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Archive for the 'Hormone Clinic' Category
Bio-Identical Hormone Replacement Therapy – Hormone Clinic
Youve been using Natural Hormones all your life, why change now?
The term Bio-identical Hormone Replacement Therapy is interchangable with Natural Hormone Replacement Therapy.
Health is a holistic goal, and hormonal health put simply, is a large significant factor of that big picture. To control your hormonal health you need towork with an understanding doctorwho believes in the value of hormonal testing to use as a tool in the treatment of your health.
Combining your symptoms with your hormonal profile, looking at you individually, and considering your own, and your family history a picture can be brought into focus. Once obtained, this picture of your individuality can be used to give you a predictable and active future so that age is not a barrier to wellness.
When hormone supplementation is warranted, there arefour major points to consider. These stem from the belief that if we are going to relieve or reverse the ageing process, it should be done in such a way as to mimic the bodys system as it was created. In that endeavour, only hormones that are the exact molecules made by the human endocrine system should be used. The human race would not have survived this long if these hormones were dangerous and subjected us to fatal diseases.
Secondly, those hormones used should be introduced into the bloodstream in a way that emulates the glands as closely as possible, that is, avoiding the digestive tract and liver and minimising first-pass effects.
Thirdlya broader spectrum of hormones, at lower doses, offers a more complete, physiological balance.
Finallythe dose must be individualised to the patients needs and goals which in the end will result in fewer side effects if any, along with reducing or eliminating other medical problems.
Bio-identical Hormone Replacement Therapyproducts are compounded by a compounding pharmacist, which offers you and your physician a choice for individualised hormone replacement.
Naturalrefers to thestructureof the hormone (i.e. they are bio-identical in structure and function to the hormones naturally produced in our bodies). The hormones start from wild yam and soybeans which are rich in precursor molecules. These are easily converted by biochemists into other molecules that areidentical in all aspectsto our own naturally occurring hormones.
It should be emphasised that although these precursor molecules can be synthesised into natural bio-identical hormones in a test tube, our bodies are incapable of doing so. Therefore although wild yam creams are good moisturisers they do nothing to increase our hormonal levels.
Insulin used by diabetics was obtained in the past from pigs, which saved many lives, yet caused a significant amount of side effects and problems. Pig insulin is no longer used by diabetics as a Natural identical human insulin has been established, overriding any reason for using pig insulin. In this same light, there is now NO cause for women to be using oestrogens and progesterones produced from the urine of pregnant mares, aswe now have natural bio-identical human hormones available.
Bio-identical hormone replacement therapy is administered generally, in the form of atroche(lozenge) or as a transdermal cream which areabsorbed into the blood streamwithout having to go through the digestive system creating stress on the liver. We find Troches are the most suited form for Natural Hormone Replacement Therapy mainly because of the ease in which the ingredients in each prescription can be altered, and because of their superior transbuccal absorption.
Compare this to the mass produced formulas available commercially where titrating a dose is almost impossible and one must fit in with what is available.
Results have been good to excellent and in many cases extraordinary. The natural or bio-identical hormones used in the treatment of menopause are any combination of natural Progesterone, Oestrogen, Testosterone, at levels determined specifically for each patient.
Trochescan be mixed so that each individual troche contains a combination of various natural bio-identical hormones in small doses. For example, a troche can be made containing a mixture of any of the hormones, eg: oestrogen, progesterone, testosterone in any possible doses according to your needs. This combination is used to treat the symptoms of menopause.
Small doses oftestosteroneare useful inmenopausefor depression, to enhance energy levels, mood and libido without causing side effects.
Troches containing natural progesterone alone are helpful for premenstrual syndrome and peri menopause and can be taken during the latter half of the menstrual cycle to alleviate depression, migraine, nausea and basically all those PMT symptoms that occur premenstrually.
Menopausal women who have had ahysterectomycan benefit from troches containingnatural bio-identical estrogens,progesteroneandtestosterone. Even though the uterus may not be present, in the case of hysterectomy,progesterone is still essentialto balance the oestrogen component and stop oestrogenic side effects. Your requirements should be determined with a blood test to measure your sex hormones we recommend tests for blood oestrogen, progesterone and testosterone.
Troches can be made palatable, by making them in different flavours. Each troche is made up on an individual basis and the whole process takes a few days.
Once deciding to embark on taking hormone replacement one is usually forced to grapple with the risk/benefits factor. It must be stressed that although we believe Bio-identical hormones used in troches may be safer than Synthetic hormones,there are still risksrelating to the use of natural hormones. These risks are mostly related to the uses of oestrogen and the increase risk of breast cancer. For medicolegal purposes we have to assume the use of bio-identical hormones carries the same risk as synthetic hormones. The current thinking suggests that if we need to use any form of oestrogen to treat menopause we should attempt to stop this within 2 yrs of commencement.
Tailor made troches allow slow reduction of oestrogen and in my experience it is most definitely easier to slowly wean a patient off Oestrogen due to ease of dose adjustment. It would appear that continuation on progesterone and testosterone over a longer period is a safer option.
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Bio-Identical Hormone Replacement Therapy – Hormone Clinic
HGH and Testosterone Therapy Clinics in Newark, New Jersey
Human growth hormone ,testosterone injectables, Hrt ,Low T, weight loss, vitamin therapies and testosterone therapies, all offered Trough out New Jersey and surrounding areas. We Provide all Types of therapies and more.
Please fillout your information for a free consultation or give us a call 1-888-510-0698to arrange a appointment at your earliest convenience.
If you suffer from low energy, weight gain. Low sexual libido, low T, low testosterone, fatigue, joint pain, slow recovery, Please fell free to contact us.
At Hollywood Health and longevity Center we have serviced over 5,000 patients for over 7 years
Give us a call 1-888-488-0151. or fill out or form for free consultation
115 Christopher Columbus DriveSuite 202Jersey City, NJ 07302
44 Ridge RdN. Arlington, NJ 07031
51 JFK ParkwayFirst floor WestShort Hills, NJ 07078
712 E. Bay Ave.Suite 14Manahawkin, NJ 08050
425 12th StHamonton, NJ 08037
199 6th Ave, Suite DRoute 38 EastMount Laurel, NJ 08043
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HGH and Testosterone Therapy Clinics in Newark, New Jersey
Hormone Replacement Therapy From Wellness MGT corp.
Every aging adult struggles with problems of aging. What most of them dont realize is that aging is simply a scapegoat for all the troubles, physical and mental, that one experiences. Simply chalking up your aches and pains to old age will do you no good in improving your health when it is most critical to your well-being.
In fact, many of the struggles an aging adult goes through is caused by declining hormonal levels of the body. Theres no need to panic, for you are not alone in this struggle. The good news is that you, like thousands of others, have the potential of reversing the negative effects that comes with deteriorating hormones.
You may be asking, but how? Well the answer is right here, with hormone replacement therapy you can bring back the physical state and mental health you had when hormone levels were at a peak.
Hormone therapy has proven to do wonders for the mind and body in males and females alike. Many have already taken advantage of the opportunity to implement hormone therapy for weight loss, preventing disease, and improving mental health, among many others. First, lets talk about hormone therapy for weight loss. A direct link has been found between hormonal activity and body mass. Lets face it, as you get older, no matter how intense your diet or exercise is, your body is just more and more resistant to weight loss. Your metabolism just isnt what it used to be.
Perhaps in your youth you were one of those people who could eat anything they wanted in large quantities and still never showed a sign of a single extra pound. Well, those days are probably long gone by now. Although this is common, whos to say that we should just accept it? On the contrary, people who have decided to fight against this by using hormone therapy are experiencing amazing results. Every single adult, age 30 and older, has the opportunity to experience a healthy lifestyle, and we are the ones to present them with that opportunity.
Hormone therapy for men and women helps you get healthy, stronger, and happier overall. It is absolutely the best option for any aging adult, simply because it is a natural treatment. Your bodys hormones, such as testosterone, estrogen, and many others, are responsible for managing your bodily systems.
At a young age, they are working at full potential, which is why you look and feel great. Naturally, as they begin to plummet, so does your bodys activity and upkeep. Implementing hormone replacement therapy does your mind and body a huge favor in rejuvenating the hormones it requires to function properly.
Our products result in improved energy, stamina, quality of sleep, sex drive and performance, muscle building, as well as factors critical to your health such as regulated blood pressure levels and much more.
The options we offer to our customers are only the safest and most effective on the market. Get quality hormone therapy for men and women completely legally and hassle-free.
Best of all, the products we offer are 100% natural. Why poison your body with artificial supplements and products that will only end up doing more harm in the long run?
Make the choice to treat your body to exactly the hormones its lacking and give it the ability to run at full potential like it once used to.
Wellness MGT corp. in Google+
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Hormone Replacement Therapy From Wellness MGT corp.
Feminizing hormone therapy – Mayo Clinic
Feminizing hormone therapy is used to induce physical changes in your body caused by female hormones during puberty (secondary sex characteristics) to promote the matching of your gender identity and your body (gender congruence). If feminizing hormone therapy is started before the changes of male puberty begin, male secondary sex characteristics, such as increased body hair and changes in voice pitch, can be avoided. Feminizing hormone therapy is also referred to as cross-sex hormone therapy.
During feminizing hormone therapy, you'll be given medication to block the action of the hormone testosterone. You'll also be given the hormone estrogen to decrease testosterone production and induce feminine secondary sex characteristics. Changes caused by these medications can be temporary or permanent. Feminizing hormone therapy can be done alone or in combination with feminizing surgery.
Feminizing hormone therapy isn't for all transgender women, however. Feminizing hormone therapy can affect your fertility and sexual function and cause other health problems. Your doctor can help you weigh the risks and benefits.
Mayo Clinic's approach
Feminizing hormone therapy is used to alter your hormone levels to match your gender identity. Typically, people who seek feminizing hormone therapy experience distress due to a difference between experienced or expressed gender and sex assigned at birth (gender dysphoria). To avoid excess risk, the goal is to maintain hormone levels in the normal range for the target gender.
Feminizing hormone therapy can:
Although use of hormones is currently not approved by the Food and Drug Administration for the treatment of gender dysphoria, research suggests that it can be safe and effective.
