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Grammy Award winning singer-songwriter Marc Cohn has been obsessed with pop music for as long as he can remember: "I was hooked from day one. My older brother had a band that rehearsed in our basement, so I heard Bacharach, The Beatles, Ray Charles, and Motown coming up through the floorboards from the time I was six years old. By the time I was eleven though, the Beatles were breaking up and singer-songwriters were breaking through, and a lot of that music really resonated for me"
1970 was a milestone for Marc – and for pop culture at large, given the unprecedented range of notable artists who made the charts that year. It was the momentous beginning of a new decade, and Cohn himself was moving closer to the precipice of young adulthood. The songs of that eventful year would stick with him forever, the way they would with anyone of a tender age just discovering the deeper meanings and life lessons – the romance, the sex, the sadness, the fun — to be gleaned from a seemingly simple pop tune.
Collaborating with longtime producer-arranger-multi-instrumentalist and fellow Grammy Award winner John Leventhal, Cohn doesn't merely recreate the sounds of this storied time. On Listening Booth:1970, he transforms songs from such artists as Cat Stevens, John Lennon, Paul McCartney, Van Morrison, Smokey Robinson, Creedence Clearwater Revival and even Bread into tracks that are warm, soulful, more than a little sexy and full of easy-going charm. These highly personal interpretations say as much about Cohn's own history – his experiences, his memories, his inspirations – as about the legacy of these songs. They've been so creatively and confidently re-imagined, and sung with such feeling, they practically feel brand new.
Eric: This is a very cool concept for an album, Listening Booth 1970. Why 1970, other than the fact that it was the year that I was born?
Marc Cohn: Of course that was the most important, which most people don't know, so I'm glad you mentioned it. But aside from that, there were also musical reasons for me. It just happens to be the year that maybe 10 of my favorite albums of all time came out. The beginning of the singer/songwriter tradition. The Beatles had just broken up that year but George, John and Paul had each released solo records along with Let It Be. Simon and Garfunkel broke up but released "Bridge Over Troubled Water." James Taylor "Sweet Baby Jane," one of my favorite artists of all time. Van Morrison's Moondance came out, one of my favorite artists of all time and a defining record. The list goes on and on. When we were making the record, we knew that it would come out exactly 40 years after 1970, so there seemed to be some poetry to the timing of it all. John and I, my Grammy winning collaborator as you mentioned, really loved the idea of choosing one year too. We knew the year we were interested in, but just the idea of it not being about the 70s or my favorite songs in general but really just taking a snapshot of the variety that came out in that one amazing year. Then as you say, trying to reimagine some of those songs was really fun.
Eric: What's amazing about all of those artists you mentioned, was that not a lot of them were new in 1970, they already had a few albums out before reaching their legendary status. Do you think that any of those artists you mentioned could have even made it this far in today's music?
Marc: Oh man, those artists? Yeah, I guess there's some of those that would fall under questionable categories but listen, if there's any period of time that Van Morrison, Paul Simon or The Beatles could not have succeeded in, I'm just glad I'm not living in that time. That's all I can say. To me, that's like imagining that Van Gogh would have never found an audience for his art. Those are the masters. I just can't imagine that there would have been an era where they wouldn't have made it.
Eric: Tell me about the first time you heard the playback for "Walking in Memphis" in the studio. Did you know you had a hit?
Marc: No. Not even close.
Eric: Really?
Marc: No, the only thing I had knew I had hit, which was even more crucial for me at the time – the most important part was writing it. I had been a songwriter for years before i wrote that song. I was probably about 25 when I wrote it. It didn't come out until about 5 years after I wrote it. But, I knew that the song was the beginning of me finding my songwriting voice. It was something very different about that song and "Silver Thunderbird" and a few others that I wrote all around the same time where I knew I was beginning to do something original. For years, most songwriters are copying somebody or many people. If you're lucky, you do it enough that you finally arrive at something that seems authentic and singularly you. That's what "Walking in Memphis" felt like to me. It felt like a story nobody else had told, nobody else could have told. That was what was important to me. I felt like I was on to something as a songwriter. I had no idea when we recorded it that we had a hit. If you really think about 1990, and 1991 when that song came out. Mariah Carey and Whitney Houston and people like that ruled the airwaves. So my song was very strange for its time, right? Nobody was sure that it would fit in. In the end that's kind of what's served it, that it was so different and once it got played it stood out.
Eric: I remember in 1992 when Shut Up and Dance released their single "Raving" based on the song. That's how I knew it was a great, lasting song, when it can be accepted by a different audience who loves electronica, transforming it into a rave anthem.
Marc: Right, I know. I wouldn't say that was a revelation for me to hear that. I mean, I loved it that people over the years have covered it. That's the greatest compliment you can get as a songwriter. My moment with this song really was as I said, writing it and when we finally – it took forever to get the recorded version that everyone knows. If you listen to it, it's a very unusual arrangement. The band comes in, the band comes out, it slows down a bit then there's total silence for a few seconds right before I sing "boy you gotta prayer in Memphis." It's a strange arrangement that was all based around my original piano demo and it took a while to figure out how to make a band arrangement of that song work. So, once we got that I was really happy that we were able to figure it out.
Eric: Tell me about the first time that you met Canadian producer Malcolm Burn. He was pretty popular while in Boys Brigade, working with Daniel Lanois, but you know him from his Burning Days album from 1998.
Marc: I did. I was and still am an enormous Daniel Lanois fan. I think he's one of the great producers of all time. In fact, probably 70-80% of my favorite musicians of all time are from your lovely country of Canada. So, yeah, I was just really compelled by Daniel's sound and knew that Malcolm, at that time, was starting to make records without Daniel and I found them equally compelling and I sought him out. I was looking at that time to sort of deconstruct the sound I had built for a couple of records and Malcolm seemed like the perfect person to help me do that. I recorded 2-3, maybe more tracks with him that to this day are some of my favorite recordings I've done. They're very unexpected. They're not the typical singer/songwriter type records. I really like that.
Eric: Who do you love from Canada and why do you think this country has developed songwriters like Joni Mitchell, Leonard Cohen, or Neil Young?
Marc: Those are the ones. That's the holy trinity right there. I'd put Daniel right up there and Robbie Robertson and the list goes on. I don't know, there's poetry in the prairie. Something is going on up there. I even sometimes think Dylan was almost Canadian.
Eric: By only a few miles!
Marc: Minnesota is about as North and cold and prairie like as you can get and still be from America. I don't know. You'd have to tell me, but it's sort of astonishing. How did George, Paul, John and Ringo all end up in Liverpool?
Eric: There's nothing to do, seven months of winter.
Marc: Maybe that's the answer. There has to be some genetic code of brilliance. If cold was the only factor, there would be a lot more incredible writers from Cleveland.
Catch Marc Cohn on tour:
8/11/2015 Yoshi's Oakland, CA
8/12/2015 Montalvo Arts Center Saratoga, CA
8/14/2015 City Winery Napa Napa, CA
8/15/2015 Firehouse Arts Center Pleasanton, CA
8/16/2015 Canyon Theater Agoura Hills, CA
8/18/2015 Belly Up Tavern Solana Beach, CA
8/20/2015 The Coach House San Juan Capistrano, CA
8/21/2015 Saban Theatre Beverly Hills, CA
8/22/2015 The Cave Big Bear Lake, CA
9/19/2015 Southern Westchester Music Fest Mamaroneck, NY
1/16/2016 Smothers Theater, Pepperdine University Malibu, CA


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Team from Animal Hospital of Rhea County wins Charity Golf Tournament May 09, 2014 at 12:00AM
Proceeds benefit We Care Community Services
EVENSVILLE, TENN. May 8 – A team from Animal Hospital of Rhea County won first place in this week's 2014 Charity Golf Tournament benefiting We Care Community Services, which helps people in Rhea County. Animal Hospital's team was comprised of Paul Riggs, Ray Talley, Andy Kelly and Dr. Marshall Taylor. It topped the field at Dayton Golf & Country Club. Second place went to a team from Bryan College, third place to Mike Neal and the Rhea County Sheriff's Department, and fourth place to Community National Bank.Read More

