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In a phase I trial reported in The Lancet Oncology, Burris et al determined the phase II dose of the next-generation PI3Kδ inhibitor umbralisib and found evidence of the agent's activity in relapsed or refractory hematologic malignancies. Umbralisib exhibits improved PI3K isoform selectivity and also inhibits casein kinase-1ε, a regulator of protein translation.
Study Details
In the dose-escalation study, conducted at seven U.S. sites, 90 adult patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma, B-cell and T-cell non-Hodgkin lymphoma, or Hodgkin lymphoma who had received at least 1 previous line of therapy received once-daily oral umbralisib at 50 to 1,800 mg in a fasting state or a micronized formulation at 200 to 1,800 mg in a fed state between January 2013 and January 2016. In August 2014, all patients remaining on study were switched to 800 mg of the micronized formulation.
Adverse Events
Median duration of treatment and follow-up was 133 days. The most common adverse events of any grade were diarrhea (43%), nausea (42%), and fatigue (31%). The most common grade 3 or 4 adverse events were neutropenia (13%), anemia (9%), and thrombocytopenia (7%). Serious adverse events considered at least possibly related to umbralisib occurred in 8%, consisting of pneumonia in 3%, lung infection in 1%, febrile neutropenia in 1%, and colitis in 2%.
The maximum tolerated dose was 1,200 mg of the micronized formulation, and 800 mg of the micronized formulation was selected as the recommended phase II dose. Both cases of colitis occurred at a dose > 800 mg/d.
Response Rates
Overall, objective response was observed in 33 (37%) of the 90 patients, including 17 (85%) of 20 patients with relapsed/refractory chronic lymphocytic leukemia (6 of 8 with high-risk cytogenetic features), and 9 (53%) of 17 with follicular lymphoma. No responses were observed among 8 patients who received the original nonmicronized formulation at a dose < 800 mg/d.
The investigators concluded, "Umbralisib was well tolerated and showed preliminary signs of activity in patients with relapsed or refractory haematological malignancies. The safety profile of umbralisib in this phase I study was distinct from that of other PI3Kδ inhibitors, with fewer occurrences of autoimmune-like toxicities such as colitis. These findings warrant further evaluation of this agent in this setting."
The study was funded by TG Therapeutics.
Owen A. O'Connor, MD, of the Center for Lymphoid Malignancies, Columbia University Medical Center, is the corresponding author for The Lancet Oncology article.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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Support local Scarborough business this weekend.
Businesses along Scarborough esplanade and at the western end of Scarborough Beach Road are suffering as a result of Metropolitan Redevelopment Authority (MRA) upgrading the Scarborough foreshore.
The limited beach access, fences cordoning off areas, and the difficulties with traffic congestion due to works has led to a significant drop in foot traffic.
One popular café […]

subset: commoncrawl


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Thank You for your Valuable orders.
As Part of Preventive Measures against COVID-19 Pandemic there is Lockdown in INDIA. We would like to inform our customers that there Will be Delays in order Processing and Delivery Time. We thank you for your understanding & appreciate that you are with us as we stand with the nation as one determined to fight the pandemic. We would request you to bear with us till then.
Thank You
Vedic Vaani
Kubera Pratima In Copper
Made embossed image made on copper plate.
Dimensions: 1.75 Inches (W) x 2.75 Inches (H) (4 x 6 cms approx)
Kubera pratima in copper plate (Image) is the treasurer of the gods and overlord of the semi-divine Yakshas, the Guhyakas, Kinnaras and Gandharvas, who act as his assistants and protectors of the jewels of the earth, as well as guardians of his city. Kubera is also the guardian of travelers and the giver of wealth to individuals, who please him.
As the treasurer of the riches of the world, Kubera is prescribed to be worshipped. Kubera also credited money to the god Venkateshwara (a form of the god Vishnu) for his marriage with Padmavati. In remembrance of this, the reason devotees go to Tirupati to donate money in Venkateshwara's Hundi ("Donation pot"), is so that he can pay it back to Kubera. Kubera is worshipped with Lakshmi, the goddess of wealth during Diwali, which is primarily dedicated to her.
Design: Made embossed image made on copper plate.
Dimansions: 1.75 Inches (W) x 2.75 Inches (H).
Copper is well known for its grasping capacity. It grasps the divine spirit (sattvikta) upto 30%, when compared to other metals. Copper can destroy bad spirits like Raj & Tam (i.e. darkness & bad behavior). The spiritual vibrations are attracted towards copper items easily. Just as copper has the ability to absorb the sattvik frequencies of deities, it has also capacity of transmitting them. Thus it becomes rich in divinity in a short period.
|Short Description
Made embossed image made on copper plate.
|Show On Homepage
|Created Today
US$ 12 for shipment weighing upto 500 gms applicable for following countries: USA, U.K., Canada, Netherlands, U. A. E., Denmark, Italy, Poland. Belgium, France, Bangladesh, Hungary, Romania, Sweden, Switzerland, Austria, Germany, Spain, Ireland, Slovakia.
US$ 21 for shipment weighing upto 500 gms applicable to rest of the world including: Brazil, Singapore, Malaysia, Thailand, Australia, Congo, Greece, Indonesia, Latvia, Lithuania, Kazakastan, Malta, Mozambique, Norway, Panama, Reunion Island, Russia, South Africa, Taiwan, Trinidad and Tobago.
* For Shipping in India shipments charges Flat Rs. 75 (applicable within India only) .
Cash on Delivery (COD) available within India on Minimum order Value Rs.999.


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WICHITA, Kan. (KSNW) – Wichita East girls' soccer has been dominant all season long, and they made sure that stayed the case today with a 11-0 win over Wichita West.
From the get-go, the Blue Aces were on the attack, sending shot after shot towards the Pioneers' net. It didn't take long for East to break through, and once they did, the goals never stopped.
Wichita East will now host the winner of tomorrow's game between Northwest and Lawrence-Free State on Thursday at 5 p.m.


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This has been a pretty busy year for welcoming back bands and artists who have been important to metal's development over the decades, from Godflesh to At the Gates to former Trouble/current The Skull howler Eric Wagner. We have one more for whom we'll open the iron doors, and they haven't been gone for nearly as long as the aforementioned acts.
Greek black metal stalwarts Varathron last reported to us with a full-length in 2009 with "Stygian Forces of Scorn." And before that, their release schedule was pretty erratic, only putting out two other records in the 16 years prior to that. They're not a prolific band by any means, which probably is why it seems like them returning with "Untrodden Corridors of Hades" seems like such a monumental occasion. The seven-track, 50-minute platter of hatred and evil feels as purely dark as what the band churned out on their 1993 debut "His Majesty at the Swamp." They also serve as a reminder that black metal doesn't have to bludgeon and steamroll, as these guys always have been expert at letting songs breathe and the madness slowly bled out. That remains on this record, which is one of the things that makes it such a damn great listen.
The other part of that is that the band members–longtime vocalist Stefan Necroabyssious, guitarists Sotiris and Achilleas C., bassist Stratos Kountouras, and drummer Haris–are fully engaged and sell this stuff beautifully. Their playing is strong, inspired, and just so heavy, and although the record isn't a perfect document, it's still one of the more memorable black metal albums the last half of the year from a genre where homogenization is choking out creativity ever so slowly. The music here feels evil and doesn't just try to be that way, and as the songs creep into one another, you can feel the danger building as you follow these guys into the fire.
Weird chants and ritualistic thrashing spill out of opener "Kabalistic Invocation of Solomon," which then steers into raw vocals, strange melodies, and a mystical feel that makes it seem like you're ensconced in a fog. There are sheets of synth that drop, strong lead guitar playing, and a calculated pace designed to stretch out the drama. "Realm of Obscure" marches heavily out of the gates, with strong riffs and a gallop that smothers you. The drums are absolutely assaulted, with complex guitar work unfurling and savage vocals feeling monstrous and growly. The guitars stab methodically, and the composition ends in fiery glory. "Arcane Conjuring" feels machine-like at the start, with Necroabyssious' vocals sounding wonderfully deranged and murky, with odd melodies lurking behind. The pace settles a bit, with wild birds cawing and chant-like growls darkening the mood before it fades out in a mid-tempo drubbing.
"Leprocious Lord" has feral growls that sound raw and animalistic, guitar work that tricks and twists, and a sturdy bassline that buzzes through the middle. The vocals sound like they're reaching into the spirit world, while the rest of the band builds an oppressive fever of chaos and unleashes some really intriguing progressions. "The Bright Trapezium" is the one sticking point on the record for me. It feels like four different songs smooshed together, and it never really gets off the ground, switching personalities just when things seem to be settling into place. There are some nice gothic flourishes and tasty guitar work here, but the whole thing falls a little flat. Luckily, we pick up on "Death Chant" that has an eerie, chilling first half, with guitars shredding flesh and Necroabyssious' vocals sounding noxious and dangerous. Atmospheric synth later rises up, providing imposing shadows to the ominous storytelling, and the track ends with a crushing gasp. Closer "Delve Into the Past" rips open, throwing speedy guitars, fearsome vocals, and neck-snapping tempo shifts your way. The song is massively destructive, a great final salvo for the band to blacken your eyes and bloody your mouth, whipping everything into a tornadic bloodshed before dragging you to a tumultuous end.
I know I've said this a bunch of times about the other really quality late-year records that have come at us like a tidal wave, but I wonder how much more end-of-year enthusiasm would surround "Untrodden Corridors of Hades" if Varathron had released it, say, over the summer. Nonetheless, it's a great record, a really volcanic ride, and one that takes its time setting the stage to let the horrors play out in front of you. It's awesome to have Varathron back in our consciousness to make great noise again. We probably won't hear from them again for a while, so make sure you relish this while it's fresh.
For more on the band, go here: http://www.varathron.com/
To buy the album, go here: https://www.agoniarecords.com/index.php?pos=shop&lang=en
For more on the label, go here: https://www.agoniarecords.com/


