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Bakery owner Willow Dalton's friendship with Zane Walker has always been a bit complicated. Now a scrumptiously hot A-list actor, Zane's always had a reputation as a player. He's arrogant, and he's definitely not boyfriend material. Sure, he did Willow a favor by agreeing to take her virginity before college, but is that reason enough for her to go along … Read More
A Kingdom's Cost: A Historical Novel of Scotland (The Black Douglas Trilogy Book 1)
Eighteen-year-old James Douglas can only watch, helpless, as the Scottish freedom fighter, William Wallace, is hanged, drawn, and quartered. Even under the heel of a brutal English conqueror, James's blood-drenched homeland may still have one hope for freedom, the rightful king of the Scots, Robert the Bruce. James swears fealty to the man he believes can lead the fight against … Read More
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A royal hero. A butt kicking heroine. And a dragon to bind them all together. As the bastard child of the King of Gregorick, Tattiena holds no right to the power of the throne. Yet, as one of the last dragon riders on Limea, she is the city's first line of defense against their enemies. A heavy responsibility for a … Read More
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Gage was the first guy I ever wanted. He was my first crush and my first fantasy, but he wasn't my first in any other way because he never saw me as anything more than a friend— at least not until the night that changed everything. It was all Gage's fault. He insisted we drive through the storm and take … Read More
Mr. Dirty (London Billionaire Book 3)
My life was great until my new neighbor made my life impossible. She can't stand me. And the feeling is mutual.She's annoying, and persistent, and a pain. She's also gorgeous, and smart…and completely immune to me. But now she needs my help with a little Ex payback and I'm more than happy to lend my expertise. Now all I have … Read More
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What Readers are saying: "… Be Prepared to be EMOTIONALLY PULVERIZED…" "… this is the BEST series I've EVER READ…""…WON'T be able to PUT it DOWN …!"Individual star rating Singers: 3.9 Song: 4.3 Chosen: 4.1 From the New York Times bestselling author of, A Terrible Love, comes 3, full-length dark paranormal romance novels. A Shade of Vampire meets Twilight in a dark tale of twisted loyalties, … Read More
Night of the Wild Stags: A Reverse Harem Romance
Kiara Arrio is on the run and dying when four tall, dark, and gorgeous strangers find her in a crumpled heap along the road to the hospital she was desperately trying to reach. The small herd of stag shifters are immediately drawn to the injured woman, taking over her care as she recovers from her illness. They're entranced by Kiara's … Read More
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"Tom Bielawski is a bright light in today's dark sea of new writers. His writing gives me hope for the next generation of dreamers. I highly recommend both him and his works." – NYT Bestselling author, Tracy Hickman. A dark and powerful magic, lost the world for centuries, stirs once more. The Dark Disciples, infamous villains once thought vanquished, have … Read More
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Their worlds were different, but their desires were the same . . . Isabella McCoy, from the banks of the Chattahoochee River in Georgia, was as naïve as she was beautiful. Jacqueline Rousseau, the exotic New Orleans prostitute, was known for cruelly breaking men's hearts while she emptied their pockets. Both with dark secrets of their own, running away from … Read More
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Convicted of a series of horrific crimes against young college students in upscale Santa Barbara, wealthy playboy Charlie Mendez has fled across the US border into Mexico. As one bounty hunter after another meets a grisly end at the hands of the murderous drug cartel his family have hired to keep him safe, it seems that Mendez is one fugitive … Read More
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Murder. Suspense. Romance. And some handy household tips. IN BOOK 4 OF THE HOUSEWIFE ASSASSIN SERIES: London. Paris. Guantánamo Bay. Donna Stone is looking for love — and terrorists — in all the wrong places. Donna Stone finds out that breaking up is hard to do. Then again, so is dating a terrorist, let alone eleven of them! Does this … Read More
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How do you protect your heart? Build a wall.Lock it away.Let no one in. Everyone should have a childhood worth remembering. Only I remember mine for all the wrong reasons. Starting over in a new town is hard enough. When you are running from your past, it doesn't get any easier. I was ready to say goodbye to the burdens … Read More
21 Stolen Kisses
When I first met him I resisted. Like any forbidden love, I told myself he was a crush, and it would pass.That was a lie. It never faded.And I never expected he would fall for me just as hard. There were so many reasons that should have kept us apart, least of all, the decade that separated us.Growing up in New … Read More
30 First Dates: a romantic comedy (Unlucky in Love Book 1)
From USA Today bestselling author Stacey Wiedower… 30 dates, 30 wild ideas, total media frenzy… but only one Mr. Right. Erin Crawford is a relationship blogger with a bucket list and a vendetta. After having horrible luck in her own relationships, she decides to start a blog called "30 First Dates." Her mission: go out with 30 men before her … Read More
The Mountain Midwife
Coming from a long line of mountain midwives, Ashley is torn between her dream of attending medical school and her guilt for abandoning the women who depend on her. "Expertly crafted and filled with mystery and intrigue . . . sure to delight historical romance fans." —Sarah E. Ladd, author of The Weaver's Daughter, on A Stranger's Secret For nearly … Read More
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When your boyfriend bets YOU in a poker game, you better know when to run… Bad enough Jade Frost's boyfriend drags her to an illegal gambling house. Even worse that he actually threw her into the betting pot during an intense round of poker…and lost. Talk about the perfect excuse for Jade to make him her ex-boyfriend. Now she supposedly … Read More
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"A modern conservative classic." – Sean Hannity "Men in Black couldn't be more timely or important….a tremendously important and compelling book." – Rush Limbaugh "One of the finest books on the Constitution and the judiciary I've read in a long time….There is no better source for understanding and grasping the seriousness of this issue." – Edwin Meese III "The Supreme Court … Read More
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Even more books of the author on sale today!
The beloved novel set at a Jane Austen fantasy resort, from New York Times-bestselling author Shannon Hale. Recently adapted into the romantic comedy film Austenland starring Keri Russell and Bret McKenzie and directed by Jerusha Hess. Jane Hayes is a seemingly normal young New Yorker, but she has a secret: Her obsession with Mr. Darcy from Pride and Prejudice is … Read More
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Expect the unexpected, especially in a room filled with books. . . Honoria Duchamp is well aware that men often consider widows easy prey for the role of mistress. What else could explain the attentions of handsome Lord Devin, and his visits to her bookshop? The much younger Viscount has even shown interest in the printing press with which she … Read More
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New York Times bestselling author Melody Anne's sizzling novel of ex-lovers locked again in a game of hearts. There was a time when surgeon Kian Forbes would have surrendered every cent of his vast family fortune if it could make Roxie Gilbert happy. That was before she skipped town, broke his heart, and sent him spinning through a string of … Read More
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WBJEE 2019 Notification
WBJEE Notification has been released by West Bengal Joint Entrance Examination Board for candidates who want to get admission in Architecture, Pharmacy and Engineering courses. Check now WBJEE Exam Dates & WBJEE 2019 Registration process from this page. Applicants are also informed that WBJEE Admit Card has been released on the official website of the organization.
