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CFI Innovation Fund Update Draft Call for Proposals for consultation
TO: Principals & Deans, Vice-Deans & Vice-Principals Research or equivalent
FROM: R. Paul Young, Vice-President Research
cc: Judith Chadwick, Assistant Vice-President, Research Services
cc: MayLiza Baak, Executive Director, Research Services
DATE: 16 October 2013
RE: CFI Innovation Fund Update – Draft Call for Proposals for consultation
The CFI has released the draft call for proposals for consultation. It can be found here.
We welcome your views and opinions on the University's approach to this competition as well as the CFI draft call for Proposals by October 23. Should you have questions, you are welcome to be in touch with me, Judith Chadwick, Assistant Vice-President, Research Services or MayLiza Baak, Executive Director, Research Services.
The total funding for this competition is $250M with an accompanying $75M through the IOF program. The Notice of Intent deadline is March 28 and a full proposal deadline June 27. Funding decisions are expected March 2015. Funding for this competition, while approximately $100M more than the 2012 competition, is still less than half of that in previous years. Based on the 3 year average of Tri-agency funding, the University + partner hospitals envelope is $105.3M. This is compared to $67.6M in the 2012 competition.
In the last two competitions, we applied an excellence-based, peer-reviewed approach for selecting campus-based proposals to submit to CFI. The result was highly successful we propose to follow a similar process in this competition. However, to maintain a competitive advantage we are seeking your input on ideas regarding innovative supports to applicants.
Key changes to this completion include:
· Encouragement of collaborative partnership
· Engagement with end-users of research or technology development knowledge for benefits to Canadians
· Minimum threshold of $500,000 total project cost
· Construction costs are eligible
· Each institution is permitted to participate in one multi-institutional project outside their envelope
We look forward to receiving your feedback regarding this competition


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I was very pleased to see the e-mail from my former colleague at Rutgers, Sumit Guha, sent to draw attention to the online portal to the Balochistan Archives. So many of us would love to go to Pakistan for research work, and so many of us will not be able to that any time soon. The availability of online records and files is still limited, but I hope the digital holdings grow quickly and soon.What is online already is fantastic--I just spent a large chunk of time reading about the 1935 Quetta Earthquake.
Balochistan Archives Entry Page
Balochistan Archives Facebook Page
Thursday, September 12, 2013
Balochistan Archives
Posted by JR at 8:32 AM
Labels: archives, Balochistan, Digital, Pakistan
2 comments:
- Hafeez Jamali said...
Dear JR,
Thanks for mentioning us on your blog. Our digital holdings are rather limited at the moment but we are planning a major digitization effort, conditional on the availability of funding. We also have a lovely Facebook page which is updated regularly with archival photographs, texts, and paintings. Please feel free to contact us should you or a researcher friend needs help with the archives.
Hafeez Jamali (Director)
- November 6, 2013 at 8:11 PM
- JR said...
I am very excited about your archive and looking forward to seeing it grow as funding becomes available! --S. N. Johnson-Roehr (JR)
- November 7, 2013 at 7:07 AM
Subscribe to: Post Comments (Atom)

subset: commoncrawl


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Mon-Fri: 12-inch breakfast toastie special
Look out Queenscliff, the mother of all breakfasts is here!
The team at 360Q are channelling their inner appetites and bringing you their 12-inch Sourdough toastie grilled to perfection with lashings of butter and filled with bacon, eggs & 360Q's exclusive Nanna Bev's Kick Arse chutney. This is the dish that made Barry Iddles and his crew so famous on the ski slopes at Falls Creek when he introduced it to his Elk restaurant, and now Bellarine locals can get in on the action too.
Now 360Q customers can get a toastie and a sensational coffee made by our expert baristas for just $12.50 between 8am and 11.30am on Monday to Friday.
This meal is delicious but be warned… this is not one for the fainthearted!
Of course our regular menu is a hit any day of the week too… See the full menu on our website here.
Also check out our Sunday night roast offer here. This weekly offer includes soup, roast meat with all the trimmings and dessert for just $40pp. This menu will change weekly too in order to offer a great variety for our customers.
Book a table online today using our new reservation system or call 5257 4200 and speak to one of our friendly staff.
360Q is located at 2 Wharf St East, Queenscliff.


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This is no ordinary
Chicken Wire Netting
instead, it's a 0.8mm thick, electro-welded, galvanised mesh chicken wire netting designed for poultry cages and runs where foxes are a particular menace - unlike some chicken wire, this mesh cannot be pulled out of shape which can sometimes lead to a fox gaining access to the coop.
Keeping chickens at home is a a very popular pastime and a throwback to the self sustaining days of 'The Good Life' when growing your own vegetables and producing your own food was very much the norm and trips to the shops or supermarket were reserved for essentials - but protecting your brood from hungry foxes is a perennial problem at this time of year.
Late autumn and early winter leads to a scarcity of small rodents which make up 50% of a rural fox's diet (roughly 30% for their town cousins) so chicken breeders and keepers really need to be on the ball at this time of year. We've already had a few reports of genuine fox activity around chicken runs in Suffolk, so here's a couple of tips on how to keep your chickens safe this winter...
Firstly, invest in a some quality
Chicken Wire Netting
for your run. We're not talking the usual thin gauge, flexible and pliable traditional mesh commonly known as chicken or rabbit wire here - foxes can pull this material out of shape and even bite right through it - but the real strong stuff.
This Chicken Wire Netting is an electro-welded 0.8mm thick mesh practically guaranteed to keep out hungry foxes as it doesn't lose its shape and they certainly can't bite through it! The 12mm mesh also puts the brakes on rat forays as they find it very difficult to squeeze through, but it's the foxes we're most concerned about and this netting really does represent a formidable barrier.
Secondly, don't forget that desperate times call for desperate measures and a fox with a taste for chicken will attempt to dig its way into the run. Just as you would protect a vegetable patch or allotment with rabbit wire, you'll need to combat sub-terranean raids by digging in the electro-welded chicken wire netting to a depth of at least 6" (12" to be totally confident). Once again, rats won't appreciate this barrier and your chickens can enjoy their food undisturbed.


