text:
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00221689
Recruitment Status : Terminated (very slow recruitment and treatments beyond expiry date)
First Posted : September 22, 2005
Last Update Posted : June 13, 2007
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Traumatic Brain Injury Cerebral Anoxia Coma Hypertonia Dysautonomia
|Drug: baclofen (drug)
|Phase 2
Background. Severe brain trauma and especially serious brain lesions inducing coma lead to many cases of disability. A large number of these patients (about 30%) present neurovegetative and hypertonic episodes that are associated to a bad vital prognosis and the degree of disability. Several teams including two in France have reported the efficacy of intrathecal baclofen on such neurovegetative episodes that to date have not been able to be treated efficiently.
Objectives. The main objective of this trial is to assess the efficacy of infused intrathecal baclofen on the number of neurovegetative episodes in seriously brain-injured patients. The secondary aims are to evaluate the efficacy of the treatment on hypertonia, to assess changes in waking and treatment safety.
Study design. Double-blind randomized trial on two parallel groups. The second part of the study is open label: both groups receive the experimental treatment.
Experimental group: continuous progressive dose of intrathecal baclofen for one week; constant dose of baclofen during the second week receives at a dose determined after the first week. Treatment is stopped after two weeks, but patients are assessed until the end of the third week.
Control group: intrathecal placebo for one week; progressive dose of intrathecal baclofen during the second week. Treatment is stopped after two weeks, but patients are assessed until the end of the third week.
Outcomes. The main outcome is the number of neurovegetative episodes in the last 48 hours of the first week of treatment. Secondary outcomes are hypertonia as measured by the Ashworth scale on D2 to D5 of all three weeks. Waking will be assessed by the WHIM scale on D5 each week. Adverse events are assessed throughout the 3 weeks of study.
Eligibility criteria. Inclusion criteria are focal or diffuse encephalic lesions leading to coma (Glasgow score <8), age 18 years or over, in waking phase (spontaneous eye-opening) since at least one month and less than six months, severe hypertonia of the lower members (mean Ashworth score >= 3) with neurovegetative episodes (at least 10 in 48 hours) and/or decortication after failure of treatment per os (clonidine, beta-blocker, baclofen per os). Non inclusion criteria are surgical, anesthetic or allergic contraindication to baclofen, uncontrolled sepsis directly threatening the implanted device or associated medullary trauma.
Expected results. Throughout the trial the patients will be hospitalized in the neurosurgical or neurological intensive care departments. Expected results are a very clear decrease in the number of neurovegetative episodes and a substantial reduction in hypertonia, at least in the lower limbs. It will also be possible to quantify the consequences of these improvements on waking.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|4 participants
|Intervention Model:
|Parallel Assignment
|Primary Purpose:
|Official Title:
|Early Treatment of Paroxysmal Dysautonomia and Hypertonia for Severe Brain Injured Patients by Intrathecal Baclofen Therapy
|Study Start Date :
|March 2003
|Actual Study Completion Date :
|February 2004
- Number of neurovegetative episodes [ Time Frame: day 6 and day 7 ]
- Ashworth scale
- Whim scale
- Adverse events
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- severe brain injury with coma (Glasgow score <8)
- Early phase of recovery (spontaneous eye-opening) since at least one month and less than six months
- severe hypertonia of the lower limbs (mean Ashworth score >= 3) with neurovegetative episodes (at least 10 in 48 hours) and/or decortication after failure of treatment per os (clonidine, beta-blocker, baclofen per os)
- written informed consent (next of kin)
Exclusion Criteria:
- surgical, anesthetic or allergic contraindication to baclofen
- uncontrolled sepsis directly threatening the implanted device
- associated medullary trauma
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00221689
|Service de neurochirurgie B, Hôpital Pellergin Tripode
|Bordeaux, France, 33076
|Principal Investigator:
|Emmanuel Cuny, Professor
|University Hospital, Bordeaux
|Study Chair:
|Paul Perez, Dr
|University Hospital, Bordeaux
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 22, 2005 Key Record Dates
|Last Update Posted:
|June 13, 2007
|Last Verified:
|June 2007
Severe brain injury
Randomized Controlled Trials
Brain Injuries
Brain Injuries, Traumatic
Primary Dysautonomias
Autonomic Nervous System Diseases
Muscle Hypertonia
Hypoxia, Brain
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Wounds and Injuries
Neuromuscular Manifestations
Neurologic Manifestations
Muscle Relaxants, Central
Physiological Effects of Drugs
Neuromuscular Agents
Peripheral Nervous System Agents
GABA-B Receptor Agonists
GABA Agonists
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action


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The tasty edible canvas, in the form of impressionistic "Dog Face Cakes," manages to get people excited and surprised.
"People love to see their beloved pets captured in an artistic form," Fischer said.
Dog Face Cakes have even been requested as wedding cakes. "Since they cannot have their dogs at the wedding, this is a sweet way to include their pet," she said.
Fischer, 23, was raised in a family that cultivated her passion for art and baking.
Her mother is a baker and her father a sculptor. Fischer 's mom, Patti Paige, began Baked Ideas in 1979, out of SoHo.
The Brooklyn based artist grew up around the business and all the employees in "a kind of big family."
Fischer's affection for dogs came early on. "I got my first dog, a Jack Russell named Julia, when I was five, after much begging and pleading," she said. "She was the subject of drawings, paintings, poems and stories for the next 14 years. "
In college, Fischer studied Fine Arts at Maryland Institute College of Art, and created artwork outside of baking, including sculpture, painting and drawing. She began fostering dogs in Baltimore and kept her second foster, a pit bull named Luka.
Although Baked Ideas is her mom's bakery, Fischer comes in regularly to work on special projects and she does much of the design and styling of the cakes and cookies.
For the Dog Face Cakes, Fischer uses classic flavors like chocolate, vanilla and icing made of ganache, buttercream or fondant. The cakes are baked with "fresh and natural ingredients" at Baked Ideas.
Fischer misses the foster work, but with her own two rescued dogs and a hectic schedule, she has no time. "I still love all dogs and have contributed several cakes to various shelter fundraisers," she added.
A portion of the sales goes to Animal Haven, a Soho shelter for dogs and cats.
(Cynthia Via)
Dog Face Cakes can be ordered by phone or e-mail. Examples of custom jobs, and contact info found at www.bakedideas.com.>

subset: commoncrawl


text:
Musa species
Fruits and Vegetables, Trees and Shrubs
Soak seed at least 24 hours, up to 3 days, then sprout in moist sand, 70-75F/21-24C, and check frequently for root or shoot development. Roots are hairy and slender, shoots are smooth and fat. Plant up when sprouted, with seed immediately below soil surface. Some cultivars, i.e. Musa x paradisiaca Dwarf Cavendish, can produce fruit even if grown pot-bound and indoors year-round
Suckers a few inches long may be split from the main stem and potted, each with an adequate root supply. Divide in spring, or grow from dormant cuttings taken in the fall, rooted indoors. Grow in good light to full sun, fertile and well-draining soil. Zone 9-10
Related Topics
|Copyright © 2020,
All rights reserved


