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Biological Assays event taking place this May, we'll be teaming up to showcase some of the latest articles and news from our partners at BioProcess International. Today we feature a piece authored by Todd Coffey, Mike Grevenkamp, Annie Wilson, Mary Hu Biological Assay Qualification Using Design of Experiments.
In 2012, the United States Pharmacopeia (USP) published a complementary set of three guidance documents on the development, analysis, and validation of biological assays (1,2,3). USP chapter <1033> recommends a novel, systematic approach for bioassay validation using design of experiments (DoE) that incorporates robustness of critical parameters (2). Use of DoE to establish robustness has been reported (4,–5), but to our knowledge its use in qualification or validation protocols for assessing assay accuracy, precision, and linearity is not described in literature. A validation approach incorporating different levels of critical assay parameters provides a more realistic representation of how an assay will perform in routine testing.
After initial development of a cell-based bioassay to enable an investigational new drug (IND) application, we used a DoE-based approach to perform a comprehensive qualification of that bioassay to estimate its accuracy, precision, linearity, and robustness. Such an approach to qualification requires experimental and statistical effort similar to that of traditional validation for cell-based bioassays (6,7,8), but the additional insights we gained have led us to adopt this new approach as our standard method for qualifying bioassays. Here we outline our approach and describe its benefits and challenges.
Head to BioProcess International to read the methods, results and conclusions of the report.
This May at Bioassays, we'll have have experts on hand from Genentech and Eli Lilly to take a deeper look into Establishing and Qualifying Product Reference for the Relative Potency Assay. For more information on these sessions and the rest of the program, download the agenda. Would you like to join us in Berkeley? As a reader of this blog, when you register to join us and mention code B14177JT, you can save 20% off the standard rate!
1 Chapter <1032> Design and Development of Biological Assays. USP 35–NF 30, 2012.
2 Chapter <1033> Biological Assay Validation. USP 35–NF 30, 2012.
3 Chapter <1034> Analysis of Biological Assays. USP 35–NF 30, 2012.
4 Chen XC, et al. Implementation of Design of Experiments (DOE) in the Development and Validation of a Cell-Based Bioassay for the Detection of Anti-Drug Neutralizing Antibodies in Human Serum. J. Immunol. Meth. 376 (1–2) 2012: 32–45.
5 Kutle L, et al. Robustness Testing of Live Attenuated Rubella Vaccine Potency Assay Using Fractional Factorial Design of Experiments. Vaccine 28(33) 2010: 5497–5502.
6 Cheng Z-J, et al. Development of a Bioluminescent Cell-Based Bioassay to Measure Fc Receptor Functionality in Antibody-Dependent Cellular Cytotoxicity. Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research, Mar 31–Apr 4, Chicago, IL. AACR Cancer Res. 72(8) 2012: supplement abstract #2840.
7 Wei X, et al. Development and Validation of a Quantitative Cell-Based Bioassay for Comparing the Pharmacokinetic Profiles of Two Recombinant Erythropoietic Proteins in Serum. J. Pharm. Biomed. Anal. 43(2) 2007: 666–676.
8 Gazzano-Santoro H, et al. Validation of a Rat Pheochromocytoma (PC12)-Based Cell Survival Assay for Determining Biological Potency of Recombinant Human Nerve Growth Factor. J. Pharm. Biomed. Anal. 21(5) 1999: 945–959.
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Treatment of Heavy Menses
Menorrhagia is the medical term used by your Des Moines gynecologist for menstrual periods in which bleeding is abnormally heavy or prolonged. Although heavy menstrual bleeding is a common concern among premenopausal women, most women don't experience blood loss severe enough to be defined as menorrhagia.
With menorrhagia, every period you have causes enough blood loss and cramping that you can't maintain your usual activities. If you have menstrual bleeding so heavy that you dread your period, talk with your Des Moines gynecologist today.
Symptoms of Heavy Menses
The signs and symptoms of menorrhagia may include:
- Soaking through one or more sanitary pads or tampons every hour for several consecutive hours;
- Needing to use double sanitary protection to control your menstrual flow;
- Needing to wake up to change sanitary protection during the night;
- Bleeding for a week or longer;
- Passing large blood clots with menstrual flow;
- Restricting daily activities due to heavy menstrual flow;
- Symptoms of anemia, such as tiredness, fatigue or shortness of breath.
Tests and Diagnosis of Heavy Menses
Your Des Moines gynecologist will ask about your medical history and menstrual cycles and conduct a physical exam. He may recommend one or more tests or procedures such as:
- Blood tests;
- Pap test;
- Endometrial biopsy;
- Ultrasound scan;
Based on the results of your initial tests, your Des Moines gynecologist may recommend further testing.
Treatments and drugs
Drug therapy for menorrhagia may include:
- Iron supplements;
- Nonsteroidal anti-inflammatory drugs (NSAIDs;
- Oral contraceptives;
- Oral progesterone;
- The hormonal IUD (Mirena).
You may need surgical treatment for menorrhagia if drug therapy is unsuccessful.
Except for hysterectomy, these surgical procedures are usually done on an outpatient basis by your Des Moines ObGyn. Although you may need a general anesthetic, it's likely that you can go home later on the same day.
We want to be your Des Moines gynecologist; if you are suffering from heavy menses, call our office today at (515) 225-7201 to set up an appointment or to talk to any of our highly qualified staff members. We look forward to serving you.
Thank you for trusting us with your care!

subset: commoncrawl


text: I have RTFM and searched you tube but this particular technique has eluded me. I can choose velocity in the Hyper draw in Piano Roll but when I try to draw some fade on a selected note I see a thin green line but can find no info how this feature works. There was one you tube about just this but it was for Logic 8 and had instructions that were not in Logic 9, like choosing 'zoom in' from the Piano Roll "view" drop down, can't get the auto zoom in Logic 9 to do anything, and that is the main part off that explanation. Anyone want to try a short explanation of using the bars in the Piano Roll Hyper Draw to make a fade on one note?


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The search found 494 results in 0.02 seconds.
Although several studies have examined the association between religious involvement and physical functioning, there is no consistent empirical evidence concerning the true nature of the association. The Hispanic population is also surprisingly understudied in previous work. In this article, we employ seven waves of data from the Hispanic Established Populations for the Epidemiologic Study of the Elderly to examine the association between religious attendance and performance-based mobility trajectories among older Mexican Americans.
This paper proposes a theoretical framework and an empirical example of the relationship between the civic stratification of immigrants in the United States, and their access to healthcare. We use the 2007 Pew Hispanic Center/Robert Wood Johnson Foundation Hispanic Healthcare Survey, a nationally representative survey of U.S. Latinos (N = 2,783 foreign-born respondents) and find that immigrants who are not citizens or legal permanent residents are significantly more likely to be excluded from care in both the United States and across borders.
A large literature has documented that Hispanic immigrants have a health advantage over their U.S.-born counterparts upon arrival in the United States. Few studies, however, have disentangled the effects of immigrants' arrival cohort from their tenure of U.S. residence, an omission that could produce imprecise estimates of the degree of health decline experienced by Hispanic immigrants as their U.S. tenure increases.
Adolescent survival expectations are linked to a range of problem behaviors, poor health, and later socioeconomic disadvantage, yet scholars have not examined how survival expectations are differentially patterned by race, ethnicity, and/or nativity. This is a critical omission given that many risk factors for low survival expectations are themselves stratified by race and ethnicity.
This article investigates whether men's sexual behavior is influenced by the sex of their firstborn children and, if so, at what stage of firstborns' development this occurs. Using standardized data from 37 Demographic and Health Surveys (N = 61,801), I compare the sexual activities, sexually transmitted infection symptoms, and sexual ideologies of fathers with firstborn sons and fathers with firstborn daughters. I also explore whether fathers' attitudes mediate the effects of firstborn sex.
Despite evidence that first-birth timing influences women's health, the role of marital status in shaping this association has received scant attention. Using multivariate propensity score matching, we analyze data from the National Longitudinal Survey of Youth 1979 to estimate the effect of having a first birth in adolescence (prior to age 20), young adulthood (ages 20–24), or later ages (ages 25–35) on women's midlife self-assessed health.
Research on the relationship between social capital and individual health often suffers from important limitations. Most research relies on cross-sectional data, which precludes identifying whether participation predicts health and/or vice versa. Some important conceptualizations of social capital, like social participation, have seldom been examined. Little is known about participation and health in sub-Saharan Africa. Furthermore, both physical and mental health have seldom been tested together, and variation by age has rarely been examined.
Education has a large and increasing impact on health in America. This paper examines one reason why. Education gives individuals the ability to override the default American lifestyle. The default lifestyle has three elements: displacing human energy with mechanical energy, displacing household food production with industrial food production, and displacing health maintenance with medical dependency. Too little physical activity and too much food produce imperceptibly accumulating pathologies.
Researchers have documented widening educational gradients in mortality in the United States since the 1970s. While smoking has been proposed as a key explanation for this trend, no prior study has quantified the contribution of smoking to increasing education gaps in longevity.
Education is a fundamental cause of social inequalities in health because it influences the distribution of resources, including money, knowledge, power, prestige, and beneficial social connections, that can be used in situ to influence health. Recent studies have highlighted early-life cognition as commonly indicating the propensity for educational attainment and determining health and age of mortality. Health behaviors provide a plausible mechanism linking both education and cognition to later-life health and mortality.


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Details of Yamaha Keyboard Amp
Remote isn't so hot, I have observed much nicer! Before you select a system, you ought to make sure you know precisely what features and characteristics you're searching for. The machine is extremely light and has a compact design that makes it simple to carry around, particularly with the access to built-in carry handle. You might have the very best equipment on the planet but in case you can't get it there then it won't do you a great deal of good. Therefore, I got it without further testing.
The tone is really amazing. It sounded like a 20-year-old sound, making sense because this amp's been around for a long time. I've been into high-end audio for more than 20 years. With Amazon, if I disliked it or if it didn't work with my speakers it's an easy return and fast refund. Dual headphones supply you with versatility that typically requires several accessories so as to realize. Regardless of your tastes, it's undeniable your amplifier or monitor is an enormous portion of your keyboard total sound. You may tell it's a good state amp. however, it is as near tube sounding as SS gets.
You're going to get a very good warranty also on Toro products. I got a complete refund, no hassle. Many buyers choose this option because they don't have a lot of space to maintain a big piano only to find an acoustic sound. At $7000 it's VERY pricey and overpriced for the sector, but again look at the competition this piece is in precisely the same class with. Another excellent thing about this item can be its simplicity of operation.
1 fantastic case in point is the Motif XF6. When you've determined what you require, narrowing your choices down to a last choice is a far easier process. At just about 26.7 lbs, it's a lightweight option for the majority of its counterparts. It's a reverb feature, which may be used in four modes, and in addition it has a chorus effect.
The DW717 is extremely sturdy and has a superb design. It's challenging to describe within this narrative. There's no mystery in regards to recognizing the main characteristics in a digital piano. In fact, I doubt whether there is any true science to this.
For those who have a possiblity to Audition one, I strongly suggest it. With all this gear available, there's no doubt which you can find what you're searching for. It's quick and simple to use. It's quite amazing really and something you would need to experience. First let's take a peek at its features and specifications. It is among the best saws which are available on the market today. Best I've heard or owned.
If you believe the S2000 is at least as good, feel again. I must say that Amazon is the very best inside this regard. It's a clearing with as much as 22 inches, and a throwing distance as much as 30 feet. It sports a 21 in. clearing width, together with a 30 foot throwing distance. A great home-guitar amplifier. In spite of ear to speaker.


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Character Overview:
Sherlock Holmes is a fictional private detective created by Arthur Conan Doyle, and this character is played by Benedict Cumberbatch in the BBC television series Sherlock (Gatiss & Moffat, 2011). As a consulting detective widely reputable for solving crimes, Sherlock is portrayed as smart, attentive to detail, intuitively clever, and consequentially often condescending and arrogant. That said, albeit a great reputation for intelligence and problem-solving, Sherlock tends to be emotionally cold, distant, insensitive, and tremendously unempathetic when it comes to interpersonal relationships or social interactions. In fact, throughout Sherlock, various characters comment that he is "a bloody psychopath", an "insensitive prat" and "without a heart" (Gatiss & Moffat, 2011-2014). However, given the buzz about Sherlock's notorious reputation of being "a high functioning sociopath", does this character really meet diagnostic criteria for such a statement? This case study will closely analyze whether Sherlock clinically meets the criteria for an antisocial personality disorder as compared to an autism spectrum disorder, followed by a detailed analysis of Sherlock's interpersonal tendencies through an attachment theory lens. Implications for relevance to modern mental health diagnosis and practice will be discussed.
Autism or Sociopathy?
Though many fans jokingly subscribe to Sherlock's self-proclamation of being "a high-functioning sociopath", I personally do not believe that Sherlock's character meets the criteria for an antisocial personality disorder, and I think his behavior and tendencies more closely match that of an individual with autism spectrum disorder (ASD). Throughout the show, Sherlock meets various descriptors for autism such as being particularly knowledgeable about topics of interest, lacking general social cues but without malicious intent, preferring familiarity and orderly consistency for certain things, and other such related criteria. Given this, seeing as ASD encompasses many of these tendencies (American Psychiatric Association, 2013), I would argue that Sherlock more closely meets the criteria for autism rather than any form of sociopathy. Briefly, the DSM-5 describes criteria for ASD as follows:
- Persistent deficits in social communication and social interaction across multiple contexts (i.e. deficits in social-emotional reciprocity, deficits in nonverbal communicative behaviors used for social interaction, deficits in developing/maintaining/understanding relationships).
- Restricted, repetitive patterns of behavior, interests, or activities, as manifested by at least two of the following:
- Insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal/nonverbal behavior (e.g. rigid thinking patterns, difficulties with transitions, extreme distress at small changes)
- Highly restricted, fixated interests that are abnormal in intensity or focus (e.g. strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests)
- Hyper- or hypo-reactivity to sensory input or unusual interest in sensory aspects of the environment (American Psychiatric Association, 2013)
These criteria must be present along with clinically significant impairment to social, occupational, or other important areas of current functioning. They also cannot be better explained by an intellectual disability, which Sherlock definitely would not meet.
Lestrade: "I suppose he likes having the same faces back together. It appeals to his… his…"
John: "Aspergers?"
-Hounds of Baskerville (2012)
Notably, John also mentions Asperger's in an episode of the show. Clinically, Asperger's syndrome has since been integrated into the general description of autism spectrum disorder.
Contrarily, the DSM-5 criteria for antisocial personality disorder (which is now the umbrella category for both psychopathy and sociopathy) are as follows:
- A pervasive pattern of disregard for and violation of the rights of others, occurring since age 15 years, as indicated by three or more of the following:
- Failure to conform to social norms with respect to lawful behaviors, as indicated by repeatedly performing acts that are grounds for arrest
- Deceitfulness, as indicated by repeated lying, use of aliases, or conning others for personal profit or pleasure
- Impulsivity or failure to plan ahead
- Irritability and aggressiveness as indicated by repeated physical fights or assaults
- Reckless disregard for safety of self or others
- Consistent irresponsibility (repeated failure to sustain consistent work behavior or honor financial obligations)
- Lack of remorse (i.e. indifference to or rationalizing having hurt, mistreated or stolen from another) (American Psychiatric Association, 2013)
That said, though Sherlock may seem to meet a few of the criteria for antisocial personality disorder, I would argue that his lack of remorse and general unorthodox approach towards social relationships can more closely be attributed to unawareness rather than malicious intent. It is discussed in Essentials of Psychiatric Diagnosis that a common indicator of antisocial personality disorder in earlier childhood would be injuring animals without remorse (Frances, 2013). Contrarily, Sherlock throughout the first three seasons of the show shows a great attachment to the insinuated pet dog from his childhood, Redbeard. In addition, it is arguable that his friendship with John and his devotion to protecting his loved ones from Moriarty—such as faking his death to protect Mrs. Hudson, Mycroft, and Lestrade in "The Final Problem"— also disproves prevailing traits typical of someone with antisocial personality disorder.
"So if I didn't understand I was being asked to be best man, it is because I never expected to be anybody's best friend. and certainly not the best friend of the bravest and kindest and wisest human being I have ever had the good fortune of knowing. John, I am a ridiculous man. Redeemed only by the warmth and constancy of your friendship."
-Sherlock to John, The Sign of Three (2014)
From an Attachment Perspective:
The linked scene above is from Sherlock episode "The Hounds of Baskerville" (Gatiss & McGuigan, 2012). Sherlock and John have been investigating a rumored gigantic hound, which later transpires to be a projected hallucination based on chemicals in a synthetic fog. However, in this particular scene, Sherlock had just stood in the synthetic fog, and believes that he had actually scene a gigantic hound, which defies all scientific reason and is thereby severely unsettling to him. Contrarily, John did not see the hallucination, and attempts to have a regular conversation with Sherlock about next steps in the investigation.
"I've always been able to keep myself distant. Divorce myself from feelings. But you see? Body's betraying me. Interesting, yes? Emotions. The grease on the lenses. The fly in the ointment."
-Sherlock to John, Hounds of Baskerville (2012)
In this scene, one principal aspect of Sherlock's response to his emotional distress is that he is determinedly suppressing his visceral reactions and focusing exclusively on his rational mind, trying to cognitively explain his thinking and why it is reasonable to be distressed. Though the rational mind indubitably plays an important role in emotional tolerance (Wallin, 2007; Howe, 2013), it is noteworthy how Sherlock seems to, in turn, neglect his emotional mind, and does not allow himself to sit with vulnerable discomfort without intellectualizing his experience. This is a tendency that is very central to Sherlock's character, and arguably intimately related with Sherlock's attachment style.
John: "Now, why would you listen to me? I'm just your friend."
Sherlock: "I don't have…friends."
–Hounds of Baskerville (2012)
It is notable to observe Sherlock's relational coping mechanisms when he is feeling unsafe. As overviewed in Attachment in Therapeutic Practice, individuals can develop ways to regulate their affect through what best works for achieving their needs (Slade, 2014). Throughout the show, John is Sherlock's closest friend, given that Sherlock has few friends, intimate connections, or family relations. In this scene, we can see Sherlock emotionally disconnecting from John, nonverbally avoiding eye contact and positioning himself away, while John is leaning forward and prompting him. It is also later revealed in the show that Sherlock's childhood comprised of him always being second best to his older brother, Mycroft, and always being alienated at school due to being "the eccentric kid". Given this background, it is illuminating to employ an attachment lens on Sherlock's response to John, because part of Sherlock's learned reflexes from his childhood seem to have been to avoid social connections since he was so frequently belittled or alienated by other people.
Additionally, it can be observed that Sherlock's cognitive tendencies are to deflect emotional experiences and rely heavily instead on intellectual reason. For instance, when experiencing fear and uncertainty in this scene, Sherlock avoids opening up about his experience of vulnerability, choosing instead to rely heavily on logical explanations for his distress and also suppressing his clear fear from seeing a gigantic hound. At the end of the scene, he compulsively analyzes a nearby family, capitalizing on his affinity for detail so as to avoid coping with his true emotional and visceral feelings. During all of this, as well, Sherlock is deliberately pushing John away, and at the end of the scene, he also abrasively says "I don't have…friends", further distancing himself emotionally from his closest social connection in this situation.
Given this discourse, I would suggest that Sherlock has a dismissive attachment style. As overviewed in Attachment in Psychotherapy, dismissive attachment tendencies include turning away from relational opportunities, seemingly discounting the importance of social support, and superficially minimizing social relationships (Wallin, 2007). It is also important to note how individuals with dismissive attachment styles are not necessarily truly indifferent towards relationships, but that many times their seeming indifference is stemming from unmet needs in childhood, with resulting dismissive tendencies as an adaptive defense mechanism (Howe, 2013).
Moreover, as described in Attachment Across the Lifecourse, "psychological independence feels more comfortable than emotional closeness" for individuals with dismissive attachments in adulthood (Howe, 2013, p. 106). Key characteristics of avoidant attachment types include downplaying the importance of attachments and minimizing feelings of vulnerability or emotional need (Wallin, 2007). As exhibited in this scene, Sherlock intuitively distances himself from John, denying the need for social support and verbally expressing that he does not have friends.
In addition, cognitive tendencies for dismissive attachment styles include presenting oneself in inflated or grandiose terms, and heavily relying on talents, successes and achievements to measure contentment as a form of defensive self-enhancement (Shaver & Mikulincer, 2004). These propensities can be observed in Sherlock's behavior as well. Consistent throughout the show, Sherlock is repeatedly shown to gloat in his successes, feeling very self-confident, often to the point where characters speculate that if he believed in a higher power, it would be in himself (Gatiss & Moffat, 2012). It can also be noted, therefore, that Sherlock uses his intellectual prowess to measure his own sense of worth. In this scene, when faced with a problem in the investigation, Sherlock turns to analyzing the table next to them in the restaurant, capitalizing on his logical and inferential abilities which have brought him so much reputable fame in the past. He is likely turning to this because he does not want to face his emotions of fear and vulnerability, or expressively explore such feelings with his closest friend.
Furthermore, it is also interesting to notice how Sherlock feels the need to prove himself during this scene, contradicting John's suggestions that he may simply need support. Notably, he forcibly analyzes the table next to them, saying "See, John, like I said, I am fine" (Gatiss & Moffat, 2012).
I close this case study instigating discussion around how autism and other related developmental disorders could play a role in attachment and mental health treatment. If Sherlock genetically lacks social inclinations compared to the general population, and neurologically does not process relationships the same way that other people in society might, how could this have influenced the development of his dismissive tendencies and general attachment inclinations? What is more, how would therapeutic treatment plans change if this additional information is provided about a client presenting similar to Sherlock?
Distinguishing between autism and antisocial personality disorder is another important point of discussion from this case that relates importantly to clinical challenges of differential diagnosis and recognizing key discrepancies that define an individual's presenting context. It also notions how oftentimes media can promote inaccurate representations of mental illness, given that Sherlock himself jokingly refers to himself as a "sociopath", automatically perpetuating stigma and presumptions that accompany such a label. I therefore want to highlight the importance of seeing beyond a diagnosis and recognizing the individual differences and unique life circumstances of every client and patient presenting for mental health treatment. Labels and misdiagnoses are far too common today, and approaching clinical diagnosis with a grain of salt can make a world of difference for a mental health practitioner.
In conclusion, Sherlock Holmes is among the most portrayed and reenacted fictional characters to date, and the BBC TV series Sherlock arguably portrays this famed character with dismissive and avoidant attachment tendencies. Attachment-related approaches for this client would be very interpersonally focused, and such a clinician could find ways to explore familial backgrounds, developmental history, and emotional underpinnings behind Sherlock's tendencies to downplay social connection and shut down his emotional mind in the face of vulnerability. Sherlock's character is thus a great illumination regarding attachment tendencies and cognitive defensive strategies, as well an example of the compelling and complex layers behind clinical diagnosis in the mental health field.
As a disclaimer, this case study focuses exclusively on the character of Sherlock Holmes as portrayed by Benedict Cumberbatch in BBC's Sherlock series. I am not analyzing any content from Doyle's books or any other portrayed versions of the character.
Have any reactions, comments or questions regarding my opinion on autism vs. antisocial or want to discuss further? Please message me, as I would love to hear your thoughts on this case study.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. (DSM-5) Washington: American Psychiatric Association, 2013.
Bennett, S., & Nelson, J. K. (Eds.). (2010). Adult attachment in clinical social work: Practice, research, and policy. Springer Science & Business Media.
Bettmann, J. E., & Jasperson, R. A. (2010). Anxiety in adolescence: The integration of attachment and neurobiological research into clinical practice. Clinical Social Work Journal, 38(1), 98-106.
Farber, B. A., & Metzger, J. A. (2009). The therapist as secure base. Attachment theory and research in clinical work with adults, 46-70.
Fonagy, P. (1998). Attachment theory approach to treatment of the difficult patient. Bulletin of the Menninger Clinic, 62(2), 147.
Frances, A. (2013). Essentials of psychiatric diagnosis, revised edition: Responding to the challenge of DSM-5®. Guilford Publications.
Gatiss, M. (Writer), & Lovering, J. (Director). (2014). The Empty Hearse (Television series episode). In S. Vertue (Producer), Sherlock. London: BBC Worldwide.
Howe, D. (2011). Attachment across the lifecourse: A brief introduction. Macmillan International Higher Education.
Jacobs, J., & Mollborn, S. (2012). Early motherhood and the disruption in significant attachments: Autonomy and reconnection as a response to separation and loss among African American and Latina teen mothers. Gender & Society, 26(6), 922-944.
Love, K. M. (2008). Parental attachments and psychological distress among African American college students. Journal of College Student Development, 49(1), 31-40.
Mohr, J. J. (2008). Same-sex romantic attachment. In J. Cassidy & P. R. Shaver (Eds.), Handbook of attachment: Theory, research, and clinical applications (pp. 482-502). New York, NY, US: The Guilford Press.
Simpson, J. A., Collins, W. A., & Salvatore, J. E. (2011). The impact of early interpersonal experience on adult romantic relationship functioning: Recent findings from the Minnesota longitudinal study of risk and adaptation. Current Directions in Psychological Science, 20(6), 355-359.
Vertue, S. (Producer). (2010). Sherlock [Television series]. London: BBC Worldwide.
Wallin, D. J. (2007). Attachment in psychotherapy. Guilford press.
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Disclaimer: This character, their photos, and storyline references are all copyright by BBC One and Arthur Conan Doyle. All information and content presented in this assessment are solely analyzed for general information and reference purposes.
© Post material by Juliann Li and The Character Clinic, 2019.
All rights reserved.


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About Us
We supply fully qualified, experienced staff who strive to provide excellent care. Our staff are trained to use state-of-the-art computer technology, including SOE Exact and R4 Dental programmes. We provide regular training to ensure our staff's competence, professionalism and expertise to provide care and support to the team at your establishment.
Our skilled and friendly team will ensure that you receive the best possible comprehensive service we can provide. Feedback is greatly welcome to help maintain and grow our team to meet your needs and expectations.
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Outrage! Sheer outrage I tell you!!!
What is this town coming to?
Yesterday, hubby and I went for a walk along the canal and back across the field behind the Priory. This is a walk we take most days (when I am able), as it is not too far for me to trundle without being in too much pain.
Well, we were strolling along the river in the centre of the field, discussing life, the universe and everything else, when suddenly, three massive dogs came charging towards us barking and snarling! It was like something out of a horror film – Resident Evil springs to mind! Two very large Hounds of some type (similar to Great Danes, but slightly smaller) and a Grey Hound. There were, however, seven dogs in total! Two of the large Hounds, Two Grey Hounds, Two medium cross breeds and one tiny yappy thing. None of them were on a lead. They didn't stop barking or harassing us, while the two very rotund owners (who would not have been able to run and stop their dogs if they had attacked us, due to their sheer size), were shouting for the dogs to come back, but they were not listening at all.
I was terrified! I am not afraid of dogs and generally, while on a walk, they will come up to us and have a bit of a fuss. But, surely, dogs like this, should be kept on leads? If the owners are unable to control them, then, this should be a law. What would of happened if the dogs had attacked? Three dead dogs I imagine, by one way or another. My biggest fear here, was – what would of happened if I had children with me?
The rest of the dogs then began to race around, barking and generally harassing us, running to within inches of us, almost knocking us over. The owner, eventually, when she rolled up to us said "Oh, don't worry, they won't bite, they just like to talk". I fear this woman had a very low IQ. She owns seven dogs and clearly is unable to handle them. Does she not understand pack mentality?
These dogs would have attacked at any time if the owners had so wished and I firmly believe that if they were trained correctly, they would not have behaved so. The two owners were obviously the Alpha's with the seven dogs as a pack. The dogs will only do what the owners wish them to do, picking up on their scents and pheromones, as queue's for them to act.
We eventually got through the terrifying ordeal and returned to the safety of our home and as is the British cure for all terrifying moments, we had a cuppa.
While making said cuppa, we heard some loud and raucous Polaks shouting and singing down the street. We live directly on the main road, which is sometimes a nuisance, and have a large kitchen window. Looking out of the window to identify this new disturbance, the band of brigands ambled along, special brew cans in hand, while one of them decided to go into the garage across the road and take a piss up the side of a very expensive looking four wheel drive. Clearly visible to all and sundry who happened to be passing. Lovely.
I despair!
Interestingly, I had a response from the owner/keeper/walker of the dogs mentioned above and I have attached it here, as well as my response to her regarding the dogs. Enjoy and feel free to join in with your comments around this kind of irresponsible, reprehensable behaviour! Oh, and I have left the spelling and grammatical errors as she wrote it.
Furious and highly offended
Submitted on 2012/08/07 at 3:50 pm
In response to your dramatic and very exaggerated post entitled 'Rabid dogs and Pissing Pollacks'
I would firstly like to thank you for your wonderful description of my partner and I, "…very rotund…sheer size…very low IQ" how non-judgemental and benevolent of you!
I noticed several areas of extreme exaggeration in the post, which I feel I should bring to your attention. I have never owned seven dogs, nor do I intend to, there were five, of which, four belonged to me at the time. For your information, the two larger dogs are eight month old lurcher puppies – nowhere near the size of Great Danes, one of the medium crossbreeds is also a lurcher, a petite female, and the other one a collie cross, and the "tiny yappy thing" (I happen to agree with you on that statement) is a Jack Russell. None of the dogs were snarling at any point, they were barking nervously, which is a sign of their uncertainty about two outsiders approaching their pack. "A scene from a horror film – Resident Evil.." – I can only ascertain from that statement that your experiences of horror films are very limited, or that you have a flare for hyperboly. I foster dogs for a local dog rescue, and have rescued and rehabilitated several dogs over a significant period of time. I understand pack mentality and how dogs react to energy. I should point out that the dogs were reacting negatively and with an obvious dislike to the energy being projected by you, and was nothing to do with my also "very rotund" partner and I.
In my opinion, the term "harassing" is rather extreme and unnecessary. My response to your silence and rudeness, after I gave my appologies as I saw that you were uncomfortable with being greeted in such a way was "Honestly, they wont bite or hurt you, they just like to talk". This was factual. The dogs did not attack, or bite, or in fact touch either of you at any point, and would never do so, as they are not, and have never shown even a small amount of aggression. I believe that if you did in fact have children with you, the dogs would have reacted in a much calmer way, as children tend to project calmer and more positive energy than adults. I have two children, both under the age of five, who are able to do basic training with the dogs, and get them to obey basic commands. If you had sufficient knowledge of dogs, you would understand that barking is an expression of many things, aggression being just one. As for the dogs being trained correctly, part of my role as a rescuer is to train the dogs, which is an ongoing process. The dogs are all safe to be off their leads, and would not have been running free if this was not the case.
I would like to finish by apologising again, that you were uncomfortable in the situation, however, I believe that you have exaggerated this almost beyond belief in your own mind, and I think that frankly, you are ridiculous. That particular field is very popular with dog walkers, as you know, so if encounters with multiple barking dogs is frightening for you, might I suggest you take your walks in other areas.
Lastly, I find your references to Polish people as "Pollacks" offensive and racist.
Congratulations on being such an admirable and well-rounded human being.
Here is my reply.
Dear Furious and Highly Offended,
Madam, I am responding to your comments left on the Contact page of my website. Unfortunately, as you used a fake email address and left no name, I am unable to address you as anything but Madam. In all honesty, I do find it amusing that my blog has elicited such a response from you. That you should be furious and highly offended was exactly my intent!
Firstly however, I must thank you for taking the time out to read my blog as it is on the World Wide Web and is open for the public to see, that is what it is there for. The fact that you have taken the time to respond yet not leave your name or email address, proves to me your guilt in this instance, as those with a clear conscience would be happy to state their name.
I should also say that I do think that your chosen vocation of rescuing and rehabilitating dogs is a wonderful thing to do. As an animal lover myself, I find this a noble cause. (My own pets, of which I have had many, were mostly rescues and strays – apart from the two guard dogs we owned while living in South Africa. Both were thoroughbred Alsations. This is how I was able to identify the intent of your dog, as I have witnessed attack dogs in action). Unfortunately, this is where you have let your profession down, by your total lack of responsibility surrounding the vicious dog on the date in question. You should either go on further training or make a career change as you are clearly failing at rehabilitating an animal that needs to be kept away from the public. You state that the dogs have never shown aggression before – well on this date, they most certainly did. You should be ashamed of yourself!
The only mistake that my husband and I made on the day, was not calling the dog warden.
Basically, YOU are wrong and the action you failed to take on the day was wrong. Legally, you have broken the law and I know that you are well aware of this. Your dog's behaviour and thereby your own, as a responsible dog owner/carer was illegal. I will refer to you several documents and websites for rescuing/rehabilitating dogs and from your own admissions above, you are probably in contravention of a number of them.
Town Police Clauses Act 1847:
Under this law, Section 28, (except for Greater London area-see below) it is an offence for any person in any street to let an unmuzzled ferocious dog be at large, to the obstruction, annoyance, or danger of the residents or passengers.
It is also an offence to set on or to urge any dog or other animal to attack, worry, or put in fear in any person or animal. The Act defines the meaning of 'street' shall extend to and include any road, square, court, alley, thoroughfare (public road going from one place to another) or public passage. (taken from www.endandgereddogs.com).
In both my husbands and my opinion, this was a ferocious dog and should not have been let lose on/in a public place. We were forced to stop walking and felt the need to stand perfectly still, unable to speak in fear of the dog attacking. It barred our path, bared its teeth, growled, barked and snarled, with curled lips. I think, as you were at least 100 meters (if not more) behind the dog with the wind blowing from the west (the direction you were walking from), you probably could not hear.
With regards to your criticisms of my blog and style of writing, as I choose to practice as you put it "Hyperboly" or Hyperbole (as it is actually spelt) and as a writer, practice poetic license. I did not write this blog in jest. The account of the fear that I personally felt is true and accurate. As I am diagnosed with Bi-Polar disorder, I often suffer from agoraphobia and venturing out on my own can be difficult. My husband and I have been walking across that field over the past year and not once have we encountered such a vicious animal. The situation on the day above, did scare me and as I have seen you around the vicinity since said day, I do feel rather threatened by a further encounter. Your reference to my experiences of horror films being limited is a direct verbose attack at my own entertainment choice. As it so happens, horror is my favourite genre of film, art and literature as, if you had taken the time to look at the rest of my website, you would, perhaps have noticed this. I could have en-likened the animal to Cujo or the Dog from John Carpenter's The Thing. I chose the dogs from Resident Evil as looking at a snarling mouth full of teeth brought the image into my mind.
My reference to your weight issues were to illustrate the fact that if the dog had attacked or bitten, you would not have been able to reach the part of the field we were in. Your calls to the dog and indeed dogs to heel were ignored by ALL of the animals that belonged to you or were under your care at the time – of which, there were SEVEN. I could have used the words "obese", "overweight" or "fat". I felt rotund described you both perfectly. As an ex-fattie myself, I do not feel that these terms are derogatory in any way as I call myself fat.
Your words "They won't bite or hurt you, they just like to talk" was by no means an apology. It was an excuse. An excuse to brush away the behaviour of an animal that you clearly have not rehabilitated or trained correctly. Neither my husband or I dared to talk to you after we eventually managed to walk along the side of the river, for fear that the dog would attack and of course the abuse and protest that you would no doubt have put forth if we were to speak our minds and tell you to leash the dog. Again, our only mistake on the day was not contacting the dog warden. You state "harassing" is extreme and unnecessary, well, I beg to differ. The dog did not give in its barking, snapping, snarling, growling; the two greyhounds or lurcher's as you insist they are, were running around the field at such a mad pace, they barrelled into us a couple of times and we had to side step them. THAT Madam, is harassment. Harassment (/həˈræsmənt/ or /ˈhærəsmənt/) covers a wide range of behaviors of an offensive nature. It is commonly understood as behaviour intended to disturb or upset, and it is characteristically repetitive. In the legal sense, it is intentional behaviour which is found threatening or disturbing. It was most definitely threatening and disturbing behaviour!
We were minding our own business, your dogs were not. While we were stood frozen in the middle of the field, the rest of your dogs took on the pack nature that they so easily slip into as is their psychology. Having seen Wild Dogs in action in the bush, they were circling around and behind us. The vicious dog obviously being the Alpha and the rest darting back and forth to intimidate and create fear. I am sure by this time, the dogs did pick up on a "negative energy" around us, to use your term. That negative energy being FEAR. (I believe the negative energy you are intoning in your response above is probably aimed at our different style of dress and that we follow an alternative lifestyle). The dog appears to have issues and will follow the lead of its owners (or not). It is a dog. Not a human. No human can predict the nature or reaction of a dog to any situation. How can two people who have just got married and are taking a romantic walk, possibly have negative energy around them?
As the psychology of the animal is in question here, I will refer you firstly (again), to the Endangered Dogs website and secondly, the Kennel Club website on the following points:
Under control:
Safe and secure – Keeping your dog under the control of a competent adult is your responsibility. Regularly check your dog's collar, lead, head collar, harness, muzzle etc – do they fit properly and is any item excessively worn? Never let your dog out unattended. Make sure your garden is secure and your dog cannot escape-check your gates and fencing regularly, especially following adverse weather.
Never leave children and dog(s) alone together without adult supervision-adult (a responsible adult) supervision is essential-asking or telling a child to stay away from a dog is not good enough. When you are out and enjoying a walk with your dog-do remember that not everyone is comfortable around dogs, for many different reasons, please be considerate at all times.
Barking - Excessive barking can cause a problem with your neighbours who may lodge a complaint with your local authority (council). Complaints are investigated and a 'Noise Abatement Notice' can be issued. If you have a problem with your dog barking a lot – please take advice.
Livestock – Your dog should never be allowed to worry livestock. Under the Dogs (Protection of Livestock) Act 1953 it is a criminal offence if a dog is at large (not on a leash or otherwise under control) in a field or enclosure which contains sheep. Worrying livestock also includes attacking livestock or chasing livestock in a way which may reasonably be expected to cause Injury or suffering. Livestock includes cattle, sheep, goats, swine, horses and poultry such as domestic fowls, turkeys, geese or ducks. Injury doesn't have to have taken place for the offence to have occurred.
Civil action – Under the Dogs Act 1871 a complaint can be made to the Magistrates Court that a dog is dangerous and not kept under proper control. If it appears to the court that the dog is dangerous, the court may make an order directing the dog be kept under proper control by the owner, or destroyed. It is important to note that the law can be applied to both public and private places.
Criminal offence – Under the Dangerous Dogs Act (DDA) 1991 – Section 3 as amended, it is a criminal offence for a dog to be 'dangerously out of control' in a public place, or a private place where the dog is not permitted to be. This applies to all dogs of all breeds/types.
A dog shall be regarded as dangerously out of control on any occasion on which there are grounds for reasonable apprehension that it will injure any person, whether or not it actually does so – an aggravated offence (more serious) will have been committed if the dog, whilst out of control, injures a person. An injury doesn't have to be in the form of a dog bite, it could, for example, be from a dog enthusiastically greeting someone and knocking them over, or jumping up and scratching a person's leg, injury to a person is classed as an aggravated offence under the DDA.
Liability – Under the Animals Act 1971 you could be held liable to pay compensation in a civil action brought, for any damage caused by your dog. Liability rests with the keeper – the person in possession/in control of the dog at the time it caused damage. Conditions have to be met and there are exceptions from liability.
Local Restrictions – Under the Clean Neighbourhoods & Environment Act 2005 your local authority can/or may have already, introduced a 'Dog Control Order' (DCO) in their own public areas. These orders can relate to dog fouling, the keeping of dogs on leads, the number of dogs which a person may take on to any land or the exclusion of dogs from land.
Open spaces, parks etc in your area could become/may already be subject to a dog control order, limiting your use as a dog owner. You will need to be aware of any local measures currently in place and abide by them.
Dangerous Dogs Act 1991 (section 3)
It is a criminal offence (for the owner and/or the person in charge of the dog) to allow a dog to be 'dangerously out of control' in a public place, a place where it is not permitted to be, and some other areas. A 'dangerously out of control' dog can be defined as a dog that has injured someone or a dog that a person has grounds for reasonable apprehension that it may do so. Something as simple as your dog chasing, barking at or jumping up at a person or child could lead to a complaint, so ensure that your dog is under control at all times.
If your dog injures a person, it may be seized by the police and your penalty may include a prison sentence and/or a ban on keeping dogs.
There is also an automatic presumption that your dog will be destroyed (unless you can persuade the court that it is not a danger to the public, in which case it may be subject to a control order). You may also have to pay a fine, compensation and costs.
Madam, The facts are:
1. The dog was unmanageable by yourself and therefore deemed dangerous.
2. The dog blocked our passage, bared its teeth, growling, barking and snarling.
3. You could not call the dog to heel.
4. The rest of the pack were also uncontrollable.
5. You did not apologise or make any attempt to leash the dog or even scald it for the behaviour. I do not accept the "They won't hurt you…" statement as an apology. In fact, it was a non-apology apology and for your benifit, here is the meaning: A non-apology apology is a statement that has the form of an apology but does not express the expected contrition. It is common in both politics and public relations. It most commonly entails the speaker saying that he or she is sorry not for a behavior, statement or misdeed, but rather is sorry only because a person who has been aggrieved is requesting the apology, expressing a grievance, or is threatening some form of retribution or retaliation.
An example of a non-apology apology would be saying "I'm sorry that you feel that way" to someone who has been offended by a statement. This apology does not admit that there was anything wrong with the remarks made, and additionally, it may be taken as insinuating that the person taking offense was excessively thin-skinned or irrational in taking offense at the remarks in the first place.
I myself, in a similar situation, would have ensured that I approached the people and apologised profusely. You did not. By doing this, you showed a total lack of concern or regard for other people and their feelings towards vicious barking dogs. You are, in your own words "an admirable and well-rounded human being". Pun intended.
Further to this, the fact that you allow your children, under five, who are able to give the dogs "basic commands", clearly shows a lack of responsibility to your parenting skills as well as the commitment to your profession. At www.oncelovedrescue.org.uk I found the following statement:
We prefer foster homes without children, but we do place dogs into homes with children as long as they are over the age of 8 years old. Please note, no child must ever be left unsupervised with a foster dog.
This of course, is your choice and they are your children. But, if you are fostering a dog and you don't know the history of it, I wouldn't leave your children alone with it. Just my opinion.
I also noticed this week in the Guardian, a couple of letters, featured on AA Grundi's page, referring to instances of dogs not being on leads who were causing harassment to people and other animals. I am not implying that these were your dogs, just highlighting a prevelant trend in the area. I do believe that this is the reason the act above was put into place. http://www.worksopguardian.co.uk/community/readers-letters
It is time that irresponsible dog owners take back the responsibility they have to others and to their dogs. It is time that we, the citizens who do not own dogs, begin to enforce the laws pertaining to dog control, by contacting the local Dog Warden or Police.
I will NOT change where I walk, as it is a public field and I live just around the corner. Why should I change my walking area, when you could quite easily put a lead onto the dog in question and stop any harassment it may or may not cause. I have as much right as anyone living in this town to traverse that field and would like to do so in safety. While your pack is on the lose, my life and others' are at risk. Take responsibility for your animals and your EPIC FAIL at training them.
Oh and with regards to the "Pollack" reference – I should have written "Polak" and have since changed it. However, I shall direct you to a number of discussion boards, which notes that the Pole's use this term amongst themselves. As my husband works with many Pole's, he hears this on a regular basis. I am by no means racist, fattist, dogist or any "ist". The reason for this gripe was that the man who urinated outside my kitchen window on the main street was polish. This is not the first time that I have seen such behaviour in this town. It was also broard daylight. This is just one further example http://www.worksopguardian.co.uk/news/local-news/drunk-man-caught-short-on-camera-1-4021064
I apologise to any Polish People who I unintentionally offended.
In closing this piece, I draw your attention to a Welsh Proverb;
Three things it is best to avoid: a strange dog, a flood and a man who thinks he is wise.
May you make the right decision.
Blessed Be
Other references and websites used include:
www.scribd.com specifically referring to http://www.scribd.com/doc/13073172/Vicious-Dogs-The-Antisocial-Behaviors-and-Psychological-Characteristics-of-Owners which was originally published in the Journal of Forensic Sciences in March 2009.


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Even more effective than the Magna Carta.
In an effort to try to boost monarch numbers, many American gardeners began planting milkweed in their gardens to give the butterflies a place to eat and bang. But despite this altruistic planting of butterfly no-tell motels, monarch populations kept declining, sometimes at an even more rapid rate. What gives, weeds?
Well, these well-intentioned gardeners would have helped ... if they hadn't planted the wrong goddamn weed. Not all milkweed is created equal, and many gardeners planted tropical milkweed, a species which kills butterfly ambition. So rather than continue the migration (which is necessary to their life cycle), the monarchs would just settle down in their little milkweed patches and never leave, sort of like that star quarterback who ended up back in his parents' basement after dropping out of college.
"If it hadn't been for my bad knee and those 12 DUI arrests, I could've gone pro."
The most ridiculous part is that there are 20 different varieties of milkweed that are A-OK for monarchs, but humans still managed to find the one that's terrible for them, which could mean no more cool science projects. Think of the children!


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{Sugar Scrub Recipe}
Here's the Sugar Scrub Recipe I used for the baby shower! 1 cup brown sugar 1 cup white sugar 1 cup vegetable oil 2 1/2 tbsp. vanilla extract 2 tbsp. nutmeg 2 tbsp. cinnamon 2 tbsp. ginger In a mixing bowl Mix together all of the ingredients, except for the vegetable oil. Add in the vegetable oil a little at a time, stirring the mixture as you go, the consistency should be thick. smells like a Yummy Apple...Read More
$5 Nest Definition with Bird Vinyl Decal on GroopDealz!!
{ThisNest definition with Blue Bird} is sure to make a perfect addition to your home decor. To purchase your Nest definition Decal for only $5 with $1 shipping head over to...Read More
{Super Cute baby boy shower}
Let me just say I'm so excited to share the details of this {Super Cute Baby Boy Shower}that I threw for my best friend!! My cute friend wanted a modern contemporarydesign {I was informed that I couldn't use any sports or dog themes} YIKES for me… I really had to dig deep to please the prego lady! I was so thrilled to have stumbled upon Hostess with the Mostess where I found so many A-DOR-A BLE ideas!!! I fell in love with this Alphabet Baby Shower Collection...Read More
{A+ Teacher Appreciation Apple Vinyl Decal with Ribbon on GroopDealz}
Teacher Appreciation day is coming soon May 3rd… Show your Teacher your appreciation with this A+ gift! To purchase your A+ Teacher Appreciation Apple Vinyl Decal that {includes} cute ribbon for only $2 head over toGroopDealz *I purchased my Hand Sanitizer@the local Super Store for...Read More


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Why You Should Save For Marriage
Save For Marriage – The Pros
Possibly, you are planning for a wedding around the corner. Then you should be aware of the importance of finances. Save for marriage; you will not be sorry. Read on for more information.
If all you want to do is to make it legal, marriage cannot be simpler. A quick visit to the City Hall and you will be set when your turn comes. Fast, simple and super easy. Feel pressured to put on a celebration? Don't do it unless this is what you really want, for the both of you, and you better have the money ready.
You want some kind of a celebration at least? Try having some kind of a savings then. The more elaborate the affair, the more money you need; something that we can all have more of. Will your sweetie be happy with a simple back-yard wedding or does she want something more. Agree on this issue together before deciding.
No matter how you slice it, you cannot go wrong with savings in the bank. Unexpected expenses can come up and you will not be caught off guard. Your tidy little sum of savings can come to the rescue just in time. Always up to the limit and you may land in trouble at tricky times.
Treat this as an exercise that you can both be up to speed with and don't get too serious. Use good judgment, be prudent and start planning like a couple of grown-ups; you will not be sorry. You will be glad you did.
Save for your marriage; your spouse will love you for this dependability and reliability. Show that you care and prove your worth. What a great way to begin a new life together.
In order to really get the answers to your question, I highly recommend you go straight to the net's leading site about this issue here. Go there now!: save marriage, marriage help and save my marriage


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LD Blue Granules
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Passion seems to be everyone's favorite buzz word these days and it's applied to all sorts of activities and industries - perhaps with too much nonchalance.
This is not the case with Detroit Autorama.
The automotive industry is teeming with dedicated and passionate individuals, but there is nothing like the connection between an owner and their personal car – particularly when said owner has poured weeks, months, and often, years, into crafting a vehicle to embody their unique creative vision.
Customs and Hot Rods represent the pinnacle of bespoke automotive excellence - and a real labor of love. Autorama is where all of the creative energy meets up for camaraderie and competition in equal measure, creating a unique proving ground for master of the craft. The show began in 1964 and has grown to be known as "America's Greatest Hot Rod Show". Builders travel from all over the country to the Motor City to show off their projects, share the stories of their build, and take notes on the latest trends to carry back to their own workshops. The top prize is the coveted Ridler award, named after the show's original promoter, Don Ridler, and it is given to the car winning best in show.
While the Ridler award is the greatest honor, the show's famous short list – the Pirelli Great 8, has become a mark of distinction itself, garnering attention from both international and local press at the Ridler's Ball, where industry influencers, corporate heads and lovers of all things automotive gather together to celebrate the art of Hot Rods and custom cars. The Great 8, developed together with Pirelli and Autorama officials, gives special recognition to the best of the best – and underlines Pirelli's appreciation for creativity and craftsmanship in automotive.
The world of Hot Rods and customs carves out a very special and distinctive niche in the American automotive landscape. No other aspect of the industry is so hands-on, detail-oriented and passion driven. The trend most likely started in California sometime in the 1930s, picking up in popularity as drivers found a "need for speed". Car geek lore says that this was something necessitated by the prohibition era, during which the underground trade and production of alcohol in the US made super-fast cars obligatory for those trying to outrun the law.
Prohibition came and went, but the practice of modifying cars continued and expanded. Traditionally, older US marques were the top choice for modification – and for most, this is still the standard. As with cars designed for racing, removing excess weight, changing engines and improving aerodynamics were, and are, standard practice. As builders got more deeply involved in their projects the attention to cosmetic detail grew and came to include stand-out color choices, graphics, and even the practice of giving projects a catchy name.
These vehicles moved far from the utilitarian and became alter-egos of their owners – expressing their aesthetic irrespective of the intent of the manufacturer and taking the artistic journey full circle: from drawing board, to assembly line and back to drawing board again.
A glorious re-birth indeed.
Detroit, of course, is the obvious location for such a gathering. As the original home of the "big 3" – Ford, GM and Chrysler, so its roots in the industry run especially deep. How apropos that the automobiles most closely linked with the American automotive tradition should return to the city of their conception to celebrate their masterful reincarnation?
Pirelli, while established as the worldwide leader for prestigious original equipment fitments, is, at its core, supremely linked with the creative process – whether it be in service of the manufacturer or the owner. What better expression of the creative lifecycle than the custom car? Now, with the advent of its color edition tires, the Pirelli has found a way to marry the two in perfect harmony – maintaining an exacting attention to manufacturer dictated performance, while giving owners the chance to use color as a medium for further personalization of their vehicle. Additionally, thanks to a wide portfolio of original equipment partners, Pirelli offers a diverse range of staggered fitment options, which provides the flexibility that builders need to achieve their signature look.
A marriage between technical and aesthetic – smart and beautiful, this is the Pirelli way forward for the future, and our newest connection to offer to passionate like-minded builders who dream of crafting their next dream car.


text: Scout Camps BSA Troop 718 regularly attends camps that help refine our skills and capabilities. Below is a partial list of camps. Florida Sea Base & Sea Base Bahamas Philmont Scout Ranch Camp Fiesta Island Camp Emerald Bay Camp Whitsett Schoepe Scout Reservation at Lost Valley Camp Three Falls Camp Chawanakee


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Friday, 1st February 2002 - Day 169
At last Daddy has got to update today as well. Sorry for the delay everyone and or those that are working through from the last update date they read sorry for repeating this on every page. Not many more missing now....
Well I have been weighed again and at last i have managed to put a little weight back on again. I am now back up to nearly my maximum weight to date at 4148gms or 9lbs 2oz. I must be getting enough calories inside me now and am doing proper demand feeding as well so I must be a clever little thing...This afternoon Mummy and Daddy were trained on how to use the oxygen at home and also how to resuscitate me in an emergency. Hopefully it will not come to that but better safe than sorry I suppose, and I will try my best to make sure that I keep breathing at all times and not give them any shocks.
Otherwise the rest of the day has been very uneventful really, briefly waking to be fed. Mummy still stayed by my bedside all day until 7pm until she went out with Daddy for a "Last Supper" pre me coming home and enjoyed their last night of freedom. The rest of the weekend they are going to spend in here with me making sure we have bonded enough to take me home on Monday. My last weekend here... Hooray...!!!!!
Sorry everybody no pictures for today, Mummy forgot to take any and was too tired to come back later in the evening to get some then.... I will leave you with an old picture of me the day after I was born and one from yesterday to compare to !!!!
Last Updated : 07/02/02. © The Newton Smiths 2002.


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This calculator is for educational and illustrative purposes only and should not be construed as financial advice. The results are only estimations. Please consult a qualified professional regarding financial decisions.
10 Pros And Cons of Mortgage That Might Surprise You
Buying Advantages and Disadvantages You Haven't Thought About
10 Hidden Pros Of Mortgage
Home mortgage interest is very tax-optimized compared to other ways you might borrow money to fund more consumption that you can afford.
The thing to keep in mind is that you pay tax on your other investments but capital gains on your PPOR are tax free. Then in retirement your PPOR does not affect your pension but any other asset does.
Real estate is an appreciating asset (with inflation), and that appreciation is tax free.
Buying takes the lead when you factor in retirement. I'll have a house paid off well before I retire, but somebody who's rented for their whole life will be spending a big chunk of their super/pension on rent.
Having a mortgage and working hard to pay that off as quickly as possible is forcing us with our wealth management, forcing us to save longer term.
Mortgages allow you to sell without selling. Simply get a new mortgage, and pull the equity out of the house. You may then be able to use the equity to fund an investment such as shares or a managed fund.
Average house prices have been consistently rising faster than average income in most developed countries.
The stress of having mortgage can be a good thing as it raises your budgeting standards dramatically.
Historically, rates are good right now, and when compared to 30 years ago, rates are exceptional.
The money you'll be using to pay back the loan in ten years will worth less than the same payment now while the rent payments will keep going up with inflation.
10 Hidden Cons Of Mortgage
Home ownership can be more expensive when you factor in rates, building insurance, cost of repairs, and strata fees. Maintenance on a property you own is as much "dead money" as rent. Council rates, water service rates, land tax, etc – all equally "dead money".
Since 2000, rental income has not even covered interest charges. No rational individual purchases an asset that generates a net negative yield – but clearly speculators have been pursuing capital gains instead.
If your primary residence has doubled in value since you bought it, from a practical standpoint, it probably just means that your real estate taxes have gone up. All of the gains that you have experienced is merely a gain on paper until you sell the property. If you chose to sell and hope to purchase another home in the same area, remember that the prices of other homes have risen too.
If more than 25% of your income will be going out in payments that will put strain on the rest of your budget. You won't be able to save and pay cash for furniture, cars and kids education.
Sick children, bad transmissions, prom dresses, high heat bills and pet vaccinations come up, and you won't make the extra payments. 97.3% of people don't systematically pay extra on their mortgages.
Paying extra towards your mortgage early is not an additional investment in your house. You already own the house so you are already exposed to any change in home value regardless of your mortgage size.
When buying people are betting on capital gains to get a decent ROI. You can never know for certain if the value of your property will increase, and you may find that you lose money on the property if you choose to sell.
Interest rates on mortgages are constantly changing and can increase.
When you buy house (and if you are like me ie normal bloke with normal working wages and partner stays at home) then you go under this massive debt and next 15-20 years of your life is spent on thinking how to reduce this loan and all your efforts are spent on that.
Young people today, in particular, haven't really grasped the high costs of borrowing in times of low inflation. Most of them are leaning towards the experience of their parents, who bought at times of high inflation when the debt was eroded very quickly and made very good gains because of high inflation.
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Showing 1-6 of 6
By: Catton, Bruce
Price: $35.00
Publisher: New York, Doubleday: 1952
Edition: Book Club Edition. 1
Seller ID: 20136
Condition: Very Good with no dust jacket
Spine is slightly faded and crumpled on top & bottom. Minor shelf-wear with bumped corners. . Book Club Edition. Vol. 1/3/2018. 8vo 8" - 9" tall View more info
By: Field, Ron and Robin Smith
Price: $39.00
Publisher: Guilford, Connecticut, The Lyons Press: 2001
Edition: First American Edition
Seller ID: 18724
Condition: Near Fine in Near Fine dust jacket
NEAR FINE/ NEAR FINE. . B&W and Color photographs. 4to 11" - 13" tall. 288 pp View more info
By: Huff, P.J.; J.G. Lewin (compiled by); Stuart A.P. Murray (ed)
Price: $40.00
Publisher: New York, Harper Collins: 2006
Edition: First Edition Thus. First Printing
Seller ID: 18502
Condition: As New in As New dust jacket
B&W Illustrations and Color Photographs. 4to 11" - 13" tall. xiii, 226 pp View more info
By: Sobol, Donald J.
Price: $13.00
Publisher: NY, Platt & Munk: 1960
Edition: First Edition. 1
Seller ID: 17680
Condition: Very Good+ in Very Good- dust jacket
Half bound in publisher's blue cloth over gray boards, gilt lettering on spine, pictorial endpapers. Illustrated in three colors (blue, black and white) by Jerry Robinson. . Head of spine has a tiny split in the blue fabric, head and heel of spine are lightly sun-faded, else pristine, unmarked, tight, square and clean. Unclipped dust jacket has short tears at the upper edge of the rear cover, the head of the spine and the upper tips and some of the lamination is separating from the jacket. VERY GOOD+/ VERY GOOD-. . B&W Illustrations. Small 4to 9" - 11" tall. 217 pp View more info
By: Swanberg, W. A.
Price: $35.00
Publisher: New York, Charles Scribner's Sons: 1957
Edition: First Edition Thus. First Printing
Inscription: Signed by Author
Seller ID: 20626
Condition: Very Good in Fair dust jacket
This first printing signed by the author. Very clean and tight. . Unclipped dust jacket is worn and chipped in spots. There is a slit on the front cover. Pages are faded but unmarked. . B&W Photographs. 8vo 8" - 9" tall. x, 373 pp. Signed by Author View more info
By: Ward, Geoffrey C. with Ric Burns and Ken Burns
Price: $40.00
Publisher: NY, Alfred A. Knopf: 1990
Edition: Fifth Printing
Seller ID: 20069
Condition: Fine in Fine dust jacket
Publisher's full black linen, copper lettering on spine, black and white illustrated endpapers with photograph of the 2nd Rhode Island infantry in the summer of 1861 on front endpapers, back shows survivors of the same infantry in 1886, introduction by Ken Burns and Ric Burns. . Volume is tight, square and clean. Unclipped dust jacket has very little shelf-wear. . B&W Photographs. xxi 426 pp View more info


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Venom wasn't a hit with critics, but don't tell the box office that. The movie set a record for October box office opening, but it hasn't stopped there. The film just crossed the $300 million mark overseas and is now staring down the barrel of a $500 million global take.
And make no mistake, it will hit that $500 million number. In fact, it's expected to go well past $600 million considering the film has yet to open in China, one of the largest box offices in the world. Venom doesn't even need to be a massive hit to put up solid numbers in China. Add to that the film hasn't opened in Japan yet either, and Venom still has a lot of fight left in it.
Venom won the box office each of its first two weekends in North America, and while it dropped to third last weekend, it still put up a solid $18 million.
According to Deadline, the great international numbers so far come thanks to both Korea and Russia, where the film has done just short of $30 million. In the UK and Mexico Venom has broken $20 million and in Brazil, the movie has done over $15 million.
Venom should be remembered the next time somebody worries about how a Rotten Tomatoes score is going to impact the box office. For the record, the film has a 30% positive rating, which is...bad. However, not only has Venom been successful in spite of that, it's thrived. A strong opening weekend is one thing. The character has a lot of fans who have been waiting for years to see him on the big screen, but the film has continued to make money every weekend. It didn't collapse after opening like many big tentpoles. The fact that it's been equally successful overseas is just as impressive.
For what it's worth, it seems like at least part of Venom's success comes from exactly the same thing that critics panned. The movie is somewhat...silly? However, it doesn't appear that even the movie's fans are denying that. Instead, they've chosen to embrace it.
As popular a character as Venom is among comic book fans, how the film was going to fair was still an open in question leading up to release. Venom has always been a part of the Spider-Man canon and without the ability to use the web-head to introduce the alien it wasn't a sure thing that people would accept the character. It is now.
While nothing official has been said about a Venom 2, you can bet with numbers like these that conversation is happening. It's also good news for the rest of the Spider-Man adjacent movies that Sony plans to make, including Morbius with Jared Leto which has been confirmed as the next one out of the gate.


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Beautiful Personalized Wedding Invitation Christmas Ornament
I have been getting a new Christmas tree ornament every year since my husband and I started spending Christmas's together. A new decoration to represent special traditions, milestones and inside jokes. One of my favourite ornaments is our Wedding Invitation Christmas Ornament because it's a way to display our invite in a creative and beautiful way.
If you're like me you likely have a ton of extra wedding invitations left over from the big day…better to have had extra then not enough, am I right? So, what's better then to bring one out every Christmas to admire and remember.
I also try to make these for each of my friends that get married. I keep the invitation, even if I receive it in the spring, and turn it into one of these special tree ornaments. They are always surprised when they see what's inside the glass ball.
Beautiful Personalized Wedding Invitation Christmas Ornament
What you'll need:
- Glass/Plastic Ornament Ball
- Wedding Invitation
- Ribbon
- Heart and key embellishment (optional)
- Pencil
- Scissors
- Ruler
The How To:
1. Take the wedding invitation and cut it into strips. Use the ruler and pencil to make straight and even strips. I know, it feels wrong to cut up the invite…but trust me, it'll be worth it! Cut some ribbon also, about 2-3 inch strips.
2. Wrap the strips of invitation around your pencil. Once completely wrapped, wait a few seconds to allow the curl to take hold before letting go. Repeat this process with all the strips and the ribbon.
3. Place the curled strips into the glass ball by removing the metal top. Add the curled ribbon strips every now and then to create some texture. Crafting tip: use the same colour theme that was used at the wedding!
4. Replace the metal lid. Add a ribbon loop to the top and attach the heart and key (optional) and it's finished!
If you loved this Christmas tree ornament idea take a look at this awesome DIY First Home Ornament, it's a wonderful idea that incorporates the key to your first home!
Disclosure: Some of the links in this post are affiliate links. There may be a small commission made by our recommendations, and/or link to products mentioned or services on this website. Any purchase you make will help us continue to bring you amazing content, step-by-steps and product reviews.


text: On 10/09/2012 13:49, Rushforth, Peter wrote: > But in general, the client needs a hint regarding what to negotiate for, and this > is what @rel and @type are for. In the context of the web in general and this thread in particular. that's wildly misleading. The overwhelming majority of links on the web have no such hints. The original question refered to referencing teh schema directly in the browser location bar (where there is no markup) or equivalently from a link such as in the archives of this list where it will be an html a link, again with no type information. > However, most 'properly configured web servers' would > provide an html representation and an xml representation, and not use the xml-stylesheet trick. That is a rather judgemental comment. You appear to be saying the w3c web server is not properly configured? In fact while serving different representations at the same URI and relying on content negotiation to send the right one has some uses in restricted circumstances, it also has many drawbacks, notably it makes it very hard to talk about the URL (or to be sure what you will get if you request it). Also I don't know why you should call using one of the more consistently implemented w3c recommendations "a hack". David -- google plus: https:/profiles.google.com/d.p.carlisle


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Stephen Joseph Knipper, 68, of Manchester, Iowa, passed away on Monday, April 9, 2018, at the Hospice House in Hiawatha. He was born on March 7, 1950, in Edgewood, the son of Raymond and Betty (Martens) Knipper.
Stephen graduated from Ed-Co High School in 1968. He was united in marriage to Susan Shea. Three children were born to this union. They resided in Manchester, where Stephen worked at United Building Center. The couple later divorced.
Stephen was an avid ice fisherman. He loved spending time with family, especially his children and granddaughter.
Survivors include Stephen's mother, Betty Knipper of Edgewood; his two sons, Stephen (Amy French) Knipper Jr. of Wadena and Shane (Kat Richman) Knipper of Marion; one granddaughter, Isabella Knipper; and three siblings, David (Ann) Knipper of Melcher, Marilyn Sundermeyer of Edgewood, and Dennis (Annette) Knipper of Edgewood.
Stephen was preceded in death by his father, Raymond Knipper, and his daughter, Sharon Knipper.
Online condolences may be sent to www.leonard-mullerfh.com.
Mass of Christian Burial: 10:30 a.m. on Monday, April 16, 2018, at St. Mark Catholic Church in Edgewood, with Reverend John Haugen officiating.
Visitation: 3:00 p.m. to 5:30 p.m. on Sunday, April 15, 2018, at Leonard-Muller Funeral Home in Edgewood. Friends may also call one hour before Mass at the church on Monday.
Inurnment at a Later Date: St. Mary Catholic Cemetery – Manchester, Iowa


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If your questions were not answered on our site, or you wish to book our container labour services then you can give us a call or fill out the enquiry form below. Our efficiency in container unpacking extends to our efficiency with contacting clients so you can be guaranteed you will hear from us quickly.
Phone: 0439 08 04 72
Email: email@example.com
Address: PO Box 964, Caringbah NSW 1495


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Kip Tiernan – USA
Linked with Rosie's place, and with Why are people homeless. Added Nov. 16, 2008: and linked with Poor People's United Fund PPUF.
She is one of the 1000 women proposed for the Nobel Peace Price 2005.
At a time when society believed that women's place was in the home, Kip Tiernan reached out to those women who had no home. In 1974, she founded Rosie's Place, the United States' first drop-in, emergency shelter for women. Kip has been at the center of the fight for economic and social justice for nearly three decades, advocating and lobbying for affordable and accessible housing, health care, education, jobs, civil rights, and peace. She currently serves as codirector of the Poor People's United Fund, which she founded … She says: "If we care enough to take the risk of being human, together we can change the world". (On 1000peacewomen).
Kip Tiernan is an American activist who may be best known as founder of Rosie's Place. She has been an advocate for economic and social justice for nearly three decades. Tiernan has protested and lobbied for affordable and accessible housing, health care and education as well as jobs, civil rights and peace. Drawing from her early roots in the radical Catholic left movement, Tiernan encourages people "to take the risk of being human" … // … Tiernan was also a founder of the Boston Food Bank (see the Greather Boston Food Bank) and co-founder of the Boston Women's Fund, Health Care for the Homeless and Community Works (see Police and Community Youth Club). In 1980 she co-founded the Poor People's United Fund, a "spare change" funding source for grass roots community groups involved in issues of homelessness, hunger and access to justice, and she currently serves as the co-director. In 1990 she established the Ethical Policy Institute, a multi-disciplinary community of people engaged in political analysis, economics and community activism. Tiernan also teaches as an adjunct professor at the University of Massachusetts. A popular public speaker and social commentator, Tiernan has lectured at hundreds of high schools, colleges, churches and conferences and written articles in local as well as national publications … (full text).
Kip Tiernan – USA (left)
She works for Rosie's Place, for the (Greather) Boston Food Bank, and for the Poor People's United Fund PPUF.
When has anything that Kip Tiernan and Fran Froelich done been conventional? Last night in a program sponsored by the Women's Resource Center and campus volunteer programs, the pair referred to as "the conscience of Boston" spoke about their outsider political theology in their book, Urban Meditations. (on BCHEIGHTS.com, a Bostons' students paper).
… Kip is a native of Connecticut who was orphaned as a child and raised by her grandmother. Always unorthodox, by the time she was 16 she was taking flying lessons and playing jazz piano … (full text).
She says also: (Alice) … "taught me patience, kindness, street smarts… I still miss her more than I can say."
One of the very first people I ever heard challenge homeless advocates to go beyond services to structural solutions was Kip Tiernan, a Boston activist out of the Catholic Worker mold. Kip is still around and at 77 continues to direct Boston's Poor People's United Fund with her longtime associate Fran Froelich … (full text).
Find her and her publications on ; on Google Book-search; on Google Scholar-search; on Google Group-search; on Google Blog-search.
Provides a $40,000 stipend and benefit package for one year to a woman, over 21 years of age, so that she can develop and carry out a special project that will further the mission of Rosie's Place anywhere in New England … (full text).
Rosie's Place Spring Gala: On 5/2, more than 200 guests gathered at the Channel 5 studios in Needham to mark the 80th birthday of social justice activist and Rosie's Place founder Kip Tiernan. The event featured cuisine from celebrity chefs and a live auction, raising more than $350,000 for Rosie's Place, a shelter for poor and homeless women. (Boston Magazine).
More than three decades after publication of the taboo-shattering book on female health, "Our Bodies, Ourselves," activists are still struggling to bring attention to women's health issues amid the national debate over medical insurance coverage, said one of the book's authors and feminist pioneer Judy Norsigian … // … The discussion was moderated by Kip Tiernan, co-founder of Community Works in Boston, an organization supported through Harvard's Community Gifts program (see box). (A scheduled participant, Byllye Avery, founder of the Black Women's Health Imperative, was not able to attend due to a family health matter) … (full text).
Kip created a sanctuary of love when she opened the doors to Rosie's Place 33 years ago and we continue to provide a community of support and hope for our most vulnerable sisters. With meals, groceries from our food pantry, advocacy services, emergency shelter, adult education, permanent housing, and more, Rosie's Place has created a critical set of services that help all women make real and lasting changes and reach for their dreams. The following examples highlight some of our achievements across the organization this past year: … (full text).
… The Kip Tiernan Social Justice Fellowship – Rosie's Place offers a stipend for a one year fellowship designed to provide support for an individual who seeks to create, design, or otherwise carry out an effort which will in some way further the broad mission of assisting and empowering poor and homeless women … (full text, October 31, 2006).
… Kip also used her writing skills to pen articles for the Catholic left, which appeared in the Boston Phoenix, Boston Globe and Boston After Dark. Through her parish, Kip came in contact with St. Philip's/Warwick House, which was involved in the civil rights and anti-war movements. In 1967, she was asked to help coordinate a press conference at St. Philip's and soon thereafter joined the team ministry because "poor people need advertising, too." Her work took her into housing projects, mental institutions, jails and hospitals where she saw first hand the effects of de-institutionalization and the lack of a coherent public policy to address the needs of poor and homeless people. In 1974, Kip founded Rosie's Place, the first drop-in and emergency shelter for women in the United States, in response to the increasing numbers of women throughout the country. Rosie's Place provided poor and homeless women with warmth, pots of piping hot coffee, nutritional meals, a safe place to rest from the dangerous streets, and perhaps most comforting – companionship. Kip's vision has helped Rosie's Place evolve from simply providing shelter to offering solutions: a drop-in center, extended stay housing, permanent housing, meals, and a multitude of on-site opportunities for our guests … (full text).
Native American shares her heritage;
the blog: Stone Soup Station (about homelessness);
the blog: Poet Jack Powers, Founder of the Stone Soup Poets;
the blog: Billionaires Perform To Raise Consciousness;
18th ANNUAL INTERFAITH MEMORIAL SERVICE FOR THE HOMELESS;
Trans Homelessness Article (Boston);
[Somerville MA] Radio with a View Live.