If used in an adolescent, hormone therapy typically begins at age 16. Ideally, treatment starts before the development of secondary sex characteristics so that teens can go through puberty as their identified gender. Hormone therapy is not typically used in children.
Feminizing hormone therapy isn't for all trans women. Your doctor might discourage feminizing hormone therapy if you:
Talk to your doctor about the changes in your body and any concerns you might have. Complications of feminizing hormone therapy might include:
Current evidence indicates that there is no increased risk of breast cancer.
Because feminizing hormone therapy might reduce your fertility, you'll need to make decisions about future childbearing before starting treatment. The risk of permanent infertility increases with long-term use of hormones, especially when hormone therapy is initiated before puberty. Even after discontinuation of hormone therapy, testicular function might not recover sufficiently to ensure conception.
If you want to have biological children, talk to your doctor about freezing your sperm (sperm cryopreservation) before beginning feminizing hormone therapy.
Other side effects of estrogen use in trans women include reduced libido, erectile function and ejaculation. Erectile function might improve with the use of oral medications such as sildenafil (Viagra) or tadalafil (Adcirca, Cialis).
Before starting feminizing hormone therapy, your doctor will evaluate your health to rule out or address any medical conditions that might affect or contraindicate treatment. The evaluation might include:
You might also need a mental health evaluation by a provider with expertise in transgender health. The evaluation might assess:
Adolescents younger than age 18, accompanied by their parents or guardians, also should see doctors and mental health providers with expertise in pediatric transgender health to discuss the risks of hormone therapy, as well as the effects and possible complications of gender transition.
Typically, you'll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. This blocks male sex hormone (androgen) receptors and can suppress testosterone production.
After six to eight weeks, you'll begin taking estrogen to decrease testosterone production and induce feminization. Estrogen can be taken in a variety of methods, including as a pill, by injection or in skin preparations, such as a cream, gel, spray or patch. Don't take estrogen orally, however, if you have a personal or family history of venous thrombosis. Use of gonadotropin-releasing hormone (Gn-RH) analogs to suppress testosterone production might allow you to take lower estrogen doses and wouldn't require the use of spironolactone. However, Gn-RH analogs are more expensive.
Additional therapies might include:
Feminizing hormone therapy will begin producing changes in your body within weeks to months. Your timeline might look as follows:
During your first year of feminizing hormone therapy, you'll need to see your doctor approximately every three months for checkups, as well as anytime you make changes to your hormone regimen. Your doctor will:
After feminizing hormone therapy, you will also need routine preventive care, including:
Oct. 07, 2017
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Feminizing hormone therapy – Mayo Clinic
Nu You Med Clinic – Hormone Replacement Therapy Frankfort, KY
We started this clinic for natural hormone replacement in Frankfort, KY because my patients were fatigued with the lack of energy. They had loss of memory and difficulty thinking at times. They displayed irritability, anxiety, and depression-like symptoms. They were having decreased loss of muscle strength with joint pain. Along with these symptoms, they lacked sexual desire and performance. I knew their hormones were to blame but the medicines offered by the conventional medical community had potential side effects or even caused heart attacks, stroke, DVTs and cancer and I didnt really see them as effective.
I searched for a long time to find the right solution that would be safe for my patients, be effective and reverse all the symptoms they were experiencing. I found it in Human-identical Hormone Therapy or HRT for short. These hormones, along with some supplements, allowed my patients to regain energy and muscle strength while feeling younger and happier. They had increased mental clarity and ability to lose weight again. It restored or increased their sex drive and performance while decreasing their joint and muscle pain. Its been a great experience and we are just starting out. We are seeing people get theirlife back to want they want it to be. They are Living Happier and Aging Healthier.
If you want to see a video about what Dr. Lingreen thinks about hormone replacement pleasewatch the following:
Call to speak to a representative and see if Balanced Hormone therapy in Frankfort, KY is right for you. Just call (855) 592-4683 and leave a Voice Message and our staff will call you back.
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Nu You Med Clinic – Hormone Replacement Therapy Frankfort, KY
Sarapy Clinic – Hormone Replacement Therapy & Medical …
Doctor Sarah Ghayouri M.D.
San Diego Doctor Sarah K. Ghayouriis an internal medicine doctor, or internist, with more than 20 years of experience in adult medical care. She focuses on optimizing your overall health, disease prevention, medical weight loss to reverse obesity, and using anti-aging treatments to slow the aging process such as endocrinologist hormone replacement therapy and cosmetic dermatology and laser skin care. Shes the ideal primary care doctor if you wish to feel and look younger.
Many patients prefer having a primary care physician who is an internal medicine doctor, or internist, rather than a general family doctor, because internal medicine doctors have special training to deal with the challenging conditions and illnesses that affect adults as they age. High blood pressure, cholesterol, hormone imbalances, testosterone deficiency, adult growth hormone deficiency, adrenal and thyroid disease, menopause, diabetes, obesity, allergies, arthritis, skin problems, and premature aging are the more common issues that an internal medicine physician like Doctor Sarah treats.
I wish to partner with you in keeping optimal health and minimizing the risk of age related diseases. My goal is to provide innovative, high quality and personalized care in a compassionate atmosphere where the priority is the patient. I encourage patient education and informed life style changes.
Sarapy Clinic – Hormone Replacement Therapy & Medical …
Masculinizing hormone therapy – About – Mayo Clinic
Masculinizing hormone therapy is used to induce the physical changes in your body caused by male hormones during puberty (secondary sex characteristics) to promote the matching of your gender identity and body (gender congruence). If masculinizing hormone therapy is started before the changes of female puberty begins, female secondary sex characteristics, such as the development of breasts, can be avoided. Masculinizing hormone therapy is also referred to as cross-sex hormone therapy.
During masculinizing hormone therapy, you'll be given the male hormone testosterone, which suppresses your menstrual cycles and decreases the production of estrogen from your ovaries. Changes caused by these medications can be temporary or permanent. Masculinizing hormone therapy can be done alone on in combination with masculinizing surgery.
Masculinizing hormone therapy isn't for all transgender men, however. Masculinizing hormone therapy can affect your fertility and sexual function and cause other health problems. Your doctor can help you weigh the risks and benefits.
Mayo Clinic's approach
Masculinizing hormone therapy is used to alter your hormone levels to match your gender identity.
Typically, people who seek masculinizing hormone therapy experience distress due to a difference between experienced or expressed gender and sex assigned at birth (gender dysphoria). To avoid excess risk, the goal is to maintain hormone levels in the normal range for the target gender.
Masculinizing hormone therapy can:
Although use of hormones is currently not approved by the Food and Drug Administration for treatment of gender dysphoria, research suggests that it can be safe and effective.
If used in an adolescent, hormone therapy typically begins at age 16. Ideally, treatment starts before the development of secondary sex characteristics so that teens can go through puberty as their identified gender. Hormone therapy is not typically used in children.
Masculinizing hormone therapy isn't for everyone, however. Your doctor might discourage masculinizing hormone therapy if you:
Talk to your doctor about the changes in your body and any concerns you might have. Complications of masculinizing hormone therapy include:
Evidence suggests no increased risk of breast or cervical cancer.
The evidence that masculinizing hormone therapy increases the risk of ovarian and uterine cancer is inconclusive. Further research is needed.
Because masculinizing hormone therapy might reduce your fertility, you'll need to make decisions about your fertility before starting treatment. The risk of permanent infertility increases with long-term use of hormones, especially when hormone therapy is initiated before puberty. Even after discontinuation of hormone therapy, ovarian and uterine function might not recover well enough to ensure that you can become pregnant.
If you want to have biological children, talk to your doctor about egg freezing (mature oocyte cryopreservation) or embryo freezing (embryo cryopreservation). Keep in mind that egg freezing has multiple steps ovulation induction, egg retrieval and freezing. If you want to freeze embryos, you'll need to go through the additional step of having your eggs fertilized before they are frozen.
At the same time, while testosterone might limit your fertility, you're still at risk of pregnancy if you have your uterus and ovaries. If you want to avoid becoming pregnant, use a barrier form of contraception or an intrauterine device.
Before starting masculinizing hormone therapy, your doctor will evaluate your health to rule out or address any medical conditions that might affect or contraindicate treatment. The evaluation might include:
You might also need a mental health evaluation by a provider with expertise in transgender health. The evaluation might assess:
Adolescents younger than age 18, accompanied by their custodial parents or guardians, also should see doctors and mental health providers with expertise in pediatric transgender health to discuss the risks of hormone therapy, as well as the effects and possible complications of gender transition.
Typically, you'll begin masculinizing hormone therapy by taking testosterone. Testosterone is given either by injection or by a patch or gel applied to the skin. Oral testosterone or synthetic male sex hormone (androgen) medication shouldn't be used because of potential adverse effects on your liver and lipids.
If you have persistent menstrual flow, your doctor might recommend taking progesterone to control it.
Masculinizing hormone therapy will begin producing changes in your body within weeks to months. Your timeline might look as follows:
After masculinizing hormone therapy, you'll meet regularly with your doctor. He or she will:
After masculinizing hormone therapy, you will also need routine preventive care if you have not had certain surgical interventions, including:
When undergoing cervical cancer screening, be sure to share that you're on testosterone therapy and make sure that the gender designation on your sample is disregarded. This kind of therapy can cause your cervical tissues to thin (cervical atrophy), which might mimic a condition in which abnormal cells are found on the surface of the cervix (cervical dysplasia).
Aug. 31, 2017
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Masculinizing hormone therapy – About – Mayo Clinic
Advanced Hormone Solutions
I went in to premature menopause in 2008 and I was 38 years old at that time. My OB/GYN put me on HRT but after one year and a half, I started having palpitations and dizziness. After so medical tests, my doctors decided not to give me their HRT any longer. My OB/GYN strongly suggested to me not to take any oral hormones and I follow that recommendation for 8 years until I realized that my marriage was suffering because my libido was inexistent and having intercourse was extremely painful. That was not a good combination and I decided to start looking for getting help. I had other symptoms but after 8 years in menopause, those were manageable. So, I did some research and found Dr. Matos. Now, after two pellet therapies and a 4-week booster, I feel like a teenager. Sounds funny but it is true. Dryness is gone for good and my libido is back. I am sleeping at least 7 hours every day, I am gaining more energy, and my memory is getting stronger. Last week, I got my second pellet therapy and I have never been so excited to go to a doctors appointment in my entire live.This treatment works perfectly fine and I am encouraging my husband to give it a try.Thank you, Dr. Matos.
