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Jingle Gift Store prestashop 1.7 theme for stores selling gift items , kids toys , flowers, antic, Art, painting, stationary ,Accessories and multi purpose store. it is 100% responsive and customizable prestashop 1.7 theme.
CarBuzz is a Clean, Modern and Professional Auto Mechanic, Car Wash, Mechanic Workshops, Car Repair, Shops, Car Painting, Car focuses and auto related administrations HTML Template. This layout will be a decent starter for your business or an awesome expansion to your effectively existing organization.
Gparts - Car Parts WooCommerce Responsive Theme is a responsive and resourceful WordPress theme for automotive, car parts and auto repair website. This modern and professional design is the perfect fit for car owners, car dealerships, car rental, car repair service centers, and all automotive sectors. Gparts has the pixel perfect design and mobile-friendly layouts to attract and engage your potential audience.
Gparts - Car Parts WordPress Theme is built-in King-Composer Page Builder with faster drag & drop. So, easily customize the visual and everything to match your needs without touching a line of code. Display all the relevant information, texts, contents based on your car parts, products and services on online.
Moreover, Gparts is highly customizable with predesigned or preset page layouts. There are two unique and modern Homepage layouts available with Full-width & Boxed options. This WooCommerce theme is constructed for both functionality and flexibility. Gparts comes with tons of elements and features so that it is fully adjustable and easily editable accordance to your choice and need. Gparts has Unlimited Colors Customization, Smooth Scroll, Full-screen Background Slider, Carousel Added, 600+ Google Fonts, Custom Font Support, Font Awesome Icon, ET-line Icon, Material Design Iconic Font, Added Video, Blog, Newsletter, Contact Form 7, W3C Validate HTML Code, 40+ KingComposer Add-ons, and Child Theme.
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Note: Images are not included.
It's very suitable for Glasses, Spectacles, Goggles, lenses, Eye wear, painting, photography, portfolio, Bags, Flowers, Gifts, Electronics, Food & Vegetables, Travel, Books, Garden tools, machinery, kitchen Tools, auto parts, Instruments, speakers, Drilling tools. Look Glasses OpenCart Theme is looking good with colors combination and layout. All sub pages are customized. It is very nice with its clean and professional look.
Look Glasses OpenCart theme is a quite good choice for your online store!
It's very suitable for Tattoos, Piercing, Artist, painting, photography, portfolio, Bags, Flowers, Gifts, Electronics, Food & Vegetables, Travel, Books, Garden tools, machinery, kitchen Tools, auto parts, Instruments, speakers, Drilling tools. Tattoos OpenCart Theme is looking good with colors combination and layout. All sub pages are customized. It is very nice with its clean and professional look.
Tattoos OpenCart theme is a quite good choice for your online store!
If you were looking for a template that combines both solid appearance and fancy design elements - you found it. Your construction company website needs this Joomla template to become more efficient than ever. The design is a little aggressive, with bright orange accents, but that is just what a modern company needs. The animation effects make the site dynamic and don't affect the downloading speed, which is one of the most sufficient feature visitors pay attention to. Visitors attention is carefully focused on the detailed contacts tile and Contact Form, which encourages potential customers to contact you and make an order.
Meet gorgeous and highly functional Art Gallery template - Heeey! Perfectly crafted and loaded with great variety of plugins, it meets the needs of users who want to create a stunning online art gallery. The theme doesn't require any coding skills from you to create your own content layout. You can easily do it with the help of drag and drop Elementor page builder. Heeey also comes with JetElements addon for Elementor, which adds various custom blocks to your website's page layout, containing additional modules, not included in the standard Elementor page builder elements bundle. Embed an online schedule for your exhibitions and events with the help of Booked Appointments plugin! With this theme you will be able to show up your company's services, introduce your staff, display your satisfied clients' testimonials and much more! Being truly SEO-friendly, Heeey provides you with a codeless layouts creation and allows you to edit your website in a visual mode. Let the whole world know about your Art Gallery Responsive WordPress website!
This Industrial Company Joomla Template is designed for companies providing industrial services. Each element of the site is carefully designed and looks amazing on any screens. The speed of the site is also at the highest level due to clean and high-quality code. Made by a team of professional web designers, this template offers everything you need. It has customizable page layouts and multiple options for displaying product categories. This template also comes with a shopping cart. It also provides various colors and styles, built-in modules, and much more. Download and install this Industrial Company Joomla Template and you'll get a 24/7 lifetime support, free of charge.
CarSpa - Carwash HTML Template is a clean and modern designed HTML template for Car Wash and Car Repair websites. This responsive HTML5 template is built with most popular CSS framework Bootstrap. It is a perfect solution for the website of car wash, car cleaning, auto wash, car repair, auto mechanic, car repair shops, garages, automobile mechanicals, mechanic workshop, auto repair, car workshop, auto workshop, car service, tyres, auto care, car care, car maintenance, and vehicle diagnostics.
CarSpa has a smooth design with lots of useful features. You will get one unique Homepage with 13 HTML pages like service page and news page. The full width slider will vividly showcase your content, image, logo and service related information. You can display your services, process, achievement, pricing plan, team members, projects, and latest news.
With CarSpa, get Google Fonts, Well Commented HTML & CSS Files, and A Detailed Documentation. Try this cross-browser optimized template CarSpa - Carwash HTML Template now.
Note: Images are not included.
Tinker - Car Repair HTML Template is a best car repair and maintenance template for your automotive and mechanic website. This modern and responsive template is suitable for car repair shops, brake shops, car dealers, car rental agencies, and many other small businesses like car washes.
The user-friendly Tinker HTML Template is constructed for both functionality and flexibility. It is built based on Bootstrap framework, using valid HTML5 & CSS3.
There are 5 Home Pages and total 86 HTML pages available. The powerful features of Tinker are Mega Menu, Nivo Slider, Blog Different Styles, Different Shop Styles, Shopping cart, Checkout, Wishlist, Dynamic Contact Form, Google Fonts and Material Icon Font, and 20+ Shortcodes. Overall, get 30+ exclusive features in Tinker - Car Repair HTML Template.
Don't waste your more valuable time on other options and try the best repair service template Tinker - Car Repair HTML Template for your website.
Note: Images are not included.
Welcome to Car Mech Theme from Designthemes.
Car Mech Theme is a delightful theme from Designthemes that offers 3 variants of Homepages and 2 variants of About Us page. In addition, Car Mech theme offers many pages such as Why Us page, Services page with 4 types of Blogs in Design, Layout Details and Blog default besides and different styles of Portfolio, a Team Page and a Side navigation page besides a Product page.
Car Mech theme is designed by the Power Elite Author Designthemes, who have developed more than 100 themes in WordPress besides other platforms like Shopify. Offering their expertise in every page, you have a winner in your hands as Car Mech Theme.
Each page speaks volumes about the special services you will be providing. Using the Sliders, spectacular content could be created to impress your visitors. Let us go deeper to check out the features offered in Car Mech Theme.
WP Page Builder: Earlier known as the Visual Composer, this Plugin makes designing of a site into a simple Drag & Drop affair that everyone would simply love to get their hands on. Using the WYSIWYG-what you see is what you get-interface, it is a piece of cake to design your website like a professional!
Visual Composer Ultimate Addon: Includes Visual Composer premium addon elements like Icon boxes, model Popups, Info Box, Interactive Banner, Flip Box, Info List & Counter. Best of all - provides A Font Icon Manager allowing users to upload / delete custom icon fonts. Parallax, Video Backgrounds, Row effects, CSS3 animations, icon fonts and much more!
No coding needed: The Drag & Drop Page Builder makes everyone a designer without the coding knowhow! The power of visual composer is integrated in Car Mech Theme. Create pages quickly with few clicks in few minutes with the help of Visual Composer and custom Car Mech Theme shortcodes.
Unyson: Unyson is a free Plugin that is easy to configure. It offers the Drag & Drop framework coming as it does with a bundle of extensions which will work from the backend real fast and easy. Using Unyson, you can create backup and import demo content besides archiving the demo content for migration.
Unyson One Click Importer: If you like the demo content in Car Mech theme, no problems. You can easily import the demo content using the Unyson One Click Importer. Not only that, it saves you time as you need not create content from the scratch for your site. Your site would look exactly like the theme demo page. You only need to customize and modify it to suit your requirements such as adding your logo and your content. It is simple to import the demo content using the Unyson One Click Importer. Identify the demo you want to import, click install to import the dummy content like in demo.
Kirki: Kirki is the ultimate toolkit for theme developers using the WordPress Customizer. Car Mech theme lets you take advantage of its advanced features and flexibility. Simply by abstracting the code, it is easy for everyone to design beautiful and meaningful UI.
In addition, you can easily add configurations for your projects. The ease with which you could do is the most useful part of Kirki. It helps you save time which is great! Create you panels and sections. Customize and add fields with ease.
Designthemes Core Features Plugin: A simple WordPress Plugin designed to implement core features of DesignThemes. Version 1.0 of this Plugin is integrated into the themes by DesignThemes. This Plugin is a repertoire of all the shortcodes and custom post types by Designthemes. It is compatible with Visual Composer extensions and other third party APIs. Therefore, designing of the layout and pages become a lot simpler with this Plugin.
Layer Slider: LayerSlider is a premium multi-purpose animation platform. Using this Plugin you can create amazing Sliders, image galleries, slideshows with mind-blowing effects, landing pages or even a full websites. Create gorgeously animated content in your site using Layer Slider.
