text:
By: Sports Information Director, Luke Pattarozzi
ROCKFORD, Ill. (SabreAthletics.com) – Sophomore Cody Veleke scores a career-high 31 points and the Marian University men's basketball team shoots 55.6 percent for the game, but it's not enough as host Rockford College nets a decisive free throw with 2.6 seconds left to get the, 85-84, win on its home floor, today, Dec. 3.
Veleke was nearly perfect from the floor, going 14-for-15 from the field, 2-of-4 from the free throw line and knocking down his only three-point attempt for a game-high 31 points in 33 minutes of action. Junior Jeff Harris scored 19 points and Mike Keller added 12 for Marian. The Regents, who shot 52.4 percent as a team, were led by Tory Minnifield's 27 points on 11-for-19 from the field. He scored scored 20 of those in the second half alone.
Rockford improves to 3-3 overall, 1-1 in the NAC, while the Sabres fall to 2-4 (0-2 NAC).
Trailing 84-80 with 45 seconds left to play, the Sabres and Interim Head Coach Tony Draves called a timeout to set up the ensuing comeback. Out of the break, it looked to have backfired as the Sabres turned the ball over, but Mike Keller returned the favor as he stole it away from Rockford's Darryl Watkins and laid it in to pull MU to within a bucket.
After a foul and missed Regent free throw, the Sabres got the ball back and Veleke tied it up with 15 seconds remaining.
With the clock down to six seconds, Rockford's Danny Fair missed a jumper that caromed right to Minnifield, who was then fouled on a shot attempt by Keller with just 2.6 seconds remaining. Minnifield missed the first free throw before burying the second. Marian got nothing more than a desperation heave that went for naught.
The Sabres did nearly everything they could offensively, shooting 60 percent in the second half, but Rockford went 50 percent from the field in their own right.
MU trailed 47-42 at halftime, getting 16 points from Veleke and nine from Harris. Both teams shot over 51.5 percent from the floor.
The Sabres recorded 22 assists on 35 baskets in the loss. Seven players recorded multiple assists, including Charles Ruffing, who tallied a team-high five off the bench.
The Sabres will host Concordia Wisconsin on Wednesday, Dec. 7, next time out. Tip-off is slated for 7:30 p.m. inside Sadoff Gymnasium.
Comments are closed.
Championships (11)
(78-79), (79-80), (80-81), (82-83), (83-84),
(87-88), (89-90), (90-91), (98-99), (99-00),
NCAA Tournaments (2)
(00-01), (13-14)
April 2018


text:
|Out of season FAQsCleaner seasCommunity blogBeachWise
Even cleaner seas for Combe Martin
A £2million scheme to deliver even cleaner seas off Combe Martin, which started in September 2014, has been successfully completed in time for the start of the official bathing water season.
To improve bathing water quality at Combe Martin, South West Water has constructed a 325 cubic metre underground storage tank in the parish council coach park and a 300 cubic metre underground storage tank in the Glen Lyn car park.
The additional storm water storage capacity in the sewerage network and other improvements will reduce the number of storm discharges into the River Umber during extremely wet weather.
Senior Project Manager Mike Court said: "In total, the work represents a £2million investment in bathing water quality in the area, which will benefit the tourism industry in Combe Martin.
"We believe that, with the help of the local community, this major investment will help deliver even cleaner seas for Combe Martin, in time for the new European bathing water standards.
"The Combe Martin Clean Bathing Water Group and the Environment Agency are also working hard to improve bathing water quality.
"You can help by checking your property is correctly connected to the foul drainage system - investigations by the Environment Agency and South West Water have identified that homes with plumbing that is incorrectly connected into the surface water system are a source of faecal pollution to some of the bathing waters in the South West.
"Some drains lead directly to rivers and beaches, so please don't pour paints, oils or chemicals down them. Nappies, wipes, cotton buds, fat, oil and food waste can all block drains and cause pollution so please dispose of them correctly."
For more information see www.southwestwater.co.uk/evencleanerseas.
Notes for editors
Published: 1 May 2015
For further information please contact:
Press Office
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subset: commoncrawl


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If asked to name some Swiss design labels, what would your answer be? Perhaps a prestigious watch brand, a cool and functional furniture designer or maybe you read about Akris in a fashion magazine? Let me share some exciting new names, fashion collaberations and collections I spotted at the twelth edition of Mode Suisse with you!
Ladina Steinegger
Based in Rome, Ladina Steineggers` bright, geometric designs can also be found in collections at Balenciaga, Givenchy and Lanvin. I loved her use of strong colours and print, a collection, which can seamlessly move from the catwalk into your closet.
Worn by names such as Taylor Swift, Katy Perry and Kirsten Stewart. Yvy blurs the boundaries between traditional accessories and clothing, transforming the simplist outfit into an exquisite look. Each piece is hand made by designer Yvonne Reichmuth and her team here in Zürich.
Kévin Germanier
A wild and colourful debut collection that lit up the catwalk! Kévin Germanier studied at London`s central St Martins, focusing his studies on important fashion-forward themes such as sustainability and design responsibility. He has recently been snapped up to work for Louis Vuitton as a junior designer.
En Soie and Julian Zigerli showcased their first capsule collection "eSJZ" with a see now – buy now concept. You could even buy personal favourites after the show directly from the designers themselves. The collection, presented in pairs consisted mainly of day to day functional pieces.
Thank you Mode Suisse for having me and for supplying the photographs from the fashion show!
Photographs: Boris Marberg


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Slow Design in three steps
Guest blog by Susanna Cots Estudi de disseny – www.suinterioristes.com
Big Bang of creativity
Brainstorming, shower of ideas, storm of ideas… it seems that all the meteorological phenomena come together in the mind of creatives, also known as artists, when working on a professional project. Come rain, snow or wind, the aim is to create in order to satisfy emotions.
As designers we experiment this phase in different ways: many times external factors such as short deadlines, trends and the tastes we have to satisfy condition our work.
What should we bear in mind to be slow designers?
We have to think about the future. It depends on us to create a product that will last as long as possible and will make us proud, in order to enjoy it through the years, having the choice of reusing and recycling it. Or of living in our house that will always be our home.
We must think where we live and with whom we live: our environment and our people will help us to decide the best way to design houses, businesses and products. It is not the same to design a house in the north than in the south, up in the mountains or by the sea…
Creation: developing the project
To develop our creation we need hands, tools and materials. Our land is rich in all three. We have qualified professionals, quality tools and materials. By staying close to our people we will become slow designers because our work relations will be more human, we will get to know how our team works, they will let us be part of the process and we will all together add quality to the end product.
Designs without danger of extinction
After the Big Bang of the 90's many dinosaurs were born in the design industry: giants who accelerated the normal rhythms that we were used to, made us have more needs than necessary because that was what fashion imposed, and in the end, this saturation led to a loss of diversity and values.
Slow Design means returning to our roots, thinking of the people who will be using your designs, and of the connection of our products to our place and time. In short, as Nike says, going back to when we had the courage of having values.


