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[somatropin (rDNA origin) for injection]
For subcutaneous or intramuscular injection
Saizen® [somatropin (rDNA origin) for injection] is a human growth hormone produced by recombinant DNA technology. Saizen® has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary growth hormone. Saizen® is produced by a mammalian cell line (mouse C127) that has been modified by the addition of the human growth hormone gene. Saizen®, with the correct three-dimensional configuration, is secreted directly through the cell membrane into the cell-culture medium for collection and purification.
Saizen® is a highly purified preparation. Biological potency is determined by measuring the increase in body weight induced in hypophysectomized rats.
Saizen® is a sterile, non pyrogenic, white, lyophilized powder intended for subcutaneous or intramuscular injection after reconstitution with Bacteriostatic Water for Injection, USP (0.9% Benzyl Alcohol). The reconstituted solution has a pH of 6.5 to 8.5.
Saizen® is available in 5 mg and 8.8 mg vials. The quantitative composition per vial is:
5 mg vial:
Each vial contains 5.0 mg somatropin, 34.2 mg sucrose and 1.16 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.
8.8 mg vial:
Each vial contains 8.8 mg somatropin, 60.2 mg sucrose and 2.05 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.
The diluent is Bacteriostatic Water for Injection, USP containing 0.9% Benzyl Alcohol added as an antimicrobial preservative.
Saizen® is also available in the click.easy® reconstitution device. The quantitative composition per vial contained in the click.easy® reconstitution device is:
8.8 mg vial contained in the click.easy® device:
Each vial contains 8.8 mg somatropin, 60.2 mg sucrose and 2.05 mg O-phosphoric acid. The pH is adjusted with sodium hydroxide or O-phosphoric acid.
The diluent contained in click.easy® device is 0.3% (w/v) metacresol in Sterile Water for Injection added as an antimicrobial preservative. The reconstituted solution has a pH of 6.5 to 8.5.
In vitro, preclinical, and clinical testing have demonstrated that Saizen® [somatropin (rDNA origin) for injection] is therapeutically equivalent to pituitary-derived human growth hormone. Clinical studies in normal adults also demonstrated equivalent pharmacokinetics.
Actions that have been demonstrated for Saizen®, somatrem, and/or pituitary-derived human growth hormone include:
Absorption - The absolute bioavailability of recombinant human growth hormone (r-hGH) after subcutaneous administration ranges between 70-90%.
Distribution - The mean volume of distribution of r-hGH given to healthy volunteers was estimated to be 12.0 ± 1.08 L.
Metabolism - The metabolic fate of somatropin involves classical protein catabolism in both the liver and kidneys. In renal cells, at least a portion of the breakdown products is returned to the systemic circulation. The mean half-life of intravenous somatropin in normal males is 0.6 hours, whereas subcutaneously and intramuscularly administered somatropin has a half-life of 1.75 and 3.4 hours, respectively. The longer half-life observed after subcutaneous or intramuscular administration is due to slow absorption from the injection site.
Excretion - The mean clearance of intravenously administered r-hGH in six normal male volunteers was 14.6 ± 2.8 L/hr.
Special Populations
Pediatric - The pharmacokinetics of r-hGH is similar in children and adults.
Gender - No gender studies have been performed in children. In adults, the clearance of r-hGH in both men and women tends to be similar.
Race - No data are available.
Renal Insufficiency - Children and adults with chronic renal failure tend to have decreased clearance of r-hGH as compared to normals.
Hepatic Insufficiency - A reduction in r-hGH clearance has been noted in patients with hepatic dysfunction as compared with normal controls.
A multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted in 115 adults with GHD comparing the effects of Saizen® [somatropin (rDNA origin) for injection] and placebo on body composition. Patients in the active treatment arm were treated with Saizen ® at an initial dose of 0.005 mg/kg/day for one month which was increased to 0.01 mg/kg/day if tolerated for the remaining five months of the study. The primary endpoint was the change from baseline in lean body mass (LBM) measured by dual energy X-ray absorptiometry (DXA) after 6 months. Treatment with Saizen® produced significant (p<0.001) increases from baseline in LBM compared to placebo (Table 1).
Sixty-seven (58%) of the 115 randomized patients were male. The adjusted mean treatment difference on the increase in LBM from baseline was significantly greater in males (2.9 kg) than females (0.8 kg).
Ninety-seven (84%) of the 115 randomized patients had adult onset (AO) GHD. The adjusted mean treatment differences on the increase in LBM from baseline were not significantly different in AO GHD (2.1 kg) compared with childhood onset (CO) GHD (1.0 kg) patients. However, there were relatively few patients with CO GHD (n=18) on which to base the comparison.
Analysis of the treatment difference on the change from baseline in total fat mass (by DXA) revealed a significant decrease (p<0.001) in the Saizen®-treated group compared to the placebo group. Saizen® also produced beneficial effects on several bone turnover markers including bone specific alkaline phosphatase, c-terminal propeptide, osteocalcin, urine deoxypyridinoline and iPTH.
One hundred and eleven patients were enrolled in an open label follow up study and treated with Saizen® for an additional 6-30 months. During this period, the beneficial effects on LBM and total fat mass achieved during the initial six months of treatment were maintained.
Pediatric Patients
Saizen® [somatropin (rDNA origin) for injection] is indicated for the treatment of children with growth failure due to inadequate secretion of endogenous growth hormone.
Adult Patients
Saizen® [somatropin (rDNA origin) for injection] is indicated for replacement of endogenous growth hormone in adults with growth hormone deficiency who meet either of the following two criteria:
Adult Onset: Patients who have growth hormone deficiency, either alone or associated with multiple hormone deficiencies (hypopituitarism), as a result of pituitary disease, hypothalamic disease, surgery, radiation therapy, or trauma; or
Childhood Onset: Patients who were growth hormone deficient during childhood as a result of congenital, genetic, acquired, or idiopathic causes.
In general, confirmation of the diagnosis of adult growth hormone deficiency in both groups usually requires an appropriate growth hormone stimulation test. However, confirmatory growth hormone stimulation testing may not be required in patients with congenital/genetic growth hormone deficiency or multiple pituitary hormone deficiencies due to organic disease.
Saizen® is contraindicated in patients with a known hypersensitivity to somatropin or any of its excipients.
Saizen® reconstituted with Bacteriostatic Water for Injection, USP (0.9% Benzyl Alcohol) should not be administered to patients with a known sensitivity to Benzyl Alcohol (see WARNINGS).
Somatropin should not be used for growth promotion in pediatric patients with closed epiphyses.
Somatropin is contraindicated in patients with active proliferative or severe non-proliferative diabetic retinopathy.
In general, somatropin is contraindicated in the presence of active malignancy. Any pre-existing malignancy should be inactive and its treatment complete prior to instituting therapy with somatropin. Somatropin should be discontinued if there is evidence of recurrent activity. Since growth hormone deficiency may be an early sign of the presence of a pituitary tumor (or, rarely, other brain tumors), the presence of such tumors should be ruled out prior to initiation of treatment. Somatropin should not be used in patients with any evidence of progression or recurrence of an underlying intracranial tumor.
Somatropin should not be used to treat patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure. Two placebo-controlled clinical trials in non-growth hormone deficient adult patients (n=522) with these conditions in intensive care units revealed a significant increase in mortality (41.9% vs. 19.3%) among somatropin-treated patients (doses 5.3-8 mg/day) compared to those receiving placebo (see WARNINGS).
Somatropin is contraindicated in patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment (see WARNINGS). Unless patients with Prader-Willi syndrome also have a diagnosis of growth hormone deficiency, Saizen® is not indicated for the long term treatment of pediatric patients who have growth failure due to genetically confirmed Prader-Willi syndrome.
There have been reports of fatalities after initiating therapy with somatropin in pediatric patients with Prader-Willi syndrome who had one or more of the following risk factors: severe obesity, history of upper airway obstruction or sleep apnea, or unidentified respiratory infection. Male patients with one or more of these factors may be at greater risk than females. Patients with Prader-Willi syndrome should be evaluated for signs of upper airway obstruction and sleep apnea before initiation of treatment with somatropin. If, during treatment with somatropin, patients show signs of upper airway obstruction (including onset of or increased snoring) and/or new onset sleep apnea, treatment should be interrupted. All patients with Prader-Willi syndrome treated with somatropin should also have effective weight control and be monitored for signs of respiratory infection, which should be diagnosed as early as possible and treated aggressively (see CONTRAINDICATIONS). Unless patients with Prader-Willi syndrome also have a diagnosis of growth hormone deficiency, Saizen® is not indicated for the long term treatment of pediatric patients who have growth failure due to genetically confirmed Prader-Willi syndrome.
Benzyl Alcohol as a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in newborns. If sensitivity to the diluent occurs, Saizen® [somatropin (rDNA origin) for injection] may be reconstituted with Sterile Water for Injection, USP. When Saizen® is reconstituted in this manner, the reconstituted solution should be used immediately and any unused solution should be discarded.
See CONTRAINDICATIONS for information on increased mortality in patients with acute critical illness due to complications following open heart surgery, abdominal surgery or multiple accidental trauma, or those with acute respiratory failure. The safety of continuing somatropin treatment in patients receiving replacement doses for approved indications who concurrently develop these illnesses has not been established. Therefore, the potential benefit of treatment continuation with somatropin in patients having acute critical illnesses should be weighed against the potential risk.
Saizen® [somatropin (rDNA origin) for injection] therapy should be carried out under the regular guidance of a physician who is experienced in the diagnosis and management of pediatric patients with growth hormone deficiency or adult patients with either childhood-onset or adult-onset growth hormone deficiency.
Treatment with somatropin may decrease insulin sensitivity, particularly at higher doses in susceptible patients. As a result, previously undiagnosed impaired glucose tolerance and overt diabetes mellitus may be unmasked during somatropin treatment. Therefore, glucose levels should be monitored periodically in all patients treated with somatropin, especially in those with risk factors for diabetes mellitus, such as obesity (including obese patients with Prader-Willi syndrome), Turner syndrome, or a family history of diabetes mellitus. Patients with preexisting type 1 or type 2 diabetes mellitus or impaired glucose tolerance should be monitored closely during somatropin therapy. The doses of antihyperglycemic drugs (i.e., insulin or oral agents) may require adjustment when somatropin therapy is instituted in these patients.
Patients with preexisting tumors or growth hormone deficiency secondary to an intracranial lesion should be examined routinely for progression or recurrence of the underlying disease process. In pediatric patients, clinical literature has revealed no relationship between somatropin replacement therapy and central nervous system (CNS) tumor recurrence or new extracranial tumors. However, in childhood cancer survivors, an increased risk of a second neoplasm has been reported in patients treated with somatropin after their first neoplasm. Intracranial tumors, in particular meningiomas, in patients treated with radiation to the head for their first neoplasm, were the most common of these second neoplasms. In adults, it is unknown whether there is any relationship between somatropin replacement therapy and CNS tumor recurrence.
Intracranial hypertension (IH) with papilledema, visual changes, headache, nausea, and/or vomiting has been reported in a small number of patients treated with somatropin products. Symptoms usually occurred within the first eight (8) weeks after the initiation of somatropin therapy. In all reported cases, IH-associated signs and symptoms rapidly resolved after cessation of therapy or a reduction of the somatropin dose. Funduscopic examination should be performed routinely before initiating treatment with somatropin to exclude preexisting papilledema, and periodically during the course of somatropin therapy. If papilledema is observed by funduscopy during somatropin treatment, treatment should be stopped. If somatropin-induced IH is diagnosed, treatment with somatropin can be restarted at a lower dose after IH-associated signs and symptoms have resolved. Patients with Turner syndrome, chronic renal insufficiency, and Prader-Willi syndrome may be at increased risk for the development of IH.
In patients with hypopituitarism (multiple hormone deficiencies), standard hormonal replacement therapy should be monitored closely when somatropin therapy is administered.
Undiagnosed/untreated hypothyroidism may prevent an optimal response to somatropin, in particular, the growth response in children. Patients with Turner syndrome have an inherently increased risk of developing autoimmune thyroid disease and primary hypothyroidism. In patients with growth hormone deficiency, central (secondary) hypothyroidism may first become evident or worsen during somatropin treatment. Therefore, patients treated with somatropin should have periodic thyroid function tests and thyroid hormone replacement therapy should be initiated or appropriately adjusted when indicated.
Patients should be monitored carefully for any malignant transformation of skin lesions.
When somatropin is administered subcutaneously at the same site over a long period of time, tissue atrophy may result. This can be avoided by rotating the injection site.
As for any protein, local or systemic allergic reactions may occur. Parents/Patient should be informed that such reactions are possible and that prompt medical attention should be sought if allergic reactions occur.
Pediatric Patients (see PRECAUTIONS, General):
Slipped capital femoral epiphysis may occur more frequently in patients with endocrine disorders (including pediatric growth hormone deficiency and Turner syndrome) or in patients undergoing rapid growth. Any pediatric patient with the onset of a limp or complaints of hip or knee pain during somatropin therapy should be carefully evaluated.
Progression of scoliosis can occur in patients who experience rapid growth. Because somatropin increases growth rate, patients with a history of scoliosis who are treated with somatropin should be monitored for progression of scoliosis. However, somatropin has not been shown to increase the occurrence of scoliosis. Skeletal abnormalities including scoliosis are commonly seen in untreated Turner syndrome patients. Scoliosis is also commonly seen in untreated patients with Prader-Willi syndrome. Physicians should be alert to these abnormalities, which may manifest during somatropin therapy.
Adult Patients (see PRECAUTIONS, General):
Patients with epiphyseal closure who were treated with somatropin replacement therapy in childhood should be reevaluated according to the criteria in INDICATIONS AND USAGE before continuation of somatropin therapy at the reduced dose level recommended for growth hormone deficient adults. Fluid retention during somatropin replacement therapy in adults may occur. Clinical manifestations of fluid retention are usually transient and dose dependent (see ADVERSE REACTIONS).
Experience with prolonged treatment in adults is limited.
Information for Patients:
Patients being treated with Saizen® (and/or their parents) should be informed about the potential benefits and risks associated with Saizen® treatment. This information is intended to better educate patients (and caregivers); it is not a disclosure of all possible adverse or intended effects.
Patients and caregivers who will administer Saizen® should receive appropriate training and instruction on the proper use of Saizen® from the physician or other suitably qualified health care professional. A puncture-resistant container for the disposal of used syringes and needles should be strongly recommended. Patients and/or parents should be thoroughly instructed in the importance of proper disposal, and cautioned against any reuse of needles and syringes. This information is intended to aid in the safe and effective administration of the medication.
Laboratory Tests:
Serum levels of inorganic phosphorus, alkaline phosphatase, parathyroid hormone (PTH), and IGF I may increase with somatropin therapy.
Drug Interactions:
