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When it comes to taking photos of a child there is a pretty standard process that is followed. A photographer can spend hours attempting to keep the kids happy while snapping traditionally posed photos. These parents wanted to accomplish something more memorable and they turned to their Adobe Photoshopping skills to get the job done. From scary life-threatening situations to silly photos that are beyond belief, these kids have been photoshopped with expert precision and the results are amazing.
A Babysitter And A Shark
When Hannes Sigrist and his wife, Erica were asked to babysit overnight for a friend they decided to go on an adventure with the small child. Instead of a regular walk around the park, they apparently took a perilous journey that included a Great White Puddle Shark. Other photos in this series include a T-Rex and other dangerous animals that could devour them in a second. We loved this photo the most because the baby appears to be looking right at the dangerous Great White Shark without a care in the world. This babysitter definitely went above and beyond.
A Daredevil Baby
When Matt Coyne's wife, Lyns, headed back to work after having their baby, Charlie, the proud papa decided to start sharing Facebook photos of their baby. His goal, at first, was to keep everyone, including his wife, updated on the daily adventures he was sharing with his son. After a lot of boring shopping and watching TV photos, this photoshop expert decided to have some fun with his kid. We're pretty sure babies are not supposed to go skydiving but Matt made an exception in this photo he shared of a recent adventure with Charlie.
An IT Director With A Sense Of Humor
Swiss IT Director John Wilhelm has gone viral on many occasions thanks to his ability to photoshop his adorable daughter into some really amazing works of fantasy. His quirky fairytale imagination has gone over really well with parents and art fans who love his ability to place his daughter in surreal circumstances. Her wide-eyed facial expressions definitely add a nice touch to every one of her dad's amazing photoshopped creations. Here it appears that she's taken on the abilities of a beaver, and is gnawing down a tree in the forest.
That's One Super Strong Baby
Andreas Miezans of Norway is a photoshopping expert and the dad to a young son. Miezans spends his days taking care of his little boy and that led to some fun with photoshop. He photoshops little Oscar into some pretty precarious situations. In one of our favorite, Oscar balances his dad on his feet and hands, playing off the classic "airplane" ride that usually has a little child riding on the hands and feet of their parents. His masterful work would have us questioning this baby's incredible strength if we didn't know it was photoshopped.
A Baby And A Balancing Act
If a child was photographed balancing on a toy like this in real life, Child Protective Services would be called and the child would be taken away. Thankfully, this was the work of photoshop expert Brandon Hill. This talented dad has mastered the art of placing his child in precarious situations with the help of his digital editing skills. Hill runs a popular Instagram account where fans of his work get to marvel daily at his baby's amazing, but fake, stunts. The final joke may be on dad, he could have a little climber on his hands in a few short years.
The Dangerous Antics Of A Baby
Social media has been inundated with pictures of babies ever since social networks first launched. Most of those photos are adorable but they also tend to be all the same. Dublin-based dad Stephen Crowley also wanted to show off his baby, but he wanted her to be placed in situations most baby photos would never dare to go. Hannah, his young daughter, has been photoshopped into various dangerous places, giving his Instagram followers panic attacks along the way. It's all fake but his work is impeccable.
The World's Best Father
Dave Engledow is known online as "The World's Best Father." He first went viral when he photoshopped his daughter getting her diaper changed with hilarious results. More images of his antics surfaced on social media and he was soon featured on Buzzfeed. His creations also led to a deal with Gotham Books. His dark comic sensibility has been compared to a modern-day Norman Rockwell. Be sure to check out his work in the book "Confessions of the World's Best Father" and you'll be laughing for hours.
Cheering Up Grandma One Photo At A Time
Jason Lee works as a professional photographer in the Bay Area and he has a knack for photoshop. He recently started placing his two daughters in some really funny situations in order to cheer up his sick mother. She was fighting cancer and wasn't able to spend any time with her germ-ridden grandchildren. Instead, Lee started to place his kids in some really crazy but creative situations. We grabbed one of his best photos which features his older daughter blasting her sister off with help from a rocket. What a great present for grandma!
This Dad Photoshopped His Incredibly Happy Baby
This Photoshop-savvy father realized his baby was super happy all the time, if only we could all be so lucky. He decided to show off their smile by photoshopping them into some amazing backgrounds. From Irish Dancing to flying like a superhero, this adorable little baby seems to be having the time of their life. Photoshopping skills are becoming more prevalent in the digital age and that means we get to see a lot more baby and small child photos like this one. We have to admit that this dad might be right, they really do have the happiest little bundle of joy on the planet.
The Perfect Head Of Hair
When this baby's photo hit the internet people couldn't believe they had already developed one of the most epic head's of hair they had ever seen. Immediately, photoshop experts jumped at the chance to place the young child's hair on the faces of actors who also sport a similar look. Whether you're a fan of Mark Wahlberg or Hugh Jackman, you'll love how perfectly this baby's set of hair fits on these celebrities. The original photoshop stories went viral and made this baby internet famous!
His Son Can Fly…
A Utah dad created some adorable photos of his "flying" kid to raise awareness about Down Syndrome. The young boy, soaring through the air, went viral and captured the attention of The Today Show which featured the dad's awesome work on the popular morning talk show. Alan Lawrence said the project is a way for him to prove to the world that even kids with Down syndrome, like his son William, can live lives full of wonder and "magic." The beautiful photos really are some of the best child-based photoshopping we have seen on the internet.