text: Catalog Auction info Valley Mfg & Eng(#35) 05/30/2019 12:00 AM PDT - 07/09/2019 3:08 PM PDT CLOSED!Starts Ending 07/09/2019 1:19 PM PDT Lot 7a of 110: Westhoff mod. 100 Mini Horizontal Drill Click image to enlarge PreviousNext Lot closed - Winning bid:N/A Valley Mfg & Eng(#35) 05/30/2019 12:00 AM PDT - 07/09/2019 3:08 PM PDT CLOSED! Starts Ending 07/09/2019 1:19 PM PDT Description Description: Westhoff mod. 100 Mini Horizontal Drill Categories: Terms and conditions VALLEY MFG. & ENG. INC. AUCTION TERMS AND CONDITIONS ONLINE ONLY SALE! SALE BEGINS ENDING: Tuesday, July 9th @ 10:30am INSPECTION DATE: Monday, July 8th from 9am-4pm & the morning of the sale. EQUIPMENT LOCATION: 9105 De Garmo Ave., Sun Valley, CA 91352 ******All sales in U.S. dollars only!!****** *All descriptions are believed to be correct, but no guarantees or warranties are made by auctioneer as to nomenclature or age. Everything sold on an "as is" basis. *Please remember that a bid is a verbal contract; once you become the successful bidder, you must pay for your items. If you find that the riggers you contact are charging you high fees, that doesn't mean that you can abandon your items. Once you win, you are responsible for paying. *Bidding online will take place through www.auctionhq.com. ***FULL AND FINAL PAYMENT MUST BE MADE IN CASH, CASHIER'S CHECK, WIRE TRANSFER ONLY. *** PAYMENT MUST BE MADE, OR WIRE INITIATED, BY CLOSE OF BUSINESS THE DAY AFTER THE SALE. *ONLINE BUYERS PREMIUM IS 18% OF HAMMER PRICE. SALES TAX ALL SALES WILL BE SUBJECT TO LOCAL SALES TAX Sun Valley, CA Sales Tax: 9.5% *For those doing business in California: The only way to be exempt from sales tax is to furnish us with a copy of your resale license. Simply telling us your resale number is not sufficient; you must provide an actual copy for our records. We do not keep resale licenses on file at the office. In addition, your resale license must have current information, including the name of your company and address. If the name and address on your resale license don't match the name and address you register with, that license is unacceptable. If your business card and/or business name don't explicitly state that you are in the business of buying and selling the type of machinery you are buying from us, we may choose to refuse your resale license. In other words, if you are in the business of woodworking and you buy office furniture at our auction, do not expect to have your resale license accepted. You may want to provide us with a copy of an ad for your company, demonstrating that you are in the business of buying and selling the type of equipment you are purchasing from us, as proof. We reserve the right to deny any resale license that appears questionable. *For those doing business outside of California: The only way to be exempt from sales tax is to furnish us with a copy of your Bill of Lading, demonstrating that the items purchased at auction have crossed state lines. Do not fax us a copy of your state resale license; California doesn't accept resale licenses from other states. Also, moving the items across a state border yourself doesn't count. You must have a common carrier move the items, and then give you a Bill of Lading which you then send us a copy of. ***IMPORTANT***In ALL cases, without exception, if you cannot furnish us with the required tax exemption proof BEFORE payment is made, then you MUST pay the tax. If you can furnish us with the required documentation after payment is made, but within 21 days of the sale, a refund will be promptly issued. There are NO exceptions to this. If you make a wire transfer to us, or obtain a cashiers' check, without including the tax and before giving us the required documents, you will not be allowed to remove any equipment until the situation is corrected. Obviously, if you are relying on a Bill of Lading for tax exemption, you will not be able to provide copies of documents until after the items are moved, and so please be aware of this rule when making payment. Also, we remit the sales tax we collect to the Board of Equalization on a monthly basis, so if you take longer than 21 days to get tax exemption proof to us, it will be too late: we will not take steps to try and retrieve your sales tax from the Board of Equalization once the taxes are turned in. ***If we have any doubts as to the veracity of tax exemption claims, we reserve the right to refuse tax exemption status.*** ADDITIONAL INFO FOR THOSE BUYING VEHICLES: as of 10/2012, we are required to collect sales tax on vehicles except when a buyer has a DMV-issued vehicle dealers' license. A regular CA SBOE issued resale permit will not remove the sales tax from vehicle purchases. LOT REMOVAL CHECK-OUT WILL BE ANNOUNCED CLOSER TO THE SALE DATE. Removal of lots is entirely the responsibility of the bidder. We do not package, load or ship. There will be no equipment, like forklifts, onsite to facilitate your lot removal. It is up to you to hire a rigger or otherwise provide for the removal of your items. Additionally, if you are moving items out of the country, please understand that we do not act as customs brokers. You will have to facilitate any and all paperwork involved with removing your items across borders. While we do not work with or endorse any riggers, we can provide you with contact information for riggers who have requested that we do so: Advanced Riggers & Millwrights Mark Grzybowski – 951-361-9187 / 951-505-8353 Red Line Machinery Movers Bernie Crist - 323-888-8772 Beltran Machinery Moving Gabriel Beltran - 888-815-0079 Santa Fe Machinery Movers Carlos Sanchez: 562-927-0020 Inland Rigging Steven Fangmeyer: 951-581-2185 M&M Machinery Moving Inc. Mike Ortega - 213-494-7581 IMPORTANT: Due to buyers being lax about removing their items in a timely fashion, we are implementing a $500 per day fee for entry into the facility every day past the time allotted for check out. GOOD LUCK AND HAPPY BIDDING!


text:
Atheist Billboard Slams Rick Perry's Comments That Prayer Can Solve Gun Violence
American Atheists, one of the country's biggest secular groups, put up a new billboard in Texas Monday morning slamming Texas Gov. Rick Perry for saying that prayer can solve America's gun violence.
"His solution to school shootings? Prayer," the billboard reads. The secular organization's ad refers to comments the former GOP presidential candidate made back in January responding to President Barack Obama's push for stricter gun control.
"As a free people, let us choose what kind of people we will be. Laws, the only redoubt of secularism, will not suffice. Let us all return to our places of worship and pray for help. Above all, let us pray for our children," Perry said then.
America suffered a particularly violent year in terms of mass shootings in 2012 – on Dec. 14, a 20-year-old shooter massacred 26 people at an elementary school in Newtown, Conn., including 20 children. The incident rocked the nation and left many Americans wondering what, if anything, can be done to prevent such tragedies in the future.
Conservatives and liberals have clashed over what the proper solution would be, with gun advocates warning that any restrictions on firearms would be an infringement of the 2nd Amendment.
American Atheists were especially critical of Governor Perry's suggestion to focus on prayer rather than new gun legislation.
"Rick Perry's statement is out of touch with reality," American Atheists President Dave Silverman said, according to Raw Story. "Prayer does not solve problems, rather it masks them. Asking Americans to pray to solve the violence problem is an admission of administrative impotence. Playing the God card is not a valid substitute for real action."
Next to the Perry billboard is an ad featuring former Arkansas governor and Fox News host Mike Huckabee, which reads "Amend the Constitution to (what I say are) God's Standards."
The ad refers to Huckabee's 2008 GOP presidential campaign comments:
"I have opponents in this race who do not want to change the Constitution. But I believe it's a lot easier to change the Constitution than it would be to change the word of the living God. And that's what we need to do is amend the Constitution so it's in God's standards rather than trying to change God's standards so it lines up with some contemporary view of how we treat each other and how we treat the family."
Earlier in March, AA had to apologize for misquoting former Alaska governor Sarah Palin in another billboard in Texas. The quote attributed to Palin read:
"We should create law based on the God of the Bible," with a sign to "Go Godless Instead," beneath her photo.
What Palin really said, however, was that America's founding fathers "would create law based on the God of the Bible and the Ten Commandments" (emphasis not Palin's) as opposed to "should."
Gov. Perry has not yet responded to the ad.


