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Major Study Proves Turmeric Kills Cancer
Virginia Commonwealth University finds that curcumin, found in turmeric, kills cancer.
In a laboratory, preclinical study recently published by the journal Organic & Biomolecular Chemistry, Virginia Commonwealth University Massey Cancer Center researchers combined structural features from anti-nausea drug thalidomide with common kitchen spice turmeric to create hybrid molecules that effectively kill multiple myeloma cells.
Thalidomide was first introduced in the 1950s as an anti-nausea medication to help control morning sickness, but was later taken off the shelves in 1962 because it was found to cause birth defects. In the late 1990's the drug was re-introduced as a stand-alone or combination treatment for multiple myeloma. Turmeric, an ancient spice grown in India and other tropical regions of Asia, has a long history of use in herbal remedies and has recently been studied as a means to prevent and treat cancer, arthritis and Alzheimer's disease. According to the American Cancer Society, laboratory studies have shown that curcumin, an active ingredient in turmeric, interferes with several important molecular pathways and inhibits the formation of cancer-causing enzymes in rodents.
"Although thalidomide disturbs the microenvironment of tumor cells in bone marrow, it disintegrates in the body. Curcumin, also active against cancers, is limited by its poor water solubility. But the combination of thalidomide and curcumin in the hybrid molecules enhances both the cytotoxicity and solubility," says the study's lead researcher Shijun Zhang, assistant professor in the Department of Medicinal Chemistry at the VCU School of Pharmacy.
Widget not in any sidebars
Compared to mixing multiple drugs, creating hybrid molecules can provide certain advantages. "Enhanced potency, reduced risk of developing drug resistance, improved pharmacokinetic properties, reduced cost and improved patient compliance are just a few of those advantages," says another of the study's researchers Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research, associate director for translational research, program co-leader of Developmental Therapeutics and Cancer Cell Signaling research member at VCU Massey Cancer Center.
The hybrid molecules of turmeric and thalidomide created more than 15 compounds, each with a different effect. Scientists found that compounds 5 and 7 exhibited superior cell toxicity compared to curcumin alone or the combination of curcumin and thalidomide. Furthermore, the compounds were found to induce significant multiple myeloma cell death.
"Overall, the combination of the spice and the drug was significantly more potent than either individually, suggesting that this hybrid strategy in drug design could lead to novel compounds with improved biological activities," added Grant. "The results also strongly encourage further optimization of compounds 5 and 7 to develop more potent agents as treatment options for multiple myeloma."
Zhang and Grant collaborated on this study with Kai Liu from the Department of Medicinal Chemistry at the VCU School of Pharmacy; Jeremy Chojnacki, from the VCU Department of Medicinal Chemistry; Datong Zhang, from the School of Chemistry and Pharmaceutical Engineering at Shandong Polytechnic University in Jinan, Shandong; and Yuhong Du and Haian Fu, from the Department of Pharmacology and Emory Chemical Biology Discovery Center at Emory University in Atlanta, Georgia.
The full manuscript of this study is available at: http://pubs.rsc.org/en/content/articlepdf/2013/ob/c3ob40595h.
Contact: Alaina Farrish
[email protected]
Virginia Commonwealth University


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Today's Daily Devotional For Women - You are destined to RISE.
Do people ever make you feel like you're not good enough? Then today's devotional is for you. God says you are EXTRAORDINARY
Bible Verse of the Day
Exodus 9:16 - "But I have raised you up for this very purpose, that I might show you my power and that my name might be proclaimed in all the earth."
Today's Daily Devotional for Women
When I was about 14 years old I felt like it was me against the world. There just weren't a lot of people in my life telling me I was worthy of success and destined to fulfill my purpose. Instead, I was told I was rebellious, replaceable, unworthy, mediocre.
And it would be easy to allow those words to dictate my life. It's easy to let those words sink into my spirit and diminish my self-worth. But you know what's hard? Rejecting those lies for exactly what they were – lies about who I am, what I stand for and what the God of this heaven says I am worth.
Because God has called you and me at this time, at this very moment, for the glory of His Kingdom. Your talents, your skill set, your personality, who you are – is for a purpose. It is preordained for God's glory. All that makes you unique is exactly what God needs to shine His light on this earth. It doesn't matter who says you're not good enough or talented enough or smart enough to succeed, because God has already ordained you to RISE.
And because of that, I choose to live my life rejecting what the naysayers says about me and believing what God says about me.
I will rise.
And today it's your turn to believe you'll rise too.
Dear Jesus,
Thank You for seeing me, for creating me, for knowing each hair on my head and each step of my feet. I pray for the strength today to believe in Your purpose for my life and to have confidence in the person You've allowed me to be.
In Jesus' Name I Pray,
Ready To Live Your Purpose?
Ready To Activate God's Greatest Purpose For Your Life With My Free 5-Day Challenge? Sign up to receive my FREE 5-Day Activate Your Purpose challenge that empowers you to:
- Find God's purpose for your life
- Believe your purpose is possible
- Take action on your purpose EVERY single day!
Lovely, I believe that as daughters of a Risen King, every woman – no matter what her age, race, creed or culture – has a RIGHT to live her purpose in Christ! Grab your free challenge now at https://purposelegend.com

subset: commoncrawl


text: Having this Administration Fee separate from the Entry Fee is our clearest way to cover costs and offer the best service possible. This Admin fee covers costs separate from producing the event including: credit card and Paypal fees; IT expenditure; bank fees; administration of the registration database and team member name changes; VAT at 20%. For further information please see our pricing page.


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Trousers - Oatmeal
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Available in 7 delicious pastel colours.
Poppers on the cuffs allow Pop My Way socks to be attached.
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Sleigh Ride is a chubby, blue-gray pitbull, and she'd been hanging around Richmond Animal Care and Control's shelter for quite awhile. But a letter from a second-grader — written on the dog's behalf — may have been the ticket home.
"Do you want to adopt me?" the letter read. "You can snuggle with me! I promise that I will be a good dog. You can even sleep with me if you want!"
Within about 10 days of posting the letter alongside the kennel, someone adopted Sleigh Ride into a fur-ever home, said Christie Chipps Peters, director of Richmond Animal Care and Control.
The letter came from a student in Kensey Jones' writing class at St. Michael's Episcopal School in Richmond, Va. It was part of a persuasive writing assignment — Jones' brainchild — that asked students to write letters in the voice of one of 24 animals — 23 dogs and one cat — at the shelter.
In each letter, the young writers persuaded readers to adopt an assigned pet, from the point of view of the animal.
So far, the students' work has been effective. After posting the letters outside each kennel, only four dogs remain: Pebble, Yosemite, Kotey and I'll Tumble For Ya.
"It was just a miraculous marketing tool to help people find those pets and fall in love with them with the stories that the kids wrote, and then take that pet home with them," Peters told NPR.
When Peters was compiling the dogs to include on the list, she stuck with the ones who are harder to adopt, like ones who had health or behavioral challenges.
Ordinarily, people might walk past these animals without taking a second look, but the letters and matching illustrations encouraged people to slow down, Peters said.
Sunday Special, a tan and white pitbull (who was aptly picked up on a Sunday), also found his home after a second-grader wrote a letter on his behalf. He doesn't always show well, Peters said, and was very afraid of people.
But one student wrote a compelling letter in his voice.
"Hello, my name is Sunday Special," the letter began. "I would love to be adopted. If you do adopt me, I hope I will brighten up your Sundays like the sun! You'll be my Sunday Special and I hope I'll be yours!"
The pup was able to find a home, and Peters is certain the letter was a factor.
"His little story, I'm telling you, is the reason that he got adopted," Peters said.
The students have been enthusiastic throughout the process, Jones tells NPR. It probably helps that Peters brought in Snow, a white pitbull, for a visit with the students. The kids were "so excited and happy and jumping out of their skin" when they met the well-mannered fella, Peters said.
Even though the writing took place in early February, students still ask about the animals they wrote about.
"Has I'll Tumble For Ya been adopted yet?" Jones recalls one student asking before the day's lesson had even started.
Jones says she's watched her students develop an eagerness to write, even beyond this project.
"They are just so excited to use their writing, whether it's to persuade, to inform, to do some research," Jones said.
Jones, who volunteers at the shelter, said she hopes the students learn that "they can do anything," even if they're only 7 or 8 years old. She hopes that other teachers will also partner with their local shelters.
"Make that impact for not only the children, but the dogs that are awaiting their forever home," Jones said.
Copyright 2022 NPR. To see more, visit https://www.npr.org.


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A hushed and taboo topic of conversation that lawyers rarely write much about is what clients and industries are "better" to represent than others.
Their reticence is largely because outside counsel are perennially fearful of offending any potential clients. So, they would rather pretend that "all clients and industries are equal," than openly discuss the vagaries of representing clients that come from very different industries.
But the reality is that representing a small startup client in the media industry will be a totally different experience for the lawyer than counseling and representing an established banking industry client, or a large multinational pharmaceutical company, even if the legal subject matter of the representation is similar.
Each industry and client will have its own pros and cons for the outside counsel, and clients will often have very different expectations of their outside counsel. Here are a few examples:
Large multinational corporations are highly structured and regulated, and have become extremely demanding of their outside vendors.
Over the last decade, most multinational corporations have come to view outside counsel services in the same category as any commodity vendor. This type of treatment often leaves lawyers feeling like their services are being viewed about as uniquely as paper products.
Further, in-house lawyers working for these companies are usually very sophisticated and will pressure their outside counsel to offer extremely unfavorable deals.
Many law firms that regularly represent and counsel Wal-Mart complain that they are required to offer "most favored nation" status to Wal-Mart for their hourly billing rates.
What that demand means, in layman's terms, is that if a law firm offers a special discount to any other client, it is required to offer the same (or better) discount to Wal-Mart.
Consequently, given Wal-Mart's strict "Outside Counsel Guidelines," many lawyers will simply refuse to even consider representing a behemoth, regardless of the volume of work that could be involved. If a lawyer's standard billable rate is $800 an hour, and she must offer a discount down to $475 an hour to Wal-Mart, she may very well end up working for peanuts (relatively speaking, of course).
The reality is that Wal-Mart will have no problem finding another law firm to underbid the legal work, leaving the outside counsel with zero leverage.
Industries can matter more than a client's size. For example, companies in the agriculture and mining industries are notoriously difficult to work for, for a variety of cultural reasons. Agriculture and mining jobs often have lower salaries and workers in these industries are often very unhappy.
Such unhappiness about their career prospects generally can rub off on the outside counsel, who may be seen as charging too much for her time.
Similarly, representing non-profit enterprises and software companies is also notoriously difficult, given the stringent demands on those particular workforces.
According to Forbes, media, entertainment and retail fashion companies tie for the third unhappiest industry to work in. These industries often pay their employees with glitz and glamor rather than cash, and expect their outside counsel to similarly discount their own financial expectations, in exchange for prestige.
Small companies and startups are also a mixed bag. Some outside counsel report that some of their most enjoyable work has been advising smaller companies and startups during their nascent phases.
This satisfaction is in part because these companies often possess wide latitude in making decisions and are not hampered by the extremely top-heavy management styles of large multinational corporations. A lawyer's advice may end up shaping significant business decisions that the client makes.
The obvious downside is that these companies are often so legally unsophisticated that they "need their hand held" by their outside counsel, but may not be in a position to pay the lawyer enough money to remotely justify micromanagement of their day to day legal affairs. Whether a client has an in-house counsel will make a huge difference for the outside counsel.
Individuals are sometimes the most interesting to represent, but perhaps may be the most rewarding and challenging of all. When a lawyer represents a client so small that it may consist of a single individual or family, that relationship will often become very close.
A lawyer may become a trusted advisor affecting all parts of that individual client's life. Some lawyers report becoming so close to their individual client's lives, that they become like family. Of course, such intimacy can lead to obvious tensions, too.
Whether a client is foreign or domestic can make a huge practical and cultural difference, too. For example, lawyers have reported that representing Japanese electronics companies will offer an extremely different experience than representing a midwestern American auto maker.
Similarly, representing a German cellular phone company will be as different as night and day from representing a North Carolina based tobacco company. These clients' unique cultures and expectations will make for very different experiences for their outside counsel.
The reality is that clients are people, too. Each client has its own unique personalities and traits. Clients also function in industries that are often absurdly demanding and, in some cases, dysfunctional due to no fault of the client.
Over the course of her career, the aspiring outside counsel would be well advised to be careful to choose her clients wisely, as the internal and external pressures that the client faces will often affect her own lifestyle, as well.


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Billet Narrow Superlite 4
The Superlite caliper series has set the standard for many years in short track, late model, modified and open wheel competition. It has also enjoyed prominence in a variety of road-race, off-road, rally and sport driving applications. Starting at 4.40 pounds, the Forged Billet Narrow Superlite (FNSLR) is innovation to this series from Wilwood. New and adaptive technologies have been applied providing substantial improvements in strength, fluid volume displacement, and overall performance. FNSL4R calipers are the the only Superlite series calipers with piston dust boots, primarily for export mandates.
The FSL body design is a highly efficient product of computer generated solid modeling and stress analysis technology. Each caliper features closed end bridges with a radial transition to the piston body housings. The elimination of machined steps and sharp shoulders in this critical area provides a measurable increase in overall body strength and resistance to deflection under load. Center bridge bolts replace cotter pins to provide additional support and allow quick access with positive brake pad retention. Clamping force, structural deflection, and volume displacement tests have proven the superior strength and efficiency of the FSL. On-track testing has proven driver satisfaction. The bottom line is better stopping power with less pedal travel.
The superior strength of this innovative new caliper is combined with proven performance features from other Wilwood designs. Each caliper is equipped with Wilwood's replaceable SRS stainless steel bridge plates. SRS plates eliminate the bridge wear caused by pad gouging and extend the service life of the caliper body. The spring-loading action of the SRS plates also eliminates pad rattle and dampens the vibration harmonics that contribute to squeal under braking. Other standard Wilwood features include high-temperature, square faced o-ring seals for positive sealing, controlled piston retraction, and long service life in high heat conditions. Stainless steel pistons are used to resist corrosion and retard heat transfer from the pads. Fluid tubes are vibration dampened to resist stress fractures and reduce damage caused by track debris. Two-piece bleed screw assemblies provide long, reliable service life and are easily replaced if necessary.
Forged Billet Superlite calipers are a direct replacement for all Wilwood Superlite and similar competitive brand calipers with 3.50" centered mounting tabs. Calipers are available in the popular 1.75", 1.62", 1.38", 1.25" and 1.12" piston sizes for .81", 1.10" and 1.25" rotor widths. FSL calipers use the same 7420 type bridge bolt brake pad used in all Superlite 6 piston calipers. The full range of PolyMatrix pad compounds is available to match brake response and heat range to any application.


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Welcome to the QG Network! For the first time ever, all QG series will be brought to one website, for the reader's convenience. Here, you can find the newest episodes of your favorite series, or you can relive vintage episodes from series' of the pas
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Where QWA wrestlers come and RP for the newest action packed episodes.
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Beach - David Schock
Regular price
24" X 12" Unframed
Oil on Canvas
David Schock was born in Boston, Massachusetts in 1962. He holds a degree in Fine Arts from the University of Massachusetts, studied at the Exeter College of Art in England, and at the Art Students League in New York. His instructors included British painter Michael Mayer, and American portrait artists Nelson Shanks, George Passantino, and Aaron Shikler. He began his professional career taking commissions as a portrait painter, and continues to do so, specializing in informal portraits of children.


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This page has been implemented by the United Nations Economic Commission for Europe and contains only governmental/official source information (as well as remarks from the International Road Transport Union).
This space presents information on travel restrictions and border shutdowns by country.
Recent space activity
Supported by the United Nations Economic and Social Commission for Western Asia UN ESCWA members States please send updates to Dr. Yarob Badr (email@example.com) |
Supported by the International Road Transport Union |
IRU hotline: email@example.com |


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Hamilton Used Tire Dealers - Listing of Good Used Tires, Used Car Tires and Used Truck Tires dealers in the Hamilton Ontario area. These used tire dealers that supply good quality used car tires. Find the tires you need at low prices. It is not uncommon to find that many used tires still have only 25% tread wear. Cheap Tires for Leased Vehicle Returns All Brands: Used Bridgestone Tires ,Used Firestone Tires, Used Good Year Tires, Used Michelin Tires, Used UniRoyal Tires, Used Toyo Tires, Used Pirelli Tires
Special Offers: Save on quality tires with these manufacturer's promotions available from Tire Rack.


text: In 1985, a group of women artists founded the Guerrilla Girls. They assumed the names of dead women artists and wore gorilla masks in public, concealing their identities and focusing on the issues rather than their personalities. Between 1985 and 2000, close to 100 women, working collectively and anonymously, produced posters, billboards, public actions, books and other projects to make feminism funny and fashionable. At the turn of the millennium, three separate and independent incorporated groups formed to bring fake fur and feminism to new frontiers. Read More


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With health care moving back to center stage in Washington, we're publishing Dr. Donald Condit's Acton monograph A Prescription for Health Care Reform as a free eBook readable in a variety of formats. This excellent work continues to be available for $6 (paperback) in the Acton Bookshoppe.
For your free eBook, visit Acton's Smashwords page. The Condit book will soon be available in the Kindle store (no charge for that, either) and in other eBook retail sites. We'll keep you updated when they become available.
Via Smashwords, you can download digital versions of the 81-page health care monograph for eBook readers, smart phones and computer screens.
The monograph was released before the passage of the Patient Protection Act in March. Dr. Condit has recently authored an update in the November 2010 issue of the Linacre Quarterly, published by the Catholic Medical Association. The medical association has graciously offered readers of the Acton PowerBlog an open link to Dr. Condit's new article, "Health-Care Counter-Reform."
The Jan. 5 Acton commentary was based on the Linacre article. Read "Obamacare and the Threat to Human Dignity" by Dr. Donald Condit.


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Apple Inc. says it has removed an application called "ThirdIntifada" from its App Store following complaints that it glorified violence against Israel.
Israel's information minister, Yuli Edelstein, requested the company remove the app in an email he sent to Apple CEO Steve Jobs. Jewish human rights group The Simon Wiesenthal Center also complained to Apple.
"Intifada" is the Arabic term for two violent uprisings against Israel over the past two decades. The free application encouraged followers to share opinions and organize protests against Israel.
It linked to a website that helped organize violent clashes with Israeli troops recently along Israel's frontiers with Lebanon and Syria.
Apple spokesman Tom Neumayr said Wednesday the app was removed "because it violates the developer guidelines by being offensive to large groups of people."
(Source: NBC)


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This is a very important message to all of our clients and potential clients, please read carefully as it may affect your ability to use our service in the future.
The International Marriage Broker Regulation Act, IMBRA, was passed as part of the 2005 reauthorization of the Violence Against Women Act (VAWA), and signed into law by President Bush on January 5, 2006.
IMBRA was intended to provide useful information to women who avail themselves of the services of International Matchmaking Agencies. IMBRA requires international matchmakers to do several things, including but not limited to, verifying the women who use the service are eighteen years old or older, and that the men's criminal/marital history is presented to the women, in their own language, prior to any personal contact information being exchanged.
It is important that you as a client of a company only use IMBRA compliant companies because IMBRA has been incorporated into the Fianc�e visa application. If you met your fianc�e via an International Introduction agency you will be asked to produce a copy of the singed and dated IMBRA form, failure to produce that document may result in a delay or denial of your fianc�es Fianc�e (k-1, k-2) or Spousal (k-3) visa. A Foreign Affair has always complied with the existing Federal legislation concerning this industry and will of course comply with the existing IMBRA legislation as well. There are companies providing International Matchmaking service who do not fully comply or simply ignore IMBRA, be very careful of using these companies as it may interfere with your ability to successfully complete the fianc�e visa process and bring your fianc�e to the United States.
If you have any questions regarding IMBRA please call us at (602) 553-8178
A Foreign Affair has always complied with the existing Federal legislation concerning this industry and will of course comply with the new legislation as well. It is very important for you as a client that you only use sites that comply with this legislation if you plan on petitioning the government for a fiancee (K1) visa. If you use a service that does not comply with this legislation you and your fiancee may have difficulties when petitioning for the K1 visa. It is important that the women receive a copy of your personal background information prior to the two of you exchanging any personal contact information.
Again, please click here to read the question and answer page concerning the new legislation. If you still have any questions about this please call us at (602) 553-8178 or (602) 332-7805
Newest, beautiful, single women now added for week of Wednesday, 24 July, 2024 - Tuesday, 30 July, 2024
You have to meet the women to marry them! What other international dating site offers you numerous opportunities to do that?


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Runaway Bicycle
Runaway Bicycle was born in 2014, in a small one-bedroom apartment. Raised during after work hours, Preeti Verma the founder, juggled her day job in advertising to put together a collection borne out of a personal need. To have access to clothes that felt comfortable before looking good. Since then Runaway Bicycle has moved into a modest yet elegant studio trying to give expression to goodness in every sense of the word. A lack of experience in fashion and lifestyle was offset by a knowledge of traditional weaving techniques and a passion to incorporate comfort and beauty into everyday life. Runaway Bicycle's work today, essentially rests in linking the skills of traditional weavers and dyers spread all across India with those of the craftsmen working out of the studio. The collective skills they bring is an accumulation of knowledge passed down through many generations. Eventually resulting in garments and pieces of home décor, that defy trends and seasons, and will be handed down to future generations.
Sorry, there are no products in this collection


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Single Lever Bath Mixer
Basin Faucet
789 Series
Faucet is the common name of water valve, which is used to control the size of the water flow switch, which has the effect of saving water.
Key words:
Water tap
Faucet is the common name of water valve, which is used to control the size of the water flow switch, which has the effect of saving water. The replacement speed of faucets is very fast, from the old cast iron process to the electroplating knob type, and then to stainless steel single-temperature single-control faucet, stainless steel dual-temperature dual-control faucet, kitchen semi-automatic faucet. Nowadays, more and more consumers will buy faucets, and they will consider everything from the aspects of material, function, and shape.
1. According to the material, it can be divided into SUS304 stainless steel, cast iron, all plastic, brass, zinc alloy material faucet, polymer composite faucet and other categories.
2. According to the function, can be divided into basin, bathtub, shower, kitchen sink faucet and electric hot water faucet (porcelain electric hot water faucet), with the improvement of living standards, can quickly heat the faucet (porcelain electric hot water faucet) is more and more popular with consumers, is expected to become the new protagonist leading the faucet revolution.
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Please note : This help page is not for the latest version of Enterprise Architect. The latest help can be found here.
Test Case
A Test Case is a stereotyped Use Case element. You might use it to extend the facilities of the Testing window, by applying element properties and capabilities to the tests of a feature represented by another element or - more appropriately - set of elements. That is, you can define in one go - in the Testing window for the Test Case element - the details of the tests that apply to each of several elements, instead of recording the details separately in each element.
Within the Test Case element properties you can define test requirements and constraints, and associate the test with test files. You can also link the element to Document Artifacts or (in the Corporate, Business and Software Engineering, System Engineering and Ultimate editions) directly to linked documents, such as a Test Plan.
The Test Case element enables you to give greater visibility to tests, in the Project Browser, Diagram List, Package Browser, Model Search, Relationship Matrix, Traceability window and reports.
The Test Case element is available through the Use Case and Maintenance pages of the Toolbox.
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text: Carved into a moving island of ice twice the size of the United States, Ice Station Grendel has been abandoned for more than seventy years. The twisted brainchild of the finest minds of the former Soviet Union, it was designed to be inaccessible and virtually invisible. But an American undersea research vessel has inadvertently pulled too close--and something has been sighted moving inside the allegedly deserted facility, something whose survival defies every natural law. And now, as scientists, soldiers, intelligence operatives, and unsuspecting civilians are drawn into Grendel's lethal vortex, the most extreme measures possible will be undertaken to protect its dark mysteries--because the terrible truths locked behind submerged walls of ice and steel could end human life on Earth.


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Brushing Habits to Break
Brushing your teeth has become a staple in your routine since you were a child, working every day to maintain a strong and healthy smile. Your 14221 dentist understands that there are some habits you can easily fall into, especially ones that you may not even notice are harmful! Thankfully, that's what we're here for. Below, we'll break down some brushing habits that could be doing more damage to your teeth than good.
Keeping Your Toothbrush for Too Long
Even though your toothbrush doesn't look any different after three months use, we still recommend getting a brand new one. The bristles will start to fray and break with months and months of use, which is one of the most notable signs that you'll need to switch your brush. With a brand-new toothbrush, your teeth will be getting the best possible scrub to get rid of the food particles and bacterial build-up.
Not Brushing for Two Minutes
By brushing your teeth for two minutes, twice a day, you're ensured to reach and properly clean the intricate, small spaces of your mouth. We know that two minutes seems like a long time, so we recommend keeping a timer on hand if you think you're not meeting this time. The average time that people brush their teeth for is around 45 seconds, which isn't nearly long enough, so be sure to slow it down – and don't forget to brush your tongue, too!
Using a Brush with Rough Bristles
It's a common misconception that rough toothbrush bristles will give you a better cleaning. While scrubbing hard on some surfaces will get the dirt out, that isn't the case for your smile. The surface of your teeth, called your enamel, is very sensitive and if it's weakened or damaged by rough bristles, you could experience dental sensitivity and have a tough time enjoying hot or cold food and drinks. Be sure to use a soft-bristled toothbrush on your teeth and gums during your dental routine.
Are there any other teeth-brushing tips that you're looking for to get the healthiest smile? Don't hesitate to ask your 14221 dentist by giving us a call at (716) 580-3339 today. Make sure to schedule your next cleaning, too!


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Win a $100.00 Amazon Gift Card by joining the MyChesCo Thanksgiving Sweepstakes. Enter daily to increase your chances of winning.
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MyChesCo Thanksgiving Sweepstakes will run from September 1, 2020, 12:00 AM, until November 26, 2020, at 11:59 PM. We will select one winner at random. The grand prize will be a one hundred U.S. dollars ($100.00) Amazon gift card will be sent to the winner at the email address provided with their entry.
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Fig.1. My mash-up from the Start Writing Fiction, OU and FutureLearn MOOC.
Many weeks after the Open University MOOC on Future Learn closed 'Start Writing Fiction' I find I am returning to the many activities across the eight weeks to refresh, reflect, and build on my knowledge. As well as doing my bit for that 'community' by doing a few reviews (all assignments are peer reviewed). I completed the course in early December.
I return to reflect, to develop ideas, to be reminded of the excellent lessons I have learnt there, and in particular on how we use fact and fiction, whether consciously or not. In pure fantasy writing I find, inevitably, that I ground events in places I know from my youth, or have since researched. I use the hook of reality and my experiences on which to build the fiction. While currently I am embedded in what started as 90/10 fiction to fact I find it is increasingly looking like 95/5 in favour of fact as my imagination is close to the truth about a particular character and his experience of the First World War. All this from a simple exercise in week one called 'Fact or Fiction?' where we are asked first of all two write something that contains three factual elements and one fiction, and then to write something that contains three fictional elements and one factual. There are thousands of these now, many very funny, original or captivating. In week one, I'm guessing that around 10,000 got through the week. How many posted? There are 967 comments. This happens. It is an open course. The same applies for most web content: 95:5 is the ratio of readers to writers. Many people prefer not to do what they feel is 'exposing themselves' online. Why should they.
Anyway, this gives me reason to argue that it is an excellent idea to keep a blog of your OU studies. All of this can remain private, but at least, as I know have in this blog, when the doors close behind a module you can, months, even years later, return to key activities and assignments and build on the lessons you learnt. More importantly, as we all forget with such ease, we can keep the memory of the lessons fresh.


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Consultant & Trainer
Benjamin Day Consulting, Inc.
Benjamin Day is a consultant and trainer specializing in software best practices using Microsoft tools. Ben's main areas of emphasis include Team Foundation Server, Scrum, software testing, and software architecture. He is a Microsoft Visual Studio ALM MVP, a certified Scrum trainer via Scrum.org, and a speaker at conferences such as TechEd and Visual Studio Live! When not developing software, Ben's been known to go running and sea kayaking in order to balance out his love of cheese, cured meats, and champagne. He can be contacted via www.benday.com.


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Barkeley K-9 University is a mobile, in-home dog training company based in the East Bay of San Francisco. Headed up by dog trainer, Patrick Gibbons, BK9U has over ten years of training experience to draw from to help you and your dog. If you have always wanted a dog that does cool tricks and is polite and obedient, or you have a real tough case on your hands, we can help. Using current dog training methods we can teach you and your dog in a way that is not only effective but enjoyable as well.
Our Dog Training services are designed to be fun and effective so you and your dog enjoy training. We offer a variety of training options to fit your needs, whether you want lessons on how to train your dog yourself or if you want to have your dog trained for you we can help.
In any of our training options we believe it is equally important for the owner to be educated, as well as the dogs. When the owners are educated along with their dogs they are better able to work out the little bumps in the road that inevitably come up.
See What Barkeley K-9 University's Dog Training Can Do For You and Your Dog…


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MAZAR-E-SHARIF, (Reuters) – A suicide bomber killed at least 40 people in a mosque in Afghanistan's relatively peaceful north on Friday as worshippers gathered for prayers marking the Muslim Eid al-Adha holiday, police officials said.
The attack in Maimana, capital of Faryab province, also wounded 40, regional police chief General Abdul Khaliq Aqsai said, pinning the blame on the Taliban. A Taliban spokesman said they were investigating to find out who was responsible.
"The suicide bomber detonated explosives when our countrymen were congratulating each other on the Eid holiday," said Lal Mohammad Ahmadzai, spokesman for the police in the Afghan north, adding that almost half of the dead were police.
He said Aqsai appeared to be the target. "As soon as the police chief got in his vehicle, the bomber detonated his explosives," Ahmadzai said
About 20 bodies, some in police uniform, lay in front of the mosque's gates as smoke billowed above.
The attack, at around 9 a.m. local time on the first day of Eid, came just before President Hamid Karzai repeated his call for the Taliban to join the government.
"If you (Taliban) want to come to the government, you are welcome. You have rights as an Afghan and as a Muslim," he said in a speech marking Eid in the capital, Kabul.
Kabul and Washington have been seeking separate peace negotiations with the Taliban as the 2014 deadline looms for most foreign troops to leave.
Karzai condemned the mosque attack in a statement.
Violence is intensifying across the country 11 years into the NATO-led war, sparking concerns over how the 350,000-strong Afghan security forces, often the target of the Taliban, will manage once most foreign troops leave.
The Taliban, in a statement released to media on Friday, said two Afghan soldiers were behind the attack in western Farah province on Thursday that killed one Italian soldier.
One of them later joined the Taliban, the statement said, along with the policeman who killed two U.S. soldiers in southern Uruzgan province on Thursday.
That attack was the latest insider attack, when Afghan security forces turn their weapons on their foreign mentors and partners. At least 54 members of the NATO-led force have been killed this year so far in insider attacks, which have been eroding trust between Kabul and its western backers.


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TCL Industries Holdings Co., Ltd. (the "Company") has recently been made aware of certain scams fraudulently using the name of the Company and its subsidiaries or associated companies, and fraudsters faking identities as the staff of the Company or the authorized distributors to carry out the following fraudulent activities: Learn More
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We stand by the quality of all of our pre-owned watches and mechanical objects. If something goes wrong, we'll always strive to remedy the situation in a timely manner and to the best of our ability. The satisfaction and trust of our clients is of the highest importance, to everyone at A Collected Man.
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If you are under strong plasma/scalar attack, the so-called Violet Ray device can help you. By applying the wand in your auric field you can remove negative plasma generated there by the scalar attack:
Please understand that although the article above might be ideologically biased, most of hard science facts still stand. Just insert Khazarians instead of Semites/Jews when you read the article.


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Ideologues may set the tone for the national debate, but geography and demography determine elections.
In America, the dominant geography continues to be suburbia – home to at least 60 percent of the population and probably more than that portion of the electorate. Roughly 220 congressional districts, or more than half the nation's 435, are predominately suburban, according to a 2005 Congressional Quarterly study. This is likely to only increase in the next decade, as Millennials begin en masse to enter their 30s and move to the periphery.
Now the earth is shaking under suburban topsoil -- in ways that could be harmful to Democratic prospects. "The GOP path to success," according to a recent Princeton Survey Research Associates study of suburban attitudes, "goes right through the suburbs."
The connection between suburbs and political victory should have been clear by now. Middle- and working-class suburbanites keyed the surprising election win of Republican Sen. Scott Brown in Massachusetts in January. Suburban voters were also crucial to the 2009 Republican gubernatorial victories in Virginia and New Jersey, two key swing states.
Nationally, suburban approval for the Democrats has dropped to 39 percent this year, from 48 percent two years ago. Disapproval for President Barack Obama is also high --- nearly 48 percent of suburbanites disapprove, compared to only 35 percent of urbanites. Even Obama's strong support among minority suburbanites, a fast-growing group, has declined substantially.
Many suburban voters, notes Lawrence Levy, executive director of the National Center for Suburban Studies at Hofstra University, appear to be undergoing "buyer's remorse" for backing Obama and the Democrats last time around .
Much of the suburban distress, of course, stems from the still perilous state of the economy. Obama's mix of fiscal and monetary policies has provided much succor to Wall Street, where stock prices have soared 30 percent, and to big corporations, whose profits have risen by 42 percent. This has been great for Manhattan plutocrats -- but not particularly helpful for the suburban middle class.
Indeed the indicators most important to suburbanites – private sector employment, weekly earnings, home prices and disposable income – have all stagnated or even fallen since Obama took office. Fifty-three percent of suburban residents, according to the Princeton study, described their financial situation as "bad." The vast majority have either lost their job or know someone who has lost theirs. Almost 40 percent have either lost their home or know someone who did – up from 27 percent in 2008.
Given the stubbornness of this recession, neither the current administration or Congress gets credit for improving conditions. Barely 10 percent of suburbanites polled think the stimulus helped, one-third thought it hurt and the rest said it made little difference.
But there may be other, perhaps more nuanced, reasons for the administration's suburban disconnect. Many of the administration's most high-profile initiatives have tended to reflect the views of urban interests – roughly 20 percent of the population – rather than suburban ones.
When the president visits suburban backyards, it sometimes seems like a visit from a "president from another planet." After all, as a young man, Obama told The Associated Press: "I'm not interested in the suburbs. The suburbs bore me."
More recently, Obama made clear that he is more interested in containing suburbia than enhancing it. In Florida last February, the president declared, "the days of building sprawl" are "over."
Much of the Obama policy agenda – from mass transit and high-speed rail to support for "smart growth" policies – appeals to city planners and urbanistas. Transportation Secretary Ray LaHood has spoken openly of "coercing" Americans out their cars and the Department of Housing and Urban Development is handing out grants to regions which support densification strategies that amount to forced urbanization of suburbs.
This is a problem since the vast majority of Americans – consistently more than 80 percent – do not prefer to live in dense big cities. Most want a house rather than being forced to live in an apartment. And for all but a handful, a car, not a bus or train, remains not only the preferred way to get to work, but often the only feasible means to get work -- mostly in the suburbs.
If the Democrats want to mount an electoral comeback in suburbia, they need to take these realities into account . There are just not enough votes in core cities, upscale close-in suburbs or college towns to knit together a majority.
Recovering suburbia s is not impossible for Democrats. Obama himself proved this in 2008, by essentially tying for the suburban vote -- a remarkable achievement. Bill Clinton won in 1992 and especially 1996 by competing well in suburbs and exurbs. In the last two election cycles, the shift of suburbanites to the Democrats keyed the party's steady gains in the Congress – accounting for, according to GOP sources, as many as 24 seats in the last two congressional elections.
Most important, suburbanite identification with the Republican Party has continued to erode over the past two years, according to the Princeton survey. Instead the big winners have been independents, who have grown to 36 percent from 30 percent of the suburban electorate.
These voters, for the most part, also tend to be less strident in their cultural views than either secular urbanites or rural evangelicals. More than one in five suburbanites is an ethnic minority -- which could also help the Democrats.
But to win even these suburban voters, the Democrats must offer solutions to suburbanites that go beyond devising their forced conversion to dense urbanity. They could refocus their efforts on climate change to suburbs-friendly strategies like telecommuting -- perhaps the cheapest, quickest and most socially acceptable way to cut down on greenhouse gas emissions.
Outside of greater New York, which has half the nation's transit users, there are already about as many telecommuters as transit riders. Why not work to expand this phenomena, so well suited to the vast majority of the country?
These suburb friendly approaches should be examined as the Democrats reflect on what many expect to be midterm electoral setbacks. They can only compete successfully on a national basis by jettisoning their apparent disdain toward the aspirations of suburban homeowners and begin treating them with respect.
This article originally appeared at Politico.
Joel Kotkin is executive editor of NewGeography.com and is a distinguished presidential fellow in urban futures at Chapman University. He is author of The City: A Global History. His newest book is The Next Hundred Million: America in 2050, released in February, 2010.
Photo by Caesar Sebastian


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The game is coming to PC and Mac in Spring of 2020, followed by Switch shortly thereafter, and possibly other consoles.
To find more promising 2D games currently under development, be sure to check out our Master List.
Showcasing promising new 2D games
that are currently under development
An enhanced edition of a bombastic arcade actioner, from Mitchell Corporation and ININ Games
An open world platformer inspired by Crazy Taxi, from Sinclair Strange
An open world action-adventure that takes place across multiple planets, from PolarityFlow
A tough and bloody DOS-style shooter, from Alexey Goryachev
An open world action-adventure featuring 2D animation and 3D environments, from Petoons Studio