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Item Atlantic early 1950's sailor outfit for Bleuette and Rosette
Bleuette and Rosette will don these lovely outfits when they go out with Tante Cecile and Lisette, to visit friends and relatives. They will of course behave beautifully, as they have been taught to do by Maman and the good Sisters at school. (But most certainly their thoughts will wander to the lovely trays filled with sweets and tea cakes!)
The summer version of Atlantic was made from white and navy cotton pique, with a tied neck ribbon. It is finished off with a perky Marin hat, with the word "Atlantic" printed on the silk ribbon band.
These charming sailor outfits can be made in either cotton or fine wool, with many variations or red, white and or blue.
Price =
Back to Previous Page


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Top LPN Programs in Michigan
The health care industry of Michigan gives employment opportunities to thousands of workers. The Michigan Board of Nursing was established to set a standard of education and approve nurse education programs. The board of nursing consists of three LPNs that are allowed to participate in all the matters except for those related to RN and the standard of education.
An LPN course may extend from nine months to a maximum of two years. At the end of training, a licensure test needs to be cleared in order to work as an LPN. The curriculum of LPN is structured in such a way that they get a glimpse of the basic functioning of a human body.
Mainly LPNs are involved in caring and taking care of the sick and injured patients. They assist the patients in dressing, bathing, and treating wounds. Candidates looking forward to make a mark in the field must qualify certain prerequisite conditions to get admission into an LPN course, and to work as a registered licensed practical nurse in the United States.
Nursing schools accredited by the board are deemed authenticated, and one must pursue LPN course from any of these recognized schools. There are more than 20 LPN schools in Michigan that provide practical nursing program in the state.
A nursing school ranks on the top according to the following criteria-
The nursing schools were then included in the ranking on the basis of following factors-
We hope that the list will help you to opt the best college as per your preferences in the state. The programs available in these colleges will give you an opportunity to begin your journey as a successful nurse.
Type of Course:Diploma
Muskegon Community College is one of the oldest community colleges and the top nursing school in Michigan. It was established in 1926 by the Muskegon Board of Education. The college has been accredited by the Higher Learning Commission of NCA, back in 1929. MCC got its accreditation in October 2013 to provide all the programs online. This college is committed to provide high standards of education to the students.
Type of Course:Certificate
West Shore Community College came into existence in 1967. The college makes the programs affordable for students by offering financial aid and services. It works in association with the industries that provide training program to the students so that they can get a job just after completion of the course. The college has been accredited by the Higher Learning Commission (HLC) and participates in AQIP; a program meant for continuous quality improvement.
Type of Course:Practical Nursing Certificate
The community college was established in 1965. The college lays special emphasis on sports by providing eight different sports program for the students. It has received its accreditation from Academic Quality Improvement Program (AQIP). The mission of the college is to provide educational programs that meet the demands of the students.
Type of Course:Diploma
Type of Course:Certificate
Type of Course:Certificate
LCC was established in 1957 to meet the demand of growing technical and specialized education. The college has been recognized as a leader in delivering excellence in academics and nurturing the students in the best possible environment.
Type of Course:Certificate
Jackson Community College was founded as Jackson Junior College in 1928. It is situated in a vast area of 500 acres, and is located at six miles south to Jackson. The college got its accreditation from the Higher Learning Commission and is a member of North Central Association of Colleges. It has a smoke-free campus that prohibits the use of any form of tobacco in the premises, protecting the health of students.
Type of Course:Certificate
Grand Rapids Community College was established in 1964. The average class size is 22.9 students in Michigan. The faculty members of the college are expert in their area and possess a doctoral or PhD degree. The college is dedicated to achieve excellence in all respects of work. It works with a mission of promoting employee, community and student learning. To reduce financial burden, the college offers funds and scholarships to the students.
Type of Course:Certificate
Schoolcraft College was established by the inhabitants of Garden City, Plymouth Canton, Livonia and Clarenceville school districts. The college has more than 3,6000 students enrolled in the various courses. It gives prime importance to the convenience of the students through flexible courses at daytime or evening time. Along with that, the courses are offered online, open exit, open entry, and hybrid in order to satisfy almost all kinds of students. The Schoolcraft College provides a life-changing experience, enriching the abilities of the students. It maintains a cordial, supportive, and pleasing atmosphere for the college staff and students.
Type of Course:Certificate & Degree
Type of Course:Certificate
Southwestern Michigan College has continually evolved with time, and now it offers more than 30 associate degrees comprising of programs aimed at immediate employment and four-year full bachelor courses. The college lives with a mission of providing access to high quality college life. "Excellence with a personal touch" is what the college is expert at delivering.
Type of Course:Certificate
Type of Course:Certificate
Type of Course:Certificate
Type of Course:Certificate
Northwestern Michigan College offers bachelor degrees, professional certificates, and associate degrees. The college has received its accreditation from the Higher Learning Commission. NMC is situated in a vast area of 100 acres and is running successfully since 1951. The students gain knowledge and a life-long learning experience that help them avail new opportunities and advance further.
Type of Course:Certificate
Kirtland Community College has its campus located at West branch. Grayling and Gaylord are other campuses. The central campus is at Roscommon. The college lays equal emphasis on inculcating extra-curricular hobbies and providing with the sports opportunities to the students, in addition to the academics.
Type of Course:Certificate
Type of Course:Certificate
Type of Course:Associate's Degree & Certificate
Type of Course:Certificate
Type of Course:Certificate
Type of Course:Certificate
Once you complete the LPN program from an accredited college, you need to give a licensure exam to start working as a professional worker. It is necessary to pass the NCLEX-PN test. For this, the candidate is required to complete and submit the licensure application with the required fees and the documents to the Michigan Board of Nursing.
Then the candidate must register with the company Pearson Professional Testing (PPT) that conducts the licensure examination. You can register at www.personview.com/inclex. After submission of the document and completing the registration process, the board approves the candidate, thereby making him/her eligible. Next, PPT would mail you ATT (Authorization to Test) and schedule the exam location, date and time as per your convenience. The candidate must schedule the test within 90 days of getting the ATT. It is also required that the applicants undergo a criminal background check (CBC) and a fingerprint test at an authorized institution. When your application and fee would be processed, you would get a customer ID number. Get the fingerprint done using the customer ID and the instructions given by the board. Fingerprint report must not be taken before getting the customer ID number.
If the candidate fails to succeed in the first three attempts of NCLEX-PN test, s/he must complete the PN exam review course and submit the certification of completion of the course to the board.
The application remains valid for a duration of 3 years, and if the requirements for licensure are not carried out after submission of application, it gets expired, and the aspirant has to submit a new application along with the fees. If the candidate has completed the LPN course from the United States, s/he must get the license within 2 years from the date of completion of the course.
The cost of applying to the board is $54, and the cost of examination is $200. Michigan nurse license verification is carried out by the Michigan Nurse Aide Registry that holds the information about the licensed nurses.
Those LPNs who hold an active license in any of the U.S. states can get the license in the state of Michigan. This would enable them to practice in the state.
Michigan does not come under nursing licensure compact state. The nurses who have an active license in any other state and desire to continue the services in Michigan too, must follow the below-given directions.
Along with completing the above requisites (mentioned for the English medium applicants outside the US), candidates are also supposed to fulfill the following requirement:
Livescan prints or identogo are considered for out-of-state candidates. The applicants are not eligible for licensure if they are having a current disciplinary sanction in any other state. They may be allowed by the board depending on the type of offense committed and considering the age factor.
License reinstatement is done when the candidate fails to get the license renewed before expiration, or the license is suspended. Reinstatement of LPN license can be done by sending the appropriate application with requisite fees and documents to the board. At least two affidavits should be accompanied with the application. The board also requires you to fulfill the following conditions.
If the Bureau or Office of Attorney General has filed your case, then a hearing would be arranged within next 30 days. In case of any query or doubt regarding reinstatement of the license, applicants can contact the office by calling at toll-free number 866-814-9004 or dropping a mail at [email protected]
The LPN license attained after passing the NCLEX-PN test has to be renewed after 2 years. The state of Michigan has made the renewal process very easy for the ease of the citizens. The candidates, whose license are close to the expiration date, can visit the following link to apply for the license renewal. The affidavits must confirm that the person holds a good conduct and is able to resume the services.
Visit the link, enter the current ID, and proceed to renew the license. The renewal fee for an LPN license is just $60. In addition to the fees, the board requires a proof of 25 Continuing Education CE. If the candidate fails to get the license renewed within 60 days of expiration, then the license is no longer valid.
If the license has been lost or tampered, then you can request a duplicate license. Write an application to the board asking for a duplicate license along with a fee of $10.00.
The application should be mailed to:
Department of Licensing and Regulatory Affairs
Bureau of Health Care Services
Health Professions Licensing Division
PO Box 30670, Lansing, MI 48909
Individuals who want to verify their license can get details on the website of the state nursing board. The information provided on this site is accurate and updated.
If you want to verify your licensure, click here. Fill your first name, last name, city, county, profession, license type, and license number. Then, click on "Search".
According to indeed.com, the average salary of licensed practical nurse was $52,000 (as of October 19, 2016). As per the Bureau of Labor Statistics, the mean hourly wage of an LPN was $21.95 and the annual mean salary was $45,530 (as of May, 2015).
|Job Title
|LPN Ambulatory
|LPN Long Term Care
|Correctional Prison Facility
|Medical Assistant Family Practice
|CNA Medical Surgical
|Patient Care Technician Student
|Nar Nursing Assistant Hope
|LPN Primary Care
|Clinical Nurse LPN
|Psychiatric Nurse
|Nurse RN LPN
|Renal Dialysis Nurse
|LPN Cma Rma
|Long Term Care LPN
Information Source: indeed.com
After close analysis of the above table, it can be concluded that the Psychiatric Nurse earned the maximum salary, i.e., $58,000, while the Patient Care Technician Student received the least, i.e., $17,000. The earnings of professionals with similar titles were reported to be between $17,000 and $58,000.
|Name of the City
|Ann Arbor
|Benton Harbor
|Dearborn Heights
|Royal Oak
|West Bloomfield
|Battle Creek
|Grand Rapids
|Sterling Heights
Information Source: salary.com
It is clear from the above table that LPNs earned the lowest salary (i.e., $41,081) in the city of Saginaw. With $47,066, Canton, Novi, and Ann Arbor paid the highest salary to these professionals.
The state of Michigan has immense growth opportunities for the students of nursing. The cities of Detroit and Grand Rapids have a good number of educational institutions and job opportunities for the LPNs. As per the reports of the Bureau of Labor Statistics, the average employment in the state for LPNs was 3.494 per 1000 jobs (as of May, 2015). This statistics indicate that at present, there is a shortage of nurses in Michigan. Moreover, LPN is the quickest way to start a career in the nursing industry. If the candidate wants to learn more in the field and proceed further, s/he can opt for a bachelor's or master's in nursing and get more lucrative job opportunities.


