text:
- Original research
- Open Access
Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers
© The Author(s). 2016
- Received: 24 August 2016
- Accepted: 14 November 2016
- Published: 25 November 2016
Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study was to investigate the challenges and feasibility of pre-clinical quantitative imaging and mouse-specific dosimetry of 111In-labelled radiotracers.
Attenuation, scatter and partial volume effects were studied using phantom experiments, and an activity calibration curve was obtained for varying sphere sizes. Six SK-OV-3-tumour bearing mice were injected with 111In-labelled HER2-targeting monoclonal antibodies (mAbs) (range 5.58–8.52 MBq). Sequential SPECT imaging up to 197 h post-injection was performed using the Albira SPECT/PET/CT pre-clinical scanner. Mice were culled for quantitative analysis of biodistribution studies. The tumour activity, mass and percentage of injected activity per gram of tissue (%IA/g) were calculated at the final scan time point and compared to the values determined from the biodistribution data. Delivered 111In-labelled mAbs tumour absorbed doses were calculated using mouse-specific convolution dosimetry, and absorbed doses for 90Y-labelled mAbs were extrapolated under the assumptions of equivalent injected activities, biological half-lives and uptake distributions as for 111In.
For the sphere sizes investigated (volume 0.03–1.17 ml), the calibration factor varied by a factor of 3.7, whilst for the range of tumour masses in the mice (41–232 mg), the calibration factor changed by a factor of 2.5. Comparisons between the mice imaging and the biodistribution results showed a statistically significant correlation for the tumour activity (r = 0.999, P < 0.0001) and the tumour mass calculations (r = 0.977, P = 0.0008), whilst no correlation was found for the %IA/g (r = 0.521, P = 0.29). Median tumour-absorbed doses per injected activity of 52 cGy/MBq (range 36–69 cGy/MBq) and 649 cGy/MBq (range 441–950 cGy/MBq) were delivered by 111In-labelled mAbs and extrapolated for 90Y-labelled mAbs, respectively.
This study demonstrates the need for multidisciplinary efforts to standardise imaging and dosimetry protocols in pre-clinical imaging. Accurate image quantification can improve the calculation of the activity, %IA/g and absorbed dose. Diagnostic imaging could be used to estimate the injected activities required for therapeutic studies, potentially reducing the number of animals used.
- 111In
- Pre-clinical
- Image quantification
- Partial volume effect
- Dosimetry
- Radiolabelled antibodies
Molecular imaging enables minimally-invasive visualisation of molecular and cellular biological processes in living organisms. It plays an important role in cancer drug development and in monitoring disease progression and tumour response to therapeutic interventions [1–3]. Animal models are both cost effective and versatile and therefore have been essential in cancer research. Ex vivo biodistribution and/or autoradiography studies are traditionally used to investigate the uptake characteristics of novel radiolabelled tracers prior to translation to in-human clinical trials. However, these methods are limited, as they require animals to be culled at various time points and the pharmacokinetics are based on data from different animals at different times. Conversely, SPECT and PET pre-clinical imaging enables the prospect of longitudinal studies and therefore has the potential to provide quantitative measurements of radiotracer biodistribution and to reduce the number of animals required per study, which is both more cost effective and more ethical than traditional methods [4].
Absolute image quantification is essential to evaluate imaging biomarkers and to accurately determine the distribution of the uptake of novel radiotracers to evaluate their toxicity and efficacy profile in small animals prior to use in human studies. It is also necessary for dosimetry calculations and therefore has the potential to improve our understanding of the biological mechanisms of radiation-induced cell damage [5, 6] and to better inform the comparison of therapeutic radiotracers. The accuracy of pre-clinical molecular imaging can be degraded by several factors including attenuation, scatter, partial volume, motion and animal handling [7]. The effects of attenuation and scatter are of less importance than in clinical imaging due to the smaller size of the subjects involved. However, multiple studies have shown that the effects can be significant for radionuclides emitting low-energy gamma rays and larger-sized rodents [8–13]. The spatial resolution of the imaging system also affects quantification due to the partial volume effect, particularly in the case of small animals. The majority of studies to investigate partial volume effects in pre-clinical imaging have focused on PET [14–16]. Few correction methods are available [17] and commercial imaging systems do not provide correction and/or compensation methods for partial volume effects.
The aim of this study was to explore the challenges and potential role of quantitative pre-clinical SPECT imaging as an alternative for biodistribution studies. Methods used in the clinical setting were applied to a pre-clinical study to investigate image quantification and mouse-specific dosimetry of 111In-labelled monoclonal antibodies (mAbs) targeting HER2-positive tumours. In particular, the influence of tumour size on quantification accuracy was investigated.
Immunoconjugate preparation and radiolabelling
The HER2-targeting mAbs used in this study were the commercially available trastuzumab (Herceptin®, Roche) and ICR12, developed at The Institute of Cancer Research, London [18, 19]. The bifunctional chelator 2-(4-isothiocyanatobenzyl)-diethylenetriaminepentaacetic acid (pSCN-Bn-DTPA, Macrocyclics, US) was conjugated to ICR12 and trastuzumab. Additionally, 2-(4-isothiocyanatobenzyl)-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (p-SCN-Bn-DOTA, Macrocyclics, US) was conjugated to trastuzumab. The immunoconjugates (50–80 μg) were radiolabelled with 111In (ca 42 MBq) (Perking Elmer, US) in acetate buffer (pH = 4). All reactions were performed as described previously [20, 21]. The use of different radioimmunoconjugates does not affect the results of this study, as the primary aims were to investigate the feasibility and challenges of image quantification and dosimetry in pre-clinical studies, rather than to compare the radiotracers.
Tumour cell line and animals
Radioimmonucongugate, level of activity (Ainj) and quantity of antibody (mAbinj) injected for the six mice included in the study
Mouse no.
Ainj (MBq)
mAbinj (μg)
Imaging study
Mice were anesthetised by inhalation of a 2% isoflurane/O2 mixture (Virbac, UK) and placed on the scanner bed. A 1% isoflurane gas mixture was maintained during acquisition. The imaging study was performed using the Albira SPECT/PET/CT tri-modal pre-clinical scanner (Bruker), which allows fully registered anatomical and functional imaging [22, 23]. The CT component is co-planar with the SPECT crystals and has transverse and axial fields of view (FOV) of 65 mm. The SPECT sub-system comprises two opposing heads, each with a single 100 × 100 × 4 mm2 CsI(Na) crystal and a position sensitive photomultiplier tube. All acquisitions were performed with a single-pinhole collimator and transverse and axial FOVs of 80 mm and 60 mm, respectively. An energy window width of 20% was placed on the lower gamma-ray emission of 111In at 171 keV. The scans were reconstructed using default parameters, the ordered subsets expectation maximization (OSEM) method with two iterations and five subsets into a 110 × 110 matrix with voxel size of 0.75 mm. The images were not corrected for attenuation, scatter or partial volume effects, as these are not provided by the manufacturer. The six mice were imaged at 4, 24, 48, 72 and 96 h post-injection (pi), and two mice were additionally imaged at 168 and 197 h post-injection. A CT (45 kV, 0.2 mA, 80 mSv) and a 15 min SPECT acquisition were performed at each time point.
Image quantification
