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Types of cytoskeletal filaments
Introduction[✎ edit | edit source]
Although there are different types, all cellular cytoskeletons have thin, fibrous structures and are polymers of basic unit proteins. They have unique characteristics and perform various functions according to their nature.
The basic functions of the cytoskeleton are the formation of a structural shaping frame of the cell, the guidance in moving of the cell in its environment and of the cellular interior and furthermore the cell signalization.
The roles of the cytoskeleton can be organized in both structural and functional ones. The main structural roles of the filaments in a cell are the preservation of its shape and the organisation and arrangement of its various organelles. The functional roles are played through the interaction with other proteins, e.g. muscle contraction, cell locomotion, cell division and intracellular transport.
The three types of cytoskeletal filaments are:
- Microtubules
- Intermediate filaments
- Microfilaments (actin filaments)
Mechanical properties of individual types of cytoskeletal fibres
Microtubules:[✎ edit | edit source]
Microtubules can be found within the cytoplasm of all eukaryotic cells. They have a ring-shaped structure, with an (outer) diameter of 25 nm and vary in length. This type of cytoskeletal filaments is synthesised by the polymerization of a heterodimer of two globular proteins, the α and β tubulin.
Structure:[✎ edit | edit source]
Microtubule: 13 protofilaments protofilaments: polymer consisting of dimers of α and β tubulin
Polymerization: binding of GTP (GDP) + end, - end of microtubules
- dynamic instability
MTOC (microtubules organizing center)
- structure found in eukaryotic cells from which microtubules emerge
- two main functions:
- organization of eukaryotic flagella and cilia
- organization of the mitotic and meiotic spindle apparatus (which separate the chromosomes during cell division)
Function:[✎ edit | edit source]
Mitotic spindle: centrosomes
Flagella and cilia: structure (9 doublets +2) movement (motor protein dynein)
Tracks for the movement of organelles: motor proteins (molecular motors) dynein a kinesin
Intermediate filaments:[✎ edit | edit source]
Intermediate filaments can be found in the cytoskeleton of many eukaryotic cells. They have an average diameter of 10 nm, which is between the average diameter of the micro-/ actin filaments (7 nm) and that of the microtubules (25 nm). They are composed of various related proteins that share similar structures but that perform in different types of cells. More than 50 different proteins of intermediate filaments can be distinguished. Based on the heterogeneity of those proteins, the intermediate filaments that are formed consequently have been classified into six subgroups. The classification is based on identified similarities and differences between the varying amino acid sequences of the different proteins.
Type I and II[✎ edit | edit source]
These filaments are formed of two groups of acidic (I) and basic (II) cytokeratins (each consists of about 15 different proteins), which contribute to specific junctions between epithelial cells. In order to form a filament, each type of epithelial cells has to synthesize at least one type I and one type II, which then copolymerize. The keratins produce filaments that are, depending on their distinctive chemical and immunological properties, of basic importance for several diverging cellular functions. The evolution of keratins made living in a terrestrial ecosystem possible, e.g. due to a differentiation process of epidermal cells that resulted in a reduction of harmful dehydration. A disruption of the acidic cytokeratin can cause some blistering skin disease, a disruption of the basic cytokeratin can cause corneal dystrophy and keratoderma (abnormal thickening of the palms and soles).
Type III[✎ edit | edit source]
Type III includes various types of proteins that are found in different kinds of cells. The protein desmin contributes to muscle cells, vimentin is expressed in mesenchymal cells (white blood cells, fibroblasts and smooth muscle cells). Other specialised proteins of the type III are Synemin, which is also distributed in muscle cells, peripherin, which is expressed in neurons (especially of the peripheral nervous system) and the protein GFAP, which can be found in astrocytes (glial cells). A disruption of the protein desmin is involved in the development of myopathies.
Type IV[✎ edit | edit source]
This type includes the protein α-internexin, which is expressed at an early stage of the embryonic neuron development and the three neurofilament proteins NF-L, NF-M and NF-H, which play important roles in many types of mature neurons.
Type V[✎ edit | edit source]
The type V proteins, the nuclear lamins, are expressed in the nuclei of all eukaryotic cells. Their function and structure differ from those of the other intermediate filament proteins. If the protein lamins is disrupted in any way, it distributes to the development of cardiomyopathy, muscular dystrophies and infrequently the progeria syndrome (genetic disorder with symptoms of aging at very a young age)
Type VI[✎ edit | edit source]
Type VI of intermediate filament proteins includes the protein nestin, which is expressed in some stem and embryonic cells.
Microfilaments:[✎ edit | edit source]
The monomers of the microfilaments are composed of actin, which is why this type of cytoskeletal filament is also known as ´actin filaments´. Their average diameter is between 5-7 nm.
Structure:[✎ edit | edit source]
Fibres: polymers of actin
- The basic unit of actin filaments is a protein called G-actin (which has a similar structure to many organisms such as ameba, plants and humans).
Microfilaments: double-helix
- G-actin polymerizes to form actin filaments with a diameter of around 7 nm.
Polymerization: binding of ATP (ADP) + end, - end of microfilaments -Dynamic instability
- Since G-actin molecule has plus end and minus end, the polymerized filament also has plus end and minus end.
- G-actin has a binding site for ATP or ADP, and ATP bound G-actin molecules polymerize stably. However, after polymerization, when bound ATP is hydrolyzed into ADP, the polymer will become unstable and can easily depolymerize. After depolymerization, when ADP is replaced with ATP, G-actin molecules again become able to bind to actin filaments.
Function:[✎ edit | edit source]
- in cell processes, they are involved in the formation of the pseudopodia (processes) of moving cells and processes known as microvilli often found in usual cells
Cell cortex: structure and localization function
- lamellipodia, filopodia, pseudopodia: amoeboid locomotion of the cell
- when located directly below the plasma membrane; the actin filament is stabilized and tethers the membrane proteins by forming a network structure
Contractile ring: cytokinesis
- actin filaments are especially abundant in the contractile apparatus of muscle cells.
- contractile bundles: "muscles" of the cell
- associated with motor protein myosin
References:[✎ edit | edit source]
- ↑ Alberts B. et al.: Essential Cell Biology. Garland Science. New York and London, pp. 571-607, 2010.
- ↑ Anthony L. Meschler: Junqueiras Basic Histology Text & Atlas, 13th edition, McGrawHill Lange, ISBN 978-0-07-180798-2
- ↑ University of Tokyo: Life Science Textbook, Komaba Organization for Educational Excellence, pp. 109-123, 2010


text:
Sometimes life doesn't turn out the way you want it to be. Sometimes, it turns out better. So, don't be disappointed when you don't belong there. It is because you belong here.
Month: September 2012
Living is like Driving a Car
To live, does it hard? Does it easy? No one knows. It's really feels like driving a car. Does it hard to drive? It's up to you.
Living is driving a car. One can determine where the destination, which way to go, and which route to take. But no one can really predict how the traffic really is. Sometimes it is jammed, sometimes it isn't. Sometimes the route is cleared, sometimes it is diverted. Sometimes the road is smooth, sometimes it is jagged. Sometimes, you crashed (hopefully, you don't :)).
Just like life. One can choose what to do, what to be achieved, and how to live. Sometimes life is smooth, sometimes there is obstacle. Sometimes the path is clear, sometimes one has to change all of the plans. Sometimes one succeeds, sometimes one fails. Sometimes one falls, sometimes one stands up. Sometimes one is granted happiness, sometimes hardship befalls. Sometimes, you got painful memories.
However, the most important part of all:
"See the life through the windscreen, not the rear view mirror"

subset: commoncrawl


text:
Make A Match - Animal Habitat
This colorful and fun matching game for 1 to 3 participants provides children with an excellent introduction to animals and their habitats. Children simply match each animal to its home to complete the puzzle and learn about the animal habitat. Play cards are washable.
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Your satisfaction is our priority.
- Contains 12 pairs
Age: 0-3+ years


text:
I'm about to rant a little bit of something about my job. But because I am bound by the non-disclosure thing at Company X, I will have to do it metaphorically. Just for the intention of complying that, I'm gonna have to ask you to imagine that I'm a surgeon. A good one at that. My job is to cut people open like a pig, remove their organs and have them analyzed in detail. Once I get all that done, I will then have to put them back in and produce a thorough report on what the fuck went wrong. Simple.
Although I can do my job quite efficiently, some of the chores can be arduously time consuming… one of them is – removing an uterus. You see, removing an uterus is not as simple as removing batteries off a remote control or anything like that. An uterus is big, complex, sensitive and stinks like a bottle of motherfucking Chinese calligraphy ink. It is something that requires a tremendous amount of time to dismantle (first remove the pussy, then the ass, then the head, spinal cord, etc – you get the idea). Labor intensive kinda job.
Yesterday, I was given 3 ladies with uterus problems at 11am. The officer wanted me to get the ladies all stitched up by 2pm. I said "No way dude, that's impossible" – and I explained that I needed a minimum 1.5 hour for each uterus job. And that's about one of the best you can get from an underpaid surgeon like me – with the limited equipment (I was given only a wooden ladle) and all that.
Fast forward today, I got a pep talk from my boss, that some high flying idiot (I learned this phrase today) from another department has a concern on my work. He said my delay handicapped their productivity. When I asked what's the deal – I found out that the 3 ladies with uterus problems need to go back to work by the next day, and they were unable to because of my delay.
I protested like "What the fuck??? Can't they go on medical leave or something?? Or get a fucking replacement for them??". My boss then told me that the high flying idiot, being a stupid fuck he is, felt that it is much easier for me to speed up than to ask those ladies to get a medical leave (because their medical leave application process is quite complex, apparently, and they don't like replacements).
In response to that, I went like,
"Without a functioning uterus, do you think that going to work is the most important thing those ladies should worry about? If that is so, then they should be living with the uterus problems instead. Why bother come to me?".
Ridiculous, I know. It's like complaining yourself having a time management problem when you could have at least surfed less internet and shirked less, rather than hoping the planet revolves around the sun at a much slower pace.
My job can be fucking frustrating at times, and it's not even mine or my boss' fault. It's somebody else stupider that holds high position. That's what happens when you get people like this holding the rein of a certain important job function. Ma fa hai puki cheebye. I hope the high flying idiot gets a stroke tonight.


