical regulators about one key report to "see if they would be willing to have a phone conference . . . so that we do not have to produce a document."
In another instance, Bridgewater and state attorneys told a state watchdog agency investigating Messier's death that the guards had been cleared of wrongdoing by a Plymouth County grand jury. In fact, the office of District Attorney Timothy J. Cruz has confirmed that it never presented the Messier case to a grand jury to determine whether criminal charges should have been filed.
The review by Cabral suggests that former correction commissioner Harold W. Clarke set the tone for the state's response to Messier's death when he announced his support for the guards to senior staff in 2010 while the case was still under investigation.
In a meeting just days after Messier's death was ruled a homicide by a state medical examiner, Clarke said, "We take exception to this — everything was appropriately and professionally done," according to minutes of the meeting provided by the Patrick administration. Both Spencer and Hetherson were at the meeting.
Clarke, now director of Virginia's prison system, could not be reached for comment.
In addition to the actions taken against Spencer, Hetherson, and the three guards — who will face separate disciplinary proceedings — Patrick approved a letter of reprimand to current Bridgewater Superintendent Robert F. Murphy.
Patrick's review cites Murphy for delaying delivery of a required report on the use of force in Messier's case to the Department of Correction's Special Operations Division until December 2012, nearly two years after he was told State Police had concluded their investigation into the matter.
The review also cites Spencer for failing to act after the Special Operations Division cited the guards in January 2013 for violations of department policies, including one that prohibits guards from putting their weight down on a restrained inmate's back, even if the inmate is resisting, because of the risk of suffocation. The Special Operations report clearly contradicted Hetherson's earlier finding of no wrongdoing by the guards.
Patrick's investigation of the response to Messier's death was prompted by a Feb. 16 Boston Globe investigation reporting that guards, medical personnel, Bridgewater administrators, and department officials had violated more than a half-dozen laws, regulations, and hospital policies while handling Messier and responding to his death.
The Globe's story reported that two of the officers suspended by Patrick — Derek Howard and John C. Raposo — improperly applied pressure to Messier's back. The story also said most of the guards involved in Messier's death had little or no training in mental health disorders, or in the application of four-point restraints.
Advocates for the disabled and prison inmates said they were appalled at the lack of accountability on the part of state officials, despite videotaped evidence that guards used a banned tactic on the handcuffed Messier known to cause suffocation.
Christine M. Griffin, executive director of the Boston-based Disability Law Center, the disabled persons advocacy group Bergeron mentioned her e-mail, said her agency regrets its decision not to launch a full-scale investigation of the Messier case in the mistaken belief that state investigators could manage it properly.
"We just incorrectly assumed there were so many people involved that the right thing was going to be done and the truth would come out," Griffin said. "This is a good lesson for us as a protection and advocacy organization: Don't stand down, just get in there."
Messier, a paranoid schizophrenic, was sent to Bridgewater for a psychiatric evaluation by a district court judge after he was charged with three misdemeanor counts of assault and battery following two incidents in the psychiatric unit at Harrington Memorial Hospital. He died a month later at Bridgewater after an altercation with a corrections officer led to guards securing him spread-eagle to a bed in four-point restraints.
The Department of Correction's Internal Affairs Unit concluded in 2011 that Howard and Raposo violated a prison policy that says guards shall never put pressure on a restrained inmate's back. Surveillance video shows the two guards pushing down hard on the handcuffed Messier's back, forcing his chest toward his knees, a maneuver sometimes called "suitcasing."
But Hetherson, the assistant deputy commissioner, set aside that finding, writing in her executive review that "no misconduct was found against staff."
A month later, the state's Disabled Persons Protection Commission — a separate state agency — concluded that Howard and Raposo were responsible for Messier's death, recommending discipline for the two guards, "up to and/or including termination."
An attorney with the Department of Correction and one for Bridgewater State Hospital appealed those findings, asserting that the two guards had been cleared by a grand jury.
"The lack of wrongdoing on the part of the two officers has been confirmed by the investigation of the Plymouth District Attorney's Office and subsequent grand jury proceedings," the attorneys wrote.
But Cruz, the district attorney, never presented evidence in the case to a grand jury, his office said, despite the official homicide finding by medical examiner Mindy J. Hull.
Cruz's office told the Globe that Hull, in a private conversation, unofficially told investigators that she had pulled back from her official findings and now believed Messier, by resisting the guards, was responsible for his own demise. Hull has declined to comment on Cruz's claim.
Meanwhile, Bridgewater officials sought five extensions to produce a so-called "use of force package" that was supposed to explain and justify the guards' use of force on Messier. When they asked for the fifth extension, in August 2010, Bridgewater officials said they were still waiting for lawyers to determine "if the use of force package needs to be completed or not."
It was not until December 2012, more than 3½ years after Messier's death, that the package was delivered.
Records reviewed by the Globe show that Bridgewater officials actively tried to avoid writing other reports as well, including a mortality review that is supposed to analyze all staff actions associated with an inmate's death. It also found that a doctor responding to an emergency in Messier's cell failed to file a report. Cabral said the department will continue to investigate whether all required reports were completed.
Calling the death of Messier "disgusting," Patrick asked Cabral to review the state's response and determine whether department officials complied with all reporting requirements in the five years since Messier died. Messier's family eventually filed a civil lawsuit against the state, Bridgewater State Hospital, the Department of Correction and several individuals involved in Messier's care, as the state's investigations dragged on without result.Michael Rezendes can be reached at firstname.lastname@example.com. Follow him on Twitter @RezGlobe.