In-built attenuation and scatter corrections are not available in the Albira system. Therefore, a simple phantom experiment was used to investigate their combined effect. A 2.3 mm-radius sphere was filled with 32.6 MBq of 111In (0.1 HCl) and attached to a 30.4 ml cylindrical phantom (diameter 25 mm, length 92 mm) to simulate a subcutaneous tumour in the flank of a mouse. The phantom was placed on a moveable platform adjustable to sub-millimetre precision and scanned in ten positions: five axial positions in the centre and five positions 8 mm off-centre from the FOV trans-axially. The experiment was performed with the cylindrical phantom filled with air and water. The mean counts in the sphere were compared for both cases to assess the effects of attenuation and scatter within the mice.
To quantify the level of activity in the in vivo SPECT scans, phantom studies were performed to convert from measured counts to units of activity (MBq). Three spherical phantoms with volumes of 0.03, 0.12 and 1.17 ml were filled with activity concentrations in the range of 7.7–10.2 MBq/ml of 111In (0.1 M HCl) to investigate partial volume effects and to calibrate the SPECT images. Each sphere was attached to a 30.4 ml cylindrical phantom (diameter 25 mm, length 92 mm) filled with 0.1 M HCl solution to provide a realistic scatter and attenuation medium.
Each phantom was scanned using a 15-min acquisition and reconstructed with the same parameters as for the in vivo study.
Image-based convolution dosimetry was performed using in-house software [24], developed in C# and C++, using the .Net framework and the open source library Visualization Toolkit VTK (http://www.vtk.org) [25]. Three-dimensional absorbed dose distributions were obtained from the convolution of a voxelised-cumulated activity distribution and a voxel S-value kernel. The SPECT scans were co-registered using a rigid mutual information algorithm, and these were used to obtain the time-activity curves and to calculate the cumulated activity at the voxel level. A trapezoidal or exponential extrapolation method was used for the intermediate phases, depending on whether the activity between the two time points increased or decreased respectively. For the uptake phase, it was assumed that the activity at the time of administration was zero and linearly increased to the first scan time. For the last phase, exponential decay with physical half-life was assumed from the last scan point to infinity to avoid any bias introduced by registration errors and redistribution of uptake at the voxel level. Voxel- S value kernels were generated with an application developed using the EGS++ class library within the general purpose EGSnrc Monte Carlo (MC) code [26, 27], previously validated by comparison with available resources [28]. Kernels for 111In and 90Y with 0.75 mm voxels in a soft-tissue homogeneous medium were generated. Simulations were carried out without variance reduction techniques and with 107 histories to maintain the statistical uncertainty below 1% at central and nearest neighbouring voxels. The decay spectra used for the simulations were obtained from the RADTABS software [29].
Due to insufficient contrast between the tumour and the surrounding muscle tissue on the CT images, tumours were outlined in the SPECT images using a thresholding method using the PMOD software (PMOD Technologies). The threshold was varied until the tumour edge in the SPECT scan matched the visible tumour edge in the CT image. The thresholded final SPECT images were used to calculate the tumour masses assuming a density of 1 g/cm3 and the tumour activity using the calibration curve obtained from the phantom experiment. The tumour uptake, determined as the percentage injected activity per gram of tissue (%IA/g), was then calculated from the activity and mass of the tumour at the final scan time point. The tumour absorbed doses delivered by 111In-labelled mAbs and those that would have been delivered by 90Y-labelled mAbs were extrapolated to demonstrate the feasibility of pre-therapy-image-based treatment planning for therapeutic studies. The assumptions of equivalent injected activities, biological half-lives and uptake distributions for 90Y-labelled mAbs as for the 111In-labelled mAbs were made.
Biodistribution study
The mice were euthanized by cervical dislocation immediately following the final scan: 96 h for four mice and 197 h for the remaining two mice. The tumours were dissected and weighed, and the radioactivity was measured in a WIZARD2 automatic gamma counter (PerkinElmer, UK). Tumour uptake (%IA/g), activity and mass were calculated. Comparisons between the three radiotracers were beyond the scope of this study.
Comparison between imaging and biodistribution
The activity, mass and %IA/g in the tumour calculated from the last SPECT scan were compared with those obtained from the biodistribution study, which is considered to be the gold standard measurement.
Statistical considerations
Median and range were used to describe continuous variables. Pearson's correlation coefficients and regression analysis were used to quantify and identify relations between variables. Two-sided P values below 0.05 were considered significant.
Immunoconjugate preparation and radiolabelling
The radiolabelling of ICR12 with 99mTc, 124I and 131I has previously been reported [30–32], and this study demonstrates that it can also be efficiently labelled with 111In.
Imaging study
Image quantification
For the attenuation/scatter phantom experiment, the mean counts in the sphere were on average 3% lower in the presence of the water-filled cylinder than with the air-filled cylinder.
Mass, activity and uptake in the tumour determined from the biodistribution (bio) and imaging (im) studies and their relative percentage differences (diff), and delivered (111In) and extrapolated (90Y) tumour absorbed doses per injected activity (D/A) for the six mice included in the study
Mouse no.
Mass (mg)
Diff (%)
Activity (MBq)
Diff (%)
Diff (%)
D/A (cGy/MBq)
Biodistribution study
A median tumour mass of 83 mg (range 41–232 mg) was obtained from the biodistribution data, with a median activity of 0.093 MBq (range 0.015–0.335 MBq) and a median %IA/g of 48% (range 33–66%).
Comparison between imaging and biodistribution
This study investigated the challenges associated with pre-clinical imaging and mouse-specific dosimetry and compared the mass, activity and %IA/g in the tumour obtained from the imaging and the ex vivo biodistribution data. A statistically significant correlation was observed between the tumour activity and mass as calculated from the biodistribution and imaging data at 96 and 197 h following injection of 111In-labelled mAbs targeting HER2-positive tumours. However, a correlation was not found between uptake as calculated from the imaging and the biodistribution data. Finucane et al assessed the quantification accuracy of 111In pre-clinical imaging and concluded that imaging could replace some dissection studies for the assessment of radiotracer biodistribution in mouse models [33]. Their conclusions were based on a comparison of the tumour activity calculated from the SPECT scan and the percentage of injected activity (%IA) determined from the biodistribution data and therefore did not include the influence of the mass into the %IA/g calculation. The discrepancies in the uptake calculations observed in our study are not fully understood, and more studies are needed to assess the reproducibility of measurements and to elucidate the interplay of the different variables in the calculation of uptake prior to the complete replacement of ex vivo biodistribution studies.