Slider Revolution: It is not just a slider but a new way to deliver ideas. More than 4 million websites are powered by slider revolution. Slider Revolution is an innovative, responsive WordPress Slider Plugin that displays your content the beautiful way. Whether it's a Slider, Carousel, Hero Scene or even a whole Front Page, the visual, drag & drop editor will let you tell your own stories in no time!
360 Product Rotation: You would be able to create a 3600 product view from a given set of photos. This Plugin works in 3 steps. You can use the Sample Archive. Else, upload your own images. Finally, Upload the archive in the WP Admin» Media»360 Views. All you have to do now is to copy and paste the short code into any page or post and you are done! Using the free 3DRT Setup Utility for more features like 3600 Product view.
Contact Form 7: Car Mech Theme offers Contact Form 7 using which you can design as many forms with an unlimited number of input row fields in your form. You can design your own forms and limit spam and increase conversion. When you are running a site, there may be different requirements for forms to be configured from time to time. Contact Form 7 handles all.
WooCommerce: WooCommerce is a free eCommerce plugin that allows you to sell anything, beautifully. Built to integrate seamlessly with WordPress, WooCommerce is the world's favorite eCommerce solution that gives both store owners and developers complete control. The WooCommerce Plugin would enable you to sell online and receive payments in multiple currencies as soon as your site is configured!
WordPress Importer: The WordPress Importer will import the following content from a WordPress export file: Posts, pages and other custom post types. In addition, Comments, Custom fields and post meta, Categories, tags, custom taxonomies as well as Authors and more from a WordPress export file
YITH WC Wishlist: This Wishlist is one of the most useful features of an e-commerce site. On one side, it encourages users to come back, allowing products tracking they consider interesting until the purchase step. On the other, if users share their Wishlist — to friends, or through social networks — this will enhance the sales and will help the promotion of your online business.
Breeze: Breeze is a WordPress cache plugin with extensive options to speed up your website. Breeze is a free, powerful, user-friendly WordPress Caching Plugin developed by the Cloudways team. It offers various options to optimize WordPress performance at various levels. Breeze excels in the following areas: Performance: Breeze improves website speed and resource optimization. Other features include file level cache system, database cleanup, modification. Convenience: Breeze is easy to install and configure directly from WordPress. Simplicity: Breeze is designed to be simple for all users. Just install and activate the plugin and you'll see the results instantaneously.
Heartbeat Control: This Plugin completely controls the WordPress heartbeat. It allows you to easily manage the frequency of the WordPress heartbeat API with just a few clicks. The heartbeat API can be disabled entirely and allowed for only specific locations. Heartbeat intervals can be modified between 15 and 300 seconds between requests, saving on server resources.
Shortcodes galore: Car Mech Theme offers a plethora of shortcodes to configure your modules like tabs, accordions, buttons and tooltips. The shortcodes offered in Car Mech Theme is mind boggling. Well, almost every conceivable need has been analyzed and these shortcodes have been included. All the requirements of your site for Blockquotes, Buttons & Lists, Carousel, Columns, Contact Info, Content Shortcodes, Custom Posts, Fancy Boxes, Icon Boxes, Image With Caption, Miscellaneous, Number Counter, Pricing Table, Progress Bar, Tabs & Toggles, Team, Testimonials, Carousel Testimonials, Timeline and Typography.
Regenerate Thumbnails: Regenerate Thumbnails lets you regenerate the thumbnails for your image attachments. This is particularly useful if you've changed any of your thumbnail dimensions. Or had changed to a new theme with different featured post image dimensions. You can either regenerate the thumbnails for all image uploads, individual image uploads, or specific multiple image uploads.
Akismet Antispam: Akismet anti spam is used by millions as Akismet offers the best protection from spammers. Protect your blog from spam using Akismet which keeps your site protected even while you sleep! It is simple to get started with Akismet. Just activate the Akismet plugin and set up your API key in Akismet Settings. Simple, right?
Typography: With more than 600+ Google webfonts and the FontAwesome icons, you can set any color or size in your site and design your pages at will. You will become a professional designer by adding Google Fonts with typography field. In addition, you could add tooltips to help your users.
Legendary Support: Using the extensive documentation, knowledge base and video tutorials you can get any clarification you may require about Car Mech Theme, 24/7.
NOTE: Images used in the demo are not included for download, these images are copyrighted, if you are planning to use the photos we can provide the links to buy license.
It's time to make your architecture company more successful! Bright Profitex WordPress template will give your business a fresh coat of paint. First of all - it is really easy to install and maintain. You only have to click once and installation process will begin. All the elements are customizable and thanks to Elementor Page Builder compatibility re-shaping of website's look becomes a child's play. The theme also contains JetElemets addon for Elementor, which adds various custom blocks to your website's page layout, containing additional modules, not included in the standard Elementor page builder elements bundle. The template has lots of cool animation effects, thus it downloads rapidly and doesn't make a user wait. Several gallery layouts will give you an opportunity to show clients your best works in the best way. There's also a blog functionality - to share news and insights.
SH BUILDER is a multi purpose landing page template built for construction, building companies and business. It's fully responsive and built with bootstrap v3.3.7 and looks attractive at all screen sizes whether it is a desktop, laptop, tablet, or mobile. You will be easily able to customize it for your needs. The clean and well commented code allows easy customization of the theme. The layout is drag responsive and looks attractive at all screen sizes whether it is a desktop, laptop, tablet, or mobile. The theme includes 4 different variations for the top most important part of the page. You can choose the best according to your needs. We believe SH BUILDER will help you to start your startup quick and easy.
Pieces of art need an exceptionally beautiful surrounding. A painting online store has to highlight pictures and doesn't distract visitors from observing art. Artrite Shopify template is created accurately to sell art and has all the necessary functionality. A convenient shop has a quick view, wishlist and shopping cart, which makes purchasing easier and more pleasant. Multicurrency module allows customers from other countries understand how much they will pay for the product. Template's design is bright, but not annoying and fully responsive to fit all types of screens. The template is provided with 24/7 tech support that will be able to resolve all possible issues of installing or maintaining it.
Create a fast and reliable website for your construction company, which works on all types of devices, by using this Construction Company Joomla Template. It was created using a clean and elegant design with close attention to details. It has a nice appearance and offers huge options for customizing the template parameters. In addition, it comes with advanced features, allowing you to make changes without editing the code. The template is suitable for creating fully functional construction company website. This template is fast, easy to use and simple to tweak. Choose from many different styles to customize your template to make it look really unique. Owing to the Virtuemart integration, you can build a fully-featured web store on the basis of the Construction Company Joomla Template.
Car Wash is a responsive Unbounce Template best suitable for car wash or auto detail services, car repair shop or auto painting shop. The Template is also suitable for any small business like car rental, auto glass or for any handyman, serviceman or skilled worker like car dealer, motorcycle mechanic or automotive technician.
Unbounce Landing Page Builder
Responsive Design
Unique and Creative Design
Cross Browser Compatible
Free Icon Fonts
Documentation Include
Clean Design
Easy To Customize
Parallax Scrolling
Easy to Edit
No Code Required
Modern Design
Powerful & Lightweight
Unique and Creative Design
Quick Support
Desktop + Mobile Versions
Builder is a business theme designed specifically for construction, building companies and those offer building services. We present you with responsive, highly customizable design that will always satisfy your customers. Builder has everything you need to tell potential customers who you are and show them what you can do
Please note that images used in live preview are not included in the package. This HTML Pack dose not contain PSD files. If you have any questions please feel free to email via my user page contact form here. Thank you!
BuildLab - is a clean building construction & renovation Joomla Template. Anyone can use it for building, construction, renovation, architecture, business, company, corporate, electricity, engineering, industry, interior, isolation, maintenance, painting, projecting etc. This template comes with a drag and drop framework also number 1 page builder to ensure you can easily design your website just how you like it.
The layout looks beautiful at any size, be it a laptop screen, iPad, iPhone, Android Mobile or tablets.
It comes with high-quality multipurpose demos and one page template and many built-in inner pages such as service pages, portfolio pages, team pages, testimonials pages, blog layouts etc. so that you spend as little time working on your new website as it's possible. We designed it according to all the latest trends, techniques. It will make your site a real stand out.
Note: All images are just used for Preview Purpose Only. They are not part of the template and NOT included in the final purchase files.
Art Deco template is a creative solution both for an online art store or a personal artist's portfolio. Thanks to responsive design all the magnificent photos of your art products will look perfect on every device - no matter is it a PC or a smartphone, Android or iOS. The template is easy to install and built-in Elementor Page Builder makes it also easy to use and maintain. You will need no special skills to sculpt your website according to your taste. The template is also WooCommerce and Ecwid compatible, so there won't be any problems with building an online shop either. With Art Deco template you will be able to show your creativity to the whole world.


