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Your local dealer will get back to you within 24 hours with recommendations and to book an appointment.
Being able to count on the safety and reliability of your Subaru is one of the very best features of owning it. However, performing a routine Subaru maintenance schedule is critical if you want your vehicle to last a lifetime. At TIRECRAFT, we can prevent minor issues from turning into big problems through regularly scheduled maintenance.
TIRECRAFT offers you a top notch service department to provide your vehicle with the best care. Some of the services offered by us are:
Vehicle oil keeps the pistons from creating friction, which raises your engine's temperature and makes it harder to work. So, it is important to change the oil regularly.
At TIRECRAFT, we provide Subaru oil services such as –
You have options when it comes to oil changes. We offer you Conventional oil, semi-synthetic oil and full-synthetic oil. Our certified technicians can help you to determine which type of oil is best for your Subaru.
Your tires are an important part of your vehicle, but if you avoid services such as putting off tire rotations, some unwanted even patches appear on certain areas, which produces weakness in the wall of your tire. TIRECRAFT gives tires services like tire rotations which keep the tire pressure constant and makes your tire life longer. Some other tire services are –
Regularly checking your brakes improves the performance of your vehicle. It is always best to get your brakes checked at least once a year to ensure they keep you safe on the road and do not end up costing you more. TIRECRAFT brake services include –
A failing battery can lead to many issues. So we make sure that your car's battery is in prime condition to last longer. At TIRECRAFT, we install new batteries of well-known brands that provide your car a new life. A battery change service is important, and thus we can help you pick the right battery for your vehicle. We'll remove your old batter, recycle it, and install your new battery to ensure you have peace of mind the next time you go to turn the key.
If you live in Canada, you know how chilly winters are here. Keeping your windshield clear of snow or rain is important to make sure you see clearly. Old wiper blades leave streaks on windshields and can crack or bend. Bring your Subaru to TIRECRAFT, where we'll swap your old blades so that you get clear visibility.
If your vehicle is drifting or pulling to one side or your one-side tire is more worn out than the other. Then, it is highly advisable to get a wheel alignment. Be it tire rotation, tire replacement or wheel alignment, TIRECRAFT uses computerized wheel alignment and tire rotation and balancing machines to get your vehicle back on track in no time. Some of our locations also check the steering angle sensor that senses where you are holding the steering wheel in relation to the wheels. The sensor works with the stability control systems and should be reset after a wheel alignment.
Preventative services will extend the lifespan of your vehicle and will save you money and maybe even your life. Bring your vehicle to your nearby TIRECRAFT, where our skilled and professional technicians will sort out any issues that might be coming or which you have not yet noticed. Our preventive maintenance services include –
At TIRECRAFT, we are committed to giving our customers satisfaction with our professionals and excellent services. As a TIRECRAFT customer, your Subaru tire purchase or mechanical service is backed by our "TIRECRAFT Advantage Plus" program.
We offer you –
For getting the best services for smoother operations, schedule your Subaru service today at TIRECRAFT. Our certified technicians can perform any maintenance services that will help you to give your Subaru a smooth, safe and comfortable ride.


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Steelcase and Microsoft announce development of technology-enabled spaces designed to boost creative work
Companies introduce Creative Spaces, new research and Surface Hub reseller program.
GRAND RAPIDS, Mich. and REDMOND, Wash. – March 6, 2017 – Steelcase and Microsoft Corp. have joined forces to explore the future of work, developing a range of technology- enabled spaces designed to help organizations foster creative thinking and better collaboration. These spaces seamlessly integrate the best of Microsoft Surface devices with Steelcase architecture and furniture. Today the companies unveiled five new "Creative Spaces" showcasing how Steelcase and Microsoft can help organizations unlock creativity for every employee.
Additionally, Steelcase and Microsoft announced:
- That Microsoft is expanding its partner network into the world of design by bringing in select Steelcase dealers as authorized Surface Hub resellers.
- Steelcase and Microsoft are working together to develop technology-enabled workplace solutions built on Microsoft Azure IoT technology.
"The problems people face at work today are much more complex than they used to be. They require a new creative way of thinking and a very different work process," says Sara Armbruster, vice president of strategy, research and new business innovation for Steelcase. "We believe that everyone has the capacity for creative thinking, and people are happier doing creative, productive work. Together, Microsoft and Steelcase will help organizations thoughtfully integrate place and technology to encourage creative behaviors at work."
The Problem: Fostering Creativity as a Business Advantage
According to joint research conducted by Steelcase and Microsoft, creativity is seen as a critical job skill driven by organizations' need for innovation and growth in addition to employees' desire for meaningful work. However, today many organizations invest in technology and space as separate entities rather than approaching them holistically. The lack of cohesion creates sub-optimal conditions for fostering creativity at work.
The research released today (of 515 US and Canadian companies with 100+ employees)[i] reveals the pressure people feel about the shift toward more creative work:
- Seventy-two percent of workers from diverse fields including Health Care, Retail, Education, Financial Services and Manufacturing believe their future success depends on their ability to be creative.
- Seventy-six percent believe emerging technologies will change their jobs, requiring more creative skills as routine work becomes automated.
- There is greater need to collaborate in business, yet only 25 percent of respondents feel they can be creative in the places they currently have available for group work.
- The study also reveals the connection between creativity and privacy, as employees ranked having a place to work without disruption as the second highest factor that could improve creativity, just behind the need for more time to think.
Creative Spaces
The companies' exploration of creative work found that creativity is a process in which anyone can engage and requires diverse work modes as well as different types of technology. People need to work alone, in pairs and in different size groups throughout a creative process, and they need a range of devices that are mobile and integrated into the physical workplace. Additionally, spaces should inspire people without compromising performance.
"Every Microsoft Surface device strives to enable the creator in each of us. Devices like Surface Studio and Surface Hub are fundamentally designed around how people naturally create, connect, and collaborate," says Ryan Gavin, general manager, Microsoft Surface Marketing. "With Steelcase we have the compelling opportunity to blend place and technology into a seamless environment that allows our most important asset, our people, to unlock their creativity and share that with others. The future of work is creative."
"Most employees are still working with outdated technology and in places that are rooted in the past, which makes it difficult for them to work in new, creative ways," said Bob O'Donnell, president, founder and chief analyst at TECHnalysis Research. "Creative Spaces were clearly designed to bridge the current gap between place and technology and to help creative work happen more naturally."
Five initial Creative Spaces are on display now at the Steelcase WorkLife Center in New York City. Spaces include:
- Focus Studio: Individual creative work requires alone time to focus and get into flow, while also allowing quick shifts to two-person collaboration. This is a place to let ideas incubate before sharing them with a large group, perfect for focused work with Microsoft Surface Book or Surface Pro 4.
- Duo Studio: Working in pairs is an essential behavior of creativity. This space enables two people to co-create shoulder-to-shoulder, while also supporting individual work with Microsoft Surface Studio. It includes a lounge area to invite others in for a quick creative review with Surface Hub or to put your feet up and get away without going away.
- Ideation Hub: A high-tech destination that encourages active participation and equal opportunity to contribute as people co-create, refine and share ideas with co-located or distributed teammates on Microsoft Surface Hub.
- Maker Commons: Socializing ideas and rapid prototyping are essential parts of creativity. This space is designed to encourage quick switching between conversation, experimentation and concentration, ideal for a mix of Surface devices, such as Surface Hub and Surface Book.
- Respite Room: Creative work requires many brain states, including the need to balance active group work with solitude and individual think time. This truly private room allows relaxed postures to support diffused attention.
"We are facing a time of unprecedented change at work. Through this partnership we will bring together space and technology to help workers and organizations solve the workplace challenges they face today and in the future and ultimately perform their best at work," explains Armbruster.
Steelcase: Microsoft Surface Hub Reseller
Select Steelcase dealers are authorized to resell Microsoft Surface Hub as a part of the Microsoft partner network beginning today in the United States and Canada, and in later Summer 2017 additional dealers in Germany and the United Kingdom are expected to be added to the program. The companies will announce additional markets in the coming months. As the spaces roll out in the Americas, Europe and Asia Pacific, the range of spaces will continue to expand and evolve.
Internet of Things
In the coming months, Steelcase expects to announce new technology-enabled office solutions built on Microsoft Azure IoT technology, which will provide companies with analytics that help improve workplaces and solutions to help employees find the best places to do diverse types of work within the office.
For more information on Creative Spaces and the partnership between Microsoft and Steelcase, visit www.steelcase.com/creativity or www.microsoft.com/en-us/devices/business/steelcase.
About Microsoft
Microsoft (Nasdaq "MSFT" @Microsoft) is the leading platform and productivity company for the mobile-first, cloud-first world, and its mission is to empower every person and every organization on the planet to achieve more.
About Steelcase Inc.
For over 100 years, Steelcase Inc. has helped create great experiences for the world's leading organizations. We demonstrate this through our family of brands – including Steelcase®, Coalesse®, Designtex® PolyVision® and Turnstone®. Together, they offer a comprehensive portfolio of architecture, furniture and technology products and services designed to unlock human promise and support social, economic and environmental sustainability. The company is globally accessible through a network of channels, including over 800 dealer locations. Steelcase is a global, industry-leading and publicly traded company with fiscal 2016 revenue of $3.1 billion.
SOURCE: Microsoft

subset: commoncrawl


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OR WAIT null SECS
© 2024 MJH Life Sciences™ and BioPharm International. All rights reserved.
Europe prepares for inclusion of Croatia in EMA activities.
Croatia joined the European Union on July 1, 2013 and, therefore, became part of the European Medicines Network. The country will now be involved in European Medicines Agency (EMA) activities. Europe began preparing for Croatia's participation in 2007 with the creation of the Instrument for Pre-accession Assistance (IPA) program and with ongoing work with Croatian authorities. Croatia participated in selected EMA meetings as part of the IPA program.
EMA and Croatia also started a pre-accession linguistic review of product information in January 2011 to facilitate "the phasing-in of European Commission decisions on centrally authorised medicines once Croatia joined the EU thereby avoiding delays in the supply of medicines in Croatia." EMA has issued revised guidance that outlines the phasing-in of authorized products in Croatia and operational aspects.
Related Content:


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Cisco Office Halifax
3D datacomm is a professional audio visual integrator offering video collaboration solutions for businesses, governmental offices and educational facilities in New Brunswick (NB), Nova Scotia (NS), Newfoundland (NF), Prince Edward Island (PEI) and Labrador. We began our business in audio visual sales in 1998. Now, we continue to develop a strong reputation for creating state-of-the-art audio visual integration systems that allow efficient business communication.
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Personalized AV solutions for a wide range of industries, including businesses in both the public and private sector. Whether you need to optimize one room or an entire building, we can handle the project. Reach out to 3D datacomm today for a consultation.


