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An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 37062
Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved 'invasion suppressors'.
RNAi line: 37062 (III)
Source: VDRC
Name: fkh (1)
Full name: fork head
Also known as: Sebp2
Annotation symbol: CG10002
FlyBase ID: FBgn0000659
File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)
External URI
- Metastasis
- Cancer -- Molecular aspects
- Cancer -- Genetic aspects
- Neoplasm Metastasis
- Molecular Biology
- Neoplasms -- genetics
- Drosophila, cancer, invasion, metastasis, screen, RNAi, lgl, tumour suppressor, invasion suppressor
- Biological Sciences::Zoology::Cell zoology
- Biological Sciences::Biology::Cell biology
- Biological Sciences::Genetics::Medical & veterinary genetics
- Q Science::QL Zoology::QL360 Invertebrates
- Q Science::QH Natural history. Biology::QH426 Genetics
- Q Science::QH Natural history. Biology::QH201 Microscopy
- R Medicine::RC Internal medicine::RC 254 Neoplasms. Tumors. Oncology (including Cancer)
- University of Nottingham, UK Campus::Faculty of Medicine and Health Sciences::School of Life Sciences
Deposit date
2019-05-10Data type
Image filesContributors
- Canales Coutino, Brenda
- Cornhill, Zoe E.
- Couto, Africa
- Mack, Natalie A.
- Rusu, Alexandra D.
- Nagarajan, Usha
- Fan, Yuen Ngan
- Hadjicharalambous, Marina R.
- Lourdusamy, Anbarasu
- Castellanos Uribe, Marcos
- May, Sean T.
- Rahman, Ruman
- Cancer Research UK
Grant number
Collection dates
- October 2012 - April 2017
Data collection method
Live imaging was performed with either a Leica SP2 inverted confocal microscope equipped with a × 40/1.25 NA oil objective with PL APO correction, a Zeiss LSM880 inverted confocal microscope equipped with a x 40/ 1.30 NA oil Ph3 M27 objective or a Zeiss LSM5 Exciter AxioObserver equipped with an EC Plan-NeoFluar × 40/1.30 oil lens. Z-series were acquired using 1 μm z-sectioning.Resource languages
- en


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Title Insurance
It's not something clear and obvious, so people tend to ask, "What is title insurance?" A home is usually the largest single investment any of us will ever make. When you purchase a home, you will purchase several types of insurance coverage to protect your home and personal property.
Homeowner's insurance protects against loss from fire, theft, or wind damage.
Flood insurance protects against rising water, and a unique coverage known as
Title insurance protects against hidden title hazards that may threaten your financial investment in your home.
Protecting Your Largest Single Investment
Title insurance is not as well understood as other types of home insurance, but it is just as important. You see, when purchasing a home, instead of purchasing the actual building or land, you are really purchasing the title to the property – the right to occupy and use the space. That title may be limited by rights and claims asserted by others, which may limit your use and enjoyment of the property and even bring financial loss. Title insurance protects against these types of title hazards.
Other types of insurance that protect your home focus on possible future events and charge an annual premium. On the other hand, title insurance protects against loss from hazards and defects that already exist in the title and is purchased with a one-time premium.
Title Insurance Types
Owner's coverage
Owner's title insurance lasts as long as you, the policyholder – or your heirs – has an interest in the insured property. This may even be after you have sold the property.
Depending on local practices and state law where the property is located, you may pay an additional premium for an owner's policy or you may pay a simultaneous issue charge – usually a smaller amount – for the separate lender coverage. You may even split settlement costs with the seller for the lender or owner's policy.
Lender or mortgagee protection
Most lenders require mortgagee title insurance as security for their investment in real estate, just as they may call for fire insurance and other types of coverage as investor protection. In fact, title insurance is so powerful, lenders are typically willing to make mortgages in distant locales where they know little about the market as long as the buyer has Title Insurance. All that and pennies on the dollar.
What does Your Premium Really Pay For?
An important part of title insurance is its emphasis on risk elimination before insuring. This gives you, the policyholder, the best possible chance for avoiding title claims and loss.