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Advanced Hormone Solutions
Hormone Replacement Clinic NY, Testosterone Injections for …
You may be reading this because you are not your normal self. Youre lethargic and your energy level is not what it was. Your body is becoming soft and flabby and youre having problems with focus and concentration. Your sex drive is down and you may be having difficulties achieving an erection. Low Testosterone or a Low T count may be responsible, and Hormone Replacement Therapy may be right for you.
According to the US Food and Drug Administration (FDA), 4 to 5 million American men may suffer from low testosterone, but only 5% are currently treated. What about the remaining 95%? Could you be one of them?
If you answered yes to more than half of these questions, chances are your testosterone levels are less than optimal and you may be deficient and benefit from Hormone Replacement Therapy. You may be going through the male menopause, a condition known as andropause.
Andropause refers to a set of gradual physical and psychological changes that men generally go through. Every man experiences a decline in bio-available testosterone but some mens levels dip lower than others.
Testosterone begins to decline in men at about age 25. Testosterone levels decline gradually over the years and because it comes on slowly, most men often accommodate to the symptoms and do not realize how much they have lost.
Look at the chart to the right. Where on that testosterone level down turn do you think you are?
Many men, after 35 or so, often have a hard time rising to the occasion and challenge of daily stress. It has only been recently that andropause has received attention and recognition, but why the holdup?
Doctors and scientists are well aware of the ramifications due to the absence of estrogen and progesterone in women. In the mean time, men have kept their focus from themselves and their own hormonal induced weaknesses. Why?
At CORE Medical New York our patients talk openly about their problems and what they are going through. But each of them would also admit that they had difficulty making that first call and that they still cannot admit or talk to their friends about their dysfunctions associated with low testosterone.
Men who receive testosterone therapy consequently report that they feel sexier, stronger and healthier. They say that it makes them feel as they did when they were in their prime.
Testosterone Treatments may stop and reverse the physical decline that robs men of their energy, strength and libido. Testosterone can restore muscle tone and improve stamina. Testosterone can restore healthy sexual excitement and desire, which in turn, results in an improvement in mood and overall well being.
Restoring testosterone to youthful levels with testosterone replacement can reverse the situation. All too often, men automatically assume that as they age, their sexual capacity will diminish. There is no need to accept this loss of sexuality. We should be able to live our life with the same excitement and enthusiasm we enjoyed during our youth.
Potential Testosterone Therapy results:
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Hormone Replacement Clinic NY, Testosterone Injections for …
Masculinizing hormone therapy – Care at Mayo Clinic – Mayo …
Mayo Clinic's approachTeamwork
The Transgender and Intersex Specialty Care Clinic (TISCC) provides integrated medical, psychosocial and surgical intervention to individuals with gender dysphoria or incongruence and to those with disorders of sexual development. The team includes providers from various specialties including endocrinology, pediatric endocrinology, social work, psychiatry, psychology, voice therapy, gynecology and plastic surgery.
Treatments offered include:
Before you start treatment, you will meet with at least one member of the TISCC medical team a doctor or nurse practitioner and a member of the TISCC mental health team, such as a social worker, psychologist or psychiatrist. You'll have a complete medical evaluation to make sure that your treatment risks are identified and addressed. Evaluation of your mental health ensures that any mood or mental health concerns are reasonably well-managed before you start the hormone therapy.
Each person is different. Your providers will look at your specific case in order to come up with the best recommendations for you. Your health care team will work with you during your treatment and make sure your expectations are realistic. Your team wants to make sure your goals are being met, any risks are managed and your questions are answered.
Mayo Clinic specialists are committed to providing the latest, most comprehensive treatment options for gender dysphoria. Your Mayo Clinic specialist's advice about the best treatment for you will be based on expert knowledge of and experience with all treatment options for gender dysphoria.
At Mayo Clinic, endocrinologists, psychiatrists, psychologists, nurse practitioners, social workers and surgeons work together to provide exactly the care you need.
Having all of this expertise in a single place, focused on you, means that you're not just getting one opinion your care is discussed among the team, your test results are available quickly, your appointments are scheduled in coordination and highly specialized experts are all working together to determine what's best for you.
Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.
For more information on visiting Mayo Clinic, choose your location below:
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.
In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
Learn more about appointments at Mayo Clinic.
Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.
Aug. 31, 2017
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Masculinizing hormone therapy – Care at Mayo Clinic – Mayo …
Medical & Mental Health Resources | LGBTQ
Transgender MedicalTrans Health: http://www.trans-health.comInformation on health clinics, resources, and organizations.
Transgender Care: http://www.transgendercare.comOlder website, but it has some good information on medical and surgical practices.
Hudsons FTM Resource Guide: http://www.ftmguide.org/Terrific resource for all things FTM. Presenting, clothing, grooming, hormones, and surgery are all covered on this site.
TRANSGENDER Therapists, and Medical Doctors, and Psychiatrists
New Jersey:
Donna German Klein, MSW, LCSW268 Green Village RoadGreen Village, New Jersey 07935(973) 816-2920
Cameron MazzeoLGBT SpecialistMarkell Counseling74 Route 9 North, Suite 7Marlboro, NJ 07726phone: (732) 817-0103fax: (732) 817-0105
Karla Morse, MA, LPC, ACSMindful Therapy Center105 Evesboro-medford RdSuite MMarlton, New Jersey 08053(856) 302-0542 x7011I have worked with transgendered individuals as a specialty since 2004 and multicultural couples, families and groups since 1998.
Dr. Donna LobiondoPsychoforensics, LLC39 South Fullerton AvenueMontclair, New Jersey 07042(973) 968-5257
Jennifer Whitlock, LPC93 Main Street, Ground Floor (Also called Route 206)Newton, NJ. 07860Phone : (973) 222-3750Fax : (718) 992-9770Email : email@example.com : http://www.jenwhitlock.com/"I welcome the Gay, Lesbian, Bisexual, Transgender and Questioning population. Homosexuality is not a problem that must be cured, but there are challenges unique to people with alternate lifestyles. I can help people come out to loved ones, deal with harassment or merely discuss relationships without having to change the pronoun. I have advocated for transgender clients who have chosen to make transitions, and those who have decided to not make full transitions. I have run a support group for Male to Female (MtF) individuals, using psychodramatic action methods."
Margie NicholsInstitute for Personal Growth281 Pavonia AvenueJersey City, NJ. 07302Phone : (800) 379-9220Fax : (732) 246-8081Email : email@example.com : http://www.ipgcounseling.com
Lisa O'Connor, MDHealthy Transitions LLC1390 Valley Road, Suite 1BStirling, NJ. 07980Phone : (908) 647-1688Fax : (908) 647-5180Ofice Managers Email : firstname.lastname@example.com : http://www.healthytransitions.mdMedical management: Hormone Replacement Therapy (HRT), Appropriate medication for mental health issues. Pre- and Post-Operative (GRS) care for TG clients. Pre-op Evaluation/letters: First and Second letters. Providing health care and mental health providers across the country with assistance on the appropriate care of all clientele under the gender umbrella. This includes assessment/diagnosis, appropriate hormone therapy, labs, as well as psychotherapy for the pre and post-operative transsexual. Dr. O'Connor is a voting member of The World Professional Association for Transgender Health (WPATH). Member of the American Medical Association (AMA). Member of the World Association for Sexual Health. On the Board of Directors of the Alliance for Gender Awareness (AGA). A Diplomat with the American Academy of Family Physicians (AAFP).
Dr Nina Williams, Licensed Psychologist5 Rosewood CourtSomerset, NJ. 08873Phone : (732) 800-4796Email : email@example.com
Dr. Andjelka (Angie) Stones, Ph.D., MAPA, MAPS860 Lower Ferry Road, Suite 1Ewing, NJ. 08268Phone : (609) 403-8740 x113Email : firstname.lastname@example.com : http://www.globalnewworld.com"I specialize in Gay Parenting advice, pre and post becoming parents as well as Transgender pre and post op guidance. I have offered my services in Spain, UK and Sweden and currently teach Gender Psychology (among other subjects) on Graduate level. My services are flexible in respect of mode of contact as I work face to face, on Skype and via email."
Catherine B. Wetzell, MA, LPC, NCCEmail : email@example.com N. Smith, MSW, LSWEmail : email@example.com Washington Ave, Suite 2BNewtown, PA. 18940Phone : (215) 932-9904andMontgomery Knoll148 Tamarack CirclePrinceton, NJ. 08558http://www.healingrecoveryarts.com/
Catherine B. Wetzell, MA, LPC, NCCEmail : firstname.lastname@example.com N. Smith, MSW, LSWEmail : email@example.com Washington Ave, Suite 2BNewtown, PA. 18940Phone : (215) 932-9904andMontgomery Knoll148 Tamarack CirclePrinceton, NJ. 08558http://www.healingrecoveryarts.com/
New York:
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Dr. Janet Finell41 5th AvenueNew York, New York 10003(646) 351-1724As a psychologist and psychotherapist, I focus on gender and sexuality, work and intimacy issues. I interweave cognitive-behavioral-dynamic approaches and tailor them to the individual's needs. I use an interactive-here-and- now approach in assisting people toward developing their strengths and skills in the areas in which they're seeking help. General Concerns: Anxiety, Depression, Sexuality, Gender issues, Body-issues; self-esteem: coping skills. Client focus: Adults preferred: Individuals and couples.