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Depending on your vantage point, the view of the Wyman-Gordon property off Madison Street varies throughout the Canal District. The same could be said for perspectives on how to develop the parcels — dormant swaths of former industrial land in an otherwise vibrant neighborhood that were recently eyed as a possible location for a slots parlor and boutique hotel.
Depending on your vantage point, the view of the Wyman-Gordon property off Madison Street varies throughout the Canal District.
The same could be said for perspectives on how to develop the parcels — dormant swaths of former industrial land in an otherwise vibrant neighborhood that were recently eyed as a possible location for a slots parlor and boutique hotel.
Soon after news broke this month that Cambridge developer Richard L. Friedman was considering the site as a location for a slots parlor, the City Council, while expressing somewhat cautious optimism that the vacant lots would be developed, passed an order to explore the possibility of taking the parcels — owned by the Oregon-based parent company of Wyman-Gordon — by eminent domain, a move that would presumably give the city more control over how the land is developed.
The first thing John G. Giangregorio wanted to clear up in a recent telephone interview is that the Wyman-Gordon parcels are not "downtown." They are firmly part of the Canal District, the collection of neighborhoods that runs from Union Station to Brosnihan Square and includes the Green Island neighborhood in the Millbury Street-Crompton Park area, said Mr. Giangregorio, president of the Canal District Alliance Inc. and chairman of the Canal District Business Association.
"We are not abutters," he said. "Wyman-Gordon is in the Canal District."
Mr. Giangregorio said it's important for the district to build its brand as a lively mix of entertainment venues, restaurants, businesses and watering holes. Part of that is actually having a visible canal to live up to its name. The district seeks to be included with possible plans by the National Park Service to make the Blackstone River Valley a national park. Mr. Giangregorio, who owns Three G's Sports Bar on Millbury Street, said attracting quality development could be an opportunity for the district to get the canal reopening paid for with private funds, similar to how mitigation funds the city secured from the CSX rail yard expansion on Franklin Street have been used to fund initiatives and improvements. He said cities such as Indianapolis, Oklahoma City and San Antonio have undertaken similar projects with success.
"It's a model that works," he said.
Mr. Giangregorio said he doesn't have a problem with the idea of a gaming operation coming to the city, or the district.
"We're pretty excited that a quality developer is looking at a project in Worcester," he said. "Certainly any project that complements the progress of the Canal District will integrate itself well."
He said the gaming legislation contains regulations that make sure the development meshes well with the surrounding community, and he said the City Council will need to "hold the developer's feet to the fire." He said there should be local preference for jobs during and after construction, and there should be requirements that the gaming operation use local goods and services. But generally, he said it could be a boon to the district and, by extension, the city.
"We're curious, and eager to see what happens," Mr. Giangregorio said.
From his residence in the renovated former Ash Street School atop a hill between Green and Madison streets, Allen W. Fletcher has a pretty good view of the Wyman-Gordon properties. The longtime Canal District advocate and former publisher of Worcester Magazine said in a telephone interview Friday he's not so sure slots or a casino operation are the right fit for the city.
He said he fears harm to the surrounding neighborhood — there would likely be little economic spinoff and, Mr. Fletcher added, he fears such a development would inevitably attract "opportunistic, casual crime" in the surrounding neighborhoods.
A better fit for the neighborhood would include some sort of mixed-use development. He said the site might be a good spot for an ice skating complex, since the Worcester Business Development Corp.'s draft master plan proposing rinks in the McGrath municipal lot next to the library has generated some pushback. He questioned the economic benefits of the slots project for the area. Historically, gaming operations tend to be insular, he said.
"I don't know what kind of slots parlor it is intended to be," Mr. Fletcher said. "But the whole intention is to keep people captive, to not let them out to eat — it's totally self-contained."
Neil Smith, owner of Goldstein's Scrap Metal on Lamartine Street, said Friday any development on the Wyman-Gordon land would be good for the area, and said he wasn't opposed to the idea of a gaming operation. He said he also hopes that the development would unlock several Wyman-Gordon owned properties in the neighborhood for development, possibly for residential or retail uses.
Lorraine Laurie, a longtime Green Island advocate, said she hasn't heard of a groundswell of resident opposition to the idea of a gaming operation. But she also said the neighborhood has more immediate needs, such as a bank or a grocery store.
"Something on our side of the city," Ms. Laurie said.
Whatever happens on the site, Christian Gakpo and his family will look at it every day from their home at 10 Grosvenor St. Mr. Gakpo's wife is a pastor with the Presbyterian Church of Ghana on nearby Lafayette Street, and the house is directly across the street from the Wyman-Gordon property that would likely be developed.
"Personally, I'm not a person who believes in gambling," Mr. Gakpo said Saturday night of the snow-covered asphalt expanse across the street. He added that he would be happier with a mixed-use development there. But he wondered how increased access to such a large development would even be possible without some sort of flyover from the highway that bypasses Kelley Square.
"In my opinion, it wouldn't be a good idea, the primary reason being access to (Interstate) 290 through Kelley Square. It's a huge factor. I know people who don't want to come here because of Kelley Square."
Along with Mr. Fletcher and Mr. Smith, Mr. Giangregorio cautioned that all the talk of slots is just speculation until the $400,000 application fee required by the state is turned in and the rights to establish a gaming site are secured. Massachusetts law allows for up to three resort casinos, but only one slots parlor, and the state's existing race tracks are thought to be favored for the slots license, administered by the Massachusetts Gaming Commission. Plainridge Racecourse in Plainville is the only applicant so far for that license. And ultimately, if the plan progresses far enough, city voters will have the final say in a citywide election.
Mr. Giangregorio said Mr. Friedman is a quality developer, and said it's important that the city build relationships with developers like him. He said that if Mr. Friedman can't get slots, perhaps he can bring a mixed-use development to the site.
"We need to welcome businesses," Mr. Giangregorio said.
Mr. Fletcher said he had a "totally negative" reaction to the slots parlor plan, but is willing to at least listen.
"My mind is open, my prejudice is quite large and well-informed," Mr. Fletcher said. "Show me where it has had a positive effect."


text:
WWE Tables Ladders and Chairs 2009 DVD
WWE presents the "Tables, Ladders & Chairs" PPV held on Dec. 13, 2009 at the AT&T Center in San Antonio, TX. TLC: Tables, Ladders & Chairs will feature wrestlers from all 3 Brands Raw, SmackDown & ECW, each match being a main-event contested as Tables, Ladders, and Chairs matches.
- ECW Title - Ladder Match
Christian vs. Shelton Benjamin
- Intercontinental Title
John Morrison vs. Drew McIntyre
- Women's Title
Michelle McCool vs. Mickie James
- WWE Title
John Cena vs. Sheamus
- World Title - Chair Match
Undertaker vs. Batista
- Randy Orton vs. Kofi Kingston
- Unifed Tag Titles - TLC Match
Chris Jericho & Big Show vs. DX (Shawn Michaels & Triple H)
Average Customer Review: 2 Reviews
Write an online review and share your thoughts with others.


text:
Vivitar UK to auction 13,000 new-in-box cameras, camcorders
If you've ever had a desire to buy a pallet's worth of cameras, your opportunity may be coming up sooner than you thought. PhotographyBlog is reporting today that around 13,000 Vivitar cameras and camcorders will be auctioned off beginning later in the month.
According to a press release filed by the agency, property firm King Sturge will be liquidating the assets of Vivitar's now-defunct UK operations, including a huge number of new-in-box products, in an online auction beginning October 14.
Rights to the Vivitar brand were recently acquired from former parent company Syntax-Brillian by Sakar International, the conglomerate behind several well-known franchises including Crayola, Hello Kitty, and the "For Dummies" series of how-to manuals.
With the acquisition of Vivitar, Sakar is announcing plans to expand the brand's presence and market coverage worldwide with a new series of cameras retailing between $70 and $300 – a marked change in approach from Vivitar's former bargain-only branding (according to the Sakar press release, the company's current products retail between $20 and $100).
Check out the full story for more on both the acquisition and the sale.