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West Cancer Center and the Ovarian Cancer Awareness Foundation announced today a fundraising partnership teaming the annual Ovarian Cancer Awareness 5K Teal Run and Walk to join in the West Fight On Cycle, Run, Walk event on September 17 at Shelby Farms Park.
"We are looking forward to joining forces with West Cancer Center and the West Fight On Cycle, Run, Walk event this year to raise much-needed funds to help with the mission to saves lives by reaching out to encourage awareness, to provide support programs for patients, survivors, and caregivers; and to promote education in the fight against cancer," said Judy Childress, President of the Ovarian Cancer Awareness Foundation.
Fight On Cycle, Run, Walk will take place September 17 at Shelby Farms Park and will include a 5K run and a tribute walk in conjunction with the Ovarian Cancer Awareness Foundation; cycling events to include a 18-mile ride, a 32-mile ride, a 62-mile metric century ride, a Cyclocross event; and a Health and Wellness Expo complete with entertainment, food, and beverages.
"We appreciate the Ovarian Cancer Awareness Foundation's support and look forward to partnering for a great event at Shelby Farms to raise funds for discovery, innovation and advancement in the field of adult cancer research and patient education, care, and support," said Dr. Lee Schwartzberg, Executive Director of West Cancer Center.
For more information, please visit:
http://www.ocafoundation.org/ and http://westfighton.com/


text:
Masters of the Universe #5, "Monstroid," is by the regular creative team: Mike Carlin, Ron Wilson, and Dennis Janke. Here, Hordak summons a giant robotic crab monster to destroy He-Man.
Monstroid never got his own mini-comic, so that's why we get him here, I guess. The three-faction conflict keeps things moving at a nice pace, although things get a little random and out of hand at the end.
Carlin shows an interest in developing these characters, but he seems to have little regard for them as they've been established and developed in the past, and so he frequently takes them in strange and frustrating directions. He changes Extendar's origin from a voluntary subject to a kidnapping victim. Orko is an irresponsible five-year-old again – he's not feeding the fish? Seriously? This is like the cartoon at its most juvenile. The entire Horde is doing telepathy here, and Grizzlor seems to be inventing advanced cybernetic equipment. And Skeletor claims to be willing to die if it means taking He-Man with him.
There's not a great deal to be said about the art that hasn't been said in reviews of past issues. No major complaints.
This one's not great, but at least we seem to be on the right track.
Read it HERE


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CSKA Moskva Title Chances
Tied Anzhi 1-1, title odds down 3 to 66.8%
37 points 11-4-2
Add your own league!
How are these numbers calculated?
Big Games
How we did last week and who we should root for this week. Explain
What If
Chances based on how well the CSKA Moskva finish out the regular season. Explain
* Row combines multiple less frequent records.
Chance Will Win Championship


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text:
Tuesday, October 18, 2011
Monsters are almost done
I created these "Harold" monsters. I call them Harolds because the original was named Harold, and I can't come up with a better name (name suggestions are welcomed). :)
I hope this new store will love my dolls, as well as the customers!
Here's some photos of the plush I made, not stuffed yet.
Let's see if we can get some cute names for these buddies who were hurt, and have been sewn up. :)
Posted by Unknown at 10:19 AM
2 comments:
Will look forward to seeing these guys stuffed! They look ever so promising as they are. Have just come across you on the Plush Toys and Ragdolls team site on Etsy and invite you to follow my blog at www.ColdhamCuddliescalling.blogspot.com, while I follow you! If you enjoy it, why not visit my shop too - it's www.coldhamcuddlies.etsy.com. Hope to see you there soon!ReplyDelete
Having just commented, realised that you were kind enough to advise me as to how to fix widgets on my blog. Most grateful, but have not had the time to devote to doing it - it's on the to-do list! Thanks again for your help though!ReplyDelete
Subscribe to: Post Comments (Atom)


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This year our open day is called Fun Day
click on the social tab for more details
Nothing planned ?
Come on flower arrangers get something started.
North end of the site.
Plotholder rotovating
Relaxing in the sun
A shed with a difference
Chinese vegetables
Painting of plot 77 by Mike Conrad
THE NOTICE BOARD IS PROVIDED FOR THE BENEFIT OF ALL MEMBERS OF SPA HILL ALLOTMENT SOCIETY LIMITED AND SPA HILL ORGANIC GARDENING GROUP. Notices for posting on the board must be sent by e-mail to firstname.lastname@example.com. or handed in to the Society office on a Saturday or Sunday morning They must include the name (and if possible the Spa Hill membership number) of the member posting them. They must also include a display until date. Advertisments for private sales will be accepted but advertisments which appear to be commercial will not. There may be a delay of up to 72 hours after a notice is received before it appears on the board. Notices can only be accepted from members or affiliated organisations.
Notices posted on the board are entirely the responsibility of the person or organisation posting them. Spa Hill Allotment Society Limited and Spa Hill Organic Gardening Group can accept no responsibility for anything contained in them unless the notice is actually posted by the Society. At present this is provided as a free service to members. The Society reserves the right to reject or remove any notice without giving a reason for so doing.


text:
Well that was meant to go in the search box.
Oh well, anyone know who last night's (Sunday's) support was? They don't appear to have been Joe Gideon and the Shark.
They weren't anything special, I just want to know for future reference.
I really enjoyed the gig, though. Lots of spitting from Cave and Ellis but onto the stage not the audience.
tenebrous liar
steve 'loose lips sink ships' gullicks band.
Ah right.
This was a low point for me, I admit.
I noticed Warren Ellis spitting a lot on Saturday
He looks like how I imagine rumplestiltskin would.
warren ellis = hero
aw man they were so good.
so, so good.
i was there on saturday night....
it might well be the greatest gig I've ever been to.
Met Nick and Warren after the show, which was terrifying to say the least.
i wouldn't know what to say to nick cave.
words would fail me.
i met warren ellis at primavera and he was very pleasant. i had a photo taken with him, and i look like a complete moron. nonetheless it is one of my favourite photos :)
I think I apologies for saying hello 'like a cunt' and then mumbled something about him being a legend...
but then he hugged me! very surreal!
yeah :)
where were you stood?
and HOW pretty is that venue? oh my god.
Pretty damn pretty.
We were stood in a line from the right speaker stack, down in the pit area.
Rasputin is probably a better comparison
It was definitely one of the best gigs I've been to this year, much better than the Hammersmith show, although I did miss the first half an hour of that which didn't help matters.
I'm not sure about that, my friend
turned up late with my ticket which is why I didn't get in at the start.
Friends of mine arrived at 9.30 to get the last song before the encore.
That would imply he went on about 8.15? That sounds quite early to me. Maybe they had their watches wrong, through. :D
Who the fuck
turns up to a gig at 9:30 and expects to see the whole set? Unless it's a band with NO BACK CATALOGUE.
He's going to be on Channel 4 news in a minute...
...presenting the Turner Prize.
Gutted I missed all of theses shows
Due to lack of pissin' funds once again. Still I did catch Grinderman earlier in the year, which was unbelievable!
That show was too expensive.
As far as ATP deals go I'm guessing £150 to be able to see two shows each by Dirty Three, Grinderman and Nick Cave doesn't really get much better value. That was a good ATP.
I'm hoping to see Grinderman
next year as I believe they have a new album out then?!
I'm pretty sure I read it somewhere
I guess they liked doing something a little different and it looks like Nick Cave enjoys playing guitar.
What did people think of The Troxy ?
I thought it was awful. Hard to get a decent view, sound quality not great etc
I managed to get four rows from the front and I thought the sound was fine
much better than in places like Koko. I didn't like having to walk there in the freezing cold, but that was my fault for foolishly thinking it was a short walk from Aldgate East, instead of the half hour it took.
We discovered that the 135
would have taken us from Liverpool Street straight there in 10minutes, which we utilised on the way home.
I didn't think it was that bad
but it wasn't great. It looked nice inside and the sound seemed ok. I could see reasonably well too.
It clearly isn't designed for that amount of people though. I got my coat from the downstairs cloakroom just before the last song so I didn't have to wait, but I dread to think what the queue was like after the gig finished. The toilets were a bit of a joke too, I doubt the toilet man made much money.
Sunday's set:
Hold On To Yourself
Dig, Lazarus, Dig!
The Weeping Song
Nature Boy
Red Right Hand
Midnight Man
Love Letter
You've Got Me Eating Right Out Of Your Hand
The Mercy Seat
The Ship Song
We Call Upon The Author To Explain
Papa Won't Leave You, Henry
Get Ready For Love
Into My Arms
Nobody's Baby Now
Hard-On For Love
Stagger Lee
Mercy Seat, Deanna and We Call Upon The Author were highlights for me.
So glad I ticked it off my list...
Been wanting to see Nick Cave and the bad seeds for years and they were one of the best acts I've ever seen. Completely exceeded my expectations. Seeing clips just didn't do the live act justice - you can't take your eyes off of the guy. I thought that The Bad Seeds were awesome as well - so tight and they were heavier and more experimental than I expected. I thought that a lot of the stuff off DLD added a lot of life to the set - We Call Upon the Author and Moonland were surprise highlights, although they don't blow me away on record. Personally would have loved to hear Oh My Lord or The Carny but no complaints at all with the set.
Also, really liked the venue even though it meant I missed my train home and I got stranded. I thought that was some of the cleanest sound I've heard at any venue in London and it was really easy to get a good view.
The gentlemen's toilet queue was of Glastonbury-proportions at times. I actually stopped drinking because I couldn't face having to queue like that.
the ladies toilets were fine
very shiny!!
the cloakroom queue was epic, but while i can't speak for everyone else, i was in a post-cave daze, so in no fit state to complain about it.
the venue was SO pretty. sound was fine, and despite being stuck at the back of the standing area, could see plenty well. really really enjoyed it. pity they stopped people getting into the main pit but from a safety point of view i guess i can't really blame them.
only complaint: no tap water at the downstairs right hand side bar. this is always gay - tap water should be available at every bar.
i really liked their carpet. i was ooh-ing and aah-ing at the decor for some time.
maybe my favourite show of the year, sunday
2 hours of intensity and didn't even do todays lesson, albert goes west, lie down here or more news. great venue, stained glass fuckin lighting ornaments.


text:
Ian Bonhôte, Peter Ettedgui
Biographical, Documentary, LGBTQ
No upcoming showtimes scheduled.
Centerpiece Presentation! Saturday, July 21st, 7:00pm. High Fashion Party to follow screening in Henderson's Lounge
A personal look at the extraordinary life, career and artistry of Alexander McQueen. Through exclusive interviews with his closest friends and family, recovered archives, exquisite visuals and music, McQueen is an authentic celebration and thrilling portrait of an inspired yet tortured fashion visionary.
Sponsored by


text: The world's largest amphibious aircraft unveiled at the Zhuhai US-2- Sohu sold better than Japan India military channel information: on October 30th, Chinese independently developed large amphibious aircraft AG600 unveiled at the Zhuhai air show static display area. As the world's largest amphibious aircraft in the study, AG600 in July 23rd this year, the assembly line in Zhuhai. Reference News Network reported on November 1st: foreign media said, by Chinese designed and developed by the world's largest amphibious aircraft AG600 (Dragon -600), October 30th to the Zhuhai air show, the machine can implement the water rescue operations in complex weather conditions 2 meters high waves, water rescue once rescued 50 people. According to Singapore's Lianhe Zaobao website on October 31, reported that AG600 is one of China's largest aircraft project in the year of the project in 2009, in Zhuhai in July 23rd this year, the assembly line. The Eleventh China international aviation and Aerospace Exhibition (Zhuhai airshow) from November 1st to 6, held in Zhuhai, the exhibition of the 001 aircraft is the assembly line in July. Reported that, according to the chief architect AG600 Huang Lingcai, the captain 37 meters, with a wingspan of 38.8 meters, 12.1 meters high, with a single hull, cantilever monoplane layout and three retractable landing gear, with four sets of domestic -6 turboprop engine. The maximum takeoff weight of 53.5 tons; the maximum cruising speed of 500 kilometers per hour; the maximum flight time of 10 hours; the maximum range of over 4000 km; 20 seconds of a 12 tons of water. Reported that, as the amphibious aircraft, AG600 is capable of landing on land, and landing in the water, and with the implementation of forest fire fighting, water rescue and other special tasks, according to the needs of users with the necessary equipment to perform the conversion, marine environment monitoring, resource exploration, transportation, maritime smuggling and islands security, maritime law enforcement and the rights of other tasks. Whether tonnage or voyage, AG600 are better than Japan's recent approval of the sale of US-2 amphibious aircraft to India.相关的主题文章:


text:
Phoenix Machinery CNC Division manufactures high precision parts for key locks. We can operate on any required material such as austenitic stainless steel and reaching a tolerance up to 5 microns.
We welcome all inquiries concerning technical support, product availability and requests for quotation.
Some key lock parts we manufacture:
- Cylinders
- Key blades
- Stators inside
- Stators outside
- Webs
- Other key lock parts


text:
UP MakerSpace offers private maker parties for your office, birthday, bachelorette/bachelor, holiday, or other group event. All parties are hands on activities led by a master maker. No experience required. Bring your own refreshments and snacks. Current event offerings are listed below. All events are approximately 2 hours and can be scheduled for 5-20 people. Contact us to book your event.
Find events designed for kids here.
Multimedia Art Night$30 per person.
Not your typical paint night. Paint a colorful backdrop on wood. Hand draw or digitally design your own custom engraving while your paint dries. Before you leave we will laser engrave your design onto your masterpiece for you to bring home to the envy of all your friends.
Design and Engrave a Flask$30 per person
In need of some adult time and possibly a rad new flask? Achieve both at this event. You'll spend some time creating your very own custom design which will then be LASER engraved onto a flask, right before your eyes! You can choose to create your design the old fashioned way with pencil and paper or digitally design on computer. Cost of class includes one standard sized flask. Upgrades available. ;)
Writer's Block (Group Poetry Night)$30 per person.
Partner up and get creative with the written word. Its creative writing with a twist. Be prepared to create short writings beyond your own formation, recite your poetry to the group, and bring home your written wisdom, twisted words, and advice for the world on an engraved wood block.
Fidgetopia$30 per person.
Missed out on the Fidget Spinner Craze? Come design your own one of a kind fidget spinner. You will create your own fidget spinner design in CAD software assisted by our skilled instructors. After class we will print your design at UP MakerSpace. 2 days later, you can pick up your printed fidget spinner design and parts to assemble your spinner on your own.
Laser Cut Stencil$30 per person.
Graffiti consistently with your custom laser cut stencil. You will digitally design artwork to be laser cut into a stencil. Next put your stencil to the test with the spray booth. Walk away with your reusable stencil and spray paint art.
3D Printed Custom Cookie cutter$30 per person.
There's a new cookie on the block with your name on it. Learn vector design and CAD software while creating a custom cookie cutter which will be 3D printed at UP MakerSpace. Cutter will be available for pickup approximately 2 days after the class.
Wooden Wall Decor$30 per person.
Forever preserve your design as an engraved wooden wall hanging. You may want to hand draw the design on the spot or you may want to engrave quotes from your favorite guru. The sky's the limit, but we recommended picking a theme.
Block Printed Card Making$25 per person.
Enjoy a safe introduction to printmaking! Hand draw your own artwork and go through the steps to turn it into a reusable Styrofoam printing plate which you will use to run off a series of special cards. Choose from a variety of paper and ink colors. You will leave with basic printmaking skills, a handful of printed cards and your reusable printing plate.
Lasered Custom Stamp$40 per person.
Hand draw or digitally design a reusable rubber stamp. Choose to design with paper and marker or with graphic design software. We will laser engrave your creation into rubber stamp material and a wooden handle. You will assemble and take your new stamp with an ink pad home to leave your signature mark wherever you please.
* Most events must be scheduled 2 weeks in advance.


text:
Play Full See No Evil 2 in HD VideoNow you can play full See No Evil 2 in best quality with duration 120 Min and has been launched in 2014-10-21 and MPAA rating is 0.
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- Research
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Parasite clearance rates in Upper Myanmar indicate a distinctive artemisinin resistance phenotype: a therapeutic efficacy study
- Kyaw Myo Tun1, 2,
- Atthanee Jeeyapant3,
- Mallika Imwong4,
- Min Thein1,
- Sai Soe Moe Aung1,
- Tin Maung Hlaing1,
- Prayoon Yuentrakul3,
- Cholrawee Promnarate7,
- Mehul Dhorda5, 7,
- Charles J. Woodrow3, 5,
- Arjen M. Dondorp3, 5,
- Elizabeth A. Ashley3,
- Frank M. Smithuis2, 5, 6,
- Nicholas J. White3, 5 and
- Nicholas P. J. Day3, 5Email author
© Tun et al. 2016
- Received: 12 November 2015
- Accepted: 16 March 2016
- Published: 31 March 2016
Artemisinin resistance in Plasmodium falciparum extends across Southeast Asia where it is associated with worsening partner drug resistance and a decline in the efficacy of frontline artemisinin-based combination therapy. Dihydroartemisinin-piperaquine (DP) is an essential component of preventive and curative treatment in the region, but its therapeutic efficacy has fallen in Cambodia.
A prospective clinical and parasitological evaluation of DP was conducted at two sites in Upper Myanmar between August 2013 and December 2014, enrolling 116 patients with acute uncomplicated falciparum malaria. Patients received DP orally for 3 days together with primaquine 0.25 mg/kg on admission. Parasite clearance half-lives based on 6 hourly blood smears, and day 42 therapeutic responses were assessed as well as parasite K13 genotypes.
Median parasite clearance half-life was prolonged, and clearance half-life was greater than 5 h in 21 % of patients. Delayed parasite clearance was significantly associated with mutations in the propeller region of the parasite k13 gene. The k13 F446I mutation was found in 25.4 % of infections and was associated with a median clearance half-life of 4.7 h compared with 2.7 h for infections without k13 mutations (p < 0.001). There were no failures after 42 days of follow-up, although 18 % of patients had persistent parasitaemia on day 3.
The dominant k13 mutation observed in Upper Myanmar, F446I, appears to be associated with an intermediate rate of parasite clearance compared to other common mutations described elsewhere in the Greater Mekong Subregion. Discerning this phenotype requires relatively detailed clearance measurements, highlighting the importance of methodology in assessing artemisinin resistance.
- Plasmodium falciparum
- Artemisinin resistance
- Kelch 13 propeller
- Parasite clearance half-life
- Myanmar
Artemisinin resistance in Plasmodium falciparum is now prevalent across much of mainland Southeast Asia [1–6]. Resistance is characterized by the clinical phenotype of delayed parasite clearance [7, 8] and is associated with mutations in the propeller region of the P. falciparum kelch13 (k13) gene [6]. This marker has since been validated extensively in clinical studies and also by laboratory transfection [2–4, 9, 10]. Artemisinin resistance is clearly associated with ACT failures with reduced clinical efficacy of mefloquine-artesunate reported in Cambodia a decade ago [11, 12]. Four years after adoption of dihydroartemisinin-piperaquine (DP) in Cambodia, high failure rates were reported, with both artemisinin and piperaquine resistance as contributing factors [13–16]. Artemisinin resistance has steadily worsened along the Myanmar–Thailand border [17, 18] where the k13 C580Y mutation now predominates, and is present in central and southern Myanmar where independent mutations have emerged [2, 3, 19]. A recent molecular survey of k13 gene mutations, which obtained data from ten administrative regions, indicated that artemisinin resistance now extends across much of Myanmar [1].
The situation in relatively remote Northern Myanmar has been challenging to ascertain. Several clinical studies have been undertaken at the border between Kachin State and Yunnan Province in China [20, 21]; based on a combination of day 3 parasite positivity rates and subsequent molecular and in vitro studies [4, 5, 22] it has been concluded that artemisinin resistance is also present in this region.
Dihydroartemisinin-piperaquine is one of three artemisinin-based combinations registered in Myanmar, but it is not widely used because the main donors support distribution of artemether–lumefantrine free of charge through the government health system and international non-governmental organizations and at a reduced price in the private sector; nor was piperaquine monotherapy generally available in the past. Consistent with this there are no reports in Myanmar of reduced piperaquine sensitivity (in vivo or in vitro). DP is the only currently available drug for mass treatment in this region [23]. In order to investigate the degree and extent of artemisinin resistance in Northern and Central Myanmar, as well as the current efficacy of DP, we undertook a two-centre prospective study, using a combined protocol to characterize early parasitological responses (i.e. to assess artemisinin resistance) and the overall therapeutic efficacy of DP.
Study design
An open-label single arm clinical trial was conducted in two hospitals, one located in Myitkyina, Kachin State in Northern Myanmar and the other in Thabeikkyin, Mandalay Region in central Myanmar (Additional file 4: Figure S1). The two sites are situated in areas of low malaria transmission (entomological inoculation rate; EIR < 1) [24]. This trial was registered at ClinicalTrial.gov (NCT01350856). The Oxford Tropical Research Ethics Committee (UK) (OXTREC reference 06–11) and the Defence Services Medical Ethics Committee (Myanmar) approved the study protocol.
Study participants
Inclusion criteria were acute uncomplicated P. falciparum malaria confirmed by positive blood smear on microscopy with asexual forms of P. falciparum (including mixed infection with non-falciparum species), parasitaemia of between 5000 and 200,000 per µL determined on a thin or thick blood film, and fever defined as >37.5 °C tympanic temperature or a history of fever. Male and non-pregnant female patients aged between 6 months and 65 years were recruited; children less than 5 years of age were not included at the Thabeikkyin site because of the absence of a paediatric specialist. Patients (or parents/guardians of minors) provided written informed consent to enrol in the study; those unable to read or write provided informed consent with a witness present. In patients from 10 to 17 years of age assent was also obtained. Exclusion criteria were signs of severe and/or complicated malaria [25], haematocrit less than 25 % or haemoglobin less than 8 g/dL, acute illness other than malaria requiring treatment, administration of artemisinin derivatives within the previous 7 days, history of allergy to artemisinins or to dihydroartemisinin-piperaquine, and previous splenectomy.
Dihydroartemisinin-piperaquine (DP) was purchased as Duo-Cotecxin® from Beijing Holley-Cotec Pharmaceuticals. Primaquine (Remedica Pharmaceuticals) was provided by 3MDG. Patients received DP orally each day for 3 days, with a target daily dose of 2.4 mg/kg dihydroartemisinin and 18 mg/kg piperaquine [25]. All patients received primaquine 0.25 mg/kg single dose on day 0 after the first dose of DP. Dosing was by weight categories (See Additional file 1). If the patient vomited within 1/2 h of anti-malarial ingestion, the dose was repeated. If vomiting occurred between 1/2 and 1 h, half the dose was repeated.
Admission procedures
Patients were admitted to the hospital for at least 3 days for supervised treatment and 6 hourly blood smears. Parasite densities were estimated by blood smear every 6 h up to 48 h and daily thereafter until two negative consecutive slides were observed [26]. EDTA whole blood was collected at hour 0 and packed red cells stored at −20 °C for later k13 gene sequencing and genotyping in case of recurrence.
Follow up assessments
Tympanic temperature and haematocrit were measured every 6 h at the same time as malaria smears were taken, up to 48 h and then every 12 h until discharge from hospital. After patients were discharged from hospital, follow up assessments were performed at days 5, 7, 9, 14, 21 for malaria blood smear and haematocrit. A dried blood spot on Whatman® 3MM cellulose chromatography paper was collected on day 7 for piperaquine drug levels. Thereafter, patients were assessed weekly at the clinic and blood samples were taken for malaria smear and haematocrit until day 42. Patients unable to come to the clinic were visited by research staff at home.
The trial was monitored by the MORU Clinical Trial Support Group and data evaluated for compliance with the protocol and accuracy in relation to source documents.
Microscopy quality control measures and analysis of parasite clearance half-life
Giemsa-stained blood smears were prepared at the study sites. Parasitaemia (parasites/µl) was calculated from the thin blood film as parasitized red cells per 1000 red blood cells × haematocrit × 125.6, or the thick film as parasitized red cells × 8000/number of leucocytes counted (usually 200). All blood smears were read by a trained laboratory technician and all h0 and h72 slides, plus all slides from selected subjects were rechecked by experienced microscopists in the Malaria Laboratory, MORU, Bangkok [2].
Molecular studies
Blood samples were processed using standard techniques (See Additional file 2). After PCR amplification, the main part of the k13 gene (amino acids 210 onwards, including the whole propeller region) was sequenced. K13 sequences for a subset of patients were also incorporated into a published country-wide molecular marker survey in Myanmar in 2015 [1].
Statistical analysis
Sample size was based on WHO guidelines for single-arm efficacy studies [27]. A target sample size of 73 enables detection of a 5 % failure rate with 95 % confidence and 5 % precision for each site. An additional 10 % was included to allow for losses to follow up. Based on previous studies, this number would also enable distribution of parasite clearance half-lives to be described adequately. Data were entered into a web-based database, OpenClinica, version 3.0. Data cleaning and analysis were done by using STATA statistical software, version 13 (StataCorp) and GraphPad Prism software 6.0 (Graphpad Software Inc.). Parasite clearance half-lives were calculated by using the online Parasite Clearance Estimator tool from the Worldwide Antimalarial Resistance Network [28].
Fever clearance was defined as the time to the start of the first 24-h period during which the temperature remained below 37.5 °C. The gametocyte clearance time (GCT) was the interval from first detection to last detection of gametocytes in a peripheral blood smear. Person-gametocyte weeks (PGW) were calculated for each case as the number of weeks in which gametocytaemia was patent (excluding admission) divided by duration of follow-up, expressed per 1000 person-weeks. Estimated haemoglobin values based on haematocrit were used to define anaemia (See Additional file 3).