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Larry Sanger
Joined 15 October 2015
See also my Wikipedia page.
Below I'll include links to things that should be on the metadiscussion wiki rather than on the main wiki. In particular, here are a few columns mainly on Wikipedia- and general 'pedia-related subjects:
- Columns in 30 minutes or less (June 8)
- Why a list of the senses of a word is not an encyclopedia article (June 10)
- Why I am suspicious of subpages (June 12)
- Accidental linking and hard-wired category schemes (June 14)
- Disambiguating parentheses (June 15)
- Peer review and the Wikipedia process (June 25)
- Estimating article numbers (June 28)
- The Perfect Stub Article (July 1)
- The case against subpages (July 1)
- List-o-links (July 5)
- Introducing the Nupedia Chalkboard (July 19)
- Britannica or Nupedia? The Future of Free Encyclopedias (Kuro5hin; July 25)
- An impending scalability problem (August 13)
- Some standards of excellence (August 28)
- Wikipedia as a first home for other wiki projects (August 31)
- What is an encyclopedia? (September 1)
- What Talk pages are not for (September 10)
- How to revise the policy pages (September 17)
- The epistemology of Wikipedia (September 19)
- Wikipedia is wide open. Why is it growing so fast? Why isn't it full of nonsense? (Kuro5hin; September 24)
- The art of Wikipedia weeding (September 26)
- Cutting each other a bit of slack (October 18)
- Open Content Encyclopedias in Education (Open Source Schools; October 20)
- Is Wikipedia an experiment in anarchy? (November 1)
- Moving commentary out of Wikipedia (November 2)
- Common words made into URLs (November 16)
- How a giant free encyclopedia might transform learning (Open Source Schools; November 18)
- Almanac-type information (November 21)
- Deferring to the experts (January 3, 2002)
- Wikipedia and why it matters (January 16, 2002) (Talk given at Stanford; see [1] to view the talk, including a Q&A that isn't transcribed here)
- Announcement about my involvement in Wikipedia and Nupedia (February 13, 2002)
- My resignation (March 1, 2002)
Please be aware that these are comments about Wikipedia, an encyclopedia project, rather than about WikiWikis in general. Indeed, the comments I make here might not hold at all for WikiWikis in general.


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At least 66 arrested for selling horse meat 'unfit for human consumption'
BRUSSELS (AP) -- Authorities have arrested at least 66 people in a European food scam which sold horse meat unfit for human consumption.
European Union police coordinating organization Europol announced Sunday that eight nations cooperated in the operation. In Spain, 65 people face a series of charges relating to public health, money laundering and animal abuse.
The operation took several months and the chief suspect, a Dutch businessman, was arrested in Belgium in April.
Spain's Civil Guard said that the criminal ring acquired horses in Spain and Portugal that were "in poor shape, old, or had been designated `not apt for consumption."' After falsifying paperwork and substituting microchips used to identify the horses, the animals were slaughtered and the meat shipped to Belgium.
The Civil Guard said that the profits from the illegal meat could reach 20 million euros ($23 million) a year.
The case was linked to a 2013 scandal when Irish authorities detected beef burgers containing horse meat.
Authorities in Belgium, France, Italy, Portugal, Romania, Switzerland, Britain and Spain cooperated in the operation.


