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Healthcare Industry News: teriflunomide
News Release - January 28, 2013
Genzyme's LEMTRADA(TM) (alemtuzumab) Application for MS Accepted for Review by the FDA
Genzyme Also Reports Very Encouraging Early Launch Indicators for AUBAGIO® (teriflunomide) in U.S.CAMBRIDGE, Mass.--(Healthcare Sales & Marketing Network)--Genzyme, a Sanofi Company (EURONEXT: SAN and NYSE: SNY), announced that the U.S. Food and Drug Administration (FDA) has accepted for review the company's supplemental Biologics License Application (sBLA) file seeking approval of LEMTRADA (alemtuzumab) for the treatment of relapsing multiple sclerosis (RMS). The company also reported key highlights from the U.S. launch of once-daily, oral AUBAGIO (teriflunomide).
LEMTRADA sBLA Accepted by FDA
The FDA has accepted for standard review the company's sBLA file seeking approval of LEMTRADA. Genzyme expects FDA action on the application in the second half of 2013. Genzyme has already submitted its marketing authorization application for LEMTRADA to the European Medicines Agency (EMA) and the review process is underway. The Committee for Medicinal Products for Human Use (CHMP) opinion for LEMTRADA is expected in Q2 2013.
The LEMTRADA clinical development program includes CARE-MS I and CARE-MS II (Comparison of Alemtuzumab and Rebif®Efficacy in Multiple Sclerosis), randomized Phase III studies comparing LEMTRADA to a standard of care MS treatment, Rebif,in patients with relapsing-remitting MS who were naïve to prior treatment or who had relapsed while on prior therapy, respectively. Genzyme announced publication of results of these studies in The Lancet in November 2012.
AUBAGIO Early Launch Indicators in the U.S.
Since its launch in October, once-daily, oral AUBAGIO has shown very encouraging early launch indicators among U.S. prescribers.1 Key highlights from the launch include:
More than 80 percent of MS specialists in the U.S. have prescribed AUBAGIO;
Approximately 1 in 5 patients prescribed AUBAGIO were treatment-naïve;
More than 50 percent of AUBAGIO patients were most recently on Copaxone® or Avonex®
"Genzyme is making a difference for people living with MS and realizing its vision of being leaders in MS," said Genzyme President and CEO, David Meeker, M.D. "The initial uptake of AUBAGIO by U.S. prescribers shows the importance of a once-daily oral option in MS. In addition, the acceptance of the LEMTRADA file in the U.S. marks another important milestone in bringing this potentially transformative therapy to MS patients. We look forward to a series of product launches in 2013 in Europe and other major markets."
AUBAGIO is approved for use in both the U.S. and Australia.
About Alemtuzumab/LEMTRADA™
Alemtuzumab is a monoclonal antibody that selectively targets CD52, a protein abundant on T and B cells. Treatment with alemtuzumab results in the depletion of circulating T and B cells thought to be responsible for the damaging inflammatory process in MS. Alemtuzumab has minimal impact on other immune cells. The acute anti-inflammatory effect of alemtuzumab is immediately followed by the onset of a distinctive pattern of T and B cell repopulation that continues over time, rebalancing the immune system in a way that potentially reduces MS disease activity.
Genzyme holds the worldwide rights to alemtuzumab and has primary responsibility for its development and commercialization in multiple sclerosis. Bayer HealthCare retains an option to co-promote alemtuzumab in multiple sclerosis. Bayer HealthCare has notified Genzyme of its intention to co-promote under this option. Upon regulatory approval and commercialization, Bayer would receive contingent payments based on sales revenue.
LEMTRADATM is the proprietary name submitted to health authorities for the company's investigational multiple sclerosis agent alemtuzumab.
About AUBAGIO®
AUBAGIO is an immunomodulator with anti-inflammatory properties. Although the exact mechanism of action for AUBAGIO is not fully understood, it may involve a reduction in the number of activated lymphocytes in the central nervous system (CNS).
Indications and Usage
AUBAGIO (teriflunomide) is a once-daily, oral treatment indicated for patients with relapsing forms of multiple sclerosis (MS). AUBAGIO 14 mg has shown significant efficacy across key measures of MS disease activity, including reducing relapses, slowing the progression of physical disability, and reducing the number of brain lesions as detected by MRI.
Important Safety Information About AUBAGIO
The AUBAGIO label includes a boxed warning citing the risk of hepatotoxicity and, teratogenicity (based on animal data).
In MS clinical studies with AUBAGIO, the incidence of serious adverse events were similar among AUBAGIO and placebo-treated patients. The most common adverse events associated with AUBAGIO in MS patients included increased ALT levels, alopecia, diarrhea, influenza, nausea and paresthesia.
teriflunomide is the principal active metabolite of leflunomide, which is indicated in the U.S. for the treatment of rheumatoid arthritis. Severe liver injury including fatal liver failure has been reported in patients treated with leflunomide.
Leflunomide has an estimated 2.1 million years of patient exposure in rheumatoid arthritis globally since its launch.
AUBAGIO is contraindicated in pregnant women and women of childbearing potential who are not using reliable contraception.
AUBAGIO is supported by a robust clinical program with more than 5,000 trial participants in 36 countries and is amongst the largest of any MS therapy. Some patients in extension trials have been treated for up to 10 years. The AUBAGIO approvals were based on efficacy data from the TEMSO (teriflunomide Multiple Sclerosis Oral) trial.
For full prescribing information and more information about AUBAGIO, please visit www.genzyme.com.
About Genzyme, a Sanofi Company
Genzyme has pioneered the development and delivery of transformative therapies for patients affected by rare and debilitating diseases for over 30 years. We accomplish our goals through world-class research and with the compassion and commitment of our employees. With a focus on rare diseases and multiple sclerosis, we are dedicated to making a positive impact on the lives of the patients and families we serve. That goal guides and inspires us every day. Genzyme's portfolio of transformative therapies, which are marketed in countries around the world, represents groundbreaking and life-saving advances in medicine. As a Sanofi company, Genzyme benefits from the reach and resources of one of the world's largest pharmaceutical companies, with a shared commitment to improving the lives of patients. Learn more at www.genzyme.com.
About Sanofi
Sanofi, a global and diversified healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients' needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and the new Genzyme. Sanofi is listed in Paris (SAN) and in New York (SNY).
Genzyme® is the registered trademark of Genzyme Corporation. All rights reserved.
Copaxone® is a trademark of Teva Pharmaceuticals Industries.
Avonex® is a trademark of Biogen Idec.
Rebif® is a registered trademark of EMD Serono, Inc. or affiliates.
About Bayer HealthCare
The Bayer Group is a global enterprise with core competencies in the fields of health care, nutrition and high-tech materials. Bayer HealthCare, a subgroup of Bayer AG with annual sales of EUR 17.2 billion (2011), is one of the world's leading, innovative companies in the healthcare and medical products industry and is based in Leverkusen, Germany. The company combines the global activities of the Animal Health, Consumer Care, Medical Care and Pharmaceuticals divisions. Bayer HealthCare's aim is to discover, develop, manufacture and market products that will improve human and animal health worldwide. Bayer HealthCare has a global workforce of 55,700 employees (Dec 31, 2011) and is represented in more than 100 countries. Find more information at www.bayerhealthcare.com.
Sanofi Forward Looking Statements
This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates and their underlying assumptions, statements regarding plans, objectives, intentions and expectations with respect to future financial results, events, operations, services, product development and potential, and statements regarding future performance. Forward-looking statements are generally identified by the words "expects", "anticipates", "believes", "intends", "estimates", "plans" and similar expressions. Although Sanofi's management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties inherent in research and development, future clinical data and analysis, including post marketing, decisions by regulatory authorities, such as the FDA or the EMA, regarding whether and when to approve any drug, device or biological application that may be filed for any such product candidates as well as their decisions regarding labelling and other matters that could affect the availability or commercial potential of such product candidates, the absence of guarantee that the product candidates if approved will be commercially successful, the future approval and commercial success of therapeutic alternatives, the Group's ability to benefit from external growth opportunities, trends in exchange rates and prevailing interest rates, the impact of cost containment policies and subsequent changes thereto, the average number of shares outstanding as well as those discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in Sanofi's annual report on Form 20-F for the year ended December 31, 2011. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.
1 Based on data collected at Genzyme's MS One to One Patient and Provider Support Center, September 2012-January 2013.
Source: Genzyme
Issuer of this News Release is solely responsible for its
Please address inquiries directly to the issuing company.