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2 Tbsp. butter or margarine
1.5 cups Alberta Lamb strips, 2 x ¼ x ¼"
small onion, sliced and separated into rings
½ can (8 oz.) water chestnuts, sliced
¾ cups water
1 Tbsp soy sauce
1 Tbsp cornstarch
¾ tsp. instant beef bouillon
½ tsp. salt
1 package (6 oz.) frozen pea pods
Hot cooked rice or chow mein noodles
- Melt butter in 8" skillet; cook and stir meat and onion over medium heat until lamb is brown and onion is tender.
- Add remaining ingredients, except pea pods and rice. Heat to boiling, stirring occasionally. Add pea pods; cover and simmer 5 minutes.
- Serve on rice or noodles.
Recipe courtesy of Janine McMillan


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If you are an attorney, you know how important time management is. Facing the potential of a 12-to-16-hour day every day will eventually catch up to you, impacting your health, wealth and happiness. Learning how to manage your time effectively will help you work smarter, not harder. With that in mind, here are some handy time-management tips that you can put into practice today, so you can get back to having a life:
- Be your own personal assistant: organize your tasks.
Don't fly by the seat of your pants. Start your day by making a list of what needs to be done. That way you're not wasting time wondering what to do next. Include things that must be done today as well as long-range tasks. Don't waste time on things you don't have to think about, or things your staff can handle. Make your list while you're having your coffee each morning. It takes no time at all, and you'll have the tools you need to stay focused and carry on.
- Break your list into segments
Look at everything on your list, and make note of the things that you absolutely must handle yourself. As for the rest, delegate, hand-off, and outsource. Even if you're one of those perfectionists who tend to think that nobody can do what you do, try to humble yourself for a moment, and realize that some things can be accomplished just as well by somebody else. Or if you have a hard time being humble, consider that you might be far too important to be handling trivial tasks, and let it go.
- Get some exercise
Exercise not only pumps up your energy and keeps you going longer, but it is good for the heart and your mind as well. Being stuck behind a desk isn't doing you any justice, and the long-term negative effects might actually be causing you harm. If possible, move about as you work. Take phone calls while you are walking, or turn a meeting into a walk-and-talk. You'll be making the most out of your time and getting in some exercise and fresh scenery at the same time. It's also never a bad idea to invest in a standing desk or vari-desk so that you aren't rooted to one place all day.
- Consider hiring a free-lancer or a temp
Even if your budget does not allow for a full-time support staff, there are plenty of part-time options out there to help you get the job done. This could be a contract attorney, or a temporary legal assistant or paralegal. You might also consider hiring a virtual paralegal, most of whom work on an hourly or project basis.
- Stop worrying about money
It's easy to get distracted by the competition. Do yourself a favor – stop focusing on what others are doing and get back to work. That's where the money is going to come from, in the end. If you set realistic targets, follow a sound business development plan, and maximize the time you spend on work related tasks, results will follow – and so will the income.


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The roof is the highest part of a house. It usually protects what is beneath. The roof makes sure that people can live comfortably while also shielding the interior parts of the house from water. Nevertheless, people fail to maintain their roofs accordingly. As a result, the roofs will deteriorate because of lack of maintenance. If a roof is not maintained properly, it may fail to achieve its maximum life span. The lifespan of a roof is determined by different factors. However, if you have any roof problems, it is advisable to contact a roofing contractor.
One of the reasons why people look for roofing contractors is because they need repair or replacement services. When looking for a roofing contractor or company, always make sure that the contractors will be able to meet your needs. After the repair services are complete, the lifespan of your roof will be prolonged. As a result, it is good to heed to the following tips when hiring a roofing contractor:
Make Sure They Have A Local Physical Office
The contractor must have a physical office within the locality they are offering their services. In case you have an issue, you can visit them conveniently. At first, the contractor must issue a physical address where you can visit them. You will be in a better position to confirm whether they have staff members as well as other things. If they are hesitant to provide a physical address, you can move on.
Look For Multiple Quotations
It is advisable to get at least three bids/ quotes when looking for some metal roofing supplies florida. Every roofing contractor will have a different quote, and their labor costs will also differ. For starters, a homeowner will avoid being overcharged since they will have a rough estimate of the labor costs depending on whether they are seeking repair or maintenance services. At the end of it all, the homeowner will get value for their money.
The Contractor Should Provide References
When you ask for references, you will be in a better position to learn more about whether the roofing contractor is experienced. Additionally, the samples will help you to gauge the quality of their work. Some contractors include their samples on their websites. Such samples come in handy since a prospective client can easily view their portfolio. The references should be in the form of a list that has the contact details of previous clients. Contact each client and ask them different questions such as whether they were satisfied with the services offered by the roofing contractor. Also, you can ask about their work ethics.
The Presence of An Insurance And A License
A roofing contractor should be insured and licensed. Licensed contractors will always appear to be trustworthy since they have undergone different tests before being issued a license. They will also perform their duties professionally. A licensed contractor will always have an insurance policy since they have to be compliant regarding the different requirements that are present in the roofing industry. If they get injured while offering repair or maintenance services, the insurance company will compensate them.


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Military Training.ca
Military Training
Secret Service
Sea Operations
A Disciplined Soldier
You will be expected to become quickly amenable both mentally and
physically to discipline. A clear conception on your part of what drills
are disciplinary in character and what discipline really is, will help
you to become a disciplined soldier. Drills executed at attention are
disciplinary exercises and are designed to teach precise and soldierly
movements and to inculcate that prompt and subconscious obedience which
is essential to proper military control. Hence, all corrections should
be given and received in an impersonal manner. Never forget that you
lose your identity as an individual when you step into ranks; you then
become merely a unit of a mass. As soon as you obey properly, promptly,
and, at times, unconsciously, the commands of your officers, as soon as
you can cheerfully give up pleasures and personal privileges that
conflict with the new order of life to which you have submitted, you
will then have become a disciplined man.
1st Exercise
A Final Word
1st Exercise
A Disciplined Soldier
A Final Word
A Model Order For An Advance
Advance Cavalry
Advance Guard Of A Small Command
Advance Guards
Advancing The Attack
Advantages And Disadvantages Of The Defensive
Advantages Of The Attack
Advice Regarding Habits
Advice To Officers
Appearance Of Objects
Arm Signals
Army Slang
Articles Of War
Assumption Of The Enemy
Attack And Defense


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Tag: early childhood music classes
Winter Session II Open for Registration With NEW Enrollment System
Hello new and current Sprouting Melodies Families! We are pleased to announce that our Winter Session II Sprouting Melodies classes are open for enrollment. This session begins February 16 and ends March 28. Our EARLY ...
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This was shared on a mailring and it is so true! I'm thrilled to add that my first week of school was great. My students seem to be a great bunch.
1. You can hear 25 voices behind you and know exactly which one belongs to the child out of line.
2. You get a secret thrill out of laminating something.
3. You walk into a store and hear the words "It's Ms/Mr. _________" and know you have been spotted.
4. You have 25 people that accidentally call you mom/dad at one time or another.
5. You can eat a multi-course meal in under twenty-five minutes.
6. You've trained yourself to go to the bathroom at two distinct times of the day: lunch and conference period.
7. You start saving other people's trash, because most likely, you can use that toilet paper tube or plastic butter tub for something in the classroom.
8. You believe the teachers' lounge should be equipped with a margarita machine.
9. You want to slap the next person who says "Must be nice to work 7:15 to 3:15 and have summers off".
10. You believe chocolate is a food group.
11. You can tell if it's a full moon without ever looking outside.
12. You believe that unspeakable evils will befall you if anyone says "Boy, the kids sure are mellow today."
13. You feel the urge to talk to strange children and correct their behavior when you are out in public.
14. You think caffeine should be available in intravenous form.
15. You spend more money on school stuff than you do on your own children.
16. You can't pass the school supply aisle without getting at least one thing!
17. You ask your friends if the left hand turn he just made was a "good choice or a bad choice."
18. You find true beauty in a can full of perfectly sharpened pencils
19. You are secretly addicted to hand sanitizer.
20. You understand instantaneously why a child behaves a certain wayafter meeting his or her parents.
Sunday, September 9, 2007
How Do You Know You are a Teacher?
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View across the exhibition
This exhibition staged at the Thoresby Gallery
by Oakwood Ceramics featured the work of Cornish potter Peter
Swanson. A range of ash glazed stoneware was exhibited alongside
a small number of pots from Peter's wood fired anagama kiln.
Peter's pottery is in Rosudgeon near Penzance.
He also produces a range of ash glazed tableware which I can highly


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It is hard to imagine how anyone could be more insulting to a person than to attack his mother. And yet, it seems attacks on the Virgin Mary are not only fashionable today, but the rage! A new play on Broadway described here:
Toibin's daring take on the life of Virgin Mary wows critics in US
who spoke to Lucia saying, "Have pity on the Heart of your Most Holy Mother. It is covered with thorns with which ungrateful men pierce it at every moment, and there is no one to remove them with an act of reparation." Then Our Lady spoke, "See, my daughter, my Heart encircled by thorns with which ungrateful men pierce it at every moment by their blasphemies and ingratitude. Do you, at least, strive to console me. Tell them that I promise to assist at the hour of death with the graces necessary for salvation all those who, in order to make reparation to me, on the First Saturday of five successive months, go to confession, receive Holy Communion, say five decades of the rosary, and keep me company for a quarter of an hour, meditating on the fifteen mysteries of the Rosary."
Virgin most sorrowful, pray for us!


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Children's Wall Stickers
Here at bobo kids we offer a large selection of children's wall stickers and decorations suitable for bedrooms, playrooms or any area of the house. Kids' wall stickers act as a genuine alternative to wallpaper and from fun characters to landscapes and creative objects, bobo kids has something to suit everyone.
Create Magical & Exciting Worlds on Your Walls
Take a look through this delightful range and you will be able to see the kind of fun and creative worlds that are opened up by bringing kids' wall stickers into the mix when designing rooms for your children. The great thing about this range is that you will be able to ensure that the design you choose links up perfectly with your kids' favourite interests! With this vast collection offering animals, balloons, feathers, boats and much else besides, they give you the perfect chance to personalise your children's rooms.
Fun & Charming
The quality of these children's wall stickers is testament to how much these brands really do care about parents and their kids. We feel that the good people of Mimi Lou, Chipsum and Studio Ditte are some of the most creative and all in all impressive in the business, and this shines through in the charming, vivid and characterful stickers in this collection. Whether you are looking for a small children's wall sticker to accessorise a dull corner or looking for a large kids' wall sticker to fill a whole wall as a fantastic eye-catching feature, we hope you'll be delighted with our selections.


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HAULER 800GX E-Z-GO Golf Cart
Fully loaded and ready to work.
The Hauler™ won't back down or balk when it's time to get to work. You get a best-in-class 13-hp Kawasaki® gas-powered engine 48-volt electric drivetrain and capacities from 800 to 1200 lb. And, the optional limited slip differential delivers better traction with less turf damage in wet or uneven terrain. So get a Hauler and get after it.
- Gas drivetrain
- Roto-molded polyethylene or optional aluminum cargo bed
- Optional limited slip differential
Standard Features
- Turf Tires: Provide excellent stability without damaging turf
- Headlights: Safely navigate in any lighting condition
- Roto-Molded Polyethylene Cargo Bed: Durable construction for even the toughest jobs
- Bench Seating: Comfortable, spacious seating for passengers
- Optional Locking Glove Box: Safe and secure onboard storage
- Front Bumper and Brush Guard: Added vehicle protection and durability
Download the HAULER 800GX E-Z-GO Golf Cart Brochure
FREEDOM TXT Gas SPECS
|Overall Length
|107 in (272 cm)
|Overall Width
|49.5 in (128 cm)
|Overall Height (No Canopy)
|46.5 in (118 cm) (Top of steering wheel)
|Overall Height (With Canopy)
|70.0 in (178 cm)
|Wheel Base
|65.5 in (166 cm)
|Front Wheel Track
|37.0 in (94 cm)
|Rear Wheel Track
|38.0 in (97 cm)
|Ground Clearance @ Differential
|4.3 in (11 cm)
|Cargo Box Width (Inside)
|44.5 in (113 cm)
|Cargo Box Length (Inside)
|30.5 in (77 cm)
|Cargo Box Depth (Inside)
|7.5 in (19 cm)
|Cargo Box Capacity
|5.9 cu ft (0.17 m³)
|Cargo Box Material
|Roto-molded polyethylene
Vehicle Power
|Power Source
|4 Cycle 24.5 cu in (401 cc)
|Valve Train
|Single Cylinder OHV
|13.5 hp (10.1 kW) Exceeds SAE J1940 Standard
|Electrical System
|Starter/Generator. Solid State Regulator
|Batteries (Qty, Type)
|One, 12-Volt Maintenance Free
|Key or Pedal Start
|Air Cleaner
|Industrial Rated Dry Filter
|Pressurized Oil System
|Oil Filter
|Cooling System
|Air Cooled
|Fuel Capacity
|6.0 Gallon (22.7 L) Tank
|Continuously Variable Transmission (CVT)
|Differential with helical gears
|Gear Selection
|Rear Axle Ratio
|11.42:1 (Forward), 15.78:1 (Reverse)
|Seating Capacity
|2 Persons
|Dry Weight
|750 lb (340 kg)
|Curb Weight
|895 lb (406 kg)
|Bed Load Capacity
|500 lb (226 kg)
|Vehicle Load Capacity
|800 lb (360 kg)
|Outside Clearance Circle
|18.9 ft (5.76 m)
|Intersecting Aisle Clearance
|Speed (Forward)
|14.0 mph ± 0.5 mph (22.5 kph ± 0.8 kph)
|Speed (Reverse)
|12.3 mph ± 0.5 mph (19.8 kph ± 0.8 kph)
|Towing Capacity
|720 lb (327 kg) max load
Steering and Suspension
|Self-Compensating Reduction Rack and Pinion
|Front Suspension
|Leaf Springs with Hydraulic Shock Absorbers
|Rear Suspension
|Leaf Springs with Hydraulic Shock Absorbers
|Service Brake
|Rear Wheel Mechanical Self-Adjusting Drum
|Parking Brake
|Self-Compensating, Single Point Engagement
|Front Tires
|Links 18 x 8.50 – 8 (4 Ply Rated)
|Rear Tires
|Turf Saver 20 x 10 – 10 (Load Range B)
Body & Chassis
|Welded Steel with powder coat
|Front Body and Finish
|Injection-Molded TPO
|Rear Body and Finish
|Steel. Base Coat/Clear Coat
|Standard Color
|Forest Green
Interested in the HAULER 800GX?
Willowbrook Utility Vehicles – Houston Golf Cart Sales and Rentals has the best pricing in Southeast Texas on new HAULER 800GX, pre-owned HAULER 800GX models, and HAULER 800GX rentals. Contact one of our Sales Managers at (832) 237-8333 or fill out the information below, and one of our golf cart specialist will be in contact shortly.


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The Boyue Likebook Mars and Kobo Forma are two e-readers that have both been released in the past few weeks. They run vastly different operating systems and the hardware specs warrant your attention. If you are a serious reader, what device is ideal?
The Likebook Mars features a 7.8 inch E Ink Carta touchscreen display with a resolution of 1782×1448 and 300 PPI. Underneath the hood is a 8 core 1.5 GHZ processor with 2GB of RAM and 16GB of internal storage. This is the first e-reader ever made with an octa-core processor. It also has support for Bluetooth, WIFi, 3.5mm headphone jack, but doesn't have built in in speakers.
The Mars has a SD card, something many companies seem to be forgoing. Kobo no longer includes an SD card in any of their e-readers and ditto with the Kindle. Even Onyx Boox has decided to not include expandable storage to any of their higher priced Note e-readers. Mars supports a 128GB SD Card or anywhere in between. It also has Android 6.0 and Google Play to access a myriad of apps.
The Kobo Forma features an 8 inch display that uses E Ink Mobius and Carta HD and has a resolution of 1440 × 1920 and 300 PPI. It is powered by a Freescale IMX6 Solo Lite 1GHZ processor and 512MB of RAM. The 8GB storage model will be the most accessible, there is a 32GB version, but it will only launch in Japan, for now. The Forma also does not have an SD card. Kobo employs Linux on their e-readers, which is more stable than Android.
Both of these devices have a color temperature system and a front-lit display. They both have 17 LED lights with a mixture of white and red. The intention behind this new display is to help mute the bright white screen into various degrees of orange.
One of the advantages of the Kobo e-reader is that it has a gyroscope and manual page turn keys. It also has Overdrive functionality built into the firmware, so the entire experience is very robust. The Likebook has amazing hardware, but the Android experience is buggy.
The Likebook Mars retails for $259 and is available on the Good e-Reader Store. Kobo Forma, with 8GB of storage, will be available in black and will retail for $299.99 CAD, $279.99 USD, 279.99 Euro and 239.99 GBP at select retailers and at www.kobo.com. Pre-orders begin October 16, and as of October 23, Kobo Forma will be available in stores and online in Canada, the US, the UK, Italy, the Netherlands, France, Japan, and Spain; and as of October 30 in Australia, New Zealand, Switzerland, Sweden, and Turkey; early 2019 in Mexico. Kobo Forma with 32GB of storage will be available in Japan October 23, and will be available in other countries at a later date.
Michael Kozlowski is the Editor in Chief of Good e-Reader. He has been writing about audiobooks and e-readers for the past ten years. His articles have been picked up by major and local news sources and websites such as the CBC, CNET, Engadget, Huffington Post and the New York Times.


text: Resources Prayers This Week in Prayer: Yemen Feba UK partners in the Yemen Project are supporting the production, broadcast and follow up of programmes. The broadcasts help listeners consider social and spiritual change, and bring practical advice as well as teaching about the Christian faith. The Yemen Project team is running a campaign this year on radio and social media, targeting young Yemeni women who are struggling with their personal value. TUESDAY 1st October At the start of the new school year in Yemen, many schools have either been destroyed or badly damaged during the civil war that has ravaged this country since 2015. With few teachers remaining in the profession, please pray that God will give them the strength to persevere and the wisdom to teach and inspire children and young people to work towards a future where they can learn and grow up in peace. WEDNESDAY 2nd October Praise God for the many responses the Yemen Project has received this year to their campaign on radio and social media speaking directly to Yemeni women. Please pray for the team as they continue to nurture and disciple these women, many of whom are asking deep questions about faith. May they come to believe in Jesus and know how much he loves and values each one of them. THURSDAY 3rd October Please pray for God's spiritual armour and protection over our Christian brothers and sisters in Yemen. Tensions are rising in the region following the recent attacks on Saudi Arabia's oil facilities. And with no end in sight to Yemen's civil war, it's become extremely difficult and dangerous for Christians to meet and attend church in each other's homes. FRIDAY 4th October We thank God for three men and a woman who have recently committed their lives to Jesus after hearing the good news on radio. Please pray for members of the Yemen Project team as they teach and disciple these new converts before they take the next step and connect them with a local church. SATURDAY 5th October Our partners in Yemen have asked us to pray specifically for healing for a woman known as 'QR' who has blood cancer. This woman is searching for God and is very close to accepting Jesus as her Lord. The team in Yemen has been in contact with her for over two years. Please pray that God would answer her cries for help and heal her in Jesus' Name. If you would like to receive Prayer Focus by email monthly, please contact us. The same material is also available on the PrayerMate app.


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A Road Rally is basically a large-scale scavenger hunt. You gather a team of up to six amazing people. With your team, you will drive around following a set of instructions and find the answers to a set of clues and questions that we provide for you. Throughout the route, you will be required to complete other tasks as well. At the end we will all meetup, share stories, have a drink and order some food. The team that completes the most tasks and receives the most points in the least amount of time will also win some cash! You can expect to have a blast.
- Road Rally- April 27, 2019
- Starts promptly @ 6:00 PM
- Costs: $25 per person
- Deadline to sign up April 8, 2019
- Link to 2019 Road Rally Flyer


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by The Associated Press, August 25, 2016
PARIS (AP) — The mayors of London and Paris are criticizing local French bans of body-covering burkini swimsuits, saying women should wear what they want to the beach.
Burkini bans in several French coastal towns this summer have prompted a debate in France and outrage among many people abroad.
London Mayor Sadiq Khan, the city's first Muslim mayor, said during a visit to Paris on Thursday, "I appreciate that there is a state of emergency in France." But he added "I don't think anybody should be telling women what they can or what they can't wear."
Paris Mayor Anne Hidalgo called for an end to burkini "hysteria," saying authorities should instead focus on improving social cohesion.
Proponents of the bans argue that burkinis represent the servitude of women and violate France's secular policies.
This article was from The Associated Press and was legally licensed through the NewsCred publisher network.


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Uma das novidades mais ressonante dos últimos dias é a descoberta de uma nova classe de vulnerabilidade em MDS (Amostragem microarquitetura de dados).Eut is peculiar that owners of PCs, equipado com competindo com processadores AMD Inter, estão fora de risco; produtor confirmou que seu produto não é afetado por novas vulnerabilidades.
Leia sobre isso em nosso artigo: Zombieload e companhia: pesquisador descobriu nova classe de vulnerabilidades em processadores Intel
Concerning Intel, it seems like experts were mistaken when thought that after story with Fusão e Spectre vulnerabilities they cannot be surprised. New scandal continues to gain momentum and recently was investigated that Intel allegedly tried to get more time and buy silence of researchers from Amsterdam Universidade Livre that found new vulnerabilities in Intel processors.
"Intel offered to pay the researchers a $40,000 "reward" to allegedly get them to downplay the severity of the vulnerability, and backed their offer with an additional $80,000. The team politely refused both offers", — Dutch publication Nieuwe Rotterdamsche Courant reports.
The case is obligatory condition of remuneration payments in Intel is signing standard non-disclosure agreement on confidential information. assim, if proposition is accepted, researchers oblige to be silent about vulnerabilities and discussing this top-secret information with the narrow circle of authorized employees.
In Intel explain such approach by the necessity of allocating time on investigation of issues and development of respective patches while disclosing of data prior to these interventions increases risk that attackers will use gaps before than they will be closed.
Researchers allegedly were not satisfied by this variant and they decided to refuse from reward to be able to share information about vulnerabilities and related risks with the public.
And here it all fits: updates of processors' microcodes and relevant patches from vulnerabilities for different software just started to deploy for susceptible devices to a new class.
Fonte: https://www.techpowerup.com


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Just wondering if you guys have started to let creators know if they are in or not. , or are ou guys still deciding?
I doubt they'll be able to provide answers/feedback with so many entries ( I think they said around 200?).
But yeah, it would be super nice if they could reply with feedback- is more art needed? was the story summary too slow? was it perfect but it just needs to be resubmitted in the winter because too much competition? etc. All stuff I'd be curious to know if I didn't get accepted.
Every time I see an email from tapas, I get heart palpitations thinking it's for incubator (it raced embarrassingly quick when I got this notification), haha. But I was specifically asking if the participants can contact the staff for feedback rather than the other way around (I know it'd be asking a lot for them to contact us).
Hahaha, I'm so sorry my notification raised your hopes. I too am watching my inbox like a hawk. Yeah, I meant even if participants were allowed to do so- because there's so many it'll be hard on Tapas staff. Even if they answered 50/100 then people might get upset they didn't get an answer when others did.
That said, unless they specify otherwise, I'll prob still shoot them an email. Don't know til you try right?
So thats like only a week left till August, I am assuming they already picked and notified the winners. Next time better luck maybe!
Have the announcements for the submissions last month been posted somewhere I'm not aware of? I'm so excited to hear who the winners are Also, is it winners? or is it just one person this time around?
thanks for the great opportunity, Tap! looking forward to hearing more about how this round went!
They'll announce winners in august.
But with 4 days left I think people who haven't heard anything didn't make it? Is it safe to post our new comics online yet?
Lol, this is what I think also.
@staff can we get a confirmation? <3
Does anyone know when the next incubator program will be announced?
They said it would have another submission opening in the winter so I'm predicting late november/mid-December.
can I post the concept art on social media that I submitted?
Where are the winners?
Considering it JUST turned August, I doubt we'll be hearing about the winners anytime soon ( I'm sure the winners still have to look over their contracts). I do hope, though, that we here something from the staff soon.
I thought they were going to be announced on 1st August
Still hoping for that email confirmation,even though its 10th August already! Please announce the result and put the rest of us out of misery
They said they wanted to give people time to look over the contracts, which I think is a very good thing. They probably don't want to announce anything until they're sure exactly who's on board.
Yep! Because anyone who doesn't want to go through with the contract even after negotiations, Tap will most likely contact any runner-ups to fill their spot.
Is there any update? :o
Lol at this point, I'm just wondering if I should contact Tapas staff and ask how I can improve my entry for the winter round :''''')
August is ending soon, though, so hopefully there will be SOMETHING posted.


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Mission Beach Retreats
Tap into vitality with these 3 night retreats at Mission Beach, North Queensland.
Join Jen as she leads you into the nourishing and uplifting atmosphere of a three day yoga retreat. Jen's retreats are a wonderful opportunity to rest, recharge, explore deep within and share in the company of inspiring like minded people.
Enjoy a morning juicy Vinyasa Flow practices that will awaken your body and mind and leave you feeling relaxed and strong. The evenings will be sweet and blissful Restorative Yoga and Meditations.
Retreats with Jen will break you out of the same old box, revealing new territory in the body, mind and heart inspiring a dedication to living authentically, courageously and joyfully.
Jen is known for her warm and approachable style of facilitating that encourages self inquiry through curiosity, courage through vulnerability, playfulness and creativity through movement. You will leave this retreat connected, inspired, cleansed and restored.


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Ready To Start Your Investing Journey The Right Way?
Is It Possible To Go From Investorphobe To Successful Investor In Just 10 Days?
I know what you're thinking...10 days to become a successful investor...that's not possible.
Sure, lots of gurus and finiancial experts will tell you it takes years to learn how to invest and years to be successful at it and unfortunately you have believed this mantra as you've heard it so often.
I want you to forget what you've been told because it's wrong.
You can absolutely learn how to successfully invest in 10 days and I will show you how!
Is This Course For Me?
This is the question I often get asked. You've been watching youtube videos and keeping an eye on the news. You can see the power of investing but don't know where to start.
Unfortunately we are all told how difficult the stock market is and how unpredictable it is. I've even heard professionals refer to investing as gambling.
With all this happening, it's no wonder people that talk to me don't think they're ready to step up, back themselves and start investing.
The simple answer is this, investing is for everybody. I mean it, it doesnt matter if you're young or old, if you have lots of money or a small amount of savings.
If you want to make your money work for you to earn more money then investing is the way to do it. So, if you're serious about increasing your wealth there i no better time than now to get into investing.
What Are The Benefits Of This Training?
Our 10 Day Rookie Investor Challenge will teach you how to be a successful investor in 10 days....that's it. It's for everybody and has the following benefits:
- Detailed Video Training Over 10 Days
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Glenn H. Naeve - 76
3/28/1941 - 2/20/2018
Andover, Iowa
Glenn H. Naeve, age 76 of Andover, passed away Tuesday, February 20, 2018 at Mercy Medical Center North. In following Glenn's wishes a private family service will be held. Burial will be in Andover Cemetery. Casket bearers will be Daniel Heiar, Ben Daehler, Zach Hudson, Kipp Ketelsen, Jeff Naeve and Dale Kruse. The Pape Funeral Home, Clinton is assisting the family. Glenn was born in Clinton on March 28, 1941, the son of Reynold and Malinda (Schroeder) Naeve. He married Diane Determan on May 28, 1960 in Clinton. Glenn owned and operated Andover Grain and Fertilizer. He had served as Mayor of Andover for many years. He was a member of Faith Lutheran Church, Andover and the Andover Fire Department where he also was an EMT with the ambulance service. He enjoyed fishing, golfing, woodworking and vacationing with his family. Glenn is survived by his wife Diane; three children, Patti (Kevin) Diercks of Andover, Dan "Boone" (Marla) Naeve of Clinton and Lynn (Paul) Heiar of Charlotte; five grandchildren, Jennifer Diercks, Kelli (Ben) Daehler, Allyson Naeve, Breanne (Zach) Hudson and Daniel Heiar; three great grandchildren, Cael and Cade Hudson and Brooklyn Daehler; two brothers, Robert (Janeen) Naeve of Andover and Raymond (Ronda) Naeve of Andover; a sister Linda Bousman of Clinton and nieces and nephews, He was preceded in death by his parents, a niece Rae Ann Naeve and his two four legged friends, Rufus and Matty. Online condolences may be left at www.papefh.com.
In following Glenn's wishes a private family service will be held. Burial will be in Andover Cemetery.
In following Glenn's wishes a private family service will be held. Burial will be in Andover Cemetery.View Glenn H. Naeve's Guestbook
Recent Obituaries
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Cranberry Compote
Total TimePrep/Total Time: 25 min.
Makes6 cups
- 2 medium tart apples, peeled and sliced
- 1 package (12 ounces) fresh or frozen cranberries
- 1-1/4 cups sugar
- 1 cup golden raisins
- 1/4 cup orange juice
- 1 teaspoon grated orange zest
- 1 teaspoon salt
- 1/4 teaspoon ground allspice
- 1/4 teaspoon ground cinnamon
- 1 can (15-1/4 ounces) sliced peaches, drained
- 1 can (15 ounces) apricot halves, drained
- 1 cup chopped pecans
- In a saucepan, combine the first nine ingredients. Bring to a boil. Reduce heat; simmer, uncovered, for 10 minutes or until cranberries pop and apples are tender. Add the peaches and apricots; heat through. Stir in pecans; serve warm or chilled. Store in the refrigerator.
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Nov 1, 2017
I've used this recipe since 2003. It's great tasting and also makes the house smell wonderful. Adults love it. Children are more picky about it.
Nov 24, 2015
I have been making this recipe for holiday dinners since it was published 15 years ago.Everyone loves it. It is fast, easy, and makes the house smell wonderful not to mention it is delicious. There is NO reason for canned cranberry sauce EVER again!
Nov 19, 2015
This became my all-time favorite several years ago. I absolutely love to make this for this time of year. The canned fruits are easily substituted so you can use what you might have on hand. Pears work nicely.
Nov 26, 2013
I made this last year and it instantly became a family favorite!
Jan 25, 2013
No comment left
Nov 30, 2012
My mother-n-law loved this! It has an old fashioned flavor similar to canned spiced apples only better.
Oct 9, 2012
I first made this recipe over 10 years ago, and it is still a hit. I am ask to make it every Thanksgiving. I always omit the orange peel because to me it has a bitter taste.
Oct 29, 2011
This recipe has become a tradition for my family at Thanksgiving. The kids say, "what is compote"? It is stewed fruit. Thanksgiving seems like one should serve some cranberry dish...and this is it! The kitchen smells wonderful as this cooks on the stove and it is good warm or cold!
Jan 18, 2011
Wonderful Flavor! I did make a few changes though..I was out of orange juice so I used cherry juice, & I did not have golden raisins so I used dried currents! Very happy with the way this turned out!
Jan 24, 2010


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We still have some citrus stashed away in our freezer from our trip to Cali. When we couldn't use it all right away, I spent an afternoon juicing and zesting so that none of it would end up going bad.
That zest and juice is perfect for these brown butter citrus pancakes on a lazy weekend morning. They were a hit with the hubs. The light, bright flavor of the citrus really makes something as simple as a pancake shine (and feel less heavy).


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Without love - nothing!
'If I do not have love', Paul wrote to the Christians in Corinth, 'I am nothing' (1 Corinthians 13.2). He did not view its acquisition as an optional activity but the bedrock foundation of the Christian life — an absolute necessity. Not surprisingly, when he is describing what the transforming power of the Holy Spirit will look like in practice, he lists a string of qualities which each depend on and flow out of the greatest characteristic of godliness — love.
Chief manifestation
Take a moment to think about this pen-portrait of the growing Christian, from Galatians 5.22-23. 'The fruit of the Spirit is love, joy, peace, patience, kindness, goodness faithfulness, gentleness and self-control.' At first, this might look like a string of pearls, or a collection of different qualities needing to be added separately to our character. But the best way to understand the verse is perhaps to recognise 'the fruit of the Spirit is love' — and the way that love will manifest itself is in the joy, peace, patience and so on, which are its expression in our daily lives and relationships, first with God, then with one another in God's family and with the watching world.


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צפיות 3297
This script is designed for those who want to use BitMex's trailing stop. It's not meant to be used as entry exits, but rather to get an idea of how wide the trailing stop needs to be. I suggest you backtest with different values. The script can also be integrated into an existing strategy which does give entry/exits to act as its stop loss.
Can you explain how to put this to backtest further back in time- when I load it, it only shows trailing for the last 2 weeks?
@ippp0031, the problem is that an actual BItMex trailing stop isn't based on a close of a higher candle but on the live price reaching that value. Suppose a 1hr candle gives a low of 6200 but closed at 6300, a trailing stop at 6250 would be stopped out. But an indicator based on 4hr candle close wouldn't register that as stopped out, therefore not reflecting an actual BitMex trailing stop.
@rthomson, Okay. I see what you're saying, but need to process that in my head. I've modified it and playing around with it. I'm also thinking of using the modified version as manual entry or using Autoview to enter/exit, and I can also set the ts myself. I've changed tickerID to 60 and it does go further back in time. As a compromise, I may test setting it to say 5, 10 etc. As it happens it makes good calls in general for entry/exit when set to 60 and trailing set to 120ish for long and short I've noticed.


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Angelina Jolie spends S$31.9K a year on 'raindrop' facials
So ... this is how she looks so gorgeous?
A website has reported that actress Angelina Jolie apparently spends up to £15,000 (S$31,900) a year on facials.
Apparently she goes for a 'triad facial' laser treatment to maintain her bright, young, glowing complexion, according to TVNZ's One News, reporting from an article by BANG Showbiz.
Her dermatologist, Dr David Colbert, said: "People call it a facial but it is actually a non-invasive laser treatment."
"First we prep skin with microdermabrasion so the laser penetrates better. Then we use a laser, which feels like warm raindrops on the skin. After that, we do a lavender acid exfoliation, then apply gentle wave lights.
"The treatment takes about 35 minutes for the face or an hour for the whole body - we usually treat the arms and legs, the bits that will be on show.
"Most of our stars will have it before a big event - the Emmys or Oscars. People who are regularly in the media will come in monthly or every other month."
Actress Angelina Jolie goes for monthly 'triad facial' laser treatment to maintain her dewy look. Photo: AFP
Dr Colbert, who also works on Naomi Watts and Jennifer Lawrence, first treated the 39-year-old actress during her 2009 movie Salt.
He told Britain's Grazia magazine: "I've worked with her on several movies as a consultant where there has been prosthetic make-up.
For Salt, he created a special shea nut butter skin cream that was really gentle.
"It's called Heal and Soothe, 120 pounds (S$255), and helps keep skin looking calm and dewy."
Source: TVNZ One News
Get The New Paper on your phone with the free TNP app. Download from the Apple App Store or Google Play Store now


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Think back to middle school. Can you remember a classmate who often sat daydreaming in the back of the room, seemingly unengaged with the rest of the class's activities? Consider the frustration that student might have felt when faced with the fast-paced interactions of teachers and peers, and then again at home with exasperated family members.
If someone told you that this classmate had "slow processing speed," what would that mean to you?
Although it may sound like an obscure, mechanical term, slow processing speed is an identifiable issue that affects many children, both in their personal and academic lives. Bright Kids Who Can't Keep Up, by Ellen Braaten and Brian Willoughby, provides help for those who seek to assist such children in successfully navigating the rapid pace around them.
This is an easy-to-read, informative book. The authors guide parents through the process of identifying and evaluating children with slow processing speed, and they describe in detail what steps parents and school personnel can take to help children with this disability succeed.
Braaten and Willoughby also help parents who are concerned about their child's emotional and social well-being (or what many of us simply call "happiness"). They include specific strategies for working with teachers, coaches, and family members to help these children feel successful.
The book is written primarily for parents — and includes many specific tips. For instance, children with slow processing speed benefit from guidance with time, as they experience time differently than those with average processing speed. The authors encourage parents to use clocks with hands, instead of digital clocks, so that children can see the actual movement of time.
Children who experience slow processing speed also do better when given a routine that can be practiced repeatedly, they write. This includes following a specific route from class to class at school, since having a practiced routine can cut down on the time it takes. It eliminates the need to process and make decisions during those short periods of time.
Throughout the book Braaten and Willoughby stress their concept of the three A's: accept, accommodate, and advocate. Whether in the initial identification process, the classroom setting, or social and emotional situations, parents are to accept their children's characteristics, accommodate their needs, and advocate for them.
The tone of the book is collaborative. It encourages parents to advocate for their children along with other family members and adults — to form a supportive team for the child, rather than to take an adversarial approach.
As someone who has spent many years as a classroom teacher, I appreciate this team-oriented mentality.
In fact, I wish someone had handed me a copy of this book during my first year of teaching. I remember sitting in meetings with special education teachers and hearing the term processing disorder without having a clear understanding of how slow processing speed manifests itself in students' lives. This would be a great resource for any teacher, either to better understand these children or to share knowledge with parents.
In addition, the book has several user-friendly features, including checklists, sample case studies, clear and simple explanations about working with these kids, and a list of additional resources in the back. Psychologists who evaluate and work with children with learning disabilities might also use the book when interacting with parents.
Overall, Braaten and Willoughby take away the scientific, scary-sounding name of this learning disability and replace it with real examples of how these kids experience the world. They help readers appreciate that these kids are indeed bright — and that with some adjustments to their daily routine, they can achieve daily success, too.
Bright Kids Who Can't Keep Up: Help Your Child Overcome Slow Processing Speed and Succeed in a Fast-Paced World
The Guilford Press, July 2014
Paperback, 207 pages


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Agriculture experts have advised farmers to remove cotton sticks from fields before Jan 31 and apply Chisel plough so that pink bollworms undergoing diapause and their Pupae get killed.
Pink bollworm Pupae undergo diapause in winter season and convert into adult only when temperature touches or crosses 25 Celsius mark. Joint teams of agriculture extension and pest warning were moving from village to village to inform farmers about the hazards related to pink bollworm.
Pink bollworm is a dangerous pest, which after completion of cotton picking, survives on cotton crop remains to complete life cycle۔ Pest warning wing of the agriculture department was also installing pheromone traps at heaps of cotton sticks, at ginning factories and oil mills to monitor pink bollworm. Sticks carry pink bollworm undergoing diapause and thus be destroyed before Jan 31.


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Sure shot Option Strategy - YouTube
2/3/2007 · Call and put options are derivative investments (their price movements are based on the price movements of another financial product, called the underlying). A call option is bought if the trader expects the price of the underlying to rise within a certain time frame. A put option is bought if the trader expects the price of the underlying to fall within a certain time frame.
The Top 7 Stock Option Trading Strategies (of 2019)
8.1 – Choosing Calls over Puts Similar to the Bear Put Spread, the Bear Call Spread is a two leg option strategy invoked when the view on the market is 'moderately bearish'. The Bear Call Spread ..
Long Call Option Strategy - The Options Playbook
Mastering Options Strategies Written by the Staff of The Options Institute of the Chicago Board Options Exchange A step-by-step guide to understanding profit & loss diagrams
Like a covered call, a married put is one of the simplest and best options trading strategies. But the two strategies have very different purposes. The covered call limits your upside potential and enables you to produce an income income while the married put limits your downside risk and requires you to pay for portfolio protection.
Options Trading Strategies | Top 6 Options Strategies you
Using LEAPS Instead of Stock to Generate Huge Returns . Menu Search Go. Go. Investing. Basics Stocks Real Estate and see that you can purchase a call option expiring the third weekend in January of 2011, nearly 20 months and 3 weeks away, with a strike price of $17.50. with a strike price of $17.50. Put simply, that means that you have
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Oscreener allows users to screen through Bull Put Spreads and Bear Call Spreads, Bull Call Spreads, Bear Put Spreads, long calls, long puts, short puts, backtest selected options spreads. Evaluate option strategies based on risk sensitivities and related stock technical analysis Screener. Options Backtester.
Best Options Trading Strategies: The Married Put
What is your most successful option-trading strategy? My strategies I've set are: Contra Call - Given me a guaranteed 95% success rate till date from 2013. Scalp Trading - Gave me a success rate of 83% till date from 2013. It will have both Call option and put option.
Binary Options Trading Strategies •
Buying a Call Option is the most basic of all the Option strategies and is the most efficient strategy to optimize a bullish outlook on a stock. In this course, we take the example of Chipotle Mexican Grill (CMG) and show how the trade played out.
Call and Put Options With Definitions and Examples
The 2 Best Options Strategies, According To Academia. concluding that while many option strategies lose money, put selling is one of the few option strategies that outperforms a buy-and-hold
Learn Best Option Trading Basic Strategies | ideas
What is the best options trading strategy? Update Cancel. a d b y P a r a b o l a. i o. What is the best data validation tool for spreadsheet data, like DataCleaner, Talend, Google Refine? It will have both Call option and put option. Which brokerage is best for option strategies? Related Questions.
The 15 Most Active Call & Put Options of the S&P 500
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WINNING STOCK & OPTION STRATEGIES DISCLAIMER Although the author of this book is a professional trader, he is not a registered financial adviser or financial planner.


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CAVE CREEK — Foothills Food Bank & Resource Center seeks donors to brighten the holiday season for children, families and seniors in the northern Arizona foothills community as part of the food bank's 17th annual Adopt-a-Family program. Foothills Food Bank is working with hundreds of individuals donors as well as more than a dozen local organizations and churches to provide gifts, holiday meals and hope for those in crisis in the community.
According to Pam DiPietro, executive director for Foothills Food Bank, all families must be signed up by Dec. 6. Individual donors as well as donor groups such as businesses, HOAs, churches and schools are encouraged to participate in this year's Adopt-a-Family program. Interested donors determine the size of the family they are willing to adopt then a family wish list is provided as a shopping guide. Monetary donations also are accepted to support the program. All gifts must be wrapped and delivered to Holland Community Center by Dec. 12. Checks are payable to Foothills Food Bank. All gifts and donations are tax deductible according to tax laws. In 2018, the program served 393 families for a total of 1,226 individuals, with an additional 300 people added annually.
For information about the 2019 Adopt-a-Family program or to become a donor, visit foothillsfoodbank.com. Foothills Food Bank & Resource Center is located at 6038 East Hidden Valley Drive in Cave Creek.


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When: Wed., Feb. 8, 7 p.m. 2012
While I associate "virtual reality" with bad '80s sci-fi, Jaron Lanier (Silicon-valley prodigy, scientist, artist and musician) reportedly coined the term and continues to consider "media technology as a grand exploration of unimagined human potential." One of Time's 100 most influential people of 2010, Lanier will be speaking on how technologies like the Xbox Kinect have reinvented virtual reality, and what can be anticipated in the tech future. The hour-long free lecture will begin at 7 at CC's Cornerstone Arts Center (825 N. Cascade Ave., coloradocollege.edu). — Sara Michael
Price: Free


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From literature I know that a few TCGA samples have also information about treatment. It isn't clear to me how to obtain that information. After downloading the clinical data sets with TCGAbiolinks package I see one column "treatment_id". Each TCGA sample has a code in this column, looking like this: dbf26982-97b4-59f7-b165-d3889623bc21.
I can't figure out what that means, or how I can translate the code into drug name. Any ideas? Or is there an other way, how to obtain the treatment information outside the "clinical data information"?


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Dj TY1
Dj Ty1, sicuramente uno dei più talentuosi Dj Italiani da sempre alla ricerca di codici espressivi originali e contemporanei.
Inizia la sua carriera negli anni 90, scratch e hip hop sono state le sue prime attrazioni. Primo all'ITF nel 97 si affilia ad Alien Army pionieri di Turntablism in Italia.
Nel 2007 esce il suo primo album Photographie, nel 2010 vince il premio Insound come miglior diskjockey.
Nel 2011 partecipa al progetto Gli Originali, un riuscitissimo esperimento tra Franco Micalizzi e la sua band da un altro ed Mc Italiani e Dj dall'altra.
Ad oggi dj di due massimi esponenti della scena musicale Italiana, i due rapper Marrakesh e Clementino.
"Hardship"è il suo ultimo lavoro uscito nel 2016
TY1 aka Tayone, born Gianluca Cranco – class 1979 – is the most famous and talented DJ in the Italian Hip-Hop scene. He started his career in 1992 approaching dance and hip hop music, with a special focus on the scratch art.
In 1997 TY1 became Italian ITF champion and joined the historical Italian turntablist crew Alien Army. Since 1998 TY1 attended several contests and tours and worked together with many great musicians.
In 2010 TY1 won the Insound Best DJ award.
Right after he became tutor for Rane America and endorser for Serato Scratch Live, thanks to his unique way in mixing and scratching.
On 31st of October 2013 TY1 released his new hit single "Gunboy (Trinity Remix)" feat. Pat Cosmo out on Digital Bros Music.
DJ and producer behind the main Italian Hip Hop artists, TY1 has now kicked off a new artistic cycle moving towards electronic and pop sonority: his last productions sound incredibly engaging and mature – an eclectic pop with an electronic streak.
On June 2015 TY1 released in free download "What is a DJ" anticipating the upcoming "Hardship" album, to be released on January 2016. The album will mark the evolution of TY1 from the stereotyped DJ/Producer role to a new artistic phase as a whole-grown artist.
Hardship is a hard-sounding electro-pop body of work that boasts the collaboration of various famous international guest-artists.


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This isn't a plantation museum like any other one already existing or in the process of being resurrected as a tourist destination.
Mr. JC is creating a memorial to all the slaves who worked and died in Louisiana, and to the slaves on the Whitney in particular. It's not difficult for perceive the entire entity as an enormous altar, composed of many interlocking moving parts. An historical slave labor plantation was a factory-prison of many interlocking moving parts, the most important of the parts, the laborers.
The plantation chapel is filled with sculpture replicas of the Whitney's children – whom John knows all by name. The sculptures are filled with life and presence. The children see you. They are judging, though neither cruel nor kind, just present. The sculptor who has called them back from the past is Rod Moorhead. Behind the chapel is the Field of Angels, dedicated slave children. Presiding over this Memorial is a beautiful black angel, wings sweeping out, protectively receiving a tiny infant in her arms. One of the Field of Angels memorial plaques reads:
The Field of Angels is in honor of the 2200 slave infants born in St. John the Baptist parish who perished prior to the second birthday. They were deposited in earthen holes on the plantations and occasionally at the catholic church cemetery.Behind this memorial surrounded by willows weeping veils of spring green gauze are other commemorative art, which, so far is represented by a classic columned octogonal gazebo. Like the chapel this extensive area too is a deeply spiritual space. Because the children are called by name these are places of power, that contain both peace and sorrow. Sorrow for this terrible world human beings dreamed into existence for the sake of selfish, greedy convenience. Peace because John is a magician who has created a world to come, a world of healing for the world of evil passed away far too late.
After the tour we were guided back to the present by a cajun lunch at the B & C Seafood Restaurant on Highway 18.
Our second guide into Whitney's past is Ibrahima Seck. He drove us to the plantation and back again (el V and Ibahima had met more than once previously, but this was my first opportunity to spend time with this brilliant historian and scholar). What he has to say when talking about American blues is informative and exciting, as is everything else he thinks about. (Blues ultimately has its roots in the music Ibrahima grew up on, among other things that makes him so well educated in the elements of the form.)
On the way back, filled with gratitude for the riches of this day, I was able to be peacefully silent, able to witness the beakneck speed the swamp world's spring time renewal. We drove out from New Orleans between 10 and 11 AM and back from the Whitney between 4 and 5 PM. In that time the trees all along the highway had burst into bloom. The female of the current twenty-some generation of a bald eagle family that has held that huge nest visible from the highway, had gone into brood mode -- or maybe egg laying? She wasn't in the nest in the morning, but flapping and perching alternately as we drove along the highway. While we went and returned she decided to get to her business.
Spring is here, if not there ....
And, our faces are fairly finely sunburned.


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Please! No more change…
Barack Obama is the worst jobs president since the Great Depression. The Obama-Pelosi economic plan resulted in a cumulative 7.5 million jobs deficit. By every objective measure the democrat's Trillion dollar stimulus bomb was a complete disaster.
Barack Obama and Nancy Pelosi tripled the national deficit last year by nearly a trillion dollars – something unheard of in our nation's history.
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After an unheard of record deficit last year of $1.4 Trillion the democrats managed to compile a $1.3 Trillion deficit this year.
Instead of focusing on the economy the past two years the radicals in Washington beat up on business and rammed through an unpopular nationalized health care entitlement program. Today 61% of voters want the democratic law repealed.
TRENDING: BREAKING: Black Lives Matter Rioters in Hollywood Chase Down and Attack Driver.. UPDATE... DRIVER DETAINED BY POLICE (SHOCKING VIDEO)
Today, at a rally for far left Democrat Russ Feingold, the First Lady begged voters for more time to forge change.
The Sydney Morning Herald reported:
US First Lady Michelle Obama yesterday poignantly said she felt the economic anxiety of hurting Americans, but pleaded with them to give her husband more time to forge the change he promised.
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"I think that many of us came into this expecting to see all the change we talked about happen at once, right away, the minute Barack walked through the Oval Office door," she said…
"I know that a lot of folks are still hurting, I know that for a lot of folks, change hasn't come fast enough."
The First Lady was making her debut on the 2010 campaign trail, three weeks ahead of congressional elections in which voters are expected to inflict heavy losses on Democrats which could stall her husbands reform agenda.
"We all understood that change takes struggle, and sacrifice and compromise," Obama said, campaigning for endangered Democratic Senator Russ Feingold in midwestern Wisconsin.
With pollsters pointing to an "enthusiasm gap" between Barack Obama's supporters and conservatives outraged by his presidency, the White House is trying to drive the president's diverse, youthful coalition to the polls.
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"In the end, our campaign was never just about just pulling one man and putting him into the White House," she said, urging supporters to remember how the election night in 2008 and Obama's inauguration in January 2009.
"We were excited, we were energised, we were hopeful … and the truth is, we have that same chance – and we have that same responsibility – today."
Obama said she came to the campaign "as a Mom" and realised what was at stake.
"I see it in the child whose dad has just been deployed and is trying to hard to be brave for his younger brothers and sisters."
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"I see it in the child stuck in a crumbling school, who looks around and wonders 'what on earth is this going to mean for my future?
She sounds a bit ridiculous talking about the suffering of the average American. After all, she just returned from a royal vacation in southern Spain.


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The MTConnect Institute, the developer and administrator of MTConnect, announces the release of the MTConnect standard version 1.3.0. The MTConnect standard is an open-source communication standard for interoperability of manufacturing equipment and devices. This version provides significant features, which include inter-device connectivity to enable machine-to-machine communication, additional data items for equipment and devices, as well as improvement to readability of the standard documents. With this release, the MTConnect Institute also launches the MTConnect User Portal, a community site for implementation best practices and shared experiences about implementation of the standard.
"The addition of version 1.3.0 of the MTConnect standard is a huge step forward for manufacturing and MTConnect. With 1.3.0, we can expect a new level of innovation and capabilities from manufacturing software vendors because of the ease of access to shop floor data MTConnect affords the industry," said Courtney Hill, President and Chairman of the MTConnect Institute Board.
MTConnect® Institute is an organization that develops and provides an open standard intended to foster greater interoperability between manufacturing controls, devices and software applications by publishing data over networks. The standard offers a solution to the exchange of data from shop floor devices to higher level systems.
MTConnect is an open, royalty-free, secure standard that provides a common transport and format for all manufacturing data from all devices. It enables interoperability, as well as reduces the complexity and increases the value that can be delivered by software applications.
MTConnect Institute is a not-for-profit 501(c)(6) organization established to further the development and adoption of the MTConnect standard. The organization is a subsidiary of AMT—The Association For Manufacturing Technology and includes Board of Trustees, Technical Steering Committee, and Technical Advisory Group (TAG), which is comprised of various working groups to further the standard in specific technology areas. Any company or organization can become a member of the Institute and membership is free.
For more information, visit: www.MTCup.org
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Information: Citation Report - Web of Science [v.5.34]
Dear Authors,
We hope we found you well.
Thank you for your intresest in IJMP and for your valuable papers. Due to your prestigious work IJMP is now indexd in Web Of Science.
We hope in a continuos evolution of our journal, in order to be able to answer to your requests and increase the visibility of your articles.
You might help us in this regards by reading articles on your interests from IJM&P and citing its in other publications, especialy Web of Science and Scopus publications.
Thus IJM&P will have a higher impact factor and a greater visibility from year to year.
You may find other articles using "search tool" of out platform.
|Posted: 2020-04-02
Information: indexed by the Polish Ministry of Science and Higher Education (MSHE)
|I would like to take this opportunity to inform you that your journal has been indexed by the Polish Ministry of Science and Higher Education (MSHE) on the list of scientific journals recommended for authors to publish their articles.
|Posted: 2020-03-12
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Is this a photo of the new Chrome OS netbook keyboard? It has a SEARCH key.
The folks over at Engadget has posted an interesting photo that they believe is the keyboard on board Google's rumored Chrome OS netbook that likely will be unveiled at an event next Tuesday in San Francisco.
At first glance, it appears to be an ordinary keyboard. Look again though. There is a key on the left hand side there, above Shift and below Tab that says Search. That's of course in the place where the Caps Lock key usually resides.
Let the speculating begin.
And in less exciting news, there are also forward and back keys placed right up above the row of numbers.
The tipster that sent the photo in claims that Google's netbook is going to be headed to shelves on December 14th, 7 days after Google's Chrome OS event so it looks like Tuesday might just be an announcement and not a full-fledged launch.
Whatever the case may be, we'll find out in just a few short days and we'll be there to cover the action for you from the event itself.
Read next: Osfoora for Mac Sneak Peak-Desktop Twitter Clients Still Hot


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SNOWSHOE, West Va. — Gadsden's Randy Kerr on July 19 brought home his fourth straight cycling national title, as he won the 2018 USA Cycling Mountain Bike National Championship in the cross country event in the Master ages 60-64 field.
Kerr previously won two titles in the Master ages 55-59 field, then won last year in the 60-64 group.
The race was Kerr's first of the year.
Early in the race, Kerr suffered a fall and fell behind four other riders, to the point that they were out of Kerr's sight. However, he kept battling and caught up to them on a long sustained climb with a steep kicker at the top. From there, Kerr battled the foursome until the final lap, when he created a gap of over two minutes on them that allowed him to cruise to the win.
His final time of 1:23:41 was five minutes faster than he ran in last year's race.
"Heck, I hate to say it, but I was in pain from the very beginning... I was ready for it to be over," Kerr said. "I wanted the pain to stop.
"To refocus the pain, I kept repeating this verse in my head: 'God, after you have suffered a little while, will himself restore you and make you strong, firm and steadfast.' After reflecting back on the race, I would have to say this was one of the hardest things I've ever done."
George Smith of Menlo Park, Calif., finished second at 1:25:47, five seconds ahead of third-place finisher Dennis Barber of North Vernon, Ind.


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Anticancer properties of the novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide in vitro and in vivo
Authors:Maksimović-Ivanić, Danijela
Mijatović, Sanja
Harhaji Trajković, Ljubica
Miljković, Đorđe
Dabideen, Darrin
Cheng, Kai Fan
Mangano, Katia
Malaponte, Graziella
Ai-Abed, Yousef
Libra, Massimo
Garotta, Gianni
Nicoletti, Ferdinando
Stošić-Grujičić, Stanislava
Document Type:
Article (Published version)
© 2008 American Association for Cancer Research
MetadataShow full item record
Preclinical studies have shown that nitric oxide (NO)donating nonsteroidal anti-inflammatory drugs possess anticancer activities. Here, we report in vitro and in vivo studies showing the antitumor effect of the NO-donating isoxazole derivative (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid (GIT-27NO). GIT-27NO, but not the NO-deprived parental compound VGX-1027, significantly affected viability of both rodent (L929, B16, and C6) and human (U1251, BT20, HeLa, and LS174) tumor cell lines. GIT-27NO triggered either apoptotic cell death (e.g., L929 cells) or autophagic cell death (C6 and B16 cells). Moreover, GIT-27NO hampered the viability of cisplatin-resistant B16 cells. NO scavenger hemoglobin completely prevented GIT-27NO-induced death, indicating that NO release mediated the tumoricidal effect of the compound. Increase in intracellular NO upon on the treatment was associated with intensified production of reactive oxygen species, whereas their neutralization by antioxidant N-acetylcysteine resulted in partial recovery of cell viability. The antitumor activity of the drug was mediated by the selective activation of mitogen-activated protein kinases in a cell-specific manner and was neutralized by their specific inhibitors. In vivo treatment with GIT-27NO significantly reduced the B16 melanoma growth in syngeneic C57BL/6 mice. The therapeutic effect occurred at dose (0.5 mg/mouse) up to 160 times lower than those needed to induce acute lethality (80 mg/mouse). In addition, a dose of GIT-27NO five times higher than that found effective in the melanoma model was well tolerated by the mice when administered for 4 consecutive weeks. These data warrant additional studies to evaluate the possible translation of these findings to the clinical setting.
Source:Molecular Cancer Therapeutics, 2008, 7, 3, 510-520
PubMed: 18347138


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http://www.toxicteeth.org/ learn about the toxicty of dental filings
wellnessresources.com Nutrition and health and medical politics
Garynull.com Lots of goodies. Can't learn from CNN.
Center for Medical Consumers do not accept financial aid from th drug industry.
http://www.chinesemedicinenews.com publishes some Chinese medicine news irregularly.
http://www.cancure.org - a good source for alternative cancer treatments.
http://www.feingold.org/ -- The Feingold® Association of the
United States is dedicated to helping children and adults apply proven dietary techniques for better behavior, learning and health, and to generating public awareness of the potential role of foods and synthetic additives in behavior, learning and health problems.
http://www.aicr.org - American Institute of Cancer Research is an organization that is interested in investigating how diet and lifestyle affect cancer risk.
http://www.vitaminb17.org - This site publishes information on vitamin B 17, which is claimed to have anti-cancer activity.
http://www.fluoridealert.org - this is a great site that reveals all types of adverse effects fluoride may cause in human beings. If you think your municipal water system does any good by fluoridating your tapwater, you need to think again.
DrDay.com -- A distinguished physician who once suffered serious breast cancer has recovered from the disease without using conventional medicine and been well for nearly a decade. She told her story on her website that may be interesting to those who believe in alternative treatments of cancer.
Marlerblog -- http://www.marlerblog.com/ Bill Marler is a very active food poisoning lawyer. His firm also maintains a not-for-profit website, which is a great source of information on foodborne pathogens and food recalls.
Food Law Prof Blog -- http://lawprofessors.typepad.com/foodlaw/ This is a shameless plug. I edit this "blog." It's more of a food law-related headlines service than a blog. I don't write much commentary. Topics of interest are anything to do with food law or policy from agricultural to processing to labeling to health issues.
Food Policy Blog -- http://usfoodpolicy.blogspot.com/ . Edited by food economist Professor Parke Wilde. This is one of my favorite food policy websites. I respect the writing and trust the source.
www.bioinitiative.org A Rationale for a Biologically-based Public Exposure Standard for Electromagnetic Fields (ELF and RF)
http://www.cancerproject.org This is a good site that promotes use of proper diet to fight against a variety of cancers.
http://www.essiacinfo.org/ At her clinic in
Canada, many cancer sufferers claimed they had years added to their lives...
www.centerforfoodsafety.org Challenging harmful food production technologies and promoting sustainable alternatives.
http://rachel.org/home_eng.htm Providing understandable scientific information about human health and the environment.
Got a baby to deliver? Consider hiring a midwife for a gentle and loving hand. A midwife can help you without using dangerous drugs and tools that ob/gyn use often.
www.organicconsumers.com Read the site for updated what's going on in the organic industry. What the consumers can do to protect their organic foods.
www.cancertutor.com This may be one of the comprehensive site that collects all the information on alternative cancer therapies.
www.EWG.org A not-for-profit organization promoting environmental health. It publishes many topics that you can't read elsewhere.
www.foodnews.org You think all foods are the same in terms of safety. Think again. The site tells you what you need to avoid to minimize your exposure to pesticides.
www.commonground.ca A magazine dedicated to health, wellness, ecology and personal growth.
www.rense.com Read all the interesting subjects including food and health, updated often.
www.rachel.org A site monitoring environmental health and policies.
www.citizen.org Public citizen - the veteran advocate for consumers' interest and rights.
www.preventcancer.com A professor tells something that you can use to prevent cancer.
www.radical.org Read articles by John Gofman, a distinguished professor of UCLA and get to know what risk x-ray imposes on patients. According to his lengthy report, 75 percent cancer cases are exposed to x-ray.
www.newstarget.com A site publishing all types of news on alternative health.
www.vitamincfoundation.org Tons of information on use of vitamin C as a therapeutical to treat many diseases including cancer.
www.TheChinaStudy A book by
University nutritionist T. Colin Campbell who tells you in the book why in the West, so many chronic diseases strike so many people and how to easily prevent diseases by adopting a healthy diet.
www.truthinlabeling.org A site publishing secrets about the toxicity of MSG.
www.centerforfoodsafety.org A non-profit public interest and environmental advocacy membership organization established in 1997 by its sister organization,
Center for Technology Assessment, for the purpose of challenging harmful food production technologies and promoting sustainable alternatives.
www.consumerworld.org Tons of information for consumers.
www.iicph.org/index.shtml International Institute of Concern for Public Health
www.notmilk.com Milk does the body good, right? But this site tells a different story about milk. Be prepared to get shocked.
www.pcrm.org Not all physicians are conventional. Some physicians involved in the organization are open to alternative treatments.
www.yourhealthbase.com Lots of informative health information on controversial issues, updated 10 times a year.
www.Curezone.com One of most active sites of alternative medicine, lots of testimonials.
www.drrathresearch.org Many cancers may not be as scary as thought as long as you get the right treatment. This research organization pursues alternative treatments for cancer and other diseases, which have helped many patients as claimed.
Institute of Responsible Technology It is interesting to those who want to learn about genetically modified organisms (GMOs)
Preventive Medicine Research Institute According to Dr. Dean Ornish, heart disease can be prevented or even cured without medicine. How? Follow a healthy lifestyle and eat a healthy diet.
http://www.whale.to / This site may help consumers to understand how the medical business is being run. Those who count on doctors and hospitals for their health needs may find them shocked by reading the articles on the site.
www.knowledgeofhealth.com The site run by
health journalist Bill Sardi offers tons of health information that the mainstream news media could not offer. Those who are not happy with the reporting of the major news outlets should take a look.
www.prostate90.com/book/bio.html Diagnosed with prostate cancer? Considering chemotherapy and or radiotherapy while you have no insurance as to how effective they are? Dr. Larry Clapp says you don't need any conventional invasive treatments. 90 days of alternative treatments get you back to normal.
www.scorecard.org Every family moves on average once every eight years. But do you know how environemntally safe the city you are moving to is? Check out scorecard.org, which gives you detailed information on the environment safety of your city.
www.bestplaces.net You get paid $80k a year in
Wisconsin. Now you want to move to
Texas for a job which offers $95. The question you have is, is the salary better off or worse off? Bestplaces.net gives you that type of answer.
http://lpi.oregonstate.edu/ Lots of current information on nutrients and diseases. You got to read it to appreciate it.
"Foresight and Precaution, in the News and in the World"
http://www.hir.nu/Publications.htm This is an excellent source of EMF and cancer managed by real authorities in the area.
To recommend a site, please contact us at [email protected]
Disclaimers: Listing of the sites does not mean endorsement from foodconsumer.org. Readers need to be careful rea ding any sites on any subjects.
© 2004-2008 by foodconsumer.org unless otherwise specified
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