text:
Uova alla Piemontese (Piedmont Eggs)
May 24, 2012
A tavola non si invecchia ("You do not become old at a table with friends and family")
~Italian proverb
Aptly named, Piemonte derives from the Medieval Latin Pedemontium ("at the foot of the mountains"). Lying at the base of the Alps, Piemonte is bordered by France and Switzerland to the west and north, as well as Liguria, Valle d'Aosta and Lombardia to the east and south (and a sliver of Emilia Romagna).
Once home to Celtic-Ligurian tribes and later Gauls, it was absorbed by the Roman republic. After the fall though, it was invaded by the Burgundians, the Goths, Byzantines, Lombards, and Franks with incursions by the Magyars and Saracens. Piemonte was divided by warring feudal lords before the House of Savoy, whose holdings included Sicily and later Sardinia, consolidated and ruled the region for centuries. Later, the region became a French client republic, was even annexed by France, and then was again restored to the Kingdom of Sardinia-Piemonte. Finally, Piemonte became a springboard for Italy's unification (il Risorgimento) beginning in the mid 19th century, with Torino even briefly becoming the capital of Italy. By the end of World War I, the states and regions of the boot agglomerated into one single state of Italy. Given this cross pollination, little wonder that cuisine there reigns supreme. That is just the shortened skinny, so my apologies to valid historians.
A haven for gastronomes, and while decidedly Italian, Piemonte sidles up to and has historical bonds with France. So the region has a culinary culture tinged with and subtly influenced by Provence (and vice versa). Even occitan is the spoken language by a minority in the Cuneo and Torino valleys, and franco-provençal is also spoken by another minority in the alpine heights of Torino.
From rugged peaks to gentle sloping hills to plains, the cuisine conforms to seasonal changes and regional anatomies, confluences. The Po River collects the waters flowing from the semicircle of mountains (Alps and Apennines) which surround Piemonte on three sides. The fertile Po valley plain creates the dense rice paddies near Novara and Vercelli. Fruit orchards abound and garlic grows effortlessly here. The vines of bold, elegant reds such as Barolo and Barbaresco grace the region.
Piemonte is home to zabaione, panna cotta, bagna cauda, white truffles, agnolotti, snail and leek casserole, polenta, risotto, confections and artisanal chocolates, tajarin (egg yolk rich pasta) — just to name a few. Unlike southern Italy, tomatoes might as well not exist here.
Bra, a town and commune nestled near Torino, is home to the "slow food" movement, a response to the fast food revolution. Slow Food occupies the crossroads of ecology and gastronomy, ethics and pleasure. A way of eating and living, it is a grassroots organization with supporters around the globe. Slow Food was founded to counter the recent rise of the fast life, the exodus of local food heritage, and the dwindling enthusiasm for food — its origins, scents, flavors and textures. (You know that common, but bizarre tableau of shamelessly gobbling down a double quarter pounder with bacon and "cheese" with an order of large fries or two and a huge coke in hand while winding through noon traffic between appointments.)
The movement fosters food biodiversity, encourages local culture, develops nexuses between farmers and producers, opposes multinational agribusiness, educates about food, and organizes food events. It ponders and acts upon how food choices not only affect individuals and families, but the world overall. Such admirable work with nary a shred of sanctimony. Be grateful.
While universal in scope, there are local Slow Food chapters called convivia. Each convivium arranges functions ranging from simple dinners to visits with local farmers to conferences and courses promoting Slow Food's tenets. Other networks give a voice to small farmers, breeders and fishers whose approach is geared to the movement's principles of connecting community to the environment.
"Slow Food unites the pleasure of food with responsibility, sustainability and harmony with nature," proclaims Carlo Petrini, Slow Food founder and president. Once again, the food abides.
Seemed only à propos to salute the egg here — especially local, coop coddled ones. First, hardboiled eggs marinated in olive oil with garlic, herbs, and anchovies, followed by that sublime trifecta of mushrooms, cheese and eggs.
6 hardboiled eggs
2 C extra virgin olive oil
1/3 C fresh parsley leaves, finely chopped
1/3 C fresh rosemary leaves, finely chopped
1/3 C fresh sage leaves, finely chopped
8 plump, fresh garlic cloves, separated, peeled and minced
1 T balsamic vinegar
4 fine anchovy fillets, drained and chopped
2 C extra virgin olive oil
Place eggs in a heavy, medium sauce pan, and add enough cold water to cover by 2″ or so. Bring to a boil over high heat, uncovered. Immediately remove from heat, cover, and let stand for 12 minutes. Drain hot water off eggs and then carefully transfer eggs to a large bowl of ice water to halt the cooking process. Then dry thoroughly with a kitchen towel. Gently crack the eggs and peel under cool running water, taking care not to mar the white. Put the peeled hardboiled eggs in a bowl.
Whisk together the parsley, rosemary, sage, garlic, balsamic vinegar, and anchovies. Then, while whisking vigorously, slowly drizzle in the olive oil. Pour the emulsion over the eggs in a mason jar, close tightly and refrigerate overnight or for a day. To serve, cut eggs in half lengthwise, put an egg on each plate, spoon over some oil, and savor with crusty artisanal bread.
3 1/2 T unsalted butter
1 T extra virgin olive oil
1-2 plump, fresh garlic cloves, peeled and minced
1 bay leaf
1 1/2 C wild mushrooms or crimini, cleaned and thinly sliced
Pinch of sea salt
1/4 C dry white wine
1/2 C Fontina cheese, thinly sliced or grated
4 eggs
White wine vinegar
In a heavy skillet, add butter, olive oil, garlic and bay leaf over medium high heat. Once hot, remove the bay leaf, place the mushrooms, sauté over high heat, add salt, sprinkle with the wine and allow to evaporate. Spread about half of the cooked mushrooms into four ramekins and layer with a few thin slices of Fontina. Set aside the ramekins and the unused mushrooms and cheese for later.
Preheat oven to 400 F
Fill a large, heavy skillet deep enough to cover the eggs with water. Bring to a simmer, and add the white wine vinegar. Crack each egg into a shallow bowl or saucer to assure they are not broken. Then, using a slotted spoon, spin the boiling water into a sort of vortex. Once the water is spinning rapidly, gently drop the egg from the bowl in the center of the whirlpool, where it will spin around and coat the yolk in a ball of egg white. Cook until the eggs are barely set, about 2 minutes. Remove the eggs, draining well with a slotted spoon and dab the bottom with paper towels to dry.
Carefully put the poached eggs into the ramekins already partially filled with mushrooms and cheese and then add the remaining mushrooms and Fontina. Bake just until the cheese has melted and serve.


text:
Getting revved up for a Tuesday. Writing decks. In the zone.
Another off my "Future jams" .....will probably only do one or two more...I think 12 was a bit much to shoot for. At least I am closer to 500 now~
A great band making a strong comeback. New album is amazing! Check out their catalogue.
Looking forward to the new album! Watching them in Manchester in October, incidentally...
Fucking right! A new classic from the dance-punk band that killed dance-punk so it could live forever.


text:
I guess in my heart I know these things have a utility and must be built. I want to build the things I think the world needs before I die. I love it when people use my products. Even though I don't feel I've made something 'successful', I feel as if my making something increases my odds of being successful as long as I take away a lesson from every project. Via Why I keep building
The feeling of making something from your very own hand is very special. And when some uses it, the feeling gets even more emotional.
An user sends me an email, sharing why the app I made was useful to him, even it was just a simple email. I felt that I standing on top of the world.
Question? What is stopping you from building your stuff?


text:
There was an article today in Yahoo! Health regarding toddlers at the dentist. I took all my children around their first birthday to the dentist. Part of my decision was due to the lack of fluoride in the water in the town we live in. The dental technicians were wonderful. My kids got to watch cartoons while their teeth were examined and then later when they all got fluoride. My oldest boy, who had just turned 4, had two cavities (his two back molars cracked when he was in a taxi cab accident - it's in my book!). He had to have a big, scary shot of novacaine, which brought tears to my eyes, but not his, prior to the drilling. The dentist was very engaging and made him (& me) very comfortable during the entire procedure.
Below is an article from Yahoo! Health. It's very informative; however, the pulling of wisdom is questioned in the dental community. Here is the Mayo's Clinic take on the subject.
Tiny Tots in the Dentist's Chair Among Changes in Pediatric Dentistry
FRIDAY, May 18 (HealthDay News) -- If you've been to the dentist with your children recently, you may have noticed that things have changed since you were a kid.
Many dental offices are more kid-friendly these days, offering books and toys to pass the time in the waiting room and maybe even TV or videos to watch while they're getting dental work.
But, there have also been changes in the actual practice of children's dentistry. You probably never got dental sealants as a child, or had topical fluoride treatments. If you had your wisdom teeth removed, more than likely it was because they were causing a problem, but today those teeth may come out sooner to reduce the risk for complications.
Too see the full article click HERE.
Here are some chapters of my book:


text:
Over £16,500 profit 2016/17 season!
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Our Pro Tips are on a great run in 2019. Another 3/2 winner last night and a nice £150 Profit for those who back our tips for £1 a point. That takes us nicely to over £950 PROFIT for the month.
Today's EVENS PRO TREBLE is now LIVE.
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PSG (-1) v Guingamp
League leaders PSG welcome bottom of the table Guingamp in the league tonight. Thomas Tuchel's side are unbeaten in the league this season and have scored a massive 53 goals in just 18 league games this season. The table toppers also have a sturdy defence, conceding just 10 goals in the league. PSG have scored 2 or more goals in 11 of their matches and have kept 8 clean sheets, meaning their -1 handicap shouldn't be a problem. At the other end of the table, Guingamp have conceded a massive 36 goals in their 20 games, the most in the league. They have also scored the least amount of goals in the league, with just 16 goals all season. We expect PSG to win this one comfortably, by more than one goal.
Manchester United v Brighton
Manchester United seemed to have found their feet under Ole Gunnar Solskjaer and will be looking to continue their fine form as they take on Brighton at home today. United have won their last six games in all competitions and come in to this one on the back of a fine win away to Spurs last time out. Brighton, on the other hand have failed to win in six of their last seven Premier League outings and sit 13th in the table. The Seaguls have lost their last eight outings against last seasons top six and we expect the same outcome at Old Trafford this afternoon as United look to record their sixth consecutive Premier League win & get payback for the guls beating them in the earlier fixture.
SD Huesca v ATLETICO (+)
Second placed Atletico travel to bottom placed Huesca in the league this evening. Atletico are unbeaten in a massive 26 games in all competitions and we expect them to keep that run going with a win or draw tonight against a struggling Huesca side. Huesca have failed to win 17 of their 19 league matches this season and have the worst goal difference in the league conceding 36 goals in just 19 games and scoring just 17. Atletico are dangerous on the attack, scoring 27 goals so far this season. The men from Madrid have the strongest defence in the league as well, having conceded just 13 goals in their 19 league outings. We expect Atletico to win or draw this one comfortably against a Huesca side that look nailed on for relegation to La Liga 2.
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post by Horse Racing