Continuous variables were presented as mean and standard deviation, or if the distribution was non-normal as median and interquartile range. Tests of association between two categorical variables were performed using the Chi squared test, and comparison of non-normally distributed continuous variables by Mann–Whitney U test.
Simple logistic regression was conducted for association between each potential risk factor and prolonged parasite clearance half-life, with multiple logistic regression to analyse resulting risk factors.
Baseline characteristics
Baseline characteristics of the patients by study site
Study site
Number of patients
Gender (male sex)
n (%)
86 (75.4 %)
40 (93.0 %)
46 (64.8 %)
19 (12–25)
23 (19–29)
13 (11–21)
45 (30–54)
54 (45–56)
34 (23–50)
1.57 (1.36–1.63)
1.63 (1.6–1.65)
1.47 (1.3–1.58)
18.3 (15.2–20.5)
20.5 (18.4–21.6)
16.3 (14.3–19.5)
Parasite count (geometric mean, 95 % CI)
35,011 (28,613–42,839)
36,779 (26,809–50,446)
33,982 (26,016–44,287)
Gametocytaemia on day 0
n/N (%)
10/114 (8.8)
9/43 (20.9)
1/71 (1.4)
Mixed infection
n/N (%)
13/114 (11.4)
8/43 (18.6)
5/71 (7.1)
37 (32–42)
38 (33–42)
37 (32–42)
Fever on admission
n/N (%)
37/114 (32.4)
12/43 (27.9)
25/71 (35.2)
Clinical and early parasitological responses
Clinical and parasitological responses
Study site
P value
Median time of fever clearance (IQR), hours
6 (6–12)
6 (6–6)
12 (6–18)
Median parasite clearance Half-life (IQR), hours
3.3 (2.1–4.8)
4.4 (3.4–6.7)
2.6 (2.0–3.8)
Parasite clearance time (Median, IQR), hours
42 (30–72)
72 (42–96)
36 (24–72)
Parasite clearance Half-life >4 h, n/N (%)
42/114 (37.7)
27/43 (62.8)
16/71 (22.5)
Parasite clearance half-life >5 h, n/N (%)
26/114 (22.8)
17/43 (39.5)
9/71 (12.7)
Day 3 parasitaemia, n/N (%)
20/114 (17.5)
13/43 (30.2)
7/71 (9.9)
Gametocyte carriage time (median, IQR), hours
18 (9–57)
57 (6–81)
16.5 (12–24)
ACPR on day 42, % (95 % CI)
100 (97–100)
100 (92–100)
100 (95–100)
Curative efficacy
After initial parasite clearance all patients remained parasite free (including non-falciparum malaria) until 42 days (Table 2); two patients were lost to follow-up before 42 days with negative blood films at their last follow-up visit at 7 and 28 days.
K13 sequence and parasitological response
Prevalence of Pf K13 mutations
K13 genotype
n (%)
n (%)
n (%)
Wild type
81 (71.1)
22 (51.2)
59 (83.1)
All K13 propeller mutations
33 (28.9)
21 (48.8)
12 (16.9)
Median parasite clearance half-life was 2.7 h for wild type k13 and 4.7 h for F446I mutation (p < 0.001) (Fig. 2b). The single cases of propeller mutations P443S, G538V, P574L and A676D were associated with half-lives of 6.6, 4.7, 7.5, and 2.0 h, respectively. The proportion of patients still parasite positive at day 3 was higher in infections with parasites with k13 mutations (10/33, 30.3 %) compared to those with wild type alleles (10/81, 12.3 %) (p = 0.02).
Factors associated with prolonged parasite clearance
Multivariable analysis examining relationship between clearance half-life or day 3 positivity and covariates kelch 13 propeller mutations, site and admission parasitaemia
Odds ratio
95 % confidence interval
P value
Half-life cutoff 4 h
Site (Myitkyina)
Kelch 13 (>440)
Half-life cutoff 5 h
Site (Myitkyina)
Kelch 13 (>440)
Day 3 positivity
Parasitaemia on admission (>1 % parasitaemia)
Site (Myitkyina)
Kelch 13 (>440)
Persistent parasitaemia at day 3 was significantly associated with site and parasitaemia on admission (using a cutoff of 1 %, close to the median) (Table 4); in this multivariable analysis k13 sequence was not a significant factor.
Ten patients (8.8 %) had patent gametocytaemia at the time of enrollment, with nine of these recruited in Myitkyina (Table 1). The geometric mean (95 % CI) gametocyte density on admission was 83/μL (34–201). Fourteen patients (12 %) developed patent gametocytaemia after admission. There was no association between gametocyte carriage and the presence of k13 propeller mutations at the time of enrollment (p = 0.42) or after treatment (p = 1.0), suggesting that artemisinin resistance had no effect on the proportion of patients with gametocytes at or after admission.
The median (IQR) durations of gametocyte carriage in Myitkyina and Thabeikkyin were 57 (6–81) and 16.5 (12–24) h respectively. Overall gametocyte carriage rate was 26 PGW per 1000 weeks of follow up. There was no association between gametocyte carriage duration and geographical location (p = 0.31), or parasite clearance half-life (p = 0.25). All patients with gametocytaemia cleared gametocytes within 96 h from the time gametocytes were first seen.
Haematological changes
Safety and tolerance
The median dose (IQR) received by patients for dihydroartemisinin, piperaquine and primaquine were 2.2 (2.1–2.3), 17.5 (16.6–18.5) and 0.26 (0.24–0.28) mg/kg respectively. Study medications were generally well tolerated although six patients vomited the day 0 medication, and one vomited on day 2; all were retreated according to protocol. One serious adverse event was reported at the Myitkyina site; one patient who had already missed follow-up visits died in a road traffic accident approximately 2 weeks after the last visit.
In this study conducted in Northern and Central Myanmar DHA-piperaquine was highly efficacious, despite the presence of artemisinin resistance, with an overall day 3 positivity rate of 18 % (30 % in Myitkyina) [29]. The study protocol was designed specifically to assess prolongation of parasite clearance half-lives, the hallmark of artemisinin resistance in P. falciparum [29]. Parasite clearance half-life is less prone to confounding by baseline parasitaemia than day 3 parasite positivity [28, 30, 31], and remains the gold-standard for determining resistance phenotypes needed for the characterization of artemisinin resistance [10, 32–34]. The use of clearance half-life to define artemisinin resistance was validated in western Cambodia, where a dichotomous distribution of half-lives is evident and a 5-h cut-off provides satisfactory discrimination [30]. At the Myanmar-Thailand border where longitudinal studies have been undertaken for more than two decades, the C580Y mutation only recently replaced earlier K13 mutations associated with lesser effects on parasite clearance [2, 35].
Consistent with previous data from the Myanmar-China border and molecular surveys [1, 4, 5], F446I was the predominant k13 mutation in this study. This mutation is associated with a significant slowing in parasite clearance, but these data indicate that this does not occur to the same extent as that associated with the mutations prevalent further east. The median parasite clearance half-life of F446I infections in this study was 4.7 h, less than that obtained by Huang et al. [4] in patients recruited nearby at the Myanmar–China border (less than 100 km from the Myitkyina site). This difference is most likely to reflect the more frequent measurement of parasitaemia in the current study; the protocol used 6-hourly assessment of parasitaemia in order to capture the lag phase of clearance and avoid systematic overestimation of slope half-life [26, 28]. Other factors might also have contributed to the differences, including host effects (fever, haematocrit, immune status and genetics [36]), drug factors, accuracy of microscopic assessment and stochastic effects due to sample size.
Until recently, there has been uncertainty with respect to the degree of artemisinin resistance in Northern Myanmar. The association of F446I, the prevalent k13 mutation in the region, with an intermediate artemisinin resistance phenotype is consistent with clinical and laboratory studies undertaken at the Myanmar–China border. Several publications have documented relatively low day 3 parasite positivity rates in clinical studies from Yingjiang County, Yunnan Province [4, 20], where frequencies of the F446I mutation are generally 40–60 % [4, 5, 22]. For example, in the series of therapeutic efficacy studies from Yingjiang county described by Huang et al. [4], day 3 positivity rate was approximately 12 % while k13 propeller mutation prevalence was 56 % (mostly F446I mutants). Most infections carrying k13 propeller mutants were cleared by microscopy by day 3, suggesting the presence of a 'milder' resistance phenotype than observed in the TRAC (Tracking Resistance to Artemisinin) study (centred on western Cambodia) where most patients carrying k13 mutations remained parasite positive at day 3 [2]. Two recently published studies from the China–Myanmar border have examined ring-stage survival in F446I parasites but these come to different conclusions with respect to the phenotypic effect [22, 37]. Overall, the F446I mutation prevalence has clearly risen over time at the Myanmar–China border [4, 5, 38], suggesting preferential survival after treatment compared to wild-type parasites, and thus selection.
In this study, site was also significantly associated with delayed parasite clearance (day 3 positivity and prolonged half-life), independent of k13 mutations. Most probably, this could be a stochastic effect with long half-life infections simply representing the top end of the log-normal distribution of parasite half lives observed with k13 wild-type infections [30]. This could also reflect host effects although an interesting, while an interesting although unlikely possibility is that artemisinin resistance might be mediated through an alternative (non-k13) mechanism. K13 wild-type infections remaining positive at day 3 have been found in other parts of Myanmar [39]. Genome-wide studies of parasite polymorphism will allow study of the population structure of F446I mutant parasites and determine whether underlying 'backbone' mutations play a role [32].
What is the future for DHA-piperaquine in Myanmar? At present, it remains a highly efficacious and well-tolerated treatment for falciparum malaria in Upper Myanmar, but if artemisinin resistance worsens, then increasing reliance will be placed on the piperaquine component. Worsening partner drug resistance has rapidly followed emergence of artemisinin resistance at both the Thai–Myanmar border [17] and in Cambodia, where piperaquine resistance has now emerged and DP failure rates have risen alarmingly in the last 2 years [14, 15, 40, 41].
The median (IQR) gametocyte carriage time in this study was 18 (9–57) h, significantly less than that in the TRAC study [160 (<6–252) h] where primaquine was not used [2]. Hence the addition of a single low dose of primaquine (0.25 mg/kg) resulted in low rates of gametocyte carriage and was well tolerated, with rapid haematological recovery from malarial anaemia. G6PD deficiency gene frequencies in Myanmar typically range from 10 to 20 %, so it is likely that G6PD-deficient male patients in this study were exposed to primaquine, but without significant haemolysis. This is in keeping with recent large-scale deployments in mass treatment where no serious adverse effects have been observed. Related to this, the patient population in Myitkina was predominantly young men (typically acquiring malaria because of military or mining activities in forested areas), an issue that would need to be taken into account in any systematic treatment programme.
In summary, this study shows that while treatment efficacy remains high with DHA-piperaquine, artemisinin resistance has emerged and is established in Upper Myanmar. However, the main k13 mutation observed, k13 F446I, was associated with a clearance half-life of slightly under 5 h, suggesting an "intermediate resistance" phenotype. The study also emphasizes the clearance half-life remains the gold-standard in research studies of artemisinin resistance and shows the value of frequent in vivo sampling of parasitaemia in locations where susceptibility to artemisinins is previously unknown [26]. The sampling schedule (6 hourly for 48 h then daily, until two negative slides) is more convenient for patients and investigators than that used in the TRAC study [2], but performs well [26].
Authors' contributions
KT, TH, AD, EA, FS, ND and NW designed the study. KT, MT, SA, CP, MD were responsible for fieldwork, patient care and sample collection. PY, TH and EA monitored and coordinated the study. MI undertook molecular analyses. CW, KT, AJ analysed the data. KT, AJ, CW, EA, FS, AD, ND and NW drafted the paper. All authors read and approved the final manuscript.
We thank all the participants and field staff who took part in this study. We would like to thank Mavuto Mukaka for advice in data analysis, Kyaw Soe for laboratory management, Thatsanun Ngernseng for data management and Benjamas Intharabut and Ketsanee Srinamon for microscopy quality control.
Competing interests
All authors declare that they have no competing interests.
The study was supported by a Grant from the UK Department of International Development (DFID). However the views expressed and information contained in this report are not necessarily those of or endorsed by DFID which can accept no responsibility for such views or for any reliance placed on them. KMT coordinated this study as part of his DPhil project, which is funded by the Li Ka Shing Foundation. The Mahidol Oxford Tropical Medicine Research Unit is funded by the Wellcome Trust of Great Britain. Role of the funding source. The funding agency had no role in study design, data collection, analysis or writing.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Authors' Affiliations
- Tun KM, Imwong M, Lwin KM, Win AA, Hlaing TM, Hlaing T, et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect Dis. 2015;15:415–21.View ArticlePubMedPubMed CentralGoogle Scholar
- Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014;371:411–23.View ArticlePubMedPubMed CentralGoogle Scholar
- Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, et al. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J Infect Dis. 2015;211:670–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Huang F, Takala-Harrison S, Jacob CG, Liu H, Sun X, Yang H, et al. A single mutation in K13 predominates in Southern China and is associated with delayed clearance of Plasmodium falciparum following artemisinin treatment. J Infect Dis. 2015;212:1629–35.View ArticlePubMedGoogle Scholar
- Wang Z, Shrestha S, Li X, Miao J, Yuan L, Cabrera M, et al. Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China–Myanmar border in 2007–2012. Malar J. 2015;14:168.View ArticlePubMedPubMed CentralGoogle Scholar
- Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature. 2014;505:50–5.View ArticlePubMedGoogle Scholar
- Noedl H, Se Y, Sriwichai S, Schaecher K, Teja-Isavadharm P, Smith B, et al. Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia. Clin Infect Dis. 2010;51:e82–9.View ArticlePubMedGoogle Scholar
- Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009;361:455–67.View ArticlePubMedPubMed CentralGoogle Scholar
- Straimer J, Gnadig NF, Witkowski B, Amaratunga C, Duru V, Ramadani AP, et al. Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science. 2015;347:428–31.View ArticlePubMedPubMed CentralGoogle Scholar
- Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O, Dondorp AM, et al. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc Natl Acad Sci USA. 2013;110:240–5.View ArticlePubMedPubMed CentralGoogle Scholar
- Rogers WO, Sem R, Tero T, Chim P, Lim P, Muth S, et al. Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia. Malar J. 2009;8:10.View ArticlePubMedPubMed CentralGoogle Scholar
- Denis MB, Tsuyuoka R, Poravuth Y, Narann TS, Seila S, Lim C, et al. Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia. Trop Med Int Health. 2006;11:1360–6.View ArticlePubMedGoogle Scholar
- Leang R, Barrette A, Bouth DM, Ménard D, Abdur R, Duong S, et al. Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008–2010. Antimicrob Agents Chemother. 2013;57:818–26.View ArticlePubMedPubMed CentralGoogle Scholar
- Spring MD, Lin JT, Manning JE, Vanachayangkul P, Somethy S, Bun R, et al. Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study. Lancet Infect Dis. 2015;15:683–91.View ArticlePubMedGoogle Scholar
- Saunders DL, Vanachayangkul P, Lon C. Dihydroartemisinin-piperaquine failure in Cambodia. N Engl J Med. 2014;371:484–5.View ArticlePubMedGoogle Scholar
- Chaorattanakawee S, Saunders DL, Sea D, Chanarat N, Yingyuen K, Sundrakes S, et al. Ex vivo drug susceptibility testing and molecular profiling of clinical Plasmodium falciparum isolates from Cambodia from 2008 to 2013 suggest emerging piperaquine resistance. Antimicrob Agents Chemother. 2015;59:4631–43.View ArticlePubMedPubMed CentralGoogle Scholar
- Carrara VI, Lwin KM, Phyo AP, Ashley E, Wiladphaingern J, Sriprawat K, et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai-Myanmar border, 1999–2011: an observational study. PLoS Med. 2013;10:e1001398.View ArticlePubMedPubMed CentralGoogle Scholar
- Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012;379:1960–6.View ArticlePubMedPubMed CentralGoogle Scholar
- Kyaw MP, Nyunt MH, Chit K, Aye MM, Aye KH, Aye MM, et al. Reduced susceptibility of Plasmodium falciparum to artesunate in southern Myanmar. PLoS One. 2013;8:e57689.View ArticlePubMedPubMed CentralGoogle Scholar
- Wang Y, Yang Z, Yuan L, Zhou G, Parker D, Lee MC, et al. Clinical efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria at the China–Myanmar border. Am J Trop Med Hyg. 2015;93:577–83.View ArticlePubMedGoogle Scholar
- Huang F, Tang L, Yang H, Zhou S, Sun X, Liu H. Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China–Myanmar border. Malar J. 2012;11:278.View ArticlePubMedPubMed CentralGoogle Scholar
- Wang Z, Wang Y, Cabrera M, Zhang Y, Gupta B, Wu Y, et al. Artemisinin resistance at the China-Myanmar border and association with mutations in the K13 propeller gene. Antimicrob Agents Chemother. 2015;59:6952–9.View ArticlePubMedGoogle Scholar
- WHO. Minutes of the drug resistance and containment Technical Expert Group. Geneva: World Health Organization; 2014.Google Scholar
- Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, et al. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J. 2011;10:378.View ArticlePubMedPubMed CentralGoogle Scholar
- WHO. Guidelines for the treatment of malaria. 3rd ed. Geneva: World Health Organization; 2015.Google Scholar
- Flegg JA, Guerin PJ, Nosten F, Ashley EA, Phyo AP, Dondorp AM, et al. Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives. Malar J. 2013;12:411.View ArticlePubMedPubMed CentralGoogle Scholar
- WHO. Methods for surveillance of antimalarial drug efficacy. Geneva: World Health Organization; 2009.Google Scholar
- Flegg JA, Guerin PJ, White NJ, Stepniewska K. Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator. Malar J. 2011;10:339.View ArticlePubMedPubMed CentralGoogle Scholar
- WHO. Status report on artemisinin and ACT resistance. Geneva: World Health Organization; 2015.Google Scholar
- White LJ, Flegg JA, Phyo AP, Wiladpai-ngern JH, Bethell D, Plowe C, et al. Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach. PLoS Med. 2015;12:e1001823.View ArticlePubMedPubMed CentralGoogle Scholar
- Worldwide Antimalarial Resistance Network. (WWARN). Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis. Malar J. 2015;14:359.View ArticleGoogle Scholar
- Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J, Amaratunga C, et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nat Genet. 2015;47:226–34.View ArticlePubMedPubMed CentralGoogle Scholar
- Cheeseman IH, Miller BA, Nair S, Nkhoma S, Tan A, Tan JC, et al. A major genome region underlying artemisinin resistance in malaria. Science. 2012;336:79–82.View ArticlePubMedPubMed CentralGoogle Scholar
- Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, et al. In vivo parasitological measures of artemisinin susceptibility. J Infect Dis. 2010;201:570–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Anderson TJC, Nair S, McDew-White M, Cheeseman IH, Bilgic F, McGready R, et al. Anatomy of an ongoing soft selective sweep malaria parasites driven by artemisinin treatment. In: Society for molecular biology & evolution 2014 Meeting, 8–12 June 2014, Puerto Rico. Dublin: MCI Dublin; 2014. Abstract downloadable at https://mcidublin.conference-services.net/reports/template/onetextabstract.xml?xsl=template/onetextabstract.xsl&conferenceID=3958&abstractID=814496.Google Scholar
- Amaratunga C, Sreng S, Suon S, Phelps ES, Stepniewska K, Lim P, et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect Dis. 2012;12:851–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Ye R, Hu D, Zhang Y, Huang Y, Sun X, Wang J, et al. Distinctive origin of artemisinin-resistant Plasmodium falciparum on the China–Myanmar border. Sci Rep. 2016;6:20100.View ArticlePubMedPubMed CentralGoogle Scholar
- Feng J, Zhou D, Lin Y, Xiao H, Yan H, Xia Z. Amplification of pfmdr1, pfcrt, pvmdr1, and K13 propeller polymorphisms associated with Plasmodium falciparum and Plasmodium vivax isolates from the China–Myanmar border. Antimicrob Agents Chemother. 2015;59:2554–9.View ArticlePubMedPubMed CentralGoogle Scholar
- Nyunt MH, Hlaing T, Oo HW, Tin-Oo LL, Phway HP, Wang B, et al. Molecular assessment of artemisinin resistance markers, polymorphisms in the k13 propeller, and a multidrug-resistance gene in the eastern and western border areas of Myanmar. Clin Infect Dis. 2015;60:1208–15.View ArticlePubMedGoogle Scholar
- Leang R, Taylor WR, Bouth DM, Song L, Tarning J, Char MC, et al. Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in Western Cambodia: dihydroartemisinin-piperaquine open-label multicenter clinical assessment. Antimicrob Agents Chemother. 2015;59:4719–26.View ArticlePubMedPubMed CentralGoogle Scholar
- Fairhurst RM. High antimalarial efficacy of dihydroartemisinin-piperaquine on the China–Myanmar border: the calm before the storm. Am J Trop Med Hyg. 2015;93:436–7.View ArticlePubMedPubMed CentralGoogle Scholar
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Legendary Ghanaian Rapper & Sarkcess Music Boss Sarkodie unveils the official video to "Glory" featuring Chocolate City Act Yung L who just served us with "Gbewa".
"Glory" by Sarkodie & Yung L is off Sarkodie's just premiered fifth studio Album "Highest", An LP that housed 18 tracks with a Bonus Track featuring Runtown.
"Highest" Album features numerous artists in African from Nigeria, Kenya, Ghana & Tanzania, The album is out everywhere both on Apple Music & iTunes.
Watch "Glory" Video by Sarkodie & Yung L Beneath, Don't forget to share!


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In mid-December, we posted an announcement on the blog that we submitted our Rezoning Application to the City of Durham. We also submitted the Traffic Impact Analysis (TIA) which shows the traffic impact Guess and Latta Road may see if North River Village is developed. The TIA is now available here.
Both documents are being reviewed by the City of Durham and NCDOT.
We expect the TIA review to take at least a few months. It will be springtime before the development plan is ready to be reviewed by the Planning Commission.
Continue to check back for more updates or review additional documents here. If you have any questions please review the FAQs or email us.


text: ericsvibe 37 Posted October 1, 2018 Well we are 4 games in, and we have now lost 3 starters to season ending injuries. Sitton was the first to go, and was a very hard loss. With Sitton in, we could easily run the ball. Now that Larsen is back, we had a huge drop off in running performance the last 2 games. Then Hayes goes down in the third game, hurting our run defense. I hate to say it, but Harris is a bust. He can't play the run, and is invisible on passing downs. The Dolphins promoted a DE from the practice squad to add to the rotation, and he played better than Harris against the Patriots. Now we loose Kilgore for the season, and Tannehill just became an dead QB walking. Swanson is a serviceable C, but he is a clear step down from Kilgore. The pass protection got worse as the game went on, with Gase benching Tannehill after a really bad sack. Gase admitted that he was worried about Tannehills health. Tanny seems very slow this year, like he is playing a gear short. Osweiler was much quicker getting the ball out, and was throwing with velocity compared to Tannehill. Gase also made the comment during his press conference that Tannehill had targets to throw to. I predicted that Tannehill wouldn't make it through the season, and it looks to be coming true. We have some of the best skill position players we have had in a long time, and can't capitalize on it. The Bengals are going to be blitzing us right up the middle all game. The Dolphins are going to have to sign another backup C. This is just horrible. Share this post Link to post Share on other sites