subset: commoncrawl


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The bankruptcy of RadioShack at the beginning of 2015 probably seems like a distant event to you now, but the business entity that used to be the massive electronics chain is still wrapping up its affairs. One of those last pieces of business is the end of gift card redemptions. The Shack's estate will stop accepting requests on Friday, Dec. 2, 2016. [More]
Reminder: Friday Is The Last Day To Redeem Your RadioShack Gift Cards
Woman Arrested For Burglarizing RadioShack That Was Left Unlocked Overnight
A woman in California was arrested for burglary in a RadioShack store (yes, there are still RadioShack stores) but here's the thing: the front door had been left unlocked overnight. Police were summoned because triggered a silent alarm inside the store, and the cops said they found the woman inside when they arrived, taking merchandise. An employee apparently had set the alarm, but forgotten to lock the actual door. [CBS Sacramento] (Warning: auto-play video at that link) [More]
RadioShack Names Second CEO Since Bankruptcy, 10th In Last 10 Years
RadioShack is importing its new CEO from Australia. Their original post-bankruptcy leader quit back in January, and the new president and chief executive officer will take over at the beginning of May. He previously worked at Target Australia (which, confusingly, is not affiliated with the U.S. retailer Target) and was in charge of e-commerce at Sears Canada. [Press Release] [Fortune] [More]
RadioShack's VP Of Stores Keeps Reminding People That It Still Exists
RadioShack declared bankruptcy last February and closed around 2,300 of its stores. Around 1,700 of the company's stores didn't close, though, and the Shack's leaders want you to know that not only are they still around, but they're making progress toward their goal of becoming a neighborhood electronics store. [More]
Nick Cannon Insists That RadioShack Has Always Been Cool
Don't ask rapper and actor Nick Cannon how he's going to make RadioShack cool now that he's their spokesman and "chief creative officer." That, my electronics-shopping friends, is not his job. That's because The Shack never stopped being cool. Got it? They're just marginally cooler now that they have Nick Cannon's own brand of headphones. Yeah, that's it. [More]
Woman Who Stuffed Electronics Inside Her Skirt Returns To Same RadioShack Store, Does It Again
Last spring, a woman wearing a full-skirted dress walked into a RadioShack store in Florida and used the garment to conceal electronics with a retail value of more than $1,100. That was no one-time crime of opportunity, it turns out: people who appear to be the same woman and her male companion were spotted on camera again at the same store, though the items this time were lower value. [More]
Bankrupt Former RadioShack To Pay Its Property Taxes
As the company we once knew as RadioShack winds down its affairs, it's taking care of some important pieces of business. Like paying its taxes. This week, the company negotiated to pay its property tax balances on its former properties in Texas. [More]
RadioShack's New CEO Quits After Less Than 1 Year
At this time last year, we were on RadioShack Bankruptcy Watch, waiting for the venerable electronics retailer to file for Chapter 11 protection. Would it mean the end of RadioShack stores nationwide, or would the brand survive? One of the company's major creditors purchased around half of the chain's stores, creating a new company that would buy the RadioShack name in the bankruptcy auction, and the new RadioShack hired a former Dell executive as CEO in April. Now CEO Ron Garriques is taking off. [More]
Radioshack Franchisee On Martha's Vineyard To Close, Store Dog Will Also Retire
Radioshack's bankruptcy last year led to the closure of more than half of its stores, and the sale of others to one of the company's major secured creditors. Yet the bankruptcy also affected the 700 or so remaining RadioShack dealers and franchisees, including Vineyard Electronics, a franchisee that has kept the island supplied with gadgets since 1981, and is now closing. [More]
RadioShack Executive Wants You To Know That RadioShack Is No Longer RadioShack
When I mention RadioShack, which I occasionally do for some reason, people often express surprise that the electronics chain still exists. That's because they either assume it had shut down years ago, or didn't know that some of the chain's stores survived its recent bankruptcy. Only that's what the people running this new RadioShack want us all to know: the new RadioShack isn't the continuation of the old RadioShack. Maybe they shouldn't have kept the name after all. [More]
RadioShack Starts Black Friday On Wednesday Because Why Not
Let's get this out of the way: RadioShack still exists. While the chain declared bankruptcy and sold or liquidated all of its stores, they sold the brand along with about half of their leases to lender Standard General. That leaves about 1,700 SprintShack-owned stores with their doors still open and stocked with gadgets to sell, some of which may not even be Sprint mobile phones. [More]
Judge Approves Final Plan For RadioShack Bankruptcy
RadioShack's bankruptcy filing back in February probably surprised no one, and it's also not surprising that it has taken almost eight months to sort out the affairs of a company that was 95 years old and had 4,000 stores. While many of the chain's stores were saved and continue under a new owner, and some creditors will be paid in full, the bankruptcy won't end well for the Shack's unsecured creditors. [More]
Radioshack Creditors Claim Pre-Bankruptcy Shenanigans Go Back To Early 2014
The electronics retailer RadioShack had been obviously doomed for a while, finally declaring bankruptcy in February of 2015. Yet lenders kept giving the company money to keep the lights on and keep paying employees to ask for phone numbers and buy extended warranties. Now a group of junior creditors have filed a lawsuit against former Radioshack leaders and the hedge fund Standard General, alleging that this whole bankruptcy was deliberately planned to deliver RadioShack to Standard General at a fire-sale price. [More]
Texas Attorney General Still Seeks RadioShack Gift Card Justice
RadioShack still says that they can't identify the purchasers or the holders of the estimated $46 million worth of gift cards that are still out there for the chain. While there are still RadioShack stores, those are owned by a different company and won't accept the old gift cards. The Attorney General of Texas, Ken Paxton, wants to make sure that gift card holders know that the Shack owes them money. [More]
Texas Attorney General Says RadioShack Knowingly Sold Gift Cards That Would Soon Expire
If the leadership of a company knows that they're about to file for bankruptcy, should they stop selling gift cards? That's what the Attorney General in Texas contends: that RadioShack knew after the 2014 holiday season ended that it would be declaring bankruptcy soon, and that gift cards they had issued would lose their value at the time of the bankruptcy or shortly afterward. Yet they sold 'em anyway. [More]
RadioShack Seeks Relevance Through Wu-Tang Clan Affiliation, YouTube Dance Party
RadioShack is in the middle of a bold retail experiment: is it possible to acquire a venerable brand with a deteriorated reputation through bankruptcy and rehabilitate it into a place where people actually want to shop? The Shack's new owners are harnessing the power of song and dance to try this…well, and also portable speakers. And rap. [More]
Former RadioShack's Lawyers And Lenders Agree To Keep Talking About Settling
Since the beginning of RadioShack's bankruptcy proceedings back in February, the lower-ranking or "junior" lenders in the company's debt pile have claimed that the entire proceedings were full of shenanigans. As the proceedings wind down and lenders and lawyers sort out the final disposition of everything, everyone at least agrees on one thing: the bankruptcy will not convert from a Chapter 11 to a Chapter 7 to save money on lawyers. [More]
There's Still $43 Million In Outstanding RadioShack Gift Cards, And Texas Wants To Rescue It
When a retailer looks like it might be in danger of going out of business, we warn gift card holders to use their cards soon, before the company declares bankruptcy and the cards lose their value. Not everyone has the good sense to read Consumerist, though, and that's why the Texas Attorney General wants the smoldering remains of RadioShack to put aside some money for gift card holders. [More]


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By Jill Warren Lucas
Ten years ago, citizens in rural Haywood County, N.C., located about 30 miles west of Asheville near the Tennessee line, took notice of a group of children who seemed to be out of step with their peers.
The parents of these children, many of whom were either unemployed or worked multiple jobs to make ends meet, could not afford the summer enrichment opportunities available to children of more affluent families. Some did not speak English and were reluctant to ask for help.
"We knew we had to do something to meet their needs," says Lin Forney, a former Pigeon Community Multicultural Center volunteer who launched and still runs its diverse and affordable summer camp. "It wasn't right that some children received so much when others were falling through the cracks."
Children who did not participate in some sort of enrichment program – indeed, who likely spent the summer at home in front of a TV or gaming console – were not as ready for school as classmates who were engaged in organized summer learning, Forney says.
That first summer, 17 students enrolled in the camp, which balances academic instruction with weekly field trips and play time. This summer, 57 youth participated.
Children ages 5-15 are grouped in one of three clusters by age and grade level. Many return year after year and, once they turn 16, are welcomed back as counselors.
"They want to stay involved and give back," says Forney, whose own 16-year-old son spent his first summer working at the camp he'd attended for a decade. "Some help the youngest children, while others tutor children in math and reading. They continue learning, too, about how to take care of children and figure out all sorts of workplace skills."
The teens earned a small stipend for their service, but money is tight at the nonprofit program. Families pay $300 for 10 weeks of camp, including meals and outings. The fee barely covers costs.
"The students that we serve, many of their parents really struggle to come up with that," Forney says. "We're not here to make money. We're here to help the families as much as we can."
Individual philanthropists and organizations help to provide scholarships, especially for families with multiple children who might otherwise have to pick and choose which ones get to attend.
Providing for the least of these is a cornerstone of Pigeon Community Multicultural Center, which is housed in what was the only elementary school to serve African-American children in Waynesville before desegregation. Forney attended the school as a child and her grandparents helped to raise money for its construction in 1958.
"They saw the need for a better facility and, hopefully with that, a better education," she says. "Honestly, it was a draw for me to help build a program there. The vision for the community, then and now, is to make things better for all our children."
In keeping with its social justice roots, the highlight of the summer camp experience is a trip either the Martin Luther King Jr. Center in Atlanta or the International Civil Rights Museum in Greensboro.
"That in itself is a gigantic learning experience," Forney says. "We do a full lesson plan of civil rights and black history. They learn about Dr. King in public school, but here they get to see how all the pieces fit together."
Aquilinia Ramirez's oldest son, Jonathan, now 17, attended the program until he aged out. Her third grader, Marcos, enjoyed his third year as a camper this summer.
"They have a lot of good things in the program, like teach reading and math – and how to eat vegetables," says the Waynesville mother. "He didn't like eating them at home, but he enjoyed working in the garden. Taking care of the plants and watching vegetables grow changed everything."
Ramirez appreciates the support at her kitchen table, but she is especially grateful that her 9-year-old is becoming more engaged reader. "They had some tutors who really helped him. He's not quite on grade level, but he's getting there," she says. "He just started back at school, and he has a positive attitude. He likes his teachers, he has friends in class, and he's ready for the work."
The program requires that parents contribute 10 hours of service (per camper) in support of the program – not just to help stretch a tight budget but also to show their children that it's worth working for things that have value.
"They might help in the classroom or in the kitchen or with our fundraisers, which help to supplement the program," Forney says. "Among the best experiences we have are the family meals, where attendance is required. It's a potluck and, because of the diversity of our families, might mean that you're eating something you've never tried before. Or you might sit down and talk with someone who does things very differently."
Children perform a program to demonstrate new skills, and guest speakers – such as the new CEO of the local hospital and leaders of service programs – engage in conversations about community needs.
"We're not one of those camps where all parents have to do is drop their kids off," Forney says. "We want them all to develop a sense of ownership in our program. We want parents to feel empowered, to know that help is out there."
Forney says many parents are surprised to realize that they can help their children to be more successful in school, even if it's just by modeling the camp's expectations of daily reading and courtesy.
"Parents are happy when they see their children's reading and math skills improve," she says. "More than anything, we see that their self-esteem has been built up. They learn new things, including that it's OK to make mistakes and try again."
Forney says the collaborative nature of camp also helps to build fast friendships that continue in school – a setting where social cliques can to dominate and limit contact with new or different people.
"I think that's a big plus for them. It's good to learn that you may have been wrong about another culture," she says. "And not just for the students but the parents as well. It all comes back to our top priority, which is the learning process. When you are open to new things, your opportunities grow."