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Katherine Rachlin, Ph.D.49 West 24 ST.Ste. 901New York, NY 10010Phone : (212) 206-3636Email : email@example.com : http://www.transgendertherapyny.com/Licensed Clinical Psychologist, Gender specialist, Certified Sex TherapistKatherine Rachlin, Ph.D. is a psychotherapist in private practice in New York City. She has special expertise in working with people who have concerns regarding gender identity and sexuality. Dr. Rachlin is an interactive, solution-focused therapist. Her therapeutic approach is to provide support and practical feedback to help clients effectively address personal life challenges. She integrates complementary methodologies and techniques to offer a highly personalized approach tailored to each client. With compassion and understanding, she works with each individual to help them build on their strengths and attain the personal growth they are committed to accomplishing.
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Callen Lorde356 W 18th StNew York, NY 10011Phone: (212) 271-7200Fax: (212) 271-7225Callen-Lorde Community Health Center provides sensitive, quality health care and related services targeted to New Yorks lesbian, gay, bisexual, and transgender communities in all their diversity regardless of ability to pay. To further this mission, Callen-Lorde promotes health education and wellness and advocates for gay, lesbian, bisexual, and transgender health issues.http://www.callen-lorde.org
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Medical & Mental Health Resources | LGBTQ
Hormone Replacement Therapy – webmd.com
A few years ago, the use of hormone replacement therapy (HRT) looked like a medical mess. For decades, women were told that HRT — usually a combination of estrogen and progestin — was good for them during and after menopause. Then the 2002 results of the Women's Health Initiative study seemed to show just the opposite: hormone replacement therapy actually had life-threatening risks such as heart attacks, strokes, and cancer.
"Women felt betrayed," says Isaac Schiff, MD, chief of obstetrics and gynecology at Massachusetts General Hospital in Boston. "They were calling their doctors, saying, 'How could you put me on this drug which causes heart attacks, strokes, and cancer?'"
Almost overnight, standard medical practice changed. Doctors stopped prescribing hormone replacement therapy and 65% of women on HRT quit, according to Schiff.
But some experts say hormone replacement therapy may be coming back. All along HRT remained an important treatment for menopause symptoms like hot flashes. And now, a number of recent studies show that hormone replacement therapy may have protective benefits for women who are early in menopause.
"I think we swung too positive on hormone therapy in the past and then we went too negative," says Schiff, who is also chair of the American College of Obstetricians and Gynecologists Task Force on Hormone Therapy. "Now we're trying to find a balance in between."
"We're definitely in a gray zone of uncertainty about hormone therapy," says Jacques Rossouw, MD, project officer for the federal Women's Health Initiative (WHI). "But when you're uncertain, you have to err on the side of safety."
While Rossouw concedes that new studies show some preventative benefit for younger women, he says any potential benefit is very slight. And, he notes, there is no evidence that any benefit would last if women kept taking hormones as they got older.
But increasing numbers of researchers say there should be a place for hormone replacement therapy as a preventive treatment for limited periods as it may help prevent disease in younger women around the age of menopause.
"We have evidence that hormone therapy can prevent heart disease, hip fractures, and osteoporosis, and that it cuts the risk of developing diabetes by 30% in younger women," says Shelley R. Salpeter, MD, a clinical professor of medicine at Stanford University's School of Medicine.
In one recent study, Salpeter and her colleagues found that HRT reduced the number of heart attacks and cardiac deaths by 32% in women who were 60 or younger (or women who had been through menopause less than 10 years ago). In older women, hormone replacement therapy seemed to increase cardiac events in the first year, and then began to reduce them after two years.
The 32% drop is significant, but perhaps not as dramatic as it sounds. In hard numbers, Salpeter estimates that of women aged 50 to 59 who don't get hormone replacement therapy, about 7 out of 4,800 will have a cardiac event in one year. With HRT, 3 out of 4,800 will have a cardiac event.
Salpeter's study indicates something crucial: The age at which a woman starts HRT may make a big difference.
Salpeter argues that when a person first starts hormone replacement therapy, her risk of blood clots increases slightly. In healthy women who are in their 50s — and close to the age of menopause — this increase is very unlikely to cause problems. The higher risk subsides after a couple of years, she says, although other experts disagree.
But women in their 60s may be more likely to already have early heart disease or hardening of the arteries (arteriosclerosis). In these cases, the risk of blood clots becomes more serious. So if a woman first starts hormone replacement therapy in her 60s, the initial risks are more dangerous, Salpeter says.
This is what Salpeter says affected the results of the Women's Health Initiative trial. The average age of a woman in that trial was 63, with a range of ages between 50 and 79. She and other critics argue that the researchers were looking at many women who might already have been sick.
"I was surprised when I first heard the [WHI] results," says Lynne T. Shuster, MD, director of the Women's Health Clinic at the Mayo Clinic in Rochester, Minn. "But, once I saw the details, I wasn't surprised anymore. They gave women who were older and possibly had underlying arteriosclerosis a pill that increased the risk of blood clotting. Of course it increased the risk of heart problems."
Shuster and Salpeter argue that those results have no bearing on whether younger, healthy women in their 50s would benefit from HRT.
"Basically, [the WHI researchers] were looking at the wrong group of people," Salpeter tells WebMD.
Rossouw defends the WHI study design. "We were specifically testing the hypothesis that hormone therapy would help protect older women against disease," Rossouw tells WebMD, "The results were absolutely clear: They do not."
Media reports on the WHI results may have given people inflated fears of hormone replacement therapy's risks, the doctors say.
For example, the Women's Health Initiative results showed that combined hormone replacement therapy seems to increase the risk of breast cancer by 33%, Schiff says. That's a serious increase. Still, the risk to any one woman is not as high as it sounds, Schiff says.
"According to the WHI, without hormone therapy, 3 of every 1,200 women aged 55 to 59 will develop breast cancer this year," says Schiff. "With hormone therapy, 4 out of 1,200 will. It's a 33% increase, but the absolute risk is still very, very small."
Shuster points out that other behaviors — like drinking two glasses of wine a night — also increase breast cancer risk by a similar amount.
Women who take estrogen alone — a treatment only available to people who have had a hysterectomy — appear to have a lower risk of developing breast cancer than women who take progestin and estrogen together. In a 2006 JAMA article, researchers from the Women's Health Initiative found that after about seven years of treatment with estrogen, there seemed to be no increased risk of breast cancer.
However, estrogen-only therapy may have long-term risks. A May 2006 study published in the Archives of Internal Medicine found using estrogen-only therapy for 20 years or more showed increased risk of developing breast cancer.
As HRT is being re-evaluated — and new evidence is coming in — it's difficult to know who should get hormone replacement therapy and for how long.
The U.S. Food and Drug Administration (FDA) recommends that HRT should be used in women who have severe menopausal symptoms.
"Estrogens are the best agents we have for the relief of menopausal symptoms like hot flashes, vaginal dryness, and loss of sexuality," says Schiff. They're also a good treatment for menopausal symptoms that are often not recognized: Difficulty sleeping, stiffness, joint pain, and mood changes.
But for disease prevention — lowering the risk of heart attacks, strokes, and most cases of osteoporosis — the FDA still does not recommend hormone replacement therapy.
"We have other ways of cutting the risks of heart attacks and strokes," Schiff tells WebMD, including better diet, exercise, and other medicines.
Will HRT ever again be used as prevention for these serious diseases? Only time and research will tell. The experts remain divided.
"I believe that studies in the next few years will support using hormone therapy in younger women [closer to the onset of menopause] for prevention," says Shuster. "But "we don't have all the information yet."
Another big question is how long hormone replacement therapy can be used safely. It was once thought that using it for five years or less to relieve menopausal symptoms had no risks. But the WHI study seemed to show that was not the case.
There are still a lot of unknowns. Many women now take doses of hormones that are lower than the ones used in the WHI trial. Hormones are also delivered not just through pills, but in other forms, like skin patches. We don't know yet whether these lower concentrations and different forms might decrease the risks.
For now, the FDA recommends that women who take hormone replacement therapy for menopausal symptoms take the lowest effective dose and for the shortest time period to alleviate symptoms.
With all of the contradictory messages, it's hard for a woman to know what to do. There's also a lot of lingering anger about what happened in the wake of the Women's Health Initiative results.
"I lost a lot of faith in my doctors after that," says April Dawson, a 63-year-old Connecticut woman who used hormone replacement therapy for about a year. "And all of the women I know feel the same way.
"In the first place, I didn't like the idea of going on medication when I didn't have any symptoms," Dawson tells WebMD. "But I feel like my doctors ganged up on me and pushed me to take it."
Today, doctors are far more likely to tell each woman that she must make the decision herself, weighing the pros and cons of hormone replacement therapy, considering her symptoms, family history, lifestyle, and risk of disease.
If you take HRT, keep in mind that the absolute risks are low. But you should still regularly check in with your doctor. Ask if there is any new information that might cause you to rethink your decision.
"Hormone therapy is a field that continues to change rapidly," says Shuster. "Treatment has to be more individualized than ever. Women are seeking the one right answer, but for now, we just don't have one."
SOURCES: American College of Obstetricians and Gynecologists web site,"Frequently Asked Questions about Hormone Therapy, "News release: ACOG IssuesState-of-the-Art Guide to Hormone Therapy." Chen, WY et al, Archives ofInternal Medicine, May 8, 2006; vol 166: pp1027-1032. April Dawson,Milford, Conn. Jacques Rossouw, MD, project officer for the Women's HealthInitiative at the National, Heart, Lung and Blood Institute, Bethesda, MD.Salpeter, SR et al, JGIM, July 2004; vol 21: pp 363-366. Salpeter, S,Climacteric 2005; vol 8: pp307-310. Salpeter, SR et al, Diabetes,Obesity and Metabolism, in press. Salpeter, SR et al, Journal ofGeneral Internal Medicine, July 2004; vol 19: pp 791-804. Shelley R.Salpeter, MD, clinical professor of medicine at Stanford University's School ofMedicine. Isaac Schiff, MD, chief of obstetrics and gynecology at MassachusettsGeneral Hospital in Boston; chair of the American College if Obstetricians andGynecologists Task Force on Hormone Therapy. Lynne T. Shuster, MD, director ofthe Women's Health Clinic at the Mayo Clinic in Rochester, MN. Stefanick, ML etal, JAMA, April 12, 2006; vol 295: pp 1647-1657. U.S. Food and DrugAdministration web site, "Questions and Answers for Estrogen and Estrogen withProgestin Therapies for Postmenopausal Women."