text:
Website by ThierryD
Copyright 2010-2015
All rights reserved
Reproduction prohibited
Last update : 2020/09/05
Do not panic, there is no need for knowledge in electronics and computer to make and build the "Photographer Tools".
Read this tutorial, I give all the information to do it.
If you have any questions or problems during the implementation, they should be asked in the forum, in the
"Questions / Answers" section, in the bottom of the forum (in the left menu of the website, there is a link to the forum).
And the answers will be useful to other people. I do not answer questions by email.
To make the Photographer Tools, you must buy electronic components. I provide a PDF (components list.pdf),
a list of components to buy with all references (in the ZIP file, left menu of the site, "Download" link).
The file "component list.pdf" is composed of several columns: Designation (component name) Boutique (the seller's website),
reference of the component on the seller, the quantity that you order, the price and a comment column.
Caution ! If you want to order electronic components away from my seller E44 ,
resistors are sold per 10, so when I write in the quantity column is 2,
it means in another seller 2 x 10 so 20 resistors.
Some electronic components can be purchased on sites sales electronic components online on the Internet.
I chose the E44 website ( http://www.E44.com ) to give you all references and price.
This online website selling electronic components,do postage delivery throughout France for 5 Euros (shipping costs).
They can also make deliveries in Europe and also in the world, but for Europe and world, you will send them an email
with the list of electronic components that you want to buy, for know the amount of shipping costs to your destination.
To find the electronic components on the E44 website, simply put the reference that I stated in the PDF file,
in the "search" field at the top right of the site E44 .
I chose the E44 website because I often order from them, the prices are often very low and shipping costs are not expensive.
It will also buy some components on Ebay, as the touchscreen LCD, Bluetooth module, WIFI module ...
In the PDF file "Component list.pdf" I separate the electronic components to buy from E44,
and components to buy on Ebay. For components to buy on Ebay, I can not give you links directly (or vendor names)
as prices change often (often lower). I give you the name of the component to search in the field Ebay search.
To find the correct component on Ebay, you simply specify the name that I wrote in the column "Designation" in the Ebay search.
Do not forget to search including vendors abroad (world search for best price).
By default, Ebay only offers sellers in your country (therefore prices are much more expensive).
For very low prices, choose vendors in China, vendors Chinese deliver worldwide.
Another recommendation for your search on Ebay, do a ranking by "Price + Shipping least expensive." Ebay
payments are made by Paypal, so, you need to create a PayPal account, if you do not. I buy regularly in China by Ebay,
and I've never had a problem with delivery, sellers are very serious. Delivery times are long (between 3 and 5 weeks),
but the prices are really interesting. There are several models of WIFI module, touch screen LCD, Bluetooth and micro.
On Photo01, I'll show you the right components to buy, and those that do not buy.
- For the WIFI module, you must purchase a module to 8 Pins and especially not at 10 Pins, who is not compatible.
- To the LCD touch module, you should check that it is written the word "SSD1289" for the name of the driver,
it includes SD card reader and has a single connector.
- For the Bluetooth module, you will need a bluetooth module slave 4 Pins (Those with 6 Pins are often master Bluetooth modules).
Also check that the Bluetooth module is full, as it can be purchased in two parts that you must solder. The good product
is often sold with a white cord. This cable is required to connect the Bluetooth module to the "Photographer Tools", so buy it directly.
- For the microphone, there are plenty of models, many models are only logic detection (sound is on / the sound is off).
It takes a microphone module for analog to adjust the level of detection directly with the "Photographer Tools".
The right module (the good) is very thin and long and comes with a cable (red, blue, black).
We will need this cable to connect the microphone to the "Tools photograher."
- Photo15, I show you a picture of the webcam (I bought it 2.54 Euros) and those that do not buy.
The green arrow indicates that the color of the lens is purple, which indicates the presence of a filter Anti-infrared.
I'll explain further down why you need an Anti-infrared filter. The red arrows shows the IR LEDS that fit some webcams.
These LEDs can see at night (Webcam 0 LUX) and therefore these webcams have no IR cut filter, so they do not interest us.
Help yourself with the Photo01 and the photo15 to choose the components to buy on Ebay.
For soldering components, it is necessary to use a printed circuit (PCB) because there are many connections.
This project is aimed at people who do not have the knowledge and equipment to make a printed circuit board (PCB).
To optimize and minimize the circuit board, I opted to make a double sided PCB with metallized holes.
Many holes are metallized in the connectors, and are used to pass from the first side to the second side.
So even if you have the equipment to manufacture PCB you can not do PCB with metallized holes and you can not make
contact between the two sides. That is why I propose to order the PCB to a specialized company and you send it.
I do not think hundreds of people ask me a PCB, and the post being next to my home, I therefore propose to serve,
for this a order PCB by 5, which allows a PCB for 29.87 Euros. (for one unit, the price is 80 Euros, includes company shipping).
If you are interested to make this project, send me an email (my email address is written down in the left menu of the website,
in the buttom). I'll give you the link to make a Paypal payment and I will send to you the PCB by postal with tracking.
Paypal gives you proof of payment and a guarantee if you have any doubt about my seriousness.
The sending letter with tracking, provides a guarantee that the PCB has been posted and you have received (it is a guarantee for me).
Depending on your country, Paypal takes a fee for the transaction (from 3.4% in France and 5.2% in other country + 0.25 Euros).
Here is the cost price of the printed circuit board (I rounded up a few pennies).
For France: PCB 30 Euros + 1.47 Euros Paypal fee + Shipping 3.75 Euros = 36 Euros (rounded)
For Europe: PCB 30 Euros + Paypal fee 2.03 Euros + Shipping 5,90 Euros = 38 Euros (rounded)
For the rest of the world: PCB 30 Euros + 2.28 Euros Paypal fee + Shipping 6.60 Euros = 39 Euros (rounded)
To solder the components on the PCB, you need a soldering iron (30 Watts max and fine tip) .
You can buy one from E44 for 6.90 Euros (placing your order for only once, for reduce shipping cost).
Think also of tin to solder (3 Euros for 30 grams or 9 Euros for coil of 100 grams).
Now let's get serious.
Photo02, you can see all the components needed to build the Photographer tools.
From left to right, the Arduino DUE, Bluetooth module, WIFI module, the TCS3414 sensor (color and light), the jack connectors,
the zener diodes, the two transistors, the two capacitors, the switch, the distance sensor, the red LEDs, the BPW21R for the flash meter,
the light sensor for light detection, the socket (in French = support) for integrated circuits, all resistance,
LCD touch screen 3.2 inch with SD CARD slot and finally the circuit board of Photographer Tools, and all headers (In french = barrette)
at the bottom. In this photo, there is missing one capacitor, there is missing on zener diode (I put that 3) and there is missing
the 4 integrated circuits as 4N26.
Photo03, the layout diagram of the components, it is useful, because it has both the name of the component (eg C2)
but also its value (for C2: 4.7uF). So remember to consult the Photo03, when you have a question for soldering a component.
This will allow you to be sure of its name and its value, but also the direction to weld.
Photo04, the printed circuit. This PCB is silkscreened (the silkscreen is what you see in white, the white enrollments).
The silkscreen will also allow to visualize the names of the components to be welded so as not to mislead and meaning.
Photo05, the first thing to be welded, the connectors (Headers) on the buttom side of the PCB.
These first connectors (Headers) are secured upside down relative to all the other components (side without printing = no silkscreen).
They will connect on the Arduino DUE. In this photo, there is a red arrow on the double row female connector (Header) is to show to you,
that I cut it. Originally, it is a 10-pin connector, we need 6-pin (2 x 3-pin).
It will therefore be cut with a cutter or a mini drill with a disc as a lapidary.
The double row male connector header (the great right of the photo) is the 40-pin (2 x 20), it will cut the with a cutter,
to have a 36-pin connector (2 x 18). To make all single row male connectors, I have cut the 36 pin header connector into small pieces.
Cut 5 pieces of 8 pin connectors and one 10-pin connector.
Caution ! Must be that the connectors are properly aligned for easy entry into the connectors on the Arduino DUE.
Tip: You can insert the connectors into the Arduino DUE, put the PCB over the DUE, and finally welding all connectors.
This will allow you to be sure the alignment of the connectors.
Photo06, the PCB returned. You can see the welds of the bottom connectors that you just welded.
We now solder the connectors present on the top side of the PCB. The double row female connectors 40-pin (2 x 20)
on the right is used to connect the LCD touch screen of 3.2 inches.
Above, the red arrow indicates that we will have even cut a connector, the second connector 10 pin (2 x 5 pins)
that must be cut to 8-pins connector (2 x 4). Now, you must cut the female 10-pin header, to create 2 pieces of 3 pin connector
used to connect the TCS3414. Do not forget to put the connectors (red arrows bottom) which will be used to connect the battery
and plug external power. In the middle you see the bent connectors (In french = barrette coudée) that connect the Bluetooth module,
the micro but also, future extensions and/or opportunities.
Each time, look at the pictures to be sure not to forget to have components and welds.
Photo07, welding the two transistors (BF421): Q1 and Q2.
Watch the screen, there is a flat side of the transistor, this will give you a direction for welding and do not deceive you.
The blue components with the black ring, it is the zener diodes D1, D2, D3 and D4. I put a red circle in the middle of the photo.
This is to show you that I forgot to solder a diode zener when I took the pictures.
So, take your time, check each times that you have nothing forgot, compare with the photos.
You see, even me, I made ??a mistake, I forgot a zener diode.
For soldering zener diodes, the tip of the triangle with "S" on the screen, represents the black ring of the diode.
Photo08 solder the resistors of 100 Ohms and the two capacitors.
The 100 Ohm resistors have color bands: Brown, Black, Brown and a final gold band.
There are 12 resistors of 100 Ohms R1, R2, R3, R4, R5, R6, R7, R8, R15, R16, R17, R18.
There are two capacitors: C2 in the upper left (4.7uF) and C1 (10uF) For resistors, there is no direction,
you can weld it same as you want. The capacitors have a direction (+ and -).
Look at the Photo08 on the capacitor at the top left (C2 4.7uF) we see a white band with "-",
That permit to help you to know the good direction. On the printed circuit (PCB), there are signs "+" and "-" to
avoid mistakes and help you to put the component in good direction.
Photo09, solder the 3 resistors of 10 Kohms: R9, R10 and R14 (rings colors: brown, black, orange and gold).
Solder the two resistors of 100 Kohms: R11 and R13 (rings colors: Brown, black, yellow and gold).
And finally solder resistance of 560 Kohms: R12 (rings colors: Green, blue, yellow and gold).
Photo10, solder the four sockets for integrated circuits. These sockets (support) are used to fix the 4N26 optocoupler.
These Supports for integrated circuits allow to change the component, if one day if it is damaged.
These supports have a small notch to the left, for follow the direction for welding.
This will permit to insert the integrated circuits 4N26 in the right direction without making mistakes.
The 4N26 Integrated circuits, have also, a small notch, or a point that permit to know the right direction.
Photo11 solder the jacks connectors. I cut a pin on the rear of jacks (see the zoom with the two small red arrows).
This pin serves no purpose, and is not connected to the circuit board. This allows you to set the perfect alignment when you solder it.
Photo12 solder the 4 red LEDs.
Tips: I put a piece of cardboard of 7 mm, it is that all LEDs as the same height, and are aligned (large red arrow).
The two small red arrows show to you that I made a small error in design (I designed the circuit printed while I had not yet
received the TCS3414). It will therefore bend a little the two connectors, and bend the legs a little of the TCS3414.
This has absolutely no effect on operation.
Caution ! there is a way to put the TCS3414, look at the signs "SCL" and "SDA".
There is a direction also to put the LEDs. Look at the picture of the LED on the PCB, LEDs have a flat side to put them in
the right direction.
Photo13, it remains to weld the photodiode BPW21R, there is a direction.
The photodiode have a little pin on the side . On the PCB, the small pin is designed, to not deceive you.
You can also insert the WIFI module to the connector (red arrow on the right).
Now I'll explain why, in the list of electronic components, there is a webcam. it is essential to have an anti-infrared filter.
If you do not use anti-infrared filter, values of colorimeter and the exposure meter will be wrong.
Light bulbs and the sun emit a lot of infrared that the human eye can not see.
What interests us is what the human eye sees, therefore it is necessary to eliminate the infrared.
Photo14, I show you that there are anti-infrared filters (IR cut filter) in almost all Webcam, Smartphone and mobile phones with camera.
The red arrows, show to you, the Webcam that I disassembled and broken to retrieve the IR cut filter.
It is an old Webcam which do not works (and the phone was broken also).
Top right, I made an enlargement to show to you what looks like a infrared filter.
They may have a square or round. On a white, they have a blue-green color.
When placed under a certain angle with the light, they have purple hues.
There are Webcams that have no IR cut filter. These are webcams that can see in the dark.
These webcams have small colored LEDs colorless, they are infrared LEDs for night view.
Photo15, I show to you, at left, the webcam that I bought for the project Photographer Tools, at right,
the webcams you should not buy because they do not have Ir cut filter.
The Webcam which I bought has a lens with purple reflections, which proves that it use a filter IR cut.
Photo16, the webcam bought on Ebay. To remove the IR cut filter, unscrew the lens of the webcam.
You should cut the lens lightly of the webcam with a cutter, a hacksaw blade or a mini drill with disk as a lapidary.
Take your time, do not damage the filter or strike out the filter.
You now paste this infrared filter on the TCS3414 as same as photo17.
WARNING! it is necessary to glue it only on the sides and angles, not on the surface. Do not use speed glue like super glue
because it will leave white marks as it dries. It is therefore necessary to use glue like the neoprene, neoprene glue leaves no traces.
Once glued and dry (24 hours), pass a cotton swab with glass cleaner to clean the IR cut filter surface
(on photo17, my filter is full of dust).
It remains to soldering the sensor (HC-SR04). Photo18, shows the distance sensor welded to the PCB.
WARNING! Must bend the 4 tabs on the sensor because I purposely mount upside down on the PCB.
Look good on photo18, the sensor not to deceive you (Gnd, Echo, Trig and VCC). The sensor is mounted upside down because its
height is greater than the height of the PCB located in the housing (box).
Well, you're almost finished welding the components, the "Photographer Tools" is almost ready.
There is still the light sensor (SFH203) and the power switch.
Photo19, the green arrow shows the position of the switch on the PCB. It is welded (solded) at midway of the pad on the PCB,
this corresponds exactly to the width of the housing (the box, in french = coffret).
The photodiode SFH203 is set at the same distance as the switch.
Caution ! There is a direction to put the sensor SFH203, look at the design screen printed on the PCB, there is a flat side on the SFH203.
Tip: check, with the PCB in the housing (the box) that the distances are good. It is worth checking before solder because
it is not easy to unsolder after, if you're wrong. The two arrows blue shows to you, that I have twisted the connectors
for the battery and the external power jack. Photo20, create 4 feet of 5 mm. I used lollipop sticks (chupa chups)
and old screws found at home.
Photo21, you must create two feet of 11 millimeters for the LCD. I use lollipop sticks.
You must make a small change on the PCB of the LCD touch screen. By default, the LCD touch screen are made to work with
ARDUINO UNO and MEGA, and that works with 5 Volts. The ARDUINO DUE operates at 3.3 volts.
SD cards operate at 3.3 volts. So that as SD cards operate at 3.3 volts, but the Arduino UNO and MEGA operate 5 Volts,
the manufacturers of LCD adds 3 SMD resistors to limit the voltage (the 3 small black rectangles with noted above 102 or 202 for example),
Photo22 red arrow. You can easily found these 3 resistors because they are located right next to the SD card reader
(photo22 green arrow) and you can see the tracks that connect the resistor to the SD card reader (blue arrows photo22).
If you do not change this, the SD card reader will operate at low speed, or it will not works following the model of 3.2 inch LCD touch
screen that you purchased. The change is very simple, you solder a thin wire to bypass the resistance, for not use it.
Note: On some models, there are 4 SMD components next to each other, in this case, there is the 3 resistors and a capacitor.
This capacitor will often beige or brown and is denoted "C". Do not bypass this capacitor.
It takes only do short-circuit or bypass on the 3 resistances rated "R" on the PCB of the LCD.
Before continuing and assemble the sandwich (The sandwich is the Arduino + The PCB + The LCD), you must program the Arduino DUE.
To download the program to the Arduino DUE:
I provided in the "download" (in the left menu of the website), a ZIP file named "Tools Photographer DD-MM-AAAA.zip"
(DD-MM-YYYY for the day - month - year of the last version of the ZIP file).
Unpack the ZIP file into a directory, for example: "c:\TEMP"
The ZIP file contains 4 directories and files:
- The "Readme.txt" file for version history know the ZIP file.
- The file "component List.pdf" for the list of components to buy in the folder "DOCUMENTATIONS".
- The folder "DRIVERS" that contains drivers or drivers that will be used to recognize the ARDUINO card by the computer.
- The directory "Download program into ARDUINO DUE" that contains the program for transferring the code in the ARDUINO.
- The directory "SD CARD" that contains the files and directories that you will copied to an SD card.
- The directory "DOCUMENTATIONS" which includes various PDF files.
- The directory "CALIBRATION" which contains the calibration program (see "Photographer Tools programs")
ARDUINO programming:
- Connect the ARDUINO card into a USB port on your computer (Windows XP, vista, seven, windows 8) with a micro USB cable.
The micro USB cable is connected to the USB port on the middle of the ARDUINO DUE.
- Windows detects a new USB device, if Windows can not find drivers for ARDUINO, specify the location of the driver that I provided
(for example, c:\TEMP\DRIVERS).
To correctly install the driver on Windows read this link: Installation Guide
- Now that the ARDUINO is properly recognized and installed on the computer, launch the "Download Program in Arduino DUE.exe"
in the directory c:\TEMP\Download program into ARDUINO and click on "Download the program".
A message informs you that the programming operation is complete.
SD card:
Copy all files from the folder "SD CARD" of the ZIP file (SD card formatted FAT16) on the SD card.
WARNING ! Do not copy the folder "SD CARD" but the files and directories contained in the folder "SD CARD".
Insert the SD card into the SD card slot of the LCD touch screen of 3.2 inches.
Personally, I use an old SD card that came with the purchase of an old camera. My SD card is 16 MB, but you can put a 2 GB if you want.
First test:
Now that ARDUINO DUE is programmed and the files are on the SD card, you can test the "Photographer Tools" before putting it in a box.
Disconnect the USB cable from the computer, the Arduino DUE no longer powered.
Insert the SD card into the card reader of the LCD touch screen (if you do not have already).
Plug the PCB with the ARDUINO DUE (Photo23). Plug the LCD touch screen on the PCB (Photo24).
You can now reconnect the USB cable. The "Tools Photographer" should start.
You arrive on the first screen with an image and the menu at the bottom.
With your finger or a stylus, press a button on the menu and start to discover the "Photographer Tools".
At the start of the "Photographer Tools", there is the initialization step. During this stage, some modules are tested,
as WIFI, distance sensor, the sensor TCS3414 and the SD card. If a problem is detected, it will appear in red.
Sometimes the distance sensor is in error at startup, if the distance measurement is greater than 5 meters.
Box set:
The "Tools Photographer" works, you have played around with, it is now time to put it into housing.
You are a little handyman, so you will not have problem for this last part.
Photo25, I show to you some specific cuts I made. Jack connectors being rectangular and the housing is inclined on the side,
I have cut a little the box so that it closes properly (red arrow in the upper left).
The WIFI module is a little too high (due to quartz), it will have to dig a little the box, to close it correctly
(red arrow in the middle). Screw heads that I have used to attach the LCD on the feet in lollipop is not thin,
I dug a little the box (red arrow below).
Photo26, blue arrows are important. The PCB is a little longer than the interior of the housing, I have cutting a little the
housing of the 9 volt battery. In addition to this advantage, it provides access to the USB ports Arduino DUE,
just by removing the 9 volt battery (see the Photo29). Start by cutting the housing for the 9 volt battery,
after you can begin all other cuts. It should start with that. The 2 red arrows on the Photo26, shows to you the little
microphone attached and the external power jack glued.
The green arrow shows the two connectors that will be connected to the PCB. The first for 9 Volts battery "BAT",
the second for the external power "POWER" (see the silkscreen on the PCB).
Photo27, the cuts are almost finished. The box (housing, case) is almost ready.
Tip to cut the rectangle of the LCD:
- Cut a piece of paper the exact dimensions of the LCD screen.
- Put the sandwich in the box (sandwich, it's the circuit board Arduino + LCD + PCB)
- Place the piece of paper on the LCD screen.
- Put 4 small pieces of double sided tape stuck in every corner of the paper.
- Make sure that the piece of paper is perfectly aligned on the LCD screen.
- Gently, cover the lCD with the box cover.
- The piece of paper will stick in the inside the box cover.
- You can now cut the rectangle to insert the LCD in the box cover.
This is the piece of paper who guide, for cut properly the rectangle.
For cutting, I used a mini drill with a mini disc (such as a lapidary).
But you can cut with a cutter but you will be patient because it will take time.
Photo28, we see the housing for the 9 volt battery cutted.
This allows access to two USB ports on the Arduino DUE if necessary, without open the box
(for transfert a new program or update for exemple).
To prevent the 9 volt battery touches the PCB ,and make short circuits, I glued a piece of plastic transparent.
This is the same plastic that I used to protect the sensor from dust (Photo29, red arrows).
Caution ! In the choice of plastic. It takes a semi-rigid transparent pastique as white as possible.
Look closely at the plastic you want to choose from several angles to the light.
Some plastics are slightly bluish (blue), which will distort the measurement of the colorimeter.
Tip: I used a plastic box of chocolate bread.
the Plastic on food pastry radius are often White, it is for see the product, but also because it is not the same plastic
that other plastic packaging (this is normal, it's a plastic for food).
To build the printing, on the box (all black markings on the box), I used " Laser Printer Clear Adhesive Film A4"
(search with Google, we find the unit from 2.49 Euros A4 sheet).
I provided in the ZIP file in the directory "DOCUMENTATIONS", the print model "Box.pdf."
Caution ! your LCD screen may be slightly different from mine, it is possible that the window of the LCD not correspond exactly.
In this case, do it yourself the model to print, it allows you to customize the front of the box.
I hope I have provided enough information to make by yourself the "Photographer Tools".
If you have any problems, if you have any questions, you can ask it in the forum.
I do not answer questions by email, only questions in the forum.
Sorry for my poor english, if you have correction, don't hesitate to post it in the forum,
after I will perform a correction.
All photos and texts are subject to copyright and distribution rights.
Reproduction in whole or in part, photographs and texts, without permission, is strictly prohibited.
Any commercial use of this arrangement is subject to intellectual property rights.
So thank you not to reproduce or distribute internet images and texts of this DIY.
Implementation and use of this DIY is allowed in a personal or school environment.
Copyright 2013 ThierryD - http://rienquepourlesyeux.free.fr
First update 03/03/2013
Last update 03/03/2013
Reproduction prohibited


text:
In our series A Day In the Life, we take a closer look at the busy schedules of the experts behind your favorite beauty, skincare, or medical aesthetics treatments. What you learn just might surprise you!
Forget any preconceived notions you've had about being able to do it all on your own. Wash away any guilt about not having yet achieved what you had believed you would by now. If you really want to have it all — and trust us, it is possible — you have to remember these two things: ask for help and stop trying to be perfect. Take it from New Jersey-based plastic surgeon Dr. Alexis Parcells.
"One of the tips my mom gave me was knowing when to ask for help and not feeling ashamed for asking," Parcells says. "It's okay to ask for help. It's okay to recognize what you can and cannot do."
Having grown up in a household surrounded by strong women, it makes sense that Parcells would fall into a line of work — and more specifically, at a medical practice — with predominantly female clientele. She specializes in both aesthetic augmentation and breast reconstruction (in addition to work with cosmetic injectables, as well as corrective plastic surgery for skin cancer and burns), but her end goal is always to give women the help and support they need. On top of that, she's a mother to three young girls, and is running multiple side projects.
Calling Parcells a superwoman puts it quite lightly, but she credits her husband and a team of people for helping her achieve each one of her goals — no matter how messy or imperfect things get. "You have hopes and wishes that everything is going to be perfect, but you can't think like that. It's just destructive," she says. "You're going to have your productive day, and you're [also] going to have a day with setbacks. As long as you stay focused and give yourself permission to take a year — or five, or ten years — to accomplish a goal, then it's more attainable."
To see what an "average" day in her life looks like, keep reading. She broke down her day to let us see how she juggles it all.
6 a.m.: "I am up and getting my daughters ready for the day. My three-year-old is in preschool, so getting her ready is a huge part of the morning routine. If I have an early case, I'm out the door at 6 a.m."
7:30 a.m.: "Our nanny comes in Sunday night and stays with us through Friday afternoon. She comes down and [helps us] get ready for the day. I drop my daughter at nursery school and then go to the gym for 45 minutes. I try to make time to go to the gym in the morning; it's important to have time to yourself. I had my second child during residency, and [at that point] I hadn't felt like myself in a really long time. I started working out in the gym and eating healthy, and it's still really important to me."
9 a.m - 5:30 p.m.: "I head into the office and try to see a few patients. Depending on what kind of day it is, [I do different things]. Sometimes I have patients in for laser treatments or I see pre-op and post-op patients. If there's a surgery, I'll pop in and do my portion of it."
5:30 to 6 p.m.: "This is when I try to wrap things up so I can be home to give the girls dinner, give them a bath, and get them ready for bed."
7 to 9 p.m.: "The girls are in bed by 7 p.m. This is when I work on self-improvement projects — I'm working on a lot of things! I'm designing my new website bravebras.org, which educates women on breast reconstruction. I'm trying to partner up with The BreastiesTM, a breast cancer support group started by women who talk about their cancer treatments and breast reconstruction, and I'll brainstorm ideas with them. I'm beginning to start a breast cancer support group in New Jersey, and working on all these research projects. My partner and I are trying to develop our own organic skincare line. I'll also brainstorm for my hospital's fundraiser, Fashion For The PinkTM.
There are nights where I am operating from 10 to 11 p.m. at night, but this is a general overview of what a typical night looks like."
This window of time is also when Parcells completes her evening skincare routine. "I was clueless before I joined the practice about the importance of taking care of your skin," she explains. "I've always worn SPF — I was a lifeguard — and hats. Just the daily routine over the course of the year, doing all the technical stuff twice a day, makes a huge difference."
She adds, "I'm a huge fan of SkinMedica®. I do an eight-step routine and I enjoy it. I also think going for that facial or injectable treatment is important [to me]; you have to do things for yourself."
[Editor's note: Injectable wrinkle reducers temporarily smooth the look of moderate to severe wrinkles in certain areas of the face, including the forehead, frown lines, and crow's feet. Injectable filler is a temporary treatment that adds volume to areas of the face such as the lips, cheeks, and laugh lines. Like any medical treatment, both injectable wrinkle reducers and injectable fillers have potential risks and side effects. Talk to a doctor to see if they're right for you. And learn more now by chatting with a trained aesthetic specialist.]
Saturday and Sunday: "My husband and I have a rule that we don't make plans on weekends, unless it's something big or something we talked about beforehand. Like, one Sunday, I had brunch with female plastic surgeons I'm mentoring, and I brought my girls. I didn't have any female mentorship when I went through training. I've worked with female plastic surgeons, but they weren't into mentoring. I've made it a point to be a mentor to the women following me and graduating in the upcoming years. I have a great relationship with them; they know they can always text and call me. They've even scrubbed in a few cases with me. I really enjoy fostering those relationships with them because I believe the future of plastic surgery is female. But in general, this helps us spend quality time with the girls. This is when we regroup."
SkinMedica® is an Allergan®-owned skincare line.


