text:
Leptotrichia spp. are anaerobic, pencil-shaped, Gram-negative rods that are part of the normal oral and intestinal human flora. Although not typically considered pathogenic, invasive Leptotrichia infections have been reported in immunosuppressed patients. A perceived rise in the identification of Leptotrichia spp. at our institution prompted a retrospective evaluation of these infections. Laboratory and clinical records were reviewed to identify Leptotrichia culture-positive patients. Over a 5-year period, 68 Leptotrichia-positive specimens were identified. Of these, 21% (14/68) were identified in original samples submitted from 13 different patients at our institution, and the remainder (79% [54/68]) were unknown isolates referred from outside hospitals for molecular identification. All in-house Leptotrichia were identified from blood cultures. Only 64% (9/14) of these grew on solid media, and 5 were a part of polymicrobial bacteremias containing other enteric pathogens. All local patients were receiving chemotherapy and a majority received hematopoietic stem cell transplant (HSCT) (11/13). All had neutropenic fever with symptoms of mucositis and/or enteritis. Most of the HSCT patients (73% [8/11]) were autologous recipients hospitalized after recent high-dose chemotherapy for multiple myeloma. L. hongkongensis, a novel species, was found in the majority of myeloma cases (63% [5/8]). In conclusion, we suggest that Leptotrichia spp. may be an underappreciated cause of bacteremia, particularly in multiple myeloma patients receiving cytotoxic chemotherapy for autologous HSCT. In our cohort, these infections were associated with neutropenic fever from an enteric source, and most isolates remained sensitive to standard antibiotics.
High-dose chemotherapy followed by hematopoietic stem-cell transplantation (HSCT), is a well-established treatment modality for a variety of hematologic malignancies; however, infectious complications remain a major barrier to the overall success of this procedure. HSCT recipients are at particularly high risk for the development of invasive bacterial infections as a result of regimen-related neutropenia and cytotoxic damage to the oral and gastrointestinal mucosa. Mucositis severity, specifically, is an independent predictor of anaerobic bloodstream infection (BSI) following HSCT (11).
Leptotrichia spp. are fastidious anaerobic, pencil-shaped, Gram-negative rods that reside in the mouths, intestines, and female genital tracts of humans (20). Traditionally considered to be nonpathogenic, Leptotrichia species have occasionally been reported to cause invasive disease in HSCT patients and other immunocompromised hosts (6, 14, 18). The overall incidence of Leptotrichia infections in at-risk patient populations, however, may be underestimated. These organisms are notoriously difficult to recover from blood culture and may retain crystal violet, which can lead to their misidentification as Gram-positive rods. Commercially available phenotypic identification systems also have problems classifying these organisms (12). We routinely use 16S rRNA partial gene sequencing for the identification of anaerobic bacteria (16), which allowed us to recognize an increase in the number of Leptotrichia isolates identified by our laboratory. The purpose of the present study was to evaluate the incidence of Leptotrichia infections identified by ARUP Laboratories over a 5-year period and to review the occurrence of this infection at our institution.
(A portion of these data were presented at the 2010 American Society for Microbiology meeting in San Diego, CA, and at the 2010 Infectious Disease Society of America meeting in Vancouver, British Columbia, Canada.)
Clinical isolates.The Associated Regional and University Pathologists (ARUP) laboratories database was searched for all isolates identified as Leptotrichia spp. between January 2005 and December 2010. Specimen source, Gram stain result, the presence or absence of growth on solid media, and antimicrobial susceptibility patterns (when available) were recorded. ARUP is a national reference laboratory that also operates as the primary microbiology laboratory for the University of Utah Health Care (UUHC) system. Isolated organisms were submitted from outside institutions within the United States for molecular identification, whereas UUHC organisms were identified from primary clinical specimens. Medical records were reviewed for UUHC patients, under a protocol approved by the University of Utah Institutional Review Board. The following clinical information was assessed for adult patients: past medical history, presenting signs and/or symptoms of infection, diagnostic imaging, microbiology results, and antimicrobial therapies.
Blood culture.UUHC patient blood samples were inoculated into one Bactec Plus aerobic bottle (resin media) and a Bactec standard anaerobic bottle (BD, Franklin Lakes, NJ). Cultures were incubated for 5 days in a Bactec 9240 blood culture system (BD) and were monitored automatically every 10 min for the presence of microbial growth. All positive anaerobic blood cultures were analyzed by Gram stain and subcultured on two sheep blood agar (SBA) plates (Hardy Diagnostics, Santa Maria, CA). One SBA plate was incubated at 37°C in an anaerobic chamber, and the second SBA plate was incubated in 5% CO2 atmosphere at 37°C. For samples that did not yield growth on the SBA plate, an additional chocolate and brucella blood agar plate, supplemented with hemin and vitamin K (Hardy Diagnostics), was inoculated and incubated for 5 days. Growth from the anaerobic SBA plate was directly referred for DNA sequencing.
Molecular identification.DNA was extracted from isolated colonies using PrepMan Ultra sample preparation reagent (Applied Biosystems, Carlsbad, CA) according to the kit recommendations. DNA was analyzed using partial sequencing of a 500-bp 5′ region of the 16S rRNA gene as previously described (15). Blood cultures broths confirmed to be positive by Gram stain for bacteria morphologically consistent with Leptotrichia spp. but negative for growth on solid media were directly extracted for sequencing. Briefly, a 1.0-ml volume of positive blood was pelleted at 5,200 × g for 2 min, resuspended in 1.0 ml of sterile phosphate-buffered saline, and pelleted again (repeat twice). The final suspension was then extracted for sequencing as described above.
Antimicrobial susceptibility.Antibiotic susceptibility testing was performed in real-time by physician request using the Clinical and Laboratory Standards Institute (CLSI) broth microdilution reference method for anaerobic organisms (4). In addition, 18 viable isolates were subcultured from frozen storage and analyzed retrospectively. Isolates were tested against a standard drug panel that included ampicillin-sulbactam, cefoxitin, meropenem, metronidazole, penicillin, and clindamycin (Trek Diagnostic Systems, Cleveland, OH). Leptotrichia isolates were also screened for β-lactamase activity using a Cefinase disk (Becton Dickinson Microbiology Systems, Cockeysville, MD). There are currently no established interpretive breakpoints for Leptotrichia spp.; however, antimicrobial susceptibility was inferred based on CLSI breakpoints for anaerobic organisms other than Bacteroides fragilis group (5).
Sequence and phylogenetic analysis.Sequence-based identifications were performed in accordance with the CLSI guidelines (3). For the present study, Leptotrichia sequences were reanalyzed using the most up-to-date version of our 16S reference database (SmartGene IDNS version 3.6.1; Zug, Switzerland). A multiple sequence alignment of our isolates and Leptotrichia type strains was performed using CLUSTAL W in MEGA 5 (17). A phylogenetic analysis was then conducted using the neighbor-joining method with 500 bootstrap replications with MEGA5 software.
Statistical analysis.Statistical analysis was performed using Analyze-It Software for Microsoft Excel (version 2.26). The proportions of patients with Leptotrichia bacteremia were compared using the Fisher exact test for small cell sizes. Summary statistics were used to describe the distribution of Leptotrichia infection at our institution.
Over the 5-year study period, 68 Leptotrichia-positive cultures were obtained from 67 different patients. Most of these (79% [54/68]) were organisms referred to ARUP from outside institutions for molecular identification (Fig. 1). The majority of organisms (91% [62/68]) came from blood cultures. The remaining six isolates came from a variety of sources including: wounds (n = 3), respiratory (n = 2), and amniotic fluid (n = 1).
Leptotrichia microbiology.Seventy-five percent (51/68) of all Leptotrichia were identified to the species level, with L. trevisanii being the most frequently encountered species (47% [32/68]). The remaining species-level identifications included six isolates each of L. wadei, L. goodfellowii, and L. hongkongensis and a single isolate of L. buccalis. Overall, 17 Leptotrichia isolates could only be identified to genus level by partial sequencing of the 16S rRNA gene. Several of these isolates grouped in distinct clades, bearing similarity to L. buccalis, L. goodfellowii, or L. wadei (Fig. 2).
Of the 14 organisms identified from primary specimens at UUHC, 36% (5/14) failed to grow on solid media. All of the nonculturable UUHC Leptotrichia were retrospectively identified as L. hongkongensis. One isolate that failed to grow on initial plating was repeatedly subcultured to several broth (Bactec standard anaerobic ± human blood) and solid (Columbia sheep blood, chocolate, and Brucella blood + hemin + vitamin K) media but was found to grow only in broth containing human blood. Only one multiple myeloma patient in the UUHC cohort had L. honkongensis successfully subcultured from their blood culture bottle to chocolate agar.