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Hormone Replacement Therapy – webmd.com
Clinic North Vancouver | Bioidentical Hormone Treatments
Our goal is to help you to improve your health and quality of life, while identifying the possible cause of your symptoms. We strive to offer you the best care possible in a professional, spa-like space and support you through the latest Naturopathic Medical practices.
Are you suffering for a health condition you need help treating? Are you generally healthy but have noticed increasing difficulty with your weight, mood, energy, focus or hormones? Thepractitioners at Marine Drive Naturopathic Clinic offer programs and treatments to help you not only to feel better, but examine the cause of your symptoms or conditions.
Our team includes Naturopathic Physicians Dr. Cathryn Coe,Dr. Cameron McIntyre, Dr. Elizabeth Miller, Dr. Lynn Klassen, and Dr. Sarah Wulkan.
Weight gain? Hot flashes? Poor sleep? We offer comprehensive thyroid and hormone testing to identify hormonal imbalances, correcting them using bioidentical hormone treatments or herbal support
Are you or your child affected by learning difficulties or cognitive problems? We offer testing and treatment for conditions such as autism spectrum disorders, Alzheimers disease and dementia, and ADD/ADHD. Our Clinical Counsellor also offers support forparents of children with autism and spectrum disorders
The clinic is conveniently located along Marine Drive in North Vancouver with plenty of free parking and direct access to public transit. Come in, relax, enjoy a cup of tea and read a magazine in our spa-like environment. At Marine Drive Naturopathic Clinic, your treatment begins the minute you walk in the door
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Clinic North Vancouver | Bioidentical Hormone Treatments
Medical Weight Loss – Hormone Replacement Therapy and HCG …
Medical Weight Loss Programs
If you consider yourself overweight, odds are that you have tried diet and exercise routines but have, at some point, found them lacking in terms of results.
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The thyroid is the master gland in the body, and it can significantly impact weight gain, as well as the immune system, fertility, motivation and other important aspects
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Insulin is a hormone made in the pancreas, an organ located behind the stomach. The pancreas contains clusters of cells called islets. Beta cells within the islets make insulin and release it into the blood.
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PCOS is a weight gaining condition that can manifest in numerous ways. As such, the females who experience this condition almost never have the same combination
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Migraine headaches in women usually go hand in hand with other female problems like PMS, uterine fibroids, ovarian cysts, irregular and painful periods cystic acne, facial hair, infertility, post-partum depression and various cancers
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Does the HCG really work for weight loss ? absolutely it does. But with new web sites appearing daily offering a wide range of HCG diet products, from prescription shots to homeopathic supplements
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Hormone replacement therapy is not a necessity for everyone, though. The professionals at Medical Weight Loss certainly offer this treatment to all clients who would benefit from it.
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The pure biologically identical (human identical) hormone is either extracted from plants or synthetically manufactured. What is most important
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Medical Weight Loss – Hormone Replacement Therapy and HCG …
Kate's morning sickness probably not dangerous, doctors say – CBS News
Last Updated Sep 5, 2017 2:06 PM EDT
Along with the announcement that Britain's Prince William and his wife, the Duchess of Cambridge, are expecting their third child, the couple revealed that for the third time as with her previous two pregnancies the former Kate Middleton is suffering from hyperemesis gravidarum, or severe morning sickness.
Hyperemesis gravidarum is estimated to affect about one to three percent of pregnant women and can result in nausea and vomiting so acute that hospitalization is required. It is thought to be caused by pregnancy hormones, but doctors aren't sure why some women experience worse symptoms than others.
The condition usually begins in the early weeks of pregnancy and in many cases, subsides by about 20 weeks. But for some women, the effects may persist until the baby is born.
The condition can be "absolutely devastating," said Dr. Roger Gadsby of Warwick University, who has studied the issue for decades. "Your life is on hold while the symptoms are present," he said, noting that some pregnant women may vomit dozens of times per day and be restricted to bed rest.
Kensington Palace made the pregnancy announcement Monday, saying the duchess was not feeling well enough to attend an official engagement later in the day. Kate is being cared for at her Kensington Palace home in London. Officials did not announce when the baby is due, but the duchess is believed to be less than 12 weeks pregnant.
She and Prince William already have two children: Prince George, 4 and Princess Charlotte, 2.
At a public appearance in Oxford on Tuesday, William said the royal couple is happily anticipating baby No. 3.
"It's very good news," he said, adding, "It's always a bit anxious to start with, but yeah she's very good."
In 2012, Kate was hospitalized for several days when she was believed to be suffering from dehydration during her first pregnancy.
"People can get dehydrated very quickly so [a woman] might need to come in after a day or two," Dr. Jeff Chapa, head of the section of maternal fetal medicine at the Cleveland Clinic, explained to CBS News at the time.
Chapa said virtually all pregnant women experience some degree of morning sickness during the first three months of pregnancy, which is caused by the release of HCG hormone from the placenta. But if a woman can't keep anything down down and feels particularly weak, those are signs that she may need to get evaluated by a doctor for hyperemesis gravidarum.
There is no evidence that the nausea and vomiting from severe morning sickness will affect the baby's future health. Women with the condition actually have a slightly lower risk of miscarriage, according to Britain's Royal College of Obstetricians and Gynaecologists.
In severe cases, however, babies can be born with lower than expected birthweight. Women with the condition are advised to eat small meals often, to avoid any foods or smells that trigger symptoms and to consult their midwife or doctor if their symptoms do not subside.
If treatment requires hospitalization, women are typically given vitamins, steroids and anti-nausea drugs intravenously. Patients are also sometimes treated with shots of heparin, to thin their blood: pregnant women are at increased risk of developing blood clots in their legs, and being dehydrated further elevates the risk.
Gadsby said he would expect doctors to be able to treat the duchess at Kensington Palace and that there shouldn't be any lasting effects. She would likely have to cut back on her royal schedule, though.
"As long as the mom receives adequate treatment, the mom is usually fine and the baby is fine," he said.
2017 CBS Interactive Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.
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Kate's morning sickness probably not dangerous, doctors say – CBS News
4 reasons you should limit your kid's screen exposure – TheHealthSite
If you are travelling by bus or sitting at a doctors clinic, you will see kids playing games on mobiles. The other day I saw my cousins kid spending around 2 hours just sitting on a couch watching videos and playing on phone. If the phone is not available then spending time on acomputer or videos games or television is what most kids resort to. Going outdoors to play is a far fetched idea. One reason why constant exposure to screen or screen-based activities is a really bad idea is that it can impair the brain function and health. Dr Jyoti Chawla, Senior Consultant Paediatrics, Paras Panchkula says that reducing screen-based activities can help to rebalance brain chemistry and improve its function. It is important for children in the modern age to have controlled exposure to screens, in particular through video games, television and now mobile phones. Here are a few reasons why reducing screen based activities in kids is good for the brain health. Here are4 tips to stop your child from watching too much TV.
1. Ensures healthy hormone balance:It is seen the spending time on screen or doing related activities trigger dopamine release, which is the hormone majorly responsible for activating addiction pathways. However, reducing the screen time can help balance the hormones melatonin, which is a hormone essential for good health and well-being. Melatonin also gets converted to serotonin, a hormone necessary for calmness, a sense of well-being, and bonding, and it influences mood and social behaviour.
2. Improves blood flow to the frontal lobe: Critical thinking, creative activities, and sports improve frontal lobe blood flow, whereas screen activities tend to localize blood flow to the more primitive areas of the brain. This is not only bad for adultsbut also for children. These shifts in the blood flow can be devastating over time and may impact the development of the brain permanently. Read about whats the right age to give your child a smartphone?
3. Reduces stress hormones: Screen activities are associated with the stress response. This means fight-or-flight hormones are released in the short term, and cortisol, which is known as the stress hormone, is increased over time. Both of these hormonal trends are linked to cognitive, mood and behavioural issues as well as poor physical health.
4. Reduces overstimulation: The brain is not meant to be bombarded with unnatural visual stimulation such as overly bright and intense colors, rapidly shifting scenes, excessive movement, plus the brightness of the screen itself. Moreover, it is also not meant to process man-made electromagnetic fields, which is the case when you spend most of the time on screen. Hence, reducing thescreen exposure can help you to lower the overstimulation to the brain and improve your overall well being.
Also read about reasons why your child is not sleeping tonight!
Image Source: Shutterstock
Published: September 4, 2017 3:00 pm
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4 reasons you should limit your kid's screen exposure – TheHealthSite
Osteoporosis cure? Woman reveals THIS treatment has REVERSED her symptoms – Express.co.uk
Although a fracture is the first sign of osteoporosis, some older people develop the characteristic stooped – bent forward – posture, which can cause people to lose height.
Height is lost as the bone crumbles and vertebrae collapses, and the chest and abdomen capacity decreases, sometimes resulting in difficulty breathing as the ribs end up touching the pelvic bone.
When the bones in the spine have fractured, it can be difficult to support the weight of the body.
However, now a London-based clinic has revealed that a treatment programme can reverse some of the height lost through the common age-related bone disorder.
The London Osteoporosis Clinic uses a combination of drug-therapy, non-drug treatments and lifestyle approaches to help patients.
Anne Torry, a 75-year-old bookkeeper, said her height increased by 3cm following treatment at the clinic.
Unbeknownst to me, I actually managed to fracture two discs in my back getting out of the car in a hurry one day; after dealing with the discomfort and niggling pain for a while, my GP organised an x-ray which showed the fractures, said Anne.
It came as somewhat of a surprise, particularly when my GP suggested that I may have osteoporosis.
I waited patiently for the results, not for a minute thinking that they would be positive.
I was again taken aback when I was told that the fractures were due to osteoporosis and that I would benefit from undergoing treatment.
Anne is among a number of patients at London Osteoporosis Clinic whose treatment programme included the parathyroid hormone Teriparatide, one of the only drugs that can not onlyslow down the progression of osteoporosis, but also help to grow new bone.
Annes bone density is showing an improvement of over 10 per cent per year since starting treatment.