Accurate calculation of subcutaneous xenograft tumour volume is a key element of pre-clinical studies, as it is used as a metric to assess tumour growth and to quantify response to therapy, as well as for image quantification and dosimetry. Our results showed that for the range of tumours observed in this mouse cohort, the calibration factor to convert from counts to activity changed by a factor of 2.5, which can potentially lead to significant errors in the quantification of tumour activity, uptake and absorbed dose. These differences are likely due to partial volume effects, as the median tumour diameter observed in this study was 5.4 mm (range 4.3–7.6 mm), and the measured average axial spatial resolution for 111In was 2.1 (±0.4) mm. The investigation of the combined effects of attenuation and scatter showed only a 3% error on image quantification, which is small compared with the limitations of the spatial resolution and partial volume effects. Attenuation and scatter will play an important role for larger size rodents and low energy emitting radionuclides. For example, Hwang et al found that the measured concentration of activity in a volume of interest in the centre of a rat-sized water-filled cylinder was reduced by up to 50% for 125I and up to 25% for 99mTc [9]. Our study was limited in that it only assessed the impact of attenuation/scatter, partial volume and limited spatial resolution. However, image quantification will also be affected by other factors. Optimisation of the number of iterations used for image reconstruction could lead to improved spatial resolution and thus reduce partial volume effects. Motion and image co-registration can also result in significant image blurring. It is therefore essential to standardise and harmonise the imaging protocols in pre-clinical imaging to decrease the variability in the calculation of tumour activity, %IA and absorbed dose, which are key parameters in the evaluation of novel radiotracers.
Tumour and organ masses can also have a significant impact on tabulated S values for organ and tumour-absorbed dose calculations. Several authors have studied the impact of various voxel-based mouse dosimetric reference models and found large variations in S-values due to the variability of the anatomical features [34–37]. Our study was based on convolution dosimetry, which accounts for heterogeneity in the uptake distribution at the voxel level. Tumour absorbed doses were calculated from outlining the absorbed dose distributions, neglecting tumour size changes that could occur following the administration of the radiotracer. Future studies could include magnetic resonance and/or ultrasound imaging to improve the accuracy and precision of tumour volume assessment [38, 39], which in turn will improve mass, activity, uptake and absorbed dose calculations.
The dosimetry methodology used in this study showed the feasibility of treatment planning in pre-clinical studies, where absorbed doses can be extrapolated for any radionuclide from a given uptake distribution. This could ease experimental planning for therapeutic radiotracers by informing the level of injected activity required to deliver a given absorbed dose, in particular for theragnostic agents, with the potential to reduce the number of animals used.
This study demonstrates the need for multidisciplinary efforts to standardise imaging and dosimetry protocols in pre-clinical imaging before replacing ex vivo biodistribution studies. Accurate image quantification can have a large impact on improving the calculation of mass, activity, uptake and absorbed doses and therefore has the potential to improve treatment response studies and the comparison of novel radiotracers.
The authors would like to acknowledge Kicki Frisch for her support on the development of the dosimetry software.
This work was supported by Cancer Research UK and Engineering and Physical Sciences Research Council support to the Cancer Imaging Centre at The Institute of Cancer Research (ICR) and the Royal Marsden Hospital NHS Foundation Trust (RMH) in association with Medical Research Council and Department of Health C1060/A10334, C1060/A16464.
Authors' contributions
The study was conceived and designed by AMDB, SEC, GDF and TS. CDP and RP were responsible for radiolabelling with the participation of AH and JKS. CB and GKM assisted with the cell and animal work, and SAE procured the ICR12 antibody. SEC and TS collected the imaging data. AMDB drafted the manuscript. AMDB and SEC analysed the data. All authors proposed valuable comments, revise the manuscript critically for important intellectual content and approved the final manuscript.
Competing interests
The authors declare that they have no competing interests.
Consent for publication
Not applicable.
Ethics approval
All experiments were performed in compliance with licences issued under the UK Animals (Scientific Procedures) Act 1986 and following local ethical review and the United Kingdom National Cancer Research Institute Guidelines for Animal Welfare in Cancer Research.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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text:
The Diverse Roles of Urban Agriculture - Case Study of South Durban Basin KwaZulu-Natal
Paris Marshall Smith
Email: email@example.com
Andreas Flach de Neergaard
Dep. of Agricultural Sciences; Plant and Soil Science
Noman Kanafani
Fødevareøkonomisk Institut / Afdeling for International økonomi og Politik
February 2006
Department of Agricultural Sciences
Royal Veterinary and Agricultural University
Thorvaldsensvej 40; DK-1871 Frederiksberg C, Denmark
On this web page, we have placed the Ttile, Abstract, and the Table of Contents from the paper. The complete thesis can be downloaded from the following two links. The first link is the title page (587 KB), the second, the main body of the thesis - photos, maps, graphs, (28.2 MB !!). Please NOTE, the thesis download is VERY LARGE - 28.2 MB. Be patient, it will download eventually. Both are PDFs.
Title: The Diverse Roles of Urban Agriculture - Case Study of South Durban Basin KwaZulu-Natal
Thesis Body: The Diverse Roles of Urban Agriculture - Case Study of South Durban Basin KwaZulu-Natal
Responding to the pressures of increasing levels of urbanization, urban agriculture (UA) is gaining popularity as livelihood strategy in South Africa. As yet relatively few studies have attempted to assess the role that urban agriculture plays or might play in South Africa. This study addresses the social, economic and political importance of urban agriculture in the heavily industrialized area of the South Durban Basin (SDB). Research suggests that resource accessible households use UA as a means of securing their assets for a variety of livelihood endeavours, not solely economic. These alternative endeavours include harnessing UA as a spatial tool for community organizing and social identification. Using a range of qualitative and quantitative methods, 3 socially and economically diverse communities in the SDB were investigated to determine the different motivations and types of local food production. Farmers from school and community gardens, individual backyards and informal plots were interviewed. Soil potential and industrial emission dispersion rates were investigated through interactive mapping techniques. Analysis of soil material taken from the gardens was conducted to detect levels of heavy metal contamination. The levels of importance and scope of UA activity varied significantly between the different communities. The results indicate that current economic distortions resulting from historical discrimination are part of the variation in method and motive. The implications of these findings in terms of future urban planning and policy formulation are discussed.
Table of Contents
Chapter 1: Introduction
1. Introduction
2. Purpose
3. Objectives
4. Research Problem
Research Questions
5. Literature Review
a. Analytical Models
b. Areas for Further Study
6. Methodology
a. Social Science Methods
b. Natural Science Methods
7. Discussion of Study Sites and Methods
8. Structure of the Thesis
Chapter 2: Urban Agriculture (UA) Background
1. Background on UA
a. What is UA?
b. Where is UA Practiced?
c. Who Practices UA?
d. What are the Policy Considerations?
2. Potential Benefits from UA
a. Social
b. Environmental
c. Economic
d. Political
Chapter 3: Urban South Africa
1. Historical Urban Land Use Development
2. Urban Land Policies
a. Contemporary Urban Issues
3. Areas of Impact
Chapter 4: Local Context: Durban
1. Local Context
a. History of Durban
b. South Durban Basin
c. Government Policy on UA
d. UA in the Municipality
e. Study Areas
Chapter 5: Results
1. Introduction
2. Socio-Economic and Political Issues
3. Garden Management
4. Soil Nutrient Results
5. Environmental Results
Chapter 6: Discussion
1. Motivational Incentives for UA
2. The Framework
a. Social
b. Environment
c. Economic
d. Political
3. Summary
Chapter 7: Recommendations
1. Social
2. Economic
3. Environmental
4. Political
5. Collaboration
Works Cited
Appendix A - Questionnaire
Appendix B - Monthly Earnings
Appendix C - Soil Profiles
Appendix D - Samples sites, field notes and interview contacts
Appendix E - Heavy Metal Toxicity Charts
Appendix F - List of Crops found in SDB
Appendix G - Field Pictures
Appendix H - Definitions
Search Our Site