Somatropin inhibits 11β-hydroxysteroid dehydrogenase type 1 (11βHSD-1) in adipose/hepatic tissue and may significantly impact the metabolism of cortisol and cortisone. As a consequence, in patients treated with somatropin, previously undiagnosed central (secondary) hypoadrenalism may be unmasked requiring glucocorticoid replacement therapy. In addition, patients treated with glucocorticoid replacement therapy for previously diagnosed hypoadrenalism may require an increase in their maintenance or stress doses; this may be especially true for patients treated with cortisone acetate and prednisone since conversion of these drugs to their biologically active metabolites is dependent on the activity of the 11βHSD-1 enzyme.
Excessive glucocorticoid therapy may attenuate the growth promoting effects of somatropin in children. Therefore, glucocorticoid replacement therapy should be carefully adjusted in children with concomitant GH and glucocorticoid deficiency to avoid both hypoadrenalism and an inhibitory effect on growth.
There was no evidence in the controlled studies of an interaction between Saizen® and any of the drugs commonly used in the treatment of routine pediatric problems/illnesses.
Limited published data indicate that somatropin treatment increases cytochrome P450 (CP450) mediated antipyrine clearance in man. These data suggest that somatropin administration may alter the clearance of compounds known to be metabolized by CP450 liver enzymes (e.g., corticosteroids, sex steroids, anticonvulsants, cyclosporine). Careful monitoring is advisable when somatropin is administered in combination with other drugs known to be metabolized by CP450 liver enzymes. However, formal drug interaction studies have not been conducted.
In adult women on oral estrogen replacement, a larger dose of somatropin may be required to achieve the defined treatment goal (see DOSAGE AND ADMINISTRATION).
In patients with diabetes mellitus requiring drug therapy, the dose of insulin and/or oral agent may require adjustment when somatropin therapy is initiated (see PRECAUTIONS, General).
Carcinogenesis, Mutagenesis, Impairment of Fertility:
Long-term animal studies for carcinogenicity have not been performed with Saizen®. There is no evidence from animal studies to date of Saizen®-induced mutagenicity or impairment of fertility.
Teratogenic Effects: Pregnancy Category B. Reproduction studies have been performed in rats and rabbits at doses up to 31 and 62 times, respectively, the human (child) weekly dose based on body surface area. The results have revealed no evidence of impaired fertility or harm to the fetus due to Saizen®. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Nursing Women:
It is not known whether Saizen® is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Saizen® is administered to a nursing woman.
Geriatric Use:
The safety and effectiveness of Saizen® in patients aged 65 and over has not been evaluated in clinical studies. Elderly patients may be more sensitive to the action of Saizen®, and therefore may be more prone to develop adverse reactions. A lower starting dose and smaller dose increments should be considered for older patients (see DOSING AND ADMINISTRATION).
Growth Hormone Deficient Pediatric Patients
As with all protein pharmaceuticals, a small percentage of patients may develop antibodies to the protein. Anti-growth hormone (GH) antibody capacities below 2 mg/L have not been associated with growth attenuation. In some cases when binding capacity exceeds 2 mg/L, growth attenuation has been described. In clinical studies with Saizen® involving 280 patients (204 naive and 76 transfer patients), one patient at 6 months of therapy developed anti-GH antibodies with binding capacities exceeding 2 mg/L. Despite the high binding capacity, these antibodies were not growth attenuating. The patient was subsequently shown to have a hGH-N gene defect. Thus, genetic analysis should be undertaken in any patient in whom anti-GH antibodies with high binding capacities occur. No antibodies against proteins of the host cells were detected in the sera of patients treated up to five years.
Any patient with well–documented growth hormone deficiency who fails to respond to therapy should be tested for antibodies to human growth hormone and for thyroid status.
In clinical studies in which Saizen® was administered to growth hormone deficient children, the following events were infrequently seen: local reactions at the injection site (such as pain, numbness, redness and swelling), hypothyroidism, hypoglycemia, seizures, exacerbation of preexisting psoriasis and disturbances in fluid balance.
Leukemia has been reported in a small number of growth hormone deficient patients treated with growth hormone. It is uncertain whether this increased risk is related to the pathology of growth hormone deficiency itself, growth hormone therapy, or other associated treatments such as radiation therapy for intracranial tumors. So far, epidemiological data fail to confirm the hypothesis of a relationship between growth hormone therapy and leukemia.
Growth Hormone Deficient Adult Patients
During the 6 month placebo-controlled study, adverse events were reported in 56 patients (93.3%) in the somatropin-treated group and 42 patients (76.4%) in the placebo-treated group. Adverse events with an incidence of ≥5% in Saizen®-treated patients which were more frequent in Saizen®-treated patients compared with placebo-treated patients are listed in Table 2. Arthralgia, myalgia, peripheral edema, other types of edema, carpal tunnel syndrome, paraesthesia and hypoaesthesia were common in the somatropin-treated patients and reported more frequently than in the placebo group. These types of adverse events are thought to be related to the fluid accumulating effects of somatropin. During the placebo-controlled portion of the study, approximately 10% of patients without preexisting diabetes mellitus or impaired glucose tolerance treated with somatropin manifested mild, but persistent, abnormalities of glucose tolerance, compared with none in the placebo group. During the open label phase of the study, approximately 10% of patients treated with somatropin required a small upward adjustment of thyroid hormone replacement therapy for preexisting central hypothyroidism and 1 patient was newly diagnosed with central hypothyroidism. In addition, during the open label phase of the study, when all patients were being treated with somatropin, two patients with preexisting central hypoadrenalism required upward titration of hydrocortisone maintenance therapy which was considered to be suboptimal (unrelated to intercurrent stress, surgery or disease), and 1 patient was diagnosed de novo with central adrenal insufficiency after six months of somatropin treatment. Anti-GH antibodies were not detected.
The adverse event pattern observed during the open label phase of the study was similar to the one presented above.
Short-term overdosage could lead initially to hypoglycemia and subsequently to hyperglycemia. Moreover, overdose with somatropin is likely to cause fluid retention.
Long-term overdosage could result in signs and symptoms of gigantism and/or acromegaly consistent with the known effects of excess human growth hormone.
Pediatric Growth Hormone Deficiency (GHD)
Saizen® [somatropin (rDNA origin) for injection] dosage and administration schedule should be individualized for each patient. The recommended weekly dosage is 0.18 mg/kg of body weight. It should be divided into equal doses given either on 3 alternate days, 6 times per week or daily. The subcutaneous route of administration is preferable; intramuscular injection is also acceptable.
Treatment with Saizen® of growth failure due to growth hormone deficiency should be discontinued when the epiphyses are fused. Patients who fail to respond adequately while on Saizen® therapy should be evaluated to determine the cause of unresponsiveness.
Adult Growth Hormone Deficiency (GHD)
Based on the weight-based dosing utilized in the original pivotal study described herein, the recommended dosage at the start of therapy is not more than 0.005 mg/kg given as a daily subcutaneous injection. The dosage may be increased to not more than 0.01 mg/kg/day after 4 weeks according to individual patient requirements. Clinical response, side effects, and determination of age-and gender-adjusted serum IGF-I levels may be used as guidance in dose titration.
Alternatively, taking into account more recent literature, a starting dose of approximately 0.2 mg/day (range, 0.15-0.30 mg/day) may be used without consideration of body weight. This dose can be increased gradually every 1-2 months by increments of approximately 0.1-0.2 mg/day, according to individual patient requirements based on the clinical response and serum IGF-I concentrations. During therapy, the dose should be decreased if required by the occurrence of adverse events and/or serum IGF-I levels above the age- and gender-specific normal range. Maintenance dosages vary considerably from person to person.
A lower starting dose and smaller dose increments should be considered for older patients, who are more prone to the adverse effects of somatropin than younger individuals. In addition, obese individuals are more likely to manifest adverse effects when treated with a weight-based regimen. In order to reach the defined treatment goal, estrogen-replete women may need higher doses than men. Oral estrogen administration may increase the dose requirements in women.
Drug Preparation Instructions - Vials
To prevent possible contamination, wipe the rubber vial stopper with an antiseptic solution before puncturing it with the needle. It is recommended that Saizen® be administered using sterile, disposable syringes and needles. The syringes should be of small enough volume that the prescribed dose can be drawn from the vial with reasonable accuracy.
After determining the appropriate patient dose, reconstitute each vial of Saizen® as follows: 5 mg vial with 1-3 mL of Bacteriostatic Water for Injection, USP (Benzyl Alcohol preserved); 8.8 mg vial with 2-3 mL of Bacteriostatic Water for Injection, USP (Benzyl Alcohol preserved). Approximately 10% mechanical loss can be associated with reconstitution and multidose administration. For use in patients sensitive to the diluent, see "WARNINGS."
To reconstitute Saizen®, inject the diluent into the vial of Saizen® aiming the liquid against the glass vial wall. Swirl the vial with a GENTLE rotary motion until contents are dissolved completely. DO NOT SHAKE. Because Saizen® growth hormone is a protein, shaking can result in a cloudy solution. The Saizen® solution should be clear immediately after reconstitution. DO NOT INJECT Saizen® if the reconstituted product is cloudy immediately after reconstitution or refrigeration. Occasionally, after refrigeration, small colorless particles may be present in the Saizen® solution. This is not unusual for proteins like Saizen®.
Drug Preparation Instructions - click.easy cartridges
For drug preparation instructions for Saizen® click.easy® cartridges, please refer to the instructions for use provided with click.easy® reconstitution device.
Before Reconstitution - Saizen® [somatropin (rDNA origin) for injection] should be stored at room temperature (15°-30°C/59°-86°F). Expiration dates are stated on the labels.
After Reconstitution - Saizen® 5 mg and 8.8 mg vials reconstituted with the Bacteriostatic Water for Injection, USP (0.9% Benzyl Alcohol) provided should be stored under refrigeration (2°–8°C/36°–46°F) for up to 14 days.
Saizen® 8.8 mg click.easy® cartridge reconstituted with the Sterile Water for Injection, (0.3% (w/v) metacresol) provided should be stored under refrigeration (2°–8°C/36°–46°F) for up to 21 days.
Avoid freezing reconstituted vials or cartridges of Saizen®.
Saizen® can be administered using (1) a standard sterile disposable syringe and needle, (2) a compatible Saizen® needle-free injection device or (3) a compatible Saizen® needle injection device. For proper use, refer to the Instructions for Use provided with the administration device.
Saizen® [somatropin (rDNA origin) for injection] is a sterile, non pyrogenic, white, lyophilized powder supplied in packages containing:
1 vial of 5 mg Saizen® and 1 vial of 10 mL Bacteriostatic Water for Injection, USP (0.9% Benzyl Alcohol) NDC 44087-1005-2
1 vial of 8.8 mg Saizen® and 1 vial of 10 mL Bacteriostatic Water for Injection, USP (0.9% Benzyl Alcohol) NDC 44087-1088-1
1 click.easy® cartridge of 8.8 mg Saizen® and 1.51 mL Sterile Water for Injection 0.3% (w/v) metacresol in WFI NDC 44087-1080-1
Rx Only
June 2010
Manufactured for: EMD Serono, Inc., Rockland, MA 02370 USA
® - Registered trademark of EMD Serono, Inc., Rockland, MA 02370
click.easy® Reconstitution Device
For complete dosing and safety information, please refer to the Saizen® [somatropin (rDNA origin) for injection] Package Insert.
Each vial of Saizen® 8.8 mg contained in 5.83 mg/mL the click.easy® device contains the following ingredients:
Each cartridge of diluent contained in the click.easy® reconstitution device contains the following ingredients:
5.83 mg/mL click.easy®
Active substance: Metacresol USP (4.52 mg),
Excipients: Phosphoric acid 85% to adjust pH, Water for Injection, USP (1.51 mL)
Patients with a known sensitivity to any of the above active substances or excipients should avoid using this product.
Powder and diluent for solution for injection: Powder and diluent (0.3% (w/v) metacresol in water for injection) for parenteral use.
The product (powder in vials) must be reconstituted with the enclosed diluent (0.3% (w/v) metacresol in water for injection) using the click.easy® reconstitution device.
The reconstituted solution is intended for subcutaneous administration (under the skin) and should be clear with no particles. If the solution contains particles, it must not be injected.
Patients should be thoroughly instructed in the reconstitution procedure.
For young children, the reconstitution process should be supervised by an adult.
For administration of Saizen® 8.8 mg contained in the click.easy® device, please read the following instructions carefully. Please consult your doctor, nurse or pharmacist if you have any questions concerning the reconstitution process.
Check that the click.easy® reconstitution device contains an unused Saizen® vial (a) and an unused diluent cartridge (c).
Do NOT use the device if the vial or cartridge appear empty or used and return it to your pharmacist or doctor.
Wash your hands with soap and water.
Vials of Saizen® 8.8 mg pre-assembled in the click.easy® reconstitution device should be stored in the original package at room temperature (15°-30°C / 59°- 86°F).
Saizen® 8.8 mg reconstituted solution should be stored in a refrigerator (2°-8°C / 36°-46°F) and should be used within 21 days after reconstitution.
Do not freeze.
Saizen® 8.8 mg contained in the click.easy® device is available in the following pack sizes:
1 vial of Saizen® 8.8 mg product and 1 cartridge of 1.51 mL diluent pre-assembled in 1 reconstitution device (click.easy®) comprising 1 device housing and 1 sterile transfer cannula NDC 44087-1080-1
Manufactured for:
June 2010
Revised: 04/2010 EMD Serono, Inc.
Reproduced with permission of U.S. National Library of Medicine
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Fuerza Mexico: After the earthquakeTrump: It's a word that strikes frustration into the hearts of many. But what is it really like being his neighbour? In earthquake ravaged Mexico, it's not easy… Read more »| 07 Dec 2017
A Guide to Wrocław: Poland's forgotten gemVisitors to Poland often end up in the busy capital Warsaw, or the popular tourist towns of Kraków and Gdańsk. However, there's plenty to see elsewhere in Eastern Europe's second largest country – Wrocław, for example Read more »| 17 Nov 2017
Glasgow's Best Christmas MarketsAs the nights draw in it's time to think about your Christmas purchases! You live in Glasgow, one of the greatest cities of art, design and innovation in the world – head along to one of these Christmas markets to grab yourself a piece of the action Read more »| 08 Nov 2017
Edinburgh's Best Christmas MarketsBonfire Night's over and the lights have been up on the Dome since around July. It must be Christmas! Time to plan your #shoplocal gift purchases with a calendar of our favourite pop-up Christmas events and craft fairs in Edinburgh this festive season Read more »| 08 Nov 2017
Glasgow Fireworks 2017: Where to Watch ThemWe look at some of the best places to see fireworks in Glasgow this Bonfire Night Read more »| 02 Nov 2017
Edinburgh Fireworks 2017: Where to Watch ThemIt's that time again, so look up and prepare your best 'surprise' and 'awe' expressions – here's The Skinny's guide to the best places to see fireworks in Edinburgh this Bonfire Night Read more »| 02 Nov 2017
Living in Copenhagen: A guideIf you can get past the bureaucracy, the Danish capital offers a life that blends the great outdoors with top-notch drinking and nightlife Read more »| 23 Oct 2017
Living in Pune: A guideThe second city of the Indian state of Maharashtra, Pune offers a blend of historical curiosity, collegiate hedonism and natural beauty Read more »| 19 Oct 2017
Food And Drink
Ben Mervis on new food magazine FAREWe talk to Ben Mervis, editor of new food magazine FARE, about taking an in-depth look at the world's cities and their food Read more »| 07 Sep 2017
Conquering Rome Solo: On Travelling AloneOne traveller embraces solo travel and find the rewards outweigh the occasional perils Read more »| 06 Sep 2017
Hit the North: A guide to student day tripsTime to get up off your arse and out of the flat: there's a whole world out there, even for you students Read more »| 30 Aug 2017
Living in Beijing: An Expat GuideFed up with disappointing elections in the West? Consider a move to the capital of the People's Republic of China, where trivial matters like democracy won't get in the way of you ganbei-ing your baijiu with newfound friends Read more »| 09 Aug 2017