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Crunch founder Darren Fell named 2018 Practice Accountancy Pioneer of the Year
CEO and founder of online accounting specialists, Crunch, acknowledged for contributions to Accounting Excellence.


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12:05pm March 10, 2010 – Winner Announcement of Hilton "Be My Guest" certificate is comment # 14 from Flint, Michigan based on a Random.org pick. Congratulations. And again thanks from Loyalty Traveler to Hilton Hotels, Randy Petersen and BoardingArea.com, and all the entrants who had a dream. One of you got that dream. All the rest of you — pay up or wait for the next giveaway. And stick around BoardingArea.com. You may not get that room or flight for free, but you'll certainly get all you pay for and more.
***[original post below]
Loyalty Traveler is giving away a Hilton "Be My Guest" free night certificate valid "for one night of complimentary lodging (room and tax only) at any participating Hilton Hotel in the United States". Expiration date is June 30, 2010. Thanks to Hilton and BoardingArea.com for providing this gift to me to give to one of you.
Entry is easy.
Loyalty traveler entry procedure:
- Leave a comment on my blog before 12 noon Pacific time, Wednesday, March 10 using an email address where you can be reached if you are the winner.
- Important: Name the Hilton brand hotel nearest your home in your comment. (For example: for me it is the Hilton Garden Inn, Monterey, CA)
- One entry per person please.
One comment, selected at random, will be chosen as the winner and notified Wednesday, March 10.