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Gusset-less Truss Connection Physical and Structural Model to Aid Bridge Inspection and Condition Assessment
Gusset-less connections reduce the number of bolts required at the bridge and decrease the vulnerability of the connections. However, these innovative connections cannot be assessed using the available tools for load rating of gusset-plate connections for steel truss bridges (Federal Highway Administration (FHWA) Publication FHWA-HRT-14-063). The research study proposed here includes a scale physical model of the connection and extensive laboratory with strain sensors and visualization tools to predict area of concerns over the service life of the bridge. These laboratory results will be combined with field collected structural performance data and analytically-predicted structural performance to create a protocol for inspection, structural assessment and rating of the gusset-less connections. This procedure will be refined to develop a framework to extend this protocol for application to future innovative structural elements.
- Record URL:
- English
- Status: Active
- Funding: $85,000
Contract Numbers:
Sponsor Organizations:
New Hampshire Department of TransportationJohn O. Morton Building
P.O. Box 483
Concord, NH United States 03302-0483
Managing Organizations:
New Hampshire Department of TransportationJohn O. Morton Building
P.O. Box 483
Concord, NH United States 03302-0483
Project Managers:
Scholz, Ann
Performing Organizations:
University of New Hampshire, DurhamDepartment of Civil Engineering
Durham, NH United States 03824
Principal Investigators:
Bell, Erin
- Start Date: 20161001
- Expected Completion Date: 20190331
- Actual Completion Date: 0
Subject/Index Terms
- TRT Terms: Bridge design; Bridge members; Gusset plates; Load factor; Sensors; Service life; Strain (Mechanics); Structural analysis; Structural connection
- Subject Areas: Bridges and other structures; Highways;
Filing Info
- Accession Number: 01601821
- Record Type: Research project
- Source Agency: New Hampshire Department of Transportation
- Contract Numbers: 26962M
- Files: RiP, STATEDOT
- Created Date: Jun 10 2016 3:07PM


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Mother's Day: Sushant Singh Rajput says the first poem he wrote was for his mother
On Mother's Day, actor Sushant Sing Rajput says his mother encouraged him in whatever he did and he promised her that he will always make her smile.bollywood Updated: May 14, 2017 12:30 IST
Sushant Singh Rajput's posts on social media are often dedicated to his mother. Earlier this month, the 31-year-old actor posted a poem on Instagram. He now reveals that the poem was his first ever attempt at "creative writing," remembering his mom, who he lost at the age of 15.
"I wrote the poem when I was in Delhi College of Engineering (now Delhi Technological University). I used to think about her a lot, and this was the first poem. It encouraged me to write more," he says.
Since then, all of Sushant's posts about life are dedicated to his late mother. "I used to read all sorts of books, except my course books (laughs). I was into astrophysics, and somehow I got interested in astrology. Then I started reading Philosophy books. I used to read a lot of (Sigmund) Freud. Whatever philosophy you see on my social media is because of those books, and somehow or the other, all dedicated to mom," he adds.
Sushant, who has a tattoo of five symbols (one of which depicts his mother) on his back, adds, "She was really very close to me and I think so much about her. She encouraged me in whatever I did, and I promised her that I will always keep her smiling. Her death made me introspect about life and I turned into a private person after that."
Follow @htshowbiz for more
First Published: May 14, 2017 11:32 IST


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Speaking Engagements
Sarah Sundin enjoys speaking to community, school, and church groups, and loves to teach workshops for writers. She belongs to the Advanced Writers and Speakers Association.
Use the navigation in this section to learn about Sarah's speaking topics. Please use the Speaking Request Form to ask questions or submit an invitation.
"Your presentation was excellent – with much valuable information, interesting anecdotes, fascinating history, and nicely punctuated with your lovely sense of humor. It was a genuine pleasure listening to your talk."
~ PEO Organization, Pleasanton, CA


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Consumer behaviors and expectations are rapidly evolving, but the rate of change differs across the globe. And while similar attitudes drive the most empowered customers, their device usage varies...
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This report is our annual overview of the impact of technology on US consumers' attitudes, behaviors, and expectations in a rapidly changing world, based on the Forrester Data Consumer...
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Яппаньки вам,уважаем(ый)(ая)(ое)!
"Perhaps you should look at my work."
"I don't have time to learn both your spell language and Isabelle's. I trust in your skill, Galen, in your intelligence and your thoroughness. If I did not, you would not be here. It is your discipline I find lacking."
The criticism angered Galen. He had obeyed the Circle, he had upheld the Code, and she had paid the price. Wasn't that enough? "I have followed the dictates of the Circle."
"And you must continue to do so. We face great danger tonight. If we are to survive to pass our knowledge to the others, we must be of one mind and one intent."
"I have sworn myself to this task."
"As you have sworn to kill Elizar?"
Galen leaned forward eagerly. "Have you found him?"
"Finding him is not our task."
His body was racing again, energy driving through him. The images returned. Elizar's face, turned in fear. Elizar's blood and tech. Galen looked down, and his raw hands closed into fists. "Above all, we must find out as much as we can to ensure the safety of the mages," he said.
When Blaylock did not respond, Galen raised his head. Blaylock's eyes were narrowed on him. "You hold much inside. We all do. It is the way of our order. Secrecy. We all have thoughts of things we must not do, thoughts of destruction. It comes with having power. That is why obedience to the Code is so important. To obey the Code we require control. To gain control we require discipline. In discipline we do what we must, whether we desire it or not. Those of us who follow the ways of discipline reject emotions, desires, physical cravings. We seek to purify ourselves, to attune ourselves not to the flesh, but to the tech. Even then, discipline is never easy. Why do you think so many follow my ways?"
"Because they respect you and they
Предыдущая Следующая


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Numbers of reversible [cellular automaton] rules
For k=2, r=1, there are 6 reversible rules, as shown on page 436. For k=2, r=2 there are 62 reversible rules, in 20 families inequivalent under symmetries, out of a total of 232 or about 4 billion possible rules. For k=3, r=1 there are 1800 reversible rules, in 172 families. For k=4, r=1, some of the reversible rules can be constructed from the second-order cellular automata below. Note that for any k and r, no non-trivial totalistic rule can ever be reversible.


text:
Chuck Stewart's photography provided by Fireball Entertainment Group, courtesy of Chuck Stewart Photographs of John Coltrane, Archives Center, National Museum of American History, Smithsonian Institution
A comic by R. Crumb from our Third Southern Music Issue.
The year was 1960. The author was in his late teens, living with his parents in Dover, Delaware.
A comic from the Seventh Southern Music Issue.
What is an artist's public self but a front, a collection of personal dogmas—brand of whisky, brand of politics, brand of god—perhaps no longer believed in but argued forcefully for the sake of consistency and the benefit of future biographers.
A graphic essay from the Fall 2016 issue.
When European settlers bought Kentucky County, before Kentucky and Virginia split along the Appalachian mountain range, a Cherokee chief warned they were purchasing dark and bloody ground.


