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TORONTO - Not all patient drug trials published in even the most prestigious of medical journals can be taken as gospel, say researchers, who have found a high proportion of "spin and bias" in the reporting of results.
Researchers at Princess Margaret Cancer Centre reviewed 164 breast cancer trials. They found that in studies that reported no real benefit of treatment, a large proportion focused on less important outcomes to give a more positive spin to results.
Of 92 trials that had negative primary outcomes, about 60 per cent used some secondary measures, "often trying to make the study look positive, though it really was not," said medical oncologist Dr. Ian Tannock, who led the study published this week in the Annals of Oncology.
"Sometimes studies that are basically negative studies are a little bit dressed up to look as though they may be positive," Tannock said Wednesday. "It's like the politicians. Trying to make things look better than they are."
The Toronto study focused on what's known as a trial's "abstract," the summary of how the research was done and its major results and side-effects. The key result is the "endpoint" — in this case, whether the drug in question did what it was supposed to do in patients or not.
The 164 studies appeared between 1995 and 2011, many of them in premier medical publications like the Journal of Clinical Oncology, Lancet Oncology and the New England Journal of Medicine. All were randomized control trials of at least 250 patients each, which typically tested a new drug or compared a new drug to an existing medication.
Tannock said some published reports of breast cancer treatment trials also downplayed or under-reported the incidence of toxic side-effects experienced by patients taking a drug being investigated.
In two-thirds of the reports, there was bias in the way adverse effects of the treatment were reported, with more serious side-effects poorly reported, the authors say. That was particularly true for trials that showed a significant benefit of a treatment.
"If there was an improvement in survival or time to the progression of the disease, they often omitted any statement about toxicity, even though in many cases there was a substantial increase in toxicity," Tannock said.
"And, of course, that's important because if you have a new treatment that on average improves survival for patients with metastatic (spreading) cancer by, say, three months and the treatments are fairly equivalent in terms of side-effects, that's an important advance.
"But if (a drug) improves survival but with a major increase in toxicity, I would say that was a very questionable advance."
The study also tried to determine whether misreporting was more likely if a trial was funded by the pharmaceutical company whose drug was being tested. But Tannock said "we didn't find that, at least not at a statistically significant level."
However, commercial sponsorship of trials isn't always disclosed in reports of results, he said.
Both pharmaceutical companies looking to sell new under-patent drugs — often with higher price tags than older off-patent generic agents — and researchers hoping for a successful trial outcome may both be at fault, he said.
"There is a subtle pressure on academic investigators to publish studies that will be noticed."
Tannock said it's critical that summaries of published clinical trials accurately report how efficacious a drug is in treating breast cancer, in this case, and laying out the severity of side-effects patients might have to endure with the treatment.
Often, the summary is all that busy doctors have time to read carefully, he said.
"Some physicians may be persuaded to use a new or different treatment than the standard because they have read papers that suggest that this is a better treatment when it may not really be a better treatment," he said.

subset: commoncrawl


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That was until I checked my email search engine, and found that copies had actually been forwarded to me before the project started. Oops.
Granted, the following doesn't include the online newspaper copies from the online archives, but it's still better than nothing, and you get the following in chronological order. I've posted several of these comics before, but they may make more sense in conjunction with the daily strips.
Orbit's shoeshine business was a running theme that occasionally popped up in the strip, and was strongest at the beginning when he was regulated to the post of a... shoeshine boy.
Bear with it. This is the last of bad puns for a while.
Pay attention to the reuse of a certain panel in this Sunday comic for a daily strip later.
Have you found the duplicate panel yet?
And that's where my collection runs out.
EDIT - a commentor pointed out that the link is still available on WebArchive, but most of the pictures are broken. Fortunately, the blog images they were posted to still work. Rather than go to the trouble of going to another mostly empty page, I'll save you the trouble & show the missing pictures. But before that, here's some fan art of the founder, Jason F. Talbert.
There was also an ad for submissions for a drawing contest for children. Most of these would take up space in the Sundays, rather than advance the story.
And now for the remainder missing comics:


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Jonathan Seib / Fort Morgan Times
Jonathan Seib / Fort Morgan Times
Jonathan Seib / Fort Morgan Times
Jonathan Seib / Fort Morgan Times
AIR FORCE ACADEMY – Coach Ken Garcia was beaming with pride as the Brush Beetdiggers finished up their 2013-14 campaign with a win in the 3A Consolation Championship game. Brush won 77-71 over the Moffat County Bulldogs.
"I am extremely proud of the kids. When you have aspirations, you know, of winning the state title and you lost that first game. And the team that we lost to is in the state championship, so that isn't a fluke or anything. But we had the composure and that senior leadership to say we still have games to play and lets step up," said coach Garcia.
And step up they did, enough to bring home a new trophy for the 2014 season.
"We wanted to show our fan base and the state of Colorado that we can play basketball. And we stepped it up last night and they were able to able to grind it out today to win. I appreciate and am proud of their effort, what a great year," said Garcia.
After the first half, it looked like Brush was well in control of the game. The Beetdiggers had a 12-point, 38-26 lead at the end of the first half. The Moffat County Bulldogs had other ideas.
After a couple minutes Brush still led by 46-37, but then the Bulldogs went on a big run with 12 points to take a 49-46 lead.
Brush would keep it close through the end of the quarter, but would not take the lead back, entering the fourth down 54-52.
The two teams would keep trading points until Austin Garcia would kick start a seven-point run for the Beetdiggers to take a 66-42 lead. Kyle Rosenbrock, Bryce Needens and Randy Baker would all score in that run.
The Bulldogs would take the lead back one last time, going up 68-66 until Baker would score with about two minutes left to tie it up. Then Needens, who had scored on just one free throw so far that day, would hit a pair from the charity stripe to give Brush a 70-68 lead.
Those were the first four points of a eight-point run which gave Brush the six-point lead with 30 seconds left. Brush would get a layup from Austin Garcia and another from the line by Needens in the final second to keep the Beetdiggers up.
Coach Garcia said that the seniors were key to that victory and being able to come back in the end.
"There is no doubt that our seniors have been though a lot and that leadership and that ability to step up in situations was key. When we got down we could have hung our heads and said 'Aw, we're done' but our kids stepped up and it was due to our senior leadership," said coach Garcia.
It was a senior that led the team in scoring for the championship win as Baker scored a season high 34 points. Austin Garcia would score 18 and Kyle Rosenbrock would score 12. Both are juniors. Geoffrey Dunker, a senior, scored nine points and Needens, also a senior, got them to 77 with four.
Rosenbrock also had a double-double and Dunker was one-point away as both pulled in 10 rebounds. The two also had four assists each and Rosenbrock led the team with five steals.
Brush would start the game strong with Austin Garcia hitting the opening bucket. Baker though would go on to score eight in the quarter as Brush would charge out to a 17-9 lead. In the second, Brush would stay in control, holding the Bulldogs to 15 points and scoring 21 to take the lead going into the half.
With the win under the belt, the Beetdiggers will start looking to next year. Right now they plan on enjoying the win for a little bit and honoring the seniors that meant so much. Those seniors are Baker, Dunker, Jake Brown, Ben Mickey, Jacob Nichols and Trae Cranson.
"We're going to enjoy this for a bit before we worry about next year. We had a good JV program. We have some players here off of our bench here which should be ready to step up and get some experience this summer time before we get ready for next year," finished Garcia.
Contact Times sports writer Jonathan Seib at 970-867-5651 ext. 228 or email@example.com


text:
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text:
Time: March 4, 2010 from 5pm to 7pm
Location: Red Morton Park, Redwood City
Street: 1120 Roosevelt Ave
City/Town: Redwood City, CA 94061
Website or Map: http://maps.google.com/maps?f…
Event Type: hit, around
Organized By: Chris
Latest Activity: Feb 28, 2010
Export to Outlook or iCal (.ics)
Everyone is welcome. Come out and play.
© 2020 Created by Mark / The Mayor. Powered by


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Be stars are monitored spectroscopically (overwhelmingly at H-alpha) by amateurs probably more than any other group of variable stars, but there has been little virtually simultaneous photometric and spectroscopic monitoring of these stars done by amateurs. That's a fertile, pretty much wide-open field for amateurs, much as eclipsing binaries were 50 years ago. It also provides opportunities for collaborative programs amongst amateur photometrists and spectroscopists, as well as for pro-am co-operation. Here's a link to an interesting paper that points up the need for simultaneous photometry and spectroscopy of Be stars, and the science that can come from those observations:
The Correlation Between H-alpha Emission and Visual Magnitude During Long-Term Variations in Classical Be Stars
T. A. A. Sigut and P. Patel
Department of Physics and Astronomy, The University of Western Ontario, London, Ontario, CANADA N6A 3K7
H-alpha equivalent widths and UBV magnitudes are calculated for Be star disk models that grow in size and/or density with time. We show that these simple models are consistent with the known Be star classes of positive and inverse correlations between long-term variations in H-alpha and V magnitude as identified by Harmenac. We support the conclusion of Harmenac that the distinction is controlled by the inclination of the disk to the line of sight. We demonstrate that the strength of these correlations, particularly those of an inverse correlation where the system becomes fainter as the H-alpha emission strength grows, is strongly influenced by the scale height of the inner Be star disk and the extent of the gravitational darkening of the central B star due to rapid rotation. This dependence may allow coordinated spectroscopic and photometric observations to better constrain these poorly known Be star parameters.
Accepted by The Astrophysical Journal
Preprints from: email@example.com
or on the web at: arXiv:1301.3721
The "Visual Magnitude" in the title refers to V-filtered photometry, but long-term visual monitoring of Be stars is equally important as, similar to CVs or symbiotics, can go into "outburst" on a more or less regular basis, depending on the star.
Thom Gandet (GTN)


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The Indian Expedition is back in the UK. Richard rang me a few moments ago.
Of course, the most important thing that I wanted to find out was how Chris Clark is. The answer is thankfully pretty good. He was treated in India and managed to do most of the stuff that the other expedition members did.
The expedition appears to have been remarkably succesful. They have interviewed a number of mande burung eyewitnesses, photographed what appear to be footprints, and have obtained samples. One of these is a fragment of bone from the femur of what appears to be a bipedal creature, but until we have test results I would caution against getting one's hopes up.
They also have evidence for two other cryptozoological creatures. Richard gave me brief details, but he will be coming up here next week, and I will post further details then.
In the meantime it is just good to know that once again they have returned safe and sound.


text:
|$420.00 /
Oversized crew-neck t-shirt in soft cotton jersey with tekst print.
- The model wears size S
- Model sizes: Height 180 Chest 80 Waist 59 Hips 89 cm
Made in Portugal
We ship all orders with UPS. Orders are processed and carefully packed within a working day. When your order is ready for shipment, you receive the tracking details in your e-mail.
Pre-orders are shipped as soon as the product arrives in our office. All details can be found in our Shipping policy.
You can return any ordered product within 14 days of delivery, free of charge.
Select the order in your Order History, and create a new return.
For more information, please read our Return Policy.


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Every year, there's at least one summer movie that has a bizarre fast-food tie in — usually a weirdly themed Slurpee-style frozen drink. This year, my vote goes to Baskin Robbins, which just rolled out an assortment of Men in Black III-themed frozen treats, including the above "lunar cheesecake." Something about the extreme greenness of it is a bit... offputting. But it may be really tasty. Apparently, it was first introduced in 1969 for the Moon landings, and they're bringing it back for this movie.
There's also this Pink Surprise Cake, which apparently is based on a major plot point in the film:
And then there's the Spacey Sundae, which is sadly not named after Kevin Spacey:
Also, according to a separate press release, sister company Dunkin Donuts is rolling out the "Undercover Black Cocoa Donut, a star-shaped yeast donut filled with brownie batter butter creme and topped with chocolate icing and star sprinkles." And the Chocolate Lunarmax Donut, "a glazed chocolate cake donut with rich chocolate icing drizzle and star sprinkles." Actually, that last item sounds pretty tasty.


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Vega completes mechanical system tests
Europe's new Vega small launcher has taken the next step towards its maiden flight later this year with completion of mechanical testing of a full-scale mock-up at Europe's Spaceport in French Guiana.
One particular test showed that the vehicle and the pad structure can withstand high winds during the hours before launch.
Wind blowing on the launcher generates vortices at the back of the vehicle's body, causing vibration as they are shed alternately on either side. If the vibration frequency matches the structure's resonance frequency, then the movement can become dangerously self-sustaining. The results showed excellent performance from the launch system.
Other important work included Vega ventilation and thermal testing, inertial platform alignment and performance testing, and umbilical disconnection tests.
During thermal testing, the temperature of the vehicle, in particular the fairing and avionics, was monitored. The vehicle was exposed to the external environment to check the effectiveness of the design, both in normal and degraded conditions.
These tests were performed during daytime and night time to cover both launch situations.
A dry-run of the final countdown tested launch operations and the rollout of the mobile gantry.
Launch system tests continue
The mechanical and electrical interfaces between the vehicle and the ground segment are now being tested.
The operational procedures for integrating the launcher are being validated, along with its checkout, the loading of liquid propellants and the final preparation and readiness for countdown.
The electrical campaign is verifying avionics and software for the ground segment and the launcher equipment. Most of the automatic procedures to control and monitor the launch system have now been validated. The procedures for the countdown and specific Vega avionics, such as the thrust vector control system, are next in line.
On the mechanical side, the next job is verifying procedures where specific components and equipment need to be replaced when Vega is fully integrated in the mobile gantry.
Fluid tests are also being prepared. The AVUM restartable fourth stage will be filled with real propellant, which will finally validate the readiness of all launcher and ground segment procedures.
In the coming months, the Flight Readiness Review will give the final green light for the maiden qualification flight, in the second half of 2011.
This flight will be followed by five missions to demonstrate the system's flexibility.


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Lowest Price: £62.00The Canon Powershot S95 features a front control ring around the lens, pop-up flash, RAW support, image stabilisation, f/2 lens, tracking AF, and ISO3200.
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Word cloud t-shirt | Positive words that start with PSoft and lightweight t-shirt, with the right amount of stretch. It's comfortable and flattering for both men and women.
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Last Updated: December 31, 2019
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text:
Welcome to RedWolf Airsoft,
You've been selected to try the beta version of our new online store.
Would you like to try our completely new experience?
Marushin from Japan has a long history of quite interesting airsoft models as well as PFC (Plug Fire Cartridge) models, aka. model guns or cap guns. While they have the obvious M9 and 1911 models in their selection, they were never afraid to try something different. This goes for both the models they selected to replicate, but in this case also the operating method.
Shell ejecting gas blowback is a combination many have deemed impossible to achieve in a pistol, but Marushin managed to pull it off over a decade ago! How is this possible? A brief explanation is in order: The BBs are loaded into shells, which are loaded into a realistically sized magazine. No room for gas in there as well, so Marushin has made the entire back of the grip into a gas tank! It is filled from the heel of the grip, and you can actually feel it cool down if you shoot rapidly.
When you first pull the trigger, the hammer falls and strikes the valve to route gas behind the BB. The BB is shot out, and if you "feathered" the trigger, the slide won't move. Pulling the trigger completely actuates another valve, which routes the gas into the blowback chamber. Because a loading nozzle would not have time to move back to feed a full length cartridge if it was placed into the rear of the slide, the entire GBB system has been moved into the front of the slide below the barrel. As the pistol needs a recoil spring as well, it is placed around the outer barrel instead. Some real pistols have recoil springs around the barrel so it's not a completely unusual design, but the real CZ-75 has a regular spring and spring guide below the barrel.
A pistol of limited capacity that spits out shells every time you shoot isn't really the choice of a skirmisher, but the Marushin CZ-75 is not a complete joke in the performance department - of course considering the age. It shoots 0.2 gram BBs at around 200 fps with HFC134a, and is capable of putting shots into a palm-sized grouping from 5 meters. The slide action is surprisingly swift with a strong recoil spring, but the felt recoil is nothing to write home about because of light moving parts and the use of HFC134a. This pistol has no hop-up whatsoever, but the rear sight is quite high to extend the range by slight arcing of the BBs. (We wonder if the lack of hop-up on early models is the reason why Marushin puts two (sic) of them in their current models...)
They don't make them like they used to... No wait! In the summer of 2008 Marushin did announce that they are releasing another shell-ejecting GBB pistol, the Glock 21. The CZ-75 was a collector's item already 10 years ago, but perhaps there is a chance that these things are revived with new technology! And if you're into CZ's, you may want to jump on the few KSC models we still have left while they last.
Please see our demo video below:


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text:
Poisoned Property
This story appears in the March 2000 issue of Entrepreneur. Subscribe »
Toxic waste, heavy metals, Super fund sites . . . these all have to do with old mines and abandoned factories, right? Not necessarily. When you buy property for your business, it's a sure bet that someone else owned it before you, and someone else before that. Maybe it was a dry cleaner who routinely poured used solvent down the drain and out into an underground leaching field. Maybe it was a farmer who disposed of almost--but not quite-- empty pesticide barrels by tossing them into the ravine. Maybe it was a skeet-shooting resort with lead shots peppering the ground and poisoning wild geese. When your property turns out to be contaminated, it's your legal responsibility to pay for the cleanup--even if your business had nothing to do with creating the problem.
That's because of the federal Comprehensive Environmental Response, Compensation and Liability Act, better known as CERCLA, or the Superfund law. This 20-year-old law holds property owners responsible for the cost of cleaning up environmental contamination found on their property. Typically, the state or federal agency discovering the problem seeks to recover the cost of cleanup from the party who's easiest to find: the current owner. Then it's up to that owner to track down whoever was responsible for the contamination and sue for compensation. (Given the thousands of convoluted Superfund lawsuits mired in the courts, it's obvious the ones "cleaning up" are the lawyers.)
The legal principle involved here is "joint and several liability." It means that any one of the parties involved can be held responsible for the entire cost. In the case of contaminated property, that could be the individual or business that created the problem in the first place, the property owner at the time of contamination, the current owner or even the lender who helped finance the purchase of the property. It's convenient for government agencies, but hardly fair to innocent landowners trying to run their businesses.
Why don't property owners just grit their teeth, pay the cost and get on with life? Because environmental cleanup is extremely expensive. Coping with a contaminated well, for instance, might involve removing all the contaminated soil and paying to dispose of it, which could cost hundreds of thousands of dollars. Dealing with a major industrial dumpsite is even more costly. Accordingly, while industrial brownfields and toxic-waste sites must be cleaned up for the good of society, nobody wants to be the one who has to pay for it.
Congress is aware of the problems, but it has yet to forge a solution. Since 1992, Congress has been trying to agree on the necessary reforms to the Superfund law. Republicans are looking for major business-friendly revisions, while Democrats are hoping to address the problems by tinkering with the rules and regulations for enforcing the law rather than rewriting the law itself. The result is a stalemate that many expect to continue. If Congress does manage to reform the law, chances are it will provide specific protections for small businesses and local governments, encourage reuse of brownfields and protect recyclers who meet certain requirements.
Steven C. Bahls, Dean of Capital University Law School in Columbus, Ohio, teaches entrepreneurship law. Freelance writer Jane Easter Bahls specializes in business and legal topics.
Audit That Land
Until Congress changes the law, entrepreneurs are subject to the same rules on liability for contaminated property as major corporations. Even if the site was contaminated years before by some other owner, government agencies can still force you to pay the entire cost of remediation. As a result, if the land you buy is contaminated, it's important for you to be aware of it so you'll be able to walk away from the deal.
It's not always easy to tell. In some cases, there's an oil slick on a nearby creek or patches on a vacant lot where nothing will grow. People drinking water from a well near the property might become ill and start asking why. Typically, the city or county health department investigates such problems and reports its suspicions to the state EPA, which then orders the property owners to hire consultants and remediation crews. If the case is severe, the agency may hire a crew, then sue the owner for the cost of cleanup. It's often a battle of experts to decide the most suitable remedy.
Under current law, the only way for a property owner to get off the hook is the "innocent landowner defense." CERCLA excuses landowners who obtained the land after it was contaminated, but only if they inherited the land or did not know about or even suspect the contamination. It's not good enough just to have bought blind. In order to prove you didn't know about the problem, you must have undertaken "all appropriate inquiry" into prior owners and prior uses of the property.
That means you need to have an environmental audit before buying any commercial property. A Phase I environmental audit is a preliminary assessment by an environmental engineer or consultant, which involves looking over the property for evidence of contamination and examining the records of previous owners. A consultant who suspects problems would then recommend a Phase II assessment, which involves digging, drilling and testing samples. For a small retail site, a Phase I assessment may cost $1,000 to $2,000. For a factory site, it could run $10,000 or more.
Ask the seller if there's been an environmental audit, and ask to see the report. If not--or if you think you'd better have your own audit--look for a well-qualified consultant or engineer. Check references and ask to be put in touch with an attorney who's worked with the consultant.
Don't assume you can simply put a clause in the purchase contract stating that the seller assumes all responsibility for environmental contamination should it appear. Federal law does not allow buyers to escape liability that way.
If you're the one selling commercial property and you suspect it may be contaminated, don't ignore it. The old rule was "buyer beware," which meant it was the buyer's responsibility to discover any problems. In recent years, however, courts have ruled that sellers have to disclose information about contamination if they knew about it or should have known about it. So investigate and clean it up or at least inform the buyer. It can be difficult to sell property with environmental problems, but hiding them could be worse.
If there's a minor problem on your property, check with your state's EPA to see if there's a fund to help with the cost of cleanup. Most states have one, supported by a fuel shipment tax.
The problem of soil and water contamination will plague our nation for generations. Some major corporations are making inroads by knowingly buying abandoned industrial brownfields and rehabilitating them. Perhaps Congress will create laws to encourage such efforts and protect those who want to make the most of the land. In the meantime, be very careful when you buy property to make sure you don't buy an environmental disaster.


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Total Wine and More deal will is a big break for local company
For the two local men who make Siesta Key Rum, the truck that showed up this week to load several hundred boxes of their liquor was a very big deal.
Since starting in 2009, Drum Circle Distilling owners Troy Roberts and Tom Clarke have been working to get their handmade rum into more stores each year.
They have had moderate success, too, making inroads to all the Total Wine and More stores in Florida and select ABC Fine Wine & Spirits stores.
But with Wednesday's truckload, the distillery went national.
After the cases land in a New Jersey warehouse, Total Wine intends to ship them to its stores in 10 other states.
"This is a big step for us," Roberts said. "It's not very often that a small producer like us gets to go across the country with Total Wine."
Total Wine's decision to take the product national comes on the heels of another milestone for Drum Circle Distilling, whose three Siesta Key rum brands -- Siesta Key Gold, Silver and Spiced -- sell for $20 to $25 per bottle.
In November, Caribbean Journal magazine gave the Sarasota company's spiced rum the prize as the best on the market.
"This one wasn't even close," the magazine stated. "In a year that saw the debut of several new rums, and increased attention on the niche by the majors, a small-batch micro-distillery in Florida gets the Rummy."
"Using only natural spices and honey and no artificial flavors, Siesta Key, which is working to broaden its distribution across the U.S (and hopefully, someday, the Caribbean) returns spiced rums to the way it should be."
As artisanal distillers, the Sarasota entrepreneurs are part of a growing movement. In 2003, about 70 craft distillers were working in the U.S., according to the American Distilling Institute.
Ten years later, there are now 475, said Bill Owens, founder and president of the California-based trade group. Between 40 and 60 new micro-distillers debut each year.
"It's part of the food renaissance," Owens said. "People want quality things in their lives, and we are part of that. The wine, the beer, the coffee, the bread."
Drum Circle Distilling does everything but grow its own cane in an industrial building in southern Manatee County.
Along one wall are four 2,600-liter stainless steel tanks, for storing water, making mash and fermenting. The room also contains a large copper still, and dozens of heavy oak barrels mounted on racks.
Both men are involved in making the rum, though Clarke tends to focus on convincing retailers to carry the brands, while Roberts hovers more over the equipment.
While Drum Circle's owners decline to discuss sales or other numbers, their customer list is beefy, including dozens of independent liquor stores and many Publix Supermarkets in the region.
Still, the duo are not yet producing enough rum to hire help. That spooked Total Wine somewhat, but Roberts and Clarke reassured the chain that they could keep up with demand.
"We are designed to grow," said Roberts. "We know exactly what to do to double, or triple, production."