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Background Although there are various expression systems for recombinant production of pharmaceutical proteins, many of these suffer from drawbacks such as yield, cost, complexity of purification, and possible contamination with human pathogens. low priced creation of pharmaceutical proteins. demonstrating that medical relevant protein like antibodies, human hormones and vaccines could be produced very in dJ223E5.2 the chloroplast from the cells [14-18] effectively. Recent work uncovered that other types just like the diatom can exhibit foreign protein with high performance also from nuclear promoters getting the benefit that even complex eukaryotic proteins can be synthesized, which need post-translational modifications and the assembly of multiple subunits. A fully-assembled and functional human IgG antibody against the Hepatitis B Computer virus surface protein (HBsAg) was shown to accumulate in to 9% of total soluble protein [19]. Furthermore, the introduction of the bacterial PHB-pathway led to efficient production of the bioplastic poly-3-hydroxybutyrate (PHB) demonstrating that algae might represent an production platform not only for proteins but also other bioproducts [20]. Efficient protein expression is an important issue, but before ending up with the final product time consuming and considerable processing actions such as cell harvesting, cell lysis followed by product purification are usually necessary. Hence, the ideal expression system does not only produce recombinant proteins with high efficiency but also secrets the proteins into the medium making many cost-intense purification actions dispensable. So far research on protein secretion in microalgae is very rare, but in cell wall deficient strains it was already shown that protein secretion of foreign proteins is basically possible even though efficiency seems to be rather low [21]. In diatoms like polysaccharides are known WAY-362450 to be secreted depending on culture conditions and the morphotype [22], however, little is known about protein secretion [23-25]. Here we show for the first time that a microalgal system like the diatom is able to secrete a fully assembled and functional human IgG antibody with high efficiency into the medium. Thus, this study highlights the great potential of these microalgae as novel protein factories secreting complex molecules, which remain functional within the medium for several days. Results Expression and secretion of a human IgG antibody by the diatom Light and heavy chain of the human IgG antibody CL4mAb against the Hepatitis B Computer virus surface protein were expressed in for two days either with (+DDEL) or without an ER-retention transmission (?DDEL). … In the following, a set of impartial transfectants was tested for antibody secretion to see whether secretion is usually a rare exception occurring accidentally in some cell lines or whether antibody secretion occurs routinely with differences in secretion efficiency. In a small scale screening twelve impartial cell lines were cultivated under non-induced circumstances until achieving a density around 0.2 (OD600). Subsequently, cells had been used in nitrate WAY-362450 filled with moderate WAY-362450 for just two protein and times of the cell-free moderate had been focused, utilized and precipitated for following Traditional western Blot analyses. Aside from one cell series, which didn't generate detectable antibody amounts, all the cell lines examined portrayed and secreted the antibody with differing efficiency (Amount?2). Traditional western Blot analyses with an antibody against -tubulin demonstrate which the moderate is normally free from intracellular proteins additionally, which could have already been a total consequence of broken cells. Hence, the discovered antibody in the moderate is normally solely a result of secretion. In the following, four cell lines with high secretion effectiveness (#3, #8, #11 and #12) were selected for broader analyses on features and.
We used global transcript analyses and mutant studies to investigate the
We used global transcript analyses and mutant studies to investigate the pathways that impact H2 production in the photosynthetic bacterium cultures. production rate (Fig. 3A; see also Table S2 in the supplemental material). This suggests that their abundances are impacted by some regulator in addition to NifA since NifA activates transcription in the absence of NH4+ (15) and thus should be comparably active in all glutamate-containing cultures. The transcript pattern also shows that the cellular H2 production rate is not determined solely by transcript levels since the lactate- and succinate-fed Rabbit Polyclonal to GFP tag. cultures have higher rates than the glucose-fed culture though all three contain similar transcript levels (Fig. 3A). A role for nitrogenase secondary to fixing N2 is evident from the properties of a nitrogenase deletion mutant (NifHDKr1) (see the supplemental material for mutant construction). The nitrogenase mutant grew similarly to wild-type cells when provided with NH4+ as the nitrogen source or when glutamate was the sole nitrogen resource and glycerol xylose or blood sugar was the principal organic substrate (Fig. 4). Nevertheless the nitrogenase mutant demonstrated a rise defect when given glutamate as the only real nitrogen resource and given succinate or lactate (Fig. 4) the substrates that led to the highest prices of H2 creation in wild-type cells (Desk 1; see Fig also. S1 in the supplemental materials). Therefore nitrogenase activity can be apparently necessary for ideal growth under circumstances that result in high H2 creation by wild-type cells. Fig. 4. Development of the nitrogenase Tyrphostin AG 879 deletion mutant (NifHDKr1). Data are to get a tradition given NH4+ like a nitrogen resource and succinate (+) as a natural substrate as well as for ethnicities given glutamate like a nitrogen resource and blood sugar (○) glycerol … Potential electron donors to nitrogenase. Transcripts from two operons increasing from RSP3191 to RSP3188 and from RSP3192 to RSP3199 encoding electron transportation protein (including ferredoxin I encoded by [RSP3189] [10]) and RnfABCDGEH a membrane Tyrphostin AG 879 proteins complex proposed to lessen ferredoxin I (1 23 had been more loaded in H2-creating cells than in non-H2-creating cells (Fig. 2; discover also Desk S2 in the supplemental materials). Several transcripts also display build up patterns that act like those of the transcripts (and genes and that their protein products provide electrons to nitrogenase in (23). The higher abundance of RSP1751 transcripts (putatively coding for ferredoxin V [FdV]) in H2-producing cells than in non-H2-producing cells (Fig. 2) suggests that FdV may also have a role in electron transport to nitrogenase. However the RSP1751 transcript pattern in cells with different cellular H2 production rates differs from that seen Tyrphostin AG 879 for the and RSP3188-3199 genes (Fig. 3A) suggesting that RSP1751 is not transcriptionally coregulated with these other genes. Indeed the RSP1751 promoter does not appear to contain sequences related to known regulators of transcription (not shown) so it is unclear how its transcript level is increased in H2-producing cells. Hydrogenase transcript abundance and H2 production. Transcripts encoding the uptake hydrogenase (HupSL) enzyme and its accessory proteins are present at higher levels in H2-producing cells than in non-H2-producing cells (Fig. 2; see also Table S2 in the supplemental material) likely reflecting H2-dependent activation by HupR (27). However we unexpectedly found negative correlations between uptake hydrogenase-related transcript abundances and cellular H2 production rate (transcripts including those Tyrphostin AG 879 encoding isoforms of ribulose 1 5 carboxylase/oxygenase (RubisCO) the enzyme that assimilates CO2 are less abundant in H2-producing cells than in non-H2-producing cells (Fig. 2; see also Table S2 in the supplemental material). In addition many transcript levels are also negatively correlated with the cellular H2 production rate (transcripts that code for the two isoforms each of fructose-1 6 and phosphoribulokinase are significantly higher in abundance in H2-producing cells than in non-H2-producing cells (see Table S2 in the supplemental material). CfxA?B? a mutant unable to fix CO2 via the CBB pathway cannot grow photoheterotrophically in media containing NH4+ (6). This defect was proposed to reflect a requirement for photoheterotrophic cells to recycle excess reductant through the CBB pathway (6). Though our data suggest that diverts electrons toward nitrogenase.
Fragile X-associated tremor/ataxia symptoms (FXTAS) is certainly a neurodegenerative disorder connected
Fragile X-associated tremor/ataxia symptoms (FXTAS) is certainly a neurodegenerative disorder connected with delicate X premutation companies. that among the Flavopiridol rCGG-repeat-binding proteins hnRNP A2/B1 is certainly involved in this technique via relationship with heterochromatin proteins 1. Knockdown of RNA by RNAi could suppress the neuronal toxicity due to rCGG repeats. These data indicate a surprisingly energetic function for retrotransposition in neurodegeneration together. INTRODUCTION Neurodegenerative diseases are a heterogeneous group of disorders characterized by the progressive loss of structure and/or function of neurons (1). Many neurodegenerative disorders are caused by genetic mutations within the coding regions such as CAG repeat expansions that can directly alter the function of specific proteins; however recent studies also suggest that toxic RNAs can directly cause several neurodegenerative disorders among them delicate X-associated tremor/ataxia symptoms (FXTAS) which is certainly associated with delicate X premutation providers (2). Delicate X symptoms (FXS) is normally caused Rabbit Polyclonal to MLH3. by enlargement from the CGG trinucleotide do it again in the 5′ untranslated area from the delicate X mental retardation 1 (gene are recognized to donate to the delicate X phenotype through hereditary instability plus Flavopiridol they can broaden into the complete mutation during germline transmitting (5). In the last 10 years FXTAS a late-onset neurodegenerative disorder continues to be known among many man premutation providers in or beyond their 5th 10 years of lifestyle (6) and FXTAS is certainly distinct in the neurodevelopmental disorder FXS. The most frequent scientific feature of FXTAS is certainly a progressive actions tremor with ataxia. Almost all autopsy Flavopiridol research in the brains of symptomatic premutation providers present degeneration in the cerebellum which include Purkinje neuronal cell reduction Bergman gliosis spongiosis from the deep cerebellar white matter and enlarged axons (7 8 The main neuropathological hallmark and postmortem criterion for definitive FXTAS is certainly eosinophilic ubiquitin-positive intranuclear inclusions broadly distributed through the entire human brain in neurons astrocytes and in the spine (7). One exclusive molecular signature from the delicate X premutation allele is certainly that the amount of FMR1 mRNA is certainly significantly elevated as the FMR1 proteins (FMRP) remains fairly unchanged in cells from premutation providers (9 10 therefore the neurodegenerative phenotypes connected with FXTAS are suspected to be the effect of a gain of function in delicate X premutation rCGG-repeat RNAs (5 11 It's been hypothesized that overproduced rCGG repeats in FXTAS sequester particular RNA-binding protein and decrease their capability to perform their regular cellular functions thus contributing significantly towards the pathology of the disorder. The current presence of mRNA in inclusions within Flavopiridol the brains of FXTAS sufferers aswell as the forming of equivalent inclusions upon ectopic appearance of rCGG repeats in model systems possess provided solid support because of this hypothesis (11-14). Two RNA-binding protein Pur α and heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 could bind rCGG repeats particularly in both mammalian and brains (15 16 Both Pur α and hnRNP A2/B1 are located to be there in the inclusions of FXTAS human brain tissues and may modulate rCGG-mediated neuronal toxicity. Cell hereditary elements or their remnants populate the genomes of nearly every living organism (17). Transposable Flavopiridol elements (TEs) include users of both DNA and RNA families of transposons (retrotransposons). Retrotransposons can be further subdivided into long-terminal repeat (LTR) non-LTR (nLTR) groups inverted repeat (IR) elements and repeat-containing elements. So far there is no evidence that this DNA elements are currently active whereas retrotransposons are considered active (18). The potential negative effects of mobile elements around the fitness of their hosts have led to the development of strategies for transposon control in different organisms. Active retrotranspositions are reported to cause human diseases including several types of malignancy through insertional mutagenesis of genes critical for preventing or driving malignant transformation and active retrotranspositions contribute to inter-individual genetic variance (17 18 New retrotransposition is found to generate genomic plasticity in neurons by causing.
This study was performed to determine the association of Th17 cell
This study was performed to determine the association of Th17 cell phenotype with chronic allograft dysfunction in kidney transplant recipients (KTRs). cells. The CAD group showed increased percentage of Th17 cells out of CD4+ T cells and also increased proportion of IL-17 producing cells out of effector memory T cells or out of CCR4+CCR6+/CD4+ T cells compared to the LTS group and other control groups. Also the serum level of IL-17 IL-33 and RAGE and the expression of IL-1beta RAGE and HMGB1 mRNA showed an increase in the CAD group compared to the LTS group. In vitro study revealed that IL-17 increased production of IL-6 and IL-8 and up-regulated profibrotic gene expression such as for example ACTA-2 and CTGF in HPRTEpiC within a dose-dependent way which implies that IL-17 includes a function in the introduction of renal Rabbit Polyclonal to SHP-1 (phospho-Tyr564). tubular cell damage. The outcomes of our research may claim that boost of Th17 cell phenotype is actually a marker for the persistent allograft damage; hence there's a PXD101 have to develop healing and diagnostic equipment targeting the Th17 cells pathway. Launch After kidney transplantation Compact disc4+ T cell mediated allo-immune replies play an essential function in the introduction of chronic allograft rejection and dysfunction. Certainly there is constant evidence to aid the participation of particular populations of Compact disc4+ T cells in the approval or rejection from the allograft with the PXD101 host disease fighting capability [1 2 3 4 5 6 As a result PXD101 understanding the activation or suppression of a particular Compact disc4+ T cell subset in kidney transplant recipients (KTRs) regarding to their scientific status will be beneficial to unveil the average person contributors towards the development of chronic allograft dysfunction. In the meantime Th17 may be the most recently uncovered Compact disc4+ T cell subset which is seen as a the production from the pro-inflammatory cytokine IL-17 [7 8 Accumulating evidences demonstrated that Th17 cells get excited about driving immune procedures previously regarded as solely Th1 mediated in a variety of autoimmune illnesses [9 10 11 12 Furthermore ongoing recent research recommended that activation of Th17 cells may are likely involved in the introduction of allograft damage in PXD101 body organ transplantation [13 14 15 16 17 Our prior studies also demonstrated the scientific significance of elevated Th17 infiltration in turned down allograft tissues or increased percentage of Th17 cells in the peripheral bloodstream of KTRs [18 19 20 In this respect the purpose of this research is to research the significance from the Th17 cell pathway in the development of chronic allograft dysfunction in KTRs. As a result within this research we evaluated the T cell immune profile including Th17 cells in patients with chronic allograft dysfunction compared to long-term allograft survivors with favorable allograft function and control groups such as stable KTRs with a short-term follow-up period end stage renal disease (ESRD) and healthy controls (HC). Materials and Methods Patients and clinical information Before defining each group we investigated the yearly change in the average value of estimated glomerular filtration rate (eGFR) calculated by Adjustment of Diet plan in Renal Disease (MDRD) formula in 587 sufferers who underwent kidney transplantation between 1995 and 2010 and the existing laboratory data is certainly offered by our middle (Fig 1A). Predicated on the outcomes the definition from the long-term steady group (LTS group) was sufferers who had been at least a decade post-transplantation and demonstrated higher MDRD eGFR compared to the suggest worth at each concordant post-transplant season. The definition from the persistent allograft dysfunction (CAD) group was KTRs who had been at least 24 months post-transplantation and demonstrated MDRD eGFR significantly less than 40 mL/min/1.73m2 and histological proof IF/TA (TA [ct≥1] and IF [ci≥1] involving a lot more than 25% from the cortical region) [21]. Another three control groupings had been included; KTRs using a follow-up length of significantly less than six months after KT and demonstrated steady scientific course were contained in the early steady (Ha sido) control group; End-stage renal disease (ESRD) sufferers who had been on hemodialysis or peritoneal dialysis for at least three months were contained in the ESRD group and healthful volunteers who demonstrated regular renal function without root renal disease had been contained in PXD101 the healthful control (HC) group. Desk 1 displays the baseline scientific features of included individual inhabitants and Fig PXD101 1B displays the distribution of MDRD eGFR in each group. This research was accepted by the Institutional Review Panel (KC10SISI0235) from the Seoul St. Mary's Medical center and written up to date consent was extracted from all sufferers. Fig 1 Distribution of allograft function in.
Adaptive immune responses are initiated when T cells encounter antigen in
Adaptive immune responses are initiated when T cells encounter antigen in dendritic cells (DC) in T areas of supplementary lymphoid Tolfenamic acid organs. during viral infection in both LN DC and FRC. As a consequence the primary T cell response was found to be exaggerated in [14] [15]. These chemokines also increase DC maturation and function (examined in [16]). Third IL-7 enhances T cell reactions to viral infections [17] [18]. Collectively these observations have strengthened the notion that TRC help in the induction of T cell reactions by accelerating T cell priming and development. However recent reports possess suggested Tolfenamic acid that TRC may also negatively regulate T cell reactions. TRC were shown to express the inhibitory programmed death ligand 1 (PD-L1) therefore reducing CD8 T cell mediated pathology [19]. TRC also express Tolfenamic acid self-antigens in the context of MHC class I thereby advertising CD8+ T cell tolerance [20] [21] (examined in [22] [23]). In addition stromal cells isolated from neonatal or adult spleen were shown to induce over 1-2 weeks the development of DC that inhibit T cell proliferation experiments and the lack of appropriate tools to investigate TRC and approaches to study the effect of TRC on CD8+ T cell priming by antigen-pulsed DC. We demonstrate that TRC diminish T cell development by liberating NO. They share this house having a subset of DC. We display that NO production by TRC and DC is definitely strongly dependent on cytokines from triggered T cells suggesting a negative opinions loop once T cell priming provides started. Our results using isolated TRC (Fig. S1 and data not really shown). As opposed to TRC [9] cell lines portrayed only low degrees of and transcripts. To circumvent this caveat preliminary tests included exogenously added CCL19 CCL21 and IL-7 protein without difference in the results (data not proven). To review T cell priming Compact disc45.1+ congenic ovalbumin (OVA)-particular OT-I T cell receptor (TCR) transgenic Compact disc8+ T cells had been labeled using the proliferation dye carboxyfluorescein succinimidyl ester (CFSE) blended with unspecific WT T cells (Compact disc45.2+) within a proportion of 1∶50 and cultured as well as antigen-pulsed BM-DC together with an adherent level from the TRC series. TRC were irradiated to limit their proliferation and nutrient intake previously. Surprisingly the full total OT-I cellular number was highly decreased in existence from the TRC series pLN2 (Fig. 1A). Using CFSE dilution to measure T cell proliferation both percentage and variety of dividing OT-I T cells had been highly reduced in the current presence of pLN2 (Fig. 1B). The upsurge in cell size Rela (FSC) and Compact disc44 appearance (Fig. 1C) aswell as the increased loss of Compact disc62L Tolfenamic acid appearance (Fig. 1D) occurred in existence of TRC but to a lower life expectancy extent. The co-cultures were supplemented with IL-2 and IL-7 so too little known pro-survival factors for na? turned on and ve T cells is normally improbable to become the trigger. Consistent with that the real variety of na?ve undivided OT-I T cells had not been suffering from the TRC existence nor was the up-regulation from the high-affinity receptor string for IL-2 Compact disc25 about dividing T cells (Fig. 1E). Importantly several other fibroblast lines founded individually from LN and spleen [26] not only shared the same surface phenotype (Fig. S1) but also the inhibitory effect on T cell development with a reduction in proliferating OT-I T cell numbers of 60-90% (Fig. 1F). Importantly main TRC isolated from na?ve pLN limited T cell development at least as strongly as TRC lines (Fig. 1G). Actually TRC isolated from pLN of mice immunized 3 days earlier with NP-CGG in Montanide adjuvant managed these inhibitory properties (Fig. 1G). Next we examined the effect of TRC about CD8+ T cell differentiation. OT-I T cells primed in presence of TRC indicated intracellular interferon gamma (IFNγ) protein (Fig. 2A) and killed target cells (Fig. 2B) although with markedly reduced effectiveness (Fig. 2B). Collectively these results demonstrate that the presence of TRC during T cell activation diminishes the development or survival of CD8+ T cells and to a lesser degree their differentiation into effector cells. Number 1 TRC dampen the development of antigen-specific CD8+ T cells. Number 2 CD8+ T cells primed in presence of TRC still create IFNγ and destroy target cells. Fibroblasts from non-lymphoid organs also attenuate T cell proliferation It has been reported that murine and human fibroblasts Tolfenamic acid can have anti-proliferative effects on activated T cells similar to mesenchymal stem cells (MSC) and certain tumor lines [27] [28] [29] [30] [31]. Therefore we tested in our system the inhibitory potential of several fibroblastic cell lines established from different.
Insulin secreted from pancreatic β-cells and glucagon secreted from pancreatic α-cells
Insulin secreted from pancreatic β-cells and glucagon secreted from pancreatic α-cells are the two main hormones employed in the pancreas within an opposing way to regulate and keep a normal blood sugar homeostasis. glucagon secretion and transcription in α-cells. Overexpressed miR-483 secured against proinflammatory cytokine-induced apoptosis in β-cells Moreover. This correlates with an increased appearance degree of miR-483 as well as the extended β-cell mass seen in the islets of prediabetic db/db mice. Jointly our data claim that miR-483 provides opposite results in α- and β-cells by concentrating on SOCS3 as well as the imbalance of miR-483 and its own goals may play an essential function in diabetes pathogenesis. usage of water and regular chow. Pancreatic islets had been isolated and purified by intra-ductal perfusion of collagenase V (0.5 mg/ml) (Sigma) following process described (33). The purified islets had been cultured in RPMI 1640 moderate supplemented with 10% FBS and 1% penicillin-streptomycin for 24-72 h based on the tests. All tests had been carried out relative to the acceptance by the pet Care Committee on the Michigan Technological School. We performed FACS to get the purified α- and β-cells from Ins1-mRFP (34) and glucagon-Cre/Rosa26R-YFP (35) mice respectively. In planning for sorting isolated islets Buflomedil HCl were dissociated and hand-picked in 37 °C with the addition of 0.05% trypsin-EDTA as defined previously (36). Digestive function was inactivated with the addition of FCS and dissociated cells had been centrifuged and resuspended in PBS formulated with 10% FBS for sorting. Stream cytometric sorting was performed on the FACSAria (BD Biosciences) using 561 and 488 excitation lines for RFP and YFP respectively. Sorted α- and β-cells had been then gathered in lysis buffer for following RNA extraction. Typically the sorted populations had been >98% real with the final yield ranging between 60 and 80%. MicroRNA Array and Data Analysis Total RNA was isolated from both βTC3 and αTC1-6 cells using TRIzol (Invitrogen) and the harvested small RNAs were radiolabeled and hybridized to the mouse miRNA array platform developed in our laboratory as explained previously (37). The obtained data were clustered using Cluster 3.0 (38) and visualized using Java TreeView (39). Quantitative Real-time PCR for miRNA and Klf4 mRNA Total RNA from islets or cell lines was extracted using the miRNeasy kit (Qiagen) according to the manufacturer's instructions and treated with rDNase I (Sigma). The TaqMan miRNA quantitative real-time PCR recognition program (Applied Biosystems) was employed for quantification of miR-483 and its own appearance was normalized Buflomedil HCl towards the comparative appearance of RNU19. For mRNA quantification cDNAs had been produced using the Great Capacity cDNA change transcription package (Applied Biosystems) and quantitative real-time PCR was performed using the energy SYBR Green PCR get good at combine (Applied Biosystems). Real-time PCR was performed on the StepOnePlusTM program (Applied Biosystems) using the next Buflomedil HCl method: 10 min at 95 °C 40 cycles of 95 °C for 15 s and 60 °C for 1 min. All examples had been operate in duplicate as well as the RNA appearance was motivated using comparative comparison technique (ΔΔCt) with hypoxanthine guanine phosphoribosyl transferase (Hprt) mRNA as an Buflomedil HCl interior standard. Listed below are the primers found in the analysis: pre-insulin GGGGAGCGTGGCTTCTTCTA (forwards) and GGGGACAGAATTCAGTGGCA (invert); glucagon AGAAGAAGTCGCCATTGCTG (forwards) and CCGCAGAGATGTTGTGAAGA (change); Hprt TCAGTCAACGGGGGACATAAA (forwards) and GGGGCTGTACTGCTTAACCAG (change). In Situ Hybridization and Immunohistochemistry Staining Dissected mouse pancreas had been set in 4% formaldehyde (pH 7.4) for 24 h in 4 °C and processed routinely for paraffin embedding. Tissue had been trim into 5-μm areas and honored cup slides (Superfrost Fisher Scientific). For hybridization areas had been initial deparaffinized and rehydrated and treated with proteinase K (Roche Applied Research 40 μg/ml) as defined (40). Briefly a complete of 3 pmol of DIG-labeled Locked Nucleic Acidity (LNA) probes (Exiqon) had been blended with 200 μl of hybridization buffer and used onto the slides to hybridize at 37 °C for right away. Slides had been then cleaned using 2× SSC alternative and incubated with alkaline phosphatase-conjugated sheep anti-DIG antibody (Roche Applied Research) at 4 °C right away. Alkaline phosphatase response was completed with 50 mg/ml NBT/BCIP (4-nitro-blue tetrazolium/5-brom-4-chloro-3′-indolylphosphate) staining.


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A quirk of fate puts a Blatina in the Oval Office. What now?
Toni Madison never dreamed about becoming President. It simply wasn't even an option for someone like her, a Black Latina after all.
Life had a different plan as a heart attack places her behind the Resolute Desk in the Oval Office.
Now, three years into her bland accidental Presidency, Toni notices she could do better. In fact, she wants to do better.
She wants to be a great President.
Things start to heat up as she launches her election campaign.
She quickly realizes that there are many people who are honestly threatened by a woman of color serving in the highest office of the land.
When threatened, people tend to respond with underhanded, manipulative viciousness.
How will Toni handle all that?
As betrayals follow threats that follow intense pushback, Toni reaches back to her gritty youth to find succor along with the support of her quirky, loyal staff.
Readers say…
"...we watch fascinated as Toni comes into her own. Step by painful step."
"Very entertaining & relevant in today's political landscape."
"In the crazy political climate of today, this was a delightful and yet insightful read."
The WEEKLY DEALS is a weekly digest email sent to readers signed up for the genre of your choice. This mailing uses a different sending engine than the Daily Deal itself, so some readers who miss the Daily Deal for whatever reason (spam filters, timing, vacations...) may get this mailing. (And if they get both, even better! we all know the data about how people often need to see things multiple times before they react...)
Mailing goes out EARLY on Wednesdays and covers that Wed until the next Wed. So if your deal is on a Tuesday only and you submit it the Monday before - that won't work for the weekly mailing. But if you submit on Monday for a Daily Deal on Tuesday, and your book is on sale Tues-Thurs, for example, then you're good - Daily Deal will go out on Tuesday and you'll be included in the Weekly Deals on Wed. showing the end of your sale on Thursday.
I'll create an ad for you that will run at the top of the Book Fair page - the page people are sent to after they enter the giveaway.
Not only will you get more exposure, but you can keep the ad!
Push a free, 99c or full price book - whatever you need promoting. Doesn't have to be the same book in the giveaway!

subset: commoncrawl


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1. Outline
Start with a large rounded triangle to show the position of the legs. Above it, sketch a pointed oval for the body. Draw a rounded heart-shaped head. Add a vertical oval shape for an arm.
Attach it to the body with two lines. Form a pointed oval around one end of the arm for the mitt. For the raised leg, draw a rounded V-shape and a pointed oval.
Show the other leg as an oval. Below it, draw a rounded triangle for the foot. Use two short lines for the ankle.


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Tag Archives: Rey Mysterio
WWE Fastlane Live Coverage – Becky Lynch Vs Charlotte
Check out our WWE Fastlane live coverage featuring Becky Lynch vs Charlotte.
Survivor Series Live Coverage – Daniel Bryan Vs Brock Lesnar
Check out our Survivor Series live coverage with Daniel Bryan vs Brock Lesnar and Charlotte facing Ronda Rousey.
Smackdown 1000 Live Blog
Hang out with us as we live blog Smackdown 1000.
The Fight Game Podcast – All In Recap (Ep. 35)
GG and John LaRocca are back on the Fight Game Podcast with their All In recap.
All In Live Coverage – Cody Rhodes Vs Nick Aldis


text: Oak Stained MauveFrom January 2019 new color stains are available: sage and mauve. This creates two completely new worlds for the ZEITRAUM range. A complex technology of staining wood provides a semi-transparent appearance and allows the natural texture and depth of the timber to stay visible. Mauve is the color equivalent to sage. Both harmonize with each other, but can also be individually incorporated into different style worlds. We love mauve especially in combination with our warm, dark walnut wood. The frosted blackberry radiates independence and fits particularly well in an ambience with parquet, high ceilings with stucco, antiques or midcentury style. The profound Mauve gives our furniture a skilful twist and transforms it into individualists.


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Go Topless: How to Make a Hoist for Your Jeep Top
If you have a Jeep already, you know how difficult it can be to take your Jeep top off yourself. You will probably need a helper or two to get it off, and then you have to find a place to store your top in your garage, which can take up quite a bit of space. Taking your Jeep top off is the best part of owning a jeep, so if you aren't able to take it off in the summer to feel the wind in your hair and the sun on your face, that is a shame. See below for instructions on how to make a hoist for your jeep.
Here's What You'll Need:
- 4 eyebolts
- Ratchet straps (with hooks)
- Chains (optional)
- Pull your Jeep into your garage and measure the length and width of your Jeep top. These measurements will be used for placement of your 4 eyebolts. They should line up with the front and back of your Jeep top. Screw the eyebolts into the ceiling joists so they are secure in the ceiling (simply going through the drywall will not hold the eyebolts securely enough).
- After the eyebolts are attached, you can place the hooks of the ratchet strap in the back eyebolts.
- Lift the back window hatch of your jeep and unlatch the front latches holding your top in place.
- Run the strap through the back window (between the window and the hard top) and through the front (this may require you to lift the top up a bit to get the strap through).
- Attach the front hooks to the two front eyebolts and begin ratcheting the top up to the ceiling and off of your Jeep. If the straps aren't long enough to reach those front hooks, you can use chains to help give you the length needed.
At this point, you should be able to pull your topless Jeep out of the garage and out into the open air. Keep your top hoisted up high enough that you can pull your Jeep or other vehicle into the garage without the top being in the way of anything in your garage.
This hoist provides an easy way to take your Jeep top off in those hot summer months without your needing to have another person to give you a helping hand. It also allows you to keep your hard top stored without taking up any precious space on your garage floor. This hoist will work for a two-door or a four-door jeep.
If you're concerned about how safe any action is for your Jeep, don't be afraid to consult your Jeep dealership.


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New year's resolutions for radio
Radio Tomorrow with James Cridland
Welcome to 2019. How are your personal New Year's Resolutions going? I thought I'd suggest a few for the radio industry
Lower your ad load - twelve or even fifteen minutes of ads an hour is a poor experience when compared to many of our competitors. In many cases, ads are being sold at a spot rate that hasn't changed in thirty years. Easier said than done, but this is a nettle that needs grasping at some point - before someone else does it for us.
Rethink how you make multi-platform radio - on a very basic level, if you never tell the time on a radio show, you can re-run that radio show, or that part of that radio show, later. If you focus on making great short-form content, you can use that on the air and online, in podcasts or more interactive services. A great piece of radio deserves to be used more than once. What does this mean for how you make it?
Focus on delighting your audience - commercial radio exists, yes, for ratings and revenue, but without ratings comes no revenue, and without a focus on delighting our audience, we have no ratings. Everything we do should delight audiences first and foremost; which means treating them with respect.
Focus less on tradition, and more on innovation - the past is a different country, where we did things differently. Radio's strength is that we can change the way we do things. There's no room for "doing things the way we've always done it" in the radio industry of 2019: we've never had the competition we have now.
No more antique microphones - some of the radio industry seem bizarrely happy to use pictures of old-fashioned microphones, 1940s transmitters and old Bakelite receivers. We use these icons in our trade associations, our staff newsletters, and sometimes even our logos. Our industry isn't like this any more. Please, stop with all that.
While radio's still incredibly strong as a medium, perhaps 2019 can be a year for radio reinvention, to make us even stronger. Here's hoping so.
About The Author
James Cridland, the radio futurologist, is a conference speaker, writer and consultant. He runs the media information website media.info and helps organise the yearly Next Radio conference. He also publishes podnews.net, a daily briefing on podcasting and on-demand, and writes a weekly international radio trends newsletter, at james.crid.land.


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Wednesday, 23. August 2017
Writing a Simple DSL Compiler with Delphi [0. Introduction]
The Delphi Geek – Part 0: IntroductionSome time ago I was listening to the Hanselminutes podcast where a guy described how he wrote a simple interpreter in Go language (YOU should write an interpreter with Thorsten Ball). I was not really interested in writing an interpreter - I did that a long time ago - but a ...
RAD Studio 10.2.1 HotFix for iOS AdHoc Deployment
Marco's Tech Blog – We released a hotfix to address a regression (reported as https://quality.embarcadero.com/browse/RSP-18813) in RAD Studio Tokyo Release 1 related with AdHoc deployment for iOS. The fix available for download is at: https://cc.embarcadero.com/item/30797 The fix (which is a single ...
Continuous Regression Testing
blog.gurock.com – Despite all effort to move quality upstream, most organizations I work with have a regression testing process. This process is expensive and slow, so they do it less often; 'batching' a large number of changes into a sprint, a release, or a project. With more time between releases, the uncertainty ...


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As a result of the recent two weeks long removal of sand from Tenby harbour, there is a problem.
The change in the sand bed and, specifically, the sand bar outside the harbour area has produced an unexpected tidal rip on incoming tides. And this rip has pulled out a number of the harbour's moorings.
A spokesman for Pembrokeshire County Council stated that the tractors and trailers will be back this morning to undo the damage. The spokesperson hoped that sufficient sand could be returned by the end of the week to stop further damage. The moorings will then be repaired, in time for the boats' return to the water at the beginning of May.


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Maxim is the market leader in USB automotive-grade protectors with iPod®/iPhone®/iPad® fast-charge detection and USB host-charger detection for all USB devices.
Our protectors' fast-charge detection supports both Hi-Speed USB (480Mbps) and full-speed USB (12Mbps) operation, which conveniently lets consumers recharge their USB devices while driving. These fully integrated devices combine several automotive-specific benefits, including short-to-battery and short-to-ground protections, which are required in today's harsh automotive environment.
Maxim's automotive USB protectors are perfect for:
Maxim also offers system-level modeling and simulation support to achieve the best performance for customer-specific applications.
Our automotive-grade USB products are only available to manufacturers of high-volume automotive products. If this describes your organization and you would like more information, please contact us.
View Maxim's standard USB products.


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The Happy Hearts line embraces the heart as a symbolic motif of the Happy Diamonds collection, interpreting it with playful creativity. This timeless pendant in 18-carat rose gold features a large diamond-set heart suspended from a smaller heart housing one of Chopard's celebrated moving diamonds, in a sparkling celebration of love.
|Pendant, 45cm chain length
|18-carat Rose Gold
|Diamond 0,92 carat
|The price of the jewels may vary depending on their diamonds carat weight and value.
See the entire Chopard´s collection available online at Torres Joalheiros, or, discover the world of Chopard Jewellery at www.chopard.com


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To write my essay about natural disasters, I would start by defining natural disasters. A natural disaster is the effect of any natural hazard. Some examples of natural hazards are floods, tornados, volcanic eruptions and earthquakes.
For further analysis and to give it more structure, I would write my essay and describe the different types of natural hazards. All of them are very familiar to us. We don't really have to experience going through it to know what it is.
Another thing that I can mention when I write my essay is some examples of the worst natural disasters recorded in history. One of the most recent being the 9.0 magnitude earthquake that rocked Eastern Japan. This is one of the worst earthquakes recorded in history, killing over 15,000 people and leaving some 5,000 injured. Aside from this earthquake, I can discuss other major natural disasters around the world.
To add a more human feel when I write my essay, I will also talk about how natural disasters have affected people. I would discuss first the physical damage done to the surroundings then go into detail on the people. Natural disasters don't just do physical damage, it is also capable of doing emotional damage on its victims. There are some people who have phobias and children who are traumatized because of their experience with natural disasters.
And from there, I can add more information in between so my readers will be able to understand more about natural disasters and the effects they have on people.


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Athletes and Acne: Tips and Treatment by Nadia Amy @_nawdzz
Acne though superficial, should be taken seriously just as any other health condition, in fact, most major league sports teams have a team Dermatologist.
Acne in athletes can originate from a number of factors like the obvious sweat, player to player contact, shaving, cleanliness of clothes, testosterone and hormones alike.
(Guest post by Nadia Amy - IG @_nawdzz)


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CHINA: Glimpse PR is spearheading a full-service PR plan for US fashion chain American Rag as it prepares to enter the Chinese market.
The brand will begin trading in the country this Fall with the opening of its flagship store in Shanghai. It then plans to open a further 30-40 stores across China and Hong Kong.
Glimpse PR signed a retainer deal with the company in January and is now ramping up its work ahead of the first opening.
The contract encompasses events, media relations, copywriting, design and social-media management.
"Given that its American Rag's first entry in the Chinese market, it currently has low brand awareness but holds an aggressive expansion strategy plan for the next three to four years," said Glimpse managing director Mabel Yao.
"Therefore we are targeting nationwide B2B and B2C traditional media and well as using China's social media platforms to educate the customers about the brand's values and business model while collaborating with emerging Chinese talents and bloggers.
"We are also activating their social media platforms such as Weibo and WeChat in order to communicate with the audience about the brand's history and denim culture."
Recently Glimpse was also appointed by the luxury heritage Swiss brand Jaquet Droz (within Swatch Group) to create an integrated PR strategy across social media, events, and traditional media for Greater China, while Marchon Eyewear named it as its official PR agency in the country.
The agency has a strong portfolio of luxury brands, but Yao said it was still a good time for the higher-end of the market, despite a reduction in economic growth and government crackdowns on the gifting culture among officials.
"Although the luxury market has entered a general slowdown, I believe it is still a good time for the luxury market in China as the Chinese still have a need and requests for luxury products/services. However, brands [need to be] more inspirational, CRM-oriented and have strong and clear communication around brand values, rather than only showcasing big 'blinged' logos," she added.
The agency, which is 10 years old, is growing around 15 to 20 percent per year, she added.
Follow PRWeek Asia on Twitter, Facebook and LinkedIn for the latest news, insights and opinion.
Plus, sign up for our weekly email bulletins; The Breakfast Briefing (for PRWeek subscribers) and The Mix (for everyone!)


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- This event has passed.
Fire & Ice Family Skate Night
January 17 @ 6:00 pm - 8:00 pm
Fire & Ice!! Bring the whole family for a fun night of skating & sledding, We will have a fire pit to keep warm and make smores, Hot Cocoa and popcorn will be served as well. We will hold these family skate nights every Friday in January & February while rinks are open. Registration is not required.


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Speaker explains risks, impact of elder financial exploitation
U.S. seniors lose more than $2.9 billion every year to greedy financial predators, said Iris Freeman, co-founder and president of the Minnesota Elder Justice Center, who presented at Holy Name of Jesus in Wayzata April 21.
In most cases, these predators are not strangers with elaborate schemes; rather, they are family members, caregivers or trusted advisors, explained Freeman, who meets with community groups, geriatric professionals and public officials to explain the risks and impact of elder financial exploitation.
"We need to act and stop elder abuse because it takes away the safety and security of people's dreams," Freeman said. "I want people to be aware of the warning signs, so if someone you know is at risk, you can take steps to intervene in these very complicated, but commonplace situations."
To help attendees understand what financial exploitation looks like, Freeman showed attendees a video clip describing a case from Duluth in which an elderly woman's son used more than $100,000 of her savings to purchase a truck and other personal items instead of paying for her long-term care.
The case, in which the perpetrator was a police officer, highlights the fact that even well-respected community members and family members pose a threat to vulnerable older adults.
Defining financial exploitation
The Minnesota Elder Justice Center defines financial exploitation as "acquiring possession or control of a vulnerable adult's funds or property through pressure, deception or fraud." In the most notorious cases, perpetrators include sons, daughters, paid caregivers, religious leaders, financial advisors and "sweethearts." In other cases, strangers target older adults with a variety of scams involving health care fraud, identity theft, bogus contests and prizes, and phony charities and business opportunities.
Larry Gleason, a parishioner at Holy Name of Jesus since 1982, attended the event to learn how to protect himself and his wife from financial exploitation.
"I appreciate the importance of this issue," Gleason said. "It's a big thing to be concerned about."
He and his wife are especially concerned about being exploited via phone calls. They let all calls go to their answering machine and only pick up if they recognize the voice of the caller. Gleason said he was surprised and saddened to learn people need to be aware of the motives of their family members.
Experts predict a steady increase in elder financial exploitation cases as baby boomers move into their 70s and 80s. Freeman said adults become more vulnerable as they age due to losses of cognitive function, hearing and sight. The impact of financial loss from exploitation can be devastating for those who have a limited ability to earn money to recover lost savings. Large financial losses often lead to depression and other health issues, and financial dependence on family or public resources.
Sharing knowledge
Freeman explained that like most crimes, financial exploitation "thrives in silence." She encouraged everyone to share their new knowledge by having conversations about potential threats with their loved ones.
Betsy Atkinson, a Holy Name of Jesus parishioner, attended the presentation to understand the impact of being defrauded, and she looks forward to related conversations with her family and community. Her parents, who are in their mid-80s, have a unique approach to their finances that will hopefully minimize their risk of financial exploitation.
"I give great credit to my parents who hold an annual meeting with all seven kids to pass on their values and describe their estate plans," Atkinson explained. "The tradition strips away the concern people would have with not knowing, and lays it all out so everyone knows."
For more information about elder financial exploitation, visit elderjusticemn.org, or contact the Minnesota Elder Justice Center at (651) 695-7646.
Category: From Age to Age


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Baltic Amber Jewelry Repair
This listing is for repairs for Baltic Amber Jewelry. We are able to repair all types of Baltic Amber Jewelry, no matter if the piece was made by us or not.
Prior to purchase: Please "Message Us" (bottom left-hand corner) with pictures of the piece so we can confirm supplies.
After purchase: You will receive an email from us with information on how to send in (or drop off if local) at your cost. This listing will also charge you $4.00 shipping. This will cover the costs for us shipping your piece back to you. If you wish to pick up your amber (local only) please add our LOCAL PICKUP listing to your cart to remove shipping fees. Please DO NOT use this code unless you have every intention of picking up your repair. If you do not pick up your repair within 7 days, we will discard your jewelry.
Repairs include evaluation and taking apart the jewelry piece, washing and sunning all Baltic Amber beads, restringing of all beads and new clasps (if needed). We will also replace any cracked or damaged beads at no extra cost. Orders using a coupon code will be canceled immediately.
Repairs will come with a 30-day limited warranty and will only cover repairs needed from faulty craftsmanship. Please note, although our necklaces are strung on a strong, silk thread, repeated pulling on the necklace, by your child or someone else, will cause the thread to be pulled apart from the clasp. It is evident this has occurred because the spacing between the last knot and the end of the clasp becomes longer over time. As such, we advise you to ensure your child is NOT pulling on or playing with the necklace whether it is being worn or not. Once the thread has been pulled completely from the clasp, the entire necklace will have to be restrung in order for the necklace to be worn again safely. We do not recommend allowing your child to wear a broken necklace as this can lead to strangulation hazards. We are unable to honor any craftsmanship warranties to new or repaired necklaces due to misuse.


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Youth Ministries
April 20, 2018
Our Emmanuel youth spys escaped tonight with 9 minutes to
spare. Then we enjoyed eating at Denny's where we picked up the check for a
young couple that was seated in our immediate area. I hope the couple was
blessed by the constant chatter and excitement of us and surprised their dinner was our treat. Emmanuel youth group you are great.
From Kim DeHaven, Youth Leader


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Perseverance and Job Success
Last week was a great one for presentations, including a terrific stint with fellow Alumni at Cabrini College. The topic was Perseverance and Jobs: Job Success in Any Economy. I was kindly invited by Rachel McCarter, Director of Alumni Relations, to meet and greet with fellow Cabrini graduates from all walks. The occasion was the first in a Cavaliers in Transition ("C.I.T.") series, a networking and career building program for Alumni who are in all stages of their career.
Joining the esteemed group were Cabrini's best-of-best Career-guiders, Nancy Hutchison, Director, Cooperative Education and Career Services, and, Samantha Gil, Assistant Director, Cooperative Education & Career Services– whew! That's a lot of alumni and career expertise in one small room!
For my part, I offered this-here presentation, which I promised to share with all in attendance who helped make the night a-tiny-bit-of-a career success for all of us. You can download it from SlideShare and pass it on! There were no "program evaluations" in the traditional sense, but I welcome comments below about your experience. Please keep the alumni-network-connections going and stay in touch. And thanks for the opportunity to Be Inspired by my fellows at Cabrini College!


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The Continuing Education Center at FVCC Kid's College classes are offered during two weeks in June, July, and August. Our Black Rocket digital art camps are back, designed to bring students' ideas to life in a fun, hands-on, learning environment. The teaching staff provides extraordinary learning opportunities that stimulate creative minds, build healthy bodies and challenge adventurous souls.
Summer 2019 Schedule – online registration begins on April 10
Kids College and Black Rocket courses are all one week long, Monday-Friday, and either a morning or an afternoon session. Kids are able to attend all sessions. There is no supervision from noon to 1:00 p.m. and will need to be provided by the parent(s) should you wish them to stay on campus.
Morning: 9:00 a.m. – 12:00 p.m.
Afternoon: 1:00 p.m. – 4:00 p.m.
June 17-21 – Kids College
June 24-28 – Kids College
More Black Rocket Sessions:
July 8-12 – App.IO: Make Your First Multiplayer App! (Ages 8-10, 11-14)
July 8-12 – ROBLOX® Coders & Entrepreneurs! (Ages 8-10, 11-14)
July 15-19 – New! Battle Royale – Make Your First Fortnite® Style Video Game (Ages 8-10, 11-14)
July 15-19 – Minecraft© Modders – (Ages 8-10, 11-14)
August 5-9 – NEW! Roblox® Makers – (Ages 8-10, 11-14)
August 12-16 – Make Your First Video Game – (Ages 8-10, 11-14)
You must fill out one liability release form for each child enrolled in Kids College or Black Rocket courses. Please complete the release form at the time of registration in order to secure your child's seat in the course. After June 1, 2019 students without the liability form are subject to losing their seat to wait-listed students.
Parents: When registering your child, please click "enroll someone else"
Other Registration Options:
- Complete the Kids College registration form.
- Submit the form to the Continuing Education office:
- Fax the form to (406) 756-3351;
- Scan and email the form without card information to firstname.lastname@example.com, then call our office at (406) 756-3832 with payment information;
- In person by visiting the Continuing Education office between 8 a.m. – 5 p.m., Monday through Friday.
The office is located in the Arts and Technology Building on the FVCC Campus at 777 Grandview Drive;
- Mail the registration form with payment to: FVCC, Continuing Education, 777 Grandview Drive, Kalispell, MT 59901
Important Reminders:
- Parents or a designated adult must sign child in/out each class day.
- Please arrive no earlier than 5minutes prior to the start of class.
- Plan to pick up your child/children immediately at the end of class. If you will be delayed, notify the Continuing Education Center at 756.3832. Your child will be brought to the office for you to pick up.
- Kids College is not an all-day camp. Your child/children are NOT supervised on campus during the lunch hour.
- Students are expected to behave in a non-disruptive manner during and after class and may be dismissed from a class for behavior violations.
- Only registered students are allowed in class.
- Students are responsible for their own belongings. If items are left behind, they will be taken to the Continuing Education office.
- Students may bring water and a snack, and should wear appropriate clothing including shoes or sandals. No flip flops for tennis classes.
- Cell phones must be turned off during class.
If you like teaching and have course ideas, or have questions about Kids College, contact the Continuing Education Office at (406) 756-3832 or at email@example.com.


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Dry Cleaning Pickup and Delivery Service
Keeping your Employees Happy and Looking Good with Convenient, Dependable, Affordable, fast and flexible Dry Cleaning and Laundry Services.
Regardless of our profession, employer or position, we all like to look good - both at work and outside of work. Clean and pressed clothes are a part of that equation, but most of us cringe at the though of making that extra stop at the Dry Cleaner on the way home from work.
Image Dry Cleaners at work solves that problem for businesses and employees. We pick up, clean and deliver your garments to your home or office, or even your place of business. It's the simplest and most effective benefit we will ever offer.
Image Dry Cleaners at Work Program is simple:
- 1. We schedule the first pick-up for your business.
- 2. We will leave you some bags to offer your employees, and will provide some ideas on communicating the new employee benefit.
- 3. We come back to pick up the bags, clean everything at our own plan, then deliver everything back within a day or two to the designated spot within your office.
*Employees will be paying for their own dry cleaning and laundry. We will bill the employee's credit card for each cleaning.
See Our Quoted Pricing


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vest is designed so that the weight actually lies upon the front and back
shoulder girdle area to apply pressure directly into the muscles and sensory
receptors. This stylish denim vest does not look "therapeutic." It
is machine washable with removable vinyl covered weights that can be wiped
down to clean/sanitize. Small. Size 7-12. Chest 36"


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Your degree programme comprises a number of courses, which are usually worth a half or a full unit. You will need to select all of your courses (whether compulsory or optional) using LSE for You.
If you follow a taught programme you are required to take a certain number of courses each year as prescribed by your programme regulations. For undergraduate and most taught postgraduate students, this is normally the equivalent of four full units per year, however you can check your specific programme regulations using the LSE Calendar.
Programme regulations for the new academic year will be available from September of that year. Programme regulations from previous years which are relevant to continuing students are displayed to them in the LSE for You course selection system.
Normally courses will consist of a lecture and a class or seminar group, but this varies depending on the course. Some courses offer practical sessions, group work, workshops, field work, etc.
LSE has a range of tools to help you find the courses that your programme regulations allow you to take.
Visit finding courses for more information about these tools.
Remember that, depending on your programme, it may advisable to have a few "back-up" courses in mind in case any of your preferred courses are already full.
Visit selecting courses for comprehensive guidance about to select your courses, dependent on your level of study.
The Michaelmas Term course selection dates are:
You will be able to make changes to Lent Term half units from 10am on Monday 20 January 2020 until 5pm on Friday 31 January 2020.
1. Personal timetables will be updated within the following timeframes:
2. You will automatically be given access to the relevant Moodle pages for your courses a few hours after making your selection on LSE for You.
If you have any questions about the content of the course(s) you are considering, please contact the teaching department(s).
If you have any questions about the course selection process, please contact the Student Services Centre.
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Andrea "Cuppy" White brings her family's best recipes and southern hospitality to the locals of Ypsilanti with her soulful food.
Seen an error? Report This Listing
New Episodes Mondays 9|8c
Dive into refreshing drinks like mojitos, margaritas and more.
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Spring Weeknight Dinners


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Swiss Textiles offers its members a range of attractive sector-specific services and helps them overcome everyday challenges effectively, efficiently and in a targeted manner. We regard ourselves as a service provider and mouthpiece for our members, and we pursue a policy of active and open communication. We offer our support in strategic, conceptual and operational issues. We periodically inform our members about impending and ongoing changes in legislation and jurisprudence at both the national and the international level.
Import tariffs increase production costs. It is also thanks to the efforts of Swiss Textiles that Parliament will shortly be debating the abolition of these tariffs.
We are committed to supporting our members through targeted, personal lobbying and thus to constantly improving the political framework conditions, particularly in the areas of trade policy, employment and social policy, environment, energy and education. We stand by the fundamental principles of a liberal state structure and economic system: market economy, competition, free trade, social partnership and sustainability.
The event topics are right up-to-date and practice-oriented. We have especially benefited from the workshops focusing on blockchains and lot size 1.
We regard ourselves as a service provider and mouthpiece for our members, and we pursue a policy of active and open communication. We offer our support in strategic, conceptual and operational issues. We periodically inform and instruct our members personally about ongoing changes in legislation and jurisprudence.
The presentations at the summit provide thought-provoking impulses for our activities. In addition, many mutually rewarding exchanges take place between industry colleagues.
We network our members with one another and with players from other sectors. Swiss Textiles fosters the development and management of contacts with the leading industry players and the main design platforms and research institutions at home and abroad. Interdisciplinary projects, workshops and joint appearances at trade fairs strengthen the image and innovation potential of the textiles industry. In this way, political recognition of an innovative and profitable industry can be underscored and consolidated over the long term.
We have to have confidence in our young professionals
First-class training and education is an essential factor in innovation and enables the industry to remain highly competitive. We strongly support sector-specific education platforms so as to provide attractive, needs-based training and further education opportunities.
Swiss Textiles assumes responsibility for the basic training of EFZ (federal certificate of proficiency) textile technologists and EBA (federal vocational certificate) textile practitioners, as well as for various other vocational and higher professional examinations. We work closely together with the relevant educational institutions in order to provide targeted, market-oriented training and further education for specialists.


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Jason Burack of Wall St for Main St interviewed returning guest, entrepreneur, investor, journalist, monetary scientist, author & early Bitcoin investor, Trace Mayer https://www.tracemayer.net/.
Trace also hosts the Bitcoin Knowledge Podcast http://www.bitcoin.kn/ and he was one of the first Libertarians in the gold community to find Bitcoin and recommend people start purchasing some around 25 cents a coin!
New article about Trace Mayer saying Bitcoin is not in a bubble until Bitcoin gets to around $27,000 per coin! https://cointelegraph.com/news/ultra-rich-investor-trace-mayer-predicts-bitcoin-price-will-reach-27395-in-just-four-months
IMF head Christine Lagarde gives recent speech that touches on Bitcoin and crypto currency: https://www.coindesk.com/imf-head-christine-lagarde-it-may-not-be-wise-to-dismiss-virtual-currencies/
During this 40+ minute interview, Jason start off by asking Trace about the global economy that central banks are creating. They discuss central bank intervention and how there's a "fiat bubble."
For the rest of the interview, Jason asks Trace a wide array of Bitcoin, block chain technology, alt coin, ICO and gold related questions.
Please visit the Wall St for Main St website here: http://www.wallstformainst.com/
Follow Jason Burack on Twitter @JasonEBurack
Follow Wall St for Main St on Twitter @WallStforMainSt
Commit to tipping us monthly for our hard work creating high level, thought proving content about investing and the economy https://www.patreon.com/wallstformainst
Also, please take 5 minutes to leave us a good iTunes review here! We have 33 5 star iTunes reviews and we need to get to our goal of 100 5 star iTunes reviews asap! https://itunes.apple.com/us/podcast/wall-street-for-main-street/id506204437
If you feel like donating fiat via Paypal, Bitcoin, Gold Money, or mailing us some physical gold or silver, Wall St for Main St accepts one time donations on our main website.
Wall St for Main St is also available for personalized investor education and consulting! Please email us to learn more about it! If you want to reach us, please email us at: [email protected]


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Winter will be here before you know it, and with the change in season comes the dreaded… wait for it… cold and flu season. Did you know that up to 20% of Americans will come down with the flu every year? While it's easy to get caught up in the hustle and bustle of life, don't take any chances.
Protect yourself from these viruses by boosting that immune system. You know, the network of millions of tiny cells and organisms that help to protect your body! Here is how you can defend yourself and say, "not this year!" to the cold and flu.
Sugar from soft drinks, desserts, and candies can reduce the body's white blood cells' ability to destroy bacteria. Sugar impacts your white blood cells by competing for space in your body. When sugar takes over, it can cause major inflammation also. Let us tell you, the influenza virus looooves to make itself at home in inflammation.
In place of beverages loaded with sugar, hydrate your body with warming tea, natural fruit juice, and water. And for those tempting desserts like donuts, lava cake, and pie? Pass on those goodies and your body will thank you!
Nourish your body with the good stuff! We are talking about super foods like leafy greens, avocado, garlic, and oats aka "the building blocks of a strong immune system". While you are at it, sprinkle in some vitamin A, B6, D, and vitamin C. Get your plates ready for a diverse diet!
Vitamin A: A deficiency in vitamin a means an increase risk of infectious diseases. Be sure you are consuming an abundance of:
- Beef
- Eggs
- Dairy
- Orange/Yellow Veggies
- Mango
- Peach
- Cantaloupe
Vitamin B6: Studies have shown that a dip in B6 can cause a dip in immune response. Load up on:
- Turkey
- Tuna
- Shrimp
- Brown Rice
- Spinach
- Beans
Vitamin D: Fight the flu with vitamin D!
- Dairy
- Fatty Fish
- Eggs
- Soak up some sunrays outside (Don't forget the SPF!)
Vitamin C: This vitamin is the most celebrated for its immunity enhancing properties. It's also found in almost every fruit and vegetable (how convenient!). That means stocking up on:
- Green Peppers
- Watermelon
- Strawberries
- Kiwi
- Oranges
- Broccoli
- Tomatoes
- Cauliflower
Sleep deprivation has a negative impact on immune health. It's critical that you get at least 7- 9 hours of sleep per night to maintain over all good health –but especially in cold and flu season. Anything less than 6 hours can deteriorate the immune system making the body more susceptible to illness.
No sleep can also trigger the stress hormone making you more irritable. And nobody likes a crabby you! If you are in a sleep crunch, try taking a 20-30 power nap during the day to recharge your batteries.
Having trouble drifting into dreamland? Deep breathing and meditation before bedtime aids in reducing daily stresses and worries. You will be counting sheep in no time AND keeping the sickness away too!
In addition, make sure that you are frequently washing your hands with warm water and an antibiotic soap. Also be sure to stay clear of people who are sick and under the weather-that is VERY important.
How do you keep healthy this season? Share with us in the comments below!


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Southern Utah Adventures
Personally, it's my favorite season, because with the dropping temperatures comes the ability to start visiting one of the coolest landscapes you will ever witness; Southern Utah! With five National Parks and 16 State Parks all within an afternoon's drive from Salt Lake City, it's no wonder these parks attract millions of visitors each year from all over the world. The unique geology, red rock formations and dozens of slot canyons are unlike anything you have ever seen and encompass over a lifetime of adventures. Below are my favorite hikes within three of the National Parks; Arches, Canyonlands and Zion.
Located 5 miles north of Moab, Arches National Park contains the world's largest concentration of natural sandstone arches. Not only are there over 2,000 arches within the park, but this amazing landscape also includes enormous sandstone fins, massive balanced rocks and towering pinnacles that dwarf visitors as they explore the park's viewpoints and hiking trails.
Favorite Hike: Devil's Garden Primitive Loop. 7.2 miles and about 4 hours roundtrip. http://www.arches.national-park.com/hike.htm
An hour or so from Moab, depending on where in the park you're visiting is Canyonlands, Utah's largest National Park. With three different districts; Island in the Sky, The Needles and The Maze, Canyonlands has something for everyone.
Favorite Hike: Chesler Park Loop/Joint Trail. 11 miles and about 4.5 hours roundtrip. http://www.nps.gov/cany/planyourvisit/needleslonghikes.htm
Only 2.5 hours from Las Vegas, Zion is probably the most aesthetic National Park in Utah. With massive sandstone cliffs, endless slot canyons, and incredible wildlife you'll keep coming back never having to do the same thing twice.
Favorite Hike:
The Subway. 4 miles and about a half day hike. http://www.nps.gov/zion/planyourvisit/thesubway.htm
Did I mention Southern Utah has some of the brightest stars in the world:)!


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26 Best Alternatives to Moovly
HandBrake allows users to easily convert video files into a wide variety of different formats.
Prezi is business and educational presentation software designed to facilitate ease of movement and a more conversational method of presenting information.
Promo.com gives you ready-made video templates, high-quality footage, fully-licensed music, a built-in editor and free image tools so you can create stunning marketing visuals to promote anything, anywhere.
Celtx is a scriptwriting software platform with applications in a wide range of mediums but that specializes in helping screenwriters.
GoAnimate is a cloud-based platform for creating animated videos. It is designed specifically for use by those who do not have a background in either animation or art, and it allows users to quickly and easily build animation in a variety of styles, including 2D and whiteboard animation.
Plotagon is a piece of 3D development software that makes it easy for just about anyone to create their own artistic video using 3D animation. Plotagon is compatible with a wide range of systems, and it can produce content that can be played through just about any system as well.
LiveStream is a program where users can stream their activities, videos, or whatever they want live to anyone around the world. With LiveStream, you are able to stream your content to your audience over almost any platform and social channel using the LiveStream API and platform, and you can embed the LiveStream software onto your own website to make sure it's seen as soon as viewers reach your web page.
Emaze is an online platform from which you can control all of your social media feeds and track your social media presence. The site is compatible with most of the popular social media sites, including Facebook, Twitter, YouTube, and more.
Raw Shorts
Instantly create animations from text using our video maker. Create animations in seconds using AI technology, saving you hours on video creation.
Make and share videos using WeVideo's cloud-based online video editing software. Available on Android, iPhone, iPad, Mac, PC and Chromebook.
PowToon is a presentation application for users who want to break away from traditional marketing slides. The platform has templates that help you make entertaining and engaging animated videos and presentations.
Explee allows you to make eyecatching and interactive animated video. Go for video scribing and whiteboard animation to blow your audience away.
The best free html5 presentation maker that allows you to create awesome business presentation & animated video explainers..
VisualBee takes a plain PowerPoint presentation and automatically enhances it, creating an exciting and powerful showcase.
Animaker is an online do-it-yourself (#DIY) animation video maker that brings studio quality presentations within everyone's reach. Animated Videos, Done Right!
Wideo is a browser-based video creator that allows users to create engaging animated videos. It requires no prior experience with animation and produces amazing videos.
The vMix Software Video Mixer and Switcher is the complete live video production software solution. For more information, visit vMix online today!
Creating innovative, high-quality elearning at scale is easier with Elucidat. Unlimited authors, in-app support and dedicated customer success team to help you succeed.
Showbox is a popular app that allows users to watch content on any Android ran tablet, phone, or computer. The app is free to use and even allows you to download the content for offline viewing.
The online video platform designed for video hosting, online presentations, and multimedia live streaming. Flexible plans for business & education.
Compressor offers powerful delivery for custom output, such as 360°, HEVC, and HDR video, distributed encoding, and packaging for the iTunes Store.
Renderforest is a website where users can get free software to create professional looking slideshows, intros, animations, and music visualizations. Renderforest can be used for personal videos like family videos, wedding slideshows, or video invitations.
Automatic image enhancement and management software for Publishers. Check Claro's new features. Download a free trial at Elpical. com!
Presenter is een online communicatiebureau gespecialiseerd in krachtige content op ieder online device. Ontdek samen met ons de kracht van jouw content.
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Table of Contents
Filter Platforms
Browser (20)
Web (20)
iOS (8)
Windows (7)
Android (6)
macOS (5)
Unix (2)
Filter Features
Budget Planner
Complete Billing
Custom IPhone App
Custom Logo
Dvd Converter
Dvd Encoder
Dvd Ripper
Faster Than Powerpoint
Group Editing
Import Rich Media
Item Assembly
Item Barcode Printing
Item Barcode Scanning
Manage Inventory
Mobile Ready HTML5
Offline Presentation Mode
Presentations Library
Shared Folders
Touchscreen IPad App
Works On Windows Or Mac
Zoom And Pan On One Slide
Features of Moovly
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Moovly Reviews
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Share your opinion on Moovly
Review Summary
Moovly has currently been reviewed with 0 opinions.
In total, that's a combined rating of 0 out of 5 stars.
Additional Moovly Reviews, Pros & Cons and Similar Software
New: our editorial list of additional articles. We decided to gather informartion all around the internet and present you a list of helpful, external links to interesting reads about Moovly reviews, pros & cons and similar software.
Moovly Review - 2D Animation Software
Moovly is an animated video software that aims to make it easy for Below is a full review of Moovly, its features as well as its pros and cons. ...
0 persons liked this post.
Source: www.2danimationsoftwareguide.com
helpful or not helpful
Animation Maker: PowToon Vs Moovly Review - ANIMATION HUNTER
Moovly Review. This animation maker is a free software with a core focus on enabling everyone to create engaging multimedia content by powtoon reviewmoovly studiopowtoon animationanimakergoanimatePeople also search for ...
0 persons liked this post.
Source: animationhunter.com
helpful or not helpful
Moovly Review: Best Animation Software
Moovly is excellent animation program for 2D animation software. of Moovly, so after talking about the pros, I will make you aware of the cons. ...
0 persons liked this post.
Source: whiteboardanimationsoftwares.com
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Moovly Review - YouTube
Moovly Review. Morgan Mccall. Loading. How to create animation with the new animation software Moovly ...
0 persons liked this post.
Source: www.youtube.com
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Pros and cons of the top animated video making platforms - Sna...
Pros and cons of the top animated video making platforms . Moovly. This software allows creating materials online such as videos, animations ...
0 persons liked this post.
Source: en.snackson.com
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What is the Best Animation Software? - Business 2 Community
Let's take a look at the pros and cons of each package… . Moovly is an online animation software aimed at businesses, the education sector, ...
0 persons liked this post.
Source: www.business2community.com
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Moovly Related Youtube Video: How to create explainer videos using Moovly
Disclaimer: This video was not made by us, but we found it interesting enough to embed it here.
Comments on Moovly
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About This Article
This page about Moovly was composed by V. Tobies and published by Alternative.me. It was last updated on 2019-01-29 01:03:24 and has been viewed 18792 times.


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Our Mascots are Marlie and Wilson!
New Years Resolutions Living With Chronic Illness
Life is not easy with a chronic illness such as an autoimmune disease, Fibromyalgia or Chronic Fatigue Syndrome (CFIDS/CFS/ME). This can be a time to make some positive changes. I'm planning to, are YOU?
Click the link to hear some encouraging thoughts!
Wishing you all a happy, HEALTHY 2017!
love Patrick and Joanne
(908) 358-7167


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Every wedding is a personal occasion, the reception should be too. This is where the experience is key!
We consider ourselves to be the market leaders in our Region, constantly trying to stay ahead and offer the best possible service. From the moment you first make contact with our party advisers right up to the thank you and fair well from our DJ's at the end of the night. We aim to give you 100% customer service satisfaction.


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Welcome, Summer
It's been a long, hard year. I've learned a lot and done a lot. I'm still teaching, though I'm now on summer break. I am more than ever convinced that we need to work to make our schools better places to learn, to share, and to develop into good citizens. Unfortunately, I believe our current legal climate makes this goal an amazingly difficult one. I'm fairly frazzled, and can only hope that I will have regained my energy by the fall.


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The Independent Security Advisors Training Division eptraining.us and the World Institute for Security Enhancement (WISE) have come together to provide fully accredited Homeland Security Training and Consultation services to the private sector and Government Agencies.
To do that, the World Institute for Security Enhancement will now offer and sponsor, the ISA Dignitary & Executive Protection, and terrorism awareness and extremism training courses under a new licensing agreement. WISE instructors and all support cadre will be trained and certified by ISA master instructors and submitted for accreditation to the regulatory agencies and institutes of higher learning that have approved or accredited our EP and terrorism programs of instruction.
World Institute for Security Enhancement courses are conducted from training sites across the United States and throughout the World, which means the joint WISE & ISA mobile training teams will now have additional facilities to conduct training programs from internationally. And most WISE open session courses have been reviewed and "Approved by the North Carolina Private Protective Services Board". This Board regulates and licenses all Private Investigative, Security & Counterintelligence activity within the State of North Carolina.
In addition, to what WISE brings to the table, all ISA programs have been approved by the North Carolina Private Protective Services Board for continuing education credits, as well as received accreditations from law enforcement training commissions in six states, by universities and colleges and endorsed by the International Foundation for Protection Officers.
When you combine the 24 years of continued excellence of the World Institute for Security Enhancement, with the highly respected and fully accredited Dignitary & Executive Protection and terrorism training programs of ISA, you have an entirely whole new level and standard of training available to the private sector, law enforcement, and the government.
We hope after you do your due diligence we have an opportunity to work with you in the future.
http://worldinstitute.org/ http://eptraining.us


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Important Things to Consider When Selecting a New Hair Stylist
Your all-time favorite hair stylist has finally decided to tell you that he is moving and no not to a another hair salon but to another state. What must be the next move that you will be making? How will you ever find another hair stylist that has the same level of expertise a your favorite hair stylist who is leaving town? When you love your hair that much, you have to read till the end to get some idea about what important things to consider when selecting a new hair stylist.
Currently, your options are endless when it comes to hair stylists. Just look at hair salons and there you will see a great number of them waiting to give your hair a treatment or some styling services. So, what can you do to be sure that the hair stylist that you choose is the best one?
When the uncalled for time to choose a new hair stylist comes into the picture, you can start off by asking your hair stylist to whom they can entrust the kind of hair that you have. Try giving your current hair stylist a visit and then look around for the other hair stylists working in the salon and get his opinions if he can tell you of another hair stylist there that can give you the kind of care and treatment for your hair. When the hair stylist that you have seems to have doubts suggesting you to one of the other hair stylists working in the same hair salon as him, then it is time you look for another one outside of their hair salon.
Your next trim must be the time that you will go looking for possible new hair stylists that you can hire. When you get regular hair treatments and trims with your current hair stylist every 6 to 8 weeks, then you must immediately look for their replacement when you find out that he is leaving. You will have more time looking for your new hair stylist when you do this. Never come the point of finding a new hair stylist in a fast manner and limited time because you will just be regretting your decision if you hire the wrong person for the job.
Avoid hiring a hair stylist that you see their ads posted on your yellow pages. Their ads do not tell you a whole lot personal about them at all only that they know how to advertise. Even if you do not know a person, for instance, but you have always noticed how great their hair looks like, you can approach them and get their hair stylist suggestion. What you do next is go to the hair stylist and ask them the kind of questions that you think need their addressing if you intend to hire them.
How to Achieve Maximum Success with Options


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Basecamp: Avoiding Email Signature Images Import on Forward
Q: Whenever I forward an email into Basecamp, the system adds the .png that are in my email signature. Can this be avoided?
A: No. At this time the best thing you can do is delete your signature before you forward the email. But if anyone has any other suggestions I'm listening…
| More
We are currently offering a free copy of our 16-page eBook, "How to Organize your Digital Photography Collection" to everyone who signs up for our free newsletter. This eBook will review how to organize your digital photos, discuss metadata, and give you an overview of software than can help you with your digital photography workflow. Sign up in the signup area, located in the right-side column of every page on this site, and read your copy now!