text:
Work… work never changes
Howdy Rangers,
It's still early in the New Year and we're coming out of the gates hot!
We recently released the sixth major patch for Wasteland 2, which added Steam achievements for Mac and Linux, cleaned up some issues that were sitting on our lists, and included another pass on text and localization to make sure even the finest details are polished as best they can be. You can read the full patch notes here.
Part of the newfound freedom we've gained from being an exclusively crowdfunded company is that it allows us to offer a high level of post-release support. While this is normal practice for an active multiplayer game, we believe that the ongoing improvements to the single player experience in Wasteland 2 are worth the time and money. The game truly continues to be a passion project for the team here at inXile.
And we're not done yet…
If you've been keeping a close eye on things, you might have heard tell that we're looking at doing some more balancing and improvements of Wasteland 2 in the future. We have expanded our original plan and decided that this is going to be a part of something much larger for all our fans.
In pursuit of this goal, one task we're working on right now is migrating the Wasteland 2 codebase from the Unity 4.5 engine to Unity 5, which will enable some new possibilities for us. A major benefit of moving to Unity 5 is that 5 will include many of the tools from Unity 4.x Pro. We relied on many of these tools during our development (like creating and building navigation meshes), and they will be available to modders without having to pay thousands of dollars for a Pro Unity license. There is no doubt that this migration will allow us to release better tools for modding to our community in the future.
So what's the "something bigger" that I teased earlier? Let's just say that the Orange County lifestyle might be getting to us as the game will be receiving a facelift. Unity 5 offers physically based shading, which is already starting to look amazing in the scenes we've touched up.
As well as visual improvements, we have quite a few quirky tricks up our sleeves. The character system is getting perked up and will include some new elements to modify gameplay. Of course, more details will be released in the future so stay tuned!
The Bard's Tale IV
We've got much more going on at inXile right now than just Wasteland 2. Most of the team, of course, is currently working on Torment: Tides of Numenera, which is shaping up great! But, in addition to that, we're also embarking on some very early technical research and design for our next title: The Bard's Tale IV!
We're a ways out from giving more details on Bard's Tale IV, but it's been thrilling to see the excitement that Brian's announcement at PAX South has brought. His tweet on the topic is his most shared ever, and our posts on Facebook had incredible reach as well, combining for over 200,000 views, 2500 likes and 700 shares. Over 100 press stories followed on Brian's announcement; there's too many to show, but IGN, Destructoid, Eurogamer and Rock, Paper, Shotgun are just the tip of the iceberg.
If you want to join the discussion on Bard's Tale, we've opened up official forums here, and you can also follow us on Facebook here.
Wasteland 2 Physical Goods
By now, the vast majority of our physical goods have shipped out, including standard boxes and Collector's Editions. If you have not received your Wasteland 2 boxed copy, please get in touch as soon as possible by emailing email@example.com or using the Ranger Center contact form. We do not yet have a strict cutoff date, but we'd prefer everyone gets their copy sooner rather than later.
Some of our backers were also due Doomsday Kits with their pledges. All of these have now shipped out to our backers in the United States, and we are in the final stages of shipping out to international backers - if that's you, don't worry, we'll contact you by email shortly with more details once we know they've left the building (and are no longer stacked ceiling-high in Matt's office).
We love seeing promising new games on Kickstarter, and we've got some notable ones we'd like to share. Our friends at ArtCraft Entertainment, helmed by Gordon Walton and J. Todd Coleman, has recently launched their Kickstarter for Crowfall, a new type of Massively Multiplayer Online Role Playing Game. It is a unique MMO which focuses on passage of time, destructible environments, and massive player factions, politics, and warfare. It's off to a great start, having funded in its first few days, so be sure to take a look.
Meanwhile, OtherSide Entertainment has been running its campaign for Underworld Ascendant, which promises to be a spiritual follow-up to Ultima Underworld, a game that's near and dear to many folks at inXile. Underworld is spearheaded by Paul Neurath, who some of you might know for his work with Looking Glass Studios, which spans a pretty impressive portfolio: System Shock, Thief, and, of course, Ultima Underworld. They're 99% of the way there as we're posting this, and have 6 days left to hit some very enticing stretch goals. Consider jumping on board!
We'd also like to congratulate our friends at Harebrained Schemes on their highly successful Kickstarter campaign for their next Shadowrun title, Shadowrun: Hong Kong. They were able to raise $1.2 million, and will be bringing a new mini-campaign to the Shadowrun universe. Missed the Kickstarter, they're running a second chance backer campaign until March 13th, check their website for more info.
In Other News
Brian Fargo has done an interview about crowdfunding, working with fans, and Wasteland 2 with Making Games.
After winning PC World's Game of the Year among other end-of-year mentions, we're honored to be nominated for the SXSW Awards as one of the top crowdfunded projects of the year. We're sitting in good company among excellent titles such as The Banner Saga and Divinity: Original Sin, and we're blown away by the game's reception even several months after release.
Finally, we have another gift for all of you: a free subscription for 3 digital issues of RETRO Magazine. RETRO is a Kickstarter-funded magazine written by veteran game journalists that focuses on revisiting some of history's greatest games, and exploring the heritage of modern video games. Check the reward tab on your Ranger Center account to access this offer.
Looking forward to another great year with you all!
Chris Keenan,
Project Lead
Francisco Santiago on
I'd totally give up my unredeemed digital copy for a PS4 one. Actually, I'd even give up the physical copy that I never ended up using because it was outdated on arrival (not complaining at all; it's great the game keeps getting updates!).
tarasis on
Regarding BT IV, I will back it the moment you Kickstart it, assuming you do.
That is great news that you continue to work on Wasteland 2 with improvements and graphical fixes. That is the sort of post release support I like to see, where many companies now just release something, maybe do a patch or two and abandon it despite known bugs (Batman Arkham Origins springs to mind). This sort of support reminds me of the level of support Bioware provided post Neverwinter Nights.
Thank you.
inXile entertainment 3-time creator on
@mwalimu GOG.com use their own version numbering system for their games. If you have any questions as to which is the latest available, you will want to get in touch with their support team.
Jason Moyer on
Bard's Tale IV? You haven't even made Dragon Wars 2 yet. And that was the best RPG that came out of old Interplay.
mwalimu on
Can you explain the version numbers? On Gog the linux version is at 1.9.0 even though I have version 126.96.36.199.10 installed (which I got from Gog in November). The Mac version is at 126.96.36.199 and the Windows version is 126.96.36.199 with patch 6. When can I expect a stand-alone linux version with the latest updates?
Stephen "Stoibs" DSuperbackeron
Interesting news regarding Unity.
Truth be told all I'm waiting for is a balance patch addressing Assault Rifle Burst Mode +Headshot toggle trumping all, along with pistol characters being completely unviable and underpowered comparatively late game. =(
Francisco Santiago on
Wow. As if you haven't given us enough! This has got to be the best project I've backed.
T.J. Brumfield on
I'm assuming that part of the reason Wasteland 2 is getting a Unity 5 bump is because the engine for Torment/Bard's Tale IV isn't that different. So as they are switching to Unity 5 for future projects, they can backport those changes to Wasteland 2.
Jeremie LariviereSuperbackeron
Bard's Tale IV!!!! :-)
Tobi (Crusader Kickstarter pls!!) on
really awesome how much love and work you're still giving to wasteland even after release! oooooh and if you upgrade to unity 5 that surely means you intend to continue working on it until...maybe a new campaign or sequel or so? I would def. be up for that! anyway, thank you for an outstanding campaign and i am looking forward to bard's tale (although I've never played the previous parts).
T.J. Brumfield on
@Jason Devine - Bard's Tale IV will be a sequel to the classic floppy disc Bard's Tale games. They've said you can even import your Bard's Tale III save. It won't be like the parody console Bard's Tale game they made.
Vasilis Foukarakis on
Always nice to see a single player game getting so much support!
I have a very important question to ask you. I've stopped my playthrough after reading about upcoming balance changes in order to continue playing WITH the changes. I've done just a few quests after arriving to LA.
Reading about balance fixes and gameplay mechanic changes is always appreciated but I'm starting to worry about backwards compatibility.
Should I worry? Are all these changes going to affect the game so much that previous save games cannot be used? Because I don't really have the free time to restart the game from scratch and I don't want to be stuck in an 'obsolete' playthrough after the patch hits.
So can we get confirmation that all these changes aren't going to affect ongoing sessions? And if they do affect gameplay, what can be done for those of us who don't really want to restart the game from scratch? I want to finish the story!
Thanks in advance!
Jason Devine on
Wait bards tale as in the Monty Python like action rpg or bards tale the thing I used to play on floppy discs at school?
Interstellar Marine on
You are the best! I love your dedication and continued support of Wasteland 2!
T.J. Brumfield on
inXile gave a shout-out to Crowfall which is Nice. Brian Fargo was the one that started the Kick it Forward initiative and I love how much he has leveraged his success to benefit others.
I'd also like to call out Underworld Ascendant. Crowfall is a PvP-focused MMO, but Underworld is a single player throwback RPG, so I'm thinking it is very much in the wheelhouse of inXile fans.
It is made by the founder or Looking Glass Studios and the lead designer of Underworld 2. They have Warren Spector onboard as an advisor. Tracy Hickman is going to write a novel. Dennis Loubet is going to do cover art.
Underworld was the first 3D textured game of all time. It was very innovative from a technical standpoint, and also in how it created a logical sandbox where players can solve puzzles in a number of ways (like an inXile game) while also presenting a narrative.
The new Underworld has an "Improvisation Engine" to expand upon these sandbox elements allowing for creative solutions to problems, and a changing world that reflects your presence.
This game looks amazing, but it hasn't had much visibility and support.