text:
Israel News - Stay Informed, Pray Informed
The staff of Israel Today traveled to the Carmel Mountain region in northern Israel this morning for the dedication ceremony of the "Israel Today Forest".
The Jewish National Fund actually plants the trees (many of them beforehand), and welcomed the Israel Today staff with warm words for our readers.
"Welcome to the forest you have sponsored in honor of Israel," said JNF official Eran Avadi. "We work hard to develop the land, especially after the devastating [December 2010 Carmel Mountain] wildfire. And we need your help."
Avadi said that both Jewish and non-Jewish friends, like the Christian readers of Israel Today, "have done much to help us, both in spirit and through generous donations."
Avadi said he was not surprised by the fact Israel Today's readers were willing to help fund forests in Israel, given their great love for the Jewish state.
"Israel Today is giving a different view of Israel that many are missing, and we appreciate that," said Avadi. "Your readers are seeing Israel for what it really is, and we thank them for their help."
Avadi presented Israel Today Editor-in-Chief Aviel Schneider with a plaque reading: "Israel Today Forest - Dedicated in love by the readers of Israel Today in honor of the people of Israel." A metal plague with the same inscription will be mounted in stone at the edge of the 12-acre forest.
Following the plaque presentation, Aviel Schneider expressed his own thanks towards the readers of Israel Today:
"After the Carmel fire, we knew we had to help by planting trees. Every donation (over the past year) has touched me personally and I thank you on behalf of the magazine, the land and the people of Israel."
Aviel said all Israel Today readers are invited to make use of and enjoy the forest, which is situated just south of Mount Carmel in the Ramat Menashe region. (Detailed instructions can be given upon request)
In the meantime, there are still tree certificates remaining for the Israel Today forest. If you would like to be part of this work of restoration in the Land of Israel, click here to buy your tree.
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Aerosmith's New Album Written Except for Lyrics, Says Steven Tyler
While on a press jaunt to promote the new season of 'American Idol,' Steven Tyler dished a little info on the long in the works new Aerosmith album, and it sounds like it won't be all that long till we get our hands on it.
"All of it's been written but I gotta lay lyrics on it and I haven't had a lot of time," he said while speaking at a press conference for the Television Critics Association, "But what I've listened to so far just knocked me out. I know a good song, I know what's gonna get played on the radio." Humbly adding "I'm not that pretentious to say I think we've got hits, but I think we've got something, and that's all that matters."
Aerosmith haven't released an album of all original material since 2001′s 'Just Push Play'. The band began recording material last year while Tyler was doing his TV thang. Famed producer Jack Douglas, who worked on most of the band's classic early albums including 'Get Your Wings', "Toys In The Attic,' 'Rocks' and 'Draw The Line,' assisted the band again this time out. That's a lot of rock history to live up to, but last year guitarist Joe Perry told fans via Twitter, "People have said when we play the rough tracks it sounds like it's from the '70s."
As reported earlier this week, Tyler claims that Aerosmith catalog sales are way up due to his 'American Idol' gig, which starts up for another season on Jan. 18. Will those sales continue to skyrocket? Time will tell, but hey…what d'ya say Steven…let's get that new Aerosmith album going! Put that J. Lo roller skating party a bit lower on your to-do list and you know… rock!


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Night lights of Gloucester.
Image ID: line1344, NOAA's America's Coastlines Collection
Location: Massachusetts, Gloucester
Photographer: Commander John Bortniak, NOAA Corps (ret.)
Category: Coastline/Northeast Massachusetts/
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November 10, 2017


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Some players and coaches on the Chargers thought that the Ravens' fourth-and-29 conversion on Sunday should have been called back because of an illegal block on Ravens receiver Anquan Boldin. The league office disagreed.
The NFL told PFT that Boldin's block on Chargers safety Eric Weddle, which sprung Ray Rice for the last few yards on his incredible 29-yard catch-and-run, was reviewed and found to be legal. Boldin was not fined for the hit.
However, Boldin was fined $7,875 for unnecessary roughness for striking an opponent late on another play.
Ravens safety Bernard Pollard was not fined for a hit on Chargers receiver Danario Alexander, even though the officials on the field flagged Pollard for a hit to the head of a defenseless receiver. The NFL reviewed the tape and concluded that the officials were wrong to flag Pollard.