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Illumina Now A Buy Following Q2 Beat, Improved Sales Outlook
Canaccord Genuity upgraded shares of Illumina, Inc. (NASDAQ: ILMN) to a Buy following a strong second-quarter beat and an upgrade to the revenue guidance.
The firm noted that Illumina reported second-quarter revenues of $662 million, beating the consensus estimate of $642 million, and adjusted earnings per share of 82cents, also exceeding the Street forecast of 69 cents. Gross margins also exceeded forecast, helped by the revenue beat, partly offset by lower gross margins on initial NovaSeq.
The firm also indicated that HiSeqX consumables increased in the second quarter, thanks to strong utilization of HiSeqX in China and due to liquid biopsy studies. However, HiSeq consumables declined sequentially, as customers worked down their inventory as they prepare for conversion to NovaSeq.
On the outlook, the firm noted that the company raised its 2017 revenue growth guidance to the high end of its earlier outlook of 10–12 percent and reiterated its adjusted earnings per share guidance of $3.60–$3.70.
NovaSeq Going Strong
Analyst Mark Massaro noted that NovaSeq beat the Street forecasts as well as the management's internal order forecast for the second quarter by 30 percent. Illumina announced NovaSeq in January, which is the company's newest technology to determine the nucleotide order of a given DNA fragment.
Massaro expressed surprise at the orders from customers new-to-sequencing and the conversion from benchtop-only customers, who accounted for one-third of Illumina's 95 orders in the second quarter.
The analyst pointed out that we are only in the third quarter in what he believes to be a three-year major upgrade cycle to the Novaseq, with demand springing from all over the globe.
See also: August PDUFA Dates: Biotech Investors Stay Tuned To A Month Of Plenty
Additionally, Canaccord Genuity said we are in the early stages of major waves of cancer growth, ranging from development of companion diagnostics for targeted IO therapies to massive oncology studies.
The firm also sees robust ongoing growth in direct-to-consumer revenue and global population level sequencing projects.
"Shipments to China grew +16% and we believe China is likely to be a double-digit grower for ILMN over the next several years, driven by the Chinese Precision Medicine Initiative," the firm said.
Raising Estimates, Price Target
The firm raised its 2017 revenue estimate from $2,675 million to $2,685 million and 2018 estimate from $2,990 million to $3,010 million. The firm also increased its adjusted earnings per share estimate for 2018 from $4 to $4.30.
For 2019, the firm initiated revenue guidance of $3,250 million and adjusted earnings per share guidance of $4.90.
Along with the upgrade of rating on the shares from Hold to Buy, Canaccord Genuity also raised its price target from $170 to $215.
At the time of writing, shares of Illumina were up 2.63 percent at $199.58.
Latest Ratings for ILMN
|Sep 2020
|Canaccord Genuity
|Sep 2020
|Sep 2020
View More Analyst Ratings for ILMN
View the Latest Analyst Ratings
© 2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.
Posted-In: Analyst Color Biotech Earnings Long Ideas News Guidance Upgrades Health Care