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WASHINGTON (AP) - The businessman arrived at the Department of the Treasury carrying a suitcase stuffed with about $5.2 million in petrified, nearly unrecognizable bills. He asked to swap it for a cashier's check.
Money like this normally arrives after a bank burns or a vault floods - It doesn't just show up at the visitors' entrance on a Tuesday morning.
But Franz Felhaber's banking habits had stopped making sense to the government long ago.
For years, authorities say, he and his family have popped in and out of U.S. banks, looking to change about $20 million in decaying $100 bills for clean cash, offering ever-changing stories:
? It was an inheritance.
? Somebody dug up a tree, and there it was.
? It was found in a suitcase buried in an alfalfa field.
? A relative found a treasure map.
That buried treasure stands to make someone rich. It could also send someone to jail.
? Felhaber is a customs broker. His company, F.C. Felhaber&Co., navigates the customs bureaucracy in El Paso, Texas, where tens of billions of dollars in Mexican goods enter each year.
Felhaber says that is all he was doing with the adobe-looking bundles of money. He said a Mexican relative, Francisco Javier Ramos Saenz-Pardo, sought his help. Saenz-Pardo worried a foreigner with that much money would attract unwarranted suspicion, Felhaber said.
If discretion were the goal, Felhaber went about it all wrong. Rather than making one exchange at the Treasury, Felhaber allegedly began trying to exchange smaller amounts at El Paso-area banks, raising suspicion every time.
In 2005, authorities say he arranged a $120,000 exchange at the Federal Reserve Bank in El Paso, with the money being wired to an account belonging to his uncle, Jose Carrillo-Valles.
Banks normally refer such requests to the Bureau of Engraving and Printing, an arm of the Treasury. The $120,000 exchange was an exception. Investigators say Felhaber wasn't so lucky elsewhere.
Immigration and Customs Enforcement officials say he unsuccessfully tried to get a Bank of America armored truck dispatched to the Mexican border to retrieve the money. Weeks later, they say he gave a fake name at two banks while inquiring about exchanging millions.
Once, the explanation was that he discovered the money while excavating a tree in Chihuahua, Mexico. Another time, the story was that it had been buried in an alfalfa field, investigators say.
Felhaber denies nearly all of this, including giving a fake name. But he is tough to pin down on details. At times he acknowledges helping exchange a $20 million inheritance. Minutes later, he contradicts himself and says there's nowhere near that much. And he has no idea where the money came from.
Most of the thousands of mutilated money exchanges each year are routine. Natural disasters create lots of inquiries. Children of the Depression have discovered their attic savings shredded by rodents. Greeting cards stuffed with money are accidentally shredded.
But Leonard Olijar, the chief financial officer of the Bureau of Engraving and Printing, said there are warning signs that will trigger investigations.
ICE agents questioned Felhaber in October 2005. According to a government summary of that interview, Felhaber said he believed the money came from a Mexican land deal. It was buried in a coffin, he said, until Saenz-Pardo - who brought him the money in the first place - discovered a treasure map.
He now says he was mistaken in his interviews with investigators.
"They take you to your word like you're supposed to remember every single thing every single time," he said.
? In January 2006, the strategy apparently changed. The Bureau of Engraving and Printing received a package containing about $136,000 from Jose Carrillo-Valles, Felhaber's uncle. A letter explained the money had been stored in a basement for 22 years.
There was no evidence of a crime, just unanswered questions. So the Treasury mailed a check, which Carrillo-Valles deposited. Yet when authorities followed the money, he and his wife denied knowing about it, according to a government affidavit.
And the $120,000 wired to Jose's account a year earlier from the Federal Reserve? The couple said it was an inheritance.
Authorities don't believe that. They traced a wire transfer from Jose's account to someone named Saenz-Pardo, suggesting that Carrillo-Valles was an intermediary who took a cut of the money and sent the rest to Mexico.
Twice, reporters called Carrillo-Valles. First, he said he spoke no English. When a Spanish-speaking reporter called, he said he could not hear her and he hung up.
The case became a criminal investigation in April 2007. ICE agents called the Department of Justice, saying Felhaber had just arrived at the Bureau of Engraving and Printing with $1.2 million.
Finding money is not a crime, but there are rules about its importation. Import documents identified Jose Carrillo-Valles as owning the $1.2 million. Authorities believe that was a lie - a violation carrying up to five years in prison.
But federal prosecutor William Cowden waited, in case Felhaber tried to exchange even more money.
He did.
This April, Felhaber returned with $5.2 million. Investigators found no import documents this time, a smuggling violation that also carries up to five years in prison.
Prosecutors moved in. Felhaber's Treasury visits gave them probable cause to seize a combined $6.4 million. Authorities told a federal magistrate they suspected it was buried drug money.
? Even though Felhaber often says he doesn't know where the money came from, he says it's definitely not drug money.
Prosecutors don't accuse him of involvement with drugs. Court documents leave open the possibility that somebody stumbled across a cache of abandoned drug money in Mexico.
Prosecutors plan to seek forfeiture of the seized $6.4 million, giving Felhaber and his family the opportunity to ask for the money back. If they do, a judge will ask them to sort through the inconsistent stories.
Cowden, the federal prosecutor, doesn't know what to expect. Perhaps there is $14 million still out there, waiting to be exchanged.
Does Felhaber know if there is?
On that, it's hard to get a straight answer.
Copyright 2008 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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Textappeal: The Advantage of Talents
Beijing, August 2010 – "Textappeal: the Advantage of Talents" – Interview to Elliot Polak published on Modern Advertising Magazine.
In China, even people who work in Advertising industry might not know the name of this company. They hosted a seminar in Cannes this year featuring the topic: Digital Across Cultures. When Elliot, the founder and CEO, introduced the company he highlighted a word "transcreation". We can't find a concise and corresponding Chinese word to explain it as the need of this kind of service might only start to grow rapidly in the future due to the late start of Chinese economy and advertising industry.
Actually, majority operation of this company is from global brands or their creative agencies as their creative ideas and communication will unavoidably face difference countries, regions, ethnic groups and cultural backgrounds and their marketing will have to transfer accordingly. As we mentioned previously the example of Coke Cola, this refers to complicated and subtle details like strategy, creative illustration and text etc. Therefore, Elliot doesn't like the idea of describing their work as "translation".
VERTU phone launched a global campaign in 2007. In the unified creative draft for all markets around the world, the model is wearing a slightly wrinkled white casual suit to illustrate the target is high-end frequent travellers. VERTU phone, which plays the main role in the ad, is held in one hand of the model. However, the final version of the campaign had changed white colour to beige, casual suit to formal and even the hand of the model had been trimmed as neat and smooth as possible. The reason behind it is just because Textappeal had provided 3 suggestions on the original creative draft: in china, firstly, a successful man should have wore formal and sleek suit; secondly, white colour is related to Chinese funerals; thirdly, the hair on the model's hand might be considered as masculine charm in western world, while in China a pair of clean and smooth skin hands will be preferred.
Similar cultural differences exist almost in all cross-border communications and advertisements. For example, in one of the print ads of Barclays Wealth, a classic "vintage" car in the European version of the ad had been changed in China to a brand new car which is fashionable and modern. As Chinese, we believe everyone understands this.
We are very curious that facing such a huge number of countries and regions around the world how can Textappeal conduct such a service which seems "there is nothing they don't understand". "Talents are the core. It consists of multilingual project managers in the London headquarters and 1470 partners all round the world covering 151 countries", Elliot said. Not too long after the interview, we found exclusive introduction of their talents' structure and concept on their newly renovated websites.
In the party in Cannes, there is a girl called Masie showed up together with him. She is from China and is one of the London team members. When Masie started to talk about this team, enthusiasm came up naturally: "it is because we all have different backgrounds and from different countries that it's fun to work together. Our over 1000 partners are again from different countries. You can experience the brilliance of the whole world with vivid details through them." Of course, according to Elliot's standard of talent selecting, apart from language and culture this team has to be experts of marketing and advertising as well. In the past 3 years, projects about China have been the major increase of the operation.


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By Trudy Govier
A realistic examine OF ARGUMENT grants the instruments you must comprehend casual good judgment and formulate a very good argument. by way of concentrating on actual global examples and together with useful learn instruments akin to workouts with solutions, a word list of universal fallacies, bankruptcy summaries, and a book-specific on-line application (available with the book), a realistic research OF ARGUMENT, more suitable 7th variation offers you every thing you must grasp the cloth comfortably. to be had with InfoTrac pupil Collections http://gocengage.com/infotrac.
Read Online or Download A Practical Study of Argument (Enhanced 7th Edition) PDF
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Extra info for A Practical Study of Argument (Enhanced 7th Edition)
Example text
Editorial review has deemed that any suppressed content does not materially affect the overall learning experience. Cengage Learning reserves the right to remove additional content at any time if subsequent rights restrictions require it. 18 A Practical Study of Argument 6. "Don't despair. " (E-mail advice to a medical student, cited in the Globe and Mail, May 23, 1995) *7. Due to pride some people find it easier than others do to admit that they are wrong. You can see that this is true. It works this way: their pride is based on a deep conviction of personal worth.
It is put forward as being acceptable and providing rational support for a further claim. NOTES 1. Nils Christie, A Suitable Amount of Crime (Routledge: London and New York), p. 13. 2. Kevin Jardine, "Canadian Oil on Russian Soil," Greenlink, Vol. 3 (1995), no. 1, p. 1. 3. With regard to the distinction between arguments and explanations, two qualifications must be made. The first is that sometimes discourse taken out of context can plausibly be interpreted either as explanation or as argument.
3 Here Lewis is offering an argument. What is the conclusion he is trying to establish? He talks about babies and ducklings and sex and offers these phenomena as evidence that there are creatures on this earth born with desires that can be satisfied. The examples are offered as the basis for a more general claim to the effect that we do not have desires unless they can be satisfied. Lewis goes on from this general claim to consider what it would mean if people had desires that could not be satisfied in this world.


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June 1-5
* Menus subject to change due to weather and delivery.
MONDAY: Cereal, toast, juice choices, choice of milk.
TUESDAY: Eggs, bacon, toast, juice choices, choice of milk.
WEDNESDAY: Cereal, toast, juice choices, choice of milk.
THURSDAY: Biscuits, chicken, juice choices, choice of milk.
FRIDAY: Cereal, toast, juice choices, choice of milk.
MONDAY: Breakfast pizza or cereal, toast and jelly, fruit or juice, variety of milk.
This weekend promises to be a busy one in Cynthiana. The Home and Garden Show is one of the many events that will be drawing guests to the area.
The sixth annual Home and Garden Show will be at a new location this year... The Burley Co-op Marketing Center on U.S. 27 North.
"We're really excited about the location and the opportunities it provides to our vendors," said Trish Jenkins, Cynthiana Democrat and Harrison Shopper advertising manager.
Ashton Edward Allen Durbin
Ashton Edward Allen Durbin was born to Crystal Kelly and Edward Durbin III of Cynthiana on April 29, 2009 at Harrison Memorial Hospital. He weighed 8 lbs. 8 oz.
Maternal grandparents are Bobby Kelly and Debbie Kelly of Cynthiana; maternal great-grandparents are Jean and Frank Fitch and Janie and Jay Craig.
Paternal grandparents are Susan and Edward Durbin Jr. of Cynthiana; paternal great-grandparents are Jean and Ethel Sparks and Ed and Sally Durbin.
FRIDAY, May 29
Harrison County Extension Homemakers Trip. Boggstown Cabaret, Indiana, Friday, May 29. Still taking applications. Mail trip reservations to Paulette Jones, 1925 Upper Curry Rd., Cynthiana, Ky. 41031. For more information call 859-234-4666. Cost is $59.
Story Hour. Friday, May 29 from 4:30-5 p.m. for ages 2-5 in the Feix Community Room at the Cynthiana-Harrison County Public Library. Pre-registration is not needed.
SATURDAY, May 30
"The Hour of Power" Radio Ministry, aired weekly on Saturday mornings on 90.7 FM (The Wind), at 10-11 a.m.
The Rev. Don Fryman will bring a message each week along with special music by various singers across Harrison County and surrounding counties.
Family Vacation Bible School will be held June 12-14 at Ruddles Mills Christian Church. Bring the entire family to the the ancient city of Rome and see what it was like to live in Rome during Bible times.
The Young Eagles program will host its 10th annual free flights event this Saturday at the Cynthiana-Harrison County Airport.
"It's just a lot of fun for us and the kids too," said Bobby Craft, president of the local airport board. "It's a chance for kids to get up in the air and see what it looks like... maybe even spark an interest in flying."
Beginning at 10 a.m., children ages seven to 17 will be given free airplane rides by local pilots.
Craft said 198 kids received airplane rides last year.
The University of the Cumberlands Office of the Vice President for Academic Affairs is pleased to announce that Rachel Ammerman and Beau Sanders from Cynthiana have been named to the dean's list for the spring 2009 semester.
Full-time students who have obtained a cumulative scholastic standing of 3.5 and have no grade of "I" are eligible for the dean's list.
The Harrison County Board of Education released the results of its annual superintendent evaluation this week.
Taken individually by school board members and then compiled, the results rate Harrison County Superintendent Andy Dotson's ability to meet the goals set by the board at the beginning of the school year.
"The board is thrilled with the work Mr. Dotson has done," said Chairman Ed Taylor. "The board is ecstatic with the progress he's made."
To the editor:
The Anness family reunion will be held Sunday, June 7 at Northside Elementary School. A potluck lunch will be served at noon.
All friends and family are invited to attend.
Copyright © 2019
The Cynthiana Democrat is your source for local news, sports, events, and information in Cynthiana, KY and the surrounding area.