text:
Joe's Jeans Toles Black Oxfords
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text: Brand New Design Optimized for AM3 CPU O.C. DDR2 1200 AMD AM3 CPU support EPU TurboV Turbo Key ASUS Anti-Surge Protection AMD 140W CPU Support Shop Modal header CPU, Chipset and Graphics Features AMD® Phenom™ II/Athlon™ II/Sempron™ 100 Series Processors(AM3 CPU) This motherboard supports AMD® AM3 multi-core processors with unique L3 cache and delivers better overclocking capabilities with less power consumption. It features dual-channel DDR2 1066 memory support and accelerates data transfer rate up to 5200MT/s via HyperTransport™ 3.0 based system bus. This motherboard also supports AMD® CPUs in the new 45nm manufacturing process. NVIDIA GeForce® 8300 NVIDIA® GeForce 8300 offers the latest support of Hybrid SLI Technology, DirectX® 10 graphics features, HD video playback with HDMI/DVI output. It also supports HyperTransport™ 3.0 interface, PCI Express™ 2.0 bus architecture, Serial ATA 3 Gb/s devices and is optimized with AMD's latest AM3/AM2+ and multi-core CPUs to provide excellent system performance. O.C. DDR2 1200 To attain top performance, ASUS engineers have successfully unleashed DDR2 1200(O.C.) MHz to meet the higher bandwidth requirements of the latest operation system, 3D graphics, multimedia, and Internet applications. *Ensure that you download and update to the latest BIOS at www.asus.com and purchase the memory modules listed in the ASUS official memory Qualified Vendors Lists (QVL).** We recommend that you install the DDR2 1200 memory modules on the yellow slots for better performance. PCIe 2.0 support This motherboard supports the latest PCIe 2.0 devices for double speed and bandwidth which enhances system performance. Hybrid SLI Support GeForce® BoostBoosted Performance with Onboard GPU and Discrete Graphics Card HybridPower™Intelligent Graphics Power-Savings and Quiet OperationsHybrid SLI™ technology is a unique hybrid multi-GPU technology. It includes two primary features: GeForece Boost and HybridPower™. GeForece Boost turbo-charges performance of discrete graphics cards when combined with the motherboard GPUs. HybridPower™ unleashes graphics performance for demanding 3D applications and enables low-power operation for everyday computing needs.* GeForce®(R) Boost and HybridPower™ are on select GeForce®(R) GPUs. Visit www.nvidia.com/hybridsli for more information. AMD® Phenom™ X4/ Phenom™ X3/ Athlon™ X2/ Athlon™/ Sempron™ processors (socket AM2+/AM2) This motherboard supports AMD® Socket AM2+ multi-core processors. It features dual-channel DDR2 1066 memory support, data transfer rate up to 5200MT/s via HyperTransport™ 3.0 based system bus, and AMD® Cool ´n´ QuietTM Technology. HyperTransport 3.0 HyperTransport™ 3.0 technology provides 2.6 times more bandwidth than HyperTransport™ 1.0, radically improving system efficiency to create a smoother, faster computing environment. HDMI Support Enjoy Full HD 1080p Multimedia Home-Theater EntertainmentHigh-Definition Multimedia Interface (HDMI) is a set of digital video standards that delivers multi-channel audio and uncompressed digital video for full HD 1080p visuals through through a single cable. Supporting HDCP copy protection such as HD DVD and Blu-ray Discs, HDMI provides you with the highest-quality home theater experience. HDMI/DVI/RGB Support Flexible Graphics AlternativesThis motherboard supports multiple digital and analog display output interfaces - HDMI, DVI, and D-Sub. With such diversity of display outputs, you are able to choose and upgrade display devices freely. ASUS Power Solutions 4+1 Phase Power Design Longer Life & Higher Efficiency!Unleashes ultimate memory performances with independent power to core components, while providing fast transient response and stability for the CPU under heavy loading or overclocking modes. ASUS Anti-Surge Protection This special design prevents expensive devices and the motherboard from damage caused by power surges. ASUS Green Design EPU The ASUS EPU (Energy Processing Unit) provides total system power management by detecting current PC loadings and intelligently moderating power in real-time. It automatically provides the most appropriate power usage for the CPU, VGA card, hard drives, and CPU/chassis fans- helping save power and money!*ASUS EPU is supported by AM2+/AM3 CPU only. AI Nap Minimize noise and power consumption when temporarily away! With AI Nap, the system can continue running at minimum power and noise when you are temporarily away. To wake the system and return to the OS environment, simply click the mouse or press a key. ASUS Overclocking Tools TurboV Feel the adrenaline rush of real-time O.C. - now a reality with the ASUS TurboV. This easy O.C. tool allows you to overclock without exiting or rebooting the OS; and its user-friendly interface makes overclock with just a few clicks away. Moreover, the ASUS OC profiles in TurboV provides the best O.C. settings in different scenarios. Turbo Key ASUS Turbo Key allows the user to turn the PC power button into an overclocking button. After the easy setup, Turbo Key can boost performances without interrupting ongoing work or games - with just one touch!! Express Gate Express Gate 0 to Internet in Seconds!Express Gate™ is an ASUS exclusive OS that provides you with quick access to the Internet and key applications before entering Windows®. Industry Standard High Definition Audio Enjoy high-end sound system on your PC!The onboard 8-channel HD audio (High Definition Audio, previously codenamed Azalia) CODEC enables high-quality 192KHz/24-bit audio output, jack-sensing feature, retasking functions and multi-streaming technology that simultaneously sends different audio streams to different destinations. You can now talk to your partners on the headphone while playing a multi-channel network games. All of these are done on one computer. S/PDIF-out on Back I/O Port This motherboard provides convenient connectivity to external home theater audio systems via coaxial and optical S/PDIF-out (SONY-PHILIPS Digital Interface) jacks. It allows to transfer digital audio without converting to analog format and keeps the best signal quality. ASUS EZ DIY Q-Connector ASUS Q-Connector allows you to easily connect or disconnect the chassis front panel cables to the motherboard. This unique module eliminates the trouble of connecting the system panel cables one at a time and avoiding wrong cable connections O.C. Profile Conveniently store or load multiple BIOS settingsFreely share and distribute favorite overclocking settings The motherboard features the ASUS O.C. Profile that allows users to conveniently store or load multiple BIOS settings. The BIOS settings can be stored in the CMOS or a separate file, giving users freedom to share and distribute their favorite overclocking settings. CrashFree BIOS 2 This feature allows you to restore the original BIOS data from the support CD in case when the BIOS codes and the data are corrupted. This protection eliminates the need to buy a replacement ROM chip. ASUS EZ Flash2 With ASUS EZ Flash, you can update BIOS before entering operating system. No more DOS-based flash utility and bootable diskette required. ASUS Quiet Thermal Solutions ASUS Q-Fan 2 ASUS Q-Fan2 technology intelligently adjusts both CPU fan and chassis fan speeds according to system loading to ensure quiet, cool and efficient operation. Stylish Heatsink The streamline-shaped heatsink features 0-dB thermal solution that offers users a noiseless PC environment. Not only the beautifully curved fins upgrade the visual enjoyment for motherboard users, but also the special Streamline Airflow Guiding design lowers the temperature of the north bridge chipset through high efficient heat-exchange. Combined with usability and aesthetics, the ASUS streamline-shaped heat-sink will give users an extremely silent and cooling experience with the elegant appearance! Other ASUS Features Uses 100% All High-quality Conductive Polymer Capacitors!(VRM 5000hrs lifespan @105°C, 500,000hrs @65°C) This motherboard uses all high-quality conductive polymer capacitors onboard for durability, improved lifespan, and enhanced thermal capacity. C.P.R.(CPU Parameter Recall) When the system hangs due to overclocking failure, there is no need to open the case to clear CMOS data. Just simply restart the system, the BIOS would show the previous setting and then users can amend the CPU setting again. DTS Surround Sensation UltraPC DTS Surround Sensation UltraPC delivers exceptional 5.1 surround experience through the most common PC audio setups - your existing stereo speakers or headphones. In addition to virtual surround, "Bass enhancement" provides stronger low frequency bass sound, and "Voice clarification" provides clear human dialogue even with loud background sound. With these technologies, you may experience a better home-theater audio with ease.To experience DTS Surround Sensation UltraPC, download the updated audio driver & latest BIOS at www.asus.com. MyLogo2 Personalize your system with customizable boot logo You can convert your favorite photo into a 256-color boot logo for a more colorful and vivid image on your screen. RoHS GreenASUS The motherboard and its packaging comply with the European Union´s Restriction on the use of Hazardous Substances (RoHS). This is in line with the ASUS vision of creating environment-friendly and recyclable products and packaging to safeguard consumers´ health while minimizing the impact on the environment.


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Connaughton said this contact group was to meet at
the end of January to lay out some of the key objectives
outlined in the U.S. counterpiracy action plan.
"There are several areas they are looking at,"
Connaughton said. "One is greater naval cooperation
— respectively, how to deal with jurisdictional issues
— and industry outreach. MARAD has been tasked
with essentially doing outreach in trying to assist the
international shipping industry to come up with best
practices with coordinated communications as well as
coordination with the navies."
Since 1991, there has been little government authority
in Somalia. The fractured country has struggled for
more than a century with reunification following a
long history of colonial divisions, aggravated further
by clan distinctions and militia forces. Consequently,
in recent years the number of ships seized off its coast
has surged and the practice of pirates holding crews for
ransom has confounded maritime officials.
In 2008 alone there were 109 attacks in Somali
waters, during which 42 vessels were hijacked and 828
crew members taken hostage, according to Pottengal
Mukundan, director of the IMB. The IMB's Piracy
Reporting Centre was established in 1991 in Kuala
Lumpur, Malaysia, at a time when attacks were prevalent in Southeast Asia and the South China seas.
The Piracy Reporting Centre essentially collects
emergency calls from masters and crew on vessels that
are under attack, and then passes it on to law enforcement agencies in the area of concern.
At the close of December, 14 vessels were being held
in the waters off Somalia, said Mukundan. Among
them was the Saudi Arabian oil supertanker Sirius Star,
which was seized in November.
Naval intelligence and military officials were astonished by the crime. At three times the size of an aircraft
carrier and transporting 2 million barrels of oil, the vessel
was overcome by a small pirate gang that had to sail for
several days to reach the ship, which was traveling about
520 miles off the coast of Kenya at the time of the attack.
Somali pirates who overtook the Chinese fishing vessel Tian Yu 8 hold its crew on the ship's deck Nov. 17. Tian Yu 8
was attacked Nov. 16 in the U.S. Fifth Fleet area of responsibility and forced to proceed to an anchorage off the Somali
coast. It was still being held as of mid-January.


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Senate Dems gear up to battle House GOP on climate regs
House Republicans ready to unravel U.S. EPA's work on greenhouse gas emissions are beginning to find a newly invigorated opposition on the other side of the Capitol.
Senate Environment and Public Works Chairwoman Barbara Boxer (D-Calif.) yesterday put the new House Energy and Commerce Committee chairman on notice by name, vowing to "use every tool available to me" to prevent a derailing of carbon emissions regulations by Rep. Fred Upton (R-Mich.). Boxer's gloves-off performance drew consternation from House and Senate Republicans alike, but her fellow upper-chamber Democrats echoed her desire to go on offense in protecting EPA.
"I never defend -- I always attack," Sen. Tom Harkin (D-Iowa) said in an interview, adding of Republicans: "If they want to repeal EPA [regulations] and stuff like that, I think we ought to go after them. I say, give them rope."
Sen. Frank Lautenberg (D-N.J.), a longtime Environment and Public Works subpanel chairman, likewise sounded a similar note. "People on the other side can talk about costs" of extending EPA authority over industry," he said. "What's the cost of a life? What's the cost of a disability? ... We're not going to cower in a corner."
Lautenberg also underscored the importance of a proactive message that emphasizes the benefits of EPA's limits on emissions from power plants, oil refineries, chemical facilities and other "stationary sources."
Democrats should "make sure the public understands" the negative consequences of undoing Obama administration rules written to protect public health, Lautenberg said. "We're in great danger, and it fails to reach the public's interest because there's a tendency to look at things on a much more short-term basis," as opposed to the long-term footprint of a changing climate, he added.
Senate Democrats' willingness to take on the new House majority represents a notable shift from the previous Congress, when the president's party spent more time calming internal tensions. But the rise of House Speaker John Boehner's (R-Ohio) regime appears to have lit a fire underneath Senate Democrats, who held a press conference yesterday morning dedicated to accusing lower-chamber Republicans of budget gimmickry in their opening-day rules package.
"They're not going to be able to roll back [EPA regulations] without coming through the Senate," Sen. Sheldon Whitehouse (D-R.I.) said in an interview. "There is a case to be made that, in the contest between corporate profits and children's lungs, someone should be standing up for children's lungs."
Of course, Senate Democrats face some enthusiasm for an anti-EPA push within their own ranks. A two-year delay in enforcing greenhouse gas emissions limits offered by Sen. Jay Rockefeller (D-W.Va.) attracted six co-sponsors in his party, and several more Democratic senators from manufacturing-dependent states may yet cross over to support it when an updated version is offered this year.
The Senate's strongest EPA defenders also are aware of the need to bring fellow lawmakers into the discussion as the agency begins applying its complex emissions rules to new and upgraded industrial facilities in several states.
Sen. Ben Cardin (D-Md.) described himself as a strong backer of Boxer's approach, predicting that Democrats would "do everything we can to prevent the taking away of the responsibility of EPA to protect our environment and our health." He promptly pointed out, however, that "it's going to be easier to accomplish those [EPA] goals if Congress helps."
A jab 'in the nose'?
House Republicans hit back yesterday against Boxer's attacks.
Responding to Boxer's comments that the 2007 Supreme Court decision in Massachusetts v. EPA gave the agency authority to act on emissions under the Clean Air Act, Upton chastised Boxer for not including language pre-empting that power in a climate bill that she steered through her committee last year. He noted that Reps. Henry Waxman (D-Calif.) and Ed Markey (D-Mass.) did include more pre-emption in their bill, which passed the House in 2009 (E&ENews PM, Jan. 6).
One of Upton's colleagues, Rep. Rob Bishop (R-Utah), was more directly critical. "Upton's right," he said. "She's wrong."
Echoing concerns raised by fellow conservatives and tea party activists, Bishop painted a broader picture of EPA as a poster child for executive-branch overreach. The agency and others like it, he said, "simply try to go around Congress rather than work with Congress. That has not helped the relationship, which wasn't great to begin."
Bishop had stronger words still for House Republicans' relationship with Boxer. "With Senator Boxer, there has never been a working relationship," he said. "It probably doesn't do any more damage than has been done for the last 10 years."
A senior Republican member of Boxer's own panel, Sen. Lamar Alexander of Tennessee, said he had not seen her speech but expressed some frustration in response.
"I think now is the time for cooperation whenever we can find areas on which to cooperate -- I would like to see us cooperate on a clean air bill, for example," Alexander said. "You don't usually make a good start toward that by punching the people you work with in the nose."
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#Struggles is a book written to assist readers in regaining control of their lives and their use of social media. Craig Groeschel knows that we are becoming more addictive to all kinds of social media and we're losing the connection of intimate relationships and friendships. Throughout this book, Craig explored eight Biblical values: contentment, intimacy, authenticity, integrity, encouragement, and many more to help us learn to balance our access in using social media.
The book begins discussing the topic of contentment and how many of us are looking at our friend's Facebook's, Pinterest, Instagram's, and how we're not content with what we have. We are constantly comparing what our friends are doing and what new items they have that we secretly want. Craig also shared an insightful survey about how students revealed how dissatisfied they were while looking at Facebook and how critical they felt towards themselves afterwards. The results of this survey wasn't that all surprising to me because I could see how people could easily become so consumed with looking at what their friends are doing and becoming unhappy with their own lives.
Craig Groeschel categorized people's envy into three categories: material and financial, relational, and circumstantial. This part of the book really hit home to me. I will admit that I have felt depressed while looking at what others are doing and how much farther along they appear to be in life. It is so easy to just get online and know everything that my friends are doing and being up to date. I realized that I struggle with relational envy and when I'm looking on Facebook or Instagram I always see a post about how someone else is getting into a new relationship and it's going really well, someone got engaged, someone posting about their happy marriage, and someone expecting their first child. And I'm still single and can't see to find the bliss and happiness in a relationship that other person appears to have. I know looking at my friends Facebook's continuously only leaves me with the feeling of being jealous and envying what they have that I want. At the end of the day, I feel empty and wanting something more than I currently have. Craig shared that, "You will battle with discontent until you let Christ be all that you need" (Page 31). I really loved how Craig stated the importance of thanking God for blessing the other person's life and praying that He would continue to do so. This is something I'm willing to do because I struggle with comparing and envying others.
I would recommend this life changing book to anyone who struggles with balancing their usage on social media sites. Social media is harming our relationships and friendships. This book will assist readers into recapturing control of their access to social media. I loved how Craig Groeschel shared tons of scriptures throughout the book. I liked how he presented how social media is affecting our Christian walk and how we can fix it. We don't have to completely cut off social media, we just need to limit our usage and have safeguards in place. This book will guide readers into following Christ and not being distracted by social media. If you're looking for an excellent book about social media and you're wondering how to combat all of the dangers of being too obsessed with what others are doing, then read this book!
"I received this book free from the publisher through the BookLook Bloggers book review bloggers program."
If you would like to purchase a copy of #Struggles, check it out on Amazon.com:


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A proposal by a group of U.S. marine-park and aquarium owners to import 18 beluga whales captured from the wild has been rejected by the federal government.
The National Oceanic and Atmospheric Administration's Fisheries Service has refused to grant an import permit for the whales, captured in the Sea of Okhotsk off the eastern coast of Russia, saying doing so would worsen the decline of the wild population from which they were taken.
The application had been submitted by the Georgia Aquarium in Atlanta, which proposed to transfer 11 of the whales to marine parks owned by SeaWorld Entertainment in Orlando, Fla., the Orlando Sentinel reported Wednesday.
Through breeding-loan agreements, six whales would have gone to SeaWorld San Antonio, three to SeaWorld San Diego and two to SeaWorld Orlando.
Under the Marine Mammal Protection Act, U.S. facilities can collect marine mammals from the wild for the purpose of public display, but only if the captures do not harm the wild population, or "stock," from which they are taken, federal officials said.
Michael Payne of the NOAA Fisheries Service's Office of Protected Resources said the agency ultimately concluded the imports would ultimately have a "significant adverse impact" on the wild population.
NOAA's decision was applauded by wildlife campaigners.
"The tide is turning. The public sentiment is wholly and fully against acquisition from the wild," Courtney Vail, campaigns-and-programs manager for the Whale and Dolphin Conservation Society, said. "I do think it's time that all facilities take a hard look at their policies and move toward not acquiring animals from the wild."


text:
Immune Mechanisms Important for the Pathogenesis of Graft-Versus-Host Disease
LeShara Fulton
Research Mentor
Dr. Jonathan Serody, MD
Clinical Co-mentor
Dr. Kimberly Kasow, MD
Clinical Co-Mentor
Dr. Stephanie Sarantopoulos, MD
|Home Department
|Microbiology and Immunology
|Project Description
Allogeneic hematopoietic stem-cell transplantation is the treatment of choice for patients with high risk acute leukemia, recurrent leukemia, bone marrow failure syndromes and is commonly utilized for the treatment of indolent lymphomas. One significant consequence of allogeneic stem cell (Allo SCT) transplantation is the occurrence of acute graft-versus-host disease (aGvHD), which is mediated by mature T cells present in the donor marrow or stem cell inoculums. GvHD occurs in 30-60% of individuals that undergo an allogeneic SCT and can cause significant morbidity and mortality in this patient population.
One aspect of the biology of GvHD that has received attention recently has been the role of migratory proteins found on donor T cells in the migration of donor cells to the initial sites of activation. This work has shown that donor T cells initially migrate to lymphoid tissue of the host where they are activated by host antigen presenting cells. This activation changes the expression of migratory proteins on the surface of donor T cells allowing them to migrate to GvHD target tissue. Recent work has suggested that inhibiting the migration of donor T cells into or out of the lymphoid tissue has a significant effect on the incidence and severity of acute GvHD. Coronin 1A (Coro 1A) an actin binding protein found in immune and hematopoietic tissue plays a critical role in T cell migration. Previous data has shown a protective effective of Coro 1A-/- T cells in aGvHD. Based on these data I will evaluate the function of Coro 1A in the pathogenesis of aGvHD.
Determining specific T cell populations responsible for the pathogenesis of GvHD is critical for improved therapies. Studies in our laboratory have demonstrated that TH17 cells are able to mediate GvHD, characterized by extensive skin and pulmonary inflammation. My research will continue the investigation of TH17 cells involvement in GvHD and possible targeting this cell population for novel clinical therapies.


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Where to go in Turkey
Western Turkey is the most economically developed, and most visited, part of the country. It would take weeks even to scratch the surface of the old imperial capital, İstanbul, straddling the straits linking the Black and Marmara seas, and still Turkey's cultural and commercial hub. Flanking it on opposite sides of the Sea of Marmara, the two prior seats of the Ottoman Empire, Bursa and Edirne, abound in monumental attractions and regal atmosphere. Beyond the Dardanelles and its World War I battlefields lie Turkey's two Aegean islands, Gökçeada and Bozcaada, popular for their excellent beaches, lingering Greek-ethnic identity and (except in midsummer) tranquillity.
Further south, the olive-swathed landscapes around Bergama and Ayvalık epitomize the Classical character of the North Aegean. Ancient Sardis, and the old Ottoman princely training-ground of Manisa, also make a fine pair, although İzmir serves merely as a functional introduction to the central and southern Aegean. Celebrated Ephesus tends to overshadow the equally deserving ancient Ionian sites of Priene and Didyma, or the intriguing ruins of Aphrodisias and Labranda – and don't overlook evocative hill towns like Şirince or Birgi. Also inland are tranquil, islet-dotted Bafa Gölü, the architectural showcase town of Muğla, and the compelling geological oddity of Pamukkale, where travertine formations abut Roman Hierapolis. While the coast itself is heavily developed, its star resorts – Datça is the quietest, Bodrum the most characterful – make comfortable bases.
Beyond the huge natural harbour at Marmaris, the Aegean gradually becomes the Mediterranean. Coastal cruises make popular pastimes in brazen Marmaris or more manageable Fethiye, the principal town of the Turquoise Coast, while fine beaches stretch at Dalyan and Patara, near eerie ancient Lycian tombs. Further east, Kaş and Kalkan are busy resorts, good for resting up between explorations of the mountainous hinterland. Beyond relatively untouched Çıralı beach, at ancient Olympos, fast-growing Antalya sprawls at the start of the Mediterranean Coast proper. This is graced by extensive sands and archeological sites – most notably Termessos, Perge, Side and Aspendos – though its western parts get swamped in season. Beyond castle-topped Alanya, however, tourist numbers diminish; points of interest between Silifke and Adana include Roman Uzuncaburç and the romantic offshore fortress at Kızkalesi. Further east, Arab-influenced Antakya is the heart of the Hatay, culturally part of Syria.
Inland in South Central Anatolia, the rock-hewn churches, subterranean cities and tuff-pinnacle landscapes of Cappadocia await you. The dry, salubrious climate, excellent wine, artistic and architectural treasures, plus horseriding or hot-air ballooning could occupy you for ten days, including a stop in Kayseri on the way north. You might also pause at the historic lakefront towns of Eğirdir or Beyşehir, or in Konya, renowned for its Selçuk architecture and associations with the Mevlevi dervishes.
Ankara, Turkey's capital, is a planned city whose contrived Western feel indicates the priorities of the Turkish Republic; it also features the outstanding Museum of Anatolian Civilizations. Highlights of surrounding North Central Anatolia include the bizarre temple of Aezani, near Kütahya; the Ottoman museum-town of Safranbolu; exquisitely decorated early Turkish monuments in Divriği; and remarkable Hittite sites at Hattuşaş and Alacahöyük. As you travel north, pause in the Yeşilırmak valley towns of Sivas, Tokat and Amasya. The lush shoreline of the Black Sea beyond holds little more than a chain of Byzantine-Genoese castles; the oldest, most interesting towns are Sinop, Anatolia's northernmost point, and Amasra. Fabled Trabzon, east of Sinop and once the seat of a Byzantine sub-empire, is now convenient for Aya Sofya and Sumela monasteries.
The Ankara–Sivas route positions you to head along the Euphrates River into the "back half" of Turkey. First stop in Northeastern Anatolia is likely to be Erzurum, Turkey's highest and bleakest major city, a base for visits to the temperate, church-studded valleys of southern medieval Georgia, or treks in the Kaçkar mountains. Kars is mainly visited for the sake of nearby Ani, the ruined medieval Armenian capital.
The Euphrates and Tigris basin have a real Middle Eastern flavour. Booming Gaziantep, offers world-class Roman mosaics, an atmospheric old quarter and Turkey's spiciest cuisine. Further east, biblical Urfa is distinguished by its colourful bazaar and sacred pool, while cosmopolitan Mardin overlooks the vast Mesopotamian Plain. The major attraction, however, is a dawn or sunset trip to Nemrut Dağı's colossal ancient statues. Between Mardin and Nemrut Dağı, teeming, ethnically Kurdish Diyarbakır nestles inside medieval basalt walls. The terrain becomes increasingly mountainous towards the Iranian frontier, an area dominated by the unearthly blue, alkaline expanse of Lake Van. Urartian, Selçuk and Armenian monuments abound within sight of the water, in particular the exquisite, restored Armenian church on Akdamar islet. The east-shore city of Van is notable for its massive camel-shaped rock punctured with ancient tombs. Beyond Van looms the fairy-tale Kurdish castle of Hoşap, while just outside Doğubeyazit, another isolated folly, the İshak Paşa Sarayı, stands in the shadow of Mount Ararat at the very end of Turkey.
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text:
Brunswick Bowling Jersey by Logo Infusion - 0575BR
Frequently bought together:
Brunswick Dye Sublimated Bowling Jersey - 0575BR Style
- This Dye-Sublimated Shirt is a Microfiber Short Sleeve with Moisture Management.
- Fabric Content is 100 percent polyester. Fabric Weight 180 grams.
- The Front and back is always printed with the exact same image.
Please allow 3-4 weeks for production of your dye sublimated shirt.
- Double needle stitched construction.
- Tag-less label for comfort and zero irritation.
- 100 percent polyester, does not shrink.
- Please wash cold, no bleach or fabric softener, tumble dry cool or hang dry.
- No extra charge for over-sizes.
- Different neck styles are available!
Some shirts may have slight ink bleeds and small contamination spots. These slight blemishes are normal to the dye sublimation process and usually cannot be noticed.


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The Art Collection
Apotheosis of Washington
Painted in the true fresco technique by Constantino Brumidi in 1865 in the eye of the U.S. Capitol Rotunda.
Senate Wing
It was constructed after the fire of 1814 as a means of lighting the corridors and circulating air into rooms that open onto the space.
In the pre-fire period this elliptical space housed the Senate wing's main staircase. Benjamin Henry Latrobe remarked to Thomas Jefferson that "it was one of the most remarkable parts of the Capitol." In rebuilding the wing's interior after the fire, Latrobe moved the staircase to the east and in its place erected a circular arcade holding 16 columns, which, in turn, support a dome. Desiring columns that were more slender than the Ionic order but not so elaborate as the Corinthian, Latrobe designed a capital with the leaves and flowers of the native American tobacco plant; they were modeled by Francisco Iardella in 1816. Coffers with rosettes decorate the dome and a glass skylight covers the oculus. Crowning the space is a lantern, a small circular turret ringed with windows that originally admitted natural light and air to the corridors below.
This space was heavily damaged in November of 1898 when a gas explosion blew up the Seneca stone floor and the supporting arches and blew out the glass and sashes in the lantern. Repair work was quickly accomplished before Congress returned. In a 1901 effort to make the building fireproof, Architect of the Capitol Elliott Woods rebuilt the roof, replacing the wooden structure with steel. At the same time, the former attic space was reconstructed into a useable floor, thus cutting off the light and air to the small rotunda. About that time, the six torch-like sconces were mounted on the lower walls. In 1902 the current terrazzo and mosaic floor on the second floor was installed by the Vulcanite Tile and Mosaic Company; the "temporary" cement floor is still in place on the floor below. The decorative metal grille in the center of the floor was also installed at the time, replacing an earlier grille damaged by the explosion.
In a 1907 effort to restore the historic appearance of the corridors, crypt and small rotunda, Elliott Woods removed the plaster and paint from the brick walls and installed imitation sandstone in their place. The current paint scheme in the small Senate rotunda dates from 1971. The two matching three-armed sconces mounted on the east wall were purchased from Gonzalez Antiques and installed in 1963.
The chandelier hanging in this rotunda was purchased for $1,500 from the ABC Wrecking Co., which had removed it from the Capitol Hill United Methodist Church on Seward Square in southeast Washington, D.C., before razing that building. The chandelier reputedly has 14,500 crystals and weighs nearly 2,000 pounds. It is suspended from an electrically driven winch on a steel cable, which allows it to be lowered for cleaning.
The Art Collection
Painted in the true fresco technique by Constantino Brumidi in 1865 in the eye of the U.S. Capitol Rotunda.
Senate Wing


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Fritillaria species
Plants of Home and Garden
Fritillaria biflora, Fritillaria pallidiflora, Fritillaria pontica, Fritillaria uva-vulpis and Fritillaria verticillata require much the same conditions as Fritillaria meleagris. Other species may prefer more sun; all require reasonably good light. Sow seed immediately when ripe, or in fall or winter; treat older seed for double dormancy, or propagate by bulb scaling, as per Fritillaria imperialis. Some species also produce bulblets which can be removed and planted. Zone 3-9
See Also
Fritillaria imperialis (crown imperial)
Related Topics
Bulb Scaling
|Copyright © 2020,
All rights reserved


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It looks like Kirsten Dunst heard your pleas, because she opted for Rodarte tonight when she arrived on the red carpet for the "Melancholia" Premiere during the 2011 Cannes Film Festival this evening.
This marks a Cannes debut for Rodarte.
Kiki's polka dot haltered mermaid Fall 2011 dress with a forest green wool bodice was a beautiful choice for an evening premiere.
I love the Swarovski crystal embellished zipper down the side of the dress, which is a beautiful way to disguise a zipper unlike some of the unsightly exposed zippers we usually see.
The emerald cuff was a perfect touch.
Love the smoky eyes.
Credit: Style.com & Getty


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Season 3 episodes
View:all episodes (38)
All seasons
No Old Tigers
With Martuun in prison and the gang war over, Briggs writes up a version of events that will tie up all the loose ends in one big bow that takes himself off the hook. But while the pragmatic Agent Logan is willing to put his personal feelings for Briggs aside and take the win, Mike's nagging conscience won't allow him to turn away from the truth, not with so many lives lost and Gusti waiting to take the fall for the Sarin.
Dog Catches Car
Is Soto Street about to unleash a poisonous Sarin cloud on the Sarkissians? Mike sure thinks so, and he calls in the cavalry as he and Paige speed towards Tevan's funeral hoping to avert disaster. Meanwhile, Johnny must keep his calm in a hail of gunfire as the Soto execution squad converges on the funeral home. It's only thanks to his quick thinking and the late arrival of the FBI that they manage to avoid an all-out bloodbath. But Mike's hunch about the Sarin soon proves incorrect, and frustration begins to mount when Briggs jumps in his car and speeds off to leave them without answers yet again.
The Wires
Johnny wakes on the locker room floor to see the kind eyes of Theresa Arabuena, Javier's mother and the true head of Soto Street, watching over him. It turns out that his beating at the hands of Javier and his cronies was an initiation – Johnny is officially a member of Soto Street now. But while Theresa can be affectionate to all of her surrogate sons, she rules the gang with an iron fist.
Master Of Weak Ties
As Ari triumphantly receives the tattoos that will cement his place in the Sarkissian family power structure, a much less jubilant scene unfolds across town as Paige and her housemates cover up all traces of the bloody mess in their living room and make Toros's death look like a suicide. It's a desperate act designed to keep Briggs's case afloat, but Mike has reached his limit with dead bodies and secrets, and he accuses Briggs of concealing an alternate agenda. The question is, what?
Hand Of Glory
With Agent Logan his hostage and Ari frustrated at the news that Toros will undergo an initiation ceremony cementing his position as the heir apparent, Briggs walks a delicate line to keep his case afloat. As Briggs sees it, the only way to take down the Sarkissians will be to continue to play both sides. But does he have another plan up his sleeve? Mike seems to think so, but his fears are quickly dismissed by the rest of the team who chalk it up to a hazy head owing to his recent bout with addiction. Paige is prepared to stand by Toros's side at his initiation, and Logan, for his part, is ready to endure brutal questioning if it means seeing the case through to the end. All that's left is to let the scenario play out.
Savior Complex
With the bust a failure and Briggs back in the hot seat with Toros and Ari, it looks like the Sarkissian case has gone completely to hell. But appearances can be deceiving. It turns out that Briggs was the one who tipped the Sarkissians to the bust in order to sell himself to them as something infinitely more valuable than hired muscle: an FBI informant on their payroll.
Bon Voyage
Holed up in Madison's room, Mike loses himself in a cloud of oxy smoke. But while the big picture may be getting blurry for Agent Warren, his friends back at Graceland haven't lost sight of things, and they decide it might be time for an intervention.
Shocked by the revelation of the sarin gas in Gusti's trunk, Briggs pushes Mike to notify the bureau. But Mike isn't ready to call it in – his vision led him here, and he wants to see this through to the end.
Pinon Tree
With Colby dead and Martuun planning to hand over much of Ari's territory to Toros Berbarian, it's safe to say that Briggs's plan to take down Ari has completely failed. To make matters worse, Logan is wants to pull the plug on the entire operation. Briggs digs in, ready to go to the ends of the earth to take down the Sarkissians and wash some of the blood from his hands. But with the rest of the Graceland team losing faith in Briggs and Ari ready to shoot him on sight, the path towards absolution seems murky at best.
When Ari wakes with no recollection of how he ended up with a pipe through his windshield, blood on his clothes and an empty clip in his gun, Briggs must walk the unstable mobster through the events of the previous evening. Their search soon leads them to a gas station in the mountains, and a run in with Martuun Sarkissian and his right hand man, Toros Berbarian. It turns out that Martuun is on the hunt for Layla, who didn't come home the night before. Layla's recent car crash already has Martuun seeing red, and with little love lost between Toros and Ari, the situation quickly becomes tense.
Sense Memory
Charlie heads to Miami with Amber in tow in order to track down a dealer with ties to Jermaine. But when it becomes clear that Amber knows a lot less than she let on, Charlie begins to think twice about their deal.
With Graceland coming apart at the seams, Sid bides his time until he can finish what he began with Mike. It turns out, though, that the reports of Mike's passing have been greatly exaggerated; Agent Warren is alive and mostly well, although his return from the grave will have to stay under wraps until the team can nail Sid. But with Paige crumbling under the weight of her guilt, Johnny trapped in service to Carlito and Charlie distracted by her hunt for the mysterious Brit that held her captive, the housemates may be too distracted to stand as a team against Sid before he picks them off one by one.
Chester Cheeto
After hitting yet another dead end, Charlie begins to realize that her only shot at finding Jermaine may be to make a deal with Amber. However, the idea of working with a woman who nearly got her killed is putting a bad taste in Charlie's mouth.


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Sandwich Bear
I created this fun sandwich for a picnic-style meal at a teddy bear theme baby shower. The cheerful, chubby bear is formed using a round bread and rolls filled with meats, cheese and a seasoned spread. When the guest of honor mentioned plans for a teddy theme in her nursery, I latched on to the idea for a gathering. -Susan Schuller, Brainerd, Minnesota
Total TimePrep/Total Time: 20 min.
Makes12 servings
- 1 package (8 ounces) cream cheese, softened
- 1 cup mayonnaise
- 1 tablespoon prepared mustard
- 1/4 cup chopped green onions
- 1 round loaf (10-inch diameter) unsliced bread
- 6 rolls (one 5 inches and five 3-1/2 inches)
- Leaf lettuce, optional
- 3/4 pound thinly sliced deli ham
- 1 cup shredded cheddar cheese, divided
- 3/4 pound thinly sliced deli turkey
- 2 large pitted ripe olives
- In a small bowl, beat cream cheese until light and fluffy. Stir in the mayonnaise, mustard and onions. Slice bread and rolls one-third from the bottom of each. Carefully hollow out tops of bread and rolls, leaving a 1/2-in. shell.
- Spread cream cheese mixture on cut sides; top with lettuce if desired. Fill loaf with ham and half of the cheddar cheese. Fill the rolls with turkey and remaining cheese. Replace all tops.
- To assemble bear, place loaf on a large board. Place 5-in. roll on top for head and four small rolls for paws. Cut the remaining small roll in half for ears. Use one olive for nose. Cut remaining olive in half; secure with toothpicks for eyes. Cover and refrigerate for up to 2 hours.
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Jan 15, 2012
So simple but delicious. I made extra sandwiches for the next day and my family gobbled them up! I made this for my daughter's 6th birthday party. The theme was teddy bears.
Feb 14, 2010
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Mr. Goodyear: "Hi, Dr. Grumpy referred me to a cardiologist, and I made an appointment for tomorrow. I'm stuck out of town on business now, and there's no way I'll be able to make it. Can you call them and cancel for me?"
Annie: "Sure. What doctor is your appointment with?"
Mr. Goodyear: "I have no idea. It's on my desk at home. It was someone on the list."
Annie: "What list?"
Mr. Goodyear: "The one from Major Illness Insurance, of cardiologists on the plan."
Annie: "Hang on, let me look it up online... They have 38 cardiologists in our area. Do you have any idea who it may have been?"
Mr. Goodyear: "No. Can you just call all of them for me?"