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So, I've been working on papers and stuff so much lately, that I found this to be quite refreshing.
Sorry, I'm still laughing at the fact that I had forgotten that they even included these in the he-man episodes. On those ways that we were formed before we became the formers!! Scary!


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David Kuhlmann
Professionalism, thoroughness, and tenacity all describe my experience working with Bridgette Shuler to sell my property in North Carolina. I had been trying to sell it for three years when I finally was put in touch with Bridgette. She explained her marketing approach and marketed my property with excellent photographs and descriptions. She then took the initiative to contact persons who she felt would have an immediate interest in my property. Within two weeks I had an offer, a few days after we inked a deal, and two weeks later the transaction was closed. I could not be happier and would recommend anyone buying or selling real estate in the Brevard, NC area to first contact Bridgette.
-David Kuhlmann


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The usual suspects round out the charts.
Posted By Ravi Sinha | On 23rd, Jan. 2017 Under News
Is this 2013? Well, no but that's not stopping Rockstar's Grand Theft Auto 5 from dominating physical game sales in the UK for the week ending on January 21st according to Gfk Chart-Track.
FIFA 17 is in second place followed by Call of Duty: Infinite Warfare (which was still the highest selling title in the United States for 2016 according to The NPD Group) in third. Battlefield 1 is at fourth place followed by Watch Dogs 2 at fifth. Steep is in sixth place so it's pretty good news for Ubisoft to have two of its releases in the top ten chart.
Forza Horizon 3 was in eighth place followed by Mafia 3 with a surprising return to ninth place. Overwatch managed to round out the charts at tenth place. As always, because Gfk Chart-Track doesn't take digital sales into account, the actual sales numbers are expected to be higher all around.
What will the charts look like this week with Tales of Berseria, Kingdom Hearts HD 2.8 Final Chapter Prologue, Resident Evil 7: biohazard and Yakuza 0 releasing? We'll find out next Monday so stay tuned.
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Traffic sucks, so why not start your morning off with some music? You provide the toast and we'll provide the jams.
This was the first song the Pixies released when they got back in 2004, and I really like it. It's unusual for a Pixies song in that it has the now-departed Kim Deal on lead vocals. It's got this nice manic, bonkers energy I find appealing.
Plus, I heard a lot of the lyrics came from some kid's notebook they found. I think they wrote more, because "bosses in offices on automatic drip" is too good for some kid's notebook.
Enjoy, fellow kooks!
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