Title insuring begins with a search of public land records affecting the real estate concerned. An examination is conducted by a title agent or attorney on behalf of its underwriter to determine whether the property is insurable. The examination of evidence from a search is intended to fully report all "material objections" to the title. Frequently, documents that don't clearly transfer title are found in the "title chain," or history, that is assembled from the records in a search. Here are some examples of documents that can present concerns:
Deeds, wills and trusts that contain improper wording or incorrect names
Outstanding mortgages and judgments, or a lien against the property because the seller has not paid his taxes
Easements that allow construction of a road or utility line
Pending legal action against the property that could affect a purchaser
Incorrect notary acknowledgments
Through the search and the examination, title problems are disclosed so they can be corrected whenever possible. However, even the most careful preventative work cannot locate all hidden title hazards.
Hidden Title Hazards – Your Last Defense
In spite of all the expertise and dedication that go into a title search and examination, hidden hazards can emerge after closing, resulting in unpleasant and costly surprises. Some examples of hazards include:
A forged signature on the deed, which would mean no transfer of ownership to you
An unknown heir of a previous owner who is claiming ownership of the property
Instruments executed under an expired or a fabricated power of attorney
Mistakes in the public records.
Title insurance offers financial protection against these and other covered title hazards. The title insurer will pay for defending against an attack on title as insured, and will either perfect the title or pay valid claims. All for a one-time charge at closing.
Your home is your most important investment. Before you go to closing, ask about your title insurance protection, and be sure to protect your home with an owner's title insurance policy.

subset: commoncrawl


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Item Number: WB-90
Printed on-demand; 99% ship in 48 hours!
Bow-headed WindBlade Pole Banners are designed to stand tall in front of your store and stay open even without wind. Vibrant, dye-penetration printing for see-thru viewing on super-strong, 3.8 oz, reinforced knitted-polyester material. Banner slides easily onto required pole with rotating ground-stake (sold separately) and sticks securely into ground - no installation tools required. Choose from 12 FT or 15FT. Wall-Mounts also available (sold separately). INSTALL NOTE: AT LEAST 1 POLE KIT IS REQUIRED (SOLD SEPARATELY). 99% ship in 48-72 business hours.


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What Makes Us Unique
Most dojos (Japanese term for "school" or "training hall") offer group classes only. What makes us unique is our Dynamic Mastery Method of Instruction™ - world-class private instruction combined with age-specific group classes.
This format allows us to customize our programs to fit your age, skill, physical abilities and goals. This combination also allows students to learn and earn belt ranks at their fastest, most efficient speed instead of only learning as quickly as the slowest person in the group.
Modern Self Defense Style with Historical Roots
"Ultimate" Kenpo is a blended style that takes the "best of the best" from Karate, Kung Fu and Jiu Jitsu and combines it into one system that works in almost any situation and is adaptable to any body style.
This combination of the Classical, Practical and Tactical aspects from each style forms a system that teaches you how to defend yourself on your feet or on the ground; empty-handed or against a weapon.
Age-Specific Training Curriculum
In addition to our ability to customize our program to fit your unique needs, goals and abilities, our classes are also separated by age. While many dojos mix age groups, we separate ours so we can tailor the instruction to the needs of each age group.
With Z-Ultimate, the focus of the training and how the material is taught is different, depending on the age of students.
Safe, Clean, Family-Friendly Studio
Our location is safe, clean and family-friendly with a warm, inviting atmosphere. Our dojo is a place where students of all ages and skill levels can come together and feel comfortable pushing themselves to be their best.
Over time, many students and parents come to view the structured environment of the dojo as a home-base as they discover the benefits of martial arts training.
#1 Total Body Wellness Program for Adults
Our adult karate classes teach invaluable, life-saving skills and get you what we call, "functionally fit". Along with the many physical benefits of training, you will experience a growing sense of calm and confidence that comes from pushing yourself past old, limiting beliefs about who you are and what you are capable of. With an increased level of focus, drive and self-discipline, you will see improvements in other areas of your life, too.
From former athletes looking for new challenges, former Military, busy executives and business owners to working parents, stay at home parents, Baby Boomers and even grandparents - our program is one of the most challenging and rewarding things anyone will ever do.