My GP referred me to the London Osteoporosis Clinic, and I met with Dr Taher Mahmud, she said. From the outset, he reassured me and was certain that he could help me.
Even so, when I discovered that I had regained the three centimetres in height that Id lost to osteoporosis, I was amazed. It was the last thing I was expecting.
My day to day life has improved through the treatment programme, and I am now able to live a reasonably comfortable life, managing jobs that may before have been a little more difficult.
The biggest surprise, however, was definitely the increase in my height!
Following a consultation with Dr Mahmud, a diagnosis will be made by examining the results of a bone density (DEXA) scan.
Depending on the stage and severity of osteoporosis, a treatment plan will be put in place, which can range from advice on lifestyle, such as giving up smoking and diet to several drug options, including an 18 to 24 month course of daily injections, prescribed to stimulate cells that create new bone, increasing bone density and replace height lost through the deterioration of bone.
The clinic was co-founded by Dr Taher Mahmud whose mother had osteoporosis. Dr Mahmud co-founded London Osteoporosis Clinic with former General Medical Council president, Sir Graeme Catto.
Initially we thought that Annes increase in height was an anomaly; we didnt expect it to be a regular occurrence in our patients, said Dr Mahmud.
However, in the last week alone, I have seen three further patients who have gained between one and three centimetres in height over the course of one to six months.
My vision was to create a clinic that deals with osteoporosis holistically, and that intervenes early with regards to diagnosis and treatment of this potentially debilitating condition.
Dr Mahmud said more than 8 million osteoporotic fractures occur worldwide- which equates to one every three seconds.
It is not a well-known fact that osteoporosis can be reversed, bone density can be increased, height can be restored and life can go on.
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Osteoporosis cure? Woman reveals THIS treatment has REVERSED her symptoms – Express.co.uk
5 unexpected symptoms of the menopause every woman needs to know about – Netdoctor
Every woman experiences the menopause differently, but many just aren't prepared for the range of symptoms and emotions this life shift can involve.
Oestrogen is the main hormone that reduces during the menopause. It affects many different areas of your body including your brain, so can cause many symptoms when its levels start to naturally fall. And these signs might occur even if you're still having periods. This time, called the perimenopause, can last for several years. It means many women won't make the connection to their hormones and end up suffering in silence.
Dr Louise Newson, a GP who specialises in menopause (and runs a regular private menopause clinic at Parkway Hospital in Solihull), is passionate that this needs to change. She says she is often disappointed about how little accurate information there is for women to learn about the menopause. Which seems silly, considering it's something that's going to happen to all of them.
"Ten years ago if I'd had this conversation I would have said "oh, apart from night sweats and hot flushes, there's not that many other symptoms" but now I've seen hundreds and hundreds of women all telling me about all these other symptoms related to their changing hormone levels. And it's 2017 and many women are having rubbish lives because of it. And it doesn't have to be like this," she says.
Dr Newson wants women to know they're not alone. Here she explains the unexpected symptoms the menopause can cause:
It's often the symptoms people can't see that lead to the most difficulties, says Dr Newson.
Feelings of depression and low self-esteem, anxiety and panic attacks are very common symptoms of the menopause, she reveals. She has seen loads of women who have wrongly been prescribed antidepressants. Many also become fearful of everyday scenarios, she explains:
"I hear from a lot of women who find they're too scared to go into their car or they don't like their husband's driving anymore. They'll say they just worry about things they've never really worried about before."
Anxiety and depression symptoms can be debilitating and impact on work and family life. If you're experiencing anything similar, you should see your doctor.
Think the menopause will finally mean you're free from PMS? Not necessarily unfortunately, says Dr Newson. It's not uncommon for mood swings to appear during this time which can have a big impact on relationships.
"People tell me how cross they get – fed up with their children and fed up with their husbands. They often don't want their partner touching them. When women get better they realise how bad-tempered they've been and how hard it's been for their partner to live with them."
GettyThomas Barwick
It might not be too surprising to learn that sleep becomes harder during perimenopause and menopause. Night sweats are common, of course. But even if you don't experience those, you might be more tired than normal and put it down to an exhausting life perhaps you have a stressful job, or grown up children giving you grief?
Dr Newson says if you can't get through the day without needing a nap, that's a sign you might need some help.
"A lot of people think they're tired because they have a new job or their children are stressing them out. I know myself when I was having symptoms I felt so tired and I just blamed it on work. And now I'm doing more work and I'm less tired! A lot of women tell me they literally come home from work and go straight to bed. Or they have a nap in the afternoon but they've never told anyone because they think it's just what happens when you get a bit older, which is awful," she says.
Falling oestrogen levels affect the joints in numerous ways making movement feel stiffer and more painful for some people. But many women will be misdiagnosed with arthritis when it's likely related to depleting hormones. It also means women are likely to stop exercising, even if they used to enjoy it before, potentially making other symptoms worse, says Dr Newson.
We're not very good at talking about bladders, but if you're going through the menopause or perimenopause, you might find you're getting up more frequently to pee in the night or even experiencing bladder weakness. Dr Newson explains it's because oestrogen affects the pelvic floor and bladder too.
"Often someone just wouldn't think to trouble the doctor because everyone knows your bladder gets a little bit weaker as you get older. And it's embarrassing if you cough and sneeze and get a little bit of wee in your pants. You likely wouldn't talk to your friends about it, even though your friends are probably suffering the same."
Dr Newson's advice is clear, if you're experiencing any of these symptoms, there are a range of treatment options, so make an appointment with your GP.
Dr Louise Newson has been working with Menopause & Me – a new website dedicated to supporting women throughout their menopause journeys.
Excerpt from:
5 unexpected symptoms of the menopause every woman needs to know about – Netdoctor
SBS show The Obesity Myth is breaking down stigma – The Weekly Review
Photo: supplied
Obesity is a predominantly genetic disease, rather than a lifestyle choice thats the central premise of a new SBS show calledThe Obesity Myth.
The show, which followed doctors and patients at the University of Melbournes Austin Health forsix months, aimsto dispel the stigma attached to obesity.
Austin Healths Weight Control Clinic head professor Joseph Proietto says obese people face constant discrimination.
There is a lot of misunderstanding and misinformation about obesity in the community its an injustice, he says.Gluttony is seen as sinful, and to commit a sin you have to use free will. So the idea has been that people choose to be fat.
The world-renowned obesity management expert says he hopes the program will show obesity is far more complicated than generallythought.
Recent research has revealed how the body regulates weight through the hormones leptin (which decreases appetite) and ghrelin (which increases it). Whenpeople lose weight, their leptin levels decreaseand their ghrelin levels increase.
In 2011, Austin Health discovered levels of otherhormones also change according to weight gain or loss, and that those changes are enduring. Proiettosays this evidence points strongly to weight gain being genetic.
Finding that hormone changes after weight loss are long-lasting showed us that medication needs to be life-long, he says. Obesity is a chronic condition.
In 2014, another of the clinics studies showed the rate of weight loss did not affect how quickly weight was regained, and that more people succeeded in a rapid weight-loss program than a gradual program.
Professor Joseph Proietto. Photo: SBS
To combat obesity in patients, the clinics physicians conduct a thorough history and targeted examination, then offer a partial, very-low-energy diet thatreplaces breakfast and lunch.
After theyve lost all the weight they want to lose, whether it takes three months, six months or a year, then we wean them off the diet and back onto things like carbs and fruit, Proietto says.
A dietician will outlinea balanced, energy-reduced diet, and the clinic will continue to follow the patientsprogress. If theyre struggling to keep weight off because of increased hunger, medication is prescribed.
Proietto hopes the clinics research intoobesity will become common knowledge.
GPs are getting better at treating this condition than they used to be, he says. Hopefully they will continue to educate the public to try to dispel this myth.
If youre struggling with obesity Proietto says not to beat yourself around the head, because its probably genetic. He suggests seeking medical assistance.
Speak to your doctor about it, and see if you can get some help, he says.
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SBS show The Obesity Myth is breaking down stigma – The Weekly Review
How Can a Hormone Imbalance Cause Anxiety? – Calm Clinic
Anxiety is seen as a psychological condition, but the causes of anxiety are far more complex. Anxiety can be caused muscle energy – you can genuinely get mental stresses simply because you're not moving your muscles enough. Anxiety can also be caused by nutrition. Anxiety can be caused by thousands of different things.
So it should come as no surprise that hormonal imbalances may cause anxiety as well. The term "hormonal imbalance" has a variety of meanings, but it's also very clear that it can lead to anxiety.
Hormone activity is responsible for a variety of physical and psychological reactions, including anxiety. Anxiety can also affect hormones. Take our free 7 minute anxiety test to score your anxiety symptoms, compare it to others, and find treatment ideas.
Start the anxiety test here.
"Hormonal Imbalance" can be an incredibly broad term – one that in some ways doesn't have a specific meaning. For example, it's possible that your body releases too much thyroid hormone which may trigger panic attacks. It's also possible that stress is causing too much cortisol production, which leads to further anxiety symptoms.
Start by taking my 7 minute anxiety test, since it will give you a snapshot of your anxiety symptoms that can help be used to treat them. Take it here now if you haven't yet.
The key thing to understand about your hormones is that they are responsible for nearly every process in your body, and your body gets used to a very specific amount of each hormone. Any changes in your hormones may create anxiety, for example:
Anxiety is complex enough that it's even possible for stress and anxiety to cause hormonal imbalances that lead to further stress and anxiety. Hormonal imbalances are an issue that can be physical and natural, or caused by stress, or both, and no matter what causes it can lead to anxiety.
It would be impossible to go over each and every example of a hormonal imbalance. Your body has dozens of hormones and many more types of sub-hormones within those hormone groups, and in some ways any imbalance has the potential to lead to anxiety because any imbalance can lead to physical responses that create stress. But a few examples of these hormonal imbalances include:
These are just a few examples of hormonal imbalances that may cause anxiety.
Interestingly, while there is no doubt that hormone problems can cause anxiety and stress, in many cases it is believed that what most hormonal imbalances do is not create anxiety necessarily, but rather make anxiety worse.