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The smart Trick of coolsculpting in Phoenix That Nobody is DiscussingHis team is usually Expert and courteous. Dr. Meger has improved my lifetime, coming to his facility is among the finest decisions I have at any time created. I'd personally stimulate anyone to try and do exactly the same !"
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Stocks to Acquire Even if You Do Not Understand the Business! (Part 1)7 November 2007 - Features - Editor
Information technology stocks, which have never been placid, are in for even greater turbulence in the near future. Companies which write software, those that assemble hardware, marketers of portable devices, and wireless service providers, with all be affected, though their stocks may not all bounce up and down in equal measures. Virtualization, like the Internet, may have been a sleeping giant for decades after its first development, but it is now set to wake up and shake the world! It is already a force to reckon with in its relevant field, but not all investors are acquainted with these futuristic stocks.
Almost all computers and their peripherals have capabilities and capacities in excess of what users can deploy at particular points of time. No computer in this Millennium can function to its full potential unless it is able to communicate with other computers. All organizations of any significant size work through electronic networks and these groups of computers have to be utilized optimally. Computing work loads vary, but the investments in technology do not change between a Friday evening and peak work hours! Mobility is another driver of change: people want to stay in touch, access stored data, and use the Internet at all times. These are the key reasons why the future is bright for visualization.
The Business Significance of Virtualization Stocks
Is visualization a stand-alone business area, or should it join hands with mainstream manufacturers and service providers? The choices may not be left to the fledgling virtualization industry segment because their seniors in related technologies generate extraordinary amounts of cash. However, one demographic segment that stands to gain from this dynamism is the small investor: choosing the right visualization stocks just before IT majors begin to target them with acquisitive eyes, has potentials for high appreciation in the short-term. However, consolidation within the virtualization segment cannot be ruled out, especially for players with restricted product ranges.
A less attractive side-effect of the way in which virtualization impacts the IT space, relates to new capacities for entrenched product lines. Obsolescence looms large for some traditional leaders in IT if they are unable to integrate their architectures with evolving virtualization systems, or if they are cut off by competitive acquisitions of suppliers. There is also the prospect that rationalization of existing computing capacities by clients may not suit the growth plans of hardware companies. Virtualization is set to shake-up the IT sector, whichever perspective your related stocks may prompt! Will your portfolio join the winners, or could you get left behind?
The Future for Virtualization Stocks
The business achievements of virtualization sector stocks calls for more than deep technical expertise. All process changes need blends of innovation and customer insights. There is not much to be gained from academic excellence alone. The manner in which Federal Express has modified bar-coding technology is a telling example of how new technologies can be used for competitive advantage. Virtualization is an important means of using raw information to satisfy new customer needs. There are, as with most other developments in the field, complex considerations in making trade-offs between developing proprietary products, and facing customer rejections, because their purchases involve losses of flexibility. That is why some of the latest upgrades in virtualization involve making earlier discoveries more versatile and adaptable for use with third-party hardware and systems.
Stocks to Acquire Even if You Do Not Understand the Business! (Part 2)
- NASAA: Protecting Main Street Investors
- Thursday 16 October 2014 - Features
- Third Quarter Earnings Season Starts
- Thursday 16 October 2014 - Features
- Ethical Investing and Shareholder Activism
- Thursday 18 September 2014 - Markets
- Fed Interest Rate Policy Boosts Markets
- Thursday 18 September 2014 - Markets
- Ponzi Schemes Remain a Threat to Investors
- Thursday 4 September 2014 - News
- US Markets Respond Positively to FOMC Minutes
- Thursday 21 August 2014 - News
jalith: need the information how to start invest in stock market...
StockMarkets.com Team: Thank you for visiting StockMarkets.com. We do not represent the South Pacific Stock Exchange, so pl...
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kennedy edahdike: with a dynamic emerging global power,a bouyant stock market is a sine qua non for develpoment,the po...


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This National Guard position is for a Aircraft Engine Mechanic, Position Description Number D1635000and is part of the NJ 108th MXS, National Guard.Learn more about this agency
NATIONAL GUARD MEMBERSHIP IS REQUIRED: This is an excepted service position that requires membership in a compatible military assignment in the National Guard. Selectee will be required to wear the military uniform. Acceptance of an excepted service position constitutes concurrence with these requirements as a condition of employment. Applicants who are not currently a member of the National Guard must be eligible for immediate membership and employment in the National Guard in the military grade listed in this announcement.
As a Aircraft Engine Mechanic, WG-8602-10, you will:
- Troubleshoot, modify, repair, and perform sequential disassembly and assembly of gearboxes and auxiliary power units
- Analyze malfunctions using schematic and wiring diagrams, blueprints, manufacturer's specifications, computer diagnostics data, inspection findings, trending data and aircrew debriefs
- Requisition, process, and account for supply assets as required by the repairable processing system
- Perform engine run operation on installed and uninstalled engines to troubleshoot malfunctions or verify findings
Travel Required
Occasional travel - You may be expected to travel for this position.
Supervisory status
Job family (Series)
This job originated on www.usajobs.gov. For the full announcement and to apply, visit www.usajobs.gov/GetJob/ViewDetails/492533000. Only resumes submitted according to the instructions on the job announcement listed at www.usajobs.gov will be considered.


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You'd think a cornerback who played 12 seasons in the National Football League would have more than 14 career interceptions. Then again, this is Ike Taylor we are talking about and "Ike Taylor" and "interceptions" have never exactly gone together like peanut butter and jelly.
With that said, Ike Taylor had an excellent career and while he won't get the national play that Troy Polamalu did, Taylor had a significant hand in three Super Bowl appearances and two Lombardi Trophies.
He was the epitome of the Dick LeBeau-style cornerback who kept the play in front of him and then "tackled the catch" as he was taught to do.
Much like I felt with Polamalu, Taylor's retirement probably comes a couple of years later than it should have. The first sign of his deterioration was in the team's dubious loss to Tim Tebow and the Denver Broncos when Taylor was beaten by DeMaryius Thomas for the game-winner.
I didn't put that play on all Taylor as many did because I thought LeBeau should have never left the middle of the field wide open like that but either way, it was a sign that Ike Taylor was slowing down.
What I'll remember most about Taylor was his interception in the Super Bowl XL win over Seattle and his grueling runs up and down the hill in Latrobe every day after practice. There were few players who got as much out of themselves as Taylor did who became somewhat famous for his offseason conditioning.
His relationship with Steelers' Owner Dan Rooney has been one of great admiration and his respect within the organization is high.
Championship teams are never comprised of 100% all-stars because even the greatest teams need players like Ike Taylor who do their job to support the more high-profile players.
There's no question that time has passed him by and that this is the right decision but he should know Steelers Fans have great appreciation for him. Few have worked harder and gotten more out of themselves than Ike Taylor has.


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Search the Community
Showing results for tags 'Faith-related items'.
Found 1 result
A thread for anyone interested in topics of Christian faith--all invited.
Linda Garren posted a topic in Open ForumIn an effort to prevent offense by those who do not appreciate spiritually related things being included within the forum topics, this thread has been created for reading/posting/commenting/questioning by anyone interested in things of the Christian faith. As far as I could tell from the forum rules, this would not be against policy, and it's my hope it may be a source of encouragement, strength, and information for anyone to feel free to come to at any time. Any way we can cut back contention I think would be helpful. Perhaps others can create similar threads they would like to develop for specific beliefs they are passionate about. From Senior Living Ministries, Daily Devotional--Nov. 12, 2014 If you ever get a glimpse inside the nest of an eagle, you'll see something fascinating. A mother eagle starts building with thorns, broken branches, sharp rocks, and other items that seem entirely unsuitable for the project. Then she lines the nest with a thick padding of wool, feathers, and fur from animals she has killed, making it soft and comfortable for the eggs. But those who hope in the LORD will renew their strength. They will soar on wings like eagles; they will run and not grow weary, they will walk and not be faint.— ISAIAH 40:31 By the time the growing birds reach flying age, they don't want to leave because of the comfort of the soft nest. So the mother eagle begins pulling up the soft carpet, baring the sharp rocks and branches. As more of the bedding gets plucked up, the nest becomes more uncomfortable for the young eagles. This encourages them to leave their home and move on to more mature behavior. In order to move forward, the young eagles must be made uncomfortable. And in order for us to move forward into spiritual maturity, sometimes God does the same thing: He gets you out of your comfort zone and puts you in a place where you have to jump out and trust Him to help you soar! Wherever God is pushing you from being comfortable today, see it as a chance to develop a deeper trust in Him and soar on the wings of faith He's given you. Prayer Challenge Pray that God would show you where He wants you to jump out and trust Him to bring you to a new level in your spiritual journey.