This Baby Is A Movie Star — Sort Of
Redditor baronvongrant started off with a single photo of his adorable baby daughter and then decided to up his parent-sharing game. He has placed his cute little daughter into scenes from Star Wars, The Matrix, Iron Man, Harry Potter, and many others. His daughter quickly became a favorite on Reddit and her photos now appear all over the social network, Imgur, Facebook, and various other websites. She's fighting the good fight and looking adorable at the same time — what more could we ask for.
Hanging On For A Photo Shoot
Emil Nystrom, an advertising and portrait photographer from Sweden, wanted to have some fun with her daughter, Singhild. Working in a creative job meant she already had the skills necessary to photoshop her daughter, she just had to figure out her angle. Like many photoshopping parents, she chose to place her child in danger. Her baby hangs from shelves, fixes car engines, and even holds onto a Samurai sword while hovering in mid-air. Sure most of the scenarios are impossibly ridiculous but some followers actually believe they are real.
Another Dangerous Baby Photoshop
Stephen Crowley made our list two times because his photoshopping skills are expert-level and he found a really inventive way to showcase his 18-month-old daughter on a daily basis. From driving the family car to precariously hanging from a banister, this little girl is an adventure seeker like no other. Crowley has made a name for himself because of his creative take on parenting and his ability to really scare new followers who don't realize, at first, that his daughter was photoshopped and not really risking her life.
Dad Photoshops His Daughters In The Best Way
Jason Lee made our list twice because he didn't want to share the same type of tired posts that other parents were showing off on Facebook. Rather than posting his daughters against a set of trees in the fall or having them stand still for any other type of professional photo shoot, he decided to have some fun. In this photo, his daughters are drinking straight from a Krups espresso machine. He started taking photos of his daughters back in 2006 and has gone viral many times because of his amazing work.
A Dangerous Situation
John Wilhelm appears a few times on our list because his daughters are constantly placed in very dangerous, but digital, situations. With his kids in tow, he takes photos and places them up against some scary odds. This time, he placed his daughter between some very hungry looking Alligators. Not only is John a master of Photoshop, he also takes some brilliant photos that really highlight his eye as a photographer. His daughter definitely adds to each of his photos by providing the perfect look on her face for every photo.
A Dad Brings His Kids' Fantasies To Life
John Wilhelm is one of our all time favorites, which explains why he made our list not once or twice but three times. Not only does he place his children in precarious situations, he also takes their quirky fantasies and brings them to live. Just look at his adorable three children as they take a bath and are visited by a pelican. His photos have been viewed hundreds of millions of times and have been covered by mainstream media. We're not sure how his children feel about his work but they seem to be having a ton of fun in this photo.
A Practical Joke On Mom
This dad loves to play practical jokes on his wife and this joke went way too far. The day before family photos were scheduled to be taken, this dad sent his wife a text message and said there was a haircut accident at home. He was attempting to trim his son's hair when he accidentally took a little too much off the top. His further attempts to fix his mistake led to more hair being cut. Feeling bad about the situation he continued to cut his own hair for a matching look. Fortunately, it was all a photoshop joke that went too far.
Father Son Face Swap
Most face swaps are downright creepy, but this one lands more on the creative and funny side. This father decided to take a photo of himself holding up his son, face swap the two of them, and the result is amazing. There's no doubt that later in life when his son is old enough to appreciate the humor, he'll love having this hilarious photo of himself as a baby holding up his father. We wished half the auto face swaps from phone apps turned out this impressive!
15 On 11
Gone are the days of having to get out and pump the gas for the car if you're an adult. Babies are now willing and able to get up and do it on their own. Just look at this little fella'. He is up and at em' even posing slightly for the photo opportunity. Andreas Miezans Photoshopped this one quite well if we don't say so ourselves. He has made the list earlier on but he returns to a classic baby pump action. Imagine if this were real, parents would love if they could ask their baby to pump the gas.
Time For A Magic Show
This dad is already plenty cool, now he takes it to the next level. When this baby grows up, he is going to thank his dad for making his young life seem so fun. Even if it is photoshopped, just looking back at pictures like this can warm your heart because it shows that you had a father who really wanted to make your life great. The photoshop is so real that it looks like the baby is really enjoying the magic show! What did he tell his baby to focus on while the picture was taken?
There Goes Your Finger!
Sometimes the parents kid around and take the nose from their kid. The kid starts busting into laughter as the parent uses his thumb as the fake nose. Well, this time, the tables have turned and the kid seems to have chopped off the parent's thumb. The Photoshop job on this one is amazing. If you look at the plate, you see the bloodied finger and the baby is holding the instrument of destruction in both of his hands. And the face of the dad is priceless. It perfectly fits this "what if" situation that's going on.
Make Sure You Go Head First
That's how you're supposed to do it. When your friends are doing something dumb, you cheer them on with a beer in your hand. Only this time, the friend is your baby and the thing that's stupid can kill him. Another great Photoshop job here as we are witnessing a baby about to crush its skull in the small pool. The baby almost looks like he is in a scene for a spy movie as he rappels down the side of the fence. The way the dad is cheering is almost too realistic. You would think he wants his baby to really try this.
Pitch In, Will Ya'?
Would you let your kid help you with the cookout? Maybe once they become a teenager but not when they are young and ripe. That's what makes this one so good. To see a child who probably can't walk yet sitting on a wooden railing with a hot dog on his fork is priceless. Not to mention the fact that there is a fierce fire below his feet but it is no big deal for this supreme baby who can handle anything. This Andreas guy really is creative when it comes to things like this.