Antimicrobial susceptibility testing was performed for 39 isolates (Table 1). The majority appeared highly susceptible to the antibiotics tested, and there was no obvious difference in susceptibility patterns for a particular species. However, two L. trevisanii isolates displayed metronidazole MICs greater than 32 μg/ml, and one of these isolates also had a cefoxitin MIC of 32 μg/ml. A single isolate of L. goodfellowii also had an MIC of 16 for metronidazole. None of the tested organisms possessed detectable β-lactamase activity.
Clinical case histories.In all, 14 cases of Leptotrichia BSI were identified from 13 unique UUHC patients. Approximately a third of cases (36% [5/14]) were part of polymicrobial bacteremias involving other pathogens (i.e., Enterococcus faecium, viridans group Streptococcus, Streptococcus infantis, Bacteroides urealyticus, or Fusobacterium nucleatum). All UUHC patients had received high-dose chemotherapy immediately prior to the onset of bacteremia; twelve had hematological cancers, and one was being treated for a solid tumor malignancy.
More than half of the UUHC hematology patients (67% [8/12]) were undergoing autologous HSCT (auto-HSCT) specifically for the treatment of multiple myeloma. Patients in the myeloma cohort had all been treated with a melphalan-based induction regimen that also included the novel chemotherapeutic agents thalidomide and bortezomib. L. hongkongensis was the most common single species identified from multiple myeloma patients (63%, 5/8). However, the test for association between L. hongkongensis and myeloma chemotherapy for auto-HSCT did not reach statistical significance (P = 0.4).
The multiple myeloma subgroup presented with similar clinical signs and symptoms of infection. All were neutropenic and had fever that was associated with nausea, vomiting, diarrhea, and abdominal pain despite prophylactic oral levofloxacin and fluconazole. In addition, two patients were hemodynamically unstable at the time of hospital admission: one grew L. hongkongensis and viridans group Streptococcus, and the other had L. hongkongensis identified by sequencing directly from the blood culture broth. Of note, one of the hypotensive patients experienced two separate episodes of L. hongkongensis bacteremia following tandem auto-HSCT separated by 3 months. Several myeloma patients (3/8) had computerized axial tomography confirmed necrotizing enterocolitis with negative Clostridium difficile enzyme immunoassay testing from stool specimens. L. hongkongensis was identified in the blood of two of these patients, and L. wadei was isolated from the third. All of the patients in this cohort survived their respective episodes of Leptotrichia BSI, with negative repeat blood cultures following the initiation of empirical meropenem as per our institution's protocol for the management of neutropenic fever.
The remaining five UUHC patients from were receiving therapy for acute myelogenous leukemia (AML) (n = 2), acute lymphoblastic leukemia (n = 1), T-cell-rich large B-cell lymphoma (n = 1), and esophageal cancer (n = 1). Both of the AML patients received allogeneic HSCT, while the lymphoma patient received auto-HSCT. All five patients presented initially for the evaluation of neutropenic fever; however, only the hematology patients had received prophylactic antimicrobials. At the time of hospital admission, all five had severe oral mucositis and were treated empirically with meropenem with or without vancomycin. Unlike the multiple myeloma cohort, only one patient exhibited diarrhea, which was negative by both enteric stool culture and PCR for C. difficile. The Leptotrichia species identified in these patients were variable, with two unspeciated isolates and one of each L. hongkongensis, L. trevisanii, and L. goodfellowii. Like the multiple myeloma cohort, these patients all survived these episodes of bacteremia.
Anaerobic BSIs have increasingly been recognized as an important sequela of high-dose chemotherapy, with severe alimentary tract mucositis identified as a predisposing risk-factor (11). While members of the genus Leptotrichia have been isolated from neutropenic patients (1, 6, 12–14, 19), they likely remain an underappreciated cause of BSI due to inherent difficulties with conventional laboratory identification methods (12).
We observed an increase in invasive Leptotrichia infections at ARUP in 2007, followed by a subsequent rise in our own hospital in 2008. The reasons for this are probably multifactorial. First, regular use of 16S rRNA partial gene sequencing significantly expands the number of anaerobic organisms that can be accurately identified (10, 16). It is also well recognized that Leptotrichia are not reliably identified by a commonly used phenotypic identification system (RapID ANA II; Remel, Lenexa, KS) (12, 14). Furthermore, the number of at-risk patients has also expanded in recent years with the routine use of high-dose cytotoxic chemotherapy for HSCT and the treatment of other malignancies. In recognition of the increasing numbers of auto-HSCT patients admitted with severe mucositis, enteric bacteremia, and sepsis, antimicrobial prophylactic strategies were revised at our institution in 2009. These revisions may account for the subsequent decline in Leptotrichia infections from our transplant center in 2010 (Fig. 1).
Although not generally regarded as drug-resistant organisms, Leptotrichia antimicrobial susceptibility patterns are largely undefined. Our data suggest that these organisms remain highly susceptible to standard agents. Some of the drugs used routinely for prophylaxis or empirical treatment of neutropenic fever, however, lack robust anaerobic activity (e.g., levofloxacin, cefepime, or ceftazidime). Patients with neutropenic oral mucositis and/or enterocolitis are at increased risk for anaerobic infection and should therefore be treated with a broad-spectrum antimicrobial regimen that has anaerobic coverage (9).
Seven Leptotrichia species have been validly described. Of these, L. buccalis and L. goodfellowii were implicated in severe infections, including endocarditis, L. trevisanii, L. wadei, and L. hongkongensis were associated with bacteremia, and L. hofstadii and L. shahii have been isolated from oral wounds (2, 7, 8, 21). It is interesting that, although previously only described as a cause of BSI in two cases (6, 18), L. trevisanii accounted for half of our isolates (32/68 [48%]). It is unclear whether this organism has been regularly identified at other institutions but not reported or whether it is simply not as pathogenic as other species (e.g., L. goodfellowii and L. buccalis). In addition, we identified multiple isolates only to the genus level despite high-quality sequencing results. The phylogenetic analysis does not cluster these isolates within any of the currently described species (Fig. 2), suggesting that some of these organisms may in fact represent previously undescribed species.
Of particular interest was the identification of six cases of L. hongkongensis bacteremia in our UUHC cohort, five of which were isolated from multiple myeloma patients. Although the apparent association between L. hongkongensis and auto-HSCT for multiple myeloma did not reach statistical significance, likely due to our small sample size, the observation is clinically important. L. hongkongensis was only recently described and to date, limited information exists on the clinical spectrum of associated illness (21). Four of the L. hongkongensis sequences in the present study were identical to the type strain (GenBank accession no. EU919515, listed as Leptotrichia sp. strain HKU24) (21), and two were identical to a Leptotrichia sp. isolated from the blood of a patient undergoing treatment for AML (GenBank accession no. AF189244) (12) (Fig. 2). These two clusters of L. hongkongensis sequences were 99.8% identical (differing by only 2 bp) to each other, which suggests that the organism in Patel et al. (12) was most likely L. hongkongensis. Consistent with this notion is the fact that their isolate also failed to grow on initial subculture to multiple solid media. The Patel et al. report (12), in addition to our six cases of bacteremia with L. hongkongensis in a single BMT unit, suggests that this species may be of particular concern in patients undergoing high-dose chemotherapy for HSCT, and its presence may be suggested by the characteristic Gram stain and failure to grow on subculture to solid media. Widespread recognition of these clinical and laboratory observations may lead to better understanding of the incidence of this organism.
In conclusion, Leptotrichia spp. are emerging pathogens in neutropenic patients receiving high-dose chemotherapy. At our institution, there was an apparent association between Leptotrichia BSI and the chemotherapeutic agents used for multiple myeloma patients undergoing auto-HSCT. In particular, L. hongkongensis was shown to be the predominant species in this population, further defining the clinical relevance of this recently described species. Molecular methods have greatly improved the clinical laboratories' ability to identify these potential pathogens, which have fortunately remained susceptible to most antimicrobial agents.
We thank Mary Lampas and Stephanie Sanders for assistance with the medical record review. We thank Keith E. Simmon for his review of these data. We also thank the clinical microbiology laboratory at ARUP for providing antimicrobial susceptibility testing.
- Received 26 September 2011.
- Returned for modification 24 October 2011.
- Accepted 23 December 2011.
- Accepted manuscript posted online 28 December 2011.
- Copyright © 2012, American Society for Microbiology. All Rights Reserved.