Latest Update!!!
WBJEE Admit Card 2019 Available!!
Applicants are notified that the WBJEE Admit Card 2019 is now uploaded for the Entrance Exam scheduled to held on 26-05-2019. Candidates going to appear in the WBJEE 2019 can obtain the WBJEE hall Ticket through below provided direct link.
Overview of WBJEE Exam Notification:
- Name of University: West Bengal Joint Entrance Examination Board
- Admission For: Architecture, Pharmacy and Engineering courses
- Opening Date to Fill Online Form for WBJEE Notification 2019: 26-12-2018
- Apply Online Last Date for WBJEE 2019: 22-01-2019
- Availability of correction window: 23-01-2019 to 25-01-2019
- Status of WBJEE Admit Card: Available
- WBJEE 2019 Exam Date: 26-05-2019
- Date of WBJEE Result: 02-07-2019
- Official Website: www.wbjeeb.in
Official Links Related to WBJEE 2019
|WBJEE 2019 Official Notification
|Download PDF
|WBJEE Official Notification in Bengali
|Download PDF
|WBJEE 2019 Important Dates
|Check Here
|WBJEE FAQ's
|Check Here
|WBJEE Guidelines for Online Application
|Check Here
|WBJEE Old Question Paper
|Check Here
|WBJEE Official Website
|Press Here
WBJEE 2019 Notification
WBJEE Courses:
As per WBJEE Notification PDF, Under Graduate Courses Will Be Offered In The Following Stream, take a look…
- Engineering & Technology
- Pharmacy
- Architecture
WBJEE Eligibility 2019:
Students who are going to apply for West Bengal JEE Notification, are suggested to go through below stated information to check the eligibility norms
Candidate must be the citizen of India.
Required Qualification for Notification Of WBJEE 2019
For Engineering:
- Candidate must have passed 12th or equivalent examination from recognized board.
- Qualifying exam must have been passed with Physics and Mathematics along with any one of Chemistry/Biotechnology/Biology/Computer Science/Computer Application as compulsory subjects.
- Candidates must have passed individually in all the three subjects.
- One should obtain 50% marks (40% in case of reserved categories) in three subjects taken together.
- Must pass English with at least 30% marks
For Pharmacy Course –
- Candidates should qualify 10+2 examination from recognized board.
- Candidates must pass with Physics and Chemistry along with any one of Mathematics/Biology as compulsory subjects with individual pass marks in all the three subjects.
- Candidates must secure at least 45% marks (40% for SC, ST, OBC-A, OBC-B, PwD category) in all three subjects taken together.
- Candidates studying in 12th are also eligible to apply.
Check More Links Related to WBJEE 2019
|WBJEE Exam Pattern
|Get Here
|WBJEE Model Question Paper
|Get Here
|WBJEE Results
|Get Here
|WBJEE Answer Key
|Get Here
|WBJEE Counselling Process
|Get Here
|WBJEE College Predictor
|Get Here
|WBJEE Rank Predictor
|Get Here
|WBJEE Cut Off
|Get Here
|WBJEE Rank Vs Marks
|Get Here
|WBJEE Evets
|Get Here
West Bengal JEE Exam Fee:
- Students should need to pay Rs. 500/- as an examination fee for WBJEE 2019 Exam as per WBJEE Notification.
- Fee will be paid in cash less mode by 'Net Banking'/ 'Debit Card'/ 'Credit Card' or in cash using Allahabad Bank e-challan.
Do You Know: How To Pay Fees Online Through Credit/Debit Card
WBJEE Selection Process:
Contender's admission will be based on the following WBJEE Admission Process that is qualifying marks in West Bengal Joint Entrance Exam followed by WEJEE 2019 Counseling.
WBJEE 2019 Exam Pattern:
The West Bengal JEE Exam Pattern as provided below in tabular format, take a look…
- Mode of Exam: Exam will be organized via through offline (OMR) mode.
- Duration of Exam: To complete the exam 2 hours will be provided
- Type of Questions: Multiple choice questions (MCQ) will be asked.
- Negative Marking: In category- I & category II, 0.25 marks will be deducted for each wrong answer however for category-III there is no negative marking.
|Type of questions
|Objective (MCQs)
|Mode of examination
|Exam Duration
|4 hours
|Marking scheme
|+1 or +2 for each right response
|Negative marking
|Language of examination
|Three i.e. Physics, Chemistry, Mathematics
WBJEE Exam Pattern:
|Cat-I (1 Mark)
|Cat-II (2 Marks)
|Cat-III (2 Marks)
Must Know: How Do Toppers Study?
Points To Be Noted:
- In Category I: Only one answer option is correct
- In Category-II: Only one answer option is correct
- In Category-III: One or more answer options are Correct
WBJEE 2019 Exam Centers
Candidates can check the district-wise WBJEE exam zones as per WBJEE 2019 Notification Pdf from the following table:
|Bankura, Bishnupur
|Bolpur, Suri
|Paschim Burdwan
|Asansol, Durgapur
|Purba Burdwan
|Kurseong, Siliguri
|Dakshin Dinajpur
|Uttar Dinajpur
|Arambagh, Bandel, Chinsurah, Srirampur
|Bally, Uttarpara, Central Howrah, Shibpur, Domjur, Uluberia
|Central Kolkata, North Kolkata, South Kolkata
|Paschim Medinipur
|Garbeta, Kharagpur, Medinipur
|Purba Medinipur
|Berhampur, Raghunathganj, Jiaganj,
|Kalyani, Krishnanagar, Nabadwip
|Barrackpur, Barasat, Bongaon, Basirhat
|Diamond Harbour, Jainagar, Sonarpur, Baruipur
Outside West Bengal:
The state-wise WBJEE exam cities outside West Bengal are given below in the table:
Check Out: Engineering Entrance Exam Calendar
West Bengal JEE Syllabus:
Students, who wish to qualify West Bengal Joint Entrance Examination, are advised to start preparation through WBJEE 2019 Syllabus. You can open below provided link to download WBJEE Exam Syllabus.
WBJEE Hall Ticket
The WBJEE 2019 Admit Card is now available on the official web portal of the West Bengal Joint Entrance Examination Board. Candidates can download the West Bengal Admit Card from above provided direct link.
WBJEE 2019 Result
After the WBJEE examination, WBJEE Results will be declared on 02-07-2019 by the Board. Final result will be published in the form of Rank Cards, which will contain all relevant ranks and total score.
WBJEE 2019 Counselling
- A separate notification with details of counseling/seat allotment and admission will be published in www.wbjeeb.in shortly after publication of result. Only those, eligible for counseling, will be able to participate in it.
- The candidate has to appear himself/herself. No other person is allowed to appear for counselling and admission on behalf of the candidate.
Get Here Complete: Counselling Schedule
How To West Bengal JEE Online Apply?
- First of all, applicants will have to visit WBJEE Official Website of West Bengal Joint Entrance Examinations Board i.e. www.wbjeeb.in.
- After reaching at official web portal, you may hit on "WBJEE" link from top menu bar for WBJEE Notification.
- Look up for the application form link for the West Bengal Joint Entrance Examinations.
- Now read the whole details from WB JEE Notification that will appear on the screen.
- After reading WBJEE Notification, hit on link of WBJEE Online Registration and fill all the details that are required.
- Thereafter, use WBJEE Login id to fill West Bengal JEE Application Form.
- After that upload the required documents and your scanned photographs.
- Pay the application fees and complete the whole applying procedure.
- Once the whole process is completed hit on the final submission tab.
- At last, get printout of filled WBJEE Application Form and keep it safe for future need.
Know Here: How To Get Admission In Engineering Colleges?
WBJEE 2019 Imp Dates
|WBJEE Notification Dates
|Starting of WBJEE Online Application Form
|Last date to fill WBJEE Online form, pay application fee and download confirmation page
|Availability of correction window
|23-01-2019 to 25-01-2019
|Download of WBJEE Admit Card
|WBJEE Exam Dates
|Publication of WBJEE Result
For Any Query Regarding Exam:
Controller of Examinations, West Bengal Joint Entrance Examinations Board
AQ-13/1, Sector –V, Salt Lake City, Kolkata-700091
Examination Helpdesk:-1800-3450-050, 03323671149, 59, 99.
Email: Link in www.wbjeeb.in
Candidates may open this Official Link to get more information about WBJEE Notification 2019 and stay in touch with us on our web portal for getting latest updates about WBJEE Application Form 2019.
Something That You Should Put An Eye On
|Top 50 Engineering Colleges In India
|List Of Entrance Exam in India
|Education Loans for Students
|Top Colleges in India
|Scholarship in India
|Best Career Opportunities
|List of Fake Universities
|UGC Approved University List

subset: commoncrawl


text:
CW Botanicals
Charlottes Web 17mg/1ml Dog Tincture
Regular price £64.95
Formerly known as Charlotte's Web PAWS, this whole-plant hemp extract features a full spectrum of hemp-derived cannabinoids. Now in a pump, our oil is a perfect addition to meals or a boost at snack time. And now with our unflavored and chicken-flavored options, any picky palate is sure to be pleased.
Dogs, like humans, have an Endocannabinoid System to help them maintain overall wellness, and CBD - along with hemp's many other naturally occurring compounds - can help support good health for your canine best friend.


text:
Key Facts
Founder of Lady's Hope Dog Rescue
Office dog whisperer
Yvonne Devereaux
SR Operations Manager
As a seasoned Senior Project and Program Manager, Yvonne has planned, scoped and executed diverse complex digital marketing and advertising campaigns, programs and projects, live and virtually, across the US for Fortune 500 companies, as well as startups. This includes: team, client and vendor management; scheduling, budgeting and tracking; and creating and evaluating process. Yvonne creates and maintain positive relationships with the teams at Cognition, including supporting our vendors and clients using leadership, collaboration, negotiation and education.
She enjoys bringing clarity to ambiguity in a fluid environment, and keeping the team smiling.
Key Facts
Founder of Lady's Hope Dog Rescue
Office dog whisperer
Our Team
SR Developer
Vern Briggs
Associate Director of Design, Brand Communications
Vanessa Ruiz
Lead Account & Project Manager
Royal Stuart
Technical Project Manager / Front-end Developer
Jeremy Wilson
Lead Developer
Bryce Benson
Jr Designer, Brand + Interactive
Lindsey Jensen
Designer, Brand + Interactive
Rachel Simons
Jr Medical Illustrator + Animator
Dani Bergey
Presentation Specialist
Jenn Luft
Designer, Information Design
Maureen McLennon
SR Operations Manager
Yvonne Devereaux
Science & Medical Writer
Elizabeth Hjort
Associate Director of Design, User Experience
Jonathan Cook
Medical Illustrator + Animator
Regina Milner
Associate Director of Science Storytelling
Jared Travnicek
Sr Designer, Brand + Interactive
Amanda Grage
Co-Founder, Chief Design Strategist
Kristine Johnson
Sr Certified Medical Illustrator + Animator
Inessa Stanishevskaya
MScBMC, CMI
Co-Founder, Director of Science Storytelling
David Ehlert
Associate Director of Design
Chad P. Hall
Designer, Brand + Interactive
Karlie Grasle


text:
Mark D Underwood1,2* and Victoria Arango2
1Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
2Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, USA
Received Date: March 29, 2018; Accepted Date: April 19, 2018; Published Date: May 01, 2018
Citation: Underwood MD, Arango V (2018) Disconnect between Brainstem Serotonin Neurons and Prefrontal Cortex Serotonin Receptors in Suicide. Acta Psychopathol 4:12. doi: 10.4172/2469-6676.100168
Serotonin neurotransmission is widely reported as reduced in suicide attempt and completion. Evidence suggests reduced serotonin innervation of the prefrontal cortex and homeostatic upregulation of postsynaptic 5-HT1A and perhaps 5-HT2A receptors in suicide. However, in the brainstem, we have previously found more tryptophan hydroxylase serotonin biosynthetic enzyme and more serotonin in suicide decedents suggesting serotonergic hyperfunction, but also more autoreceptor binding that could result in reduced neuronal firing. We sought evidence of a disconnect between the brainstem and prefrontal cortex examining the serotonin transporter (SERT) and 5-HT1A receptor in the dorsal and median raphe nucleus and SERT, 5-HT1A and 5-HT2A receptor binding in prefrontal cortex and in anterior cingulate cortex postmortem.
Suicide decedents (n=11) and controls (n=18) died suddenly minimizing agonal effects and had a postmortem interval ≤ 24 hour. Autoradiography was performed in right hemisphere coronal sections at a pre-genual level and in transverse sections through the brainstem.
In controls, there were correlations between DRN and MRN SERT and 5-HT2A receptor binding throughout prefrontal cortex, and between DRN and MRN 5-HT1A receptor binding and medial and ventral prefrontal cortex. In suicide decedents there were no such relationships.
The absence of correlations between brainstem source serotonergic neuron function and receptors on target neurons in prefrontal cortex in suicides suggests a disconnect that may contribute to suicide neuropathology.
Suicide; Postmortem; Serotonin; Prefrontal cortex; Dorsal raphe nucleus; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor
Suicide attempt and completion has long been hypothesized to involve decreased serotonin (5-hydroxytryptamine, 5-HT) neurotransmission in the brain [1-4]. Less research has been done examining differences in the serotonergic neurons giving rise to the serotonergic innervation of the prefrontal cortex (PFC) in suicides, and if so, whether differences in those neurons are suggestive of altered neurotransmission or function in target regions.
Evidence for reduced serotonergic neurotransmission in the prefrontal cortex in suicide comes from several indirect lines of evidence including the cerebrospinal fluid concentration of 5-HT or its metabolite 5-HIAA [5-7], pharmacological challenge evoking 5-HT release or depletion [8-10] and direct measures from postmortem tissue such as receptor binding, receptor affinity and expression of serotonin-related genes [8,11]. MDD can be effectively treated clinically with serotonin selective reuptake inhibitors (SSRI), suggesting that the depressive symptomatology can be modulated by increasing intrasynaptic 5-HT levels, however, SSRI are not particularly effective at reducing suicide.
In vivo and in vitro methods have been used to image receptor binding in brain to examine the anatomical distribution of serotonergic receptors in suicide and nonfatal suicide behavior [12-14], and how regional brain binding patterns differ from psychiatrically normal individuals. The consensus that there is a serotonin system abnormality is a lot stronger than which brain areas are involved and the direction of the difference in binding [15-18] and explanations for discrepancies include heterogeneity of the patient population, small group sizes, small effect sizes and variability in outcome measures due to demographic variables including sex and age in live cases and also postmortem interval and brain pH in in vitro studies.
In the present study, we used postmortem brain tissue and sought to simultaneously examine the brainstem and the prefrontal cortex in the same brain using quantitative autoradiography, from data we have previously published, in both the prefrontal cortex and in the dorsal raphe nucleus in the brainstem, where the source 5-HT synthesizing neurons reside. We combined all available cases and examined binding results using three serotonin markers in multiple prefrontal cortical brain regions assayed from cerebral hemispheres for the serotonin transporter (SERT), the 5-HT1A receptor and the 5-HT2A receptor and of the SERT and 5-HT1A receptor in the dorsal raphe nucleus (DRN) and median raphe nucleus (MRN) in the brainstem.
The Division of Molecular Imaging and Neuropathology at the New York State Psychiatric Institute was the source of the brain samples. All procedures for the collection and use of brain tissue were approved by the Institutional Review Board for Human Use Considerations of the appropriate Institutions. All subjects died suddenly and had a postmortem interval (PMI, time of death to time of freezing of the brain) of 24 hours or less. The Coroner or Medical Examiner diagnosed the suicides (Table 1). Cases with an undetermined cause of death were neither included nor collected.
|Age (years)
|PMI (hours)
|Brain pH
|Controls (n=18)
|Suicides (n=11)
Note: PMI = Postmortem interval; S.E.M. = Standard error of the mean
p>0.05 for Age, PMI, Brain pH.
Table 1: Demographics.
Quantitative in vitro receptor autoradiography in postmortem human brain was done as described [19-22]. Sequential 20μm sections were used for [3H] Cyanoimipramine, [3H]8-OH-DPAT and [3H] Ketanserin binding in the prefrontal cortex, to label serotonin transporter sites, 5-HT1A and 5-HT2A receptors, respectively. In the brainstem, sections were collected, and pairs of near adjacent sections used with 1mm spacing throughout the rostrocaudal extent of the DRN. Preincubation in buffer was done to remove endogenous ligands and any possible exogenously administered drugs from the tissue and incubation was done with radioligand under optimal conditions determined elsewhere. Nonspecific binding was determined by incubations of adjacent sections with appropriate displacers (see below). Sections were then washed in incubation buffer at 4°C, briefly dipped in water, dried and transferred to a desiccator until dry and ready for loading into film cassettes for exposure. Dried slides were exposed to tritium-sensitive film (Hyperfilm, Amersham, or Biomax MS film from Kodak). Sections were exposed with slide-mounted tritium standards (American Radiolabeled Chemicals, Inc.) and films were developed (Kodak D-19) for 4 min at 17°C, rinsed briefly, and fixed (Kodak Rapid Fixer) for 5 min. The tissue sections were fixed in 10% buffered formalin and stained for Nissl with thionin or cresyl violet.
Autoradiograms were quantified using a computer-based image analysis system (MCID, Imaging Research, Inc.). First, shading correction is established by acquiring a blank field at medium luminance. The MCID system calculates the mean of this field and stores a pixel-by-pixel matrix of deviation values from the mean. These deviation values are used to correct each of the image pixels to achieve proportional shade correction. Images of standards are then calibrated to femtomoles of radioligand per milligram of tissue, providing density values in units of radioligand concentration, corrected for nonlinearities. Calibrated images of total binding and nonspecific binding are aligned on separate channels and linked. By outlining the areas of interest in the image of total binding, the computer simultaneously measures densities in both channels and provides the value for specific binding. Samples of receptor binding in a given brain region are calculated as an area- weighted average to produce one specific binding density measure for that region in that individual. The coefficient of variation between individual sections from one subject is generally less than 10%. At this anatomical level, samples were taken in BA8, BA9, BA46, BA45, BA47, BA11, BA12, BA24 and BA32.
[3H]Cyanoimipramine (CN-IMI) binding to serotonin transporter sites
Quantitative autoradiography of 5-HT uptake sites was performed as described elsewhere [19,20]. Total binding was determined with 0.4nM 3H-CN-IMI and nonspecific binding using 10 μM sertraline (Figure 1). Using our assay conditions, nonspecific binding is less than 20% of total binding [19].
[3H]8-OH-DPAT binding to 5-HT1A receptors
Quantitative autoradiography of 5-HT1A receptors was performed by our modifications [19,20] of the protocol of Hoyer et al. [23]. Slides were incubated with 2nM [3H]8-OH-DPAT and 100nM sertraline (to block binding to the 5-HT transporter). Nonspecific binding is determined by 1 μM 5-HT (Figure 1) and is approximately 10% of total binding [19,23].
[3H]-Ketanserin (Ket) binding to 5-HT2A receptors
Total binding was determined by incubation with 2nM 3H-Ket, 1 μM prazosin and 1 μM tetrabenazine. Nonspecific binding was determined with 1 μM mianserin (Figure 1) and is approximately 30-40% of total binding [23].
Statistical analyses
Statistical tests were done using SPSS (Version 24, IBM Analytics, NY) using procedures CORRELATIONS, REGRESSION and CTABLES.
In controls, SERT in the DRN correlated negatively with 5-HT2A binding in BA8 (r=-0.599, p=0.024, n=14), BA9 (r=-0.507, p=0.032, n=18), BA46 (4=-0.588, p=0.031, n=15), BA45 (r=-0.490, p=0.039, n=18), BA47 (r=-0.623, p=0.01, n=16), BA11 (r=-0.555, p=0.017, n=18), BA24 (r=-0.663, p=0.013, n=13) and BA32 (r=-0.514, p=0.035, n=17). SERT in the MRN also had a negative correlation with 5-HT2A binding in BA9 (r=-0.489, p=0.039, n=18), BA46 (r=-0.544, p=0.036, n=15), BA47 (r=-0.527, p=0.036, n=16) and BA11 (r=-0.491, p=0.039, n=18). There were no correlations between SERT in the DRN or MRN and SERT in any region in the PFC. This suggests that less SERT in the brainstem is associated with more 5-HT2A receptors in dorsal prefrontal cortex (Figure 2).
Figure 2: Summary of correlations between the amount of serotonin transporter and 5-HT1A receptor binding. Note that all but one of the correlations were observed in the controls. In controls, SERT in the dorsal raphe nucleus (DRN) and median raphe nucleus (MRN) was negatively correlated with 5-HT2A binding in the prefrontal cortex (PFC). 5-HT1A binding in the DRN and MRN positively correlated with medial prefrontal cortex.
In controls, 5-HT1A binding in the DRN positively correlated with 5-HT1A binding in BA47 (r=0.544, p=0.024, n=17), BA11 (r=0.493, p=0.038, n=18), BA12 (r=0.517, p=0.028, n=18) and BA32 (r=0.527, p=0.025, n=18). 5-HT1A binding in the DRN did not correlate with SERT or 5-HT2A binding in any region in the prefrontal cortex (Figure 2). 5-HT1A binding in the MRN had a positive correlation with 5-HT1A binding in BA47 (r=0.585, p=0.014, n=17), but not with SERT or 5-HT2A binding in any region.
In suicides, there was one statistically significant correlation, a positive one between 5-HT1A binding in the MRN and SERT in BA9 (Figure 2). There were no significant correlations between SERT or 5-HT1A binding in the DRN with any of the prefrontal cortex regions sampled (p>0.05).
Impaired serotonergic neurotransmission in the prefrontal cortex in suicide has long been hypothesized. We sought evidence suggesting that a potential contributor to the dysfunction in the prefrontal cortex was in the brainstem DRN and MRN where source serotonin-synthesizing neurons reside. We found several correlations between DRN and MRN SERT and 5-HT1A receptor binding and 5-HT2A and 5-HT1A receptor binding the PFC in normal controls, but only a single correlation in suicides. We and others have hypothesized that the greater density of postsynaptic 5-HT1A and or 5-HT2A receptor binding in prefrontal cortex reported in suicide decedents is homeostatic upregulation in response to reduced serotonin neurotransmission. In controls, we found correlations suggesting that reduced serotonin transporters in the brainstem are associated with more 5-HT2A receptors in the prefrontal cortex, supporting the contention that prefrontal cortex receptor levels are related to serotonin functional capacity in the DRN and MRN. However, in suicides we found no such relationships, and we believe this suggests a functional disconnect between the brainstem and prefrontal cortex may contribute to the altered serotonergic neurotransmission in suicide behavior.
Serotonin receptors in the prefrontal cortex
Some studies, though not all, in postmortem brain and live patients using PET find widespread deficits in SERT binding and increased 5-HT1A binding in depressed individuals and medication naïve depressed subjects and in suicide attempters [17]. Discrepancies in studies of serotonin receptor binding in vivo and in vitro can arise from differences in the ligand used, antidepressant treatment, and even seasonal variation in receptor density and body mass index [17,24]. Likewise, pharmacologic challenge of the serotonergic system results in a blunted neuroendocrine response [9] and CSF 5-HIAA is lower in depressed subjects, in proportion to lethality of nonlethal suicide attempters [25]. Taking the postmortem and in vivo evidence in depressed suicides and suicide attempters together, the weight of evidence suggests that hypofunction of the serotonergic system is associated with the suicide phenotype and reduced serotonergic neurotransmission contributes to suicide behavior.
We observed higher 5-HT1A receptor binding compared with controls in the ventrolateral PFC [19]. Differences in receptor binding in suicides may be related to associated psychiatric illnesses such as major depressive disorder. Parsey et al. have reported this using PET in three samples of MDD subjects and then in bipolar depression, remitted depression and in offspring of MDD [18]. In that paper it is also explained that he could match the results from other seemingly discrepant studies by changing the method for calculating PET binding [18].
Using an antagonist, we found no evidence for a significant role of the 5-HT2A receptor in suicide [22]. The literature reports increased [22,26], decreased [27] and no change [28] in 5-HT2A receptors in suicide, and both increased and decreased binding in MDD in vivo [17]. One possible explanation for the discrepant reports is the use of agonist versus antagonist ligands for measuring binding. LSD is an agonist that has been used and detected increased binding in suicide [22,29], while ketanserin is an antagonist and has been used and detected increases or no change in suicides [24]. Furthermore, discrepancies in reports in the literature could be attributable to the confounding effects of antidepressant treatment, family history of alcohol abuse and even body mass index [17].
The brainstem
In contrast to the hyposerotonergic neurotransmission in the prefrontal cortex, in the brainstem, specifically in the DRN and MRN where 5-HT synthesizing neurons are located, there is conflicting evidence of hyperserotonergic and or hyposerotonergic function. We find greater tryptophan hydroxylase 2 protein, the rate-limiting biosynthetic enzyme for 5-HT in brain, in the DRN of depressed suicides [30,31]. Likewise, we find an increase in the amount of TPH2 mRNA expression per neuron as well as the total number of serotonin neurons in depressed suicides [30,32,33]. It is not only an increase in the capacity of the DRN neurons to synthesize 5-HT, we measure more 5-HT and more of the metabolite 5-HIAA [34]. In contrast, there are fewer 5-HT1A inhibitory autoreceptors that would functionally result in less autoinhibition of 5-HT neuron firing in caudal DRN, while in rostral DRN there are more autoreceptors which could reduce DRN firing [20,35].
We hypothesize that a deficit in serotonergic transmission in the prefrontal cortex gives rise to complex and conflicting regulatory responses in the source 5-HT synthesizing neurons in the brainstem (Figure 3). We hypothesize the lack of "normal" relationships between the amount of SERT sites and inhibitory autoreceptors in the DRN and MRN and postsynaptic 5-HT receptor subtypes in the PFC in suicides indicates a "disconnect" between the brainstem and the prefrontal cortex that we hypothesize is part of the pathobiology leading to suicide behavior. Our finding in the current study of associations in controls but not in suicides, we believe, supports this hypothesis. The upregulation in tryptophan hydroxylase and 5-HT synthesis may be offset by local 5-HT release acting on inhibitory autoreceptors to reduce serotonergic neurotransmission in the prefrontal cortex in suicide. We find more 5-HT1A receptors in the rostral DRN in depressed suicides [35], as well as more 5-HT [34]. If so, the decrease in 5-HT1A receptors in the caudal DRN [35] indicates local plasticity and less autoinhibition from locally released 5-HT. Alternatively, local release of 5-HT might be sufficient to shut down 5-HT neuron firing despite the abundant 5-HT DRN neurons. This raises the possibility that there is less 5-HT release in the forebrain because local 5-HT release in the DRN acts on 5-HT1A autoreceptors and reduces DRN neuron firing which results in less 5-HT release in the prefrontal cortex.
Figure 3: Schematic diagram illustrating a proposed hypothesis for plasticity and compensation in the serotonergic system in suicide. In the prefrontal cerebral cortex in suicides, there is a decrease in serotonin transporter (SERT) and more 5-HT1A and 5-HT2A receptor binding compared to non-psychiatric controls. The dorsal raphe nucleus provides the serotonergic innervation to the prefrontal cortex, where 5-HT acts on 5-HT1A receptors predominantly on excitatory pyramidal neurons in the outer cortical layers and on 5-HT2A receptors in deeper cortical layers with reduced serotonergic neurotransmission having an overall effect of disinhibiting neuronal activity and reducing normal levels of behavioral inhibition. In the dorsal raphe nucleus, there is not less 5-HT, as would be hypothesized by the reduced innervation of the cerebral cortex, but there is more 5-HT and more tryptophan hydroxylase 2 biosynthetic enzyme. It is hypothesized that there is an anatomical and functional disconnect between the source 5-HT neurons in the brainstem and target neurons in the prefrontal cortex.
Disconnect between the brainstem and prefrontal cortex in suicide
The serotonergic receptor findings of reduced SERT and increased 5-HT1A and 5-HT2A receptor binding in the prefrontal cortex of suicides are consistent with less serotonin or a hyposerotonergic forebrain, most likely the consequence of less serotonergic innervation from the dorsal and median raphe nuclei that give rise to the serotonin-synthesizing neurons that innervate the cerebral cortex. Reduced serotonergic function has been a long-standing hypothesis in the etiology of suicide. Data supporting this reduced serotonergic function hypothesis come from diverse studies and methodologies, including live patients and postmortem cases. The SERT is located on axons and axon terminals and are an indication of serotonergic innervation and intrasynaptic serotonin levels [36]. Less SERT binding in the prefrontal cortex in suicides therefore suggests less innervation and/or less intrasynaptic 5-HT. 5-HT1A and 5-HT2A receptors in the prefrontal cortex are located predominantly on cortical interneurons. We believe the most parsimonious explanation for more 5-HT1A and 5-HT2A binding in prefrontal cortex is receptor upregulation in response to less 5-HT release. 5-HT1A receptor activation results in hyperpolarization and a decrease in neuronal activity in PFC [37], on pyramidal neurons and cortical interneurons. An increase in 5-HT1A receptors in PFC suggests an inhibition of excitatory output from cortical regions that mediate executive function and behavioral restraint. We hypothesize that reduced cortical activity may be a top down cause of a reduction in behavioral restraint and an increase in the risk for suicide behavior. Multimodal imaging studies of structure and connectivity in suicide attempters [2], such as those used in connectomic studies [38,39], support this model. We did not find any associations with the 5-HT2A receptor in the prefrontal cortex of suicides, raising the possibility that the lack of difference is part of the neuropathology associated with suicide. Our serotonergic receptor forebrain findings are consistent with less serotonin, or with a hyposerotonergic forebrain and less serotonergic innervation from the raphe nuclei (Figure 3).
Correlations are not any indication of change or causation. Postmortem studies can only provide a cross-section of conditions present at a single time point, in this case at the time of death. We previously reported receptor differences associated with suicide and alcoholism and found some differences in the serotonergic system associated with diagnosis of alcohol use disorder [40]. We used as many brains as we had data available for and while for some tests the group size was notable, especially for a postmortem study, in other measures the group size was small. Findings with larger group sizes increase confidence in disease-related observations while also increasing the ability to detect differences. The larger group sizes provide more statistical power for detecting differences. Lack of reproducible findings in the postmortem literature of suicide has been attributed to effects of antemortem factors, postmortem interval, toxicology, neuropathological assessment, clinical diagnosis, brain region identification and even freezer storage time [15]. Analysis of a larger number of cases raises the possibility of including cases without regard to comorbid diagnosis which would introduce greater variability, and while this is not surprising, the gain of having a sample that is more representative of the general population, there is an inherent limitation in alternative approaches using only highly matched samples that may not be representative of either nonpsychiatric comparison controls or to the suicide groups.
Future work should involve in vivo brain imaging of the SERT and 5HT1A for suicide, and the 5HT2A receptor to validate these findings, and more importantly, to include cases with major depression and alcoholics to determine the extent that any of these differences are contributory to pathology or a consequence of the pathology or homeostatic changes suggestive of future potential therapeutic approaches to the prevention or treatment of suicide.
We acknowledge Suham A. Kassir for performing the autoradiography experiments. We are grateful to Virginia L. Johnson (autoradiography analysis) and Manuela Douglas (brain sectioning and staining) for their technical expertise. Mihran J. Bakalian performed all the statistical analyses.
This work was supported by grants from the National Institute of Mental Health and the National Institute on Alcohol Abuse and Alcoholism (MH40210, AA09004, MH62185 and AA11293) and the Diane Goldberg Foundation. Some of the brain samples and their psychiatric characterization and storage were funded by NIH grants MH90964 and MH64168.
Drs. Arango and Underwood declare no conflicts of interest.


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TORONTO - Portland Timbers captain Will Johnson has undergone successful surgery in Toronto to stabilize a fractured tibia and fibula in his right leg.
The Major League Soccer team made the announcement a day after the Portland midfielder and Canadian international was stretchered off in the first minute of a game against Toronto FC.
Johnson is expected to miss approximately six months.
The injury occurred just moments after kickoff as Johnson and Toronto FC defender Mark Bloom collided legs while going to the ground for a loose ball near midfield.
Johnson was taken off the field after a lengthy delay. Toronto midfielder Michael Bradley, a close friend of Johnson's, stood by as the Portland player was treated before leaving on a stretcher and taken to hospital.
There was no call on the play.
Johnson has made 29 appearances for the Timbers this season, recording six goals and two assists while earning MLS all-star honors for a second consecutive year.


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By Tuna Taşan-Kok, Guy Baeten
This e-book argues that the innovations of 'neoliberalism' and 'neoliberalisation,' whereas in universal use around the entire diversity of social sciences, have to this point been regularly missed in making plans thought and the research of making plans perform. supplying insights from papers awarded in the course of a convention consultation at a gathering of the organization of yankee Geographers in Boston in 2008 and a few commissioned chapters, this booklet fills this important hiatus within the learn of making plans. What the case reports from Africa, Asia, North-America and Europe incorporated during this quantity have in universal is they all demonstrate the uneasy cohabitation of 'planning' – a few form of country intervention for the betterment of our equipped and usual atmosphere – and 'neoliberalism' – a trust within the superiority of industry mechanisms to prepare land use and the inferiority of its contrary, kingdom intervention. making plans, if whatever, can be visible as being in direct distinction to neoliberalism, as whatever that are meant to be rolled again or perhaps annihilated via neoliberal perform. to mix 'neoliberal' and 'planning' in a single word then turns out awkward at most sensible, and an outright oxymoron at worst. to confess to the very lifestyles or epistemological danger of 'neoliberal making plans' might sound to be a complete hand over of kingdom making plans to marketplace superiority, or in different phrases, the straightforward popularity that the administration of structures, delivery infrastructure, parks, conservation parts and so forth. beyond the revenue precept has reached its limits within the 21st century. making plans to that end will be diminished to a trifling facilitator of 'market forces' within the urban, be it mild or authoritarian. but even with those contradictions and outright impossibilities, planners function inside of, give a contribution to, withstand or mood an more and more neoliberal mode of manufacturing areas and areas, or the revival of profit-driven adjustments in land use. it truly is this contradiction among the serving of personal profit-seeking pursuits whereas really looking the general public betterment of towns that this quantity has sought to explain, discover, examine and make feel of via a collection of case stories protecting quite a lot of making plans concerns in numerous nations. This e-book lays naked simply how spatial making plans capabilities in an age of industry triumphalism, how planners reply to the overruling revenue precept in land allocation and what's left of non-profit pushed developments.
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This e-book analyzes making plans from a postmodern point of view and explores substitute conceptions in response to a mixture of postmodern considering and different fields of social conception. In doing so, it exposes the various limits of postmodern social conception whereas supplying another notion of making plans within the twenty first century.
Housing Policy Matters: A Global Analysis
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In particular, scientists and engineers working on the upcoming WiMAX standard have resolved a number of problems that had bedeviled existing wireless protocols such as WiFi. The prospect of reaching gigabit speeds was now being mentioned, and other quality of service issues as well as lower costs of installation are being addressed. To the extent that these predictions are realized, the WiMAX protocol may well offer an effective wireless solution to the broadband gap, especially for smaller towns and communities across the United States.
The second symposium, addressing semiconductors specifically, dealt with speed at which semiconductor technology develops, which is described by Moore's Law. That topic is critical to telecommunications technology, the focus of the current symposium, just as it is to the development of technologies related to computing. 29 30 THE TELECOMMUNICATIONS CHALLENGE The subject of the third symposium in the series, which was held about a year after that on semiconductors and for which a report was yet to be published, was computers.
Since this technology has a completely different capability than traditional landlines when it comes to voice quality, cost, and reliability, he predicted that it will bring about a generational change in voice communications. Louis Mamakos of Vonage (a company that has introduced VoIP to commercial markets in the United States and elsewhere) cited two sources of opportunity that arise with VoIP: One is through sharing infrastructure, which comes from chopping up audio into packets and transmitting it over an existing packet-based 12See remarks by William Raduchel in the Proceedings section of this volume.


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Faculty are invited to participate in the University of North Dakota's 2016 Summer Commencement Ceremony on Friday, Aug. 5. The ceremony will begin at 3 p.m. in the Chester Fritz Auditorium. Your participation in this important university event will provide a very strong message of support for your students and their families.
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ETSON has signed several cooperation agreements
ETSON / JRC of the EC
ETSON partners closely work together with various international, European and regional partners and networks
International bodies
Several international expert bodies issue authoritative findings and recommendations on safety related topics. The advice provided by these bodies is an important input to the development of the IAEA safety standards and other international standards. It is frequently incorporated in national safety-related laws and regulations and ETSON observe and apply it.
A number of these bodies are listed below:
IAEA - The International Atomic Energy Agency (IAEA) is the world's central intergovernmental forum for scientific and technical co-operation in the nuclear field. http://www.iaea.org/
ICRP - The International Commission on Radiological Protection (ICRP) is an independent, international organisation which helps to prevent cancer and other diseases and effects associated with exposure to ionising radiation, and to protect the environment. http://www.icrp.org/
ICRU - The International Commission on Radiation Units and Measurements (ICRU) has established since its creation in 1925 international standards for radiation units and measurement. http://www.icru.org/
OECD-NEA - The Nuclear Energy Agency (NEA) is a specialised agency within the Organisation for Economic Co-operation and Development (OECD), an intergovernmental organisation of industrialised countries. http://www.oecd-nea.org/
- CSNI Committee on the Safety of Nuclear Installations
- CNRA Committee on Nuclear Regulatory Activities
- MDEP Technical Secretariat functions for the Multinational Design Evaluation Programme
TSO Forum - The objective of the TSO Forum (TSOF) is to encourage open dialogue and sharing of scientific and technical information among TSOs worldwide. http://gnssn.iaea.org/Pages/TSOF.aspx
UNSCEAR - The UN Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) was established by the General Assembly of the United Nations in 1955. Its mandate in the United Nations system is to assess and report levels and effects of exposure to ionizing radiation. http://www.unscear.org/unscear/en/index.html
WHO - The World Health Organization (WHO) is the directing and coordinating authority for health within the United Nations system. http://www.who.int/en/
European networks and stakeholders
ENEF - European Nuclear Energy Forum (ENEF) is a platform to promote broad discussion among relevant stakeholders on opportunities and risks of nuclear energy. https://ec.europa.eu/energy/en/events/european-nuclear-energy-forum-enef-plenary-meeting
MELODI - MELODI is an European Platform founded in 2010 and dedicated to low dose radiation risk research. http://www.melodi-online.eu/
ENSREG - European Nuclear Safety Regulators Group (formerly known as: European High-Level Group on Nuclear Safety and Waste Management) http://www.ensreg.eu/
IGD-TP - The mission of the IGD-TP is to build confidence in the safety of geological disposal and encourage the establishment of waste management programmes. http://www.igdtp.eu/
NUGENIA - NUGENIA is an association which acts as the body in charge of coordinating at EU level the implementation of the R&D within its technical scope: GEN II&III R&D as described in the Strategic Research Agenda (SRA) of SNETP, and related cross-cutting topics http://nugenia.org/
SNETP - The Sustainable Nuclear Energy Technology Platform (SNETP) promotes research, development and demonstration of the nuclear fission technologies necessary to achieve the goals of the Strategic Energy Technology Plan (SET-Plan), European strategic plan to accelerate the development and deployment of cost-effective low carbon technologies. http://www.snetp.eu
WENRA - WENRA is a network of Chief Regulators of EU countries with nuclear power plants and Switzerland as well as of other interested European countries which have been granted observer status. http://www.wenra.org/
Other regional Networks
ANNuR - Arab Network of Nuclear Regulators – https://gnssn.iaea.org/main/ANNuR/Pages/default.aspx
ANSN - Asian Nuclear Safety Network – ANSN - http://ansn.iaea.org
FNRBA - Forum of Nuclear Regulatory Bodies in Africa – https://gnssn.iaea.org/main/FNRBA/Pages/default.aspx
FORO - Ibero-American Forum of Regulators – http://www.foroiberam.org/welcome


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SCHENECTADY, N.Y. - The Agriculture & New York State Horse Breeding Development Fund has published its list of eligible stallions for the 2020 harness racing breeding season. The list includes 39 registered standardbred stallions, of which seven are new this year.
The full Stallion Directory, featuring pedigrees, career statistics and earnings of the eligible stallions, will be available online in the coming days. Hard copies of the Stallion Directory will be mailed to owners of mares and available through the Fund upon request.
The new stallions in 2020 are:
Courtly Choice
Lightning Storm
Made By Design
Major Moe
Pride Master
Semalu Express
Stella's Phella
Eligible stallions are those stallions have met the ownership or leasing requirements of the Fund and were registered by the Jan. 1 deadline.
Copies of the 2020 New York Stallion Directory can be requested by calling 518-388-0178 or emailing firstname.lastname@example.com.
The racing schedule and updated conditions for the upcoming New York Sire Stakes racing season are available at www.nysirestakes.com. The NYSS "Day of Champions" will be held Saturday, Sept. 12 at Yonkers Raceway.
About the Agriculture & NYS Horse Breeding Development Fund:
The Agriculture & NYS Horse Breeding Development Fund is a public benefit corporation established in 1965 by the Laverne Law (Laws of New York, Chapter 567 of the Laws of 1965). The mission of the fund is to promote agriculture through the breeding of Standardbred horses and the conduct of equine research within the state. To carry out its legislative mission, the Fund administers the New York Sire Stakes races, Excelsior/State Fair Series races, and County Fair Races.
Jason Politi | Baker Public Relations


