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Decision day: Huge vote expected / FINAL BLITZ: Bush, Kerry race across the nation at close of tight contest
President Bush and Sen. John Kerry stormed across the United States on Monday in search of the elusive handful of votes that could tip a hard- fought, deeply partisan presidential race expected to bring a record number of Americans to the polls today.
California, Ohio and Florida are among the states anticipating the highest turnouts in a generation, and some analysts say more Americans may vote today than have ever voted in a presidential election. The flood of voters, many of them newly registered, could lead to problems at the polls, which could translate to a late, and possibly contested, result.
"We need a clear-cut outcome," said Paul Maslin, a Democratic pollster. "If we end up fighting in multiple states, can anyone imagine the type of damage that will do?"
Both sides are ready with platoons of lawyers should any state produce the kind of problems that marred Florida's election results in 2000.
"I expect this election is going to be decided Tuesday night," Kerry told the Associated Press Sunday, "but, given experience, I would be irresponsible if I wasn't prepared to be able to protect every person's right to vote."
The presidential election is so tight that the campaigning won't end until well into election day. After a huge rally in Cleveland on Monday night, Kerry spent the night in La Crosse, Wis., where he was slated to appear this morning at a get-out-the-vote rally with Democratic Gov. Jim Doyle before heading home to Boston. The president planned to vote this morning at a firehouse near his ranch in Crawford, Texas, and scheduled a final stop in Columbus, Ohio, on his way to Washington, D.C.
Early Monday afternoon, the two candidates made back-to-back visits only three blocks apart in Milwaukee, signaling the importance of Wisconsin -- one of 10 battleground states that analysts still consider tossups.
The prospect of another razor-thin decision comes after four eventful years that included the Sept. 11, 2001, terrorist attacks, wars in Iraq and Afghanistan, tax cuts, record deficits and a roller-coaster ride of polls that took the Republican president's popularity up to record heights and down to unexpected lows.
"A lot has changed since the 2000 election, but it's brought us back full circle," said Michael Genovese, a political science professor at Loyola Marymount University in Los Angeles. "It's absolutely incredible that after 9/11 and a winning war in Iraq, Bush's popularity could have crumbled so quickly."
The war in Iraq gets either the credit or the blame, and Bush's appearance in a flight suit on the deck of the aircraft carrier Abraham Lincoln under a "Mission Accomplished" banner marked the turning point.
"The war in Iraq stiffened the opposition to Bush," Maslin said. "From a political standpoint, if we hadn't gone to war, Bush likely would have been re- elected handily."
But a seemingly endless stream of bad news from Iraq, from the economy and from the findings of the Sept. 11 commission hasn't done more than push the election into a statistical tie.
For many voters, the focus has changed from concern about the economy and major news events such as the war in Iraq to worries about such social issues as abortion and stem-cell research.
"Increasingly, the electorate is divided by fundamental cultural issues, " said Matthew Wilson, a political science professor at Southern Methodist University in Dallas. "These are bedrock issues that drive the vote. Someone who's anti-abortion before Sept. 11 is still going to be anti-abortion after Sept. 11."
The result is a country that's still polarized, but along very different lines that are increasingly hard to cross. It's a division that won't be changed by the typical ebb and flow of a political campaign.
"Each candidate has a base of 42 or 43 percent that sees everything in a positive light and will explain away any bad news," said Bruce Cain, a political science professor at UC Berkeley.
Many Democrats continue to explain away Bush's entire presidency on his disputed 537-vote victory in Florida over Democrat Al Gore, which took 36 days and a U.S. Supreme Court decision to determine. Those Democrats have never accepted the legitimacy of Bush's victory after he became the first president since Benjamin Harrison in 1888 to lose the popular vote but win the Electoral College.
Another tight election is likely to bring more bad blood, recriminations and calls for political vengeance.
"If Bush wins, he is going to be reviled by the left for another four years, and if Kerry wins, it is going to be the same thing on the right," said Stephen Moore, president of the conservative Club for Growth, which has run television ads attacking Kerry during the campaign.
Whoever wins the election must deal with that bitterness.
"The first job of the new president must be to find common ground so the country can move ahead," Genovese said. "That's likely to be even harder than fighting the war on terror."
An upbeat Bush pushed through a six-state, 19-hour campaign schedule Monday, saying he was energized by his supporters and confident he would win.
"It's like that marathon stretch -- the finish line is in sight," Bush told reporters at a military airfield west of Pittsburgh. "I just want to assure you that I have the energy and the optimism and the enthusiasm to cross the line."
Bush, who got up at 5:30 a.m., arrived at his first event in Ohio aboard Marine One, the presidential helicopter -- his landing framed by the enormous doors of an airplane hangar.
"There is nothing like an early-morning rally in the great state of Ohio! " Bush exclaimed in Wilmington, at 7:25 a.m. on his sixth straight day in the state.
The New England airwaves, which reach the crucial battleground state of New Hampshire, were jammed Monday with an avalanche of last-minute ads, many from independent groups like MoveOn.org, which urged voters to support Kerry.
In a final four-state, six-city blitz Monday, Kerry appeared relaxed, telling an airport audience in Florida that today's vote is "a moment of accountability for America ... the world is watching what you're going to do, " he said. "All of the hopes and dreams of our country are on the line today. "
And in Milwaukee, the Massachusetts senator, who has taken to wearing a Boston Red Sox cap -- the trademark of his hometown World Series champion team -- exhorted voters, saying "I need you, in these hours, to go out and do the hard work ... help us change the direction of this great nation."
Party leaders on both sides were less concerned about their candidates Monday than they were about the people who will vote for them. Get-out-the- vote efforts were in full swing.
In Ohio, election officials are bracing for a massive turnout today. Ohio Secretary of State Kenneth Blackwell, a Republican, has predicted that 73 percent of registered voters will show up at the polls.
The state has added 1 million new voters to its rolls since 2000, and the latest data released by county election boards suggest that a strong majority of new voters were added in Democratic zip codes that backed Gore in the 2000 election.
"If you have 1 million new registered voters and a forecast of a high turnout, it's hard to see how that doesn't end up helping the Democrats," said Herb Asher, a political science professor at Ohio State University.
Curtis Gans, director of the nonpartisan Committee for the Study of the American Electorate, estimated that as many as 121 million Americans would cast votes, 58 to 60 percent of those eligible. Those are percentages that haven't been seen since the 1960s.
When it comes to turnout, the more the better, say Democrats, who know that Kerry can't win without carrying at least one state Bush claimed in 2000. Democrats are hoping that get-out-the-vote operations financed by organized labor and other organizations will help them hold Pennsylvania, where Gore won in 2000, and take Ohio, which Bush won as part of a 271-266 Electoral College victory.
Republicans counted on their own nationwide effort to mobilize, particularly in small towns and distant suburbs where they hope the president's opposition to same-sex marriage, abortion and gun control give him an opening with conservative Democrats.
Pollsters also warned that there's not a survey in the world that can accurately predict the winner in a state where the election swings on a few hundred votes, as happened in Florida and New Mexico four years ago.
Barbara O'Connor, professor of political communications at Sacramento State University, said the election of 2004 may be remembered as one in which the role of young voters was pivotal, since many of them support Kerry.
"The X factor is totally the turnout of young voters," she said. "And I think they will turn out, in which case we will probably know (Wednesday morning) who has been elected."


text: As more and more big companies enter the streaming scene, content becomes more expensive to acquire – and original programming becomes more and more important. Netflix has had some huge hits with its original series, and HBO has been in the original series game for longer than it's been a streaming company, but Amazon isn't far behind its big streaming rivals. Amazon's original series have won awards and drawn new users to Amazon Prime (you can read our review of Prime here), and they're more than worth checking out if you haven't already. You can dive in with any of Prime's originals, but if you want a surefire winner, choose one of our picks for the best Amazon original series. Bosch There are some familiar elements in Bosch, including the title character (a gritty cop who does things his own way!), but the show works well. Some great actors from HBO's The Wire found their way into this show, which is exciting and fun even if it's not exactly groundbreaking. This is a great show for passing the time and enjoying some action. Titus Welliver stars as the title character, a cop in (where else?) Los Angeles. The Man in the High Castle The Man in the High Castle is a miniseries adaptation of the Philip K. Dick book of the same name. It's an alternate-history thriller set in a world where the Allies lost World War II. Axis powers occupy the United States, with the Nazis holding the East Coast and Midwest and the Japanese holding the West Coast. All of this becomes the backdrop for a complex story of resistance fighters, government officials, and double agents. If you're looking for action, this is Amazon's best offering. Mozart in the Jungle Mozart in the Jungle pulls the stage curtain back on the world of elite classical musicians. It's a surprisingly fascinating show that mixes drama and comedy as it tells a modern-day story about classical musicians who aren't quite as stuffy as you might expect. Sex and drugs abound, but they're not a crutch. The show has real drama to back up the steamy stuff, and the series gets stronger as it goes on. Red Oaks Red Oaks doesn't get the press that some of these other originals have earned, but it really holds its own among Amazon originals. It's a throwback comedy set at a country club in the 80s (if that reminds you of Caddyshack, you're not alone – though tennis, not golf, is the focus of this one). Red Oaks is witty and well-acted, and it's more than worth your time if you're a fan of 80s comedies. Transparent Amazon's groundbreaking comedy about a transgender father and his selfish adult children isn't just one of the best Amazon original series – it's one of the best original series from any of the streaming giants. It's also the most decorated Amazon show, having won two Golden Globes and a handful of Emmys. Transparent is brilliant and important, but it's also simply funny – it's by far the best comedy Amazon has come up with. If you're only going to watch one Amazon original, make it this one.

subset: commoncrawl


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5 Tips To Use When Planning Your Next Vacation!
For many of us, summer means one thing – time to jet set to the next tropical location on our bucket list! There are many steps to planning the perfect vacation – planning travel, packing the family, dogsitters, TSA approved product – the list goes on and on.
When you're planning your summer vacation or weekend-getaway, make sure you are doing these 5 tips to guarantee a successful traveling experience! Read More


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Daily Mission Guide
This post is a quick guide showing you how to complete the daily mission: Attack enemies using portable toilets, which can be found in Breezy Hills
The first thing you want to do is get to the map Breezy Hills, which is located right here on the world map, under the Victoria Island tab.
You can either get there directly with the air taxi or simply go to Kerning City and walk from there.
When you reach the map Breezy Hills, you have to locate portable toilets which look like this.
Simply walk up to it, press your action key to pick up the portable toilet (default key is space) and then press your action key again to attack with it. Do this 5 times and you will have completed the mission.
Below is a short video showing you how to clear the mission


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[Frontiers in Bioscience 5, e103-109, November 1, 2000]
Fady Chamoun, Melissa Burne, Michael O'Donnell and Hamid Rabb
Division of Nephrology, Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN 55415
Research findings are unveiling the potential role of leukocytes and leukocyte adhesion molecules such as selectins in ischemia-reperfusion injury (IRI). "Anti-adhesion" therapy using selectin blocking agents may represent a new approach to treatment of the many diverse clinical disorders in which ischemia-reperfusion occurs, including transplantation, reperfusion after thrombotic events and shock. In this paper we review the pathophysiology of IRI, the different types of selectins and selectin ligands, the clinical implications of selectin blockade in different organs with IRI, and new insights into mechanism of action.
Recent developments in immunology and cell biology have demonstrated the importance of inflammation in the pathogenesis of post-ischemic organ dysfunction. Whereas prolonged ischemia causes anoxic cell death, recent evidence suggests that sublethal injury may be amplified by inflammatory and cytotoxic injury cascades activated during the reperfusion period.
Ischemia is a state of tissue oxygen deprivation accompanied by a reduced washout of the resulting metabolites (1). Reperfusion is the restoration of blood flow to the ischemic tissue. Despite the unequivocal benefit of reperfusion of blood to an ischemic tissue, reperfusion itself can elicit a cascade of adverse reactions that paradoxically injure tissue (2). Indeed, reperfusion injury has been well described in the literature to cause organ damage in the brain, heart, lungs, liver, kidneys and skeletal muscle. The susceptibility of tissue to ischemia reperfusion injury (IRI) is a major obstacle to both reperfusion after an infarct and successful organ transplantation.
The incidence and implications of ischemic injury are enormous: ischemia occurs in myocardial infarction, stroke, organ procurement injury, and many other situations. In 1995, ischemic cardiovascular events alone were the diagnosis in 5 million (16.2%) hospital patient discharge records and were the leading cause of death in the United States (38.7%) (3).
A growing body of evidence, primarily from animal models of IRI and preliminary human studies has revealed that inflammatory mechanisms play a major role in the pathogenesis of IRI. Interest in the inflammatory response to IRI has led to the identification of multiple inflammatory mediators, including leukocytes, leukocyte adhesion molecules and cytokines.
In the following review we will focus on the pathophysiology of ischemia-reperfusion, the role of leukocytes in the post-ischemic inflammatory cascade, and the crucial role of the selectin family and their ligands in mediating leukocyte induced post-ischemic injury.
The pathophysiology of the IRI is complex. The inflammatory aspect of IRI includes both the cellular and humoral components (Figure 1). Moreover, mechanisms of IRI may be organ-dependent, with similar but distinct pathways involved in different organs. During the last decade there has been an explosion of research documenting the role of leukocytes and leukocyte adhesion molecules in IRI (4). Multiple mechanisms have been postulated for the leukocyte-mediated tissue injury that occurs after ischemia-reperfusion. Microvascular occlusion (5), release of oxygen free radical (6), cytotoxic enzyme release (7), increased vascular permeability (8) and increased cytokine release (9) have all been demonstrated to contribute to leukocyte-induced tissue injury.
Figure 1. Proposed inflammatory cascade in ischemia-reperfusion injury.
Leukocyte adhesion molecules (LAMs) are expressed on leukocytes and other cell types and regulate many leukocyte functions. LAMs function in various biological processes such as development, signaling, inflammation and apoptosis. There currently exists a multi-step paradigm of leukocyte emigration to inflamed tissue that involves specific leukocyte adhesion molecules (Figure 2). To emigrate into tissue, leukocytes initially tether to and roll on the vascular endothelium. This relatively loose adhesion is mediated by the selectin family of adhesion molecules and their ligands (10-12). Subsequent activation of leukocytes and the endothelium leads to firmer adhesion mediated through integrin adhesion molecules (e.g., CD18) and their receptors (e.g., intercellular adhesion molecule-1, ICAM-1). Leukocyte transmigration is the final stage and occurs between endothelial cells. Leukocytes then travel through the extracellular matrix to the source of tissue injury, guided by a concentration gradient of cytokines and chemokines produced at the site of injury.
Figure 2. Current model of leukocyte migration to inflammed tissue.
Because selectin engagement of leukocytes precedes CD11/CD18 binding to ICAM-1, targeting selectins is an attractive way to block inflammation at an even earlier step. In addition, selectin blockade might cause less susceptibility to bacterial infections than does CD11/CD18 blockade (13).
The selectin family of leukocyte adhesion molecules consists of three known members: L-, P-, and E-selectin (table 1). These molecules are involved in the initial adhesion of leukocytes to activated endothelium at a site of tissue injury (14-19). L-selectin is a cell surface glycoprotein expressed constitutively on a wide variety of leukocytes (15). L-selectin plays a role in the emigration of lymphocytes into peripheral lymph nodes and sites of chronic inflammation and of neutrophils into acute inflammatory sites. P-selectin is a cell surface glycoprotein that also plays a critical role in the emigration of leukocytes into tissues (17). P-selectin is constitutively stored in the Weibel-Palade bodies of endothelial cells and in the alpha granules of platelets. It is expressed on the cell surface within minutes after exposure to stimuli such as thrombin. E-selectin expression is largely restricted to endothelial cells activated by different stimuli such as endotoxin and the pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF) (19). E-selectin expression peaks within 4-8 hours of tissue injury and returns to baseline by 24 hours (16). E-selectin expression, as with P-selectins, requires de novo messenger RNA and protein synthesis, and involves the translocation of the transcription factor NF-kappaB onto nuclear promoter sites (20).
Table 1. Structure and expression of selectins
PSGL-1 = platelet selectin glycoprotein ligand; ESGL-1 = endothelial selectin glycoprotein ligand; L= lectin; E= Epidermal growth factor-like molecule; C= Complement-binding protein-like.
In the first 10-20 minutes after tissue injury, leukocyte rolling on the vascular endothelium is mainly mediated by P-selectin, with minimal L-selectin contribution (14). This is consistent with the rapid mobilization of P-selectin from intracellular stores after tissue injury. After approximately 20 minutes, the role of P-selectin diminishes secondary to internal degradation, and L-selectin becomes the principal mediator of leukocyte rolling. There is little appreciable role for E-selectin in leukocyte rolling during the early response (<2 hrs) to tissue injury. While E-selectin expression on stimulated endothelial surfaces is detectable at 2 hrs after injury, the delay in peak surface expression precludes the contribution of E-selectin to the early rolling and leukocyte recruitment in acute inflammation. Rather, initial interactions between leukocytes and the vascular endothelium, mediated via P- and L-selectins, are followed by a stronger interactions, probably involving E-selectin and subsequently integrins, that lead eventually to extravasation through the blood vessel wall into lymphoid tissues and to sites of inflammation (16).
3.2. Selectin ligands
While initial studies suggested that all three selectins recognize carbohydratescontaining the sialyl Lewis x antigen (NeuAca2®3Galß1®4[Fuca1®3] GlcNAcß1®R) (sialy vl Lex), however, recent studies have now shown that each selectin demonstrates higher affinity binding to specific macromolecular ligands expressing sialylated and fucosylated glycans. To date the best characterized cell adhesion ligand for selectins is the P-selectin glycoprotein ligand-1 (PSGL-1). Although PSGL-1 is expressed on the membrane surfaces of all leukocytes, with respect to binding of P-selectin, it is only functional on granulocytes and subclasses of lymphocytes. Interestingly, PSGL-1 may also serve as a ligand for both E- and L-selectin (21).
Treatment of purified PSGL-1 with sialidase abolishes its binding to P-selectin, confirming cell studies that indicate a role for sialic acid in P-selectin recognition (22,23). Interestingly, treatment of neutrophil-derived PSGL-1 with peptide N-glycosidase F, which removes most of the N-glycans of the molecule, does not affect its recognition by P-selectin, suggesting that O-glycans, but not N-glycans, are important determinants of selectin binding (22). PSGL-1 may also be an important signaling molecule in neutrophils. Upon activation of polymorphonuclear leukocytes there is a redistribution of PSGL-1 resulting in a lowering of affinity of activated cells for P-selectin (23). Incubation of neutrophils with either P-selectin or the monoclonal antibody PL1 to PSGL-1 stimulates tyrosine phosphorylation of several proteins and production of IL-8 (24).
In vivo approaches to studying the importance of glycans in selectin ligand function have recently provided exciting new insights and have partly confirmed predictions about the importance of sialyl Lex and core-2 O-glycans for PSGL-1 recognition by P-selectin. Neutrophils from null mice lacking the myeloid enzyme fucosyltransferase VII bind poorly to P-, E- or L-selectin, and neutrophil efflux in experimentally induced inflammation in such mice is dramatically reduced (25). Another approach to studying PSGL-1 function during in vivo inflammation has been to explore its role in ischemia/reperfusion injury models, in which blood flow is blocked and subsequently restored, thereby stimulating P-selectin expression by endothelial cells. In a rat model of hepatic ischemia/reperfusion injury (26), animals treated with 100 �g of recombinant PSGL-1 had significantly enhanced recovery of liver function and higher survival. PSGL-1 may also be important for lymphocyte recruitment to sites of inflammation in vivo, since intravenous administration of antibodies to the extreme N-terminus of mouse PSGL-1 blocks migration of Th1 T-lymphocytes into skin undergoing cutaneous delayed-type hypersensitivity reactions (27).
While all three selectins can bind to simple glycans containing the sialyl Lex determinant, as demonstrated for P-selectin and PSGL-1, such binding is
relatively weak and macromolecular ligands bind with higher affinity. Although several glycoproteins are recognized by L- and E-selectin, whether these ligands serve physiologically to support selectin-mediated cell adhesion is still not clear. Interestingly, evidence is accumulating that indicates that PSGL-1 may be a physiological ligand for L-selectin and may participate in some E-selectin-dependent adhesion.
Adhesion molecules are vital for the physiological processes of leukocyte trafficking and are critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The studies on selectins and their ligands have yielded an insight to potential therapies for many diseases. Indeed, interference with selectin function is an attractive way to potentially block inflammation at a very early step. Although most intervention studies to date have been performed in animal models, human studies also have indicated a significant role for selectins and their ligands in the inflammatory response. In the following section we review select studies demonstrating a role for selectins in inflammatory injury in different organs.
4.1. Brain
Human studies have shown increased selectin levels in ventricular cerebrospinal fluid (CSF) from children with severe traumatic brain injury (Glasgow coma score < 8) (28) and in patients with relapsing-remitting multiple sclerosis (29). Middle cerebral artery occlusion in non-human primates is associated with upregulation of E-selectin (30). Selectins are also thought to contribute to tissue injury in stroke. In multiple murine models of stroke, the use of selectin ligands to block selectin function has reduced infarct size (31-33) (Table 2).
Table 2. Selectin studies in brain
4.2. Heart
Leukocyte adhesion to damaged endothelium is enhanced in the presence of platelets by a mechanism involving platelet P-selectin. Thrombus formation may also be enhanced by this interaction. In human studies, P-selectin levels were shown to be significantly increased in plasma in patients with acute myocardial infarct (34). The use of a selectin blocker (CY-1503), an analogue of sialyl Lewis X selectin ligand, inhibited leukocyte and platelet interaction after arterial injury produced by angioplasty in pigs (35). Other studies have shown that the selectin blocker fucoidin provides cardioprotection in rats and dogs with coronary artery occlusion (36). These promising results may be the precursors of clinical trials of selectin blockers in humans (Table 3).
Table 3. Selectin studies in Heart
4.3 Kidneys
Unlike in heart and muscle, L-selectin alone does not appear to mediate leukocyte recruitment to postischemic kidney (37). P-selectin, however, is upregulated in renal ischemia-reperfusion injury (38). Initial results with P-selectin antibody were protective in rats post renal ischemia (39). A soluble P-selectin glycoprotein ligand, which blocks P and E-selectins, has been shown to decrease renal injury secondary to ischemia-reperfusion in mice models (40). Blocking initial selectin-mediated events that accompany renal ischemia-reperfusion has also been shown to reduce late renal dysfunction and tissue damage (41). Thus, selectin blockade might be a potential therapeutic intervention in the transplantation of kidneys from non-heart-beating donors and in kidneys subjected to prolonged ischemic times. Recently small molecule blockade of selectin ligands substantially reduced renal injury and improved mortality in rats. Interestingly, this occurred independent of neutrophils infiltration (42) (Table 4).
Table 4. Selectin studies in Kidneys
4.4. Lungs
In a sheep model of ischemia-reperfusion, antibodies directed against both L- and E-selectin significantly reduced pulmonary leakage and neutrophil accumulation (43). In a lung transplant model, anti-E- and anti-L-selectin antibodies improved post-transplant pulmonary function tests (44). Similarly, an analog of sialyl lewis X was found to reduce allograft rejection and reperfusion injury in a lung transplant model (45) (Table 5).
Table 5. Selectin studies in Lungs
4.5. Liver
Studies of selectin involvement in liver ischemia-reperfusion injury have focused primarily on P-selectin and its ligands. Rat studies have shown that P-selectin is the primary determinant of leukocyte adhesion to endothelial cells (46). Other studies have shown reduced liver injury and improved survival in rats treated with anti P-selectin antibodies during hepatic ischemia-reperfusion injury produced by uncontrolled hemorrhagic shock (47) (Table 6).
Table 6. Selectin studies in Liver
5. Novel Perspectives
There is now ample evidence that selectins are important mediators of ischemia-reperfusion injury in a number of different organs. Recent data also suggest that targeting selectin ligands may be a valuable therapeutic approach in the treatment of ischemia-reperfusion injury. The mechanisms underlying the protective effect of selectin antagonism in organ ischemia-reperfusion appear to be more complex than merely reducing neutrophil migration into reperfused tissue. Indeed, recent studies have suggested that blocking leukocyte adhesion molecules, including selectins, can protect against inflammatory injury independent of blocking tissue leukocyte infiltration. Interfering with the leukocyte adhesion molecule very late antigen-4 (VLA-4) on eosinophils and lymphocytes was found to attenuate late airway responses in an asthma model despite little effect on the migration of leukocytes into airway tissues (48).
It is possible that selectin antagonism may exert a protective effect during ischemia-reperfusion by interfering with cell signaling. Intriguingly, it has recently been reported that administration of glycyrrhizin, a licorice plant (Glycyrrhiza radix) derivative, decreased renal ischemia-reperfusion injury in a rabbit model (49). Moreover, the authors proposed that the protective effect of glycyrrhizin was due to selectin antagonism, which has been reported for glycyrrhizin (50). Glycyrrhizin inhibits 11b -hydroxysteroid dehydrogenase, the enzyme that converts cortisol to cortisone. Thus, could the protective role of selectin blockade in organ ischemia-reperfusion injury be somehow related to modulation of glucocorticoid activity?
It is clear that further investigation is warranted to elucidate the mechanisms by selectins mediate ischemia- reperfusion injury, beyond simply promoting leukocyte recruitment. In addition, given the ample evidence that now exists regarding efficacy of selectin antagonism in treating organ ischemia-reperfusion injury, clinical trials are justified to translate these basic research findings to clinical utility. However, there are crucial questions to be answered before any human clinical trials, including: (1) What are the effects of selectin interventions on the immune system?, and (2) Is it possible to selectively block just the detrimental effects of leukocyte adhesion molecules without leaving an individual immunocompromised?
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14. Griffin JD, O. Spertini, T. J. Ernst, M. P. Belvin, H. B. Levine, Y. Kanakura & T. F. Tedder: Granulocyte-macrophage colony-stimulation factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J Immunol 145, 576-584 (1990)
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17. Tedder TF, D. A. Steeber, A. Chen & P. Engel: The selectins: vascular adhesion molecules. FASEB J 9, 866-873 (1995)
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21. Moore KL, N. L. Stults, S. Diaz, D. F. Smith, R. D. Cummings, A. Varki & R. P. McEver: Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol 118, 445-456 (1992)
22. Norgard KE, K. L. Moore, S. Diaz, N. L. Stults, S. Ushiyama, R. P. McEver, R. D. Cummings & A. Varki: Characterization of a specific ligand for P-selection on myeloid cells. A minor glycoprotein with sialylated O-linked oligosaccharides. J Biol Chem 268, 12764-12774 (1993)
23. Lorant DE, R. P. McEver, T. M. McIntyre, K. L. Moore, S. M. Prescott & G. A. Zimmerman: Activation of polymorphonuclear leukocytes reduces their adhesion to P-selectin and causes redistribution of ligands for P-selectin on their surfaces. J Clin Invest 96, 171-182 (1995)
24. Hidari KI, A. S. Weyrich, G. A. Zimmerman & R. P. McEver: Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem 272, 28750-28756 (1997)
25. Maly P, A. Thall, B. Petryniak, C. E. Rogers, P. L. Smith, R. M. Marks, R. J. Kelly, K. M. Gersten, G. Cheng, T. L. Saunders, S. A. Camper, R. T. Camphausen, F. X. Sullivan, Y. Isogai, O. Hindsgaul, U. H. von Andrian & J. B. Lowe: The a(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell 86, 643-653 (1996)
26. Dulkanchainun TS, J. A. Goss, D. K. Imagawa, G. D. Shaw, D. M. Anselmo, F. Kaldas, T. Wang, D. Zhao, A. A. Busuttil, H. Kato, N. G. Murray, J. W. Kupiec-Weglinski & R. W. Busuttil: Reduction of hepatic ischemia/reperfusion injury by a soluble P-selectin glycoprotein ligand-1. Ann Surg 227, 832-840 (1998)
27. Borges E, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann & D. Vestweber: P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. J Exp Med 185, 573-578 (1997)
28. Whalen MJ, T. M. Carlos, P. M. Kochanek, S. R. Wisniewski, M. J. Bell, J. A. Carcillo, R. S. Clark, S. T. Ke Kosky & P. D. Adelson: Soluble adhesion molecules in CSF are increased in children with severe head injury. J Neurotrauma 15, 777-787 (1998)
29. Duran I, E. M. Martinez-Caceres, J. Rio, N. Barbera, M. E. Marzo & X. Montalban: Immunological profile of patients with primary progressive multiple sclerosis. Expression of adhesion molecules. Brain 122, 2297-2307 (1999)
30. Haring EP, E. L. Berg, N. Tsurushita, M. Tagaya & G. J. Del Zoppo: E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia. Stroke 27, 1386-1391 (1996)
31. Huang J, L. J. Kim, R. Mealey, H. C. Marsh Jr., Y. Zhang, A. J. Tenner, E. S. Connolly Jr. & D. J. Pinsky: Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science 285, 595-599 (1999)
32. Morikawa E, S. M. Zhang, Y. Seko, T. Toyoda & T. Kirino: Treatment of focal cerebral ischemia with synthetic oligopeptide corresponding to lectin domain of selectin. Stroke 27, 951-955 (1996)
33. Zhang RL, Z. G. Zhang, M. Chopp & J. A. Zivin: Thrombolysis with tissue plasminogen activator alters adhesion molecule expression in the ischemic rat brain. Stroke 30, 624-629 (1999)
34. Tomoda H & N. Aoki: Plasma soluble P-selectin in acute myocardial infarction: effects of coronary recanalization therapy. Angiology 49, 807-813 (1998)
35. Merhi Y, P. Provost, P. Chauvet, J. F. Theoret, M. L. Phillips & J. G. Latour: Selectin blockade reduces neutrophil interaction with platelets at the site of deep arterial injury by angioplasty in pigs. Arteriol Thromb Vasc Biol 19, 372-373 (1999)
36. Ritter LS, J. G. Copeland & P. F. McDonagh: Fucoidin reduces coronary microvascular leukocyte accumulation early in reperfusion. Ann Throc Surg 66, 2063-2071 (1998)
37. Rabb H; Ramirez G; Saba SR; Reynolds D; Xu J; Flavell R; Antonia S: Renal ischemic-reperfusion injury in L-selectin-deficient mice. Am J Physiol 271, 408-13 (1996)
38. Zizzi HC, G. B. Zibari, D. N. Granger, I. Singh, L. D. Cruz, F. Abreo, J. C. McDonald & M. F. Brown: Quantification of P-selectin expression after renal ischemia and reperfusion: J Pediatr Surg 32, 1010-1013 (1997)
39. Rabb H, C. Mendiola, S. R.. Saba, J. Dietz, C. W. Smith, J. V. Bonventre & G. Ramirez: Antibodies to P-selectin and ICAM-1 protect kidneys from ischemic-reperfusion injury. JASN 5(3), 907 (1994)
40. Singbartl K; Green SA; Ley K: Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 14(1),48-54 (2000)
41. Takada M, K. C. Nadeau, G. D. Shaw & N. L. Tilney: Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding. Transplantation 64, 1520-1525 (1997)
42. Nemoto T, A. C. Issekutz, K. Berens, M. O'Donnell, B. Kasiske, W. Keane, H. Rabb: Small molecule inhibition of selectin ligands reduces mortality and improves renal recovery from ischemic reperfusion injury in rats. JASN 10, 637A (1999)
43. Seekamp A, G. Regel, K. Rother & M. Jutila: The effect of anti-L-selectin (EL-246) on remote lung injury after infrarenal ischemia/reperfusion. Shock 7, 447-454 (1997)
44. Brandt M, K. Boeke, M. L. Phillips, G. Steinhoff & A. Haverich: Effect of oligosaccharides on rejection and reperfusion injury after lung transplantation. J Heart Lung Transplant 16, 352-359 (1997)
45. Demertzis S, F. Langer, T. Graeter, A. Dwenger, T. Georg & H. J. Schafers: Amelioration of lung reperfusion injury by L- and E-selectin blockade. Eur J Cardiothorac Surg 16, 174-180 (1999)
46. Sawaya Jr D E, G. B. Zibari, A. Minardi, B. Bilton, D. Burney, D. N. Granger, J. C. McDonald & M. Brown: P-selectin contributes to the initial recruitment of rolling and adherent leukocytes in hepatic venules after ischemia/reperfusion. Shock 12, 227-232 (1999)
47. Rivera-Chavez F, L. H. Toledo-Pereyra, D. T. Nora, B. Bachulis, F. Ilgenfritz & R. E. Dean: P-selectin blockade is beneficial after uncontrolled hemorrhagic shock. J Trauma 45, 440-445 (1998)
48. Rabb HA; Olivenstein R; Issekutz TB; Renzi PM; Martin JG: The role of the leukocyte adhesion molecules VLA- 4, LFA-1, and Mac-1 in allergic airway responses in the rat. Am J Respir Crit Care Med 149(5), 1186-91 (1994)
49. Subramanian S; Bowyer MW; Egan JC; Knolmayer TJ: Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model. Am J Surg 178(6), 573-6 (1999)
50. Kim MK;. Brandley BK; Anderson MB; Bochner BS: Antagonism of selectin-dependent adhesion of human eosinophils and neutrophils by glycomimetics and oligosaccharide compounds. Am J Respir Cell Mol Biol. 19(5), 836-41 (1998)


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CEO Students Hold Trade Show
The Riverbend CEO Program held its annual trade show last night in Alton. Students from three Riverbend high schools presented their 11 start-up small businesses to the public as a closing project for their class. More than 100 people stopped by to visit the booths and do businesses with the young entrepreneurs.
CEO Program facilitator Katie McBee tells the Big Z with two years now in the books she's looking forward to seeing continued growth in the program:
Click here to listen to the recording.
McBee says this class has a few more weeks to go before they wrap up, and acceptance letters for next years class are going out in early May. Students from Alton High, Marquette Catholic and East Alton Wood River will again take part for the 2018-19 school year.


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Cyber security Karan todayAugust 6, 2019 337
On July 28th 2019, Dominik Penner (@zer0pwn) released a vulnerability on GitHub which exploits the Desktop Environment Plasma by KDE.
Using a specially crafted .desktop file a remote user could be compromised by simply downloading and viewing the file in their file manager, or by drag and dropping a link of it into their documents or desktop.
~ @zer0pwn
The vulnerability can be used to achieve Remote Command Execution by just opening the directory. The configuration syntax of KDE allows dynamic configuration entries without any sanitation or what-so-ever. The function KConfigGroup::readEntry() is made to read the entries in [Desktop Entry] tag. The function then calls KConfigPrivate::expandString() which is a core component to this exploit.
KDE Plasma reads the .desktop & .directory file which contain description about the folder, which gets read by the GUI every time the user goes into a directory with a File Browser. Simply by putting the malicious code as the value of 'Icon' in the [Desktop Entry] will result into execution of it.
Dominick on his GitHub has also provided the affected code along with the Proof of Concept, which is responsible for the command injection. Namely the files kdesktopfile.cpp, kconfiggroup.cpp and kconfig.cpp are affected. The versions that are affected by it are 5.60.0 and below. KDE as of yet hasn't released any sort of update which fixes this issue.
The above video by Dominick shows the Proof of Concept in action.
Written by: Karan
Tagged as: Exploit, 0day, RCE.


text:
Responsive Website Designer
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Outstanding design and development associate each other, which is why we work apace with our team of web developers to generate websites that can be retrieve effortlessly on any device duration maintaining outstanding user action without losing services.


text:
Held on:
January 20, 2005 and January 31, 2005
David M. Gilkes
Manager, Registrant Regulation
Capital Markets Branch
Matthew Britton
For the Staff of the Commission
Leslie Daiter
Ellen J. Bessner
For All-Canadian Management Inc.
1. All-Canadian Management Inc. (ACMI) was first granted registration in the category of investment counsel and portfolio manager (ICPM) in 1974. ACMI and its predecessors, Vancouver and Ancaster Management (Vanam) and Central Group, have been managing mutual funds since 1954.
2. On December 29, 2004, Staff of the Ontario Securities Commission (OSC) sent a letter to Russell Boychuk, President of ACMI, notifying him that OSC Staff had recommended the Director refuse to grant the renewal of registration of ACMI on January 1, 2005. OSC Staff cited the following reasons for refusing registration:
1. No financial statements have been filed for any of the University Avenue Funds since June 30, 2003;
2. There are currently no "live" prospectuses to sell any of the University Avenue funds or the All-Canadian Money Market Fund, and;
3. Effective May 5, 2004 ACMI has been subject to terms and conditions on its registration that require it to file certain financial statements on a monthly basis with the Compliance section of the OSC. These filings have repeatedly been filed late.
3. After receiving the letter from Staff, Mr. Boychuk requested an Opportunity to be Heard (OTBH) by the Director pursuant to subsection 26(3) of the Act that states:
(3) Refusal -- The Director shall not refuse to grant, renew, reinstate or amend registration or impose terms and conditions thereon without giving the applicant an opportunity to be heard.
4. The OTBH was conducted through oral hearings on January 20, 2005 and January 31, 2005.
5. Counsel for OSC Staff provided information that expanded the reasons for the recommendation that the Director refuse to grant registration to ACMI. This included information obtained by OSC Compliance OSC Staff from a meeting with Mr. Boychuk at the premises of ACMI in Ancaster, Ontario on January 7, 2005.
6. Counsel for ACMI, through the testimony of Mr. Boychuk and through exhibits, explained and clarified the findings of OSC Staff. In addition, a great deal of background into the former owners and their business practices, unknown to OSC Staff was provided.
7. I will not record in this decision all the evidence presented during the OTBH as much of the information placed context around the actions that were undertaken by ACMI. The key elements of the submissions and other relevant information are addressed below.
Investment in ACMI
8. In November 2002, Mr. Boychuk acquired a 20% interest in ACMI. Up to that time ACMI had been owned 75% by the Loyalist Insurance Group (Loyalist) and 25% by Accrete Corporation Limited (Accrete). Loyalist had been a shareholder in ACMI since 1999, prior to that time Accrete was the sole shareholder of ACMI.
9. At the time that he made the investment, Mr. Boychuk had retired from the investment industry and was asked by Loyalist to join ACMI. Although Mr. Boychuk had undertaken some due diligence he did not appreciate the seriousness of the situation at ACMI until after he had put his money into the firm.
10. Mr. Boychuk and his business partner, Harold Kent, intend to purchase the outstanding shares of ACMI from Loyalist and Accrete. It is anticipated that they will each own 50% of ACMI once the transaction closes.
Business Practices and Environment at ACMI
11. Submissions from both OSC Staff and ACMI indicate that ACMI could not have continued as a going concern without a change in its business strategy. There had only been about 30 new sales of units in the All-Canadian funds over the last 25 years.
12. The only new revenue coming into ACMI had been through its alliance with the Coleford Investment Counselors of Toronto (Coleford). Coleford is the subadviser of a fund managed by ACMI. There have been sales of about $2.5 million over the past 18 months in this fund.
13. Mr. Boychuk discovered a number of irregularities when he started looking into the daily operations of ACMI. These irregularities included: salaries paid to individuals who were not doing any work at ACMI, trailer commissions paid to firms or persons not registered with the OSC or other securities commissions, expenses paid by ACMI for affiliated companies, and approximately 1,400 dormant accounts which dated back over 40 years.
14. Mr. Boychuk tried to correct these practices and he found himself in an adversarial relationship with his partners and OSC Staff at ACMI. When Loyalist acquired a share of ACMI, it agreed to give five people long term contracts. Mr. Boychuk found himself at odds with these employees after he joined the firm.
15. In February 2004, Mr. Boychuk became Managing Director and took over the position of CFO at ACMI. At this time he started to come to the office everyday and found further irregularities.
16. In March 2004, Mr. Boychuk became President of ACMI. At that time, Mr. Boychuk took additional steps to learn if there were any other irregularities in the operations of ACMI. He conducted an internal audit and changed auditors and law firms. In addition, there was a complete turnover of staff at ACMI. Previous staff started to resign when Mr. Boychuk took over as President.
Financial Monitoring
17. ACMI had terms and conditions imposed on its registration since May 6, 2004. Under these terms and conditions, ACMI is required to file certain financial statements on a monthly basis with OSC Compliance Staff.
18. Over the seven months through to the end of 2004, ACMI has filed the required reports but on five occasions they were filed late. The terms and conditions require that these statements be filed within 3 weeks of the end of each month. OSC Staff submitted that this time frame is ample to allow for the preparation of such statements and even more so in the case of ACMI given its low number of transactions and relatively modest finances.
19. The financial statements for the first month following the imposition of the terms and conditions were filed by the June 21, 2004 deadline. Subsequently almost all the statements were filed late.
20 Mr. Boychuk explained that the fund accountant at ACMI, one of the employees carried over from the Accrete days, resigned on July 1, 2004. Following the resignation of the accountant Mr. Boychuk started to maintain the accounting records. However, the former accountant did not leave passwords for certain files and had taken two computer hard drives when she left.
21. ACMI hired a new accountant in September 2004. The new accountant found numerous problems with the books and records at ACMI.
22. ACMI has since upgraded its computer systems, has regained access to all its files and the new OSC Staff are more familiar with the organization. Mr. Boychuk said he does not intend to have any further late filings and believes that ACMI will meet the financial monitoring terms and conditions going forward.
Capital Adequacy
23. During the on-site meeting with Mr. Boychuk at ACMI on January 7, 2005, OSC Compliance Staff expressed concern that the capital adequacy calculations contained items that should not have been included. OSC Staff found that if these items were removed, ACMI would be capital deficient.
24. ACMI has reviewed its calculations with its auditors and they agreed that the calculations were not computed correctly. Mr. Boychuk said that ACMI does have sufficient capital to meet the requirements of the Securities Act (the Act). He noted that the new shareholders will put more money into the company once they have completed the acquisition.
Dormant Accounts
25. Mr. Boychuk was not aware of the dormant accounts when he bought into the company and only learned of the dormant accounts shortly after becoming Managing Director of ACMI. According to Mr. Boychuk, Loyalist was not aware of the dormant accounts when it became the major shareholder.
26. After becoming aware of the dormant accounts, Mr. Boychuk took steps to quantify the value of these accounts. There were approximately 1,450 dormant accounts valued at about $3.7 million. This represented about 66% of the clients and 30% of the asset base of the All-Canadian Funds.
27. All the dormant accounts related to the All-Canadian funds and not the University Avenue Group of funds or the Coleford fund. As some of the All-Canadian funds had started in 1954, some of the dormant accounts were over 40 years old.
28. Mr. Boychuk indicated that there is no uniform law in Canada for the treatment of dormant accounts and in Ontario there is no specific legislation on point. In absence of any governing law, Mr. Boychuk reviewed the practices of other companies relating to dormant accounts and unclaimed property. He checked with Standard Life, Franklin Templeton, and AIM Trimark. Mr. Boychuk found that depending on the province after either one year or three events of returned cheques, unclaimed amounts of $100 to $300 could be taken into income. However, the unit holder still retained the right to redeem at some later date.
29. ACMI wanted to obtain a new prospectus for the funds and to do so it had to redeem the dormant accounts. The dormant accounts were moved over to four interest bearing trust accounts at CIBC. There are separate accounts for the All-Canadian Consumer fund, the All-Canadian Capital fund, the All-Canadian Compound fund and the All-Canadian Resources fund. There are approximately $3 million in the combined accounts.
30. ACMI has a systematic approach to tracking down the dormant account holders starting with the largest amounts. However, this could be a full-time job. Once all efforts to find a dormant account holder have been exhausted the amount will be redeemed. ACMI will then distribute the money to charity.
31. There is one exception to the above. Vanan redeemed a number of dormant accounts in 1974 and placed the funds in an account named Vanan and then ACMI. There are no records of the original accounts redeemed. Mr. Boychuk indicated that this account will be taken into income and the appropriate taxes paid.
32. While all these steps have been taken it was noted by OSC Staff that approximately 50 accounts had been settled since July 2004. OSC Staff was concerned with the seemingly little progress in rectifying this issue.
33. Mr. Boychuk noted that the volume and age of the dormant accounts presented ACMI with a unique problem. He stated that while it is important that the accounts are handled fairly and in the best interests of the clients, ACMI must continue to focus on operating and growing its business. However, he indicated that some resources will be dedicated to finding the beneficial owners of the accounts.
University Avenue Funds
34. ACMI was in negotiation with Avenue Financial to buy the University Avenue Funds in January 2003 but ACMI backed out in the spring of 2003 for various reasons. Avenue Financial approached ACMI again in December of 2003 in relation to taking over the University Avenue Funds.
35. ACMI decided to take over the University Avenue Funds for two reasons. First, Avenue Financial paid ACMI $20,000 ($10,000 for legal expenses and $10,000 on closing) to take over the funds. Second, ACMI had received interest from High Street Funds in University Avenue's balanced fund. ACMI was also interested in the University Avenue Money Market Fund and renamed it the All-Canadian Money Market Fund.
36. However, when ACMI tried to get the books and records for the funds, it found that many records did not exist. The record keeping was so poor that the accountants could not complete the audit. The poor records applied to all University Avenue Funds including the money market fund, as a result, ACMI decided to wind-up all the University Avenue Funds.
37. OSC Staff had believed that the unit holders of the University Avenue Funds had not received proper notice of the wind up of the funds. The evidence produced by ACMI indicates that unit holders were given appropriate notice. All the University Avenue Funds have now been paid out and wound up.
All-Canadian Investor Services
38. All-Canadian Investor Services (ACIS) was the dealer subsidiary of ACMI. ACMI decided to close ACIS as it had no clients.
39. ACIS is a member of the Mutual Fund Dealers Association and it must have an audit before resignation from membership will be granted. The audit was scheduled to start on February 14, 2005.
Business Plan of ACMI
40. The evidence presented by OSC Staff, the business environment that had existed at ACMI described by Mr. Boychuk, the large number of dormant accounts and the low number of new sales over the past 25 years, raise questions as to whether ACMI is a going concern.
41. At the second day of the OTBH, Mr. Boychuk entered ACMI's business plan as an exhibit. The business plan builds on the success that ACMI has had with the Coleford Fund. The plan, while not detailed, provides a fairly clear direction of where ACMI is heading.
42. Based on all the evidence presented, I believe that ACMI should continue its registration but it should be monitored closely. Therefore, the terms and conditions attached as Schedule A shall be imposed on the registration of ACMI.
43. The terms and conditions in Schedule A were developed by OSC Staff in consultation with ACMI management to ensure that they balanced the requirements under the Act with ACMI's ability to operate its business.
44. ACMI is required to provide reports on a regular basis and to meet certain milestones set out in the terms and conditions. ACMI will maintain its registration provided it meets the terms and conditions to the satisfaction of OSC Staff. Should ACMI fail to meet any milestone or provide reports, the Director may decide not to renew the registration of the firm.
45. ACMI must continue to meet all other requirements under the Act that apply to it as a registrant. The terms and conditions will be removed from its registration once ACMI has met all the milestones in Appendix A to the satisfaction of Staff.
May 5, 2005
"David M. Gilkes"
Schedule A
1. Registration of the Firm will continue until either:
a. the Director determines that the Firm has failed to satisfy one or more of these terms and conditions, in which case the registration of the Firm may be suspended at the discretion of the Director; or
b. the Director determines that all of these terms and conditions have been satisfied, in which case these terms and conditions will be removed.
2. No later than May 15, 2005, the Firm shall have submitted, via the National Registration Database, an application satisfactory to the Director for the registration of Mr. Kent as an officer, director and shareholder of the Firm.
Wind-up of All-Canadian Investor Services Inc. (ACIS)
3. No later than May 15, 2005, the Firm shall have engaged the services of a third party accounting firm acceptable to the Manager, Compliance to conduct a closing audit of its wholly-owned subsidiary, ACIS.
4. No later than July 15, 2005, the firm shall have completed the wind-up of ACIS.
Wind-up of the University Avenue Funds (the University Funds) and the All-Canadian Money Market Fund (the Money Market Fund)
5. No later than May 15, 2005, the Firm shall have completed the wind-up of the University Funds in compliance with all applicable requirements of National Policy 51 - Changes in the Ending Date of a Financial Year and in Reporting Status of an Investment Fund (NP 51).
6. No later than June 15, 2005, the Firm will have completed the wind-up of the All-Canadian Money Market Fund in accordance with its trust indenture, National Instrument 81-102 - Mutual Funds (NI 81-102) and NP 51.
Merger of the All-Canadian Capital Fund (the Capital Fund) and the All-Canadian Compound Fund (the Compound Fund)
7. No later than June 15, 2005, the Firm will have either:
a. submitted to the Senior Accountant, Compliance documents establishing that it has complied with the requirements of Section 5.6 of NI 81-102; or
b. filed an application pursuant to Section 5.7 of NI 81-102 seeking regulatory approval to facilitate the merger of the Capital Fund and the Compound Fund.
8. No later than September 15, 2005, the Firm will have completed the merger of the Capital Fund and the Compound Fund in compliance with all applicable requirements of NI 81-102 and NP 51.
Dormant Accounts
9. No later than May 15, 2005, the Firm shall have submitted a written plan (the Plan) acceptable to the Director for the reunification of dormant account assets with their beneficial owners. The Plan shall include, among other items, a proposal for the disposition of assets in respect of which beneficial owners cannot be located.
10. No later than July 15, 2005, the Firm shall have submitted a written quarterly progress report to the Senior Accountant, Compliance with respect to the Plan. Further progress reports shall be submitted no later than the 15th day following the end of each quarter for the duration of the Plan.
Financial and other Reporting
11. No later than the 15th day of each month, the Firm shall file the following information with the Senior Accountant, Compliance:
a. year-to-date unaudited financial statements, including a balance sheet and income statement prepared in accordance with generally accepted accounting principles;
b. a calculation of minimum required capital as of the last day of the preceding month; and
c. copies of all trust account statements from the preceding month relating to dormant accounts, as well as all supporting documents relating to any withdrawal or transfer of funds out of any such account.
Further Information
12. No later than the 15th day of each month, the Firm shall file the following information with the Manager, Registrant Registration:
a. written notices of any progress in regard to the Firm's proposed business transactions as outlined in the Firm's business plan presented to the Director in January 2005; and
b. any letters of intent entered into with any third party.__________________


text: Where I come from, it is not unusual to see tiger tails hanging from the back of cars every Saturday with a home game. However, I have never seen an arm hanging from the back of taxi and I can imagine it would get quite a few second looks. I love this advertisement, but I would like to see the ad on the top of the taxi also be for the sopranos (kind of hard to tell from this picture) The bumper sticker is perfectly placed, but might be hard to see without getting pretty close to the taxi. This certainly falls under buzz marketing!


text:
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Discover Inspiring Contents at a click
The Intuitive search layout helps you locate the most relevant content on any subject that's trending on social networking pages or blogs. It is possible to hand-pick any content which is popular and is rated high by social networking.
This allows you to dig into the content jewels that are hidden under the sea of contents. With your own set of keywords, you can set up topics that help in fetching suitable contents.
Easiest Multi-Social Media Management:
Make your Contents engaging and update your blogs and social channels with the best contents which folks really like to read and share. Trend contents until it tendency anywhere and fill your account with images, videos and much more to acquire many likes.
A Good Deal of time is wasted in logging in to various social accounts and Uploading exactly the identical content, image or videos. However, with ContentStudio's instinctive tool, you can save your time which was wasted for logging in to various accounts and rather with a click of a button manage all of the accounts, pages and groups using one stage. With this platform that is intuitive, handling social media is simple and worry-free.
Craft new contents with Composer:
Composer module assists you create fresh contents taking less time for Your sites or social media pages. With too much of competition in the market, individuals upgrade posts very frequently. This instrument will suggest you what to post next on your social account or blog page. With drag & drop editor it is easy to add photographs, videos and posts to your social accounts conserving much of your precious time.
Powerful Automation & planner
The strong Search engine searches across 9+ sources like Facebook, Twitter, YouTube, Dailymotion, Imgur, Giphy, Flickr and Pixabay.
So the tool is not just limited to contents, but also images and videos Can be searched. You can get a history of the contents that were trending within the last few hours or days and engage with your customers with the best materials within your specialty or area.
Works together with the Collaboration of numerous online apps:
Plenty of third-party integrations are available to Make Sure your new Contributes to the tools used by you personally. With Variety of integrations such as Facebook, Twitter, Linkedin, Tumblr, Pinterest, Medium, WordPress, Pocket, YouTube, Dailymotion, Pixabay, Flickr, Imgur, Giphy, Adobe Creative, Bit.ly, Goo.Gl, Replug, ChimpRewriter, SpinRewriter, and WordAi.
One Dashboard for everything:
Seamlessly organize everything from one location. All the puzzles are Connected together to help you organize and increase the productivity. You can edit and review articles before being published with the help of this interactive content calendar. The whole weeks or month's content is facing you, and you can control it as you would like. Easily collaborate the work from team members with power to accept or reject articles and automate campaigns from within the calendar. From a single place, you can handle to publish contents onto a blog or social media in a calendar view or list view.
SEO Optimized Contents Forever:
Real time SEO is implemented while writing a Blog post and can be optimized to save time that's wasted on search-engine SEO. It's possible to schedule some articles to repeat in your social pages with few clicks. This grabs more viewers and engages them to invest more time on your posts. If your intended audience belongs to another region/country, then your contents can be translated to the particular country/region language. Automate Social Media Posts
ContentStudio gives you the option to use naked URLs (no shortening or tracking) in societal places. If you prefer a link shortener and/or monitoring skills, then you've got the selection of ContentStudio's very own abbreviated links (Cstu.io), the renowned Bit.ly link shortening service, and Google's service (Goo.gl)
Adding Content Resources
You can add keywords or domain names to monitor as resources to appear from the content discovery segment. Another great feature is the ability to add RSS feeds into your own content sources. And if you prefer the content produced by specific Facebook pages, then add them as sources also so they look first.
As soon as you've added social networking reports, set connected accounts together to make scheduling a little simpler. Should you work with clients or you have multiple companies, it makes sense to add accounts from each company to a group. Use the Settings > Groups option.
Creating Content for Sharing
At the top right of the ContentStudio Port is the Compose button. Click it to start a new page with just two options: Blog Post or Social Media Post.
I am Not a fan of the (talk to) Blog Post functions since I prefer to use WordPress's native interface. However, it can be a timesaver if you maintain multiple blogs as you can compose and publish articles without logging in and navigating to the New Post area of WordPress
The Composer instrument is feature-rich, offering The full gamut of formatting options and the ability to haul links and content from subjects you searched for. For anyone interested in generating newsletter kind articles or curated articles, this is a Fast way to do it.Screen Recording 2018-02-24 in 10.48 a.m..gif
Content Discovery
This is one of the areas where ContentStudio really shines. The Content Discovery section is excellent for finding trending articles across multiple platforms immediately. Presently, the searchable platforms or Internet places are:
Internet Articles — Search the web for articles and news items on your intended subject or use the'trending' search for inspiration.
YouTube — Instantly find hot Youtube videos together with viewer count, likes, and comments.
Dailymotion — Like Youtube, Dailymotion is another search engine for movie articles
Facebook — Find the trending themes or favorite articles on the planet's biggest social media
Twitter — Discover, discuss, and retweet tweets which have gone viral.
Flickr — Search for photos on Flickr without logging to the platform
Imgur — ContentStudio's integration is not yet ready for prime time but it's a fantastic way to get some thoughts
Giphy — The platform for Gifs is a goldmine for shareable pictures
Pixabay — Find free-to-use images for your content or social media posts.
The Granularity given by the software is very impressive. Not only can you look unique platforms, but you can also pick timeframe, geographical location, language, most shared, trending, by shares, topics, and length. Automate Social Media Posts
Want some shareable content on Facebook Ads that has been posted on the web in the last week, in the united kingdom, in English, that is also trending, and contains plenty of Facebook shares?
SEO Score
Assess The SEO score of your article before submitting with the'Check Score' feature in the bottom from the Composer window.
Post Preview
Creating A social networking post work in a similar way to the Blog Post alternative but includes a few more options and tools.
Search For articles and drag it to the editor for scheduling or posting. Or write your social media article and add your own images, layouts, or videos. The social media platforms now supported are Facebook, Twitter, Pinterest, Linkedin, and Tumblr. Google Plus and Instagram are on the road.
You have got 4 options for posting:
1. Post Now — Does what it says on the tin. Send That article out into the world right away. Selecting this choice (and the Program option) gives you the capability to replicate program a post with hourly, daily, weekly, and monthly interruptions.
2. Schedule — Insert the post to some future time slot. You can Additionally repeat program.
3. Queue — Post the upgrade at the next slot decided by The queue. Queue timings are set under Preferences (click on the arrow beside the circle with your initials at the very top right) > Social Accounts > Change Queue Schedule.
4. Evergreen Cue — Add your article to your Evergreen Campaigns. These campaigns are groups of social networking posts that replicate at particular intervals. Excellent for your foundation posts.
If you'd like to change the content for Each platform change off the same material for all slider and edit every social networking account's post to your heart's content. Ideal for adding hashtags to twitter but keeping them out of a Facebook post, for instance. Content on Facebook is also as long as you like.
Below the section where you put in the material For posting, you are going to come across a Preview section, which upgrades as you enter or edit content. Tabs at the peak of the preview window let you change between societal accounts so that you get a visual representation of what the article will look like on each stage. Quite useful.
Help, Notifications, and Advice
What I really like about ContentStudio are the tiny features that guide you as you build your social networking marketing plan. The top of this screen is where you'll discover the newest Changes and Notifications feeds.
Newest Changes is great for discovering what the developers have assembled. You might find some brand new features to utilize. The ContentStudio staff update this on a regular basis.
The Notifications section alerts you if, as an example, an automation effort does not have enough posts lined up. The recommendation might be to include more key words or change your plan.
In the bottom left of the display, you'll discover the Support area. There's a Guided Tour for newbies or anyone that needs a refresher. Automate Social Media Posts
Help Desk is for firing questions in the team. It is also possible to use the chat that appears at the bottom right. The service team is responsive and useful.
Knowledge Base brings you to ContentStudio's documentation that covers most things.
Public Roadmap helps you keep up with new developments. I love this part.
System Status Indicates the current state of the platform. Useful to test if something seems like it's not working. Language Support
Non-English speakers rejoice! ContentStudio works in French, Dutch, German, Spanish, Turkish, Polish, Italian, Portuguese, Swedish, Albanian, Danish, Serbian, Hungarian, Russian, Indonesian, Thai, and Hindi. Plenty to select from, including a few lesser languages that are targeted.
Insert RSS feeds and search for articles in Discovery manner in one of these languages.
ContentStudio.io Offers 100% human-based support round the clock through chat, tickets, and email, Their tech professionals are always there to assist you beyond the limitation for any questions and urgent issues. Apart from the aid, when you log into contentstudio.io, you can start a quick tour which shows you each product attribute and all the measures top begin content marketing and Social Networking optimization,
So to understand all components of cloud-based content Studio program, It is highly recommended to go through the fast product tour to get started.
Each of the programs could be chosen for either monthly or Annually, but annual programs save around 20 percent off, so it is more economical to choose annual programs. It is possible to use the tool for free with no charge card, however the The free version has restricted attributes.
To upgrade More innovative features, you will need to purchase any other plans available to suit all kinds of businesses. During some exclusive shopping seasons like Black Friday, Cyber Monday, Christmas, etc., you will get a massive discount on Contentstudio.io programs, so make certain that you check in these days to save as much as 90% on its own charging.
The free program which comes with 2 social media accounts
Pro plan costs $15/mo and $12/mo if billed yearly.
Small plan prices $47/mo and $41/mo if billed annually.
Moderate plan costs $97/mo and $83/mo if billed annually.
Large program prices $197/mo and $157/mo if billed yearly.
Enterprise program with custom pricing for huge Businesses
Pro Plan is recommended as it suits all demands for In-depth social networking management, automation, content curation and articles marketing planning.
To avail, Some of the plans click on Get Started and fill in the details. Enter the coupon code to get more discount or continue with the payment process by deciding upon any payment system such as Visa, MasterCard, etc.. Click on Pay USD and enjoy the professional services to organize your content marketing needs.
You can Contemplate as many places as you want but the content gem is going to be located only on ContentStudio. It's a studio of high quality content search, pictures, videos, GIF's, etc.. Over 5000+ specialists and 2500+ companies already trust ContentStudio for publishing high-quality articles and managing their societal media accounts & blogs from its intuitive platform. Automate Social Media Posts
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text:
Mini Class Night: January 24 at 7 p.m.
Tuesday, January 22, 2019
What? Mini Class Night
When? Thursday, January 24 from 7 - 8:45 p.m.
Where? Mini Class Night begins in your listed Homeroom on your student's schedule
Class Schedules? Reminder! No student schedules will be printed or available. You will need to download your students schedule before you arrive.
Purpose? The purpose of Mini Class night is to acquaint you with each of your student's teachers and classes.
Classes Length? Classes will be eight minutes in length with four minutes passing time between.
Wi-Fi? The Guest Wi-Fi Password will be available on the TV monitors located throughout campus.
Announcements? Please check your school email account for MCN announcements for the evening. These will be sent Wednesday morning.


text:
If further proof was needed that Sydney is a tough market to launch theatrical productions, then the company behind Dirty Rotten Scoundrels is the latest example.
The show won best musical and best actor in a musical at last year's Sydney Theatre Awards and was lauded in reviews.
But it failed to attract big audiences over its eight-week season at the Theatre Royal.
In late January, the show's producer, 31-year-old newcomer to the Australian scene George Youakim, sent a letter to contractors who were owed money, saying the company could not meet its debts and it would be handed to a liquidator.
''The liquidation process should begin in February, and it is hoped that accounts will be settled as quickly as possible following the signing over of the company to the liquidator,'' Mr Youakim said in a letter.
''Once the company has been signed over, the liquidator will reach out to the creditor and inform you of the process and the estimated payment term and date.''
Mr Youakim said all wages had been paid to the actors and crew, but that some contractors and suppliers were owed money.
''The company has not been placed in liquidation yet,'' Mr Youakim said. ''I am still looking at other alternatives to meet the debt.''
Mr Youakim, who studied musical theatre in New York, had hoped to take Dirty Rotten Scoundrels to Melbourne, which seems to have a more receptive audience for musicals. Jill Hewitt, from Moneypenny, which served as the production accountant, said several shows had struggled in Sydney in recent years.
''Sydney just doesn't spend on theatre tickets the way Melbourne does,'' she said.
A technical director on the show, Greg Yates, said he was owed thousands of dollars for out-of-pocket expenses. ''Once bitten, twice shy,'' he said.


text:
If you're a fan of claiming free cryptocurrency (and referring others to do so), then be sure to check out the latest developments at Cointiply and Coinpot. Both sites have recently added activity-driven rewards, resulting in more...Read More »
Earn Free Crypto with Coinpot
Claiming free cryptocurrency from faucets is free, and with Coinpot it's pretty convenient, too. What is Coinpot? Basically a central micro-wallet for a group of reputable faucets online. You visit the page (yes, there will be lots of ads), complete the captcha code, and instantly collect small amounts of Bitcoin …Read More »


text:
Portable wireless speakers (4 inch)
YELOBUY highest selling Portable wireless speakers for your soul peace.Great Speaker With Best Quality Of Sound. Small in size & BIG on quality. Play radio and enjoy your favorite music directly through Bluetooth, AUX cable, PEN drive or Micro SD card with rechargeable battery. Ideal companion for iPhone's, Smartphone's, iPad's . Once connected with mobile phone through Bluetooth, works as an extended speaker phone too. Excellent device for corporate customers, where it can be used for conference calls. Wireless Portable Bluetooth Speaker – Whether you're Partying, Walking out, Camping, Hiking, Biking, or just lounging around the house, enjoy a full-range stereo sound with a impressive volume. Can be easily carried in your bag when travelling. Easily compatible with All Android and iOs Smartphones.
*The Product Output May Vary As Per The Compatibility Of Different Gadgets Used.The Product's Images Are For Reference Only.T&C Apply.


text: Total Size(not include shaft): 262131255mm(LWH); Shaft Hole Dia: 25mm. Color: As Picture Shows; Weight: 9800g; Package Content: 1 X DC Gear Motor w Turbine + 2 X Reduction Casings. The item "DC24V 100w Auto Control Speed Gear Motor w RV030+063 2 Reduction Casings 1.2rpm" is in sale since Wednesday, September 25, 2013. This item is in the category "Business, Office & Industrial\Automation, Motors & Drives\Electric Motors\General Purpose Motors".The seller is "365bestseller" and is located in China. This item can be shipped worldwide.


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[dropcap]W[/dropcap]eek 19; belly watch continues. Oh, and it's a big WELCOME to December too. Every week, I have the Big Brother voice counting down the week in my head. Today is a hello to week 19- past four months, but not quite five. Last week we put up our Christmas tree. I know! Already! But it just worked out that way, and to be honest, I am very much enjoying it. Almost as much as Pepper's annual Christmas hat photo- doesn't he look like he's loving it? 😉 Oh! and SNOW! I love how happy snow makes everyone in London; we never get decent snowfall, so waking up on Sunday morning to a blanket of white was the best surprise.[vc_row][vc_column width="1/2″][vc_single_image image="18689″ img_size="large" css=".vc_custom_1516884168545{padding-top: 0px !important;}"][/vc_column][vc_column width="1/2″][vc_column_text css=".vc_custom_1516884255072{padding-top: 130px !important;padding-right: 40px !important;padding-bottom: 150px !important;padding-left: 40px !important;background-color: #f8f3f0 !important;}"]
Putting up the Christmas tree early has actually been a good remedy for the winter doldrums. The living room smells of pine and having the lights glow in the evening makes me feel cosy and content…even when two cats start a game of bat the candy canes off the tree. It was nice that we both got to decorate it this year to cheesy Christmas songs (Wham, FYI) and that we get a whole month out of it compared to last year's last minute half panicked- 4 days before Christmas- refurb angry-place the tree next to the a wheel barrow of sand shenanigans…
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Ohhh man. This past week of pregnancy has been like a flashback to the early days. Nausea in the evenings, sudden urges to nap at odd hours of the day, a breakout of spots on my face and the delightful feeling of my belly stretching…It's been an uncomfortable week! Once upon a time, I could sleep through an earthquake, but now all it takes to wake me up in the middle of the night (besides my ever shrinking bladder) is a snort from Pepper. All of this has made me a little cranky in the day time and an absolute joy to be around 🙂 So, Week 19- still waiting on that pregnancy glow.
[/vc_column_text][/vc_column][vc_column width="1/2″][vc_single_image image="18599″ img_size="large" css=".vc_custom_1516884296157{padding-top: 0px !important;}"][/vc_column][/vc_row][vc_row][vc_column width="1/2″][vc_single_image image="18700″ img_size="1000×1000″ alignment="center" css=".vc_custom_1516884503642{padding-top: 0px !important;}"][/vc_column][vc_column width="1/2″][vc_column_text css=".vc_custom_1516884538470{padding-top: 80px !important;padding-right: 40px !important;padding-bottom: 90px !important;padding-left: 40px !important;background-color: #f8f3f0 !important;}"]
I feel like you have to be a whip shot on Asos to get hold of anything nice ( you know what I mean? no surprise cutouts on the back or motifs that don't need to exist) so I snapped up this dress quickly on Sunday night for a wedding I'm going to this weekend. It's since Sold Out but you can get it in burgundy in a mini dress version, or in blue in a maxi dress version here. Or, I'm sure it'll restock as popular pieces tend to do. It's velvety soft, perfect for Winter (and Christmas parties) and the stretchy waistband means that my growing bump can nestle comfortably underneath it. I'm wearing it with a pair of gold tassel earrings from H&M![/vc_column_text][/vc_column][/vc_row][vc_row][vc_column width="1/2″][vc_column_text css=".vc_custom_1516884595676{padding-top: 130px !important;padding-right: 40px !important;padding-bottom: 155px !important;padding-left: 40px !important;background-color: #f8f3f0 !important;}"]
What did you do on your Snow Day yesterday? After waking up early, I pretty much stayed glued to the window watching it fall and releasing the cats into it- they've never seen snow before. Pepper absolutely loved it and Louie…preferred the comforts of home and underfloor heating. It was completely unexpected too, which made it an even bigger treat to wake up to. I don't think I've ever leapt out of bed that early on a Sunday with so much enthusiasm! Now I look out to the sleeting rain and already the lovely snowy day feels like…did that really happen? The last really good snowfall here was 2010, when it stuck around for a good week. Come oooon, let it snow, let it snow, let it snow!
[/vc_column_text][/vc_column][vc_column width="1/2″][vc_single_image image="18703″ img_size="large" css=".vc_custom_1516884553381{padding-top: 0px !important;}"][/vc_column][/vc_row][vc_row][vc_column width="1/2″][vc_single_image image="14561″ img_size="large" css=".vc_custom_1516884609033{padding-top: 0px !important;}"][/vc_column][vc_column width="1/2″][vc_column_text css=".vc_custom_1516884649847{padding-top: 110px !important;padding-right: 40px !important;padding-bottom: 150px !important;padding-left: 40px !important;background-color: #f8f3f0 !important;}"]
Last year, before a festive time on the John Lewis roof top, I did some window shopping in town. Liberty's was beautiful (but also, The Nutcracker is my fav so it was always a winner) This year, I attempted to do a Christmas shopping mooch, thinking I'd get most things done. NOPE.BIG. MISTAKE. I lasted nearly two hours before I fled home on the Victoria line. Pregnancy takes up so much of your energy that I spent most of that time looking for a toilet and watching people dodge past me (I'm also now a slow walker thanks to an increasingly big bump) I couldn't even tell you what Liberty's theme is this year! Although, I do feel like I ought to make a bigger effort to carry my big camera with me from now one because this picture is prettier than anything my iPhone could snap.
[/vc_column_text][/vc_column][/vc_row][vc_row][vc_column][vc_column_text]It's my birthday this week and I'm kind of stuck as to what to do. I prefer keeping it low key with minimal fuss- usually a nice meal at a restaurant. But this year, with baby halving my stomach size (and aversions!) a fancy meal out feels like it might be a bit wasted. To be honest, I'm more excited for our anomaly scan the day after for it means we find out if baby is a boy or a girl! I think once I know, it'll make it feel more real? Like there's an actual human in there and not just a growing belly full of Wotsits.
I re-read my maternity notes recently (all mums to be are given a big yellow book to carry to all your appointments) and I realised the sonographer wrote that I have an anterior placenta, meaning instead of hanging out in the back near my spine, baby and placenta are all at the front wanting to hang out with the world…I *think* that explains why I look bigger than most mums at this stage (or maybe you know…the belly full of Wotsits again)
Anyway, happy Monday chickens. Here's to a couple more weeks until Christmas![/vc_column_text][/vc_column][/vc_row]