text:
There is a picture of Dr. Martin Luther King Jr. that I keep on my desk.
In it, he wears a perfectly pressed black business suit, the portrait of sophistication and class.
The background is a dilapidated house, his childhood home.
The picture captures what King was all about: a new era of justice, bursting from an oppressive past.
What impresses me most about King is not what he amassed—a string of degrees, a beautiful family, worldwide fame, and a name that will live on for generations.
What amazes me most about King is what he gave up—his family, his future, and his very life.
I am amazed that a man who had so much was willing to give up so much, and that in the face of threats (two home bombings and twenty-nine jail cells), he continued preaching, continued fighting. He never backed down.
Where do we see that kind of sacrifice and suffering anymore?
Do we see that kind of sacrifice and suffering anymore?
As a middle-class, college-educated African American woman, a primary beneficiary of King's fight and legacy, I pray that I can continue his dream, not just in what I amass, but in what I'm willing to give up for those suffering at the hands of injustice and poverty.
I pray that I am willing to give my time, my money, and if need be, my very life.
We are, after all, all God's children.
"We must be reminded anew that God is at work in his universe. He is not outside the world looking on with a sort of cold indifference. Here on all the roads of life, he is striving in our striving. Like an ever-loving Father, he is working through history for the salvation of his children. As we struggle to defeat the forces of evil, the God of the universe struggles with us."
-Martin Luther King Jr.,
King Came Preaching