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- The Fisher Center for Alzheimer's Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 8th Consecutive Year
- Fisher Center For Alzheimer's Research Foundation Wins Fall 2018 Digital Health Awards®
- Fisher Center for Alzheimer's Research Foundation Earns Gold Seal of Transparency from GuideStar
- The Fisher Center for Alzheimer's Research Foundation Earns Coveted 4-Star Rating from Charity Navigator for the 7th Consecutive Year
- Hear Kent Karosen, President and CEO of the Fisher Center for Alzheimer's Research Foundation, describe his new book and the power of art therapy
- Fisher Center Scientists link a Mutation That Protects Against the Development of Alzheimer's Disease
- Newly Inducted Into the Basketball Hall of Fame, Shaquille O'Neal, Joins the Fisher Center for Alzheimer's Research Foundation to Raise Funds for Groundbreaking Research in the Quest for a Cure
Anesthesia Does Not Lead to Dementia, Study Finds
October 31, 2013
A new study provides reassurance to the millions of people who must undergo major surgery each year: general anesthesia does not appear to lead to an increased likelihood of developing Alzheimer's disease or other forms of dementia.
The findings, published in Mayo Clinic Proceedings, come from an extensive analysis of people aged 45 and older living in Olmsted County, Minn. Researchers sifted through thousands of patient records, noting those who had undergone general anesthesia, commonly required before extensive surgical procedures, and those who had not. They found that undergoing anesthesia did not increase the likelihood of developing dementia in later years.
"It's reassuring we're adding to the body of knowledge that there is not an association of anesthesia and surgery with Alzheimer's," said Dr. David Warner, a pediatric anesthesiologist at the Mayo Clinic Children's Center and a senior author of the paper. "There are a lot of things to worry about when an elderly person has surgery, but it seems that developing Alzheimer's isn't one of them."
Concerns about the effects of anesthesia on the brain have been raised by reports that many patients, particularly elderly ones, experience some confusion or even delirium after undergoing general anesthesia. In some cases, memory problems or fuzzy thinking may persist for months or years after surgery and resemble dementia.
The problem may be especially acute in people with Alzheimer's. Patients with the disease appear to be particularly at risk of deterioration in thinking and memory skills following anesthesia, and some studies suggest that exposure to anesthetics may increase the risk of Alzheimer's.
Some earlier research in animals had suggested that anesthesia may damage the brain and increase the risk for Alzheimer's disease. Animals exposed to anesthesia had defects in their brains that resembled the damage of Alzheimer's, including an increase in the toxic protein beta-amyloid, a hallmark of the disease.
For the current study, the researchers identified about 900 men and women who had developed dementia in their later years. They compared them to age-matched peers who remained mentally alert and free of memory problems.
About 70 percent of the patients in both groups needed surgery requiring general anesthesia. The results indicate that elderly surgery patients who receive general anesthesia are no more likely to develop Alzheimer's or other forms of dementia over the long term than other seniors.
More research is needed to better understand the long-term effects of anesthesia on the brain. But these results do provide some reassurance for those who must undergo major surgery.
Still, a hospital stay and surgical procedure can be traumatic for anyone, particularly someone with Alzheimer's disease, who may have an especially difficult time adjusting to strange surroundings, interruption of routines and a bustle of activity. Other reports have shown that people with Alzheimer's who develop delirium may show an accelerated decline in their memory and thinking skills for at least five years after hospitalization. Though people with Alzheimer's of course may need hospitalization for legitimate medical concerns, keeping hospital visits to a minimum is always a good idea.
By ALZinfo.org, The Alzheimer's Information Site. Reviewed by William J. Netzer, Ph.D., Fisher Center for Alzheimer's Research Foundation at The Rockefeller University.
Source: Juraj Sprung, M.D., Ph.D., et al: Mayo Clinic Proceedings, May 1 online edition.


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Gas Grill Replacement Parts
OK, so you have decided to fix your grill , make it work like new again, and save money by doing it yourself. I respect that, I myself am a "Do it yourself" type of person.
Use the link to my online catalog below to find your relacement parts. When you find the parts you need, type or paste the part number and quantity in the parts fields on the order form below. Provide your billing, shipping, and payment information and hit submit.
I'll send you an email of your order with shipping costs, and tax (CA residents add 8% - 9%), I will ship your order as soon as payment has been processed. On average, shipping to California takes 3 - 4 business days. I ship with UPS.
Can't find the part you are looking for?.... or not sure what part you actually need? I may be able to help you, send me an email or give me a call with what you need and I will do my best to help, advice is still free.
The fine print: Since I have no knowledge of your particular grill, the problems you are having with your grill, or the parts needed to repair your grill. The Grill Man will not be held responsible if you order the wrong parts, the parts ordered do not fit your particular grill, or do not repair your grill problem. The Grill Man will also not be held responsible for damage to your grill or personal injury resulting from the installation of parts that you order.
Click here to go to catalog
Parts Order Form *required fields
The Grill Man, La Quinta, CA 92253, Palm Springs, Cathedral City, Rancho MIrage, Palm Desert, Indian Wells, Indio, Desert Hot Springs,
Thousand Palms, Bermuda Dunes, Coachella Valley, 760-298-46989


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Friday, July 23, 2010
It's been a busy week...we're getting ready to head out of town for a week's vacation with my entire family! I have lots of projects to share, so I'm hoping that we'll have wi-fi while I'm gone.
Today's card features more products from the new Idea Book & Catalog. I love this new Just Believe stamp set - so beautiful! I opted for a monochromatic color scheme and the new Elegant Soiree designer series paper was perfect. And check out the new crochet trim - this stuff is so elegant.
Thanks for stopping by!
Stamps: Just Believe
Cardstock: Crumb Cake, Early Espresso, Very Vanilla
Ink: Crumb Cake, Early Espresso
Accessories: Elegant Soiree designer series paper, 1-3/4" circle punch, Victoria crochet trim, stampin' dimensionals
2 comments:
- Kathy W said...
awsome creation- love the ribbon you chose- have a wonderful vacation
- July 25, 2010 at 1:09 PM
- Lynn Put said...
Beautiful Marilyn!!! I love this image with the neutral color scheme and the lace ribbon looks fantastic!
- July 25, 2010 at 3:05 PM
Subscribe to: Post Comments (Atom)


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Oscar's "Lucky 13!" Time to celebrate this year's Academy Awards with the strangest Oscar trivia imaginable: the X-rated kind! This isn't the kind of image you equate with the Oscars, is it? Well here's some obscure Academy Award trivia for… Read More ›
best picture nominee
"Nightmare Sisters!" 80's Sex Kittens Make #31DaysOfHalloween A Cult Horror Gem Done On A Dare! Linnea Quigley! Michelle Bauer! Brinke Stevens!
Looking for an over-the-top camp 80's classic horror film for Shocktober 2018? How about a cult gem starring these three? Have Some Fun With Quigley, Stevens & Bauer! It would be the most popular law firm EVER: 80's sex kittens… Read More ›


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MIDDLETOWN, Conn. – The Wesleyan University men's lacrosse team is ranked No. 17 by Inside Lacrosse in its 2017 Face-Off Yearbook preseason rankings, and No. 19 in the USILA/NIKE Division III Men's Lacrosse Preseason Coaches Poll.
The Cardinals are coming off an impressive 2016 season in which they finished 10-5 overall and 6-4 in the ultra-competitive NESCAC. There are six teams from the conference ranked in both the Inside Lacrosse and USILA/NIKE preseason polls; No. 5/2 Tufts, No. 9/11 Bowdoin, No. 11/16 Bates, No. 13/9 Amherst, No. 16/15 Middlebury and No. 17/19 Wesleyan. The Cardinals are 18-14 all-time in the conference championship, and are just one of five teams to advance to the tournament 15 times.
To see the full Top 20 rankings, click on the following links: Inside Lacrosse l USILA/NIKE


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Mason Proffit "Wanted"
The Mason Proffit name is quite well known in these Chicago parts. I'm really not so sure outside of this market. I look forward to hearing from those not in our backyard.
Mason Proffit was a mid to later 60s to early 70s band that was founded and fronted by the Talbot brothers, Terry and John-Michael. They both played guitar and supplied the writing and the vocals.
They were actually one of the originators of country-rock. It would be nice to see their name included more when someone tosses out names on the subject. They really should be recognized more.
One song that you may recognize is their classic tune, 'Two Hangmen.' Now does the name Mason Proffit jump out at you a little better?
That song still gets airplay and it's very well deserved.
John-Michael and Terry have continued to make music to this day. They've made a nice name for themselves singing about their faith. They've been honored with numerous Grammy and Dove Awards.
Track Listing
- Voice Of Change
- A Rectangle Picture
- You Finally Found You Love
- Sweet Lady Love
- Stewball
- Two Hangmen
- Buffalo
- Walk On Down The Road
- It's All Right
- Till The Sun's Gone
- Johnny's Tune
- John-Michael Talbot – Banjo, Guitar, Vocals
- Terry Talbot – Guitar, Jew's-Harp, Percussion, Vocals
- Tim Ayers – Bass
- Rick Durrett – Piano
- Johnny Frigo – Fiddle, Violin
- Art Nash -Drums
- Ron Schuetter – Guitar, Vocals
- Bill Traut – Producer
- Listen to "Wanted" in it's entirety Here
- Terry Talbot and Mason Proffit Band Official Website
- John-Michael Talbot Official Website
- Mason Proffit on Wikipedia
- Mason Proffit on AllMusic
- See more from 1969 that we've featured


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Just last week I had the pleasure of attending an event at Lush to celebrate the launch of their new makeup line in the Belfast store. I was really excited to try this makeup line as it is quite different to a lot of brands out there in that - it's completely plastic and packaging free. The products come raw in cardboard recyclable boxes and have wax at the end which can also be recycled. So I'll go through each product I've tried and show the finished look on my face also.
Slapstick Foundation in 6C
The first product I tried was the Slapstick Foundation, I have to say I am more of a liquid foundation girl so I didn't really think I would like this product. But I have to say I really like it, I would say it's a medium coverage and you can build it up. It's probably more of a daytime foundation for me as I prefer a fuller coverage for night outs and it's also quite dewy. I did find the product itself really easy to apply as I just swiped it on my face and blended it with a foundation brush. It also feels very lightweight on the skin, so would be great for holiday too.
Trix Stick Concealer in
The Trix Stick is Lush's answer to concealer, and as concealer's go it's ok. However I do prefer a liquid concealer. This concealer is kind of just a smaller version of the foundation to be honest and I think it's ok for covering spots but I personally wouldn't really use it for highlighting. It's probably the only product I'm not really that keen on, but I think that's more due to personal preference than anything.
Glow Stick in Lark
This is my absolute favourite thing in the collection, I can't emphasise how much I love this! I love an intense highlight and this certainly gives you one, the shade Lark is a pinky-silver and is prefect for a lighter skin tone like mine. There is a great shade range also and this is so easy to apply you can simply apply it straight onto your cheekbones and nose. It's not glittery at all and just gives an amazing glow. Honestly get your hands on this if you haven't already.
Refillable Lipstick in Tomsk
I cannot recommend this lipstick enough, it's very moisturising and creamy on the lips and not drying at all, which I love. I chose the shade Tomsk which is a very dark brown but there is a massive shade range to suit everyone. I love the idea of the refillable case as well.
Finished Look:
I mean look at that glow.
Thank you
Hannah x


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Today LG has launched its new smartphone K7 LTE which is the 1st manufactured device from LG from Noida plant in India. As promised previously, this device comes with VoLTE (Voice Over LTE) and VoWiFi (Voice Over Wi-Fi) support. The company is also targeting to produce and sale 1 million smartphones within this year from the plant. Let's check out the other specifications of LG K7 LTE.
Specifications of LG K7 LTE
- 5-inch FWVGA In-cell Touch 2.5D curved glass display
- Quad-Core 1.1GHz Qualcomm Snapdragon 210 (MSM8909) processor
- Adreno 304 GPU
- 8GB Internal memory
- External memory can expand up to 32GB with microSD
- 5-Megapixel autofocus rear camera with LED flash
- 5-Megapixel front-facing camera
- Android 5.1 Lollipop
- 4G LTE with VoLTE, Bluetooth 4.0, Wi-Fi 802.11 b/g/n, GPS
- 2,125mAh battery
LG K7 LTE comes with a 5-inch FWVGA In-cell Touch 2.5D curved glass display. The device is powered by Quad-Core 1.1GHz Qualcomm Snapdragon 210 (MSM8909) processor with Adreno 304 GPU and 1.5GB RAM. The internal memory comes in 8GB variants which can be expanded upto 32GB using microSD. The device runs on Android 5.1 Lollipop.
The primary camera is 5-megapixel with LED flash which can record upto 720p videos. The front-facing camera is also 5-megapixel camera.
This device comes with 4G LTE with VoLTE, Bluetooth 4.0, Wi-Fi 802.11 b/g/n, GPS connectivities. It has a 2125mAh battery under the hood.
LG K7 LTE is priced at Rs. 9,500 and will be available soon. This device comes in Titan, Gold and White colors.


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West Yorkshire Police stormed a house in Keighley where they discovered a cannabis farm with a value of £80,000.
Suspicions were aroused when eagle-eyed officers spotted a house near Arctic Street with no snow on the roof, despite the freezing conditions.
Upon further investigation they found a strong smell of cannabis coming from the property.
Their suspicions were confirmed when they entered the property where officers found 322 cannabis plants growing in all four bedrooms and in the cellar. Heated lamps which had been used to grow the plants had caused the ice and snow to melt off the roof.
Posting an image of the cannabis farm, PC Caroline Foster said: "Hmmm, I wonder why there is no snow on your roof? 280+ plants seized from an address in Keighley today, some nearly 6ft tall."
Vicky Watson, 44, who lives next door said she had her suspicions about the occupants of the terraced property when they moved in. She had also noticed how warm the walls of her own home had become recently.
"'Two Eastern European blokes, in their 30s, moved in about 18 months ago," she explained.
'"In the cold weather my house is normally freezing because the insulation is rubbish, but since they moved in next door my bathroom has been absolutely red hot. The wall was warm to touch.
"It was suspicious, you could hear fans whirring but no normal sounds of people living there," she added. "They were two blokes with no kids. We thought they were gay.'
Another neighbour praised the police for their swift actions in seizing the haul.
"Over the last few days the smell has got pretty strong and after the snow kept thawing on their roof, you just knew they were growing cannabis.
"Well done for the police turning out on such a freezing cold day to take those drugs off the streets. Now those cannabis farmers have lost their crop I dread to think how they are going to afford their leccy bill."
No-one was found in the house when police arrived and there have been no injuries. There have been no arrests.
According to Mail Online, work is now underway to confiscate the plants, which will be officially examined and valued.
Anyone who has information about drugs in Keighley is asked to contact the Keighley NPT on 101 or the independent Crimestoppers charity on 0800 555 111.


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By Stephen Nakrosis
HandsFree Labs Inc. on Wednesday said it received a strategic
investment from athletic footwear and apparel company Nike, Inc.
HandsFree offers Foot Activated Shoe Technology, or F.A.S.T.,
which allow people to step in and out of shoes without using their
hands, the company said. The company sells footwear in the casual,
dress and outdoor segments, and plans to launch an athleisure
brand, it said.
The Nike investment "includes an intellectual property license,
and extends the reach of HandsFree Labs' patented portfolio of Foot
Activated Shoe Technology solutions," HandsFree said.
HandsFree said in addition to the Nike deal, it plans to "roll
out its technology through licensing deals with other footwear
categories and manufacturers."
HandsFree Labs is based in Vineyard, Utah.
--Write to Stephen Nakrosis at email@example.com
(END) Dow Jones Newswires
November 20, 2019 17:36 ET (22:36 GMT)


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Xerox Emirates offers virtual world
Xerox Emirate customers are in for a surprise when they log on this month by way of the company's newly enhanced website, which is said to offer a unique virtual experience to Xerox shopping.
Xerox Emirate customers are in for a surprise when they log on this month by way of the company's newly enhanced website, which is said to offer a unique virtual experience to shopping around for Xerox products.
Xeroxuae.com the company claims, will allow customers single-point, integrated access to its full range of products and solutions as part of the company's strategic intention to transform the way people relate to information and work.
"Today is all about becoming aligned with the Internet economy," said Ayman Mattar, marketing manager for Xerox Emirates. "Since we last launched the website we have enhanced every aspect of it - from virtual demonstration to customer service calls—in order to develop a more responsive and effective business offering. With this renewed strength, we will now deliver unparalleled, substantial value to our customers in the region."
Among the many enhancements customers can now look forward to using are a more powerful search engine, the new virtual demo room offering customers a 'look and feel' option, and the option to log in service calls directly from the web.
Xerox Emirates is also implementing a secure order page, which will enable customers to purchase select products online using a secured credit card facility. Additional features include a service page that allows customers to communicate in real-time, updates on product innovation, plus information on special price and product offers.
"We are excited to offer customers the opportunity to make informed purchases through our web-site. This clearly reflects Xerox's commitment to provide ongoing innovative products and solutions to customers in the UAE," commented Mattar.


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Healdsburg, CA — Coming this June, Bear Republic Brewing Company┬« fan favorite Café Racer 15Ôäó is racing back to shelves and arriving in a store near you. A seasonal release, Café Racer 15Ôäó is one of our finest offerings available, with vastly limited production and distribution.
"Bear Republic has won a medal in all of the pale ale categories, and this beer was the last to win in the cycle," states Brewmaster and COO Richard Norgrove.
Café Racer 15Ôäó is a Silver Medal Winner at the 2012 Great
American Beer Festival® in the Imperial India Pale Ale Category up against 128 other entries, and a winner at the 2014 Good Food Awards.
Norgrove adds, "We are very proud of this win in the ever expanding world of IPAs. This is a seasonal people have been known to count on."
About the beer:
Description: Café Racer 15Ôäó features aromas of bright citrus and resinous pine from the generous use of Citra, Amarillo, Cascade and Chinook hops which are complimented by a dry malt finish. The result is a high revving Double IPA that is loud and assertive, much like the rebellious street racers who inspired it. Never ride alone…
Pairing Suggestions: Spicy Foods, Savory Dishes, Poultry & Pork Dishes, Parmesan Cheese, Aged Cheddar & Sheep's Milk Cheeses
Availability: Limited 22 oz. bottles and draft
Hops: Citra, Amarillo, Cascade, Chinook
ABV: 9.75% – IBUs: 100+ – Double IPA
To find Café Racer 15 near you, please visit www.bearrepublic.com/bear-tracker


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Juve, Dybala on what intrigued him most about Ronaldo
09 November at 15:25Cristiano Ronaldo moved to Juventus in July for around €110m, leaving Real Madrid and La Liga behind to bring his experience, flair and talent to Italy and Serie A. There was a lot of speculation about how Ronaldo and Paulo Dybala would work together but it is suffice to say that they are working well and developing a close bond. Speaking at the press conference ahead of Juventus' Sunday clash with AC Milan, Dybala spoke to Sky Sport about Ronaldo:
"I was more intrigued by how he was inside the locker room, we all know him on the field, he has shown great professionalism and calm, he is a great person and he is showing it every day and has a good relationship with everyone. It's what I was hoping for - I was the first Juventus player with whom Ronaldo took a selfie, he's going strong on the social networks (laughs). It was one of the first training sessions, we played ball games, we were together in the team and we won."
For more news, views and features, visit our homepage.