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Luxury Soft Plain Satin Silk Pillowcases in Set of 2 - Vanilla Ice
Luxury Soft Plain Satin Silk Pillowcases in Set of 2 - Vanilla Ice
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Material: Silk Satin
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Shipping and Return
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This is an important item that properly updates us on the present
reality of scientific thought of the topic of inheritance. It has
been clear to me for a number of years that parents change the
genetic outcome of their offspring somehow other that natural
selection which has been the prevailing dogma. I speculated as to
means and all that.
At the same time, the field itself was coming to the same conclusion
and the name of Lamarck is even mentioned here quite honorably.
This now shows us experiments that confirm the hypothesis and the
necessary pathways are now been winkled out. It turns out that way
more information is transmitted on conception than the core DNA. It
is an astonishing idea and powerfully reinforces the core role of
fathers generally that has been challenged in the past two
It is worth a slow reflective reading and it is also sobering. Our
society has conducted an experiment over the past two generations
that needs to fully rethought and plausibly reformed.
Why Fathers Really
Paul Blow
By JUDITH
MOTHERHOOD begins as a
tempestuously physical experience but quickly becomes a political
one. Once a woman's pregnancy goes public, the storm
moves outside. Don't pile on the pounds! Your child will be obese.
Don't eat too little, or your baby will be born too small. For
heaven's sake, don't drink alcohol. Oh, please: you can sip some
wine now and again. And no matter how many contradictory things the
experts say, don't panic. Stress hormones wreak havoc on a baby's
budding nervous system.
All this advice rains
down on expectant mothers for the obvious reason that mothers carry
babies and create the environments in which they grow. What if it
turned out, though, that expectant fathers molded babies, too, and
not just by way of genes?
Biology is making it
clearer by the day that a man's health and well-being have a
measurable impact on his future children's health and happiness.
This is not because a strong, resilient man has a greater likelihood
of being a fabulous dad — or not only for that reason — or
because he's probably got good genes. Whether a man's genes are
good or bad (and whatever "good" and "bad" mean in this
context), his children's bodies and minds will reflect lifestyle
choices he has made over the years, even if he made those choices
long before he ever imagined himself strapping on a Baby Bjorn.
Doctors have been
telling men for years that smoking, drinking and recreational drugs
can lower the quality of their sperm. What doctors should probably
add is that the health of unborn children can be affected by what and
how much men eat; the toxins they absorb; the traumas they endure;
their poverty or powerlessness; and their age at the time of
conception. In other words, what a man needs to know is that his life
experience leaves biological traces on his children. Even more
astonishingly, those children may pass those traces along to their
Before I began reading
up on fathers and their influence on future generations, I had a
high-school-biology-level understanding of how a man passes his
traits on to his child. His sperm and the mother's egg smash into
each other, his sperm tosses in one set of chromosomes, the egg
tosses in another, and a child's genetic future is set for life.
Physical features: check. Character: check. Cognitive style: check.
But the pathways of inheritance, I've learned, are subtler and more
varied than that. Genes matter, and culture matters, and how fathers
behave matters, too.
Lately scientists have
become obsessed with a means of inheritance that isn't genetic but
isn't nongenetic either. It's epigenetic. "Epi," in
Greek, means "above" or "beyond." Think of epigenetics as the
way our bodies modify their genetic makeup. Epigenetics describes how
genes are turned on or off, in part through compounds that hitch on
top of DNA — or else jump off it — determining whether it makes
the proteins that tell our bodies what to do.
In the past decade or
so, the study of epigenetics has become so popular it's practically
a fad. Psychologists and sociologists particularly like it because
gene expression or suppression is to some degree dictated by the
environment and plays at least as large a role as genes do in the
development of a person's temperament, body shape and
predisposition to disease. I've become obsessed with epigenetics
because it strikes me as both game-changing and terrifying. Our genes
can be switched on or off by three environmental factors, among other
things: what we ingest (food, drink, air, toxins); what we experience
(stress, trauma); and how long we live.
Epigenetics means that
our physical and mental tendencies were not set in stone during the
Pleistocene age, as evolutionary psychology sometimes seems
to claim. Rather, they're shaped by the life we lead and the world
we live in right now. Epigenetics proves that we are the products of
history, public as well as private, in parts of us that are so
intimately ours that few people ever imagined that history could
reach them. (One person who did imagine it is the French 18th-century
naturalist Jean-Baptiste Lamarck, who believed that acquired traits
could be inherited. Twentieth-century Darwinian genetics dismissed
Lamarckism as laughable, but because of epigenetics, Lamarckism
is staging a comeback.)
The best-known example
of the power of nutrition to affect the genes of fathers
and sons comes from a corner of northern Sweden called Overkalix.
Until the 20th century, Overkalix was cut off from the rest of the
world, unreachable by road, train or even, in wintertime, boat,
because the frozen Baltic Sea could not be crossed. Thus, when there
were bad harvests in Overkalix, the children starved, and when there
were good harvests, they stuffed themselves.
More than a decade
ago, three Swedish researchers dug up records from Overkalix going
back to 1799 in order to correlate its children's health data with
records of regional harvests and other documents showing when food
was and wasn't available. What the researchers learned was
extremely odd. They found that when boys ate badly during the years
right before puberty, between the ages of 9 and 12, their sons,
as adults, had lower than normal rates of heart disease. When boys
ate all too well during that period, their grandsons had higher rates
of diabetes.
When the
study appeared in 2002, a British geneticist published an
essay speculating that how much a boy ate in prepuberty could
permanently reprogram the epigenetic switches that would govern the
manufacture of sperm a few years later. And then, in a process so
intricate that no one agrees yet how it happens but probably has
something to do with the germline (the reproductive cells that are
handed down to children, and to children's children), those
reprogrammed switches are transferred to his sons and his sons'
A decade later, animal
studies confirm that a male mammal's nutritional past has a
surprisingly strong effect on his offspring. Male rats that are
starved before they're mated produce offspring with less blood
sugar and altered levels of corticosterone (which protects against
stress) and insulin-like growth factor 1 (which helps babies
Southeast Asian men
who chew betel nuts, a snack that contains a chemical affecting
metabolic functioning, are more likely to have children with weight
problems and heart disease. Animal studies have shown that the
effects of betel nut consumption by a male may extend to his
Environmental toxins
leave even more florid traces on grandchildren and
great-grandchildren. Vinclozin, a fungicide that used to be sprayed
all over America (it's less common now), is what's known as an
endocrine disrupter; it blocks the production oftestosterone. Male
rats whose mothers receive a fat dose of vinclozin late in their
pregnancy are highly likely to be born with defective testicles and
reduced fertility. These problems seem to reappear in up to four
generations of male rats after the mother is poisoned.
THAT food and poison
change us is not all that surprising, even if it is surprising how
far down the change goes. What is unexpected are the psychological
dimensions of epigenetics. To learn more about these, I visited the
Mount Sinai Medical Center laboratory of Dr. Eric Nestler, a
psychiatrist who did a discomfiting study on male mice and what he
calls "social defeat." His researchers put small normal field
mice in cages with big, nasty retired breeders, and let the big mice
attack the smaller mice for about five minutes a day. If a mean mouse
and a little mouse were pried apart by means of a screen, the
torturer would claw at the screen, trying to get at his victim. All
this subjected the field mouse to "a horrendous level of stress,"
Dr. Nestler told me. This process was repeated for 10 days, with a
different tormentor placed in each cage every day. By the time the
torture stopped, about two-thirds of the field mice exhibited
permanent and quantifiable symptoms of the mouse equivalents
of depression, anxiety and post-traumatic stress disorder.
The researchers then bred these unhappy mice with normal females.
When their pups grew up, they tended to overreact to social stress,
becoming so anxious and depressed that they wouldn't even drink
sugar water. They avoided other mice as much as they could.
Dr. Nestler is not
sure exactly how the mouse fathers' trauma communicates itself to
their offspring. It may be via sperm, or it may be through some more
complicated dance of nature and nurture that involves sperm but also
other factors. When instead of letting the "defeated" mice mate,
Dr. Nestler's researchers killed them, harvested their sperm and
impregnated the female mice through artificial means, the offspring
were largely normal. Perhaps the sperm was harvested at the wrong
stage in the process, says Dr. Nestler. Or maybe the female mouse
picked up some signal when she had sex with the dysfunctional male
mouse, some telltale pheromone or squeak, that made her body withhold
nutrition and care from his pups. Females have been known to not
invest in the spawn of non-optimal males, an outcome that makes
perfect evolutionary sense — why waste resources on a loser?
When it comes to the
epigenetics of aging, however, there is little question that the
chemical insults and social setbacks of everyday life distill
themselves in sperm. A woman is born with all the eggs she'll ever
carry. By the time a man turns 40, on the other hand, his gonad cells
will have divided 610 times to make spermatozoa. By the time he's
in his 50s, that number goes up to 840. Each time those cells copy
themselves, mistakes may appear in the DNA chain. Some researchers
now think that a percentage of those mistakes reflects not just
random mutations but experience-based epigenetic markings that
insinuate themselves from sperm to fetus and influence brain
development. Another theory holds that aging gonad cells are more
error-prone because the parts of the DNA that should have spotted and
repaired any mistakes have been epigenetically tamped down. In any
case, we now know that the children of older fathers show more signs
ofschizophrenia, autism and bipolar disorder than
children of younger ones.
In a meta-analysis of
a population study of more than a million people published last year,
Christina Hultman of the Karolinska Institute of Sweden concluded
that children of men older than 50 were 2.2 times as likely to have
autism as children of 29-year-olds, even after the study had factored
out mothers' ages and known risk factors for autism. By the time
the men passed 55, the risk doubled to 4.4 times that of
29-year-olds. Can the aging of the parent population explain the
apparent spike in autism cases? A study published last month in
Nature that used whole-genome sequencing on 78 Icelandic
families made the strongest case to date that as fathers age,
mutations in their sperm spike dramatically. Some of the mutations
found by the researchers in Reykjavik have been linked to autism and
schizophrenia in children.
In his Washington
Heights laboratory at the New York State Psychiatric Institute, Jay
Gingrich, a professor of psychobiology, compares the pups of young
male mice (3 months old or so) to those of old male mice (12 to 14
months old). The differences between the pups, he told me, weren't
"earth-shattering" — they weighed about the same and there
weren't big gaps in their early development. But discrepancies
appeared when the mice grew up. The adult offspring of the older
fathers had less adventuresome personalities; they also reacted to
loud noises in unusual ways that paralleled reactions evinced by
schizophrenics who heard similar sounds.
Still, Dr. Gingrich
said, "the differences were subtle" until he decided to pool the
data on their behavior and graph it on a bell curve. A "vast
majority" of the children of the older mice were "completely
normal," he said, which meant their score fell under the
upside-down parabola of the curve. The real differences came at the
tails or skinny ends of the bell curve. There was about a sixfold
increase in likelihood that one of the "abnormal outliers," mice
with cognitive or behavioral handicaps, "would come from an older
father." Conversely, the super-high-performing mice were about six
times more likely to come from a younger father. "I'm an
inherently skeptical person," Dr. Gingrich told me, but he was
impressed by these results.
One unanswered
question about autism and schizophrenia is how they crop up in
generation after generation; after all, wildly dysfunctional
individuals don't usually flourish romantically. "I think we're
going to have to consider that advanced paternal age, with its
epigenetic effects, may be a way of explaining the mysteries of
schizophrenia and autism, insofar as the rates of these disorders
have maintained themselves — and autism may be going up," Dr.
Gingrich said. "From a cruel Darwinian perspective, it's not
clear how much success these folks have at procreating, or how else
these genes maintain themselves in the population."
When you're an older
mother, you get used to the sidelong glances of sonogram technicians,
the extra battery of medical tests, the fear that your baby has Down
syndrome, the real or imagined hints from younger mothers that you're
having children so late because you care more about professional
advancement than family. But as the research on paternal inheritance
piles up, the needle of doubt may swing at least partway to fathers.
"We're living through a paradigm shift," said Dolores
Malaspina, a professor ofpsychiatry at New York University who
has done pioneering work on older fathers and schizophrenia. Older
mothers no longer need to shoulder all the blame: "It's the aging
man who damages the offspring."
Aging, though, is only
one of the vicissitudes of life that assault a man's reproductive
vitality. Think of epigenetics as having ushered in a new age of
sexual equality, in which both sexes have to worry about threats to
which women once felt uniquely exposed. Dr. Malaspina remembers that
before she went to medical school, she worked in a chemical plant
making radioactive drugs. The women who worked there came under
constant, invasive scrutiny, lest the toxic workplace contaminate
their eggs. But maybe, Dr. Malaspina points out, the plant managers
should have spared some concern for the men, whose germlines were
just as susceptible to poisoning as the women's, and maybe even
more so. The well-being of the children used to be the sole
responsibility of their mothers. Now fathers have to be held
accountable, too. Having twice endured the self-scrutiny and
second-guessing that goes along with being pregnant, I wish them


text:
How to Turn Off Scary iPhone Default Feature That Reveals Your Exact Location
Did you know that your iPhone automatically tracks your exact location and knows your patterns?
TikTok user @srh0e explained that iPhones track your whereabouts to the point that they create "significant locations." You may have already picked up on this when your phone suggests that it's X amount of minutes to get to home or where it says how far away you are from your parked car.
"This feature logs all of the places you've been, how long you've stayed and what time you left," he explained. So how does a person disable the default feature?
1. Click on your settings app
2. Scroll down and click on "privacy"
3. Select "location services"
4. Click on "system services"
5. Select "significant locations"
6. Click disable
On this screen, you can also view your own personal location data and see what locations it automatically created for you and even a log of the time you spent at each place.
"I just looked at mine. Home, dog park, Kroger. I need a life 😂" one commenter wrote.
While a good portion of TikTokers in the comments section were appalled and did not want their privacy being infringed upon, some believe that this is a good feature.
"I don't like it…but I watch too many true crime shows," one user wrote, another similarly added that if they go missing this is an excellent feature to utilize.
"Wish I had this information when I was married! Could [have] gotten divorced a lot sooner," a person joked.


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If your weekends are a mix of thrill and chill, the Smith Emerge has the range to keep up. With no-slip nose pads, these sunglasses stay put through runs and SUP sessions without the wraparound style of straight-up performance eyewear. The rectangular, bio-based frames are relaxed at the edges, giving them a refined shape that flatters most faces. They come with your choice of standard Carbonic lenses or Smith's color-boosting ChromaPop™ polarized lenses.
Product Details
- ChromaPop™ polarized lenses cut glare and enhance color and contrast
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Fit / Integration
- Medium fit, medium coverage
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Welcome to the Global Design Project #GDP099.
Thank you to all that played along with us last week for the sketch challenge last week. Make sure you go and check out all our other winners and special mentions from last week. Click here to see them!
Global Design Project Design Team
- Your creation must be NEW and reflect our project inspiration parameters
- LINK your entry DIRECTLY to the blog post or other gallery
- Please MENTION Global Design Project in your blog post and link back to us.
- When sharing publicly please use our hashtag #GDP099
- We reserve the right to remove any links that do not comply with our guidelines.
- Deadline for entries closes on Monday August 14, 2017 3:00pm AEDT. To view some of our time/dates in your region please see our Schedule.
Make sure you link to your direct blog post not just your blog and use the tag - #GDP099
Have fun and thanks so much for playing along!
The GDP Team xo
Add your projects here:
Add your projects here:


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The following death notices were received for Friday.
Joy Anna Beaver
Joy Anna Beaver, 88, of Bedford, died at 4:25am on Thursday, April 1st, 2010 at Core Nursing Home.
Born January 9th, 1922 in Prairie Creek, she was the daughter of Joy E. Pitman and Josephine Gobin. She married Bob Beaver on June 20th, 1950 and he preceded her in death.
Survivors include a sister, Norma; a son, David Robert Beaver and grandchildren. Joy Anna Beaver was preceded in death by her parents, husband and a sister.
Funeral services will be conducted at 10:00am on Monday, April 5th at the First Baptist Church, 877 East Popular Street, Terre Haute, IN. Burial will follow in Roselawn Cemetery in Terre Haute. Friends my call from 4:00pm to 7:00pm on Saturday, April 3rd at the Day & Carter Mortuary and from 9:00am until the hour of service on Monday, April 5th at the First Baptist Church in Terre Haute.
Ruth W. "Curley" Wray
Ruth W. "Curley" Wray, 87, of Mitchell, died at 5:50am Wednesday, March 31st, 2010, at White River Lodge in Bedford.
Born August 17th, 1922, in Martin County, she was the daughter of Ira E. and Malinda E. Webster. She married Ralph K. Wray January 8th, 1944, and he preceded her in death on August 26th, 1977.
Survivors include children, Robert, Suella, Eddie, Delbert and Joe; 16 grandchildren; 17 great grandchildren; 2 great great grandchildren; a sister; a sister in law and several nieces and nephews. Ruth W. "Curley" Wray was preceded in death by her parents, husband, great grandson, four sisters and five brothers.
Funeral services will be at 11:00am on Monday, April 5th, at Woodville Baptist Church with Rev. Glenn Hamer officiating. Burial will be in Mitchell Cemetary.
Friends may call from 3:00pm to 7:00pm Sunday at Chastain Funeral Home and from 10:00am until the service on Monday at the church.
Charles R. Sowders
Charles R. Sowders, 62, of Bedford, died at 1:50pm on Thursday, April 1st, 2010 at the Bedford Regional Medical Center.
Born April 26th, 1947 in Indianapolis, he was the son of Charles W. and Alice Irene Sowders. He married Susan Smith on September 19th, 1970 and she survives.
Survivors include his wife, Susan of Bedford; one son, Doug; one daughter, Kelly; three grandchildren; one brother, Dennis; three sisters, Susan, Pamela and Kimberly. He was preceded in death by his parents.
Funeral services will be conducted at 3:00pm on Monday, April 5th in the Elmwood Chapel of the Day & Carter Mortuary with Pastor Billy Brim officiating. Burial will follow in the Chapel Hill Cemetery with military rites accorded at the graveside. Friends may call from 4:00pm to 8:00pm on Sunday, April 4th at the Day & Carter Mortuary.
Ervin Parker
Ervin Parker, 78, of Bedford, died at 7:55pm on Thursday, April 1st, 2010 at Garden Villa in Bedford. Arrangements are pending at the Day & Carter Mortuary.


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If you're reading this right now, then you're probably going through a breakup. You're scouring the internet, looking for a way to convince your ex to change her mind and come running back to you.
I'm also guessing you're feeling exactly the same as every other guy who has ever gone through a breakup.... heartbroken, hopeless, and, at times, on the verge of an emotional breakdown.
And the thought of her with some other dude...? Well, in the wake of a breakup, that image can send even the toughest man to the brink of vomiting.
Listen, I know exactly what you're going through. I've been through my share of bad breakups.
BUT... today is your lucky day, because I've got great news for you...
Yes, you heard me.... you CAN get your ex back.
Not only can you get her back... but if you play your cards right and follow my advice, you'll be able to turn the tables completely.
She'll be the one BEGGING you to come back and give her another chance. She'll be the one texting YOU at 2am to tell you how badly she wants you... and calling you to explain how sorry she is that you two broke up.
Not only can you get her back into your arms, you can start fresh and rekindle that 'spark' the two of you had when you first kissed.
Does this all sound too good to be true? Fair enough, but trust me: I'm not making this up. It's been proven that more than 90% of all relationships can be salvaged... and yours is no different!
In fact, I'm so confident that I can teach you EXACTLY how to get your ex-girlfriend back -- to the point where she's literally banging on your door and won't leave you alone until you agree to take her back -- that I'm going to GUARANTEE IT. (More on this guarantee in a second...)
Even if she's already with some other dude.... or she's told you she doesn't love you anymore... you still have a VERY GOOD CHANCE of winning back her heart.
BUT... and this is a very important 'but'.... if you're serious about rebuilding your relationship and getting back together with your ex, you MUST read this article to the end.
And then you have to go out and APPLY the techniques and strategies I'm going to teach you in the next few minutes.
(If you think I'm full of crap and this is a waste of your time, feel free to close this window or click the "back" button... after all, it's probably better if my secret strategies don't get TOO well known! But if you're ready to get started on the the process of winning back your ex, then stick with me for another few minutes, and you'll be glad you did.)
Three things you absolutely must understand right off the bat:
FACT NUMBER ONE: In your current state - emotionally fragile, lonely, and possibly desperate - you're simply not in the right frame of mind to convince her that she needs you in her life. Chances are that anything you say or do right now to try and change her mind will only make matters worse!
(Don't worry, though: I'm going to show you exactly how to overcome this, and I'll walk you step-by-step through my tried & tested techniques.)
FACT NUMBER TWO: You're going to have to accept that your 'old' relationship is gone, and you can't have it back. And that's actually a good thing, because your 'old' relationship sucked anyway... after all, if your relationship was going well, then why did you guys break up?
Let me make it clear: I don't mean that you can't have your ex-girlfriend back.... I mean that you have to start a NEW relationship. A healthy one, free of cheating and lies and all the other things that led to your breakup in the first place.
FACT NUMBER THREE: In order to win back your ex-girlfriend and establish a new, healthy relationship, you need to erase all of the negative memories and thoughts she has of you... and replace them with positive ones. You need to tap in to her primal, subconscious feelings and plant the seeds of passion, romance, and sexuality so that she can't imagine herself with anyone else.
No worries, though... I've done the hard part already, and developed a step-by-step system of techniques that will quickly change her feelings about you... and, in no time at all, start re-building passion and romance.
Now, with those three important facts on the table, I guess I should introduce myself! My name is Brad Browning, and I'm a 'relationship geek'. I've worked with thousands of couples - and in particular, thousands of guys in the midst of a breakup - to fix broken relationships and build new ones that are oozing with passion and genuine love.
How did I figure out the recipe for success? How can I help 90% of all guys get back together with their ex? It took a few years of learning and testing, but I've managed to break down the female psychology to its core.... and learn exactly what 'makes women tick'.
I've identified the key buttons that men need to push in order to engage with a woman's hard-wired feelings and desires. These buttons are the key to your success.
Once you know which buttons to push, you just need to go out and push them... and that's why I built a comprehensive step-by-step guide to walk average men through the process of healing their broken relationships.
Listen, I'm not talking about the kind of "secrets" you'll hear about on late-night TV infomercials. I'm talking about real, proven techniques that I've tested and perfected over years of work with real men in real relationships.
These techniques work so well and so consistently because women are literally powerless to resist them. How can she resist if she has no idea you're even trying to get back together with her??
I'll teach you how to tap into a woman's primal instincts, fire up her sex drive, and mould the image of you that she has in the back of her mind.
Her panties will be dripping wet before you can say "snufalufagus."
... and the secret sauce to my program: I'll show you how to breeze straight past her 'warning systems' and natural urges to resist your advances (and how to ensure she ignores any annoying friends who keep telling her to stay away from you).
Now, this isn't rocket science... but what I can tell you for certain is that you definitely haven't read or heard much of the stuff I reveal in my program. Sure, maybe you've seen some of my tips regurgitated elsewhere on the internet, but most of it will be new to you. Here's a few examples:
Why employing my patented "3R" system (Recovery, Rekindling, and Reattraction) is absolutely critical to re-shaping her perception of you, making you the man she wants to grow old with
How you can get her thinking about you and longing for the "good old days" she enjoyed when you were together.... without even saying a word to her!
How the act of IGNORING her is actually a ridiculously effective way of re-building attraction (sound totally counter-intuitive? Yep, it is.)
Why the REKINDLING PHASE is quietly one of the most critical aspects of winning her back... and why almost all men have never even considered it
How you can use what I call "COVERT JEALOUSY" to make her forget about every other guy and start dreaming about YOU
Why the word "SORRY" should be completely erased from your vocabulary when you're talking to your ex
The CRUCIAL steps you MUST take when you've started to rebuild attraction and she inevitably begins to contact you again
How to re-ignite her feelings for you - even if she's already with another guy!
The one thing you absolutely cannot do for 30 days after you broke up (if you ignore this tip, you're toast!)
...and there's HUNDREDS of other practical, real-life techniques you'll want to apply RIGHT NOW if you're dead serious about building a new life with this girl by your side. What I've told you in this article is just the 'tip of the iceberg'.
At this point, you're probably well aware of how effective these techniques are... and you're probably wondering about the price. Don't worry, it's not going to cost you an arm and a leg.
But ask yourself... Do you really love this girl? Do you really want to get your ex back? Is she "the one"?
If the answer to those questions is "yes"... if this is the girl you want to be in that rocking chair beside you 50 years down the road... then it probably doesn't matter how much my program costs. Because you really can't let her get away, no matter how much it costs.
A few years from now, looking back, you might be willing to pay thousands of dollars for one more chance to get her back in your life.
There's nothing worse than constantly wondering "what if"... wondering if you could've done or said something that would've made her come running back to you, eager to spend a lifetime together.
Look, I know that despite everything I've said in this article so far, you may still be skeptical. Fair enough - there's a lot of garbage for sale on the internet these days.
But, do you remember early in this article, when I said that I'd guarantee my program would work for you? I guaranteed that by following my advice and applying my strategies, you'd be able to turn back time and return to the days when you and your ex were madly in love.
I wasn't kidding about that. Because I'm extremely confident that my program will work -- will provide you all the tools you need to rekindle that spark with your ex and show her what she's missing -- and I really want you to try it.
So, here's the deal: you sign up for my program, read it cover to cover, and apply the step-by-step strategies I've laid out. If, after reading the book and following my advice, she's somehow NOT begging for you to take her back.... if she's not ripping your clothes off and giving you the best sex of your life.... if your love isn't the strongest it's ever been....
Don't worry about rushing the process, either: you've got a full TWO MONTHS to apply my techniques and build a new life with your girl. (For a full 60 days after you sign up for my program, you can click your mouse a few times and get a 100% refund.)
Oh, and did I mention that the program also includes an audio book, video lessons, and two in-depth bonus manuals... all designed to make the process of getting your girl back into your bed simple, straightforward, and effective.
Now, let me ask you: if your ex walked up to you right now and said she'd be willing to get back together with you -- that you relationship would be stronger than ever -- but said it would cost you a bucket full of cash, how much would you be willing to fork over? $200? $500? $1,000? $10,000?!?!
Surely, if she's "the one," then you'd run to the nearest bank and withdraw your life savings, right?
Don't worry, I'm not going to ask for your life savings... hell, I'm not even going to ask you for $200.
Normally, the program sells for $129... and I've had hundreds of guys say that it was "worth every penny." But, like I said, I really want you to try the program and see for yourself how well it works... and I don't want the cost to prevent you from trying it out.
Several people said I was crazy to offer the program at $89... and I told them that was still too expensive for some guys.
Yes, that's a one-time payment of $47.00... in exchange for a proven system that's helped thousands of guys from around the world get exactly what they're looking for: a second chance with the girl of their dreams.
Remember: the 60-day money back guarantee means there's literally zero risk. Sign up, try it out, and I suspect you'll be extremely pleased with the results... just like the other thousands of guys who've used it successfully. But, in the case it doesn't work out, you just click a button and get your money back... no questions asked, no hassles, and no bullsh*t 'restocking fees'!
Now that I've taken away all the risk -- and offered you the program at the lowest price I can without going completely broke -- it's time for you to put aside the excuses and get going. Every second you wait on this is another second your ex could be falling for another man.
If you leave this website right now and say to yourself, "I'll think about it," that's fine... just be aware that the "window of opportunity" to get your ex back will only be open for so long. Eventually, she'll start to drift further and further away from you... you'll become a distant memory, replaced by some other dude. So if you're dead set on getting this girl back in your life, the time to act is now, not later.
When you enter your email address in the box below and click the signup button, you're about 2 minutes away from accessing the entire program... there are no physical products, which means you get instant access and can begin right now, even if it's 3am and you're sitting naked in the basement.
Thanks to Clickbank's payment processing system, I'll never see your credit card details. Your purchase will be secured using the most advanced encryption technology that money can buy. (That also means that if you're worried that I may not honor my 60-day money-back guarantee, ClickBank has your back and will always be there to process the refund.)
I don't think there's anything else I can say at this point to convince you that this program can and will work for you.... so maybe it's best if you hear it straight from a past customer. I got an email yesterday from a guy named Noah, who lives in Denmark. Noah says, "I don't usually send feedback when I buy something, but your program is definitely an exception. I learned a lot of important lessons that not only rebuilt the trust and love between me and my girlfriend but also made me a better lover. Many thanks!"
So even if the program is only half as effective for you as it was for Noah, isn't it still worth $47 to find out for yourself? Don't you owe it to yourself to at least give it a chance? If you don't, you'll truly never know what "could've been" if you'd forked over that 47 bucks.
Click the button below to sign up and get immediate access to the entire program. Don't worry, when you click the button, you'll see a summary of the program costs and what you'll be receiving for your $47... plus info on my 60-day money-back guarantee.
Oh, and thanks so much for stopping by my website today. I sincerely hope that this article and my program will give you everything you need to re-build a devoted, lasting relationship with the girl you love.
Best of luck - see you on the other side!
Yes! I want my Ex Factor Guide by Brad Browning which includes the book, audio, video and a slew of bonuses!
Yes, I also understand that if I'm not satisfied within 60 days of adding this exlusive package, I can e-mail Brad for a prompt refund. No questions asked!
I understand that this information will give me the best chance possible of getting my ex back.
I understand that my payment will be processed by ClickBank, the world's leading retailer for digital products. My purchase is 100% encrypted and secure.
Best regards,
Brad Browning
P.S. This is the best opportunity you'll ever get. My program has been applauded world wide. It works. But if you have any questions at all, feel free to e-mail me at [email protected]. I'll answer all of your questions.
P.P.S. Remember, you purchase is backed by ClickBank, the world's leading retailer for electronic products. If you are not satisfied with The Ex Factor Guide in any way, then you can just e-mail us for a quick, no-questions-asked refund within 60 days.
P.P.P.S. There's no better time than right now. The sooner you act, the better chance you'll have of going back in time and fixing things permanently with your ex. I can't put this any other way.


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The Pediatric Diagnostic Program is a comprehensive service of Boston Children's Hospital designed to diagnose and treat children and adolescents with complex symptoms or uncertain conditions.
Our team of experienced pediatricians, nurses, and behavioral health clinicians takes a holistic approach to care. We conduct in-depth assessments and provide support to patients, families, and referring clinicians. In an effort to provide the best and most comprehensive diagnosis, we work closely with experts from a variety of departments throughout Boston Children's including:
- Neurology
- Gastroenterology, Hepatology and Nutrition
- Cardiology
- Infectious Diseases
- Adolescent/Young Adult Medicine
- Psychiatry and Behavioral Sciences
- Pain Treatment Center
- Genetics and Genomics
The Pediatric Diagnostic Program will:
- develop a diagnostic and treatment plan that best meets the needs of the child and family
- facilitate further evaluation and treatment, often with the input of the larger team
- coordinate between, and communicate with, all the Boston Children's providers involved in the care of the child as well as their primary-care provider.
- provide comprehensive recommendations for the referring physician
- assist with connections to useful community resources


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What you can expect:
• Personal Service • Professional design options • Exceptional quality
The process:
We will email suggestions. You can request further options and make special requests.
Only acid free materials contact the art for long term preservation. Paper works are framed with plexi.
Canvas works are typically framed without plexi so that the vibrancy and interaction with light can be best appreciated.
Framing may be cancelled at any point before actual framing work begins.
Quality Guarantee. You may return your item for a refund within 15 days (excluding shipping).
Feel free to contact us with any questions you may have on this service!
No additional charge for shipping. Alaska and Hawaii addresses will have a higher rate which you can see in your cart by the "custom frame it" option.
Larissa Holt's style is reminiscent of the late world-renowned artist Eyvind Earle (1916-2000), with whom she worked to create a collection of iconic serigraphs. After leaving Eyvind's studios in 1989, Holt was involved in producing pieces for Henry Miller's Centennial Collection, Chris Lewis Fine Art, Neal Doty, and others. She also traveled and began to focus more on her own art, developing the bold contrast style she is known for today. Through the years, Holt has proven her skills as a talented printmaker and artist. Her work has been collected extensively by both private and corporate art connoisseurs, and she has won several first place and people's choice awards in both silkscreen and oil mediums. She has also had numerous solo and group exhibitions throughout the US, most notably in Seattle, Centralia, Portland, Florence, Eugene, New York, Big Sur, Pebble Beach, San Francisco, Los Angeles, New Orleans and Denver.


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(Alfred) John Cooper (1930-1998) was born in Sydney and educated at Christian Brothers College, Manly, and the University of New England. His career was spent in the field of arts administration. He served as state administrator and director of the Arts Council of New South Wales, as chairman of the New South Wales Opera Council, and secretary of the Professional Drama Council. He was associated with the Australia Council as director of its Entrepreneurial Program, the International Program and the Special Services Program.
John Cooper had a lifelong interest in religions and taught courses in Hinduism, Buddhism, the Gnostic tradition and Indian thought. In 1987 he gained a Master of Arts degree at the University of Sydney with a thesis entitled 'The Theosophical crisis in Australia: the story of the break-up of the Theosophical Society in Sydney from 1913-1923'. Shortly before his death, he completed his doctoral thesis on the letters of H.P. Blavatsky.
After his retirement Cooper and his wife bought a farm near Bega. It was here that he developed his great library and archives. He had travelled widely as a lecturer on Theosophy and invariably returned with books and documents. He was also helped by fellow-scholars throughout the world.
Shirley Cooper, the wife of John Cooper, donated the collection to the Library under the Cultural Gifts Program in 2004.
Printed materials
The collection contains 3874 books and pamphlets and 251 serials. The books fall into the following categories:
- Theosophy, 1851-1997
- Indian philosophy and religion, 1794-1996/li>
- Comparative religion, 1792-1997
- Esoteric, 1878-1997
- Buddhism, 1908-1997
- Krishnamurti, 1910-1996
- Helena Blavatsky, 1823-1997
- Zen, 1874-1991
- Tibet, 1879-1996
- Yoga, 1930-90
- Liberal Catholic Church, 1904-90
- Reference, 1949-97
The Theosophical books, about 1500 in total, include works of Annie Besant, C.W. Leadbetter, G.S. Arundale, Krishnamurti, Helena Blavatsky, William Judge, C. Jinarajadasa and Katherine Tingley. Other writers represented in the collection are Marie Byles, C.J. Jinarajadasa, Alice Bailey, Mircea Elaide, Geoffrey Hodson, A.P. Sinnett, Rudolf Steiner, Aleister Crowley, Dervla Murphy, Kathleen Raine, Colin Wilson and W.B. Yeats.
The serials, dating from 1979-1998, were mostly published in Australia, the United States, the United Kingdom and India, but there are also publications from many other countries.
Manuscripts and personal papers
These include correspondence, manuscripts, notebooks, photographs, photocopies of articles, reference files, circulars, newsletters and other publications. The principal subjects are the history of Theosophy in Australia, the lives of Helena Blavatsky and Krishnamurti, the Liberal Catholic Church in Sydney, and Theosophical history generally. There is a small amount of material relating to the Australia Council and arts festivals.
The books in the Cooper Collection have been kept together as a collection, while the serials have been integrated into the general serials collection. The books have been individually catalogued; the call numbers have the prefix COOP. A 399-page listing of the books and serials is available via the catalogue.
The manuscripts and papers in the Cooper Collection are housed in the Manuscripts Collection at MS Acc02/113
Gosling, Andrew, Connecting Asia and Australia, National Library of Australia News, vol. 16 (4), January 2006, pp. 14-17
Jackson, Philip, Historian's Theosophy collection acquired, Gateways, no. 57, June 2002, p. 1
Tillett, Gregory, John Cooper: obituary, Theosophical History, vol. 7 (4), Oct. 1998, pp 120-26
First posted 2008 (revised 2019)