text:
By Gillian Fawcett, head of public sector, ACCA
ACCA's fourth International Public Sector Conference 'Rebalancing the economy – boosting growth' held on 13 December 2012 focused on what the future holds for the public sector and how to account for it.
In a time when sovereign debt issues are prominent around the world and the measures taken to resolve the crisis have been described as no more than dispensing a 'financial aspirin', the conference provided a timely opportunity to consider how the economy can be rebalanced and how public services can help boost growth. You can view webcasts of the conference to find out more about what a range of high profile speakers had to say on the state of the economy, sustainable public finances and financial reporting.
Speakers included:
- Carl Emmerson, deputy director, Institute of Fiscal Studies
- Gary Gillespie, director and chief economist for Scotland's government
- Mario Marcel, deputy director of the Public Governance and Territorial Development Directorate, OECD
- Fabian Zuleeg, chief economist, European Policy Centre
- Brian Quinn, director, Loan Department, World Bank
- Richard Hughes, economist, IMF
- Alexandre Makaronidis, head of unit – GFS quality management and government accounting at DG Eurostat.
The first half of the conference focused on the economic outlook and trends. We heard from Emmerson that we are in for eight more years of financial pain. Quinn stated that liquidity drying up and the on-going lack of confidence is having a lasting knock on effect. He went on to highlight that inadequate government financial reporting practices have contributed to the depth and longevity of the current downturn. However, he pointed to a ray of hope as governments are beginning to re-examine their financial reporting practices.
The second part of the day focused on how to re-build an effective economy, introduce greater transparency of public spending and explore how public services can contribute to boosting economic growth, both internationally and at local levels. Hughes set the scene by highlighting the importance of fiscal transparency providing clarity and reliability to the public of the government's fiscal policy-making process. All expectations are that the crisis will be lasting, so we need the best possible information about the state of government finances.
Overall, it was positive to see finance professionals, economists and statisticians sharing views on and thoughts on how best to deal with the economic crisis and put public services on a sure footing!


text: All Foods Recipes July 11, 2018 Related Articles 1 Chettinad Mutton Curry 0 Likes! 2 Baked Fish Recipe Indian 0 Likes! 3 Mutton Keema Naan 0 Likes! 4 Garam Masala Powder 1 Likes! Leave a Comment Cancel reply Login with your Social IDI agree to my personal data being stored and used as per Privacy PolicyYour email address will not be published. Required fields are marked * Recipe Rating Comment:* Name:* Email:* Notify me of new posts by email. Don't Miss! random posts .. Burgers and Patties Mutton Minced Patties All Foods R. Likes! 0 Side Dishes Paneer Butter Masala All Foods R. Likes! 1 Ice Creams Cherry Cheesecake Ice Cream All Foods R. Likes! 0 Burgers and Patties Chicken Patties All Foods R. Likes! 0 Facebook All Foods Recipes is home to 500+ of the web's best branded recipes, plus bloggers who share their best recipes! Follow Us Instagram All Foods Recipes is home to 500+ of the web's best branded recipes, plus bloggers who share their best recipes! Follow Us × Join AllFoodsRecipes Username Email Sign up Login to AllFoodsRecipes Username Password Login Lost Password? Reset Password Enter the username or e-mail you used in your profile. A password reset link will be sent to you by email. Username or E-mail Get new password Loading... Don't have an account? Sign Up Already have an account? Login HomeCategory▼AppetizersBeverages▼CocktailsCoffeesJuicesLemonadesMocktailsSmoothiesTeasBreakfastsConfectioneries▼BakesBurgers & PattiesCakes & PastriesDoughnutsFriesPizzasSandwichesTartsDessertsIce CreamsMacaroni & PastaMain CoursesParty FoodsSaladsSide DishesSoupsSteamed FoodsVegetarianWraps & RollsCook Book▼Additional RecipesCanned FoodsFishesMeatsQuick FoodsHealthy FoodsFood FactsTips and TricksBlogPopularLikedMy Account▼Log InRegister


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Yellow Boots is a Disaster Relief Organization made up of three powerhouse grassroots known as Yellow Team, Eden Cares and Boots on the Ground. Our mission is to provide that missing hands on approach to relief efforts. We are a 501c3 that operates out of New York.
Yellow Boots provides disaster relief and humanitarian assistance to individuals and families coping with the aftermath of a disaster, natural or man-made. Through our humanitarian association of volunteers we will distribute resources to foster the effective long term recovery of Staten Island in response to Super Storm Sandy as well as provide a vehicle for disaster preparedness and future emergency responses nationwide. To this end, victims of disaster will get the support and assistance necessary to put their lives back together.