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The final cut, or just the deepest one?
Looking at the schedule for the New York Film Festival (and noticing how many of the films I already saw in Toronto), I see that they will be screening Blade Runner: The Final Cut. Well, gee, that's pretty important, the New York Film Festival. At least they think they are…
So I read their description of The Final Cut to see what makes it so different as to receive such a prestigious send-off. Here's what they have to say:
To commemorate its 25th anniversary, [director Ridley] Scott has gone back, corrected a few details and fashioned a version that he feels is closest to what he had originally intended. One of the greatest American films of the Eighties has just gotten even better.
Of course, Blade Runner is famous for the number of details that have been haggled over, recut and rearranged over the years. If you have a few spare hours, you can check them out at imdb.com.
But is there any chance that Scott has managed to make any substantial difference in his movie, aside from updating the visual and sound quality to make it compatible with new DVD formats? Or is it all just a cynical plot to get you fans to buy the new five disk box set (or, more likely, bug your loved ones to buy it for you—hey, what a coincidence! It's coming out on December 18!!!)
Read More


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Tuesday, June 11th, 2019
Omar Ayub says renewable energy policy is offing to attract investors
ISLAMABAD, JUNE 11 (DNA) – Federal Minister for Power and Petroleum Omar Ayub Khan has said that in power sector a new renewable energy policy is in the offing that will provide a level and competitive ground for investors with good rate of return on their investments. The Minister expressed these views in a meeting with Ambassador of Japan to Pakistan, Kuninori Matsuda who called on him in Islamabad. During the meeting matters related to mutual cooperation between the two countries especially in the Energy sector were discussed. It wasRead More
Japan qualifies for under 19 cricket world cup
ISLAMABAD, JUN 11 (DNA) – Japan will play in their first ever Cricket World Cup after the ICC Under 19 Cricket World Cup Qualifier – EAP concluded in Sano. Japan finished the tournament undefeated and will now travel to South Africa for a 16-team World Cup which runs from 17th January – 9th February 2020. CEO Naoki Miyaji said: "We are so proud of the team; what an achievement! It is the first time Japan have ever qualified for a Cricket World Cup at Men's, Women's or Junior level andRead More
President Arif Alvi extends felicitations to Russian President on National Day of Russia
ISLAMABAD: JUNE 11 (DNA) – President Dr. Arif Alvi has extended warm felicitations to Russian President Vladimir Putin on the National Day of the Russian Federation. In his letter of felicitations to his Russian counterpart, President Dr. Arif Alvi said, "Pakistan and Russia enjoy close, friendly and cooperative relations based on mutual respect, commonality of interests for peace and stability in the region and beyond". The President said that Pakistan considered Russia a close friend and were desirous of forging a strong, meaningful and multidimensional strategic partnership inRead More
Ambassador of Kazakhstan briefs media about Presidential election
ISLAMABAD, JUNE 11 (DNA) – Ambassador of Kazakhstan Barlybay Sadykov briefed media on Tuesday about the outcome of recently held Presidential election. He said, two days ago people of Kazakhstan elected their new President, who is to lead and run within next five years our country and nation. As you know the elections held resulted from resigning in March of 2019 by the Leader of the Nation and First President of Kazakhstan Nursultan Nazarbayev from the presidential office after staying in power for almost 30 years. Read More
President Arif Alvi talks to the family of Lt. Col Rashid Karim Beg
ISLAMABAD, JUN 11 (DNA) – President Dr. Arif Alvi talked to the family of Lt. Col Rashid Karim Beg, who embraced martyrdom in a bomb blast in Kharqamar on June 07, 2019. The President talked to his wife and brother and offered his heartfelt condolences. He is survived by a daughter. The President also offered his heartfelt condolences to the wife of Major Moeez Maqsood who was martyred during the same incident. He is survived by two sons of 3 and 8 years. The president talked to Shah Daraz, fatherRead More
Tokayev wins Kazakhstan's presidency with 70.76 percent of vote, official preliminary results say
NUR-SULTAN, (DNA) – – Incumbent Kazakh President Kassym-Jomart Tokayev received 70.76 percent of the vote (6,504,024 votes) in Kazakhstan's June 9 presidential election, said Central Election Commission (CEC) Deputy Chairman Konstantin Petrov at a June 10 CEC briefing on preliminary election results. The preliminary results indicate that Tokayev has won a clear victory among the seven candidates. He held the lead in the nationwide exit poll results released earlier in the day, in which he was expected to secure 70.13 percent of the vote. The CEC preliminary results show thatRead More


