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Bonnie Brae
Bonnie Brae is located east of University Avenue between Mississippi and Exposition avenues, Steele Street and University Boulevard. The community was developed in the 1920's on land that had been granted to the Kansas Pacific Railroad in 1870. The railroad was eventually sold to farmers and it later became part of the town of South Denver.
Bonnie Brae means "pleasant hill" in Gaelic. George Olinger, an active Denver businessman began accumulating property in the area and strived to recreate the aura of a peaceful Scottish village in Denver.
Many of the homes in Bonnie Brae were constructed during the 1920's and 1930's utilizing innovative architectural compositions. Home styles in Bonnie Brae range from charming Cape Cods and tidy brick ranches to two-story Brick and Frame homes, English Tudors and some of the best examples of International Style and Art Moderne Architecture.
Winding streets surrounding an elliptical-shaped park make Bonnie Brae a serene residential oasis in the midst of the city. As Bonnie Brae grew, many businesses opened along University Boulevard. Today the thriving commercial area between Exposition and Ohio streets still functions as the "Main Street" of one Denver's most charming neighborhoods.
The community's quaint commercial district is within walking distance of most homes where residents can enjoy a wide variety of restaurants ranging from fine dining and coffee shops, to ice cream parlors and sports bars. Dolly Madison Dairy opened in the 1940's, now the Bonnie Brae Ice Cream and the Bellaire Restaurant, now the Campus Lounge, in 1961...and both remain in business today.
Bonnie Brae has had an organized neighborhood association for many years. There is an annual picnic in late summer where neighbors can reconnect and enjoy a variety of food and activities. The association's mission is to provide a conduit with the city, assist in community development, and facilitate any efforts to improve the quality of life in Bonnie Brae
Bonnie Brae Cherry Creek Congress Park Country Club Highlands Park Hill Washington Park


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subset: commoncrawl


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Architectural Exit Signs
Exit Signs
The exit signs category features lighted LED exit signs to comply with building fire codes and insurance standards. These energy-saving, illuminated, long-life LED exit signs use less than 5 watts of power, lowering your energy consumption and saving you money every month. We offer a wide range of designs and features for lighted LED exit signs including: Edge-Lit Exit Sign, Cast Aluminum Exit Sign, Steel Exit Signs, Wet Location Exit Signs and Self Testing Exit Signs.


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"Givers Gain"....... Subscribe to: | Members Only |
Email William HincksFill in the From, Subject, and Your Message boxes below to send an email to this person.You will receive a copy of the email. Copyright © 1998-2005. All rights reserved. Click here to make suggestions or request help with this site |


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Oregon Caves Quilt Block Design by Susan Davis - 68
Regular price
Oregon Caves Quilt Block Design by Susan Davis - © 2016-2019.
NOTE: This is not a pattern. You are purchasing a digital image file to download and print on your printer. You may print on cloth to create your own quilt blocks. Please let us know if you have any questions.
We are listing 90 National Park Service quilt block designs by Susan Davis. Susan is a successful designer and an accomplished quilter. She worked more than two years to develop these NPS designs. Susan's NPS designs are based on traditional star patterns in the quilting hobby. Susan created these unique NPS quilt block designs to commemorate the Centennial of the National Park Service in 2016. These are the first and only quilt block designs created exclusively for America's National Parks and Monuments.
These NPS quilt block designs can be printed on cloth as quilt blocks and on paper as greeting cards, for scrap booking and home decor prints. Each block has the name of the NPS location and a matching border. The colors used in each design are indigenous to that location.
We are also listing 50 State quilt block designs by Susan Davis. The collage below shows all 50 state quilt block designs. These are the same format as the NPS designs and can be downloaded to print on your personal printer.
You are purchasing a digital image file that has been professionally adjusted for high quality reproduction. Downloaded images will not have any watermarks. These image files are all 720x1080 pixels (2:3 ratio). You will need to size your images for your personal use. We have links to sites that can assist you in sizing images. See INFO - F.A.Q.
Standard print sizes in 2:3 ratio are 4x6, 6x9, and 8x12 inches. There may be a loss of image quality if the image is reproduced larger than 8x12 inches. If you need a higher resolution file contact us for details.
Quilt Blocks, Greeting Cards and Prints are popular formats for our images. If you want to print quilt blocks we have patterns for wall hangings, tote bags, table runners and hot pads on our National Park Quilts pattern page. We also have links to companies that produce fabric sheets for printing quilt blocks. See INFO - F.A.Q.
NOTE: You are authorized to use this image file for your personal use only. All of the designs on this website are ©2019 Susan Davis - All Rights Reserved. See Terms and Conditions. If you have questions pertaining to copyright issues regarding these designs please contact us.


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MACloth Straps V neck Dark Navy Prom Dress Ball Gown Tulle Wedding Party Formal Gown
Product Details
MACloth Straps V neck Dark Navy Prom Dress Ball Gown Tulle Wedding Party Formal Gown
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Bodice Color: ---
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- Size
Please see the Size Chart first when choosing the size. We provide custom size service. If the standard size does not match your actual measurements, you can follow the guide on How to Measure and provide us your measurements. We will make the dress as per your measurements. The following are the general measurements to make the dress.
- A. Full Bust:__________;(Essential. The fullest part of bust!)
- B. Waist:__________;(Essential)
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- X. Hollow to waist: __________;
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Standard shipping service: You will receive the dress within 4-6 weeks. It includes 2-3weeks of tailoring, and 2-3 weeks of shipment.
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If you need to receive the dress earlier than schedule or have question on time of specific dress style, please feel free to contact us.
- Return and Refund
The dress can be returned within 14 days after the dress is delivered. Any product that has been used does not qualify for a return. Returned items must be unused, with original tags and packaging. The detailed return policy might be slightly different between countries due to local regulation and logistics. For details on the return policy , please contact us.


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Many times what happens far away ends up coded in numbers and officialdom.
Like this weekend, a blast near NATO headquarters in Afghanistan killed at least six. NPR's Dana Farrington noted that a suicide bomber blew himself up near the entrance of Camp Eggers, where many children who work on the streets set up to sell trinkets.
Today, we get the heartbreaking news that six of the dead were children and four of them were part of the Skateistan program.
Back in 2010, we told you about the Kabul's first skatepark. We pointed you to a short documentary that juxtaposed, "the simplicity and the innocence of skateboarding with the rugged, war-torn landscape of Kabul."
In a press release, today, Skateistan released the names of the dead.
Khorshid, they say, was 14 and a skate instructor.
"From the start, Khorshid (whose name translates to 'happy' in English) stood apart with a tough, cheeky and sensitive personality, smiling no matter what troubles she had to deal with day-to-day," the program reports. "She knew what she wanted in life and wasn't afraid to fight for it despite having more responsibilities and sorrows than a child should ever have."
Nawab, 17, also died. He was one of the first boys in the program and was known as having one of best kickflips.
Parwana was Khorshid's younger sister. She was just 8-years-old.
Assad, the program says, was not a skater but he was family and well known at the skatepark.
As USA Today reports, The skatepark was founded in 2007.
Copyright 2021 NPR. To see more, visit https://www.npr.org.


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P0AA3 – Hybrid Battery Negative Contactor Circuit
Code | Fault Location | Probable Cause |
P0AA3 | Hybrid Battery Negative Contactor Circuit (Buy Part On Amazon) | - |
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American Anthem: 2009 by Holt
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The domain within your query sequence starts at position 1220 and ends at position 1260; the E-value for the WD40 domain shown below is 3e-16.
The domain was found using the schnipsel database
WD40WD40 repeats |
SMART accession number: | SM00320 |
Description: | Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain. |
Interpro abstract (IPR001680): | WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein or protein-DNA interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins [ (PUBMED:30069656) ]. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase [ (PUBMED:11814058) (PUBMED:10322433) ]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events. |
GO function: | protein binding (GO:0005515) |
Family alignment: |
There are 1918936 WD40 domains in 345139 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing WD40 domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with WD40 domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing WD40 domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
Cellular role: signalling
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Garcia-Higuera I et al.
- Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.
- Biochemistry. 1996; 35: 13985-94
- Display abstract
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular proteins, and they should be resistant to cleavage by trypsin. However, the only studied example of a WD-repeat protein, G beta, synthesized in vitro in a rabbit reticulocyte lysate, is unable to fold into a native structure without its partner protein G gamma. The non-WD-repeat amino terminal alpha helix of G beta does not inhibit folding because G beta does not fold even when this region is removed. It is not known whether all WD-repeat proteins are unable to fold when synthesized in an in vitro system. We synthesized seven members of the family in a rabbit reticulocyte lysate, determined their Stokes radius, sedimentation coefficient, and frictional ratio, and assayed their stability to trypsin. Our working definition of folding was that the proteins from globular, trypsin-resistant structures because, except for G beta gamma, their functions are not known or cannot be assayed in reticulocyte lysates. We chose proteins that include amino and carboxyl extensions as well as proteins that are made up entirely of WD-repeats. We show that unlike G beta, several proteins with WD-repeats are able to fold into globular proteins in a rabbit reticulocyte lysate. One protein, beta Trcp, formed large aggregates like G beta, suggesting that it may also require a partner protein. Despite the presence of many potential tryptic cleavage sites, all of the proteins that did fold gave stable large products on tryptic proteolysis, as predicted on the basis of the structure of G beta. These studies suggest that other WD-repeat proteins are likely to form propeller structures similar to G beta.
- Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB
- Crystal structure of a G-protein beta gamma dimer at 2.1A resolution.
- Nature. 1996; 379: 369-74
- Display abstract
Many signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals into intracellular responses. Upon nucleotide exchange catalysed by activated receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta gamma dimers, either of which can modulate many downstream effectors. Here we use multiwavelength anomalous diffraction data to solve the crystal structure of the beta gamma dimer of the G protein transducin. The beta-subunit is primarily a seven-bladed beta-propeller that is partially encircled by an extended gamma-subunit. The beta-propeller, which contains seven structurally similar WD repeats, defines the stereochemistry of the WD repeat and the probable architecture of all WD-repeat-containing domains. The structure details interactions between G protein beta- and gamma-subunits and highlights regions implicated in effector modulation for the conserved family of G protein beta gamma dimers.
- Dynlacht BD, Weinzierl RO, Admon A, Tjian R
- The dTAFII80 subunit of Drosophila TFIID contains beta-transducin repeats.
- Nature. 1993; 363: 176-9
- Display abstract
A key component of the RNA polymerase II transcriptional apparatus, TFIID, is a multi-protein complex containing the TATA box-binding protein (TBP) and at least seven tightly associated factors (TAFs). Although the functions of most TFIID subunits are unknown, it is clear that TAFs are not necessary for basal activity but that one or more are required for regulated transcription, and so behave as coactivators. The presence of multiple subunits indicates that there is an intricate assembly process and that TAFs may be responsible for other activities. We have described the properties of the subunit dTAFII110, which can interact directly with the transcriptional activator Sp1 (ref. 5). In addition, the largest subunit, dTAFII250, binds directly to TBP and links other TAFs to the complex. Here we describe the cloning, expression and partial characterization of the Drosophila TAF of M(r) 80,000, dTAFII80. Sequence analysis reveals that dTAFII80 contains several copies of the WD40 (beta-transducin) repeat. Moreover, dTAFII80 shares extended sequence similarity with an Arabidopsis gene, COP1, which encodes a putative transcription factor that is though to regulate development. We have expressed recombinant dTAFII80 and begun to characterize its interaction with other members of the TFIID complex. Purified recombinant dTAFII80 is unable to bind TBP directly or to interact strongly with the C-terminal domain of dTAFII250 (delta N250). Instead, dTAFII80 is only able to recognize and interact with a higher-order complex containing TBP, delta N250, 110 and 60. These findings suggest the formation of TFIID may require an ordered assembly of the TAFs, some of which bind directly to TBP and others that are tethered to the complex as a result of specific TAF/TAF interactions.
- Fong HK et al.
- Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.
- Proc Natl Acad Sci U S A. 1986; 83: 2162-6
- Display abstract
Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase in photoreceptor cells, is comprised of three subunits. We have identified and analyzed cDNA clones of the bovine transducin beta subunit that may be highly conserved or identical to that in other G proteins. From the cDNA nucleotide sequence of the entire coding region, the primary structure of a 340-amino acid protein was deduced. The encoded beta subunit has a Mr of 37,375 and is comprised of repetitive homologous segments arranged in tandem. Furthermore, significant homology in primary structure and segmental sequence exists between the beta subunit and the yeast CDC4 gene product. The Mr 37,375 beta subunit polypeptide is encoded by a 2.9-kilobase (kb) mRNA. However, there exists in retina other beta-related mRNAs that are divergent from the 2.9-kb mRNA on the basis of oligonucleotide and primer-extended probe hybridizations. All mammalian tissues and clonal cell lines that have been examined contain at least two beta-related mRNAs, usually 1.8 and 2.9 kb in length. These results suggest that the mRNAs are the processed products of a small number of closely related genes or of a single highly complex beta gene.
- Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the WD40 domain.
Protein Disease Peroxisomal targeting signal 2 receptor (O00628) (SMART) OMIM:601757: Rhizomelic chondrodysplasia punctata, type 1
OMIM:215100:Platelet-activating factor acetylhydrolase IB subunit alpha (P43034) (SMART) OMIM:601545: Lissencephaly-1 ; Subcortical laminar heterotopia
OMIM:247200: Miller-Dieker lissencephaly syndromeDNA damage-binding protein 2 (Q92466) (SMART) OMIM:600811: Xeroderma pigmentosum, group E, DDB-negative subtype
OMIM:278740: - Metabolism (metabolic pathways involving proteins which contain this domain)
Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 15.71 map04120 Ubiquitin mediated proteolysis 10.79 map04111 Cell cycle - yeast 9.05 map04310 Wnt signaling pathway 7.06 map04110 Cell cycle 6.13 map04530 Tight junction 4.93 map04810 Regulation of actin cytoskeleton 4.53 map04150 mTOR signaling pathway 3.99 map03022 Basal transcription factors 3.99 map04350 TGF-beta signaling pathway 3.99 map04730 Long-term depression 3.60 map04115 p53 signaling pathway 2.66 map04340 Hedgehog signaling pathway 2.53 map04140 Regulation of autophagy 2.40 map04080 Neuroactive ligand-receptor interaction 2.13 map04914 Progesterone-mediated oocyte maturation 2.00 map04910 Insulin signaling pathway 1.60 map00565 Ether lipid metabolism 1.46 map04742 Taste transduction 1.46 map04210 Apoptosis 1.33 map05222 Small cell lung cancer 1.33 map00632 Benzoate degradation via CoA ligation 0.93 map00562 Inositol phosphate metabolism 0.40 map00350 Tyrosine metabolism 0.40 map00340 Histidine metabolism 0.40 map00642 Ethylbenzene degradation 0.40 map00564 Glycerophospholipid metabolism 0.40 map00960 Alkaloid biosynthesis II 0.40 map00903 Limonene and pinene degradation 0.40 map00310 Lysine degradation 0.40 map00360 Phenylalanine metabolism 0.40 map00624 1- and 2-Methylnaphthalene degradation 0.40 map00380 Tryptophan metabolism 0.27 map00910 Nitrogen metabolism 0.27 map05210 Colorectal cancer 0.13 map04370 VEGF signaling pathway 0.13 map04662 B cell receptor signaling pathway 0.13 map04020 Calcium signaling pathway 0.13 map04720 Long-term potentiation 0.13 map03060 Protein export 0.13 map04360 Axon guidance 0.13 map04010 MAPK signaling pathway 0.13 map00100 Biosynthesis of steroids 0.13 map00561 Glycerolipid metabolism 0.13 map02010 ABC transporters - General 0.13 map04660 T cell receptor signaling pathway 0.13 map00230 Purine metabolism 0.13 map04330 Notch signaling pathway 0.13 map04650 Natural killer cell mediated cytotoxicity This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with WD40 domain which could be assigned to a KEGG orthologous group, and not all proteins containing WD40 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of WD40 domains in PDB
PDB code Main view Title 1a0r HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA 1b9x STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN 1b9y STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA 1erj CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1 1gg2 G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND 1got HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS 1gp2 G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND 1gxr WD40 Region of Human Groucho/TLE1 1k8k Crystal Structure of Arp2/3 Complex 1nex Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex 1nr0 Two Seven-Bladed Beta-Propeller Domains Revealed By The Structure Of A C. elegans Homologue Of Yeast Actin Interacting Protein 1 (AIP1). 1omw Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits 1p22 Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase 1pev Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans 1pgu YEAST ACTIN INTERACTING PROTEIN 1 (AIP1), Se-Met PROTEIN, MONOCLINIC CRYSTAL FORM 1pi6 YEAST ACTIN INTERACTING PROTEIN 1 (Aip1), ORTHORHOMBIC CRYSTAL FORM 1r5m Crystal Structure Of The C-Terminal WD40 Domain Of Sif2 1s4u Crystal Structure analysis of the beta-propeller protein Ski8p 1sq9 Structure of Ski8p, a WD repeat protein involved in mRNA degradation and meiotic recombination 1tbg BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN 1trj Homology Model of Yeast RACK1 Protein fitted into 11.7A cryo-EM map of Yeast 80S Ribosome 1tyq Crystal structure of Arp2/3 complex with bound ATP and calcium 1u2v Crystal structure of Arp2/3 complex with bound ADP and calcium 1u4c Structure of spindle checkpoint protein Bub3 1vyh PAF-AH Holoenzyme: Lis1/Alfa2 1xhm The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer 1yfq High resolution S. cerevisiae Bub3 mitotic checkpoint protein 2aq5 Crystal Structure of Murine Coronin-1 2b4e Crystal Structure of Murine Coronin-1: monoclinic form 2bcj Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits 2ce8 An EH1 peptide bound to the Groucho-TLE WD40 domain. 2ce9 A WRPW peptide bound to the Groucho-TLE WD40 domain. 2cnx WDR5 and Histone H3 Lysine 4 dimethyl complex at 2.1 angstrom 2co0 WDR5 and unmodified Histone H3 complex at 2.25 angstrom 2g99 Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 2g9a Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5 2gnq Structure of wdr5 2h13 Crystal structure of WDR5/histone H3 complex 2h14 Crystal of WDR5 (apo-form) 2h68 Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 2h6k Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 2h6n Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 2h6q Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex 2h9l WDR5delta23 2h9m WDR5 in complex with unmodified H3K4 peptide 2h9n WDR5 in complex with monomethylated H3K4 peptide 2h9p WDR5 in complex with trimethylated H3K4 peptide 2hes Cytosolic Iron-sulphur Assembly Protein- 1 2i3s Bub3 complex with Bub1 GLEBS motif 2i3t Bub3 complex with Mad3 (BubR1) GLEBS motif 2o9k WDR5 in Complex with Dimethylated H3K4 Peptide 2oit Crystal Structure of the N-terminal Domain of the Human Proto-oncogene Nup214/CAN 2ovp Structure of the Skp1-Fbw7 complex 2ovq Structure of the Skp1-Fbw7-CyclinEdegC complex 2ovr Structure of the Skp1-Fbw7-CyclinEdegN complex 2p9i Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde 2p9k Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde 2p9l Crystal Structure of bovine Arp2/3 complex 2p9n Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 2p9p Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP 2p9s Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+ 2p9u Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium 2pbi The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure 2pm6 Crystal Structure of yeast Sec13/31 edge element of the COPII vesicular coat, native version 2pm7 Crystal structure of yeast Sec13/31 edge element of the COPII vesicular coat, selenomethionine version 2pm9 Crystal structure of yeast Sec13/31 vertex element of the COPII vesicular coat 2qxv Structural basis of EZH2 recognition by EED 2trc PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX 2vdu Structure of trm8, m7G methylation enzyme 2xl2 WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE 2xl3 WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE 2xu7 Structural basis for RbAp48 binding to FOG-1 2xyi Crystal Structure of Nurf55 in complex with a H4 peptide 2yb8 Crystal structure of Nurf55 in complex with Su(z)12 2yba Crystal structure of Nurf55 in complex with histone H3 2ymu Structure of a highly repetitive propeller structure 2ynn yeast betaprime COP 1-304 with KTKTN motif 2yno yeast betaprime COP 1-304H6 2ynp yeast betaprime COP 1-604 with KTKTN motif 3acp Crystal Structure of Yeast Rpn14, a Chaperone of the 19S Regulatory Particle of the Proteasome 3ah8 Structure of heterotrimeric G protein Galpha-q beta gamma in complex with an inhibitor YM-254890 3bg0 Architecture of a Coat for the Nuclear Pore Membrane 3bg1 Architecture of a Coat for the Nuclear Pore Membrane 3c99 Structural Basis of Histone H4 Recognition by p55 3c9c Structural Basis of Histone H4 Recognition by p55 3cfs Structural basis of the interaction of RbAp46/RbAp48 with histone H4 3cfv Structural basis of the interaction of RbAp46/RbAp48 with histone H4 3cik Human GRK2 in Complex with Gbetagamma subunits 3dm0 Maltose Binding Protein fusion with RACK1 from A. thaliana 3dw8 Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit 3dwl Crystal Structure of Fission Yeast Arp2/3 Complex Lacking the Arp2 Subunit 3dxk Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636 3dxm Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 3eg6 Structure of WDR5 bound to MLL1 peptide 3ei1 Structure of hsDDB1-drDDB2 bound to a 14 bp 6-4 photoproduct containing DNA-duplex 3ei2 Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex 3ei3 Structure of the hsDDB1-drDDB2 complex 3ei4 Structure of the hsDDB1-hsDDB2 complex 3emh Structural basis of WDR5-MLL interaction 3ewe Crystal Structure of the Nup85/Seh1 Complex 3f3f Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21 3f3g Crystal structure of the nucleoporin pair Nup85-Seh1, space group P212121 3f3p Crystal structure of the nucleoporin pair Nup85-Seh1, space group P21212 3fhc Crystal structure of human Dbp5 in complex with Nup214 3fm0 Crystal structure of WD40 protein Ciao1 3fmo Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 3fmp Crystal structure of the nucleoporin Nup214 in complex with the DEAD-box helicase Ddx19 3frx Crystal Structure of the Yeast Orthologue of RACK1, Asc1. 3gfc Crystal Structure of Histone-binding protein RBBP4 3gre Crystal structure of Saccharomyces cerevisiae Vps15 WD repeat domain 3i2n Crystal Structure of WD40 repeats protein WDR92 3iiw Crystal structure of Eed in complex with a trimethylated histone H3K27 peptide 3iiy Crystal structure of Eed in complex with a trimethylated histone H1K26 peptide 3ij0 Crystal structure of Eed in complex with a trimethylated histone H3K9 peptide 3ij1 Crystal structure of Eed in complex with a trimethylated histone H4K20 peptide 3ijc Crystal structure of Eed in complex with NDSB-195 3iko Crystal structure of the heterotrimeric Sec13-Nup145C-Nup84 nucleoporin complex 3j2t An improved model of the human apoptosome 3j6x 3J6X 3j6y 3J6Y 3j77 3J77 3j78 3J78 3j7p 3J7P 3j7r 3J7R 3j80 3J80 3j81 3J81 3jag 3JAG 3jah 3JAH 3jai 3JAI 3jaj 3JAJ 3jam 3JAM 3jan 3JAN 3jap 3JAP 3jaq 3JAQ 3jb9 3JB9 3jbt 3JBT 3jcm 3JCM 3jcr 3JCR 3jct 3JCT 3jpx EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex 3jro NUP84-NUP145C-SEC13 edge element of the NPC lattice 3jrp SEC13 with NUP145C (AA109-179) insertion blade 3jzg Structure of EED in complex with H3K27me3 3jzh EED-H3K79me3 3jzn Structure of EED in apo form 3k26 Complex structure of EED and trimethylated H3K4 3k27 Complex structure of EED and trimethylated H3K9 3krw Human GRK2 in complex with Gbetgamma subunits and balanol (soak) 3krx Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal) 3mkq Crystal structure of yeast alpha/betaprime-COP subcomplex of the COPI vesicular coat 3mks Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 3mmy Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 3mxx Crystal structure of WDR5 mutant (S62A) 3mzk Sec13/Sec16 complex, S.cerevisiae 3mzl Sec13/Sec31 edge element, loop deletion mutant 3n0d Crystal structure of WDR5 mutant (W330F) 3n0e Crystal structure of WDR5 mutant (W330Y) 3odt Crystal structure of WD40 beta propeller domain of Doa1 3ow8 Crystal Structure of the WD repeat-containing protein 61 3p4f Structural and biochemical insights into MLL1 core complex assembly and regulation. 3psc Bovine GRK2 in complex with Gbetagamma subunits 3psl Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3 based peptide mimetic 3pvu Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101) 3pvw Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A) 3rfg Crystal structure of the yeast RACK1 dimer in space group P63 3rfh Crystal structure of the yeast RACK1 dimer in space group P21 3rse Structural and biochemical characterization of two binding sites for nucleation promoting factor WASp-VCA on Arp2/3 complex 3sfz Crystal structure of full-length murine Apaf-1 3shf Crystal structure of the R265S mutant of full-length murine Apaf-1 3smr Crystal structure of human WD repeat domain 5 with compound 3sn6 Crystal structure of the beta2 adrenergic receptor-Gs protein complex 3ukr Crystal structure of Bos taurus Arp2/3 complex with bound inhibitor CK-666 3uku Structure of Arp2/3 complex with bound inhibitor CK-869 3ule Structure of Bos taurus Arp2/3 complex with bound inhibitor CK-869 and ATP 3ur4 Crystal structure of human WD repeat domain 5 with compound 3uvk Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 3uvl Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 3uvm Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 3uvn Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A 3uvo Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B 3uzs Structure of the C13.28 RNA Aptamer Bound to the G Protein-Coupled Receptor Kinase 2-Heterotrimeric G Protein Beta 1 and Gamma 2 Subunit Complex 3v5w Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine 3v7d Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex 3vl1 Crystal structure of yeast Rpn14 3vu4 Crystal structure of Kluyvelomyces marxianus Hsv2 3w15 Structure of peroxisomal targeting signal 2 (PTS2) of Saccharomyces cerevisiae 3-ketoacyl-CoA thiolase in complex with Pex7p and Pex21p 3zwl Structure of eukaryotic translation initiation factor eIF3i complex with eIF3b C-terminus (655-700) 4a08 Structure of hsDDB1-drDDB2 bound to a 13 bp CPD-duplex (purine at D-1 position) at 3.0 A resolution (CPD 1) 4a09 Structure of hsDDB1-drDDB2 bound to a 15 bp CPD-duplex (purine at D-1 position) at 3.1 A resolution (CPD 2) 4a0a Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.6 A resolution (CPD 3) 4a0b Structure of hsDDB1-drDDB2 bound to a 16 bp CPD-duplex (pyrimidine at D-1 position) at 3.8 A resolution (CPD 4) 4a0k STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX 4a0l Structure of DDB1-DDB2-CUL4B-RBX1 bound to a 12 bp abasic site containing DNA-duplex 4a11 Structure of the hsDDB1-hsCSA complex 4a7j Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance 4aez Crystal Structure of Mitotic Checkpoint Complex 4aow Crystal structure of the human Rack1 protein at a resolution of 2.45 angstrom 4av8 Kluyveromyces lactis Hsv2 complete loop 6CD 4av9 Kluyveromyces lactis Hsv2 4bh6 Insights into degron recognition by APC coactivators from the structure of an Acm1-Cdh1 complex 4bl0 Crystal structure of yeast Bub3-Bub1 bound to phospho-Spc105 4bts 4BTS 4buj Crystal structure of the S. cerevisiae Ski2-3-8 complex 4bzj The structure of the COPII coat assembled on membranes 4bzk The structure of the COPII coat assembled on membranes 4ci8 Crystal structure of the tandem atypical beta-propeller domain of EML1 4cy1 Crystal structure of the KANSL1-WDR5 complex. 4cy2 Crystal structure of the KANSL1-WDR5-KANSL2 complex. 4cy3 Crystal structure of the NSL1-WDS complex. 4cy5 Crystal structure of the NSL1-WDS-NSL2 complex. 4czv 4CZV 4czx 4CZX 4czy 4CZY 4d0k 4D0K 4d5l 4D5L 4d61 4D61 4d6v 4D6V 4e54 Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair 4e5z Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair 4erq X-ray structure of WDR5-MLL2 Win motif peptide binary complex 4ery X-ray structure of WDR5-MLL3 Win motif peptide binary complex 4erz X-ray structure of WDR5-MLL4 Win motif peptide binary complex 4es0 X-ray structure of WDR5-SETd1b Win motif peptide binary complex 4esg X-ray structure of WDR5-MLL1 Win motif peptide binary complex 4ewr X-ray structure of WDR5-SETd1a Win motif peptide binary complex 4exv Structure of Kluyveromyces lactis Hsv2p 4fhl Nucleoporin Nup37 from Schizosaccharomyces pombe 4fhm Nup37-Nup120(aa1-961) complex from Schizosaccharomyces pombe 4fhn Nup37-Nup120 full-length complex from Schizosaccharomyces pombe 4g56 Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis 4gga Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C 4ggc Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C 4ggd Structural analysis of human Cdc20 supports multisite degron recognition by APC/C. 4gm3 Crystal structure of human WD repeat domain 5 with compound MM-101 4gm8 Crystal structure of human WD repeat domain 5 with compound MM-102 4gm9 Crystal structure of human WD repeat domain 5 with compound MM-401 4gmb Crystal structure of human WD repeat domain 5 with compound MM-402 4gq1 Nup37 of S. pombe 4gq2 S. pombe Nup120-Nup37 complex 4gqb Crystal Structure of the human PRMT5:MEP50 Complex 4h5i Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P1 form) 4h5j Crystal Structure of the Guanine Nucleotide Exchange Factor Sec12 (P64 form) 4i79 Crystal structure of human NUP43 4ia9 Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide 4j0w Structure of U3-55K 4j0x Structure of Rrp9 4j73 Crystal structure of beta'-COP/p25 complex 4j77 Crystal structure of beta'-COP/hWbp1 complex 4j78 Crystal structure of beta'-COP/Emp47p complex 4j79 Crystal structure of beta'-COP/PEDVspike complex 4j81 Crystal structure of beta'-COP/Insig-1 complex 4j82 Crystal structure of beta'-COP/Insig-2 complex 4j84 Crystal structure of beta'-COP/Scyl1 complex 4j86 Crystal structure of beta'-COP/yWbp1 complex 4j87 Crystal structure of alpha-COP 4j8b Crystal structure of alpha-COP/Emp47p complex 4j8g Crystal structure of alpha-COP/E19 complex 4jd2 Crystal structure of Bos taurus Arp2/3 complex binding with Mus musculus GMF 4jsn structure of mTORdeltaN-mLST8 complex 4jsp structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex 4jsv mTOR kinase structure, mechanism and regulation. 4jsx structure of mTORDeltaN-mLST8-Torin2 complex 4jt5 mTORdeltaN-mLST8-pp242 complex 4jt6 structure of mTORDeltaN-mLST8-PI-103 complex 4jxm Crystal structure of RRP9 WD40 repeats 4kfm Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits 4kzx Rabbit 40S ribosomal subunit in complex with eIF1. 4kzy Rabbit 40S ribosomal subunit in complex with eIF1 and eIF1A. 4kzz Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A 4l9o Crystal Structure of the Sec13-Sec16 blade-inserted complex from Pichia pastoris 4lg8 Crystal structure of PRPF19 WD40 repeats 4lg9 Crystal structure of TBL1XR1 WD40 repeats 4mk0 Crystal structure of G protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative 4n14 4N14 4nsx Crystal Structure of the Utp21 tandem WD Domain 4o45 WDR5 in complex with influenza NS1 C-terminal tail 4o9d Structure of Dos1 propeller 4owr 4OWR 4ozu 4OZU 4pby 4PBY 4pbz 4PBZ 4pc0 4PC0 4pnk 4PNK 4psw 4PSW 4psx 4PSX 4ql1 4QL1 4qqe 4QQE 4r7a 4R7A 4u1e 4U1E 4u3m 4U3M 4u3n 4U3N 4u3u 4U3U 4u4n 4U4N 4u4o 4U4O 4u4q 4U4Q 4u4r 4U4R 4u4u 4U4U 4u4y 4U4Y 4u4z 4U4Z 4u50 4U50 4u51 4U51 4u52 4U52 4u53 4U53 4u55 4U55 4u56 4U56 4u6f 4U6F 4u7a 4U7A 4uer 4UER 4ug0 4UG0 4ui9 4UI9 4ujc 4UJC 4ujd 4UJD 4uje 4UJE 4v16 4V16 4v3p 4V3P 4v5o 4V5O 4v5z 4V5Z 4v6i 4V6I 4v6w 4V6W 4v6x 4V6X 4v7e 4V7E 4v7f 4V7F 4v7h 4V7H 4v7r 4V7R 4v88 4V88 4v8m 4V8M 4v8y 4V8Y 4v8z 4V8Z 4v92 4V92 4wjs 4WJS 4wju 4WJU 4wjv 4WJV 4x3e 4X3E 4x60 4X60 4x61 4X61 4x63 4X63 4xei 4XEI 4xf2 4XF2 4xfv 4XFV 4xmm 4XMM 4xmn 4XMN 4xyh 4XYH 4xyi 4XYI 4y7r 4Y7R 4ycz 4YCZ 4yhc 4YHC 4yvd 4YVD 4zn4 4ZN4 4zov 4ZOV 4zox 4ZOX 4zoy 4ZOY 4zoz 4ZOZ 5a1u 5A1U 5a1v 5A1V 5a1w 5A1W 5a1x 5A1X 5a1y 5A1Y 5a2q 5A2Q 5a31 5A31 5a5u 5A5U 5a9q 5A9Q 5afu 5AFU 5aj0 5AJ0 5ams 5AMS 5c9z 5C9Z 5ch1 5CH1 5ch2 5CH2 5cvl 5CVL 5cvn 5CVN 5cvo 5CVO 5cxb 5CXB 5cxc 5CXC 5cyk 5CYK 5dat 5DAT 5dc3 5DC3 5dfz 5DFZ 5eal 5EAL 5eam 5EAM 5eap 5EAP 5ear 5EAR 5em2 5EM2 5emj 5EMJ 5emk 5EMK 5eml 5EML 5emm 5EMM 5fa5 5FA5 5fci 5FCI 5fcj 5FCJ 5fl8 5FL8 5flc 5FLC 5flx 5FLX 5fvm 5FVM 5fxy 5FXY 5g04 5G04 5gan 5GAN 5gap 5GAP 5gm6 5GM6 5gmk 5GMK 5gxh 5GXH 5gxi 5GXI 5h1j 5H1J 5h1k 5H1K 5h1l 5H1L 5h1m 5H1M 5he0 5HE0 5he1 5HE1 5he2 5HE2 5he3 5HE3 5hqg 5HQG 5hyn 5HYN 5i4l 5I4L 5ic7 5IC7 5igo 5IGO 5igq 5IGQ 5ij7 5IJ7 5ij8 5IJ8 5it7 5IT7 5it9 5IT9 5jcs 5JCS 5jpq 5JPQ 5juo 5JUO 5jup 5JUP 5jus 5JUS 5jut 5JUT 5juu 5JUU 5juy 5JUY 5k0y 5K0Y 5k19 5K19 5k1a 5K1A 5k1b 5K1B 5k1c 5K1C 5kc2 5KC2 5kdo 5KDO 5khr 5KHR 5khu 5KHU 5l8e 5L8E 5l8w 5L8W 5l9t 5L9T 5l9u 5L9U 5lcw 5LCW 5lj3 5LJ3 5lj5 5LJ5 5lqw 5LQW 5lyb 5LYB 5lzs 5LZS 5lzt 5LZT 5lzu 5LZU 5lzv 5LZV 5lzw 5LZW 5lzx 5LZX 5lzy 5LZY 5lzz 5LZZ 5sxm 5SXM 5tdh 5TDH 5tee 5TEE 5tef 5TEF 5tf2 5TF2 5tga 5TGA 5tha 5THA - Links (links to other resources describing this domain)


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Bjarke Ingels designs central pavilion, with four other architects responsible for smaller projects
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With a wide range of options, features and colours, the Eclipse collection is square styling at its most beautiful. Available in new Brushed Gunmetal (PVD), plus Mirrored Black (PVD), Matte Black, and Chrome.
- All Pressure
- MP: 4 Star (6.5L/min)
- LP: 3 Star (8.5L/min)
- WaterMark Certified
- Physical Vapour Deposition (PVD)
- Brushed Gunmetal (PVD)
Please note that this supplier return policy includes a 20% return processing fee, which helps cover the costs associated with handling returnsItem, Allow 1-2 Days to order in
Frequently Asked Questions
How long will my order take
Once you place an order with us, if the item is in stock, we will dispatch any orders before 12pm same day. After 12PM the following day. Our couriers are usually overnight, however depending on the courier workload, it can take up to 5 working days.
Any Bigger items by Freight truck usually takes 1-4 working days North Island. 4-8 working days South Island.
What size waste do I need for my bath & basin?
Unless a plumber has speicified a different size,
Basin Wastes are 32MMBath wastes are 40MM
What colours do our custom pieces come in?
Our vanities are available in Melteca from NZ panels. Choose from the Bestwoods or Primepanels ranges. Are vanities are alos available in any Resene paint finish.
Our Stonetops can be made in any Smartstone or Uniquartz Colour.
What is the difference between a 12volt and 24volt heated rail and ladders?
What is Low Voltage?
According to the Australia and New Zealand Standards – Electrical Wiring Rules AS/NZS 3000:2018 low voltage is anything "Not exceeding 12 Volts AC or 30 Volts ripple-free DC".
What does "Wet Area Suitable" mean?
Products that are "Wet Area Suitable" have a suitable IP (Ingress Protection) rating that enables them to be installed in what is classified as Zone 1 in the bathroom. See Bathroom Zones
Bathroom Zones
The Australia and New Zealand Standard AS/NZS 3000:2018 identifies the zones in a bathroom and the IP rating required for electrical items installed in each zone. The illustration shown here is a guide only, for full details please refer to Australia and New Zealand Standard AS/NZS 3000:2018.


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Rotator Cuff Repair Surgeon in Texas
Rotator cuff tears are commonly caused by acute injuries or degenerative changes that occur slowly with age or overuse. Dr. Hayes provides diagnosis and individualized nonoperative and operative treatments for the shoulder including rotator cuff repair in Texas. Dr. Hayes also provides the highest level of care during and after surgery. Contact Dr. Hayes's office for an appointment today!
What is the Rotator Cuff?
The rotator cuff is a group of 4 muscles in the shoulder joint including the supraspinatus, infraspinatus, teres minor, and subscapularis. These muscles originate in the scapula and attach to the head of the humerus through tendons. The rotator cuff forms a sleeve around the humeral head and glenoid cavity, providing stability to the shoulder joint while enabling a wide range of movements.
Injury to the rotator cuff may occur due to pressure on the rotator cuff from part of the shoulder blade (scapula). It may occur due to repeated use of the arm for overhead activities or while playing sports. A forceful injury such as trauma can cause one or more of these tendons to tear, a condition called rotator cuff tear.
What is Rotator Cuff Repair?
Rotator cuff repair is a surgery to repair an injured or torn rotator cuff. It is usually performed arthroscopically on an outpatient basis. An arthroscope, a small, fiber-optic instrument consisting of a lens, light source, and video camera. The camera projects images of the inside of the joint onto a large monitor, allowing your doctor to look for any damage, assess the type of injury and repair it. Large rotator cuff tears may require open surgery.
When is Rotator Cuff Surgery Necessary?
Your doctor may suggest surgery to treat rotator cuff tears if you:
- do not respond to non-surgical treatment options
- have severe shoulder pain and experience loss of strength
- you want to return to sports soon
Preparing for the Surgery
Your doctor will assess your symptoms and take your medical history. Imaging tests such as X-ray, MRI or CT-scan may be ordered. Talk to your doctor about the medicines you are taking prior to the procedure and if you are allergic to any medicines or anesthesia. Arrange for someone to drive you home.
Surgical Procedure
The surgery is performed under general or regional and involves the following steps:
- One or more incisions are made at the skin near the shoulder joint.
- An arthroscope is inserted through the incision.
- Miniature surgical instruments are inserted to remove the damaged part of the tendon and injured surrounding tissue.
- The damaged ends of the tendon are sewn together. Care is taken to prevent damage to nearby nerves or blood vessels.
- A suture anchor may be used to reattach a completely torn tendon to the bone.
- The incision is closed and covered with a bandage.
Post-Operative Care
Prescription pain medicines or NSAIDs (non-steroidal anti-inflammatory drugs) are used to manage pain. Your shoulder will be placed in a brace or cast and you will be encouraged to keep weight off. You will be allowed to perform specific physical therapy exercises as you heal. You may return to normal activities after 6 months.
Risks and Complications
As with any surgery, there are associated risks and complications may occur. Those related to rotator cuff repair may include:
- Anesthetic complications
- Infection
- Nerve damage
- Stiffness
- Tendon re-tear
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Hubbard Radio Washington DC, LLC. All rights reserved. This website is not intended for users located within the European Economic Area.
Hubbard Radio Washington DC, LLC. All rights reserved. This website is not intended for users located within the European Economic Area.
A profile is emerging of Aaron Alexis, the man identified as the lone gunman in the mass shooting at the Washington Navy Yard in Washington, D.C., that left 13 ...
AP National Writer
Aaron Alexis seems a study in contradictions: a former Navy reservist, a Defense Department contractor, a convert to Buddhism who was taking an online course in aeronautics. But he also had flashes of temper that led to run-ins with police over shootings in Fort Worth, Texas, and Seattle.
A profile began to emerge Monday of the man authorities identified as the gunman in the mass shooting at the Washington Navy Yard in Washington, D.C., that left 13 people dead, including the 34-year-old man. While some neighbors and acquaintances described him as "nice," his father once told detectives in Seattle that his son had anger management problems related to post-traumatic stress brought on by the terrorist attacks of Sept. 11, 2001. He also complained about the Navy and being a victim of discrimination.
U.S. law enforcement officials told The Associated Press that Alexis had been suffering a host of serious mental issues, including paranoia and a sleep disorder. He also had been hearing voices in his head, the officials said. Alexis had been treated since August by the Veterans Administration for his mental problems, the officials said. They spoke on condition of anonymity because the criminal investigation in the case was continuing.
The Navy had not declared him mentally unfit, which would have rescinded a security clearance Alexis had from his earlier time in the Navy Reserves.
Family members told investigators Alexis was being treated for his mental issues.
At the time of the shootings, he worked for The Experts, a subcontractor on an HP Enterprise Services contract to refresh equipment used on the Navy Marine Corps Intranet network.
The company said on its website, "The Experts would like to express our deepest condolences and sympathies regarding the incident that occurred at the DC Naval Yards. We are actively cooperating with the FBI and other authorities in relation to the investigation on the suspect. Any additional information we have will be shared accordingly."
He was able to obtain a valid pass to the Navy Yard through his work as a contractor. The Washington Post reports Alexis was scheduled to begin working at the Washington Navy Yard this month.
His life over the past decade has been checkered.
Alexis lived in Seattle in 2004 and 2005, according to public documents. In 2004, Seattle police said Alexis was arrested for shooting out the tires of another man's vehicle in what he later described to detectives as an anger-fueled "blackout." According to an account on the department's website, two construction workers had parked their Honda Accord in the driveway of their worksite, next to a home where Alexis was staying. The workers reported seeing a man, later identified by police as Alexis, walk out of the home next to their worksite, pull a gun from his waistband and fire three shots into the rear tires of their Honda before he walked slowly back to his home.
When detectives interviewed workers at the construction site, they told police Alexis had stared at construction workers at the job site daily for several weeks prior to the shooting. The owner of the construction business told police he believed Alexis was angry over the parking situation around the site.
Police eventually arrested Alexis, searched his home, found a gun and ammunition in his room, and booked him into the King County Jail for malicious mischief.
According to the police account, Alexis told detectives he perceived he had been "mocked" by construction workers the morning of the incident. Alexis also claimed he had an anger-fueled "blackout," and could not remember firing his gun at the Honda until an hour after the incident.
Alexis also told police he was present during "the tragic events of Sept. 11, 2001" and described "how those events had disturbed him."
Then, on May 5, 2007, he enlisted in the Navy reserves, serving through 2011, according to Navy spokeswoman Lt. Megan Shutka.
Shutka said he received the National Defense Service Medal and the Global War on Terrorism Service Medal during his stint in the reserves. Both are medals issued to large numbers of service members who served abroad and in the United States since the 9/11 attacks. Alexis' last assignment was as aviation electricians mate 3rd class at the Naval Air Station Joint Reserve Base in Fort Worth, Shutka said.
Alexis had a string of misconduct problems during his nearly four years in the military, but he received an honorable discharge, U.S. officials said Tuesday.
The officials told the Associated Press Alexis had bouts of insubordination, disorderly conduct and was sometimes absent from work without authorization. The offenses occurred mainly when he was serving in Fort Worth, Texas, from 2008-2011, and were enough to prompt Navy officials to grant him an early discharge through a special program for enlisted personnel.
Officials said the bad conduct made it clear Alexis would not be a good sailor, but not enough to warrant a general or less-than-honorable discharge. They also did not involve criminal offenses, so did not trigger any court-martial proceedings.
The officials spoke on condition of anonymity because they were not authorized to discuss his record publicly.
It was while he was still in the reserves that a neighbor in Fort Worth reported she had been nearly struck by a bullet shot from his downstairs apartment.
In September 2010, Fort Worth police questioned Alexis about the neighbor's report. He admitted to firing his weapon but said he was cleaning his gun when it accidentally discharged. He said he did not call the police because he didn't think the bullet went through to the other apartment. The neighbor told police she was scared of Alexis and felt he fired intentionally because he had complained about her making too much noise.
Alexis was arrested on suspicion of discharging a firearm within city limits but Tarrant County district attorney's spokeswoman Melody McDonald Lanier said the case was not pursued after it was determined the gun discharged accidentally.
After leaving the reserves, Alexis worked as a waiter and delivery driver at the Happy Bowl Thai restaurant in White Settlement, a suburb of Fort Worth, according to Afton Bradley, a former co-worker. The two overlapped for about eight months before Alexis left in May, Bradley said.
Having traveled to Thailand, Alexis learned some Thai and could speak to Thai customers in their native language.
"He was a very nice person," Bradley said in a phone interview. "It kind of blows my mind away. I wouldn't think anything bad at all."
A former acquaintance, Oui Suthametewakul, said Alexis lived with him and his wife from August 2012 to May 2013 in Fort Worth, but that they had to part ways because he wasn't paying his bills. Alexis was a "nice guy," Suthametewakul said, though he sometimes carried a gun and would frequently complain about being the victim of discrimination.
Suthametewakul said Alexis had converted to Buddhism and prayed at a local Buddhist temple.
"We are all shocked. We are nonviolent. Aaron was a very good practitioner of Buddhism. He could chant better than even some of the Thai congregants," said Ty Thairintr, a congregant at Wat Budsaya, a Buddhist temple in Fort Worth.
Thairintr said Alexis told him he was upset with the Navy because "he thought he never got a promotion because of the color of his skin. He hated his commander."
As Thairintr and others at the temple understood, Alexis took a job as a contractor and he indicated to them he was going to go to Virginia. He last saw him five weeks ago.
"He was a very devoted Buddhist. There was no tell-tale sign of this behavior," Thairintr said.
In the early 2000s, before he moved to Seattle, Alexis lived with his mother in an apartment in Queens, N.Y., said Gene Demby, of Philadelphia, who said he dated one of Alexis' younger sisters at the time. He said Alexis and his two younger sisters had a difficult relationship with their father, who divorced their mother in the mid-1990s.
"I wouldn't call him nice, but he seemed harmless, if really awkward," said Demby, the lead writer for NPR's Code Switch blog about race and culture. "He was insecure. He was like a barbershop conspiracy theorist, the kind of guy who believes he's smarter than everyone else. He also was kind of like perpetually aggrieved, but not megalomaniacal or delusional."
Embry-Riddle Aeronautical University, which offers online courses in aviation and aerospace, confirmed that Alexis was enrolled as an online student via its Fort Worth campus, started classes in July 2012 and was pursuing a bachelor's of science in aeronautics.
"We are cooperating fully with investigating officials," the university said.
Associated Press writers Mike Baker and Phuong Le in Seattle, Nomaan Merchant in Dallas, John L. Mone in White Settlement, Texas, and Matt Apuzzo, Adam Goldman, Lolita C. Baldor, Ben Nuckols and Brett Zongker in Washington contributed to this report.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
(Federal News Radio contributed to this report.)
13 confirmed dead at Washington Navy Yard, shooter identified
DC Police release names of victims
Shooting a grim reminder of dangers of federal service
Copyright © 2024 Federal News Network. All rights reserved. This website is not intended for users located within the European Economic Area.


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Few senior-executive positions will be subject to as much change over the next few years as that of the chief marketing officer. Many CEOs and boards may think that their senior marketers' hands are already full managing the rise of new media, the growing number of sales and service touch points, and the fragmentation of customer segments.1 But as the forces of marketing proliferation gather strength, what's actually required is a broadening of the CMO's role. This expansion will encompass both a redefinition of the way the marketing function performs its critical tasks and the CMO's assumption of a larger role as the "voice of the customer" across the company as it responds to significant changes in the marketplace.
Critical contributors to the broadening mission of marketers include the Internet and evolving distribution models, which are profoundly changing the way consumers research and buy products. In addition, third parties such as bloggers and the creators of user-generated media are having a greater influence on corporate reputations. Finally, marketers must help companies find and meet the unique needs of an ever more diverse and global customer base. Taken together, these forces are making companies transform not just the marketing function but also everything from corporate affairs and product development to distribution and manufacturing models.
Because changing customer needs and behavior underlie many of these shifts, CMOs are a natural choice to spearhead the response. Yet many of them find themselves limited by narrowly defined roles. Meanwhile, CEOs and board members, who have been pushing CMOs hard for growth and for more effective marketing efforts, are frustrated by the difficulty of finding chief marketers with the full range of necessary skills. Turnover rates for CMOs are therefore high relative to those of their C-level peers, and CMOs are in short supply. (Just ask any executive recruiter about the number of difficult CMO searches he or she has under way.)
To succeed in this new environment, companies must do two things. First, they need to clarify the broadened role of marketing in general and the CMO in particular. The accelerating pace of change is creating a wide range of potential new priorities for chief marketers—leading change efforts across the whole corporation, playing a more active role in shaping the company's public profile, helping to manage complexity, and building new capabilities within (and even outside of) the marketing department. Second, as the roles of marketing and the chief marketer expand, it will become critical for CEOs to ensure that they have the right person as CMO, to understand fully how customers are changing, and to become more involved in developing new marketing capabilities across the company.
Winds of change
The biggest shift in today's marketing world isn't the much-discussed declining effectiveness of television advertising but the changes in how consumers research and buy products. The Internet is a major contributor to this shift. In categories as diverse as electronics, financial services, and health care, consumers increasingly ignore push marketing, preferring instead to use the Internet to research products and decide which ones to buy. Over half of all US electronics consumers, for example, now rely on Web-based research to narrow the choice of brands and largely ignore the advice of the sales staff when choosing among products in stores. In 2005 nearly half of customers who purchased insurance researched the subject online before talking to agents, and 80 percent expected to do so within five years. Currently, almost 60 percent of aging baby boomers use the Internet to supplement their doctors' advice.
But the change in consumer buying habits is broader. The proliferation of distribution touch points and the more rapid growth of the low and high ends of the market at the expense of the middle are forcing marketers to take low-cost, time-saving, "facts-only" sales approaches and, at the same time, higher-value, more service-oriented approaches, often through alternative distribution channels. A white-goods manufacturer, for example, might need to provide different products, forms of sales support, and even subbrands for mass merchandisers, traditional department stores, and high-end retailers, respectively, to reach customers with different price sensitivities and definitions of value.
The result is a wide range of challenges. One vexing issue for marketers: many new media that seem to be promising ways of gaining access to consumers as they conduct their research are not yet at scale. The result is fragmented media spending and, sometimes, rising costs to generate the desired consumer impact. A broader issue is that marketers must work more intensively than they have in the past with colleagues in other functions to develop, deliver, and communicate value propositions to consumers who want independent advice and frequently aren't willing to pay for higher-touch sales and service. Consider, for example, the white-goods manufacturer mentioned above. Changing customer needs (which marketers understand) create an opportunity to boost sales, but manufacturing, marketing, and sales must cooperate if the company is actually to win big among all three types of retailers.
Shifting patterns of buying behavior coincide with another seismic change: the increased role of third parties in corporate-marketing and reputation-building efforts. While third parties (such as Consumers Union, the publisher of Consumer Reports magazine) have been around for years, the Internet's growth has tremendously increased the importance of user-generated media (for instance, blogs, independent sites such as Wikipedia, and YouTube and other video-sharing sites). User-generated media account for almost one-third of all the time individuals spend on the 100 most visited US Web sites, up from roughly 3 percent just two years ago. Consumers skeptical of push ads are flocking to a medium they trust more.
Although good for consumers, this explosion of user-generated content comes with big risks for business. Individuals and nongovernmental organizations that don't fully understand the products of a company, and may be purposefully trying to harm it, can sometimes have as much (if not more) influence over its image as its marketing communications unit. User-generated media, while a long-term marketing opportunity, are thus proving to be a short-term PR nightmare for many companies. Who, for example, can forget the YouTube video clip featuring a cable TV technician sleeping on a couch?
As if these changes weren't difficult enough, the underlying customer needs that companies must understand and meet while they pursue growth in new (and often less-developed) markets are changing as well. Emerging markets are grabbing a larger share of global GDP, and the developed economies' middle market (which many marketers have historically targeted) is stagnating.2 Growth-hungry marketers must therefore learn how to understand and capitalize on the needs of new markets, segments, and consumers, including people with incomes much lower than those that most marketers were accustomed to in the past.3
The CMO's changing role
As companies confront changing consumer behavior, increasingly important third-party scrutiny, and more diverse target markets and segments, they must broaden the roles of marketing and the CMO. Today, many chief marketers focus mainly on building brands, making advertising more effective, and perhaps market research. Although these responsibilities aren't going away, CMOs must address several other areas as well: leading company-wide change in response to evolving buying patterns, stepping up efforts to shape a company's public profile, managing complexity, and building new marketing capabilities throughout the company as a whole. The relative importance of these new priorities will of course vary by company and industry, but the broad importance of reinventing the CMO's role as a strategic activist is similar across them.
Changing to reflect new consumer buying behavior
Consumers knowledgeable about and comfortable with online research and sales will make many companies change their business models. Pharmaceutical companies, for example, must rethink the way the field force calls on physicians, who are becoming a less important influence on the consumer's health care choices. Retailers need to design stores that integrate the Internet's broader selection with the brick-and-mortar approach (as some are now doing with in-store kiosks). In general, there's a need for tighter integration between corporate marketing and sales as Web-based channels expand their role in advertising, sales, and marketing.