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12 November 2017
West Tyrone MLA Tom Buchanan has expressed disgust at those behind a security alert in Omagh this morning, which has disrupted the annual Remembrance Sunday commemoration.
Security cordons are in place around the Tyrone County War Memorial which sits at the junction of Bridge Street and Drumragh Avenue in the town.
Mr Buchanan is amongst those attending events in the town and he said, "Remembrance Sunday is a day when we pause to commemorate all those from every background who paid the supreme sacrifice. It is disgusting that anyone would target a war memorial at any time, but on Remembrance Sunday it is an act of particular hatred.
Omagh has a long association of service within our Armed Forces and those who served came from all backgrounds and traditions. The cowardice of those who left this device stands in stark contrast to the bravery of those who are commemorated today.
Whilst the annual Remembrance Service has been able to continue in Omagh Academy, there has been an impact on the events which would normally take place. It is right that the security forces take all the necessary precautions and I would pay tribute to their efforts in keeping people safe."


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Local Vendors, Shopping
Shopportunity: Q Clothing Boutique 'Bloggers Night Out'—This Weekend!
Join Kim Pavao of Eleventh & Sixteenth for a night of spring fashion on March 22
WHAT: Round up your BBF's (Best Blogger Friends) and head to downtown SLC this weekend for a night of spring fashion, shopping, and styling tips and tricks with Kimberley Pavao of Eleventh & Sixteenth.
Kim will be sharing her top picks from Q Clothing Boutique's fresh spring arrivals and sharing her savvy advice for wearing the threads.
Pose for a photo, sip on Mo-Quito cocktails, nibble on bites from Caputo's Market and Honey Pies, and enjoy a 20-percent discount on new spring merchandise.
WHERE: Q Clothing Boutique (215 East Broadway, Salt Lake City)
WHEN: Saturday, March 22 from 6-9 p.m.
HOW: RSVP online
photo: Alexis June Weddings