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• A.B. Dartmouth College (1998)
• Ph.D. California Institute of Technology (2005)
• NIH Postdoctoral Fellow, Yale University (2005-2008)
• Searle Scholar (2010)
• Sloan Research Fellow (2012)
• NSF CAREER Award (2012)
• Award for Early Excellence in Physical Organic Chemistry (2013)
Protein motion underlies both proper function and disease in biological systems. Many signaling and transport proteins require complex rearrangements for function, and some proteins, such as amyloids, misfold into toxic conformations. Studying these protein motions not only aids our understanding of diverse biological phenomena, it also contributes to an important fundamental problem in biochemistry: understanding how motions propagate from one end of a protein to another. The Petersson laboratory is developing tools to address questions of how dynamic proteins mediate communication and how the cellular environment catalyzes protein misfolding, from detailed in vitro folding studies to modeling protein motion in living cells. These tools include novel chromophores, which we synthesize and incorporate into proteins through unnatural amino acid mutagenesis and synthetic protein ligation.
Inteins as Traceless Purification Tags for Unnatural Amino Acid Proteins
Batjargal, S.; Walters, C. R.; Petersson, E. J.
J. Am. Chem. Soc. 2015, 137, 1734-1737.
Specific Modulation of Protein Activity Through a Bioorthogonal Reaction
Warner, J. B.; Muthusamy, A. K.; Petersson, E. J.
ChemBioChem 2014, 24, 2508-2514.
Thioamide-Based Fluorescent Protease Sensors
Goldberg, J. M.; Chen, X. S.; Meinhardt, N.; Greenbaum, D. C.; Petersson, E. J.
J. Am. Chem. Soc. 2014, 136, 2086-2093.
Efficient Synthesis and In Vivo Incorporation of Acridonylalanine, a Fluorescent Amino Acid for Lifetime and Förster Resonance Energy Transfer/Luminescence Resonance Energy Transfer Studies
Speight, L. C.; Muthusamy, A. K.; Goldberg, J. M.; Warner, J. B.; Wissner, R. F.; Willi, T.; Woodman, B.; Mehl, R. A.; Petersson, E. J.
J. Am. Chem. Soc. 2013, 135, 18806-18814.
Expressed Protein Ligation at Methionine: N-terminal Attachment of Homocysteine, Ligation, and Masking
Tanaka, T.; Wagner, A. M.; Warner, J. B.; Wang, Y. J.; Petersson, E. J.
Angew. Chem. Int. Ed. 2013, 52, 6210-6213.
Labeling Proteins with Fluorophore/Thioamide FRET Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation
Wissner, R. F.; Batjargal, S.; Fadzen, C. M.; Petersson, E. J.
J. Am. Chem. Soc. 2013, 135, 6529-6540.
Thioamide Quenching of Fluorescent Probes Through Photoinduced Electron Transfer: Mechanistic Studies and Applications
Goldberg, J. M.; Batjargal, S.; Chen, B. S.; Petersson, E. J.
J. Am. Chem. Soc. 2013, 135, 18651-18658.
Organic, Supramolecular and Macromolecular Chemistry
Our research group is involved in the elaboration of synthetic methods, strategies and architectural concepts, as well as in the understanding of the fundamental principles that govern the rational design and synthesis of complex molecular, macromolecular, and supramolecular nonbiological systems that exhibit biological functions. Biological systems are employed as models to develop the synthetic architectural motifs and to control their self-assembly and self-organization during the creation of ordered systems. Our research strikes a balance among a diversity of interrelated disciplines, such as organic, bioorganic, macromolecular, and supramolecular synthesis and catalysis, seeking to understand, mimic, and extend Nature's solutions to the design of synthetic functional nanosystems.
Hierarchical folding, supramolecular chirality, nonbiological ionic and electronic channels and nanowires, nanostructured supramolecular membranes, externally regulated drug release mechanisms, enzyme-like catalytic systems, and self-interrupted organic and macromolecular synthesis are examples of new concepts that are under investigation. Central to the capacity of biological molecules to perform critical functions is their ability to form highly organized and stable 3-D structures using a combination of molecular recognition processes. Therefore, the combinatorial libraries of synthetic building blocks required in our strategies consist of combinations of macrocyclic, dendritic, and other primary sequences that are able to fold into well-defined conformations and also contain all the information required to control and self-repair their secondary, tertiary, and quaternary structure at the same level of precision as in biological molecules. To what extent the delicate balance between the structures and functions evolved in Nature during billions of years can be transplanted to synthetic molecules is a fascinating question.
Towards these goals, we also develop new synthetic methods for the formation of carbon-carbon and carbon-heteroatom bonds using metal-catalyzed homo- and cross-coupling, radical, and various ionic and ion-radical reactions. Living and non-statistically self-interrupted polymerization methods are elaborated based on these organic reactions. The design of the internal structure of complex single molecules and the elucidation of the reactivity principles induced by the controlled environment confined within a single molecule or supramolecule are actively pursued. This research involves collaborations with structural and computational chemists and biochemists.
The central theme of the Molander group's research is the development of new synthetic methods and their application to the synthesis of organic molecules. The group's focus is to expand and improve the Suzuki coupling reaction for organoboron compounds. Robust, air- and water-stable potassium organotrifluoroborates (R-BF3K), are employed to carry out couplings under relatively mild conditions using non-toxic components.
The preparation of aryl- and heteroaryl potassium trifluoroborate and trihydroxyborate salts has been modified to take advantage of atom-economical boron sources, such as bis-boronic acid (BBA) and tetrakis(dimethylamino)diboron, which allow low catalyst loading and relatively mild reaction conditions. Reactive boronic acid species are generated, and subsequent coupling reactions with these substrates allow greener access to biaryl products.
Organotrifluoroborates allow installation of functional groups within a molecule in the place of an existing carbon-boron bond. This allows one to prepare or purchase a simple, functionalized organotrifluoroborate and to elaborate the structure, drawing on the reactivity of the boron species. Some of the transformations carried out to date in this way are outlined below, highlighting the ability to install a cyclopropyl, hydroxymethyl, or nitroso functional group using potassium trifluoroborates.
Some methods have been developed for the synthesis of novel reagents containing alkyltrifluoroborates, namely potassium aminomethyl-, hydroxymethyl-, and a-alkoxyalkyltrifluoroborates. The synthesis of these structures is outlined below with their applications in cross coupling illustrated.
Organic and Catalysis Chemistry
The central theme of research in my laboratory is the rational design of new methods and catalysts for use in organic synthesis. As well as using traditional screening and development approaches, we employ several novel computational tools for the discovery and optimization of new reagents and catalysts. These new synthetic methods comprise the key steps in our total synthesis strategies to a variety of important pharmaceutical agents and natural products.
Asymmetric Oxidative C-C Bond Forming Reactions: The development of chiral catalysts for oxidative C-C bond formation is a major focus in our laboratory. In addition to the substantial potential for developing biomimetic synthetic approaches to a variety of natural products, such transformations are appealing in that C-H bonds are directly transformed to C-C bonds with an inexpensive oxidant, molecular oxygen.
To this end, we developed 1,5-diaza-cis-decalin copper complexes, the catalysts of choice for the oxidative asymmetric biaryl coupling of 2-naphthol derivatives. Study of the mechanism has allowed the development of new reaction methods as well as couplings of highly functionalized 2-naphthols. With this ability, we have completed the first asymmetric synthesis of the natural product nigerone. The first total syntheses of the complex natural products cercosporin and hypocrellin have also been accomplished. These structurally novel compounds display promising photodynamic therapy profiles in cancer treatment. Future goals include exploiting the oxidative biaryl coupling method in the synthesis of chiral bisanthraquinone and naphthodianthrone natural products.