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We're now at the half way mark in our short series of sonically upgraded and content-expanded reissues of original Millie Jackson Spring albums. The recently released makeovers of "Caught Up" and "Still Caught Up" have been as well received as we had hoped they would be, both by long time Millie fans and new recruits to the MJ cause alike. Next month will see these two joined by Millie's first really big album, 1973's "IT HURTS SO GOOD". Before that, we're delighted to bring you a sublimely revamped version of her Spring debut, first released in the late Summer of 1972 and sounding as good as ever in this new expanded edition.
By 1974, Millie was able to call all her own career shots at Spring, including picking her own repertoire and co-producing her own sessions. But at her early sessions she was, as she told me recently, "doing whatever I was told " by, mostly, Spring's in-house songwriter-producer Raeford "Ray Godfrey" Gerald, who selected - and indeed wrote or co-wrote – a good number of the sides that Millie cut on her first three Spring albums. The fact that Millie had co-written A Child Of God, though, gave her an input that many new artists wouldn't have got on their debut releases, and her lively personality shines through on every one of the album's 10 tracks - even those she didn't like.
As with many other soul albums of the time, there was no actual 'concept' about "Millie Jackson". Spring brought together the As and Bs of Millie's singles to date, augmented them with the two tracks that would become a fourth single from the album and added a couple of 'extras' that might or might not be used as flips to future 45s. Such was the quality of this repertoire, however, that Millie's debut album sounded no less disjointed than the run of concept albums that were still a few years in her future. In less than two years, those four singles and the attendant album took our heroine from being a shipping clerk-cum-catalogue model, with one failed single and a part time singing career, to being one of the leading names in contemporary soul music.
"Millie Jackson" has been remastered from the original first generation tape that was used to cut the stampers from which the original vinyl album was made. A generous nine bonus tracks have been added to give the expanded CD a running time which doubles that of the original album. Four of these will be of particular interest to MJ completists, being the four tracks that she cut for Suron Productions in 1969. These were originally leased to MGM Records before Spring acquired them in the early 1970s. Two, A Little Bit Of Something and My Heart Took A Licking formed Millie's debut 45 release, but the other two have remained unheard for 37 years. Actually, only Licking has ever been reissued previously, so this CD marks the first time that all four have appeared together in one compilation.
The other previously unissued material showcases alternate (sometimes VERY alternate!) versions of material that every Millie fan will be familiar with. I'll let you discover the differences on most of these yourselves, but I can't leave the topic without commenting favourably on the early version of Hypocrisy – which was re-recorded for Millie's next album with a different lyric and, to my mind, a far less funky groove. For many people these bonus cuts will be worth the (extremely reasonable) price of this CD on their own.
Having penned all the sleeve notes to the CDs in this series, as well as each individual RT piece, I reckon that I'll have written close on 30,000 words on Millie Jackson by the time the series finishes with the forthcoming upgrade of "Feelin' Bitchy" (CDSEWM 242). Considering how many I've used along the way, I find that I experience no problems when it comes to finding new superlatives to heap upon Thoroughly Marvellous Millie. One listen to this CD will show you exactly why this is so.
By Tony Rounce

subset: commoncrawl


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Partner & Director, Creativity & Scenarios
New York
Related Expertise: Innovation Strategy and Delivery, Strategic Planning
By Alan Iny and Luc de Brabandere
Thinking creatively about the future requires sensitivity to the complex, fast-moving world in front of you, the ability to anticipate unexpected disruptions, and a willingness to constantly reevaluate your most basic beliefs and assumptions. Done well, we believe thinking creatively about the future of organizations requires doing three things:
First, understand how people think.
The brain's hard-wiring could be leading you and your colleagues to hold on to tired assumptions and misperceptions about your organization. People have a natural bias toward ideas and concepts that confirm, as opposed to contradict, ideas they already believe. Such biases can sabotage their capacity for fresh thinking.
A classic example: Henry Ford famously insisted that the all-black Model T would always remain desirable to consumers. Even as other automakers created new car models and colors, even when his colleagues urged him to consider pursuing new directions, Ford refused to budge. After years of fantastic innovations that helped bring the automobile to the masses, Ford fell prey to the "anchoring" bias that leads people to make (or fail to make) new decisions by referencing their prior experiences.
Free your mind to generate new ideas by noticing how these and other cognitive patterns may be shaping your key assumptions and holding you back from thinking in more creative ways.
When thinking about the future of your organization, you and your colleagues must feel encouraged to doubt whether "the way we do things here at X Corp." is necessarily still relevant. Insist upon a culture that allows people to constantly challenge the most fundamental beliefs, hypotheses, and assumptions that they have about your organization, the industry in which it does business, and the world in which it operates.
Second, think creatively by developing new mental models; audit—and then question—your organization's fundamental beliefs and assumptions.
To think creatively is to change the way you look at something, to update one or more of your mental models. To get started, drill down on some of the most important mental models that you and your colleagues are currently using. Consider conducting a "beliefs audit." By interviewing or surveying your colleagues, you can probe their thoughts about your organization's current situation:
These are only sample questions—you should develop others based on the current needs of your organization.
Questioning your current situation can open up paths to creative thinking. For instance, Google's original aspiration was to build the best search engine ever; arguably the organization achieved that. But in order to enter a new era of growth, Google leaders needed to perceive their company differently. Only when they challenged their long-held assumption that "We are a search engine company" could they then come up with the "We want to know everything" notion, which sparked projects such as Google Earth, Google Book Search, and Google Labs, along with further improvements to their fabled search engine.
Third, think creatively about the future by using "prospective thinking" to consider key trends and disruptions.
Take an expansive, long-term view, open to all possibilities and fully aware of what's happening both within and outside of your organization or your immediate environment.
Megatrends, large social, economic, political, environmental, or technological changes likely to have major impact across a wide range of areas, can be a very useful tool to help spark new possibilities. Examples include the rise of alternative energy sources, rapidly developing markets like Brazil and China, and increasing mobile connectivity. Megatrends will affect your company, your customers, your competition, as well as your family and community.
Develop a list of issues you believe will likely play out over a relatively long period of time (five to ten years, say, though different industries could have longer or shorter timeframes); have a strong and wide-reaching impact; and open up a range of strategic responses on your part. Then, refine your list by asking: Which trends will be the key vectors for shaping my organization's future? What are some of the seemingly irrelevant trends that could end up being surprisingly critical?
Ponder the many ways you could exploit these megatrends to create new opportunities for your organization. Stretch your thinking by considering which of these trends your organization would be the least ready to deal with. Are there trends right in front of you that you haven't yet addressed?
Ask yourself how these potential trends could influence the new ideas you want to generate for the future. For example, a client we worked with several years ago, a major European department-store chain, stated emphatically that its future was in China, based on trends outlining the increased purchasing power of the rising middle class there. But not a single person on the leadership team had heard of TaoBao, the closest Chinese analogue to Amazon.com, which was growing at double-digit rates, building new distribution centers across the country, and focusing on customer relationships and loyalty.
Thinking creatively about the future is not only about gathering the trend data but maintaining the atmosphere of doubt cultivated in the first step. This will enable you to look at data—whether trends, customer research, or competitive intelligence—in fresh ways, to be better prepared for an uncertain future. Indeed, thinking creatively about the future means embracing the uncertainty, rather than the more predictable response of trying to remove it.
This commentary originally appeared on HBR.org.
Boston Consulting Group partners with leaders in business and society to tackle their most important challenges and capture their greatest opportunities. BCG was the pioneer in business strategy when it was founded in 1963. Today, we work closely with clients to embrace a transformational approach aimed at benefiting all stakeholders—empowering organizations to grow, build sustainable competitive advantage, and drive positive societal impact.
Our diverse, global teams bring deep industry and functional expertise and a range of perspectives that question the status quo and spark change. BCG delivers solutions through leading-edge management consulting, technology and design, and corporate and digital ventures. We work in a uniquely collaborative model across the firm and throughout all levels of the client organization, fueled by the goal of helping our clients thrive and enabling them to make the world a better place.
© Boston Consulting Group 2024. All rights reserved.
For information or permission to reprint, please contact BCG at firstname.lastname@example.com. To find the latest BCG content and register to receive e-alerts on this topic or others, please visit bcg.com. Follow Boston Consulting Group on Facebook and X (formerly Twitter).


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Curvy Chronicles
Welcome to True Corset's, Curvy Chonicles
The Curvy Chronicles are a series of videos specifically for the fuller figure and plus sizes.
Our aim is to have fun while informing, educating and answering questions that relate to the fuller figure or plus sizes.
This is still a work in progress and more videos are added weekly.
If you'd like us to cover anything in particular, please do drop us a line and we will be happy to create an episode to cover that subject
Episode 1 - Corsets for your body type - Apple
The main body types and which corsets work best for the apple figure.
Episode 2 - Styling your corset
The different ways you can wear your corset, from stealthing and beyond.
Episode 3 - Corsets for your body type - Pear
The main body types and which corsets work best for the pear figure.