subset: commoncrawl


text:
The pride of Saskatoon, The Sheepdogs personify making it on hard work and determination. Often referred to as 'a talented Nickelback', they formed in 2006 around guitarists Ewan Currie and Leot Hanson, Ryan Gullen on bass and Sam Corbett on drums. Before long the were playing all the hot spots on the prairies and writing some material.
They financed some recording time on their own, and released a pair of indie albums - TRYING TO GROW in '07, and the next spring with BIG STAND. Their blues-based heavy sound prevailed throughout - mixing ZZ Top influences with Nirvana spontaneiety and had them touring the country from coast to coast, pushing heavy hitters like "Waiting For The Morning To Come," "The First Year," and "The Contenders" in what was becoming one of the hardest worked shows on the circuit.
LEARN & BURN in 2010 was certified gold (50,000 copies in Canada), featuring their break-out single, the BTO-reminscent "I Don't Know," which peaked at #2 and #3 on Canada's rock and alternative charts respectively, while earning them their first gold single. The accompanying video also got good airplay at home, while helping establish them Stateside. An old-time boggie handle was spotlighted in the title track, while the lead-off "The One You Belong To" and "I Don't Know" showed an uncanny maturity in a band still so fresh on the scene.
In 2011 they became the first unsigned band (and first Canadian group) to ever make the cover of Rolling Stone Magazine, beating out 15 other groups for the honour. Instantly on everyone's lips and in their ears, they released the Andrew Schlessinger-produced EP, FIVE EASY PIECES that fall, debuting at #7 on the Albums chart in Canada and eventually finding the top 40 Stateside. Another tour that took them across North America with some stops in the UK came on the heel of the single, "Who?"band became little screen darlings overnight, appearing twice that year on "Late Nite With Jimmy Fallon," as well as on "Project Runway" and "The Nieghbour's Dog." "Who?" was also featured in an episode that season of "CSI: Crime Scene Investigation" entitled "Tell Tale Hearts."
They also performed at the Bonnaroo Music Festival in Tennessee and The Osheaga Festival in Montreal (days prior to finding out they'd been chosen for the Rolling Stone gig), and soon they were one of the hottest tickets around while the accolades starting coming. In between road trips with Kings of Leon and Robert Randolph & The Family Band, they picked up three CASBYs (Toronto awards showcase) in 2011 - for Favourite New Artist, Favourite Indie Album, and Favourite New Album. They also picked up Rock Album of the Year honours at that year's Western Canadian Music Awards. The following spring, as well as picking up the Juno for Album of the Year for LEARN & BURN, they also took home the awards for Single of the Year for "I Don't Know," and for Artist of the Year. Unfortunately, they had to have the doorstops mailed to them, as they were busy on tour in Australia with John Fogerty at the time.
After finally signing with Atlantic Records, they began work on a new record (actual vinyl) in Nashville at Haptown Studios with producers Austin Scaggs and Patrick Carney (The Black Keys). The basic tracks were laid in only a few weeks, so they packed up their gear and headed out to several summer festivals, including The Catalpa Music Festival in New York
The single, "The Way It Is," had already topped the charts and was still in the top 30 when their self-titled album was released in September 2012. Critics hailed the record not only for Currie's grunge-tinged gravelly voice being harnessed, but for the bare bones, no frills and even less studio trickery that went into the production. A throwback in every musical sense, the Hammond B3 is unabashed and prevalent on tracks like the lead-off Southern sing-along "Laid Back" and the acoustic "Javelina," while "Feeling Good" was an all-out rollicking stomper. An extended bonus version of the album was available shortly after the original's release, this one with an acoustic version of "The Way It Is" and "Alright OK" and the new "Whocoustic."
They kicked off the tour season shortly after the album's release, touring the American East Coast with The Buffalo Killers.


text:
Broke nozzle?
You was nozzle. Served it to you so to speak faithfully some time. Here suddenly bam - and it breaks. How to Apply in this case? In general, about this article.
Probably it you may seem unusual, but first has meaning ask himself: whether it is necessary general repair out of service nozzle? may more correctly will buy new? I think, has meaning learn, how is a new nozzle. For it possible go to appropriate shop or make appropriate inquiry bing.
So, if you decided their hands perform repair, then primarily sense learn how repair nozzle. For these objectives one may use rambler, or read appropriate forum.
I think this article helped you fix nozzle.


text:
Routing and directions in Maps
Ngân sách $250-750 CAD
I have an application that is Java based (Vaddin framework / CUBA platform) and want to use google or any other suitable maps and API for logistics solution:
Environment: Java web application
Here is the functionalities:
a) Route planning on Maps
-Multi-location stop route planning (waypoints and delay time at each waypoint)
-Round-trip route planning
-Travel time calculation and planning with stop over time
-Suggest alternate routes to cover the selected stops (addresses) and recommend most efficient sequence of stops for the route
b) Geolocation
-Getting geo-location from address database for route planning
c) Mobile navigation
-select the route and start navigation
-Suggest alternate routes to cover the selected stops (addresses) and recommend most efficient sequence of stops for the route
-Actual time should be captured and calculated automatically based on the related client smart phone location
d) Location tracking
-Use list of smartPhone and route assigned
-Tracking location of those different smartphone and monitor the user position in real-time
13 freelancer đang chào giá trung bình $532 cho công việc này
Hi dear Here is a strong experienced Android/iOS developer I have rich experience in google map api I am ready to start to work right now I hope to work with you :) Kind regards
Similar work we have done [login to view URL] [login to view URL] Understanding:- ============ Thêm
Hi there Are there any sign-up/ login functions? Thanks for your time and I look forward to discussing your project in more detail. Best regards. John
How are you? Thank you for your posting project. I fully understood and I think it will suitable with my skills I have many experiences of developing Mobile app. I can do your project and I can start now if you sel Thêm
Hi Good day! I have read your project description and i think my skills are suit for your project development . I have good experience with google map api integration and Geo location app development . If you c Thêm
Hello........ Greetings for the day..... I have read project description and we will be glad to create your application. Since we have done this kind of work before so yes we will be able to do it the best. As Thêm
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Hello, I am an experienced java professional. I have in depth java knowledge. I can create this application. Thanks
I have gone through your project. I would like to know more detail. Is that possible to give a reply back? Thanks, Polus solutions [login to view URL]