The resulting business changes will extend far beyond traditional marketing: a company won't succeed without heeding the voice of customers and their evolving habits in buying goods and services and in interacting with companies and brands. The CMO is a natural candidate to help lead the company as a whole toward business changes that reflect evolving customer needs. It is, for example, the marketing department that is likely to develop (as Toyota Motor has done) programs to position a company in online communities such as Second Life, the leading virtual marketplace, which provides low-cost opportunities to learn how role-playing consumers would design and use new products.
This tight relationship between marketing and critical business changes extends to emerging markets, whose growing importance will place exacting demands on the entire organization to develop, produce, and deliver lower-cost goods and services. A deep understanding of the needs of consumers in these markets and the trade-offs they make will be critical in designing products and retail formats that strike the right balance between price and quality. Since engineers and store design teams in developed markets probably won't have the needed insight, CMOs will have to develop partners and capabilities to tap into high-quality local sources of customer information. Nokia's development of low-cost mobile phones for India and P&G's success with toothpaste in China show how companies can translate insights about local consumers into growth in emerging markets.4
Shaping the company's public profile
The increasing importance of third parties will force businesses to enhance their awareness of blogs, chat rooms, and other social-networking media and to develop new strategies both to capitalize on marketing opportunities revealed by consumers and to defend themselves from attacks. Many companies will find that their initial efforts will be defensive ones involving changes to the tried-and-true approach for managing their public profile.
Traditionally, companies have tended to separate marketing (focused on customers) from corporate affairs (addressing government officials), investor relations (catering to financial analysts), and public relations (targeting the press). Often these groups report to different executives—marketing to the CMO, investor relations to the CFO, and corporate affairs (and perhaps also public relations) to a corporate secretary. But consider the following scenario: a nongovernmental organization erroneously complains on its blog that a company is illegally using below-minimum-wage labor to make critically important products. Within days, major media and Internet sites have questioned the truthfulness of the company and the quality of its products, government officials have expressed concern, and its stock has tanked. Who responds? What in the past might have been a PR issue now requires an integrated response across marketing, PR, investor relations, and public affairs.
Over the past few years, McKinsey has been involved firsthand with several large organizations trying to shift their public image. In our experience, classic marketing techniques (such as segmentation and understanding the sources of consumers' opinions) are the foundation of a corporate-image strategy. Public-relations and lobbying campaigns may be the necessary tactics, but any strategy should be based on classic consumer research. Most corporate-affairs executives don't have the background to lead this type of effort and therefore increasingly turn to their marketing counterparts for assistance. CMOs are the natural coordinators of an integrated effort because they understand customers and sophisticated marketing techniques.
Managing complexity
With more countries, more customer segments, more media, and more distribution channels, companies and their CMOs are waging a battle with complexity (see sidebar, "How consumer goods CMOs are coping with complexity"). Consider prices: to set them effectively, consumer companies operating in a number of channels and geographies must address the needs of dozens of segments and make rapid, analytically informed decisions about as many as 20 million individual price points a year.5 Many companies are developing new approaches to manage this complexity. Most choose to give final pricing authority to the managers accountable for the performance of a brand or geography, supporting them with centrally established processes and policies to ensure consistency across segments and geographies. Small analytic groups often are crucial to ensure the collection and analysis of the pricing data needed to make good decisions.
One key challenge is reconciling local entrepreneurship with global and cross-segment brand consistency. While the ultimate pricing decisions typically (and appropriately) remain with the business units accountable for profits, some CMOs are beginning to play a critical role in developing data-management tools and processes that help companies to maintain a consistent brand image and to support it despite growing complexity. One such company is a multibrand automotive-battery manufacturer that sells its products through a number of retail channels, including national and regional auto parts retailers, discount mass merchandisers, and warehouse clubs. Its CMO used the real-time reporting of average and lowest net retailer prices by region, channel, and even specific sales outlets to maintain the right price differentials among them. This CMO regularly interceded in pricing and at times even chose to optimize it within a specific region in order to maintain critical price relationships among the various channels, brands, and regions.
Building new marketing capabilities
The changing environment calls for new marketing capabilities, both in the marketing organization and in the company as a whole. Within marketing, for example, the ability to build brands across an increasing number of media, including vehicles dominated by user-generated content, will be critical. Many companies will have to manage an increased number of advertising and PR agencies and to build new skills for creating integrated messages. There also will be analytic muscles to build, such as the data-management skills needed to compare and maximize the effectiveness of on- and offline marketing expenditures.
Many of these skills, such as expertise in the business use of social networking, in digital marketing, or in emerging markets, require a degree of specialization that complements the generalist capabilities of traditional marketing managers. As a result, many companies will be forced to restructure their marketing and sales organizations by creating centers of excellence for key marketing capabilities and, perhaps, by outsourcing marketing activities requiring specialized skills, just as some CIOs rely on external IT-development resources. Not surprisingly, almost 75 percent of the chief marketers polled at a recent CMO summit (organized by the Marketing Science Institute and McKinsey) agreed that the skills they needed were becoming so specialized that their organizations would have to operate quite differently in the future.
The skill-building challenges of CMOs probably won't stop in their own departments—the far-reaching customer-centric changes taking place today are too important. As we move toward a world where 80 percent of life insurance purchasers research the subject online, for example, sales agents seeking to understand their customers must learn to ask them new questions: Have they researched online? What sites did they visit? What impressions of different brands do they have? Public-relations and even general managers need to understand which third parties influence their customers most and what responses work if ill-informed discussions start there. The CMO and the marketing organization have the best position to provide market research and training and to help with the creation of appropriate responses and the required capabilities. It's not surprising, therefore, that some companies are asking their CMOs to establish "commercial councils" across business units to coordinate their marketing and customer efforts.
How CEOs can help
CMOs are indispensable for meeting tomorrow's customer and marketing challenges. But CEOs too must take an active role, not just because those challenges are large, but also because close involvement will help them know if their CMOs have the right mix of skills. Today, though, many CEOs spend little time on marketing challenges and treat them as "just for the CMO." One reason: the percentage of CEOs with marketing backgrounds has declined in favor of people from operations or finance. Here are three straightforward ideas for CEOs seeking to help their CMOs and ensure that their companies thrive:
Take time to understand what's really happening with customers. Many of today's marketing reviews focus on the brand image and financial results. Instead, find out how the needs of different customer segments are evolving, who is saying what to your customers on which blog, who are the social influencers of your product, and how customers are changing their approach to decision making. On these issues, advances in technology allow companies to obtain a level of insight that is staggering compared with what was possible just three years ago. CEOs can add a lot to such a customer-oriented discussion, but only if they take the time to participate. Gary Loveman, the CEO of the casino operator Harrah's, for example, has been deeply involved in his company's efforts (involving sophisticated customer relationship management techniques) to boost the loyalty of its customers.6
Foster the right connection between the CMO's efforts and those of the other parts of the organization. This connection is not only critical for bringing together marketing, PR, and corporate affairs but also important when CMOs are asked to lead major corporate initiatives on strategy and business models. Without the right bridges between the CMO and the heads of business units, the latter tend to view such projects as corporate-staff efforts and therefore delegate participation in them to lower-ranking employees. Ensuring an effective rotation of senior marketers into line roles (and having future general managers spend time in marketing ones) can help break down barriers and infuse a marketing orientation into the entire company. Two of the four senior marketers in the accompanying roundtable (see "Confronting proliferation: A conversation with four senior marketers"), for instance, recently shifted from roles leading marketing and sales to positions with broader responsibilities (John Fleming as Wal-Mart's chief merchandising officer and Alex Myers as head of Carlsberg's business in Western Europe).
Be a "thought partner" for the CMO as he or she transforms the marketing organization. A lot of change—skill building, the development of specialists, and geographic decentralization—will be required to create the marketing organization of the future. Even a CEO who lacks a marketing background typically has more experience with this type of organizational-development effort than the CMO does—and can be an extremely valuable counselor.
No relief is in sight for companies wrestling with the forces of proliferation. In the years ahead, an accelerating pace of change will continue to transform the role of marketing and the CMO and their relationship with the corporation as a whole.