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I've read a number of the helpful Q&As on photons that mention the mass/mass-less issue. Do I understand correctly that the idea of mass-less (a rest mass of 0) may be just a convention to make the equations work?
From a layperson's view, it's difficult to understand how a particle of light (photon) can be mass-less. A physical object (everyday world-large or quantum-small) must have a mass. Yet, if my understanding is correct, the mass of a moving object/particle increases in proportion to its speed/velocity...so that at the speed of light, its mass would be infinite. A photon travels at the speed of light, but it obviously doesn't have infinite mass, right? Can someone formulate a practical explanation that can be understood by middle-school to high school kids? Much thanks for the help.
Wow--your answers to my original Q below clear up much of my confusion. I now have the daunting task of going over these nuggets and working up an equation-less (hopefully) explanation of the mass-less photon for non-physicist types.
Yes, from a layperson's view, it does seem remarkable that an existing piece of matter-- which has to be made of physical substance--could have zero mass at rest (though a photon is never at rest). It would be almost understandable if a piece of matter made of nothing had zero mass, but that seems to be an oxymoron, and "nothing" would equate to nonexistent, right?
In case you might find it interesting: I'm working on a writing project that posits we inhabit a universe that consists of matter (physical stuff) only, and that the NON-physical (aka supernatural) does not (and cannot) exist. For instance, if a purported supernatural phenomenon is found to actually exist, then by definition, its existence is proof that it is mundane/natural. All it would take to disprove this premise is reliable proof that ONE supernatural event has occurred. Despite thousands of such claims, that's never yet happened.
Who else better than physicists to confirm my premise? However, I do wish the TV physicists would explain the terms they throw about, some of which mislead/confuse their lay viewers. Case in point: "The universe is made up of matter and energy" (without properly defining the term "energy" as a property of matter).
The result is that laypersons are left with the impression that energy must therefore be something apart from or independent of matter (ie, nonphysical). Their use of the term "pure energy" without specifying exactly what that means adds to the confusion. (Thanks to your replies on this forum, I now understand that "pure energy" refers to photon particles.) However, "psychics" and other charlatans take advantage of such confusion by hijacking terms like energy (as in "psychic energy"), frequencies, vibrations, etc to give perceived scientific legitimacy to their claims that a supernatural spirit world, etc., exists. As you may realize, the majority of people in the US (per 2009 Harris Poll) and around the world believe in the existence of nonphysical/supernatural stuff such as ghosts and spirits.
My purpose is to give laypersons the information they need to distinguish what's real from what's not.
Thanks so much for help...And, PLEASE, add any further comments you think might be helpful/insightful to better inform laypersons.


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Ernest C. Kemp
- BS Geology 1941
While enrolled at Michigan Technological University, Ernie Kemp enrolled in the first class of the Civil Pilot training program. He then became a flight instructor and flew many wartime flights over the Himalayas in World War II. After the war he returned to Michigan Tech and received his B.S. in Geology in 1941. He was then hired to teach geology here. In 1946 he moved to the new Sault Ste. Marie branch of Michigan Tech (now Lake Superior State University) and led the successful development of a geology program there.
Ernie achieved renown as an inspiring teacher and citizen of Sault Ste. Marie and received an Outstanding Teaching Award from LSSU in 1963. He was a much-loved teacher who was known for his sense of humor and commitment to helping students. He was also a mining consultant in Canada and the U.S. and then became the Dean of the Faculty for several years before his retirement in 1980.
From 1996 Induction to the Geological and Mining Engineering and Sciences Academy


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NIPTON, Calif. — Do you have $2.75 million to spare? You could become the owner of a tiny desert outpost in rural California.
The town of Nipton, California, is for sale after the idea to establish the community as a cannabis consumption destination went bust amid the COVID-19 pandemic.
On any given day, the number of trains passing by the Mojave desert town easily outnumbers the residents of Nipton.
Town dwellers ebb and flow around 25 people, some of whom work for nearby industries, including mining, solar power installation, and railroad.
Sometimes, curious passersby briefly hang their hats as well.
"I think the most important thing about Nipton is a lot of people come out, taking a couple of photos, taking a look at a small town's history, and we're still a town," said Stephen Sherin, one of the residents of Nipton.
Sherin, a long-time friend of the town's owner, Roxanne Lang, plays many roles since the town all but shut down due to the pandemic. Some days he's the unofficial historian and town tour guide, giving tours to visitors and telling them about how the town used to play host to movie stars and railroad magnates.
Sherin's most important role remains to help Nipton's owner sell for the right price and to the right buyer.
"$2.75 million is both the going, asking, and everything else price," Sherin said.
A look around the town of approximately 80 acres shows there's potential.
The town was slated to become a cannabis consumption destination for people looking to get away and to the dusty desert.
Sherin and the self-appointed Nipton Mayor, Jim Eslinger, says Arizona-based American Green ran out of money.
"I just don't see this being a marijuana cornucopia destination type place," Eslinger said.
In December 2019, Eslinger said he planned to embrace a marijuana ministry for followers to practice and consume in Nipton. Now, the town's future is a bit up in the air, and some of the residents are wondering what is coming next.
"I am grandfathered into the town, and I can be rented from time to time," Eslinger said.
The $2.75 million asking price includes several community buildings.
"What you get for [$2.75 million] is a general store, the outpost, the restaurant, the hotel which opened in 1905 — it's got five rooms," Sherin said. "Then there are five cabins, a container conversion, we have camping spots and the RV spaces across the road."
There's also more than 120 years of history dating back to the turn of the 19th century when steam engines chugged through the Ivanpah valley headed to Las Vegas and beyond.
"It's clear when you drive through town; it's not a ghost town. We have ghosts, but this is not a ghost town," Sherin said.
Torn teepees dot the field just behind Nipton, and tiny homes appear to be in near turn-key condition to welcome visitors who want to step into the wild west experience.
Art installations, including one artifact from the 2019 Burning Man Festival called "Perpetual Consumption," sprout from the desert floor.
"People come through here, and they go, 'we just had to come by and see it, we haven't been here in five years,'" Sherin said. "And so it's a little heartbreaking not to be able to turn out a Nipton burger, but Nipton's a town too tough to die, we'll be back."
Since the town has been back on the market in the latter part of 2020, there's been interest from approximately 30 buyers, according to Sherin.
"We're talking to a group off the East Coast," Sherin said. "Part of their family wants to see something going forward that is green, it's sustainable, it recognizes the past and embraces something we can do better for the future."
The town's current owner believes there is a bright future for Nipton, some 30 years after her late husband Jerry Freeman bought the near-ghost town with aspirations of reviving the town into a modern, green and sustainable community.
Lang says she hopes a new owner would attempt something similar.
This story was originally published by Joe Bartels on Scripps station KTNV in Las Vegas.


text:
Cranberry Banana Loaf
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From the kitchen of The More Family
This recipe has been on northpole.com from the beginning… since 1996! We hope you enjoy this classic North Pole recipe. Let us know your opinion by submitting a review!
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Recipe Details
Bake Time: |
minutes |
Tags: | Good for parties/potlucks, Travels well |
1/4 cup butter or margarine, melted
1 cup granulated sugar
2 eggs
2 or 3 (3/4 cup) mashed, ripe bananas
1 cup chopped cranberries, fresh or frozen
1 1/2 cups all purpose flour
1 1/2 teaspoons baking powder
1/2 teaspoon baking soda
1/2 teaspoon salt
1/2 teaspoon cinnamon
Preheat oven to 350 degrees.
Grease a 9x5 loaf pan.
Combine butter, sugar and 1 egg in mixing bowl. Beat until smooth. Beat in second egg.
Stir in banana and cranberries.
In separate bowl, combine flour, baking powder, soda, salt and cinnamon. Stir well.
Add all at once to banana mixture. Stir only to moisten.
Scrape into pan.
Bake in 350 degree oven for 1 hour or until it tests done.
Let stand 10 minutes. Remove from pan and place on cake rack to cool. Wrap.
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LWS5 says:
moist and yummy


