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Bioinformatics and Phylogenetics [electronic resource] :Seminal Contributions of Bernard Moret /
Contributor(s): Warnow, Tandy [editor.] | SpringerLink (Online service).Material type: BookSeries: Computational Biology: 29Publisher: Cham : Springer International Publishing : Imprint: Springer, 2019Edition: 1st ed. 2019.Description: XXV, 410 p. 113 illus., 63 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783030108373.Subject(s): Computer Science | Bioinformatics | Plant genetics | Computer simulation | Computational Biology/Bioinformatics | Plant Genetics and Genomics | Simulation and Modeling | BioinformaticsOnline resources: Click here to access online
Introduction: A Biography of Bernard Moret -- A Review of Approaches for Optimizing Phylogenetic Likelihood Calculations -- Numerical Optimization Techniques in Maximum Likelihood Tree Inference -- High-Performance Phylogenetic Inference -- Hands-On Introduction to Sequence-Length Requirements in Phylogenetics -- Gene Family Evolution – An Algorithmic Framework -- Divide-and-Conquer Tree Estimation: Opportunities and Challenges -- Taxonomic Supertree Construction with incertae sedis Taxa -- Evolutionary Rate Change and the Transformation from Additive to Ultrametric: Modal Similarity of Orthologs in Fish and Flower Phylogenomics -- Ancestral Genome Reconstruction -- Genome Rearrangement Problems with Single and Multiple Gene Copies: A Review -- Computational Models for Cancer Phylogenetics -- Clusters, Trees and Phylogenetic Network Classes -- Advances in Computational Methods for Phylogenetic Networks in the Presence of Hybridization -- A Perspective on Comparative and Functional Genomics -- Integer Linear Programming in Computational Biology: Overview of ILP, and New Results for Traveling Salesman Problems in Biology.
This volume presents a compelling collection of state-of-the-art work in algorithmic computational biology, honoring the legacy of Professor Bernard M.E. Moret in this field. Reflecting the wide-ranging influences of Prof. Moret's research, the coverage encompasses such areas as phylogenetic tree and network estimation, genome rearrangements, cancer phylogeny, species trees, divide-and-conquer strategies, and integer linear programming. Each self-contained chapter provides an introduction to a cutting-edge problem of particular computational and mathematical interest. Topics and features: Addresses the challenges in developing accurate and efficient software for the NP-hard maximum likelihood phylogeny estimation problem Describes the inference of species trees, covering strategies to scale phylogeny estimation methods to large datasets, and the construction of taxonomic supertrees Discusses the inference of ultrametric distances from additive distance matrices, and the inference of ancestral genomes under genome rearrangement events Reviews different techniques for inferring evolutionary histories in cancer, from the use of chromosomal rearrangements to tumor phylogenetics approaches Examines problems in phylogenetic networks, including questions relating to discrete mathematics, and issues of statistical estimation Highlights how evolution can provide a framework within which to understand comparative and functional genomics Provides an introduction to Integer Linear Programming and its use in computational biology, including its use for solving the Traveling Salesman Problem Offering an invaluable source of insights for computer scientists, applied mathematicians, and statisticians, this illuminating volume will also prove useful for graduate courses on computational biology and bioinformatics. Dr. Tandy Warnow is the Founder Professor of Computer Science at the University of Illinois at Urbana-Champaign, where she is also an affiliate in the departments of Mathematics, Statistics, Bioengineering, Electrical and Computer Engineering, Animal Biology, Entomology, and Plant Biology.
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Why take Aspirin from a toothache?
Caries is, unfortunately, a common disease that everyone faces during their life. You can hardly find a person in this world who has never had at least one bad tooth destroyed by this pathology. Despite the tooth enamel is the strongest structure in the human body, it can be easily damaged as a result of abrupt temperature fluctuations, mechanical impact or the destructive activity of specific microorganisms. Oral hygiene can reduce the latter factor drastically. Still, there is no guarantee that your teeth will remain intact lifelong.
When some defects appear in the protective enamel coating, they open to microorganisms abundantly present in the mouth the access to the dentine, a tooth construction material. This is how the carious destruction of a tooth begins. Consequently, a continuously growing hole appears there, and this is, unfortunately, an irreversible process. The only way to stop it is seeking a dentist's help.
In the beginning, caries symptoms are tiny, if any. Over time, however, they become more obvious. Some pain appears. Initially, it's only when there is a contact with something hot/cold/sweet/sour. Later, the pain persists even when the contact is over. Over time, the carious process will inevitably reach the pulp chamber and result in the inflammation of its tissues. This can be very painful!
If the problem remains ignored at the pulpitis stage, the inflammatory process will involve also tissues around the bad tooth – periodontium and periosteum. In this case, you may find that the only possible solution of the problem is the removal of the tooth. Additionally, with periodontitis and periostitis, there is a risk of transferring the infection to other body organs. This can result in sepsis, which is a severe life-threatening condition.
That being said, the toothache is an alert informing you of the urgent necessity to visit a specialist, who can determine a specific diagnosis and perform all the necessary treatment procedures. In many cases, however, setting off for a doctor's office right away is just impossible. The only way out in this case is to find a temporary solution and relieve the torture using some available drugs. For this end, you should have a relevant medicine in your home first aid kit. Most of the time, the first drug people refer to is aspirin. This is a popular non-steroid anti-inflammatory medication. So does in case of toothache aspirin on tooth really help?
How Aspirin Acts?
This organic compound is the oldest non-steroid anti-inflammatory remedy out there. This substance is a chemical modification of salicylic acid, which was first derived as far back as in the middle of the 19th century, when a German chemist Feliks Hoffman synthesized acetylsalicylic acid from salicylic acid. Later, Bayer was the company that patented the new compound under the brand name of Aspirin.
Just like other non-steroid anti-inflammation medicines, including ibuprofen, diclofenac etc., aspirin inhibits the formation of prostaglandins in inflamed tissues, which are responsible for the following symptoms:
- pain;
- swelling;
- fever.
Suppressing these compounds makes, theoretically, the aspirin toothache treatment and the symptom relief possible.
No analgesic can fully stop an inflammation process in a tooth. Applying in case of toothache aspirin on tooth is only a temporary measure too. It just aims at relieving acute symptoms. So toothache means an urgent visit to your dentist.
Can Aspirin Toothache Treatment Really Help?
A good analgesic should be able to suppress the formation of only adverse prostaglandins, which are responsible for swelling and inflammation.
In general, analgesics can be categorized into two groups:
- Non-selective analgesics. They inhibit the formation of all prostaglandins thus relieving pain.
- Selective analgesics. They do not affect benign prostaglandins and cause fewer side effects. They provide a more focused action, which makes their efficiency superior to that of the first group.
Acetylsalicylic acid – based drugs belong to non-selective analgesics. While a good antifebrile remedy, aspirin shows a weak analgesic effect. With toothache, this substance is almost absolutely useless. Given ingesting acetylsalicylic acid can bring highly undesired consequences like damaging the gastrointestinal tract and bronchial spasms, using this remedy for toothache has no sense at all. Along with that, adding certain combined analgesics that contain this compound to your core treatment can bring positive results.
Using aspirin for toothache may have sense only when the inflammatory process is accompanied with fever. Additionally, acetylsalicylic acid should be applied when it is necessary to avoid clotting, as this substance is known to thin the blood effectively.
Possible Side Effects
As aspirin is a rather weak pain killer, it should be used only with mild pains, in which situation, however, no anti-inflammatory remedy is usually needed at all. Nevertheless, aspirin remains a very popular drug. Remember though that the overdose can result in numerous side effects, including:
- Kidney pathologies;
- Liver dysfunctions;
- Brain damage;
- Hyper-sweating;
- Various allergic reactions;
- Anemia (if taken continuously).