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1. It would appear that The Guy likes me too. Yes, I am certain.
2. Tomorrow is the retrieval day for my egg donation. Trying not to be nervous as I'll be unconscious the whole time anyway. I hope the check clears quickly so I can go to IKEA on Friday and buy a new bed. I realize that's mercenary, but I have a feeling that it's going to be a little while before my ovaries go back to normal and my abdomen stops feeling like it's filled with highly sensitive Dazzle Dirt (tm), so I'm focusing on the immediate benefits.
3. I was rejected by my final grad school today, likely because my second letter of recommendation never freaking arrived. This entire application process was so fraught with stress and roadblocks, perhaps the universe was telling me that this just isn't the right time for me to be going back to school. At least, that's the line I'm taking...
4. Did I mention about The Guy? I did? Good. Just checking. :)
Wednesday, March 31, 2010
In Brief (because I'm tired)
1. It would appear that The Guy likes me too. Yes, I am certain.
Posted by the frog princess at 11:22 PM 4 comments
Monday, March 29, 2010
30 Going on 13
Once upon a time, many moons ago, a girl sat cross-legged on her bedroom floor, cradling a cordless phone in her lap and trying very hard to work up the nerve to dial. Finally, with a deep breath, she steeled her resolve and punched in the number.
Girl: Hello, [Boy]?
Boy: Yeah?
Girl: Hey, it's [Girl]. (Pause.) You know who I am, right?
Boy: Yeah, of course I do.
Girl: Um, Okay, So... I was just wondering... Wouldyougooutwithme?
Boy: Yes.
Girl: (Pause.) Really?
Boy: Yes, really.
Girl: Cool. (Pause.) So, ummm... watcha up to?
The hard part over, they talked for hours. They talked about music, TV, books, school. They had no classes together but made plans to meet at the library during study halls when school was back in session. She learned that the boy had actually asked her out (via a friend, naturally) months before, but she'd said no, because she'd had him confused with someone else.
It was Christmas Eve, 1993, and later that night the girl wrote giddily in her diary that she'd already given herself the best Christmas present she could ask for--a boyfriend.
They had declared themselves, they were a couple. Only then did they go about the task of getting to know each other. As it turns out, they were well-suited, and young love blossomed. It was four months before they even kissed. Five months before their first fight, break-up, and reunion. By Middle School standards, their 7 month relationship was practically a marriage; and when it ended (with no shortage of drama, as young relationships invariably do), she licked her wounds for a little while, then brushed herself off and moved on. The thing had run its course.
It's a simple story, I know, but when I look back on it that's what strikes me the most: simplicity.
The other day I was talking to The English Ex about our respective dating difficulties and he asked "Was it always this hard?" To which I could only reply, "No. It wasn't."
I miss the simplicity of being able to say, "Hey, I like you. If you like me too we should be a couple. Wanna try?" and saving all the worry over whether or not it's a good idea for a later date. Unfortunately, as a woman now officially in her 30s, saying that to any guy before even going on a single date would surely send him screaming in the opposite direction faster than you can say "Wedding Registry."
But that doesn't mean I don't want to do it.
Of course, I'm thinking about The Guy here, but I'm thinking about that Boy too. We barely knew each other. Hell, I didn't even realized he'd already asked me out, because I had his last name confused with someone else's! All I knew is that I thought he was cute and I got all jittery when I ran into him in the nurse's office one day (I had poison ivy, he was icing a sprained ankle)... and we were together for practically an eternity, from an adolescent standpoint. So how did we know? How did we know that we would actually get along, be good for each other, have anything in common? Was it some sort of crazy, relationship sixth sense? Or just blind luck?
I wish I knew, because I get the same feeling around The Guy... only magnified, and muddled by years of experience, of both the positive and negative variety.
I barely know him, though I do actually know his last name. I just know that I like him, I feel good when he's around, and when he's in the same space I want to be close to him.
So why can't I make that leap? Why can't I gather the nerve to simply say "Hey, let's go out sometime. Like now, for instance?" Why was my 13 year old self so much braver than my 30 year old self?
Perhaps it's because my 13 year old self had yet to feel the sting of real rejection. Rejection is like a poison ivy allergy--something else with which I am acutely familiar. Over time, the body's allergic reaction to poison ivy intensifies rather than diminishes, so that each subsequent exposure causes a more violent reaction until you're like me, and a simple brush with those three leaves from Hell means a trip to the doctor and lots of steroids. I think I react to rejection the same way. As time goes on and I experience it more and more, even the little rejections feel like earthquakes in my psyche.
Like I said, I barely know The Guy... but I have a feeling that if he shot me down, I would take it hard. Very hard. And doing a show together means I'll be seeing him fairly regularly for the next month or so, making it very difficult for me to lick my wounds and move on, as my 13 year old self would have done.
Granted I feel that I already made my intentions perfectly clear when I kissed him, but he is a guy, he could have just chalked that up to my being drunk. A kiss doesn't carry the same weight at 30 as it did at 13, which is a pity really, as it's still an infinitely enjoyable way to pass the time. Or maybe he's having the same, ridiculous inner monologue that I am, and we should both just get the hell over it and see what happens.
I have no way of knowing what he's thinking, what will happen, or what I will eventually do. For the moment I'm still stuck on my bedroom floor, staring at the wall and searching for the courage to dial.
Posted by the frog princess at 4:19 PM 4 comments
Sunday, March 28, 2010
Good Karma... and Money
Have you ever had one of those hangovers where it feels like your brain is suspended in jello, and every time you move your head, it bumps painfully into your skull?
Well after six days of hormones, that's how my reproductive organs feel. Or maybe like someone removed them all together and replaced them with a brick. A brick with lots of nerve endings. Similes aside, it is not exactly what you would call pleasant. Though on the plus side, my overwhelming horniness has abated for the time being, as the thought of anyone actually touching the lower half of my body makes me cringe.
Tomorrow morning's sonogram is going to be just a barrel of fun.
Now, at least, I'm starting to understand why the compensation for this process is so high. I don't mean to sound mercenary, and I know that I am giving someone a great gift... but in my present state of discomfort, cold hard cash is a far more tangible reward than good karma.
I've also developed a new-found respect for diabetics, or anyone else who has to administer subcutaneous medication while in a public place. I've had to inject myself twice while at work, and let me tell you... perching on the edge of a toilet seat with my tights around my knees and my skirt hiked up around my waist, preparing to stick a needle in my thigh while shouting "Occupied!" as one or more persons rattle the door trying to gain entry to the restroom is not a position in which I ever expected to find myself.
The subsiding of my sex drive, however, has not decreased my interest in The Guy in the slightest--leading me to believe that my attraction to him is not just the hormones and that, for better or for worse, I do actually like him. We had a late night text message conversation last night, and the fact that I've read over it a few times and can't help grinning while I do so also points in that direction.
Yep. I think I'm in trouble.
Posted by the frog princess at 9:30 PM 1 comments
Thursday, March 25, 2010
Day Three of Self-Injected Hormones: Still horny, though perhaps not as blindingly as before. Plagued by insomnia--again, not unusual for me, but definitely intensified. Maybe a tiny bit crampy from time to time, but nothing unbearable. Giving myself injections has turned out to be far less traumatic than I thought it would be. I was given the option of taking them in the thigh, and I quite literally can't even feel it. Definite WIN.
As to my personal life, I've seen The Guy (No, I really couldn't come up with a better nickname than that. I tried.) twice since the evening that I mauled him. Both times we were at rehearsal, and both times he has been cut before I was, thus thwarting my schemes to get him alone somewhere off theatre property--be it only the subway--in order to more objectively evaluate the situation. I have tried, and apparently failed, to indicate that I would enjoy doing just that. My subtler hints have gone unnoticed, and the one whopping LARGE hint--namely kissing him in a not-at-all-subtle fashion, right after saying something akin to "I'm far more attracted to you than I should be"--has not since been addressed.
It feels like the level of flirtation has escalated, but it's difficult for me to say when all of it is taking place in front of the rest of the cast--one of whom is aware of the events of the previous evening, having been in my inebriated company immediately thereafter. (If you think I have no filter in my blog, you should see me when I'm drunk.) The one significant change I can note is that, when he is supposed to kiss me on stage, he actually does so now, whereas before he'd been faking it. That may, or may not, be something.
In other words... I haven't got a frakking clue what is going on, and short of dragging him into the dressing room, locking the door, and having my way with him (or what way I can have under current restrictions), I'm not sure if or when I'll ever figure it out.
Not that I'm not enjoying myself along the way mind you. Flirting is fun. Cute boys are fun. Feeling slightly jittery around someone new is fun.
But by now you've all become at least mildly acquainted with my Crazy, and these hormones are not making her any easier to keep under control.
Right now, The Happy, Sane Froggy Who Just Enjoys the Moment is at a stalemate with the Crazy... but when that Stalemate becomes a Checkmate, well... I just don't know who's going to win.
Posted by the frog princess at 6:53 PM 2 comments
Monday, March 22, 2010
Stuff and Foolishness
There is simultaneously a lot and very little going on in my life these days.
I've started rehearsing for another show, which is taking up the majority of my free time, and much to my delight it is shaping up to be really great. I think I'll actually enjoy the curtain call this time around, unlike the last show where I just wanted to escape the stage, and my scene partner, as quickly as possible. Also unlike the last show, this time around I actually find the men I'm sharing the stage with--gasp!--attractive... one of them more than is probably good for me, but more on that in a minute.
The other news is that, after more than a year of waiting, I have finally begun my egg donation cycle! I took the stop-you-from-ovulating hormone shot a few weeks ago, and tomorrow I start the daily produce-lots-of-eggs hormones (giving myself shots--fun!). Thus far the only side effect I think I've noticed is being, well, exceptionally horny.
Now, granted, this isn't exactly an unusual state of affairs for me, so I'm not sure I can blame it entirely on the hormones, and I'm thinking the effect has been intensified by the fact that at the present moment, my lust actually has an object on which to fixate.
Which brings us back to the guy in my show. I say it's not good for me to be so attracted to him, mainly because he's a bit of a stoner and a bit of a flake (the two so often go hand in hand) and while stoner-ness doesn't bother me, one thing I absolutely cannot abide is flakiness. On the other hand, he's also cute, funny, and has a ridiculously sexy voice... and when he's in the vicinity I have a very hard time keeping myself from just pouncing on him and ripping his clothes off.
Indeed, the other night--after an inordinate amount of Yeungling--I entirely failed to control my lustful urges and stuck my tongue down his throat. He didn't seem to mind.
I can't help finding it ironic that I actually meet someone I want to have sex with right when I begin a process which will prohibit me from having sex for a month.
Unless, you know, I want to have a zillion babies. Which, clearly, I do not.
Fucking figures.
And absolutely none of the above prevented me from spending an entire 60 minute commute this morning indulging in daydreams about which, for the sake of decency, I will not go into detail. If there were any telepaths on the A train this morning, I highly doubt they were bored.
Now, I know what you're thinking, because I've thought it too. Maybe it's a good thing that I can't just jump into bed with him. Maybe this means I'll actually have to get to know him before sex becomes part of the equation. And you're right. Or you would be, if I was positive I wanted to date him. I'm not.
I try to take gossip with a grain of salt, but I was told he's got a reputation as a bit of a man-whore. There's the whole I-hate-flakiness thing, which I can tolerate in someone I'm only having sex with, but can't handle in an actual relationship. There's the fact that my judgment is currently so clouded by hormone-induced lust that I can't stop thinking about taking his shirt off long enough to determine exactly how much I like him. And finally there's the nagging fear that I do really like him, which, for all the reasons listed above, might turn out to be more of a curse than a blessing.
It seems that neither the course of true love NOR true lust ever doth run smooth...
Posted by the frog princess at 11:52 AM 2 comments