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現在位置 : RA > 免疫調節藥 - 磺胺藥 (撒樂 / 斯樂腸溶錠) (sulfasalazine, salazopyrine)
認識 免疫調節藥 -- 磺胺藥 (撒樂) (sulfasalazine, salazopyrine)
免疫調節藥 = 疾病調整型抗風濕病類藥物
(DMARD, disease modified anti-rheumatic drug)
● 一群具有調整免疫系統及抗發炎作用的藥物
● 減緩及控制風濕疾病的惡化
● 互相組合使用效果加強
● 須使用至少 3-6 週後方可產生效果 (有時效果很快顯見)
磺胺藥 (撒樂 / 斯樂腸溶錠) (sulfasalazine, salazopyrine)
● 不易溶解腸胃吸收差
little absorption of intact Sulfasalazine: insoluble
● 經腸內菌分解
cleaved by colonic bacteria to
(1) Sulfapyridine: 抗風濕作用 (antirheumatic effect)
(2) 5-aminosalicytic acid: 抗發炎作用 (anti-inflammatory effect)
● 發生效果 Onset: 需 4 週時間
● 類風濕性關節炎 RA: 效果等同金劑 gold or d-penicillamine, 可阻止關節破壞 able to retard erosion of RA
● 每日一顆 500mg QD 先使用一週, 之後每週增加一顆
● 直到增加到治療劑量
● 最大劑量: 一次2顆, 一天3次
● 不可咬碎或磨粉
● 可飯後服用
● 須補充水份防止結晶尿
● 白血球降低 Leukopenia: 1-3% 的病患, 和劑量有關, 多發生在頭 6 個月
● 皮膚:
(1) 皮膚過敏癢疹: 1-5% 的病患
(2) Steven-Johnson's syndrome
(3) 有過敏病史者須小心使用
● 肺部: 可逆性急性嗜酸性白血球性纖維性肺炎
● 腸胃不適: 恶心, 腹痛
(1) 腸溶錠劑型可改善
(2) 服用一段時間後會改善
● 中樞神經: 頭痛, 頭暈
● 肝臟毒性
(2) 通常 3 個月內回復正常
(3) 肝腎功能不良須減量
Sulfasalazine is an old drug still occasionally used to treat RA. It combines an aspirin-like pain reliever with an antibiotic sulfa drug. Side effects are usually mild. Nausea and abdominal discomfort are the most common complaints. The drug increases sun sensitivity. Take precautions to avoid sunburn.
Sulfasalazine for Rheumatoid Arthritis
Sulfasalazine (SSZ)
Sulfasalazine (brand name Azulfidine in the U.S., Salazopyrin and Sulazine in Europe and Hong Kong) was developed in the 1950s specifically to treat rheumatoid arthritis. It was believed at the time that bacterial infections were the cause of rheumatoid arthritis. Sulfasalazine is a sulfa drug, (a derivative of mesalazine) and is formed by combining sulfapyridine and salicylate with an azo bond. It may be abbreviated SSZ.
Sulfasalazine is used in the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is also indicated for use in rheumatoid arthritis and used in other types of inflammatory arthritis (e.g. psoriatic arthritis) where it has a beneficial effect. It is often well tolerated compared to other DMARDS.
In clinical trials for the treatment of chronic alcoholics,
sulfasalazine has been found to reverse the scarring associated with cirrhosis of the liver. Cells called myofibroblasts, which contribute to scar tissue in a diseased liver, also appear to secrete proteins that prevent the breakdown of the scar tissue. Sulfasalazine appears to retard this secretion.
A study at University of Newcastle found that the drug may also act to aid the healing of cirrhosis of the liver.
It is usually not given to children under 2 years of age.
The use of sulfasalazine in inflammatory bowel disease has declined due mainly to the fact that it yields the metabolite sulfapyridine which gives rise to side-effects such as agranulocytosis and hypospermia. However, the other metabolite of sulfasalazine, 5-aminosalicylic acid (5-ASA) is attributed to the drug's therapeutic effect. Therefore, 5-ASA and other derivatives of 5-ASA, are now usually preferred and given alone (as mesalazine), despite their increased cost, due to their more favourable side-effect profile.
Sulfasalazine has also been used successfully to treat cases of idiopathic urticaria that do not respond to antihistamines.
Mode of action
Sulfasalazine, and its metabolite 5-ASA, are poorly absorbed from the gut. Its main mode of action is therefore believed to be inside the intestine.
Bowel disease
In Crohn's disease and ulcerative colitis, it is thought to be an antinflammatory drug that is essentially providing topical relief inside the intestine. It does this via a number of mechanisms such as reducing the synthesis of inflammatory mediators known as eicosanoids and inflammatory cytokines. However, unlike glucocorticoids (another class of drug used in the treatment in inflammatory bowel disease), sulfasalazine is a mild immunosuppressant.
When treatment for arthritis is successful, pain, joint swelling and stiffness will be reduced and this may slow down or stop the development of joint damage. The precise reasons why sulfasalazine are effective in various forms of arthritis is not clearly understood.
Because sulfasalazine and its metabolite 5-ASA are poorly absorbed into the bloodstream, it is surprising that the drug is effective against symptoms outside of the intestine. One possible explanation is that, given that ulcerative colitis produces arthritic symptoms, the arthritic symptoms are actually a product of unrecognized ulcerative colitis, which is effectively treated with sulfazalazine.
The other metabolite, sulfapyridine, is absorbed into the blood, and is believed to be the source of the side-effects discussed below. It is possible that the sulfapyridine is responsible for some of the anti-arthritic effects of sulfasalazine.
Side effects
Sulfsalazine metabolizes to sulfapyridine. Serum levels should be monitored every three months, and more frequently at the outset. Serum levels above 50 μg/l are associated with side effects. In rare cases, Sulfasalazine can cause severe depression in young males. It can also cause temporary infertility. Immune thrombocytopenia has been reported.
Sulfasalazine inhibits dihydrofolate reductase, and can cause folate deficiency and megaloblastic anemia.
Sulfasalazine can cause hemolytic anemia in people with G6PD deficiency.
Sulfasalazine Tablets, USP
Sulfasalazine Description
Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration.
Therapeutic Classification: Anti-inflammatory agent.
Chemical Designation:
5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid.
Chemical Structure:
Molecular Formula: C18H14N4O5S
Sulfasalazine - Clinical Pharmacology
The mode of action of Sulfasalazine (SSZ) or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of SSZ, SP, and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety.
In vivo studies have indicated that the absolute bioavailability of orally administered SSZ is less than 15% for parent drug. In the intestine, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. Of the two species, SP is relatively well absorbed from the intestine and highly metabolized, while 5-ASA is much less well absorbed.
Following oral administration of 1 g of SSZ to 9 healthy males, less than 15% of a dose of SSZ is absorbed as parent drug. Detectable serum concentrations of SSZ have been found in healthy subjects within 90 minutes after the ingestion. Maximum concentrations of SSZ occur between 3 and 12 hours post-ingestion, with the mean peak concentration (6 μg/mL) occurring at 6 hours.
In comparison, peak plasma levels of both SP and 5-ASA occur approximately 10 hours after dosing. This longer time to peak is indicative of gastrointestinal transit to the lower intestine where bacteria mediated metabolism occurs. SP apparently is well absorbed from the colon with an estimated bioavailability of 60%. In this same study, 5-ASA is much less well absorbed from the gastrointestinal tract with an estimated bioavailability of from 10 to 30%.
Following intravenous injection, the calculated volume of distribution (Vdss) for SSZ was 7.5 ± 1.6 L. SSZ is highly bound to albumin (>99.3%) while SP is only about 70% bound to albumin. Acetylsulfapyridine (AcSP), the principal metabolite of SP, is approximately 90% bound to plasma
As mentioned above, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. Approximately 15% of a dose of SSZ is absorbed as parent and is metabolized to some extent in the liver to the same two species. The observed plasma half-life for intravenous Sulfasalazine is 7.6 ± 3.4 hours. The primary route of metabolism of SP is via acetylation to form AcSP. The rate of metabolism of SP to AcSP is dependent upon acetylator phenotype. In fast acetylators, the mean plasma half-life of SP is 10.4 hours while in slow acetylators, it is 14.8 hours. SP can also be metabolized to 5-hydroxy-sulfapyridine (SPOH) and N-acetyl-5-hydroxy-sulfapyridine. 5-ASA is primarily metabolized in both the liver and intestine to N-acetyl-5-aminosalicylic acid via a non-acetylation phenotype dependent route. Due to low plasma levels produced by 5-ASA after oral administration, reliable estimates of plasma half-life are not possible.
Absorbed SP and 5-ASA and their metabolites are primarily eliminated in the urine either as free metabolites or as glucuronide conjugates. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. The calculated clearance of SSZ following intravenous administration was 1 L/hr. Renal clearance was estimated to account for 37% of total clearance.
Special Populations
Elderly patients with rheumatoid arthritis showed a prolonged plasma half-life for SSZ, SP, and their metabolites. The clinical impact of this is unknown.
Small studies have been reported in the literature in children down to the age of 4 years with ulcerative colitis and inflammatory bowel disease. In these populations, relative to adults, the pharmacokinetics of SSZ and SP correlated poorly with either age or dose.
Acetylator Status
The metabolism of SP to AcSP is mediated by polymorphic enzymes such that two distinct populations of slow and fast metabolizers exist. Approximately 60% of the Caucasian population can be classified as belonging to the slow acetylator phenotype. These subjects will display a prolonged plasma half-life for SP (14.8 hours vs. 10.4 hours) and an accumulation of higher plasma levels of SP than fast acetylators. The clinical implication of this is unclear; however, in a small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed a higher incidence of adverse events.
Gender appears not to have an effect on either the rate or the pattern of metabolites of SSZ, SP, or 5-ASA.

subset: commoncrawl


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Member News
Have you been promoted, opened a retail section of your store, opened a new branch up, or anything else exciting? Let us know so we can help spread the word!
Haller Enterprises Announces New Promotions/New Roles
Lancaster, PA, June 1, 2015 – To accommodate tremendous 2014-15 companywide growth, Haller Enterprises is proud to announce the following promotions and new roles for key employees across multiple business units and Haller Central PA branch locations. These changes will become effective during the months of May-June, 2015.
Aaron Becker, Change-out Sales Manager, has been promoted to Vice President of Residential Sales, where he will be responsible for the continued growth of our change-out sales unit. He will also be joining the Haller Executive Team.
Edward McFarlane, Vice President of Sales and Training, has assumed a new role as Vice President of Marketing and Development. Edward will oversee all Haller marketing, new product development, training, and employee development initiatives.
Ken Walton, Vice President Design and Estimating, has assumed a new role as Vice President of Commercial Design and Sales. Ken now oversees Commercial Services Group sales, while continuing to manage all aspects of design, estimating, and engineering.
Drew Fitzkee, Mechanicsburg Branch Manager, has assumed the role of Residential Electrical Field Manager based out of Lititz. Drew will be responsible for all residential electric service technicians, retro electricians, electrical generators and service upgrades in change-out, Residential New Construction electricians, and will provide support in commercial electric
Scott Weaver, Residential New Construction Electrical Field Manager, has transitioned to the role of Purchasing Manager. This is a major step toward Haller's unified purchasing development process.
Ryan Hartsough, York Branch Manager, has transitioned to the role of Mechanicsburg Branch Manager. Ryan will assuming the responsibility over all Residential New Construction, Change-out, and Residential HVAC Service employees based out of Mechanicsburg. Ryan adds over 12 years of new construction experience to his new role as Branch Manager at Mechanicsburg.
Brian Suchy, Commercial Services contract salesman, has been promoted to the role of York Branch Manager. Brian oversees change out installations in York and Mechanicsburg; and Residential HVAC Service technicians based out of York. Brian will continue to support Commercial Services Group sales.
Kenny Rogers, General Manager of Branch Operations, has been promoted to HVAC Operations Manager. In his new role, Kenny is responsible for all HVAC departments including Residential New Construction, Commercial New Construction, Retro, and Commercial Services Group HVAC.
Dwayne Stauffer, Safety and Production Manager, has moved to the role of Safety and Risk Control Manager. Dwayne is now responsible for all Haller safety and risk control activities, as well as all Lititz warehouse and Residential New Construction project coordination. Dwayne will be responsible for Service Warehouse operations, and has assumed the responsibility over all fleet operations.
Leslie Cloonan will continue as Service Manager at Lititz. Leslie will continue to oversee all service office functions, and will now also oversee the Service Dispatch department.
EXTON, PA – First Resource Bank (OTCQX: FRSB) is pleased to announce it has been named to the 2015 OTCQX ® Best 50, a ranking of 50 top-performing companies traded on the OTCQX Best Marketplace last year.
The OTCQX Best 50 is the first-ever annual ranking of strongly performing U.S. and international companies traded on the OTCQX marketplace. The ranking is calculated based on an equal weighting of one-year share price performance and average daily dollar volume growth in the previous calendar year. All companies in the 2015 OTCQX Best 50 were traded on OTCQX on December 31, 2014.
"We are thrilled to have First Resource Bank named to the 2015 OTCQX® Best 50", said Glenn B. Marshall, Chief Executive Officer. "This honor recognizes a year where we achieved record earnings and moved to an enhanced trading platform, OTCQX, which continues to provide a material benefit to our shareholders."
For the complete 2015 OTCQX Best 50 ranking, visit http://www.otcmarkets.com/content/doc/2015-OTCQX-Best-50.pdf.
The OTCQX Best Marketplace offers the best informed and most efficient trading for established, investor-focused U.S. and international companies. To qualify for OTCQX, companies must meet high financial standards, demonstrate compliance with U.S. securities laws, be current in their disclosure and be sponsored by a professional third-party advisor. OTCQX companies are distinguished by the excellence of their operations and diligence with which they convey their qualifications.
Philadelphia Area Closets by Design Takes Home Top Honors in Home Design
Custom Closet Franchise Places in a Nationwide Design Competition Highlighting Past Projects
EXTON, PA. – Locally owned Closets by Design returns to Exton after winning numerous awards at the 2015 Cabinets and Closets Expo "Top Shelf Design Awards," recently held in Chicago. The honors are awarded annually to recognize designers from across the country for their creative closet and home organizational designs.
During the 2015 award ceremony, Closets by Design of Exton was announced as the winner in the categories of Garage: Under 600 square feet and Closet: Greater than 18 linear feet and took home an honorable mention in the Closet: Under 18 linear feet category.
"It means a lot to see the work of our designers, and the entire Exton Team, to be recognized on the national level. This is the third year in a row our location has taken home top honors at the competition and we will continue to strive to produce work worthy of honors," said Charles Waterman, owner of Closets by Design in Pennsylvania and Delaware. "Awards like these show that we are able to stay innovative and ahead of the pack, which is very important to our customers."
Designers at Closets by Design submitted dozens of projects and a select few were chosen to be professionally photographed and submitted for consideration at the awards. Waterman says that to win an award these days, the designs have to be the perfect balance of "form and function" which is exactly what the winning designs were.
"It truly is an honor to win one of the design awards," said Kelly Clark, Designer at Closets by Design of Exton and winner of the Closet: Greater than 18 linear feet award. "I was really proud of the job when it was completed, but winning this award gives me extra motivation to move the bar even higher for future projects."
For more information or to schedule a free in-home consultation with Closets by Design of Exton please call 610-644-4143 or visit www.closetsbydesign.com.
About Closets by Design
Since 1982, Closets by Design has built a reputation as a leader in the closet organizing and storage remodeling industry. From no obligation in-home consultation to custom tailored designs to the highest quality product construction, Closets by Design emphasizes a commitment to complete customer service and total customer satisfaction. The concept began offering franchise opportunities in 1997 and currently has 43 territories across the United States and Canada. Closet by Design offers franchise opportunities in large exclusive territories. Closets by Design has been ranked in Entrepreneur magazine's top 500 franchises as a leader in the home organization category. For more information, please call 1-800-377-5737 or visit www.closetsdesign.com. Interested franchisee candidates can visit www.closetsbydesign.com/franchise-opportunities.
EXTON, PA – First Resource Bank (OTCQX: FRSB) announced that the Board of Directors has declared a special cash dividend of four cents ($0.04) per share to shareholders of record as of May 8, 2015. The payment date for the dividend will be May 22, 2015.
President & CEO, Glenn B. Marshall stated, "The Board of Directors consistently manages the Bank's capital needs to provide support for our steady balance sheet growth while also providing a return on investment for our shareholders. This the second special cash dividend in the Bank's history which coincides with the opening of our second branch earlier this month in West Chester. We feel that combining growth with a current return to our shareholders is a responsible balance to meet all of our stakeholder's needs."
Preferred Transcriptions Receives 2014 Best of Eagleville Award
Eagleville Award Program Honors the Achievement
EAGLEVILLE November 25, 2014
Preferred Transcriptions has been selected for the 2014 Best of Eagleville Award in the Universities & Colleges category by the Eagleville Award Program.
Each year, the Eagleville Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Eagleville area a great place to live, work and play.
Various sources of information were gathered and analyzed to choose the winners in each category. The 2014 Eagleville Award Program focuses on quality, not quantity. Winners are determined based on the information gathered both internally by the Eagleville Award Program and data provided by third parties.
About Eagleville Award Program
The Eagleville Award Program is an annual awards program honoring the achievements and accomplishments of local businesses throughout the Eagleville area. Recognition is given to those companies that have shown the ability to use their best practices and implemented programs to generate competitive advantages and long-term value.
The Eagleville Award Program was established to recognize the best of local businesses in our community. Our organization works exclusively with local business owners, trade groups, professional associations and other business advertising and marketing groups. Our mission is to recognize the small business community's contributions to the U.S. economy.
Maillie LLP Appoints Breslawski to Partner
Mont Clare, PA – November 13, 2014
Maillie LLP is proud to announce that Bill Brewslawski has been admitted to the Partnership effective October 1, 2014. Maillie LLP is a regional public accounting firm with offices in Mont Clare, PA, West Chester, PA, and Wilmington, DE.
Breslawski joined Maillie in 1995, and has extensive experience with clients in the areas of real estate, manufacturing, not-for-profits and government organizations, and he has a special expertise in tax and auditing. In addition, Bill oversees Human Resources for the firm.
According to Managing Partner, Bob Caruso, "Bill has been a tremendous asset for the firm, and we are pleased to welcome him into the Partnership."
Bill sits on the Finance Committee for both the Sacred Heart Parish in Royersford, PA and Holy Cross Regional Catholic School in Collegeville, PA. He is active with the Rotary Club of the Spring-Ford area (Treasurer and Past-President), and the TriCounty Area Chamber of Commerce (Board Member) in Pottstown, PA. Bill is a resident of Limerick, PA where he resides with his wife and three children.
About Maillie LLP Maillie LLP is a regional public accounting firm that provides accounting, attestation, tax and financial consulting across diverse industries. Maillie LLP has been recognized as a Top-25 Regional Firm by the Philadelphia Business Journal and as a Top-200 National Firm by Inside Public Accounting. Maillie has 100 employees and was founded in 1946. For more information, please see www.maillie.com.
A New Era at Title Boxing
(November 24, 2014)
Current Members, Family, Friends and Colleagues,
We have entered a new era at TITLE Boxing Club and it is time to come join the fun!
Jennifer Van Heeswyk, Philly Mag's 2012 Female Entrepreneur of the Year has assumed the role of General Manager! Jennifer fell in love with the culture that we have created and is a fitness and healthy life style expert. She has a long history of launching successful businesses and is positioned to take us to the next level!
This means exciting new offerings and experiences for you!!
In the 3 short weeks that Jennifer has assumed the role of GM she has balanced staffing changes while keeping the heart of our core team anchored by Noel, Teion, Tracy and Buttons. As our current members will attest, the vibe and energy in the Club is unlike anything we have experienced to-date!
Whether you are current member or not, it is time for you to come back in and experience this for yourself!
• We have new class schedules
• Corporate and student discounts
• Shorter (30 minutes) classes and longer (a monster 75 minutes) classes
• New Personal Training equipment and rates and
• This week we are offering a Black Friday Special Membership that defers payment until 2015.
I would appreciate it if you would come in, bring a friend or 2, take a First Shot Free and consider joining our (new) TITLE Boxing Club Family.
I am so excited about our future! Come on in and become a part of the new TITLE Boxing Club, Malvern!
First Resource Bank Announces its New Chief Lending Officer and Executive Vice President
EXTON, PA – First Resource Bank is excited to announce the promotion of Lisa Donnon to Chief Lending Officer and Executive Vice President. Ms. Donnon has been working for First Resource Bank for 8 years and brings over 25 years in banking and financial services to her new role with the Bank. Ms. Donnon will manage all loan origination and servicing activities.
Ms. Donnon has a vast array of financing skills in commercial real estate, consumer, construction and dealer financing, which she has acquired over her years of banking experience.
First Resource Bank's President and CEO Glenn Marshall stated, "We are proud to reward Lisa's experience and unwavering dedication with this promotion. We are a community bank that focuses on highly personalized service with experienced bankers. Lisa's addition to our management team will benefit our customers and shareholders."
The bank is expanding its footprint in central Chester County and will be opening an office in West Chester by early 2015. Ms. Donnon's strong lending experience and leadership skills will be instrumental in assisting First Resource Bank to continue its growth in Chester County.
About First Resource Bank
First Resource Bank is a locally owned and operated Pennsylvania state chartered bank, serving the banking needs of businesses, professionals and individuals in Chester County, Pennsylvania. The Bank offers a full range of deposit and credit services with a high level of personalized service. First
Resource Bank also offers a broad range of traditional financial services and products, competitively priced and delivered in a responsive manner to small businesses, professionals and residents in the local market. For additional information visit our website at www.firstresourcebank.com.
Member FDIC.
COFCO Brings an Industry Verteran to the Leadership Team
Dean Molz Joins the Company Bringing More Than 30 Years of Experience to COFCOs Expanding Business
Philadelphia, (July 9, 2014) . COFCO, a premier full service office furniture company and the oldest Allsteel dealer in the country, is pleased to announce the appointment of Dean Molz in a newly]created position, as vice president of business development and member of our leadership team, reporting to CEO Joan Waters.
Molz is an accomplished leader in the industry, most recently serving as Vice President of Business Interiors at Office Basics. During his tenure there, he developed a successful new contract furniture division and built the salesforce for the office furniture side of the business. Molz began his career as a teenager working with his father in their family-owned office furniture business in the 1970fs. He learned the business from the ground up, starting as a delivery boy and developing over the years to become the owner of BF Molz.
Molz will oversee the strategic direction, expansion and operation of business development and sales. A revitalization of the COFCO brand is currently underway which includes; growth, new business development and embarking in new strategic directions that are aligned with COFCOfs core values: authentic, passionate, solutions driven and leadership focused. The focus is on building new relationships, attracting new clients and growing the company.
"I am thrilled that Dean will be joining our team and this is the perfect time," said Waters. "Our future depends on growth and we need a leader like Dean who has built an extraordinary career in the office furnishings industry. He has a proven track record and he brings an innovative leadership style that will benefit us. Dean shares our values and our commitment to building and sustaining relationships that embody trust, accountability, creativity and integrity. He places the same strong emphasis as we do on the client experience. "
"I am profoundly honored to join COFCO in this newly created position and very much look forward to working with the entire COFCO team to advance a new vision," said Molz. "I have always admired COFCO. Their honesty, commitment to quality and longstanding history in the region has made them one of the most reputable companies in the industry. I am excited to help them get to the next level."
Dean has a B.S in Marketing from Stockton University and lives with his family in Moorestown, NJ.
About COFCO, a premier full service office furniture company and the largest and oldest Allsteel dealer in the country. We work with our clients, who come to us from all business sectors, to create workplace environments that make people happy. Started in 1946, COFCO is a privately held company with 45 employees and corporate headquarters located in the American Street Corridor of Philadelphia. For more than 65 years, COFCO has been a leader in the economic growth, viability and sustainability of the community. COFCO is a good corporate citizen and is committed to the environment and supports a green way of life. www.cofcogroup.com
Helen J. Semus Receives Certified Financial Planner Certification
Glenmoore, PA – September 8, 2014
Helen J. Semus, a financial advisor with Ameriprise Financial in Glenmoore, PA recently obtained the CERTIFIED FINANCIAL PLANNERTM certification. Semus successfully completed the rigorous requirements that include course work and a series of examinations covering financial planning, risk management, investments, tax planning and management, retirement and employee benefits, and estate planning.
Individuals with the CFP® certification agree to meet ongoing continuing education requirements and uphold the Code of Ethics and Professional Responsibility developed by the Certified Financial Planning Board of Standards, Inc. Ameriprise Financial has more CFP® professionals than any other firm*.
As a financial advisor, Semus provides financial advice that is anchored in a solid understanding of client needs and expectations, and provides in one-on-one relationships with her clients.
For more information, please contact Patricia Fosbenner at (610) 458 – 8553. Their office is located at 2950 Conestoga Road, Glenmoore, PA 19343 in Ludwig's Corner (intersection of route 100 and 401).
*According to the Certified Financial Planner Board of Standards, Inc. There is no guarantee that you will work with an advisor with a CFP® certification.
Certified Financial Planner Board of Standards Inc. owns the certification marks CFP®, CERTIFIED FINANCIAL PLANNERTM and federally registered CFP (with flame design) in the U.S., which it awards to individuals who successfully complete CFP Board's initial and ongoing certification requirements.
At Ameriprise Financial, we have been helping people feel confident about their financial future for over 115 years. With outstanding asset management, advisory and insurance capabilities and a nationwide network of 10,000 financial advisors, we have the strength and expertise to serve the full range of individual and institutional investors' financial needs. For more information, visit ameriprise.com or http://www.ameripriseadvisors.com/helen.semus.
Brokerage, investment and financial advisory services are made available through Ameriprise Financial Services, Inc. Member FINRA and SIPC.
© 2014 Ameriprise Financial, Inc. All rights reserved.


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The nations of Denmark-Norway, Sweden, France, and the Verenigde Provinciën have signed a formal agreement of peace in the Antilles. The treaty is as limited as possible, to not unduly limit the actions of our captains, yet at the same time protect the borders of each signatory nation. The full treaty can be foundRead more
A limited and temporary ceasefire has been agreed upon with Sweden to accommodate the ongoing diplomatic talks between our nations. The ceasefire only affects the opportunity of each nation to bring conquest flags against the other. The ceasefire is in effect as of June 21st and until negotiations are concluded or broken off. A similarRead more
To all our captains, be hereby informed that our former Dutch allies have now betrayed us. Being allied and supposedly in good standing as recently as yesterday, they have now not only disavowed our alliance, but betrayed it and declared war on us. This is treachery of the very highest order and reveals the untrustworthyRead more
We have ongoing diplomatic talks with the representatives of Verenigde Provinciën. To accommodate those talks and show our good faith we ask that our players drop Dutch players as targets of PvP in the Ile-a-Vache PvP-area. After long talks going into the early mornings we have come to what we consider a friendly understanding withRead more


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Wednesday 11 November 2015
York Theatre Royal's world-famous panto dame Berwick Kaler took to the 'stage' yesterday, when he paid a visit to the building site to see how work is progressing on the theatre.
Box Office Opening Times:
Mon 10am to 5pm
Tue–Sat 10am–8pm**
Sun Closed
*Open until 8pm on show days
**Open until 6pm on non-show days
Theatre Opening Times:
Mon 10am–5pm*
Tue–Sat 10am–11pm**
Sun Closed
*Open until 7.30pm on show days
**Open until 6pm on non-show days
Items from 2015
Wednesday 11 November 2015
York Theatre Royal's world-famous panto dame Berwick Kaler took to the 'stage' yesterday, when he paid a visit to the building site to see how work is progressing on the theatre.
Tuesday 10 November 2015
York Light and York Opera will come together on Sunday 15 November for An Evening of Song, a very special fundraising concert in aid of the York Theatre Royal capital fundraising appeal.
Friday 30 October 2015
York Theatre Royal is to feature in a BBC documentary on Monday 9 November on BBC One, covering the current redevelopment project and this summer's huge community production In Fog and Falling Snow.
Thursday 22 October 2015
York Theatre Royal is pleased to announce that it has been awarded £150,000 by the Clothworkers' Foundation.
Friday 16 October 2015
York Theatre Royal is pleased to announce the full cast line-up for this extraordinary year's pantomime, Dick Whittington (and his meerkat).
Friday 25 September 2015
The theatre is looking for talented girls to take part in the country's most famous pantomime alongside the UK's longest running pantomime dame Berwick Kaler.
Wednesday 23 September 2015
Internationally acclaimed performance company Reckless Sleepers bring their production The Last Supper to York Theatre Royal from Wednesday 7 to Friday 9 October.
Wednesday 16 September 2015
Rehearsals have begun for the latest York Theatre Royal and tutti frutti co-production, Snow Child.
Friday 11 September 2015
York Theatre Royal and tutti frutti are to host their fourth Little Feet festival of children's theatre in June 2016.
Tuesday 08 September 2015
York Theatre Royal is currently part of a new European project, BeSpectACTive!
Friday 14 August 2015
The cast of The Railway Children celebrated the work of much-loved children's author Edith Nesbit on what would have been the writers 157th birthday in the Signal Box Theatre at the National Railway Museum.
Friday 31 July 2015
There's been a replacement to the advertised service at York Theatre Royal's production of The Railway Children this week as panto legend Berwick Kaler has been taken ill ahead of opening night.
Wednesday 15 July 2015
As a thank you to the cast of In Fog and Falling Snow, a seat has been named for them in the new auditorium.
Thursday 02 July 2015
York Theatre Royal is proud to be hosting a new creative collaboration as part of its residency at the National Railway Museum. Days after the world premiere of Last Train to Elvet at Durham BRASS Festival, the production will come to the Signal Box Theatre for two performances on Sunday 9 August.
Wednesday 01 July 2015
Pupils from seven schools in York will tread the boards at the Royal Shakespeare Theatre this month as part of a national celebration of the Royal Shakespeare Company's Learning and Performance Network
Friday 19 June 2015
York Theatre Royal is proud to announce its residency at the National Railway Museum has received an Exceptional Award from Arts Council England.
Tuesday 16 June 2015
The Cast of The Railway Children is Announced
Tuesday 09 June 2015
Find out who some of the cast members are and what they do when not learning lines or going for costume fittings
Friday 22 May 2015
Berwick Kaler's 37th panto to be staged in 1000 seat theatre at the National Railway Museum
Tuesday 21 April 2015
George Costigan cast as George Hudson in In Fog and Falling Snow
Friday 27 March 2015
Cast assemble for the Flanagan Collective's take on Shakespeare classic.
Tuesday 24 March 2015
Calling all adults who would like to take part in a series of free dance workshops and performance opportunity with a professional dance company
Friday 20 March 2015
A wide range of groups and members of the public have donated their time and money and York Theatre Royal is pleased to announce that 94% of the £4.1 million has now been raised.
Wednesday 11 March 2015
Last chance for the public to see inside the theatre before a major redevelopment.
Tuesday 03 March 2015
We are looking for a team of volunteers to help at events around the city.
Thursday 26 February 2015
Tickets for this year's pantomime Dick Whittington (and his meerkat) go on sale in person at the Box Office at 9am on Monday 2 March.
Thursday 19 February 2015
The Rotary Club of York have given a £1,250 donation to the children and young people's group.
Monday 16 February 2015
The Youth Theatre Fundraising Fete on Saturday 7 February was a huge success and raised over £1250 towards the Capital re-development appeal.
Thursday 12 February 2015
Further cast announced for the rehearsed reading of Antony & Cleopatra in aid of the Capital re-development on Sunday 22 February.
Friday 06 February 2015
The writer and director of The Railway Children take part in a Google+ Hangout
Thursday 05 February 2015
Theatre announces total left to raise for re-development
Tuesday 03 February 2015
Auditorium arrives at National Railway Museum for York Theatre Royal summer residency
Thursday 29 January 2015
Friday 23 January 2015
Staff at York Theatre Royal were disappointed to discover the theatre cafe had been broken into this morning and a donations box stolen
Jan 2015 | Feb 2015 | Mar 2015 | Apr 2015 | May 2015 | Jun 2015 | Jul 2015 | Aug 2015 | Sept 2015 | Oct 2015 | Nov 2015 | Dec 2015
2014 | 2015 | 2016 | 2017 | 2018 | 2019


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There are several advantages to being in a couple with someone who belongs to another generation. If you are the younger person in the couple you benefit from your partner's maturity and life experience. This can be a great support in situations where your inexperience could otherwise lead you to mess up.
Meanwhile, the older partner would be wrong not to let themselves enjoy the energy, youth and liveliness of their other half. This isn't to say that it is only the younger partner who is capable of proving their dynamic and vivacious side. Those "of a certain age" get an injection of energy and a quick brush-up on the latest trends! And not only will this give you a boost, but your friends as well. In the end, being constantly in the presence of someone who's younger pushes us to take more care of our selves to make the difference in age less apparent, but also – and this is a big one – to remain pleasing and seductive to our other half. And it's never a bad thing to give ourselves, our appearance and our physical form more attention!
According to sociologists, a new generation emerges every 5 years. In other words, it's every 5 years that a notable, visible change occurs in Western society. However it's every ten years or thereabouts, that habits and attitudes change among people living in the same country. The age gap, which is, as a general rule, above all a strength, can sometimes be a weakness.
It is hard to always be on the same page. One person's maturity can clash with the other's lack of experience. Experience comes up against incomprehension. Often "wisdom" can become embarrassing for the other partner, who finds that they don't "get" what their partner is talking about. This incomprehension at the heart of the couple means that both partners aren't even speaking the same language. For instance, the older partner might spend a lot of time agonizing over the consequences of a relationship with someone younger, while the latter might be solely concerned with living this love as intensely as possible, without spending too much time reflecting on the potential collateral damage involved.
The world is perpetually changing, and this change can seem harder to accept among those who are forty or older. Sometimes mindsets evolve faster among young people which can lead to disagreements. The younger party is often less inclined to respect tradition.
It is not always easy to get in sync with your partner when he or she is ten years younger and seems to never run out of steam. The younger party in the couple will want to go out regularly, go dancing, see a movie, eat in the nicest restaurants or to go on vacation to exciting, noisy locations… whereas the older party's idea of a nice time might be something a little calmer (apart from maybe the first heady burst of the relationship). Clearly, we're generalizing here – these are not rules by any stretch of the imagination – and they are also differences a lot of couples of the same age experience… though we must admit they seem to crop up less often.
The question of children is one that tends to creep up on people. You really must give this nonnegotiable aspect of your relationship some serious thought. A younger man with a partner who is nearing the onset of menopause for example needs to think about this. His partner might find herself unable to offer him the child that he wants. The lack of desire in one partner to have a child as they already have a child of their own is another big one. This is a subject which can't be neglected in a couple. It is at the beginning of a relationship, when you begin to feel that things could become serious, that you need to think about the kids question. Often the future of the couple depends on it.
I could only ever go out with someone the same age as me – it keeps things simple!
I think summer-winter relationships are possible, but they're a lot of work!


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The 'Dallah' is a traditional Arabic coffee pot used for centuries to brew and serve Coffee. The Dallah has been used for by the Bedouins for coffee preparation and serving - a sign of hospitality, generosity and wealth. In much of the Middle East it is still used.
This piece on metal is embedded with hundreds of gems, pearls and Swarvoski crystals. 2.44 x 1.25 meters. Resin coated.


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I've vaguely followed the Eurovision song contest — the nations of Europe choose such varied entries that it's always interesting. But I never expected to see a Benedictine abbot among the contenders. It's happening this year.
Die Priester is one of the 12 finalists who will compete on February 14 to represent Germany at Eurovision 2013. Abbot Rhabanus Peter (Schweiklberg Abbey), Fr. Vianey Meister (another Missionary Benedictine), and Fr. Andreas Schätzle (a diocesan priest from Vienna) carried out an idea that originated with Abbot Primate Notker Wolf and the Cistercian monks of Stift Heiligenkreuz Wallner: to bring the traditional music of the Church closer to the people by presenting it in a 21st century style. Their first CD, Spiritus Dei, was a Top Ten album in 2011. For the Eurovision competition, they worked with soprano Mojca Erdmann.
Want see and hear their entry for Eurovision? Click on this link to go to the video.


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In the light of the above-mentioned details, it is just fair to conclude that despite the sort of kitchen you contend your home and also the style, size, as well as style of range hood you are searching for, the custom copper variety hoods aren't going to disappoint you ever before. Variety hoods come in numerous dimensions, styles, as well as brands. As well as, each kind has both toughness and also weak points.
When picking the best kitchen hood, also think about the simplicity in upkeep and the cost for components replacement. You could talk to sales agents or examine the specifications or handbook to see whether the filters and also components you have to maintain are easy to clean up through basic methods. When cleaned in soapy water, examine if they are made in material that does not corrode. Getting a variety hood with parts that don't break easily as well as cost a lot to change will ready investment.
It is perfectly free of charge to all kind of other furnishings that you may have in your kitchen. There are several various sizes being offered which make sure that you could obtain the one that appropriates for your home kitchen


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About > Our Staff
An important aspect of WISE Kid-Netic Energy is the role models that we provide to Manitoba's youth. Our workshop and camp facilitators are University of Manitoba undergraduate students studying in the Faculties of Science, Engineering, Agriculture & Food Sciences, Nursing, Environment, Earth & Resources and Education. Workshop and camp facilitators are trained in teaching techniques, audience engagement, classroom management, motivational speaking, cultural awareness, and must demonstrate a strong knowledge of science.
Nusraat, Jill, Michelle, Mahalia, Leah and Alex hold down the fort in the WISE Kid-Netic Energy office.
Find out more about employment and volunteer opportunities with WISE Kid-Netic Energy.


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Mcminnville High (MHS) Class of 1997 Alumni List
Help us Update the Mcminnville High 1997 Class List by adding any names missing from the list below:
Registered Alumni
1997 Class List
- Michael Cline
- Jennifer Downes
- Allen Garner
- Travis-Shana Johnson
- Dustin Klaus
- Gustavo Lemus
- Katie Richards
- Joey Rosenost
- Tommy Smith
Know Mcminnville High Class of 1997 graduates that are NOT on this List? Help us Update the 1997 Class List by adding missing names.
The most popular movie of 1997 was Titanic which has grossed over $600,788,188 since its release. The TV series ER was the most popular show of 1997.
Hit Songs From 1997
Mo Money Mo ProblemsNotorious B.I.G.
One More TimeReal McCoy
Naked EyeLuscious Jackson
My Love Is The Shhh!Somethin' For The People
I Don't Want To / I Love Me Some HimToni Braxton
For You I WillMonica
Butta LoveNext
I Finally Found SomeoneBarbra Streisand and Bryan Adams
Look Into My EyesBone Thugs-N-Harmony
I'm Still In Love With YouNew Edition
Hit Movies From 1997
Reunions and Mcminnville High School News
More 1997 alumni from Mcminnville HS have posted profiles on Classmates.com®. Click here to register for free at Classmates.com® and view other 1997 alumni.
Alumni from the Mcminnville High School class of 1997 that have been added to this alumni directory are shown on this page. All of the people on this page graduated in '97 from Mcminnville High. You can register for free to add your name to the MHS alumni directory.
We also encourage you to keep up to date on news and reconnect with Mcminnville High School alumni.


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Package Size: 45.0 * 30.0 * 15.0 ( cm )
Gross Weight/Package: 2.0 ( kg )
Product Name: Silver Satin Dress Homecoming party Dresses
Category: Strapless Wedding Dresses
Package Size: 23.0 * 23.0 * 23.0 ( cm )
Gross Weight/Package: 1.0 ( kg )


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Express. Home of the Daily and Sunday Express.
Fulham 2 - Norwich 1: Martin Jol hopes to seal a Clint deal
CLINT DEMPSEY'S 19th goal of the season underlined once again his importance to Fulham – and manager Martin Jol is now hoping he can talk him into staying beyond his contract, which runs to the end of 2013.
His value as a taker and maker of goals was the reason Fulham claimed a victory they did not deserve.
Norwich striker Grant Holt was absent because of a ban and Norwich might well have earned a point if they had taken some of the chances their bold attacking play earned them in the second half.
Only Wayne Rooney and Robin van Persie have scored more goals in 2012 than Dempsey.
Jol said: "He's our top scorer and that tells you everything. If you have a striker who scores more than 15 in a season you will always be high in the table.
"I hope I can convince Clint that he should stay beyond his contract. The grass is very green at our club and there are not many players who have left Fulham over the years and done well.
"We have offered him an improved deal and now we will wait and see how he reacts to it." Dempsey set up Damien Duff's goal and also hit a post.
If you have a striker who scores more than 15 in a season you will always be high in the table
Norwich boss Paul Lambert brought on Aaron Wilbraham, who promptly hit his first goal in the Premier League and the 100th of a stop-start career.
At 32, he is playing for his future and said: "It feels so good to get a goal in the Premier League and it's like the script was written.
"But the situation now is that you are playing for your career in every game. My only regret is that my goal was not the winner."
It could have been once Norwich sorted themselves out. Lambert said: "We deserve credit for the way we stepped up to the challenge. A lot of people thought we would be among the relegation clubs."
Fulham (4-3-3): Schwarzer 7; Kelly 6, Hangeland 6, Hughes 6, Riise 6; Dempsey 8, Murphy 6 (Diarra 71, 6), Dembele 6; Ruiz 6 (Etuhu 82), Pogrebnyak 5 (Kacaniklic 35, 6), Duff 6. Booked: Etuhu. Goals: Dempsey 2, Duff 13.
Norwich (3-1-5-1): Ruddy 5; Bennett 6, Ward 6, Whitbread 6 (Jackson 46, 6); Fox 6 (Bennett 84); Martin 6, Surman 7, Hoolahan 6, Howson 6, Naughton 5; Morison 5 (Wilbraham 68, 6). Booked: Fox, Ward. Goal: Wilbraham 77.
Referee: A Taylor (Manchester).


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There are a few certainties in life; death, taxes...
...And of course, the cold hard fact that David Hasselhoff - aka The Hoff - is a bonafide legend.
This unequivocal truth was only further emphasised (not that it needed to be of course) after the Baywatch and Knight Rider star took to Twitter in order to congratulate Liverpool and Wales starlet Ben Woodburn on scoring his first goal for his country against Austria on Saturday.
Congrats to Wales !! What A game!and Ben Woodburn ! Nice goal !!— David Hasselhoff (@DavidHasselhoff) September 3, 2017
Not only did the goal prove to be the only strike of the game, it was also a rather special effort:
But however satisfying it must have been for Woodburn to nab the winner - oh, we forgot to mention; not only was it the young lad's DEBUT for his country, his screamer came a mere five minutes after coming on as second-half substitute! - it probably pales in comparison to then having The Hoff commenting about it on Twitter.
You've made it, Ben! 😂 https://t.co/jDyhRG3DTw— Empire of the Kop (@empireofthekop) September 3, 2017
Clearly others agreed with this assessment, if their replies are anything to go by:
You've made it @BenWoodburn— Michael (@Michael_P_C_Lfc) September 3, 2017
@Lord_Napier the hoff knows— JP (@josh_creator) September 3, 2017
You know you've reached the big leagues when the Hoff congratulates you. pic.twitter.com/nljGJYlDLI— Roy O (@cro1) September 3, 2017
But perhaps Terry B summed it up best:


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These are characters designed for Tech Levels of 10 and above, in societies
with spaceflight and generally contact with an alien race or six.
Many of them have their roots in an on-going campaign, which will be reflected in the skills occasionally and the languages frequently. A couple of sets (XenoSolutions and This Way Up) are characters that were used in convention games.
(Characters with a "*" are off-site -- I found them somewhere else.)
Note: though these pages are located at the Steve Jackson Games web-site, the characters contained within are NOT canon! Steve Jackson Games has kindly provided the space for these UNOFFICIAL character sheets, but the responsibility for them is mine and the authors'.
Penelope "Penny" Adair,
Starship Mechanic/Engineer (65 points)
Henry Adames, TL8 "Living Fossil" in TL11 universe (100 points)
Sean Antonelli, TL 10 Ship's Doctor (100 points)
Bill Carnage, survivor of an alien invasion (120 points) *
Janet Deare, TL 11 brainwiped ex-criminal
(100 points)
Peershane Dertaun, Futuristic Psi Time Traveler Kid (360 points)
Detchal, TL11 Kintaran Spacer (115 points)
Jacob Dexter, TL11 Kid With Rich Dad (50 points)
Kevin Dexter, TL 11 CEO of Dexter Shipping (150 points)
Eareelooar, TL11 Sparrial
Security-type (100 points)
Embereyes M'Artemis, Kintaran Apprentice Engineer (100 points)
Lady Erica, Erotic Fashion Designer (200 points)
Erishen ak Carval-ze, TL11 Parvan (Thral) Security Apprentice (109 points)
Simon Evanson, TL10 Starship Security Chief (100 points)
Dr. Benjamin Ficus, Full Eidetic
TL11 Physician (100 points)
Fireback, TL11 Kintaran Shaman (132 points)
Kimi "Gunther" Ferio Tana Gichi-Koo, Cidi Bounty Hunter (100 points)
Scherazade Harami, TL 11 Photojournalist
(50 points)
Stefanie Hardy, TL11 spacer-kid (100 points)
Sarah Hart, TL11 Old Money (25 points)
Andromeda S. Harte, TL11 Rich Kid/Apprentice Captain (100 points)
Silver "Quicksilver" Hawke, TL11 Smuggler/Hot Pilot (100 points)
Storm Hawke, TL11 Intelligence Agent (200 points)
Sadi Hawkins, TL11 "Rock-rat" (Prospector/Miner) (50 points)
Serena Hawkins, TL10 Merchant/Administrator/Computer Expert (100 points)
Serena Hedoni, TL11 Stage Magician (100 points)
Steve Heinrich, TL15 Archaeology Professor/Holovid star (270 points)
Minerva Holmes, TL12 scout/explorer (100 points)
Selene Holmes, TL 10 Sensor/Computer Expert and Astrogator (100 points)
Selene Holmes (timeline B), TL11 Corporate Founder & Electronics Expert (256.5 points)
Selene Holmes (timeline A), TL12 Sensor and Computer Goddess (176 points)
Sherinford "Sheri" Holmes, Private Investigator (100 points)
Shannon Hood, TL11 Freelance Assassin (100 points)
Simone Hospitalier, TL11 Rich Socialite (100 points)
Salome Houri, Professional Courtesan (100 points)
Sandra Houston, TL11 Phone Company Technician (25 points)
Detective Samantha Hunter, TL11 Cop (100 points)
Silvia Hyde, TL11 corrupt Customs agent (25 points)
Howard Jandret, TL10 Planetary
Scout (100 points)
Beauford "Bubba" T. Johnson, Spaceship Mechanic (100 points) *
Colin Kinazcy, TL15 Archaeolgy/Linguistics
grad student (50 points)
Amadi Kipp, TL15 Archeology grad student/quasi-jock (60 points)
Jerry Linco, TL11 Dreamgame Programmer (25
Lorilono, TL11 Sparrial Pilot (120 points)
Karyn MacMillan, TL10 Starship
Pilot (100 points)
Kelly M'Buto, Swiss Army Psi (100 points)
Mecalreealoni, TL11 Irari Doctor (100 points)
Jil Medy, Bioengineered Doctor (168 points)
Pshawn Met-Sho, TL11 Alien Private Investigator (100 points)
Moonfur M'Bat M'Hell M'Artemis, TL12 Kintaran Communications Specialist (240 points)
Aralanoomi Moriarity, TL11 Sparrial-raised Human
George Nakasira, TL10 Starship
Engineer (100 points)
Kyle Nilsson, TL10 "People Person"/Communications Specialist (100 points)
Kitaru O'Donnell, TL10 Starship Captain (100 points)
Parvari, TL11 Fringe-trader Starship Captain (100 points)
Judith Quenton, TL11 Hyperspatial Researcher (150 points)
Races M'Rau M'Clawstripe, TL3 Kintaran
Huntress (110 points)
Red Dwarf characters from the TV show *
Jose Renwar, TL10 Trader/"People Person" (100 points)
William Rowen, TL10 Starship Captain (100 points)
Ryo-ohki, Cute little critter/Werestarship (?? points)
Gaz Scorpio,
Human Astrogation Chief (100 points) *
Shadowflash, TL11 Kintaran Captain (150 points)
Silvie, "Boomer" from Bubblegum Crisis (300 points)
Frank Simmons, TL10 Security Specialist (100 points)
Jacob Smith, TL 10 Psionic Thief (100 points)
Liun Smith, Ultra-tech Mage (343 points)
Toji Smith, TL10 Starship Engineer (100 points)
TL10 Smuggler from Supporting Cast, revised (90 points)
Frederick Song, TL15 Archaeology grad student/ex-scout (90 points)
Anton Spinelli, TL 10 Planetary Sciences Specialist (100 points)
Jesibell "Jessie" Tash, TL
11 Socalite (30 points)
Christina Thallis, Child Prodigy Social Scientist (100 points) *
This Way Up Crew (all 100 points)
T'k'k, Hive Beetle Ship's Engineer (100 points)
James Ulsyn, TL11 News Cameraman (70 points)
Unnamed TL11 ESPer Archaelogist (99.5 points)
Unnamed TL2 Kintaran Shaman (100 points)
Unnamed TL11 Psi Healer/Doctor (100 points)
Koskya "Sky" Vymab, Humanoid Alien Pilot (100 points)
Jeanette Wilson, TL15 Grad student
& sensor operator (65 points)
Aaron Wong, TL 10 Doctor/Life Sciences Specialist (100 points)
Caradoc Wu, TL15 Xenosociology/Archaeology grad student (15 points)
XenoSolutions Crew (all 100 points)


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BOWA's Leadership Program takes high-level leadership concepts and theories and breaks them down into comprehensive modules. Each module contains skills, shared learning experiences, activities, and practical application assignments to launch every participant to the next level of their management and leadership skills.
This training is a unique combination of methodologies and learning styles that keep participants engaged and at peak learning state. We implement props, stories, antidotes, role-playing activities, action learning assignments, lessons, Neuro-Linguistic Programming (NLP) techniques, and even music and video. The sessions are fun, interactive and highly educational. All the trainings are set within a real-world context to keep participants engaged and to help encourage easy application of the techniques from the classroom to real-world situations.
The Program can also include supplemental coaching sessions as a follow up to and in conjunction with the modules. There are also optional as-needed follow-up virtual classes as well.
The Leadership Program was designed to meet the following Learner Objectives:
- Maximizing participants' effectiveness in working together as a team in achieving your organization's strategic goals and initiatives.
- Develop both personal and individual skills and competencies.
- Assist with addressing individual and collective opportunities and challenges.
- Develop leadership skills rooted in research-based concepts and translated for practical application.
- Encourage and enable idea and resource sharing across your organization.
- Build and sustain positive relationships within and across your organization.
- Enhance readiness for new career challenges.
- Increase sensitivity to the needs of clients and enhance customer (internal and external) service skills.
- Increase awareness and expand participants' skills set for addressing diversity for both internal and external audiences.
Participants learn by listening and watching demonstrations, then by trying skills themselves in unique module activities, and then applying the skills immediately in their particular positions at your organization. Participants will be informally and formally assessed (depending on the nature of the skill being honed) in each session. All task completion evidence and documentation will be organized, filed, and presented to your organization's management or program administrators following the program.
The Program is designed for cooperative learning. All participants learn to work as a team, building cross-department relationships and partnerships. Participants learn to depend on each other and look out for each other. This kind of supportive atmosphere will enable all participants to grow in their leadership skills and abilities.
We also stress team-building activities to help people understand the importance of working together. A company is more productive when everyone works together for a common goal, without factions or other divisive elements. These activities help to build a greater appreciation of each other's capabilities and talents through developing a deeper level of understanding and empathy within the group. Team members will come away with a better understanding of not only their decision making preferences but have sensitivity to how their fellow team members prefer to be supported as well.
The Program is designed to boost participants' leadership skills across the Five Leadership Levels: Self Management, Project Management, Personnel Management, Program Management, and Organization Management.
Leadership capabilities build upon each of these levels incrementally. To be a Competent Manager you first but be a Contributing Team Member and before that a Highly Capable Individual. And to be a Good Executive, you first must be an Effective Leader and a Competent Manager. The Program is designed to build upon each of these skill levels in an incremental way across all modules.
BOWA's Leadership Program can be customized to fit your organization's needs.


text:
Ocean Jasper Necklace Back View
The back side of this pendant is a nice little secret for the wearer. The metalwork technique is called piercing, and is done by using a jewelers saw to carefully cut the pattern out of the sterling silver.
©2019 Individualized Adornment. • Powered by pappashop.com
Web Design by


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In Ice Hockey
What is empirical?
The word 'empirical' means 'based only on observation or experiment.' So 'empirical evidence' is evidence that is based on observation. Answer And an 'empirical question' i…s one that can be answered through scientific experimentation. Empirical means: Based on obsevation or experiment, not on theory. Also implies, results acheived by trial and error. ( Full Answer )


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Westlake High (WHS) Class of 2004 Alumni List
Help us Update the Westlake High 2004 Class List by adding any names missing from the list below:
Registered Alumni
2004 Class List
Know Westlake High Class of 2004 graduates that are NOT on this List? Help us Update the 2004 Class List by adding missing names.
The most popular movie of 2004 was Shrek 2 which has grossed over $441,226,247 since its release. The TV series American Idol was the most popular show of 2004.
Reunions and Westlake High School News
More 2004 alumni from Westlake HS Atlanta, GA have posted profiles on Classmates.com®. Click here to register for free at Classmates.com® and view other 2004 alumni.
Missing some friends from Westlake HS that graduated with you in 2004? Check the list below that shows the Westlake Atlanta, GA class of '04.
For former Westlake students from GA, you can view the class reunion information that has been posted by other site visitors. In addition, we encourage you to post your profile in the alumni directory, share information about the school activities you were involved with and reconnect with Westlake High School alumni.


text: I have been wheeling awhile and wrenching awhile. Some of you may remember me as RustyToy. It has been a really long time. I used to work with MuddyPaws and had a rusty Toyota. Now I have a 2001 Range Rover that is my daily/wheeling/tow rig. I can't wait to meet you guys at Drummond.


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Hanover Green have been appointed by Aviva Investors to sell the freehold interest in Quadrant House, Redhill. The 29,500 sq ft office building is offered with vacant possession and provides…Read more
The restaurant will be operated by the Dogus International Group, responsible for or active in seven other London restaurants: Zuma and Roka in Knightsbridge and Fitzrovia, Inko Nito in Soho,…Read more
Hanover Green secure letting to Hello Ltd on Ground to 2nd floors comprising 5,346 sq ft at 34 Upper Ground, SE1 on behalf of Steer Group.
Hanover Green advised Pod Point Ltd on their property strategy looking at relocation options versus staying in situ. This resulted in a newly negotiated lease on their existing premises extending…Read more
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