Rooftop Ride Looks Too Real At First Glance
This one looks so good it is like he is really on top of the roof enjoying the ride. His little feet are dangling in the air to put the cherry on top. "I wanted to try something different to put a smile on Oscar's face when he looks back at them," Andreas said. Well, he will certainly have a smile on his face once he's old enough to realize how cool these pictures are. This is certainly a great time capsule gift that Andreas has going on for Oscar.
Up Up and Away!
A trip to the park with your son should cost you little to nothing. Feeding your son while at the park shouldn't cost you that much either. Launching your son into the air while on a see-saw, priceless. Not like any parent should let this happen, but if one did and they had someone prepared to catch the baby? Do you think the baby would be laughing while in the air or would they become smart and realize that their life is in danger? Whatever you conclude from that question shouldn't make you go out and want to try it.
It's Time For The Kid To Earn His Stay
Once again, the kid is doing the work that someone older should be doing and Andreas loves it. If only this were real. If only young kids were able to do chores like this. It would make life that much more enjoyable but you would also have to worry more about their safety. That means you would have to teach them that much better to avoid mistakes and injuries. Nevertheless, this one could pass as not a Photoshop image at all. Just a well-timed photograph. Would you have the courage to let your young child stand next to a lawnmower like this for a picture?
Zombie Walker Baby Thing…
Perhaps this young child is a fan of Walking Dead? That would have to be the only logical explanation as to why a child is recreated as a bloodied up human. Or perhaps the parent is too much into the show and wanted to take out the fanboy in them on the child. Whatever the case, either this child is going to love this image or hate it in the future. Revealing this photo to the child would be a hard case for anyone because you do not know the expectation you are going to receive.
Rockstar Baby In The Flesh
This baby is ready for the show! The crowd is in for a treat when this baby comes on stage, tongue out equipped with the glasses to match the paint on the face. How much cooler would this be if the kid grew up and was really into the band? That would make this Photoshop one of the best of all time. We're not too sure if the mother approved of this image or if the father asked for permission but it just makes it that much better of an image to look at.
Today, We fight!
Oh you know, just a regular photograph of a clip from a movie. Nothing to see here, except that baby with a spear and shield in his hand! The child even looks like the leader of the pack by his placement in the field. He has the battle cry down as well to follow suit of everyone else who is about to risk their lives. Even the black and white adds a bit of dramatic touch to the picture. This baby will for sure love this when he or she is grown up and gets to appreciate it.
You're A Wizard, Baby
The power now within you comes with great responsibility, baby. This is an awesome picture. The child looks enamored and the background matches the scene perfectly. A long staff and wizard hat looks to be the perfect combination for a baby Photoshop. It looks like the baby was meant for this moment and is just taking it all in. Most likely the child is looking up to the photographer who is holding up something that interests the child. Parents, we give you full permission to recreate a photoshoot with your child like this one so get started!
Just Showing Them Around The Farm
the love a baby has for an alpaca is unmatched. The two were made for each other and it couldn't be more clear to see. The alpaca looks to be protective of the young one too so if things look like they could be going south, chances are the alpaca will do whatever in its power to ensure the safety of this precious child. On a serious note, this is a good Photoshop and probably one of the better ones on this list. Always remember that animals mixed with a baby are always an adorable sight to look at.
All Aboard The Baby Train
Thomas the Train never looked so cool! He also never looked so childish. This is one of the cutest Photoshop jobs on the list. It even is done pretty well so bonus points for that. If you show the child this photograph then show the real image, chances are the baby might get confused. Or perhaps he or she won't notice but it would still be fun to check for a reaction. We can't tell if this particular baby in the image is screaming or yawning. Any guesses out there from anyone.
"I'm Going To Need Everyone To Put Their Bottles In The Air!"
DJ Baby Boo on the Ones and Twos! All the babies need to get up out their seats and make the dance floor come alive! The bar closes at 11 so you have to be sure to get your fix on that formula milk! That might be something that a DJ baby would say if they could really talk. Check the detail on the Photoshop. You can see the tattoo that the baby has on the left forearm and you can also see the intense crowd in the background. You go, baby.
The Baby That Ate Everything
You're in the delivery room and the baby is about to come out. You are as excited as you ever been but also nervous at the same time. The moment has arrived and your new child is coming out. You see the hair and out of nowhere his mouth looks like something from a sci-fi film! You panic at first but then you start to embrace it. Your new little man is capable of out eating the family dog so now, you have no more leftovers. This is what he looks like at eight months.
The Baby Beard Looks Nice
Sure, many of us have seen The Curious Case Of Benjamin Buttons but we have not seen it in real life. Had this been a real picture then we would have all been able to experience the coolness of this baby beard. Others might have been a little concerned if they saw this in real life while others would be all for it. The possibility to have your newborn son to grow a beard is a something some men might really want. But what do we know? Matching beards with your young son could be a great thing.
Houston.. We Have A Problem
Sending your baby to space is something you probably don't ever want to do. Even if they paid you to do so, you shouldn't even consider it. That doesn't mean you can't Photoshop them into the great mystery that is space. They'll look back at it and show their friends that they were a baby, they were in orbit just relaxing like a boss. However, the only flaw is that she may have a helmet, she does not have a suit so her body wouldn't survive. No problem, just get back on Photoshop!
