text:
St. Juliana of Lazarevo (Feast Day - January 2) |
By St. Dimitri of Rostov
During a moment of ardent supplication to God, the great Christian ascetic Macarius of Egypt heard a voice from heaven, saying: "Macarius! thus far thou hast not attained the spiritual level of two women who live in the town nearby!" The elder straightway took his staff in hand and went to seek out the righteous women of whom the voice from on high had spoken. After a lengthy search, he knocked on the door of a certain house in the town, and two women admitted him with kindness. Macarius said to them: "I have left the desert specifically to meet you, that I might acquaint myself with your works. Tell me of yourselves." "O man of God," the women answered, abashed, "can one expect anything God-pleasing from those who are continually occupied with domestic tasks and must need fulfill the responsibilities of marriage?" But the ascetic persisted, asking the women to disclose to him their manner of life. And they answered him, saying: "We are two sisters-in-law, the wives of brethren. For fifteen years we have lived together, and all throughout that time we have not spoken to each other a single word in vexation. We do not have children, but if the Lord will grant them, we will entreat Him to help us raise them in the faith and in piety. We treat our servants with kindness. Many times we have taken counsel one with another as to whether we ought to enter a community of nuns, but our husbands have declined to give us their permission. And seeing their love for us, we have resolved not to part with them, but to serve them with diligence. Yet to make our life a little like that of the holy desert-dwellers, we have set it in our hearts to avoid loud conversations, to remain at home as much as possible, to take care of the running of our household." To this the venerable Macarius said: "Truly God doth not look to see who is a virgin or who is married, who is a monastic or who is in the lay state, but only looketh for the inclination of the heart toward good deeds. This He accepteth, and in accordance therewith He sendeth the Holy Spirit down upon anyone who desireth to be saved. And the Holy Spirit, the Comforter, directeth the thoughts and will of such a one to the everlasting life of heaven."
In Russia, the merciful Juliana provided just such a example of piety and spiritual purity as the women had revealed to the venerable Macarius in the East, in Christian antiquity. Her life teaches us that even in the world, even within a family, amid cares for children, spouse and members of one's household, one may please God no less than one who withdraws from the world to a monastic cell: one only need live according to the demands of the love of Christ and the righteousness of the Gospel. The merciful Juliana was born in Moscow, in the palace milieu, to pious and philanthropic parents named Justin and Stephanida Nedyurev. Her father served as the steward at the court of Tsar Ivan IV Vasilievich, known as the Terrible. Justin and Stephanida lived in all reverence and purity, with their sons and daughters, and a multitude of servants, possessed of great riches. Into their family the blessed Juliana was born in the 1530s. When she was six years old, she lost her mother, and was taken to be raised by her maternal grandmother, Anastasia Lukina, and removed from Moscow to the outskirts of the city of Murom. Yet six years later the righteous Juliana's grandmother passed away, leaving the twelve-year old orphan to be raised by her aunt, Juliana's grandmother's daughter, Natalia Arapova, who had many children of her own: eight daughters and one son.
It is well known that brothers and sisters do not always live in peace and goodly concord; and it is even more common for disputes and quarrels to arise among more distant kinfolk if they live together. The venerable Juliana honored her aunt, was obedient to her in all and unfailingly humbled herself before her cousins, the children of the household, enduring in silence their insults and reproaches. Yet throughout her life Juliana did not resemble her cousins: she had no love for the games, pastimes and pranks which are the pursuits of youth, but gave herself over to fasting and prayer. This difference in temperament between Juliana and her cousins became the cause of mockery and ridicule not only among her cousins, but also among the servants; and under the influence of her children, Juliana's aunt frequently upbraided her orphaned niece. "O foolish one!" she would often say to Juliana, "why art thou mortifying thy body at such an early age? Dost thou wish to ruin thy virginal beauty?" At times, they had to compel the orphan to eat and drink by force. Yet the meek, quiet and dutiful Juliana always remained steadfast and immovable when the matter concerned the salvation of her soul and the God-pleasing life.
The taunts and ridicule of her relatives and servants had no affect upon Juliana: she led the same strict and ascetical life as before. The games and merry songs of her peers held no fascination for her; rather, they provoked in her only displeasure and incomprehension. Since she held herself aloof from girlish amusements and pass-times, Juliana gave herself over with intense commitment to her handiwork: the needlework which flourished in the homes of the nobility in that age, especially spinning and sewing at embroidery-frames. The righteous one spent her evenings in such pursuits. Yet Juliana did not labor for herself: she made clothes for homeless orphans, widows and the sick of her village. And she labored for them indefatigably, without taking sufficient food, drink or rest. Word of her philanthropy spread to the outlying region, and all who heard of it marvelled at her virtuous life. What is particularly striking is that Juliana's exalted humility and boundless love for her neighbors sprang forth only from the depths of her own pure heart, full of Christian meekness. She had no guides and teachers; she was unable either to read the sacred Scriptures or to derive instruction therefrom; during the years of her girlhood she did not even attend church, for there was none nearby.
When Juliana reached the age of sixteen, she was married by the priest Patapius to George Ossorgin, a rich merchant of Murom, in the village of Lazarevo, which was on Ossorgin's estate. After the wedding ceremony, the priest delivered to the newlyweds a discourse on how they should live, how they should raise their children in the fear of God, how they should instill virtue in the members of their household and, in general, make of their family a little church. The words of the priest penetrated deeply into the soul of Juliana, and she followed them devoutly all throughout her life. Her father-in-law, Vasily, and her mother-in-law, Eudocia, were wealthy people well known at the court of the tsar, possessed of many servants and several commodious residences. Besides George, their only son, they had two daughters. By her calm and meek character, her personal kindness and welcoming attitude, Juliana won the love not only of her husband's parents, but even of her sisters-in-law, which was unusual for those times. Distant kinfolk of the Ossorgins and close friends of the family all fell in love with her. They asked her various questions, so as to obtain some idea of her character, but she disarmed her questioners with her constant kindness and goodness, her meek and soft replies, and little by little won the love even of those who at first were reluctant to extend their regard to her. Thus Juliana came to occupy the most visible place in the family of her husband, and became the mistress of the household. The cares and concerns of the household and its economy did not take up all the attention of the blessed Juliana and did not occupy her soul to its detriment: rising early in the morning or resting from the day's cares and turmoil before going to sleep, she would pray long to God and make a hundred or more full prostrations; and she drew her husband to take part regularly in this continual and fervent supplication.
George Ossorgin was often summoned to serve in the tsar's army in Astrakhan' and other faraway places, and he was often away from his home for as many as three years. While she was parted from her husband, under the influence of her natural sorrow, Juliana would spend whole nights in prayer, or at her spinning and sewing. The products of her handiwork she would sell, distributing to poor the moneys thus obtained. Moreover, as a skilled seamstress, the blessed one would sew shrouds and donate them to the church. She kept her benefactions a secret from her husband's parents. She would send a trusted handmaid forth at night to distribute her alms. She cared for widows and orphans like a true mother, washed them with her own hands, fed them, gave them drink and sewed clothing for them. She ran a well-ordered household, where everyone knew what tasks he was expected to perform, yet she was always kind and meek with the servants, always addressing them by their full Christian names, never employing nicknames. She never required her servants to wait on her hand and foot: no one poured the water as she washed her hands, no one helped her dress or removed her shoes, as was usual in most of the households of the nobility. If in the presence of guests, as was customary, she had to rely on such ministrations by her servants, when the guests departed she would bow down and say of herself: "Who am I that I should be served by others, who are also created by God?" On the contrary, she was ever ready to serve others herself, and she made certain that her servants had nourishing food and proper clothing. Yet the righteous Juliana was not satisfied merely to look after the food and vesture of her servants: she strove to see that there were no quarrels and arguments among them, so that peace and quiet, and the grace of God, reigned in her home. Whenever quarrels would arise among her servants, Juliana would frequently take the blame upon herself, and thus placate those who were at enmity. Furthermore, she was wont to say: "I often sin before God, and He, being full of loving-kindness, forgiveth me. Therefore, I will be patient with my servants' sins. Even though they are subject to my authority, yet in soul they can be better than me and more pure before God." She never complained about the faults of the servants to her husband or his parents, who scolded the righteous one for excessive leniency. Whenever she lacked the skill and strength to cope with spoiled servants and restore peace and tranquility to the household, she would pray fervently to the all-holy Virgin and to Saint Nicholas the Wonderworker, asking their help.
During one such trying time, while Juliana stood in prayer at night, the demons struck fear into her heart. She fell senseless upon her bed and plunged into a deep sleep. In a dream she saw a multitude of unclean spirits advancing upon her with swords. "If thou dost not stop what thou art doing," said the demons, "we will destroy thee forthwith!" The blessed Juliana cried out in prayer to the Mother of God and Saint Nicholas, and the holy wonderworker appeared with a large book and drove away the dark spirits, who vanished like smoke. After this, he blessed the merciful Juliana and said: "My daughter, be of good cheer and be strong. Fear not the wiles of the demons. Christ hath commanded me to defend thee against demons and evil men." When she awoke, Juliana clearly beheld a radiant man, who passed through the door of her bed-chamber and disappeared. She ran after him, but the bolts and bars of her quarters had not been moved. Then Juliana understood that the Lord had indeed sent her a heavenly protector: she was strengthened in her faith and hope in the help of God, and with yet greater diligence continued her works of almsgiving and love for her neighbors.