text:
Restoration of Lancaster's iconic rocking horse has been a tough challenge as work reveals significant rot to the famous shop sign.
Designer James Mackie has dedicated 20 hours to the ornamental animal which hung over Lawson's toy shop on New Street for many years.
After six sessions the horse's fibreglass had been stripped which revealed the true extent of the rotted pine underneath.
James said: "It took longer than I thought as removing it varied from levering it off in largish pieces, the size of a jam jar lid, to being chipped off in tiny fragments inch by inch with various chisels.
"To be frank, I'm glad it's over but I'm not that chuffed with what I found beneath.
"Some areas under the fibreglass are soaking wet – and some places have rotted right through. As soon as she was stripped back she literally started to perspire. It's not all been gloomy, it was lovely to peel back the layers and find two shiny glass eyes sparkling underneath, and following the lines of the stylised muscles and ligaments with my chisels has been a pleasure."
To be frank, I'm glad it's over but I'm not that chuffed with what I found beneathJames Mackie, designer
The horse also needs a new hinge between its hip and front leg which was damaged by rot.
The next step of the restoration will be the horse's rockers, its base, which is built of laminates of plywood that are benefiting from the fibreglass.
James will replace some parts of these with new marine plywood and then coat those up with epoxy resin to stabilise the whole structure.
These will then be painted in marine quality enamel paints that can be sanded and recoated at regular intervals in the future.
James said: "Anyway, she's breathing again, that's the main thing."


text:
« World's (second) Biggest Soccer Ball? | Main | Google Earth Wins Several Webby Awards »
9 de Mayo 2006
Gulf Impact - Analysis of Damage to Oil/Gas Industry from Hurricanes
GulfImpact.com was just released today by the Timoney Group. Gulf Impact is a powerful demonstration of how Hurricane Katrina and Hurricane Rita affected the Oil and Gas Industry assets in the Gulf of Mexico. Brian Timoney is a GIS professional who really believes in the power of 3D visualization and provides consulting services to businesses interested in reaching the public using Google Earth.
The Timoney Group conducted tests to determine how best to present the data. There are over a dozen layers of data including oil pipelines, oil platforms, gas pipelines, hurricane paths, before/after production rates, and analysis tools. They chose a dedicated web site with an entry choice based on the type of person entering (general audience, energy professional, geospatial professional, or you can see the entire list of layers). The bar graphs showing the 2004/2005 production rates help illustrate just how serious the damage affected the industry. Try turning on hurricane paths and the bar graphs for oil production ('04/'05) for example. I highly recommend visiting the site for the full effect though.
The most interesting tool is the "Buffer Hurricane Paths" tool. This allows you as a user to input how large an area the hurricane paths cut. And another tool lets you input your own path. You simply enter a radius and colors. The server uses GIS tools to generate a new visualization for you and immediately place it back in your GE view. Make sure you read the "Preview" which provides instructions for using this tool. It involves looking at the Places folder after you download the buffer tool, and making a change in the browser window, but is actually quite simple to use. [Note: the Timoney Group reports there are some issues with the buffer tool and the Mac Beta version of Google Earth which they are working on fixing.]
This is a yet another powerful example of how a professional can make dramatic, and useful, visualizations with Google Earth. The Timoney group also produced a visualization for Jonah Gas and a South American Trade demonstration. OgleEarth has conducted an interview with Brian Timoney which is worth reading.
Enviado por FrankTaylor at 9 de Mayo 2006 a las 08:37 AM
Because I am concerned that America is to a large extent funding the Terrorists war against the West by buying so much oil from the East, I was very pleased with the news of last weeks oil discovery in the Gulf of Mexico (Chevron's Jack 2 Well).
Now this mornings news of a magnitude 6 earthquake in the Gulf got me to wondering if and how it might effect the Jack 2 well.
Using the available data from two different articles, I put the JACK 2 well and the M6 quake about 200 miles apart. I think this is pretty darned close!
I would sure be interested in any information and/or thoughts on this matter.
Conrad Driussi
Ridgecrest, CA
Enviado por: Conrad Driussi at 10 de Septiembre 2006 a las 03:32 PM
I was thinking how strange it is that the quake even happened. First I saw that the quake happened 250 miles off the coast of Tampa Bay. Then I remembered how at the end of June, The government released a 25 year ban on oil drilling in the Gulf.
Want to know how far away the oil companies can drill? That's right... 250 miles west of Tampa Bay.
Do your own searches. The truth is being hidden by Big Oil.
When you google info on Chevron's big find... You'll start to realize it's not just Jack #2 that's out there. There is another called the Tahiti Project.... and more coming.
There is no doubt that this rare and unusual gulf quake was caused by tampering with the earth's crust. Chevron drilled almost 30,000 feet into the ocean floor. That's about 5.5 miles down.
It was an earthquake sponsored by Chevron.
Phillip Clark
St Petersburg, Florida
Enviado por: phillip Clark at 11 de Septiembre 2006 a las 05:53 PM
Envíe un Comentario:
NOTA: Use español o Inglés. Los Comentarios son revisados previa publicación.


text:
Transformers (2007)
15 trivia entries
Directed by: Michael Bay
Starring: Anthony Anderson, Hugo Weaving, Jon Voight, Josh Duhamel, Megan Fox, Peter Cullen, Shia LaBeouf, Tyrese Gibson
Trivia: During the highway battle towards the end, a small shot shows the Autobots and Decepticons driving in a wide shot of the entire highway. There is an overhead bridge, on which are standing many people with their cars, as they watch the shooting. Michael Bay, in his director's commentary, said that they were Transformers fans who lived in the nearby area.Anon_Acct
Trivia: When the meteors containing the Autobots crash to Earth, people are running towards the crash sites to see what's going on. One guy with a video camera is saying something like "This is gonna be a hundred times better than 'Armageddon', I promise!". Of course referring to the movie 'Armageddon', a film also directed by Michael Bay. (01:00:10)
Trivia: Director Michael Bay has stated that he decided to make Bumblebee a Chevy Camaro in order to avoid comparisons to Herbie the Love Bug. Indeed, Bumblebee behaves a lot like the Disney movies' Volkswagen Beetle, performing various cheeky actions in the Transformers film reminiscent of Herbie.
Trivia: The "changing sound" that is familiar to all Transformers fans from the TV show, was added to the movie despite opposition from Michael Bay, who wanted a more "robotic" sounding transformation. Hasbro would not license the film unless the director at least stayed true to this one aspect of the TV franchise.Rollin Garcia Jr
Trivia: Peter Cullen, the voice of Optimus in the cartoons, was cast as the voice of Optimus in the movie due to public demand, after it was determined that his voice hadn't aged too much. Frank Welker, who voiced Megatron in the original series, was also in the running for this film, but his voice was now too old to fit the character.Ictoabu
Trivia: According to Michael Bay in the DVD commentary, Optimus Prime's body language was inspired by Liam Neeson.Cubs Fan
Trivia: When Sam kicks Frenzy's head, a "Wilhelm" scream [src] is heard as the little maniac is sent flying into the distance.Super Grover
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You have stumbled on our little corner of the Internet - we have a so much time, so little to do - strike that, reverse it. Stick with us, and we'll make the future an awesome place to hang out. Learn more about Florida Creatives
txt Mondays in July. Because Tuesdays were taken.
An interactive show by acclaimed conceptual artist Brian Feldman, where a mysterious character named txt recites absurdist dialogue written anonymously by the audience in attendance via Twitter.