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Opal Iridescent Sri Yantra Stretch Bracelet
The Sri Yantra comes from the Hindu and Buddhist traditions and has been known since the Vedic times as the most powerful, mystical, and beautiful of all yantras (geometric mandalas known as power diagrams).
It represents the timeless principle of the universe and is used as an object of meditation. Sri Yantra is also known as the Goddess of wealth and prosperity.
7" stretch bracelet with sri yantra bead


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NanoSTIX is Malaysia's pioneer manufacturer for close-pod electronic cigarettes technology which was founded in January 2017. Headquartered in Malaysia, the company has established the business by selling over 800k units over the past 2 years. NanoSTIX's main goal is to create a world free of cigarette by helping others stop smoking. In terms of design, NanoSTIX device is handy and easy to carry everywhere. Our NanoPOD produces less smoke compared to others. Fantasy Lab, a subsidiary company by NanoSTIX Venture is helping billions of smokers to quit smoking using the first and fastest TRT (Tobacco Replacement Therapy) product that was able to help smokers to stop smoking in less than one month. With the tagline, 'Designed for Future', NanoSTIX practice vibrant and energetic office culture with fun balanced working environment. In 2022, we will launch new product called NanoSTIX Neo, with bigger capacity, better battery lasting and more powerful. Don't miss you chance to grab it once we launch it.
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Article Contents ::
- 1 The Brand Name PENTISAN Has Generic Salt :: Pantoprazole
- 2 PENTISAN Is From Company SANCHEZ LAB. Priced :: Rs. N.I.
- 3 PENTISAN have Pantoprazole is comes under Sub class GERD, of Main Class Gastrointestinal System
- 4 Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: GERD,
- 5 Disclaimer ::
- 6 The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.
The Brand Name PENTISAN Has Generic Salt :: Pantoprazole
PENTISAN Is From Company SANCHEZ LAB. Priced :: Rs. N.I.
PENTISAN have Pantoprazole is comes under Sub class GERD, of Main Class Gastrointestinal System
Main Medicine Class:: Gastrointestinal System Sub Medicine Class :: GERD,
Salt Name : OR Generic Name | Form | Price : MRP /Probable | Packing | ||
Pantoprazole | INJ | Rs. N.I. | VIAL |
Brand Name | Company / Manufacturers | Strength | Unit | Price / VIAL |
PENTISAN | SANCHEZ LAB. | 40MG | VIAL | Rs. N.I. |
Company Brand Name | Salt Combination | Main Medical Class | Sub Medical Class |
From SANCHEZ LAB. :: PENTISAN | Pantoprazole | Gastrointestinal System | GERD, |
Indications for Drugs ::
Peptic ulcer disease, H. pylori infection, Gastro-oesophageal reflux disease, Zollinger-Ellison syndrome, Oesophagitis, Acid-related dyspepsia, NSAID-associated ulceration, ulcer resistant to H2 receptor antagonists, Gastrointestinal (GI) bleeding from stress, Prophylaxis for acid aspiration syndrome during induction of anaesthesia
Drug Dose ::
Adult: PO The usual recommended adult oral dose is 40 mg given once daily, before breakfast. The duration of therapy is ranging from 2-8 weeks. Peptic ulcer: 40 mg/day in the morning. Duration: Duodenal ulceration: 2-4 wk; Benign gastric ulceration: 4-8 wk. GERD: 40 mg tablet, once daily in the morning for 4 to 8 weeks. In resistant ulcers: 40 mg tablet, once daily for 8 weeks. Ulcers induced by NSAIDs: 40 mg tablet once daily, in patients receiving continuous treatment with NSAIDs. GI bleeding from stress or acid peptic diseases: Usual adult oral dosage, if required the dosage may be increased. H. pylori infection: 40 mg twice daily w/ clarithromycin and either amoxicillin or metronidazole. Zollinger-Ellison syndrome: 160 mg tablets per day. Once control of acid secretion has been achieved, the dose should be gradually reduced. Prophylaxis for acid aspiration syndrome during induction of anaesthesia: 40-80 mg tablet should be given the evening before surgery and repeated again the morning of surgery. IV Zollinger-Ellison syndrome and other hypersecretory states As Na salt: 80 mg/day. Max: 240 mg/day in divided doses if rapid control required. GERD; Peptic ulcer As Na salt: 40 mg/day until PO can be resumed. Maintenance therapy Maintenance treatment should involve the lowest dose of the drug. Both 20 and 40 mg doses of Pantoprazole are safe and effective in maintaining patients with healed reflux esophagitis and PUD in remission. Elder patient: No problems with Pantoprazole have been encountered in clinical use in this patient group.
Contraindication ::
Lactation. Delayed release tablets are contraindicated in patients with known hypersensitivity to any of the formulation.
Drug Precautions ::
Long-term therapy may lead to bacterial overgrowth in the GI tract. Hepatic impairment; monitor liver function regularly (if enzymes increase, discontinue); pregnancy; not recommended in children <18 yr; long term use may lead to atrophic gastritis. Patients should be cautioned that Pantonix delayed release tablets should not be split, chewed or crushed. Drug Side Effects ::
Diarrhoea, dizziness, pruritus, skin rashes, GI tract infections, chest pain, headache, nausea, pain, anxiety, hyperglycaemia; malaise or lassitude; myalgia; oedema; insomnia; hyperlipidaemia; flatulence, abdominal pain, constipation, eructation, dyspepsia, rectal disorder; urinary frequency, UTI; abnormalities in liver function; local site reaction; hypertonia, neck pain, weakness; bronchitis, cough, dyspnoea, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, flu syndrome.
Pregnancy category ::
Drug Mode of Action ::
Pantoprazole is a substituted benzimidazole, and also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.
Drug Interactions ::
Ketoconazole; phenprocoumon, warfarin; atazanavir. Concomitant use of proton pump inhibitors w/ methotrexate may elevate & prolong serum levels of methotrexate &/or its metabolite, possibly leading to methotrexate toxicities.


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October 1957
In 1539 the former mayor of the town of Northampton, England, a prosperous wool merchant named Lawrence Washington (the great-great-great-greatgreat-grandfather of George Washington) settled north of Oxford in the hill country known as the Cotswolds. There he built a handsome stone cottage for himself and his large family which he called Sulgrave Manor.
In 1539 the former mayor of the town of Northampton, England, a prosperous wool merchant named Lawrence Washington (the great-great-great-greatgreat-grandfather of George Washington) settled north of Oxford in the hill country known as the Cotswolds. There he built a handsome stone cottage for himself and his large family which he called Sulgrave Manor. Part of a monastic estate confiscated by King Henry VIII when he broke with the Church of Rome five years earlier, it was situated in pleasant farm country where ancient lanes wandered for miles between wild rose hedges (which sometimes concealed highwaymen), and certain lonely barrows were reputed to be gathering places for local witches. This was a region where Nonconformist sects gained an early foothold, and the Puritanic tendencies of the natives were proverbial.
The two panels of heraldic stained glass which adorn the front and back covers of this issue were originally at Sulgrave Manor. This spring they were sold by their owner, British author Sacheverell Sitwell, to the Corning Museum of Glass in Corning, New York, where they are now on permanent display. Of seven related panels, these are the only ones which have come to George Washington's native country.
Both panels shown here were probably made in 1588, the year Queen Elizabeth's Navy and the storms which Spaniards called "Protestant winds" destroyed the great Armada. The panels commemorate two marriages in the Washington family, one of them bearing the coat of arms of John Washington and Margaret Kytson, and the other, the arms of Margaret Butler and a second Lawrence Washington, the grandson of the builder of Sulgrave Manor.
The Washington coat of arms has a pattern of red and white bars and three five-pointed stars—or, in more heraldic language, "Argent, Two Bars Gules, in Chief Three Mullets of the Second." Some historians have made the perhaps romantic assertion that these Washington arms were the original inspiration for the national flag of the United States which the Continental Congress adopted on June 14, 1777.
Apparently the Washington family fortune diminished in the years after the panels were made, for in 1610 Sulgrave Manor had to be sold. Almost fifty years later the first Washington arrived in the New World. In 1657—the last year of Oliver Cromwell's Puritan dictatorship in England—George Washington's greatgrandfather John sailed to Virginia as first mate and part owner of a trading ketch. When his ship was wrecked on a Rappahannock River shoal, John Washington elected to remain in America. The prospect of plentiful tobacco land was inviting; and, too, he must have been happy to settle beyond the stern reach of a Puritan-dominated England. For John Washington had seen his clergyman father ruined by the Puritans, who had branded him as a "common frequenter of ale houses" and ousted him from his parish.
As the Washington name became famous, Sulgrave Manor fell upon hard times. One wing was demolished in the eighteenth century; and when Washington Irving visited early in the 1850'$, he could report that "A part only of the manor house remained and was inhabited by a farmer." While at Sulgrave, Irving also viewed some of the heraldic panels. "The Washington crest, in colored glass, was to be seen in a window of what was now the buttery," he wrote. "A window on which the whole family arms was emblazoned had been removed to the residence of the actual proprietor of the manor."
The latter were evidently the same panels which came into the hands of the Sitwell family when it purchased Sulgrave Manor at this time. Recently, Sacheverell Sitwell related that when his great-grandfather bought the house, he seemed to have some inkling of the potential historical value of the panels, for he had them removed from their place in the hall and enclosed in a wooden box.
This year two of the Washington panels were brought to America. Five more originals remain in England, and facsimiles of all seven may be seen in Sulgrave Manor, which was purchased in 1914 by the British Committee for the Celebration of 100 Years of Peace between Britain and America and restored to its original condition.