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By Rich Mintzer
This article could probably be called the 100 most deadly mistakes in website design–there are so many goofs site builders make–but let's narrow the focus to the most disastrous 10. Avoid these gaffes, and your site will be far better than much of the competition.
1. Disabling the back button. Evil site authors long ago figured out how to break a browser's back button so that when a user pushes it, one of several undesired things happen: There's an immediate redirect to an unwanted location, the browser stays put because the "back" button has been deactivated, or a new window pops up and overtakes the screen. Our advice: Never do it. All that's accomplished is that viewers get annoyed and do not return to your site.
2. Opening new windows. Once upon a time, using multiple new frames to display content as a user clicked through a site was cool–a new thing in web design. Now it only annoys viewers because it ties up system resources, slows computer response and generally complicates a visitor's experience. Sure, it's easy to use this tool. But don't. With tabbed browsing common in browsers like Firefox, users who wish to open links in new tabs can do so if they wish.
3. Failing to put a phone number and address in several easy-to-find locations. If you're selling, you need to offer viewers multiple ways to contact you. The smartest route is to put up a "Contact Us" link that leads to complete info–mailing address, phone and email address. That link should be on each and every page of your website. Even if nobody ever calls, the very presence of this information adds real-world legitimacy and transparency to your site and comforts some viewers.
4. Broken links. Bad links–hyperlinks that do nothing when clicked or lead to "404" error pages–are the bane of any web surfer. Test your site–and do it weekly–to ensure that all links work as promised. Include a "Contact the Webmaster" link in your site's footer so users can quickly let you know if they find a broken link or other mistake on your site–and fix those errors immediately.
5. Slow server times. Slow load times are inexcusable with professional sites — it's an invitation to the visitor to click away. What's slow? A recent study by Akamai Technologies, commissioned through Jupiter Research, showed that online shoppers, on average, will wait only four seconds for a site to load before clicking away. If your site is loading significantly slower than this, put it on a diet–images may be too large or special add-ons, like a Flash introduction, may be slowing things down.
6. Outdated information. Again, there's no excuse, but it's amazing how many sites include old, dated content. Make sure to keep your site fresh and updated daily for best results. You can't afford the loss of credibility that can come from having dated content. Also, make sure your content is accurate, and if you should find a single error, fix it immediately.
7. Poor navigation. The internet promises speed. If surfers can't figure out where to go next quickly and get there easily, they'll simply surf on to the next website–your competitor's! It's very frustrating to be forced to go back two or three pages to get to other areas of a site. It's also a waste of time. There should be a navigation bar on every page that guides visitors to other areas of the site. Position the bar along the top of the page or along the left side so it will always be visible regardless of screen resolution. Add an easy-to-find site map in your main navigation bar and/or footer to provide visitors with an at-a-glance view of every page on your site.
8. Too many font styles and colors. Pages ought to present a unified, consistent look, but novice site builders–entranced by having hundreds of fonts at their fingertips, plus dozens of colors–frequently turn their pages into a garish mishmash. Use two or three fonts and colors per page, maximum. The idea is to reassure viewers of your solidity and stability, not to convince them you're wildly artistic. Also remember to make sure your font and colors look good on all possible devices from desktops to tablets to iPhones, etc.
9. Orphan pages. Memorize this: Every page in your site needs a readily seen link back to the home page. Why? Sometimes users will forward a URL to friends, who may visit and may want more information. But if the page they get is a dead end, forget it. Always put a link to "Home" on every page, and make your site logo (usually found near the top left side of the screen) link back to your home page–that will quickly solve this problem.
10. Failing to link with your social network sites. Most businesses have their own Facebook pages, others use Pinterest with boards full of photos, while some broadcast their latest activities on Twitter. The point is that social media is here to stay and businesses are benefiting from having a presence in it. Forgetting to link to your social media platforms is a big no-no. People should be able to go from one to the other effortlessly. Using social media to market your business and drive customers to your website will only work if you make it easy for users to move from one to the other. If done right, you can drive a lot more traffic to your site.
Nowadays there is lot of objectionable circumstance which force a person to take medicaments. There are variant problems when you have to buy drugs from the WEB. Certain drugs are as a rule used to treat numerous types of bacteria, such as bronchitis and infections of the nose. Generally, if you have lost the appeal to a particular partner, medicines like Levitra to improve potency is unlikely to help him back. Levitra is a curing used to treat varied problems. What do you think about https://isviagraoverthecounter.com/over-the-counter-muscle-relaxer.html? You may have heard about Numerous pharmacies describe it as . Probably you already heard about the question. Sex drive diseases are so ordinarily a product of what you've experienced that there is slightly to that "headache" saying after all. There are side effects possible with any type of drug. Generally remedies like Levitra has come under serious attention, special regarding its interaction with some medicaments. Your physician may occasionally change your dose to check you get perfect results.


text:
Regional CDL-A Solo Company Truck Driver
Company: Transco Lines
Location: Lexington
Posted on: July 9, 2024
Job Description:
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Our locations afford our drivers easy access, modern maintenance
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Transco Lines operates over 350 power units and 700 dry van
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Keywords: Transco Lines, Lexington , Regional CDL-A Solo Company Truck Driver, Professions , Lexington, Kentucky
here to apply!


text:
by Janet Elizabeth Henderson!
Follow the tour and enter to win great prizes!
2 grand
prize winners will receive a $10 Amazon Gift Card.
2 runner-ups will receive an e-copy of choice from Janet's backlist!
2 runner-ups will receive an e-copy of choice from Janet's backlist!
Visit all the blogs participating in the tour for reviews,
excerpts, guest posts and more chances to win!
About Reckless
The new London office of Benson Security hasn't even opened
its doors yet and already it's neck deep in its first case…
If the mission doesn't kill him, his sexy partner just
Dimitri Raast and Megan Donaldson have a common enemy—the
head of an organisation that specializes in human trafficking and sexual
They have similar motivation—Dimitri's sister was taken by the organisation,
and Megan's sister is threatened by it.
They have the same goal—eliminate their enemy and save their sisters.
Given they have so much in common, you would think working together would be a
piece of cake.
You would be wrong.
While Dimitri brings skills and experience from years as a
US Army Ranger to their partnership, Megan brings a background in failed career
choices and an ability to cause trouble wherever she goes. Yet, even with so
much at stake, Dimitri can't resist Megan's particular brand of crazy. She's
wild, she's sexy and she's fearless. An irresistible combination for a man who
lives his life completely in control. Now, after almost a year with one
all-consuming focus, Dimitri finds himself torn between rescuing his sister and
protecting the woman he wants - from herself.
Before she gets them both killed.
were meeting Johnny Rotten in a dark alley. Of course they were meeting a guy
called Johnny Rotten in a dark alley. Megan rolled her eyes. Obviously Johnny
went to the TV movie school of how to be a bad guy.
stay here." Dimitri pointed at a dumpster. Yeah. A dumpster. She half expected
some guy with a camera to shout cut and make them start again.
don't mean in the dumpster, right?" Because—eew!
Beside it. In the dark." He didn't even try to disguise that he was losing
patience. "Don't move, don't make a sound, don't interrupt."
blah, blah, let the big boys play. She was so tired of hearing the same old
tune. It was time to change the radio station.
Dimitri said. "I'm going to drive round and come in from the other end."
can't I just wait in the car? It's cold and it stinks here."
He stretched the word out. "You're supposed to be my hostage. I can't just let
you hang out in the car."
can pretend to be drugged."
Too dangerous. He might spot you, know who you are and that Rudi wants you.
Then what would stop him deciding to eliminate me and take you to Rudi
stamped her feet to get her blood circulating before the chill removed her
toes. "Why didn't you just take me back to the office?"
my backup." There was a silent 'idiot' attached to that sentence, she just knew
backup that hides in dumpsters?"
backup that phones for help if it looks like things are going south."
blushed, grateful he couldn't see it in the dark. "So, I need my phone?"
put his hands on his hips and looked skyward for a moment. "Where is it?"
She gave him what she hoped was an apologetic smile.
stomped off, cursing under his breath and came back a few minutes later with
the phone. "Sorted now?"
nodded. It probably wasn't the best time to tell him she really needed to use
the bathroom. She could hold it. How long did it take to have a covert meeting
in an alley anyway?
gave him a thumbs up and watched him march back to the car. Leaving her alone
in a stinky, dark alley. Alone and not thinking
about how good Dimitri's lips felt against hers. Nope. She wasn't thinking
about that at all. She was a professional—nearly. She had a job to do. She
backed into the shadows and tried to become invisible. Ninja Megan. She could
do it. It was all about the power of the mind. She closed her eyes and took a
few calming breaths.
when her stomach rumbled. Her hand smacked flat on it as she bit her lip. Maybe
all that fried food wasn't such a great idea after all. Not that she would ever
admit that to Dimitri. She was still mad at the man. Sure she'd been the first
to say they weren't in a relationship, but he didn't have to agree so
enthusiastically. He'd sounded affronted. As though she was the last person on
earth he'd consider dating. It was insulting. Her stomach made a strange bubbling
sound as she saw Dimitri's SUV pull up at the other end of the alley. He got
out and stood under the yellow glow of the street lamp. Waiting. Alert. Moody.
stomach rumbled again. Loudly. This wasn't good. So much for not making a
sound. Her own body was working against her. She crouched down in an attempt to
dull the noise, and hoped it worked. She closed her eyes, tried to calm her
stomach and think thoughts that made her invisible.
when she farted.
wasn't silent.
dropped her head to her knees. If the bad guys didn't get her, she'd die of
then her stomach rumbled again.
2016 Janet Elizabeth Henderson
(I received a copy from Barclay Publicity Blog Tours via Netgalley in exchange for my honest review)
Reckless by Janet Elizabeth Henderson is the first book from Benson's Boys and it's also the first book I've ever read by this author.
This book is filled with loads of humour, fun, and action. It's thrilling and fast paced and there were some great sex scenes.
Loved the chemistry between Megan and Dimitri, they really complement each other.
Megan and Dimitri both work for Benson Security and are on a mission to rescue Dimitri's sister. Megan's really reckless and even though she got out of it unscathed, there were serious repercussions that only she could deal with.
Overall, this is a great, thrilling and humorous read with plenty of romance; an all-rounder of a story that offers plenty for any reader.
Janet Elizabeth Henderson:
I grew up in Scotland, but now I'm
living in New Zealand - married to a Dutch man whom I met in America. (It can
get a little confusing in my household!) When I'm not living in my head, I'm a
mother to two tiny kids, three pet sheep, three miniature horses, three
alpacas, one dog, two cats, several chickens and an escape artist goat.
5 random things about me:
1. I accidentally mooned a crowd at
a Bolivian wedding.
2. I've been chased by a gang of
baboons. And I mean gang. They were organised and vicious. All that was missing
was their leather jackets and tattoos!
3. I wrote my first novel when I was
22. It was a cross between Star Wars, Monsters Inc. and Tinkerbelle. Funnily
enough, no one wanted to publish it. Odd that...
4. I was a portrait artist on the
streets of Amsterdam for a time.
5. I worked night shift as a
security guard at Stirling Castle in Scotland while I was in art college. The
castle was on a terrorist hit-list back then. To defend it they gave me a
flashlight, a two-way radio that only worked one-way and made me wear a
polyester A-line skirt...
If you'd like to sign up for my
newsletter, which happens sporadically - usually when books are being released
- then you'll find a form on my website. I hope you enjoy my books. Happy


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Pteris Cretica 'Albo Fern'
Plant sizing is based on the diameter of the nursery pot (2", 2.5", 3", 4" etc), not the plant itself. Plants may be slightly larger or smaller than the pot they are grow in depending on availability or time of year. While we do our best to ship plants as similar to those pictured as possible, please keep in mind that all plants are unique from one to the next, and display color, shape, and growth variation based on current environment, time of year, and other contributing factors. Please note that we ship our plants as dry as possible in the fall and winter months to prevent root rot or freezing. They will plump back up after planting!
Product information
30-Day Guarantee Details
The overwhelming majority of our orders are delivered without any issues. However, due to the complexities of packing and shipping live plants, sometimes things don't quite go as expected. For these rare instances, we offer this 30 Day Quality Guarantee to all our customers:
Our plants and products are guaranteed to be of excellent quality, well-rooted and disease free. If plants do not arrive in prime condition, customers may choose one of the following options
- Store credit + 10% (e.g.: $6 purchase + 10% = $6.60 store credit)
- Credit card, PayPal, or Amazon Pay refund
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This guarantee applies to all plants and products for up to 30 days after delivery.
All plants are shipped bare-root with the exception of Bulk Succulent Packs, House Plants, and Plant Club Subscription Boxes. House plants and succulents will ship from separate locations and may arrive at different times. Orders ship Monday-Friday each week. Please allow 1-3 business days for your order to be processed. We ship within the USA and its outlying territories ONLY. Read our full policy here.