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Set your seats in the upright position and lock up the serving tray. We have been given the clear signal and we are ready for take-off. The chart of the Dow shows a nice cup-and-handle that looks eerily similar to the one of June - July of last year. The charts these days are like everything else. They are prescribed and sanitized for our comfort. This cup-and-handle is perfect because it is the precursor to the assault on Dow 11,000. We are getting the troops ready and the supply lines established. Next week, we will blow through Dow 11,000 and make our way to the pre-Lehman failure mark of 11,400. Hallelujah! The mountain will soon be conquered and the rest of the world can quit bitching about why the Fed let Lehman fail but saved AIG and Goldman Sachs while carving up Bear for JP Morgan and Merrill for BofA. It didn't seem fair nor did it seem logical to the outsiders looking in. But they were wrong. The new owners of the US had personal stakes in AIG and like the serpent in the Garden of Eden, offered fruit to their Eve in the form of investment banks stripped of portfolio derivative cancers and stock prices pummeled to nearly zero. Who could have passed up that deal?
But there is a price to pay and Eve paid with her soul. So shall we. The central bank now has the world in their hand and a loan contract with everyone's name on it. They own the country. Lest any of us offer resistance, they unleash a security buying program feed by the best printing press in the world. Fiat money is free to print and the Fed more active in the markets than a porn actor in an orgy scene. Their goal is to restore the economies of the world through the ebullience of an ever-rising stock market. The latest 'correction' was a one day dip below Dow 10,000. The Fed arrested that fleeting moment of sanity, as Greece threatened to start an avalanche of debt defaulting throughout the EU thus shattering the pretend asset values of the central banks' derivative 'capital', with a furious and voluminous burst of buying not seen since the days of March of '09. Clearly, Dow 10,000 will not be penetrated again. Now, it is time to take out Dow 11,000. Let the bubble expand!
To support the rise in the market indices, the serpent has polished the apple and let the sweet aroma of the fruit waft underneath the nose of its targeted souls. The US governmental department of pathological lying announced on Friday that the economy gained over 162,000 new jobs in March. Outstanding! My home state of North Carolina and sister state of South Carolina both say that state unemployment is now at all-time highs. But nevermind. We all like the government's story better. It's better for the stock market if we think the economy is growing and adding jobs. Maybe it is. Sadly, in the government's report, the sector adding the most jobs was the government at over 40,000. This seems like a used car salesman driving up sales by buying his own cars. Nevertheless, true or not, the media will be fed a Jack and the Beanstalk story of economic recovery and they will eat it up. Nevermind that local municipalities are laying off teachers, closing libraries, laying off social workers, and cutting salaries because the money isn't there. Ask yourself a question. If the government claims that the economy is recovering, consumer spending is increasing, and housing has bottomed, why then are states and counties taking drastic measures to cut expenses? Shouldn't they be enjoying some tax revenue from a recovering economy, increased consumer spending, and a recovering house and labor market? Where is the money? Maybe the numbers are just fantasy.
The bottom line is this. The Fed knows that they can support their sales job as long as the stock market is rising. And, the stock market will rise as long as someone with a big printing press can shovel money into the beast. Once we all see the shiny apple, we forget about being evicted or foreclosed or unemployed or reduced in salary. We are just stupid and the Fed knows it. Don't you want the shiny apple? We all know what Eve did. I think we all know what investors are going to do. Now is not the time to be prudent, intelligent, or rational. Now is the time to ride the rally. Lock in the serving trays and put your seat in the upright position. We are not just taking off. We are going to Bubble-Land!!!
1.5 years of the Dow ending 4/2/10
Chart courtesy StockCharts.com


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Unrepentant: Man jailed for stealing Mountain of Fire church offering…
by Ogunsakin oluwaseun
An Abuja man has been sentenced to spend a year in prison after being found guilty of stealing from a church.
Ademola Ayeni, 36, had the sentenced passed down on him yesterday after he was convicted on charges of theft for making away with the offerings of the church members.
Ayeni had been previously convicted of the same offence after he stole from the same church last year.
The Magistrate, Khadijat Mustapha, convicted Ayeni, 36, after he pleaded guilty to the offence of theft and did not give the convict an option of fine.
Mustapha said the sentence would serve as a deterrent to those who might want to engage in similar acts.
Earlier, the Prosecutor, Sergeat Simon Ibrahim, told the court that Ojo Oyeyemi of Mountain of Fire and Miracles Church, Utako, reported the matter at the Utako Police Station on November 15.
Ibrahim said the convict criminally trespassed into the church just after they had concluded church service and stole an offering bag containing N50,800.
He said the convict also stole Zenith Bank and Fidelity Bank cheques of N150,000 and N50,000 respectively.
The prosecutor told the court that the convict was a habitual offender and had stolen from the same church in 2012.
Ibrahim said: "He stole from the same church last year.
"He was charged before a different court and was sentenced to one year imprisonment. "In fact, he was just released from prison just last week. "I don't think he is ready to change."


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Rachael Yamagata
When she emerged with Happenstancein 2005, Rachael Yamagata's exotic good looks and boomer-friendly piano-based compositions tempted comparisons to Norah Jones, but her material is actually much more forceful. She continues her quest to convey honest emotions beautifully on her third and latest album, 2011's Chesapeake.
|Event phone:
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|Event website:


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Human rights civic education in Uganda
Published on The New Vision, by staff, 21st August, 2008.
Uganda Human Rights Commission is to start a country wide civic education of masses on Human rights issues. The commission chairperson Margaret Sekagya says the civic education is aimed at creating awareness about the rampant human rights cases in the country … (full text).
More about Human rights in Uganda:
- on HRW in Uganda;
- on wikipedia;
- on Self Help Africa;
- on Student World Assembly.org;
- on UN Foundation;
- on Human Rights Uganda;
- on UNDP: Commission of Legal Empowerment;
- on GayRights Uganda;
- on Amnesty International USA;
- on Human Rights Network, Uganda;
- on Foundation for Human Rights Initiative;
- on ILO: The Uganda Human Rights Commission UHRC.


