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Moves to mitigate the threat posed by cabbage stem flea beetle following the ban on neonicotinoid seed treatments could have knock-on effects on other areas of oilseed rape crop management.
An OSR 'state of the nation' survey of 300 growers and 50 agronomists conducted by BASF last autumn revealed 55% of respondents had increased seed rates and 42% had drilled early in a bid to mitigate the risk of cabbage stem flea beetle (CSFB) damage.
One consequence of this approach is that crop canopies can be large coming out of winter, which may not be good news for yield.
BASF business development manager Clare Tucker says: "Although forward crops are more comforting to see than backward one, they will require canopy management by reducing early nitrogen and by using PGRs."
With the aim to maximise seed set by achieving the optimum canopy size – a green area index (GAI) of 3.5 at flowering – the need for PGR treatment can be assessed by measuring the GAI of a crop just before stem extension – typically in late February.
There are a number of approaches available, including using an app such as the BASF GAI Tool, crop fresh weight calculations or using a fraction of soil covered by crop approach.
The economic threshold for an application of a specialist OSR plant growth regulator (PGR) such as Caryx (mepiquat + metconazole) is a GAI of 0.8.
ADAS head of crop physiology Pete Berry says: "We recommend you assess the crop canopy before the stem starts extending. You don't need a massive crop to respond positively to a PGR."
How to estimate green area index (GAI)
Source: ADAS
Canopy management in OSR – key messages
Source: ADAS
Managing smaller canopies
Oilseed rape crops held in check into early spring by cold conditions will be poised for rapid growth as soon as things warm up. But if the main raceme then shoots away, the yield potential of lower branches could be significantly reduced, advises Syngenta field technical manager James Southgate.
However, well-timed PGR applications can beneficially hold back stem extension and enable the side shoots to develop simultaneously – establishing a stronger structure and leaf canopy to produce higher yields, he says.
More advanced crops can be expected to lose leaves in cold conditions but with well-established root structures they are well placed to recover quickly. An early Toprex (difenoconazole and paclobutrazol) application, from early stem extension (GS31) will encourage branching and even up the crop, says Mr Southgate.
Smaller crops, with limited root reserves, however, will need nurturing to increase their green area, when they may then benefit from a later PGR application, from GS51, to develop shape and branching which will make the most of potential light interception.
"With a genuine PGR you can shape the crop to improve its overall efficiency. So while the onset of flowering on the main raceme may be later, you then get all the side shoots flowering at a similar time – so the flowering is far more intense, but over a shorter period."
The benefit for the crop is that the yellow flowers physically reflect sunlight, so a shorter duration of flowering means that green leaves are able to absorb and utilise more energy.
However, where small crops continue to be slow to get going into spring, or suffer severe pigeon damage, they may be better left without PGR treatment, says Mr Southgate.


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Over time, our skin experiences various changes, and most often they are the consequence of our way of living. For example, if you have bad eating habits and are exposed to the sun too often, skin spots are more likely to appear. However, even if you're a health freak and hide from the sunrays, mere ageing can lead to the same outcome. Therefore, we've decided to share some useful advice on how to treat these stubborn spots and help your skin stay young and fresh as long as possible.
Cleanse your skin with a special brush
A special powered cleansing brush is your best ally in fighting against skin spots and depigmentation. Owing to it, you'll be able to get rid of all dead skin cells allowing your skin to breathe and letting it absorb the spot treatment much more efficiently. Finally, keep in mind to repeat this process every two days if you want to see quick results.
Go all natural
Luckily, there are so many natural ingredients that can help you combat this annoying skin condition, and lemon juice is definitely our favourite one. However, since it can be quite strong and thus irritate your skin, you should mix it with other skin lightening ingredients like honey. Once you have your mixture ready, apply it onto the spots and leave it for about 15 minutes. In the end, rinse it off and enjoy the results.
Make good use of advanced technology
Nowadays, technology is advancing quite quickly, so we can encounter more and more super high-tech gadgets in the cosmetics field as well. For example, the amazing laser skin care has gained quite a lot on popularity recently, due to the non-invasive characteristics of this treatment and its quick results as well. The length of your treatment will depend on the size and colour of your skin spots, but we're sure that the outcome will pleasantly surprise you and you'll know that it was worth it.
Try out chemical peels
Another effective treatment against skin spots is a chemical peel. Firstly, the chemicals are applied to your skin leading to it peeling off and activating the regeneration of skin cells. Finally, the new layer of healthy skin forms. Although this may seem quite painful to you, it's actually quite a routine procedure and the chemicals used (glycolic, lactic and trichloroacetic acid) are safe and can't cause any serious issues aside from slight skin irritation.
Give turmeric a try
Another natural ingredient that will help you get rid of skin spots is a spice called turmeric. Aside from being super healthy and having anti-inflammatory properties, turmeric is extremely effective in getting rid of skin spots and keeping your skin well-nourished. Finally, you can prepare a homemade turmeric lotion so that you can apply this substance easily on your skin. All you need to do is mix the powdered turmeric with honey and cover the spots with it. And, since this mixture is absolutely natural and harmless, you can use it every day and thus accelerate the cleansing process.
Use creams with SPF
Aside from treating the already existing skin spots, you have to make sure to prevent their reappearance as well. And, since the Sun is the number one enemy of your skin, you have to make sure to apply sunscreen regularly before going out. This is also important during the winter months since even though you don't feel the sunrays burning your skin, they can still cause serious damage and even lead to premature ageing.
Invest in high-quality cosmetic products
Finally, if you want your skin to look its best, you should pamper yourself and go for high-quality cosmetics only. Although you'll pay a few extra pennies, you'll know that it was worth it once the results become apparent. For example, you should keep an eye out for products containing vitamin E oil since this ingredient has been shown to be a great antioxidant which targets free radicals effectively and thus slows down the ageing process, as well as skin decolouration and the reappearance of spots.
As you can see, dealing with skin spots is not that hard after all. You just need to be patient and try to find the most suitable treatment that won't cause any irritation to your skin and which will have excellent results. Finally, keep in mind that all of this requires some time, so don't give up too easily.

subset: commoncrawl


text:
8360 8360B B series 8360L 8360 L Series Quick Reference Guide. #08360-90126
Please note that this is an original manufacturers copy, not a photocopy. No reserve.
One of your best warranties is knowing whom you're doing business with. Please click on the "ME" icon for more information.
(this posting is the responsibility of the poster)
email@example.com (Paige Solomon) for more information. All emails will be forwarded to the poster's actual email address.


text:
Zyra's website //// Linux //// site index //// Link back to LINUX page here
This page was an advertisement for...
...who kindly consented to include us in their affiliate scheme. This meant that if you visited Linux 2 Order from this site, I'd get paid commission. However, it appears now, unfortunately, that the links no longer work. In fact the address www.linux2order.com no longer exists (2001/12). Surely they've not gone broke? If so, that's a pity, but there are a great many other Linux companies. Have a look. Some of them are paying me commission, and some not. But I'm still linking to them because Linux is to be encouraged!
Here was the old link for Linux2order (gone)
www.linux2order.com affiliate program WAS via Commission Junction but is now long ago bunged up. However, Linux keeps on going on!


text: LIke the title says, I'm buying a new laptop, and after a crappy experience with my HP laptop, I'm going to switch over to a Macbook. My only problem is I'm not a computer geek, so I have no clue what I'm doing. True computer geeks won't be offended by the title, I don't think. It's not meant to offend. I'm hoping someone can give me some pointers. Here are the details: I'm starting back to college to get my masters. I will use the laptop for frequent internet access. I will NOT be playing computer games on it, with the exception of maybe an online scrabble game with my sister, or somthing... Nothing too intense. I frequently take and upload pics to photobucket. I frequently download the same pics to my computer. I don't want to overkill, and get way more computer than I need, but at the same time, I don't want to go too low, and be disappointed. Can someone take my needs list, and translate that to English for me. Thanks in advance. Jason


text:
University Leadership
Undergraduate Admission
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Contact Us
Your unique leadership journey starts at Simmons. You'll define what success means to you, and we'll help you get there.
At Simmons, leaders make themselves. You won't sit back and wait for eureka moments. You won't hope for explicit instructions to land in your lap. Rather, you'll work, discover and evolve.
Accessible and accountable, our administration leads by example. And we hold firm to one purpose: to work for you.
At Simmons, you'll roll up your sleeves and contribute to a unique community of curious, compassionate and ambitious people. Your future starts here.
Whether you're coming straight from undergraduate study or making a change mid-career, our programs will help you make your next move.
Our schools and departments offer specialized resources to support and challenge you. Find yours.
Ready to make your move? Apply now.
Discovering your life's work is a journey. Preparing for it starts at Simmons. Take the first step.
Explore your scholarship and financial aid options.
On the field, in the pool or in the stands -- find the best way to show your Shark Pride!
Find and do what moves you. With over 80 student groups, a campus art gallery, varsity sports, performances and events, there's something happening on campus every day!
You'll find everything you need on campus — from medical resources to keep you healthy to technical support to keep your computer running.
Strengthen your relationship with Simmons today.
Rekindle friendships. Make new business contacts. Connect with kindred spirits.
You can have a transformative impact on our world, starting at Simmons.
NewsSchool of Library and Information Science2014MayMay SLIS Community News
May 31, 2014
GSLIS Adjunct Professors Susan Ballard and Deborah Lang Froggatt were among 50 invited scholars participating in a national IMLS-sponsored research summit. Focused on setting an agenda for future school library research the "Causality: School Libraries and Student Success (CLASS)" summit took place April 11-12, 2014 in Chicago and was "an opportunity for school library and educational researchers to look critically at the relationship between school library programs and positive contributions to student achievement." http://www.ala.org/news/press-releases/2014/04/national-imls-research-summit-focuses-school-librarians-and-student.
Associate Dean and Professor Jeannette Bastian had two chapters published in recent titles: "Ethics for Archivists and Records Managers," in Archives and Recordkeeping; Theory into Practice ed. C. Brown (London: Facet Publishing, 2014) and "Documenting Community Through the Lens of Collective Memory," in Identity Palimpsests, Archiving Ethnicity in the U. S. and Canada, ed. D. Daniel and A. Levi (Sacramento: Litwin Books, 2014). Bastian presented "The Community In Place: Archives, Memory, Landscape," at a conference on Memories, Identities and Communities at the Centre for Archive and Information Studies, University of Dundee, Scotland, April 24. 2014.
Associate Dean and Professor Jeannette Bastian and Associate Professor of Practice Donna Webber participated in the New England Archivists session, "Sharing Stories: The New England Archivists/StoryCorps Project" at the March meeting. Bastian and Webber were both interviewed by StoryCorps last fall as part of the NEA 40th anniversary celebration.
Assistant Professor Joel Blanco-Rivera and Assistant Professor Laura Saunders presented the symposium "The Right to Know: Information Access & Information Literacy in the Professions" at Simmons on March 31. The keynote speakers were Paul Sturges, Professor Emeritus, Loughborough University, UK and Almuth Gastinger, Senior Research Librarian, Norwegian University of Science & Technology. Saunders and Blanco-Rivera participated in a panel discussion with SSW Professor of Practice Gary Bailey, SHS Professor of Practice Rebecca Koeniger-Donohue, SOM Dean/Associate Professor John Lowe, and CAS Associate Professor Catherine Paden. The event was funded through a Simmons College PDIAC/SimmonsPalooza grant, and is co-sponsored by the American Library Association Student Chapter (ALA/SC) and the Progressive Librarians Guild (PLG).
GSLIS Master's student Anna Bognolo participated in a poster session at the ACRL New England Annual Conference at Holy Cross in Worcester Mass. on May 9, 2014. Other posters were presented by Abigail Baines '10LS, Anthony Penny '11LS, Gary Atwood '05LS, and Cassandra Watt '12LS.
GSLIS student Cathy Collins, School Librarian at Sharon (MA) High School, has been named this year's recipient of the AASL Intellectual Freedom Award. Collins is currently enrolled in the Simmons GSLIS Instructional Technology Licensure program.
Computers science and informatics undergraduates Sarah Elmore and Priyal Goyal were inducted into the Order of the Computing Professional. They received certificates of honor at the Senior Banquet on April 24, 2014. The students will graduate from Simmons College on May 9, 2014.
Assistant Professors Lisa Hussey, Mary Wilkins Jordan, Monica Colon-Aguirre, and Laura Saunders presented a panel presentation for ACRL/NEC at Holy Cross in Worcester on May 9, titled "Leveraging Every Opportunity: Using Peer-to-Peer, Classroom Assessment, and Self-Reflection to Improve Teaching."
Assistant Dean Em Claire Knowles was elected to the Freedom to Read Foundation Board of Trustees. This is a two-year term, starting this year.
Boston Public Library's Librarian Laura Koenig '07LS and Associate Professor Amy Pattee were interviewed for the article "Parents in Young-adult Fiction Finally Come of Age," in the Boston Sunday Globe, May 11, 2014.
Dean and Professor Emeritus James Matarazzo and Dr. Toby Pearlstein '87DA presented a Simmons College GSLIS Webinar entitled, "Ebooks in Corporate Special Libraries". On April 29, 2014, the Drs. Matarazzo and Pearlstein are presenting a program at the Annual Conference of the Association of Population Librarians, "Demonstrating the Value of the Corporate Library" in Boston. Pearlstein and Matarazzo published an article, "Special Libraries: A Confluence of Forces Pressing on their Future," in the Journal of Library and Information Sciences, April 28, 2014. Their article, "Salaries of Special Librarians," will appear on the IFLA JOURNAL, V. 40 , July 2014.
An interview with Cathryn Mercier, Director for the Center for the Study of Children's Literature and Professor of English, was featured in the May 2014 issue of "ALSC Voices and Faces" on the website of the Association for Library Service to Children.
GSLIS Master's student Regina Pagani was awarded the NEASIS&T Student Travel Award. A student in the archives program, Pagani's upcoming archival work in Cameroon, Africa is a perfect complement to the theme of this year's ASIST Annual Meeting, "Connecting Collections, Cultures, and Communities." She will receive up to $750 to help defray the costs of attendance at the 2014 ASIS&T Annual Meeting which takes place October 31-November 4 in Seattle, Washington http://www.asis.org/asist2014/.
Assistant Professor Laura Saunders gave a presentation titled "Faculty Perspectives on Information Literacy: What They Want and What We Can Do about It" at NERCOMP in Providence RI, March 25.
Master's student Tim Silva is the recipient of the SLA New England Student Travel Stipend Award. Silva will travel to Vancouver, BC in June to attend the Conference, and will volunteer at the registration table on Sunday, June 8.
Associate Professor of Practice Donna Webber, with Jennifer Pelose '01LS and Abigail Cramer '12LS, gave a webinar on April 24 to the Council of State Archivists entitled "Creating Successful Internships."


text:
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text:
Hey guys, today is the start of a new series here at Triple A. Over the next couple of weeks, I'll be going in-depth on different styles of learning and studying so that you can experiment and find out which way works best for you. By doing this, you'll be able to maximise your final ATAR and any specific subject marks!!
So without further ado, I present, Studying Style #1 Visual Learning
Visual learning is a very effective study style for those who don't like reading things. Unfortunately, whilst it is a fairly well-known style, many people don't actually incorporate it into their studying routine.
So how do you actually study/learn visually?
Basically, you'll be representing your information in the form of graphs, flowcharts, mind maps and diagrams. A picture says 1000 words, and so you should be able to comprise a lot of information into a simple diagram or mind map.
A quick example of this can be done with topic 2 in the HSC economics course:
As you can see here, the topic is broken down into many different sections and arms, allowing you to quickly glimpse at mind map and ingest the information at hand. This is incredibly important when you're cramming through a large paragraph of text, it is incredibly inefficient to read each and every word of it to fully absorb the information. However, with a mind map, all the information is summarised and categorised allowing you to simply follow the links to the section that you want to read.
Moreover, adding diagrams and other visual aids to your studying makes it an interesting experience. A great block of blue/black text looks very drab and unengaging, but the moment you include a colourful mind map or colourful elements to the page, it becomes a lot more appealing to look at.
So what to next?
Grab the last page of your notes or class work and try to create a mind map of it. Break it down into separate categories and use them to segment the information. Bonus points for colour coding each category!