This is especially the case with the menstrual cycle. Experts believe that most women that experience anxiety as a result of menstruation often have lower levels of anxiety before their periods, and then when their period comes the changes in emotional sensitivity may lead to strong anxiety sensations.
Hormonal imbalances can affect both men and women, and hormonal imbalances can cause anxiety even if no anxiety is present. But it is likely that many of those suffering from hormonal issues have anxiety or stress already, possibly in a lesser form, and that eventually is what creates further anxiety when hormones are unbalanced.
When hormonal imbalances cause anxiety, curing it completely can be tough. In some cases, you may need to seek out professional assistance, especially if a condition is causing the hormonal issues, such as those caused by the thyroid.
But even if your hormones are causing your anxiety, anxiety reduction tips can still successfully help you cope with that anxiety, and in some cases once your anxiety is reduced, your hormones may even go back to normal.
Hormonal changes can be a problematic anxiety culprit, because they generally can't be cured overnight. If you're suffering from a hormonal imbalance, then you are also likely in need of some type of hormonal care.
There are many things you can do that will help your hormones stay regulated. There are also some herbal remedies that may be useful, depending on the type of condition you have.
The good news is that you can still treat anxiety even if your hormones are causing it, because anxiety is still mental health related, and your own mental strength can help you recover.
I've helped thousands of people with hormonal imbalances overcome their anxiety. As always, I tell them that the most important place to start is with my 7 minute anxiety test. It's a free test that will give you an incredibly valuable snapshot of your anxiety, which you can then use to seek out the right treatment.
If you haven't yet, take the test now.
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How Can a Hormone Imbalance Cause Anxiety? – Calm Clinic
Low-dose hormone therapy improves sleep for newly menopausal women – wreg.com
ROCHESTER, Minn Mayo Clinic researchers say women just entering menopause can get better sleep with the help of low-dose hormone therapy.
The study, published in Menopause: The Journal of The North American Menopause Society suggests 40 to 60 percent of women have issues with sleep and experiences hot flashes and night sweats. This could ultimately lead to further health related problems down the road.
Poor sleep quality over time affects more than just mood, says Virginia Miller, Ph.D., director of Mayo Clinics Womens Health Research Center and the studys corresponding author. Sleep deprivation can lead to cardiovascular disease, among other health risks. There can be serious consequences mental and physical if youre not getting quality sleep over a long period of time.
To ease the symptoms of menopause, researchers looked at two different forms of hormone therapy: oral estrogen and the estrogen patch.
When compared to the placebo group, the participants taking low-dose hormone therapy reported getting better sleep over a four-year period. Researchers said thats twice the improvement of their peers.
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Low-dose hormone therapy improves sleep for newly menopausal women – wreg.com
Parsing Hormone Therapies, Hot Flashes and Sleep in Menopausal Women – PsychCentral.com
Menopause is a challenging time for many women as hormonal changes can create a cascade of physical and mental health issues. Notably, experts explain that between 40 and 60 percent of women in perimenopause and early menopause face issues with sleep because of this physical change.
The majority also report hot flashes and night sweats, which can be disruptive to falling and staying asleep. Sleep deprivation can influence mood and also increase the risk for serious physical health conditions.
In a new study, researchers from the Mayo Clinic found that low-dose hormone therapy may be effective in easing sleep issues in this population. The goal of the study was twofold: find out how two forms of hormone therapy affect sleep quality and assess the ties between hot flashes, sleep quality and hormone therapy.
The study appears in Menopause: The Journal of The North American Menopause Society.
Poor sleep quality over time affects more than just mood, said Virginia Miller, Ph.D., director of Mayo Clinics Womens Health Research Center and the studys corresponding author.
Sleep deprivation can lead to cardiovascular disease, among other health risks. There can be serious consequences mental and physical if youre not getting quality sleep over a long period of time.
The study looked at two forms of hormone therapy oral estrogen (conjugated equine estrogen) and a patch (17 beta-estradiol) to find out how their use affected sleep quality.
The participants were part of the Kronos Early Estrogen Prevention Study, and all were recently menopausal women. The women self-reported on the quality of their sleep using the Pittsburgh Sleep Quality Index. They also recorded the intensity of hot flashes and night sweats during this time.
Study participants were found to have improved sleep quality over four years when using low-dose hormone therapy twice the improvement of those in the placebo group.
Researchers also found that sleep quality improved with changes in hot flashes and night sweats, but Miller said it remains difficult to determine if the low sleep quality is caused by these symptoms or if they are a consequence of poor sleep.
Menopause affects such a large portion of the population, so it is important to keep researching how we can best promote a womans overall health during this phase in her life, Miller said.
Source: Mayo Clinic
Related Articles
APA Reference Nauert PhD, R. (2017). Parsing Hormone Therapies, Hot Flashes and Sleep in Menopausal Women. Psych Central.Retrieved on August 31, 2017, from https://psychcentral.com/news/2017/08/30/parsing-hormone-therapies-hot-flashes-and-sleep-in-menopausal-women/125332.html
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Parsing Hormone Therapies, Hot Flashes and Sleep in Menopausal Women – PsychCentral.com
Hormone therapy improves sleep quality in recently menopausal women – The New Indian Express
Image for representational purpose only.
WASHINGTON D.C.: A low-dose hormone therapy may be effective enough in treating women with sleep issues during perimenopause and early menopause, finds a recent study.
The findings indicated that the women improved sleep quality over four years when using a low-dose hormone therapy twice the improvement of those in the placebo group.
The study's corresponding author, Virginia Miller, from Mayo Clinic's Women's Health Research Center in Minnesota, United States said that poor sleep quality over time affects more than just mood.
Between 40 and 60 per cent of women in peri-menopause and early menopause face issues with sleep because of this physical change and the majority also reports hot flashes and night sweats, which can be disruptive to falling and staying asleep.
"Sleep deprivation can lead to cardiovascular diseases, among other health risks. There can be serious consequences — mental and physical — if you're not getting quality sleep over a long period of time, Miller added.
The goal of the study was two-fold to find out how two forms of the hormone therapy affect the sleep quality and assess the ties between hot flashes, sleep quality and hormone therapy.The team looked at two forms of the hormone therapy one oral estrogen (conjugated equine estrogen) and a patch (17 beta-estradiol) to find out how their use affected sleep quality.The participants were a part of the Kronos Early Estrogen Prevention Study and all were recently menopausal women.
The women self-reported on the quality of their sleep using the Pittsburgh Sleep Quality Index.They also recorded the intensity of hot flashes and night sweats during this time.They also found that sleep quality improved with changes in hot flashes and night sweats.The study appeared in Menopause: The Journal of The North American Menopause Society.
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Hormone therapy improves sleep quality in recently menopausal women – The New Indian Express
Wales' first transgender healthcare clinic set for Cardiff – BBC News
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Transgender people will be able to access specialist healthcare in Wales at a new gender identity clinic to be built in Cardiff.
Health Secretary Vaughan Gething said there had been an increase in demand for services.
The clinic will be supported by a network of GPs, who have a specialist interest in gender care, including hormone replacement therapy.
Equality charity Stonewall Cymru said it was a "big step forward".
Currently, transgender patients in Wales are referred to the Gender Identity Clinic (GIC) in London, adding to the time and cost it takes to access healthcare.
The Welsh Government hopes the new service would mean less travelling, improved waiting times and better user experience.
It will also ensure current clinic capacity is freed up for those requiring more specialised services, as well as shortening the steps between initial referral and beginning treatment.
Crash Wigley, policy and campaigns officer for Stonewall Cymru, said getting the clinic had been a "long fight" for patients to access "potentially lifesaving care" in Wales.
"Before this there was no provision of gender identity services in Wales, so in order to access the care that people needed they had to go through a complicated referral procedure," she told BBC Radio Wales.
"You are talking about having to wait over a year in order to get your referral made.
"One of the things we know is that when people are denied access to care for such long periods of time, as they have in Wales, that takes a significant toll on people's mental health and wellbeing."
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Mr Gething said the service, run by the Welsh Gender Team (WGT), was part of the Welsh Government's commitment to "improving health and wellbeing for all".
He added: "All but the most specialist services will soon be delivered in Wales, closer to people's homes, which will improve access and experience for people needing care.
"I look forward to seeing great improvements to those services."
An interim service is due to be launched in the autumn and the WGT will accept new referrals from the end of March 2018.
The new clinic will initially prescribe medication for Welsh patients undergoing treatment at the GIC, but the unit will also be able to treat those who are currently on waiting lists in London.
Any Welsh patient who prefers to continue their treatment in London will be able to do so.
Alongside the new service, the All Wales Gender Identity Partnership Group will develop a full gender identity service and referral pathway.
Group member Jack Jackson: "I'm delighted to be able to be part of the process and hope I can make some contribution and improve things for the future of transgender services and people in Wales."
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Wales' first transgender healthcare clinic set for Cardiff – BBC News
The IUD That Gives Women Options – WIRED
In a taupe-walled exam room at the Womens Community Clinic in San Francisco, lead clinician Lisa Mihaly plucks a small laminated card from a cabinet. Tethered to the card are three T-shaped IUDs, or intrauterine devicesforms of birth control that are, as the name implies, inserted into a womans uterus to prevent pregnancy for up to 12 years. Mihaly points to each device like friends in a group photo: Paragard, with its thin bands of copper coiled around a white plastic trunk and two arms at attention; Mirena, the first hormonal IUD available in the US; and Skyla, an IUD designed for women who have never had children. But theres one option missing, Mihaly says: a newer model called Liletta.
Liletta, which arrived in the clinics inventory this summer, is a small device that manufacturers hope will make a big difference. Public clinics pay a wholesale price of $336 to $400 for each of the IUDs on Mihalys card. Add in doctors visits for placement and the total cost can exceed $1,000. Liletta's manufacturer hopes to see a wholesale price for public clinics as low as $50.
Price point matters, possibly more than ever before. Under the Affordable Care Act, women rarely pay full price for an IUD because of provisions requiring insurers to fully cover at least one option from each of the 18 FDA-approved birth control methods. But when Donald Trump took office on a promise to repeal the ACA, IUD insertion rates soared as women sought long-term contraceptive solutions.