If Unicorns Were Real…
This just might be every young girl's wildest fantasy. To ride on a unicorn in a pink sky and the unicorn happens to be pink as well. What young girl do you know that doesn't like pink or unicorns. It's rare that you get one of those but hardly ever do you come across a young girl who doesn't like both! When she grows up and look back at this, her day will be made and it will probably be posted on social media as a throwback Thursday picture and for good reason.
One For The Books
Earlier, we showcased a baby strapped up to his father as they sky dived. Now we have a sole baby boy falling through the sky with his little parachute and goggles. An adorable sight but also one that would give the grandmother a slight heart attack because she may jump to the conclusion that this indeed real and not Photoshopped. The baby looks like she is really enjoying the experience too. The real photograph is probably the baby on her belly laying on the bed. Good job with editing this one, whoever did it.
A Child And A Coyote
It's not just dad's who are dominating the child and baby photoshop space. This mom played a prank on her husband by bringing a coyote into their home. After photoshopping the animal next to her child, she sent a text message to her husband to show off the "stray dog" they found outside. As expected, her husband freaked out and warned his wife that she had found a "wild animal" and needed to remove it immediately. His wife continues to insist it was a scared and lonely dog that needed a good family to watch after it.


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Finding Romance in Work: 3 Ways to Engage Employees
There's a honeymoon stage to every good thing, including a job. You've been a new hire before at some point, so you get it. When you start that job, you're excited and ready to embed yourself in your work and new company. The honeymoon stage ends, inevitably, but that doesn't mean work can't be engaging long after the romance fades. Like every strong relationship, it's about an evolving enjoyment and appreciation for where you are and who you're with.
We're strong believers in making the office a place employees love to walk into every day. For management, that means finding ways to engage your employees by bringing them together and supporting an all-around awesome culture. Your employees will thank you for it, enjoy coming to work more and have a stronger sense of camaraderie and belonging, which in the long run can mean more fulfilled employees and less turnover. Here are a few suggestions to get you started.
Whether this looks like a steps challenge with a gift-card reward for the teammate with the most steps or a plane ticket for the person who closes the most sales by the end of the year, you can always inspire your team with incentives that support their interests outside of work. If you do a culture survey at any point in the year, ask employees what reward they'd enjoy most so you can get a better idea of what will give them a motivation boost.
Dale Carnegie wasn't wrong when he wrote, "The deepest craving of all mankind is a desire for recognition and the feeling of importance." Everyone loves when their hard work is acknowledged and appreciated. It doesn't cost anything to engage your employees this way, but you have to first set goals — both long term ones and short term ones that employees can work toward each week. Set a time during the week for a quick team huddle where you can each recognize something outstanding another teammate did — from supporting a different division to getting great feedback from a client or customer.
The little things add up, and company perks are your chance to show your team that you're thinking about them. It's not all ping pong tables and a stocked snack cabinet either (though those are great perks). It could be paid metro passes for all employees or a zen room where employees can hit pause and practice mindfulness throughout the day. The best perks, though, are the ones that bring the team together. What better way to do that than with lunches? Every employee loves free, corporate lunches. And with Sifted, all members of the team are included — from the vegan to the gluten-free eater. We craft healthy meals with fresh, clean ingredients that fuel your team. You just tell us how everyone eats, how often you want lunches, and you're good to go. Your employees get the chance to connect over a good meal while you get the chance to live out your commitment to a fun and inclusive office culture.
We get that Fridays will always be better than Mondays, but that doesn't mean work has to be mundane. By engaging your employees in a way that supports your core values and culture, you can start building a more inspiring and creative workplace today. How do you engage your employees? Let us know in the comments!

subset: commoncrawl


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Cure Arthritis Naturally
It is well known that OA differs in men and women. Men younger than 50 tend to be most affected by OA, whereas, in people over 50, two thirds of the OA patients tend to be women [69]. The reason for this is unclear. Osteoarthritis in younger men is considered to be an occupational disease. In contrast, the high incidence in postmenopausal women suggests that the change in hormonal status may play a role in the OA process. However studies dealing with the protective effect of estrogens show conflicting results (reviewed in [67,95,203]). A study in cynomolgus monkeys has shown that long-term estrogen replacement therapy significantly reduces the severity of OA lesions [94]. These data conflict with a common notion that, as noted for many years, there is an inverse relationship between OA and osteoporosis [191]. However, considering the prevalence and characteristics of the two diseases, it would not be surprising if they coexisted on occasion [6]. Moreover, some patients present with nonprogressive OA, whereas others with progressive OA also have increased bone resorption [13]. Conceivably the latter category of patients respond to estrogen therapy. Interestingly, a recent study suggests that antagonists of cannabinnoid receptors can protect against bone resorption [110]. Magnetic resonance imaging can help obtain a more precise estimate of the effects of estrogens on cartilage and bone. Estrogens may prevent some metabolic changes in subchondral bone osteoblasts and in chondrocytes, thereby causing a slowdown in the onset of OA. The efficacy of estrogen therapy may also be due to genetic susceptibility. Indeed, the estrogen a-receptor gene (ESR1) has been identified as a candidate gene that may be involved in OA (reviewed in [137,177]).
Genetic studies have pointed to a recessively inherited gene. Because the cause of OA is likely multifactorial, the "gene" more probably expresses a factor involved in a metabolic pathway rather than a structural protein. Some studies examining a metabolic link between obesity and OA have reported a significant association between hypertension, uric acid, cholesterol, and OA, whereas others failed to substantiate these relationships [48,146,220,225]. A unifying hypothesis could be that OA is a metabolic disease in which systemic or local factors induce changes in skeletal tissues. As tissue homeostasis is disturbed and joint integrity impaired, normal wear and tear could lead to cartilage damage, the hallmark of OA. The loss of cartilage may then be the result of mechanical forces, but this would not be the cause of the disease itself. Furthermore, the OA process may modify the formation and biosynthetic activity of cells derived from mesenchymal stem cells (MSCs) [5]. Osteoblasts derived from mesenchymal precursor cells can also give rise to chondrocytes, myoblasts, adipocytes, and tendon cells [97], all cells affected by OA. However, when bone marrow MSCs from OA patients were cultured, they did not exhibit altered in vitro proliferation, nor did the number of osteogenic precursors change with age [174]. This contrasts with observations on osteoporotic patients. Nonetheless, the osteogenic activity of MSCs of patients with advanced OA is enhanced, whereas their chondrogenic and adipogenic activity is reduced [168]. Because adipocytes share a common mesenchymal stem cell precursor with osteoblasts, chondrocytes, tenocytes, and myoblasts, a link may exist between lipid and connective tissue metabolism in OA [5]. The link may be leptin, a systemic factor that plays a role in body weight regulation, lipid metabolism, and obesity. Indeed leptin may be a key factor in the etiology of OA [60,124,138].
The potential role of bone tissue in OA initiation or progression may also be due to its capacity to serve as a reservoir for MSCs and to provide nutrition for the hyaline cartilage. The role of mesenchymal cells in the appearance or progression of OA is a key issue that has received recent attention. Because there is increasing evidence of the abnormal behavior and phenotypic features of osteoblasts, chondrocytes, myoblasts, and tenocytes in OA joints, MSC development and differentiation are likely to be altered in affected individuals. Evidence indicates that MSC numbers, proliferation rate, population-doubling time and the capacity to differentiate into different lineage cells may be altered in OA [58,168,169]. The response to cytokines and growth factors by MSCs in OA individuals may also be altered [135]. This may indicate that their differentiation into target cells is also altered in vivo, leading to abnormal tissue homeostasis [140,211]. It also suggests that cells not presently residing in the affected tissue may profoundly affect behavior and homeostasis of this tissue. The number of MSCs characterized by in vitro multilineage potential is larger in OA than in rheumatoid arthritis synovial fluid [114]. This indicates that, although related, these two diseases have diverging etiology and progression. Moreover, because the chondrogenic and adipogenic capacity of OA MSCs is impaired [168], OA MSCs either remain undifferentiated or differentiate into limited lineage cells, such as the osteogenic line. This can explain why all joint tissues except bone are impaired or reduced in OA individuals. Indeed, although muscle strength is reduced beyond the normal age-related loss [108], possibly due to muscle cell dysfunction [107], alterations in the differentiation capacity of MSCs to form myocytes may also be altered in these individuals.
Even more importantly, this alteration in MSCs may also affect the important immunore-gulatory role played by MSCs in OA tissues [55,119,121]. This regulatory role is modulated by the action of specific signaling molecules such as TGF-P and HGF. In this connection it is important to remember the key role played by cytokines and growth factors in osteophyte formation, and the elevation of TGF-P [149] and HGF levels in OA cartilage, although the role of HGF is uncertain. Osteophyte formation maybe considered a repair response to stabilize the damaged joints. It requires the local recruitment of specific MSCs. This demonstrates the potential therapeutic role stem cells may play in OA joints.
Recent genome-wide scans have revealed an OA susceptibility locus on chromosome 11q, in close proximity to the low-density lipoprotein receptor-related protein 5 (LRP5). This gene product controls bone mass and may be the cause of the abnormal bone tissue mineralization and remodeling observed in OA patients. Although no individual polymorphisms were found in a study of 187 individuals, an altered haplotype of LRP5 was identified that increases the risk of OA 1.6 fold [222]. Therefore, LRP5 and the associated Wnt signaling pathway may constitute significant factors in the pathology of OA.
Felson et al. [68] have provided an interesting new perspective on subchondral bone marrow changes in OA. They found a strong correlation between the marrow edema and pain, but not with the severity of pain. In a longitudinal study, they also found that bone marrow edema was largely related to limb alignment [214,219]. Medial bone marrow lesions were seen mainly in patients with varus limbs, and lateral lesions were seen mostly in patients with valgus limbs. However, even after adjustment for misalignment, bone marrow edema lesions were still strongly associated with radiographic progression.
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When you hear the word arthritis, images of painful hands and joints comes into play. Few people fully understand arthritis and this guide is dedicated to anyone suffering with this chronic condition and wants relief now.


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Matt Smith's Jan. 7 column, "Artist Con," stated that art dealer Nancy Wandlass pleaded guilty to felony embezzlement charges. In fact, Wandlass pleaded guilty only to a single felony embezzlement charge.
The column stated that in February 2007, her condominium was "heading irreversibly toward bankruptcy sale." In fact, it was headed toward a trustee sale.
The column also referred to Wandlass' "$30,000 Escada wardrobe." While a bankruptcy trustee's report shows her spending more than $30,000 on clothing between April and August 2007, only $18,415 of that money was shown to be spent at Escada. The balance was at Saks Fifth Avenue, Louis Vuitton, and Foot Candy. SF Weekly regrets the errors.
February 2007 was a tough month for Nancy Wandlass, an international art dealer known for her Louis Vuitton handbags, $30,000 Escada wardrobe, and constant presence at the Marina District's tony Rose Cafe. Two months earlier she'd been arrested with her husband, Thomas, on charges of fraud, grand theft, and conspiracy for allegedly stealing two 19th-century French paintings valued at $300,000. Adding further stress, Wandlass was attempting to crawl out from under millions of dollars' worth of past-due bills in bankruptcy court. The Wandlasses had run Pacific Heights Gallery from a condominium they owned on Jackson Street, but it was now buried in liens and heading irreversibly toward bankruptcy sale.
Perhaps worst of all, her long-held reputation as the stylish rogue of the tight-knit, handshake-based S.F. art world was wearing parchment-thin. More and more dealers had come to view her as a cheat. "None of us would ever deal with her. We knew she was a gonif — that's Yiddish for thief," said Ed Russell, who for 35 years ran the Graystone gallery on Geary Boulevard downtown, and now sells paintings by appointment.
But Wandlass had escaped tight spots before, and as she awaited trial for allegedly stealing the 19th-century French artworks, she told a bankruptcy judge that she was about to hit a home run that would make things right again. "With the additional paintings I am negotiating on to have for resale, the commissions from those paintings will pay off the remaining balance due to the secured creditors and also payoff the unsecured creditors," she wrote.
A Los Angeles lawsuit and a New York federal forfeiture case suggest that Wandlass really did bat one over the fence. In early 2007 she was serving as middleman for the sale of two modern paintings — "Hannibal" by Jean-Michel Basquiat, valued at $8 million, and "Modern Painting with Yellow Interweave" by Roy Lichtenstein, appraised at $3.5 million.
But, as seems to sometimes be the case with the Wandlasses, their business dealings were accompanied by a troubling backstory: The Basquiat and Lichtenstein paintings were contraband. They'd been smuggled into the U.S. with the help of falsified Customs documents after disappearing from the collection of a Brazilian banker convicted of fraud. The U.S. is now seeking to repatriate the paintings on behalf of the Brazilian government.
The Wandlasses' attorney, Cris Armenta, said her clients were innocent victims. "The Wandlasses are in full compliance with the law," she said. "They have cooperated in every respect with law enforcement to the extent that they've been requested." Indeed, court papers regarding the smuggled artworks appear to contain no evidence that the Wandlasses were aware of the paintings' troubled provenance.
In September, Nancy Wandlass cut a deal with prosecutors in which she pleaded guilty to felony embezzlement charges in connection with her 2006 arrest, Deputy District Attorney Bob Ring said. She was given three years' probation. Thomas Wandlass pleaded to a misdemeanor accessory charge, Ring said.
Despite their convictions, and the legal drama over the Basquiat and Lichtenstein pieces, the Wandlasses appear to be staying in the art business. When I reached Thomas Wandlass by phone recently, he said the couple's apartment-based gallery business continues "by appointment."
Edemar Cid Ferreira, the former head of Brazil's Banco Santos, made a name for himself in the art world by amassing a trove of famous Modernist paintings, which were displayed at international exhibitions he sponsored at museums such as the Guggenheim. After the bank failed in 2005, he was sentenced to 21 years in prison for perpetuating a $1 billion fraud, according to a U.S. government forfeiture case filed in New York. When Brazilian officials sought to reclaim some of his ill-gotten gains, they discovered that items worth some $30 million from his art collection were missing. Among them were Basquiat's "Hannibal" and Lichtenstein's "Modern Painting with Yellow Interweave."
As it turned out, the Lichtenstein painting had been crated and sent to New York from the Netherlands via a Panamanian shell company in December 2006. It was accompanied by paperwork describing its contents as "ornaments" worth less than $100, according to the federal forfeiture case. The crate's recipient, a New York art dealer named Alberto Barral, seemed to know what was inside. After the shipment arrived, Barral called the warehouse asking for "the Lichtenstein," the forfeiture filings say. He was told there was no record of anything under that name. According to the filings, he instructed the warehouse to uncrate the falsely identified 2006 shipment. Barral did not respond to a faxed request from SF Weekly seeking comment.
Wandlass made a deal with Barral to sell the Lichtenstein and the Basquiat, which arrived in New York several months later. In turn, according to a January 2007 consignment agreement, they agreed to have Doug Chrismas, owner of ACE Gallery in Los Angeles, sell the Lichtenstein. Chrismas sold it for $1.3 million to L.A.-area collector Seth Landsberg, who appraised it at $3.5 million for resale at Sotheby's.
ACE Gallery then ran the painting's name through a database of stolen artworks. Days later, a federal agent contacted the gallery to warn Chrismas that the Lichtenstein was subject to seizure and forfeiture, court papers say. In November 2007, federal agents seized the Basquiat painting from its New York warehouse. Armenta said the Wandlasses had no idea about the paintings' clouded origin. "They were absolutely stunned and surprised when they learned of the New York seizure action, and when they learned of the conditions concerning the paintings," the attorney said. "Pacific Heights Gallery had absolutely no knowledge of the conditions under which 'Hannibal' or 'Modern Painting with Yellow Interweave' were transported or brought to the United States. ... Pacific Heights Gallery entered into certain consignment agreements with a reputable art dealer in New York, Al Barral, with whom they had previously conducted business."


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Ph.D. Application Deadline:
January 15, 2020
M.S. Application Deadline:
April 1, 2020
How to Apply to Ph.D. or M.S. programs in Biomedical Research at SUNY Upstate Medical University
If you are interested in Upstate's Clinical Programs (Nursing, Physician Assistant, Public Health, Clinical Perfusion, Medical Technology, Behavior Analysis), please email email@example.com.
In these pages, you will find the guidelines on How to Apply for the College of Graduate Studies Ph.D. and M.S. programs. If you have any questions, please feel free to contact us at email@example.com. Inquiries about Upstate's Clinical Programs may be directed to email@example.com.
Accepted students to the Ph.D. Program enter through a general umbrella Biomedical Science program where they have great flexibility in charting their future. Their first year at Upstate includes core classes and three lab rotations, of the student's choosing, where they are exposed to a variety of research projects. The student then selects a mentor and becomes affiliated with a degree-granting program at the end of their first year. These degree-granting programs include Biochemistry & Molecular Biology, Cell & Developmental Biology, Microbiology & Immunology, Neuroscience, Pharmacology, and Physiology.
Four programs in the College of Graduate Studies at Upstate Medical University offer M.S. degrees. Students enter these programs directly : Biochemistry & Molecular Biology, Cell & Developmental Biology, and Pharmacology.
When the SUNY Upstate Medical University's Office of Admissions receives a completed application, our staff begins a comprehensive, holistic review. This is done without regard to sex, sexual orientation, race, color, creed, age, national origin, disability, veteran status or marital status. In a holistic review process, we consider the applicant as a whole individual rather than select parts, such as GPA or test scores. In doing so, we evaluate applicants based on who will contribute to the SUNY Upstate Medical University's academic community in meaningful ways. Holistic review takes into account factors such as a student's strength of coursework, research experience, academic and extracurricular interests, background, and personality. By evaluating an application from a holistic perspective, we take the time to get to know applicants as people, not as numbers.
See our Frequently Asked Questions regarding Admissions, Stipends, etc.


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A cloud of witnesses: Opportunities for ecumenical commemorationMonastery of Bose, Italy
[auf Deutsch, en français, en inglès]
Men and women who, throughout the history of the church, have set examples of Christian life have left a rich heritage to the ecumenical community. An international symposium at the monastery of Bose, Italy will explore the meaningful content which the joint remembrance of these witnesses to the faith can give to ecumenical worship.
The discussions on how to receive the gifts embedded in the history of other Christian denominations will be informed by Orthodox, Roman Catholic, Pentecostal as well as other Protestant perspectives.
The list of speakers includes Dr Mary Tanner, WCC president from Europe.
A commemoration of Christian witnesses will take place on Saturday, 1 November, the day that in the tradition of Western Christianity is celebrated as Feast of All Saints.
The symposium is co-organized by the World Council of Churches Commission on Faith and Order and the monastery of Bose.
To get the message of the consultation, click here.
More information on the website of the Monastery of Bose


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|Select the Course Number to get further detail on the course. Select the desired Schedule Type to find available classes for the course.
|UNXD 350 - Life Negotiations
Negotiation affects all of our lives. We constantly strive in so many daily situations to secure agreements or cooperation or coordinated conduct with others that benefit our own interests. This course introduces students to the structural theories and the practical applications of negotiation, and, with a series of realistic simulations, explores the behavior of individuals and organizations in competing situations. Through a series of negotiation exercises, lectures, videos and class discussions, students will come to understand negotiation theory, and will practice negotiation skills that will be useful for a lifetime. Simulation exercises employ hypothetical situations in which students agree on the various terms of a new job, negotiate the terms of an apartment lease, and buy/sell a house, among others. Simulations give students an opportunity to develop and try their negotiating skills in a safe environment with continuing feedback from the professor and their classmates.
1.000 Credit hours
1.000 Lecture hours
Levels: MN or MC Graduate, Undergraduate
Schedule Types: Seminar
Univ Wide cross disc courses Department


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Ato learns to read
His teacher writes on the blackboard: on. Say after me: 'oooh - enn - on!'.
All the children say it, and they say it again and again.
Next, the teacher writes: no. Say after me: 'enn - oooh - no!'. The children repeat it and repeat it again.
For homework, they have to write the words 'on' and 'no' ten times each.
Ato's father looks in and points at 'on': 'What is this word?' Ato shakes his head and says: 'Me nim...' and continues copying.
He feels bored and doesn't understand why he has to write those words.
Ivy learns to read
Her teacher writes 'd' on the blackboard. All the children repeat the sound 'duh'. The teacher writes a large 'd', and the children imitate the motion of writing 'd' with their hands in the air. Then they trace the same letter in their books. What is the sound? 'Duh!'.
They mention words that start with sound 'duh': dabo-dabo, dua...
When Ivy takes her bath in the evening she says to herself: 'dware' begins with 'duh'.
The next day, Ivy learns sound 'ah' in a similar way, and by the end of the day she can read the word 'da'.
That evening, when her mother tells her to go and sleep, Ivy feels happy: 'Mom, 'da' is 'duh' and 'ah', and I can read it!'
FonixGH gives every Child the 'Ivy experience'!
"I never could remember the letters. With the FonixGH book I learned the letter sounds, and now I know them! I can now already read short words."
Robert (8)
"Before, I would write the alphabet on the blackboard and make the children recite. The FonixGH method teaches letters one by one, and establishes each letter thoroughly through a variety of activities. My children now enjoy my reading lessons!"
