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Today, the daily tasks needed to maintain one's home have been simplified without sacrificing efficiency by way of automation. Tech-savvy homeowners are no doubt rejoicing that there are plenty of control systems that feature Smart technology, all of can contribute to the upkeep of your living spaces, both inside and…Read More
Make Space in Your Condo with Strategic Furnishings
Condominium living is the perfect fit for singles, childless couples of all ages, and retirees downsizing from larger homes. But despite the many advantages of condo living, there's no denying that these residences offer less room than conventional homes. As a result, some condo residents mistakenly think they have to…Read More
Vital Top Qualities of an Electric Valve Actuator
Your electrical valve actuator has actually seen far better days. This would certainly make certain that the actuator that you would certainly be obtaining would certainly be an ideal fit that would certainly make sure that your A/C system is running on a constant and effective basis. There are numerous…Read More
Why You Should Hire a Professional Gutter Cleaning Service
Many people don't value the importance of roof cleaning or believe that it's not necessary to hire a professional gutter cleaning Wigan service. The buildup of dirt, debris and moss on your roof are more than just eyesores, as they trap moisture, weigh down your roof and can easily cause…Read More
Minimalist Dining Rooms Can Attract Attention Too
Most of us believe that interior designing focuses on sprucing up your dining rooms with the maximum amount of decor. However, this is not always necessary. Having a dining room with minimalist home decor can also be possible. Hence, we need to pay attention to the fact that it is…Read More


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This mix is done using our proprietary waterfall technique. It is made with 3 colors, solid white, blue and teal pearl. Picture of pen is for reference only and not included in purchase.
Some mixes are made to order and require up to a 5 day turnaround to fulfill the order. Communication will be provided if there is any delay with your order.

subset: commoncrawl


text: Any time God wants something done, he starts by picking a leader. And he picks different leaders for different tasks. Moses was a teacher to an infant nation, David a soldier in a period of war, Solomon a poet in an age of ignorance, Isaiah a visionary in an era of uncertainty, Paul an unrelenting preacher at the dawn of the gospel's advancement. And the list goes on. But why was Abraham chosen? What can we learn from God's choice?


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Need a reading, mandala or some jewelry? Check it out.
Near Seattle Washington: A picture taken by a 12-year-old Kirkland girl during the holiday week in December surprised her family by capturing a mysterious object.
The girl, her family and her 15-year-old friend were staying at cabins overlooking a river in Winthrop when the incident occurred.
At sunset, the girl was experimenting with a new digital camera she had received as a gift.
The girl and her 15-year-old friend took pictures of each other, snow on the trees and snowflakes at night. At one point, they saw an object moving and tried to capture it on camera.
Web Design by: Genesis Creations Entertainment
©Copyright 2002-2020 San Diego Paranormal. Copying content or pictures from this site is prohibited. Copying of any portion of this site for commercial use is expressly prohibited.


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Our good deals
Not to be missed
History and Heritage
Sport and Mountains
The Crossroads of Tourist routes
With the family
Our region
Audio guides
Le Pays Rhin Vignoble Grand Ballon
Les visites virtuelles
Noël à Guebwiller en Alsace
Bed and Breakfasts
Holiday rentals
Groups and Mountain shelters
Camper van sites
Hébergement insolite au pied du Grand Ballon
Programme of events
Places to visit
Leisure activities
Outdoor activities
In winter
Guided visits
Practical information
Depending on the weather
Around and about
Book your activities
Farms and inns
Pâtissiers, salon de thé
Local products
Les vins d'Alsace
Half-day visits
Day visits
All inclusive holidays
Small group special offers
Specific request
The charm of Bed and Breakfasts !
Practical: Download the list for guest house availability for the next four days here
"Located at the heart of the vineyard, the bed and breakfasts of Marie-Thérèse and Gérard have an Alsatian style and overlook the Bollenberg, the...
Located at Linthal, close to the Ridges and Wine Routes, between Markstein Station and Petit-Ballon, at the heart of Ballons des Vosges Park,...
Our guest-room...
situated in the center of Lautenbach , a small typical village of the alsacian "Florival", forseen for two persons (35 m2) and...
In the Park of Ballons des Vosges, 14 km from the Ridges Road, Claudie and Yves welcome you in a quiet place in Linthal in their renovated house...
Guest house in town: three sophisticated bed and breakfast with individual bathrooms with toilets, TV into each room. There is a common living room...
The Kleissler family (Patricia and Frédéric) suggests you having your stay at the heart of this small village, in 2 spacious guest rooms of a...


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I joined Wintingo casino about 2 weeks ago and everything was fine until it came to make a withdrawal (my first withdrawal of £136).
I requested the withdrawal on Thursday 29 August and was immediately advised that I needed to provide ID documents, pictures of bank cards and a utility bill. I immediately posted these to the email address provided, but I have no untility bills, so sent a letter from the hospital. I requested that the casino notified me if this was all okay.
It is now the 5th September and I still haven't received any contact and my withdrawal is still pending. That's 8 days just left hanging with no communication.
I have been proactive in those 8 days, contacting the live support about 5 times and asking them what is going on. Each time they say that the' Banking Dept' is another department and highly classified, but I shouldn't worry as everything will be fine and I'll be contacted by them. But everything isn't fine.
Sometimes they say the banking dept is closed, other times they tell me to write to them directly using an email address they have supplied. I have wrote to the banking dept 3 times via email, but still no reply.
So what does one do?
I am losing my patience, the service is poor, the ethics are questionable when they freely taking my deposits, but leave me hanging not only with my withdrawal, but also the stage before. Why are some casinos being allowed to get away with this shoddy service?
I have stuck to the rules, deposited my money, but why can't the casino provide simple communication, player protection and pay out my winnings?
I am sure there will be all manner of well written, highly polite emails coming back now form the casino, but beware fellow gamblers as I am being unfairly treated here.. After all, the main reason we play is to win, not to throw our money away.
I would like a response from the casino and I would like my withdrawal granted.


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Driving Crash Courses Manchester
Driving Crash Courses:
The modern world moves very fast with many people no doubt struggling to fit extra activities into their everyday schedule. If you're trying to learn how to drive but are stuck for time, perhaps you should look into a Driving Crash Course
Sometimes enrolling in a regular course can be a bit of toil to fit in with your hectic 9-5 and will eventually take its toll. With no free time to do what you like or relax, you may find yourself quickly becoming exhausted or missing a social life as whatever free time you do have will be behind the wheel.
This is not a worry with a crash course. Most people pass within a week or two of their first lesson and are then straight on the road. It doesn't need to be staggered over months and it does not need to consume your free time. As soon you get in the driver's seat for the first time, you are not far away from being fully-qualified. We appreciate time may be of the essence so here at PassersHub Driving School Manchester we do the best we can to get you on the road as quick as we can.
Our courses are well-known for high pass rates from students, this comes down to the vast experience of the Passers hub team of fully qualified DVSA approved instructors and how they work with you step by step and make the whole experience comfortable and enjoyable for you.
Don't hesitate to contact us or request a free callback for more information.
******Best Driving Crash Courses Manchester with Passers Hub Driving School ******


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Management of energy infrastructures
Ezentis Energy Services
Electricity, water, oil, gas, mining.
We at Ezentis are experts in the operation, maintenance and construction of power distribution networks and electricity substations, and we offer industrial services in all corners of the energy sector. We are your logistics partner in the field of energy.
We are your logistics partner in the field of energy.
Ezentis Energy Services
Operation, maintenance and construction of power distribution networks and management of substations and electricity grids.
- Technical consultancy and specialist engineering.
- Installation and maintenance of transport and distribution lines, substations and transformer platforms.
- Installation of substations and transformer platforms.
- Smart Grid.
- Energised services on high-voltage lines.
- Civil and Electromechanical Engineering Works.
- Commercial electricity management projects in the areas of reading, apportionment, outages and reconnection, standardisation of domestic meters and power theft.
- Construction and preventive and corrective maintenance for public lighting networks.
- Industrial and shopping centre installations: power and lighting.
- Smart network.
- Installation of charging points for electric vehicles.
- Sanitary water systems.
- Water networks.
- Sewerage networks.
- Environmental protection.
- Corporate GIS projects.
- Basic and design engineering.
- Construction and maintenance of tanks.
- Compressor plants.
- Process Studies.
- Installations of piping and facilities.
- Vessel, flow, piping and pump calculations.
- Oil pipelines – Gasoducts – Polyducts.
- Heat and exchanger calculations.
- Structure calculation.
- Maintenance of transformers and power feeders.
- Battery conditioning.
- Corporate GIS projects.
- Design of gas transmission and distribution networks.
- Project management, engineering and construction of networks.
- Corrective and preventive maintenance with corrosion protection and refurbishment.
- Domestic installations.
- Installation and replacement of meters and connections.
- Meter reading.
- Integrity control and systematic leak tracking.
- Corporate GIS projects.
- Construction, installation and maintenance projects for telecoms systems, both fixed and wireless.
- Electricity installation, either industrial or administrative, transformer stations and platforms, signalling and alarms.
- Lighting systems.
- Construction, installation and maintenance projects for installations.
- Pumping and water treatment station works.
- Geographical Information Systems (GIS).
Principal energy clients
Other business lines
Work with us
We seek worthy, capable and enthusiastic people.
We seek people who can integrate into an innovative, growing company where they can work on unique projects.
Are you Ezentis?


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With all the attention Linux has been getting recently, especially in the form of attention from major hardware vendors, the impact of Walmart's decision to bring to market a $200 Linux PC (Everex TC2502 Green gPC w/ Via C7-D Processor) should be surprising.
The customers seem to love this computer, if you go by the product reviews: 56 reviewers gave it an overall 4-star rating. There were only two buyers who left one-star reviews, complaining about lack of performance or inability to run Windows XP (not true, since the hardware was certified as XP-compliant).
But what really surprised me was the fact that the item is listed as "out of stock", with a note explaining how you can "Step up to the Everex GC3502 for Double the Memory and Windows Vista Basic" instead. For an extra $100, you get: the exact same computer, but with an extra 1/2 gig of RAM and
Microsoft Windows Vista Home Basic.
Which is kind of funny, because you wouldn't be able to run Vista on a PC with only a half-gigabyte of RAM.
Anyway, RAM's pretty cheap these days. You can buy a full gigabyte from Walmart online for $40 or so. Which means you'd be paying roughly $60 for that low-end edition of Vista. In other words, you pay a 25% "Vista tax" on a $240 PC.
The big question is this: does Walmart make any money selling a $200 PC for $200, or is it just a loss-leader to get people in the store and sell them $240 PCs for $300?


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Rotorua Duck - Tarawera and Lakes Tour
Rotorua Duck - Tarawera and Lakes Tour
Rotorua Duck Tours is the first, and still the only, company in New Zealand to provide the unique and exciting opportunity to explore a special part of New Zealand in an authentic amphibious WWII landing craft.
Where else can you jump on a genuine amphibious WW2 vehicle and tour a city as well as its lakes without even leaving your seat? When it comes to what to do in Rotorua, it's hard to go past our popular Tarawera and Lakes tour! Discover the history of the people and the landscapes that shaped our region while exploring some of our most beautiful scenery.
First, you'll journey through the central city before heading straight out to Lake Okareka for your first 'Splashdown', nestled in the heart of a vibrant little community. You'll then head through a magical, untouched scenic reserve before arriving at Lake Tikitapu (Blue Lake), Rotorua's most recreational lake. You'll see untouched beauty at this magical little local gem.
From Lake Tikitapu it's off to the main event, Lake Tarawera, right at the base of the mighty Mt Tarawera volcano. This volcano erupted in 1886, changing the history of Rotorua forever. You'll learn in depth about this devastating eruption and the effects it had on our land and our people.
Unique vehicle, unique destination, unique history – there's no better formula for an unforgettable experience!
Tour Info
|Tour Type:
|Guided Nature Tours & Walks
|Rotorua to Rotorua
|From (NZD) $95 per person
|90 minutes
|Tour Code:
|Fully guided commentary
|Transportation from the town centre
|Transportation amphibious WW2 vehicle
Tour Departures
- Frequency: Daily
- Departure Point: 1241 Fenton St Rotorua
- Departure Time: Summer (October to April) Weekdays: 3.30pm Weekends: 9.55am Winter (May to September) Weekdays & Weekends 2.15pm
- Duration: 90 minutes
- Closed: Christmas Day
Important Information
- Minimum of 2 passengers required to operate
- This tour must be booked at least 72 hours in advance of travel
- Confirmation of this product will be received within 24 hours of booking, subject to availability
- Tour is operated in English unless otherwise stated
- Complete operator information, including opening times and local contact telephone numbers are included on your e-voucher
General Information
- Child discounts apply to children aged between 3 – 16 years inclusive (0 – 2 are free if sitting on a lap)
- Bring a hat, sunscreen, sunglasses, walking shoes and your camera. In Winter months we advise dressing warmly – jackets and warm clothes recommended.
Booking Form: Rotorua Duck - Tarawera and Lakes Tour
Rotorua Duck Tours is the first, and still the only, company in New Zealand to provide the unique and exciting opportunity to explore a special part o... Read More
Are you a return customer? Click here for information on our Loyalty Program.
Click on each area to view more information.
Upgrade this tour by adding one of our carefully selected optional tours & activities or go ahead and request a quote to guarantee your spot.
You can also create your dream holiday by using our custom itinerary planner.
Create your Custom Itinerary


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Today we'll function a up to date house named Villa in Bilthoven in Utrecht, the Netherlands. This has B,seven hundred sq. meter constructing property which is situated in a reasonably inclined road in Bilthoven within the Dutch province of Utrecht. This has agency constructing plan necessities which decided the idle alignment of the rooms. Well, allow us to check out the superb and distinctive options of this villa that the designers utilized and carried out so as to provide you with a brand new masterpiece. It was stated that the home seems reasonably closed off southwards in the direction of the 12-meter lengthy forecourt. It is in distinction to the north aspect through which consists of the backyard which the dwelling quarters open up. The rooms are properly lighted which in appropriate climate present the choice of extending the dwelling area onto the terrace. Well, let's discover extra of the totally different areas of this Charming Villa in Bilthoven via the pictures under.
The white palette used within the exterior creates a spotless and modest type.
Take a take a look at the quantity and dimensions revealed on this constructing.
Exquisite furnishings along with the inexperienced timber completely enhances with the clear panorama within the backyard.
With using glassed supplies within the partitions, doorways and home windows, the equipment and furnishings set within the inside are all the time seen.
The array of timber enhances the pure magnificence within the exterior which connects the home to nature.
The clean edges and features of this constructing are properly displayed right here.
Exceptional design and elegance of the doorway are additionally mirrored right here.
This chandelier fashions an incredible connection between the inside and the stunning backyard outdoors.
Even within the toilet, the put in LEDs to intensify the floral tiles within the wall.
In the morning, the house owners might benefit from the glowing view of the outside.
The house owners needed to have at the very least sufficient area for the Jacuzzi that they could make the most of even at night time.
The LED put in inside and out of doors the bed room could be very helpful that underlines the stylish and fashionable look.
The eating desk are properly set right here that the householders can take the complete benefit of the recent air within the backyard.
Even at night time the enthralling appeal of this villa stands out.
The white palette is persistently used on this exterior of the home together with that of the storage. As you'll be able to see above, the focus on the bottom flooring is the open kitchen the place the eating and dwelling areas are grouped. The higher flooring is separated into areas that are meant for the youngsters and the mother and father. This home design is flawlessly created by the Clijsters Architecture Studio. We hope that when once more we've given you one other set of inspirational concepts and elegance of a up to date home that you could be use on your dream home sooner or later.


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Philip Wesley Gates & Jamison Edgar, Queer History in Motion
KST Presents
In this movement-based workshop, we will use our bodies to investigate histories found within the archives of the Pittsburgh Queer History Project. Through collaborative prompts and exercises, participants will explore how queer lives and memories move between archival storage, digital systems, and the human body. This is a chance to get an inside look at the processes used to create Nearest Neighbors, as well as discovering new perspectives on how we might connect respectfully to the past in order to open ourselves to possible futures.
The workshop is open to anyone of any ability or background. Come with curiosity and an open mind.
Don't miss Philip Wesley Gates & Jamison Edgar's Freshworks Residency Presentation of Nearest Neighbors on Friday, October 4th at 8:00pm.
Photo by Jacquelyn Johnson
Pay What Makes You Happy! Registration for this workshop is available at any price. Simply choose the level that makes you happy—or name your own!
Registration open NOW!


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1. Where do you ship?
We are based in Singapore but we ship worldwide too!
2. How much is shipping fee?
We provide Free Express Courier Service (worth $4.99) for all orders above $80! For orders below $80, you can opt for Normal Mail (3-5 working days) at $1.99 or Courier Service (1-2 working days) at $4.99.
3. What is the difference between Normal Mail and Courier Service?
Normal mail does not have a tracking number hence it will be difficult to retrieve if lost. Courier Service would provide tracking as well as notifications as to when would your parcel arrive.
*Not liable for lost normal mails
4. How long does shipment take?
All items will be shipped out within 1-3 days upon purchase. After which, local purchases will take 2-5 days to arrive and international purchases will take 10-15 days to arrive.
5. What is the returns & exchange policy?
We take pride in providing the best quality products in the market for our customers. We currently do not offer any returns or exchange.


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New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
Cultured cells subjected to oxygen deprivation have been shown to undergo anomalous DNA synthesis, which can result in DNA overreplication and the generation of cellular variants [Rice, G. C., Hoy, C. & Schimke, R. T. (1986) Proc. Natl. Acad. Sci. USA 83, 5978-5982]. In the present study, murine tumor cells were exposed to severe hypoxia and then tested for their ability to form experimental metastases. Upon reoxygenation, cells transiently, yet dramatically, increased their metastatic potential. Flow cytometric analysis confirmed that hypoxia and reoxygenation induced cell cycle perturbations and DNA overreplication in these tumor cell lines. Fibrosarcoma cells with overreplicated DNA isolated by fluorescence-activated cell sorting proved to be highly metastatic, although cells with 2-4 times the haploid DNA content in populations treated with hypoxia were also markedly more metastatic than oxic populations. These results support the hypothesis that hypoxic conditions existing in regions of solid tumors promote cellular heterogeneity and tumor progression.


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Orange Juice Blog Publisher and Editor-in-Chief Vern Nelson has it out for Anaheim's Lorri Galloway since she accused him of sexual assault months back.
Vern continues to undermine Galloway's credibility when he's really the one with the problem. Nelson left a comment on this post at the OJBlog; he writes:
Cunningham's latest post blares the deceptive title "Galloway raises $117,000 for campaign" – that sounds like a lot, a sure sign of popularity!
But read on and it's actually only 17K she raised – the rest is a 100K loan she made to herself.
It's always been curious how gently uncritical the supposedly conservative Klepto-Scribe has been of her – one of myriad grounds for suspicion.
But beyond that, how the hell does she lend her campaign $100,000 while her Eli Home employees are taking turns going without paychecks?
Crazy stuff…"
This prompted a message from three employees of The Eli Home to this blog.
We have all been proud employees of the Eli Home for over 5-7 years. We have always been paid our salaries and The Eli Home does not owe us any money. All other employees will gladly verify the same thing. We will share our pay stubs to honest inquirers.
Jose Vargas, Director of Development
Yolanda Bermudez, Executive Assistant
Keta Rubalcava, Store Cashier
Nelson's credibility for telling the truth is shakey at best. On Valentine's day, Nelson has a court date at 8AM to turn over any firearms he owns stemming from his April 2016 arrest for his fifth DUI which is classified as a Felony. For a guy with no clear means of stead gainful employment, if he owns guns I'm not sure how he could afford them and do you want someone with his drinking problem possessing a firearm in a home where small kids are present?
A blog comment yesterday here suggested Nelson was sentenced to three years in jail. That's true, as it turns out.
Nelson was sentenced on January 16, 2018, and the sentence was stayed and he's on three years probation and must enter an 18 month program for chronic alcohol abusers. Additionally, he needs to spend 10 days in jail and another 4 days in jail in lieu of a fine (which was unspecified). It's not clear if Nelson can serve his jail sentence concurrently. And it's also not clear if he's served it yet or when he will.
Here's the paperwork:
Nelson owes the employees of Eli Home an apology for his false statement. He owes Galloway an apology for much more.
And when it comes to credibility, I'll take Lorri Galloway's lifetime of public service as an elected official and the executive director of a battered women's shelter over a 5 time convicted drunk driver who was called "lecherous" to women by his own managing editor.


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Unschool with youtube learning through videos
We Unschool with youtube and learn through videos. Some kids are great at doing reading stories and doing workbook sheet but other hate them like my two kids. The best way to protect your kids is by using a parent approved streaming videos app. The kids search for things they are interested in learning, and this is great way to encourage their passions. Belle thinks that is would be fun and he might see weird Continue reading


text: tag:blogger.com,1999:blog-6454299534973486652.post3327804282555375857..comments2020-09-24T00:21:30.263-04:00Comments on Following The Thread: Me Made May: a beginningMelwykhttp://firstname.lastname@example.com:blogger.com,1999:blog-6454299534973486652.post-36045018055326904722019-05-12T11:01:00.437-04:002019-05-12T11:01:00.437-04:00I can't knit or crochet so I wouldn't be w...I can't knit or crochet so I wouldn't be wearing any warmly made memades like you have! I admire that talent. I'm thinking that after this month I might have to spend the next month making more of my favourites.Melwykhttps://firstname.lastname@example.com:blogger.com,1999:blog-6454299534973486652.post-84860006981026754332019-05-12T03:49:19.780-04:002019-05-12T03:49:19.780-04:00Well I have been camping all month so far and have...Well I have been camping all month so far and haven't been able to think about wearing hand made ... apart from warm scarf, hat and socks, all knitted by me. Maybe once home, I will look what I have in my wardrobe and what I actually wear so I have a focus for future garments. Sarahttps://firstname.lastname@example.com:blogger.com,1999:blog-6454299534973486652.post-17189346415784284342019-05-09T20:51:04.422-04:002019-05-09T20:51:04.422-04:00Yes, I've found that now that I'm paying m...Yes, I've found that now that I'm paying more attention I'm also looking at the patterns I pick out to see if I would really wear that silhouette before I invest time in making it. It's interesting so far this month to see which items that I'm naturally gravitating to.Melwykhttps://email@example.com:blogger.com,1999:blog-6454299534973486652.post-76237390908694814242019-05-09T11:18:03.451-04:002019-05-09T11:18:03.451-04:00This is what MMM does for me too... I get up daily...This is what MMM does for me too... I get up daily and just get dressed...but I also end up paying more attention to what I like wearing (or don't like), what works and doesn't, what works together, etc. Super fun. KS_Sews (Dressmakingbacles)https://firstname.lastname@example.com


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In this age of unemployment and underemployment, employees fully engaged in the work place and those seeing new career opportunities are facing countless challenges. They fear losing their jobs or that big promotion. They are dealing with stagnant wages and raises that don't come through. Sometimes they deal with less than ideal managers, co-workers, subordinates and clients. And we can't forget dealing the global market.
And then there are the insurmountable odds of finding new employment with obstacles that didn't seem to exist just a decade ago.
So it is no wonder, people are turning to books to develop the skills to make them stand out and shine as a true asset in the workplace. One book is Anita Agers-Brooks book First Hired, Last Fired- How to Become Irreplaceable in Any Job Market.
In First Hired, Last Fired Agers-Brooks, uses passages from the Bible inspire and help employees of all kinds to make them completely invaluable in the workplace and thrive and grow whether they are the boss or a subordinate.
Now, a lot of advice in this book is just plain common sense (or at least should be) to a majority of people no matter their religious leanings. Agers-Brooks is a conservative Christian and I'm a liberal who was raised Roman Catholic but now a church-going Unitarian Universalist. But I definitely agree with the author we should have such characteristics like a strong work ethic, integrity, a mostly positive attitude and sense of reliability and responsibility. I also appreciate what I call the 4 Cs-Compassion, Creativity, Curiosity, and Common Sense.
First Hired, Last Fired is laid out in several chapters with characters as both employees and managers dealing with not only work challenges but also facing challenges at home. In one part, Agers-Brooks shows these characters in less than ideal lot. In the second part, Agers-Brooks shows these characters in more positive way using passages from the Bible on how to make their work and personal lives better, therefore, making them also irreplaceable in the workplace of their choice.
As I read this book I found the stories rather fantastical and Agers-Brooks writing style verges a bit over the top. She really loads on the purple prose. She tries a bit too hard to fit various people from the Bible to fit her characters' situations. For the most part, it's all about God being the sole way of making things work out to sheer perfection in any and all workplace situations. It was as if God (especially from the conservative Christian viewpoint) is a fairy Godfather who will grant everyone's wish, not bringing in the challenges we face in that have nothing to do with the real world of sexism, racism, homophobia, classism, and all kinds of bigotry, not to mention a corporate culture where selfishness and greed are considered virtues, not vices.
I hate to come across like a hater. I truly believe Agers-Brooks means well. Furthermore, she's been an employee and as someone who has her own business, she's spent time dealing with challenges as a boss and leader. She does know her stuff. I've been an employee, but I've also acted as a manager and a leader, and at times I've often looked to my faith to guide me in certain work situations. But I also know some things can't worked out using religious teachings whether one is using the Bible, the Torah, the Koran, or other faith-based ideas.
Now, without a doubt, I'm probably not the ideal audience for First Hired, Last Hired considering my more liberal and progressive leanings. But to those who share Agers-Brooks more religious and right winged POV, First Hired, Last Fired might make for ideal reading.


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Our 2020 accommodation listings offer a large selection of 2,477 holiday lettings around Solomos Museum. From 910 villas to 449 houses, find unique self catering accommodation for you to enjoy a memorable stay with your family and friends for a long holiday or a weekend break.
Yes, of course. HomeAway.co.uk has 910 Villas near Solomos Museum. Our other popular types of holiday rentals near Solomos Museum include:
But you can also enjoy a great stay in one of our other holiday rentals including Studios and more.
Yes, you can select your preferred holiday accommodation with pool among our 1,205 holiday rentals with pool available near Solomos Museum. Please use our search bar to access the selection of self catering accommodations available.
Yes, HomeAway.co.uk offers a selection of 2,477 holiday homes to book directly online and 1,732 with instant booking available near Solomos Museum. Don't wait, have a look at our self catering accommodations via our search bar and be ready for your next trip near Solomos Museum!


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Crossing a border, or boarding a plane or any number of other situations might involve someone asking you for your "I.D."
Usually this is thought to be short for "identification". but it's possible that in fact it might come from the Commonwealth military term "Identity Disc".
While the Americans used the term dog tag, Canadians and other Commonwealth forces were issued "Identity-Discs" or "I Discs" or perhaps simply "I.D's", In any case, now the Juno Beach Centre Association as part of its 75th events has launched the "Identity-Disc" (dog tag) fund-raising campaign.
Scott Entwistle is the special projects coordinator for the Juno Beach Centre Association.Listen
The concept of identifying soldiers can be traced back to Roman and Spartan times. For almost a century however, military personnel of various countries were issued identity discs. There were to provide identity in case the person was killed. There were either two discs, or one that was doubled and would be broken in half, and both carried the person's name, number, rank if an officer, and religion, and blood type in case of severe wounds and unconsciousness.
One would be left with the body to ensure proper identification, the other turned in so the person would be recorded as killed.
The Juno Beach Centre Association has created an I-Disc campaign to honour the 5,500 Canadians killed in the Normandy campaign.
As part of their fund raising to ensure the future operation of the important Juno Beach Centre itself in Normandy, individuals or groups can buy the I-Discs to honour one of the fallen. Each of the discs represents one of the fallen Canadians. Family, relatives, or friends of a particular fallen member can choose discs representing that person, while others can simply request a disc to honour any of the fallen Canadians.
The Juno Beach Centre in Normandy which tells the story of the vital Canadian contribution to victory, will be the site of important commemoration ceremonies on June 6th, the anniversary, and the focal point for a variety of events leading up to the anniversary and immediately following it.
Additional information
- Juno Beach Centre
- Canadian Soldiers.com (Michael Dorosh): detailed history on Identity Discs
- MilArt: Clive Law: Identity Discs in the Canadian Army
- Veterans Affairs Canada: D-Day and Normandy campaign
- Information about I-Disc campaign: email@example.com phone at 1-778-872-1466


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Pretty in Pink for Yasmine
A cake collaboration to remember and celebrate the life of Yasmine, a very special little girl. Aged 5, Yasmine developed a brain tumour and battled against all odds for five months, embracing each day and never complaining. Sadly it wasn't a battle she could win. Ten years after her passing, we remember her.
Have a lovely weekend.


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DJI Osmo Action Camera In-Depth: Taking on GoPro
COW Library : Cinematography : Tobias G : DJI Osmo Action Camera In-Depth: Taking on GoPro
The DJI Osmo Action is DJI's first GoPro-like action camera. It shoots crisp 4K video at 60 FPS, and super slow motion at 240 FPS at 1080p, also with support for HDR and terrific RockSteady image stabilization. It's waterproof of course, and especially interesting: TWO LCD screens to make it easy to see what you're shooting from every angle. VFX guru and filmmaker, Surfaced Studio's Tobias G puts the Osmo Action through its paces and tells all about what he likes and doesn't, with lots of sample footage for you to judge for yourself!
As Tobias notes in the video, this is NOT a sponsored production, but comes out of his own interests as a filmmaker, having purchased the camera for himself. The link below is an affiliate link for Tobias at Amazon, where you can buy your own while supporting his efforts.
DJI OSMO Action Cam Digital Camera at Amazon
Unable to find videos that were both educational AND entertaining, he started to create his own style of 'edutainment' tutorials online. He enjoys sharing his enthusiasm and passion for filmmaking and visual effects with anyone who is willing to put up with his 'special' type of humour.
For any business enquiries, please contact firstname.lastname@example.com
You can also follow Tobias here:
And since so many people have asked about my gear:
Main Camera - http://amzn.to/2rRkGzg (Canon 5D Mark III)
Main Lens - http://amzn.to/2rRfX0M (Canon EF 24-70mm II USM)
Vlogging Camera - http://amzn.to/2ssqgtm (Canon G7X)
Cheaper But Great - http://amzn.to/2seov29 (Canon S120)
Audio Recorder- http://amzn.to/2rhmz9U (Zoom H5)
Cheaper But Great - http://amzn.to/2r9zOpf (Zoom H2N)
Friendly disclaimer: Some of the links above are affiliate links and I will earn a small commission if you purchase through them. Thank you!


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HVP – High Voltage Products. High Voltage Experts.
HVP Global, LLC (HVPG) was created in 2006 to overcome a key business issue for smaller companies manufacturing high-voltage components: Overseas representatives and trading companies offer a mishmash of random products through staff poorly trained to sell high-voltage components; most of these companies act as order takers with little or no product marketing or promotion. On the other hand, wholly owned sales offices increase the cost of goods sold, reducing competitiveness, and have isolated product lines that reduce sales staff effectiveness and limit opportunities.
The HVPG solution: Selling overseas through an effective, fully trained, multi-product technical sales force with strong marketing and layered sales through a "one-stop-shopping" line card of complementary products.


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A packed evening of excerpts, inserts, works in progress and off the cuff experiments curated by Movement 12. A diverse collection of live performances, installation and film works from some of the most intriguing dance makers around.
Sunday 16 May 8pm, at the Pavilion Theatre, New Rd, Brighton. The evening includes:
· Passing Strange and Wonderful – a duet choreographed by Ben Wright for his company bgroup and performed by Keir Patrick and Lise Manavit.
· A solo choreographed and performed by Virginia Farman.
· A Readiness – a duet in progress performed by Abi Mortimer and Carrie Whittaker of Lila Dance.
· Myocyte – a solo created and performed by Miriam King.
· A new film by Marisa Zanotti.
· A solo created and performed by Augusto Corrieri.
· Small Talk – a new solo choreographed by Wendy Houstoun for Antonia Grove of Probe.
· an apportionment of light – an installation by CiCi Blumstein
· stand in – a film by Becky Edmunds with sound by Scott Smith.
· From Now On – a solo, created as it's performed, by Charlie Morrissey.
· The Clearing – a new duet choreographed by Charles Linehan. Created with and performed by Grieg Cooke andRahel Vonmoos.
Movement 12 is a group of independent dance artists based in and around Brighton who curate an international programme of artist-led opportunities and events. Look out for our new programme to be launched in Autumn 2010.


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At first, I was never into sports. I was the type of person who was more inclined to academic related things like the biology club, or the debate team. Usually people who are into these sorts of things are not so much inclined to anything athletic. The two different natures simply don't mix together, but I was proven wrong when I found out my passion for bowling. Since then I've discovered other sports through incidental circumstances rather than an intentional pursuance of becoming an actual athlete.
One day I was invited to a birthday party. This birthday party was held in a bowling arena. Deep inside I told myself, I came to the wrong party because I don't know anything about sports much less do I know anything about bowling. Fortunately enough my 86 year old grandmother was with me and she told me just visualize the ball hitting the pins. She told me to imagine an invisible line that the ball will follow ultimately hitting the pins. She was so convinced about this technique that I said what the heck let me give it a try. So, I imagined a red invisible line as it was my turn to roll the ball. I began to focus my energy on this imaginary line, and then I released the ball. Surprisingly, I knocked out all those pins! At this point, a wave of confidence overwhelmed me. My grandmother's technique was correct after all. I began to contemplate, what if use this technique of visualization with other sports. Later, I discovered that a lot of successful athletes in fact use the method of visualization to make their mark, or goal. As I became very interested with this technique of this realization, I began to research its benefits online. Apparently, there is a science to visualization incorporated in the field of sports.
Fortunately, that night I actually won the whole game. I was on fire! There's a saying that goes, the strongest person is not necessarily the one who always wins, but the person who thinks he can. That quote immediately stormed into my mind as a philosophical way of convicting me of this newfound belief, and interest regarding visualization and sports.
I began to experiment with this method with other sports. First, I started with basketball. I started to visualize the ball going into the hoop. This time I missed the shot however, the more I visualized the more I began to make more hoops then fails. At this point, I was definitely convinced that this technique of visualization was the answer to my weaknesses such as Sports. I may not be the best athlete, but I could still get away with it by just the utilization of the faculty of my mind which is visualization. Immediately, I thought I'd learn to skydive ca!
That was next on my to-do list. Come to learn more about it the use of visualization can not only be exclusive to be used in sports, but in fact it can be used in many other things. For example, the law of attraction, and manifesting your dreams.


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Reading R. Scott Rodin's excellent book has been one of my most refreshing and insightful experiences recently. It is a wonderful mosaic of teaching and examples of generosity gleaned from authors from around the world. The diversity of cultures shared and the skill of the editor in blending all the contributions into an unfolding of wisdom on this key subject is really encouraging.
The impacting stories illustrating many facets of generosity are thoughtfully chosen and blend seamlessly with the nuggets of teaching throughout the book. Much wisdom and practical insight is woven into the rich text.
However, that is not all... the thought-provoking summaries at the end of each chapter and the 7-day challenge at the end of the book are all very relevant and bring the reader into a focussed application mode. It is a book rich in principles and equally relevant potential ideas to increase one's understanding of generosity and its practical outworking in everyday life.
Am sure you will enjoy reading this special treasure....


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IDA Home | Action Center Home | Donate | Sign Up! | Tell a Friend
An Open Letter To Oprah Winfrey
Dear Oprah,
Please allow me to express my keen sorrow for the loss of Gracie. In your homage, you so perfectly captured her incandescent beauty and many gifts. Even though she was with you for what must seem only a moment, I imagine the life she had with you was a rapturous one, every day a sublime celebration. About five years ago, I lost my boon companion, Danny, a soulful hodgepodge of various canine breeds, and not a day passes without a Danny ache but, at the same time, there is always a flooding in of delicious memories of the dog for whom I was guardian and who miraculously transformed lives.
The visionary poet Rilke wrote that a good marriage is that in which each appoints the other guardian of his solitude. In our relationships with animal companions, we are the appointed guardians of their lives. You were Grace's devoted guardian.
I'm writing to you about language, a subject about which you care deeply—how words alter history, how movements are spearheaded by words. I'm writing about how words affect the forward march of animal rights and protection. (In Europe, the Swiss amended their laws to change the status of animals from "things" to 'beings.") I am writing about the transfixing power and importance of words and how they are the source of our very being. Words can stir us into action, mobilize nations. Words can also become weapons, arrows, enslaving, unconsciously encoding a certain kind of behavior. "Owner" has become such a word, with its patina of arrogance, compared to the more humane and humble "guardian." "Owning" a dog has become a diminishing thing, an impoverishing thing, above all obsolescent, a term that has lost its usefulness, for our beloved animal companions are not things, property, or commodities to be "owned" and thus discarded like an old chair.
Your choice of books, always in some way about justice, compassion, and truth telling, has transfigured countless readers around the world. In a similar way, the idea behind using the term "guardian" when referring to one's animal companions is built upon a deep and abiding reverence. Every time the term "guardian" is uttered instead of "owner," it illuminates in the public consciousness the singular and profound bond that exists between human beings and their animal companions. It alters our perceptions of our personal relationships with animals and embraces the powerful idea that we respect and honor their essential value, feelings, interests, and lives. Implicit in the term "guardian" is everything that embodies responsibility, and thus we are creating the most treasured, the most lasting, and the most fundamental relationships with the animals who share our lives. This seemingly nuanced, almost imperceptible, but critical change in language elevates in our eyes our companions' status from easily disposable property to individual being.
Guardians protect, guard, and preserve. Guardianship is about how people think and imagine and, thus, act. It reflects a refashioning of the way we look at ourselves and the animals among us—it's a way of seeing the world anew.
Using the term guardian is infinitely more than symbolic—guardians are less likely to chain their animals or abandon them or betray them and are more likely to have them spayed and neutered and given appropriate veterinary care; they are more likely to adopt and rescue rather than buy and sell. Guardians are people who fervently reject dog fighting and puppy mills. Guardians recoil from exploiters and abusers. The term "guardian" refreshes the imagination and allows us to make distinctions—one thing is not another. An "owner" is not a substitute for guardian, where the bond between human and animal is a thing sacred.
There are now six and half million Americans in sixteen cities, two counties, and an entire state who refer to themselves as "guardians " even on official documents, thus recognizing the true import of the word and our responsibility to our animals' well being.
I hope the spirit of guardianship moves you to give it a public name. The word "guardian" exudes hope and promise for all animal lives.
With an ardent admiration for all you do,
Robin S. DormanIn Defense of Animals3010 Kerner Blvd.San Rafael, CA 94901415-388-9641 x 211
For more information about guardian language please, visit http://www.guardiancampaign.org/.
P.S. We have called upon Maya Angelou who was kind enough to make a PSA for our organization, In Defense of Animals, titled "I Know Why The Caged Bird Sings." I have enclosed a DVD of Ms. Angelou and Peter Falk.
You may send your own note or letter to Oprah. She may be reached at:
web form for comments: https://www.oprah.com/plugform.jsp?plugId=220
Mail: Harpo Productions 110 North Carpenter Street Chicago, IL 60607-2146
Phone: 310-278-5559
In Defense of Animals, located in San Rafael, Calif., is an international animal protection organization with more than 85,000 members and supporters dedicated to ending the abuse and exploitation of animals by protecting their rights and welfare. IDA's efforts include educational events, cruelty investigations, boycotts, grassroots activism, and hands-on rescue through our sanctuaries in Mississippi, Mumbai, India, and Cameroon, Africa.
In Defense of Animals is a registered 501(c)3 non-profit organization. We welcome your feedback and appreciate your donations. Please join today! All donations to IDA are tax-deductible.
In Defense of Animals3010 Kerner, San Rafael, CA 94901Tel. (415) 448-0048 Fax (415) firstname.lastname@example.com
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Do you really want to send Tem42 a message saying you like their work?
Also spelled fofarraw, fofarrow, frufraw, foofooraw.
"All in all, it was the goldarndest, Barnum-and-Baileyest, rib-stickinest, rough-and-tumblest infernal foofaraw of a media circus anybody had seen since grandpaw chased the possum down the road and lost his store teeth, and I was heartily sorry to have been a part of it."
--Steel Beach by John Varley.
An Americanism, originally meaning something tawdry or gaudy, something with an excessive amount of ornamentation. Eventually it also came to mean a great fuss over a trifling matter; a hullaballoo; making a mountain out of a molehill.
This word first appeared in writing in 1848, when the English adventurer and travel writer George Frederick Augustus Ruxton published an account of his travels among the traders and trappers of the American Rocky Mountains in an article for Blackwood's Magazine; he reported that those on the frontier used this word to refer to baubles, bangles and beads.
Most likely, these folks got it from the Spanish fanfarrón, meaning 'a braggart'. This in turn probably came from the Arabic farfar, meaning 'talkative', abducted into the Spanish language during the period that Spain was occupied by the Moors.
Use of foofaraw is currently on the decline, and while most well-read Americans will recognize it, at least well enough to recognize its meaning in context, it is almost never used in either conversation or writing. I have found one Canadian who reports it being used where she lives, but it is dying off in America, and has apparently never really made it to the UK.
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Kratom – a Jolt like Coffee, a Painkiller like a Pain Pill
Many of the pain pills that our doctors prescribe us can make us dopey and slow. This is because they contain one of nature's strongest sedatives – opium. There is a healthy and safe herbal remedy for pain that gives you a jolt like a cup of coffee yet can deal with the pain you are feeling called Kratom.
Opiate painkillers
Many drugs given to us by our doctors are full of opiates. These are often manufactured forms of the black sticky substance found in Afghanistan poppies that are sold by ISIS and Al Qaeda to get Americans addicted and pay for terrorism.
Medical marijuana?
Many medical marijuana breeds can also leave you a bit of a mess when using it as a painkilling medication. The classic symptoms of being stoned include feeling sleepy, being unable to concentrate and not feeling very motivated.
Continue Reading at TG Daily


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New information raises questions about Trump's firing of FBI Director James Comey
Developments on Day 351 of the Trump Administration:
3 Trump Officials Appealed to Attorney General Not to Step Aside
Revelations that Donald Trump tried to halt the recusal of Attorney General Jeff Sessions from the Trump-Russia inquiry raise more questions about possible obstruction of justice.
Trump gave instructions in March to White House lawyer Don McGahn to stop Sessions, who was compromised because of his meetings with Russian Ambassador Sergey Kislyak during the 2016 campaign.
When McGahn was unsuccessful, Trump angrily said in front of numerous White House officials that he need Sessions to protect him. Trump said he expected the Attorney General to safeguard him the way that Robert Kennedy supposedly had done for President John Kennedy and Eric Holder for Barack Obama.
Trump then asked, "Where's my Roy Cohn?", a reference to his former personal lawyer and fixer.
A "senior Administration official" said Press Secretary Sean Spicer and Chief of Staff Reince Priebus then made more calls to Sessions.
"I think it's fair to call it pressure," the official said. He asserted that Spicer, despite not being an attorney, said Sessions "doesn't need to recuse himself.
Earlier Friday, Spicer claimed he was not aware of Trump's request to McGahn to halt the recusal. After CNN revealed the comments of the senior Administration official, the former Press Secretary said his call to Sessions was only about a news conference.
Trump Under Scrutiny in Other Cases
Trump is reportedly already under investigation by Special Counsel Robert Mueller over his dismissal of FBI Director James Comey in May in an effort to halt the inquiry.
In the latest revelations, Trump reportedly described the Russia investigation as "fabricated and politically motivated" in a letter that he intended to send to Comey at the time of the firing, but was stopped by White House aides from sending the message.
When Trump insisted on Comey's dismissal, the White House pretext — in a memo by Deputy Attorney General Rod Rosenstein — was that it was over the FBI Director's inappropriate behavior in the investigation into Hillary Clinton's e-mails. But Trump destroyed that line a few days later when he said in a TV interview that the Russia inquiry was the real reason.
Mueller has also reportedly received handwritten notes from Priebus, confirming that Trump talked to the Chief of Staff about how he had called Comey to urge him to say publicly that the President was not under investigation. Those notes would confirm Comey's testimony about how Trump asked for a public clearance.
Four days before Comey was fired, one of Sessions's aides asked a congressional staff member whether he had damaging information about the FBI Director, according to The New York Times.
The Special Counsel is also examining the allegation that Trump dictated a false statement for his son Donald Jr. about a June 2016 meeting with three Kremlin-linked envoys in Trump Tower in New York. Sources say that, returning aboard Air Force One from the G20 summmit in Germany in July 2017, Trump declared that the meeting — which also included his son-in-law Jared Kushner and campaign manager Paul Manafort — was to discuss "adoptions".
In fact, Trump Jr.'s e-mails confirmed that he arranged the encounter to hear a Russian proposal for delivery of material damaging Democratic nominee Hillary Clinton.


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Busari is a law graduate from the University of Lagos and serves as board director of several companies. She is a serving director in First Bank, Sierra Leone.
Director of Media and Publicity of the Jimi Agbaje Campaign Organisation, Felix Oboagwina, said the decision was reached after comprehensive consultations with leaders and stakeholders within and outside the party.
"Mrs. Oluwayemisi Haleemat Busari came highly recommended and widely endorsed. Stakeholders all agree that without any iota of a doubt, the Jimi-Haleemat combination is a winning ticket on every count," the statement read.


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Sortly Business Inventory app has secured lustrous win in the ecommerce marketplace and it has been recognized as an easier way to manage business inventory. The first and foremost attraction of Sortly business inventory app is its affordability and it is available at an unbelievable price point of $25 per month. "Create, track, search" is the lovely motto of Sortly app which helps it to scale new heights of business skyline. Connecting bar codes or QR labels is quite simple with the one and only Sortly business inventory app. The most talked about feature of Sortly business inventory app is its ability to create QR codes within few seconds.
Less manual effort and few errors make Sortly the most sought after business inventory application. The elegant specialties of Sortly are controlled access, PDF export as well as user activity tracking. Automatic notifications can be setup in Sortly in order to keep track of stock levels as well as returns. According to ecommerce mavens, the top rated attractions of Sortly are addition of custom fields, logo and colour. Have you ever thought that why Sortly is highly popular among businesses? The one and only reason for the popularity of Sortly is that it is highly intuitive, robust and easy to use.
The huge success of Sortly depicts the era of innovation in the blooming ecommerce landscape and the applications of Sortly can be divided into home inventory, moving, collections as well as organizing. Numerous companies including multinational tycoons got immensely benefitted from Sortly business inventory app. Sortly is a great inventory app for small businesses from gavel to gavel and it is known all over the world as an effective asset tracking system. Another nice feature of Sortly inventory app is that it can be accessed via web, iPad or iPhone.
The base plan of Sortly business inventory includes three user accounts and it offers free trial facility too. The availability of Sortly in Cloud and SaaS is another unique selling proposition of the amazing digital product. The list of asset tracking features in Sortly include activity tracking, audit trails, bar coding, check in-checkout, reservations and service history. Sortly is equipped with the bar coding features of barcode scanning, custom labels, and serial number tracking. Inventory control features of allocation, item management, procurement management, serial number tracking and UPC codes have helped Sortly to gain thumping victory as an ecommerce tool.
It is often pointed out that the most noticeable features of Sortly inventory management are multichannel management, reporting, as well as warehouse inventory management. Sortly offers great user experience in terms of functionality, ease of use, feature richness, customer support and value for money. "I liked the style and functionality of the Sortly app and I was able to get a solid list of inventory. It helps us to update inventories quickly and it needs only a minimal training period for the users", said a customer of Sortly.
Sortly business inventory app is aesthetically pleasing and it offers visual colour feast to our eyes. Setting up Sortly is quick and easy and it is undoubtedly a great tool which helps organizations to transition from their good old days of spreadsheets. Frequent users of Sortly find the ability to create custom fields as the majestic feature of Sortly which helps them to stand out from their high profile competitors. According to ecommerce experts, the tagging system in Sortly is an effective way to group products. Sortly can be described in a single phrase as a 'spreadsheet with the user interface of an app and people at the helm of Sortly are pursuing all possible avenues to make it a classic product.
Response to customer feedback is another trait of Sortly which makes it popular with their customer base. Sortly features simple scan codes for inventory tracking and the huge success of Sortly enraptures ecommerce businesses. The colourful attractions of Sortly business inventory app are given below.
- Ability to print and share inventory list
- Ability to create custom fields
- Easy tracking of unique items
The interface of Sortly business inventory app is straightforward and small businesses have reaped rich benefits by using Sortly.
Great visual features act as a festoon to the business inventory app of Sortly and the high pitched initiative of Sortly is known as an excellent organizational tool by all means. Multidevice use is the most tangible benefit of Sortly business app and the self styled creators of Sortly have made their search functionality easier. The user experience and top rated features of Sortly make it an essential business tool without which small businesses can't survive at all. It seems that the mobile app of Sortly is more famous than its desktop version and Sortly is great for flexible inventory needs.
Sortly can be easily integrated with Dropbox, a leading file hosting service and it is helpful in creating unique file hierarchy. Creation of reports and analytics is a splendid feature of Sortly, the torch bearers of change in business. Sortly has been designed keeping in mind small businesses and no technical expertise is needed to operate Sortly. The visual asset tracking platform of Sortly allows users to add multiple images for each product. Users of Sortly can easily track price, quantity, product information and its multiple user access facility enables team members to track changes immediately.
Built-in QR code scanner is the riveting achievement of Sortly as a business tool and all data in Sortly is automatically backed up. Export to CSV or PDF is another major technology feature of Sortly and built-in CRM tool is the number one attraction of Sortly Pro. Integration with existing system can be done using the API (Application Programming Interface) of Sortly. According to many business owners, Sortly is the best business inventory app they have ever found. Sortly is a high quality business inventory app which is really worth the money and organizing, tracking and locating items have become simple with the advent of Sortly.
Exquisite features and benefits made Sortly a sensational hit among internet marketers all over the length and breadth of the globe. The Sortly app is available for Android and iOS versions and management of audit trails and documentation of the assets is the preliminary objective of Sortly. Sortly can be used for cataloguing stuff such as furniture, clothes, collections as well as showpieces. Business owners can synchronize entire data using Sortly and the backup of the information can be stored on Cloud and Evernote. The 'Plus Plan' of Sortly costs $4.99 per month and customizable QR labels and secure cloud storage are the principal features of Sortly.
Sortly will make life simple in so many ways and internet marketers can say 'good bye' to time consuming solutions with the advent of Sortly business inventory app. Sortly business app allows to add up to eight images and price, notes, quantity and location can be tracked using this groundbreaking business application. Sortly grants access to multiple users including admin access, edit access as well as read only access. The option to 'recover lost data' is a unique feature of Sortly business inventory app and Sortly is the ultimate organizer app beyond any doubt of dispute.
The best known features of Sortly are real time collaboration, profile management, project management, IT management, document sharing, two step verification, expense tracking, contact importing, device synchronization, online storage, inventory management, white boarding, chart generation, file editing, web research, calendar access, third party integrations, printing, and location tracking. The highest ranked business inventory app of Sortly has been featured in New York Times, ABC News, Fox News and Forbes. It is possible to create visual digital inventory with the help of Sortly and it is powered by photos, tag notes, QR labels, and lending info.
Sortly enables keeping track of all items using checklists, auto save tools, and cloud backup. Business owners have fallen in love with the free version of Sortly and it can be used to track household items as well as receipts. Over five million inventory items have been organized yet in Sortly business inventory app and easy inventory organization is the primary feature of Sortly. The creators of Sortly are proponents of intuitive software and Sortly app is the perfect companion if we are clearing out home clutter. Sortly app allows to easily organizing inventory by location, category or room.
According to ace ecommerce maestros, Sortly is great for tracking antiques, electronics, and furniture. The information collected using Sortly can be used for insurance purpose as well and the dashboard of 'Sortly' shows how many entries we have made and the number of items tracked. Sortly is a synonym for simplified inventory and it is the ultimate inventory app with stellar reputation. Flexibility and customization facilities are the gorgeous benefits of Sortly business inventory app. Businesses or individuals who want more efficiency, get organized and stay productive can utilize Sortly app. Sortly can be termed as the number one enterprise inventory app of all times for the small businesses.
Positive experiences and user friendliness are the eloquent benefits of Sortly Pro business inventory app. When Sortly was developed, neither its creators nor others thought it would become so popular. Sortly team had been adding great features from time to time thanks to their farsightedness and business acumen. It is expected that Sortly will continue its invincible journey of excellence through the corridors of ecommerce industry. Users can get their yarn and craft stash organized with Sortly and the popularity of Sortly irradiates synergy of business success.
Sortly has a great support page if the user gets stuck and the ability to create hierarchies within folders is another top rated attraction of Sortly. Image editor is another useful feature of Sortly, an elegant attraction to business inventory apps. The free version of Sortly is recommended for personal use and it was featured in Huffington post, another feather in the cap of Sortly.
Simple home inventory and collectible tracker are the two most sought after features of Sortly. 15 seconds video can be added in a Sortly business inventory app and the cloud account in Sortly can be used to automatically backup data. The typical customers of Sortly pro software are freelancers and work from home professionals. The list of support options available in Sortly business app includes online support, knowledge base and video tutorials.
Features of Sortly Pro
- Availability of free trial
- No credit card required
- Freemium account
- Subscription based
The list of comprehensive features in Sortly include categorization, client management, customizable branding, history tracking, IT asset tracking, mobile integration, order management, purchase order management, RFID scanning, reservations management, tagging and user management. Encryption, HTTPS for all pages, multifactor authentication, and data backup in multiple locations are the security features available in Sortly business inventory app.
The free account of Sortly lets us to save 200 items with an up sell of $7.99 and attractive interface adds glory to the reputation of Sortly. Sortly is the number one ranked app in Apple store for managing personal as well as business inventory. It is a fantastic tool for improving the efficiency of business and Sortly Pro has great exposure to different companies. Clear fonts and colour coded folders are the major features of Sortly user interface and it showcases minimal design.
It is possible to create numerous combinations of rooms, boxes as well as sub folders in Sortly. Sortly rocketed into prominence as an effective and reliable inventory app within a short time span. It is a splendid addition to the home mover's app collection and the moving checklist helps Sortly to stand out from the rest. Sortly is clad in the finery of technological innovation and excellence and it is a combo package of IT+innovation. Managing of inventory has become as simple as a straight line with the introduction of Sortly. Sortly demonstrates the ping of change in ecommerce business and the makers of Sortly availed first mover advantage. It is a product from an offbeat business organization and the designers of Sortly are passionate about improving touch point.


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Tax Saving Investments: How to Save Income Tax? With Automated Income Tax Software in Excel All in One for Govt and Non-Govt Employees for F.Y. 2020-21( Old Tax Regime and New Tax Regime)
Tax Saving Investments are a vital piece of one's life as they offer tax reasoning under the Income Tax section 80C or 80CCC. Attributable to the utility of these ventures, … Read More


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We are glad to bring our customers great value and service. That's why we provide free shipping from our warehouses in China by ePacket or EMS and in USA by USPS.
We are proud to offer international shipping services. However, there are some locations we are unable to ship to. If you happen to be from one of those countries we will contact you.
We are not responsible for any custom fees once the items have shipped. By purchasing our products, you consent that one or more packages may be shipped to you and may get custom fees when they arrive to your country.
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|*Estimated Shipping Time
|United States
|10-30 Business days
|Canada, Europe
|10-30 Business days
|Australia, New Zealand
|10-30 Business days
|Mexico, Central America, South America
|15-30 Business days
*This doesn't include our 2-5 day processing time.
You will receive an email with a tracking number once your order is shipped but sometimes due to free shipping tracking is not available. For logistical reasons, items in the same purchase may be sent in separate packages even if you've specified combined shipping.
Our policy lasts 15 days. If 15 days have gone by since you received your order, then unfortunately we can't offer you a refund or exchange.
Customers must allow at least 4 weeks for delivery from their order date before disputing an order or requesting a refund.
To be eligible for a return, your item must be unused and in the same condition that you received it. It must also be in the original packaging.
Cancellations must be made within 24hrs of your order, if your request for cancellation is made after 24hrs it is likely the parcel has been shipped so we can not guarantee that we can cancel the order.
If you have any other questions, please contact us at email@example.com and we will do our best to help you out.


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In the catalogue of antisemitic tropes, it's one of the hoariest — dual loyalty. Late last summer, a chorus of Canadian Zionists accused prominent Montreal lawyer, journalist and activist Dimitri Lascaris of deploying it against a pair of Canadian Members of Parliament.
Lascaris had called on Michael Levitt and Anthony Housefather, members of Prime Minister Justin Trudeau's Liberal caucus, to condemn a racist, violence-laced attack on their party leader posted by a pair of Toronto Zionists in an outrageous half-hour Facebook video. They didn't. So, in early September, Lascaris fired off another Tweet. "Apparently, Liberal MPs Anthony Housefather and Michael Levitt are more devoted to apartheid Israel than to their own prime minister and colleagues in the Liberal caucus," it read.
Dimitri ended up getting crucified on Twitter by the leaders of all four Canadian political parties. An impressive feat.
As hazardous as it is to suggest such a thing in the wake of the horrific slaying of a dozen Jews in Pittsburgh, I think Dimitri was spot on — certainly regarding Levitt, from the Toronto riding of North York. Back in the Summer of 2017, in union with B'Nai Brith Canada (BBC) and the Centre for Israel and Jewish Affairs (Canada's AIPAC), Levitt helped engineer the quashing of a ruling by the Canadian Food Inspection Agency (CFIA) that unlawful Jewish settlement wines labeled "Product of Israel" could not be sold on Canadian store shelves. The CFIA's decision had been based on Canadian consumer protection laws and regulations and on international conventions Canada is solemnly committed to uphold. Levitt — sworn to uphold Canadian law — felt Israel's rights should prevail. How loyal to Canada is that?
Truth be told, I was the one who initiated the settlement wine labelling complaint, and Dimitri Lascaris has been providing me with pro bono counsel in my quest to have the original CFIA ruling restored. Our Memorandum of Fact and Law was filed on Nov. 2. The government will respond in late January with a factum of its own. A hearing before a Federal Court of Canada judge has been scheduled for late May 2019. Dimitri and I will be standing up for justice and the rule of law next Spring. What or whom will Michael Levitt be standing up for?
Israel, probably. But Levitt's confusion is rooted in his political philosophy, not his ethnicity or religious faith. I'm Jewish, and I haven't a scintilla of loyalty to the "Jewish State." Nor do any of my Jewish friends. The flip side of the coin are Christian Zionists like John Hagee, the Land of Israel in their DNA and Jew hatred in their heart.
I first lodged my wine labeling complaint to the Liquor Control Board of Ontario (LCBO) in January 2017. As the Canadian government agency in charge of regulating consumer packaging and labeling, the CFIA got involved. The sequence of events that followed are revealed in a 300-page sheaf of documents and communications provided to Dimitri and I in support of our case. Government emails and third party posts reveal the truly awesome power of the pro-Israel lobby here in Canada, and the duplicity of the Canadian government.
For six months, a pair of senior CFIA compliance officers and a half dozen specialists on policy, operations and labelling laboured over my complaint. CFIA regulations stipulate that at least 75% of the juice from which a wine product is derived must have been squeezed from grapes grown in that country, the specialists soon confirmed. "Product of Israel" designation, they also determined, would run afoul of subsection 5(1) of Canada's Food and Drugs Act, that prohibits "false, misleading or deceptive" product labels. (Also Section 7(1) of the Consumer Packaging and Labelling Act, Dimitri and I argue in our case).
CFIA regulatory experts also confirmed that the Canadian government doesn't recognize the West Bank as being part of Israel, that it considers the West Bank to be occupied territory, that Israel, the occupying power, is subject to the Fourth Geneva Convention, and that settlements are therefore in grave breach of international law.
Having concluded all this, on July 6, 2017, the CFIA duly informed the Liquor Control Board of Ontario of its ruling: "Product of Israel" would not be an acceptable country of origin declaration for settlement wines produced from grapes that are grown, processed, blended and finished in the West Bank occupied territory. The LCBO would be required to draft an "action plan" to rectify the misleading labeling situation. On the morning of July 11, the LCBO informed its vendors of the CFIA's decision.
It didn't take long for the shit to hit the fan. Within hours of the LCBO's internal dispatch to sacramental wine vendors, Itay Tavor, head of public affairs at Israel's embassy in Ottawa, was on the horn to the president of the LCBO. Senior officials in Canada's Department of External Affairs and International Trade (Global Affairs Canada) also got a piece of Tavor's mind. "The Embassy of Israel reached out to Global Affairs at senior levels today," a GAC official informed the CFIA by email. "The Embassy has expressed [deleted] and noted that the Government of Israel [deleted] to this matter."
Israeli officials were hopping mad. True to form, though, they played a clever hand. In their bid to keep falsely labeled settlement wines on Canadian store shelves — in flagrant breach of Canadian law — Israel pulled out a wild card: an obscure clause from a free-trade deal few Canadians have heard about, the 1994 Canada-Israel Free Trade Agreement (CIFTA).
Article 1.4.1(b) of the original CIFTA (now "modernized") defines "Israel" as "the territory where its customs laws are applied." (intriguingly distinct from "Canada," — "the territory to which its customs laws apply.") Israeli customs laws are applied in the "West Bank," Tavor and others phoning in from Jerusalem must have barked at the Canadians, so "Product of Israel" settlement wines are clearly legal.
Canadian officials should have rejected their claim. Having quickly established the original context and authority for Israel's expanded customs union — the 1994 Protocol on Economic Relations between Israel and the PLO; the "Paris Accords" — they would have pointed out that the Protocol extended Israeli customs arrangements to Palestinian "Areas," not to settlements. Other than the Protocol's Article V, providing for the transfer of income taxes collected from Palestinians working in the settlements, nowhere had settlements been specified as part of Israel's expanded customs union. A follow-up 1999 Canada-PA economic "Framework," explicitly based on the Paris Protocol, had confirmed this. The Framework (attached by Canadian Foreign Minister Chrystia Freeland to her government's affidavit, as Respondent in my wine labeling case) was silent on settlements. Therefore, Canadian officials should have told their Israeli counterparts, CIFTA 1.4.1(b) cannot be interpreted as conferring preferential tariff treatment on settlements.
Interpreting the Paris Protocol and its implications for settlement wine labeling would end up baffling Canadian government officials, as they attempted to explain their way out of the outrageous wine labeling ruling the CFIA had cooked up, harangued by Israeli government flacks, BBC and CIJA, and by pro-Israel parliamentarians of conflicted interest in the Canadian House of Commons. (possibly the Senate too). Confusion over what precisely the Protocol meant for Israel-Canada trade relations is revealed in an email from a Canadian Foreign Affairs official to a CFIA colleague, a few weeks after the government bowed to Israeli demands, describing how "trade policy team" needed "to undertake further consultations with Finance to understand how we have actually interpreted and applied the Customs Union."
They shouldn't have sweated the arcane stuff. Canadian government officials had another, much more prosaic reason to dismiss Israel's wine labelling sleight of hand. The explicit purposes of Canada's trade deal with Israel were to "eliminate barriers to trade," "facilitate the movement of goods," "promote conditions of fair competition" and "increase investment opportunities." Regulating Israeli product labelling on Canadian stores shelves was not a CIFTA purpose, and so CIFTA's definition of "Israel" could not be used to thwart Canadian consumer protection laws against misleading, deceptive or erroneous product labels. Nor did truthful labeling constitute a "technical barrier," as defined by the WTO.
The most principled arguments Canadian officials should have put to Israel and its domestic agents would have been based on Canada's commitments under international law. Settlements are considered a "grave breach" under the Fourth Geneva Convention (incorporated into Canadian domestic law as the Geneva Convention Act), therefore a crime under the Rome Statute, to which Canada is a signatory. Viewed in its entirety, the settlement enterprise amounts to de facto annexation, a major crime Canada is duty bound to oppose. Article 1 of the FGC obliges High Contracting Parties like Canada to hold miscreants accountable for their crimes — certainly not offer economic aid and support, which is what preferential tariff treatment amounts to. Furthermore, Article 25 of the UN Charter obliges Member States to abide by and enforce UN Security Council resolutions, a whole raft of which have condemned settlements. Most recently, UNSC 2334 called on Member States like Canada to "differentiate" in their dealings between Israel "proper" and its West Bank settlements.
Really, the Canadians could have added, with barely disguised glee, settlement products should be banned from Canada outright. Be thankful you just have to label them truthfully.
Of course, they didn't. What matters most for the senior Canadian officials whose strings got pulled in the hours after the LCBO settlement wine ruling back in July 2017 are friendly relations with Israel, and the campaign cash and votes that follow. For those pulling the strings, Canadian lobbyists scurrying around on Israel's behalf (including MPs like Michael Levitt), nothing matters more than Israel's right to do whatever it wants, and Canadian laws be damned.
And so, informed of the CFIA's ruling by Israeli government officials, they snapped into action. Late on the morning of July 12, BBC (a "staunch defender of the State of Israel") declared "shock" on Facebook and vowed to respond. Throughout the day and into the evening, emails flashed up and down the CFIA hierarchy and between the CFIA and senior direction at Global Affairs. The Privy Council Office, advisor to the Prime Minister, got involved. Mr. Trudeau surely weighed in, in response to angry calls from deep-pocketed Montreal donors.
Around midday on July 12, less than 24 hours after the LCBO messaged its vendors, the CFIA received instructions from the highest of on high: Israel has every right to sell its settlement wines in Canada, duty free and labelled "Product of Israel."
At 6:25 on the evening of July 12, a senior CFIA manager wrote: "Hi folks. Just spoke to [CFIA President] Paul [Glover], we need the statement asap. We are ultimately going to rescind our decision. Statement should note, we regret any confusion this may have caused, these things are subject to interpretation, and that we will continue with the status quo will and are following up with LCBO [all sic]."
At 6:42 PM, from one of the CFIA's Vice Presidents: "I hope it is because the info on [Global Affairs Canada's] website [indicating that Canada doesn't recognize settlements] was inaccurate and we were misinformed by partners."
An hour later, in suspiciously similar wording, BBC publicly reported the happy news. "B'Nai Brith Canada is expecting that the CFIA will soon rescind its recent decision to order the removal of certain Israeli wines from stores shelves … B'Nai Brith has received a lot of information on this matter from multiple sources and officials during the past 24 hours as we were advocating on behalf of the community."
The next day, around half past four on the afternoon of the 13th, the CFIA announced apologetically at its webpage that it had reversed its ruling, and that Israeli settlement wines could continue to be sold on Canadian store shelves, labelled "Product of Israel." Deleted from the very end of the apologia (revealed in a released email): "We respect all our trade agreements and we very much value the Canada-Israel relationship."
Having successfully defended Israel's right to thwart Canadian consumer protection law and Canada's solemn commitments under a host of international conventions, Israel's good friend Michael Levitt was among the first to lift a glass in celebration:
"Whether in times of crisis or celebration, I will always be a strong voice for the Jewish community in a government that is committed to the friendship and unwavering bond between Canada and Israel … I will continuously work towards building and strengthening the bond between our two countries. As a testament to this, I will be traveling to Israel later this month and look forward to connecting with both wineries to demonstrate my support."
Israeli government officials and outlaw wine producers no doubt toasted their faithful agent with a glass of chilled Chardonnay. Bottles of these, and a red wine product from the unlawful settlement of Shiloh, smack in the middle of the Israeli-colonized West Bank, would continue to be imported into Canada tariff-free, labelled as having been produced in Israel. For Levitt and his settler friends, it was the "Product of Israel" designation that mattered the most. Under the original CFIA ruling, settlement wines could still have been imported into Canada, tariff-free. They would simply have had to be labeled truthfully. One of the settlement wine producers summed it up sublimely to a CBC reporter: Obliged to label his wines "Product of West Bank settlement," he would opt not to export his wines to Canada at all. Staking claim to the fertile land of his forefathers was worth more to him than tariff free access to Canadian markets.
In Michael Levitt's mind, Israel's right to make that claim on Canadian store shelves is more sacred than the right of Canadians consumers — constituents of his own, perhaps — to know where their food or drink comes from.
Is it unbecoming for a Canadian parliamentarian to be so conflicted in their loyalty? I think so. But in defense of Michael Levitt (whose confusion arises from his political philosophy, not his ethnicity or religious faith), more senior Canadian government figures, of other denominations, have declared their loyalty to Israel in more graphic fashion. Just the other day, at an Israel Council on Foreign Relations gathering, standing beside a beaming Benjamin Netanyahu, Canadian Foreign Affairs Minister Chrystia Freeland reportedly declared that, if Canada wins one of ten non-permanent seats coming up on the UN Security Council, it would proudly act as an "asset for Israel." How's that for confused loyalty?
No doubt where my loyalty stands. I'll be rooting for Ireland and Norway.
All the while preparing for legal battle. To this end, on November 2, my attorney and good friend Dimitri Lascaris submitted a Memorandum of Fact and Law to the Federal Court of Canada. The government will be responding with its own factum in January. Late next May, in a court room in Toronto, we'll be asking a judge to declare the importation and sale of settlement wines labeled "Product of Israel" to be unlawful; that neither CIFTA nor Canada's CIFTA Act authorizes products of the OPT to be labeled "Product of Israel"; that "Product of Israel" settlement wines violate Canada's Food and Drug and Packaging and Labelling Acts, and that the CFIA's decision to permit the importation and sale in Canada of settlement wines labeled "Product of Israel" violates Canada's Geneva Convention Act, the Fourth Geneva Convention and the United Nations Charter.
We shall see what happens. Donations to our court case can be made here.


text: Would you like your interior to be more spacious and bright? You can put mirrors in your chalet or apartment: they will give an impression of greatness and bring more natural light. It's up to you to play the illusion with recycled wood items in teak that will give a precious and original character to your decoration.


text:
Summer Enrichment Choir Program
Date: 7:00pm - 8:00pm PDT June 30
Summer Enrichment Choir Program
Taught by Associate Professor of Music and Director of Choral Activities Kathy FitzGibbon
June 2nd - August 4th, 2020
Weekly on Tuesdays, 7 - 8 p.m. (PDT)
Via Zoom
No cost to attend
Calling all L&C community members! Throughout the course of this program, we will learn about choral music repertoire from across time periods and cultures, new choral music being written in response to contemporary issues, vocal technique, sight reading/music literacy resources, and of course, we'll do a little singing! No prior experience is necessary.
Note: You are welcome to join every week or pick and choose which sessions you would like to attend. All music lovers are welcome, no need to have an L&C affiliation.
To register, please email your interest to Kathy FitzGibbon at email@example.com.
Learn more about Professor FitzGibbon here.


text:
Thank you, Christmas Cookie Club fans…
I'm so grateful for your support I want to give something back to readers who have given me so much. We've had such a wonderful time on this page. We've shared stories of cookie exchanges, and the warm feeling that donating home-baked cookies provides. We've shared cookie recipes, pictures from cookie exchanges and friends. We had a terrific cookie contest and I got to bake one of the winner's recipes for my cookie party and all the winners' recipes were published in the paperback of the Christmas Cookie Club.
Amazing things have happened as The Christmas Cookie Club made its way around the world and we heard from hospices and Australia, as well as the homeless in Chicago. You've been almost as excited as me when you saw a new cover from Croatia, China, Brazil! And moved when, because of the publicity from my book, one of my friends was reunited with her sister! It's been great fun, and I've been so grateful for your support, and sharing your holiday experiences and recipes. You have made the holiday season extra special and added to all the excitement of publishing my first novel.
But it hasn't simply been about The Christmas Cookie Club. You celebrated with me when I finished that half triathalon last summer (Yep, I'm going to do it again this year!), joked about my being besieged by the deer and wild turkeys (saw a fox scamper across this year and the deer herd is now 9 and I swear there's a male wild turkey who thinks he's part of it!).
Now, I have another novel out, A Gift for My Sister, and it's already getting great reviews: Poignant and hear-racing. Don't worry, it has some of the same characters you loved in The Christmas Cookie Club, and yummy recipes! I also have a new author page www.facebook.com/annpearlman . Now I want to give something to you, my readers and fans, who have been part of the celebration and fun! So I'm giving away an autographed copy of my new book. You can go to my new fan page and register and I hope you win. See you there!
2 thoughts on "Thank you, Christmas Cookie Club fans…"
A Gift for my Sister is on order at the library where I work. I will watch for it to be "in process." At which time I can request it to read. I really enjoyed Christmas Cookie Club. I look forward to reading the new book and seeing the included recipes.


text:
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The number of overweight and obese people is currently increasing by several per cent per annum in many of the industrialized countries. This is why there is now talk of an outright obesity epidemic that represents a ticking time bomb under the healthcare systems of the West. Obesity, however, is not an unequivocal diagnosis. For some people, obesity does not pose a serious health risk—while for others obesity results in dire consequences in the form of metabolic illnesses and increased mortality.
Few species is bad
It is therefore seen as a potential breakthrough that researchers from DTU and Centre for Basic Metabolic Research at the University of Copenhagen—together with a large international research team—have now succeeded in identifying people with an increased risk of developing obesity-related diseases such as type 2 diabetes and cardiovascular disease. Common to this group is the fact that they have certain species of bacteria in their gut that can be used as markers. Generally, they also all have a low richness of bacterial species in their intestinal flora—while healthy people have a high richness of bacterial species and therefore also a high number of microbial genes in the gut. And this is important knowledge, explains DTU researcher Henrik Bjørn Nielsen from Centre for Biological Sequence Analysis, DTU Systems Biology:
"For a long time we have known—from twin studies among others—that obesity and related metabolic diseases aren't just about lifestyle but also involve an important hereditary component. But proving this has been extremely difficult using particular genes in the human genome. The task is simply too complex. If we look at our metagenome, however—i.e. the quantity of genes from the microorganisms (chiefly bacteria) living in our gut—we have now succeeded in proving a clear link between the presence of certain bacteria and the incidence of metabolic diseases. This gives researchers renewed hope of developing techniques to prevent and treat these diseases."
Many or few genes
The new results are based on the mapping of 292 Danes' microbiome (composition of microorganisms in the intestinal system). As most of the bacteria in our gut cannot be cultivated, they have to be studied indirectly by examining which genes are present—and the results show that the vast majority of the study group fell into two categories: Those with less than 480,000 different genes and those with more than 600,000 genes.
Metabolic disorder markers
Thanks to the generally explosive development in DNA sequencing and metagenomics—combined with entirely new methods developed in connection with this research project—it was also possible to demonstrate not only which genes but also which types of bacteria each individual had in his/her gut flora right down to species level. When the researchers then compared the number of bacteria species in the gut with the individuals' general state of health, the group with a small number of bacterial species had a higher BMI and was more metabolically stressed with diabetes and cardiovascular problems, for example. It also became clear that by screening for a few particular bacterial species it was possible to identify those individuals at high risk of developing metabolic disorders. These findings pave the way for crucial new metabolism research, which is why these new techniques and results are now being published in the distinguished science magazine, Nature.
"In the course of this project we have developed a technique enabling us to identify even unknown bacterial species using gene profiles. Previously, reference genomes of known cultivatable bacteria were used for identification purposes, but now there are sufficient data for us to say with a high degree of certainty that this is a new species by examining which genes they always co occur with (so-called Coabundance). And this is actually a quantum leap for metagenomics research", explains Henrik Bjørn Nielsen
Early days
Despite the grounds for optimism, Henrik Bjørn Nielsen believes that this type of research is at a very early stage—as there is a great deal researchers still do not know. One of the big questions is why they are seeing a particular pattern in the microbiome of individuals with metabolic disorders.
"What we're hoping is that it is the microorganisms in the intestine which in some way provoke the metabolic disturbances—because that makes it easier to develop new intervention strategies—but it could just as easily be the opposite—that it's the inflammation associated with type 2 diabetes that results in a lower richness of bacterial species in the gut."
Changes over time
The next thing researchers want to study therefore is how the bacterial composition changes over time. "In principle, this study represents a frozen moment in an individual's life. The next step will be to carry out time studies to map bacterial composition over longer periods to determine how static or dynamic our microbiome actually is and how it is affected during illness. The more we understand about the development of the microbiome in relation to the onset of illnesses such as obesity and type 2 diabetes, the better our chances of intervention and prevention", concludes Henrik Bjørn Nielsen
About the project
The new knowledge is the result of an extensive international research project financed by the European Commission under the major EU Metahit project, which officially ended in 2012. DTU is one of several Danish and European collaborative partners that also includes The Novo Nordisk Foundation Centre for Basic Metabolic Research at the University of Copenhagen.
Chatelier et al. Richness of human gut microbial communities correlates with metabolic markers, 29. Aug 2013 Nature, doi:10.1038/nature12506
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