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STRONGER THAN OE. GSP Heavy (HD) Duty Axles are the perfect upgrade/replacement for any rider. Whether you are looking to spread some sand or dominate terrains, our innovative upgrade from OEM axles feature heavier duty components to offer a strong, more reliable UTV Axle. From the materials we use to the grease we apply everything about the HD line is engineered to withstand the rigors of any terrain. With proper fitment, our HD Axles provide easy installation so you are ready to hit the trails in no time.
**Oversized 4340 Chromoly steel shafts increase strength by over 20%
**Utilizes TPE Boots to enhance performance in extreme conditions
**Heavy Duty OETIKER Clamps for improved strength and durability
**Precision inner joints engineered to achieve a swing angle of up to 45 degrees


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Privacy Policy
At Home Builders Association of Savannah. "HBA", we understand that the privacy of the information provided to us is very important to you. We use the data gathered only to provide you with more information about our products and services. This information will NOT be sold or distributed to any unaffiliated third parties without your prior consent. Any communication or material you provide to us, whether received online, electronically, in person or otherwise collected by or submitted to us, including any data, questions, comments, or chat sessions will be treated as non-confidential and non-proprietary. Anything you submit, transmit or post becomes the property of HBA Homes and may be used for any purpose, including, but not limited to, reproduction, disclosure, transmission, advertising, market research, and the development of prospect lists as permitted by law.
We may also use information transmitted to us through this website to send you electronic and other messages our communities, properties, or an offering from one of our vendors. Your use of our website constitutes your permission to do so. We comply with the Federal CAN-SPAM Act, and make every effort to ensure that our messages are not considered Spam. You may unsubscribe from any messages we send at any time and will not receive further electronic messages from us by following the instructions included within the message.
We may use third-party ad servers or ad networks to delivery ads to you on our behalf. These third-party ad servers may collect and use non-personally identifiable information about your visits to our site in order to present advertisement that may be of interest to you.
Information transmitted over the Internet may find its way to recipients to whom it is not intended or persons you may not want to have such information. Under certain circumstances, this may be beyond the control of HBA Homes, and you are advised that such transmission may not be secure. However, HBA Homes complies with applicable federal law regarding the safeguarding of your personal information, and we employ reasonable administrative, technical and physical safeguards to protect the security, confidentiality, and integrity of your information, as required by law.


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Intensive Weekly Chemotherapy for Advanced Gastric Cancer Using Fluorouracil, Cisplatin, Epi-Doxorubicin, 6S-Leucovorin, Glutathione, and Filgrastim: A Report From the Italian Group for the Study of Digestive Tract Cancer
Reviewers: John Han-Chih Chang, MD and Kenneth Blank, MD
Source: Journal of Clinical Oncology 1997; Volume 15 (11): pages 3313 - 19
Gastric cancer is the second most common cause of cancer death in the world. Only 10% are limited to the stomach at the time of diagnosis. Eighty percent of these patients have positive lymph nodes, 40% have peritoneal spread and 33% liver metastases at the time of diagnosis. Five-year survival data is abysmal at 5 - 15%. Therefore, due to the high incidence of metastases at diagnosis, much effort has been placed into optimizing systemic therapy.
Kelsen et al from Memorial Sloan Kettering Cancer Center reviewed the literature for the regimens that have been used for gastric cancer. Single agents utilized have been 5-FU, Mitomycin C, Adriamycin, and Cisplatin with response rates of 17 - 30%. Combination regimens include 5-FU/Adriamycin/Cisplatin (FAP), 5-FU/Adriamycin/Mitomycin C (FAM), etc. These treatments have a response rates of 30 - 36%. There is some excitement about Etoposide/Adriamycin/Cisplatin (EAP) with response rates of 64 - 70%, but median survivals are still only 9 - 18 months which are very similar to previous data with other regimens.
The Italian Group for the Study of Digestive Tract Cancer has now published their results of the pilot prospective study of intensive weekly Cisplatin, 5-FU, Leucovorin, epi-Doxirubicin, Glutathione and GCSF on 105 patients with unresectable locally advanced or metastatic disease with or without local resection of gastric primary lesion.
Materials and Methods
The selection of the chemotherapy was based on a number of factors. The combination of Cisplatin, 5-FU and epi-Doxirubicin (Adriamycin) had been shown to be an effective regimen in England, thus it was utilized here. Epi-Doxirubicin instead of Doxirubicin was because of a reported decreased incidence of mucositis. Leucovorin was used to enhance 5-FU's effect. Glutathione has been shown to reduce risk of Cisplatin induced neurotoxicity. Filgrastim was used to increase WBC and avoid neutropenia. The chemotherapy was given on the first day of each week. Initially, patients who responded or had stable disease after 8 weeks of treatment, would receive an additional 6 weeks. The Cisplatin was 40 mg/m2, 5-FU of 500 mg/m2 and epi-Doxirubicin of 35 mg/m2. Glutathione (1.5 mg/m2) was given on that day along with leucovorin (250 mg/m2). Filgrastim (GCSF) was given on the days when no chemotherapy was given.
From June of 1993 to September 1995, 10 institutions treated 105 enrolled patients with this regimen. Median follow up was 26 months. Objective tumor response was seen in 62% (65 of 105) with 17% (18 patients) achieving a clinical complete response. There were partial or complete responses (50% or more regression) in the metastatic lesions at various sites: 58% of 38 patients with liver metastases, 77% of 31 patients with positive lymph nodes, 55% of 38 patients with peritoneal metastases and 66% of 6 patients with lung metastases. Eighty-five patients had either stable disease or a clinical response. Twenty patients had only the initial eight weeks of treatment. Overall survival was poor, as to be expected from this population. Median survival was 11 months with one year rate of 42%, but a two year rate of 5%. Only 5% grade 4 leukopenia was seen and no grade 5 or fatal toxicities were seen.
The regimen proposed and studied by the Italian group has shown some promise, but survival continues to be abysmal despite a relatively high response rate. Such is the nature of this disease. It appears to have a good tolerance profile, though. In reference to the epi-Doxirubicin, there were only 3 grade mucositis events. The amount of neurotoxicity from Cisplatin seemed to be well controlled (only 3 grade 1-2 neuropathies), perhaps due to the utilization of Glutathione. The Italian group is proposing to begin randomized trials to look at the possibility of utilizing this as adjuvant or neo-adjuvant treatment in addition to surgery and/or radiation.


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Calligrapha Beetle
Scientific name:Order Coleoptera, family Chrysomelidae
Size: Adult—3/8"
Identification: Adults are oval, similar in shape to ladybugs, but they are leaf eaters. Head and thorax is dark metallic color; wing covers are ivory with dark splotches, dots, lines, and other markings that resemble a Rorschach test. These markings vary greatly. Antennae, legs, and mouthparts are dark in color.
Biology and life cycle: Complete metamorphosis. Adult females lay eggs on leaves and stems of plants. Larvae hatch and feed on foliage and then drop to the ground to pupate. Adults emerge and also feed on leaves from May to September. Overwinter in the soil as pupae or young adults. At the slightest disturbance, these beetles tend to drop off the tree to the ground to hide, which works well since they are about the color of brown leaves.
Habitat: Forests, parks, and large commercial properties.
Economic importance: Not significant. These beetles primarily attack and quickly defoliate sick, stressed trees.
Feeding habits: The larvae and adults feed on the foliage of dogwood, basswood, elm, and other shade trees.
Natural control: Maintain tree health.
Organic Control: Bacillus thuringiensis products work if sprayed early in the insect's life cycle. Plant oil products also work.
Insight: This very destructive insect is not often seen in Texas. This beetle is a good example of how a sick plant attracts insects that recycle it back into the soil.
A Howard Story: I've only run into the calligrapha one time. During one of my consulting visits to Frito-Lay's National Headquarters in Plano (the largest organic landscape project currently in the country), I noticed that two of the large American elms had a different look. The foliage was skeletonized and had the look of elm leaf beetle damage. On close inspection, we found these interesting looking beetles. Interesting but ravenous!
They were stripping the green out of the leaves in a hurry. The maintenance crew sprayed with pyrethrum, Bacillus Thuringiensis 'San Diego' and horticultural oil. At the time we didn't yet know about the power of citrus oil. We were all frustrated about how to control these pests until we finally followed our own advice and realized the cause of the infestation. These old American elms were in terribly poor health. They had in the past been hit by lightning, broken by wind storms and brutalized by the entrance road construction when the project was built in the late 1980's. The calligrapha beetles were just doing their job of helping nature remove these terminally ill trees. We got the message and helped. The trees were removed (improving the look of the area) and we haven't seen a calligrapha beetle since.
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