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Every Windows user is aware of Windows Explorer or file explorer that we all use to browse and manage files/folders. Users who often use the Explorer always complain about the default white background of the Explorer and want to change the default background color to a new color that is easy on eyes.
While Windows allows changing file or folder icons, it doesn't let you change the default background color of the Explorer. While it's possible to set a custom picture as Explorer background in Windows XP without installing a third-party tool, the workaround doesn't work in Windows 7.
So Windows 7 users have to go for third-party tools to change the default color of Windows Explorer background. If you're looking to have a custom background for the Explorer, you can now use a free tool named Windows 7 Folder Background Changer.
Change Windows 7 folder background
Windows 7 Folder Background Changer is a standalone tool for Windows 7 to change the default white background of folders with ease. The tool is fantastic and is the only available for Windows 7 to change the folder background image with a click.
With the Folder Background Changer, one can change the folder background as well as folder or file text color. The tool also lets you apply the changes to sub folders. Please note that one needs to run this tool as an administrator (right-click on the tool and select Run as administrator option) to run it without any errors.
Download, extract the contents and run W7FBC (.exe) with administrator rights to start customizing folder background and text color. First, select the destination folder that you want to change the background, click the Change Background Image button to select your custom image. You can revert to the default background by clicking the Remove Background Image button.
Note that it doesn't let you set a solid color as Explorer background. And, if you want to change folder color, please refer our change folder color with Rainbow Folders article.
NOTE: If you're having issues with this tool, we recommend you check out AveFolderBg tool.


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|Fossilfreemac-l -- Fossil Free Macalester
|About Fossilfreemac-l
As a respected institution of higher education, Macalester College's investments should reflect its values. Our investments in fossil fuels contribute to climate change, which is disproportionately harming marginalized communities in the United States and the world. Divesting from fossil fuels is the single biggest climate justice action Macalester College can take. Therefore, we call on Macalester College and the Board of Trustees to fully divest from fossil fuels within five years and permanently ban any new investments in the top 200 fossil fuel companies. We additionally call on the Board of Trustees to reinvest in socially responsible investments.
To see the collection of prior postings to the list, visit the Fossilfreemac-l Archives. (The current archive is only available to the list members.)
|Using Fossilfreemac-l
To post a message to all the list members, send email to
You can subscribe to the list, or change your existing subscription, in the sections below.
|Subscribing to Fossilfreemac-l
Subscribe to Fossilfreemac-l by filling out the following form. You will be sent email requesting confirmation, to prevent others from gratuitously subscribing you. Once confirmation is received, your request will be held for approval by the list moderator. You will be notified of the moderator's decision by email. This is also a hidden list, which means that the list of members is available only to the list administrator.
|Fossilfreemac-l Subscribers
version 2.1.15


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A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk.
The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
Anterior pituitary cells that produce PROLACTIN.
The intermediate lobe of the pituitary gland. It shows considerable size variation among the species, small in humans, and large in amphibians and lower vertebrates. This lobe produces mainly MELANOCYTE-STIMULATING HORMONES and other peptides from post-translational processing of pro-opiomelanocortin (POMC).


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Jo-Anne Brant
Brant, Jo-Anne
Passed away very peacefully surrounded by family at Conestoga Lodge Friday October 12, 2012 at the age of 72. Beloved mother of Aubrey (Laura) Nelson, Violet Spence, Charlene (Steve Ivancic) Bain, Leonard "Paul" (Kerry) Nelson and Ronald (Kristine Cummings) Brant. Cherished grandmother of 15 grandchildren and 5 great-grandchildren. Dear sister of Ron Brant and Barney Brant.
Predeceased by brother Doug, sisters Kay and Bea and grandsons Michael and Kyle.
There will be no services held for Jo-Anne due to her wishes. Her body has been donated to medical science. Donations can be made to the Canadian National Institute for the Blind or the Lung Association through the Henry Walser Funeral Home, 507 Frederick St., Kitchener, 519-749-8467


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Writing Skills
Join our small supportive writing group and be guided by our experienced tutor. Whether you are returning to education or if writing skills are important in your job, we are here to help you improve.
Touch Typing
Fed up with doing 'hunt and peck'? Complete our intensive course, 5 daily 1 hour sessions, and by the end you will know all the letter keys and have moved on to simple punctuation and number keys. Just imagine how much time you will save!
Study Skills
Returning to education? Professional exams to take? We can help you develop a range of multi-sensory revision strategies suited to your learning style, use your time more efficiently and learn effectively.


text:
The Project Manager Magazine - advertise in The Project Manager Magazine in South Africa
The Project Manager Magazine has been reviewed 2405 times.
About The Project Manager Magazine:
The Project Manager Magazine is a publication for project management professionals in South Africa.
Distribution Areas:
Project Management South Africa (PMSA) membership
Top JSE-listed companies
Key procurement directors in government
Selected procurement directors in corporate South Africa
Selected members of the Association of South African Quantity Surveyors (ASAQS)
Selected members of the Chartered Institute of Builders (CIOB)
Selected members of the South African Council for Project and Construction Management Professions (SACPCMP)
Selected tertiary institutions
Selected members of the South African Institute of Architects (SAIA)
Members of the Chamber of Mines
SADC regions
The Information Technology Ass. of S.A. (ITA)
Members of the SA Institute of the Interior Design Professions (IID)
To advertise in The Project Manager Magazine - click here
Advertising has never been so easy � simply click on the request a quote button and we do all the work from there including giving you the best rates and prices on your advertisement.
For the best in the Project Manager magazine advertising rates. Call us Today.
Visible Advertising - We make advertising easy again.


text:
Casa Grande
Jan. 28, 2014Brazil117 Min.
what going on?
As a privileged teenager living in an affluent suburb of Rio de Janeiro, Jean has little to worry about beyond games, grades and girls. But as his overbearing father drags the family into debt, Jean is forced into a change of lifestyle which opens his eyes to the world beyond his 'casa grande' – not least that of the feisty, mixed-race firecracker Luiza. Cultures, classes and generations collide in this engrossing coming-of-age drama from Brazil.
Original title Casa Grande
IMDb Rating 7.0 1,520 votes
TMDb Rating 7.3 25 votes


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Two weeks ago I saw a post about this new
open source end-to-end software development platform with built-in version control, issue tracking, code review: this post. I signed up to see what does this new platform look like. And after two weeks I can give my mind.
⚠ I'm only 15 yo, my English isn't perfect and I want to improve it so if you notice a language error, say it in a comment. ⚠
Good points
- It is new and open source
I don't know if it's an argument but in my mind, that's very important.
I love open source alternatives. This is based on Gogs which is self-hostable.
- Simple user interface
The first thing I noticed is the user interface, so simple and so easy to understand, okay some people can say it is a copy paste of the Github's design but that's not a problem for me.
- Visibility
Gitote is made with the concerns of the social. There is an Explore page which is absolutely amazing I discovered a lot of good projects especially Just Another shell or Full Tilt Bash.
Negative points
- No unit testing service
That's a big problem for me, I need unit testing but today if you want to use a unit testing service you will have to create a mirror on Gitlab/Github.
EDIT: Gitote is setting up a drone-ci instance.
- I don't know but I have to find other negative points
I don't say you should use it instead of Gitlab/Github/Bitbucket but you should still try Gitote. I forgot to mention that I am remote intern at Gitote but I said all the things I thought about it good or bad.
There is not a lot of people for now on Gitote but I think the popularity is only a matter of time.
Posted on by:
Erwan ROUSSEL
Erwan ROUSSEL, Young dev (17yo) ⛓, NodeJS and Golang enthusiast 🚀 Flume Cloud Services creator (https://github.com/flume-cloud-services) ☁ and blogger ✍ Contributor of oh-my-zsh ✨
Thank you for the review Erwan. I too say the original post and was curious of Gitote.
As for the grammar:
- "It is new and open source" That is two points. New != Open Source AND Open Source != New (see Linux Kernel).
- "..., so simple and so easy to understand,..." It sounds better as "..., it is (referring to the UI) so simple and so easy to understand. (full stop period)"
- "... I forgot to mention that I am remote intern at Gitote but I said all the things I thought about it good or bad...." Typically interest conflicts are stated at the beginning of an article to inform the reader of your (possible) conflict of interest.
Overall though, nice article.
Dude, awesome resource even if you shilling for them :P
Though I would say you seem more than honest and honestly its not like you are racking in mucho dinero interning for an extremely new site such as that.
I was instantly attracted to the "Useful Explore" potential. Wow it is actually useful. I will be forking and modifying for a while now. Thank you!
PS still want to write an article
I think
I want to perform to should be
I want to improve 🙂
Nice! Thanks for sharing this! 👍 I always want to see an alternative to the Big 3 (GitHub/GitLab/BitBucket), even if it's very similar. I'll be keeping an eye for this as it develops further.


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Debt restructuring and the formation of a REIT
Caesars Entertainment Corporation (CEC) will merge with Caesars Acquisition Company (CAQC), established in 2013, in an all-stock merger deal that will enable subsidiary Caesars Entertainment Operating Company (CEOC) to ultimately restructure as a real estate investment trust (REIT) as it moves ahead with plans for a voluntary Chapter 11 reorganisation bankruptcy filing scheduled for early next year.
"The highly efficient REIT structure would enable CEOC to maximize its value and provide the most financial recovery to each of CEOC's creditor groups," said Gary Loveman, chairman and chief executive officer of Caesars Entertainment and chairman of CEOC.
"The formation of a publicly traded REIT would also allow CEOC to significantly reduce its leverage by creating two better capitalized companies with vastly improved cash flow generation."
Loveman will remain as chairman and chief executive officer of the combined Caesars Entertainment until the end of 2016.
Industry veteran Mitch Garber will continue to serve as chief executive officer of Caesars Interactive Entertainment and will take on the role of vice-chairman of the combined company.
Online Casino News Courtesy of Infopowa
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