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The Well Hung Gun
Cari Silverwood
A kinky western spoof featuring John Beastwood, a hero with six guns and six tentacles.
While in search of a man-flu cure, Virginia trips on a nuclear powered skateboard and goes back in time to 1860. She marches into Peckerwood Springs determined to find her way back to her future.
If any damn were-squid gunslinger gets in her way, Virginia's gonna shove his nearest tentacle up his own whatsit.
Back to the future on acid, with a hefty dose of sex and tentacles.
Cari Silverwood is a New York Times and USA Today bestselling author of BDSM stories and dark erotic fiction.
She writes the way the world should be – dangerous and sexy with bullets piercing the darkness and lovers wrenched close by ropes. When you need escape, when you need that rough lover to bring you to your knees, here you will find stories to singe your fingers. The taste of adventure, the tang of BDSM, the burn of fantasy run wild. Brace yourselves, if you dare to read.
And…in this real world, she has a lovely family in Australia, with the prerequisite teenager who dwells in the dark bedroom catacombs…a husband who raises eyebrows when he catches glimpses of what she writes, and a menagerie of other animals barking, meowing, and swimming about the place.
Website: www.carisilverwood.net
Twiiter: https://twitter.com/CariSilverwood
Previous book in the
of the Squirm Files series:
Book #1 Squirm - http://goo.gl/1sXVnJ
Book #2 Strum - http://goo.gl/Du4pjQ
Also releasing by Cari Silverwood
Amazon: http://goo.gl/zTBYLI


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Cobie Smulders – Babe Of The Day [VIDEO]
Sure, everybody's walking out of 'The Avengers' talking about Scarly Jo in her leather Black Widow catsuit, but let's give a little love to Cobie Smulders, aka S.H.I.E.L.D. agent Maria Hill. She may not have the leather, but she is just as hot, and now also a Rock 102.9 Babe of the Day!
Born in Vancouver, BC, Jacoba Smulders ("Cobie" is a nickname, in case you were wondering) originally wanted to be a doctor or a marine biologist. In high school, she discovered two things: one, she had a talent for acting, and two, she was smoking hot. In her teens, she was scouted by a modeling agency and started appearing in a variety of print pieces. She actually didn't enjoy modeling all that much, just using it as a bridge to acting professionally.
Her first gig was on the Showtime series 'Jeremiah,' but she went on to a recurring role on 'The L Word' before landing the part of Robin on 'How I Met Your Mother.' Unfortunately for all of us crushers, she's married to 'Saturday Night Live' cast member Taran Killam.


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About Our Service
For many vehicle owners, renewing a vehicle registration online through the state portal is quicker and easier than doing so in person, but it is still a manual process that needs to be remembered, completed and then repeated on an annual basis. Even though online registrations have improved the customer experience versus visiting the DMV in person, there are still many ways that the process could be improved to be more convenient and less stressful, especially for those looking for a more tailored and customer-focused experience.
That's where we come in.
By offering One-Click Renewals, we make sure that you only have to submit your vehicle information one time, and then we handle the process from there. In addition, we handle those rare but frustrating complications that can arise with the state, without any need for you to get involved. We offer convenient payment options (such as PayPal and Apple Pay), we monitor your renewal to make sure that it has been processed with the state in a timely manner, and make follow up calls if there seems to be an issue. We offer status checks so that you can know exactly when to expect your sticker, without ever having to pick up the phone and wait on hold with a government office. We process your transaction through the state system on your behalf, so your payment information is never processed or stored on a government server. Our site is rarely down for maintenance, so you can always renew even during those frequent times when the state site isn't available, and we offer night/weekend customer service so that you always have somebody you get in touch with if you have a question. We also check for errors in your submission, making sure that there should be no issues when your renewal is sent to the state for processing. In some states, we even make a donation on your behalf to support local funds for every transaction processed on our site. And to top it all off, we also offer a customer satisfaction guarantee for any customer that is not satisfied with our service.
So are you ready to join us in a better way to renew online? We are proud of what we do to enhance the state's online registration process, and always welcome feedback on how we can make things even better for our customers.
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Burgtec Shimano Crank Bolt for Hollowtech II Cranks & Shimano E-Bike Motors
This item is currently not available.
Pre-tension Bolt for Shimano Hollowtech II Cranks and Shimano E-bike motors.
Simplify things with an 8mm fitting and add a splash of your favourite anodised color. Never worry about turning the garage upside down at midnight to find that little 'thingy' to pre tension your cranks ever again.
- Remember this product needs minimal torque and do not exceed the manufacturers maximum recommended torque 0.7 to 1.5Nm
- Suits: XTR, XT, SLX, LX, Deore, Saint & Zee cranks and bikes with a Shimano e-bike motor.


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STONY BROOK, N.Y. (AP) — Among the procedures Army surgeon Hawkeye Pierce performed on "M.A.S.H." was an end-to-end anastomosis.
Most of the viewers, actor Alan Alda concedes, had no idea he was talking about removing a damaged piece of intestine and reconnecting the healthy pieces.
Today, the award-winning film and television star is on a mission to teach physicians, physicists and scientists of all types to ditch the jargon and get their points across in clear, simple language.
The former host of the long-running PBS series "Scientific American Frontiers" is a founder and visiting professor of journalism at the Stony Brook University Center for Communicating Science, which has just been named in his honor.
"There's no reason for the jargon when you're trying to communicate the essence of the science to the public because you're talking what amounts to gibberish to them," Alda said in a recent interview with The Associated Press.
A better understanding of science, Alda said, can benefit society in ways great and small. Physicians can more clearly explain treatments to patients. Consumers can decipher what chemicals may be in their food. And lawmakers can make better decisions on funding scientific research.
"They're not going to ask the right questions if science doesn't explain to them what's going on in the most honest and objective way," said Alda, 77. "You can't blame them for not knowing the jargon — it's not their job. Why would anybody put up money for something they don't understand?"
Alda, who lives in New York City and has a home on eastern Long Island, said that as his 12-year tenure as host of "Scientific American Frontiers" was ending in 2005, he began seeking out a university interested in his idea for a center for communicating science. He described himself as a "Johnny Appleseed" going from university to university shopping his idea.
Stony Brook, a 24,000-student state university about 70 miles east of Manhattan, "was the only place that understood what I was trying to say and thought it was possible," he said.
The center launched in 2009. At a gala last week, the Long Island school officially renamed it the Alan Alda Center for Communicating Science.
"Alan did not casually lend his celebrity to this effort," said Stony Brook President Dr. Samuel Stanley. "He has been a tireless and full partner in the center since its inception. During the past four years, he has traveled thousands of miles championing its activities. ... He has helped train our faculty and develop our curriculum, and he personally teaches some workshops."
Alda has also helped publicize a contest the center sponsored the past two years asking students and scientists around the country to find simple ways to explain such concepts as "What is a flame?" or "What is time?"
Among the courses taught by the center is an improvisational acting class that teaches scientists ways of communicating their thoughts clearly to others.
"We've learned it's important to set up vivid analogies," said Lyle Tomlinson, a 24-year-old neuroscience graduate student from Brooklyn who's working as a teaching assistant, noting he used the effects of caffeine in a morning cup of coffee to begin a discussion on the nervous system.
Rep. Steven Israel, whose district includes the Stony Brook campus, said educating people on the importance of science is key to America's competitiveness in the 21st century economy.
He recalled watching a congressional hearing on climate change in which, he said, "a bunch of scientists were trying to teach congressmen about the science of climate change and the congressmen were trying to teach the scientists about politics. It was as if both sides were speaking alien languages."
Alda shared what he called his best examples of clear communication with Tomlinson and his fellow teaching assistants.
About a decade ago, Alda said, he was in Chile filming a segment for "Scientific American Frontiers" when he was stricken with sharp stomach pains. He was evacuated from an 8,000-foot observatory and taken in an old rickety ambulance to a small, dimly lit clinic, where a doctor examined him and said he would require life-saving surgery.
"Some of your intestine has gone bad, and we have to cut out the bad part and sew the two good ends together," the physician explained.
"And I said, 'You're going to do an end-to-end anastamosis.' He said, 'How do you know that?' And I said, 'Oh I did many of them on 'M.A.S.H.' That was the first operation I learned about on M.A.S.H.'"
After the classroom erupted in laughter, Alda concluded:
"He didn't waste any time on me trying to figure what he was talking about. He said it in the clearest terms possible. He didn't sacrifice any accuracy by making it clear."