text:
Unmistakably a DC shoe through and through, the Court Graffik SE White and Black Skate Shoes embody classic DC styling. Featured with a durable synthetic leather upper, heavily padded tongue and collar, and an all around cupsole construction for impact support along with skate performance.
Court Graffik SE White and Black Skate Shoes by DC.
Size and Fit:
Shoes run true to size.
Low-profile design.
Product Details:
Durable synthetic leather upper with double stitching throughout.
Heavily padded collar and tongue.
Breathable mesh lined interior.
Cushioned footbed for comfort.
Cupsole construction for impact support.
DC Pill Pattern tread for grip.
DC logo detailing throughout.


text:
Contact Us Directions
Providing funeral services designed to meet the needs of each family.
Coping with Grief
We would like to offer our sincere support to anyone coping with grief. Enter your email below for our complimentary daily grief messages. Messages run for up to one year and you can stop at any time. Your email will not be used for any other purpose.
Saturday December 15, 2018 , 2:00 PM - 4:00 PM at Ralph Meyer & Deters Funeral Home
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Our support in your time of need does not end after the funeral services. Enter your email below to receive a grief support message from us each day for a year. You can unsubscribe at any time.


text:
After a spectacular showcase during E3 2015, Naughty Dog cut short their demo of Uncharted 4 to the public on a cliff hangar. Those with media access, however, managed to see the entire 15 minute demo behind-closed-doors, and now it's available in its entirety for everyone to drool over.
Seriously, it looks almost TOO GOOD.
Uncharted 4 releases exclusively for PlayStation 4 in 2016.


text:
Currently reading
Near + Far
Cat Rambo
Amigurumi Knits: Patterns for 20 Cute Mini Knits
Hansi Singh
Metro 2033
Dmitry Glukhovsky
Southern Gods
John Hornor Jacobs
Masterpieces of Terror and the Supernatural
Robert Louis Stevenson, Orson Scott Card, Jack London, Tanith Lee, Walt Whitman, Guy de Maupassant, Isaac Asimov, Ivan Turgenev, Johann Ludwig Tieck, Marvin Kaye, John Dickson Carr, Bram Stoker, Tennessee Williams, Nathaniel Hawthorne, Richard Matheson, Johann Wolfgang
Howdunit Forensics
Denise Mina
The Autopsy and Other Tales
Michael Shea, Laird Barron
Alice Hearts Welsh Zombies
Victoria Dunn
Blood & Water
Hayden Trenholm, Camille Alexa, Claude Lalumière, Derryl Murphy, M.L.D. Curelas, Kevin Cockle, Douglas Smith, Jean-Louis Trudel, Julie E. Czerneda
Recently added
7:00 pm 22 December 2012
(Dammit, I didn't make a note of when I started reading this. Probably within the month.)
A solid collection with one weak point and a few very good ones. There was a distinct
unity of style and format (teleplays and scripts) that was actually rather appealing.
The Bradbury story that opened the collection struck me as the weakest of the bunch, and it's pretty hard for me to say that; I love Bradbury. It felt almost absurd, and not much else. Contrast the script/vignette by the Mathesons, "Madri-Gall", which felt absurd in much the same way but that I also found deeply funny.
The other scripts were solid, but I found them less engaging. Nolan's (nearly-)autobiographical piece and Robinson's essay weren't what I'd call horror stories, but I was glad to read them, and glad they were included.
Smith's "Love and Magick" was interesting; while the style initially seemed almost a parody, it settled into itself, and I was getting faint echoes of Piccirilli's Necromancer and Self stories. Smith said he was trying to write a horror story that wasn't simply a morality tale, and I think he managed to avoid both that and the "bad things happen because bad things happen" trope very well.
On particularly good notes, I found Tem's story "Red Light" to be the most affecting of the bunch; it did a beautiful job of painting a protagonist that I didn't particularly like, felt sympathy for despite some of the things that came up, and was horrified for, and with, at the end. The anthology also has Goodfellow's "At the Riding School", which I was glad to see again; it got picked up for [b:The Best Horror of the Year Volume 3|11060998|The Best Horror of the Year Volume 3|Ellen Datlow|http://d.gr-assets.com/books/1347985372s/11060998.jpg|15982250] and it's a smart, dark, upsetting, sad piece. I was glad to see it again.
(Also: One of the stories made me want to throw the book at the wall, and I don't treat books that way. I wasn't particularly familiar with the writer's work, and while their writing was enjoyable besides that, I won't be going looking for more.)
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text:
Ode to a blogger
Brits pressed for press freedom in the 18th century, and perhaps no one pressed harder against the forces that opposed him than the rake and wit John Wilkes. Today, there appears to be no opposition to freedom in the press in Britain, but with a few brilliant exceptions, such as Christopher Booker and Janet Daley, the press seems curiously languid about pressing for stories unless they concern celebrities.
Richard North at the blog EU Referendum has written in corrosive detail about an outrageous story: the miserable equipment supporting, correction failing to support, British troops fighting in the field. While the press sleeps, North posts, and sounds the alarum.
A democracy whose free press refuses to publish reports about life and death issues, is preoccupied with movie stars, and is incapable of recognizing propaganda reports and photoshopped images is in considerable danger. Fortunately a Brit's invention of the World Wide Web and the startling forays of bloggers have created new opportunities for readers who like their reporters awake, and smelling the coffee.


text:
Distance education company identitymedical and pharmaceutical education
Vivanti corporate identity design (based on existing logo). A distance training company providing remote continuous medical and pharmaceutical business education.
Design Services
- Stationery design:
business card, letterhead, corporate folder, envelope, etc.;
- Corporate newsletter;
- Presentation design;
- Packaging;
- Souvenirs;
- Brand guidelines creation.
- Stationery design:


text:
Arouse® Love Drops
For All Types Of Hair
Use on fine damaged hair to detangle, condition, and shine.
Use on dull limp hair to add shine and volume. Use on dull, frizzy, coarse
hair to shine, de-frizz and smooth.
Love Drops is very concentrated and will last
for months. Only one spritz is required for short to medium hair and two
spritzes for long hair.
Directions: Spray 1 spritz on palm of hand and rub palms together. Wipe palms on ends of hair and massage throughout. Use 2-3 Spritzes on longer thicker hair. Additional spritzes may be used on the thickest coarsest hair.
Mix a cocktail of Love Drops with other styling products while on palms of your hands, in a recipe formulated for your individual hair. This cocktail will be guaranteed to make your hair look and hold better than anything you have ever used. Just email the Hair Repair Team at firstname.lastname@example.com . Tell them you want your personal recipe and they will formulate it for you and reply to you as if you were their client in their chair.
Never tested on animals