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Monday, 17 April 2017
'BE CONTENTED': People in my community.
What do you have presently? What are you so desperate to have?
You ought to be grateful to God because of what you have which many do not have up to what you have.
Paul told Timothy that if he has food and clothing, he should be satisfied with it. When a man is discontented with what he has or with what God has given him, he'll be covetous and become an ingrate.
Being contented doesn't mean you shouldn't ask God for what you want (Matt. 7:7), it only means that you should not join the rat race of aiming to have it at all cost.
Being content makes you live a worry-free life. You won't have to be worried for what you do not have yet, but you'll be grateful for your present state while hoping for the change you want.
As a child of God, your ability to have other things that you need is to seek first His kingdom and righteousness (Matt. 6:33). You'll become much more depressed when you pursue material things yourself instead of allowing God to give you as at when due.
Lack of contentment makes you compare yourself with others (2 Cor. 10:12). However, no two destinies are the same and God has a different timing for each lives.
Contentment is an art you must learn regardless of any situation you find yourself in. If you want more, pray more and work hard. Don't look for shortcuts to wealth. Don't be covetous because lack of contentment is a pathway to frustration in life.
By Adeniyi Tim Oluwamayowa.
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Heartland Hospice Patient Receives a Quilt of Honor
Heartland Hospice serving Southeastern Wisconsin presented patient, James Shawlin, with a Quilt of Honor during a special ceremony. "As a partner of the We Honor Veterans program, Heartland Hospice is committed to caring for and honoring those who have served," explained Volunteer Coordinator, Emilee High. "The mission of the Quilts of Honor organization is to bestow a universal symbol and token of thanks, solace, and remembrance to those who served in harm's way to protect and defend our lives and freedoms. Presenting a quilt is just one of the many ways Heartland gives thanks to our veteran patients," added Emilee.
Mr. Shawlin enlisted in the Navy in 1955 and actively served for 30 years, which included more than three years in Vietnam as a patrol officer. He was awarded two Purple Heart medals for his service. After his time in Vietnam, Mr. Shawlin took on various positions, including the very difficult job of serving as a Casualty Assistance Calls Officer – personally visiting families to deliver the news that their loved one died serving their country. He also travelled to Chicago, Scotland and Hawaii, among other places. Mr. Shawlin continued on to teach Naval Science at Marquette University and ROTC at Bay View High School both in Milwaukee, WI. He retired in October of 1985.
Along with Emilee, Heartland team members, Lisa Servais, social worker; Jackie Konkol, RN case manager; and Colleen Fechtmeyer, team coordinator helped to plan a special ceremony that included the presence of the Shawlin family and some of Mr. Shawlin's favorite treats – root beer and mini-cupcakes! However one of the most touching moments happened when Commander Tim Baranzyk, a fellow Vietnam veteran, from the American Legion Post 416 in Greendale, WI, came to offer his camaraderie, appreciation and a hug.
"It was an extremely memorable and emotional afternoon for all. Many of Mr. Shawlin's family members had never heard his stories from Vietnam before, so this event provided an unforgettable moment that will live on in the hearts of his family forever," explained Lisa.


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Having evolved further, our component type Harmonic Drive® have re-emerged in a more compact and easier-to-install configuration.
Component type CSF series Harmonic Drive® have been developed to meet the needs of the industry as they concern space saving, cost efficiency and other performance characteristics at a time when demand for such features are increasing in tandem with the accelerated pace of technological innovation. The CSF series Harmonic Drive® offered here can be directly integrated into your machinery/equipment. With the addition of a 1/30 reduction ratio series, our Harmonic Drive® have made their debut in an even richer line-up so you can select the unit that is most suitable for your needs.
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Ethical Dilemmas in Competency for Execution EvaluationsJournal of Forensic Psychology Practice
Document TypeArticle
Publication Date1-1-2005
- Competence,
- Ethics,
- Execution,
- Medication,
- Mitigation
AbstractSince the United States Supreme Court Ruling in 1986 that ruled that it was unconstitutional to execute "the insane," psychologists have struggled with the problem of what, if any, role they should have in evaluating and/or treating inmates on death row. Those defending such evaluations maintain that psychologists are merely doing a psychological evaluation, not determining the outcome. Those opposed to such evaluations contend that psychologists cannot separate themselves from the consequences of their evaluations. This article will explore these perspectives, raise relevant ethical issues, and suggest an alternative role for psychologists in capital sentencing proceedings.
Citation InformationDavid L Shapiro. "Ethical Dilemmas in Competency for Execution Evaluations" Journal of Forensic Psychology Practice Vol. 5 Iss. 4 (2005) p. 75 - 82 ISSN: 1522-8932
Available at: http://works.bepress.com/david-shapiro/42/


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text: Electric Fan Death Ste Wilson Manchester 'Electric Fan Death' (EFD) is the music maker alter ego of Ste Wilson. Releasing alternative music that crosses genres for the general airwaves and for indie games. EFD is currently working on a soundtrack to The Flawless: Art's Tale (TFAT) for Bare Knuckle Development. Check out the games progress at: http://www.bareknuckledev.com #flawlessthegame History: Formed in South Korea in 2009 and released the debut EP 'Yeosu Dangerous' as a duo with Ollie Philpot. Ollie left in 2010. EFD went on to release the track 'Bleed Blood Bled' as a solo artist, Ste Wilson. EFD is now working on music for the indie game The Flawless: Art's Tale along with other tracks. Electric Fan Death's tracks Maybot Run Theme by Electric Fan Death published on 2017/09/30 15:00:10 +0000 Bleed Blood Bled by Electric Fan Death published on 2012/06/24 23:49:19 +0000 Wayguk by Electric Fan Death published on 2011/01/18 05:22:02 +0000 Landmine by Electric Fan Death published on 2011/01/18 04:38:26 +0000


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Looking for something cool to serve in small, elegant glasses on a warm evening? This lovely mix of fruits, almond and chocolate will make your heart sing and your eyes flutter. Promise. Continue reading
Tag Archives: cherries
YOUR HEALTHY PLATE: Brussels Sprouts Slaw
When you hear about a recipe for cole slaw, you usually think about cabbage. The "cole" in cole slaw" actually refers to cabbage, and it's related to the "kohl" in kohlrabi, as well as the "col" in colcannon, that delicious Irish dish of cabbage and potatoes. Like Brussels sprouts, kohlrabi and cabbage are members of the Brassica family of vegetables, also known as crucifers. Continue reading


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Yahoo! Business Insider
Homebuilding giant PulteGroup reported Q3 net income of $117 million or $0.30 per share. This was a big improvement from last year's $0.34 net loss.
Analysts were looking for just $0.20 per share.
Net new orders jumped 27% to 4,544 homes.
In the company's press release, CED Richard Dugas reiterates his bullishness on housing. But he also emphasizes its impact for the rest of the economy:
"The quarter also showed a continuation of the stronger housing demand we have been experiencing since the start of 2012, as PulteGroup's 27% increase in year-over-year signups was generated from 78% fewer communities. Although still well below historical levels, the U.5. housing market has realized a meaningful increase in the volume of new home sales for the first nine months of so 12.
"In past cycles, the U.S. housing industry proved to he a powerfill engine that could help drive the economy forward and accelerate the pace of a recovery. A similar scenario could again he unfolding, as the industry is responding to increased sales by hiring additional workers and purchasing more building materials . "While we are mindful of any potential impact from global or domestic economic issues, we are optimistic that the combination of ever higher rental rates, record low interest rates and limited housing supply can continue to support the housing demand Within this environment, we continue to invest in the business appropriately, including having recently increased our approved 2012 land spend by $90 million to approximately $1.0 billion, while remaining focused on improved returns."
That's pretty bullish.


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i havent posted in awhile !!! i bought a new camera and i figured i… - ~~~ BOSTON BUDDIES ~~~
Why Have a Dog When You Can Have a Boston Terrier?!?!?!
17 June 2009 @ 07:47 pm
4 Chew Toys —
avintageidea on June 18th, 2009 05:47 am (UTC)
aww, what a cutie!
bostonsnboxers on July 7th, 2009 01:48 pm (UTC)
Great pic! What kind of camera did you get?


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Dear Body:
YOU CAN DO THIS! You have been working hard and strengthening yourself for months. You have been fueled well, and rested this week. With all this in mind, I do however have a few requests/orders:
First, please save the cramping for after the finish line. In exchange, I will be sure to supply you with the electrolytes you need and give you a great stretch before and after the race.
If at all possible, could you speed up the movement of blood and lactic acid out of my quads after the bike? Waiting seven minutes and four seconds to feel like my legs are working again is a bit long and, frankly, unnecessary. It also causes me to grimace in pain/annoyance and I really don't want that captured in any pictures from the event. And, speaking of photos, if you could turn just so to hide my muffin top when near any functioning cameras, I would greatly appreciate it!
Please save the glute pain until after the race. Running with my hand on my left glute chanting "I have a pain in my behind" is not the best approach to a positive race.
Unfortunately, use of restrooms between the transfer of the time chip to me and my crossing the finish line is strictly prohibited, so please plan accordingly. And, while we are on that topic, I am fully aware that I have had three children within 5 years. Therefore, the constant reminder through "bladder challenges" (yeah, THAT) is not necessary, so please conduct yourself accordingly.
Move and move fast. And I don't just mean the arms. If the legs could somehow reflect the speed with which the arms pump during the run, it would be much appreciated.
Don't fall. Enough said.
Most of all, enjoy! And, if you happen to forget any of these items, I will remind you loudly and often during the race to assist you with meeting these requirements.
Dear Mind:
YOU CAN DO THIS! Any thoughts to the contrary are strictly prohibited. Don't worry about the Body, it has also been informed of this, but DO provide encouragement as needed. With all this in mind, I do have several requests/orders:
The only vision you may have of the left turn on the bike course is one of the Body sailing through it with just the right lean and speed necessary. All other visions are strictly prohibited and "turned off" pursuant to THIS theory/instruction.
DO NOT think about those behind you and wanting to pass you on the bike course. Leave it up to them to worry about that. This is as much your race as it is theirs, so concentrate on yourself.
If, and only if, something doesn't go as planned, adjust and let it go. DO NOT obsess about things you cannot change.
Stop worrying about whether you look like a dork. You may well just look like a dork, but you are you, and most people aren't even going to notice - they are worried about looking like a dork too, so they are too focused on themselves.
Replace the thought "I don't know if I can do this" with "I AM doing this!" Why? Well, because you ARE doing this.
Enjoy! You have wanted to do this for a long time and have had the privilege to prepare for it, so enjoy, LOVE it, and worry about tomorrow tomorrow!
Don't worry, if you forget any of this along the way, I WILL remind you loudly and often.
*and if you pass me on Saturday and hear me reminding my body and mind about these things, just smile and laugh WITH me, not AT me! Good Luck to all racing this weekend!
Friday, July 1, 2011
Dear Body, Dear Mind
Posted by brickstrainingmomma at 10:17 AM
Labels: Confidence Limit, Humor, Mental Training
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Cast your vote before 6 pm MST. That's when balloting in our unique on-line poll closes! Pick Your President here.
Clearly New Mexico is participating with six other non-partisan organizations who are surveying folks in their states — California, Colorado, Michigan, Ohio, Washington and Wisconsin (polling both Democratic and Republican candidates).
Iowa and New Hampshire have had their say — and the results shocked the pundits!
With the race unusually tight in both parties, the choice that New Mexicans make may well decide the nominee on both sides of the aisle.
In fact, throughout its history New Mexico has served as a national bellwether. Since achieving statehood 96 years ago, New Mexico has gone to the national popular vote winner in every election except for one. That was 1976 when the Land of Enchantment gave Gerry Ford the nod.
That's why your vote matters more now than at any time in the last twenty years. And that's why Clearly New Mexico is participating in a unique online poll.
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So cast your vote here right now and then ask your friends to do the same.
This evening (January 18) Clearly New Mexico will announce the winner of this special New Mexico poll.
Until then, candidate rankings will be updated frequently, so you'll be able to track your candidate's progress by refreshing the "Results" page often.
Please pick your president now and then spread the word: