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Difference between revisions of "Talk:2011 Group 6 Project"
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==To do list==
==To do list==
Looking! :D
Looking! :D
Revision as of 21:32, 25 May 2011
- 1 To do list
- 2 Peer assessment comments
- 3 chat
- 4 to do list
- 5 to do list
- 6 Post Peer Assessment Discussion
- 7 Week 7
- 8 Week 6
- 9 By Week 5
- 10 Reference list
To do list
REGA!!! AMAZING!!! SO beautiful!! I love it! :)
Looking! :D
Jill, i just DONE the NMJ mech..... have a look...==[User:z3255968]]--Rega Tabbaa 21:20, 25 May 2011 (EST)
Thanks guys! looks great!! -Jill
Just show ur modification here, so we can see it and deceide...... I formed smthing but still reading till i come up with smthing good....User:z3255968 --Rega Tabbaa 21:12, 24 May 2011 (EST)
Thanks Jill!!Regarding the Mechanism of action part, I think leave the first sentence and just add a line after that, something like which involves neurons at the nerve ending, releasing of neurotransmitters and the receptors on muscle cell to respond to it...If it's ok with you guys I can change that paragraph :) --Shan Ruan 21:08, 24 May 2011 (EST)
Done the current research, tbls (bolding), embryonic (bolding)..... Thx Jill..The mech.of action has the paragraph and the steps, so r u OK with this girls?????? OR, should we think for some new sentences leading to the steps.....????--User:z3255968--Rega Tabbaa 18:41, 24 May 2011 (EST)
Done the referencing :) -Jill --Jill De Coster 09:47, 24 May 2011 (EST)
Hi Rega, sure, by highlighting u mean bold it? or actual highlight? or do u mean give a breif explanation on them or provide external links?--Shan Ruan 20:40, 22 May 2011 (EST)
I left only the mech of action with no change. Girls, we need only some sentences that dont repeat the steps. Headings and subbheadings DONE on thursday night... Shan, i want to highlight the agrin prot, musk,,,,,coz they r very imp prot for the nmj development..... Hey Lizzy, i couldnt let the paragraphs coz it was a repeat of points, so i done smthing new, added new things, and now it looks as a good text with some points to smooth the look of it......==User:z3255968--Rega Tabbaa 10:00, 22 May 2011 (EST)
Hi girls, I just added captions to all images I could find that were lacking. I also attempted a spellcheck with Microsoft Word but it stops at every single scientific term it doesn't recognize, which is all of them, so I gave up on that and just read through the page myself haha. I corrected the few misspellings I found. I think the headings &subheadings look good, and since we had such controversial remarks on dot points vs summary form, maybe it's best to keep both to please both audiences? Pretty sure we discussed this at the end of last lab but just throwing that out there again. Thanks for fixing those paragraphs Rega! -Lizzy 21/5
Lol Jill,,, also the ref for some componenets (Imp. struct.comp. tbl)...
Jill, i fixed and the part of Cellular organiztion of mm... Have a look because i added something abt the myofibril and sarcomere but i need ur help for the ref (the Histoly book and the Physio book). This section opens with the mm itself and evthing after goes smoothly with the proteins involved....==User:z3255968--Rega Tabbaa 15:30, 21 May 2011 (EST)
Ok, I fixed the ACh paragraphs and the rest. I think that the steps of NMJ's functions must stay as they are coz it's more clear. Anyway, if U guys want to change it feel free....==User:z3255968--Rega Tabbaa 14:35, 21 May 2011 (EST)
LOL Rega yes I was, I'm done now. You can edit away now~! :)--Shan Ruan 21:16, 19 May 2011 (EST)
Hey girls, i fixed the motor neurons and also the tble of the imp comp. Im still working on fixing but sometimes it doesnt save so ill try again... Shan r u working on the page??? I just saw u so ill wait till u finish.....==User:z3255968--Rega Tabbaa 20:23, 19 May 2011 (EST)
Revised to do list based on peer assessment comments:
- Spell and grammar check DONE
- History up until 2005 Done-added 2004 and 2005--Shan Ruan 20:10, 19 May 2011 (EST)
- Check all pictures are properly referenced and a link to the webpage that they came from.
- Revise headings and subheadings eg "historic researchers in NMJ" DONE
- Discuss page layout, should we move any sections? Maybe put microscopy at the end? DONE
- Discuss dot points for skeletal muscle etc. Some reviews loved it, some didnt. Keep as is? DONE
- Caption current research images so people know what they are looking at DONE
- Number mechanisms of action instead of dots as this is a sequence of events DONE
- Format current research, too hard to understand DONE
I think Ive covered most of the criticisms. Ive left out some conflicting criticisms where some people liked it and some people hated it, mostly these are related to too much information but im not deleting anything as we have worked too hard on it. Once you have done a dot point just put -done next to it so no-one else does it too. -Jill :)
Peer assessment comments
Group 6:
- Great hand drawn picture to start with to introduce your topic.
- Introduction is well outlined and informative.
- History is well presented and detailed but is there anything from 2004-present?
- Video is a very good idea to give a visual perspective of how this junction works.
- Overall very informative mechanism of action.
- Table of components needs some references.
- Not sure how benefits of light and electron microscopy and differences between scanning and transmission EM have to do with your junction but the explanation of those images of NMJ is very good and shows what it really looks like.
- Lots of effort and detail has been put into the muscle components and fibres but yet again I feel it strays a bit from the main focus of your page which should be the junction.
- Diseases table is great, pictures are interesting.
- For your external links maybe write a sentence next to each one saying what it is.
- For some of your pictures you have uploaded don't forget to put in the link to the website where you got it from. Also your picture for Botulism doesnt actually say the copyright permission.
- Hand drawn diagrams are awesome, great effort!
- Overall a great project, lots of research and effort to make a very informative, well structured and well outlined page.
Neuromuscular Junctions:
- Good intro, eases reader nicely into topic
- "Motor neuron" bullet points not best way to convey this information maybe. The info in the previous bullet point list is good but doesn't it just repeat what was said in the paragraph? try to consolidate the information.
- "Acetylcholine" bullet points confusing. what information are you trying to convey? are these the functions of ACh?
- I'm confused by a lot of the bullet points. Can you spell out what information you're going to say in the list before you list it?
- The stuff about microscopy, while interesting, seems unrelated to your topic
- Muscle cell organization seems beyond the scope of your topic, especially the stuff about ATP
- "Embryonic Development of the neuromuscular junction" good section, very informative.
- Nice disease table, conveys information really well.
- Well done current and associated research.
- Overall, very nice project, it was hard to come up with criticism. You have a lot of information that does not seem to be associated with NMJs. Take out some stuff that is too far away from your topic so that the page is more focused.
Group 6: Neuromuscular Junction
The page speaks for itself. I love the layout of the whole project. The content is diversified. It was easy for me to see and look
up the required information :) . I would suggest you to minimize the size of images, since some of them are quite big. Great use of table for the component.
I noticed in the Mechanism of Action: I found it a little confusing, because if they all belong to the same structure and in
order, I Would number them. ( i.e. 1) motor neuron, 2) ACh, 3) AChR's 4) Motor End plate.
It is well referenced and I find it hard to criticise the project page.
Overall, Marvellous piece of work.
GROUP 6: Neuromuscular Junction
This page was one of the pages that caught my attention as soon as I saw it and thus made me want to keep reading. The use of tables and dot points allows the information or the main points of the information to be portrayed through which is a good thing. The use of pictures as well also breaks the text up into smaller bits so it doesn't seem as if you are reading as much. There were some small spelling and grammatical errors but that's something a simple spell check will fix. I also enjoyed the small movie. All in all I didn't think there is much you need to change.
• Intro and history along with an expertly drawn diagram sets the page up very well.
• After reading I don't think anything to do with neuromuscular junctions has been left out, obviously a lot of work and research has been done here.
• The page was very easy to read and understand due to the use of point form and well placed pictures.
• Tables in the dysfunctions area is especially good.
• Only current associated research was what I found to be bulky and dense otherwise a perfect page to learn about the topic.
Group6- neuromuscular junction
- your project page in general is way over the top perfect
- everything is broken down into bullets making it so easy to digest
- the youtube video linked just took the page to a whole different level
- The huge hand-drawn image was very professionally done (gorgeous)
- The important strutural component table was very beautiful to read with a picture side by side
- The light and electron miscopy images are very apporpriate with the content
- The disorder section are just very indept – very professional
Overall i don't know what to mark down on this project page since everything seemed perfect to me :)
Group 6
The 1914 history note has a typo (warded should be awarded). The use of point form throughout the text is really good because it allows each important point to stick out. The History section is pretty informative but it ends in the year 2000. I think the addition of one or two recent history points would be a good addition to the page. The whole first paragraph in the Mechanism of Action section is missing referencing. The first sentence of the mechanism of action section is also confusing. The first paragraph under the Acetylcholine section is missing referencing. The YouTube videos throughout the project don't have any copyright information so perhaps this group should post whatever it is YouTube says about its content. The "Acetylcholine Nicotine" image in the AChR's section is missing referencing information. The use of a table in the Important Structural Component was a smart idea because it presents relevant information about the different components in a clear, organized manner. The image in the synaptic vesicles part of the table is lacking referencing information. The Ion gated channels and receptors part of the table has no referencing in it. The images in the postsynaptic membrane, Schwann cell, and Mitochondria parts of the table do not have referencing information. There is also no referencing information for any of the content written about Schwann Cells. I like how the group numbered the 3 principle ways in which muscle fibres form ATP. Beginning with the second sentence of the Embryonic Development of the NMJ section to the end of that paragraph there is no reference information. Although the content there is very informative, there should definitely be some referencing information to back it up. The "Human Embryo" picture lacks referencing information. The two pictures in the "Innervation of individual endplates" subsection lack copyright information. The two pictures in the "Presence of Multiple Endplates" subsection also lack copyright information. Furthermore, the text written in this subsection does not have any referencing. It isn't common knowledge that multiple endplates are present. The picture accompanying the Myasthenia Gravis disorder lacks referencing information. The image accompanying the Botulism disease has copyright information that does not necessarily allow the group to use the image. It says to ask for permission. The current associated research section was very well done because it had many pictures that related to the actual research that this section of the project discussed. For many of the referencing done for images throughout this project, the group simply lists the website. I am not sure if that is ok or not. This occurs for all images in the Current Associated Research section. Both the C elegans and the synaptic vesicle images in the Future Research section lack referencing.
Group 6
- A well written introduction.
- I like the short history section, but maybe add 1 or 2 more recent points.
- I liked the use of images, videos, tables and links.
- There are too many pictures close to each other in the future research section, so just some layout issues to be fixed.
- Other than that a VERY well done assignment, it was very informative and creative. Good job guys.
Neuromuscular junctions Pro6
- Nice layout, but seems a little overwhelming for the reader. A little more
restraint might be more effective, rather than a Tsunami.
- It is easy to feel the enthusiasm that the group has generated for the topic in every way and this should be applauded.
- What's the protocol with youtube referencing?
Who ever thought of youtube inclusions should get a pat on the back. I was immensely impressed. hats off.
- The synapse is a hugely researched subject
perhaps some assumptions can be made as to the general readerships scientific education and this might lead to a method for culling down the subject matter to not be so exhaustive.
- Outstanding use of colour and picture.
- For instance is it necessary to mention that light microscopes were invented around the 1600's? We are talking about neuromuscular junctions after all which shows that the reader
would be assumed to know of this, if not, that at least the instrument can view living subjects without too much damage/distress/mortality. My experience is that light microscopes used at university level are not cheap, ave price 2-5000$ AU.
- Current associated research seems too condensed.
- Overall the page has refreshed my understanding of the histological aspects of the subject, however there is not an even mix of the step by step informative approach, and the more advanced
aspects of the subject matter. I mean if the reader does not know basic microscopy facts then how are they going to manage MuSk signals etc? My point being that outstanding as the page looks how effective is it as a wikipedia teaching tool? A comprehensive editing process might decide on what level is this page going to plateau, and make it more in accordance with the stated purpose of the project.
Group 6:
There a a few spelling mistakes in your page, maybe just do a quick spell check
Need to complete history section, maybe up until 2005
Some pictures arent referenced eg embryonic development
Loved the videos
Good referencing
Good tables to break up text
The overall page is awesome, obviously a lot of hard work and research has gone in to it. Well done guys
Group 6: Neuromuscular junction
•Good introduction
•History anything beyond 2000?
•Perhaps remove "historic researchers in NMJ" its already under history subheading
•Video is really great idea
•For mechanism of action section can you maybe move a picture to the other left side to break up the text? It happens again latter down the page just something to think about before the final due date.
•Great use of tables and images helps to break up the text.
•Great integration of the microscopy section
•Interesting embryology research
•Clever input of potential future research with links
Group 6 Peer review
Introduction is brief and easy to understand.
History should be a little bit recent since it ends at 2000.
Mechanism of action part is mostly in dot point, less text but straight to the point and simple.
What I feel a little bit off-track is the part about advantages of light microscopy (LM) and electron microscopy (EM) utilization. I love the pictures and I feel they should be like in a gallery with a subheading "LM and EM images of Neuromuscular Junction (NMJ)". I just don't think the advantages and disadvantages of LM and EM are related with the NMJ.
I love the fact that you put in embryonic development of NMJ. It is so informative and shows that this is a result of a great research and for those who wants to know about how NMJ is developed, this is the page for them!
The images in common neuromuscular disorders are amazing and so eye-catching that you want to read the table!
Current and future research is very well researched with a good balance between text and image. There should be some captions under the images of current research though since they are graphs and fluorescence photos, it is hard to understand how these images are associated with what you have written.
Nice glossary and overall, this is a well researched page about NMJ. Great job guys!
Group 6
I was blown away with this project page. Not only is there a high level of detail, but it is presented in such a way that doesn't overload the reader.I particularly liked the EM section, it works well because of the balance of text to the pictures presented, and is very interesting. Perhaps the mechanisms of action should be numbered because it relays to a reader a sequence of events. Numbering what occurs would just reinforce this. Also, it could be handy to add some statistics to common nueromuscular junction disoders, to give an idea of how often these diseases occur. I know these seem like nit picking, but the page is so well done I could only suggest modifying some details. Well done.
Group 6
Good work guys! I really liked the video to describe the process. It really allows for a good understanding of the process! However for that section, rather than using the dotpoints, wouldn't it be better if you used a numbering system (to show the progression of the mechanism of action?) Also I think it would be good to discuss how muscle contraction occurs (i.e. following activation of the motor neuron, the signal transduction pathway that activates the muscle and causes the contraction). Otherwise, a job well done! :)
group 6
- The first thing that I notice is that the project is very long, and clearly very thorough. This is not a bad thing, given the number of tables and images which make it much more accessible.
- Youtube videos offer a different way of accessing the information, great idea!
- There is nothing negative to say about your project, it is clear that you have worked hard and it shows.
- You have put a lot of research into this assignment guys so firstly, well done.
- The first NMJ heading is a little unnecessary
- Introduction: Great
- History: Anything more since 2000? Also you don't need the "historic researchers in NMJ" title - it's implied by the subtitle.
- Mechanism of Action: Video is really great. There is a LOT of info here... is it necessary to go into so much detail about the motoneurons etc?
- Important Structural Component: The 'Important structural components of NMJ' heading should go next to table of contents it doesn't need so many titles. Great use of images though you need to include a link to their location from where they were found in the image's page.
- Light microscopy and EM pictures of NMJ: this section feels like it is just chucked into here. I don't think it belongs here but maybe with current research under research methods. It has great images though.
- Cellular organisation of skeletal muscle: Really well researched but i question the validity of the information here. I understand NMJ action Skeletal muscles but I think you may have gone off on a tangent and this information isn't very relevant to the topic at hand.
- Embryonic Development of NMJ: The idea of this topic is great. Awesome image though the article you explain goes into a lot more detail than necessary. I think a shorter, more succinct, summary would work just as well. Also you don't need as many images here, a caption would work better than more text and the images need copyright info and a link to the location that they came from.
- Common NMJ disorders: Don't need a title on top of the table the subheading explains it. Great images and table.
- Current Research: I got confused with the first sentence and what it was talking about. Was it in reference to the 2009 article bellow it??? Consider formatting this a little more clearly so it flows and doesn't just launch into topics. There may be a few too many images here... Maybe just one per article? Also add captions to the images so we know what they are just buy looking at them.
- Future Research: Really good.
- Glossary: Good.
Neuromuscular Junctions
- Good history, nicely detailed, but has there been anything since 2000? Surely there has.
- For the mechanism of action, I see what you've done with the dot points, but it could be even more effective as a sort of flow chart? That'd be really fantastic.
- A bit further down, I'm getting a bit confused with the format. I know we shouldn't be commenting on it, but how you've structured your information is a bit inconsistent. Ie the dot points. If you could compile it into a succinct paragraph? Or at least elaborate a bit more into the dot points. They are good in a lecture setting (where more information is provided vocally to "fill in the blanks") but I personally get confused without the complete sentences.
- None-the-less, you've got some great information there
- AWESOME table of components. Really good and helpful, especially with the addition of the pictures. I really liked that bit.
- Nice microscopy section, clever addition with some nice pictures.
- Some fantastic information in "skeletal muscle" section, but it's not entirely applicable to NMJs. Focus more on the NMJ involvement in contraction, as opposed to the details about the structure of actin and myosin etc.
- Interesting stuff about embryology, good work there
- Nice table for the abnormalities, lots of good stuff there
- The research area looks really good, and a clever input of potential future research
- Looks like a pretty good project!
-o wow, awesome screen sized intro image.
-it is so resourceful , details are well presented in an easy understandable way.
-I have no critics for you guys.The page stood out among others ,very great effort and well done !
Group 6: Neuromuscular Junctions
Introduction: The placement of the opening picture adjacent to the contents really engages the reader. Also, the actual introduction gives a good overview of what is to come.
History: This section is concise, however some of the entries could be cleared up such as, "At the Paris conference..." The conference does not seem to have been mentioned prior, so just some rewording or clarification would be helpful.
Mechanism Of Action: The dot points are good. Maybe to make the steps clearer, you could number them.
Structure: Breaking down the structural components in a table format really makes the information accessible.
Glossary: Potentially to make it an easier read, you could put the letters above their respective entries such as 'A' above the entries beginning with 'A'.
Note: The project format and content are very good. Just make sure to look over any spelling mistakes such as in the embryonic development section, 'The growing end of motor neuron axons secret...' when i think it should be 'secrete'.
Group 6
- Mechanism of action section well explained, but I'd probably put numbers instead of dot points to make it blatantly obvious that the steps occur in that order. The video is fantastic.
- The "motor neuron, "Acetylcholine (ACh)", etc subheadings were really helpful. I think making them into different segments really cemented the information, as oppossed to them being briefly described in a general section.
- Love your structural components table. You've probably realised that the table has two headings
- The photos in the microscopy section are really good. They help us actually visualise the NMJ and enhancing our understanding of schematic diagrams. I'm undecided as to whether or not the info on microscopy is irrelevant for this particular assignment, or whether it shows initiative...
- Embryonic section really interesting and unique- I haven't seen this sort of information on the other pages!
- Disease table is excellent. Really well linked to NMJ
- Great summaries of what are very complex studies in the current research section.
- Future research demonstrates that you have a great overall knowledge of NMJ research and as a result, can see where research is lacking.
- At first I was worried about how long the entire page is, but because it's well written and well divided, with useful pictures and graphs, it was actually very easy to read! Good one
I finilised the Intro,, everything is introduced for the reader,,, if u girls want to add other things,, pls feel free.. NOTE: add new stuff!!!! --User:z3255968--Rega Tabbaa 00:27, 12 May 2011 (EST)
Girls, the current researches section is done,,,,,If u all come early 2mrw morning we can add up things in Intro coz i run out of English words and i dont want to write in Greek language (coz i was nearly tu submit something written in greek)....haha --User:z3255968--Rega Tabbaa 23:25, 11 May 2011 (EST)
Happy bday Jill~!!!Thanks for the embryo pic, although it's not exactly cute~~lol --Shan Ruan 20:45, 11 May 2011 (EST)
totally serious haha! im going to kill them when i see them again! i had everyone calling me saying happy birthday lol. You are too kind to think of bringing flowers! xox see you tomorrow xox
No way,,,,r u serious??? hahaha,,,i was planning to get flowers 2mrw morning...
No problem Rega! Also, my physiology friends hacked my facebook and changed all of my details, its not my birthday today haha :) Thanks though :) xoxox i will add those references now xox
--User:z3255968--Rega Tabbaa 14:32, 11 May 2011 (EST) Happy Birthday to GORGEOUS JIll!!!!!! .... I saw the emryo pic and=stunning.... I know u r busy with ur birthday but a small help for ur poor friend (me=Rega),,,, the refs for the parts that dont have,,,coz i cant. For the ATP part in mm use the biochemistry book. Just add the ref in the end for each paragraph coz i did use my words... And u know how much i memoraised for the bioc test...(hahaha)... THANKU Jill,,xx
added a cool embryo pic in development :) check it out! -Jill
hey Rega! i was working on the page all last night, i think a few of us were on at the same time for a bit haha! im going to try and do the second youtube pic now :) -did it! :D -Jill
--User:z3255968--Rega Tabbaa 23:55, 10 May 2011 (EST) Jill, i left the last bit in current research for 2mrw coz i cant open my eyes anymore... The new design was just briliant (adding the pics in both sides), I loved it....thnkUUUUU
Lizz, we needed new text. It is the same thing written twice which doesn't make sense. I am fixing a lot of things, also Jill is adding new things to balance the dot points with text.... I was trying to take the refs and add them in ur paragraphs but doesn't work,,, so a new text with new ideas needed till thursday...If u come up with smthing just added...
Jill, r u working on the page....I just saw the utube pic....haha...--User:z3255968--Rega Tabbaa 22:46, 10 May 2011 (EST)
Oh nooo no no Rega, that's all I meant for the summary to be! I wasn't trying to take credit for your work, I'm sorry if you misinterpreted that way. I should have clarified that -- I didn't do any additional research, I just put what was already on the page in a different format because Professor Hill said the bullet points weren't okay. --Lizzy 21:59, 10 May 2011 (EST)
I saw it Shan, ThankU. OK girls, i added the ATP part in skeletal mm and there are two paragraphs now. I am trying to work on motor neuron but it doesn't save the work and ill try it later.... --User:z3255968--Rega Tabbaa 21:28, 10 May 2011 (EST)
Hi guys, I've just added another 5 points into the history area, including the one Mark Hill was talking about where synapse will still form in the presence of basal lamina but absence of myofiber. --Shan Ruan 20:38, 10 May 2011 (EST)
Hi Rega!! i only just read your message, can i meet you at WW at 11am? or anytime between 11 and 1? - Jill
Jill, i need ur help for the pics for current research section. 2mrw ill be early morning at WW. Each pic has a paragraph so it'll look good. I'll let for 2mrw to take off things that are repeated in mech.function coz doesn't make sense. For other points i did fix it by adding new text and letting some dot point.. eg, the structure is as follows,,,,..The developing part is good, and know with the pics is completed.. If u want to add the pics from the home just click the ref and choose what pic u want.... --User:z3255968--Rega Tabbaa 00:03, 10 May 2011 (EST)
--User:z3255968--Rega Tabbaa 22:21, 9 May 2011 (EST)
Hi guys,,,
Jill, i added things in SC, Mit, BL,, and ALSO fixing the the repetition that Lizzy done to my points. Lizzy, it is unfair to repeat me and say that u done the work. U should do things that are not mention at all such as function, current research, future research.... ANYWAY, girls i did put new text and the structure for some topics are still in dot points, and also ill stay for a long time 2night to work on other parts that need to be fix...
Jill you are amazing. Thanks! --Lizzy 17:48, 9 May 2011 (EST)
GUYS!!!! Ive manually changed ALL the pubmed references and referenced the page properly instead. The page now loads and saves STRAIGHT AWAY!! :D IM SO HAPPY!!!!! -Jill
hey guys, when you want to post something in this page, just edit that section, then it wont take ages to save :D
Hi Liz! I agree with your point about it being repetitive, but i think having both up helps people understand better. eg i read better in sentences, and others may read better in dot points. Lets leave it for now and see if anyone mentions it in the peer review :) Thanks heaps for doing that! Shan: did you add the section on development? Its really really good! i added it to the project page. i hope thats OK.
Yep I did, and thank u for adding it onto the project page, couldn't do that at home :) --Shan Ruan 11:41, 9 May 2011 (EST)
Im going to spend the next few hours to try to re reference as much as i can, so the page doesnt take so long to load each time. Hopefully it helps :) - Jill
Hi guys, I've added body to "current research, future research & history" and I've also done some editing & summarizing. When we last talked in class we agreed to keep the bullet points and summaries, but have a look, it sounds a little repetitive to have both. Should we eliminate one? --Elizabeth Bergman 21:10, 8 May 2011 (EST)
I've summarized most of the first half of our project page, and I'll be doing the rest of the weekend & adding it below the dot points like we discussed. I'm having some trouble uploading now but I'll keep trying. I've also added to current/future research --Elizabeth Bergman 20:09, 6 May 2011 (EST)
to do list
Hi guys, I've added body to "current research, future research & history" and I've also done some editing & summarizing. When we last talked in class we agreed to keep the bullet points and summaries, but have a look, it sounds a little repetitive to have both. Should we eliminate one? --Lizzy Bergman 21:10, 8 May 2011 (EST)
I've summarized most of the first half of our project page, and I'll be doing the rest of the weekend & adding it below the dot points like we discussed. I'm having some trouble uploading now but I'll keep trying. I've also added to current/future research --Lizzy Bergman 20:09, 6 May 2011 (EST)
-referencing. -done -Jill --z3265772 20:27, 9 May 2011 (EST)
-finish history i think we need to do more than this, either by adding more points or expanding the points at the bottom
-more on development I've done more on development as adviced by Rega.--Shan Ruan 16:47, 30 April 2011 (EST)
-current research -- I've added some body to this --Lizzy Bergman 21:10, 8 May 2011 (EST)
-future research -- I've also added to this. Someone added an article about Parkinson's disease that I'm not sure is properly referenced or relevant. I didn't want to delete it in case you wanted to use it elsewhere, but have a lookie --Lizzy Bergman 21:10, 8 May 2011 (EST)
-external links not essential, and ive added some anyway. Add more if you find some - Jill
-glossary- mostly finished this today --Jill De Coster 09:49, 29 April 2011 (EST)
-spell check entire page
-expand on dot points - mark mentioned dot points are insufficient to explain the process properly :(
-more on introduction
Hi all, apologies for my lack of contribution over mid semester break. I was travelling and had no access to internet. However I've been reading a few articles and I'll add further information where I can & build on what you all have already. It looks fantastic! Very cool videos you posted, Rega. Looking forward to seeing you all this week. --Lizzy 23:11, 2 May 2011 (EST)
Rega, i posted it for you, the stupid page is being very temperamental, sometimes i can save, sometimes i cant :( i might give up until next week because its taking up to much of my time --Jill De Coster 11:27, 29 April 2011 (EST)
Still, im trying to add and save the text and is not doing it... so, the text that i wanted to add in Current researches will be here till the pbl with the page will be fixed..I can't save anything on our page...
Neurexin in Embryonic Drosophila Neuromuscular Junctions (2010): In this study, Chen et al unfolded the role of the neurexin in Drosophila glutamate receptor abundance. Their results suggested that neurexin in embryos is present both pre and postsynaptically. Presynaptic neurexin promotes presynaptic active zone formation and neurotransmitter release, but along with postsynaptic neurexin, also suppresses formation of ectopic glutamate receptor clusters. During the research several methods were used. Starting with the hybridization where embryos were manually staged and dissected to examine neurexin expression. Dissections were performed as for confocal imaging and electrophysiology. For electron microscopy, genotyped Drosophila eggs were dechorionated with bleach. [1]
Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons (2009): Dupuis et al looked at abnormalities of the mitochondrial energy metabolism. Their findings proved that this defect is sufficient to generate motor neuron degeneration and suggest that therapeutic strategies targeted at muscle metabolism might prove useful for motor neuron diseases. Furthermore they suggested that muscle selective alterations in mitochondrial function might initiate NMJ pathology and participate in triggering motor neuron degeneration in ALS. Biochemical measurements were carried out followed by electromyography recordings and PCR analysis. [2]
Jill, i couldn't open the page 2-8pm, it's so slow now and i don't know why... I'll try to put some text to the current research not all... I want to see what Shan + Lizzy are doing or what they will??
What do u think about Schwann Cells, mitochondria and BL.... I think that they are important, they are components of NMJ.... How can i put 2 more rows in the first table?? I'v the material ready for it and the pics too.. Ok-have a nice break...--User:z3255968--Rega Tabbaa 21:36, 28 April 2011 (EST)
Did the glossary :) off to work now xox --Jill De Coster 15:59, 28 April 2011 (EST)
to do list
-referencing. -wait until next lab, no references will save
-finish history
-more on development I've done more on development as adviced by Rega. I can't edit the main project page at all, tried so many times, I think the server is down? So I'm just sticking the ref here for now.--Shan Ruan 16:47, 30 April 2011 (EST)
-current research
-future research
-external links
-glossary- mostly finished this today --Jill De Coster 09:49, 29 April 2011 (EST)
-spell check entire page
-expand on dot points - mark mentioned dot points are insufficient to explain the process properly :(
Hi Rega, im temporarily giving up on the page for today, ive spent a long time referencing but nothing will save. ive emailed Dr Hill and he says he is fixing it, so i think ill wait until tomorrow :) --Jill De Coster 14:28, 28 April 2011 (EST)
Jill, u mesmerized me with the microscopy section,,,,,JUST LOVED IT.... --User:z3255968--Rega Tabbaa 14:15, 28 April 2011 (EST)
Hey Rega!! LOVE the videos!! That was such a great idea to include them! i have added them to the page, so i dont think we need to add anything else for that section :) i am going to finish referencing today, and then maybe start future research. Do you like the microscopy section i added? :) - Jill --Jill De Coster 13:36, 28 April 2011 (EST)
Hi guys, there have been some problems saving stuff on the page, please please please dont edit the table under the heading Common neuromuscular junction disorders. i spent 6 HOURS trying to fix it! :O i never want to see that table again! haha :) Jill --Jill De Coster 13:15, 28 April 2011 (EST)
Jill watch this video about the sliding filament during mm contraction, watch the sarcomere.. [3]
Actin/Myosin Movie 1 [4]
Actin/Myosin Movie 2 [5]
If we put the Actin/Myosin both of above, we don't have to write how they work..
let me know what u think? --User:z3255968--Rega Tabbaa 20:03, 27 April 2011 (EST)
Hey Jill,,, im not going to upload my pic because urs is really good. Can we get rid of the other pic(troponin, myosin & tropomyosin)? About ur Q, I think that Dr Mark was more interested in cells that make NMJ. However, I'd the material ready for it and I thought was better not to uploaded. OR, maybe we can put a video for it.... Second, I put all my refs in the discussion page and if u remember i told u that we do it together, but u done it all. OMG, i know it takes so long to do the refs (i tried it with the history part)and THANK YOU. Organise one day next week and ill sit with u to give the final look of our page... --User:z3255968--Rega Tabbaa 19:43, 27 April 2011 (EST)
does anyone think we need to include excitation contraction coupling anywhere?--z3265772 14:41, 27 April 2011 (EST)
note to all: PLEASE reference anything you put up so people can see where you got your information, i have just spent two days trying to find where your information is from so i can reference it all :( --z3265772 10:52, 27 April 2011 (EST)
Rega: I think the clinical manifestation and treatment is pretty important, and it shows we have done more research. i have almost finished this section, and wanted to upload it today. The more we have on our page (that is relevant) the better, because it shows we have done more work. what do you think? if you still dont like it i will remove it, but i spent a lot of time yesterday researching these :( I think the muscle picture is a great idea, ive been trying to find a good one. if i find one i will upload it today and then see if you like it. I think reducing some text and having more in a picture is a perfect idea :) --z3265772 10:18, 27 April 2011 (EST)
--User:z3255968--Rega Tabbaa 01:41, 27 April 2011 (EST) Jill, i'm trying to draw a pic that includes and the sarcomere, so maybe we can get rid of some text and put a pic that talks about everything,, im still working on it. Let me know what u think..... The other thing is about the 2nd table. I think maybe we should not write about clin.manifestations and treatments,,, so the second table must enclude only three colons: the disease, the link with NMJ and the pic.... What do u think??
Thanks for doing the tropomyosin Rega! i thought i did it already, but it must not have have saved properly sorry --z3265772 22:26, 26 April 2011 (EST)
--User:z3255968--Rega Tabbaa 19:35, 26 April 2011 (EST) just wrote something about the tropomyosin. I love ur table Jill..
Jill, i liked it. Yesterday night, i really thought that a table or diagram will attract more eyes in looking at our page...Histology book had good pictures of BL and ill see what i can do... Don't 4get some dot points for the tropomyosin... --User:z3255968--Rega Tabbaa 18:44, 22 April 2011 (EST)
i have taken this out of the first table for now, until i can find a good picture and rewrite in lamens terms :)--z3265772 16:55, 22 April 2011 (EST)
|Basal lamina (BL) |Surrounds the Schwann cells of the axon and muscle fibre, Projects into folds that enclose the postsynaptic membrane |Layer of extracellular matrix, Synaptic cleft is filled with dense BL, Contain ACh-esterase, Lamina densa comprising the intermediate part of BL, procollagen type 4 is the most important component [6]
--User:z3255968--Rega Tabbaa 18:59, 21 April 2011 (EST)
Jill, i found this in uTube,, pls have a look..[7] I am adding some work that I've done for the cell components of NMJ.
--Shan Ruan 22:47, 20 April 2011 (EST) Hi guys, I've added some contents to the clinical manifestations for the table. One question though, should we use jargons like "ptosis" instead of "drooping eyelid" or the other way around to make the content more accessible?
--Lizzy 13:14, 20 April 2011 (EST)
Hi ladies, I've added a few images that could provide some visual material:
--User:z3255968--Rega Tabbaa 19:51, 16 April 2011 (EST)
I wrote something about the ALS-motor neuron disease.
Kumar, V., Abbas, A.K., Fausto, N., & Aster, J.C., (2010). Robbins and Cotran. Pathologic Basis of Disaese, eighth edition. Saunders Elsevier 2010.
Muscle Mitochondrial Uncoupling Dismantles Neuromuscular Junction and Triggers Distal Degeneration of Motor Neurons. This research explores that mitochondrial defect is sufficient to generate motor neuron degeneration. Furthermore, it suggests that therapeutic strategies targeted at muscle metabolism might prove useful for motor neuron diseases.[8]
--User:z3255968--Rega Tabbaa 14:48, 16 April 2011 (EST)
Hey guys, just wrote the introduction in the way how Dr Mark want it. This intro is not the final.
Development of NMJ
--Shan Ruan 01:01, 14 April 2011 (EST) Hey guys, just wrote sth for this section. Sorry I came back from a conference in Hobart just yesterday, thus didn't have much time to provide more input.
--Lizzy 19:22, 13 April 2011 (EST)
Pretty much finished up the table, just working on find an image for CMS. Found a bunch of great ones that are copyrighted. Boo. See you all in prac tomorrow!
awesome! Thanks Lizzy! --Jill De Coster 13:35, 11 April 2011 (EST)
--Lizzy 12:37, 11 April 2011 (EST)
Hello hello, I've added to the table on common disorders. Descriptions, treatments, and images for Botulism, CMS, and Myasthenia gravis.
--User:z3255968----Rega Tabbaa 19:46, 10 April 2011 (EST)
Motor End Plate
- Specialised region of the sarcolemma
- Highly folded
- Holds a high concentration of AChRs
- Also called Myoneural Junction (Junqueira C.L. & Caraneiro J., 2005. Basic Histology, text & atlas, 11th edition. McGraw-Hill Companies.)
- Receive neurotransmitters in order to propagate an Action Potential
- Responsible for the terminal tree like branching of a motor axon on a muscle fibre
- Maintains muscle tone through stretch reflex
--User:z3255968----Rega Tabbaa 14:23, 8 April 2011 (EST)
Motor neuron
- Efferent neurons
- Originate in the ventral horn of the spinal cord
- Synapse with muscle fibers
- Carry information from the central nervous system to muscles
- Facilitate muscle contraction
- Somatic once are directly involved in the contraction of skeletal muscles
- Excitatory
- Influenced by input descending from the brain
- Affected by a class of diseases known as motor neuron diseases
- Amyotrophic lateral sclerosis
Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS [9]
For Jill- neuromuscular junction disorders http://en.wikipedia.org/wiki/Myasthenia_gravis http://en.wikipedia.org/wiki/Lambert-Eaton_myasthenic_syndrome http://en.wikipedia.org/wiki/Botulinum_toxin http://en.wikipedia.org/wiki/Botulism and for an overview on all http://www.merckmanuals.com/home/ag/sec06/ch095/ch095c.html --z3265772 12:35, 8 April 2011 (EST)
ive uploaded a picture that Rega drew for the main picture, i think its a really good overview of our topic so ive put it at the top. Eventually as the page gets bigger, the contents menu will grow and the picture will fit the page properly (as in my embro project i did). Hope thats OK! we have four weeks until we need to have finished our page for peer review :) -Jill --z3265772 09:10, 8 April 2011 (EST)
--User:z3255968----Rega Tabbaa 06:56, 8 April 2011 (EST)
Group 6, now we have plenty of research articles and books in our hands, so start writing things down. Then we can link our writings together and design our page. Thank you Jill for helping me to upload the drawings.
Functional anatomy of the NMJ
- Nerve impulse reaches the motor nerve terminal
- Specialized proteins forming ion channels in its cell membrane open quickly
- Calcium enters into the axon terminal
- Synaptic vesicles are filled with ACh which is attached to special site of it
- Ca causes some of the vesicle membranes to fuse with the nerve terminal membrane
- ACh content is released into synaptic cleft
- ACh diffuses rapidly across the gap and binds to the ACh receptors (AChRs)
- When this binding occur, small positively charged sodium (Na) ions enter the muscle
- This lead to the depolarization across membrane
- End-plate potential in turn opens the voltage-sensitive Na channels at the synaptic fold
- An "all or nothing" action potential starts
- Propagated along the muscle fibre in each direction
- Initiation of a muscle contraction occur
- Then, the AChR pore closes
- ACh unbinds and broken down
--User:z3255968--Rega Tabbaa 20:39, 7 April 2011 (EST)
Synaptic cleft
- The space between the axon terminal and the motor end plate
- Separates the presynaptic from the post synaptic cells
- The electrical signal cannot cross
Synaptic vesicles
- Membranous organelle
- Contain neurotransmitter Acetylcholine (Ach)
- Found within the axon terminals of neuron
- Transmitter release occurs by fusion with the presynaptic membrane
- Ach is liberated by exocytosis into the synaptic cleft
Acetylcholine (ACh)
- Cholinergic neurons
- Skeletal muscle movement
- Regulation of smooth muscle
- One of the principle neurotransmitters of the peripheral nervous system
- Released by a motor neuron at the NMJ
- Bind and activate a receptor protein
- A very effective deliverer of sodium ions, which stimulate muscle contractions and excites nerves
- The enzyme acetycholinesterase (AChE) hydrolyzes acetylcholine into acetic acid and choline
- Choline travels back to be recycled into acetylcholine and start the process over again
- Concentration of ACh remains higher if the AChE is inhibited
- AChE inhibitors delay the degradation of acetylcholine
- This inhibitors are used to reverse muscle relaxants and sometimes to treat Alzheimer's disease
INTRODUCTION (anything regarding the introduction section of the project page goes under this heading pls!)
Just added a general description (will add reference later).--Shan Ruan 22:56, 6 April 2011 (EST)
Just an idea, as this page fills up with an endless amount of information, it takes ages to edit and save the page. To overcome this problem, just add a heading every now and again like i have done above, then we will just need to edit this heading, and the page saves quickly.
Also, we seem to be adding information to this page that could go straight on to our project page. We can always edit and refine later. I think it would be a much bigger job to eventually copy from this page on to our project page when we want to finish it. We will also lose alot of information if we do that because it will get lost on here. Maybe keep this page for chatting/adding relevant articles and if you have good info on something, add it straight on to the project. what do you guys think? --z3265772 22:22, 5 April 2011 (EST)
I think both are good ideas (about adding new headings and about contributing directly to the project page). It would be easier to delete info we don't need rather than semi-frantically add to it at the end. I'll start posting there more often. --Lizzy 18:14, 6 April 2011 (EST)
--z3265772 22:13, 5 April 2011 (EST) Hi guys, im going to kill two birds with one stone. i wanted to do this weeks exercise and fill in the relevant heading as i go. so i found some stuff for future research: http://www.ncbi.nlm.nih.gov/pubmed/20955113 it is about future stem cell research for neurodegenerative diseases. I added it straight on to the project page. For some reason i cant reference it though, so ill ask mark about that next week :)
--z3265772 22:13, 5 April 2011 (EST)
--z3255968 10:02, 5 April 2011 (EST)
Regas awesome drawing
Post Peer Assessment Discussion
Hey guys in response to the peers i moved around my pictures, gave them text under them, and added a lot of new information and some photos to the structure section. the only issue we have left is to clean up our reference list since it mostly looks like a bunch of pubmed IDs. i guess we will ask mark what to do with this.--Michael Orenstein 21:48, 25 May 2011 (EST)
Week 7
- This is the week before the mid-session break.
- In the lab this week we will have an opportunity to discuss any issues which are slowing progress on your project.
- The Thursday of the week beginning 02 May will be when all projects will be open to Peer Assessment.
- What you have on your page by Thursday of that week will be the content that others in the class will comment upon.
Week 6
- I see many groups now have subsection titles for their projects.
- Here are some searches: Pubmed search all databases junction | PLoS junction | JCB junction You can now simply put your own search term into each top window.
- Now's the time to get your images, movies, media etc uploaded. Biomed central | JCB | JCB Archive | PLoS. Once uploaded you can make a gallery on either your project or discussion page using <gallery>File:name here</gallery> tags with your image files listed between the tags. When you upload project images, add this text as it appears replacing # with your own Group number to the summary information [[Category:2011Project#]].
- Shown below are the criteria that will be used to assess your final project.
Group Assessment Criteria
- The key points relating to the topic that your group was allocated are clearly described.
- The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
- Content is correctly cited and referenced.
- The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
- Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
- Relates the topics and content of the Wiki entry to learning aims of cell biology.
- Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
- Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
- The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
- Develops and edits the wiki entries in accordance with this sites wiki guidelines.
By Week 5
Each Group member has added to the discussion page:
- A Review Article
- A Historic Research Article
- A Current Research Article
No two students should add the same paper and there should be a link to the original article.
--Mark Hill 17:18, 30 March 2011 (EST) OK Group 6, You and Group 5 are the only groups that have begun your project work, well done! Though I can only see contributions from Z3255968 and Z3265772. This search should get you started with the references Search Pubmed: Neuromuscular Junction
Hi Guys, Here are the articles I've found pretty useful to NMJ.--Shan Ruan 13:32, 5 April 2011 (EST)
- Review Article: Neuromuscular junction in health and disease This is a review article from the British Journal of Anaesthesia. It outlines the structure and function of the NMJ and (discusses the anaesthetic implications of disease of the junction)<- can ignore this part. Current concepts in neuromuscular transmission Outlines the general anatomy and physiology of NMJ. Both articles overall are very useful but you need to ask for permissions to reference them. However, since they are review articles, there should be plenty of articles down the reference lists.
- Historic Research Article: The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo This research article indicates the role of the receptor MuSK protein which responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for the formation of neuromuscular synapses.
- Current Research Article: The Function of Cortactin in the Clustering of Acetylcholine Receptors at the Vertebrate Neuromuscular Junction This research article suggested a novel function of phosphorylation-dependent cortactin signaling downstream from agrin/MuSK in facilitating AChR clustering at the developing NMJ.
- Hi guys, Lizzy here.
I've been surfing around Pubmed. Here's a recent article on the significance of the role of MRF4, a transcription factor that may be involved in maintenance of neuromuscular junctions: Maybe we could mention it briefly under "Current Research." Also, this article had some lovely images: However I'm not sure how relevant the article is, and I'm also not sure if we could get permission to use the images on our page. But maybe they'd be cool to have a look at on your own time. --Lizzy 16:46, 4 April 2011 (EST)
- P.S. Also, if you scroll down to the bottom of the PubMed Copyright notice page, there are 3 websites listed whose material we can use without special permission as long as we cite sources. Maybe they'd be handy for some neat images or background info.
PMC Copyright Notice --Lizzy 16:51, 4 April 2011 (EST)
- The three articles to be found by the end of Week 5:
- Review Article: On the development of the Vertebrate Neuromuscular Junction
- Historic Research Article: Change in the Fine Structure of the Neuromuscular Junction of the Frog Caused by Black Widow Spider Venom This was published in the JCB by Clark, Hurlbut & Mauro in 1972. It's a super interesting article! Heads up though, it's a big file.
- Current Research Article: ARIA, a neuromuscular junction neuregulin
--Lizzy 17:21, 4 April 2011 (EST)
--User:z3255968--Rega Tabbaa 20:54, 3 April 2011 (EST)
Group 6, this is a link for The Journal of Physiology [10]
There are some good research articles in NMJ.
Historic researches in NMJ:
In 1672, Myasthenia gravis (MG) was first described by Thomas Willis. It is an acquired autoimmune disease with antibodies against the nicotinic acetylcholine receptor (AChR) at the NMJ. [11]
In1842, Claude Bernard concluded that the arrow poison curare acts at the NMJ to interrupt the stimulation of muscle by nerve impulses. [12]
In 1850, Claude Bernard demonstrated that the observed paralysis was mediated via the NMJ, although the precise mechanism was at that time unknown. [13]
In 1914, Sir Henry Dale, (in 1936, he was warded the Nobel Prize for Medicine and Physiology), investigating the pharmacological properties of ACh, distinguished two actions that were reproduced by the alkaloids, muscarine and nicotine. As the effects of muscarine mimicked the parasympathetic nervous system, he termed the receptors muscarinic, whereas those in autonomic ganglia and at the skeletal NMJ were termed nicotinic. [14]
In 1952 - 1954, the name end-plate potential is used since Fatt&Katz (1952) and Del Castillom & Katz (1954) studied the endplate potential (epp) at NMJ. They concluded that the ACh molecules were released in packets containing several thousand ACh molecules revealing the quantal nature of synaptic transmission. [15]
--User:z3255968 12:31, 1 April 2011--Rega Tabbaa 12:38, 1 April 2011 (EST)
Abnormalities in signal transmission at the NMJ with associated diseases
This research explored that in skeletal muscle, the stability and function of NMJ depend on mitochondrial respiration. Furthermore, any abnormalities of this respiration lead to distal degeneration of motor neurons in Amyotrophic Lateral Sclerosis disease.[16]
This is a review article for the autoimmune disorders of the neuromuscular junction.[17]. The article unfolds the role of Acetylcholine receptors (AChR)and also the loss of AChRs at the NMJ is the underlying Myasthenia Gravis (MG)pathogenesis.However, if there is not enough ACh released at NMJ, it will lead to another disease such as The Lambert Eaton Myasthenic Syndrome.
Functional anatomy of the NMJ
All the behaviour depends on the ability to control the activity of skeletal muscles, which maintain posture and permit movement (Crossmen R.A. & Neary D., 2005). This group of muscles are innervated by axon motor neurons, the body of which lie in ventral horn of the spinal cord. The junction between the axon terminal of a motor neuron and the motor end plate of a muscle fibre make a Neuromuscular Junction (NMJ). When an action potential arrives at the axon terminal of a motor neuron, the voltage gated calcium (Ca)will open and through which Ca enters the cytosol. Then the acetylcholine is released which diffuses to and binds to cholinergic receptors at the motor end plate (Stanfield, L.C., & German, J.,W., 2009). This is followed by the opening of cation channels where the sodium enters the cell, producing an end plate potential. This cause an action potential which spread along skeletal muscle membrane stimulating contraction.
Historic background
Mechanism of action
Development of the neuromuscular junction
Common neuromuscular junction disorders
Current associated research
Future research
Hey guys, I've added a sub-heading of common disorders of neuromuscular junction--Shan Ruan 10:52, 31 March 2011 (EST)
--Rega Filipi Tabbaa 18:09, 29 March 2011--Rega Tabbaa 18:18, 29 March 2011 (EST)
Neuromuscular Junction (NMJ)
Embryonic development of NMJ
Functional anatomy of the NMJ
The role of Acetylcholine (ACh), its receptors and inhibitors
Abnormalities in signal transmission at the NMJ with associated diseases
Current research combined with techniques used
The actual wiki page for neuromuscular junction contains the headings - --Jill De Coster 08:09, 29 March 2011 (EST)
-Mechanism of action
-Development of the neuromuscular junction
-Knockout studies
-Neuromuscular block
-See also
-External links
-Further reading
Here is a link to my old Embryology page i did last semester, we should maybe look at a similar layout? --Jill De Coster 12:20, 24 March 2011 (EST)
1. Intro
2. historic background
3. current associated research
4. simplified description of technique
5. student drawn figure or animation
6. reference list
7. glossary
8. external links
example reference list --z3265772 12:21, 24 March 2011 (EST)
This is about frog nucleoli shape changes.


text:
And why do I punish myself by bothering to go over there and read threads?
Apparently his appalling spelling is because he was trying to catch a mouse……??
Join the club that I'll think you'll find the majority of Simmers belong to. You're not 'special' because you've been playing since TS1. In fact, it proves that you should know better.
"That is the joy of the internet, I don't have to act my real age because I don't care" – so you prefer to act like a 5 year old instead?
I think 'most' is meant to be 'mouse' so really there's no excuse for your poor spelling now, is there?
And why are YOU still replying? Oh yes, because you're a troll with NOTHING ELSE BETTER TO DO.
"I can be the exact opposite of who I am in person and never care about it" – something tells me that you're probably either not very nice in real life or in need of some kind of psychiatric help. Either way, your statement is most probably bollocks.
Why would you purposefully WANT to hurt and insult people? Oh yes, because you're a troll.
Aaah, so your parents are responsible for turning you into the thoroughly unpleasant person that you are. You're not capable, at the supposed age of 26/27, to work out for yourself how you should treat other people?
Whoopee-fucking-doo for you. You must be the ONLY Simmer who has their own house and car and degree. You seem to have such an inferiority complex that you find it necessary to tell everyone about your possessions and accomplishments. Sad fuck.
Meanwhile, Pary made me fall off my chair laughing:
Yawn….. Is it over yet?
Thank fuck for that. I have one question though – are you related to Rud3bwoy?

subset: commoncrawl


text:
Yet another day goes by that we're seeing some more Android 2.3 Gingerbread and Android 3.0 Honeycomb sightings. For those who have not been keeping up with this Android madness, Gingerbread will be version 2.3 of the Google mobile operating system, and Honeycomb will be version 3.0. Today, we're seeing some test builds of both of these OS versions floating around the web, signaling that Google is nearing completion of their next major Android OS update. Yeah, I know, we've said that one before, so who knows what this actually means.
The test builds were spotted using an app called AIRBench, which benchmarks the performance of Adobe Air on a handset, this one in particular being the Nexus One. The benchmarks show us that both Android 2.3 and 3.0 have been using the app, and hopefully are getting closer to a final release so we can stop speculating so much.
From what we've heard, Android 3.0 "Honeycomb" will be more tablet-friendly than any version of Android, where Gingerbread is still designated for smartphones. But if we're seeing the Nexus One running both versions of the OS then Honeycomb may make its way to smartphones after all, with it being able to support a better experience for tablets.
There were a couple of Honeycomb test builds (HRI783D, HRI83D) and one Gingerbread test build (GRH47B) found using the application, but does this mean that the builds will be released at the same time? And if so, will the Nexus One skip Gingerbread all together and get some Honeycomb loving? Probably not, but it's definitely interesting to see two different versions running on the same phone at the same time.
If the early December rumors are true, then hopefully we may see an announcement for Gingerbread and Honeycomb, but it looks like Honeycomb is slated to debut sometime in early 2011, leaving Gingerbread to rule the roost until then.
So, who's ready for Android versions like no other?
[UPDATE] We've been told that the Honeycomb sightings have been faked by the guys over at Frandroid to show just how easy it is to fake something like this by tweaking the build.prop. This means that even the Gingerbread sightings could have been faked, but were not by the Honeycomb fakers. Sorry to get your hopes up guys! Yeah, we know that's annoying, but the lesson here is to not believe everything you see.
[Via: Droid-Life, AndroidCentral] [Source: Air Benchmark]


text:
Summary and Keywords
Articulatory phonetics is concerned with the physical mechanisms involved in producing spoken language. A fundamental goal of articulatory phonetics is to relate linguistic representations to articulator movements in real time and the consequent acoustic output that makes speech a medium for information transfer. Understanding the overall process requires an appreciation of the aerodynamic conditions necessary for sound production and the way that the various parts of the chest, neck, and head are used to produce speech. One descriptive goal of articulatory phonetics is the efficient and consistent description of the key articulatory properties that distinguish sounds used contrastively in language. There is fairly strong consensus in the field about the inventory of terms needed to achieve this goal. Despite this common, segmental, perspective, speech production is essentially dynamic in nature. Much remains to be learned about how the articulators are coordinated for production of individual sounds and how they are coordinated to produce sounds in sequence. Cutting across all of these issues is the broader question of which aspects of speech production are due to properties of the physical mechanism and which are the result of the nature of linguistic representations. A diversity of approaches is used to try to tease apart the physical and the linguistic contributions to the articulatory fabric of speech sounds in the world's languages. A variety of instrumental techniques are currently available, and improvement in safe methods of tracking articulators in real time promises to soon bring major advances in our understanding of how speech is produced.
Keywords: speech, anatomy, gesture, coordination, coarticulation, phonetic implementation, articulatory phonology
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Make the best use of your limited time with precise, effective training. Track your ride with a Suunto GPS sports watch to see your current speed and distance, and connect it with your power meters* to get information about your effort when on the saddle.
On long rides you can get useful data about your training with 10 km/mi autolaps or by following your power data. Enrich your training with cycling-specific Suunto apps to get additional feedback such as hill gradient.
Check out how to use cycling apps
*Suunto Spartan and Ambit3 watches are compatible with BLE enabled power meters and Ambit2 with ANT+ enabled power meters.
Whatever your goal is, by analyzing your rides afterwards you can see if you're going in the right direction with your training. Suunto Movescount keeps you updated about your hours on bike, ride lengths and average cadence as well as your power and intensity.
Compare your speed and heart rate from different rides or follow up your power curve to track your hardest effort. If you have been riding those long hours in the mountains, you can check the altitude variations graph when cooling off at home.
Get the most out of your workouts and improve your fitness by planning your rides* in advance. Find the best training programs for cycling from Suunto Movescount, where you can connect with other cycling fanatics.
Suunto Movescount is also a great solution for your coach who can use Movescount to monitor your training and adjust your training program.
Check out training programs for cycling
*Applies to Suunto Ambit3 and Spartan families
Your Suunto GPS watch will inform you when you get stronger and faster on bike. Every time you ride your personal best 10 or 40 km/mi or hit your highest power, it's recorded on your Movescount account. If you have a competition coming up, you can go back to see if your pace or power has increased as planned.
Go to Suunto Movescount to see how other people are training and compare yourself to others to see how you are doing.
Suunto Bike Sensor is a great tool whether you're an enthusiastic road cyclist, an active indoor cyclist or a pro mountain biker. Use the Suunto Bike Sensor to maintain an optimum cadence while accurately tracking speed and distance.
The Suunto Bike Sensor is equally effective whether you are training indoors or biking in areas with a weak GPS signal. The easy-to-install sensor is compatible with sports watches and mobile apps that support Bluetooth Smart or ANT+.
Suunto Bike Sensor works best with Suunto Spartan collection watches, Ambit3 Peak and Ambit3 Sport.
With the Suunto Bike Adapter you can easily mount your sports watch to the handlebar of your bike. Quickly move your watch from your wrist to the bike so you can keep your eyes on the road and check your vitals with a quick glance down.
Suunto Bike Adapter is compatible with all Suunto watches.
Suunto watches are great tools for monitoring your cycling power by comparing your effort in real time with speed, distance and heart rate.
Review your training and track your performance in Suunto Movescount with useful data like your instant, average or maximum power per workout or lap. You can follow your trends over long periods or dig deep into a specific workout.
All Suunto Ambit3 and Spartan watches are compatible with Bluetooth power meters like Powertap power pedals, chain rings and hubs. Suunto Ambit2 watches are compatible with ANT+ power meters.
Suunto sports watches are compatible with Strava and TrainingPeaks.
Race segments in Strava and do deep analysis with Training Peaks. When synced with Suunto Movescount, any move recorded with GPS is transferred to your Strava and TrainingPeaks accounts automatically.
When heading for holiday or a cycling camp, the easiest way to plan your next day's rides is to use heatmaps. You can find the most challenging climb, best straight line for time trial or routes with the most amazing views by checking out the most popular tracks from Suunto Movescount.
See specific navigation features on product pages
Get inspired and learn more by reading cycling stories in Suunto blogRead more


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Here among the beautiful gorges and waterfalls of the Finger Lakes region of New York State is the city of Ithaca. To some it is considered an "enlightened" city, due to the influence of Ivy League academia and the many "open-minded" people who congregate here. Ithaca is a multicultural hub here in upstate New York, with many nations and cultures represented, as well as the many different facets that make up American culture. People of many different inclinations, orientations, and associations converge on this city, many looking for "enlightenment."
Within this "Melting Pot" there is a stirring in the hearts of a people. A people whose backgrounds are as diverse as the city that encompasses them, but who have been brought together to form a brand new culture. They have left their old cultures behind, with their many different flavors, to taste the culture that their Creator is forming in their midst. The stirring in their hearts is the desire to love as their Creator loves. Each one desires with all of their heart to see the Love of God expressed to all of creation, and is willing to pay the price to see it happen. This people lives together in true community, sharing all things in common, learning to love, serve, and forgive as a witness of the Creator's heart for mankind.
We here in the Community in Ithaca devote ourselves to our God and our Master Yahshua the Messiah and to one another. We practice our devotion day and night in order to demonstrate the life of peace and unity that the Son of God came to establish. We endeavor to show the care, warmth, and hospitality of our forefather Abraham. Though we fall short of our goal in many ways, we have hope to change. We, being only human, with our many failings and shortcomings, eagerly desire to properly represent the heart of our God.
We live in a large and beautiful house, which, much like our own lives, is in the process of restoration. Restoration is our Way in every aspect of our life. But it is happening, as we buzz like bees to make a suitable home for the many disciples who live here and for those to come. As our home and our lives are being restored, so the basic necessities of life continue. Here are meals being prepared and eaten together, clothing being sewn, places being cleaned, children being taught, and a livelihood being made. Because we love to be and work together, we have formed cottage industries. One of which is called the Mate Factor, where we prepare a tasty line of organic yerba mate tea. Our construction company, Commonwealth Construction, is where we extend our restoration and building abilities to those in the surrounding area.
The Twelve Tribes is a confederation of twelve self-governing tribes, composed of self-governing communities. We are disciples of the Son of God whose name in Hebrew is Yahshua. We follow the pattern of the early church in Acts 2:44 and 4:32, truly believing everything that is written in the Old and New Covenants of the Bible, and sharing all things in common.
E-mail us
Or call the phone number of your nearest community.


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Steve Ballmer is allegedly angry about the progress made up to the forthcoming Windows Mobile 7 OS.
At a recent Venture Capital Summit, where journalists are banned, participant Paul Jozefak Tweeted to say the head honcho wasn't happy:
"Ballmer says they screwed up with Windows Mobile. Wishes they had already launched Windows Mobile 7. They completely revamped the team."
He was also apparently unhappy about the way the whole thing was handled, with the whole episode not brought to fruition by the team working on the project at the start.
Pumping in talent
According to Twitter user Beninato, presumably also at the event, Ballmer said:
"Ballmer re: poor execution in Windows Mobile: "we've pumped in some new talent and said 'This will not happen again'"
Although not a lot is known about this new platform, it's anticipated that it will mark a renaissance for Microsoft in the mobile space, bringing better touchscreen support and more consumer oriented features.
Given Windows Mobile 6.5 hasn't even emerged yet (with the launch next week) it would make sense that a little more time would be given before Windows Mobile 7 appears in 2010 to allow the interim platform to gain a bit of traction and handset support.


text: « All Events This event has passed. U19 Academy Practice January 12 @ 1:00 pm - 2:30 pm Event Navigation « U17 Academy Practice U12 A N, U12 A S Boys Practice » Details Date: January 12 Time: 1:00 pm - 2:30 pm Arrival Time: 12:45 pm Event Group(s):U19 Boys Academy (2001/02) Event Type:Academy Practice Google Map: http://local.google.com/maps?q=University of Bridgeport,90 Linden Avenue,Bridgeport ,CT,06604,USA Coffee Nearby: http://local.google.com/maps?key=AIzaSyCFy0oVZfmkkisAjoEfrAR2rDTyrlqVpX4&q=Coffee ,Near 90 Linden Avenue,Bridgeport ,CT,06604,USA Venue University of Bridgeport 113 University Ave Bridgeport , CT 06604 United States Entrance Notes:Practice Entrance: 70 Linden Avenue, Bridgeport, CTrfor Games 100 University Ave, Bridgeport, CTrrFrom I 95 N take Exit 27. At end of ramp go straight and rr- for practices take 4th right on Broad St. Follow about .5 mile and then turn right on Linden Ave. Field is on right. rr- for games take 3rd right on Layette Street. Park in lot at north end of the field. rrFrom I 95 S take Exit 27 : staying left as ramp forks, turn south on Layette Street. Follow to end at University Avenue. For games, park in lot at north end of the field. For Practices turn left on University Ave, right on Broad Street, and right on Linden AvenuerrFrom Rte 8/25 South Take Exit 1. Turn Left on Prospect street and then 2nd right on Lafayette Street, under I-95, and proceed as above Arrive: 12:45 PM + Google Calendar+ iCal Export


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Flying Saucers are real… again.3:51 PM | December 22, 2017
I'll try not to be too long-winded about this. I'll save the in-depth, speculation and exchange for face-to-face encounters so you've been warned. I will discuss this with you… should we meet and you ask. Here's the briefest of recapsRead more
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Welcome to Flashback Friday, a weekly feature devoted to the 20th anniversary of the 1986 World Champion New York Mets.
Twenty years, 43 Fridays. This is one of them.
On a summer Sunday morning in 1986, I called Fred Bunz to tell him I'd be on my way over to pick him up for our trip to Shea Stadium. Fine with him, though he said his mother didn't understand why we were going to a Mets game. After all, it was going to be so crowded. I didn't cotton to that sort of thinking. If we want to avoid crowds, I said, we can just go to a minor league game.
"Or a Negro League game," said Fred.
And that, folks, was and, I suppose, is the essence of the wit and wisdom of Fred Bunz. He didn't quite get this whole baseball thing, or at least why exactly people like me were so heavily into it, but the beauty of Fred, among other things, is he was up for anything and could find something to say about it that nobody else could; semi-sequiturs, if you will. His mother, a sweet-natured German-born woman, hadn't raised a son who watched a lot of sports, so when Fred told her he was going to see the Mets with Greg and Larry, she didn't get it either. Why fight the crowds, especially when the games are on television?
Sure, I suggested. Let's just grill some hot dogs and watch TV.
Fred, deadpanning again: "And we can park at Waldbaum's and walk home."
Waldbaum's was pretty far from where we lived, see, and the Negro Leagues hadn't existed for…oh hell, I'm not going to explain it. I knew it was funny. If you knew Fred, you'd still be laughing, too.
In high school, I attempted to organize our newspaper staff into a softball team. Our coverage of the field didn't quite match our coverage of scholastic sports (which generally consisted of visiting one practice and doing one interview with one coach), so it was a tall order whipping us into shape. Feature page editor John Gillespie — ironically later an intramural softball demon at Boston University — bundled himself up in a parka and wool hat (I didn't wait for spring to start our drills) and chased a fly ball into centerfield. The fly ball won. Fred watched and, apropos of a dozen sportscasters he'd casually overheard, declared of John, "He's on his horse!"
We never actually played a game, but "he's on his horse!" remains in the record books.
There was seemingly no limit to what Fred knew at least a little about. He had finished his undergraduate work about the time the 1986 season got underway and was en route to a long program that would take him into a career of medical research. He was also a security guard at TSS, the department store in Oceanside that every family in Long Beach frequented when they needed anything at all. He was well-rounded that way.
But there was one thing Fred didn't know: That you could just buy tickets to a professional baseball game. Mets, Yankees, Minor League, Negro League; he confessed it was a mystery to him. But when I brought it up that hey, this is 1986, the Mets are great, we should go to a game…well, like I said, Fred was up for anything.
So, I suppose, was Larry Russo. Larry knew you could buy tickets to a baseball game. Approximately once a year since we were in high school, Larry and I would go to a game together, usually with Joel Lugo. Joel was my go-to guy where Mets games were concerned. He was pretty much the only serious Mets fan I was friends with through high school and into the years that followed college. I knew other serious Mets fans, but not well. I was friends with Mets sympathizers and empathizers, but not fans. It had been Joel and me for roughly a decade.
Joel and I made it to Shea twice in 1986. That's one less time than we did in 1982. It wasn't that we couldn't handle prosperity, it was that Joel either had to work days (regular hours at Chwatsky's of Oceanside, odd shifts at Shell Creek Park) or wanted to go out, drink and find women at night. What an odd priority for 1986. Somehow, Joel was scarcer than he should have been for baseball.
Larry didn't particularly care for the game, know a lot about it or offer up nifty bon mots in spite of it. If he had heard the "Negro Leagues" crack, I get the feeling he'd have innocently countered that if that's going to be less crowded, then maybe that's the game we should go to. I probably would have exploded in disbelieving indignation that he didn't know something I took for granted. Instead of wondering why Larry wasn't more interested in baseball, I probably should have been amazed he consented to one afternoon or evening a year of it with me and my stringent standards. But since we had a pretty good relationship that involved long discussions on the state of television and movies (he was a budding filmmaker) and life, I think he considered the annual Mets game kind of the cost of doing business with me.
Fred had said yes to August 3 against the Expos. Larry said OK, too. Joel? Chwatsky's or Shell Creek or Chivas the night before kept him at bay. We'd hook up with him later for Chinese food in Atlantic Beach. Hence, it was an unusual baseball threesome. Me and two of my closest friends from high school, neither of whom had given the slightest thought to Mookie, to Lenny, to even Doug Sisk.
I picked them up and, per Mrs. Bunz's forecast, parking was at a premium. We wound up in one of those lots more suitable to tennis than baseball. It was like three Waldbaum's away from Shea. I'm sure I tried to put a good face on it, but I don't think I was swaying my pals to the baseball fan's regimen. We trudged through marshes and meadows and asphalt and up those notorious escalators until we were in the upper deck, way the hell out in left field. A nice crisp view of nine dots in the field and one more dot at bat. Back in Long Beach, Fred's mother was probably clicking right by Channel 9.
It didn't rain but it looked like it might, so I brought my Mets cap umbrella. You opened it, it was an oversized blue cap with an orange NY. My mother found it at a Macy's in North Miami Beach. When the Mets scored — as they did early when Santana singled home Heep — I waved it. Fred, Larry and everybody in our section got a kick out of it. I'd have been on TV if we weren't twenty sections removed from all the cameras.
Bobby Ojeda took it from there. He retired the Expos inning in and inning out. Our section and presumably all others couldn't help but notice a no-hitter was in the works. Even Fred caught on; he knew baseball etiquette, however light he may have been on the particulars. Maybe Larry did, too, but as the tension mounted, he had wandered off to see if there was something on the premises more amusing than the game itself. Larry liked to wander around that way. Years in the future, I might do the same at a new ballpark and call it research. Larry, I determined then, was just being Larry.
Ojeda carried the no-hitter into the seventh. Could this be it? Even then, it was common knowledge that the Mets had never pitched a no-hitter. Four years earlier, Joel and I had watched Phil Niekro take one into the eighth here, but that was against us.
Alas, Luis Rivera, the Expos shortstop (making his Major League debut, no less) singled to right with one out in the seventh. Bobby O, who had been the Mets' best pitcher all year, got a tremendous ovation. We had been conditioned to give those when no-hitters went awry. With that bit of business done, the Expos scored in the seventh to tie it.
Never occurred to me that the Mets wouldn't win. And when Ray Knight doubled in two runs in the eighth, I brought out the umbrella and we cheered some more. Bobby started the ninth, but after getting the first batter, Montreal strung together three singles, the third of which, by Tim Raines, tied the score. A minute ago he had a no-hitter, now Ojeda was facing a loss.
But this was 1986. McDowell came in and got the Mets out of trouble. Larry returned to his seat for extra innings. In the bottom of the tenth, with two on and two out, Ray Knight stepped up. Most of the 47,167 who remained yelled and clapped and looked to unnerve Expos reliever Tim Burke. I say most, because one person somewhere in the stadium threw a paper airplane that was visible from where we sat. And Larry followed the path of the paper airplane. He was fascinated by it.
Knight singled, Backman scored, Shea shook and Larry asked, "What happened?" He was sore he missed the big moment, probably sorer that I pointed out he shouldn't have been watching the stupid paper airplane. Fred likely said something droll that got Larry even madder.
Airplane or no, those ten innings got Larry off the hook Sheawise for 1986. Fred didn't join me for any more games there either, but a week later when I said, real spur-of-the-momentlike, "Let's go to Philadelphia to see the Mets!" he said, "Sure!" He had never been to a ballgame in his life before August 3. On August 13, he'd be going to his second. Maybe he was falling for baseball or maybe it was just the undeniable appeal of "ROAD TRIP!" to two twentysomething guys working irregular schedules.
I had never been to Veterans Stadium. Despite it being in a major city on the other end of a major turnpike that connected to the major city we lived near, I got us a little lost on the way down, but we made it in plenty of time. Though there were plenty of fellow travelers from New York and a few highlights to speak of — notably Lee Mazzilli's first second-tour Mets home run — we lost 8-4. Fred, no more an expert on the Phillies than any other club, nevertheless managed to sum up the situation perfectly:
"Schmitty hit one out and the crowd went nuts."
There'd be a handful of ballpark trips with various combinations of Joel, Larry and Fred over the next several years, though never all at once. It took Joel's moving to Phoenix and Arizona getting a team and Joel having a family to lure each of us out there one weekend in 1999 to see the Mets play the Diamondbacks. By then, Fred had been living in Baltimore for quite a while, his passing youthful interest in baseball — the Yankees, alas — rekindled into a genuine appreciation for the sport by the opportunity to see games at Camden Yards. Larry was Larry as ever. His reception of baseball faded in and out like an AM station hundreds of miles away.
In the summer of 2006, however, Larry's antenna proved unusually sharp. He got the idea that the two of us should travel down to Baltimore to see the Orioles with Fred — "ROAD TRIP!" redux — even though he had never heard of Camden Yards or its landmark impact on ballpark design. Twenty years earlier I would have lectured him for obliviousness and we would've gotten into a pointless argument. Now? I calmly explained its retro essence and added, "I think you'll like it." He said he looked forward to it.
Luck put a day game on the schedule on a Wednesday afternoon when each of the three of us could make it. Fred, no longer baffled by the process, bought the tickets. We went, shvitzed, watched Barry Zito outpitch Kris Benson and chatted about everything and nothing. I thought about mentioning that this was practically the twentieth anniversary of that game in the upper deck with the Expos, the cap umbrella, the near no-no, the Negro Leagues, the Waldbaum's parking lot, the paper airplane and the missing of the walkoff hit, but I didn't. I get accused of remembering too many details as is.
Among the three of us, everybody has grown as a person since 1986. We are deeper, more experienced, have lived life as you might expect men in their forties would have. That said, it became abundantly clear that hot day in Baltimore a couple of weeks ago that none of us has really changed a damn bit. Fred stays Fred, Larry remains Larry, I'm me.
No complaints here.
Thanks in great part to this series of tubes known as the Internet, I'm fortunate to have lots of friends these days who are Mets fans. When I want to see the Mets play in person, I can find that kind of company rather easily, and that makes me mighty happy. But these friends of mine from high school? The ones who don't like awake juggling the 25-man roster in anticipation of October? Who wouldn't know Jose Valentin if his mustache tickled them on the subway? As little as I see them anymore and as little as they are interested in the only thing that seems to interest me on a going basis, I wouldn't trade their friendship for a dependable third starter, bullpen help and a lefty pinch-hitter…not even the reincarnation of Rusty Staub.
Fred and Larry, despite my putting them in front of the best team the franchise ever had to offer, aren't Mets fans. My failure to convert them has always disappointed me a touch, but they are my friends and always will be. They indulge or at least humor me when it comes to baseball and I manage to focus on whatever the hell it is they're talking about for minutes at a time when they bring up that stuff. After the game and a trip to the adjacent and surprisingly awesome sports museum in Baltimore, we went back to Fred's house, met his lovely girlfriend and the four of us went to dinner in their neighborhood. About halfway through, I realized the entire day had gone by and nobody had mentioned the godlike characteristics of David Wright — not even me. I have to admit it made me a little antsy to get back on the train to New York and go back to being my usual Mets-myopic self with my usual Mets-myopic crowd, but otherwise, it was as nice a Metsless day as I could imagine.
Tomorrow night, the Long Beach High School Class of 1981 holds its 25th-anniversary reunion. Fred (Class of '82) won't be there, but Joel is flying in from California. Larry was on the organizing committee, so I'll see him, too. I'm hoping he'll show the film he prepared for the 20th reunion. It was quite moving, his weaving of all the still photos and footage he culled of our class from when we were our younger selves. I think there was even a shot of me in my brand new Starter satin Mets warmup jacket.
Like I said, I haven't really changed a damn bit.


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I don't know about the rest of you, but that's the second time Steven Jackson has come around the edge against Hawk and Hawk should have had an angle to make the play pretty much a non-play but instead gave up 5-8 yards simply because he's not fast enough. He hasn't played horribly overall today, but I'm wondering if lack of speed may help explain why he's just not been worthy of the #5 overall pick.
AJ Hawk's 40-time may be over 5.0
2 Responses to "AJ Hawk's 40-time may be over 5.0"
DaveK Says:
September 27, 2009 at 4:06 pm |
I agree Andy and have thought for some time. He just looks a step slow all the time. He just looks to bulky up top and doesn't move well. I remember a story this summer where the trainers were trying to keep him out of the weight room as he is quite the workout warrior. I wonder if he needs to slim up and get some speed back.
56Coop Says:
September 28, 2009 at 10:08 am |
He also took some very bad angles on at least two plays that I saw.


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Kursus Online Bersertifikat di Indonesia The curriculum is a learning experience for students and KBM implementation guidelines for all parties in the school, so that students can progress to achieve educational goals.There is a relationship between curriculum with teaching, where the curriculum in the form of "what" is taught and interpreted as a way of teaching that is done by teachers to create learning experience on students.
Belanja di elevenia gratis voucher 1 juta In the curriculum, there are components that are interconnected. The existence of the target as a goal to be achieved, it is used as motivation. Then to achieve it, it is necessary to prepare the material or learning experience that has been set in the curriculum. So that the material does not deviate, need to be organized as well as possible to form a learning program. As for determining the success of an evaluation achievable goal.
The fundamental factor in the achievement of the curriculum is the teacher. Function curriculum for teachers is as a guideline prior to learning activities and work as a guide in organizing the student learning experience.
Maklon Kosmetik The curriculum serves as guidelines for the preparation of the book, while text books as one of learning resources to enrich the curriculum. Thus, it was concluded that the curriculum as a means to achieve the goal of education, while the textbook as a means of learning. Several factors are used as a basis to plan a curriculum that is the first principle of philosophy with respect to the system of values, views, and norms of a problem. Second, the psychological principles with regard to student learning and factors that hinder. Third, sociological principle with regard to the delivery of the curriculum in the community, whether it is appropriate or not terhadat demands of society. Finally, the principle of the organization with respect to the form of presentation of lesson material.
Synthesis Development – Developer Properti Indonesia Terbaik Things to note as the principles of curriculum development is the first principle of relevance and problem-solving that is arranged according to the needs of students live, so useful later. Second, the principle of effectiveness and is used as a driving motive in order to achieve the curriculum. Thirdly, the principle of efficiency and background that is utilizing everything that exists. Fourth, the principle of continuity which the material is delivered from the basic level and then progressed to a higher level. Fifth, the principle of flexibility and individual differences, namely the possibility of developing students to have another alternative to be able to serve individual differences. Furthermore, the principle of learning by doing is where individuals experience directly what he learned. Finally, the principle of finding intended that students can discover the facts of what he learned.
To realize the need to develop teaching. At the national level, the curriculum is developed with a centralized system. Regional level, local curriculum needs to be developed. School level, the program includes the development of quarterly, weekly, co-curricular, and extra-curricular. Grade level, such as the preparation of guidelines GBPP Lesson Unit. Undangan Pernikahan This section provides a detailed explanation of the structure of the Indonesian economy is now basing on macroeconomic indicators, progress and final performance.
The problems that occurred in curriculum innovation can be divided into four. First, the issue of the relevance of education related to the objective demands of the modern era. Second, the quality problems associated with increasing educational aspects in order to produce quality graduates. Furthermore, issues related to the efficiency of the business take advantage of opportunities in the education process. Lastly, the distribution of education is the member an opportunity to those who have not been educated with a decentralized system.
Curriculum development, to consider the structure of matter. The vertical relationship of teaching materials related to time. Horizontal relationship, ie teaching materials in the classroom relates among other subject matter. And, there are three criteria in the structure of matter, namely continuous, sequential, and integration.
Innovation in teaching and learning approaches can be done, among others, first learning experience a student activity in capturing and developing the material presented teachers. Second, active student learning that changes the position of the object learning students into studying subjects involving mental liveliness (like material), intellectual (thinking), and social (discussing the matter with a friend). And third, ie learning process of learning does not always have to memorize but how the process of receiving material.
Tas Murah The implementation of teaching and learning in the classroom can run optimally so need to be established first-class management. The concept of classroom management include independent learning, question and answer discussion, role playing, SD small, integrated schools, and SDLB.
Interior Rumah Teachers require innovation in the delivery of content. The delivery system can be done in two ways: the system modules and system learning package. Module system aims for students to learn independently and the teacher as a guide, so there is an opportunity for those in remote areas. The system aims to enable students to learn the package gets provision of useful skills for later life.
Later, innovation in learning evaluation assessment system is divided into six ways, namely non-paper test (non written test), the test in a reasonable condition (vote secretly), the test home test (in the form of homework / PR), performance (practice), portfolio (collection of tasks within a certain time), rubric (assessment using specific criteria based on the performance of learning).