subset: commoncrawl


text:
Last night, I performed selections from my books, Muscle Worshipers (featuring my short story Enchanted Morning, and The Devil's Details. Hosted by the incomparable Renair Amin, it was "All Erotica Night", and Billie's Black Restaurant was packed! I always love performing at Billie's, because the staff are welcoming, the food is excellent, and it's a place where they accept you as you are! The audiences there always show me much love, and it's a privilege to come up to 119th Street and join other wonderful, talented people in putting on a show that rocks the house.
(Apologies for the low light!)
Renair and co-hostess Essence Woodard kept things popping all night long! There were so many fantastic artists on stage, and I do believe last night's show was among the best Renair has ever put on. We celebrated Billie's Black bartender Malik Baldwin's birthday, and re-affirmed our lives and loves as proud LGBT artists. Big ups to Pmyner for making it all happen!
Friday, February 19, 2010
Nathan James At SPEAK YOUR MYNE!
Posted by Nathan James at 9:30 AM
Labels: Arts, Authors, Billie's Black, LGBT, Nathan James, New York City, Pmyner, Renair Amin, Speak Your Myne
Subscribe to: Post Comments (Atom)


text:
Georgia Power said there are now about 8,000 personnel working around the state to restore power. "If you are still without power, we want you to know we are coming". "We thank our customers for their patience and support", FPL President Eric Salagy said. "Georgia Power continues to work with customers who are behind on payments or need to make payment arrangements through its usual customer service process", the statement reads. Read More »
Jamie Lee Curtis Returning For New HALLOWEEN Film
Universal said the 2018 film "carves a new path from the events in the landmark 1978 film", suggesting that it will ignore the events in the 2002 film. "He's gonna kill some more people". I had such a good cast and I got Jamie Lee Curtis back, so that's kinda' hard to beat. It needs no introduction at this point, and as fans will know, Danny McBride and David Gordon Green are getting ready to put their own spin on the classic. Read More »
Jennifer Garner gushing about Hamilton while high after dental surgery is priceless
Jennifer Garner and Ben Affleck may be no more, but we still love them both. The Dallas Buyers Club beauty is seen sitting in the passenger seat of a auto, talking in to a cellphone, almost uncontrollable as she lurches between laughter and tears whilst recounting a story. Read More »
Angelina Jolie a 'little bit stronger' after divorce drama
Following their giggle fest, the kids - Maddox , 16; Pax , 13; Zahara, 12; Shiloh, 11; Vivienne, 9, and Knox, 9 - posed for photos with Jolie and Ung, along with the film's stars, Kimhak Mun and Sareum Srey Moch . Maddox , who Angelina adopted from Cambodia in 2002, is listed as an executive producer on the film, and recently gave his first ever interview on what it was like producing alongside Angelina . Read More »
Aaron Carter Takes Drug Test On 'The Doctor'; Results Come Back Positive?
Carter's biggest concern: "I don't want this to come across as, oh yeah, he's an addict". "I think that things are only going to be better when you're better", Rodriguez said. Turning to the troubled singer, Travis said: "What scares me about that drug panel is that your sister [Leslie] perished from a drug overdose. These medications - and I'm speaking now purely from the doctor's perspective - can be very, very scary". Read More »
Husker Du's Grant Hart Dies at 56
Singer-songwriter Ryan Adams was among those artists, tweeting Thursday: "Your music saved my life". It's with me now. "Travel safely to the summerlands". After reminiscing about first meeting Hart and their relationship over the ensuing decades, Mould writes in part, "The tragic news of Grant's passing was not unexpected to me". Read More »
Woman gives birth alone at home during Hurricane Irma
Tatyanna Watkins, 23, thought she would have been fine riding out the storm at home because she wasn't expected to deliver until after the storm passed on Monday. The family was safely transported to the Women's Hospital at Jackson Memorial around 8 a.m. They were able to respond to every call that came in until midnight Saturday, when they made the hard call to keep crews in from the storm out of safety concerns. Read More »
Mandy Moore engaged to Taylor Goldsmith
I'm happy for her", Huertas told ET. "I love to change my hair because, in a world where so much is out of my control, it makes me feel like I'm doing something to shake things up". "Never not smiling with you, T", she captioned a joyful photo she shared to Instagram on July 12 to mark the couple's anniversary. CNN has reached out reps for Moore for comment. Read More »
Telugu Doctor stabbed to death in Kansas City of USA
Wednesday police responded to report of a stabbing at 625 North Carriage Parkway in Wichita, according to police Lt. Todd Ojile. A psychiatry doctor, Achutha Reddy hailing from Nalgonda was stabbed to death in his holistic clinic in East Wichita, Kansas, late on Wednesday night. Read More »
Fergie & Josh Duhamel Separate After 8 Years of Marriage
When Duhamel, 44, and Fergie , 42, chose to separate is not clear. In January, both Fergie and Duhamel shared Instagram photos in celebration of their eighth anniversary. In a 2014 interview with the site, Duhamel confessed that his first words to his wife-to-be were simply, "You're hot". " Fergie is definitely more evolved than I am, and more patient". Read More »
Red Sparrow Trailer Delivers A Very Different Jennifer Lawrence
She sits nervously on a bed, takes a sip of what we assume is a stiff drink, and seems almost petrified when a man enters and orders her to take off her dress. Jeremy Irons , Charlotte Rampling , our own Ciaran Hinds, and Joely Richardson all star in supporting roles, and there's also the fact that it's about Russian infiltrators - so it's definitely prescient in the current political climate. Read More »
Catalonia refuses to send weekly accounts to Madrid before referendum
Some eight hours later in Cambrils, a city 120 kilometres south of Barcelona, an Audi A3 vehicle rammed into pedestrians, injuring six civilians - one of them critical - and a police officer, authorities said. Catalan authorities routinely ignore the court's decisions as they do not recognise its legitimacy. He said the rights of all Spaniards will be upheld against "whoever steps outside constitutional and statutory law". Read More »
Jennifer Lawrence, Darren Aronofsky couple up at 'mother!' premiere
She revealed that they started seeing each other after the production of " Mother! " concluded. He said: "She's the only person who's allowed not to [wear black], 'cause she's life". Hence, she is hoping that this trait is a good thing for their blossoming romance. "I don't think that's how it's supposed to work!" she said. In fact, the actress said that she has not given it much thought as time passes by. Read More »
Trevor Noah Extends Comedy Central Contract Through 2022
He set new viewership records during the month of August, while the ratings for the 2017 calendar year also went up. Stewart, after all, was a late-night legend. Mr. Noah's incarnation of "The Daily Show " drew an average nightly audience of just over 1 million viewers for the week ending September 1, according to Nielsen, well short of the 2 million or more who tuned in for Mr. Read More »
3 children killed in West Sacramento; suspect arrested
More details will be coming soon. Roger Kinney says investigators have not determined if Hodges was the children's father. The children died at a West Sacramento apartment after 9 p.m. It's horrific, and it's very hard to deal with. Hodges is expected to be booked on three charges of murder and one county of domestic violence . The names and ages of the children were not immediately released, nor was their cause of death. Read More »
Comparable Company Analysis: Twenty-First Century Fox, Inc
The firm owned 127,569 shares of the company's stock after purchasing an additional 44,712 shares during the quarter. Meiji Yasuda Asset Management Co Ltd. The stock now has an average rating of "Buy" and a consensus price target of $33.43. On Tuesday, May 23 Shapazian Carole J sold $151,635 worth of Baxter International Inc (NYSE:BAX) or 2,618 shares. Read More »
Behati Prinsloo And Adam Levine Expecting Second Child
In November, the "She Will Be Loved" singer posted an adorable photo of him, his wife, and his newborn daughter overlooking the sea, with the sweet caption: "Everything I need is right here". It will be interesting to see if Prinsloo will still be walking in the Victoria's Secret Fashion Show this year. Prinsloo opened up about baby Dusty in May, describing her as "Heaven". Read More »
Has Meghan finally met the Queen?
Rumours of an impending engagement heated up even further last week when Meghan Markle gave a gushing interview to Vanity Fair about her love for Prince Harry . People assume that Harry and Meghan will make their first official appearance as a couple at the event. "A woman is not just a plus one", says Priyanka Chopra while giving her opinion on friend Meghan Markle's recent interview in Vanity Fair . Read More »
Check out the first look at David Harbour in costume as Hellboy
Holy crap! Your first look at the new Hellboy is here! Harbour has made a complete transformation into Dark Horse Comics' most popular character. A few fans responded with nostalgia for Ron Perlman's take on the character. Unfortunately, Harbour's original tweet has since been deleted, but we managed to acquire a screenshot of it before it was removed. When a new Hellboy movie was first announced earlier this year , many fans were disappointed it would not be Guillermo del Toro's ... Read More »
Liam Neeson says he's done in action movies after 'Mark Felt'
Liam Neeson will turn in his title of action hero in the near future. Liam Nesson has already shot two new movies but he said he is done with action roles. The movie got its premiere at the Toronto International Film Festival on Monday. In it, he plays the high-ranking Federal Bureau of Investigation official who was the Washington Post's " Deep Throat " source in the scandal. Read More »
Mike Myers Reportedly Cast in 'Bohemian Rhapsody' Biopic
Having left the film Del , a film about Del Close, the coach and mentor of numerous Hollywood stars, which has been put on hold for financial reasons, Mike Myers may be about to join the cast of another biopic. But after what seemed like a nasty fall out, Cohen walked away from the role and stated in a radio conversation that "no one is going to see a movie where the lead character dies of AIDS and the band carries on". Read More »
In the waters of Singapore has faced ships: 5 sailors missing
The dredger was transiting in the westbound lane of the traffic separation scheme (TSS) when it was involved in a collision with the Indonesian-registered tanker Kartika Segara which was joining the eastbound lane of the TSS. According to the MPA, the dredger capsized as a result of the accident and is now partially submerged. Divers recovered the two bodies from the partially submerged dredger, the Maritime and Port Authority of Singapore said. Read More »
Lady Gaga's Upcoming Documentary Shows What It's Like to Live With Fibromyalgia
Yesterday, Gaga revealed the name of her condition: fibromyalgia , an incurable disorder that causes widespread pain. "Me and Taylor are fighting, so that sucks". "I sold 10 million [records] and lost Matt [her ex]". I sold 30 million and lost Luc [a DJ and her boyfriend of six years ]. I did a movie and lose Taylor. Read More »
Rihanna Takes Highlighter to the Next Level on the Fenty Runway
But in true Rihanna style she made sure she didn't follow the trend and added her own unique touch to her line, which saw her introduce "pinky nude" coloured blotting sheets to add a touch of sexiness to her collection. One (totally BS) defense by certain beauty brands as to why their foundation shade range isn't more inclusive is that they claim darker shades won't sell. Read More »
Angelina Jolie's kids are her best friends
According to Angelina , the Jolie-Pitt kids have been "itching to get out in the world again" after being "a bit in lockdown" following the divorce. "It's very, very hard, a very painful situation, and I just want my family healthy", the Maleficent star said during an interview with The New York Times , adding, "They're getting better". Read More »
Syracuse University's George Saunders makes prestigious 'Man Booker' shortlist
A 29-year-old debut novelist has been shortlisted for this year's Man Booker Prize for a book she began writing on her mobile phone on her way to work. The list also features 2 debut novelists, one each from the U.S. and the UK. The British author and travel writer, who was longlisted for the award in 2002, said some blurbs "almost blackmail" readers into believing it is their fault if they don't enjoy a novel. Read More »
Hulk Hogan Reacts To Kevin Owens Attacking Vince McMahon
After it was announced that Kevin will face Shane inside Hell in a Cell next month, Owens asked Vince that he could 'beat a McMahon senseless if provoked'. The match should be all about "making" Owens, not giving Shane O'Mac his first pay-per-view singles victory since he returned to WWE in early 2016. Read More »
USA to face one of the most risky hurricanes ever
As of 6 a.m., over 5.7 million customers were without power in Florida - that's roughly 58 per cent of all customers in the state. At least three people in the state were killed by the storm. The storm was weakening, but still potent, as it traveled northward through Georgia and SC. With forecasts Friday shifting Irma away from the state's coastline, McMaster still hadn't made a decision on whether evacuations were needed. Read More »
Helicopter crash that killed Troy Gentry caused by faulty engine
The report says the pilot, 1000 feet up, chose to perform an emergency procedure called an autorotation - in which the rotor turns from upward airflow, without the engine. Check back for more details from the report . Gentry was still alive when rescue workers cut him from the wreckage, but he died a short time later at Virtua Hospital Marlton. Read More »
J. Law 'horrified and shocked' by Luann and Tom's divorce
Page Six reported they even came to blows earlier this summer, when de Lesseps, 52, reportedly slapped her husband at a NY eatery. Oscar-winning actress Jennifer Lawrence has made no secret of the fact that she is a Bravo superfan, especially when it comes to the Real Housewives franchise. Read More »