Reactions of α-Ketoesters and Derivatives: We have described bifunctional salen-derived catalysts that contain electronically decoupled Lewis acid and Lewis base sites. This electronic decoupling permits generation of optimally active catalysts as both the Lewis acid and Lewis base can be maximized without quenching each other. These catalysts are particularly effective for the very difficult asymmetric alkylation of α-ketoesters and α-iminoesters to yield α-hydroxy and α-amino acid adducts in enantiomerically pure form. Further studies with α-iminoesters have revealed an umpolung addition pathway allowing addition of nucleophiles to imine nitrogens. We have exploited this reactivity pattern to develop a three-component coupling that generates highly functionalized α-amino acid derivatives.
Computer-Aided Design of Chiral Auxiliaries and Catalysts:Diastereo- and enantioselective chemical reactions are essential components for the efficient synthesis of complex chiral targets. We have generated several computational tools to assist researchers in designing and optimizing chiral catalysts including database searching and functionality mapping. In addition, we have developed semi-empirical quantum mechanical quantitative structure selectivity (QSSR) relationships for accurate and precise enantiomeric excess predictions of chiral catalysts. In one example, we correlated the structures of various beta-amino alcohol catalysts to their enantioselectivities in the asymmetric addition of diethylzinc to benzaldehyde. With our method the selectivities of new catalysts were also calculated. Subsequent chemical synthesis and analysis of the new catalysts indicated that the model was very useful and easily distinguished catalysts of low, moderate, and high selectivity.
Organic Chemistry, Natural Products Chemistry, Heterocyclic Chemistry
Investigations carried out in our laboratory encompass a wide range of interests in synthetic organic chemistry including heterocyclic and medicinal chemistry.
Current efforts are in the following areas: (1) synthesis and chemistry of five-membered heterocycles and natural products containing such units; (2) synthesis and chemistry of fungal metabolites; (3) synthesis and chemistry of cyclopeptide alkaloids; (4) synthesis of biologically important depsipeptides; (5) synthesis of novel ninhydrins; (6) synthesis of anti- angiogenic agents.
B. Liang, et al. "Total Syntheses and Biological Investigations of Tamandarins A and B and Tamandarin A Analogs." J. Am. Chem. Soc. 2001, 123, 4469-4474.
D. Xiao et al. "Total Synthesis of a Conformationally Constrained Didemnin B. Analog." J. Org. Chem., 2001, 66, 2734-2742.
D. Ahuja et al. "Inhibition of Protein Synthesis by Didemnin B: How EF-1a Mediates Inhibition of Translocation." Biochemistry, 2000, 39, 4339-4346.
D. Ahuja, et al. "Inhibition of Protein Synthesis by Didemnins: Cell Potency and SAR." J. Med. Chem., 2000, 43, 4212-4218.
B. Liang, M.D. Vera and M.M. Joullié. "Total Synthesis of [(2S)-Hiv2] Didemnin M." J. Org. Chem., 2000, 65, 4762-4765.
B. Liang, P.J. Carroll and M.M. Joullié. "Progress Toward the Total Synthesis of Callipeltin A (1): Asymmetric Synthesis of (3S,4R)-3,4-Dimethylglutamine." Org. Lett. 2000, 2, 4157-4160.
P. Portonovo et al. "First Total Synthesis of a Fluorescent Didemnin," Tetrahedron, 2000, 56, 3687-3690.
B. Cao, D. Xiao, and M.M. Joullié. "Synthesis of Bicyclic Cyclopropylamines by Intramolecular Cyclopropanation of N-Allylamino Acid Dimethylamides." Org. Lett., 1999,1, 1799-1801.
Identification, characterization and optimization of chemical probes of biological systems; Identification of novel agents to treat neurodegenerative diseases such as Alzheimer's Disease; Design of novel chemical libraries to probe biological systems.
"Synthesis and Biological Evaluation of Benzodioxanyl-Piperazine as Potent Serotonin 5HT1A Antagonists: The Discovery of SRA-333," W.E. Childers, M. Abou-Gharbia, M.G. Kelly, T.H. Andree, B.L. Harrison, G. Hornby, D.M. Huryn, L. Potesto, S.J. Rosenzweig-Lipson, J. Schmid, D.L. Smith, S.J. Sukoff, G. Zhang, L.E. Schechter, J. Med. Chem. 2005, 48, 3467-3470.
"Molecular-modeling Based Design, Synthesis and Activity of Substituted Piperidines as Gamma-Secretase Inhibitors," E. Gundersen, K. Fan, K. Haas, D. Huryn, J.S. Jacobsen, A. Kreft, R. Martone, S. Mayer, J. Sonnenberg-Reines, S.-C. Sun, H. Zhou, Bioorg. Med. Chem. Lett. 2005, 15, 1891-1894.
"A Focused Library of Tetrahydropyrimidinones Amides via a Tandem Binginelli-Ugi Multi-Component Process," S. Werner, D.N. Turner, M.S. Lyon, D.M. Huryn, P. Wipf, Syn. Lett. 2006, 14, 2334-2338.
"Screening of 5HT1A Receptor Antagonists Using Molecularly Imprinted Polymers," N.A. O'Connor, D.A. Paisner, D. Huryn, K. J. Shea, J. Am. Chem. Soc. 2007, 129, 1680-1689.
"Paclitaxel C-10 Carbamates: Potential Candidates for the Treatment of Neurodegenerative Tauopathies," C. Ballatore, E. Hyde, R.F. Dieches, V.M.-Y. Lee, J.Q. Trojanowski, D. Huryn, A.B. Smith, Bioorg. Med. Chem. Lett. 2007, 17, 3642-3646.
"Identification and Characterization of a Unique Thiocarbazate Cathepsin L Inhibitor," M.C. Myers, P.S. Shah, S.L. Diamond, D.M. Huryn, A.B. Smith, Bioorg. Med. Chem. Lett. 2008, 18, 214-218.
"Pyrimidinone-Peptoid Hybrid Molecules with Distinct Effects on Molecular Chaperone Function and Cell Proliferation," S.M. Wright, R.J. Chovatiya, N.E. Jameson, D.M. Turner, G. Zhu, S. Werner, D.M. Huryn, J.M. Pipas, B.W. Day, P. Wipf, J.L. Brodsky, Bioorg. Med. Chem. 2008, 16, 3291-3301.
"Design, Synthesis and Evaluation of Inhibitors of Cathepsin L: Exploiting a Unique Thiocarbazate Chemotype," M.C. Myers, P.P. Shah, M.P. Beavers, A.D. Napper, S.L. Diamond, A.B. Smith, D.M. Huryn, Bioorg. Med. Chem. Lett. 2008, 18, 3636-3651.
"Kinetic Characterization and Molecular Docking of a Novel, Potent, and Selective Slow-Binding Inhibitor of Human Cathepsin L," P.P. Shah, M.C. Myers, M.P. Beavers, J.E. Purvis, H. Jing, H.J. Grieser, E.R. Sharlow, A.D. Napper, D.M. Huryn, B.S. Cooperman, A.B. Smith, S.L. Diamond, Mol. Pharm. 2008, 74, 34-41.
"Molecular Docking of Cathepsin L Inhibitors in the Binding Site of Papain," M.P. Beavers, M.C. Myers, P.P. Shah, J.E. Purvis, S.L. Diamond, B.S. Cooperman, D.M. Huryn, A.B. Smith, J. Chem. Inf. Model. 2008, 48, 1464-1472.
"Discovery of a Novel Series of Notch-Sparing γ-Secretase Inhibitors," A. Kreft, B. Harrison, S. Aschmies, D. Atchison, D. Casebier, D. Cole, G. Diamantidis, J. Ellingboe, D. Hauze, Y. Hu, D. Huryn, M. Jin, D. Kubrak, P. Lu, J. Lundquist, C. Mann, R. Martone, W. Moore, A. Oganesian, A. Porte, D.R. Riddel, J. Sonnenberg-Reines, J.R. Stock, S.-C. Sun, E. Wagner, K. Woller, Z. Xu, H. Zhou, J.S. Jacobsen, Bioorg. Med. Chem. Lett. 2008, 18, 4232-4236.
"Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer's Disease," S.C. Mayer, A.F. Kreft, B. Harrison, M. Abou-Gharbia, M. Antane, S. Aschmies, K. Atchison, M. Chlenov, D.C. Cole, T. Comery, G. Diamantidis, J. Ellingboe, K. Fan, R. Galante, C. Gonzales, D.M. Ho, M.E. Hoke, Y. Hu, D. Huryn, U. Jain, M. Jin, K. Kremer, D. Kubrak, M. Lin, P. Lu, R. Magolda, R. Martone, W. Moore, A. Oganesian, M.N. Pangalos, A. Porte, P. Reinhart, L. Resnick, D. R. Riddell, J. Sonnenberg-Reines, J.R. Stock, S.-C. Sun, E. Wagner, T. Wang, K. Woller, Z. Xu, M.M. Zaleska, J. Zeldis, M. Zhang, H. Zhou and J.S. Jacobsen, J. Med. Chem. 2008, 51, 7348–7351.
Organic Chemistry
For many years the Dailey group has been involved in the areas of reactive intermediates, strained-ring chemistry, computational chemistry, matrix isolation, and organo-fluorine chemistry.
More recently we have turned our attention to the study of the mechanism of anesthesia. Many of the currently used inhalation anesthetics are small fluorinated molecules. One of the currently most widely used intravenous anesthetics is Propofol, a drug which allegedly contributed to the demise of Michael Jackson. Anesthetics are some of the most dangerous drugs currently used today, and their mechanism of action (both good and bad) remains largely unknown. New photoaffinity anesthetic compounds which mimic anesthetics but which can be photoactivated so that they can bind to potential molecular targets are being developed in our group. Using these compounds we are investigating the mechanism of anesthesia in collaboration with Dr. Roderick Eckenhoff's group at the School of Medicine at Penn. This collaboration was recently highlighted in C&E News.
Michael A Hall, Jin Xi, Chong Lor, Shuiping Dai, Robert Pearce, William P. Dailey, Roderic G. Eckenhoff , "AziPm, photoactive analog of the intravenous general anesthetic, propofol", J. Med. Chem., 2010, 53, 5667 - 5675.