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MOSCOW, July 15 (Itar-Tass) - Russia's Tu-95MS strategic aircraft have started patrolling airspace as part of the large-scale military exercises now underway in the Far East, Major-General Igor Dylevsky of the General Staff told foreign military attaches on Monday, July 15.
The strategic missile carriers are operating from the base near Belogorsk, Amur Region, in order to "ensure strategic deterrence over the Sea of Japan and the Sea of Okhotsk," he said.
Dylevsky said the number of tanks and armoured fighting vehicles participating in the manoeuvres has been quintupled.
"The overall number of troops involved in the combat readiness drill is about 160,000, as well as more than 5,000 tanks and armoured fighting vehicles, 130 long-range and transport planes, jet fighters, bombers and army aircraft, up to 70 Navy ships and vessels," the general said.
Also additional 25 radar stations have been set up to provide anti-aircraft protection for the troops.
One of the special features of the current exercises is that units are travelling long distances of up to 1,000 kilometers under their own power. "This is never been done since Soviet times," Dylevsky said.
He said 16 military trains of 590 carriages are used to transport 682 pieces of hardware and 480 tonnes of materiel. Military transport planes have made 21 flights over the past 24 hours, redeployed 212 troops, 17 pieces of hardware and 410 tonnes of materiel.
"All redeployment operations will be completed by the end of the day," the general said.
"Most of the training tasks are being solved at the ranges unfamiliar to the participating troops -- Tsugol in Trans-Baikal Territory and Uspenovsky -- in Sakhalin in conditions as close to real combat as possible. This is also one of the key elements of the manoeuvres," Dylevsky said.
The ongoing military manoeuvres in the Russian Far East are not muscle flexing but a step towards better combat readiness, Deputy Defence Minister Anatoly Antonov told the foreign military attaches.
"Everything we do in the Russian Armed Forces, including combat readiness checks, is not an attempt to show our muscles. These are elements of daily, meticulous and well calculated work to improve the combat readiness of our Armed Forces," Antonov said.
Antonov stressed that the manouevres are "taking place in strict compliance with the obligations assumed by Russia earlier with regard to other states and are not aimed against them."
Explaining the need for the large-scale exercises in the Far East, Antonov said: "The Russian army must be able to act and be ready to respond to any threat from terrorist groups to attempts to violate Russia's sovereignty."
The meeting was attended by about 50 foreign military attaches accredited in Moscow or their representatives from key NATO, OSCE and CSTO countries as well as neighbouring or adjacent countries in the Far East.


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I love my grandmothers. They are both what I consider to be rock stars in the way that they share advice.
One of my favorite things is to have a very enlightening conversation with one of my grandmothers and several days later receive a call that she has popped an article in the mail. She loves to clip articles on topics that we have discussed and I love it!
The article that she shared recently was an article about Facebook that she found in the New York Times. We had discussed the nature of relationships on Facebook. I find that the relationships on Facebook aren't as solid as live in person relationships hence I have mostly stopped posting on Facebook. These blog posts still post to my page, but aside from that it has been awhile since my last actual post.
I would much rather go for a walk with a friend, meet for coffee or lunch, or even video chat as it makes me feel more connected to my friends.
What are your thoughts on Facebook relationships?


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The Chatham House is requesting the outstanding and interested applicants for Academy Asia Fellowship in the Queen Elizabeth II Academy for Leadership in International Affairs. The fellowship is awarded to citizens or nationality of Afghanistan, Australia, China, India, Indonesia, Japan, Pakistan and South Korea.
The fellowship is targeted at applicant at the mediocre-stage of their opportunities for progress and who come from academia, NGOs, business, government departments, civil society or the media. Chatham House, the Royal Institute of International Affairs, is an independent policy institute based in London. The objective is to support build a sustainable growth secure, prosperous and economic and social issues occurring in Asia and the world.
Description of Scholarship:
|Academy Asia Research Fellowships at Chatham House
in UK, 2018
- The Fellowship Application Deadline is open for the year 2018.
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- China's develop role in global governance
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Eligibility Criteria of Scholarship:
- The fellowship is awarded to the citizens of Afghanistan, Australia, China, India, Indonesia, Japan, Pakistan and South Korea.
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Children have so much to offer and we have so much to offer them. We need to remind them and teach them about God and what type of life God has given us. The love we share with them is God's love too! Discipline and politeness stems from the Bible. It is best to be a parent, not a friend. God gave us our children so that they learn to grow up and live life to the fullest. We are their teacher. Our children are our students. When they grow up and have their families, we will then become friends.
These are some of the most important points that I learned in the course:
- The Bible represents ultimate authority and moralilty. As parents, we should teach our children how to act and think morally.
- The greatest gift we can give our children is the confidence that mom and dad love each other.
- Love not only fills a child with confidence in your love, but it also fosters a love for others.
- Love is not rude.
- When you respect His creation, you are honoring God.
- Rewards are used to motivate behaviour not stimulate behaviour.
- Encouragement really reaps its rewards when you touch your child!
- Repentance begins with the offender and forgiveness begins with the offended.
- Children are ready for choices when they can handle not having any choices.
There is so much more that I learned but it is hard to summarize. If your church ever offers a course by the name Growing Kids God's Way by the Ezzo Family. I would suggest taking it. It gives you a lot of great info and great advice!