subset: commoncrawl


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I Will Follow Tom27/07/2017
On hearing the news of the murder of one of my leaders and mentors, optometrist Tom Little, in Badakhshan Province, Afghanistan, after a medical expedition to Nuristan. Tom had given thirty-seven years of service to the Afghan people, risking his life to provide life when others had evacuated the chaos of war. He and his wife, with their three daughters, served across political, ethnic, and religious boundary lines through a monarchy, a dictatorship, two Communist coups, a Soviet invasion, a mujahedeen civil war, the Taliban, and the current fragile Western-backed government. Tom was killed along with another of my mentors Dan Terry and eight others on 5 August 2010.
The poem is written in an A/A/B/B rhyme scheme at eight syllables per line.
He'll never know the rocking chair
Or nursing home dementia
With body intravenous fed
While fading mind hangs by a thread
Instead this body pierced with lead
Lived very well, though now slumped dead:
A sacrament in flesh and bone
A testament with human tone
"This is my body; this is my blood"
His hands outstretched in brotherhood
Whose parallel in Galilee
Was crucified, nailed to a tree
Greed-struck the robbers lost all sense
With holier-than-thou pretense
Of hand-wrought righteousness they slay
"The better Muslim," Afghans say
A man of peace, practical love
Killed by those he chose to serve
Who shattered earthen vessel's dust
Revealing treasure without rust.
Afghanistan! Afghanistan!
You bite the hand that feeds you!
You blame all others for what's diseased you!
Scepter, Red Star, Crescent, West –
You've squandered every earthly best!
The hands that helped your eyes to see
You pierced in blinded shooting spree!
You hack God's gifts and man's inventions!
You've despised all good intentions!
What shock awaits on day called Last
When quick and dead from now and past
Are raised to face you, eye-to-eye
That man you killed – he did not die!
And yet, "These are worth dying for"
You'd told your kids on bunker floor
You'd died for decades, ten times 'round
And that's how you a rich life found
Now it's my turn to do the choosing
To save my life (destiny losing)
Or risk the bullet, blade and bomb
I shall follow the steps of Tom
~ km
Tagged as: afghanistan, eternity, ode, resurrection, tom little


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Below a handpicked BBC audience practice for an upcoming show!
Monday, 27 April 2009
How they manipulate us.
Below a handpicked BBC audience practice for an upcoming show!
9 comments:
I'm remember a 2001 QT on 9-11. One of the panel member's was a former US ambassador to Britain who was left close to tears after vitriolic abuse was heaped on him by women in headscarves.ReplyDelete
Hardly watched the programme since. Enjoyed the Littlejohn bitch-slapping of Toynbee on YouTube though!
Thanks, Hank. I remember that disgusting episode as well. We just have to keep on at the bastards, though. In Hereford I was able to land a metaphorical blow on Hoon the hoon. Most satisfying for one of the little people.ReplyDelete
The BBC, soldiers, chanting? By the left, Quick March, Left, Left, Left, Left, Left....ReplyDelete
Demetrius said..........ReplyDelete
Ha, ha, ha, nice one!
- Anonymous27 April 2009 at 19:00
I got on QT once - I'm sure it's because I claimed I was of mixed parentage (which is perfectly true - 1 man, 1 woman)ReplyDelete
The programme is an pure example of the UK today - manipulated by the labour party who are funded by the unions.ReplyDelete
I can't understand for the life of me why people pay into unions who just throw their hard earned money at Gordon Brown and his crew. It must be 30+ years ago that I started to sign that I didn't want my money to go to the labour party but charity. Are all public servants stupid? I don't mean non-intellectuals btw, I mean just deplete in common sense.
I can't understand for the life of me why people pay into unions who just throw their hard earned money at Gordon Brown and his crew............ReplyDelete
The number of times it has been tried, to get an opt in rather than opt out, are legion. I, too, could never understand members' mentality. Especially when you see the Union Bosses troughing every bit as much as their political masters.Hateful!
- Anonymous27 April 2009 at 22:05
I'm think they're chanting "It started in America", or "Gordon will lead us to salvation"ReplyDelete
Boombastic, perhaps they are chanting "Gordon is a goner, bring back Blair!"ReplyDelete