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Lead time:
Your wishlist has been temporarily saved. Please Log in to save it permanently.
We offer free shipping and returns on orders $50+ within the continental US. If expedited shipping is required, please contact us directly at firstname.lastname@example.com or 781.262.5854. Orders over $1,000 will require a signature upon delivery.
Most orders should be delivered within 3-7 days.
Store pickup is available on in-stock items, Tuesday - Saturday. For full details, please visit our Shipping or Returns pages.
Long's ensures that all pre-owned timepieces are in good working order when sold and offers a two-year Limited Warranty at time of sale, subject to certain restrictions described below. In the event, that a modern pre-owned timepiece malfunctions during normal use, Long's will be responsible for, and liability will be limited to, repairing or replacing damaged parts so that the timepiece is in good working order. All work and manner of work will be at Long's discretion and the two-year warranty period is not extended if Long's repairs or replaces the merchandise. The Limited Warranty does not cover damage due to water, shock, abuse, modifications, misuse or normal wear and tear. Any modifications of any kind, tampering or opening of the watch to expose the movement post-sale will void the Limited Warranty.
For vintage watches (currently noted as 1985 or older), Long's provides a 30-day Vintage Limited Warranty that expects reasonable and careful treatment by the purchaser. Each watch will be in working condition at time of sale, though no confirmation of specific accuracy level or waterproofing can be provided. The distinction between vintage and other watches is due to parts not being as readily available and typically cannot be repaired. Long's reserves the right to offer certain vintage watches and pocket watches with no warranty coverage, which will be communicated to the customer prior to and at time of sale in "as is" condition.
Voted "Boston's Best" Jeweler, our reputation spans over 140 years throughout New England and beyond.
Our in-house jewelers address the condition of each piece, assuring your jewelry arrives clean, with secure settings, and ready to wear.
Every estate piece is fully inspected by our jewelry authenticators, allowing you peace of mind to purchase.
We want you to love your purchase, so we offer easy returns and exchanges!
I'm very happy with my purchase. I really like the feature on your site that lets me try rings on virtually; it was really helpful. I would definitely shop with Long's again.
- Alex. A
When the ring arrived, it was actually BETTER than the picture. I will definitely buy from them again.
- Greg J.
There is a wide selection, and the prices are really affordable for classic, one-of-a-kind pieces.
- Marie R.
This is the second time we have bought online from Long's. They carry more quality vintage or previously owned items that you can't find elsewhere. I especially like knowing that I am buying from a reputable dealer. And their shipping is very fast and very well packed.
- Kim S.
Not only is the quality of the jewelry excellent, but the helpfulness and knowledge of the staff is superb.
- Wendy L.


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9blox.com creates a simple web page. Everyone who knows its link can read and (if allowed) edit it.
9blox.com creates a simple web page. Everyone who knows its link can read and (if allowed) edit it.
Site created and operated by Frank Dux, Flemingweg 59, D-40591 Düsseldorf, phone: +49 (0) 171 2309614, E-Mail: email@example.com
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@jasonstathamtiktok #jasonstatham #fastandfurious #fypシ
♬ See You Again (feat. Charlie Puth) - Wiz Khalifa
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WD, a Western Digital company and a worldwide leader in storage solutions, and Milestone Systems, the security industry leader in video management software, announced today a partnership to deliver video surveillance solutions to businesses and consumers.
Milestone Arcus Surveillance software will be available on WD's My Cloud Business Series network-attached storage (NAS) systems beginning this month; and is expected to be available on other My Cloud systems, such as the My Cloud Expert Series, in the future.
Milestone Arcus is a video surveillance platform designed to be embedded in hardware devices, such as compatible WD My Cloud NAS systems, to deliver customized, market-ready solutions. Integration of Milestone Arcus Surveillance software into My Cloud OS enables users to transform their versatile My Cloud Business Series NAS systems into networked video recording systems for their offices or homes. By simply downloading the Milestone Arcus Surveillance software through the My Cloud App Store, users can install up to 16 cameras, with the first two camera licenses free on My Cloud Business Series products. Additional camera licenses will be available at selected WD authorized distributors.
"Technology advances are enabling video surveillance to be broadly accessible to businesses and individuals across the globe," said Sven Rathjen, vice president of marketing for WD's Content Solutions business. "Together, WD and Milestone are focused on making video surveillance easy with a solution they can quickly set up and rely on for years. This is one of many applications available on My Cloud NAS systems, including home automation, media streaming and backup solutions."
"Milestone is proud to partner with WD to offer a video surveillance solution for My Cloud NAS systems," said Lars Nordenlund, vice president of Incubation and Ventures at Milestone Systems. "WD customers can now take advantage of the simple setup with automatic camera discovery, intuitive interface, remote viewing, mobile access and other monitoring features in Milestone Arcus software."
WD's My Cloud Business Series NAS systems are available through select distribution partners and resellers in Philippines.


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CORAL GABLES, Fl (June 18, 2010) — A University of Miami (UM) researcher will be presenting his work on Robotics and Artificial Intelligence (AI) at the 14th annual RoboCup World Championship and Symposium, an international robotic event whose goal is to advance AI and intelligent robotics research. Ubbo Visser, research associate professor of computer science at UM College of Arts and Sciences and team leader for the UM robotics team RoboCanes, will describe the architecture of the multiagent system (MAS) and discuss motion capture techniques for graphical animation. Visser will share his findings in a paper titled: "TopLeague & Bundesliga Manager: New generation online soccer games" and participate in the 3D simulation soccer league with the RoboCanes, designed by the AI & Games group at UM. The event will take place in Singapore, June 19-25.
"The idea of using soccer as a test bed for robots is to learn about the needs of agents, or robots that act in real-time, dynamic, and adversarial environments," says Visser. "To understand what it takes for a robot to integrate knowledge and put information into context so that it can make decisions in a split second: that is one of the hardest problems in AI and robotics to solve right now."
RoboCup (originally called The Robot World Cup Soccer Games and Conferences) started in 1997, and over the years has become the prevalent robotics competition in the world. The primary focus of the event is soccer games; it involves more than 3,000 researchers, about 450 teams and participants from over 40 countries.
For the event, the contestants develop autonomous robots and software agents and take part in games, simulations, conferences, and educational programs, but RoboCup is not just about playing games, explains Visser, who is one of the Trustees of the RoboCup Federation.
"There is a noble goal behind this work, namely to understand what's going on if we send robots in the field and let them do the work of humans," says Visser. "Doing this work gives one a lot of respect for the human mind; people can have this huge amount of experience of what to do in unforeseen situations and that is exactly what we are trying to solve with robots: what techniques are successful in these sorts of situations is what we are touching on."
The University of Miami team the RoboCanes is one of only two US teams participating in the 3D simulation soccer league. Like the real World Cup in soccer, in RoboCup a team has to qualify to participate. One way to qualify is to win a regional open; another is fulfilling guidelines and qualification rules. The games are divided into the following leagues: Simulation League — 2D and 3D; Small Size Robot League, Middle Size Robot League, Four-Legged Robot League, and the Humanoid League.
This is the first time UM participates in this event. To take part in this competition, the AI & Games Group had to develop a soccer team of six 3D robots, meaning they have a complete resemblance to a physical robot. The robots are autonomous and have the ability to acquire strategic knowledge and real-time reasoning and can communicate and cooperate with each other during a game.
Knowing how difficult it is to win this event, the team is setting their sights to making it through its first round. "The idea is to develop our team and to be successful; this means to pass the first round this year," Visser says. "If we manage that, it will be a great success, but we would like to evolve into the real robot league, next year."
The other US team participating in the 3D simulation soccer league is from the University of Texas at Austin. In addition to the RoboCupSoccer, the event has three other areas: RoboCupRescue, RoboCup@Home and RoboCupJunior.
To observe a video clip of RoboCanes in action, go to: http://www.cs.miami.edu/aigames
About the University of Miami
The University of Miami's mission is to educate and nurture students, to create knowledge, and to provide service to our community and beyond. Committed to excellence and proud of the diversity of our University family, we strive to develop future leaders of our nation and the world. www.miami.edu


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Some malls and airports can be just as tricky to navigate as a city you don't know. Google Maps for Android now has help, in the form of indoor maps that locate you within a few meters, whatever floor you're on, and show you the shops, facilities, and other things you're looking for.
You don't need to do anything to bring up the indoor map, other than make sure your Android is running the latest Maps version (6.0 at the moment). When you're in an indoor location mapped out by Maps, zooming in on your location brings up a detailed map of your surroundings, with points like restrooms, stores, and luggage carousels pointed out and easy to tap for information. Google says that it can follow you up and down escalators and elevators, but then again, GPS signal location inside large concrete structures can be if-y.
If you end up at a spot with indoor Maps support, let us know how it worked for you in the comments.
A new frontier for Google Maps: mapping the indoors | Google LatLong Blog
You can reach Kevin Purdy, the author of this post, on Twitter at @kevinpurdy or on Google+.


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Chicago River: 1.5-Hour Guided Architecture Cruise
Experience more of Chicago by boat than on any other architectural cruise. See architectural highlights and enjoy an open-air deck or climate-controlled interior as you travel the main River and its north and south branches. View all of Chicago's architectural highlights during this comprehensive sightseeing tour. Be entertained by the expert and friendly tour guides as they explain the 130 year-long history behind the skyline, while bartenders and staff keep you comfortable with refreshments. Choose between the fresh air of the open-air decks or enjoy the comfort of the climate-controlled interiors during your cruise. The tour starts at the Michigan Avenue (DuSable) bridge and goes up the main branch of the Chicago River past Wolf Point. It then cruises along the north and south branches of the river, before heading back past the Chicago Riverwalk towards Lake Michigan. On the way, learn about ornate, historic early skyscrapers like the Wrigley Building and the Tribune Tower, the imposing art deco Merchandise Mart, mid-century skyscrapers like the Mies Van der Rohe AMA Building. Don't miss the circular Marina City Towers, the majestic Willis Tower (formerly the Sears Tower and the tallest building in Chicago) the soaring AON Center, and more modernist structures like Aqua, Trump Tower, Nuveen, and the new Vista Tower. During your cruise, have the opportunity to enjoy a full-service cash bar featuring authentic Chicago products, including local beer and spirits, and Garrett's Popcorn. Don't forget to take a selfie at the Grand Staircase at the front of the boat or pose for photos at the picturesque stern or bow of this classic vessel.


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Calera Mt. Harlan Gift Set
Rich in limestone and reaching soaring elevations of 2,200 feet, Mt. Harlan has become legendary among collectors for yielding wines of incomparable grace and purity. Bringing together the radiance of Calera's Mt. Harlan Chardonnay and the grandeur of the iconic Jensen Vineyard Pinot Noir, this is the gift they'll want to open last! Presented in beautiful packaging and ready to share.
This gift contains each of these items:
Important Shipping Information
Wine gifts do require an adult signature upon delivery by an adult 21 years of age or older. We strongly recommend shipping to a business address whenever possible.
Standard Bottle
5 - 5oz Glasses
Serves 2-4
1.5 Liters
2 Standard Bottles
Serves 4-5
Double Magnum or Jeroboam
3 Liters
4 Standard Bottles
Serves 6-8
6 Liters
8 Standard Bottles
Serves 12-16


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We are talking about #WonderFilledBubbles by Cadbury today. Every now and then, we discover something new or learn something about someone that we never expected, something fun or surprising that
Ossify Media is the home for all entertainment lovers. Here you can catch up on African News, Celebrity Entertainment and Trends.


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38 ABS Information about the labour market can be found on the Topics @ a Glance page on the ABS website <https://www.abs.gov.au>. 39 Information about current publications and other products released by the ABS is available from the statistics page on the ABS website. The ABS also issues a daily release advice on the website, Upcoming Product Releases, which details products to be released in the week ahead. DATA AVAILABLE ON REQUEST 40 As well as the statistics included in this and related publications, the ABS may have other relevant data available. Inquiries should be made to the Labour Force contact officer on (02) 6252 6525, email firstname.lastname@example.com or to any ABS office. EFFECTS OF ROUNDING 41 Estimates have been rounded and discrepancies may occur between sums of the component items and totals. Estimates of movement shown in this publication are obtained by taking the difference of unrounded estimates. The movement estimate is then rounded. Where a discrepancy occurs between the reported movement and the difference of the rounded estimates, the reported movement will be more accurate. SYMBOLS AND ABBREVIATIONS 42 SYMBOLS AND ABBREVIATIONS
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Strawberries & Cream. Two amazing fragrances even better together. Berries & cream. Yum! This is the sweetest strawberry mingled with warm creamy sweet vanilla. Colored medium pink.
MEGA Nuggets™ are exactly the same as my other Nuggets™ but a lot larger in size. Perfect for those bigger melters, and definitely a more cost effective way to purchase! 5oz size means about 70 hours of scenting time! This size is currently poured to your order. This purchase will be for the quantity you request, in this fragrance, in the MEGA size! Check out the photos to see a comparison of the MEGA size to my Classic melts, as well as some finished products.
Wax melts (tarts) are a great way to add fragrance without burning or soot. And a great solution to bring scent to places where burning a candle isn't desirable or feasible. Simple melt in a UL approved melter and in a safe place out of reach of curious fingers or paws. Wax is very hot but cools rapidly when removed from heat (if you've ever had a paraffin manicure you know what I mean).
More than 100 scents are available, some seasonal.
Nuggets™ are also great mixers. Create your own special blend by putting a chunk of this or that into the melting vessel. That's something you can't do with a candle! Depending on the wattage of your melter (higher wattage are warmer and thus will shorten the scent time, but they get wax melted much faster), your Nuggets™ package should provide from 30-35 hours of fragrance.
Finally, hot wax does cool fast, but it also makes for a 'not so fun' cleanup so please ensure that your melter is placed in a 'non wobbly' area. I personally put mine on my kitchen countertop away from my normal food prep area. The stone counters are impervious to heat and if spills occur (never has so far!) would be easy to clean.
The compare photo shows my Classic 2oz compared to the Mega 5oz package. Each one is ordered separately. While the Classic size are normally in stock, I do pour every order for the Mega size to order.


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Cloud Chandelier by Jordy Fu
Yu Jordy Fu had her first solo exhibition at Beijing Capital Museum at age of six, she graduated from Central Saint Martins College of Art and Design with a first-class degree in Spatial Design, and then received a Master of Arts in Architecture and Interiors from the prestigious Royal College of Art. Jordy has exhibited at some of the most influential exhibitions in the world of art and design, such as the Venice Biennial, Milan International Furniture Fair, 100% Design London. She is the commission artist for Royal Festival Hall London and commission designer at Design Museum London. Jordy's works have been published into six design books and over fourty high-end design and architecture magazines in 19 countries. In 2010, Jordy is exhibited at the London Fashion week, the British Design Awards then Hong Kong Arts Center. | ||||||||||||||||||||||||||||||


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Marvel Heroes 2015 occurring on June 4th, the first anniversary of Marvel Heroes. Along with the anniversary, Marvel Heroes 2015 will be launching its Open Beta on Mac.
The culmination of a year's worth of game content, Marvel Heroes 2015 marks a significant step forward for the Marvel Heroes franchise and includes sweeping improvement made over the original launch. New features and a number of new game modes have also been added alongside the ever-expanding superhero roster. For the anniversary, players can look forward to new end-game raid content that will have them face off against the ruler of fire demons himself, Surtur.
Click here to view the teaser trailer: http://youtu.be/YQJ0JcsfVbQ
"Marvel Heroes 2015 nicely represents everything we have accomplished and intend to accomplish with one name," said David Brevik, CEO, Gazillion. "We've come a very long way since our original launch a year ago, and the now imminent release of Marvel Heroes 2015 alongside our massive anniversary celebrations marks the beginning of something even better. Whether it's defending the X-Mansion or recruiting your favorite superhero as a Team-Up, we're excited to continue delivering on our community's expectations. We truly believe we put more improvements into our game than any other iterative release out there. The 2015 moniker reaffirms our commitment to keep doing it."
What is Marvel Heroes 2015?
Marvel Heroes 2015 is a new launch for the Marvel Heroes brand coinciding with a one-year anniversary milestone on June 4th and it highlights all the new game content added since launch. Marvel Heroes 2015 also includes even more game content, including end-game raids, alternate advancement systems and other various additions. For Gazillion, it's a new release and a challenge to continue adding more content and improvements than any other iterative release on Earth.


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What to Really Expect From the Government Shutdown
by Ron Paul
It's deja-vu all over again, as baseball legend Yogi Berra might have said. The politicians and media are telling us the world is coming to an end because a "compromise" could not be made at the 11th hour to keep the Federal government in business.
Republicans blame Democrats for the shutdown over their insistence on legislation to benefit about 700,000 "Dreamers" — immigrants who were brought illegally in to the country as children. Democrats make the shutdown all about Donald Trump, hoping to gain political points from his unpopular status. The media headlines are recycled from the last phony "shutdown." It's all about "partisanship" in Washington, mainstream media tells us. The same pundits are on television demanding that the parties put aside differences and work together for the American people.
Don't let the politicians and the media fool you. Despite the appearance of ferocious partisan warfare, the truth is that both political parties agree on all the important issues.
Both parties support perpetual, undeclared war.
Both parties voted last week to continue suspending the Fourth Amendment, granting President Trump and his Administration the "authority" to continue spying on all of us without a warrant for another six years. So much for Democrat talk that President Trump could not be trusted: they have entrusted him with the authority to spy on us for six more years!
Both sides agree on no spending limits for the warfare-welfare state. Both parties agree that the Federal Reserve should continue to manipulate our currency to the benefit of big banks, well-connected corporations, and Wall Street.
While they want to frighten us by claiming the shutdown will shut down the US military, making us less safe, the fact is Pentagon operations overseas will continue without pause. Defense Secretary Mattis assured us over the weekend that "daily operations around the world – ships and submarines will remain at sea, our aircraft will continue to fly and our war fighters will continue to pursue terrorists throughout the Middle East, Africa and South Asia."
In other words the Pentagon will function as if there was no Legislative Branch to rein them in. But that;s not new. That's been true for a long time!
Americans should understand that much of the Federal government is on auto-pilot. The deep state holds the cards no matter who is elected or how long the government is shut down. The CIA will continue arming terrorists and plotting to overthrow governments overseas. The "Justice" Department will continue handing out long prison sentences for people using marijuana even in states that have legalized marijuana. The NSA will continue spying on us without a warrant and telling us it is to keep us safe and free.
We are told that all "non-essential" personnel will be furloughed until Congress agrees to begin funding the Federal government again. In fact, the real "non-essential" personnel are most Members of Congress themselves! Perhaps their pay should be docked for each day they pretend to be in conflict. The only danger of that, of course, is that they would reach the inevitable compromise even sooner.
The only way average Americans will notice that the government is shut down will be high-profile closures of any national park or other such facility that Americans actually want to visit. That is their way of punishing Americans.
Who wins when a "compromise" is finally announced? Not the American people, that's for sure! The winner will be, as usual, big government.
TLB republished this article from Ron Paul with permission and our thanks to Dr. Paul for making it available. We recommend other pertinent article from Ron Paul and The Ron Paul Institute for Peace and Prosperity.


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A company that empowers service workers and helps them become entrepreneurial is planning to replace its app with a new Blockchain-based platform, helping providers with hard-earned reputations to win more business.
Crafty is initially going to launch in Brazil but believes its marketplace can transform the "extremely inefficient" service sector worldwide by ensuring a higher proportion of revenue goes to self-employed workers on the front line.
"Decent working conditions anywhere"
The founders of Crafty have already tested their concept through an app called Diaríssima, which launched in 2016. The company has described this as a minimum viable product (MVP), as it focused solely on connecting household cleaners with paying customers.
After opening for business in São Paulo, Diaríssima expanded nationwide and now boasts tens of thousands of customers and service providers, the company states.
Crafty, Diaríssima's replacement, is to increase the number of services on offer considerably, and opportunities listed in its white paper include cooks, tutors, nannies, caregivers, gardeners and drivers. Underpinning all of this will be a Blockchain-based system where trust is established with every interaction between customers and providers.
This allows self-employed workers, who will use the platform for free without incurring any intermediary fees, to benefit from their reputation. In time, Crafty is planning to use artificial intelligence (AI) to offer "meaningful recommendations" to prospective customers who are searching for service providers.
Crafty is hoping to tackle five of the 17 Sustainable Development Goals established by the United Nations, one of which is "ending poverty in all its forms." The company believes its lack of fees will result in higher frequencies of use, create a more level playing field where prices are more difficult to dictate and result in "decent working conditions everywhere."
First Brazil, then the world
There are a few hurdles Crafty is determined to tackle. Among them is the fact that, on the face of it, a platform using cryptocurrency seems to be an unusual choice in a country where 40 percent of the adult population do not have a bank account (according to research by Instituto Data Popular.) Here, virtual accounts including debit cards would enable Crafty users to receive money and spend it opening new opportunities to 55 mln Brazilians and making cryptocurrency available to people from all socioeconomic backgrounds.
The company says it wants to encourage use of Crafty (CFTY) tokens in local commerce by negotiating partnerships with business groups and it claims this would enable token holders to access prepaid credit for everyday items such as mobile phones and electronics.
Crafty's website and app have initially been written in Portuguese, but the company says its platform's design means translating into other languages is easy.
Once a 45-day ICO concludes on April 9, the company is planning a massive promotional drive to attract new users, and a large proportion of its funding is being earmarked for marketing. It is expected that a virtual wallet will be integrated into Crafty accounts by September 2018. Additional services that providers can offer are going to be added every few months, with the platform forecasting that 150 professions will be covered by March 2020.
The company is confident that its idea can improve the lives of service workers around the world and plans to expand internationally in the coming years. Eventually, it hopes imperfections in the market will be eliminated, helping incomes to rise and granting more people access to a healthy, comfortable and financially secure life.
Disclaimer. Cointelegraph does not endorse any content or product on this page. While we aim at providing you all important information that we could obtain, readers should do their own research before taking any actions related to the company and carry full responsibility for their decisions, nor this article can be considered as an investment advice.
Cointelegraph.com is author of this content, TheBitcoinNews.com is is not responsible for the content of external sites.
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In my new book Economics: The User's Guide, I aim to show the reader how to think, not what to think, about the economy. There are a few important things to keep in mind when you are 'using' economics.
Cui bono?
Economics is a political argument. It is not - and can never be - a science; there are no objective truths in economics that can be established independently of political, and frequently moral, judgments. Therefore, when faced with an economic argument, you must ask the age-old question 'Cui bono?' (Who benefits?), first made famous by the Roman statesman and orator Marcus Tullius Cicero.
Sometimes it is easy to see the political nature of an economic argument because it is based on questionable assumptions that blatantly favour certain groups. The trickle-down argument, for example, crucially depends on the assumption that, when given a bigger slice of national output, the rich will use it to increase investments - an assumption that has not been borne out by reality.
In other situations, an argument may favour certain people unintentionally. For example, the dominant Neoclassical school of economics uses the Pareto criterion to judge social improvement. It may seem not to favour anyone, as it says a change is a social improvement only when it makes some people better off without making anyone worse off and thus does not allow even a single person to be trampled on by the rest of society. Yet it implicitly favours those who benefit more from the status quo, as the criterion allows them to prevent any change to the status quo that hurts them.
Political and ethical judgments are present even in ostensibly value-free exercises, such as defining the boundaries of the market. Deciding what belongs in the domain of the market is an intensely political exercise. Once you can drag something (say, water) into the domain of the market, you can apply the 'one-dollar-one-vote' rule to decisions surrounding it, making it easier for the rich to influence the outcome.
Conversely, if you can take something (say, child labour) out of the domain of the market, it becomes impossible to influence its use with the power of money.
Saying that economics is a political argument does not mean that 'anything goes'. Some theories are better than others, depending on the situation at hand. But it does mean that you should never believe any economist who claims to offer 'scientific', value-free analysis.
Don't become a 'man with a hammer'
There isn't just one right way of 'doing' economics, despite what most economists tell you. Though the Neoclassical approach has been the dominant one in recent decades, there are at least nine different schools of economics, each with its strengths and weaknesses.
The economic reality is complex and cannot be fully analysed with just one theory. The various economic theories conceptualize basic economic units differently (e.g., individuals v. classes), focus on different things (e.g., macro-economy v. micro-economy), ask different questions (e.g., how to maximize the efficiency with which we use given resources v. how to increase our abilities to produce those resources in the long run) and try to answer them using different analytical tools (e.g., full rationality v. bounded rationality).
As the saying goes, 'he who has a hammer sees everything as a nail'. If you approach a problem from a particular theoretical point of view, you will end up asking only certain questions and answering them in particular ways. You might be lucky, and the problem you are facing might be a 'nail' for which your 'hammer' is the most appropriate tool. But, more often than not, you will need to have an array of tools available to you.
You are bound to have your favourite theory. There is nothing wrong with using one or two more than others - we all do. But please don't be a man (or a woman) with a hammer - still less someone unaware that there are other tools available. To extend the analogy, use a Swiss army knife instead, with different tools for different tasks.
The economy is much bigger than the market
Much of economics these days is about the market. Most economists today subscribe to the Neoclassical school, which sees the economy as a web of exchange relationships - individuals buy various things from many companies and sell their labour services to one of them, while companies buy and sell from many individuals and other companies.
But the economy should not be equated with the market. The market is only one of many different ways of organising the economy - indeed, it accounts for only a small part of the modern economy. Many economic activities are organised through internal directives within firms, while the government has influences - and even commands - over large sections of the economy. Governments - and increasingly international economic organisations like the WTO - also draw the boundaries of markets while setting rules of conduct in them. Herbert Simon, the founder of the Behaviouralist school, once estimated that only about 20% of economic activities in the US are organised through the market.
The focus on the market has made most economists neglect vast areas of our economic life, with significant negative consequences for our well-being. The neglect of production at the expense of exchange has made policy-makers in some countries overly complacent about the decline of their manufacturing industries. The view of individuals as consumers, rather than producers, has led to the neglect of issues like the quality of work (e.g., how interesting it is, how safe it is, how stressful it is, and even how oppressive it is) and work-life balance. The disregard of these aspects of economic life partly explains why most people in the rich countries don't feel more fulfilled despite consuming the greatest ever amounts of material goods and services.
The economy is much bigger than the market. We will not be able to build a good economy - nor a good society - unless we look at the vast expanse beyond the market.
This is an extract from Ha-Joon Chang's latest book, Economics: The User's Guide, which is available in stores now


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If you read or listen to almost any article about climate change, it's likely the story refers in some way to the "2 degrees Celsius limit." The story often mentions greatly increased risks if the climate exceeds 2°C and even "catastrophic" impacts to our world if we warm more than the target.
Recently a series of scientific papers have come out and stated that we have a 5 percent chance of limiting warming to 2°C, and only one chance in a hundred of keeping man-made global warming to 1.5°C, the aspirational goal of the 2015 Paris United Nations Framework Convention on Climate Change conference. Additionally, recent research shows that we may have already locked in 1.5°C of warming even if we magically reduced our carbon footprint to zero today.
And there's an additional wrinkle: What is the correct baseline we should use? The Intergovernmental Panel on Climate Change (IPCC) frequently references temperature increases relative to the second half of the 19th century, but the Paris Agreement states the temperature increases should be measured from "preindustrial" levels, or before 1850. Scientists have shown such a baseline effectively pushes us another 0.2°C closer to the upper limits.
That's a lot of numbers and data – so much that it could make even the most climate-literate head spin. How did the climate, and climate policy community, come to agree that 2°C is the safe limit? What does it mean? And if we can't meet that target, should we even try and limit climate change?
Fear of 'tipping points'
The academic literature, popular press and blog sites have all traced out the history of the 2°C limit. Its origin stems not from the climate science community, but from a Yale economist, William Nordhaus.
In his 1975 paper "Can We Control Carbon Dioxide?," Nordhaus, "thinks out loud" as to what a reasonable limit on CO2 might be. He believed it would be reasonable to keep climatic variations within the "normal range of climatic variation." He also asserted that science alone cannot set a limit; importantly, it must account for both society's values and available technologies. He concluded that a reasonable upper limit would be the temperature increase one would observe from a doubling of preindustrial CO2 levels, which he believed equated to a temperature increase of about 2°C.
Nordaus himself stressed how "deeply unsatisfactory" this thought process was. It's ironic that a back-of-the-envelope, rough guess ultimately became a cornerstone of international climate policy.
The climate science community subsequently attempted to quantify the impacts and recommend limits to climate change, as seen in the 1990 report issued by the Stockholm Environmental Institute. This report argued that limiting climate change to 1°C would be the safest option but recognized even then that 1°C was probably unrealistic, so 2°C would be the next best limit.
During the late 1990s and early 21st century, there was increasing concern that the climate system might encounter catastrophic and nonlinear changes, popularized by Malcolm Gladwell's "Tipping Points" book. For example, continued carbon emissions could lead to a shutdown of the large ocean circulation systems or massive permafrost melting.
This fear of abrupt climate change also drove the political acceptance of a defined temperature limit. The 2°C limit moved into the policy and political world when it was adopted by the European Union's Council of Ministers in 1996, the G8 in 2008 and the UN in 2010. In 2015 in Paris, negotiators adopted 2°C as the upper limit, with a desire to limit warming to 1.5°C.
This short history makes it clear that the goal evolved from the qualitative but reasonable desire to keep changes to the climate within certain bounds: namely, within what the world had experienced in the relatively recent geological past to avoid catastrophically disrupting both human civilization and natural ecosystems.
Climate scientists subsequently began supporting the idea of a limit of 1°C or 2°C starting over three decades ago. They showed the likely risks increase with temperatures over 1°C, and those risks grow substantially with additional warming.
And if we miss the target?
Perhaps the most powerful aspect about the 2°C threshold is not its scientific veracity, but its simplicity as an organizing principle.
The climate system is vast and has more dynamics, parameters and variations in space and time than is possible to quickly and simply convey. What the 2°C threshold lacks in nuance and depth, it more than makes up as a goal that is understandable, measurable and may still be achievable, although our actions will need to change quickly. Goals and goal-setting are very powerful instruments in effecting change.
While the 2°C threshold is a blunt instrument that has many faults, similar to attempting to judge a quarterback's value to his team solely by his rating, its ability to rally 195 countries to sign an agreement should not be discounted.
Ultimately, what should we do if we cannot make the 1.5°C or 2°C limit? The most current IPCC report shows the risks, parsed by continent, of a 2°C world, and how they are part of a continuum of risk extending from today's climate to a 4°C.
Most of these risks are assessed by the IPCC to increase in steady fashion. That is, for most aspects of climate impacts we do not "fall off a cliff" at 2°C, although considerable damage to coral reefs and even agriculture may increase significantly around this threshold.
Like any goal, the 2°C limit should be ambitious but achievable. However, if it is not met, we should do everything we can to meet a 2¼°C or 2.5°C goal.
These goals can be compared to the speed limits for trucks we see on a mountain descent. The speed limit (say 30 mph) will allow trucks of any type to descend with a safety margin to spare. We know that coming down the hill at 70 mph likely results in a crash at the bottom.
In between those two numbers? The risk increases – and that's where we are with climate change. If we can't come down the hill at 30 mph, let's try for 35 or 40 mph. Because we know that at 70 mph – or business as usual – we will have a very bad outcome, and nobody wants that.


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An anthology of 320 poems. Discover Chinese poetry in its golden age and some of the greatest Chinese poets. Tr. by Bynner (en).
Liu Zongyuan
Reading Buddhist Classics with Zhao
at his Temple in the Early Morning
I clean my teeth in water drawn from a cold well;
And while I brush my clothes, I purify my mind;
Then, slowly turning pages in the Tree-Leaf Book,
I recite, along the path to the eastern shelter.
...The world has forgotten the true fountain of this teaching
And people enslave themselves to miracles and fables.
Under the given words I want the essential meaning,
I look for the simplest way to sow and reap my nature.
Here in the quiet of the priest's templecourtyard,
Mosses add their climbing colour to the thick bamboo;
And now comes the sun, out of mist and fog,
And pines that seem to be new-bathed;
And everything is gone from me, speech goes, and reading,
Leaving the single unison.
Bynner 34
300 Tang poems – Tang Shi I. 1. (34) – Chinese off/on – Français/English
Alias Tang Shi San Bai Shou, Three Hundred Poems of the Tang Dynasty, Poésie des Thang.
The Book of Odes, The Analects, Great Learning, Doctrine of the Mean, Three-characters book, The Book of Changes, The Way and its Power, 300 Tang Poems, The Art of War, Thirty-Six Strategies
Welcome, help, notes, introduction, table.
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