Joyce, teacher
"My elder daughter took a long time before she could read well, though she generally learns faster than her sister. My younger daughter learned reading with FonixGH and I can see that her reading is much more advanced"
Peter, father
"Fonix is my favorite book: I like tracing the letters with my fingers and enjoy hearing the sounds of the words. And the words are easy because it is Twi!"
Esi (5)


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The last fifteen years have been majorly kind on the twins from Sweet Valley High. In fact, they almost give the Saved By The Bell cast a run for their money.
Brittany Daniel and twin sister Cynthia Daniel, who played Liz and Jessica Wakefield, were eighteen when the show started airing in 1994.
They're now nearly 40 and Cynthia has three children. But they don't look like they have aged at ALL. Seriously, look at them…
Brittany has carried on acting since her Sweet Valley days and has had starring roles in US comedy shows The Game and It's Always Sunny in Philadelphia.
Last year, Brittany revealed that she had been battling cancer, telling People: "My family is everything to me and I feel like they saw me through this." Luckily, she is now cancer-free.
Her sister Cynthia quit acting after Sweet Valley High and became a photographer instead, as well as marrying and starting a family.
While their amazing Benjamin Button ageing is incredible, we're still slightly more in awe of Bruce Bogtrotter from Matilda's transformation. Don't even get us started on Zac from Hanson…
Follow Claire on Twitter.


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PX7 FM Synthesizer
Six Operator FM Synth
- • A faithful recreation of the legendary 80s synth
- • Huge sound library with original and custom sounds
- • Powerful FM synth, yet easy to use
The PX7 FM Synthesizer is a six operator FM synth for the Reason rack. As a faithful recreation of the popular DX series keyboards, it provides a wealth of new sounds, ranging from classic 80's bass and brass to modern textures, leads and growls.
The PX7 FM Synthesizer is a six operator FM synth for the Reason rack. As a faithful recreation of the popular DX series keyboards, it provides a wealth of new sounds, ranging from classic 80's bass and brass to modern textures, leads and growls.
But PX7 is not only an emulation of a classic keyboard. With an easier interface, macro controls for quick and powerful tweaking of sounds, stereo spread, and full integration with the Reason rack, it takes FM synthesis into the age of Reason.
In FM synthesis, or Frequency Modulation, sounds are generated by layering or modulating the frequency of sine wave oscillators, called operators. The 32 selectable algorithms decide how the operators are connected, and which modulates what.
The envelopes, one for each operator, are more advanced than those you typically see in synths, with a number of different breakpoints for extremely precise control over the modulation.
With the new macro controls you get tons of new tones out of a single patch — even without a full understanding of FM synthesis.
PX7 includes a great set of new patches and Combinators with sounds ranging from modern to futuristic. But perhaps best of all: the PX7 FM Synthesizer is patch-compatible with the classic it's based on—and faithfully reproduces its trademark tone. A ton of patches from the original is included with PX7. A free ReFill containing over 168 000 additional patches — said to be the complete collection of all sounds ever made for the DX series synths — is available as a free download, too.
If the 100 000+ included sounds aren't enough, our online patch converter takes Yamaha DX7 patches and converts them to PX7 format, giving you immediate access to all thinkable sounds available for the best-selling original.
PX7 FM Synthesizer. A six operator frequency modulation digital synthesizer for Reason.
All product names used are trademarks of their respective owners, and in no way constitutes an association or affiliation with Reason Studios. All trademarks are solely used to identify the products whose sound was studied during the development of PX7 FM Synthesizer.
VersionReleased: 2013-05-30
DeveloperReason Studios


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Among the various kinds of the golf laser rangefinder, one common kind is of the Callaway range finders of golf. This brand is used very commonly in the range finding practices in golf. Usually in the latest modes of range finders of golf, there are external applications of the LCD and new attachments. This twist in technology has brought a new revolution in the field of range finding. The application of laser technology in the golf range finding is the first and unique application of its kind which has never presented before. The IDTECH range finder in golf has com up with an external LCD and this has brought a new twist to the latest laser technology.
In order to fully enjoy the game of golf and to increase the pace of the game, you need to arm yourself with the latest models of the golf laser range finder. This can be of great advantages in the field of range finding of golf. There are many different popular brands presently producing their products with latest applications. Among these Nikon is the very popular and reliable brand. You can have the original digital processing system of Nikon in the latest produced laser range finder systems. This system is so effective and efficient that it can originally and digitally process and find out all golf shots along with their ascent or descent in the track. All these functions are performed along with the accuracy of the data. You can easily and efficiently know your actual distance every time by using the accurate and modern golf laser range finder of the brand of IDTECH. The first and foremost priority mode of this range finder shows the range of results and these results are obtained even in a single measurement. This instrument is so useful for measuring distances that its accuracy can even be checked on a pin on the back of a green forest to the next destination.
Golf is basically a precision sport game and is played on the basis of accurate determination and estimation of distances. This can be possible only if you are playing the game with the help of the classic and accurate golf laser range finder. With the help of this you can easily get the range and position of the ball in the whole golf course. The only requirement is that your range finder should be accurate enough to calculate and estimate the distances. Source: http://rangefinderclub.com/ .
Golf competition is generally played at the lowest score. In this game an individual is known simply as a stroke play. It is also known as the match play. The major thing is that the game of golf requires a lot of precision so far it is concerned about the range finding. Therefore an accurate range finder is very essential for this game. Some people think that rangefinders are just an option. According to them it is very difficult to know the exact location and range of the ball. But still people think it better to have the range finder.