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—— Nikola
—— Roger
Product Details:
Payment & Shipping Terms:
|Trenbolone Hex
|Other Name:
|White Or White Crystalline Powder
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1 . Basic Information :
Chinese name: Qunbolon cyclohexyl methyl carbonate
Chinese synonym: Qunbolone cyclohexyl methyl carbonate; Qunbolone cyclohexyl methyl carbonate (steroid); Qunlong ring methyl carbonate; Group Boron ring methyl carbonate
English name: Trenbolone cyclohexylmethylcarbonate
English synonym: cyclohexylmethyl 17-beta-hydroxyestra-4,9,11-trien-3-one carbonate; ESTRA-4,9,11-TRIEN-3-ONE;trenbolone cyclohexylmethylcarbonate;17β-[[(Cyclohexylmethoxy)carbonyl]oxy ]estra-4,9,11-trien-3-one;carbonic acid cyclohexylmethyl (3-keto-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a ]phenanthren-17-yl) ester; cyclohexylmethyl (13-methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl) carbonate ; Estra-4,9,11-trien-3-one,17b-hydroxy-, cyclohexylMethylcarbonate (8CI);4-CDC
CAS No.: 23454-33-3
Molecular formula: C26H34O4
Molecular weight: 410.55
EINECS number: 245-669-1
Related Categories: Steroids; Vitamin Ingredients; Steroid and Hormone; Pharmaceutical Raw Materials; trenbolone series; Chemical properties; Pharmaceutical intermediates; Chemical and pharmaceutical intermediates; Medical research
Mol file: 23454-33-3.mol
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text: Need Help? Call Us! (800) 252-1578 CART MENU Open menu ICD University Store Toggle search bar What can we help you find? Submit search CART Webcasts Upcoming Webcasts On-Demand Webcasts Continuing Education AAPC AHIMA Books ICD-10 Coding CPT Coding Clinical Documentation Risk Adjustment AMA Coding References H3.Group Resource Library Optum360 Coding & Documentation Books Specials Talk Ten Tuesdays Coming up on Talk Ten Tuesdays Listen to Podcasts News Latest News Free eNews Sign Up Ten Ready Poll Subscriber Portal Nav Menu 2 Nav Menu 3 Nav Menu 4 Nav Menu 5 Nav Menu 6 Nav Menu 7 Nav Menu 8 Home > Books > 2020 ICD-10-CM Documentation Trainer Price: $209.95 Publisher: DecisionHealth Availability: September 2019 Product Code: IPBPDC20 Quantity: Description No other resource brings coders and physicians together to empower them for ICD-10 documentation success like DecisionHealth's 2020 ICD-10-CM Documentation Trainer. Packed with pages and pages of detailed checklists and proven tools, this book will ensure you meet all the additional ICD-10-CM documentation requirements that are critical to ICD-10 implementation success. Organized by chapters mirroring the structure of your code book, you'll speed through this book together and have the opportunity to test each other's knowledge of key points you'll learn along the way with exercises, real-life coding scenarios and quizzes. This single documentation training source has all the tools necessary for an effective documentation analysis and a corrective action plan. Features include: UPDATED! FY2020 ICD-10-CM codes and guidelines included so you have the most current information when coding. Detailed, full-page anatomy illustrations—for better interpretation of clinical notes and coding with greater specificity. Checklists to identify new documentation elements for categories, subcategories and/or codes—take the guesswork out of documentation with these step-by-step guides. CDI checklists—identify common documentation deficiencies faced when coding COPD, Pneumonia and Sepsis/SIRS. Scenarios showing required documentation—see where the documentation will appear in common coding scenarios based on real-life healthcare encounters. The correct codes are included with any applicable guidelines explained. End of chapter quizzes—dive right into coding practice with the conditions discussed in each chapter. Glossary of Medical Terminology Related Resources CPT Coding Essentials for Anesthesiology and Pain Management 2021 CPT Changes 2021: An Insider's View ICD-10-CM 2021: The Complete Official Codebook The Social Determinants of Health: Case Management's Next Frontier Price: $184.95 Price: $84.95 Price: $110.95 Price: $155.00 ICD-10-PCS 2021: The Complete Official Codebook 2021 ICD-10-CM Expert for Physicians with Guidelines CPT 2021 Professional Codebook and CPT QuickRef App Package Vascular Interventional Radiology Coding Charts Price: $110.95 Price: $114.95 Price: $156.95 Price: $149.00


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- 54Shares
I don't know what happened to me today, i just felt a roller coaster ride of emotions. It started early in the morning, hearing the song Dance with My Father, I started crying.
Perhaps, I missed Papa more than ever. The memory that we shared during my younger years vividly playing in my mind. My family will always tells me that I am Papa's pet.
Dear Papa,
I am here, longing for your embrace. It's been 28 years since the last time I hugged you. I was devastated for your passing. I even questioned everything, why so soon? Why God allows family to be separated by death in early year. I was scared and lost. The family almost "breakdown" because of your passing but because of the help of your friends and family we managed to survived.
I am glad I have a countless father -daughter memories to cherish even though you gone soon, my heart was full of good memories of you. Whenever you lifted me in your strong wide arms and enveloped me in the warmest tightest hug possible, I know you will always the man I can take refuge.
The man that always inspires me was you. I remembered how you became my hero, my comfort every time I felt sad or hurt. You made me felt special and your princess. I missed those days that I had to do things together, watching movie in Virac Theater, and had dinner at Grace Restaurant. How you bribe me every time I've got star/very good and perfect score in the exams. You encouraged me to reach for the star and you have faith on me that I could fly high with my chosen path.
Your friends will tell me that I got most of my personality from you. You are the tower of my strength. I become a warm-hearted soul and caring because I saw how you respected and valued others. No one will argue if I say, I am just like you, stubborn but compassionate, hardheaded but very family oriented. I have now realized the true depth of your presence through my life.
Fast forward
I am now a wife of a responsible & caring man and starting a family. Just like you, he is a good provider and have a caring heart for the family. Please continue to guide us and our Angel.
- 54Shares


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On this edition of Eastern Standard:
- The hepatitis A outbreak in at least a dozen Kentucky counties is now the worst in the nation. We'll hear about the response from the food industry.
- WEKU's Cheri Lawson visits with author Silas House about his new book, Southernmost.
- We'll peer around the future's next corner for a look at what's ahead in manufacturing.
- A new project in West Virginia to make good use of coal waste - while a new health study finds the surge in cases of black lung disease especially concentrated among coal miners in Central Appalachia. We'll have reports from Brittany Patterson and Jeff Young of the Ohio Valley Resource.
- Becca Schimmel of member station WKYU on a new study detailing the Kentucky wage gap.
- And, something completely different - yet, completely familiar.


text: The innate characteristics of a Virgo are the main topic of the day, my readers, just as you've asked! Each of us may don't have much about the Virgo people in real life. Nonetheless, it doesn't mean that we cannot point out the general traits of the Virgo natives from birth. A closer perspective about the super-interesting Virgo characteristics helps understand why the Virgo is of your interest now. We attempt to list out five positively cool traits of the Virgo-born. #1: Independent The … [Read more...] about Positively Good Characteristics Of A Virgo


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The Prima Donna Seamless Satin Bra is low-key but elegant. This underwire bra has molded cups for a smooth finish. Its sturdy cups support and lift the breasts and create a gorgeous round shape.
- Underwire for support
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DescriptionThe Anita Maternity Underwire Nursing Bra is both beautiful and utilitarian. You'll be astonished at how easily you'll be able to unclip this bra using only one hand. The cups are pre-formed and seamless but do not have lining, pockets or padding. The jacquard pattern on the cups is a pretty touch and keeps you from sacrificing luxury for comfort and usability.
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The Anita Top Comfort Safina Soft Cup Bra is the best in comfort for every day wear. Its great feel and pretty embroidery will keep you reaching for it as your go-to bra. It stretches all over, thanks to stretch panels that move with you for a customized fit. The underbust band has inverted V-shape to accommodate the actual shape of the body, so nothing feels as though it is digging into you.
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The Anita Top Comfort Clara Soft Cup Bra is made with a special blend of fine-knit, woven microfibers that offer outstanding support while still remaining flexible and lightweight. The undercup is lined for additional support as well, where it is needed most.
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The Rosa Faia Twin Underwire Bra is made of breathable microfiber fabric for a smooth, seamless look. Designed to be invisible under clothes, the double-layered cups are contoured to create a natural breast shape. Bigger sizes are made with a hidden layer of support through the sides and the straps are reinforced.
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Style: 5490


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South Downs artists in the spotlight
Posted: 3rd March 2017
AppArt's annual Art Exhibition & Sculpture Trail will see many local South Downs artists taking part.
Foremost among these is sculptor Philip Jackson. Philip has an international stature and his very many public commissions throughout the UK are testament to this. Mahatma Gandhi in Parliament Square, The Queen on Horseback at Windsor and Alex Ferguson in Manchester are just a few examples.
As well as opening the AppArt exhibition, Philip's Venetian-inspired sculptures will be on display indoors and on the sculpture trail.
Christopher Cole is a prolific painter and he runs many painting courses in the area. His landscapes are vivid and detailed and capture the atmosphere of their settings. Tuema Pattie is now painting with the Sussex Group of painters and her abstract work is bold and moody.
Ruth Barrett-Danes' collagraph and drypoint pictures are vivid and exquisitely executed. Sculptor Geoffrey Slinton works his magic with galvanized wire and his cheerful chickens, descending seagulls and runner ducks are cleverly created. Jon Barrett-Danes creates ceramic creatures large and small - his rats look mischievous and his sheep graceful as they adorn the grass. Filomena Forte's work has an Italian influence and she works in a variety of materials. Alex Archbold casts in glass and flora and fauna are her dominant subjects.
The Exhibition & Sculpture Trail at Prior's Field School, Godalming will be open every day from Saturday 1st April to Easter Sunday 16th between 10 am to 4pm. Admission is free and visitors will be able to view about 500 indoor exhibits and also explore the Gertrude Jekyll-inspired gardens and see over 100 large sculptures in a tranquil and picturesque setting.
For further information, go to: www.appartonline.co.uk


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It seems, June 2018 is far, however Indian Institutions are gearing up for the preparation for the upcoming academic session. Premier Instituions are finalising their academic recruitment needs and would start their upcoming session focused hiring process by January end.
For Progressive professional institutions, this is the time to evaluate their academic strengths and weaknesses and based on that they adopt academic hiring practices best suited for their institutions.
Kalpesh Banker, Managing Partner at EduShine, wrote an article for India Today on "Hiring Trends for India Higher Education Institutions". It would help Institutions in fine tuning their academic hiring plans with the trends.
To read more: http://indiatoday.intoday.in/education/story/hiring-practices-in-india/1/1080732.html


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CDC. Methodologic changes in the Behavioral Risk Factor Surveillance System in 2011 and potential effects on prevalence estimates. Preventive Services Task Force recommended in August 2014 that obese and overweight adults with additional CVD risk factors be offered or referred to intensive behavioral counseling interventions to promote a healthful diet and physical activity.
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White Cedar Octagon Walk-In Picnic Table
Family sized and classic white cedar log styling make this picnic table a great addition for your patio, back yard, lawn, or gazebo. All custom made in the USA by the Pennsylvania Amish, and made with durability and craftsmenship in mind
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Cedar Log Checking: All cedar logs, over time may be prone to a process called checking. More information.
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- Some assembly is required.
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- White Cedar Log
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- Octagon


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Both patients and new medical students can easily be scared at the thought of an anal examination. An anoscope, however, is a tool that makes this process generally quick and painless. I've put together this guide to anoscopy and the tool that makes it possible–the anoscope–to help ease your comfort with this procedure.Anoscope BasicsAn anoscope […]Continue reading
Even if you don't know much about colonoscopies, you probably know that they aren't much fun. I'm not here to convince you otherwise. However, I do want you to know that colorectal cancer screening is absolutely imperative. These tests have the potential to save your life because they can catch cancer early on or before […]Continue reading


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JSA advises and represents several clients in the services space across diverse sectors. Services remains one of the dominant and key drivers in the growth of Indian economy. The continuing effort to improve the rankings of doing business in India is likely to boost the activities in the services space. The introduction of the goods and services tax is also intended to provide the necessary impetus for its growth. With the benefit of sector specific focus and domain knowledge, the advice provided by the firm in the services space encompasses sectors like information technology including e-commerce, hotels and hospitality, financing, real estate and healthcare.
Last Updated on 7th March, 2019
© 2019 J. Sagar Associates All Rights Reserved.


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6 Ways Yoga Can Help the Planet This Month
As climate change activism heats up this month (the Global Climate Strike is taking place from September 20-27), yoga studios, teachers, and organizations are joining the call for a healthier environment and sustainable future. Eoin Finn, founder of Blissology and the EcoKarma foundation, encourages yogis to recognize their connection with nature and make preserving the planet a lifestyle.
"We are one with the environment" says Finn. "Take breathing for example. Breathing brings the outer world inside of you. We take air into our bodies and it passes through us via our blood - it's hard to separate where physiology ends and the environment begins. Our job as yogis is to create experiences and rituals in our practice where we feel this interconnection."
Amy Ippoliti, another renowned yoga teacher and environmental activist, pushes for action above all else. "We are deeply interconnected with all life on earth and the practice of yoga only heightens that awareness. Our actions need to be consistent and relentless. Let's be clear."
Here are six ways yogis can get involved in climate activism.
See also The Rise of Eco-Friendly Yoga Studios


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Positivity and Newton's 3rd Law: Why We Should Smile When We Are The Customers
Although I keep blogging about food, I remain as one of the most boring person in Singapore when it comes to having lunches. Back in the army and prison, when lunch was provided, everybody around me was looking for an excuse to lunch out, while I was very contented with what I was served in the messhall. Even now, 2 years after I hung up my uniform for the corporate world, my lunch option is usually very simple:
The mixed rice stall, a.k.a point-point-rice (ppr), at the in-house canteen.


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Hello guyyyys! How are you? How is your summer break going? I want to know all about your adventures, tell me everything below!!
I'm back today on the blog talking about a great topic : audiobooks! I'm one those people that don't listen to audiobooks. Yeah…I never even tried once so how on earth could I talk about something that I never tried ??! Guilty as charged but yeah I'm still going to talk about it and I'm going to try to explain why I think audiobooks are just not a good fit for me.
I'm not saying audiobooks aren't great because seriously they are such an awesome invention! It's a convenient alternative to old-fashioned reading. That way, reading can become more accessible to everyone. It keeps your hands free to like do some gardening or running. It's great during a long journey if you get carsick while reading. And it does wonders for your eyes. I mean, you're on the computer all day long at work, it can get tiring for your eyes. With audiobooks, you can just sit, relax and take it all in.
So why the hell don't I listen to audiobooks? Well…here's why :
🌪 1. I can't seem to stay focused more than 30 seconds
When I'm listening to the radio like a show or something that is not music, my mind keeps wandering elsewhere. I think I need to actually see to retain information. With audiobooks, I would be rewinding non-stop. Did I miss something crucial? What was the name of that character? Wait…what happened just now?
🌪 2. I absolutely love to touch my books
Yeah…that sounds a bit creepy but that's true. I like to hold my books, to feel the pages between my fingers and to smell them (weirdo!). Sometimes the cover is really soft and there are some pretty graphics along the pages, a book is such a pretty object!
🌪 3. I feel like the voice will influence my enjoyment of the book
Does that makes sense? If the voice is like soft or more hoarse, I think it can change my perception of the story. What if I really struggle with the narrator? What if I don't like their voice? It's so subjective, but I feel like I won't enjoy the book as much.
🌪 4. It seems longer to finish a story
With audiobooks, the story seems to never end. I don't know but I like to see where I'm at in the story (with my eyes!). Am I in the middle? Or at the start, still waiting for the plot to be more developped? Am I close to the end? Is there going to be a twist? 20 hours to finish a book, it seems scary!
🌪 5. It's rather expensive
For that price, I'm not going to lie…I'd rather have something physical.
In all, I think I just like to be in control. I never liked to listen to people read to me. I want to be actor and not stay passive. I think it's a whole different experience that way.
What about you? Do you listen to audiobooks? What do you like about it?
Do you prefer reading physical books? Did you ever try audiobooks? If not, why?
Let's chat in comments 💬
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