text: HELLO! Welcome to my business page where you will get a little bit of biz talk and a lot of real life with me, my rockstar hubs and 7 amazing kids! I have a tendancy to over share ...you have been warned! I love diet coke, running, fashion, crossfit, chocolate and the beach. At pretty much anytime I can be persuaded to workout or drop all my responsibilities and head to the beach! Oh, yeah- I also sell LuLaRoe in the form of a traveling gutted shuttle bus! Click the notifications button and stay in the loop with all my crazy! Want to book a party? Yup, I do that too!


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"When my family decided to spend the holidays in California, we never imagined that the rented van that we were traveling in from Disneyland to Northern California would be struck by a runaway 18-wheeler truck. Being overseas residents, we asked our close friends and business colleagues for California attorney recommendations. We interviewed many attorneys but chose attorney Joel H. Siegal from a long list of California litigation attorneys. Joel is intelligent, aggressive, responsive and compassionate. We could not have asked for more effective and professional legal counsel."
— Fernando Cojuangco, Manila, Philippines
Result: The case was settled for $5 million.
"Joel is a great attorney but is also very personable. He cares about his clients getting to know them as individuals and their families. You are not a 'case' with Joel, you are a person and a friend. Joel is also very creative and leaves no stone unturned resulting in some sizable settlements. I recommended several friends to Joel and they all raved about him. If you had some misfortune, I highly recommend Joel."
— Thomas Kereszti, San Francisco, California
"Mr. Joel Siegal helped me resolve several significant legal issues with individuals, and with both small and big companies that I was involved with. More importantly, Joel provided me with smart advice on how to manage each of the legal issues. Joel explained to me the risks and potential benefits from taking different legal routes. Together we set strategies to manage the legal issues. In all cases, Joel Siegal was able to resolve all issues with results that exceeded my expectations. Previously I had experience with big firms, however, dealing with Joel directly was refreshing, successful, efficient and economically beneficial."
— Eitan Cadouri, Startup Executive, Silicon Valley
"I worked as a law clerk for Joel for seven months beginning with the summer after my first year of law school. I learned a great deal about the law from working with Joel, but I learned more about how to be a great lawyer. Joel's professionalism and commitment to achieving the best result possible for his clients was evident every day in the office. In the practice areas that Joel works, generally the lawsuits result from an unfortunate incident that has a huge impact on the client's life. Thus, it is important to find a lawyer who you can trust and who has your best interests in mind. Joel absolutely fills these needs. He does an excellent job of making sure his clients are aware of where the cases are in the litigation process. He keeps the clients involved and informed, but at the same time makes the process very easy for his clients. His experience and wealth of knowledge in all areas of the law are impressive. I was also surprised at how efficiently he was able to balance complex and large numbers of cases as a solo attorney. I would absolutely recommend Joel if you are looking for an attorney in the SF Bay Area."
— Payam Saljoughian, San Francisco, California
"Joel's passion for justice was very apparent when he represented our family during our personal injury case. His follow up was prompt and thorough which was always reassuring during this process. We felt Joel kept us informed and prepared throughout the legal process without making us feel overwhelmed. We felt like Joel was feeling our pain and was looking out for us. Additionally, his choice of subject experts proved effective."
— John and Susan, Seattle, Washington
"Joel is an amazing professional. His domain expertise makes you feel at ease about your case by answering all your questions thoroughly. He is also very efficient, responsive and personable. I have referred at least six people to Joel, and everyone has been very happy. I also have a number of friends who use Joel, and we all agree that he is highly professional, intelligent, affordable, and gets the job done. If you are looking for an outstanding attorney with an exceptional track record — you found the right guy!"
— Sharone M., Palo Alto, California
"I have known Mr. Joel Siegal for a year through my professional network. Just recently, I needed some straightforward advice regarding an unexpected legal matter. Not only did Joel respond to my request within hours, he provided the honest feedback I sought to make an informed decision about my situation. He knew just the right questions to ask to quickly assess the facts of the matter and provide me with the best course of action. He is a consummate professional who looks out for your best interests. If you are looking for someone you can trust in a time of difficulty and uncertainty, call or email Joel Siegal today."
— Karen C., Novato, California
"I can testify that Joel Siegal is a smart, take-charge, combative — yet compassionate — attorney. He gives his full commitment to you, providing excellent advice and working hard to get justice. When hiring an attorney, consider the fact you will be spending a good deal of time with that person, so it's important to have an attorney whom you like, get along with, as well as respect. That would be Joel."
— Todd C., San Rafael, California


text:
This site is dedicated to all things Jack the Ripper: book reviews, movie reviews, and my thoughts about the case in general – from the suspects, to my opinions about the canonical five. I've been a life-long Ripperologist ever since watching the 1988 mini-series starring Michael Caine when I was ten years old, and have been researching the infamous Whitechapel murders for over twenty years. So whether you're a hard-core Ripperologist, or just have a casual interest in the case, I hope you'll find something of interest here.
–Brett McBean


text:
Joshua Hill
- Arrest Number: 9704
- First Name: Joshua
- Last Name: Hill
- Middle Name: Francis
- Current Age: 20
- Booking Date: 2017-09-14 15:00
- Race: I
- Sex: M
- Arresting Agency: Us Marshal
- Arrest Date: 09/14/2017
- City: Superior
- State: Wisconsin
booking information
Joshua Hill was booked on 2017-09-14 15:00. Hill was arrested by Us Marshal in Superior, Wisconsin. Hill was 20 years old at the time of the arrest.
Joshua Hill may not have been convicted of the charges or crimes listed and are presumed innocent until proven guilty. Please contact the Us Marshal for more information regarding arrest records.
We are not affiliated with the Us Marshal and we cannot make any claims as to the validity of the records provided by them.


text:
What is a weblog?
News about nature and the environment in Singapore - Archives
List of Categories : errata * about * map * cycling * events * marine * animalwelfare * envt * jobs * research * talks * photos * coastalcleanup * news * education * cameratraps * tvradio * internet * software * nature * malaysia * books * heritage * trade * stamps * articles * parliament * conceptplan * world *
Thu 18 Jan 2007
"The Importance of Bukit Timah as a Fungus Sanctuary"
Category : talks
"The Importance of Bukit Timah as a Fungus Sanctuary"
By Prof. Roy Watling
Sat 20 Jan 2007: 4pm - 5.30pm
Bukit Timah Nature Reserve: Visitor Centre meeting room
Hosted by The Center for Tropical Forest Science - Arnold Arboretum Asia Programme.
About the talk - Fungi are the source of materials used in medicine, industry and everyday activities including baking, brewing etc.
Fungi also are the important nutrient cyclers of the world and are important in very special and intimate associations with other organisms which make the natural world function.
A few are also parasites of plants and animals including humans but these are small in proportion compared with those which benefit and are fundamental to natural ecosystems, and therefore benefit mankind.
Fungi must be described, defined and named so that researchers can communicate and a natural order of relationships within our natural heritage achieved. It will be shown how Bukit Timah is paramount in achieving this aim.
About the speaker - Prof Roy Watling, BSc, DSc, FRSE, FIBiol, C.Biol., MBE, was former head of the Mycology and Plant Pathology section at the Royal Botanic Garden, Edinburgh. His research interests are particularly in the ecology and systematics of larger fungi, and although his earlier work centred on artic-alpine fungi, he has become more and more concerned with tropical fungi, especially ectomycorrhizas of Caesalpinoid legumes in North Africa and of dipterocarps in South East Asia.
Prof Watling has traveled widely in the course of his research, including Australia, India, West and Central Africa, S.E.Asia (Malaysia and Thailand) and extensively in North America and northern Europe. He has authored and co-authored over 100 scientific papers, reviews and reports and has spawned several books both for the amateur and the professional. A recent book (Children and Toxic Fungi) is a paediatricians guide to the most likely species of fungi children may pick up in gardens and public places.
Roy is a member of the UK Systematics Forum, an Honorary Reader at the University of Aberdeen and a corresponding member of several mycological societies. He is a Past President of the British Mycological Society, the Botanical Society of Scotland and the Yorkshire Naturalists Union.
His recent projects include the identification and ecology of larger fungi in the Korup rainforest reserve in Western Cameroon, the boletes of various forest reserves in western Zambia, and the wood-rotting and ectomycorrhizal basidiomycetes of lowland dipterocarp rainforest in Peninsular Malaysia. He is also currently involved in an EC programme joint with Kent University on the identification and culture of basidiomycetes from the Philippines.
Thanks to Siew Chin, CTFS-AA, for the alert


text:
Some give us birth, some give us children, but it's gypsy women in the night who adorn our male bruises with tattoos.
Why I'm Telling You This
I've always thought that organizing and re-organizing books is a pretty good metaphor for life itself. Remember the first time you did it—placing the large picture books on one end and the smaller ones, like Beatrix Potter, on the other. As we grow older we keep only those that still hold a piece of ourselves and add others full of mystery (like the Hardy Boys or Nancy Drew), adventure (Call of the Wild) and even young romance (and here I have to defer to my wife's Anne of Green Gables). Words replace pictures as we travel back in time or forward out into space. "Once a reader, always a reader," proclaims the masthead of a pulp magazine from the '20s.
Then the day comes when we merge our personal collection with that of another. Over the years these books weather moves, suffer damage from mildew in basements or are even lost when we lend some to friends who don't return them. When that happens we feel it more personally than a missing casserole dish. A book can be replaced, but for sentimental reasons we seldom do it. And perhaps that's how love is lost, for inevitably the day comes when we must separate what is ours from what is hers (or his), decide what is me and what is, after all, someone else.
Perhaps you have a book that once belonged to your mother or father. For me it is one called How to Draw Anything. My dad, who was an aspiring painter, prized it and referred to it often. Don't we secretly hope that someday after we are dead one of our children or one of our friends will hold a book that was part of us and take it home, make it live on in his or her life? But, that's not why I'm telling you this. There's more to sharing our stories than books.
This happened to me twenty years ago. I had been fortunate to have a half- dozen poems published over a period of a year and a half. My nephew who was an adult living in Chicago heard about this and asked me to send him some of my poetry. I xeroxed a number of poems and sent them off. A month later he wrote that he'd enjoyed them well enough, but that he was very surprised when his mother (my sister) came over one night and spent a couple hours in an easy chair reading them…one in particular. I instantly knew which poem this was.
When I was about fourteen my sister and her husband were expecting their third child. They had decided to name it "John" if it were a boy. At that age I took this to mean they were naming the baby after me. The baby was born, right before Christmas. It was a boy. Unfortunately it lived for only a few days, then died. Everyone gathered at my parents' home for Christmas Eve. Ordinarily my sister who was sixteen years older than me, would have been in the middle of the celebration, she was very gregarious. That night she didn't feel like it so she sat in an easy chair in my room as I worked on a model railroad building. I didn't know what to say. I still wouldn't; but years later when I wrote a poem called "Autobiography" it was this experience that was one of its central images. And now years later, through writing, my feelings expressed in that poem reached her. No publication in a magazine could possibly compare to that.
Several years after my nephew's note, I invited my sister to participate in one of my writing seminars. She had been a journalist and I thought it might get her writing again. When it came to the point where I talk about showing your work to others and trying to get publishing, I thought to myself, Should I include this anecdote I usually told about this autobiographic poem. My sister and I had never discussed her child's death directly. Well, I decided to go ahead and recount the story. When I finished all eyes turned to her, they knew she was my sister. She said, "You know, it wasn't that you didn't say anything, the trouble was that no one said anything." I was so happy she had seen that poem. That she knew we did care, even if we couldn't say it. Later in the year, at another seminar, a woman called out, "My God, I had a baby, named John, who died and no one would talk about it either."
We're all friends,…who just don't know each other. Sharing our stories is a way in which we do. Thank you for coming tonight and listening to mine. I hope they remind you of some of your own stories that you might otherwise have forgotten. Stories you make your own, that you can tell others. Little scenes with a direction and meaning, at least for you; in which you take risks that test the boundaries of who you are. In some mysterious way stories and poems, yours and mine, help us to understand our world and guide us forward. Perhaps they are, after all, the handouts for a satisfying life that we though we never got.
Slowly at first, then with gusto
And remember…All you need are suds, suds, suds are all you need. All you need are suds (all together now). All you need are suds (every- body). All you need are suds, suds, suds are all you need."
Darkness, then the lights come up on an empty stage. John enters from stage right, bows and waves good-night.
If Poets Did Useful Things
It's dark. People need to be places,
yet the Poet Transportation Authority
busses lurch, wild-eyed and empty,
down half-deserted streets, drivers
muttering, " And miles to go before I
sleep. And miles to go before I sleep."


text:
Commercial Lending Team
First City Bank offers a variety of loan products and financing to meet the unique needs of our business customers. Contact one of our lenders today, so we can customize a finance plan for you.
Herb Tinsley
Executive Vice President, Senior Lender
Commercial Lending
E-mail Herb
Kevin Johnson
Senior Vice President
Commercial & Construction Lending
E-mail Kevin
Steve Caldarelli
Senior Vice President
Commercial Lending & Special Assets
E-mail Steve


text:
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List of Colleges in India - Search by Category
Search Indian colleges by types Medical, Nursing, Law, Engineering, B.Ed, MBA, Arts and Science, Distance Education, Hotel management, University colleges and other colleges at one place here. You can search by state-wise category listed in Indiastudychannel. You also search by specific course. All the Indian
Colleges are listed here. So no problem for finding your expected college.
Colleges are listed here. So no problem for finding your expected college.
- Medical
- Nursing
- Law
- Engineering
- B.Ed
- Arts and Science
- Distance Education
- Hotel management
- University colleges and other college
Here are the list of colleges in India.
Click the below link and see the bottom page of the post to search the college details.


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Other Resources:
AFD Cell Phone Policy
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New Cell Phone Reimbursement Policy Information
This policy outlines a procedure for cell phone use by AFD employees in the performance of their duties.
Cal Poly Administration and Finance 2011 Performance Metrics
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Protected Disclosure of Improper Governmental Activities Procedure
Protected Disclosure of Improper Governmental Activities Form
The Associate Vice President for Administration has been designated to receive formal Whistleblower complaints (Allegations of Government Misconduct) from employees and applicants for employment on the campus. Campus procedures and the filing form may be accessed here.
Complaint of Retaliation for Reporting Improper Governmental Activities
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Complaints of retaliation for having filed an allegation of government misconduct are to be filed with the Associate Vice President for Administration. Procedures for filing a retaliation complaint and the filing form may be accessed here.
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|Procedure for requesting University-Wide Charitable fundraising approval


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The Structural Engineer
Volume 54 (1976)
Issue 9
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A letter from a contributor to this column complains that he has received neither acknowledgement nor reply to an earlier letter; oontributors should understand that generally we will not do so, for the two simple reasons that it would cost money and take up time better applied in doing something else. Inclusion of comments in the column suffices when this is done, but readers will recollect that we reserved the right to edit, mutilate (in the belief of the contributor) or ignore comments as we saw fit. This particular comment had, in fact, been used in the copy some time before the complaint was received but there is necessarily a quite considerable lapse of time between preparation of the column and actual publication. Moreover, contributors are not dealt with strictly in the chronological order they are received; some effort is made to achieve a continuity and balance. This may not be well done but is at least attempted. In writing about the column itself we would also remind contributors that they should express their comments as concisely as possible. Most do but we have received several which would fill half a dozen or more pages of the journal and the task of condensing some of these can, and does, lead them to being set aside for next month-a process which tends to be repeated indefinitely! Verulam
The Institution of Structural Engineers, 47-58 Bastwick Street, London, EC1V 3PS, United Kingdom
Tel: +44 (0)20 7235 4535
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Download E-books Aristophanes: the Complete Plays PDF
By Aristophanes
A brand-new translation of the world's maximum satirist.
With a signature variety that's without delay bawdy and gentle, in addition to a fearless penchant for lampooning the wealthy and strong, Aristophanes continues to be arguably the best satirist of all time. amassed listed here are all eleven of his surviving plays-newly translated by means of the prestigious poet and translator Paul Roche.
Download E-books Ancient Greek Athletics PDF
By Stephen G. Miller
The earliest Olympic video games begun greater than twenty-five-hundred years in the past. What have been they prefer, how have been they organised, who participated? have been old activities a way of getting ready adolescence for struggle? during this lavishly illustrated e-book, a global specialist on old Greek athletics presents the 1st complete advent to the topic, vividly describing historic sporting activities and video games and exploring their impression on paintings, literature, and politics. utilizing a big selection of historical assets, written and visible, and together with fresh archaeological discoveries, Stephen Miller reconstructs historical Greek athletic gala's and the info of particular athletic occasions. He additionally explores broader issues, together with the position of ladies in old athletics, where of amateurism, and the connection among athletic occasions and social and political existence. released within the yr the fashionable Olympic video games go back to Athens, this ebook might be a resource of data and delight for an individual attracted to the background of athletics and the origins of the world's most renowned carrying occasion.
Download E-books From Plato to Platonism PDF
By Lloyd P. Gerson
Was Plato a Platonist? whereas historic disciples of Plato could have spoke back this query within the affirmative, sleek students have ordinarily denied that Plato's personal philosophy used to be in significant contract with that of the Platonists of succeeding centuries. In From Plato to Platonism, Lloyd P. Gerson argues that the ancients have been right of their overview. He arrives at this end in an extremely creative demeanour, not easy primary assumptions approximately how Plato's teachings have turn out to be understood. via deft readings of the philosophical rules present in Plato's dialogues and within the Platonic culture starting with Aristotle, he indicates that Platonism, extensively conceived, is the polar contrary of naturalism and that the historical past of philosophy from Plato until eventually the 17th century was once the historical past of varied efforts to discover the main constant and whole model of "anti-naturalism."
Gerson contends that the philosophical place of Plato―Plato's personal Platonism, with the intention to speak―was produced out of a matrix he calls "Ur-Platonism." in accordance with Gerson, Ur-Platonism is the conjunction of 5 "antis" that during overall arrive at anti-naturalism: anti-nominalism, anti-mechanism, anti-materialism, anti-relativism, and anti-skepticism. Plato's Platonism is an try to build the main constant and defensible confident procedure uniting the 5 "antis." it's also the approach that every one later Platonists all through Antiquity attributed to Plato whilst countering assaults from critics together with Peripatetics, Stoics, and Sceptics. In end, Gerson indicates that overdue vintage philosophers similar to Proclus have been correct in concerning Plotinus as "the nice exegete of the Platonic revelation."
Download E-books La Cité grecque PDF
By Gustave Glotz
Avec l. a. Cité vintage de Fustel de Coulanges, l. a. Cité grecque de Gustave Glotz reste l'un des plus importants ouvrages écrits sur los angeles société vintage. Cette superbe synthèse où sont pris en compte aussi bien les faits sociaux que les faits religieux, los angeles psychologie des individus comme les buildings économiques, a marqué d'un sceau indélébile notre snapshot de l. a. "cité grecque".
Écrit à l. a. fin des années 1920, à une époque où l. a. démocratie était attaquée par l'idéologie totalitaire, l. a. Cité grecque est un témoignage irremplaçable sur l'école politique de l'humanité qu'a été l'Athènes des Ve et IVe siècles. En voulant faire une histoire totale dépassant le easy alignement des faits, en questionnant le passé à l'aune du présent, Gustave Glotz reste ainsi un de nos maîtres à penser.
Download E-books Aeschines (The Oratory of Classical Greece, Vol. 3; Michael Gagarin, PDF
This is the 3rd quantity within the Oratory of Classical Greece sequence. deliberate for booklet over a number of years, the sequence will current all the surviving speeches from the past due 5th and fourth centuries B.C. in new translations ready via classical students who're on the vanguard of the self-discipline. those translations are specifically designed for the desires and pursuits of brand new undergraduates, Greekless students in different disciplines, and the final public.
Classical oratory is a useful source for the examine of historical Greek existence and tradition. The speeches provide proof on Greek ethical perspectives, social and monetary stipulations, political and social ideology, and different facets of Athenian tradition which were mostly missed: ladies and kinfolk lifestyles, slavery, and faith, to call only a few.
This quantity includes the 3 surviving speeches of Aeschines (390-? B.C.). His speeches all revolve round political advancements in Athens through the moment half the fourth century B.C. and replicate the inner political rivalries in an Athens overshadowed by way of the starting to be strength of Macedonia within the north. the 1st speech used to be added while Aeschines effectively prosecuted Timarchus, a political opponent, for having allegedly prostituted himself as a tender guy. the opposite speeches have been introduced within the context of Aeschines' long-running political feud with Demosthenes. As a gaggle, the speeches offer vital info on Athenian legislations and politics, Demosthenes and his profession, sexuality and social background, and the historic competition among Athens and Macedonia.
Download E-books A Commentary on the Homeric Hymn to Hermes: Introduction, Text and Commentary (Texte und Kommentare, Band 41) PDF
By Athanassios Vergados
First-class variation. because of unique uploader. e-book retails at $182. hardcover retails at $182. whatever has to provide in educational publishing!
Aims and Scope
The Hymn to Hermes, whereas without doubt the main a laugh of the so-called Homeric Hymns, additionally provides an array of not easy difficulties. in exactly 580 traces, the infant god invents the lyre and sings a hymn to himself, travels from Cyllene to Pieria to thieve Apollo's farm animals, organizes a dinner party on the river Alpheios the place he serves the beef of 2 of the stolen animals, cunningly defends his innocence, and is eventually reconciled to Apollo, to whom he offers the lyre in trade for the livestock. This e-book offers the 1st unique statement committed in particular to this strange poem on the grounds that Radermacher's 1931 version. The observation will pay targeted consciousness to linguistic, philological, and interpretive concerns. it's preceded via an in depth creation that addresses the Hymn's principles on poetry and tune, the poem's humour, the Hymn's relation to different archaic hexameter literature either in thematic and technical elements, the poem's reception in later literature, its constitution, the difficulty of its date and position of composition, and the query of its transmission. The severe textual content, in keeping with F. Càssola's version, is supplied with an gear of formulaic parallels in archaic hexameter poetry in addition to attainable verbal echoes in later literature.
Athanassios Vergados, Ruprecht-Karls-Universität Heidelberg, Germany, andNational and Kapodistrian college of Athens, Greece.
xiv, 718 pages
Language: English, historic Greek
Type of book: Commentary
Keywords: Homeric Hymns; Hermes; Poetry; Greek; faith
Download E-books Ancient Literacies: The Culture of Reading in Greece and Rome PDF
Contemporary advances in cognitive psychology, socio-linguistics, and socio-anthropology are revolutionizing our knowing of literacy. even though, this learn has made basically minimum inroads between classicists. In flip, historians of literacy proceed to depend upon outmoded paintings through classicists (mostly from the 1960's and 1970's) and feature little entry to the present reexamination of the traditional facts. This well timed quantity seeks to formulate fascinating new methods of conceiving the total thought of literacy within the historical international, as text-oriented occasions embedded specifically socio-cultural contexts.
In the quantity, chosen major students reconsider from the floor up how scholars of classical antiquity may possibly most sensible procedure the query of literacy long ago, and the way that research may possibly materially intersect with adjustments within the approach that literacy is now seen in different disciplines. the outcome will provide readers new methods of pondering particular parts of "literacy" in antiquity, equivalent to the character of non-public libraries, or what it capacity to be a bookseller in antiquity; new constructionist questions, akin to what constitutes analyzing groups and the way they style themselves; new takes at the public sphere, comparable to how literacy intersects with commercialism, or with using public areas, or with the development of civic identification; new essentialist questions, akin to what do "book" and "reading" symbolize in antiquity, why literate cultures improve, or why literate cultures topic.
Containing new paintings from trendy impressive students of literacy in antiquity, Ancient Literacies could be an necessary assortment for all scholars and students of analyzing cultures within the classical world.
Download E-books Historical Dictionary of Ancient Greek Philosophy (Historical Dictionaries of Religions, Philosophies, and Movements Series) PDF
The old Greeks weren't simply the founders of western philosophy, however the real time period "philosophy" is Greek in starting place, probably courting again to the past due 6th century BC. Socrates, Plato, Aristotle, Pythagoras, Euclid, and Thales are yet many of the better-known philosophers of historic Greece. in the course of the amazingly fertile interval working from approximately the center of the 1st millennium BC to the center of the 1st millennium advert, the realm observed the increase of technological know-how, various colleges of concept, and—many believe—the beginning of contemporary civilization.
This moment variation of Historical Dictionary of historical Greek Philosophy covers the background of Greek philosophy via a chronology, an introductory essay, a thesaurus, and an intensive bibliography. The dictionary part has over 1500 cross-referenced entries on vital philosophers, techniques, concerns, and occasions. This e-book is a wonderful entry element for college students, researchers, and someone desirous to comprehend extra approximately Greek philosophy.
Download E-books Language and Logos: Studies in Ancient Greek Philosophy Presented to G. E. L. Owen PDF
The essays during this quantity have been written to have a good time the 60th birthday of G. E. L. Owen, who via his essays and seminars on historical Greek philosophy has made a contribution to its learn that's moment to none. The authors, from either side of the Atlantic, contain not just students whose major study pursuits lie in Greek philosophy, yet others most sensible recognized for his or her paintings often philosophy. All are scholars or more youthful colleagues of Professor Owen who're indebted to his perform of philosophical scholarship as a first-order philosophical job. on the middle of G. E. L. Owen's paintings has been a preoccupation with the function of philosophical mirrored image on language within the metaphysics and epistemology of Plato, Aristotle and different old Greek thinkers. this is often consequently the final subject of the current quantity, inclusive of 5 papers on Plato's severe dialogues and 7 on Aristotle, prefaced by means of on Heraclitus and by way of a research of the controversy in Hellenistic philosophy at the sorites. this can be a e-book for experts in Greek philosophy and philosophers of language so one can even be of curiosity to a few linguists.
Download E-books Oaths and Swearing in Ancient Greece (Beitr GE Zur Altertumskunde) PDF
The oath was once an establishment of primary significance throughout quite a lot of social interactions during the historical Greek international, creating a the most important contribution to social balance and concord; but there was no entire, devoted scholarly examine of the topic for over a century. This quantity of a two-volume learn explores the character of oaths as Greeks perceived it, the ways that they have been used (and occasionally abused) in Greek existence and literature, and their inherent binding power.


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This time we headed north.
The first nursery we visited was the furthest away - almost an hour. We intended slowly making our way back visiting nurseries on the way.
I fell I love with the first nursery. Rosemount nursery is near Bli Bli . The first thing we noticed (near the car park) was their pots - a huge variety at really good prices. From that moment I knew I'd be coming back.
Then we discovered the plants. They were all so healthy and well tended.
Their "tropical" area was huge. This is only a small part. I could picture quite a few living in our garden.
But we were on a fact-finding mission - no buying today.... so we kept going.
We visited three more nurseries in the Buderim area before we stopped for lunch.
This vertical garden gave me some ideas. It's simply pots of geraniums so would be reasonably easy to care for.
The other nurseries were OK but over lunch I kept thinking of the first one and we both agreed it was one of the best we'd seen, so you can guess what happened next.
We doubled back.
We filled the car.
We came home.
The haul - 3 Bangalow Palms, 3 cardboard cycads Zamia furfuracea, 2 pots of tiger grass Thysanolaena maxima, 2 dracaena tricolour and a Cousin It Casuarina glauca.
I guess we'll have to go back and check the rest out another time - and visit the Yandina Markets which I've been told has great plants for sale. Next time we'll take a bigger car and maybe the trailer.


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The City of Montréal received the 2017 Smart Cities Award from FIA (Fédération internationale de l'automobile) during the Smart Cities Forum, organized alongside the first Formula E race in the city.
The award, presented to the most innovative city in recognition of its smart and sustainable mobility solutions, celebrates the ambitious projects rolled out by the City of Montréal over the past few years, including the 2016–2020 Transportation Electrification Strategy, the CGMU (urban mobility management centre) and the city's commitment to road safety by adopting the "Vision Zero" strategy.
Montréal wants to become the North American leader in transportation electrification and sustainable mobility by 2020. Creating an institute for electrification and smart transportation is one step in that direction. The institute will leverage Montréal's transportation and AI expertise, which is key to developing autonomous vehicle technologies and more.
The electric vehicle (EV) industry is experiencing sustained growth in Québec and employs 3,000 workers in about 40 companies and 30 specialized research centres. The creation of an EV industry cluster earlier this year will no doubt strengthen Montréal's role as a key enabler of sustainable mobility and a connected community of the future.
Greater Montréal has also made a name for itself as the world leader in AI and big data, as recently mentioned in Fortune magazine. With the largest number of academic researchers in deep learning and a raft of major public and private investments, the area has all the cards stacked in its favour to see intelligent transportation and sustainable mobility flourish.
Google, known for developing a self-driving car, has recently chosen Montréal as the home base for a new AI research group that will be headed by Hugo Larochelle and will be working with Montréal universities. The company will be investing $4.5 million over three years.
In addition to being praised for its visionary projects in the area of transportation systems, Montréal was also named Intelligent Community of the Year in 2016 by the Intelligent Community Forum, in recognition of its innovative use of information and communications technologies to create economic prosperity, address social issues and enhance quality of life, in part by improving transportation and mobility.
The transportation industry is experiencing a dramatic shift and Greater Montréal plans to play a pivotal role in the process by showcasing its leading-edge industries, expertise and ability to innovate.


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This book is both exactly what you'd expect from the cover — and totally different. A heartwarming tale of friendship and loyalty and persistence, with a surprising and subversive twist. A book of few words, but tons of fun to read aloud. A color palette that remains constant even as the story takes an unexpected turn. A picture book for the very, very young, but one that employs panels and other conventions of comics and graphic novels.
Author-illustrator Kevin Henkes is no stranger to Caldecott recognition: the 2005 Medal for Kitten's First Full Moon; Caldecott Honors for Owen (in 1994) and just last year for Waiting. I can't imagine that this newest book, which was published by Greenwillow in January, isn't already on Caldecott committee members' radars.
Here, for now, is the Horn Book Magazine review of Egg; look for more about this latest Henkes masterpiece come fall.