Jerome Henin, William P. Dailey, Grace Brannigan, Roderic Eckenhoff, Michael L. Klein, "An Atomistic Model for Simulations of the General Anesthetic Isoflurane", J. Phys. Chem. B. 2010, 114(1), 604 - 612.
Roderic G. Eckenhoff, Jin Xi, Motomu Shimaoka, Aditya Bhattacharji, Manuel Covarrubias, William P. Dailey, "Azi-isoflurane, a photolabel analog of the commonly used inhaled general anesthetic, isoflurane", ACS Chemical Neuroscience, 2010, 1, 139 - 145.
L. Sangeetha Vedula, Grace Brannigan, Nicoleta J. Economou, Jin Xi, Michael A. Hall, Renyu Liu, Matthew J. Rossi, William P. Dailey, Kimberly C. Grasty, Michael L. Klein, Roderic G. Eckenhoff, Patrick J. Loll, "A Unitary Anesthetic Binding Site at High Resolution" J. Biol. Chem., 2009, 284, 24176-24184.
Jin Xi, Renyu Liu, Matthew J. Ross, Jay Yang, Patrick J. Loll, William P. Dailey, and Roderic G. Eckenhoff, "Photoactive Analogues of the Haloether Anesthetics Provide High-Resolution Features from Low-Affinity Interactions", ACS Chem. Biol., 2006, 1 , 377-384.
Tomas Martinu and William P. Dailey, "On the Reactivity of 1-Chloro-3-phenyldiazirines", J. Org. Chem., 2006, 71, 5012-5015.
Tomas Martinu and William P. Dailey, "Synthesis of Carboalkoxychloro- and Bromodiazirines", J. Org. Chem., 2004, 69, 7359-7362.
Roderic G. Eckenhoff, Frank Knoll, Eric P. Greenblatt, William P. Dailey " A Photolabel Mimic for the Inhaled Haloalkane Anesthetics", J. Med. Chem., 2002, 45, 1879 - 1886.
Dana R. Reed, Steven R. Kass, Kathleen R. Mondanaro, William P. Dailey "Formation of 1 1-Bicyclo[1.1.1]pentyl Anion and an Experimental Determination of the Acidity and C-H Bond Dissociation Energy of 3-t-Butylbicyclo[1.1.1]pentane", J. Am. Chem. Soc., 2002; 124(11); 2790-2795.
T. Martinu and W.P. Dailey " Facile One-Pot Preparation of 3-Chloro-2-(chloromethyl)propene and an Ab Initio Study of the Deamination Reaction of Nitrosoaziridine", J. Org. Chem. 2000, 65(20); 6784-6786.
T. Hirayama et al. "Responsive-to-Antagonist, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis", Cell 1999, 97, 383-393.
D. L. S. Brahms and W. P. Dailey "Fluorinated Carbenes", Chem. Rev. 1996, 96, 1585-1632.
T. D. Golobish and W. P. Dailey "Synthesis and Structure of Bishomohexaprismanedione", Tetrahedron Lett. 1996, 37, 3239 - 3242.
D. L. S. Yokotsuji et al. "Generation, Direct Observation under Matrix-isolation Conditions and Ab Initio Calculations for 2-Azacyclopenta-2, 4-dien-1-one", J. Phys. Chem. 1995, 99, 15870 - 15873 .
C. A. Jacobs, J. C. Brahms, W. P. Dailey, K. Beran and M. D. Harmony "Synthesis, Microwave Spectrum, and Ab Initio Calculations for Difluorocyclopropenone", J. Am. Chem. Soc. 1992, 114, 115-121.
M. A. Forman and W. P. Dailey "The Lithium Perchlorate-Diethyl Ether Rate Acceleration of the Diels-Alder Reaction: Lewis Acid Catalysis by Lithium Ion", J. Am. Chem. Soc. 1991, 113, 2761-2762.
Organic and Bioorganic Chemistry
Research in the Chenoweth laboratory is grounded in organic chemistry and molecular recognition with applications to biological and materials problems. We synthesize molecules and study their properties and interactions for a broad range of applications in bioorganic and materials chemistry. We are particularly interested in the design and synthesis of new molecules that can modulate nucleic acid and protein structure. Additionally, we are equally interested in the synthesis of new materials with sensing and self-assembly properties.
Undergraduate students, graduate students, and postdoctoral researchers are exposed to a diverse array of topics including organic chemistry, synthesis, bioorganic chemistry, macromolecular structure (nucleic acids and proteins), biochemistry, and polymer chemistry.
Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M. "Aza-Glycine Induces Collagen Hyperstability" J. Am. Chem. Soc. 2015, ASAP. DOI: 10.1021/jacs.5b04590. See Chemical & Engineering News story by Stu Borman: "Chemical Modification Is Best Ever At Strengthening And Stabilizing Collagen" Chemical & Engineering News, Volume 93, Issue 38, p. 7, News of The Week.
Zhang, Yitao; Malamakal, Roy M.; Chenoweth, David M. "A Single Stereodynamic Center Modulates the Rate of Self-Assembly in a Biomolecular System" Angew. Chem. Int. Ed. 2015, 54, 10826-10832.
Suh, Sung-Eun; Barros, Stephanie A.; Chenoweth, David M. "Triple Aryne–Tetrazine Reaction Enabling Rapid Access to a New Class of Polyaromatic Heterocycles" Chemical Science 2015, 6, 5128-5132.
Tran, Mai N.; Chenoweth, David M. "Synthesis and Properties of Lysosome-Specific Photoactivatable Probes for Live-Cell Imaging" Chemical Science 2015, 6, 4508-4512.
Barros, Stephanie A.; Chenoweth, David M. "Triptycene-Based Small Molecules Modulate (CAG)·(CTG) Repeat Junctions" Chemical Science 2015, 6, 4752-4755.
Tran, Mai N.; Chenoweth, David M. "Photoelectrocyclization as an Activation Mechanism for Organelle Specific Live-Cell Imaging Probes" Angew. Chem. Int. Ed. 2015, 54, 6442-6446.
Ballister, Edward R.; Ayloo, Swathi; Chenoweth, David M.; Lampson, Michael A.; Holzbaur, Erika L.F. "Optogenetic Control of Organelle Transport Using a Photocaged Chemical Inducer of Dimerization" Current Biology 2015, 10, R407-R408.
Ballister, Edward R.; Aonbangkhen, Chanat; Mayo, Alyssa M.; Lampson, Michael A.; Chenoweth, David M. "Localized Light-Induced Protein Dimerization in Living Cells using a Photocaged Dimerizer" Nature Communications 2014, 5, 5475.
Barros, Stephanie A.; Chenoweth, David M. "Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules" Angew. Chem. Int. Ed. 2014, 53, 13746-13750.
Rarig, Robert-André F.; Tran, Mai N.; Chenoweth, David M. "Synthesis and Conformational Dynamics of the Reported Structure of Xylopyridine A" J. Am. Chem. Soc. 2013, 135, 9213–9219, ASAP.
Chenoweth, David M.; Meier, Jordan L.; Dervan, Peter B. "Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA" Angew. Chem. Int. Ed. 2013, 52, 415-418.
Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M. "DNA−CNT Nanowire Networks for DNA Detection" J. Am. Chem. Soc. 2011, 133, 3238–3241.
Chenoweth, David M.; Dervan, Peter B. "Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding" J. Am. Chem. Soc. 2010, 132, 14521. Selected for the cover of JACS Oct. 20, 2010, Vol 132, Issue 41. Covered by Chemical and Engineering News Sept. 27, 2010 issue, "Putting DNA in a Bind".
Weizmann, Yossi; Chenoweth, David M.; Swager, Timothy, M. "Addressable Terminally-Linked DNA-CNT Nanowires" J. Am. Chem. Soc. 2010, 132, 14009.
Weizmann, Yossi; Lim, Jeewoo; Chenoweth, David M.; Swager, Timothy, M. "Regiospecific Synthesis of Au-Nanorod/SWCNT/Au-Nanorod Heterojunctions" Nano Lett. 2010, 10, 2466.
Chenoweth, Kimberly; Chenoweth, David M.; Goddard III, William A. "Cyclooctyne-based Reagents for Uncatalyzed Click Chemistry: A Computational Survey" Org. Biomol. Chem. 2009, 7, 5255.
Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. "Oligomerization Route to DNA Binding Py-Im Polyamide Macrocycles" Org. Lett. 2009, 11, 3590.
Chenoweth, David M.; Dervan, Peter B. "Allosteric Modulation of DNA by Small Molecules" Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 13175. Covered by Nature News: "Get into the groove" Nature 2009, 460, 669. Also selected by the Stanford Synchrotron (SSRL) as a science highlight for November 2009.
Chenoweth, David M.; Harki, Daniel A.; Dervan, Peter B. "Solution-Phase Synthesis of Pyrrole-Imidazole Polyamides" J. Am. Chem. Soc. 2009, 131, 7175.
Chenoweth, David M.; Harki, Daniel A.; Phillips, John W.; Dose, Christian; Dervan, Peter B. "Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element" J. Am. Chem. Soc. 2009, 131, 7182.
Chenoweth, David M.; Chenoweth, Kimberly; Goddard III, William A. "Lancifodilactone G: Insights about an Unusually Stable Enol" J. Org. Chem., 2008, 73, 6853.
Dose, Christian; Farkas, Michelle E.; Chenoweth, David M.; Dervan, Peter B. "Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit" J. Am. Chem. Soc., 2008, 130, 6859.
Chenoweth, David M.; Viger, Anne; Dervan, Peter B. "Fluorescent Sequence-Specific dsDNA Binding Oligomers" J. Am. Chem. Soc., 2007, 129, 2216. Covered by Chemical and Engineering News.
Chenoweth, David M.; Poposki, Julie A.; Marques, Michael A.; Dervan, Peter B. "Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-k B binding inhibition" Bioorg. Med. Chem., 2007, 15, 759.
Doss, Raymond M.; Marques, Michael M.; Foister, Shane; Chenoweth, David M.; Dervan, Peter B. "Programmable Oligomers for Minor Groove DNA Recognition" J. Am. Chem. Soc., 2006, 128, 9074.
Nurok, D.; Frost, M. C.; Chenoweth, D. M. "Separation using planar chromatography with electroosmotic flow" J. Chromatogr., A, 2000, 903, 211.
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