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Ordering among our specified quantities is usually a lot more cost-effective than a custom made estimate. Allow us to know the amount of units you want to delivered and We'll recycle the excess for you personally. Just pick the quantity of things you want recycled under the "transport" segment following placing your order.


text: The new works of Florian Süssmayr (born in Munich in 1963) show close-ups and still-lifes from the world of the metropolis. He zooms our gaze onto details of interiors. At such short range, curtains, tiles and tablecloths become ornaments in their own right. It is as though we, the viewers, are seeing objects through an intoxicated gaze that stubbornly stays put on them until they metamorphose and begin a life of their own. Süssmayr reduces the motif until all one can recognize is an ornament on the two-dimensional canvas, its painterliness taking precedence before all else. Record players, bottles and ashtrays are the objects that stand for a lifestyle in which nightlife and loneliness have an important part to play. Subdued colours, contrasts of light and shade, spatial composition and diffused lighting are the means by which Süssmayr seeks to reach the essence of painting.


text:
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Effective date: May 25th, 2014
Last Updated: June 17, 2018


text:
- Type: Hobo
- Material: Leather
- Designer: Bottega Veneta
- Hardware: Gunmetal
- Color: Brown
- Closure: Clip
- Size: Medium
- Pattern: Woven
- Season: Fall
- Occasion: Multiple use
- Condition: New
- External condition: Pristine
- Internal condition: Pristine
- Special features: unique gunmetal clip closure, signature BV woven design
- Includes: Bottega Veneta mirror, card and dust bag
- Dimensions: 14.5" x 11"
Our Pursonal Thoughts
This authentic Bottega Veneta Woven Knot Hobo is in brand new, unworn condition. A unique style from BV that has all the classic design elements that we love and then some.
Intrecciato woven leather in a beautiful deep brown, known as "ebano." The color is best depicted in the dust bag photograph. Slightly slouched in the front, a gunmetal clip attached to a leather ring acts as the closure. The single thick strap is extremely soft and comfortably worn over the shoulder or at the elbow. Beige suede lining has one slip pocket. Made in Italy.
Purchase includes Bottega Veneta leather wrapped mirror, authenticity card, and dust bag.
Retail price $1,480.00. Save $780.00 with StrictlyPursonal price of $700.00.
Attention Overseas Buyers: We are pleased to offer our overseas clients a flat shipping fee of $200.00. All overseas shipping is provided by UPS Global with signature requirements; the safest and most reliable method to ensure your bag arrives safely. Please note in the case of a return, entire shipping cost is the responsibility of the buyer.


text:
It has been cold, snowy or rainy here.
Quite a shock to the ol' system after the sweltering humidity of Orlando.
But I thought I'd update you on Kean after
completing his first full week back at school.
(Plus, I had to grab this picture that actually shows
him with his hat ON-- he hates hats, gloves, shoes....).
Kean had his best week yet.
Every day his aid, "Baker" sends home a form
she fills out that tells me what he ate, how many diapers
he had changed, what he worked on, what type of
therapy or special he had etc.
This week, for the first time ever, every day
had a good or great note.
He's starting to follow directions and class routines.
And here's the biggie-- a whole week without
pinching, pushing or pulling another child's hair.
He's even making friends.
This week, he was invited to a birthday party (dang, can't go)
and this little homemade horse came home in his back pack one day-
from a friend in class who made it specially for Kean.
Doing a little happy dance over here!


text:
Mobilink has introduced "International JAZZ Load" in collaboration with ezetop for its valued customers, enabling its customers to recharge Jazz accounts from international destinations.
customers can top-up the JAZZ Connection of your loved ones in Pakistan, from UK, USA, Spain, UAE and Saudi Arabia. This service will soon be available in more international destinations.
How to Jazz Load from International Locations?
To send JAZZ Load to Pakistan, just go to any of the ezetop affiliated retailer/money exchange near you OR visit www.ezetop.com and recharge JAZZ balance for anyone in Pakistan by following few simple steps mentioned below:
Through Retailer/Money Exchange:
- Go to any ezetop affiliated retailer/money exchange
- Request the agent/retailer to send top-up to any JAZZ Number in Pakistan
- Inform the agent/retailer of the amount and JAZZ Number
- Pay cash to agent/retailer
Through Website:
- Visit www.ezetop.com
- Register with ezetop website
- Select Pakistan as country and JAZZ as operator
- Enter the JAZZ Number and select the amount to top-up
- Enter the credit/debit card information and complete the transaction
Customers from abroad may contact following numbers for ezetop customer support:
- Saudi Arabia: 0550412342, 059-9656650


text:
Document Type
Degree Name
Dept. of Molecular and Medical Genetics
Oregon Health & Science University
c-Myc is a powerful oncoprotein whose expression is misregulated in a wide variety of human tumors. Studies of conditional c-Myc transgenic mouse models have demonstrated that loss of c-Myc from tumors may induce tumor regression. Therefore expanding our understanding of the regulation of c-Myc function and its degradation is critical to developing new targeted cancer therapies. In this study I use Saccharomyces cerevisiae, the budding yeast, as a model system to examine c-Myc degradation, as well as to identify novel c-Myc binding partners. Specifically, I found that c-Myc is phosphorylated at Threonine 58 (T58) and Serine 62 (S62) in an interdependent and sequential manner in yeast cells, as has been reported to occur in mammalian cells. Additionally, phosphorylation at these sites regulates c-Myc stability in yeast as in mammalian cells. Furthermore, yeast orthologs of mammalian proteins that regulate phosphorylation and dephosphorylation events on S62 and T58 in mammalian cells, appear to largely play a role in regulating the phosphorylation events on these sites in yeast. This is an important finding because it supports the discoveries made in mammalian cells. Additionally, it has been demonstrated that alterations in phosphorylation of T58 and S62 change the affinity c-Myc has for binding proteins that regulate its stability. It has also been reported that phosphorylation at these sites alter c-Myc activity. Therefore, this study also validates the use of S. cerevisiae to screen for novel c-Myc interacting proteins that regulate c-Myc stability and/or function. In my yeast two-hybrid screen I identified ten potential new c-Myc interacting proteins that appear to bind within the transactivational domain (TAD) of c-Myc, three of which have been validated to interact in mammalian cells. One of these proteins, HMG Box Protein1 (HBP1), has been described as a tumor suppresser protein. Therefore, I characterized the interaction between HBP1 and c-Myc. Specifically, I found that HBP1 can bind to both the TAD and C-terminus of c-Myc in mammalian cells. This interaction appears to prevent c-Myc from binding the promoters of its target genes, thereby inhibiting c-Myc transactivational activity. This is a significant finding because it further solidifies the role of HBP1 as a tumor suppressor protein and it increases our understanding of the regulation of activity of the c-Myc oncoprotein.
School of Medicine
Recommended Citation
Escamilla-Powers, Julienne Rebeca, "Identification of proteins that regulate c-Myc stability and function" (2008). Scholar Archive. 500.


text:
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