Building Confident Karate Kids
The #1 gift a parent can give their child is something our Karate for Kids program instills in every one of our students - confidence.
By developing self-confidence, children learn to be resilient; they develop mental and emotional toughness along with an, "I-will-never-quit" mentality.
Our program will also develop their focus, listening skills, body control, balance, coordination, motor skills and social skills. Our training helps children with hyperactivity, physical challenges, behavioral issues, learning disabilities and other traits that may have held them back in the past.
A common misconception is that putting a child in our program will make them aggressive or turn them into a bully. The reality is our program helps get children into balance. Bullies learn empathy, shy children come out of their shells socially and hyperactive children become more calm.
One of the first rules every single child learns when they start training is, "Keep your punches and kicks to yourself." Children are taught the only time to use their new skills is training at the dojo, practicing at home or if they have to defend themselves (which we all hope they never need to do.)
Fits Into Any Busy Schedule
Because we offer a combination of private and group training, our program is easy to fit into any busy schedule. Private lessons are available by appointment so you can schedule them any time. Group classes are offered six days a week.
For convenience, you can pick a set time each week for your private training, so it is easy to schedule and remember. For group training, you can pick the same class times each week or vary the times if it is easier on your schedule.
Come See for Yourself What Our Program Is Like - FREE
The best way to truly understand the power of self defense training is to experience it for yourself. Many people are unsure if our program is for them, if it will really help them or their child, or if they have what it takes to earn a Black Belt.
This is why we created the Free 30 Day Test Drive with No Cost, No Obligation. We want you to be able to see for yourself - and FEEL for yourself - what it is like to experience the power of personalized classes.
Take a moment and fill out the form below; from there you will be taken to a form where you can schedule your first class online. After you register for your first class, you will be contacted by someone from the studio and you will get an e-mail confirmation, along with some pointers for your first visit.
Thank you - we look forward to meeting you!
Location Information
Z-Ultimate Self Defense Studios Oak Park
Email: firstname.lastname@example.com
Monday | 12:00 PM - 9:00 PM |
Tuesday | 12:00 PM - 9:00 PM |
Wednesday | 12:00 PM - 9:00 PM |
Thursday | 12:00 PM - 9:00 PM |
Friday | 12:00 PM - 9:00 PM |
Saturday | 9:00 AM - 3:00 PM |
Sunday | Closed |
- Z-Ultimate Self Defense Studios Oak Park


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Vintage Travel Poster
- Original Limited Edition - By Living Artists / Not AI Generated
- Worldwide Free Shipping from UK, USA, UE, Canada & Australia
- Printed on Order in Fine Art 12 giclées on EMA paper 200gsm
Immerse yourself in the captivating beauty of Garraf Beach with this exclusive Catalunya travel poster by French artist Alecse. This stunning piece of art captures the serene charm of the Spanish coastline, featuring the bustling beach and striking mountainous backdrop. Perfect for avid travelers, art lovers, and those with a connection to this picturesque region, it brings a touch of Catalonia's coastal splendor to any space. Available in 7 sizes and part of a limited edition series of 300 prints, this poster adds a unique and premium-quality element to your collection.
Garraf Beach, nestled along the Catalonia coastline, is renowned for its golden sands, turquoise waters, and charming seaside village. This poster beautifully depicts the lively beach scene, with sunbathers, colorful umbrellas, and the iconic rocky cliffs in the background. The vintage-style title "Garraf" and "Catalunya" enhance its travel poster appeal, making it a perfect centerpiece for any room.
Alecse's artwork is celebrated for its soft focus style and vibrant colors. This Garraf Beach travel poster features a harmonious blend of blues, greens, and earthy tones, capturing the natural beauty of the beach and surrounding area. The subtle shading and texture create a dreamy, inviting quality that draws the viewer into the scene.
This poster makes a thoughtful and unique gift for anyone who loves Catalonia, whether they live far from home or have fond memories of visiting. It's perfect for housewarmings, birthdays, or special occasions, offering an original and artistic touch to any decor. Emphasizing its limited edition status, this print is a rare treasure that combines artistry and exclusivity.
- Original Certified Limited Edition Travel Poster by Alecse
- Exhibition-quality HD print 12 giclées printers (Fine Art)
- Matte Finish on Thick Premium-grade EMA paper (200gsm)
- Available in 8 sizes for a total of 300 prints ONLY
- Art Print only: Frame/Panel sold separately
- Free worldwide shipping with tracking
- Production time: 2 business days
- Rolled and packaged in a carton tube for maximal protection
- Satisfaction guaranteed: Damaged or defective posters are replaced
Printed upon order with a zero-waste commitment, our posters embrace sustainability from concept to delivery. Dispatched within 48 hours, they journey from our eco-efficient partner's labs in the Netherlands, UK, USA, and Australia, ensuring minimal carbon footprint and expedited arrival*.
Crafted for longevity, not landfills, each poster promises enduring elegance in your home or as a thoughtful gift.
Garraf Poster Beach, Catalonia Travel Poster by Alecse™ © MyRetroposter,2017-2024.
*MyRetroposter is not responsible for any customs duties, import taxes, or delivery delays caused by courier services. Please review our full disclaimer prior to placing your first order.
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What Is the Half-Tone Effect in Alecse's Travel Posters? How does it differ from pixelization?
Alecse's Original Travel Posters are celebrated for their unique half-tone render, a signature style that plays a crucial role in their appeal and authenticity. This distinctive digital effect is intentionally used to mimic the old poster printing process, where colors were rendered by the juxtaposition of dots of different sizes and colors. This method is a nod to vintage aesthetics, giving each poster a classic, retro look that aficionados of vintage travel and retro posters appreciate.
Half-Tone vs. Pixelization:
- Half-Tone is an artistic technique used to create shading and texture effects in images. It involves the arrangement of dots of varying sizes and spacing to simulate different shades of color. This technique was traditionally used in the printing industry to reproduce photographs and illustrations with a limited color palette, contributing to a poster's vintage appearance.
- Pixelization, on the other hand, refers to an effect seen in digital images when they are enlarged beyond their resolution. This results in the individual pixels becoming visible, making the image appear blocky or mosaic-like. Pixelization is often considered a flaw or limitation of digital images, unlike the half-tone effect, which is a deliberate artistic choice.
The posters by Alecse™ are printed in Fine Art 12 Giclées, ensuring high-quality reproductions that honor the original artistic intent. While these art prints are not meant to be crisp like photographs and intentionally include blurs and vintage effects, it's essential to distinguish these artistic choices from potential printing defects. A clear indication of a print's quality is the crispness of the signature and titles; if these elements are not sharp, it may indicate a printing issue.
For those interested in the intricate details of Alecse's work or wanting to appreciate the half-tone effect fully, we offer the option to receive a close-up picture in High Definition before placing an order. This allows customers to make informed decisions and ensures satisfaction with their purchase of vintage travel and retro posters, enhancing their collection with pieces that truly represent the artist's vision and the era's printing techniques.
Please contact us if you wish to receive a close-up picture in High Definition before placing your order.
What Makes Our Retro Posters Exhibition-Quality?
Every poster at Myretroposter.com is meticulously produced from the artist's master file. The dimensions of this master file consistently align with the largest size we offer, maintaining a resolution of 300 dpi. This meticulous process guarantees that each art print is a flawless reproduction, capturing the essence and detail envisioned by the artist.
Our commitment to delivering exceptional quality extends to every aspect of our process. We proudly collaborate with a leading professional British printing company, who crafts exhibition-quality FineArt 12 giclées posters on EMA paper 200gsm.
To ensure a consistent and identical standard of excellence, our printing partner operates state-of-the-art facilities in the UK, Europe, the US, and Australia. This strategic approach allows us to produce our posters in close proximity to their destination, minimizing delivery times and environmental impact.
Rest assured, regardless of where your order is placed, our posters maintain the same high-quality craftsmanship and are printed using the finest materials. Our partnership ensures that you receive an exquisite piece of art, meticulously crafted for lasting beauty.
When will I receive my Retro Poster(s)?
All delivery timings are estimates and Myretroposter declines any responsibility for delays due to courier services, customs, or local distribution networks.
Please read our Shop Policies before placing your order.
Where do you ship from? Should I expect Customs Duty?
For customers in the UK, Europe, the US, Canada and Australia, our printing partner has facilities in Alton and Harrogate for the UK, Venlo in the Netherlands for all EU orders, Charlotte (NC) for US orders, Alberta or Vancouver for Canada and Victoria for Australia, to minimize the likelihood of customs duties. However, it's important to note that for orders outside these specified regions, customs duties, taxes, and fees may be imposed by the destination country.
Please be aware that any such charges are beyond our control and are the responsibility of the recipient. We recommend consulting your local customs office to understand the potential fees that may apply to your order.
At Myretroposter.com, we're committed to transparency and ensuring your satisfaction. While we do our best to prevent customs duties, your understanding of any applicable charges is appreciated.
My order seems lost. What should I do?
If you suspect your parcel might be lost, please follow these steps to help us address the issue swiftly:
- Immediate Notification: Do not wait for 30 days to alert us if your order hasn't arrived within the expected delivery timeframe. It's crucial to inform us as soon as you suspect a delay or loss so that we can take prompt action.
- Lost Parcel Policy: A parcel is considered lost if it has not been delivered 30 days after dispatch. However, this 30-day period represents the maximum time before we officially classify a package as lost. We strongly encourage you to contact us well before this deadline if you believe your parcel is delayed.
- Investigation Process: Upon receiving your notification, we will initiate an investigation with the shipping carrier to locate your parcel. We appreciate your patience during this search period.
- Replacement Process: If the investigation confirms that your parcel is lost, we will replace your order at no additional cost to you. Express Shipping of Replacements: To reduce your waiting time, replacement prints will be shipped express, ensuring their rapid delivery.
- Timely Communication: Effective communication is key to efficiently resolving any delivery issues. We will keep you updated throughout the process and may reach out for further information if needed.
Our aim is to ensure a pleasant and hassle-free shopping experience. If you have any more questions or require assistance, please do not hesitate to contact our customer service team. We're here to help!
A poster has been delivered damaged. How can I get it replaced?
At Myretroposter, we strive to ensure your order reaches you in perfect condition. In the unfortunate event that your posters are damaged during transit or have defects that were not spotted at quality-check stage, we've got you covered with our replacement policy:
Damaged Prints:
If you receive damaged posters, please follow these steps:
- Notification: Notify us within 7 days of receiving the damaged posters. Send clear photos of the damaged items and the packaging to our customer service team.
- Replacement Process: Upon verification, we will initiate the replacement process. You won't incur any additional costs for the replacement of damaged prints.
- Return of Damaged Prints: You may be asked to return the damaged posters. If required, we'll cover the return shipping costs.
How can I return my poster?
Yes, at Myretroposter, we recognize that it's sometimes hard to visualize how a large image, such as a poster, will look in real life from a picture seen on a website. If you're not completely satisfied with your purchase for any reason, we offer a return policy to accommodate your needs. Here are the key points of our return policy:
- Return Window: You have 15 days from the date of reception to initiate a return for a refund.
- Condition of Items: To be eligible for a refund, the returned posters must be in their original condition and packaging. This ensures that they haven't been damaged or altered in any way.
- Return Shipping: Customers are responsible for the return shipping fees. We recommend that you securely package the posters to prevent any damage during transit, as this could affect your eligibility for a refund.
- Refund Processing: Upon receipt of the returned posters and confirmation of their condition, we will process your refund. Our aim is to complete this process promptly to minimize any inconvenience.
- Deductions: Please be aware that any customs duty or fees incurred for the return will be deducted from your refund amount. This is important to consider, especially for international returns.
- Return Address: Returns should exclusively be sent to our stock in Europe. This is our dedicated location for handling returns as our printing partner doesn't accept returns.
For a smooth return process or if you have any questions, please don't hesitate to contact our customer service team. Your satisfaction is paramount to us, and we're here to assist you with any aspect of your purchase.
How can I exchange a poster I bought from Myretroposter?
At Myretroposter, your satisfaction is our priority, and we understand that sometimes you might want to exchange a poster you've purchased. If you're looking to exchange a poster within 15 days of receiving your order (this does not apply to replacements for lost or damaged prints), here are the steps and policies you should be aware of:
- Return Window: You have 15 days from the date you received your order to initiate an exchange.
- Return Shipping: You will be responsible for the return shipping fees. It's important to package the posters securely to prevent damage during transit, as damaged returns may not be eligible for exchange.
- Price Difference: If the new poster you're selecting has a different price than the original, you will need to cover any additional costs. Conversely, if the new poster is less expensive, we will refund the difference.
- Shipping Fee for the Exchanged Poster: There will be a shipping fee applied for sending out the exchanged poster to you. This fee covers the cost of shipping and handling for the new item.
- Return Address: All returns for exchange should be sent to our address in Europe. This is our dedicated facility for processing returns and exchanges efficiently.
- Customs Duty: Please note that Myretroposter is not responsible for any customs duty that may be incurred. Any applicable customs duty will be charged accordingly.
After we receive your returned poster and verify its condition, we will process your exchange promptly. If you have any questions or need assistance with the exchange process, please don't hesitate to contact our customer service team. We're here to help ensure your experience with Myretroposter is as enjoyable and satisfying as possible.
Framing, resizing and other options
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Neurolens are the first and only prescription lenses that include an element of contoured prism in their design. This prism is designed to bring the patient's eyes into more equal alignment, and this should help to provide relief from the symptoms that are associated with several eye misalignment conditions, including digital eye strain and binocular vision dysfunction.
Digital eye strain is the name given to describe a group of symptoms that can occur when someone spends long periods of time using digital devices. Since using digital devices requires the eyes to work harder than normal and we don't always position our devices the perfect distance away, it can lead to issues such as eye pain, dry and irritated eyes, eye fatigue, light sensitivity and blurred vision. Unsurprisingly, the number of people who are experiencing digital eye strain has grown significantly over the last few years and is expected to continue to do so.
Binocular vision dysfunction, also known as BVD for short, is another eye condition but is one that is very misunderstood. Binocular vision dysfunction occurs when the eyes aren't perfectly aligned, causing your brain and eyes to work harder than normal in order to create a clear visual image and remain focused. This places pressure on the trigeminal nerve, which is the nerve that is responsible for the majority of the sensations that we experience in our head and back. BVD can often manifest as other things owing to the huge range of symptoms that are associated with the condition. These can include, but aren't limited to:
Blurred vision
Double vision
Motion sickness
Many people don't think to visit an eye doctor when they are experiencing these symptoms, but all can occur simply because the eyes are out of alignment.
As well as containing your usual prescription, Neurolens lenses also contain a specific amount of contoured micro-prism. This micro-prism alters the position of images so that they are aligned in the same plane. This then reduces the pressure on the muscles around the eyes as well as bringing the eyes into alignment, easing the symptoms that the patient has been experiencing.
The amount of prism in Neurolens lenses is decided using the Neurolens eye-tracking device. This non-invasively measures the misalignment that the patient is experiencing, and this is used to form the basis for the patient's Neurolens prescription. After this, it's fairly normal for the amount of prism to need to be adjusted by infinitesimal amounts to achieve the optimal relief from your symptoms. Most patients who choose Neurolens treatment see a 50% improvement in their vision as soon as they start to have micro-prism incorporated into their prescription lenses. However, with careful adjustments, many patients see as much as an 80% reduction in the effects of digital eye strain and binocular vision dysfunction.
Want more information about Neurolens? Please contact our knowledgeable eye care specialists.


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The FA National Referee Strategy (NRS) sets out the organisational blueprint of the key principles, frameworks and structures for referee recruitment, retention and development.
The NRS demonstrates The FA's commitment to maximising the opportunities for inclusion, participation and development at all levels of the refereeing pyramid across a range of roles in refereeing.
Refereeing at all levels will benefit from a NRS consisting of eight strands:
- The DNA of English refereeing
- The Structure of English refereeing
- National Referee Curriculum (NRC)
- Recruitment and Retention
- Participation and Coverage
- Development Pathways and Opportunities
- Governance and Administration
- Raising the profile of English refereeing
The DNA of English Refereeing
The DNA of English refereeing consists of seven core values which underpin all aspects of English refereeing and are all required for success to be achieved, on and off the field: