text:
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
From WikiPathways
Pro-apoptotic transcriptional targets of TP53 involve TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010).
TP53 regulates expression of a number of genes involved in the intrinsic apoptosis pathway, triggered by the cellular stress. Some of TP53 targets, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and probably BNIP3L, AIFM2, STEAP3, TRIAP1 and TP53AIP1, regulate the permeability of the mitochondrial membrane and/or cytochrome C release (Miyashita and Reed 1995, Oda et al. 2000, Samuels-Lev et al. 2001, Nakano and Vousden 2001, Sax et al. 2002, Passer et al. 2003, Bergamaschi et al. 2004, Li et al. 2004, Fei et al. 2004, Wu et al. 2004, Park and Nakamura 2005, Patel et al. 2008, Wang et al. 2012, Wilson et al. 2013). Other pro-apoptotic genes, either involved in the intrinsic apoptosis pathway, extrinsic apoptosis pathway or pyroptosis (inflammation-related cell death), which are transcriptionally regulated by TP53 are cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10 (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007).
It is uncertain how exactly some of the pro-apoptotic TP53 targets, such as TP53I3 (PIG3), RABGGTA, BCL2L14, BCL6, NDRG1 and PERP contribute to apoptosis (Attardi et al. 2000, Guo et al. 2001, Samuels-Lev et al. 2001, Contente et al. 2002, Ihrie et al. 2003, Bergamaschi et al. 2004, Stein et al. 2004, Phan and Dalla-Favera 2004, Jen and Cheung 2005, Margalit et al. 2006, Zhang et al. 2007, Saito et al. 2009, Davies et al. 2009, Giam et al. 2012).
TP53 is stabilized in response to cellular stress by phosphorylation on at least serine residues S15 and S20. Since TP53 stabilization precedes the activation of cell death genes, the TP53 tetramer phosphorylated at S15 and S20 is shown as a regulator of pro-apoptotic/pro-cell death genes. Some pro-apoptotic TP53 target genes, such as TP53AIP1, require additional phosphorylation of TP53 at serine residue S46 (Oda et al. 2000, Taira et al. 2007). Phosphorylation of TP53 at S46 is regulated by another TP53 pro-apoptotic target, TP53INP1 (Okamura et al. 2001, Tomasini et al. 2003). Additional post-translational modifications of TP53 may be involved in transcriptional regulation of genes presented in this pathway and this information will be included as evidence becomes available.
Activation of some pro-apoptotic TP53 targets, such as BAX, FAS, BBC3 (PUMA) and TP53I3 (PIG3) requires the presence of the complex of TP53 and an ASPP protein, either PPP1R13B (ASPP1) or TP53BP2 (ASPP2) (Samuels-Lev et al. 2001, Bergamaschi et al. 2004, Patel et al. 2008, Wilson et al. 2013), indicating how the interaction with specific co-factors modulates the cellular response/outcome.
TP53 family members TP63 and or TP73 can also activate some of the pro-apoptotic TP53 targets, such as FAS, BAX, BBC3 (PUMA), TP53I3 (PIG3), CASP1 and PERP (Bergamaschi et al. 2004, Jain et al. 2005, Ihrie et al. 2005, Patel et al. 2008, Schilling et al. 2009, Celardo et al. 2013).

For a review of the role of TP53 in apoptosis and pro-apoptotic transcriptional targets of TP53, please refer to Riley et al. 2008, Murray-Zmijewski et al. 2008, Bieging et al. 2014, Kruiswijk et al. 2015. View original pathway at:Reactome.

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- Pathway is converted from Reactome ID: 5633008
- Reactome-version
- Reactome version: 66
- Reactome Author
- Reactome Author: Orlic-Milacic, Marija
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External references
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|Database reference
|(p-S15,S20-TP53,TP63):PERP Gene
|R-HSA-6800835 (Reactome)
|(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene
|R-HSA-3700978 (Reactome)
|(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene
|R-HSA-4331345 (Reactome)
|(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):FAS Gene
|R-HSA-6799810 (Reactome)
|(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):TP53I3 Gene
|R-HSA-6799461 (Reactome)
|R-HSA-6799788 (Reactome)
|(p-S15,S20-TP53,TP63,TP73):CASP1 Gene
|R-HSA-6798078 (Reactome)
|CHEBI:34055 (ChEBI)
|CHEBI:16761 (ChEBI)
|AIFM2 Gene
|ENSG00000042286 (Ensembl)
|AIFM2 Gene
|ENSG00000042286 (Ensembl)
|Q9BRQ8 (Uniprot-TrEMBL)
|APAF1 gene
|ENSG00000120868 (Ensembl)
|APAF1 gene
|ENSG00000120868 (Ensembl)
|O14727 (Uniprot-TrEMBL)
|CHEBI:15422 (ChEBI)
|Apoptotic execution phase
|R-HSA-75153 (Reactome)
|In the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucleus and other organelles, DNA fragmentation, chromatin condensation, cell shrinkage and cell detachment and membrane blebbing (reviewed in Fischer et al., 2003).
|BAX gene
|ENSG00000087088 (Ensembl)
|BAX gene
|ENSG00000087088 (Ensembl)
|Q07812 (Uniprot-TrEMBL)
|BBC3 Gene
|ENSG00000105327 (Ensembl)
|BBC3 Gene
|ENSG00000105327 (Ensembl)
|Q9BXH1 (Uniprot-TrEMBL)
|BCL2L14 Gene
|ENSG00000121380 (Ensembl)
|BCL2L14 Gene
|ENSG00000121380 (Ensembl)
|Q9BZR8 (Uniprot-TrEMBL)
|BCL6 Gene
|ENSG00000113916 (Ensembl)
|BCL6 Gene
|ENSG00000113916 (Ensembl)
|P41182 (Uniprot-TrEMBL)
|BID Gene
|ENSG00000015475 (Ensembl)
|BID Gene
|ENSG00000015475 (Ensembl)
|P55957 (Uniprot-TrEMBL)
|BIRC5 Gene
|ENSG00000089685 (Ensembl)
|BIRC5 Gene
|ENSG00000089685 (Ensembl)
|O15392 (Uniprot-TrEMBL)
|BNIP3L Gene
|ENSG00000104765 (Ensembl)
|BNIP3L Gene
|ENSG00000104765 (Ensembl)
|O60238 (Uniprot-TrEMBL)
|O60238 (Uniprot-TrEMBL)
|CASP1 Gene
|ENSG00000137752 (Ensembl)
|CASP1 Gene
|ENSG00000137752 (Ensembl)
|P29466 (Uniprot-TrEMBL)
|CASP10 Gene
|ENSG00000003400 (Ensembl)
|CASP10 Gene
|ENSG00000003400 (Ensembl)
|Q92851 (Uniprot-TrEMBL)
|P42575 (Uniprot-TrEMBL)
|P42575 (Uniprot-TrEMBL)
|P42575 (Uniprot-TrEMBL)
|P42575 (Uniprot-TrEMBL)
|P55212 (Uniprot-TrEMBL)
|CASP6 Gene
|ENSG00000138794 (Ensembl)
|CASP6 Gene
|ENSG00000138794 (Ensembl)
|P24386 (Uniprot-TrEMBL)
|P24386 (Uniprot-TrEMBL)
|P78560 (Uniprot-TrEMBL)
|P78560 (Uniprot-TrEMBL)
|Q92793 (Uniprot-TrEMBL)
|Q92793 (Uniprot-TrEMBL)
|FAS Gene
|ENSG00000026103 (Ensembl)
|FAS Gene
|ENSG00000026103 (Ensembl)
|P25445 (Uniprot-TrEMBL)
|FasL/ CD95L signaling
|R-HSA-75157 (Reactome)
|The Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the transduction of the external signal to the cytoplasmic side of the cell membrane. The most notable cytoplasmic domain is the Death Domain (DD) that is involved in recruiting the FAS-associating death domain-containing protein (FADD). This interaction drives downstream events.
|CHEBI:15378 (ChEBI)
|IGFBP3 Gene
|ENSG00000146674 (Ensembl)
|IGFBP3 Gene
|ENSG00000146674 (Ensembl)
|P17936 (Uniprot-TrEMBL)
|R-HSA-6800024 (Reactome)
|P17936 (Uniprot-TrEMBL)
|Innate Immune System
|R-HSA-168249 (Reactome)
|Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
|Interleukin-1 processing
|R-HSA-448706 (Reactome)
|The IL-1 family of cytokines that interact with the Type 1 IL-1R include IL-1α (IL1A), IL-1β (IL1B) and the IL-1 receptor antagonist protein (IL1RAP). IL1RAP is synthesized with a signal peptide and secreted as a mature protein via the classical secretory pathway. IL1A and IL1B are synthesised as cytoplasmic precursors (pro-IL1A and pro-IL1B) in activated cells. They have no signal sequence, precluding secretion via the classical ER-Golgi route (Rubartelli et al. 1990). Processing of pro-IL1B to the active form requires caspase-1 (Thornberry et al. 1992), which is itself activated by a molecular scaffold termed the inflammasome (Martinon et al. 2002). Processing and release of IL1B are thought to be closely linked, because mature IL1B is only seen inside inflammatory cells just prior to release (Brough et al. 2003). It has been reported that in monocytes a fraction of cellular IL1B is released by the regulated secretion of late endosomes and early lysosomes, and that this may represent a cellular compartment where caspase-1 processing of pro-IL1B takes place (Andrei et al. 1999). Shedding of microvesicles from the plasma membrane has also been proposed as a mechanism of secretion (MacKenzie et al. 2001). These proposals superceded previous models in which non-specific release due to cell lysis and passage through a plasma membrane pore were considered. However, there is evidence in the literature that supports all of these mechanisms and there is still controversy over how IL1B exits from cells (Brough & Rothwell 2007). A calpain-like potease has been reported to be important for the processing of pro-IL1A, but much less is known about how IL1A is released from cells and what specific roles it plays in biology.
|Intrinsic Pathway for Apoptosis
|R-HSA-109606 (Reactome)
|The intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stresses in the endoplasmic reticulum and death receptor stimulation. Following the reception of stress signals, proapoptotic BCL-2 family proteins are activated and subsequently interact with and inactivate antiapoptotic BCL-2 proteins. This interaction leads to the destabilization of the mitochondrial membrane and release of apoptotic factors. These factors induce the caspase proteolytic cascade, chromatin condensation, and DNA fragmentation, ultimately leading to cell death. The key players in the Intrinsic pathway are the Bcl-2 family of proteins that are critical death regulators residing immediately upstream of mitochondria. The Bcl-2 family consists of both anti- and proapoptotic members that possess conserved alpha-helices with sequence conservation clustered in BCL-2 Homology (BH) domains. Proapoptotic members are organized as follows:
1. "Multidomain" BAX family proteins such as BAX, BAK etc. that display sequence conservation in their BH1-3 regions. These proteins act downstream in mitochondrial disruption.
2. "BH3-only" proteins such as BID,BAD, NOXA, PUMA,BIM, and BMF have only the short BH3 motif. These act upstream in the pathway, detecting developmental death cues or intracellular damage. Anti-apoptotic members like Bcl-2, Bcl-XL and their relatives exhibit homology in all segments BH1-4. One of the critical functions of BCL-2/BCL-XL proteins is to maintain the integrity of the mitochondrial outer membrane.
|Iron uptake and transport
|R-HSA-917937 (Reactome)
|The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).
|CHEBI:18009 (ChEBI)
|CHEBI:16474 (ChEBI)
|NDRG1 Gene
|ENSG00000104419 (Ensembl)
|NDRG1 Gene
|ENSG00000104419 (Ensembl)
|Q92597 (Uniprot-TrEMBL)
|NLRC4 Gene
|ENSG00000091106 (Ensembl)
|NLRC4 Gene
|ENSG00000091106 (Ensembl)
|Q9NPP4 (Uniprot-TrEMBL)
|CHEBI:18421 (ChEBI)
|CHEBI:15379 (ChEBI)
|CHEBI:16337 (ChEBI)
|PERP Gene
|ENSG00000112378 (Ensembl)
|PERP Gene


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The actual problem with the Greek debt crisis is the exhorbitant, gigantic, unsustainable Interest Rates the Greek nation is being charged to keep its dealings afloat. Such high interest rates simply would sap the energy of anybody. Doesn't it make the people charging it feel guilty? Imagine giving such a high interest loan to someone in the neighbourhood, and seeing their daily struggle for survival.
The Greeks are a proud and noble people, polite and long-suffering under the circumstances.
I believe if the interest rates being charged them are reduced to a sustainable, survivable rate so the idea of a default can be virtually counted out, it would prove a great sigh of relief and enable that nation get back on its feet. In helping the Greek nation, all will be aiding their own strength as well.
Anyway, as always, I pray for a kind solution for them as well.

subset: commoncrawl


text:
2016 EJBSL Golf Tournament Entry Form
Use this form to register individuals or teams for the golf tournament.
EJBL Consent Form
To be completed by all EJBL players.
EJBL Code of Conduct
For coaches, players, and parents
Babe Ruth Insurance Claim Form
Complete this form to submit any insurance claims.


text:
Colin's List Of Worldwide Israeli Dancing Events
Saturday, 1 August 2020
11 Av 5780
Fête Nationale Suisse/Bundesfeier/Festa Federale
Machol Hashalom
Where: CREPS Wattignies 11 rue de l'Yser - 59130 WATTIGNIES
Saturday, 1 August 2020
Time: 16:30 - 10:34 GMT
Import this event into your Outlook calendar
MECHOL HASHALOM 2020 - European Ifd Summer Camp
WITH : Elad Shtamer, Eli Segal, Michael Barzelai, Oren Ashkenazi, Benny Assouline, Caroline Hoffrand.
WHEN : Monday July 27 (4.30 pm) - Saturday, august 1 (10:30 am)
Registration starts at 2.00 pm on Monday.
ADDRESS : CREPS Wattignies
11 rue de l'Yser - 59130 WATTIGNIES (France)
LEVELS : Beginner - Intermediate - Advanced
Participants will be divided in 3 groups and will work in 3 different gymnasiums.
Prices include: accommodation in shared rooms (2 or 4 beds). Single rooms (with extra charge), full board, meals, snacks, buffets, hot and cold drinks, courses, workshops, music of the camp.
Online payment, forms, registrations, newsletters. More information on our website www.horaor.org
THIS YEAR'S THEME : Hippie - Love, Peace and Joy
Last updated on: 17/04/2020 at 09:46
Licensed To:
Untitled Document
To add your event send an email with full details to the above address.


text:
Earn points toward FREE PIZZA with Piece of the Pie Rewards
More About Domino's Near Belcher
Destination? Delicious Pizza Near Belcher
When your tastebuds are tingling for a delicious slice of cheesy, meat-topped goodness, we know you're not craving any old pizza near Belcher. You want a scrumptious pizza prepared with a flavorful tomato sauce, perfectly sliced chunks of pepperoni, generous piles of mozzarella and parmesan, and a golden-brown crust that's both crispy and chewy. You want a pizza that makes your dinner dreams come true. You want Domino's.
At Domino's near Belcher, we make it quick and simple to get the fast, fresh pizza your hunger craves. Visit your nearest Domino's location to place a carryout order, give us a call, or order your pizza online!
Start off by picking from our menu of crusts. Choose a fluffy, hand-tossed crust that's dusted with garlic seasonings and buttery flavor, a gluten-free crust, a crunchy thin crust, or a pan pizza crust that's loaded with two layers of melted cheese! And then, select your sauce and start loading up on the pizza toppings of your choice. Whether you're a serious fan of mushrooms and spinach or love spicy pepperoni and tangy asiago cheese, your pizza dreams can come true at your nearest Domino's.
With over 34 million different ways to make a single Domino's pizza, you can be sure we've got a slice for any taste. Build your own pizza from scratch or choose from one of our specialty pizzas, like the popular Spinach and Feta, Cali Chicken Bacon Ranch, or MeatZZa™, and have it delivered to your doorstep, today!
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Visit one of our more than 12,000 locations around the world and you'll see: we know what it means to provide great customer service and even better food quality. It's our goal to be the best pizza delivery company in the world, not only in Louisiana, and everything from our courteous delivery drivers to our stellar pizza coupons reflects this commitment. Call your local Domino's restaurant near Belcher, use our free smartphone app, or place your order online for fast pizza delivery and carryout today! We're different than other pizza restaurants. We're your number one pizza place near Belcher!


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Sheila Radziewicz Born Without Arms, Getting Her Black Belt
Get Motivated: Born Without Arms and Getting a Black Belt
I know there are days when you don't feel motivated to work out, but this story is sure to get you off your couch. Sheila Radziewicz began training in martial arts three years ago, and next month she's testing to earn a black belt in tae kwon do. A feat unto itself, but Sheila is doing it essentially without arms. She has a rare genetic disorder known as thrombocytopenia absent radius, or TAR syndrome. Characterized by the absence of the radius bone in the forearm, the severity of this genetic condition varies among people with the syndrome. Sheila's arms formed such that her hands are near her shoulders. With TAR syndrome, it's common to have other structural malformations, and the soon-to-be black belt was also born without kneecaps.
Sheila never let her disability stop her from doing anything. Sheila says, "I grew up with the phrase, 'The impossible only takes a little longer.'" The 32-year-old was told she wouldn't survive; then told she wouldn't walk. Now, despite her condition, her tae kwon do instructor explains, "She can use nunchucks and break boards with her kicks." With determination and a can-do attitude, you can accomplish many goals that seem beyond you. I love her mantra too!


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Goodreads / Amazon / iBooks / Kobo / Google Play
Beholder CRADLED
Excerpt: Meeting the Lightning Goddess
"It's the round gateway," I whispered. "The one from Jicho's vision." I repeated the boy's prophecy once more.
"Watch for the round gateway; it will bring you the lightning goddess and her consort."
Rowan scanned the loop of brightness as it whirled above our heads. "If that's a gateway, then I've never seen anything quite like it."
Heavy silence filled the central feasting hall. The swirl of light by the ceiling flared more brightly, casting odd shadows onto the tapestries and floor. A charged sense of anticipation hung in the air.
I shared a quick glance with Rowan. Every line of his rugged face was tight with determination.
Light pulsed in the center of the round gateway as a man and a woman tumbled through, landing on the floor in a crouch. Although their backs were facing us, I could still make out some basics about the pair. The woman was tall as me but far more curvy. Her long auburn hair cascaded down her back. The man beside her was broad shouldered and fit with short brown hair. Both of them were wore black body armor like none I'd ever seen before. It appeared not to be flexible. Interesting.
Something twitched behind the woman, and that's when I noticed it. She had a tail. It was long, black, and covered in some kind of scales. The end was as pointed as an arrow.
In our realm, we did have people with non-human body parts. They were called Changed Ones, and they were the unfortunate results of by brother Viktor's experiments in combining Casters with their animal familiars. My stomach sank. Was it possible that Viktor had somehow gotten to this woman and her realm?
The man lifted his right arm, and he was holding a severed head in his fist.
Wait, a head?
I rubbed my eyes, wondering if I was seeing things. But once I lowered my hands, the man was still there, his back facing to us. And he still gripped a severed head in his hand. And what a head it was. The thing had the profile of a humanoid pig with green skin and a pair of large curlicue horns growing out of each temple. The man gripped the head by a single horn.
"The good news is, we killed the phase demon." The man tossed the head onto the floor before him.
"The bad news is, he phased us somewhere before he died," added the woman. Her tail perked up and tapped her shoulder. The woman looked to the arrowhead end. "What's up, boy?"
The tail gestured toward me and Rowan as if to say: pay attention; there's something behind you.
The woman slowly turned around. "Hello there," she said. If she was shocked to be in a strange place, she didn't show it.
The man turned around as well. He had mismatched eyes—one blue and one brown—as well as strong bone structure. The pair of us were a study in opposites. I was thin and dark haired, while the woman was curvy with long reddish locks. The man was pale and regal looking. At the same time, Rowan may be a king, but he always looked tanned and rugged.
The woman waved at us. "I said, hello there."
"Hello," I replied. "I'm Elea and this is Rowan. Who are you?"
"I'm Myla," said the woman.
The man gave us a chin-nod. "Lincoln."
Rowan stepped forward. "Are you a lightning goddess, by any chance?"
"You could call me that," answered Myla.
I couldn't help but smile. Jicho's prophecy was coming true.
We are a group of authors,
August 2018


text:
Ryoichi Kurokawa, the pioneering Berlin-based digital artist, is set to give a one-off performance of his new audiovisual show Syn_ tonight at the BFI.
It's part of the institute's Sonic Cinema Series and is the result of a collaboration with London festival organisation Alpha-ville, who say: "Abandoning humanism and aesthetics, Syn_ explores abstract and musical patterns. In this work, simultaneity and synaesthesia - the correspondence of sensations and perceptions, such as sounds and colours, play masterfully on harmony and dissonance creating a show that many artists and avant-garde filmmakers - from Paul Klee and Norman MacLaren to Vassily Kandinsky had dreamed during the twentieth century, long before the appearance and the democratisation of digital technologies."
We picked out Kurokawa's installation at last year's Bozar Electronic Arts Fest as one of the event's highlights, so would urge readers to head to the BFI for the show's start at 7 pm - tickets will be available on the door. In advance of the performance, have a watch of the Syn_ teaser video below:


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Autism 'begins long before birth'
Scientists say they have new evidence that autism begins in the womb.
Patchy changes in the developing brain long before birth may cause symptoms of autism spectrum disorder (ASD), research suggests.
The study, in the New England Journal of Medicine, raises hopes that better understanding of the brain may improve the lives of children with autism.
This is the beginning of the article. If this is true, that it is something that develops as the brain develops, then... wow. That changes a lot of things about our understanding of autism.
It may also help explain why, when signs of autism are caught early on, therapy (speech, physical, occupational) can help more than when it's caught later in life.
As I'm sure most of you know by now, 2 of my 4 sons have autism. My older boy, who is 12, was 2 1/2 when he was diagnosed (original diagnosis: PDD-NOS[pervasive developmental disorders - not otherwise specified]. current: Aspergers), while my younger son (PDD-NOS), 11, was 18 months. I had noticed differences (different from "normal") in my younger one from birth, while my older one seemed to develop his differences later.
My younger son responded better to the various therapies, to the point where, unless you know what you are looking for, he's a "normal", if somewhat quirky, 5th grader. My older son still has problems with eye contact, speaking to people he doesn't know well (it was almost a full month before he could manage to say more than "hi" to his teacher this year), and has some peculiar mannerisms that are off-putting to many people.
I'm wondering now what the precise differences in their brains are vs. what they were. Which areas are the same between the two kids, which are different, which are different from neurotypical kids, etc.


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Generali's approach to emerging risks
In Generali, the strategy to be a lifetime partner requires us to look around and focus our attention on trends related to relevant topics, such as political, economic, social and legal, as well as to disruptive scientific and technological evolutions. Through our approach we aim at identifying and properly managing the "unknowns", both in terms of risks and of business opportunities.
We are managing our emerging risks within our broader Main Risk Self-Assessment process, coordinated by the Group Risk Management Function. The overall process involves a network of business specialists, which represents all main Group Business Functions, ranging from Underwriting, Investment and Operations, to Marketing and other expertise. Two major roles are played by Business Strategy and Group Sustainability & Social Responsibility with the purpose of granting both a strong integration with the defined business strategy and the increasing embedding of ESG factors within the risk management process.
All our Group Business Units, spread around the globe, are participating to this Group exercise. Coordinated by local Chief Risk Officers, they provide their own inputs to the risk identification process by focusing on the most relevant risks for their markets. These are assessed in terms of vulnerability, timeframe as well as risk management preparedness, ensuring coverage of all major ESG factors' interrelations in parallel. This grants a consistent risk-based approach for the Group Materiality Matrix definition as well.
From 2018, all Generali Group employees have been provided with a Booklet accessible from Generali internal website which allows them to have an insight on specific risks. They can both learn and comment on selected topics, regardless of their geographical and organizational position.
The overall Group Emerging Risk Register is updated on yearly basis, taking into account the results of the exercise performed at both Group Head Office and Business Unit level, as well as relying on the most relevant market studies on the major trends, among which, for example, the World Economic Forum.
Generali Group participates to the European CRO Forum – Emerging Risk Initiative (ERI), dealing with the most significant trends and risks for the European insurance industry and coordinating a publication on selected emerging topics on yearly basis. In early 2019 the document 'The Heat is On-Insurability and Resilience in a Changing Climate' has been published.
The 2019 Generali Group Emerging Risk Register maintains a predominant focus on climate change, geopolitical instability with related financial distresses and digitalization aspects. Compared to the previous year, a major focus is given to lifestyle developments and medical trends as well as to the internet of things (IoT).
A snapshot1 of some of the main risks which are considered particularly relevant for the industry is provided below.
1 This brief summary provides some of the elements discussed within the 2019 Generali Group Emerging Risk Register and it is not to be considered exhaustive in terms of overall emerging risk assessment, nor it is intended to rank all Group risks.
Climate change is, according to some evidences, already there. The most valuable scientific outcomes, among which IPCC2, provide it will increasingly exacerbate a number of natural phenomena. Depending on the level of increase in global temperatures, these can range from increased intensity of storms, tropical cyclones with higher wind speeds and precipitations, growing risk of inland flash floods, more frequent coastal flooding and major coastal erosion from storms and sea level rise, glacial retreat in mountainous areas, permafrost thawing, extensive species losses and more frequent heat-waves. The emerging nature of this risk is related to the difficulty of predicting where, when and the intensity of the damage (uncertainty typically referred to as "global weirding") and the complexity to forecast medium to long term developments.
Natural disasters go beyond the immediate physical risks and have a number of implications for the society and insurance industry. Financial markets are at risk of stranded assets, with an expected decrease in the value of those assets linked either to coal sector or to highly energy intensive sectors during the transition period (one of the so-called transition risks). On the other hand, green assets do represent new opportunities.
Life and health insurance products are not immune to climate and more generally pollution, heatwaves and unpleasant living conditions can also underlie what can progressively lead to a climate driven migration. Finally, insurance companies will have to increasingly monitor the liability exposures as new regulatory frameworks are being developed for, as an example, pollution liability.
Climate trends represent also a strategic driver for the whole industry, willing to continue providing the most adequate protection to the population and properly address its financial resources to foster a greener economy.
2 The Intergovernmental Panel on Climate Change (IPCC) is the United Nations body approaching climate change scenarios development.
International agreements are perceived to be less powerful, return of protectionism and regionalization, phenomena like large-scale migration, changes in global power balance, social inequality perception, increase of populism and extreme movements might lead to military conflicts, trade wars, social revolts and protests with a consequent destabilization of the world economy and of the financial markets.
Geopolitical instability could lead to tensions on food and energy prices, unemployment rates triggering social unrest as well as business interruptions. Another consequence of geopolitical instability could be the reduced trust in financial markets, with a decreasing appetite for financial products and an increasing number of lapses observed.
The increased frequency and velocity of these events, some of them disruptive like Brexit, is leading geopolitical instability to become the new reality.
Implications for financial markets and real economy might be very relevant. Geographical footprint is therefore a cornerstone of the strategic risk management process for financial institutions.
Higher volume, velocity and variety of data captured, acquired and integrated in today's enterprises require new thinking in data governance, including data processing, storage and data consumption. In such scenario, big data represents a very broad topic and can imply exacerbating risks such as cyber security (including silent cyber from insurance perspective) as well as business implications deriving from hyper-connectivity, accessible and cheaper computational power and artificial intelligence leveraging access to big data repositories (all these having increasingly relevant regulatory and reputational impacts).
"Big Data" as an emerging risk could be associated with both higher volumes and increased speed of the data to be analyzed and used in the future, by leveraging new data sources (such as software applications on mobile devices as well as billions of interconnected devices in the Internet of Things – IoT), artificial intelligence and higher computing capacities (e.g. super cloud services provide the option of storing significant amounts of data with high level of availability, scalability and limited fault tolerance). Big data have also huge potential to increase and make use of smart city services, processing data collected through network of IoT devices so that further analyses to recognize the patterns and needs in the city can be made.
The main risk is related to not using the data, the algorithms and the source networks that are becoming available within the business processes (e.g. related to changes in consumption habits) and of not being up-to-date with coming technologies. Data adequate management and protection is on the other hand a key operational challenge, with even increased regulatory and reputational implications when it involves sensitive and private data.
Autonomous machines include driverless cars which can already be seen on some roads, driverless public transportations, robots providing advice in shops and in online experiences, machines used in medical and surgery equipment, home and care assistants, drones, as well as weapons. Their introduction is expected to affect almost all sectors of the economy and lead to important new legal, regulatory, societal and ethical considerations.
In the motor business sector, self-driving cars or semi-autonomous cars are expected to disrupt the existing insurance model, reducing the frequency of claims and increasing the severity of new risks such as cyber. With this new mobility, car insurance will be increasingly a B2B business, between insurers and producers, while the cars directly owned by individuals could rapidly decrease with the parallel spread of a sharing economy.
Besides self-driving cars, malfunctions of autonomous machines are expected to be impacting a number of insurance lines of business, particularly relevant in case of infrastructural systems or highly sensitive sectors like the medical one. A particular attention will be also addressed to software owners and programmers: the ability to evaluate the impact of error in coding as well as the related impact on liabilities will be key in the future of insurers.
Hyper-connectivity within the new communication models refer to person-to-person, person-to-machine and machine-to-machine connections. The multiplication of data sources leads to an increased cyber risk exposure such as cyber-attacks, ranging from loss of data and information to increasingly relevant business interruptions. This is even exacerbated in case of sensitive data. Reputational damage within a hyper-connected world are related, for example, to the increasing spread of fake news and deep fake.
Internet of things is also about smart factories, strongly relying to hyper-connectivity for internal processes and customers relationships, as well as domotics or so-called smart homes, providing increased assistance and support to people within their homes. On the contrary, these smart homes represent an additional IT and cyber risk exposure.
Artificial intelligence (AI) and in general cognitive computing techniques are entering into almost every facet of society. They tend to the realization of machines able to solve the problems typically solved by human intelligence and rely on cognizing software, able to learn and accumulate information. The applications in AI insurance can be various. The interaction with the IoT sensors will provide personalized data to the tariff platforms, allowing users to pay a premium that best adapts to the risks related to a personalized lifestyle, for example, to pay less for motor insurance on the basis of the driver's risk tolerance or at the time of use of the vehicle or pay less health insurance in case of a healthier lifestyle. The complex nature and the high investment required could impact on long-term strategy in terms of companies' capability to generate future benefits.
Automation and use of production robots lead to considerable savings related to labour and production cost with platforms that easily help companies to introduce smart robotic process automation (Smart RPA). Robots work by replicating the activities that people currently undertake, using existing core systems, legacy applications, website accesses, and manipulating spreadsheets, documents and e-mails to complete tasks. Smart Robots add Artificial Intelligence to the core replication skills mentioned above. This automatization applies also to front-end business processes, providing the client with advice and consultancy services (so called robot advice).
Labour market is not immune to social and ethical implications given the reduced workforce demand as well as the resource exhaustion, due to the need of high level digital skills.
Within finance, similar applications are known as "flash investments" phenomena, which can generally impact the short-term volatility.
Changes in people lifestyle can be found in several aspects, such as lack of sleep, smart and other drugs' abuse, obesity, malnutrition, sedentary habits and also, on the other side, increased interest in wellbeing. This implies for insurers the need to foster promotion of wellbeing and quality of life, also with the support of digital data and, for example, partnerships with gyms, diet and fitness advisors as well as health care providers.
In this evolving context, the medical developments represent a significant trend for the society, impacting individuals, health systems and, least but not last, insurance industry given its social role. Predictive analysis, the way in which health services are provided (telemedicine, etc.) and the development of artificial intelligence in health are driven by the use of technology/automated processes in the diagnosis and treatment of patients who require care. For example, robots have been developed to perform a wide range of tasks and functions: from simple laboratory robots to highly complex surgical robots that can either aid a human surgeon or execute operations by themselves. Robots are also used in hospitals and laboratories for repetitive tasks, in rehabilitation and in physical therapy. Moreover, nanotechnology is a hot-topic in medicine, aiming to kill a broad range of harmful microbes but also producing new sensors that can detect whether a person has certain types of cancer from only a few drops of blood. Other examples of the technological developments in medicine can be CRISPR (clusters of regularly interspaced short palindromic repeats) aiming at editing genomes; CAR-T cell therapy, aiming at detecting and destroying cancer cells etc.
Changing demographics is a complex topic with implications in terms of longevity, mortality and morbidity risks with an increasing focus on healthy ageing. The reduction of birth rates and the progressively ageing population have a significant impact on the economic and financial sustainability of social protection systems and on the competitiveness of the economic-productive system, leading to an increase of defined benefit pensions and changed demand for health care. Demographic changes are intensifying pressures on health systems and are demanding for new directions in the delivery of health care (services).
Operational implications relate to the ageing workforce and the increasing competition between family care and work duties.
The development of global trade, the increasing number of large multinational companies, the growing connectivity and the population expansion have created an increasingly competitive global market.
In a global economic world in which the use of technology, the management of Big Data and Artificial Intelligence are entering into the insurance sector, big players may turn out as new market players in financial markets leveraging on capabilities and skills to manage high technology aspects, big data and artificial intelligence. Fintech (organization, usually in the start-up space, where financial services are delivered through a better experience using digital technologies), techfin (technology firm that finds a better way to deliver financial products as part of a broader offering of services), apps to manage client requirements and similar are expected to improve the efficiency of internal processes and optimize the overall data usage.
The role of companies working in platform may create new ecosystems radically impacting social and economic landscape, as well as financial institutions.
Blockchain is a technology for enabling shared, decentralized databases, which supports multiple writers in "real time", whose entries are verified through embedded trust models, and form one unique transaction log with complete audit trail and opportune applied cryptography. Transactions are grouped into blocks and hashes link the blocks, creating a chain. The hash function creates an encrypted digital output, ensuring that the chain of blocks cannot be modified and can be accessed only by authorized readers.
The blockchain technology was developed in 2008 with Bitcoin as a use case. Since then the technology has been increasingly used in a number of processes, with the purpose to ensure trust, proof and uniqueness in digital transactions without the intermediation of a trusted third party required to manage, facilitate and store historical transactions.
Blockchain represents an important strategic challenge for the insurance industry due to its potential to revolutionize and transform core business processes as well as customer interaction, with a high degree of trust in tracking transactions.


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Sustainability: heating
All office buildings and production halls are heated with heat from their own wood chip heating system. This creates a company internal cycle: the material required for the wood chip heating comes entirely from our own wood processing - meaningful further use of so-called "waste materials" in the sense of sustainability.
Nachhaltigkeit: Electric on the way
Already in 2013, HÖRMANN put its first electric car into operation. Due to the positive experiences, the fleet was extended in June 2018 by another electric vehicle. These serve primarily as a means of transport for short business trips and errands, our employees get these provided for testing. These serve primarily as a means of transport for short business trips and errands, in addition, our employees get these provided for testing. The "refueling" of the electric cars takes place predominantly with own electricity of our solar plants, in addition the company's own electric charging station is also available to customers and business partners, if they arrive with an electric vehicle.
Sustainability: Digital - For the sake of the environment
Together with our in-house IT department, we have developed a company-wide IT system for all departments, which we are constantly optimizing. This should guarantee the exchange of information throughout the company and steadily reduce paper consumption.


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Funny Or Die
Sponsored By
Funny Or Die's Ryan O'Flanagan Visits Mpls., AKA 'Mini Applesauce'Love or hate his comedy, internet funnyman Ryan O'Flanagan's latest video involves a trip to Minneapolis – or "Mini Applesauce, Mini Sodas".
Q&A: Letterman, Sen. Franken Take On Climate Change In New SeriesDavid Letterman and Sen. Al Franken were both feeling frustrated about pessimism around the topic of climate change — so they got together to talk about it.
TTYM: SNL Mocks The NFL, Will Ferrell Mocks Jeter And Giants Co-Owner Mocks The CowboysHere are four sports stories you may have missed this week.


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The UG announces the launch of a new online management system that provides easier access to information pertaining to zoning ordinances, land development regulations and municipal and county codes.
Choosing a business location is one of the most important decisions to make for a small business owner or startup company. EnCode Plus is a new internet cloud-based editing and presentation system that makes it easier for a business to find zoned property that is currently for sale and properties that are available for lease. The user has easy access to sale and leasing documentation on all commercially listed properties in Kansas City, Kansas to help them choose the right property and business location for their purpose.
"Awesome site!," says Scott Warren, who is looking to relocate his business to KCK and is a first user of the UG's new planning and development codes system. "I spent some time poking around this afternoon. Your assistant called me and scheduled a meeting for Thursday with you and George. I'm looking forward to it! See you then."
EnCode Plus is used by many municipalities throughout the country. The Unified Government planners and code writers will now have complete control to…
- Draft
- Edit
- Amend
- Archive
- Codify
- Publish
- And Display
All aspects of our zoning ordinances and code regulations in-house, which improves transparency and reduces the time between an amendment is adopted and then published.
"We are the First community in the Metro Area and one of a handful in the Nation to provide the entire system for our community. I think this will revolutionize how businesses are able to make location decisions within our community with the ability to better inform themselves and make better decisions for their businesses!," says Director of Planning, Rob Richardson.
The Code plays a vital role in the Unified Government's efforts to continue the current economic growth as well as encourage new development and renovation that helps improve the overall quality of life for residents choosing to live in Wyandotte County.
Richardson also emphasizes, "This site follows the Unified government Commission initiative to pursue innovation within our local government."
The user can quickly access the desired information through the new format. Any section of the entire Code of Ordinances can be read by clicking on the View button at the top of the page and navigating to the section using the folders displayed on the interactive right side. You can also search for a particular item by clicking on the Search button. The Favorite Links and Favorite Tables buttons have portions of the Code that are frequently used.
The implementation of EnCode Plus is also part of the government's mission to improve customer service and access to city and county services.
Other additional features also include:
- Historical Archiving
- GIS Interactive mapping
The Maps button provides access to City and County GIS-based map with map layers that include zoning, parcels and Commission districts, and for individual parcels, links to the zoning district regulations and owner/parcel information for the selected property.
The Planning and Development tool ENCODE is now available on the Unified Government's website at www.wycokck.org/planning then selecting the Looking to Start a New Businesslink or at http://online.encodeplus.com/


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Local MP, Caroline Dinenage, today expressed relief that the Public Inquiry into the Stubbington Bypass for the Department for Transport has been concluded. The Inquiry was looking at the Compulsory Purchase of Land Order and the Side Roads Order, further to an objection by a member of the public. Construction of the Stubbington Bypass was due to start early next year but work has now been delayed due to the Inquiry.
The hearing, which lasted two full days, was due to include an important site visit by the Inspector, but the length of proceedings had threatened to delay the visit until the new year. The visit will now take place next Tuesday. Caroline said; "I am pleased that the Inspector has found an opportunity for the site visit and I hope that she is able to complete her report to the Secretary of State as soon as possible to enable a decision to be made, which I hope will be positive, to enable work to begin as soon as possible and save yet more taxpayers money being wasted".
The Bypass scheme involves a package of transport infrastructure improvements including:
- A new 3.5km long single carriageway road that will run south of Fareham and north and east of Stubbington, bypassing the existing B3334 through Stubbington;
- New junctions at either end of the Bypass and at Peak Lane;
- Junction and link improvement works at either end of the bypass on B3334 Titchfield Road and B3334 Gosport Road;
- Supporting highway improvement works in Stubbington village;
- and New / improved / modified facilities for pedestrians and cyclists.
Since becoming elected, Caroline has tirelessly lobbied for this investment and has prioritised tackling road congestion problems in the Gosport constituency. Over the years she has welcomed numerous Transport Ministers to the area to make the case for road investment. In 2016, she held high-level meetings with the Chancellor of the Exchequer and the Secretary of State for Communities and Local Government which helped secure the £19.7m Government funding package for the preliminary bypass work. This secured planning permission and additional road improvements in the Gosport & Fareham area.
In February 2017 the Government confirmed that it would provide the funding necessary to complete the long-awaited Stubbington Bypass. Communities Secretary, Sajid Javid MP, announced the Local Growth Deal allocations to Local Enterprise Partnerships up and down the country. The Solent LEP receiving £31.02 million, providing sufficient funds to build the Stubbington Bypass.
Commenting Caroline said:
"The Inspector heard an over whelming case for the Bypass and the benefits it will provide for the local population in easing our painfully inadequate transport infrastructure and unlocking growth. There were no objections from land owners in respect of the compulsory purchase of the land. Clearly the current B3334 is not fit for purpose and the Bypass will bring about a dramatic improvement in journey times, which will attract more business and employment to the area, particularly to the Daedalus Enterprise Zone. I hope this compelling case, in the public interest is given the 'green light' urgently".
The decision of the Public Inquiry will be announced in due course.


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Giulia and Michele are two Italian expats living in Dubai who decided to visit Beirut over a weekend, and below you will find their experience and perspective on one of the most beautiful cities of the Middle East. You can follow their Beirut and other adventures on Instagram (@TheItalians_SpaghettiAirways).
When we booked our weekend getaway to Beirut we didn't know what to expect. For Dubai expats, Beirut is a party and beach destination, while for others it's just a city synonymous with war and strife. We read a lot before going there, and we knew there was going to be much more than stereotypes.
Our 48 hours in Beirut was an extraordinarily satisfying trip in a city that — despite the cruel past — remains incredibly hedonistic and flourishes with artists, chefs, designers and architects. Boutique hotels are just next to dilapidated houses and stylish bars are right after a tool warehouse. Its beauty is not evident, and not at all classic. It's for those who know how to scratch the surface of things.
And once you find it, you'll love it.
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Beautiful, colorful, dandy streets of Beirut 🇱🇧💕 #theitalians #spaghettiairways • • • #beirut #city #livelovebeirut #streetart #streetstyle #street #urbanart #contemporaryart #streetartofficial #painting #streetphotography #strollingaround #stairs #igtravel #travelling #instatravel #igworldclub #travelstoke #letsgosomewhere #globetrotter #tasteintravel #wonderful_places #mytinyatlas #beautifuldestinations #huntgram #neverstopexploring #weekendgetaway #mydubai
These are just some of the experiences that will tell you why you can't not fall in love with Beirut:
Walking through a unique urban scape: We spent most of our two days strolling around Armenia Street, between Mar Mikhael and Gemmayze. Distressed buildings mix and blend with incredibly beautiful villas and their lush and flowery private gardens. The mash up creates a harsh and striking contrast that captivates and lingers in your mind. That's why here the atmosphere is so vibey and every corner can hide an insta-worthy story – just keep your eyes and mind open!
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Beirut has for sure one of the most peculiar urban scape that we have ever visited. Distressed buildings mix and blends with incredibly beautiful villas, like this one. #theitalians #spaghettiairways • • • #beirut #cityscape #sundaymood #strollingaround #alley #door #villa #peoplescreative #gooutside #letsgosomewhere #stayandwander #weekendvibes #travelgoals #igtravel #travelling #travelphotography #travelgram #instatravel #exploremore #travelstoke #finditliveit #tasteintravel #neverstopexploring #visualsoflife #passionpassport #globetrotter #theglobewanderer #wanderlust
Tucking into the hipster café culture: This made us feeling we are in Europe again! The café scene of this city is worth the ticket itself. Coffee and food are not just in fashion; here we found a movement of young and metropolitan restaurateurs – and caffeine lovers – whose projects are non-mainstream, contemporary and downright cool. Here some names that we want to tip you off:
Papercup is a bookstore with a library-like feel, where bistro tables, majestically made coffee and a bookshelf packed with high end magazines comes together. Get your caffeine fix with the lovely made double espresso, while reading the latest issue of Cereal Mag (the sesame sweet served on the side will give you an extra dose of happiness).
Ginette serves artisanal healthy food in a modernly decorated open space where you can shop trendy home décors and stylish clothes. They do an avocado smash that you will hardly forget.
Urbanista is a cosmopolitan bistro with a funky New York industrial style and a menu that marries Lebanese staples with ingredients and recipes from around the world. Try one of their Urba Roll and Rock — they are incredibly delicious and very healthy at the same time.
Kalei Cofee Co. is a lovely garden café and roastery in a great hidden location deep in the middle of Mar Mikhael. Here you can enjoy freshly brewed coffee hailing from Latin America and Africa, while indulging in a very unique cozy escape.
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Literally blown away by the hipster Cafè culture we discovered in Beirut. Young and metropolitan restaurateurs – and of course caffeine lovers – with contemporary and cool food concept. The Cafè hopping there made us feeling in Europe again.💕 #theitalians #spaghettiairways • • • #coffee #cafe #espresso #morning #goodmorning #morningvibes #breakfast #breakfasttime #igtravel #travelling #foodphotography #coffeegram #travelphotography #travelgram #instatravel #exploremore #forbestravelguide #travelstoke #finditliveit #tasteintravel #coffeelover #wonderful_places #mytinyatlas #passionpassport #globetrotter #theglobewanderer #wanderlust
Visiting a modern art museum "en plaine air": Mar Mikael is home to a growing creative community and the street art movement is one of the most eye-striking and intriguing production from this artist collective. Graffiti is changing the face of the neighborhood and are giving additional momentum to the gentrification process of Armenia street. Artists armed with brushes and paintings are trying to create beauty, improve quality of life by injecting optimism and hope, and shed light on subjects no one talks about.
From decorated staircases to painted building facades, from hidden indie showroom to extemporary vernissage on the street, Beirut artistic epicenter is an open air modern art museum.
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"… this city's secrets, screams and dreams are all embedded in its street art." #theitalians #spaghettiairways • • • #beirut #city #livelovebeirut #streetart #streetstyle #street #urbanart #contemporaryart #streetartofficial #painting #streetphotography #strollingaround #stairs #igtravel #travelling #instatravel #igworldclub #travelstoke #letsgosomewhere #globetrotter #tasteintravel #wonderful_places #mytinyatlas #beautifuldestinations #huntgram #neverstopexploring #weekendgetaway #mydubai
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Awww Beirut… we don't know where to start 😍. You made us fall in love with you in only 48 hours . Few cities are so damn cool in this part of the world. Fact! #theitalians #spaghettiairways • • • #beirut #city #livelovebeirut #streetart #streetstyle #street #urbanart #contemporaryart #streetartofficial #painting #streetphotography #strollingaround #stairs #igtravel #travelling #instatravel #igworldclub #travelstoke #letsgosomewhere #globetrotter #tasteintravel #wonderful_places #mytinyatlas #beautifuldestinations #huntgram #neverstopexploring #weekendgetaway #mydubai
Indulging into lavish food: From tasty street food to contemporary cuisine, the food scene of Beirut has what it takes to satisfy even the most demanding palates. And nothing is more appropriate than the adjective "middle eastern" to describe its cuisine: fresh mediterrean ingredients are married with the zesty character of spices and cooking techniques from the east. This mirrors perfectly the Beirut's vibrant melting pot of cultures.
We found a superb execution of Lebanese cuisine in Liza. This is a high-end restaurant set in a magnificent old villa with stunning interior design inspired by Arabic patterns and decors. But what surprises most is that food is not at all flashy. It's down to earth, hearty and genuinely delicious. Traditional with a little modern twist.
All in all, in only 48 hours Beirut has beaten all the prejudices and exceeded by long distance our expectations. Our minds are still over-stimulated by the amount of colors, flavors, inspirations and perspectives that this city brings out. We cannot wait to go back!
Our suggested itinerary for a weekend getaway in Beirut from Dubai
The good news is that you don't need days off to do all this:
- Land in Beirut on Thursday evening. Both flyfubai and Emirates have convenient late evening flights on Thursday and from Beirut airport it takes only 30 min taxi ride to reach Villa Clara, the hotel at which we stayed.
- Start your day with the delicious breakfast at Villa Clara prepared at perfection by chef Rudy (homemade yogurt and zaatar manoushe are the highlights).
- Walk down Armenia Street to soak up the hipster atmosphere of Mar Mikael. Click your next profile picture at one of the many graffiti decorated staircase. Stop at Papercup for a coffee and some books shopping
- Roam around the neighborhood again and stop for lunch at Urbanista.
- After lunch continue the cafe hopping tour with Sole Insight, sitting on the steps of a staircase where contemporary art pieces are displayed.
- For your afternoon pick me up, stop at Ginette.
- Liza is the perfect choice for your Friday dinner, elegant location and hearty Lebanese food. Looking for a perfect conclusion to this day? Have a Passion Martini on the rooftop of the Junkyard
- On your second day take a short excursion in the morning to Byblos, an old village by the sea just 45 min Uber ride away from Beirut. Spend the morning there visiting the old city center and the historical citadel.
- You will be back in Beirut on time for a late lunch at Kalei Cofee
- Go for some shopping around Mar Mikael, it's the perfect place to find handcrafted décor for the house.
- A late afternoon aperitivo can't get any better than on a rooftop, this time you can try Fabrik.
- Close your tour with a lavish dinner at Villa Clara, french inspired delicacies aren't the best way to end up your 48 hours in Beirut before heading back to the airport.
More about the writers: Giulia and Michele, are Italian inside and out — in their way of enjoying life, searching the beauty of it and making the most. And of course being Italian, they have a big thing for food, pretty big to be honest ;). On top of eating they found the time to travel 48 countries and feed themselves with epic memories. This is how @TheItalians_SpaghettiAirways was born, to share their love for food and travel. Welcome onboard!


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Monday, April 6, 2009
Bunny part two
I finished up my son's bunny this afternoon six days before the holiday. Nothing like cutting it close. Actually, I usually cut it much closer.
I definitely like the pattern better with the heavier fleece fabric. This little guy is so soft and cuddly. Just look at him!
5 comments:
You're SO good at all the things you make! I wish I knew how to read patterns and maybe I could put something cool together.ReplyDelete
It's really not that bad. You should try one that says "simple" of "basic" or something. I never understood them either until I actually used one. Once I swore my way through that first time I figured out what the most essential markings mean, and which ones I could probably forget about.ReplyDelete
- AnonymousApril 8, 2009 at 6:47 AM
How sweet and cuddly...I'm in love...
- AnonymousApril 8, 2009 at 6:49 AM
Hey...that second picture was taken outside, wasn't it...you've got daffodils with buds already! It's still freaking snowing up here!ReplyDelete
Yeah, I have daffodils with buds already. It's 50 degrees three times a week, and then it's in the 30's. I swear it feels like every other day we're hauling the winter coats out of the closet. At least there's no snow, though!ReplyDelete
No more annoying word verification! I do still moderate comments though, so if you don't see yours, I haven't approved it yet! Don't worry, I will!


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Akshay Kumar has finally ended the dull period at the box office as his movie 'Toilet: Ek Prem Katha' has performed exceptionally well in its opening weekend.
The movie has earned a whopping INR 51.45 crore in its opening weekend, making it already a hit.
And if there is one man who is on cloud nine with this news, it is Khiladi Kumar.
The actor could not contain his happiness in a quirky video on social media.
Ranveer Singh shared the video on his Twitter timeline with a caption which reads, "Pressure se mukt ho, apna manoranjan Toilet se karo! #shitguys @akshaykumar #ToiletEkPremKatha."
Pressure se mukt ho, apna manoranjan Toilet se karo! #shitguys @akshaykumar #ToiletEkPremKatha pic.twitter.com/hMTmZgSDJz— Ranveer Singh (@RanveerOfficial) August 14, 2017
In the video, Akshay is seen celebrating the success of his latest film along with Ranveer Singh, as the two are dancing crazily to the song, 'Waqt Hamara Hai', the song from Akshay's 1993 hit 'Waqt Hamara Hai'.
Akshay Kumar too shared on social media with a post, "Toilet ko opening lag gayi, thanks to u all & we can't control our happiness. Big thank u @RanveerOfficial for being the rockstar that u are."
Toilet ko opening lag gayi,thanks to u all & we can't control our happiness😂😂 Big thank u @RanveerOfficial for being the rockstar that u are https://t.co/GVwKkNumPY— Akshay Kumar (@akshaykumar) August 14, 2017
Directed by Shree Narayan Singh and jointly produced by Shital Bhatia, Aruna Bhatia and Prernaa Arora's KriArj Entertainment, 'Toilet: Ek Prem Katha' also stars Bhumi Pednekar in the lead role.


text: Amp reactions Feb 8, 2014 11:20:13 GMT -7 via mobile Quote Select PostDeselect PostLink to PostMemberGive GiftBack to Top Post by JoeMo' on Feb 8, 2014 11:20:13 GMT -7 Just some thoughts here.. In the past, I have talked about how much I can't stand attenuators. After really experimenting with a brake lite a few times I have come up with a conclusion. I really think it's kind of like a stomp box pedal, meaning, I can throw my pedal board in from of a different amp and keep my same settings but it will sound a little different. I kind of get the same thing with an attenuator. It might sound obvious, but I was under the impression that it just reduced volume. It does, but to me it kills some amps and works great with others. To my ears, it's usually the EL-84 based amps that it kind of squashes. I think it works great with amps like the Z28, antidote and remedy.. But for some reason the maz, Zwreck and ghia get squashed. (Not that those amps aren't great)I have tried all these amps with the recommended start in click 4 and go down from there. Idk, just a couple of thoughts. Anybody else hearing the same thing?


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EX to NM condition with "8-10" signatures. Includes: Index Cards - Cliff Drysdale (6), Pancho Gonzalez (6), Don Budge, Chris Evert, Ken Rosewall, Roy Emerson (2), Bobby Riggs (5), Cliff Richey (6), Stan Smith (4), Robert Seguso, Tony Roche (5). 8x10 Photos - Gonzalez, Budge (2 - one VG), Evonne Goolagong. 5x7 Photo - Riggs. Auction LOA from JSA.
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