Though the ACA is safe for now, The Wall Street Journal reported in August that the Trump administration is planning to roll back the birth control requirement, allowing employers to demur based on religious or moral objections. And affordable, accessible birth control will always be a public health concern. In April, Trump signed a law giving states more freedom to restrict their spending of federal money from the Title X program, which supports the clinics that care for women with Medicaid, or no insurance at all, at lower cost.
Politics and pricing aside, the IUD has experienced something of a revival in the United States. For years a negative narrative dogged the devicesin the 1980s, the Dalkon Shield caused infections and even deaths. But new, safe models, including Paragard and Mirena, made it to market and the mainstream. Since 2002, the number of American women using IUDs has roughly doubled every four years. But it remains low, internationally speakingjust 8 percent of reproductive-age American women use an IUD, compared to 20 percent of Belgians and nearly 70 percent of South Koreansbut the trend continues upward.
And why not? The IUD is among the most effective contraceptives, preventing pregnancy in 99 percent of women who use it over the course of a year. The levonorgestrel in hormonal IUDs stops ovulation or thins the uterine lining, so eggs are less likely to implant, and the physical presence of a foreign object often thickens cervical mucus enough to stop sperm. Plus, theyre inserted once and last for years. Theres no room for error. You cant forget to take it, or forget to get the resupplies, says Cynthia Harper, a reproductive health researcher at UCSF. Just set it and forget it.
While many women have now heard of IUDs, few know about Lilettapartly because it's produced by Medicines360, a San Francisco nonprofit edging into a product category long dominated by Bayer, the pharmaceutical giant that makes three of the four hormonal IUDs available in the US. When Mirena received FDA approval in 2000, there wasnt a single other hormonal IUD available in the US. It remained the only option until 2013, when Bayer released Skyla, a model specific for nulliparous women. And in 2016a year after Lilleta earned FDA approvalthe company released its third hormonal IUD, Kyleena.
Bayers IUDs netted the company $900 million in the US in 2016, and theyve been among the companys 15 best-selling drugs for the past decade. It's a big businessand it doesnt look like that will change anytime soon.
Bayer has created a suite of IUDs that target women with different birth control needs: Skyla has a three-year lifetime and lower hormone levels, while Mirena and Kyleena are approved for five-year use with slightly higher doses of hormones. And Skyla and Kyleenas smaller size is aimed at women who havent had children.
The differences arent strictly clinical, though. The timing of Bayers product releases also allowed the company to keep its own patent-protected devices on the market. Drug patents typically last 20 years from the day a company files its application. With IUDs specifically, which bundle a drug (the body of the IUD) with a device (the inserter a doctor uses to place it), there are two ways to restart the patent clock: bring a new IUD through clinical trials or design a new inserter.
So in 2010, Bayer put two new IUDsthen experimental LCS16 and LCS12, now Skyla and Kyleenainto a clinical trial in Europe, North America, and South America. The company could have run each trial for five years so the new offerings would match Mirenas efficacy, but it finalized Skylas data at three, releasing it in 2013, before Mirenas patent ran out in 2015. Kyleena stayed in the same trial for two more years, receiving FDA approval in 2016.
Bayer has made other moves to maintain its market dominance. In 2014, the year before Mirenas first patent expired, the FDA established guidelines for studies to approve a generic form of the device, as it does for many drugs. The agency later withdrew the guidelines, but proposed spending up to $250,000 in grant money for researchers to find ways to evaluate drug equivalence of generic versions of Mirena. In response, Bayer submitted a citizen petition to the FDA, a 10-page statement urging the agency to require that proposed generics undergo comprehensive clinical testing rather than lab experiments to prove equivalence. The company submitted the petition one day before Mirenas patent expiration date.
Citizen petitions allow ordinary people to have input on health policy, but drug companies have historically employed them to discourage generic drug production, says Michael Carrier, an intellectual property lawyer at Rutgers Law School. The petitions are all carefully consideredsafety concerns are nothing to ignorebut the FDA ultimately denies many of the requests that large companies submit. If it really were about safety, Carrier says, then why is the company waiting until the very end?
Bayers petition mentions that the company has been waiting patiently for the FDA to update the guidelines for testing generic forms of the Mirena IUD, and the long timeline has led them to submit a citizen petition. The FDA hasnt issued a final response to Bayers citizen petition, and the agency keeps any inquiries about making a generic product confidential. Bayer did not respond to questions by press time.
Like Mirena, Liletta doesnt have patent protection on its IUD body. And Liletta is closely modeled after the Mirena, although technically its not a generic. Its a hybrid new drug, different enough from Mirena to stand on its own but similar enough to simplify the clinical trials that earned it FDA approval.
Lilettas IUD body was developed in the late 1990s, when Mirena was first approved in Europe. Jean Michel Foidart, an ob-gyn at the University of Liege, in Belgium, loved the concept of the hormonal IUD, but not the cost. The IUD itself is just a tiny piece of plastic, less than a tenth of a gram of hormones, and two small strings for removal. So Foidart figured he and his lab could create a much cheaper alternative. They mimicked Mirenas T-shape and dosed their model with the same hormone, levonorgestrel. An equally effective IUD with a lower price, he hoped, would provide better access to effective birth control.
There appeared to be a need for better and more reliable contraception in the US. In the mid 2000s, American women were largely relying on less-effective birth control methods, says Harper, the health researcher. Half of US pregnancies were unplanned. So in 2009, an anonymous donorsince identified as the Susan Thompson Buffett Foundation, which Warren Buffett runs in honor of his late wifefunneled $70 million to Medicines360 to get a lower-cost IUD available in the US.
It was an ambitious undertaking for the tiny company. In 2009, the entire team of Medicines360 consisted of Victoria Hale and then COO Ahvie Herskowitz. They licensed Foidarts IUD for distribution in the US and the developing world, changed the name from Levosert to the more marketable Liletta, and inworked with the pharmaceutical company Watson (which has since become a part of Allergan) for manufacturing.
Having a deep-pocketed benefactor gave Hale and her team the freedom to spend time and money on development. Andrea Olariu, who Medicines360 brought on as VP of clinical affairs in 2011, first called clinicians to understand where they needed helpprofessors at medical schools, MDs, and nurse practitioners. The final version of Liletta, they hoped, would be more affordable, and a better product too.
No one they spoke to raised many complaints about the IUDs. Instead, their feedback focused on insertion. To insert an IUD, a doctor or a nurse uses a wandlike gadget to guide it. A small tube at one end holds a flattened device, so when a nurse threads the tube into the cervix, then nudges the IUD upward, it unfolds into the uterus. The procedure takes just a few minutes, but speed doesnt mean precision. Clinicians found it hard to tell whether an IUD had fully exited an inserter, and complained that straight, rigid guiding tubes didnt accommodate the diverse geometries of uteruses. So Olariu worked alongside an engineer, Robert Deckman, to design and test 10 or so inserter prototypes. The finished product is about a foot long, with a thin handle at one end and the floppy tube that contains the IUD at the other. It makes like a little dome, says Jessica Grossman, who took over as Medicines360s CEO in 2015, so when you insert it into the cervix it doesn't cause trauma, and then you deploy the IUD in the uterus by pulling down on this, she says, pressing a small slider down with her thumb. The IUD exits the insertion tube with an audible clickso a nurse, who cant see whats happening, knows insertion took place.
With a finalized device in hand, Medicines360 was ready for the trickiest part of its process: clinical trials.
In 2009, Olariu cast a wide net as she began to enroll patients in Lilettas phase 3 safety trial. In 2000, Mirena was approved based on data from Finland and Sweden, and she hoped to include a wider range of patients in Medicines360s trial in America. Our goal was, as much as we could, to mirror the US population, Olariu says.
They extended their age range to include women between 16 and 45, rather than the typical 18 to 35 demographic of contraceptive studies, to recruit more women who had never given birth. And by enrolling 2,000 women from 27 cities around the country, their enrollment reflected the US census pretty closely. Roughly a quarter of participants were overweight or obese women, who often are excluded from these trials as researchers are uncertain of how weight might affect response to hormones.
Liletta received FDA approval for three-year use in February 2015, two months after Bayer submitted its citizen petition to require stringent testing for any generic versions of Mirena. The unresolved petition never caused Liletta any trouble, as its a unique drugthe Liletta IUD releases a slightly different amount of hormone per day (18.6 micrograms to Mirenas 20), and has a custom-designed inserter.
In rolling clinical trials, Liletta has now been approved for four years of contraception, and Medicines360 will submit their data for five-year approval soon. More than 600 clinics stock Liletta, and in two years theyve provided nearly a hundred thousand patients with IUDs, Grossman says. The difference with Liletta is that its much cheaper than the other IUDs, says Kristyn Brandi, an ob-gyn from the American College of Obstetricians and Gynecologists.
With more options becoming available, the American Congress of Obstetricians and Gynecologists maintains that IUDs are one of many good birth control options. There are clearly differences between hormonal and copper IUDs, and even some differences in lower and higher doses of levonorgestrel. But smaller sizing, one of the marketing points for Bayers latest releases, might not make as much of a difference for the majority of women. Some women like the idea that a smaller IUD might be less painful on insertion, but in general all the IUDs are well tolerated, Brandi says.
Lilettas approval might open a faster, easier, and cheaper route to an IUD, particularly for women who are uninsured, as many of the patients who Lisa Mihaly sees are. But the women sitting in the Womens Community Clinic waiting room, like other women around the country, might still lean toward the other options. Say your sister has Mirena, and your best friend uses Skyla, and you see an ad for Kyleena as youre flipping through a magazine while you wait. Its going to be hard to opt for the unfamiliar Liletta. And Medicines360s nonprofit budget doesnt provide for an advertising campaign like the one Bayer once used to offer a free yoga class alongside Break Up With The Pill messaging at Canadian universities.
Since Lilettas initial approval in 2015, Mihaly still hasnt had a patient ask directly for a Liletta IUD. But the devices are in stock, and shes trained to place one as soon as someone is interested. I'm excited that Liletta exists, and that there's another option, she says, because we have, really when you think about it, so few.
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The IUD That Gives Women Options – WIRED