It happened that, in the year 1570, a great famine struck the Russian land, and multitudes of people died from lack of grain. The merciful Juliana drew supplies from her mother-in-law, ostensibly for her own breakfast and noon meals, but secretly distributed all to the starving and poor. Her mother-in-law was amazed at this, and said: "I rejoice that thou hast begun to eat more often, yet I am astonished that thou hast altered thy usual habit. Before, when there was plenty of everything, thou didst take no food in the morning and at noon, and I was unable to prevail upon thee to do so. But now, when there is everywhere a shortage of bread, thou takest both breakfast and the noonday repast." So as not to disclose her secret almsgiving, the blessed Juliana replied to her mother-in-law: "While I had not yet given birth to children, I had no desire to eat those meals; but now I have become weak from birthgiving, and I wish to eat not only during the day, but also at night. But I am ashamed to ask you for food at night." Juliana's mother-in-law was delighted that her daughter-in-law had begun to eat more, and began to send her food even at night. The merciful Juliana accepted the food and distributed it all in secret during the famine. When any of the poor of the surrounding area would die, she would purchase a shroud and provide funds to cover the cost of the funeral. She prayed for the soul of everyone buried in the village of Lazarevo, whether known to her or not.
When the famine passed, a new misfortune befell Russia: a deadly contagion descended upon the hapless land. Filled with horror, the people shut themselves up in their homes and would not allow those infected with the plague to enter; they were even afraid to come in contact with their clothing. Yet the merciful Juliana, unbeknownst to her husband's parents, would wash the sick in the bath-house, treat them as far as she was able, and besought the Lord for the restoration of their health. And whenever any orphan or pauper died, she would wash him with her own hands and hire someone to help bear him away for burial.
The parents of Juliana's husband died at an advanced age, and, according to the custom of their forebears, received the monastic tonsure on their death-beds. Juliana's husband was not at home at that time: he had been serving in the tsar's army at Astrakhan' for more than three years. The blessed Juliana buried Basil and Eudocia Ossorgin with honor, distributed lavish alms for the repose of their souls, had requiem liturgies celebrated each day for forty days, set forth tables of foodstuffs for the monks, priests, widows, orphans and the indigent, and also dispatched abundant donations to the prisons. And afterwards, every year, she kept the memory of her husband's depart parents and expended a sizeable portion of the family's revenue on this good work.
The blessed Juliana lived peaceably and quietly with her husband for many years, and the Lord gave her ten sons and three daughters. Of them, four sons and two daughters died in childhood. Her remaining children she raised, finding joy in them. But when her children grew to adulthood, the enemy of the human race sowed enmity between them and the servants of the blessed one, despite her desire to bring about peace between the disaffected. Her eldest son was even murdered by a servant; and not long afterward, her second son was killed while serving in the tsar's army. A bitter burden were these tribulations to Juliana's maternal heart, yet she did not cry aloud, she did not tear the hair from her head as other women were wont to do: unceasing prayer and almsgiving strengthened her powers. Her husband also grieved over the loss of his sons, but the blessed one consoled him. Under the influence of these familial misfortunes, Juliana began to press her husband to permit her to retire to a convent, and she even let it be known that she was prepared to depart secretly, but George reminded her of the beautiful words that the priest had spoken at their wedding, and the admonitions of other fathers: "Black garments will not save us if we do not live monastically, and white garments will not destroy us if we do what is pleasing unto God. If anyone departeth to a monastery, not desiring to care for children, he seeketh not the love of God, but rather peace. And the children, orphaned, will often weep and curse their parents, saying: 'Wherefore, having given birth to us, hast thou left us in tribulation and suffering?' If it is commanded to feed the orphans of others, it followeth that one ought not to starve one's own children!" The husband of the righteous Juliana was a lettered man. And he read to her other passages from spiritual writers until he had persuaded her. And she said to him: "Let the will of the Lord be done!"
After this, husband and wife began to live as brother and sister. George continued to sleep in his usual bedroom, but Juliana lay down on the stove in the evenings, spreading firewood, branches uppermost, to sleep on instead of a bed, and positioning her ring of iron keys beneath her side. Thus she would fall into a slumber for an hour or two. When the house grew quiet, the blessed Juliana would rise for prayer, and would often spend whole nights in supplication; in the morning she would go to church for matins and liturgy. After the divine services, the merciful Juliana would return home and occupy herself with the running of her household. On Mondays and Wednesdays the blessed one would eat but once a day, and on Fridays she would take no food at all, but would withdraw into a separate room, setting up in her home the semblance of the cell of a monastic recluse. And she would permit herself only a single cup of wine on Saturdays, when she fed the clergy, widows, orphans and poor.
Ten years after she and her husband suspended their marital relations, Juliana's husband died. When she had buried and commemorated him according to custom, as she had her husband's parents, the merciful Juliana gave herself over wholly to the service of God and the poor. Since her children grieved mightily over the loss of their father, she consoled them, saying: "Be not sorrowful, my children! The death of your father is for the edification of us sinners. Seeing it, and continually expecting our own departure from this life, be ye virtuous. Above all, love one another, and give alms." And the blessed Juliana did not teach by means of words alone: she strove also to emulate by her manner of life the great Christian strugglers, the holy women of whom her husband and other literate people had read to her. Whenever she was free from domestic concerns, the blessed Juliana gave herself over to prayer and intensified her fasting. Yet she concerned herself most of all with almsgiving.
Often she would have no money left to distribute to the poor. In wintertime she would receive money from her children to buy warm clothing for herself, but she gave it all to the poor, and she herself went about in thin garments and barefoot. In order to struggle for the Lord in ascetic labors, and, experiencing pain, to fan the flame of her prayer to God, the Bestower of joy and consolation, she placed broken nut-shells between her bare feet and her sandals, and thus walked about her house. One year, there was an exceptionally cold winter, so that even the ground froze through and cracked. Juliana came down with a cold and did not attend church for a time, but she prayed at home. One day, the priest of the village of Lazarevo came to church early in the morning and heard a voice issuing forth from the icon of the Theotokos, saying: "Go and ask Juliana the merciful why she hath not been coming to church. Her prayer at home is pleasing unto God, yet not as pleasing as supplication made in church. And do ye render homage to her: she hath passed the age of sixty, and the Holy Spirit resteth upon her!" Filled with awe and fear, the priest hastened to Juliana, fell at her feet, asked her to forgive him, and told her of the vision he had witnessed. The blessed one was greatly saddened and said to the priest: "Thou hast surely fallen into temptation to say these things! How can I, a sinner before the Lord, be worthy of such a call?" The priest promised Juliana not to speak of his vision while she was alive, but declared that he would make it known after her repose. Then Juliana went to church; there she had a service of supplication offered before the icon of the Mother of God, and she kissed it and entreated the heavenly intercessor with tears.
The blessed one's widowhood lasted for ten years, during which she distributed practically all her possessions to the poor. She retained for her household only what was most necessary and arranged that her supplies of stored food not be carried over from one year to the next. All that remained from the year's stores she immediately passed on to the poor, the orphans and indigent. Then came the hapless reign of Tsar Boris Godunov (1598-1605), and the Lord punished the Russian land with a famine of unusual intensity: the starving people even had to resort to eating carrion, and in certain cases were driven to consume human corpses. Countless multitudes perished of starvation. The house of the Ossorgin family was also affected by the dearth food, for the sowers had not gone forth to plant the fields, and even the cattle died from lack of fodder. The blessed Juliana begged her children and servants not to take anything that belonged to others. Everything that remained in her house of clothing, livestock and vessels, she sold, buying grain with the money she received. With these funds she fed her household, and despite the terrible lack, she also helped the poor, so that not one of them departed from her empty-handed. When there was no more grain left, the merciful Juliana did not become discouraged, but placed all her trust on the help of God. Eventually, the blessed one was forced to move to the village of Vochnevo, on the outskirts of Nizhni Novgorod, where some food was still obtainable. Yet even there the famine soon hit with full force, and Juliana, no longer able to feed her servants, set them at liberty. Some of them took advantage of their freedom, but others remained to endure want and grief with their mistress.
Juliana ordered the servants who remained with her to gather pig-weed and to strip the bark from a certain species of elm-tree. With these she prepared a type of bread with which to feed herself, her children and servants. Through her prayers, the bread made from pig-weed and elm-bark turned out to be quite tasty, and the poor, of whom there were an extraordinarily great number because of the famine, came in multitudes to receive it from the merciful Juliana. Her neighbors asked the poor: "Wherefore go ye to the house of Juliana? She and her children are barely alive in their hunger!" But the poor answered: "We have travelled through many villages, and sometimes we have been given pure wheat-bread; but we have never tasted bread as sweet as that given out by this widow!" The neighbors, who had quite a store of pure wheat, sent to ask Juliana for some of her pig-weed and elm-bark bread, and they were convinced that it was indeed very sweet; yet they attributed this to the skill of the servants who prepared the dough.
While enduring grievous want for two years, the righteous Juliana was not troubled, did not resort to grumbling and complaints, did not become despondent, but was of good cheer and as joyous as was her wont. One thing alone gave her cause for sadness: there was not a church in the village of Vochnev, and because of her advanced age she was unable to visit the church in the nearest village. Yet mindful of how the domestic prayer of the centurion Cornelius was pleasing to God [Acts 10: 31], the blessed one gave herself over to supplication and quickly found peace for her soul. On the 26th of December, 1603, the merciful Juliana fell ill. Her sickness continued for six days, yet she lay in bed only during the daytime, while at night she rose and stood in prayer without any support. Her handmaidens mocked her, saying: "What kind of a sick woman is this? During the day she lieth abed, but at night she standeth in prayer!" But the blessed one answered those who mocked her meekly: "Why do ye laugh? Do ye not know that the Lord expecteth even the sick to pray?"
On January 2nd, when day broke, the merciful Juliana summoned her spiritual father, the priest Athanasius, and received communion of the Holy Mysteries. Then she sat up in her bed and called her children and servants to her. Much did she teach them of how to live a God-pleasing life, and said also: "When I was still a child, I had a strong desire to be tonsured and given the great angelic habit, yet I was not deemed worthy of this, because of my sins. Glory to the righteous judgment of God!" She ordered a censer prepared for her burial and incense placed in it, and having bidden farewell to her children, handmaid and friends, she stretched out upon the bed, made the sign of the Cross thrice over herself, wrapped her prayer-rope around her hands, and uttered her last words: "Glory to God for all things! Into Thy hands, O Lord, do I commit my spirit!" When the blessed one reposed in the Lord, everyone present saw how a splendid light formed around her head in the guise of a golden crown, such as one sees on the icons of the saints. When they washed the body of the newly-departed and had it placed in a separate storeroom, at night they saw burning candles (although no one had lit them), and sensed a sweet fragrance emanating from the room where the blessed one lay. During the night following on the day of the her repose, the merciful Juliana appeared to one of her handmaids and ordered her to see that her body was carried from Vochnev to the Murom region and buried by the church of the righteous Lazarus, next to that of her husband. The body of the blessed, which had seen so many labors, was placed in an oaken coffin and borne away to the village of Lazarevo, about three miles from Murom, and was there interred on January 10th, 1604.
In the years to come, the children and kinfolk of the merciful Juliana erected a winter church, dedicated to the Archangel Michael, over her gravesite. On August 8th, 1614, the blessed one's son George died, and as they began to prepare a burial place for him in the crypt of the Ossorgin family, they found the coffin of the blessed Juliana intact, though they were unaware of the identity of the coffin's occupant. On August 10th, after George's funeral service, when those who had taken part in the ritual went to the house of the Ossorgins to commemorate the departed, the curious women of the village opened the coffin and saw that it was full of fragrant myrrh. When the guests left the commemorative meal, the women reported what they had seen to the Ossorgin family. The children of the merciful Juliana hastened to the coffin and saw that the women's report was true. In reverent fear they took away a small vessel of the myrrh and carried it to the cathedral of Murom, probably as evidence of their report. During the daytime this myrrh was like unto the juice of beets, but at night it thickened and became like attar exuded by some purple flower. In their awe they did not dare to inspect the whole body of the righteous Juliana: they saw only that her hands and legs were intact; they did not see her head, because a beam which supported the church's furnace lay across the lid of the coffin. That night, many heard a bell ring in the church of the righteous Lazarus, and they hastened to the church, thinking that someone was sounding the fire tocsin; yet there was no conflagration to be extinguished anywhere. Those who arrived noticed that a sweet fragrance was being emitted from the coffin. Word of this happening spread quickly to the outlying areas, and many came to the saint's coffin, anointed themselves with the myrrh and received healing for their divers ailments. When the myrrh had been almost completely distributed, the sick began to take the sand from beneath the coffin of the merciful Juliana, rubbed it on themselves and, according to the measure of their faith, received the alleviation of their infirmities.
Thus, Jeremiah Chervev, a resident of Murom, went to the coffin of the merciful Juliana with his wife and two sick children. His son and daughter were afflicted with a disease which had caused blood to flow from their hands and feet for more than two years, and they were unable even to lift their hands to their mouths. Having had a service of supplication and a panikhida chanted at the coffin of the holy Juliana and rubbed some of the sand upon their children, Jeremiah and his wife returned to their home. Their children slept for a full day and night, and when they awoke they were able to make the sign of the Cross freely. Within a week their health had been completely restored.
A peasant from the village of Makarova suffered from a terrible dental affliction and had long been unable to eat, drink or work. On the advice of his wife, he went to the coffin of the merciful Juliana alone at noon-time, prayed to the blessed one, rubbed some of the sand on his teeth and returned to his home well.
One night, a fire broke out in the village of Lazarevo and consumed four lead-roofed cabins. An extraordinarily powerful wind was blowing, and the fire gradually grew closer to the church. The priest ran to the church, hurriedly took soil from beneath Saint Juliana's coffin in both hands, and cast it at the fire. The wind then changed direction, the fire died down little by little, and finally went out.
A peasant from the village of Koledino, by the name of Clement, had an abscess on his leg which gave him much discomfort. The sick man, having heard of the miracles wrought by the blessed Juliana, asked his friends to carry him to her coffin; there he had a service of supplication offered, rubbed soil from the saint's grave on his ulcer, and quickly received a cure.
Maria, a servant of the nobleman Matthew Cherkasov, who lived in a suburb of Murom, became blind. When her friends and family brought her to the shrine of the holy Juliana and had a service of supplication and a panikhida offered up for her, she sensed that her sight was returning. On the way back to Murom she was even able to pick mushrooms and berries.
A certain ten-year old boy became paralyzed and lost his sight. He was carried to the Church of the Archangel Michael, where a service of supplication was offered up to the righteous Juliana, and the sick child suddenly could see a burning candle; in a short time he completely regained his health.
Agatha, the wife of Theodore, a clergyman who served in the Church of the Archangel Michael, contracted a condition of the hand which was so painful that she was unable to move it. The merciful Juliana appeared to the unfortunate woman and said: "Go to the Church of the Archangel Michael and kiss the icon of Juliana." Then the saint identified the place where the sick woman had hidden two coins and commanded her to give them to the priest to touch to the icon. The ailing woman did all that she was told: she had a service of supplication and a panikhida offered, drank holy water, rubbed the sand on her hand, and was healed.
Joseph Kovkov, a courtier of Moscow, was grievously ill, to the point where it was expected that he would soon die. But the thought came to him to have his servant Anicius go to the shrine of the righteous Juliana. The servant had a service of supplication offered up for the health of his ailing master, and took with him holy water and sand. When Kovkov sprinkled himself with the water and rubbed himself with the sand which had been brought to him, he immediately recovered his health. The cured man then travelled to the village of Lazarevo on foot, to give thanks to the merciful Juliana.
Apolytikion in the Fourth Tone
Shining forth with grace divine, even after death thou hast revealed the radiance of thy life; for thou pourest forth fragrant myrrh for healing, upon all the sick who approach the shrine of thy relics with faith. O venerable mother Juliana, entreat Christ God, that our souls be saved.
Kontakion in Plagal of the Fourth Tone
All of us amid misfortune and pain hymn the holy Juliana as a helper quick to hear; for she lived a God-pleasing life in the world and gave countless alms to the poor. Wherefore, she hath found the grace of miracles at the command of God.


text:
If you remember, some time ago we reviewed a project for a clone HP15c calculator made in Switzerland. While the project was extremely interesting, it had the worst possible timing: it coincided with the reissue of the HP15c by Hewlett Packard. With good sense, the creators backed off and re-thought the project, in order to give the user something more than the original did.
I am carrying the HP15c Limited Edition every day with me, and while its size is smaller than most calculators, it is a tight fit in my shirt's pocket, and it fits well in my jacket's; but sometimes I would like it to be smaller.
Enter the HP15cc:
First a pre-production sample
Then a more developed sample:
I look forward to get one. and you?

subset: commoncrawl


text:
The functions eval and compile are required to ensure that literal objects referenced within the resulting interpreted or compiled code objects are the same as the corresponding objects in the source code. compile-file, on the other hand, must produce a compiled file that, when loaded with load, constructs the objects defined by the source code and produces references to them.
In the case of compile-file, objects constructed by load of the compiled file cannot be spoken of as being the same as the objects constructed at compile time, because the compiled file may be loaded into a different Lisp image than the one in which it was compiled. This section defines the concept of similarity which relates objects in the evaluation environment to the corresponding objects in the run-time environment.
The constraints on literal objects described in this section apply only to compile-file; eval and compile do not copy or coalesce constants.
22.214.171.124 Externalizable Objects
22.214.171.124 Similarity of Literal Objects
126.96.36.199 Extensions to Similarity Rules
22.214.171.124 Additional Constraints on Externalizable Objects


text:
Big, destructive hurricanes are hitting the U.S. three times more frequently than they did a century ago, according to a new study.
Experts generally measure a hurricane's destruction by adding up how much damage it did to people and cities. That can overlook storms that are powerful, but that hit only sparsely populated areas. A Danish research team came up with a new measurement that looked at just the how big and strong the hurricane was, not how much money it cost. They call it Area of Total Destruction.
"It's the most damaging ones that are increasing the most," said study lead author Aslak Grinsted, a climate scientist at the University of Copenhagen. "This is exactly what you would expect with climate models."
Looking at 247 hurricanes that hit the U.S. since 1900, the researchers found the top 10 percent of hurricanes, those with an area of total devastation of more than 467 square miles (1,209 square kilometers), are happening 3.3 times more frequently, according to a study in Monday's Proceedings of the National Academy of Sciences.
Eight of the 20 storms with the highest area of total destruction since 1900 have happened in the last 16 years, a much larger chunk than would randomly occur, Grinsted said.
Two storms stood out from the rest: 2017′s Hurricane Harvey, with an area of total destruction of 4,570 square miles (11,835 square kilometers), and 2005′s Katrina, at 2,942 square miles (7,621 square kilometers). The average was 159 square miles (411 square kilometers) — which means Harvey's destructive footprint was 30 times larger than average.
Climate scientists have predicted and shown that higher temperatures in the oceans and the atmosphere, a result of burning coal, oil and other fuels, is creating more extreme weather and storms.
"Their result is consistent with expected changes in the proportion of the strongest hurricanes and is also consistent with the increased frequency of very slow-moving storms that make landfall in the U.S.," said National Oceanic and Atmospheric Administration hurricane scientist Jim Kossin, who was not part of the research.
Other experts weren't so convinced, however. Colorado State University hurricane scientist Phil Klotzbach says his review of the most powerful storms to hit the U.S., using barometric pressure, shows no increase.
Follow Seth Borenstein on Twitter at @borenbears .
The Associated Press Health and Science Department receives
from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content.


text:
Transcript: XIST:47
Basic information
LNCipedia transcript ID: XIST:47
LNCipedia gene ID: XIST
Location (hg38): chrX:73820614-73849001
Strand: -
Class: intergenic
Sequence Ontology term: lincRNA
Transcript size: 9857 bp
Exons: 7
Sources: FANTOM CAT (stringent)
Alternative transcript names: ENSG00000229807.5|HBMT00001549399.1
Alternative gene names: NCRNA00001; DXS1089; swd66; LINC00001
RNA sequence:
Protein coding potential
In stringent set: yes
Locus conservation
Locus conservation? | ||||
XIST:47 | no | no | no | no |
Available literature
- Briese (2016), Whole transcriptome profiling reveals the RNA content of motor axons., Nucleic Acids Res.
- Dixon-McDougall (2016), The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome., Biochem. Cell Biol.
- Richard (2016), Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and Its Implications in Disease Conditions., Curr. Top. Microbiol. Immunol.
- Sun (2016), Involvement of lncRNA dysregulation in gastric cancer., Histol. Histopathol.
- Xie (2016), Long non-coding RNAs in colorectal cancer., Oncotarget
- Yue (2016), Dynamic interplay and function of multiple noncoding genes governing X chromosome inactivation., Biochim. Biophys. Acta
- Briggs (2015), Single-Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells., Stem Cells
- Cabili (2015), Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution., Genome Biol.
- Cajigas (2015), Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling., Development
- Cerase (2015), Xist localization and function: new insights from multiple levels., Genome Biol.
- Chacko (2015), The lncRNA RZE1 Controls Cryptococcal Morphological Transition., PLoS Genet.
- Chen (2015), Differential lncRNA expression profiles in recurrent gliomas compared with primary gliomas identified by microarray analysis., Int J Clin Exp Med
- Chen (2015), Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA., Sci Rep
- Ching (2015), Non-coding yet non-trivial: a review on the computational genomics of lincRNAs., BioData Min
- Chu (2015), Systematic discovery of Xist RNA binding proteins., Cell
- Fang (2015), Probing Xist RNA Structure in Cells Using Targeted Structure-Seq., PLoS Genet.
- Fiedler (2015), Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization., J. Am. Coll. Cardiol.
- Galupa (2015), X-chromosome inactivation: new insights into cis and trans regulation., Curr. Opin. Genet. Dev.
- Guo (2015), Biological significance of long non-coding RNA FTX expression in human colorectal cancer., Int J Clin Exp Med
- Hu (2015), NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2., Oncotarget
- Jiao (2015), Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line., Oncol Lett
- Kelsey (2015), Impact of flanking chromosomal sequences on localization and silencing by the human non-coding RNA XIST., Genome Biol.
- Kota (2015), Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome., Chromosoma
- Lalevée (2015), Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies., Epigenomics
- Li (2015), LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns., Oncotarget
- Lorenzen (2015), Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury., Clin. Chem.
- Mao (2015), Oxamflatin treatment enhances cloned porcine embryo development and nuclear reprogramming., Cell Reprogram
- Minajigi (2015), Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation., Science
- Na (2015), Long non-coding RNA UCA1 contributes to the progression of prostate cancer and regulates proliferation through KLF4-KRT6/13 signaling pathway., Int J Clin Exp Med
- Nwigwe (2015), Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions., PLoS ONE
- Peffers (2015), Transcriptome analysis of ageing in uninjured human Achilles tendon., Arthritis Res. Ther.
- Pei (2015), Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5., Int J Clin Exp Med
- Peng (2015), Epigenetic regulation of drug metabolism and transport., Acta Pharm Sin B
- Qi (2015), X chromosome inactivation in human parthenogenetic embryonic stem cells following prolonged passaging., Int. J. Mol. Med.
- Quek (2015), lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs., Nucleic Acids Res.
- Rupaimoole (2015), Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis., Cell Rep
- Sarkar (2015), An Xist-activating antisense RNA required for X-chromosome inactivation., Nat Commun
- Scarola (2015), Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA., Nat Commun
- Shang (2015), A global view of network of lncRNAs and their binding proteins., Mol Biosyst
- Shen (2015), Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer., Oncotarget
- Smolle (2015), Long Non-Coding RNAs in Endometrial Carcinoma., Int J Mol Sci
- Sun (2015), Chromosome X genomic and epigenomic aberrations and clinical implications in breast cancer by base resolution profiling., Epigenomics
- Tantai (2015), Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer., Int J Clin Exp Pathol
- Wang (2015), Identification of lncRNA-associated competing triplets reveals global patterns and prognostic markers for cancer., Nucleic Acids Res.
- Wang (2015), Long noncoding RNA derived from CD244 signaling epigenetically controls CD8+ T-cell immune responses in tuberculosis infection., Proc. Natl. Acad. Sci. U.S.A.
- Wang (2015), Upregulated lncRNA-UCA1 contributes to progression of lung cancer and is closely related to clinical diagnosis as a predictive biomarker in plasma., Int J Clin Exp Med
- Wang (2015), Serum LncRNAs Profiles Serve as Novel Potential Biomarkers for the Diagnosis of HBV-Positive Hepatocellular Carcinoma., PLoS ONE
- Werner (2015), Nuclear Fractionation Reveals Thousands of Chromatin-Tethered Noncoding RNAs Adjacent to Active Genes., Cell Rep
- Wongtrakoongate (2015), Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes., PLoS Genet.
- Wu (2015), The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma., Oncotarget
- Wu (2015), The converging roles of BRD4 and gene transcription in pluripotency and oncogenesis., RNA Dis
- Xiao (2015), Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPα., Stem Cell Reports
- Xu (2015), A transposable element within the Non-canonical telomerase RNA of Arabidopsis thaliana modulates telomerase in response to DNA damage [corrected]., PLoS Genet.
- Yang (2015), The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation., Genome Biol.
- Yao (2015), Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152., Cancer Lett.
- Zhang (2015), Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value., Biomed Res Int
- Zlotorynski (2015), Non-coding RNA: X-chromosome inactivation unravelled., Nat. Rev. Mol. Cell Biol.
- Alaimo (2014), ncPred: ncRNA-Disease Association Prediction through Tripartite Network-Based Inference., Front Bioeng Biotechnol
- Alam (2014), Promoter analysis reveals globally differential regulation of human long non-coding RNA and protein-coding genes., PLoS ONE
- Almlöf (2014), Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes., PLoS ONE
- Basu (2014), Using amino-labeled nucleotide probes for simultaneous single molecule RNA-DNA FISH., PLoS ONE
- Bhatnagar (2014), Genetic and pharmacological reactivation of the mammalian inactive X chromosome., Proc. Natl. Acad. Sci. U.S.A.
- Chakraborty (2014), The predictive power of synthetic nucleic acid technologies in RNA biology., Acc. Chem. Res.
- Chapman (2014), Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding., BMC Genet.
- Cifuentes-Rojas (2014), Regulatory interactions between RNA and polycomb repressive complex 2., Mol. Cell
- Cooper (2014), Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells., Genes (Basel)
- Ding (2014), Long intergenic non-coding RNAs (LincRNAs) identified by RNA-seq in breast cancer., PLoS ONE
- Feinberg (2014), The nucleolus gets the silent treatment., Cell Stem Cell
- Feng (2014), Methods for the study of long noncoding RNA in cancer cell signaling., Methods Mol. Biol.
- Figueiredo (2014), Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions., PLoS Genet.
- Gendrel (2014), Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation., Annu. Rev. Cell Dev. Biol.
- Giorgetti (2014), Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription., Cell
- Guallar (2014), RNA-binding proteins in pluripotency, differentiation, and reprogramming., Front Biol (Beijing)
- Ha (2014), A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements., BMC Genomics
- Hacisuleyman (2014), Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre., Nat. Struct. Mol. Biol.
- Hu (2014), A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer., Cancer Cell
- Huang (2014), Urinary Xist is a potential biomarker for membranous nephropathy., Biochem. Biophys. Res. Commun.
- Ishizuka (2014), Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1., Genes Cells
- Jiang (2014), Xist deficiency and disorders of X-inactivation in rabbit embryonic stem cells can be rescued by transcription-factor-mediated conversion., Stem Cells Dev.
- Li (2014), starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data., Nucleic Acids Res.
- Li (2014), A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses., PLoS ONE
- Li (2014), Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma., Mol Med Rep
- Liu (2014), LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray., World J. Gastroenterol.
- Luo (2014), High-resolution chromosomal microarray analysis of early-stage human embryonic stem cells reveals an association between X chromosome instability and skewed X inactivation., Cell Biosci
- Makhlouf (2014), A prominent and conserved role for YY1 in Xist transcriptional activation., Nat Commun
- Marques Howarth (2014), Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis., J. Clin. Invest.
- Mathiyalagan (2014), Interplay of chromatin modifications and non-coding RNAs in the heart., Epigenetics
- McKiernan (2014), Long noncoding RNA are aberrantly expressed in vivo in the cystic fibrosis bronchial epithelium., Int. J. Biochem. Cell Biol.
- Minkovsky (2014), The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation., Epigenetics Chromatin
- Negishi (2014), A new lncRNA, APTR, associates with and represses the CDKN1A/p21 promoter by recruiting polycomb proteins., PLoS ONE
- Nielsen (2014), Identification of expressed and conserved human noncoding RNAs., RNA
- Olivier-Van Stichelen (2014), X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body., Front Genet
- Pasque (2014), X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency., Cell
- Payer (2014), Coupling of X-chromosome reactivation with the pluripotent stem cell state., RNA Biol
- Pestell (2014), Long and noncoding RNAs (lnc-RNAs) determine androgen receptor dependent gene expression in prostate cancer growth in vivo., Asian J. Androl.
- Pircher (2014), Ribosome-associated ncRNAs: an emerging class of translation regulators., RNA Biol
- Porro (2014), TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres., Cell Rep
- Prensner (2014), The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc., Neoplasia
- Quagliata (2014), Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients., Hepatology
- Quinn (2014), Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification., Nat. Biotechnol.
- Quinodoz (2014), Long noncoding RNAs: an emerging link between gene regulation and nuclear organization., Trends Cell Biol.
- Rajpathak (2014), Human 45,X fibroblast transcriptome reveals distinct differentially expressed genes including long noncoding RNAs potentially associated with the pathophysiology of Turner syndrome., PLoS ONE
- Rinn (2014), RNA Function. RNA and dynamic nuclear organization., Science
- Sarma (2014), ATRX directs binding of PRC2 to Xist RNA and Polycomb targets., Cell
- Shichino (2014), Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1., Open Biol
- Soma (2014), Ftx is dispensable for imprinted X-chromosome inactivation in preimplantation mouse embryos., Sci Rep
- Song (2014), A long non-coding RNA, GAS5, plays a critical role in the regulation of miR-21 during osteoarthritis., J. Orthop. Res.
- Su (2014), Comprehensive analysis of long non-coding RNAs in human breast cancer clinical subtypes., Oncotarget
- Sultan (2014), Influence of RNA extraction methods and library selection schemes on RNA-seq data., BMC Genomics
- Sun (2014), A novel antisense long noncoding RNA within the IGF1R gene locus is imprinted in hematopoietic malignancies., Nucleic Acids Res.
- Wang (2014), The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489., Circ. Res.
- Yang (2014), A network based method for analysis of lncRNA-disease associations and prediction of lncRNAs implicated in diseases., PLoS ONE
- Yoon (2014), PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity., Nat Commun
- Yue (2014), Quick fluorescent in situ hybridization protocol for Xist RNA combined with immunofluorescence of histone modification in X-chromosome inactivation., J Vis Exp
- Zhang (2014), Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers., BMC Genomics
- Zhao (2014), Comprehensive characterization of cancer subtype associated long non-coding RNAs and their clinical implications., Sci Rep
- de Oliveira Georges (2014), Aberrant patterns of X chromosome inactivation in a new line of human embryonic stem cells established in physiological oxygen concentrations., Stem Cell Rev
- Agostini (2013), X-inactivation: quantitative predictions of protein interactions in the Xist network., Nucleic Acids Res.
- Akbari (2013), Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio., G3 (Bethesda)
- Alaei-Mahabadi (2013), Limited evidence for evolutionarily conserved targeting of long non-coding RNAs by microRNAs., Silence
- Amort (2013), Long non-coding RNAs as targets for cytosine methylation., RNA Biol
- Batista (2013), Long noncoding RNAs: cellular address codes in development and disease., Cell
- Beato (2013), A new role for an old player: steroid receptor RNA Activator (SRA) represses hormone inducible genes., Transcription
- Bhan (2013), Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol., J. Mol. Biol.
- Bhartiya (2013), lncRNome: a comprehensive knowledgebase of human long noncoding RNAs., Database (Oxford)
- Bhattacharjee (2013), Combinatorial control of gene expression., Biomed Res Int
- Bischoff (2013), Differences in X-chromosome transcriptional activity and cholesterol metabolism between placentae from swine breeds from Asian and Western origins., PLoS ONE
- Bolisetty (2013), Circuitous route to transcription regulation., Mol. Cell
- Chadwick (2013), Molecular versatility: the many faces and functions of noncoding RNA., Chromosome Res.
- Dasen (2013), Long noncoding RNAs in development: solidifying the Lncs to Hox gene regulation., Cell Rep
- Dimond (2013), Molecular biology. Long noncoding RNAs Xist in three dimensions., Science
- Disteche (2013), How to correct chromosomal trisomy., Cell Res.
- Donley (2013), Asynchronous replication, mono-allelic expression, and long range Cis-effects of ASAR6., PLoS Genet.
- Fan (2013), A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells., Exp Ther Med
- Guan (2013), Switching cell fate, ncRNAs coming to play., Cell Death Dis
- Hangauer (2013), Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs., PLoS Genet.
- He (2013), ANRIL/CDKN2B-AS shows two-stage clade-specific evolution and becomes conserved after transposon insertions in simians., BMC Evol. Biol.
- Jalali (2013), Systematic transcriptome wide analysis of lncRNA-miRNA interactions., PLoS ONE
- Jiang (2013), Translating dosage compensation to trisomy 21., Nature
- Juan (2013), Potential roles of microRNAs in regulating long intergenic noncoding RNAs., BMC Med Genomics
- Kapusta (2013), Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs., PLoS Genet.
- Kogure (2013), Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer., Genes Cancer
- Kung (2013), RNA in the loop., Dev. Cell
- Lai (2013), Activating RNAs associate with Mediator to enhance chromatin architecture and transcription., Nature
- Lawrence (2013), Interview: from Down's syndrome to basic epigenetics and back again., Epigenomics
- Li (2013), Targeted disruption of Hotair leads to homeotic transformation and gene derepression., Cell Rep
- Liu (2013), Identification of differentially expressed long non-coding RNAs in human ovarian cancer cells with different metastatic potentials., Cancer Biol Med
- Lu (2013), Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis., EMBO J.
- Luco (2013), The non-coding genome: a universe in expansion for fine-tuning the coding world., Genome Biol.
- Maclary (2013), Long nonoding RNAs in the X-inactivation center., Chromosome Res.
- Maenner (2013), ATP-dependent roX RNA remodeling by the helicase maleless enables specific association of MSL proteins., Mol. Cell
- McGraw (2013), Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females., PLoS Genet.
- Minks (2013), XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells., Epigenetics Chromatin
- Papait (2013), Long noncoding RNA: a new player of heart failure?, J Cardiovasc Transl Res
- Sado (2013), Advances in understanding chromosome silencing by the long non-coding RNA Xist., Philos. Trans. R. Soc. Lond., B, Biol. Sci.
- Salvador (2013), The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression., Clin. Cancer Res.
- Santoro (2013), Silencing by the imprinted Airn macro lncRNA: transcription is the answer., Cell Cycle
- Sheffield (2013), Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions., Genome Res.
- Simon (2013), High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation., Nature
- Szafranski (2013), Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder., Genome Res.
- Vallot (2013), XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells., Nat. Genet.
- Vallot (2013), [X chromosome inactivation in human: XACT and XIST, a non coding RNA for each X]., Med Sci (Paris)
- Vallot (2013), Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome., RNA Biol
- Volders (2013), LNCipedia: a database for annotated human lncRNA transcript sequences and structures., Nucleic Acids Res.
- Wan (2013), Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway., Cell. Signal.
- Weinberg (2013), Long non-coding RNA targeting and transcriptional de-repression., Nucleic Acid Ther
- Wood (2013), Sense-antisense gene pairs: sequence, transcription, and structure are not conserved between human and mouse., Front Genet
- Wu (2013), Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma., Gastroenterology
- Wu (2013), Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins., Biochemistry
- Yi (2013), RNA-seq identified a super-long intergenic transcript functioning in adipogenesis., RNA Biol
- Zhang (2013), Circular intronic long noncoding RNAs., Mol. Cell
- Ørom (2013), Long noncoding RNAs usher in a new era in the biology of enhancers., Cell
- Amos-Landgraf (2012), The many ways to open the gate to colon cancer., Cell Cycle
- Anguera (2012), Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes., Cell Stem Cell
- Augoff (2012), miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer., Mol. Cancer
- Bovolenta (2012), The DMD locus harbours multiple long non-coding RNAs which orchestrate and control transcription of muscle dystrophin mRNA isoforms., PLoS ONE
- Bánfai (2012), Long noncoding RNAs are rarely translated in two human cell lines., Genome Res.
- Cabianca (2012), A long ncRNA links copy number variation to a polycomb/trithorax epigenetic switch in FSHD muscular dystrophy., Cell
- Cabianca (2012), A novel molecular mechanism in human genetic disease: a DNA repeat-derived lncRNA., RNA Biol
- Derrien (2012), The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression., Genome Res.
- Flockhart (2012), BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration., Genome Res.
- Glazko (2012), Computational prediction of polycomb-associated long non-coding RNAs., PLoS ONE
- Grant (2012), Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation., Nature
- Jalali (2012), Integrative transcriptome analysis suggest processing of a subset of long non-coding RNAs to small RNAs., Biol. Direct
- Li (2012), AS1DHRS4, a head-to-head natural antisense transcript, silences the DHRS4 gene cluster in cis and trans., Proc. Natl. Acad. Sci. U.S.A.
- Maenner (2012), Roles of long, non-coding RNA in chromosome-wide transcription regulation: lessons from two dosage compensation systems., Biochimie
- Markaki (2012), The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture: 3D structured illumination microscopy of defined chromosomal structures visualized by 3D (immuno)-FISH opens new perspectives for studies of nuclear architecture., Bioessays
- Maruyama (2012), Altered antisense-to-sense transcript ratios in breast cancer., Proc. Natl. Acad. Sci. U.S.A.
- Miyagawa (2012), Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles., RNA
- Naganuma (2012), Alternative 3'-end processing of long noncoding RNA initiates construction of nuclear paraspeckles., EMBO J.
- Niazi (2012), Computational analysis of functional long noncoding RNAs reveals lack of peptide-coding capacity and parallels with 3' UTRs., RNA
- Novikova (2012), Structural architecture of the human long non-coding RNA, steroid receptor RNA activator., Nucleic Acids Res.
- Pei (2012), The GENCODE pseudogene resource., Genome Biol.
- Pinter (2012), Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations., Genome Res.
- Pollex (2012), Recent advances in X-chromosome inactivation research., Curr. Opin. Cell Biol.
- Sati (2012), Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci., Nucleic Acids Res.
- Tilgner (2012), Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs., Genome Res.
- Troy (2012), Genetic "lnc"-age of noncoding RNAs to human disease., J. Clin. Invest.
- Vizoso (2012), The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy., Cell Res.
- Wilusz (2012), HuR and translation--the missing linc(RNA)., Mol. Cell
- Arthold (2011), Mechanistic insights into chromosome-wide silencing in X inactivation., Hum. Genet.
- Bruck (2011), Meta-analysis of the heterogeneity of X chromosome inactivation in human pluripotent stem cells., Stem Cell Res
- Chaumeil (2011), Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammals., PLoS ONE
- Chureau (2011), Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region., Hum. Mol. Genet.
- Derrien (2011), [Long non-coding RNAs with enhancer-like function in human cells]., Med Sci (Paris)
- Duszczyk (2011), The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization., RNA
- Hasegawa (2011), Revisiting the function of nuclear scaffold/matrix binding proteins in X chromosome inactivation., RNA Biol
- Horvath (2011), Comparative analysis of the primate X-inactivation center region and reconstruction of the ancestral primate XIST locus., Genome Res.
- Jeon (2011), YY1 tethers Xist RNA to the inactive X nucleation center., Cell
- Knowling (2011), Non-coding RNA and antisense RNA. Nature's trash or treasure?, Biochimie
- Morris (2011), Modulation of gene-specific epigenetic states and transcription by non-coding RNAs., Clin Epigenetics
- Nakagawa (2011), eXIST with matrix-associated proteins., Trends Cell Biol.
- Navarro (2011), [Epigenetic reprogramming: the importance of X inactivation]., Med Sci (Paris)
- Okamoto (2011), Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development., Nature
- Paralkar (2011), A new 'Linc' between noncoding RNAs and blood development., Genes Dev.
- Salmena (2011), A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?, Cell
- Saxena (2011), Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs., Bioessays
- Splinter (2011), The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA., Genes Dev.
- Weakley (2011), Expression and function of a large non-coding RNA gene XIST in human cancer., World J Surg
- Zhao (2011), Molecular and DNA methylation analysis of Peg10 and Xist gene in sheep., Mol. Biol. Rep.
- Hall (2010), XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome., Cold Spring Harb. Symp. Quant. Biol.
- Hasegawa (2010), The matrix protein hnRNP U is required for chromosomal localization of Xist RNA., Dev. Cell
- Kaneko (2010), Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA., Genes Dev.
- Kanhere (2010), Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2., Mol. Cell
- Lengner (2010), Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations., Cell
- Maenner (2010), 2-D structure of the A region of Xist RNA and its implication for PRC2 association., PLoS Biol.
- Marchetto (2010), A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells., Cell
- Moreira de Mello (2010), Random X inactivation and extensive mosaicism in human placenta revealed by analysis of allele-specific gene expression along the X chromosome., PLoS ONE
- Sarma (2010), Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome., Proc. Natl. Acad. Sci. U.S.A.
- Tchieu (2010), Female human iPSCs retain an inactive X chromosome., Cell Stem Cell
- Zhao (2010), Genome-wide identification of polycomb-associated RNAs by RIP-seq., Mol. Cell
- Deakin (2009), Unravelling the evolutionary origins of X chromosome inactivation in mammals: insights from marsupials and monotremes., Chromosome Res.
- Hanna (2009), Direct cell reprogramming is a stochastic process amenable to acceleration., Nature
- Kanellopoulou (2009), X chromosome inactivation in the absence of Dicer., Proc. Natl. Acad. Sci. U.S.A.
- Elisaphenko (2008), A dual origin of the Xist gene from a protein-coding gene and a set of transposable elements., PLoS ONE
- Hall (2008), X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected., J. Cell. Physiol.
- Ogawa (2008), Intersection of the RNA interference and X-inactivation pathways., Science
- Shen (2008), X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations., Proc. Natl. Acad. Sci. U.S.A.
- Silva (2008), X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells., Proc. Natl. Acad. Sci. U.S.A.
- Zhao (2008), Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome., Science
- Davidow (2007), The search for a marsupial XIC reveals a break with vertebrate synteny., Chromosome Res.
- Hore (2007), The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals., Chromosome Res.
- Shevchenko (2007), Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials., Chromosome Res.
- Zhang (2007), Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing., Cell
- Chaumeil (2006), A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced., Genes Dev.
- Duret (2006), The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene., Science
- Blackshaw (2004), Genomic analysis of mouse retinal development., PLoS Biol.
- Wutz (2002), Chromosomal silencing and localization are mediated by different domains of Xist RNA., Nat. Genet.
- Beletskii (2001), PNA interference mapping demonstrates functional domains in the noncoding RNA Xist., Proc. Natl. Acad. Sci. U.S.A.
- Csankovszki (2001), Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation., J. Cell Biol.
- Wutz (2000), A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation., Mol. Cell
- Csankovszki (1999), Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation., Nat. Genet.
- Marahrens (1997), Xist-deficient mice are defective in dosage compensation but not spermatogenesis., Genes Dev.
- Sheardown (1997), Stabilization of Xist RNA mediates initiation of X chromosome inactivation., Cell
- Clemson (1996), XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure., J. Cell Biol.
- Penny (1996), Requirement for Xist in X chromosome inactivation., Nature
- Brockdorff (1992), The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus., Cell
- Brown (1992), The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus., Cell
- Borsani (1991), Characterization of a murine gene expressed from the inactive X chromosome., Nature
- Brockdorff (1991), Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome., Nature
- Brown (1991), A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome., Nature
LNCipedia transcript ID history
LNCipedia version | LNCipedia transcript ID |


text:
This web site https://www.bigfishaquarium.com.au/ is owned and operated by Luke and Jenna Mahoney and will be referred to as "We", "our" and "us" in this Privacy Policy (Privacy Policy). By using this site, you agree to the Privacy Policy. The Privacy Policy relates to the collection and use of personal information you may supply to us through your conduct on the web site.
We reserve the right, at our discretion, to modify or remove portions of this Privacy Policy at any time. This Privacy Policy is in addition to any other terms and conditions applicable to the web site.
We recognise the importance of protecting the privacy of information collected about visitors to our web site, particularly information that is capable of identifying an individual ("personal information"). This Privacy Policy governs the manner in which your personal information, obtained through the web site, will be dealt with. This Privacy Policy should be reviewed periodically so that you are updated on any changes. We welcome your comments and feedback.
Personal Information
- Personal information about visitors to our site is collected only when knowingly and voluntarily submitted. For example, we may need to collect such information to provide you with further services or to answer or forward any requests or enquiries. It is our intention that this policy will protect your personal information from being dealt with in any way that is inconsistent with applicable privacy laws in Australia.
- Personal information collected may include, but not be limited to: name, email address, mailing address, phone number, etc. Users may refuse to provide personal information, except that such refusal may prevent them from utilising some or all of the services provided on the site.
Use of Information
- Personal information that visitors submit to our site is used only for the purpose for which it is submitted or for such other secondary purposes that are related to the primary purpose, unless we disclose other uses in this Privacy Policy or at the time of collection.
- Copies of correspondence sent from the web site, that may contain personal information, are stored as archives for record-keeping and back-up purposes only.
- We may from time to time, use your personal information to contact you about: important changes to our services, planned service outages, any communication necessary for the provision of agreed services to you, and promotional materials if you have consented to receiving them.
Collecting information on Registered members
- As part of registering with us, we collect personal information about you in order for you to take full advantage of our services. To do this it may be necessary for you to provide additional information to us as detailed below.
- Registration is completely optional. Registration may include submitting your name, email address, address, telephone numbers, and option on receiving updates and promotional material and other information. You may access this information at any time by logging in and going to your account.
Credit Card Details
- Credit Card details are only stored for the processing of payments and will be deleted once payment is processed.
- Apart from where you have consented or disclosure is necessary to achieve the purpose for which it was submitted, personal information may be disclosed in special situations where we have reason to believe that doing so is necessary to identify, contact or bring legal action against anyone damaging, injuring, or interfering (intentionally or unintentionally) with our rights or property, users, or anyone else who could be harmed by such activities.
- We may disclose personal information in compliance with a court order, co-operation with criminal investigations, other situations in which we reasonably believe disclosure is required to comply with laws, and to prevent or minimise harm to personal or public safety.
- We may engage third parties to provide you with goods or services on our behalf. In that circumstance, we may disclose your personal information to those third parties in order to meet your request for goods or services.
- From time to time, we may need to transfer your information to overseas entities that are not subject to same level of privacy protections as Australia. Reasons for this may include: backup storage, and provision of services by third parties. When this is required, we will notify you and obtain consent for this transfer.
- We strive to ensure the security, integrity and privacy of personal information submitted to our sites, and we review and update our security measures in light of current technologies. Unfortunately, no data transmission over the Internet can be guaranteed to be totally secure.
- However, we will endeavour to take all reasonable steps to protect the personal information you may transmit to us or from our online products and services. Once we do receive your transmission, we will also make our best efforts to ensure its security on our systems.
- In addition, our employees and the contractors who provide services related to our information systems are obliged to respect the confidentiality of any personal information held by us. However, we will not be held responsible for events arising from unauthorised access to your personal information.
Links to external websites
- Our websites may contain hyperlinks to websites not controlled by us. We cannot and do not provide assurances of privacy and information security related to such websites.
Collecting Information from Users
- IP Addresses
Our web servers gather your IP address to assist with the diagnosis of problems or support issues with our services. Again, information is gathered in aggregate only and cannot be traced to an individual user.
- Cookies
We may use cookies to provide you with a better experience. These cookies allow us to increase your security by storing your session ID and are a way of monitoring single user access. This aggregate, non-personal information is collated and provided to us to assist in analysing the usage of the site. Users may choose to disable cookies, but this may result in loss of some or all of the site's functionality.
- Applets
Applets are small programs embedded within web pages to provide interactivity that is not able to be facilitated by standard HTML code. Some applets may collect limited information about you (such as computer hardware and software parameters) in order to provide interactive capability and content.
- Non-personal Information
Certain non-personal information may also be collected by the site. This may include: browser name, the type of computer and technical information about a user's means of connection to our site, such as the operating system and the Internet service provider utilised and other similar information. This information is used to customise the user's experience of our site, and to assist in managing the site and its supporting infrastructure.
Google Adsense
- Some of the ads may be served by Google. Google's use of the DART cookie enables it to serve ads to users based on their visit to our site and other sites on the Internet. DART uses "non-personally identifiable information" and does NOT track personal information about you, such as your name, email address, physical address, etc. You may opt out of the use of the DART cookie by visiting the Google ad and content network privacy policy at http://www.google.com/privacy_ads.html
Access to Information
- We will endeavour to take all reasonable steps to keep secure any information which we hold about you, and to keep this information accurate and up to date. If, at any time, you discover that information held about you is incorrect, you may contact us using the details on our website, to have the information corrected.
- Registered users can access their information by logging into the website and viewing their account.
- Our employees and the contractors who provide services related to our information systems are obliged to respect the confidentiality of any personal information held by us.
Changes to this privacy policy
- We have the discretion to update this privacy policy at any time. We encourage users to frequently check this page for any changes to stay informed about how we are helping to protect the personal information we collect. You acknowledge and agree that it is your responsibility to review this privacy policy periodically and become aware of modifications.
Your acceptance of these terms
- By using this site, you signify your acceptance of this policy. If you do not agree to this policy, please do not use our site. Your continued use of the site following the posting of changes to this policy will be deemed your acceptance of those changes.
Problems or questions
- If we become aware of any ongoing concerns or problems with our web sites, we will take these issues seriously and work to address these concerns. If you have any further queries relating to our Privacy Policy, or you have a problem or complaint, please contact us at:
Email: [email protected]
- For more information about privacy issues in Australia and protecting your privacy, visit the Australian Federal Privacy Commissioner's web site: http://www.privacy.gov.au/.


text:
Well hello there! Again!
Much like last year, I find myself in the predicament of having some 2017 Calendars left over past the New Year - and by some I mean a lot!
So! What that means to the five people who still read this is that there are a few more chances this week to snag 2017 Calendar Girls. Hooray!
I'm going to be releasing them again in batches - about 25-30 calendars per batch over the course of a few days. The listings will be posted in my shop right here, and the release schedule will be as follows:
February Calendar Girl Release Schedule
Sunday, February 26th at 5pm PST
Monday, February 27th at 9am PST
Monday, February 27th at 9am PST
Monday, February 27h at 9pm PST
Tuesday, February 28th at 12pm PST
Wednesday, March 1st at 2pm PST
For those of you who may be new to this site or to buying calendars, I recommend taking a look at this post
for some troubleshooting tips! The price for this new batch of
calendars will be reduced to $75 each, and all girls include the full
deck of 2017 calendar pages.
Thanks so much for checking in on this little space! Hopefully I will be back soon with some non-calendar updates! Ta ta for now!


text:
[HD Moore] recently posted an article on Rapid 7's blog about an interesting security problem. They've been doing some research into the security of automated tank gauges (ATGs). These devices are used at gas stations and perform various functions including monitoring fuel levels, tracking deliveries, or raising alarms. [Moore] says that ATGs are used at nearly every fueling station in the United States, but they are also used internationally. It turns out these things are often not secured properly.
Many ATG's have a built-in serial port for programming and monitoring. Some systems also have a TCP/IP card, or even a serial to TCP/IP adapter. These cards allow technicians to monitor the system remotely. The most common TCP port used in these systems is port 10001. Some of these systems have the ability to be password protected, but Rapid 7's findings indicate that many of them are left wide open.
The vulnerability was initial reported to Rapid 7 by [Jack Chadowitz]. He discovered the problem due to his work within the industry and developed his own web portal to help people test their own systems. [Jack] approached Rapid 7 for assistance in investigating the issue on a much larger scale.
Rapid 7 then scanned every IPv4 address looking for systems with an open port 10001. Each live system discovered was then sent a "Get In-Tank Inventory Report" request. Any system vulnerable to attack would respond with the station name, address, number of tanks, and fuel types. The scan found approximately 5,800 systems online with no password set. Over 5,300 of these stations are in the United States.
Rapid 7 believes that attackers may be able to perform such functions as to reconfigure alarm thresholds, reset the system, or otherwise disrupt operation of the fuel tank. An attacker might be able to simulate false conditions that would shut down the fuel tank, making it unavailable for use. Rapid 7 does not believe this vulnerability is actively being exploited in the wild, but they caution that it would be difficult to tell the difference between an attack and a system failure. They recommend companies hide their systems behind a VPN for an additional layer of security.
[Thanks Ellery]


text:
The Secret World: still sucking us in six months on
Six months, five content updates and one less subscription fee later, The Secret World has finally gelled for our resident MMO newbie, Brenna.
It started so innocently one afternoon. "Help me do a few of the last quests in Kingsmouth; they're too hard for me to solo." Then it was 0200 and we'd smashed our way through two zones and were ready to hit up a third.
The Secret World really upset me when it launched last year, filled with wondrous lore, but as impenetrable as Aunty Hilda's year-old fruit cake and buggy enough to make spiders slaver. "I want to love it," Pat told me recently. Me, too - so much so that I wrote to Joel Bylos and demanded answers. Unfortunately his sane and considered response was not enough to keep me forfeiting my subscription to pay for removalists.
Now the MMO has gone if not free-to-play than subscription free, adopting a Guild Wars approach with a one-time cover charge, and I have a new housemate with more quests under his belt than I ever knew existed. It's time to back to Kingsmouth, the zombie and Draugr-infested New England town which is the landing zone for Solomon Island.
It started so innocently one afternoon. "Help me do a few of the last quests in Kingsmouth; they're too hard for me to solo." Then it was 0200 and we'd smashed our way through two zones and were ready to hit up a third.
It turns out going back to redo older quests can be pretty rewarding, especially if you're in a group and can speed through. My housemate was earning reasonable experience and more importantly ability points and skill points, handed out with lavish abandon as quests are completed, which in this level-free game are how you count your progress.
It's an odd sort of progress, though. The gigantic number in the middle of your ability wheel, which shows how far along you are towards achieving everything, doesn't really mean much. A much less progressed character with a clever build adapted fot the situation has a better chance of success - and survival.
Impromptu dance party, everyone is invited.
The build I favour at the moment uses blood magic (one of nine primary ability trees) exclusively, because I've been stacking all my points in that tree on my way to unlocking a deck (collection of synergistic skills which earns you a special uniform reward).
I don't have any mind-blowingly good gear but what I do have is a variety of active and passive skills I've chosen to keep me alive and wear down the enemy. If I get caught in a battle beyond my current capacities I grit my teeth, fire off a few damage-over-time sbilitieswhich I've teamed up with some nasty status effects, and heal myself until all the other cooldown timers vanish. Rinse and repeat; everything gives up in the end.
This is not a tremendously exciting way to play, and when I have my housemate to tank I switch to spike damage or multi-target skills, but the point is: it works. No, the point is: I put it together myself.
The Secret World's decks are nice targets to aim for, representing solid builds designed for various group roles or soloing, and it's particularly nice that a range of low-level decks have been added since I last played, giving new players an achievable goal. But the real fun comes in just putting the pieces together.
This took me a long time to figure out because I kept dying so much on my own, and playing with Pat - both of us equally befuddled, for The Secret World, bless it, is simply terrible at explaining itself to players - was not much better. Just reading the skill descriptions isn't enough. You need to see them in action, think about them, and start scanning ahead for way to multiply them - something that doesn't feel easy until you've got one or two more effective high level skills to play with.
Grouping up with my housemate, who smashes through low-level bosses and shouts "thanks for showing up" into the mic as they fall to his elemental and blade combo, gave me the time and space I needed to start experimenting and thinking for myself. Now I'm clever enough and strong enough to solo the early zones; I'm looking forward to more challenging areas where even my fearless housemate minds his aggro; and I'd dearly love to revisit some places I've been with a new player or two, so I can be the monster smashing the boss's face in and showing off just how cool The Secret World is.
The Secret World has come a long way since launch, despite two rounds of lay-offs, and new features and content are being added all the time. It still has some problems, notably in the user interface and inventory, but the buggy quests and weird glitches of launch week are now infrequent enough to be surprising.
More importantly though, I've also come a long way: from not knowing a thing about MMOs besides a few buzz terms common to party RPGs (holy trinity, aggro) to chatting with my housemate about my plans to carry two sets of gear specced for different group roles as well as my solo setup. I understand crafting; I've unlocked a faster sprint; I have strong opinions about various enemies and quests. I still can't reliably use the chat window.
I've been told that The Secret World is an MMO for people who love MMOs. It doesn't hold your hand explaining basic MMO tropes (then again, it also doesn't bother explaining its own unique features, either). It ramps up the difficulty sooner rather than later. It offers good rewards for replaying existing content, and it never locks you into any particular role; there are no respecs when you can unlock a good slice of a new tree in a few hours of questing.
But for me, The Secret World is the MMO I play even though I'm not into MMOs.
The Secret World has noted a 400% increase in activity since dropping its subscription requirement.


text:
If you've ever worked in a managerial role at a tech company, chances are you've been bombarded with spam from recruiters. The market for tech workers is so tight right now that employers are desperate for new talent. They're paying huge amounts, and recruiters bombard anyone with a job with offers to move elsewhere.
For one startup, the problem became so irritating and persistent that its founder came up with a solution.
Darren Nix, founder at the commercial real estate search engine for tenants 42Floors, has invented a "black hole" for spammy recruiters.
The concept is simple. When an unsolicited recruiter persists, whomever is being contacted would tell that recruiter to contact "a very patient individual" named Derrick in the human resources department at 415-534-6560.
Derrick would then proceed to share job requirements in excruciating detail from five random jobs listed in Indeed.
The catch, however, is that Derrick isn't actually human.
"You would swear it's a real individual," Nix said to Business Insider.
The 38-minute recording explains the details for five jobs listed on Indeed over the span of 11 minutes. He then starts again from the beginning and covers the jobs he already mentioned.
Nix said he came up with the idea after recruiters continuously bugged him and his coworkers at 42Floors multiple times a day.
"Occasionally, you get these bad actors who can't get through the gates so to speak," Nix said. "So they try to get around the back and try to contact others directly by guessing their email addresses."
Here's an example of the types of emails employees at 42Floors receive on a daily basis, as Nix posted to the company's blog:
That's not to say 42Floors is against using recruiters. In his blog post detailing the "black hole," Nix specifies that there are great recruiters out there who have helped the company gain some key hires. 42Floors hires recruiting firms and has a long list of reliable firms that have already been vetted.
When 42Floors wants to work with a recruiter, the company typically reaches out to these sources. But recruiting agencies that try to track down members of the 42Floors team typically present resumes for candidates that aren't qualified for the advertised position — in turn their wasting time.
Nix referred to these types of recruiters as "spray and pray" companies, meaning they bombard managers with a bunch potential hires without verifying that they're the right person for the job. They then hope that one of these candidates gets hired.
After a company hires a candidate selected by a recruiter, that recruiter typically gets compensated 20% of the hire's first-year salary, Nix said. He cautioned, however, that this is just based on his understanding and may not reflect the standard practice of all recruiting firms.
42Floors has been using this "black hole system" for several days, and Nix said he's pleased with the results so far.
"It's working," he said. "They never call back."


text:
We've heard about the digital divide involving education and children during the pandemic, but there's another group also experiencing a communications gap. However, a nonprofit group that works to support LGBTQ elders says the divide and isolation in the community were made worse over the past year and a half.
Bill Meehan says the pandemic was a roller coaster that has seemingly no end.
"We found that doing a lot of stuff on Zoom was really good except that many people didn't have the ability to go on Zoom because of lack of equipment or no connectivity," Meehan said.
Meehan hasn't had trouble with connectivity, but he knows plenty of people within his community who have.
"Those that are without social networks. One of my neighbors is legally blind and speaks limited English. She has a son that visits once a week, but she has two birds and that's her universe right now," Meehan said.
SAGE, the world's largest and oldest organization that's dedicated to improving the lives of LGBTQ elders, is trying to lessen the digital divide.
"If they're a person of color and of trans experience, how are they navigating through this complexity of social services? It's very complicated and oftentimes access to the internet is a lifesaver for so many folks," said Dr. David Vincent, chief program officer for SAGE. "LGBT older people are less likely to be partnered or have children, so 3 in 4 LGBT older people are concerned about not having enough support from their families or friends, four times less likely to have children, and two times as likely to be single and living alone."
Dr. Vincent says lately they've joined forces with the Diverse Elders Coalition. The group of five agencies put a proposal together to collectively call on Congress to fight the disparities faced by older adults from racially and ethnically diverse backgrounds, in addition to LGBTQ+ communities.
"Which is really about connecting people providing case management, providing technical assistance to aging providers, in order to best serve them," explained Dr. Vincent. "Providing connection through cyber education and developing virtual programming."
As for Bill Meehan, he's excited about the SAGE center that just opened in his building. He's started a book club and he's working within his LGBTQ community to alert people about the dangers of isolation.
"There's 15 computers, so there will be opportunities for people who don't have connectivity who don't have computers in the building to go there and use the computer, and there will be classes on how to use the computer because for some people this will be the first introduction to electronic communications," Meehan said.


text:
The current issue of Irish Roots magazine (2010 number 4) contains an excellent article by Henry Cruise describing the genealogical resources he used to research the history of his Cruise family in Ireland. The article is the first in a three-part series and is an edited version of a project he submitted for a Diploma in Genealogy awarded by Independent Colleges in conjunction with the Association of Professional Genealogists in Ireland. The first part of the article focuses on Henry's grandparents, William Alexander Raleigh Cruise and Tempy Adye-Curran, who lived at a variety of addresses in Dublin and had thirteen children. William was born in 1878 in Drumhirk, County Monaghan, and was the son of Richard Joseph Cruise and Elizabeth Francesca Raleigh. The article can be seen online on the Irish Roots website by clicking on "Inside" on the cover of the magazine and scrolling through the pages. Irish Roots is only available in digital format and a subscription is required to receive the full journal. I shall look forward to reading the second article in the series in due course.
© Debbie Kennett 2011


text:
YOU are responsible !!
It is a statutory requirement and many insurance companies require the insured to comply
with all current regulations. This includes the Electricity at Work Regulations 1989,
which state that "As may be necessary to prevent danger, all systems shall be maintained
so as to prevent, so far as reasonably practicable, such danger" (Regulation 4(2)).
"Electrical equipment includes anything used, intended to be used or installed for use,
to generate, provide, transmit, transform, rectify, convert, conduct, distribute, control,
store, measure or use electrical energy." (Regulation 2(1)).
The responsibility on the employer to ensure work equipment is safe is also covered by The Provision and Use of Work Equipment Regulations 1998. This states that "Every employer shall ensure that work equipment is so constructed or adapted as to be suitable for the purpose for which it is used or provided." (Regulation 4(1)). This includes all work equipment (fixed, portable or transportable) connected to a source of electrical energy."
Failure to comply with Electrical Regulations can lead to a maximum penalty of a £5,000 fine and/or up to six months imprisonment. For breaches under the general duties of the Health Safety at Work Act 1974, penalties of up to £20,000 were introduced in 1992 and offences heard on indictment in the Crown Court attract unlimited financial penalties and up to two years imprisonment
It's not worth the risk ! Call us now to a FREE no obligation quotation. It's cheaper than you think.
Further information can be found by clicking here and visiting the IEE
© 2010-2012 PatTestEast.co.uk - part of NVPC Ltd


text:
By using Apprenticeforums services you agree to our Cookies Use and Data Transfer outside the EU. We and our partners operate globally and use cookies, including for analytics, personalisation, ads and Newsletters.
Helping business owners with every day advice, tips and discussions with likeminded business owners. Become apart of a community surrounded by level headed business folk from around the UK