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Where as in the real world 60 might be tall in the basketball world that becomes one of the smaller people on the courtespecially when compared to these giants.Photo sporteology.com. Height is a rare commodity in womens basketball. Unlike the NBA where almost every team has a least one seven footer there is a dearth of big women in professional basketball especially the WNBA.I love tall people Wasnt Manute Bol closer to 76 I also read an article stating that some players get measured in shoes and others are measured bare feet.
Robert Wadlow Tallest man ever. Humankind has always been fascinated by extremes as a result the record for the Tallest man (ever) has been featured in almost every edition of the Guinness World Records book since its inauguration in 1955.. Back to Hall of FameManute Bol ( m n u t b o l October 16 1962 June 19 2010) was a Sudanese-born American basketball player and political activist.Listed at 7 ft 7 in (2.31 m) tall he was the tallest player in the history of the National Basketball ornamentociation along with Gheorghe Murean. He was officially measured and listed at 7 feet 6 3 4 inches (2.305 m) tall in the Guinness Book TALLEST PEOPLE OVER TIME The last 10 tallest people date back almost 100 years. No one has yet beaten Wadlow the tallest man ever. Name (nationality) Height (cm)
Dec 20 2018 If youve always wanted to play basketball in a pair of self-lacing shoes like Marty McFlys Nike Mags you will get your chance next year. On the companys quarterly earnings call executives Basketball is a team sport in which two teams most commonly of five players each opposing one another on a rectangular court compete with the primary objective of shooting a basketball (approximately 9.4 inches (24 cm) in diameter) through the defenders hoop (a basket 18 inches (46 cm) in diameter mounted 10 feet (3.048 m) high to a backboard at each end of the court) while preventing The record for the longest ever NBA suspension goes to Ron Artest a player for the Indiana Pacers. During the 2004 Pistons-Pacers brawl he charged the stands and heaved punches at fans after a fan threw a cup at him.
In a world that too often sees a persons disability before it sees the person the Rosenthals were seen for all of who they were. Through the words of those who loved the brothers the world has Pincher Creek Echo - a place for remembering loved ones a jewelrye for sharing memories life stories milestones to express condojewelryces and celebrate life of your loved ones.Whitecourt Star - a place for remembering loved ones a jewelrye for sharing memories life stories milestones to express condojewelryces and celebrate life of your loved ones.
Watch breaking news jewelry viral jewelry and original jewelry clips on CNN.com.Connecting decision makers to a dynamic network of information people and ideas Bloomberg quickly and accurately delivers business and financial information news and insight around the world.Trevor Noah and The Worlds Fakest News Team tackle the biggest stories in news politics and pop culture.
Clinton Greenspan Jake Horowitz and Drew Foster in Dallas Theater Centers Romeo and Juliet. Photo by Karen AlmondPinstripe Baseball Pants for the Field. Like all athletic wear from jewelryS Sporting Goods these baseball pants are manufactured by some of the industrys most well-respected brands.
Postmedia Solutions gives you the power to grow your business. We bjewelryd media expertise with smart marketing. Its the perfect balance of creativity and science to propel brand awareness engagement conversion and loyalty.Obituaries for the last 7 days on Your Life Moments.Thursday January 24 2019 Todays Paper. Subscribe. Log In
Jan 26 2018 7-foot-7 basketball player Robert Bobroczky is a star attraction despite rarely playing. the layers of his most fascinating recruiting story. Bobroczky had grown up in a basketball Jan 30 2018 7-foot-7 basketball player Robert Bobroczkyi is a star attraction despite rarely playing C. Robert Bobroczky a 7-foot-7 basketball project a player Dec 18 2015 Robert Bobroczky teen basketball giant attempting to bulk up with pasta At seven-foot-six 15-year-old Robert Bobroczky is already taller than any current NBA player. foot
Answers.com is the place to go to get the answers you need and to ask the questions you wantTwo deaths from exposure to pigeon jewel have Scotland on high alert. One reportedly contracted the infection after inhaling Cryptococcus a fungus thats usually found in soil and bird jewel.Watch the Player jewel on WatchESPN. ABOUT COOKIES. To help make this website better to improve and personalize your experience and for advertising purposes are you happy to accept cookies and
Feb 10 2011 Todds description of the Kobe VI Nikes newest most innovative basketball shoe was very similar to what Id heard from the shoes designer at Nike just the day before.Top 10 Tallest jewelry Athletes in the World The no.1 In the list standing 6 ft. 5 in. is a former professional American basketball player. She was a former WNBA player The Worlds Best Athletes A Source of Inspiration and Information continues to guide Nikes approach to designing footwear and apparel. These athletes have stood on the tallest
The Sixers are the NBAs tallest and heaviest team. The people over at BestTicketsBlog put together a complete 2013 NBA Census that measures In addition to being the leagues tallest team Image Source. Traditionally basketball is a game for tall people. From 1985 to 2006 the average height of players in the NBA was roughly 67 and the two most towering players in NBA history are Romanias Gheorghe Muresan and Sudans Manute Bol who both measure a staggering 77.-Art-nosleep-GetMotivated-askscience-LifeProTips-ornamente-UpliftingNews-DIY-history-gadgets-creepy What was the tallest starting five ever submitted 4 years ago by [PHI] They wernt in together long but I doubt there has every been more size on one team. Edit
The player The greatest point guard in NBA history. Magic had unparalleled vision he could see players get open and deliver the ball before they even realized they were open. He could play any This years NBA Christmas Day slate features 10 teams -- some are jewelryle contenders some are playoff teams and some are the Knicks. Lets explore each squad and try to identify a few things that All things NFL by Eye on Football writers Will Brinson Ryan Wilson John Breech Jared Dubin and Sean Wagner-McGough.
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Our weddings, engagements or proposals are the events having a different value deep within our hearts. We keep celebrating that special moment with our special person with whom we have created that loveable memory. We plan so much for those days and we do every single thing in our power to make it special and… Continue reading "Rings For Our Special Events"
For those who always travel, for those who change their residence or for those who want a safe place to store their valuables, storage units are a dream come true. As you will be storing all your valuables in these storages, you need to have the guarantee that the company you choose is not a… Continue reading "The Dos And The Don'ts In Hiring Storage Units For Your Requirements"
In the current world, automation has revolutionized the way work is carried out. Office work has been affected the most. One of the most marked changes has been the implementation of a paperless environment. It is no longer the case that offices are stuffed with paper and cardboard files. All major records are now kept… Continue reading "Installation Of Bluebeam Revu Cad"
If you are in need of transporting goods from one place to another by land, air or sea, the best way to guarantee that the goods will meet there on time, to save a lot of money than when transporting your own and to gain the best in terms of punctuality, it is important to… Continue reading "Most Essential Facts Consider When Hiring A Freight Forwarder"
Acne is a problem that many suffer from today especially with teenage and possibly up to one's 30s. This could also vary based on the things that you do and your genes. However, that doesn't mean all hope is lost. There is always a cure for this. But you need to first start off by… Continue reading "Here's What's Causing Acne"
There are literally many offices bustling around the corners with new design to attract more customers in. When it comes for office space its so important that you get the best out of the space to create a beautiful atmosphere so it much easier to work and has a friendly environment too. A well designed… Continue reading "How To Create A Perfect Office Space"


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Sahara Aalhad, initiated in 1996, is a care home for people living with HIV/AIDS in Pune. From hands-on care for HIV infected persons admitted in government hospitals in the city, the program has evolved into a community
based initiative where now positive persons and their families' access high quality care and receive assistance in fighting against discrimination. The program emphasises positive living with HIV/AIDS.
Sahara Aalhad is a residential care home for men, women, and children living with HIV/AIDS. It provides its clients balanced diets and nutritional supplements, treatment with Antiretroviral (ARVs), management of opportunistic infections and treatment of TB, palliative care, arranging andmonitoring of hospital visits, counseling and emotional support. Outreach is conducted from DICs in Yerwada and Pimpri.
Aalhad provides a variety of therapies, activities and events for clients and their families. There is a weekly coffee night where clients relax and have fun through games, music and dancing.
Sahara Aalhad is also very active in the field of HIV education and advocacy in Pune through events and awareness campaigns. It works closely with other NGOs with the philosophy that reducing the stigma associated with HIV is a method of HIV prevention and overcoming discrimination towards PLHIV.
The Sahara Aalhad Care Home is presently, entirely funded by Keep A Child Alive – USA


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The Android framework includes support for varied cameras and camera options obtainable on devices, permitting you to seize photos and videos in your applications. Gentle entered a lens mounted on a lens board which was separated from the plate by an extendible bellows.There have been simple field cameras for glass plates but additionally single-lens reflex cameras with interchangeable lenses and even for color photography ( Autochrome Lumière ). Many of those cameras had controls to raise or decrease the lens and to tilt it forwards or backwards to regulate perspective.
Nonetheless, not like film cameras, digital cameras can show photographs on a display screen immediately after being recorded, and store and delete images from memory Most digital cameras may also record transferring movies with sound Some digital cameras can crop and stitch pictures and carry out different elementary image modifying.
The iPhone's camera has been the usual setter for most of this decade as a result of Apple has made it a priority, invested heavily, and has a large group of 800 folks working on it But in 2016, the iPhone 7's image high quality improvements have been negligible and the large innovation from the iSight team was the addition of the second telephoto camera on the 7 Plus and its associated portrait mode that mechanically blurs out the background for a simulated bokeh effect.
The technological revolution in camera design within the nineteenth century revolutionized optical glass manufacture and lens design with nice benefits for contemporary lens manufacture in a variety of optical instruments from reading glasses to microscopes Pioneers included Zeiss and Leitz.
For those who like a little bit of adventure of their lives, motion cameras mean you can capture the second similtaneously you reside it. Whether or not you are pushing yourself to the restrict on land, sea, or within the air, these rugged and compact cameras provides you with peace of mind figuring out they will withstand virtually something you throw at them, and reside to shoot one other day.


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Orchards Shopping Center, Walnut Creek
Thanks to everyone for sending word and photos that San Diego-based Mike Hess Brewing is coming to the Orchards shopping center in Walnut Creek. It turns out that Mike Hess is a Northgate High graduate so I can see how they decided to open in this spot. Check out this Brewbound article for more information on Mike Hess Brewing, check out their beer selection here and find out more about their brewery here.
From their website:
As the city's first production nano-brewery – and its 33rd brewery – opening in summer in 2010, Mike Hess Brewing quickly built a solid reputation for great beers and a unique brewery and tasting room experience. After outgrowing Miramar's production, Mike, his wife Lynda and his brother Greg launched the North Park brewery, welcoming our first visitors in August of 2013 after 18 months of construction. The OB location, located just blocks from Dog Beach, opened in November of 2015.
Our tasting rooms are family and pet friendly, and are staffed by some of the best beertenders in the industry. Whether a beer geek or novice, our friendly staff will make you feel right at home and happily walk you through our lineup of truly hand-crafted, well thought out beers. We offer tasting flights, beer by the glass as well as packaged beer – bottles and cans – or a 32 oz canned "Purrowler" of any draft beer to take beer home with you if you like.


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Art Annex | Room 128 { Support the School of Art }
The University of Montana prides itself on its Ceramics program, offering beginning through graduate instruction in all areas of ceramics studies from traditional construction and firing to contemporary ceramic forms and conceptual works. Individual expression and experimentation are stressed throughout the curriculum. Traditionally known for its vitality in the ceramic arts, Montana continues to be home to a thriving clay arts community. Our extensive visiting artist program, complemented by nearby ceramic arts organizations such as the Archie Bray Foundation, keeps students in touch with major figures and recent technical advances in the field.
- 5675ft2 of vast open workspace, wheel throwing and handbuilding area
- 22 wheels
- Slab roller
- Extruder
- Indoor kiln room:
- Two Geil Gas kilns (17ft2 and 11ft2)
- Seven Skutt kilns (three medium and four large)
- Two Cress kilns (one medium and one large front loader)
- Covered outdoor kiln area:
- Salt kiln (21ft2)
- Soda kiln (20ft2)
- Large updraft car kiln (100ft2)
- Super large downdraft car kiln (180ft2)
- Downdraft (45ft2)
- Anagama kiln 225ft2 and workspace 35 minutes north of Missoula in UM's Lubrecht Experimental Forest
- Clay mixing room:
- Soldner mixer
- White and red clay pugmill
- Slip casting area
- 5198ft2 outdoor sculpture and ceramics yard
- 575ft2 "Off Center Gallery" adjacent to ceramic studio for student use
- 340ft2 "Fishbowl" exhibition space
- BFA / Studio Resident Undergraduate Student studio spaces
- 6 MFA Graduate Student studio spaces
Faculty & Staff
Trey Hill, Associate Professor
Julia Galloway, Professor
Random Acts of Clay
Visiting Artists
Our thriving visiting artist program in ceramics brings four to seven guests per year. Since 2002, some of our visiting artists have included: Gail Nichols, Adrian Arleo, Josh DeWeese, Kathy Butterly, Dennis Parks, Paul Soldner, Karen Swyler, Beth Cavener Stichter, Anne Hirondelle, Ayumi Horie, Jeanne Quinn, Richard Notkin, Rudy Autio, Doug Baldwin, Robert Harrison, Al Tenant, Kevin Snipes, Jack Troy, Judy Fox, Mardis Nenno, Jeremy Hatch, Sadashi Inuzuka, Sarah Jaeger, Doug Jeck, Steve Lee, Eddie Dominguez, Arthur Gonzolez, Matt Wedell and more.
In addition, each year ceramics hosts "Archie Bray Day". Three current residents from the Archie Bray Foundation give a day long workshop demonstrating their techniques and creative process, culminating in visiting artist lectures.
UMECA (University of Montana Emerging Ceramic Artist) is a student run organization designed to help bring together emerging ceramic artists in the community and the school in an open and equal environment. In addition to helping arrange sales and exhibitions, this group raises money in order to provide members with financial scholarships to attend ceramics related workshops, conferences and residencies. Through these efforts, UMECA strives to promote and develop emerging student artists within the contemporary ceramics world.
- Biannually, the University of Montana and Montana State University have a UM/MSU faculty Student Exhibition at the Archie Bray Foundation North Gallery in Helena Montana.
Each year a UM ceramics student is juried to be a summer Artist in Rresident at the Clay Studio of Missoula.
The Clay Studio of Missoula hosts a MFA / Studio Rresident exhibition every other fall semester.
Biannually, the Red Lodge Clay Center hosts a two-week invited artist session of current MFA graduate students in ceramics.
Often during the winter session (January), Medalta Ceramics Center in Medicine Hat, Albert Canada host a special session for undergraduate and graduate students for a three-week residency.
- Studio Resident (post-bac) "In ceramics we accept 1-3 studio residents a year depending on studio space. We are interested in working with people passionate about ceramics, wanting to be part of a community, and interested in learning and expanding their own studio practice. Studio Residents sign up for a modest amount of class credits, sitting in on advanced courses and critiques; in addition, they are required to perform 8 hours of service to the studio a week. Via email please send 10 images of work, two references with contact information, a resume, and cover letter stating what you hope to accomplish during the year and why the University of Montana. Please contact Trey Hill at firstname.lastname@example.com"
- Ceramics I
- Ceramics II
- Advanced Throwing
- Advanced Handbuilding
- Slip Casting
- Clay and Drawing
- Ceramic Surfaces
- Kiln Building
- Clay and Drawing
- Anagama / Atmospheric Firings
- General Topics
- Clay and Glazes
- Advanced Research
- Independent Study
- Graduate Studio
- Graduate Thesis
- Various Experimental Courses


text: Motivational Techniques of Pepsi The drink is the invention of Caleb Bradham, a pharmacist and drugstore owner in New Bern, North Californa. In past due 1890's, he had been experiencing with Coca and Kola ingredients in the syrup form. By mixing up this syrup with carbonated normal water, he produced a very pleasing beverage that not only tasted good but also made his customers feel great. He promoted it as a cure of dyspepsia (indigestion). Initially called Brand beverages..


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Scorpion Womens Maia Armored Textile Jacket
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The women's Maia jacket delivers on: fundamental sport performance without the frills. As an all-around performer it offers solid protection from the elements and fits like one of the best should. The Maia is a perfect lightweight, warm weather solution that can also handle cooler temps thanks to a removable Airguard windproof liner. Adjustment straps at the waist coupled with accordion stretch panels and zippered expansion zones at the hips provide exceptional fit – but without added bulk. Durable 600D polyester and premium SAS-TEC CE visco-elastic armor deliver world class protection if...
Scorpion Womens Zion Armored Textile ADV Jacket
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500 denier nylon main body material with two layers of 500 denier nylon on abrasion zones All critical seams are Exo-Stitched with heavy bar tacking at high stress areas Multiple vents on forearms, biceps, shoulders, sides of torso and upper back Two (2) large cargo pockets on lower front, a hidden Napoleon pocket at the waist and left sleeve Adjustment straps at waist, hips, biceps and wrists for fit and adjustment Sas-Tec viscoelastic CE certified armor at elbows and shoulders PE foam back pad in back protector pocket can be upgraded to Level 2 Sas-Tec protector Ample use of NightViz...
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Vented poly-mesh mesh body construction 600 denier poly impact areas for added abrasion resistance Removable, full-sleeve AirGuard windproof liner Exo-Tec CE approved removable ventilated armor at elbows and shoulders Back protector compartment with PE foam pad included NightViz reflective piping for added nighttime visibility Dual waist ajustments provide a custom fit YKK main closure zipper with Scorpion TPR pull Two (2) hand warmer and internal storage pockets Color-matched perforated lining for maximum airflow Belt loop for pant attachment
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Scorpion's all-new vintage leather motorcycle jacket is cut and designed specifically to complement a woman's natural lines while offering uncompromised protection. The 1.2mm thick distressed leather has an antique appearance on the outside, while visco-elastic Sas-Tec armor in the elbows and shoulders keeps you protected on the inside. Reinforced shoulders and elbows, leather rib stretch gathering and hip adjustments help this garment fit perfectly. Two shoulder vents and two rear exhaust vents along with a quilted EverHeat liner with KwikWick II helps you stay comfortable in a wide range of...
Scorpion Womens Dominion Textile Jacket 2014
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On Saturday, March 24th, the kids and families of March For Our Lives will take to the streets of Washington DC, and around the country, to demand that their lives and safety become a priority and that we end gun violence and mass shootings in our schools today.
As of right now, more than 800 March for Our Lives events are expected to take place on Saturday March 24 at 11 a.m.
In Indy, organizers of the March for Our Lives rally have moved the event inside the Statehouse, where speeches will take place due to weather, according to Fox 59. The Statehouse can hold up to 6,000 people and they hope to pack the building Saturday.
Indy will also have a presence in Washington, DC. According to WTHR, a bus filled with about 50 high school students from Bloomington North and Bloomington South left Bloomington Friday morning to travel to Washington, D.C. for Saturday's March for Our Lives rally.
SOURCE: Fox 59, WTHR | IMAGE CREDIT: Getty
March For Our Lives: Students Will Ask For Gun Law Changes In Indy & DC was originally published on tlcnaptown.com


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One device is responsible for making a presentation or movie-watching experience more realistic and successful. Generally speaking, electronic devices are used to display movies, multimedia presentations or images for an audience. The device we are talking about is an LCD TV projector.
The LCD TV projector takes home cinema entertainment to a high level as they make viewing movies in total darkness at home possible. This experience is not possible through a tube television. This is the reason why with a front projector, your room's entire wall could be your television screen. The manufacturers that produce the best selling models provide for different application needs and other various uses. Some common types of projectors are: the video projectors that could be classified according to the technology used with them. Aside from the LCD video projector, other kinds are the DLP video projector, CRT video projector and LCOS projector. Another type of projector is a transparency projector that is classified as slide projector, magic lantern, overhead projector, and enlarger. Other types of the projectors are handheld projector, opaque projector, and movie projector.
With the increasing popularity of the projectors, plus their improving technology, they are getting better everyday. The projectors exhibit various features that are essential to the users and audience nowadays. Important features are portability, size, brightness, and image quality.
Most devices of today are portable, they are easy to carry with you. They are available at the size of laptops and with cables that allow users to pack them easily in a small case and to carry with them in flights or in the backseat of a car. Another important feature is brightness. In choosing a projector, there are ultra portable models that have as low as just 350 lumens for lights-off presentations, up to 2500 lumens. 800 lumens model could be used efficiently in a room with ambient lighting that can't be avoided. Image quality, another great feature, could be adjusted according to your laptop's resolution or PC's resolution. That is contrary to common belief that in purchasing a projector, check resolution and image quality first.
Compare specs and pricing before buying your LCD TV projector.


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For the last 5 years Roger Shadbolt has been food product development manager for a food company that supplies to major UK retailers.
The food sector requires constant innovation, it's fast moving and demanding; yet despite this, innovation can sometimes be too formulaic.
The 'normal' process is that the retailer provides a brief based on food trends, customer insight and some indication on what they expect on their shelves. The supplier responds to the brief with a number of written ideas on which they receive feedback. Based on feedback the supplier provides 3 or 4 concepts in the next round complete with full factory costing, and from that final products are chosen and put into production. The process of brief to shelf can take anything from 6 months to a year.
When it comes to innovation, Roger was telling me how he was lucky because "I essentially had a great boss that gave me time and space to create"
"I was given time, a clear desk and clear headspace and I was allowed to time just for me. I put Radio 6 music on and started to create."
As Roger was creating that morning he pondered over his own breakfast needs.
"I love croissants but I don't have time on a work day to wait 15 minutes for the oven to heat up before I can reheat a store-bought product to eat for breakfast."
"I made a whole load of interesting shaped products in various loaf tins that would suit slicing for quick heating in the toaster like you would a normal slice of toast for breakfast"
Roger gave his boss a toasted piece of the sliced croissant loaf. He was thrilled. Roger shared his insights about wanting croissants for breakfast but not having time in the week to heat them up in the oven. He asked the question; "If this is the case for me, perhaps it's also true for other people – for other customers?" Roger realised the potential of this product as midweek and a weekend breakfast product.
They wondered if retail clients would be as thrilled as they were with the insight and the idea so they bypassed the normal processes and took their croissant loaf concept straight to their UK food retailer clients, They explained how a toasted croissant could be enjoyed mid-week before work without use of an oven to enjoy the product toasted and at its best. Their clients loved it and wanted to know when they could launch it!
Within weeks the croissant loaf was flying off the shelves. People loved it.
Croissant loaf rode on a food trend at the time of hybrid products inspired by Dominique Ansels' invention of the cronut (croissant/donut) followed by townies (tarts/brownies) and duffins (donut/muffins). Croissant loaf went on to win the Quality Food awards in the bakery morning goods category 2016. And all from Roger having the time and space to create a product that he wanted to create.
Deviate from 'normal'
The croissant loaf wasn't conceived in the conventional way. Roger wonders if they had presented their clients with a written concept version of the 'Croissant loaf suitable to toasting' if they might not have felt the thrill that they did by holding a warm toasted croissant dripping with butter and jam in their hand. Skipping some parts of the standard launch process bought the product to life and made it exciting. The client teams saw the potential straight away and were excited from the start. Plus on a practical note it keeps longer and has fewer calories per slice than a 'normal' croissant.
"Innovation breeds innovation"
The good sales figures off the back of media attention encouraged Roger and his team to innovate more. There was real excitement, which drove aspiration and momentum for innovation. People were more open to thinking differently, deviating from the norm and bending the rules.
"Breaking the process rules once which resulted in successful sales and media attention gave us ambition and confidence to look for other new innovation."
The development of the croissant loaf was not all plain sailing. The team at the factory that had made traditional croissants for 20 years weren't keen at first. They didn't want to use the machinery differently. Roger had to get the factory managers and their teams to buy into the idea.
He had to put his excitement about his idea to one side and help them to get as excited as him. He let them take ownership, work out how to best produce croissant loaf and he gave them ownership of developing the packaging. He was careful not to micromanage or be too prescriptive. He let them develop the best solution. Eventually the whole site was on his side working to get croissant loaves on the shelves.
Rogers's 7 innovation tips
- Work on what interests you right now and make that happen. It's really important to do something that interests you.
- Don't think too much. Don't wait to start. Start right away.
- Don't get muddled in number crunching – get the first version down.
- Version 1 is never the final version. You might end up with something totally different along the line.
- Get everyone excited.
- There are many barriers and there is never a right time.
- Rogers advice to managers is to give someone a task and let them get on with it. Deliberately factor in time for them with nothing to do. Book 'off timetable' time in. It's the only way to really get creative.
- Take the pressure off and play – if Rogers first iteration of croissant loaf had needed to be customer ready it would have looked different and probably wouldn't have happened.
- When people experience an idea they 'get it' much easier than a boring process and paper drawings – do what you can to bring your idea to life.
For more on Roger Shadbolt go to www.rogershadbolt.co.uk.
If you'd like to learn more insights from other successful innovators check out the new Innovation Leadership Launchpad – a mix of case stories and practical tips to help you innovate. Order your free copy straight into your inbox today.


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|Successful Submission
The June Cook-off has ended.
The editorials for the contest can be found here.
The Winners blog can be found here.
All the solutions for the problem set are public and the problems have been moved to practice section.
In case you are a new user, you will need to first register for a CodeChef ID here.
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- You will receive one point for solving a problem (passing all test cases - no partial credit), regardless of the level of difficulty of that problem.
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17/06/2012, 22:00 IST : Due to some technical issues, we are taking the site down for 10 minutes. We will be extending the contest. Regret the inconvenience caused.
17/06/2012, 22:17 IST :Â The site is back online. The site had gone extremely slow. It should be working fine now. We are embarrassed and we deeply regret the inconvenience caused. We have extended the contest by 10 minutes.
17/06/2012, 22:21 IST : The rankings for the contest can be found here.
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The Important Changes That Are Happening To OSHA 10 Training
It is already a given fact that when it comes to being the only most popular course for safety training, the OSHA 10 training program, or sometimes called as the OSHA 10 Outreach Training is the number one on the list..Due to the fact that OSHA training program has been accepted and received quite fairly in many places all over the world which lead to its widespread popularity, the course has since then mandated by various government and authorities of different countries across the globe and according to the latest statistics, there is over one point six million of students who have been trained in the said program for the last three years You can guarantee that you will be able to learn everything there is that needs to be learned and understand the things that needs better understanding since the trainers and instructors hired for the said training program are all authorize to do so as they have already completed all required training to teach. On the side of the students who partake on the said training course, they will receive on OSHA ten hour card as a proof that they have completed and finished all the programs under the course, and this will be given right after their completion.
Before, when you want to enroll yourselves in the courses under the OSHA ten training program, you actually have to options which are the following: the webinar, or properly known as video conferencing as the said course is also available online or; you can go to class as this course is also being taught by instructors and trainers. If you want to undergo the OSHA ten training program, there is no need for you to look far away as even in the state you belong to, you can find one since OSHA has been made available in every cities, states and even authorized instructors across the globe. Almost all of the course have been delivered for the whole duration of ten hours per day. However, all of this things changed effectively last October one, two thousand and ten.
One of the changes that happened to the previous terms and conditions governing the OSHA ten training program is the prevention of any authorized OSHA instructors to deliver the training in ten hours or more. That means that no one can have the chance of taking OSHA training course and complete it for a whole day of training session since it is mandated that such a thing must be stopped.
Finding Parallels Between Training and Life
This is due to the fact that OSHA, who already considered to possibility that students may not be able to absorb the training in the best way possible, no longer believe of the possibility that students will be able to retain safety training in ten hours or more. This is also the very reason why OSHA decided to limit the training to a much more reasonable time increment as it will more likely lead to a more effective and more efficient OSHA ten training program.6 Facts About Resources Everyone Thinks Are True


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New E-Commerce Law in Saudi Arabia
Published: 29/07/2019
Saudi Arabia recently issued its new e-commerce law. The E-Commerce Law, which will be administered by the Ministry of Commerce & Investment, comes into effect in late October 2019, 90 days following its publication in the Official Gazette on 24 July 2019. The associated Regulations are expected to follow shortly thereafter.
The Law focuses primarily on customer-protection related considerations, both in a B2C context and in a B2B context. It applies not only to e-commerce service providers who are merchants/traders registered in the Saudi Commercial Register, but also to other e-commerce practitioners – both in the Kingdom and elsewhere – who are not registered in the local Commercial Register. Specifically, e-commerce practitioners who are located outside the Kingdom, but who offer goods and services to customers based in the Kingdom, are subject to the Law.
- Minimum details: The Law sets-out minimum details that an e-store must display to customers. It requires e-commerce service providers to provide customers with clear contractual terms, and specifies minimum information that must be included. It also sets-out minimum requirements for invoices.
- Advertising: The Law provides that digital advertising by e-commerce service providers constitutes supplementary terms to the contract that are binding on the parties. It will be interesting to see what this means in practice.
- Rights to terminate: The Law specifies two general scenarios in which customers have a right to terminate an e-commerce contract. These can be understood broadly as a 'cooling off period' right to terminate; and a right to terminate in the event of a delay in delivery of the goods or services.
- Personal data protection: The Law contains general obligations with regard to the privacy of customer data.
- Enforcement and penalties: The Law permits MOCI to block access to an e-store in the event of violation of the Law or Regulations. Besides blocking access to the e-store, a variety of other penalties are available, including warnings, public notices, suspension of licences and fines.
The Law provides clarity for e-commerce service providers, although further clarity should follow when the Regulations are issued. In the meantime, e-commerce operators making goods and services available to customers in the Kingdom should prepare to review their customer terms and conditions and policies to ensure that they fit within the expectations set out in the Law.
Our TMT Practice
Our Technology, Media & Telecommunications ("TMT") team provides local and international clients with world-class, specialist legal support across the full spectrum of technology, media and telecommunications matters.
Our diverse team of internationally qualified lawyers combines local law experience with international best practice, having also had experience of working in-house. Working alongside the firm's Arabic-speaking lawyers and locally-qualified advocates, and with access to specialist lawyers from other practice areas, our TMT team provides clients with high quality, specialist legal services.
Key Contacts
Nick O'Connell
Partner, Head of TMT – KSA
Bandar Al Hamidani
Partner, Corporate Commercial


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In honor of Earth Day on April 22, we're highlighting packages that include volunteer opportunities, charitable donations, and discounts for driving a hybrid in Boston, L.A., New York, Costa Rica, and beyond.
Don't miss these Travel stories
Lords of the gourd compete for Punkin Chunkin honors
With teams using more than 100 unique apparatuses to launch globular projectiles a half-mile or more, the 27th annual World Championship Punkin Chunkin event is our pick as November's Weird Festival of the Month.
- Airports, airlines work hard to return your lost items
- Expert: Tourist hordes threaten Sistine Chapel's art
- MGM Grand wants Las Vegas guests to Stay Well
- Report: Airlines collecting $36.1B in fees this year
- Lords of the gourd compete for Punkin Chunkin honors
You can find out about major Earth Day celebrations around the globe—and ways to take action and make your everyday life more environmentally friendly—through the Earth Day Network.
Olympic National Park, Wash., from $109 per room per night
The Lake Quinault Lodge is offering an Earth Day Volunteer Vacation that includes accommodations, a volunteer experience from 9 a.m. to 4 p.m., and an included barbecue with your fellow volunteers afterward. You'll help clean up and restore the Kestner Homestead, a 120-year-old historic site in the Quinault Rain Forest. As a bonus, if you drive a hybrid car, you'll receive a $15 gift certificate for use in the lodge's store or restaurant. Rates start at $109 per room; add nights from just $89 per room.
When: April 24–25, 2009.
Details: Does not include taxes of 11 percent. Based on single or double occupancy.
Contact: 888/896-3827, visitlakequinault.com.
Ithaca, N.Y., from $120 per room per night
The Climbing Vine Cottage, about 10 minutes south of Ithaca, has a buy-one-get-one-free offer for people who drive hybrid vehicles. The cottage is actually a yurt surrounded by a garden, along with a pond, a forest, and a gorge a few steps away. There's also a full kitchen and free Wi-Fi. Rates start at $120 per room per night; if you drive a hybrid, your second night is free.
When: Through May 10, 2009.
Details: Does not include taxes of 11 percent. Based on occupancy of up to six people. Requires a two-night stay.
Contact: 607/564-7140, climbingvinecottage.com.
Costa Rica, from $135 per room per night
The La Cusinga Eco Lodge uses solar and water power to generate all its electricity and to heat the building's water. The eight-room lodge is in Uvita, in southwestern Costa Rica, next to Ballena Marine National Park, a virgin rain forest. Take a three-hour hike through the forest or simply stroll along the Pacific coast. The lodge's restaurant uses food grown in its own gardens and other locally sourced organic products. Rates start at $135 per room per night.
Slideshow: Misty mountains
When: Ongoing.
Details: Rate includes taxes and breakfast. Based on double occupancy; single occupancy rate starts at $107.
Contact: 786/427-2079, lacusingalodge.com.
New Orleans, from $159 per room per night
The New Orleans Marriott is offering a Spirit to Serve Voluntourism Getaway that includes breakfast and a $50 donation to the local Habitat for Humanity. The hotel's concierge will recommend local charities where you can volunteer if you so choose—and will help you coordinate the details. The hotel is in the French Quarter near Bourbon Street. Rates start at $159 per room per night.
When: Through Oct. 29, 2009.
Details: Does not include taxes of 13 percent and a $3 occupancy tax per night. Based on single or double occupancy. Use promo code P54.
Contact: 888/364-1200, marriott.com.
L.A., from $220 per room per night
Each night at dusk, the Sofitel Los Angeles turns off lights in public areas for one hour to conserve energy. The staff lights candles in the lobby, restaurant, and bar, and encourages guests to turn off their own lights and hang out in the public areas. The 295-room hotel has views of the famous Hollywood sign. Rates start at $220 per room per night.
When: Ongoing.
Details: Does not include taxes of 14 percent. Based on single or double occupancy.
Contact: 310/278-5444, sofitel.com.
Boston, from $229 per room per night
The Save Green package at the Renaissance Boston Waterfront Hotel includes accommodations, free parking, a Boston Harbor walking map and guide, a coupon book, two glasses of organic wine at 606 Congress, and a donation of $10 to the Juma rain forest in Brazil, which Marriott has pledged $2 million to protect. Rates start at $229 per room per night.
When: April 22–Sept. 7, 2009.
Details: Does not include taxes of 12 percent. Based on single or double occupancy. Use promo code PX3.
Contact: 800/468-3571, marriott.com.
Expedia has launched a special guide to green travel that includes green hotel recommendations.
If you're interested in voluntourism (volunteering while you travel), consider the following tour operators:
Global Exchange Reality Tours has a socially conscious, politically aware approach to tours in locations like Afghanistan, Colombia, and India. Groups tend to average 15 to 20 people, who run the gamut from youths to college and grad students to retirees. You'll do some volunteering with local groups in each tour.
United Planet runs environmental programs in Ecuador, India, and Costa Rica. Projects focus on environmental education and conservation and ecotourism, particularly sea turtle habitat preservation. Read more about the company's environmental programs here.
G.A.P Adventures is highlighting its voluntours and sustainable tours for the entire month of April. The company runs tours with volunteering opportunities in Costa Rica, Peru, Tanzania, and more.
For programs closer to home, check out the offerings available through Earthwatch, American Hiking Society, and Oceanic Society—organizations that, among other things, operate trips that benefit the local environment and community.
Copyright © 2012 Newsweek Budget Travel, Inc.


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The modern job landscape has changed immensely from having to go in to a factory or office to having much more freedom than in the past. The main aspect of life to give credit for this is that of technology as people can have face to face meetings online.
There are even studies that show working from home can help morale of an employee as well as their productivity if they are intrinsically motivated.
Working without having a manager look over your shoulder can be freeing and allow you to do your best quality work. The following are jobs where you get to have quite a bit of freedom.
1. Truck Driving or Uber
There are plenty of people that make money on a daily basis by driving for Uber. This does not guarantee a certain amount of money as many areas do not have Uber available or there are too many drivers. What many people do see is the trucking jobs on the rise throughout the country.
Many trucking jobs allow you to make your own schedule and pick what times you will be driving. Many drivers pick the night shift as they can be paid more and the traffic is generally much less stressful during these times. This can be a great way to see the country while enjoying the open road.
2. Freelance Writing
The life of a freelance writer can be very relaxing as well as profitable. Quality writers are constantly in demand for a variety of content whether it is a blog post or an ecommerce company needing product descriptions done.
Consistency is the name of the game when it comes to freelance writing as being able to stabilize income allows a freelancer to budget effectively. Writing is a skill that can be developed over time and will improve with the more you write as long as you are given constructive feedback.
Upwork is a great example of a freelancer platform that connects clients and writers so try your luck here. You might start out making less than you believe your work is worth but as your rating increases you can start asking more for the same job.
3. Web Designer
The web designer and developer have nearly always had a huge amount of freedom. The fact that many people do not know how to correct these people or what is happening have been great for the freedom of these professionals.
Much like the freelance writer you can take odd jobs but many companies are willing to pay developers or designers to work remotely for the right rate.
For these types of jobs deadlines are crucial as missing a few of these can lead to a company wanting you in the office or looking for another designer.
4. Sales
There are people who are sales machines whether they are in the office or they are left at home to sell.
Independent insurance agents are the perfect example of this as they can sell their product over the phone or online. The positive of using an independent agent is that they are not forced to use a specific company and can customize your plan to your needs in a better way.
Reaching out by phone or email does not require an office as sales teams for the same company are scattered across the country in many cases. There might be a yearly or biannual meeting of the sales team but if everything is going great management will usually leave everyone to keep selling.
The above careers offer quite a bit of freedom which many people seek on a daily basis. Going into an office will always be an option but it will never be the best one for many professionals. Start working from home if possible to see how much it can add to your daily life.


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SLS & Associates, Inc.
SLS & Associates, Inc.
B.S.C.E., with honors, University of Kentucky, 1968
M.S.C.E., University of Kentucky, 1973
• Registered Professional Engineer in Florida, 1974
• Past Chairman of the Geotechnical and Material Engineers
• Member of the Florida Engineering Society and American
Society of Civil Engineers
Mr. Sonnenfeld has served as a senior project manager for various major projects. He has
provided consulting engineering, design, and testing services for a wide variety of
construction projects. He has also been active in training technicians who are seeking
certification as concrete and aggregate testing.
• More than 30 years experience in the construction throughout Florida, which include
subsurface studies, development and interpretation of specifications, design services for
maintenance of traffic, evaluation of groundwater conditions, foundation systems, as well as
value engineering services
• Project management experience for geotechnical studied for large projects: runway
restorations at Tampa International Airport, 300 Million dollar chemical plant expansion, Old
Tampa Stadium Expansion, and the Florida Suncoast Dome and numerous mid rise
condominium structures.
• In conjunction with his professional assignments, he has published papers on various
testing procedures. Also, he has taught classes at the University of South Florida as an
adjunct professor.
• Provided geotechnical services for scores of miles of Interstate Highway (I-75, I-275 and
10), tens of miles of bridges, miles of earthen dam, numerous mid to high rise structures.
Also, has been involved in the design of cutoff walls to inhibit the migration of methane gas
from landfills and evaluation of the flow pattern of pollutants from landfill operations.
• Developed Quality Control and Quality Assurance plans for CMT laboratories. Also, he has
written and implemented such plans for large projects and selected clients.
• Designed various types of foundation systems for use in transmission line construction.
These designs included evaluation of vibrated in-place steel piles, precast, concrete cylinder
piles, and drilled shafts. Also, he has provided design services for earth work construction.
• Provided engineering services to aid in minimizing delays in earthen construction, including
various utility and pipe projects. These studies also included development of alternate
procedures to aid in reducing man power and equipment requirements.
• Served as arbitrator in construction related disputes, as well as, providing engineering
services during mediation and trial for large roadway and vertical construction projects.
• For over 15 years taught classes to hundreds of field and laboratory technicians seeking
ACI accreditation in concrete and/or aggregate testing. Also, during this period he has
served as the examiner at numerous ACI examinations.
US Army (1968 to 1970) - Sgt E5, 9th Infantry Division, in charge of road reconnaissance,
Long Ann Province, Viet Nam.
Don Perkins & Associates (1971 to 1972) Staff engineer, performed geotechnical studies for
highway construction
Law Engineering (1973 to 1979) Senior engineer, in charge of geotechnical studies for roads,
bridges, industrial and commercial development
Williams & Associates (1979 to 1988) Engineer in responsible charge of testing laboratory
operations, which included both geotechnical and material engineering services
SLS & Associates (1988 to present) Principal in charge of business development, provide
engineering and training services
Spillway Failure of Settling Pond


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Piet Mondrian, Superb Artist Of The Early 20th Century
Discussion, unique works (please host with imgur) and pictures of the works of others. Abstract artwork emphasized on creating the artwork and not the completed artwork itself. Madhubani artwork Travel portrays a pictorial narration of mythological and spiritual events, celebration of festivals and detailing of celestial bodies-sun and moon in a traditional amazing format.
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