text:
Georgia Trading Post, Inc.3028 Adriatic CtNorcross, GA 30071United Statesph: 770.807.7931fax: email@example.com
We offer high quality custom transfers and garments decorated with Rhinestones, Rhinestuds and Nailhead Crystals. All of our products are guaranteed. Rhinestone, Rhinestuds and Nailhead decorated products are great for corporate events, bridal parties, schools, sports and events of any kind. Please contact us for more information about the stylish and fun product.
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Call us for the quote.
Copyright 2017 Georgia Trading Post, Inc. All rights reserved.
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text:
LEUVEN, Belgium, Aug. 7, 2015 (GLOBE NEWSWIRE) -- TiGenix NV (Euronext Brussels: TIG), an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platform of allogeneic stem cells, announced today that it has reached an agreement with the U.S. Food and Drug Administration (FDA) on a Special Protocol Assessment (SPA) for its Phase III registration trial of Cx601 in the U.S. for the treatment of complex perianal fistulas in Crohn's disease patients.
"We are very pleased with the FDA`s agreement on our clinical design and planned analysis as it represents a clearly defined development and regulatory pathway for approval of Cx601 in the U.S.," said Dr Maria Pascual, VP Regulatory Affairs & Corporate Quality of TiGenix. "Cx601 constitutes a novel mechanism of action to treat perianal fistulas, for which there is still no cure. In the U.S. alone, every year more than 50,000 new patients are waiting for an effective treatment for this debilitating disease."
The agreed pivotal trial is a randomised, double-blind, parallel group, placebo-controlled and multicentre study in complex perianal fistulas in Crohn's disease patients. The study will enroll approximately 224 patients to assess the efficacy and safety of Cx601 24 and 52 weeks after a single dose administration of the product. The SPA describes the primary endpoint as combined remission, defined as clinical assessment by week 24 of closure of all treated external openings draining at baseline despite gentle compression, and absence of collections > 2cm confirmed by MRI. This primary endpoint is in line with the one for the European Phase III trial, which results are expected later this quarter. The company expects to complete the process of manufacturing technology transfer to its U.S.-based CMO, Lonza, and thereafter will start its Phase III trial of Cx601 in the U.S. in the second half of 2016.
For further information:
Ana Pombo Rose
Strategic Planning and IR Manager
Tel: + 34 91 804 92 64
About Special Protocol Assessments
A Special Protocol Assessment (SPA) is a written agreement between a sponsor and the U.S. FDA on the trial design, execution and analysis needed to support FDA product approval. It is intended to form the basis for the marketing application. For more information on SPA, please visit http://1.usa.gov/1w2ODoJ
About Cx601
Cx601 is a suspension of allogeneic expanded adipose-derived stem cells (eASCs) delivered locally through intra-lesional injection. Cx601 is being developed for the treatment of perianal fistulas in Crohn's disease patients. Crohn's disease is a chronic inflammatory disease of the intestine and patients can suffer from complex perianal fistulas for which there is currently no effective treatment. In 2009, the European Commission granted Cx601 orphan designation for the treatment of anal fistulas, recognising the debilitating nature of the disease and the lack of treatment options. In a Phase II clinical trial, Cx601 showed efficacy at 24 weeks in 56% of treated fistula tracts, which is more than two times higher than the current standard of care (TNF inhibitors). Efficacy was measured as the complete closure and re-epithelisation of the fistula being treated with an absence of drainage. Additionally, 69.2% of patients demonstrated a reduction in the number of initially draining tracts. The trial also confirmed the safety of the use of allogeneic stem cells for the treatment of perianal fistula. Based on these results, TiGenix sought scientific advice from the European Medicines Agency (EMA) on the future development path of Cx601. TiGenix then initiated a randomised, double-blind, placebo-controlled Phase III trial in Europe and Israel designed to comply with the requirements laid down by the EMA. 'Madrid Network', an organisation within the Autonomous Region of Madrid which helps companies to grow through high-technology innovation, issued a soft loan to help finance this Phase III study. The programme is funded by The Secretary of State for Research, Development and Innovation (Ministry of Economy and Competitiveness) within the framework of the INNTEGRA plan. This pivotal study is intended to enable filing for marketing authorisation in Europe and to serve as a key supportive study in filing for approval in other territories, including the US. The study's primary endpoint is combined remission, defined as clinical assessment by week 24 of closure of all treated external openings draining at baseline despite gentle finger compression, and absence of collections >2cm confirmed by MRI. The trial has a first complete analysis of results at 24 weeks, with a follow-up analysis to be performed at 52 weeks post-treatment. Recruitment of the whole sample of patients was completed in the fourth quarter of 2014. The first clinical report is expected to be available in the third quarter of 2015. With positive results, TiGenix intends to submit a request for marketing authorisation with the EMA early in 2016. TiGenix is preparing to develop Cx601 for the US market.
About TiGenix
TiGenix NV (Euronext Brussels: TIG) is an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platform of allogeneic, or donor-derived, expanded stem cells. Two products from the adipose-derived technology platform are currently in clinical development. Cx601 is in Phase III for the treatment of complex perianal fistulas in Crohn's disease patients. Cx611 is in Phase II for early rheumatoid arthritis, and has completed a Phase I sepsis challenge trial. Effective as of July 31, 2015, TiGenix acquired Coretherapix, whose lead cellular product (AlloCSC-01) is currently in a Phase II clinical trial in acute myocardial infarction (AMI). Coretherapix is planning to initiate the clinical evaluation of AlloCSC-01 in the chronic setting as well and is also involved in the pre-clinical development of a pharmaceutical formulation of growth factors to treat AMI. Finally, TiGenix also developed ChondroCelect, an autologous cell therapy product for cartilage repair of the knee, which was the first Advanced Therapy Medicinal Product (ATMP) to be approved by the European Medicines Agency (EMA). From June 2014, the marketing and distribution rights of ChondroCelect have been exclusively licensed to Sobi for the European Union (except for Finland, where it is distributed by the Finnish Red Cross Blood Service), Norway, Russia, Switzerland and Turkey, and the countries of the Middle East and North Africa. TiGenix is headquartered in Leuven (Belgium) and has operations in Madrid (Spain).
For more information, please visit www.tigenix.com
Forward-looking information
This document may contain forward-looking statements and estimates with respect to the anticipated future performance of TiGenix and the market in which it operates. Certain of these statements, forecasts and estimates can be recognised by the use of words such as, without limitation, "believes", "anticipates", "expects", "intends", "plans", "seeks", "estimates", "may", "will" and "continue" and similar expressions. They include all matters that are not historical facts. Such statements, forecasts and estimates are based on various assumptions and assessments of known and unknown risks, uncertainties and other factors, which were deemed reasonable when made but may or may not prove to be correct. Actual events are difficult to predict and may depend upon factors that are beyond the Company's control. Therefore, actual results, the financial condition, performance or achievements of TiGenix, or industry results, may turn out to be materially different from any future results, performance or achievements expressed or implied by such statements, forecasts and estimates. Given these uncertainties, no representations are made as to the accuracy or fairness of such forward-looking statements, forecasts and estimates. Furthermore, forward-looking statements, forecasts and estimates only speak as of the date of the publication of this document. TiGenix disclaims any obligation to update any such forward-looking statement, forecast or estimates to reflect any change in the Company's expectations with regard thereto, or any change in events, conditions or circumstances on which any such statement, forecast or estimate is based, except to the extent required by Belgian law.
Source: TiGenix


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Setanta UK Finished, Is America Next?
23 June 2009
Well the inevitable has finally happened; Setanta Sports UK is out of business. Soon after announcing Setanta UK had gone into administration, they were soon off the air. Less than three hours after first word leaked out that Setanta UK had gone into administration, all channels, with the exception of ESPN America and Racing UK, were taken off air.
So what does this mean? Understanding the Setanta Sports model, the company is broken into three separate sections; Setanta UK, Setanta Ireland/Northern Ireland, and Setanta International. While only Setanta UK is in administration, what it does mean is if needed, the other two sections of Setanta can be sold off to satisfy debts in the UK.
I can only go on gut feeling here, so here goes nothing. Unless a buyer is found within the next few weeks, Setanta Sports Ireland and Setanta Sports International will be out of business. Deloitte will want to move quickly to settle the debts left behind. With the massive amounts of debt Setanta UK is in (494.2 million US per Reuters), Setanta UK will end up being wound up when it's done. Setanta Ireland and Setanta International right now just became valuable pieces of property.
From every indication, both Setanta Ireland and Setanta International will be sold, and in short order. Thanks to the Irish Times, we have an idea on who could possibly be the front runner for Ireland; that company is Liberty Global. Now the name 'Liberty Global' may not ring a bell off the bat, but the companies they own are another story. In Ireland, Liberty Global are parent company of NTL. In the United States, Liberty Global own Direct TV.
Calling it a hunch, but if Liberty Global are going to purchase Setanta Ireland, they will also put a bid in for Setanta International. That would be good news all around. We would be able to keep our football coverage. Others would get to enjoy Aussie Rules, Rugby, and GAA the channel offers. Sure we lose Football Matters and the Friday Football Show, but it's a small price to pay to keep the sport we all love the most.
Now if they could only do something about that fifteen dollar a month price tag. I know I know, it's only wishful thinking.


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Acetylene is a fuel gas used in welding. It comes dissolved in acetone in cylinders and is very common in workshops, garages and maintenance facilities. Being a highly flammable gas, its storage and use is therefore subject to stringent safety precautions.
- Highly flammable
- Colourless
- Sweet garlic odour
- Non-toxic
Approximately 80% of the acetylene produced is used in chemical synthesis. The remaining 20% is used primarily for oxy-acetylene gas welding and cutting due to the high temperature of the flame. Combustion of acetylene with oxygen produces a flame of over 3300 °C (6000 °F) -- Oxy-acetylene is the hottest burning fuel gas.
Physical Properties
Acetylene, symbol C2H2, is a gas similar in density to air with an odour of sweet garlic. It is the simplest alkyne hydrocarbon, consisting of two hydrogen atoms and two carbon atoms connected by a triple bond. Because it contains a triple bond, acetylene is an unsaturated chemical compound.
|Chemical formula
|Molecular weight
|Gas density
|1.097 Kg/m3
|SG vapour
|Boiling point
|Critical temperature
|Critical pressure
|61.9 bar
Acetylene is produced by mixing calcium carbide with water. The resultant reaction is highly exothermic and must be cooled by adding extra water. Acetylene effervesces and calcium hydroxide (hydrated lime) is a further product. It is then purified and dried and dissolved into acetone soaked in a porous mass under pressure in steel cylinders. Acetylene is also produced in chemical plants but normally the gas produced in such plants is used as feedstock in the same plant for further chemical synthesis.
Acetylene is highly flammable and in high enough concentrations may also cause asphyxiation and death. Acetylene flames cannot be extinguished with water and are normally kept cool until the source of acetylene is exhausted. For more detail on the hazards associated with acetylene check the Safety Data sheet.


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The ARCA Racing Series presented by Menards visited Michigan International Speedway over the weekend for the 37th running of the #ZOMONGO 200.
Dodging rain which delayed both Saturday and Sunday's two top-tiered NASCAR series races, Friday evening's eighth ARCA event of the season went off without a hitch.
Michael Self led the three-car Venturini Motorsports stable with a finish of third, a strong rebound from his last ARCA Racing Series event at Charlotte Motor Speedway where Self finished in the 21st position after retiring from the race early due to a suspension problem.
After qualifying third, Self quickly jumped out front on lap-5 leading 23-circuits around Michigan's 2-mile track. Self extended his lead to over three seconds at one point, but came over the No. 15 team radio reporting a vibration around the lap 20 mark. After the first round of pit stops Self fell to second position, but the team had bigger challenges to face than the on-track competition. The Sinclair Oil Toyota got progressively tighter throughout the day, keeping Self from reclaiming the top spot. Self rode in the third position throughout the middle and end portion of the race, and would eventually hold the podium spot when he crossed the finish line. The top-five finish was the fourth for Self in five series starts this season.
"I don't know what happened," said Self. "We were super-fast for the first 20 laps or so, then we started to get a bad vibration, then we got super tight and never really got it back. It was definitely frustrating, because we were dominant at the start, and never faced any real handling issues throughout practice. We salvaged a good day out of it in the end, but hate that we came out scratching our heads on this one. Despite all that I'm happy to represent the folks at Sinclair Oil with a strong run and putting their car out front; it's always fun to run good for them."
Self, running a limited schedule, will return to the track on June 28 at Chicagoland Speedway.


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Job Description
Peoplebank are currently looking to engage a Project Co-ordinator / Project Support Officer for a 6 month engagement, starting in January 2018.
Working on a high visibility and business critical project, you will assist the Senior Project Manager to create a standardised process for implementing change, as well as helping business units to implement change in their areas; and managing a large amount of paperwork relating to approvals and correspondence in an orderly and auditable way.
The project will be supported by a robust project management process which the role will administer in line with guidance provided by the PM and PMO.
To be suitable for this Project Support / Project Co-ordinator, you should have the following skills/competencies:
- Ability to take responsibility and work proactively with limited supervision whilst maintaining transparency and asking for direction as required
- Intermediate skills in MS Project and ability to keep schedules up to date on a daily basis, and keep track of the progress of multiple complex tasks
- Ability to draft good quality documents of various kinds, sometimes with limited guidance on format and sometimes using a standard template
- Intermediate skills in Excel, ability to manipulate and undertake basic analysis of complex data and information
- Very good attention to detail and accuracy, ability to relate complex detail to the 'big picture'
- Very good people skills - will need to chase staff at all levels for information and status updates
- Understanding of and competency in using standard project management approaches and templates
Apply Now via Seek, for our immediate consideration.


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We all know that even a bad cold makes life significantly harder: The smallest problems loom large and we feel awful. Poor sleep can leave us feeling more troubled and anxious than usual.
When severe illness strikes, this whole-life impact is magnified. It's no surprise, then, that Canadians who are diagnosed with multiple sclerosis (MS), people like Heather, need help managing their complex medical treatments.
As we approach the fall equinox (September 22nd, when fall begins and the hours of sunlight equal the hours of darkness), many of Canada's Indigenous communities will pause to give thanks, for the fall harvest, for the longer hours of sunlight that the summer season has provided, and to mark the passing of the sun's annual cycle into its next phase.
With the kids heading back to school, here are some tips to help keep them safe and sound while they readjust to a new routine after the summer break.
Chips and pop are not food groups – healthy eating at school
Although healthy eating is something we should do all the time, kids may get into bad habits during summer break, when they have more freedom to choose their own snacks. Back to school is a good time to get the kids back into healthy eating habits.
Meet Brad. Brad just turned 56 and is a mid-level manager with a tech firm in Southwestern Ontario. He's always been relatively healthy, and he believes that he has an excellent drug plan. But he does have a family history of type 2 diabetes, and he worries what the health and cost implications would be if he had to take medication on an ongoing basis.
It's one of the worst kept secrets going:
Being active can help reduce your weight, blood pressure, blood sugar and cholesterol.
It can reduce your dependence on medication and lower your risk of heart attack, stroke and a number of other health issues.
Essentially, regular exercise can help you be healthier, feel better and live longer.


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Is your iphone stuck in headphone mode, are you unable to hear sound?
Solutions 1:
If you see the headphones icon on your display even after adjusting the volume buttons, check for the broken piece or dirt in the headphone port.
To resolve this plug in and unplug the headphones several times at least for 8 to 10 times. Use vacuum cleaner or hair dryer to remove dust from it. Even you can use toothpick to remove broken piece.
Solution 2:
If you spilled any liquid like milk or Pepsi, it will struck in headphone mode.
Use any q-tip, (stick with cotton end).
Solution 3:
Use any iphone compatible headphones and play a lengthy song. Wait till your iphone lock completely.
This will allow your phone to recover your iphone.
Solution 4:
Plug your headset when your iphone is locked.
Hold your power button. This will open slide power bar.
Now unplug your headphones.
Now tap on the cancel button at the toe end of the screen.
Now look at the headphone symbol on your display. It may resolve your issue.
For More How to Information Visit Website. You Will Get All the Updates Here.
Solution 5:
Hold your power button and home button for some time. This will move your device to recovery mode.
Solution 6:
Connect your iPhone to any Bluetooth speaker system.
For a better experience go by branded speakers.
Play a song on your iphone.
Meanwhile switch your speaker system back to phone, this may help you out.
If you still facing this issue, kindly write us below. We will get to you on this with a much working solution.


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It's been a big few months for the Flipbook team with our recent office move, nominations for the Roses Creative and Big Chip Awards, and addition of two new edit suites. We're now thrilled to have won the Best Animation/Graphics Company award at the Prolific North Awards! This is the third time we have won the accolade after our successes in 2014 and 2016 and the team couldn't be more delighted.
We were up against some seriously talented competition, but were praised by the judges by our recent expansion into a new studio space, increased turnover and recent investment in staff and technology. We are humbled and thrilled that all of the team's hard work over the past year has been rewarded.
You can see the full list of winners here: http://www.prolificnorthawards.co.uk/2017-winners


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Designer News
Where the design community meets.
over 3 years ago from Ahmet Sulek, founder @ usepanda
I've been using this app for the past 3 months and it's been great. Wraps up all of the news sources I care about into nice clean feeds. It's definitely been fun to see this come along.
Thanks for all the feedbacks and testing, much appreciated!
Designer News
Where the design community meets.
Designer News is a large, global community of people working or interested in design and technology.
We're Tiny Boards along with We Work Remotely, Unicorn Hunt, Fresh Gigs, Future Jobs and more.
Get in touch.
Have feedback?


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Which of us does not dream of ideal and at the same time sound body?
The majority of us dreams (especially it concerns fine half of mankind) that our figure will cause enthusiastic views of opposite sex, skin will shine health, and the mood from all this will be lightened up just every second.
However, quite often the reality afflicts us. Especially often it occurs in the most wonderful time of year – in the spring when on the contrary there is a wish to look for all 100%. And, naturally, that the majority of us begin to think of diet at once, and diet of the most cardinal i.e. that at once in week of-5-7 kg. But whether it is correct?
Of course, no! The organism so experiences the enormous strain connected with gipovitaminozy, transition to summertime, change of hormonal background, and here still ourselves add problem, sharply limiting ourselves in food. How to do right thing? To make the correct decision, it is worth deciding on what in general we can undertake for a start?
There is set of ways of weight loss.
One of ways of weight loss is the use of special tablets. Many treat such preparations as to miracle, and naturally expect from them just incredible effect. But most often, it does not occur.
All tablets can be divided into several groups:
- reducing appetite. These preparations oppress feeling of hunger at the level of the central nervous system. However these preparations are applied only at the people who really have vital issues with increase in weight and are appointed only according to the decision of the doctor;
- removing or interfering absorption in organism of fats. In principle the essence of action is not so bad, however this group of preparations rather expensive, and one of side effects is incontience calla. Not really pleasant characteristics;
- the additives having laxative or diuretic effect. As preparations for weight loss, this group it is possible to apply once if it is urgently necessary to get rid of couple of extra kilos. However, for long-term therapy they are absolutely contraindicated since they together with waste products bring out of organism and the mass of useful substances.
Thus, we draw conclusion: more simply and more usefully about this way it will be simple to forget.
The next way of weight loss is all favourite diets. It is difficult to imagine the person who will tell that he never kept to diet. Here only on what?
Diets there is absolute set. Even if it will want to write about everything, then it cannot almost be made. However, all diets in certain measure can be classified.
Type 1. Elementary starvation. The most extreme and aggressive look of weight loss. The organism begins to devour literally itself. Except that this way to lose weight is extremely painful, it also is harmful.
As if we did not want, but at once there is consumption of power materials not of problem zones. The organism begins "to rob" for example brain, etc. I.e. those bodies without which physical life activity will not break. And as result: the person turns into the zombie. In such state it is not far also to clinic.
Type 2. Different monodiets. Are less aggressive, but too are in some way harmful. The principle of action is that we give to organism nutrients, but we give in the form of, most often, proteinaceous or slozhnouglevodisty component (porridges, kefir, apples, etc.). As long diet naturally such way is unacceptable, but as fasting days – is irreplaceable. Even to pregnant women at excess set of weight 1 day a week is recommended to keep to diet of this sort.
Type 3. Principles of separate food. I think this way to explain to nobody it is necessary. The organism receives in principle the majority of nutrients, only in certain sequence and at different times. In principle there is nothing bad in separate food. Ah yes! Cost. Good separate nutrition after all is too expensive for the majority of us.
Type 4. Vegetarian diet. You should not confuse this diet to vegetarianism. During diet you specially limit receipt in organism of number of nutrients, to be exact completely exclude proteins. As all of us know, proteins is the most valuable construction material of organism. It is contraindicated to exclude them at young age. It can not only lead to decrease in body weight, but also lead to violation of activity sexual, immune and some other systems. After 45-50 some decrease in amount of the received protein is even useful, but not full.
Type 5. The diets based on features of organism. Each person is unique and unique system. It seems the processes happening in organism are identical physiologically, but there are they at everyone to the exclusive features. These types of diets are also based on understanding of these features.
As example it is possible to give diet on blood type. Its principle is that people with different blood type have to eat products mainly of one food group. The base of diet is based that blood types formed at people in the course of evolution upon transition from one step to another. When people were mainly meat eaters, all had only the first group. With transition to settled way of life and development of agriculture the second was created, etc. The diet mechanism as if is based on genetic memory of the person. It is not necessary to limit itself in number of eaten, and in normalization of the process of digestion of food and improvement of metabolism.
It should be noted that the diet on blood types is not "emergency", as well as the majority of diets of this group. You receive notable result only 2-3 weeks later, and even it is more. However, continuing to eat properly, you will be able to control the weight and at the same time to revitalize organism that in itself very much is not bad.
It is necessary to carry to this group of diets also astrological diet. Its principle is based that all zodiac signs can be divided on man's and female. At each group digestion happens to different speed, and, therefore, and they have to eat differently. If signs of men's group have to eat on time and to do it more often, then signs female should eat food only on internal feeling of hunger.
Besides, it is necessary to adhere to certain ritual of meal. To improve digestion fiery signs should give before acceptance of food to organism small physical activity. It activates digestion processes. Signs of the earth and water on the contrary have to eat food only being able full, both physical, and peace of mind. Only then digestion will be correct.
Astrological diets have not found broad application, yet however why not to try?
Type 6. In fact it is not absolutely diets. The diet implies refusal of certain components of food or its restriction. It is better to call these diets just the principles of the balanced food. What can be carried here?
Excellent example is so-called
Mediterranean diet
It is the whole power supply system based on the use of certain groups of products. It has been called so because initially is based on the main food of inhabitants of the Mediterranean. In due time several scientists have conducted researches and have found out that inhabitants of this region have much less mortality from warmly - vascular diseases and in general their percent, per se, among indigenous people is not high. Having conducted number of researches, scientists have come to conclusion that such combination of products well influences work of cardiovascular system, reduces the content of cholesterol in blood and just revitalizes organism.
What is inhabitants of the Mediterranean eat? If just to list products, then it will become banal terribly and unclear: and where here something useful? Large amount of oil, wine, cereals in the form of grain and as a part of bakery products, macaroni. It is not necessary further.... The terrible set, but if to begin to consider on points, then everything will become clear at once. So.
For a start we will be defined that the overall balance of nutrients has to make: 60% carbohydrates, 30% fats, 10% of squirrel. Quite so with little changes. It is necessary to eat according to such scheme not 1 and not 2 months. It is desirable to adhere to diet long time.
Further main ingredients.
Oil. And at once we will make a reservation: oil, and olive is not simple. It contains in the basic monounsaturated fats (unlike animal fats) which reduce the level of "bad" cholesterol in blood, by increase at the same time in the level of "good" cholesterol in organism. I.e. the positive balance of fats is recovered, and then there is direct increase in concentration of cholesterol to blood. This direct protection against atherosclerosis and the related complications from outside warmly – vascular system. Add to it that olive oil contains just huge amount of the vitamin E possessing antioxidant abilities, and you gain complete idea of advantage of this product.
Additional source of fats in organism in the Mediterranean diet is also the fats used in fish. Fish is admissible not everyone. In the Mediterranean the most popular types are deep-water types: mullet, cod, etc. To contain in fat of these breeds of fishes so-called fatty acids "omega-3". They also possess ability to reduce cholesterol level. It is necessary to make a reservation that you should not prepare fish for preservation of usefulness together with eggs, flour and other pleasures of our kitchen. The best way is suppression with addition of small amount of olive oil, vegetables or roasting.
Meat products, per se, rarity in the Mediterranean diet. If they are also used, then only in the form of low-fat mutton or veal, chicken meat is more rare. Frequency of the use 2-3 times a week (it is better - more rare) in the small portions.
The following item – paste. Or easier to say macaroni. Here, besides, a lot of things depend on grade of pasta. It is important to buy only products from firm grades of wheat which are good source of cellulose (which to the word normalizes digestion better than any "Aktiviya"), complex carbohydrates, vitamins of group B and magnesium.
Except paste complex carbohydrates come to organism from bakery products (besides baked of firm grades of wheat), cereal cultures (rice), qualitative dry breakfasts.
Vegetables and fruit. So it has turned out that vegetables and fruit of yellow-orange-red scale grow in the Mediterranean mainly. One of the most favourite products of this category is – tomato. It is fine source of lycopene. Even in small concentration lycopene renders positive effect on cardiovascular system. Also you should not forget about excellent influence of lycopene on male reproductive system. This substance simply universal "defender" of our men from oncological diseases of prostate. You should not think that tomatoes should be used only in the raw. Just on the contrary. In the course of preparation useful substances gain those qualities about which it was written above.
Except tomato you should not forget about pepper, lemons and other citrus. They can be used independently, and in the form of dishes. It is possible to prepare freshly squeezed juice, and it is possible to experiment with addition them in different classical recipes.
If you lack highlight in the Mediterranean kitchen, then it is not necessary to be upset. Practically all recipes allow (and even provide) addition in dish of different spices and herbs. Spinach, thyme, garlic, etc. are the most popular. The majority of spices are not only aromatic additive to food, but also the whole well of useful substances. For example, garlic contains phytoncides in the structure. These are powerful antibacterial, and also antiviral substances. Besides, garlic contains large amount of useful vitamins and minerals.
The thyme is one of the most useful spicy herbs. It contains big concentration of antioxidant substances in the structure, besides as well as garlic possesses antibacterial and antiviral action.
Rockets and other dark and sheet salads are rich with antioxidants, such as vitamins C, E, and also beta carotene. All of them delete the free radicals which are formed over time and also at stress and bad diet in any organism.
Properties of lemon all of us know since the childhood. Concentration of vitamin C in lemon almost maximum. It is irreplaceable antioxidant.
If there is no opportunity to buy spices in the raw, that is excellent alternative – dry seasonings. Only upon purchase attentively read structure. In qualitative seasoning there should be no additives.
And, at last, one of the most favourite points of the Mediterranean diet – wine. This traditional making menu of inhabitants of the Mediterranean. At once it is worth making a reservation that it is possible to drink only 1 glass a day for women, and 2 glasses for men. Such quantity of alcohol will promote the correct digestion: to improvement of motility of intestines, moderate stimulation of release of different digestive enzymes.
Also for a long time it is proved by scientists that small concentration of alcohol are capable to render positive effect on warmly – vascular system: to reduce amount of cholesterol in blood, thereby interfering with emergence of atherosclerotic plaques. The main thing is moderation here.
Wine is served most often at dinner or dinner. It is desirable that it was young dry grape wine. Inhabitants of the Mediterranean consider pure natural wine almost as panacea. It contains set of vitamins, minerals, and also legkousvayevayemy sugar.
If to speak about proteinaceous component of the Mediterranean diet, then It is necessary to tell that it also has the features.
Of course, the considerable part of proteins treats fish. However, it is impossible to forget about such important suppliers of protein as bean. Without them in general it is difficult to provide the Mediterranean menu. Any soup, broth or soup, beans is everywhere. Though bean also contain rather large amount of carbohydrates, in lump they are so imperceptible that it is quite possible to allow to use them in such quantity.
And, of course, it is worth remembering common truth of diets (including Mediterranean):
And if you have also added garnish, then it just has to be twice less.
Here, perhaps, and main components of the Mediterranean diet. You should not think that even within 2-3 months you feel full decrease in body weight. However, the feeling of ease, lack of problems with digestion, improvement of the general health is guaranteed. Besides the general indicators of fatty exchange including cholesterol level in blood, will be returned to normal over time. And it will positively affect state warmly – vascular system.
There is still huge number of various diets, but to observe them often very difficult if not to help organism to burn excess calories. And how it can be made? Naturally, carrying out certain physical activities.
Physical activity is and there is the third way of fight against excess weight. It is necessary to tell that it is the most correct and optimum way of weight reduction, of course, at observance of certain moderation.
Any physical activity is loss of calories, question: how many you lose? When performing usual actions, we generally or compensate power expenses by the energy arriving with food, or we exceed even the minimum necessary quantity. All this leads to the fact that our weight gradually grows. If to consider that with age the required amount of energy decreases, and the quantity and quality of the arriving food often does not change, then the reason of increase of weight is clearer.
Here to the aid physical exercises can also come. Also it is not obligatory to go and register at once in the best fitness at all – club. For a start try to act by own efforts. You go to work and from work on foot, try to get out more often to walks in park, eventually, it is possible to get rollers or the bicycle.
What type of weight loss you would not choose, remember that, first of all, you grow thin to become healthier. Therefore choosing for itself the most acceptable way, it is worth reflecting that in such business the shortest way does not mean the best and correct. Let you will spend more time for necessary weight reduction, but keep, and even improve own health and mood, and, of course, over time you will get rid of such undesirable folds. And can these folds and there is your "highlight"?


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October 14, 2008
Traditional marketing in the business-to-business environment requires very different strategies from those campaigns directed towards the consumer market. The sales cycle is often much longer and more complex in the B2B world, while consumer competition can be a lot fiercer, with customer loyalty a constant battle. In this article we compare the differences between B2B and B2C email marketing and examine which techniques work best for each.
Posted by Paul Latham
How to craft the perfect re-engagement email: Topshop example
In an ideal world, everyone on your list would be eagerly awaiting your email. They…
Jenni Malley
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How To Get Your Perfect Email Template
If you send email campaigns then you probably use a template. Not every email campaign…
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- About FSPH
- Current Students
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- Alumni Affairs
- Give to the School
Dr. Gerald Kominski, FSPH professor of health policy and management, was quoted in a Time magazine article about Trump's goals for 2018, which include repealing the ACA's individual mandate.
The tax plan repeals the individual mandate — a key part of Obamacare that penalizes people without health insurance — beginning in 2019. It's not true to say that the tax bill repeals the health care law, which congressional Republicans have repeatedly tried and failed to do. Experts say Republicans' previous inability to repeal the full law probably presages a failure again this year.
"I don't see anything that's changed in terms of the lack of support in the Senate," says Gerald Kominski, director of the UCLA Center for Health Policy Research. "I think that it is fruitless to continue to bang your head against the wall if you are not going to get the outcome that you want."
Read the full article from Time magazine.
Photo by Hush Naidoo on Unsplash


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Shadow Correspondent
JAMMU, Jul 16:
Condemning the attack on a Sikh girl and subsequent attempt to force her to change her religion in Kashmir valley, Ex-Minister and MLA Basholi Choudhary Lal Singh expressed surprise over the silence of the so-called secular leaders of Kashmir valley who left no stone unturned to denigrate Dogras of Jammu region after the Rasana case.
"These communal leaders with bigoted mindset who called every Jammuite rapist and rape apologist should die with shame over how an entire community of Kashmiri Pandits was driven out of Kashmir valley and now, how attempts are being to force another community out of Kashmir. These attempts would not succeed and Dogras would not let people with communal agenda succeed. Governor N.N.Vohra should take cognizance of this issue and take strict action against those who are stooges and agents of religious fanatics and Pakistan," said Choudhary Lal Singh in a statement issued here today.
He added "The brave girl who stood-up against the religious fanatics is an inspiration for many others and more importantly, for we Dogras who are seeking Justice for the 8 year old Goddess of Rasana who was brutally murdered. This incident has exposed the so-called communal leaders of Kashmir valley who left no stone unturned to malign Dogras of Jammu region. Those who came all the way from valley to vitiate atmos
Silence of Kashmiri …..
phere of Jammu region found no time to visit this brave Sikh Girl and report her plight to the whole world. Had she not taken to social media, no one would have ever come to know about this incident of highly communal nature."
"I commend this brave Sikh Girl and assure her that Dogras are with her. She should remain assured that we are solidly behind her. If she wishes to pursue her studies here, we would ensure that all possible arrangements are made for the same. Dogras should use social media and explore all other possible ways and means to assure the brave Sikh girl that we are with her. And the government should take strict action against those fanatics who tried to force this girl to change her religion," said Choudhary Lal Singh while adding that those who used to shed crocodile tears over Rasana have got exposed.
"Look who was talking about honour and dignity, someone who has not spoken a word about the plight of this Sikh girl. She tried to use Rasana to show how much she cared for the girl child but her silence after having lost power speaks in volumes about how communal her style of functioning was. She tried to use Rasana to resurrect her image and convince fanatics in Kashmir valley that she was their leader. And she and her party alongwith other so-called leaders of Kashmir valley are silent since they have always pursued a religious agenda under the garb of secularism. They have always preferred to stand alongside fanatics and religious zealots," said Choudhary Lal Singh.
Asking people of Jammu region to remain united and desist from following people with divisive agenda, Choudhary Lal Singh said "Be careful! A coterie of thugs is trying to divide we Dogras. Be on an alert and don't let them succeed. We have won half the battle and a little more patience would ensure that we win the battle hands down. CBI probe will be ordered in Rasana case and I know that they have no option but to order the same at the earliest. Let us not lose and be assured that CBI would soon take up the Rasana case and bring the reality before the people."
Silence of Kashmiri leaders over attempt to forcibly convert Sikh girl explains why CBI probe was denied in Rasana case: Lal Singh
Shadow Correspondent


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What Really Impacts Financial Success – A Reading List
Recognizing flaws in your thinking, making the best decisions and forming good habits are all important in achieving financial success. Here are some great books to help you accomplish those goals.
Attribution Analysis – Assessing Investment Decisions
If you want to improve your investment decisions, you need to quantify the impact of those decisions. That's where attribution analysis comes in.
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Recently a client asked how his portfolio was doing, and my answer was that he was doing well because the portfolio return over the last decade was above the return target he had established in his financial plan. So, after a decade of work, contributing to retirement...


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We held a lively pep rally to recognize all of those who participated in fall sports (soccer and cross country) on Thurs. Oct. 11. At that time Mr. Daly let the students know that the Pittsburg/Canaan Yellow Jackets had won an important award...the 2017-2018 NHIAA Sportsmanship Award! Great job, everyone!
Home > Photos of Fun at Pittsburg School >


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The Hidden Truth About Madden NFL Overdrive Uncovered
Performances of each the characters that are important and the voice acting, Wade especially, are solid. Players may finally make their draft courses! For some, the feature that is new is going to be the Draft Class Creator.
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As a player, you've got to make the decision as to move toward the National Football League. Actually, for nearly all its very, the NFL had a image issue. There was as soon as the Madden series was not a institution that is seasonal.
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Mostly because it's been a issue of sorts for a few decades now. Previous years have had greater way of seeing this info. Madden 19 can be a number of things based on who's playing with it in the current time, and that's just a terrific thing.
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The Chronicles of Madden NFL Overdrive
Just make sure to kick at the ball with total power on the meter to make sure it goes beyond the inner field. It permits players to play each game in a decrease difficulty, making running and gunning only a little bit simpler to manage. You'll start off with an all-gold team and are going to have the ability to raise your roster over the class of 15 rounds.
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Scroll to the correct and you'll observe the 10 decoration collection. Most the camera shots were the exact same, including the exact same behind-the-back coach shot from the sideline which I saw in a specific game over eight times. There aren't as many bunkers on Bethpage as you will find on a range of the WGT classes but should you do find the sand you probably will have an shot.
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Evaluations appear to matter more in the game of this calendar year than in versions that are various. Modern players may be accustomed to playing with their games with commentary.
Winning the tournament will offer three League-vs to the participant. We would like to bring you the very best Entertainment you can ask for. Players also be provided a Kick Off pack in case the new season begins.
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Chronicles of Madden NFL Overdrive
You'll earn scores, which means that you get points that you do on the region. How Longshot functions as the game's training mode is likewise an imperfect solution, and it is a true shame to get rid of a dedicated mode to dig into the controls. Removed to flick the R-Stick to pump fake once the player is outside the pocket.
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French President Emmanuel Macron on Sunday marked 75 years since the roundup of some 13,000 Jews to be sent to Nazi death camps, calling France's responsibility a "stark truth" at a ceremony attended by Israeli Prime Minister Benjamin Netanyahu.
Speaking near the former site of the Velodrome d'Hiver, the indoor cycle track from which the Jews were deported in 1942, Macron said: "It is indeed France that organised" the roundup. "Not a single German" took part.
Netanyahu's presence at the ceremony sparked controversy, with the Union of French Jews for Peace (UJFP) calling the invitation "shocking" and "unacceptable".
The UJFP accused the Israeli government of "usurping the memory of the victims of Nazism to make people believe that Israel represents all the world's Jews".
The ceremony marked the day when officials of the Vichy regime in Nazi-occupied France began rounding up 13,152 Jews and taking them to the Velodrome d'Hiver, an indoor cycle track in Paris.
Fewer than 100 of those who were detained at the so-called Vel d'Hiv and then sent to the Nazi death camps survived.
Macron was the fourth French president to accept blame for France's role in the deportations -- which totalled more than 75,000 -- since Jacques Chirac first did so in 1995.
"Time does its work," Macron said. "Archives open (and) the truth comes out. It's stark, irrevocable. It imposes itself on us all," Macron said.
- 'Sacred honour' -
Netanyahu hailed the "special heroism" of the French resistance to the Nazis, praising the "noble French citizens who at great risk to their own lives" saved thousands more Jews from perishing in the death camps where at least six million would die overall between 1941 and 1945.
"For the sacred honour of those who perished... let us remember the past, let us secure tomorrow," he said.
"The strength of Israel is that it is the one certain guarantee that the Jewish people will never undergo a Holocaust again."
Among other critics of Netanyahu's presence was former French ambassador to Israel, Elie Barnavi, who told AFP it made him "a little uneasy". He added:
"This story has nothing to do with Israel."
Among Sunday's other speakers were prominent French Nazi hunter Serge Klarsfeld and Pierre-Francois Veil, son of Holocaust survivor and rights icon Simone Veil, who died late last month aged 89.
Netanyahu's visit is the first since he joined a massive march attended by numerous world leaders held in solidarity with the victims of the January 2015 terror attacks on the Charlie Hebdo satirical magazine and a Jewish supermarket.
He was to hold talks later Sunday with Macron, the first since the French president's election in May.
Macron met Palestinian leader Mahmud Abbas on Wednesday, when he reiterated both France's support for a two-state solution to end the Middle East conflict, and its opposition to Israel's building of settlements in occupied Palestinian territory.
Netanyahu arrives just after a surge of violence in Israel, where a gun attack by three Arab Israelis in Jerusalem's Old City Friday left two Israeli police officers and the attackers dead.
He is expected to sound Macron out on his position on the Israeli-Palestinian conflict.
But it is not yet clear whether Macron will follow the pro-active line taken by his Socialist predecessor Francois Hollande, whose efforts to mobilise the international community on the question angered Israel.
Talks between Israel and the Palestinians have been at a standstill since the failure of US mediation in the spring of 2014.
Since then the Israeli-Palestinian conflict has simmered on, with the occasional surge of violence such as Friday's killings.
The two leaders are also expected to discuss Israel's arch-foe Iran, in particular Tehran's role in the Syrian conflict, where it is backing President Bashar al-Assad.


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Why Two Way Radios are Important for Your Firm.
Two-way radios were in use long before the smartphones were introduced. Additionally, you can still use them even in this cell phone era. In job site, mobile phones are often used in communication because they are multi-functional and even convenient. However, the best option is still the two-way radios. You will not have cell service and the landlines won't be useful when an emergency has occurred. Given that two-way radios do not need the cell service towers to operate, communication will not be interrupted even during that time. In an emergency situation, the purpose of the rescuers or anyone who is in a position to help is to reach as many people as he or she can at once. When it comes to these radios, you will be able to reach everyone who is in the surrounding. This will not be the case for those who are using cell phones because it requires you to dial a specific number depending on who you want to contact. If the information is passed to a specific person who should let the rest know, there might be inconveniences when he or she forgets and at times the message has been changed in the process of passing it along.
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These radios are not as expensive as the mobile phones. There are some mobile phones which cost even one thousand dollars and above and those will drain the firm's budget if you ought to get them. Another great thing about two way radios is the fact that they do not require you to pay any monthly fees, calling minutes or even service contracts. In addition, there is no need to buy one radio for every member of your team because one is enough for the entire department. Another merit of the two way radios is the fact that the messages to be passed across will be clear despite the environment or weather conditions. You can discover more about two-way radios here.


text: ENID, OK – Tuesday, February 7, 2017 – Happy Wave All Your Fingers at Your Neighbor Day! It's also "e" Day, African American Coaches Day, Ballet Day, Black HIV/AIDS Awareness Day, Rose Day & Send a Card to a Friend Day! Foodies enjoy Fettuccine Alfredo Day! – This morning we took some promo shots for … [Read more…]