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The Senate Agriculture Committee on Wednesday passed the massive farm bill by a 20-1 vote and overcame an attempt to tighten subsidy payments to farmers.
The draft farm bill, officially known as the Agriculture Improvement Act of 2018, contains more than 1,000 pages and covers everything from farm subsidies and food stamps to trade and rural development policy.
Farmer assistance includes commodity payment programs, as well as subsidized crop insurance.
Click here to read the complete article
Jeff Daniels ~ CNBC.com ~


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American Audio has sized up the needs of mobile DJs and tailor-made three 19-inch rack mount cases with space enough for a complete audio setup. With the introduction of the affordable new ETLC 8x4, ETLC 9x4 and ETLC 9x6 road cases, the company now offers DJs a choice between three different-sized cases to securely hold all of their rack mountable gear—from mixers and CD players to amplifiers and accessories.
A link to this page will be included with your message.
E-mail addresses supplied to this service will be used only to send the requested link.


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Thursday, November 22, 2012
Anyway we left bright and early and got there just in time for the race (literally a minute to spare - there was a 40 minute detour). The poodle is a faithful running partner. He led me to a FIVE MINUTE personal record. I am so grateful to him!!! And I've showered him with love and kisses all day! And I've had his girlfriend come over to play and let him sleep the rest of the (I'm his hero)
So seeing as its thanksgiving I'll tell you --
I am thankful for:
A poodle who is everything a doggy momma could want (and more)
A husband who gets that I have no desire to spend an eating holiday with anyone and I'd rather hang at home
Friends who love me and whom I love
The fact that I finished most of my wrapping today :-)
That lowes.com let me avoid the Black Friday shopping madness and I could order hubs' birthday gift online today and can pick it up Sunday (his b'day) at the store
The little house
<b>what are you grateful for today?
Posted by AlwaysJoy at 11/22/2012 06:47:00 PM
1 comment:
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Consumers use different types of fabrics as basic clothing and even to showcase the style and wealth. Many of the fabrics are made taking into account the weather conditions in an area. For instance, woolen fabrics are used to get warmth in winter; cotton fabrics to evade the summer heat. Using umbrellas and raincoats, on the other hand, give protection from raining downpour or scorching sun, and they are made of different fabrics too. In fact, both the terms, textile and fabric, are often used interchangeably, but actually, there are subtle differences between the two.
Textile is a term originated from 'Texere', a Latin word that means to weave. Textile traditionally refers to a woven fabric, even though people associate textiles to clothing. However, weaving comprises only one textile manufacturing technique, the other ones being knitting, knotting, and crocheting. Nowadays, textiles are also made by using a technique called felting. While natural fibers are sourced from plants to make textiles in a textile company, synthetic fibers are artificially made in labs with chemicals as well as contemporary technology. The textiles made of synthetic fibers dominate the majority of the clothing segment in the US.
Fabrics, on the other hand, are made of textile fiber with the use of techniques like weaving, knitting, and crocheting. In fact, the majority of the fabric products are either knitted or woven in a knitting mill, but there are also non-woven fabrics made of yarn using felting, twisting, and braiding. The term fabric is a generic phrase often used in reference to cloth material, which is used to make a dress or upholstery. In fact, people use 'fabric' when referring to the color, the texture, or the quality of clothes, even though the term has wider implications in actual.
Below are some of the key points that differentiate both textile and fabric in a nutshell.
- Fiber, yarn, or a combination of both can be used to make textiles. Fabric is often made from non-woven fiber or hand weaved or knitted yarn.
- Textile is a broad term used in reference to the clothing industry and engineering. Fabric forms a type of clothing.
- Textile products may be finished or unfinished. Fabric can only be finished.
- Not all of the textiles are necessarily fabric, but fabrics are indeed textile.


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CISPA Explainer #1: What Information Can Be Shared?
We've written extensively about CISPA over the last year, but since the House Permanent Select Committee on Intelligence is set to mark the bill up next week, and the full House to vote on it the week after that, we're posting in more depth about its shortcomings. Information sharing isn't offensive per se; it's really a question of what can be shared, with whom, and what corporations and government agencies can do with it. First up:
What information does CISPA allow companies to share?
The short answer: any information that "pertains" to cybersecurity, broadly defined to include vulnerabilities, threat information, efforts to degrade systems, attempts at unauthorized access, and more. You can see the full list on page 20 of the bill. You'll see that it's not tied to the criminal definition of hacking but instead forges new ground.
The bill sponsors will tell you that CISPA is only about the "ones and zeroes," but it certainly isn't drafted that way. There's nothing limiting CISPA in that manner and personally identifiable information (PII) could be shared right along with some inconsequential code that doesn't impact privacy at all. So, if your communications or records are somehow caught up in a cybersecurity data dump, they might possibly include information that identifies the real-world you, even if that information is not necessary to combat a cyber threat. Under CISPA, you'll just have to trust that the corporations holding your very personal information do what's best. Good luck with that.
The good news is that there are simple fixes that could be incorporated into CISPA which would put a layer of privacy protection over all shared data. First, the House should require that any shared information must be necessary to understand a cybersecurity threat. Under the current formulation, shared information must only pertain to such a threat. A stricter standard would help narrow the flow of information to that which is, well, necessary.
Second, the House should require companies to make reasonable efforts to remove PII from the technical data relating to cybersecurity before they share with government and corporations. This approach is endorsed in the House Republican Cybersecurity Task Force report, by a bi-partisan group of senators, and the Obama administration itself. The CISPA sponsors stated at a hearing in February that such a requirement would slow down sharing, but that's not necessarily the case.
A reasonable-efforts requirement would allow companies the flexibility to deal with the facts on the ground, and if an emergency warrants it, skip stripping out the PII if necessary. But the presumption should put the onus on the companies to take it out, and that's where it should be. All statutes have scoping language and definitions; it's just a matter of where Congress decides to draw the lines. And since Congress is so keen on granting immunity for these sharing programs, it should require the companies to make an effort to protect our sensitive data – just like dozens of other laws require now.
Next up: Who should be able to receive this cyber information? Check back tomorrow for CISPA Explainer #2 and click here to sign a petition to the president asking him to veto CISPA.
Other blogs in this series:
CISPA Explainer #2
CISPA Explainer #3
CISPA Explainer #4
Learn more about cybersecurity and other civil liberty issues: Sign up for breaking news alerts, follow us on Twitter, and like us on Facebook.
Amy C
Can you give some examples of the information that might be shared? I'm having a hard time getting my arms around why this matters to me if I'm not involved in any kind of cyber-security attacking.
- April 3, 2013
Robyn Greene, ACLU
CISPA does not set any limits on the types of information that companies can share with the government - it requires only that the information "pertains" to a cybersecurity threat. The definition of a threat is extremely broad in CISPA. This means companies can share any information they think is related to a threat, including private or personally identifiable information, such as your internet records or even the content of your e-mails. The result: everyday Americans and victims of cyber-attacks could be swept up in this information sharing program, not just cyber-attackers.
You can learn more about CISPA and other cybersecurity legislation at our cybersecurity webhub, which has ACLU and coalition letters to Congress and the administration detailing our concerns about CISPA, additional blogs, backgrounders, and a legislative comparison chart summarizing what each cybersecurity bill in consideration authorizes: www.aclu.org/cybersecurity.
- April 5, 2013
Mark C
More times than not, I find my viewpoints in direct opposition to those of the ACLU. This time though, I find myself in total agreement with you when it comes to CISPA. I applaud you for your efforts to inform and help steer the conversation on this high controversial and deceptive piece of legislation. Thank you for your hard work on this issue. We'll be contacting our elected leaders and help keep the good fight going!
- April 19, 2013


text: Metro Physical & Aquatic Therapy Share: HEALTH RELATEDPHYSICAL THERAPY Metro Physical & Aquatic Therapy Visit Website 74 Hauppauge Road Commack, NY 11725 (631) 486-6060 About Map About Long Island's oldest family owned and operated Physical Therapy practice, where we help to restore quality of life and promote overall patient wellness with the best care possible. What's Nearby? Distance: 5 10 15 20 25 50 mi.


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Our portfolio company Cloudflare announced a consumer DNS service (a resolver) yesterday.
It was not an April Fools stunt.
If you want to use the Internet's fastest, privacy-first consumer DNS service, then head over to 22.214.171.124 and click the install button.
What you will do is adjust your computer's settings to change the DNS servers your computer uses to resolve DNS queries (what server address is google.com?).
Here are some mantras from the 188.8.131.52 web page:
Unfortunately, by default, DNS is usually slow and insecure. Your ISP, and anyone else listening in on the Internet, can see every site you visit and every app you use — even if their content is encrypted. Creepily, some DNS providers sell data about your Internet activity or use it target you with ads.
We think that's gross. If you do too, now there's an alternative: 18.104.22.168
We will never log your IP address (the way other companies identify you). And we're not just saying that. We've retained KPMG to audit our systems annually to ensure that we're doing what we say.
Frankly, we don't want to know what you do on the Internet—it's none of our business—and we've taken the technical steps to ensure we can't.
We've built 188.8.131.52 to be the Internet's fastest DNS directory. Don't take our word for it. The independent DNS monitor DNSPerf ranks 126.96.36.199 the fastest DNS service in the world.
Since nearly everything you do on the Internet starts with a DNS request, choosing the fastest DNS directory across all your devices will accelerate almost everything you do online.
So if you want speed and privacy, install 22.214.171.124 and you will get both.


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The concept of the North Highland Way was born at Dunnet Head, the most northerly point of the UK mainland. The owners of the B&B, cafe and Trustees of the Dunnet Head Educational Trust (2003 to 2016) worked with the local community, and still do remotely, to develop the Way. Public services – Scottish Natural Heritage, The Highland Council, Highlands and Islands Enterprise as well as the Caithness Transport Forum and the Forestry Commission are all involved in the North Highland Way in some form. TDM Consultancy Services manage the development of the route.
The basic route is available in and Friends of the North Highland Way can see the specification in the members area on www.letsgonorth.com as well as downloadable maps and other benefits. We continue to work with walking groups and walking organisations to bring walkers to the north. We have also recently started working with cycling and horse riding groups.