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Okay, let's go back to Business 101…
A profitable business looks like this:
Buy Low < Sell High
Profitable marketing looks like this:
Cost to Aquire Customer < Customer Lifetime Value (LTV)
"Buy low. Sell High."
What is the game? To find and attract customers for less cost than they contribute.
Where does marketing fit into business?
Marketing equals sales… No marketing equals no sales.
Let's break down marketing…
First, ATTRACT relevant people – strangers – to your business.
Convert those visitors into leads.
Leads are people who say they're interested in what you have to sell.
Close those leads to turn them into customers. Help them buy.
Finally, DELIGHT your customers. Happy customers buy more and promote your business.
iveHere's how you too can fin a job easily…
Make lots of money… and never get bored.
Marketing is a problem in every organization.
But why..?
Marketing? Isn't that just coming up with fancy ideas?
Marketing? Ah, we don't really have time for that.
Marketing? Oh yeah… that's not really necessary.
We don't need more customers! – Said no business EVER.
Businesses need more customers. But how are customers found?
Businesses need marketing. Whose job is it to find customers (hint)?
Businesses NEED Marketers!
Marketing makes the difference.
Without marketing, your business misses out on the extreme potential of the extra value created by marketing.
However, GREAT marketing makes more of a difference.
"In 5 years, inbound marketers salaries will double because they're building leverage." – Dharmesh Shah, Co-Founder, and CTO @ Hubspot
Buy lower and sell higher.
There are BIG rewards for being a smarter marketer.
So what skills are involved in marketing?
DARC Marketing Skillsets
Digital Native – You're fluent with the intent and technology, You don't struggle to keep up with trends.
Analytics – You're comfortable analyzing data and designing experiments to further your understanding.
Reach – You can build relationships with many people to increase your influence. People trust you.
Content – You can craft content – articles, videos, graphics, and other media that resonate with your audience.
How do these tie into marketing jobs..?
Remember the marketing funnel?
Roles to attract.
Crafting content
Sharing on social media
optimizing websites for search engines.
Roles to convert
Analyzing data
Conversion rate optimization (CRO)
Design landing pages
Roles to close
Email marketing
Marketing automation
Roles to delight
Customer service
Managing communities
Managing events
So… How do I get into marketing?
Four actionable things to go and try…
1 Go to bars
Marketing is a social industry.
Find local meetups, conference parties, talks, seminars, workshops and more.
Talk to professionals while they're relaxed and not busy.
It's so much easier to find and talk to people than emailing, scheduling meetings, etc.
Show initiative – just by turning up at industry events.
2 Send Better Email
Standard career advice 101.
You've probably been told to "Be professional".
You've probably been told to "Use formal language".
Does any of this sound familiar?
You're sending dozens of job applications
You're doing things just to put them on your resume
You're applying for jobs at companies you don't really want to work for.
You're tired of not hearing back from companies you've applied to. And when you do, you never get actionable feedback.
Don't limit yourself to job applications.
It's the most competitive game with the smallest opportunity.
Remember, you are solving a real business problem.
You're in the business of helping businesses grow.
It's all about selling your skills and services to businesses.
More hunter… Less gatherer.
Get your own business
Market yourself
Ask people you know in work
Send better email
Remember, all businesses need growth. But, they don't necessarily think they need marketers. So they don't necessarily post job ads to apply for.
There's a huge market of unadvertised 'opportunities' for marketers.
Forget formality.
Send better email…
1 Speak how you'd like to be spoken to – professional messages where you can share things in common will always do better. We're human after all.
2 Show your initiative – Use examples of previous work on how you're smart, and can get things done.
3 Keep it short – People, like and respond to, short and "gets to the point" messages.
4 Ask yes or no questions – Avoid back and forth decisions. Does Monday 2 pm at your office work for you? Trumps "where would you like to meet?"
3 Promote Something
Affiliate marketing is where brands pay you when you send customers to them.
Earn and learn while promoting your favorite brands.
What affiliate marketing can look like:
Attract – Creating a website. Crafting product reviews. Engaging relevant people on social media.
Convert – Creating pages to promote, specific offers and products, email opt-in forms.
Close – Email series for specific buyers personas. Invite only Facebook groups.
Delight – Create a support community for your subscribers and visitors. Create a community. Peer-to-peer product reviews.
Tips for earning and learning as an affiliate.
Go niche – Everyone promotes the big brands. You' find a higher return and less competition focusing on less well-known brands, products, and services.
Focus. Focus. Focus. – Default to asking yourself "does this get closer to making money". Yes/no questions cast the daylight you need.
Get to that first payment quickly – Nothings more motivating than seeing your first payment come in, Focus on getting to that first spot – it'll help you ask the right questions.
4 JFDI Yourself
Get into marketing by marketing yourself (Just f*cking do it).
You can get insane leverage on spending time, money, and effort to find marketing jobs.
How to make yourself attractive to companies…
Attract – Creating a website. Write blog articles. Target companies and individuals with Facebook Ads.
Convert – Create a short page which shows a little about what you'd like to do for a specific company. Capture their email address and contact details at the bottom.
Close – Ping your phone/email whenever someone submits a form and follow up with pre-prepared content to answer their FAQs.
Delight – Respond to inquiries quickly. Move to set up a meeting. Get hired – then get results fast.
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Sign up and stay up-to-date with our latest content… There's a lot of awesomeness to come in this crazy year of 2020!


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Where have I been? Besides sewing up a storm, I have been knitting a lot of squares of late, a bit too boring to post pictures of until you put them together. My two friends and I have been making afghans for the volunteer organization we belong to. We all used to go to the weekly meetings and knit and chat with fellow volunteers, but we found that it was getting harder to attend the meetings due to some pretty full schedules of our own, so we decided to work on squares on our own time and then meet to assemble the afghan. The latest afghan was so much fun to put together! I actually created the color theme for the afghan so that I could knit the daisies for it. These are the smaller afghans designed for children. The larger ones are 39 squares which seems a bit daunting to us (two of us knit) so we leave the big ones to the group.
I am now working on the next one which is a Harry Potter theme. It's the Griffindor colors of maroon and gold. I'm hoping to add a Griffindor lion on one of the squares. I like the idea of doing the Harry Potter themes because they can be used by both girls and boys! At the moment, I am furiously knitting some I cords for little bags I'm making for my Etsy Store, Toadwerk and also hoping to complete "the other mitten" which will then become part of a nice winter set for myself. More soon!


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2013 Mothman Festival in 12th Year: September 21st-22nd, 2013
The Mothman Festival is celebrating it's 12th year. Come celebrate with us this year in Downtown Point Pleasant! We are planning some big things for the next decade of fun and weirdness. Don't know what the Mothman Festival is? Click below to find out more.
Mothman Festival Point Pleasant WVa.
Started by CaveRat2 , Sep 17 2013 07:55 AM
No replies to this topic
Posted 17 September 2013 - 07:55 AM
Visit my website, "The Paranormal DESTINATION"
Visit my website, "The Paranormal DESTINATION"
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Want to learn a new language? With this fun series of Hiragana alphabet sheets, you can start learning Japanese! Hiragana is one of the more basic forms of the Japanese writing system. Practice tracing the character, and learn a few new words.
Follow the link to see the whole Hiragana Alphabet Chart.


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Note: This review originally appeared in the Illinois Entertainer.
Finding a reverent version of "Edelweiss" from The Sound Of Music on Jane Lui's latest CD, Goodnight Company is a good indication that this is an indie rock artist who follows her own path. Lui's compositions are set to slow, spare arrangements that she occasionally embellishes with horns and string arrangements. Her poetic lyrics, which take an offbeat view of romantic relationships, are exquisitely rendered in a vocal style similar to Joni Mitchell's.
Lui captures the fun and adventure of a new love on the fetching "Jailcard" by declaring, "Tonight I got a ticket to a man." On the more bitter "Perished," she dismisses a lover with lines like, "Off you go with a foolish mouth" and "So take a bow and say goodbye." The acoustic "Illusionist Boy" is particularly reminiscent of Mitchell, while "Take Me For Now," with its ornate instrumentation, has more of a musical theater feel. "New Jersey" has Lui dabbling in R&B, and the CD closes with the stark but beautiful spoken word piece, "Last Rose Of Summer."